ncRNA Symbol ncRNA Category Species Disease Name Sample Dysfunction Pattern Validated Method Description Clinical Application Causality Causal Description PubMed ID ARHGAP5-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Epigenetics( m6 A-modified) qRT-PCR Among these lncRNAs, we found that ARHGAP5-AS1 is the lncRNA with the highest levels of m6 A modification and significantly increased expression in HCC specimens. METTL14 acts as the m6 A writer of ARHGAP5-AS1 and IGF2BP2 stabilises the lncRNA as its m6 A reader.We identified oncoprotein CSDE1 working as the interacting protein of the lncRNA and TRIM28 as the E3 ligase of CSDE1 in HCC. Interestingly, ARHGAP5-AS1 could attenuate interactions between CSDE1 and TRIM28, which prevents the degradation of CSDE1 via the ubiquitin-proteasome pathway. Elevated levels of CSDE1 coordinate oncogenic RNA regulons, promote translation of VIM and RAC1 and activate the ERK pathway, which contributes to HCC prognosis. Yes ARHGAP5-AS1 remarkably promotes malignant behaviours of HCC cells ex vivo and in vivo. 36354136 HOTTIP LncRNA Homo sapiens Osteosarcoma OS tissues Interaction(PTBP1/KHSRP ) qRT-PCR//RIP Our data demonstrated HOTTIP was upregulated in OS tissues. In mechanism, PTBP1 and KHSRP highly expressed in OS and HOTTIP was identified to interact with PTBP1 to promote KHSRP expression. Meanwhile, we found that overexpression of KHSRP or PTBP1, individually, can partially remove the repression of HOTTIP suppression for OS cell progression. Yes HOTTIP knockdown resulted in a suppression of OS cell proliferation, invasion and migration, as well as a promotion of OS cell apoptosis, while HOTTIP overexpression exhibited opposite effects. 33475442 HOTTIP LncRNA Homo sapiens Glioma SF268 cells Interaction(miRNA-10b/Zeb1/Zeb2) Transfection//Migration Assay//qRT-PCR//MTT//ELISA lncRNA HOTTIP was found to be particularly elevated in SF268 cells and over-expression of HOTTIP in both A172 and LN229 remarkably increased their TMZ IC-50s, along with increased cell proliferation, migration, clonogenicity and markers of angiogenesis and metastasis. As a mechanism we observed increased expression of miRNA-10b and mesenchymal markers Zeb1/Zeb2 and reduced expression of E-cadherin in SF268 cells indicating a role of EMT in TMZ resistance. A172 and LN229 cells with overexpressed HOTTIP also had similarly induced EMT and the elevated miR-10b levels. Further, silencing of miR-10b in HOTTIP overexpressing cells as well as the SF268 cells reversed EMT with associated sensitization of all the tested cells to TMZ. Yes lncRNA HOTTIP was found to be particularly elevated in SF268 cells and over-expression of HOTTIP in both A172 and LN229 remarkably increased their TMZ IC-50s, along with increased cell proliferation, migration, clonogenicity and markers of angiogenesis and metastasis. 35402278 HOTTIP LncRNA Homo sapiens Retinoblastoma RB tissues and cells Interaction(miR-101-3p/STC1 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//IHC HOTTIP expression was promoted in RB tissues and cells. There were target relationships between HOTTIP and miR-101-3p, and miR-101-3p and STC1. Inhibition of miR-101-3p or overexpression of STC1 reversed the effect of si-HOTTIP on the proliferation and apoptosis of RB cells. Yes Downregulation of HOTTIP inhibited proliferation and promoted apoptosis of Y79 cells, while upregulation of HOTTIP promoted proliferation and inhibited apoptosis of HXO-RB-44 cells. 33784880 HOTTIP LncRNA Homo sapiens stomach carcinoma cell lines MGC-803, HGC-27, SNU-1, and SGC-7901 regulation[adsorbing miR-615-3p] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay " LncRNA HOTTIP was highly expressed in gastric carcinoma cell lines MGC-803, HGC-27, SNU-1, and SGC-7901 than in normal gastric mucosa cell line RGM-1.It affects cell proliferation and apoptosis in gastric carcinoma by adsorbing miR-615-3p via a sponge effect. " Yes After knockdown of lncRNA HOTTIP, the proliferation function of gastric carcinoma cells was markedly weakened, and the proportion of apoptotic cells increased. 32633359 HOTTIP LncRNA Homo sapiens Nasopharyngeal Neoplasms NPC tissues Interaction[Inhibiting miR-4301 ] CCK8//qRT-PCR//Transwell Assay HOTTIP expression was increased in NPC tissues.HOTTIP silencing suppressed the proliferation, cell cycle, migration, and invasion of NPC cells. Higher levels of HOTTIP are correlated with lower survival in NPC patients. Yes HOTTIP silencing suppressed the proliferation, cell cycle, migration, and invasion of NPC cells. 30685769 HOTTIP LncRNA Homo sapiens Arthritis, Rheumatoid rheumatoid arthritis synovial fibroblasts Interaction(miR-1908-5p/STAT3 axis) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA We found that HOTTIP was upregulated in rheumatoid arthritis synovial fibroblasts (RASFs).HOTTIP directly bound to miR-1908-5p and negatively modulated miR-1908-5p expression while positively regulating STAT3. Yes In addition, in vivo experiments demonstrated that overexpression of HOTTIP aggravated inflammation in RA mice, which was demonstrated by hematoxylin and eosin (HE) staining and the increased expression levels of CD4+ interleukin (IL)-17+, forkhead Box P3 (FOXP3) and retinoid-related orphan receptor gamma-t (RORγt) 34808131 HOTTIP LncRNA Homo sapiens Mouth Neoplasms oral cancer tissues Interaction(miR-206) qRT-PCR//Transfection//Wound Healing Assay//Transwell Assay HOTTIP was abnormally increased in oral cancer. Besides, when HOTTIP was knocked down in oral cancer cell lines, miR-206-206 was remarkably up-regulated. Dual-luciferase reporter gene experiment confirmed the binding relationship between miR-206 and HOTTIP. At the same time, the survival analysis showed that the higher expression of HOTTIP was significantly correlated with a shorter overall survival. Yes The results of cell functional experiments found that HOTTIP played a role in promoting tumor proliferation and migration in oral cancer cells. B 34268933 HOTTIP LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OTSCC tissues and cells regulation[HMGA2-Mediated Wnt/β-Catenin Pathway] qRT-PCR//MTT//Western Blot//Transwell Assay HOTTIP was upregulated in OTSCC tissues and cells, and was highly expressed in positive lymph node metastasis and late-stage OTSCC patients. HOTTIP knockdown restrained proliferation, migration, and invasion of OTSCC cells by miR-124-3p/HMGA2 axis through Wnt/β-catenin pathway. HOTTIP was upregulated in OTSCC tissues and cells, and was highly expressed in positive lymph node metastasis and late-stage OTSCC patients. Yes Silencing HOTTIP impeded proliferation, migration, and invasion of OTSCC cells. Moreover, HOTTIP knockdown inhibited proliferation, migration, and invasion of OTSCC cells by targeting miR-124-3p. 31910357 HOTTIP LncRNA Homo sapiens Lung Diseases A549 cells and Lung tissues of mouse model Interaction(miR‑744‑5p/PTBP1 signaling axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//EdU Staining//IF The results of the present study revealed that the proliferation and migration of A549 cells were both suppressed following the knockdown of HOTTIP. The lncRNA HOTTIP was found to target and downregulate the expression levels of miR‑744‑5p. Furthermore, miR‑744‑5p targeted and downregulated the expression levels of PTBP1. Yes The knockdown of lncRNA HOTTIP expression also relieved the fibrosis of the lung tissues of mice. 34212978 HOTAIRM1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Regulation[miR-17-5p/ PTEN axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Microarray HOTAIRM1 and phosphatase and tensin homolog (PTEN) were both downregulated in GC, whereas miR-17-5p was upregulated.Moreover, the PI3K/AKT pathway was found activated in GC. HOTAIRM1 targeted miR-17-5p, whereas PTEN was the downstream target gene of miR-17-5p. Yes HOTAIRM1 suppressed proliferation and migration of GC cell line and induced their apoptosis, whereas miR-17-5p played the opposite role on GC cell line. HOTAIRM1 also postponed tumor growth in vivo and inhibited the PI3K/AKT pathway in GC. 30302796 HOTAIRM1 LncRNA Homo sapiens Breast Neoplasms breast cancer cells and patients Regulation(SYN2 ) qRT-PCR//Migration Assay//Cell Viability Assay//Western Blot Results from univariate and multivariate Cox regression showed that SYN2, HOTAIRM1, BCAS1, and ALDOC were significantly associated with patient prognosis. Results from in vitro experiments showed that knockdown HOTAIRM1 expression promoted breast cancer cells proliferation, clone formation, and invasion. Up-regulation of HOTAIRM1 inhibited breast cancer cells proliferation, clone formation, and invasion. Results from univariate and multivariate Cox regression showed that SYN2, HOTAIRM1, BCAS1, and ALDOC were significantly associated with patient prognosis. Immunohistochemistry and quantitative real-time polymerase chain reaction (qRT-PCR) results showed that the expression levels of SYN2 and HOTAIRM1 were negatively correlated with BRCA stage, whereas those of BCAS1 and ALDOC were positively correlated with BRCA stage. Yes Results from in vitro experiments showed that knockdown HOTAIRM1 expression promoted breast cancer cells proliferation, clone formation, and invasion. Up-regulation of HOTAIRM1 inhibited breast cancer cells proliferation, clone formation, and invasion. 35694102 HOTAIRM1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues cells or exosomes Interaction(miR-498/ABCE1 axis) In Vivo Experiment//Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Invasion Assay//Transwell Assay HOTAIRM1 expression was dramatically upregulated, whereas miR-498 expression was significantly downregulated in NSCLC tissues cells or exosomes as compared to control groups. Functionally, HOTAIRM1 functioned as a sponge of miR-498 and miR-498 targeted ABCE1. In addition, HOTAIRM1 silencing inhibited NSCLC growth in vivo by downregulating ABCE1 and upregulating miR-498 expression. Yes Mechanistically, HOTAIRM1 knockdown repressed cell viability, migration, invasion and glycolysis metabolism, whereas induced cell apoptosis in NSCLC; however, miR-498 inhibitor hindered these effects. 33537917 HOTAIRM1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[Wnt signaling pathway] CCK8//qRT-PCR//Flow Cytometry//Western Blot Lower lncRNA HOTAIRM1 expressions were observed in the HCC tissues than those of the paracancerous tissues.HOTAIRM1, which was downregulated in HCC, might inhibit the proliferative ability and promote the apoptosis of HCC cells by suppressing the Wnt pathway, thereby inhibiting the progression of hepatocellular carcinoma. ROC curve indicated a high sensitivity and specificity of lncRNA HOTAIRM1 for HCC. PFS in HCC patients was correlated with tumor size and lncRNA HOTAIRM1 expression, whereas not correlated with age, sex, GGT, AFP, Child-Pugh grade, HBsAg, cirrhosis, number of tumors, micro-vessel metastasis, tumor differentiation, and TNM stage of HCC. Yes Overexpression of HOTAIRM1 led to decreased proliferative ability and increased apoptosis of HepG2 and HHCC cells. 30070317 HOTAIRM1 LncRNA Homo sapiens Ovarian Neoplasms OC tumor tissues and cells interaction[ARHGAP24 ,miR-106a-5p] RNA Pull-Down//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay HOTAIRM1 expression was lowered in OC tumor tissues and cells.In conclusion, our study showed that HOTAIRM1 suppressed OC progression through derepression of ARHGAP24 by sponging miR-106a-5p. Decreased HOTAIRM1 expression was associated with advanced FIGO stages and lymphatic metastasis. Yes Up-regulation of HOTAIRM1 suppressed OC cell proliferation and invasion, and promoted apoptosis. 31935390 HOTAIRM1 LncRNA Homo sapiens Ovarian Neoplasms skov3 cell Expression [highly expressed] qRT-PCR//Western Blot HOTAIRM1 was overexpressed in SKOV3 cells. Yes Silencing of HOTAIRM1 alleviated cell proliferation, and increased cell apoptosis of SKOV3 cells. Moreover, siHOTAIRM1 significantly increased expression of pro-apoptotic agents, such as Bad and Bax, while it decreased expressions of Bid and Bcl-2 (anti-apoptotic agents). Also, silencing of HOTAIRM1 resulted in a suppressed expression of Wnt pathway-related proteins and also expression of its downstream target gene, matrix metalloproteinase 9(MMP9). 33939846 HOTAIRM1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Expression(highly expressed) qRT-PCR//Colony Formation Assay//Western Blot This study identified HOTAIRM1 as a novel significantly upregulated lncRNA in OSCC, which is strongly associated with unfavorable prognosis of OSCC. This study identified HOTAIRM1 as a novel significantly upregulated lncRNA in OSCC, which is strongly associated with unfavorable prognosis of OSCC.Systematic bioinformatics analyses demonstrated that HOTAIRM1 was closely related to tumor stage, overall survival, genome instability, the tumor cell stemness, the tumor microenvironment, and immunocyte infiltration. Yes HOTAIRM1 plays a pivotal role in OSCC cell proliferation, and is mainly involved in the regulation of the cell cycle. In vitro, cell loss-functional experiments confirmed that HOTAIRM1 knockdown significantly inhibited the proliferation of OSCC cells, and arrested the cell cycle in G1 phase. At the molecular level, PCNA and CyclinD1 were obviously reduced after HOTAIRM1 knockdown. The expression of p53 and p21 was upregulated while CDK4 and CDK6 expression was decreased by HOTAIRM1 knockdown. In vivo, knocking down HOTAIRM1 significantly inhibited tumor growth, including the tumor size, weight, volume, angiogenesis, and hardness, monitored by ultrasonic imaging and magnetic resonance imaging 35087800 HOTAIRM1 LncRNA Homo sapiens Leukemia, Myeloid, Acute blood Interaction[ targeting miR-148b ] CCK8//qRT-PCR//Flow Cytometry HOTAIRM1 expression was higher while miR-148b expression was lower in AML patients than in healthy controls.In summary, HOTAIRM1 was involved in the progression of AML through targeting miR-148b, shedding light on the biological function and molecular mechanism of HOTAIRM1 in AML. Yes HOTAIRM1 silencing and miR-148b overexpression both suppressed cell proliferation and induced apoptosis in AML cells. miR-148b was identified as a target of HOTAIRM1 in AML cells. Moreover, HOTAIRM1 knockdown inhibited proliferation and induced apoptosis in AML cells by negatively regulating miR-148b. 35520918 HOTAIRM1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues and cells Expression[highly expressed] qRT-PCR//MTT//Colony Formation Assay//Western Blot HOTAIRM1 expression was abnormally upregulated in PDAC tissues and cells when compared with the control samples, and was positively associated with the expression of KRAS gene mutation. Yes HOTAIRM1 knockdown attenuated cell proliferation by inducing cell cycle arrest at G0/G1 phase, promoted cell apoptosis, and inhibited cell migration in PDAC cells by regulating related-genes expression. 30613920 HOTAIRM1 LncRNA Homo sapiens Glioblastoma GBM tissues and cells Expression[highly expressed] qRT-PCR//ChIP HOTAIRM1 was abnormally up-regulated in GBM tissues and cells, and this up-regulation was correlated with grade malignancy in glioma patients. Yes HOTAIRM1 silencing caused tumor suppressive effects via inhibiting cell proliferation, migration and invasion, and inducing cell apoptosis. In vivo experiments showed knockdown of HOTAIRM1 lessened the tumor growth. 30376874 HOTAIRM1 LncRNA Homo sapiens Glioblastoma GBM tissue samples and cells interaction[SNAI2] ChIP//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay HOTAIRM1 was significantly overexpressed in GBM tissues and cells. Our results indicate a positive feedback loop between HOTAIRM1 and SNAI2, and suggest that the lncRNA HOTAIRM1 is a potential biomarker and therapeutic target in GBM. Yes HOTAIRM1 knockdown significantly weakened the migration and invasion by GBM cells. 33323548 HOTTIP LncRNA Homo sapiens Leukemia, Myeloid, Acute blood,cell lines Regulation[HOTTIP/microRNA-608/DDA1 axis] CCK8//qRT-PCR//Luciferase Report Assay//Flow Cytometry HOTTIP was highly expressed in AML-M5 patients than normal controls.HOTTIP expression was significantly up-regulated in AML cell lines U-937 and THP-1.Dual-luciferase reporter gene indicated that HOTTIP could bind to microRNA-608, which was lowly expressed in AML-M5 patients. Overexpression of microRNA-608 significantly inhibited the proliferative ability and cell cycle progression of U-937 and THP-1 cells. More importantly, microRNA-608 could partially reverse the regulatory effect of HOTTIP on AML cells. Meanwhile, DDA1 was verified as the target of microRNA-608. Subsequent experiments elucidated that DDA1 significantly accelerated the proliferation and cell cycle of AML cells. Yes Up-regulation of HOTTIP remarkably promoted the proliferative potential and cell cycle progression of AML cells. 31002141 HOTTIP LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction[c-Myc] CCK8//qRT-PCR//Wound Healing Assay//Western Blot HOTTIP was demonstrated to be upregulated in OS tissues and cell lines.HOTTIP promoted cell migration and invasion by upregulating c-Myc in OS. The positive feedback loop formed by HOTTIP and c-Myc may contribute to OS progression, and HOTTIP may act as a therapeutic target for OS. Yes knockdown of HOTTIP inhibited OS cell migration, invasion and EMT, and suppressed c-Myc expression. In addition, overexpression of c-Myc increased HOTTIP expression and enhanced OS cell migration and invasion. 31423232 HOTAIRM1 LncRNA Homo sapiens Thyroid Neoplasms TC cells and tissues interaction[HOTAIRM1/miR-148a/Wnt10 axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The pronounced upregulated expression of HOTAIRM1 was evident in TC cells and tissues, and was associated with TNM stage and lymph node metastasis.Taken together, these results suggest that miR‑148a and Wnt10b are downstream effectors of the HOTAIRM1 signaling pathway in TC. This HOTAIRM1/miR‑148a/Wnt10 axis may thus be amenable to therapeutic targeting in order to improve disease outcomes in patients with TC. The pronounced upregulated expression of HOTAIRM1 was evident in TC cells and tissues, and was associated with TNM stage and lymph node metastasis. Yes When HOTAIRM1 was knocked down, this inhibited the proliferative and invasive abilities of TPC?1 and BCPAP cells in vitro. 33650656 HOTTIP LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck exosomes Regulation( miR-19a-3p and miR-19b-3p/TLR5/NF-κB pathway) CCK8//qRT-PCR Accordingly, HOTTIP was found to be upregulated in M1-derived exosomes. A mechanism study further showed that M1 exosomes and HOTTIP activated the TLR5/NF-κB signaling pathway by competitively sponging miR-19a-3p and miR-19b-3p. Furthermore, cancer cells expressing HOTTIP were noted to induce the polarization of both local M1 and M2 macrophages; however, M1 exosomes were observed to reprogram local TAMs into M1 macrophages. Yes Therefore, the function of HOTTIP in cancer cells was explored, for which overexpression of HOTTIP was found to inhibit proliferation, migration and invasion but induced apoptosis of cancer cells in vitro. 35210436 HOXA11-AS LncRNA Mus musculus Parkinson Disease SH-SY5Y neuronal and microglia Interaction(FSTL1/NF-κB axis) qRT-PCR//Luciferase Report Assay//Western Blot Inhibition of HOXA11-AS protects mice against PD through repressing neuroinflammation and neuronal apoptosis through miR-124-3p-FSTL1-NF-κB axis. Yes Inhibition of HOXA11-AS protects mice against PD through repressing neuroinflammation and neuronal apoptosis through miR-124-3p-FSTL1-NF-κB axis. 33839699 HOXA11-AS LncRNA Mus musculus Atherosclerosis AS mice tissues, vascular endothelial cell Interaction(miR-515-5p/ROCK1 axis) Western Blot//Transfection//Flow Cytometry//RIP//qRT-PCR//MTT//Luciferase Report Assay Our data showed that HOXA11-AS was significantly up-regulated (P < 0.001), whereas miR-515-5p was dramatically down-regulated in AS mice tissues (P < 0.001) and ox-LDL-treated HUVECs (P < 0.01). Luciferase assay and RIP results confirmed that miR-515-5p is directly bound to HOXA11-AS and ROCK1. HOXA11-AS promoted ox-LDL-induced HUVECs injury by directly inhibiting miR-515-5p from increasing ROCK1 expression and subsequently decreasing the expression and phosphorylation of eNOS. MiR-515-5p mimics could partially reverse the effects of HOXA11-AS knockdown. Yes Ox-LDL could induce endothelial injuries by inhibiting cell proliferation (P < 0.001) and SOD synthesis (P < 0.001), promoting apoptosis (P < 0.01), ROS (P < 0.001), and MDA production (P < 0.001), increasing Bax (P < 0.001) and cleaved Caspase-3 (P < 0.001), and decreasing Bcl-2 (P < 0.001) and phosphorylated eNOS (P < 0.01). HOXA11-AS knockdown attenuated endothelial injuries via increasing eNOS phosphorylation. 35578440 HOXA10-AS LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(lncRNA HOXA10-AS/miR-6509-5p/YBX1 signaling pathway ) IHC//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//H&E Staining//Colony Formation Assay//EdU Staining//Transwell Assay LncRNA HOXA10-AS is identified to be highly expressed in GC using the ENCORI database. The targets of HOXA10-AS included miR-6509-5p and Y-box binding protein 1 (YBX1). Specifically, HOXA10-AS downregulated miR-6509-5p in GC. An increase of miR-6509-5p inhibited GC cell growth. Meanwhile, miR-6509-5p interacted with YBX1 in GC. Together, lncRNA HOXA10-AS potentially acted as an oncogene through the lncRNA HOXA10-AS/miR-6509-5p/YBX1 signaling pathway in GC. Kaplan-Meier plot analysis indicated that the survival rate of the patient is associated with the expression of lncRNA HOXA10-AS. Yes Interference of HOXA10-AS inhibited GC cell proliferation, migration, and invasion as well as facilitated GC apoptosis. 35521747 HOXA10-AS LncRNA Homo sapiens Nasopharyngeal carcinoma NPC cells Interaction(miR-582-3p/RAB31) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Colony Formation Assay//Transwell Assay Briefly, HOXA10-AS was highly expressed in NPC cells. Further, HOXA10-AS could bind to miR-582-3p by acting as a competing endogenous RNA. Besides, Ras-related protein Rab-31 (RAB31) was proven as the target gene of miR-582-3p. Additionally, E2F transcription factor 1 (E2F1) acted as a transcription factor to activate HOXA10-AS expression. In the final rescue assays, we observed that the effect of HOXA10-AS depletion on NPC cell growth could be fully reversed by RAB31 overexpression or miR-582-3p inhibition. Yes HOXA10-AS down-regulation restrained NPC cell proliferation and migration. 35072529 HOXA10-AS LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer cell lines Interaction( HOXA10-AS/miR-340-3p/HTR1D ceRNA axis) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Lessened level of lncRNA HOXA10-AS reduced the sponging of miR-340-3p, resulting in an increase of miR-340-3p and a subsequent decrease of HTR1D to ultimately suppress the malignant biological behaviors of cancer. These data illustrated that the HOXA10-AS/miR-340-3p/HTR1D ceRNA axis acted a crucial part in the malignant biological behavior of pancreatic cancer in an AKT-dependent manner. Yes Lessened level of lncRNA HOXA10-AS reduced the sponging of miR-340-3p, resulting in an increase of miR-340-3p and a subsequent decrease of HTR1D to ultimately suppress the malignant biological behaviors of cancer. 35813473 HOXA10-AS LncRNA Homo sapiens Mouth Neoplasms cancer cells Regulation(TP63) In Vivo Experiment//Wound Healing Assay//qRT-PCR//RIP//MTT//Colony Formation Assay//Transwell Assay Recent transcriptomic profiling has recognized a tumor-biased expressed lncRNA, the HOXA10-AS transcript, whose expression is associated with patient survival. In this study, we identify that HOXA10-AS serves as a modular scaffold for TP63 mRNA processing and that such involvement regulates cancer growth. Recent transcriptomic profiling has recognized a tumor-biased expressed lncRNA, the HOXA10-AS transcript, whose expression is associated with patient survival. Yes Functional cell-based assays show that the HOXA10-AS transcript is essential in the regulation of oral cancer growth and metastasis. 35858923 HOXA10-AS LncRNA Homo sapiens Glioma glioma cells Regulation Cell Proliferation Assay//qRT-PCR//RNA-seq//Flow Cytometry In low-grade gliomas, HOXA10-AS activation is a robust marker of poor prognosis that complements IDH1/2 mutations, as validated in another retrospective cohort, and correlates with developmental pathways in tumor transcriptomes. Loss- and gain-of-function studies in patient-derived glioma cells, organoids, and xenograft models identify HOXA10-AS as a potent onco-lncRNA that regulates cell proliferation, contact inhibition, invasion, Hippo signaling, and mitotic and neuro-developmental pathways. Yes Loss- and gain-of-function studies in patient-derived glioma cells, organoids, and xenograft models identify HOXA10-AS as a potent onco-lncRNA that regulates cell proliferation, contact inhibition, invasion, Hippo signaling, and mitotic and neuro-developmental pathways. 34686327 HOXA10 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC stem cells and tumor tissues Interaction(microRNA-29a/MCL-1/phosphatidyl inositol 3-kinase/protein kinase B axis) CCK8//qRT-PCR HOXA10-AS and MCL-1 were highly expressed while miR-29a was poorly expressed in the collected tumor tissues and the extracted OSCC stem cells. In addition, HOXA-10-AS and MCL-1 were found to activate the phosphatidyl inositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway. . High expression of HOXA10-AS and MCL-1, while poor expression of miR-29a was relevant to poor prognosis in patients. Yes Silencing of HOXA10-AS suppressed proliferation and tumor sphere formation ability of stem cells, and it reduced growth and metastasis of tumors in animals. 33831733 HOTTIP LncRNA Homo sapiens Breast Neoplasms breast cancer stem cells regulation[miR-148a-3p/WNT1 pathway] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot In this study, we found that HOTTIP was markedly up-regulated in BCSCs and had a positive correlation with breast cancer progression.Our study is the first to report that HOTTIP regulates the CSC-like properties of BCSCs by as a molecular sponge for miR-148a-3p to increase WNT1 expression, offering a new target for breast cancer therapy. Yes Functional studies revealed that overexpression of HOTTIP markedly promoted cell clonogenicity, increased the expression of the stem cell markers, OCT4 and SOX2, and decreased the expression of the differentiation markers, CK14 and CK18, in breast cancer cells. 32307830 HOTTIP LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR Our results found that HOTTIP was upregulated in human primary CRC tissues. Yes Knockdown of HOTTIP inhibited CRC cell proliferation, migration, and invasion. 31945724 HOTTIP LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[DKK1 ] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay Here, we found that HOTTIP level was significantly higher in CRC than in corresponding adjacent normal tissues.Mechanistic analyses indicated that HOTTIP regulates CRC cell metastasis partly through the downregulation of tumor suppressor DKK1 expression. Collectively, our results suggest that tumor expression of lncRNA HOTTIP plays an important role in CRC metastasis. HOTTIP may serve as a candidate biomarker in this disease. Here, we found that HOTTIP level was significantly higher in CRC than in corresponding adjacent normal tissues, and patients with a larger tumor size, advanced pathological stage, or distant metastasis had higher HOTTIP expression. Yes Moreover, silencing HOTTIP expression by siRNA or shRNA could inhibit CRC cell migration and invasion in vitro and in vivo, whereas HOTTIP overexpression promoted cell metastasis, as documented in the SW480 cell lines. 30229808 HOTTIP LncRNA Homo sapiens Thyroid Cancer, Papillary patients with PTC Expression[highly expressed] qRT-PCR PAPAS was downregulated, while the lncRNA HOXA transcript at the distal tip (HOTTIP) was upregulated in patients with PTC. PAPAS expression level decreased, while HOTTIP expression level increased with the increase of clinical staging. Yes PAPAS overexpression led to the inhibition of cell proliferation, while HOTTIP overexpression increased proliferation of PTC cells, and HOTTIP overexpression decreased the effects of PAPAS overexpression. 32194727 HOTTIP LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines Regulation[PI3K/Akt/Atg13 signaling pathway] Wound Healing Assay//qPCR//CCK8//Luciferase Report Assay//Transwell Assay The results showed that HOTTIP expression was significantly upregulated in the RCC tissues and cell lines.Further research revealed that HOTTIP modification could affect RCC cell autophagy via the PI3K/Akt/Atg13 signaling pathway. The results showed that HOTTIP expression was significantly upregulated in the RCC tissues and cell lines, and it was closely associated with TNM stage, histological grade, lymph node metastasis and patient prognosis. Yes The in vitro and in vivo assays indicated that HOTTIP silencing inhibited RCC cell proliferation, migration and invasion and induced autophagy, and 3-MA (an autophagy inhibitor) reversed these effects. 30511250 HOTTIP LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissue Regulation[Wnt/β-catenin signaling] qRT-PCR In the present study, our results observed that lncRNA HOTTIP expression levels were notably higher in ovarian cancer tissue samples compared to adjacent normal tissue samples. Furthermore, we demonstrated that inhibition of lncRNA HOTTIP suppressed Wnt/β-catenin signaling by downregulating β-catenin expression. Thus, these results suggest that aberrant HOTTIP expression level could serve as a promising biomarker for monitoring ovarian cancer and potential target of ovarian cancer treatment. Increased lncRNA HOTTIP expression levels were significantly associated with advanced FIGO stage and lymph node metastasis of ovarian cancer patients. Survival plots analysis results showed high lncRNA HOTTIP expression levels in ovarian cancer patients showed a poor prognosis compared to patients with low lncRNA HOTTIP expression levels. Yes Function assays showed that lncRNA HOTTIP knockdown in ovarian cancer cells decreased cell proliferation and cell invasion capacities. 30452402 HOTTIP LncRNA Homo sapiens Ovarian Neoplasms regulation[MEK/ERK pathway] Wound Healing Assay//Flow Cytometry//qRT-PCR//Colony Formation Assay//Transwell Assay In conclusion, HOTTIP was demonstrated to promote the proliferation, migration and invasion of OC cells by activating the MEK/ERK pathway. Yes The results demonstrated that knockdown of HOTTIP in OC cells significantly reduced the phosphorylation levels of MEK and ERK, inhibited the proliferation and invasion of OC cells and promoted their apoptosis. 33000231 HOTTIP LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer cell lines and clinical tissues regulation[miR-615-3p/SMARCE1 pathway] qRT-PCR In this study, we demonstrated overexpression of HOTTIP in ovarian cancer cell lines and clinical tissues. In summary, lncRNA HOTTIP promotes the growth and metastatic phenotypes of ovarian cancer via regulating miR-615-3p/SMARCE1 pathway. Further, we showed that higher level of HOTTIP was associated with poor survival of ovarian cancer patients. Yes Notably, HOTTIP silencing restrained proliferation, migration, and invasiveness of ovarian carcinoma cells. 32783402 HOTTIP LncRNA Homo sapiens Ovarian Neoplasms OC tissue samples and cell lines Interaction(miR-148a-3p/AKT2 axis ) qRT-PCR//Colony Formation Assay//Western Blot The expression of HOTTIP was significantly upregulated in OC tissue samples and cell lines. In addition, HOTTIP increased AKT2 expression by negatively regulating miR-148a-3p and then inhibited ASK1/JNK signaling. Further rescue experiments revealed that downregulation of miR-148a-3p and overexpression of AKT2 obviously diminished the effects of HOTTIP downregulation in OC cells. Yes The silencing of HOTTIP led to the inhibition of cell proliferation and NLRP1 inflammasome-mediated pyroptosis. 33710684 HOTTIP LncRNA Homo sapiens Ovarian Neoplasms OCC tissues and cells Interaction(HIF-1α ) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//ELISA//Transwell Assay HOTTIP was highly expressed in OCC. RNA pull-down indicated a direct interaction between HIF-1α and HOTTIP. Yes After HOTTIP knockdown, HIF-1α expression and VEGF concentration in OCC were decreased. Cell migration, invasion, and cell viability were decreased. Cell apoptosis rate and G0/G1 phase cells were increased. 36699159 HOTTIP LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues,cell lines Expression[highly expressed] qRT-PCR Furthermore, it was proved that HOTTIP was upregulated in HNSCC cell lines and cancerous tissues compared with corresponding normal cell lines and normal tissues. Yes Functional assessment analysis revealed that HOTTIP might play a key role in the oncogenesis and progression of HNSCC. 31032351 HOTAIRM1 LncRNA Homo sapiens Glioblastoma glioblastoma patients Regulation(TGM2) In Vivo Experiment//Western Blot//qRT-PCR//RNA-seq//Colony Formation Assay We identified HOTAIRM1 as a candidate lncRNA whose up-regulation is significantly associated with shorter survival of glioblastoma patients, independent from IDH mutation and MGMT promoter methylation. HOTAIRM1 knock-down decreased expression of transglutaminase 2 (TGM2), a candidate protein implicated in mitochondrial function, and knock-down of TGM2 mimicked the phenotype of HOTAIRM1 down-regulation in glioblastoma cells. Yes Glioblastoma cell line models uniformly showed reduced cell viability, decreased invasive growth and diminished colony formation capacity upon HOTAIRM1 down-regulation. Integrated proteogenomic analyses revealed impaired mitochondrial function and determination of reactive oxygen species (ROS) levels confirmed increased ROS levels upon HOTAIRM1 knock-down. 34584066 HOTAIRM1 LncRNA Homo sapiens Thyroid Neoplasms PTC tissues regulation[miR-144] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining In this study, we identified a long noncoding RNA (lncRNA) HOTAIRM1, whose encoding gene was amplified and expression was upregulated in ATC compared with papillary thyroid cancer and normal thyroid. Altogether, these findings identified a genomic copy number amplified and highly expressed lncRNA HOTAIRM1, which exerted oncogenic roles via repressing miR-144 biogenesis in ATC. Yes Functional assays revealed that HOTAIRM1 promoted proliferation, inhibited apoptosis, and promoted migration and invasion of ATC cells in vitro, and promoted ATC tumour growth and metastasis in vivo. 32951513 HOTAIR LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-6888-3p/SYK ) CCK8//qRT-PCR//Western Blot We found that HOTAIR and SYK were highly expressed in OS, whereas miR-6888-3p expression was low. Mechanistically, these results suggest that the HOTAIR sponge, miR-6888-3p, regulates SYK expression. Yes In addition, downregulation of HOTAIR or SYK significantly inhibited the growth and migration of OS cells and the PI3K/AKT pathway, both in vitro and in vivo. Additionally, downregulation of miR-6888-3p promoted the proliferation and migration of OS cells and activated the PI3K/AKT pathway. 35435107 HOTAIR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines Regulation[miR-217/DACH1 signaling pathway] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot HOTAIR was up-regulated and miR-217 was down-regulated in NSCLC cell lines.HOTAIR was up-regulated in NSCLC cell and regulates the proliferation, migration, invasion through the miR-217/DACH1 signaling pathway. It provides a novel potential treatment strategy for NSCLC. Yes Silencing of HOTAIR significantly repressed cell proliferation and inhibited cell migration and invasion in H1299 and A549 cells by facilitating miR-217 expression. 30720199 HOTAIR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells and tissues Interaction(CCL22) qRT-PCR//Transwell Assay In conclusion, this study suggests that HOTAIR may promote proliferation, migration and invasion of the NSCLC cells by inhibiting CCL22 expression, which may play a key role in NSCLC cell immunity. Yes In conclusion, this study suggests that HOTAIR may promote proliferation, migration and invasion of the NSCLC cells by inhibiting CCL22 expression, which may play a key role in NSCLC cell immunity. 35176085 HOTAIR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and the CRC cell lines Regulation[p21] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Transwell Assay HOTAIR was found to be expressed at high levels, while p21 was determined to be at a low level among both the CRC tissues and the CRC cell lines. The principal findings demonstrated that down-regulation of HOTAIR elicits an inhibitory effect on proliferation, invasion, and migration, while promoting the apoptosis of CRC cells through the up-regulation of p21. The expressions of HOTAIR and p21 were determined to be related to lymph node metastasis, tumor node metastasis, Dukes staging, distant metastases, histological types, and the degree of differentiation. Yes Cells transfected with HOTAIR siRNA displayed inhibited rates of proliferation, invasion, and migration, as well as decreased cyclin E and CDK2, while apoptosis and p21 were increased. 29808247 HOTAIR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Interaction[recruiting EZH2] qRT-PCR In this study, Hotair was found to be upregulated in colorectal cancer (CRC) cells and clinical specimens. In conclusion, Hotair mediated tumorigenesis via recruiting EZH2, which might shed light on the development of a novel therapeutic approach for patients with CRC. Yes Further investigation showed that knockdown of Hotair dramatically suppressed cell proliferation and colony formation, suggesting that Hotair may stimulate tumorigenesis of CRC. 30362162 HOTAIR LncRNA Homo sapiens Colorectal Neoplasms tissue and cell lines Interaction(SNAIL/HNF4α ) CCK8//qRT-PCR//Western Blot HOTAIR was highly expressed in both tissue and cell lines of colorectal cancer, indicated a regulatory function in colorectal cancer.We further found that HOTAIR suppressed HNF4α via recruiting SNAIL, and the overexpression of HNF4α inhibited cell viability, migration, invasion and EMT of colorectal cancer cells. We demonstrated that HOTAIR regulates the level of HNF4α via recruiting SNAIL, knocking down HOTAIR repressed the cell viability and metestasis of colorectal cancer cell line in vitro, and suppressed the tomorgenesis and migration/invasion of colorectal cancer in vivo. Yes Knock-down of HOTAIR suppressed cell viability, migration, invasion and epithelial-mesenchymal transition (EMT) of colorectal cancer cells in vitro, and inhibited the growth and metastasis of colorectal tumor in nude mice. 33588137 HOTAIR LncRNA Homo sapiens Colorectal Neoplasms tumor cell Interaction(HOTAIR/miR-211-5p/FLT-1 axis ) RNA Pull-Down//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Invasion Assay//Transwell Assay We found that HOTAIR was highly expressed and predicted poor prognosis survival in CRC. Downregulation of HOTAIR repressed tumor malignant behaviors and cancer stemness. Mechanistically, HOTAIR facilitated the expression of the microRNA (miR)-211-5p target gene fms-like tyrosine kinase-1 (FLT-1), thereby modulating cancer stem cell (CSC) properties in CRC. We conclude that HOTAIR/miR-211-5p/FLT-1 axis contributes to CRC cancer stemness. We found that HOTAIR was highly expressed and predicted poor prognosis survival in CRC. Yes Downregulation of HOTAIR repressed tumor malignant behaviors and cancer stemness. 34470574 HOTAIR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-203a-3p/ Wnt/β-catenin signaling ) qRT-PCR//Western Blot The expressions of HOTAIR were upregulated in CRC tissue tissues compared to adjacent control tissues. We also found HOTAIR was downregulated by miR-203a-3p in CRC cell lines. We also determined that β-catenin and GRG5 were inhibitory targets of miR-203a-3p, and that Wnt/β-catenin signaling was inhibited by both HOTAIR knockdown and miR-203a-3p overexpression. Significantly, we found that increased expression of miR-203a-3p is essential for cell proliferation repression, chemoresistance reduction, and Wnt/β-catenin signaling inhibition induced by HOTAIR knockdown. Yes Both HOTAIR knockdown and miR-203a-3p overexpression in CRC cell lines led to inhibited cell proliferation and reduced chemoresistance. 29680837 HOTAIR LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Interaction[down-regulating miRNA-34a] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining QRT-PCR results showed that HOTAIR expression in colon cancer was significantly higher than that in normal tissues. QRT-PCR results showed that mRNA levels of miR-34a and HOTAIR in colon cancer tissues were negatively correlated. Besides, luciferase reporter gene assay revealed that overexpression of miR-34a significantly attenuated the luciferase activity of the wild-type HOTAIR vector group without attenuating the mutant HOTAIR vector group (p>0.05) In addition, the recovery experiment also found a mutual regulation between HOTAIR and miR-34a, together they could affect the malignant progression of colon cancer. The incidence of distant metastasis was higher in patients with high expression of HOTAIR while their survival rate was lower than that of patients with low HOTAIR expression. Yes Meanwhile, cell proliferation, invasion as well as migration ability of the cells in HOTAIR knockdown group was significantly decreased than those in the negative control group. 31298326 HOTAIR LncRNA Homo sapiens Colonic Neoplasms Interaction[regulating IGF2BP2] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay//IF We determined the expressions of HOTAIR, IGF2BP2, E-cadherin, and vimentin. Meanwhile, cell growth, cycle and apoptosis, migration, and invasion were assayed. LoVo cells were transplanted into nude mice, and tumor formation and microvessel density were evaluated. LncRNA HOTAIR positively regulated IGF2BP2. Besides, the expressions of HOTAIR and E-cadherin and the apoptosis were increased, while the expressions of IGF2BP2 and vimentin, the growth, invasion and migration of LoVo cells, the average tumor weight, and microvessel density value were decreased. Of importance, overexpressed IGF2BP2 could reverse the above impacts. Yes Taken together, the current study indicates that silencing of HOTAIR could inhibit the invasion, proliferation, and migration, and promote apoptosis of colon cancer LoVo cells through suppressing IGF2BP2 and the epithelial-mesenchymal transition. 30335892 HOTAIR LncRNA Homo sapiens Thyroid Cancer, Papillary PTC cells and tissues regulation[miR-488-5p/NUP205 Axis] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay It was demonstrated that high expression of HOTAIR in PTC cells (BCPAP) and tissues resulted in fast tumor growth and poor survival time of the PTC-bearing mice models.HOTAIR promoted the growth, migration, and invasion of papillary thyroid carcinoma mainly through regulating the miR-488-5p/NUP205 axis. Yes Moreover, overexpression of HOTAIR leaded to markedly enhanced proliferation, migration, and invasion of BCPAP cells. 33107391 HOTAIR LncRNA Homo sapiens Carcinoma, Renal Cell cell lines Interaction(miR-126/EGFL7 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//IHC//Transwell Assay These findings suggest that lncRNA HOTAIR regulate RCC angiogenesis through miR-126/EGFL7 axis and provide a new perspective on the molecular pathways of angiogenesis in RCC development, which might be potential therapeutic targets for RCC treatment. Yes HOTAIR knockdown and miR-126 overexpression suppressed the proliferation, migration, and angiogenesis of RCC cells. HOTAIR regulated EGFL7 expression by competitively binding to miR-126.HOTAIR significantly suppressed the RCC tumor progression and lung metastasis in vivo. 33502949 HOTAIR LncRNA Homo sapiens Carcinoma, Renal Cell RCC cells Expression(highly expressed) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay We found that the high expression of lncRNA HOTAIR in RCC is associated with poor prognosis. Moreover, HOTAIR and AR form a feedback loop to promote the expression of each other. Interestingly, we also found that in RCC, HOTAIR is associated with the Hedgehog pathway, especially GLI2, via bioinformatics analysis. Furthermore, HOTAIR promotes GLI2 expression in the presence of AR. Mechanistically, HOTAIR interacts with AR and they cooperatively bind to GLI2 promoter and increase its transcription activity. We found that the high expression of lncRNA HOTAIR in RCC is associated with poor prognosis. Yes We further confirmed how HOTAIR-AR axis regulates GLI2 expression by analyzing its function in RCC cells and found that HOTAIR and AR synergistically enhanced the expression of GLI2 downstream genes, such as VEGFA, PDGFA, and cancer stem cell transcription factors, and promoted tumor angiogenesis and cancer stemness in RCC cells both in vitro and in tumor xenografts. 33157157 HOTAIR LncRNA Homo sapiens Osteoarthritis cartilage tissues regulation[inhibiting WIF-1 expression and activating Wnt pathway] CCK8//qRT-PCR//Colony Formation Assay//Tunel HOTAIR expression was greatly elevated in osteoarthritic compared to normal chondrocytes. Activation of Wnt/β-catenin signalling by HOTAIR through WIF-1 repression in osteoarthritic chondrocytes increases catabolic gene expression and promotes cartilage degradation. Yes Silencing and over-expression of HOTAIR in SW1353 cells respectively reduced and increased the expression of genes associated with cartilage degradation in OA. 32650720 HOTAIR LncRNA Homo sapiens Osteoarthritis OA cartilages and LPS-stimulated CHON-001 chondrocytes Interaction(miR-1277-5p/SGTB axis) Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//ELISA HOTAIR and SGTB were up-regulated, while miR-1277-5p was down-regulated in OA cartilages and LPS-stimulated CHON-001 chondrocytes.HOTAIR aggravated chondrocyte apoptosis and inflammation in OA via regulating miR-1277-5p/SGTB pathway. Yes HOTAIR depletion inhibited LPS-induced apoptosis and inflammation in chondrocytes. Moreover, down-regulation of HOTAIR attenuated LPS-triggered chondrocyte apoptosis and inflammation via sponging miR-1277-5p. Also, miR-1277-5p repressed LPS-induced chondrocyte apoptosis and inflammation by targeting SGTB. 33721916 HOTAIR LncRNA Homo sapiens Osteoarthritis Chondrocytes Interaction(miR-107/CXCL12 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis HOTAIR expression was enhanced, and miR-107 level was reduced in OA cartilage samples. HOTAIR overexpression inhibited cell proliferation, but induced cell apoptosis and ECM degradation in chondrocytes. HOTAIR knockdown caused an opposite effect. MiR-107 was sponged and inhibited via HOTAIR, and knockdown of miR-107 mitigated the effect of HOTAIR silence on chondrocyte injury. CXCL12 was targeted by miR-107. CXCL12 overexpression attenuated the roles of miR-107 overexpression or HOTAIR knockdown in the proliferation, apoptosis and ECM degradation. CXCL12 expression was decreased by HOTAIR silence, and restored by knockdown of miR-107. Yes HOTAIR overexpression inhibited cell proliferation, but induced cell apoptosis and ECM degradation in chondrocytes. HOTAIR knockdown caused an opposite effect. 34183035 HOTAIR LncRNA Homo sapiens Carcinoma, Hepatocellular interaction[miR-122] CCK8//qRT-PCR//ChIP//Western Blot In this study, we found that HOTAIR was highly expressed whereas miR-122 was suppressed in HCC, and HOTAIR negatively regulated miR-122 expression in HCC cells. Mechanistically, a CpG island was located in the miR-122 promoter region. HOTAIR epigenetically suppressed miR-122 expression via DNMTs-mediated DNA methylation. Yes Furthermore, knockdown of HOTAIR dramatically inhibited HCC cell proliferation and induced cell cycle arrest in vitro and suppressed tumorigenicity in vivo by upregulating miR-122 expression. 30195653 HOTAIR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[HOTAIR/miR-214-3p/FLOT1 axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay HOTAIR and FLOT1 expression were significantly up-regulated, whereas miR-214-3p was obviously down-regulated. Otherwise, HOTAIR regulated FLOT1 expression through targeting miR-214-3p in HCC cells. Simultaneously, low HOTAIR expression inhibited FLOT1 expression by up-regulating miR-214-3p, which suppressed tumor growth in vivo. Yes Also, down-regulation of HOTAIR and FLOT1 as well as up-regulation of miR-214-3p inhibited cell proliferation, invasion, and migration. Intriguingly, the effects of miR-214-3p overexpression on HCC cells were rescued by high expression of HOTAIR. 31933720 HOTAIR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-526b-3p/DHX33 axis) qRT-PCR The levels of HOTAIR and DHX33 were increased in HCC tissues and cells. Interestingly, miR-526b-3p could directly bind to HOTAIR, and DHX33 was a direct target of miR-526b-3p. Additionally, interference of HOTAIR restrained the tumor growth by upregulating miR-526b-3p and downregulating DHX33 in vivo. Yes Knockdown of either HOTAIR or DHX33 suppressed proliferation, migration and invasion but increased apoptosis in HCC cells. Moreover, DHX33 overexpression reversed the suppressive effect of HOTAIR knockdown on progression of HCC cells. 33843021 HOTAIR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissue samples and cell lines regulation[HOTAIR-miR-326-MTA2 axis] qRT-PCR Our results showed that HOTAIR was highly expressed both in OSCC tissue samples and cell lines compared with corresponding normal oral mucosa tissues and human oral keratinocytes.The HOTAIR-miR-326-MTA2 axis may contribute to a better understanding of OSCC pathogenesis and be a potential therapeutic target for OSCC. Its overexpression was positively correlated with TNM (tumor-node-metastases) stage, histological grade, and regional lymph node metastasis. Yes The knockdown of HOTAIR by short hairpin RNA significantly decreased the migration, invasion, and epithelial-mesenchymal transition of OSCC cells in vitro. 31995261 HOTAIR LncRNA Homo sapiens pancreatic adenocarcinoma tumor and adjacent healthy tissues Interaction[upregulating HK2] CCK8//qRT-PCR//Western Blot the expression level of HOTAIR was significantly upregulated in tumor tissues compared with adjacent healthy tissues (P<0.05) in 46/51 patients. Therefore, it was concluded that the lncRNA HOTAIR may promote cancer cell energy metabolism in pancreatic adenocarcinoma by upregulating HK2. Yes HOTAIR and HK2 overexpression led to the promotion of tumor cell proliferation. HOTAIR overexpression increased lactate production, glucose uptake and ATP production. 31452722 HOTAIR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung interaction[miR-149-5p] Flow Cytometry//Wound Healing Assay//Luciferase Report Assay//Transwell Assay In summary, we find that HOTAIR can regulate HNRNPA1 expression through a ceRNA mechanism by sequester miR-149-5p, which post-transcriptionally targets HNRNPA1, thus promoting lung cancer progression. Yes LncRNA HOTAIR and HNRNPA1 are reported to play an oncogenic role in non-small cell lung cancer, and the overexpression of HNRNPA1 is shown to promote the proliferation of lung adenocarcinoma cells. 33102210 HOTAIR LncRNA Homo sapiens Breast Neoplasms MCF-7 cells Regulation(PI3K/AKT/mTOR signaling pathway) CCK8 The results revealed that HOX antisense intergenic RNA knockdown can downregulate the expression of PI3K, AKT, and mTOR RNAs compared to negative control in MCF-7 cells. In addition, the proliferation of breast cancer cells was significantly reduced following the HOX antisense intergenic RNA silencing. Yes In addition, the proliferation of breast cancer cells was significantly reduced following the HOX antisense intergenic RNA silencing. 35649067 HOTAIR LncRNA Homo sapiens Breast Neoplasms hepatocellular carcinoma cells Interaction( miR-130a-3p/Suv39H1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//CCK8//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay HOTAIR functioned as a ceRNA by sponging miR-130a-3p and subsequently promoted Suv39H1-mediated AKT/mTOR signaling. Suv39H1 restoration abolished the effects of HOTAIR knockdown on BC cell growth and metastasis. HOTAIR facilitated the Suv39H1-mediated AKT/mTOR pathway by acting as a molecular sponge of miR-130a-3p. Yes High HOTAIR expression facilitated BC cell growth and metastasis. 35619625 HOTAIRM1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues regulation[HOTAIRM1/miR-107/TDG axis] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this study, we used quantitative reverse transcription PCR (qRT-PCR) to show that HOTAIRM1 was significantly downregulated in PTC tissues and low HOTAIRM1 expression levels were associated with lymph node metastasis and advanced TNM stage. In conclusion, we validated HOTAIRM1 as a novel tumor-suppressor lncRNA in PTC and proposed that the HOTAIRM1/miR-107/TDG axis may serve as a therapeutic target for PTC. In this study, we used quantitative reverse transcription PCR (qRT-PCR) to show that HOTAIRM1 was significantly downregulated in PTC tissues and low HOTAIRM1 expression levels were associated with lymph node metastasis and advanced TNM stage. Yes Overexpression of HOTAIRM1 was found to inhibit PTC cell proliferation, invasion, and migration in vitro. 32269214 HOTAIRM1 LncRNA Homo sapiens Adenocarcinoma of Lung ADC tissues regulation[miR-498/WWOX Axis] CCK8//qRT-PCR//EdU Staining HOTAIRM1 expression was considerably decreased in ADC tissues.HOTAIRM1 suppressed the proliferation and invasion of ADC cells via the modulation of miR-498/WWOX axis. Yes The knockdown of HOTAIRM1 promoted the cell cycle, growth, and invasion of ADC. 32606933 HOTAIRM1 LncRNA Homo sapiens Prostatic Neoplasms cell lines regulation[suppressing the Wnt pathway] Flow Cytometry//qRT-PCR//MTT//Western Blot HOTAIRM1 was overexpressed in PC3 cells compared with RWPE-1 cells.Overall, HOTAIRM1 silencing in PC3 cells inhibited the proliferative ability and promoted the apoptosis of PCa cells by suppressing the Wnt pathway, thereby inhibiting the progression of PCa. Yes Reducing HOTAIRM1 alleviated cell proliferation and increased apoptosis of PC3 cells so that the expression of pro-apoptotic agents such as Bad and Bax was significantly increased, while that of Bid and Bcl-2 (anti-apoptotic) was decreased. 33368390 HOTAIRM1 LncRNA Homo sapiens Thyroid Carcinoma, Anaplastic ATC of papillary thyroid cancer Interaction(miR-144 / MET/AKT signalling) In Vivo Experiment//Western Blot//qPCR//Luciferase Report Assay//Invasion Assay In this study, we identified a long noncoding RNA (lncRNA) HOTAIRM1, whose encoding gene was amplified and expression was upregulated in ATC compared with papillary thyroid cancer and normal thyroid. HOTAIRM1 was found to bind ILF3, repress the binding between ILF3 and precursor miR-144 (pre-miR-144), block the effects of ILF3 on stabilizing pre-miR-144, and therefore downregulate pre-miR-144. Intriguingly, HOTAIRM1 was also found to directly bind primary miR-144 (pri-miR-144), repress the binding between pri-miR-144 and DROSHA, block the processing of pri-miR-144 by DROSHA, and therefore upregulate pri-miR-144 and downregulate pre-miR-144. Increased genomic copy number and expression of HOTAIRM1 were both correlated with poor survival of ATC patients. Yes Functional assays revealed that HOTAIRM1 promoted proliferation, inhibited apoptosis, and promoted migration and invasion of ATC cells in vitro, and promoted ATC tumour growth and metastasis in vivo. 32951513 HOTAIRM1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues Regulation[HOTAIRM1/HOXA1 Axis] qRT-PCR//Western Blot The expression levels of HOTAIRM1 and HOXA1 were significantly upregulated in type I EC tissues.Moreover, we identified that HOTAIRM1 acts as a regulator for the expression of the HOXA1 gene in type I EC cells. As an oncogene, HOXA1 silencing also caused suppressive effects on tumors by inhibiting cell proliferation, migration and invasion. In addition, we also confirmed the role of HOTAIRM1 and HOXA1 in promoting tumor growth in vivo. Yes Knockdown of HOTAIRM1 significantly inhibited cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in vitro, while the over-expression of HOTAIRM1 led to the opposite effects. 31853186 HOTAIRM1 LncRNA Homo sapiens Liver Neoplasms cells interaction[miR-125b] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The expression level of RIZ1 and miR-125b was upregulated, and HOTAIRM1 was downregulated in liver cancer cells. For the first time, we found that RIZ1 was upregulated in liver cancer cells and RIZ1-mediated H3K9me1 enrichment on the HOTAIRM1 promoter regulated the growth and metastasis of liver cancer cells by targeting miR-125b, which could further accelerate tumor proliferation, migration and invasion. Yes Transwell and CCK-8 assay showed that RIZ1 expression is associated with the proliferation, invasion and migration of liver cancer cells, silencing of RIZ1 inhibited cell proliferation, migration, and invasion in HEPG2 and HCC-LM3 cells. 32964965 Hotairm1 LncRNA Mus musculus Sepsis a mouse model of sepsis Regulation( Notch/Hes1 signaling) RNA Pull-Down//Northern Blot//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Microarray//ELISA//ChIP Using a mouse model of sepsis, we found that the long noncoding RNA HOTAIRM1 (HOXA transcript antisense RNA myeloid-specific 1) was highly expressed in mice during the late phase of sepsis. The upregulation of HOTAIRM1 was induced by Notch/Hes1 activation and, moreover, was critical for the formation of an immunosuppressive microenvironment. Further mechanistic studies identified HOXA1 as a key transcription factor targeted by HOTAIRM1 to regulate PD-L1 expression in lung alveolar epithelial cells. These results implicated that the Notch/Hes1/HOTAIRM1/HOXA1/PD-L1 axis was critical for sepsis-induced immunosuppression and could be a potential target for sepsis therapies. Yes HOTAIRM1 induced T cell exhaustion by increasing the percentage of PD-1+ T cells and regulatory T cells, accompanied by elevated PD-L1. Blockade of either Notch/Hes1 signaling or HOTAIRM1 inhibited T cell exhaustion in late sepsis, having alleviated lung injury and improved survival of mice. 35022270 HOTAIR LncRNA Homo sapiens Stomach Neoplasms GC tissues ,cell lines Regulation[PI3K/ATK Signaling Pathway] Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay The levels of HOTAIR and KLF12 were significantly upregulated and the level of miR-618 was strikingly downregulated in GC tissues and cells.miR-618 inhibited GC progression and PI3K/ATK signaling pathway by targeting KLF12. Mechanistically, HOTAIR modulated KLF12 expression by sponging miR-618 in GC cells. Yes HOTAIR silencing blocked GC progression and PI3K/ATK signaling pathway by sponging miR-618 and also restrained xenograft tumor growth in vivo. 31391030 HOTAIR LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Regulation[miR-217-GPC5 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Microarray//Colony Formation Assay//Transwell Assay We observed that Hotair was frequently up-regulated in GC tissues and cell lines, and high Hotair level was positively correlated with poor prognosis in GC patients. MiR-217 was decreased while GCP5 was increased in GC cells. Hotair negatively regulated the expression of miR-217 in GC while miR-217 targeted GCP5 to down-regulate its expression. Hotair promoted GC development by promoting GCP5 expression via sponging miR-217. Yes Knockdown of Hotair inhibited GC cells' viability, migration, invasion, Epithelial mesenchymal transition process. 30557546 HOTAIR LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[NF-κB pathway] qRT-PCR The results showed that the expression of HOTAIR was higher in gastric cancer than in normal tissues, but reached the highest level in atrophic gastritis, suggesting that HOTAIR may be involved in the molecular process of nonresolving inflammation. Then tumor necrosis factor-α-induced protein-8 like-2 (TIPE2), a known gene associated with nonresolving inflammation, was overexpressed and the results showed that the promotion in TIPE2 expression triggered HOTAIR reduction, this result was further verified by microarray analysis and TIPE2 knockout mice. Subsequently, the data obtained from HOTAIR knockdown experiment showed that it significantly enhanced colony forming capability and inhibited p27 expression in AGS cells. Furthermore, deletion constructs and luciferase-based activity assays indicated that the -475 to -443bp region of HOTAIR promoter contained a crucial regulatory element. Transcription factor prediction with software TRANSFAC revealed that nuclear factor-κB signaling protein p65 had a binding site in this region and might have roles in HOTAIR expression. The binding of phosphor-p65 to HOTAIR promoter was verified by chromatin immunoprecipitation, and succeeding experiment results demonstrated that p65 reduction by p65 small interfering RNA and TIPE2 overexpression also decreased HOTAIR expression. Conclusively, our results suggest that HOTAIR was associated with nonresolving inflammation, and its expression is regulated by p65. Yes ubsequently, the data obtained from HOTAIR knockdown experiment showed that it significantly enhanced colony forming capability and inhibited p27 expression in AGS cells. 30635945 HOTAIR LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Regulation[miR-126/CXCR4 axis ] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay HOTAIR was highly expressed in gastric cancer tissues and several gastric cancer cell lines. Our study demonstrated that high HOTAIR expression promote proliferation and metastasis in gastric cancer via miR-126/CXCR4 axis and downstream signaling pathways. Yes Overexpressed HOTAIR facilitated proliferation and metastasis in vitro while HOTAIR knockdown inhibit proliferation and metastasis. 31517442 HOTAIR LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Expression[highly expressed] qRT-PCR The expression levels of HOTAIR were significantly upregulated in GC tissues and cell lines. Increased HOTAIR was associated with tumor differentiation, lymph node and distant metastasis, and clinical stage. Furthermore, the area under the ROC curve (AUC) was up to 0.8416 (95 % CI=0.7661 to 0.9170, P<0.0001). The sensitivity and specificity were 66.67 and 87.04%, respectively. The correlation between HOTAIR expression and overall survival (OS) was statistically significant. Yes In addition, knockdown of HOTAIR can inhibit GC cell growth and affect cell cycle distribution. 31281803 HOTAIR LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues regulation[suppressing CCND1 and CCND2,stimulating miRNA-206] Western Blot//ISH//Wound Healing Assay//Flow Cytometry//MTT//Transwell Assay HOTAIR expression significantly increased, and miRNA-206 expression significantly decreased in cancer tissues (p < .01 and p < .001, respectively);HOTAIR knockdown had antitumor effects by suppressing CCND1 and CCND2 expression by stimulating miRNA-206 in gastric cancer in vitro study. Yes HOTAIR knockdown suppressed cell viability, increased cell apoptosis by maintaining cells in the G1 phase, and inhibited cell invasion and migration by regulating miRNA-206 expression (p < .01 or p < .001). 33473276 HOTAIR LncRNA Homo sapiens Stomach Neoplasms GC tissue Expression[highly expressed] CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay Meanwhile, the level of HOTAIR, H19, PVT1, and LINC00152 was upregulated. Yes HOTAIR knockdown GC cells exhibited decreased migration, invasion, proliferation, and upregulated apoptosis, which released more miR-30a and -b into the exosomes. 32951010 HOTAIR LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[miR-1277-5p,COL5A1] qRT-PCR//Western Blot We found that HOTAIR and COL5A1 were overexpressed in GC compared to normal controls, which predicted poor prognosis. HOTAIR regulates GC growth by sponging miR-1277-5p and upregulating COL5A1, and COL5A1-mediated GC cell proliferation may be mediated by effects on the tumor microenvironment, which provides novel targets for GC treatment. Yes HOTAIR/miR-1277-5p/COL5A1 axis in GC was demonstrated, and HOTAIR and COL5A1 were found to promote GC growth while miR-1277-5p exerted the reverse effects. 32583079 HOTAIR LncRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[miR-601/ZEB1 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay HOTAIR was upregulated in BC tissues and cells, and its knockdown suppressed the proliferation, migration, invasion and the activity of AKT signaling pathway of BC cells.In short, this study demonstrated that HOTAIR promoted the proliferation, migration, invasion of BC through regulating the miR-601/ZEB1 axis, which provided a theoretical basis for the research on lncRNA-directed therapeutics in BC. Yes HOTAIR was upregulated in BC tissues and cells, and its knockdown suppressed the proliferation, migration, invasion and the activity of AKT signaling pathway of BC cells. 32694942 HOTAIR LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(miR-129-5p/FZD7 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay HOTAIR and FZD7 were upregulated, while miR-129-5p was down-regulated in breast cancer tissues and cells. FZD7 restored the inhibition of miR-129-5p on breast cancer progression. Furthermore, HOTAIR was a sponge of miR-129-5p and FZD7 was a target of miR-129-5p. Yes Knockdown of miR-129-5p reversed the effect of HOTAIR knockdown on cell proliferation, migration, invasion and EMT. 33104019 HOXA11-AS LncRNA Homo sapiens Skin Neoplasms human skin cancer tissues and cell lines Interaction(PI3K/AKT/mTOR signaling pathway) Flow Cytometry//Transfection//Western Blot//Transwell Assay The results showed significant (P < 0.05) upregulation of lncRNA HOXA11-AS transcript levels in human skin cancer tissues and cell lines. Flow cytometry showed that HOXA11-AS knockdown triggered arrest of the A375 and HMCB cells at G2/M check point of cell cycle by inhibiting the expression of cyclin B1. Additionally, western blot analysis showed that HOXA11-AS knockdown resulted in the deactivation of PI3K/AKT/mTOR signaling pathway. Yes knockdown of HOXA11-AS significantly (P < 0.05) inhibited the proliferation and colony formation of A375 and HMCB skin cancer cells. 33442511 HOXA11-AS LncRNA Homo sapiens Keloid tissues and fibroblasts of keloid Interaction(miR-182-5p on ZNF217) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qPCR//CCK8//Flow Cytometry//RIP//Luciferase Report Assay//Bioinformatics Analysis HOXA11-AS was highly expressed in tissues and fibroblasts of keloid. Deficiency of HOXA11-AS blocked the proliferation and migration of keloid fibroblasts and induced fibroblast apoptosis. HOXA11-AS directly combined to miR-182-5p whose downregulation reversed the effects of HOXA11-AS knockdown. ZNF217 was a target of miR-182-5p, and HOXA11-AS indirectly promoted ZNF217 expression by binding to miR-182-5p. MiR-182-5p enrichment also blocked keloid fibroblast proliferation, survival and migration, while further ZNF217 overexpression abolished these effects. HOXA11-AS knockdown also hindered the growth of keloid in mouse models. Yes Deficiency of HOXA11-AS blocked the proliferation and migration of keloid fibroblasts and induced fibroblast apoptosis. HOXA11-AS directly combined to miR-182-5p whose downregulation reversed the effects of HOXA11-AS knockdown. ZNF217 was a target of miR-182-5p, and HOXA11-AS indirectly promoted ZNF217 expression by binding to miR-182-5p. MiR-182-5p enrichment also blocked keloid fibroblast proliferation, survival and migration, while further ZNF217 overexpression abolished these effects. HOXA11-AS knockdown also hindered the growth of keloid in mouse models. 35987744 HOXA11-AS LncRNA Homo sapiens Keloid keloid tissues and keloid fibroblasts Interaction(miR-205-5p-FOXM1 Pathway) Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Invasion Assay HOXA11-AS and FOXM1 were significantly upregulated in keloid tissues and keloid fibroblasts, while miR-205-5p was downregulated. MiR-205-5p was targeted by HOXA11-AS, and its inhibition overturned the effects of HOXA11-AS knockdown. Moreover, FOXM1 was a target of miR-205-5p, and HOXA11-AS regulated the expression of FOXM1 by adsorbing miR-205-5p. Yes HOXA11-AS knockdown or miR-205-5p enrichment inhibited proliferation, migration, invasion, ECM accumulation, and glycolysis but accelerated apoptosis of keloid fibroblasts. 33261854 HOXB-AS3 LncRNA Homo sapiens Carcinoma, Hepatocellular cancerous tissues Regulation[p53 ] Western Blot//Flow Cytometry//qRT-PCR//RIP//ChIP The results of qRT-PCR showed that the expression of HOXB-AS3 was significantly higher in cancerous tissues of patients with hepatocellular carcinoma than in adjacent tissues.Highly expressed HOXB-AS3 was confirmed to promote the proliferation of hepatocellular carcinoma cells and inhibit apoptosis, and the mechanism was related to the regulation role of HOXB-AS3 in p53 expression by binding to DNMT1. Yes Inhibition of HOXB-AS3 expression in liver cancer cells including Hep3B and LM3 could promote cell proliferation, inhibit cell apoptosis and induce cell cycle arrest in the G0/G1 phase. 30402841 HOXB-AS3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Interaction( IGF2BP2/c-Myc ) qRT-PCR//Colony Formation Assay//Western Blot HOXB-AS3 was upregulated in OSCC tissues, in both TCGA database and in patients with OSCC recruited into the present study.HOXB-AS3 was also found to encode a protein that directly interacted with IGF2BP2 and thereby promoted the stability of c-myc. Taken together, the results from the present study indicated that increased HOXB-AS3 expression was associated with poor prognosis in OSCC. HOXB-AS3 was associated with poor prognosis in OSCC. Yes The proliferation and viability decreased in the 2 OSCC cell lines following knock down of HOXB-AS3. 34457052 HOXB-AS3 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and cells Interaction(miR-498-5p/ADAM9 axis) qRT-PCR//IHC//Western Blot HOXB-AS3 expression was upregulated in EC tissues and cells. A putative miR-498-5p binding site in HOXB-AS3 was verified. Inhibition of miR-498-5p rescued the effects of HOXB-AS3 knockdown on cell proliferation and apoptosis. Finally, ADAM9 was verified as a direct target gene of miR-498-5p. Yes EC cell proliferation and viability decreased significantly in HOXB-AS3 knockdown groups. 34187214 HOXB-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Expression(highly expressed) qRT-PCR In the following study, HOXB-AS1 was unveiled to be highly expressed in HCC tissues as opposed to normal tissues. In summary, this study highlights HOXB-AS1 as key upregulated lncRNA in HCC which being an oncogene can cause proliferation and metastasis of HCC cells. Moreover, the data showed that expression levels of HOXB-AS1 contribute significantly to the patient's survival rates. Yes Silencing of HOXB-AS1 led to the loss of proliferation, migration, and invasiveness of HCC cells, namely Hep3B and Huh7. 36045719 HOXB-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissue regulation[Sponged miR-149-3p to Upregulate Wnt10b] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, We found that HOXB-AS1 expression was significantly upregulated in EC tissue samples and was associated with shorter survival time. In conclusion, our results indicated that HOXB-AS1 exerted oncogenic function as competing endogenous RNA (ceRNA) of miR-149-3p to release Wnt10b and activated Wnt/β-catenin pathway. In this study, We found that HOXB-AS1 expression was significantly upregulated in EC tissue samples and was associated with shorter survival time. Yes Furthermore, upregulation of HOXB-AS1 promoted proliferation, invasion, and migration of EC cell. 33073693 HOXB-AS1 LncRNA Homo sapiens Multiple Myeloma cell lines Regulation[HOXB-AS1/ELAVL1/FUT4 axis] qRT-PCR In this study, we unveiled that HOXB-AS1 was highly expressed in MM and loss-of-function assays certified that HOXB-AS1 obstruction suppressed MM cell proliferation, and stimulated cell apoptosis.In conclusion, the whole modulation mechanism of HOXB-AS1/ELAVL1/FUT4 axis in MM was validated in this study, which suggested that HOXB-AS1 might function as a powerful and promising therapeutic biomarker for the clinical treatment of patients with MM. Yes In this study, we unveiled that HOXB-AS1 was highly expressed in MM and loss-of-function assays certified that HOXB-AS1 obstruction suppressed MM cell proliferation, and stimulated cell apoptosis. 31886581 HOXB13 LncRNA Homo sapiens Glioblastoma GBM tissues Regulation[HOXB13/HOXC-AS3 signaling axis] qRT-PCR Through microarray and immunohistochemistry analyses, HOXB13 was highly expressed in GBM tissues.We believed that HOXB13/HOXC-AS3 signaling axis can be served as therapeutic targets for this highly aggressive cancer. Yes GBM cells U87 and U251 overexpressing HOXB13 showed enhanced proliferation, migration, and invasion relative to the control cells, while knockdown of HOXB13 led to decreased cell proliferation, migration, and invasion abilities. 31062400 HOXA-AS3 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues Interaction(miR-29a-3p/LTβR /NF-κB signaling) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay//IF GC cells and tissues exhibited significant HOXA-AS3 upregulation (P < 0.05), and the levels of this lncRNA were found to be correlated with tumor size, lymph node status, invasion depth, and Helicobacter pylori infection status. At a mechanistic level, we found that HOXA-AS3 was able to sequester miR-29a-3p, thereby regulating the expression of LTβR and modulating NF-κB signaling in GC. GC cells and tissues exhibited significant HOXA-AS3 upregulation (P < 0.05), and the levels of this lncRNA were found to be correlated with tumor size, lymph node status, invasion depth, and Helicobacter pylori infection status. Yes Knocking down HOXA-AS3 disrupted GC cell proliferation, migration, and invasion in vitro and tumor metastasis in vivo. 33602223 HOXA-AS3 LncRNA Homo sapiens Colorectal Neoplasms CRC clinical samples and human CRC cell lines (SW480, SW620, HCT116, COLO205, and LOVO) Interaction(miR-4319/SPNS2 axis) CCK8//qRT-PCR//Western Blot In this study, HOXA-AS3 was significantly over-expressed in CRC clinical samples and human CRC cell lines (SW480, SW620, HCT116, COLO205, and LOVO). The dual luciferase reporter assay suggested that HOXA-AS3 acted as a sponge of miR-4319, and miR-4319 further directly targeted SPNS2 for expression regulation. Besides, HOXA-AS3 was determined to mediate CRC cell proliferation and apoptosis via miR-4319/SPNS2 axis. Yes The depletion of HOXA-AS3 remarkably inhibited cell proliferation, induced cell cycle arrest, and promoted cell apoptosis in CRC cell lines. Additionally, HOXA-AS3 knockdown was determined to facilitate miR-4319 expression and reduce expression level of sphingolipid transporter 2 (SPNS2) in CRC cell lines. 34671931 HOXA-AS3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues and cell lines Regulation[MEK/ERK Signaling Pathway] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In the present study, HOXA-AS3 was highly expressed in HCC tumor tissues and cell lines. Taken together, our study is the first to show the interaction of HOXA-AS3 with miR-29c in facilitating cell proliferation, metastasis, EMT process, and MEK/ERK signaling pathway in HCC. High HOXA-AS3 expression was correlated with low survival of HCC patients. Yes Loss-of-function experiments showed that knockdown of HOXA-AS3 inhibited cell proliferation, migration, invasion, the epithelial-mesenchymal transition (EMT) process, and the mitogen-activated protein kinase/extracellular regulated protein kinase (MEK/ERK) signaling pathway in HCC. 30963785 HOXA-AS3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines Interaction( miR-455-5p/PD-L1 Axis) qRT-PCR High HOXA-AS3 expression was observed in the HCC cell lines. We also identified an miR-455-5p binding site in HOXA-AS3. By sponging miR-455-5p, HOXA-AS3 increased the expression of PD-L1. Additionally, both the inhibition of PD-L1 and overexpression of miR-455-5p reversed the effects on cell proliferation and invasion triggered by the overexpression of HOXA-AS3. Yes Furthermore, overexpression of HOXA-AS3 in HCC cells enhanced proliferation, migration, and invasion, regulated the cell cycle, and retarded apoptosis. 34988230 HOXA-AS3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction(miR-218-5p/COL1A1/LPCAT1 axis) qRT-PCR//Luciferase Report Assay//Colony Formation Assay Here, we found that the expression of lncRNA HOXA-AS3 was upregulated in OSCC tissues and cell lines compared with the para-cancerous tissues and normal human oral keratinocyte (NHOK), respectively. Further, the luciferase reporter assay showed that HOXA-AS3 was directly bound to miR-218-5p. Moreover, the expression of miR-218-5p was negatively regulated by HOXA-AS3, and miR-218-5p could inhibit the expression of collagen type I alpha1 (COL1A1) and lysophosphatidylcholine acyltransferase 1 (LPCAT1). Yes Inhibition of HOXA-AS3 significantly inhibited the proliferation and colony formation of OSCC cells. 34698001 HOXA-AS3 LncRNA Homo sapiens Uterine Cervical Neoplasms tissues and cells Interaction(miR-29a-3p) Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay HOXA-AS3 was elevated and miR-29a-3p was decreased in tissues and cells of cervical cancer patients. Bioinformatics analysis confirmed that HOXA-AS3 negatively regulates cervical cancer development by sponging miR-29a-3p. Knockdown of HOXA-AS3 could inhibit the progression of cervical cancer and was more conducive to patient survival. Yes Knockdown of HOXA-AS3 could inhibit the progression of cervical cancer and was more conducive to patient survival. 35817473 HOXA-AS3 LncRNA Homo sapiens Glioblastoma GBM cells regulation[miR-455-5p/USP3 axis] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Our results showed that lncRNA HOXA-AS3 was significantly up-regulated in GBM cells and could promote GBM cell proliferation, invasion and migration in vitro and in vivo. The newly identified HOXA-AS3/mir-455-5p/USP3 pathway offers important clues to understanding the key mechanisms underlying the action of lncRNA HOXA-AS3 in glioblastoma. HOXA-AS was found to be associated with poor survival prognosis in glioma patients. Yes Our results showed that lncRNA HOXA-AS3 was significantly up-regulated in GBM cells and could promote GBM cell proliferation, invasion and migration in vitro and in vivo. 32918360 HOXA-AS3 LncRNA Homo sapiens Pancreatic Neoplasms PC cells and tissues Interaction(miR-29c/CDK6 axis) qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Western Blot HOXA-AS3 level was upregulated in PC, and its knockdown suppressed PC cells proliferation, whereas miR-29c antagonized the regulatory effect of HOXA-AS3 knockdown by directly binding to HOXA-AS3.Moreover, CDK6 was a target of miR-29c and miR-29c exerted anti-proliferation effects through inhibiting CDK6. Yes HOXA-AS3 level was upregulated in PC, and its knockdown suppressed PC cells proliferation, whereas miR-29c antagonized the regulatory effect of HOXA-AS3 knockdown by directly binding to HOXA-AS3. 34659534 HOXA-AS2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue Interaction[microRNA-216a-5p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay In this experiment, qRT-PCR results revealed that HOXA-AS2 level in NSCLC tumor tissue specimens was remarkably higher than that in adjacent tissues. Subsequently, qRT-PCR verified that microRNA-216a-5p level was remarkably decreased in NSCLC tissues and negatively correlated with HOXA-AS2 expression. In addition, the result of the cell recovery experiment and Western blotting revealed that there might be a mutual regulation between HOXA-AS2 and microRNA-216a-5p, the two of which could jointly regulate the malignant progression of NSCLC. Compared with those with low expression of HOXA-AS2, the patients with high expression had a higher incidence of distant metastases and a lower overall survival rate. Yes The proliferative and metastasis abilities of the cells in the HOXA-AS2 overexpression group were remarkably increased when compared with the control group, while the opposite results were observed in HOXA-AS2 silence group. 31389597 HOXA-AS2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[upregulating IGF2] qRT-PCR//Wound Healing Assay//Transwell Assay By comparing with the expression level in adjacent tissues, HOXA-AS2 expression was higher in NSCLC samples. In this work, HOXA-AS2 could enhance migratory and invasive abilities of NSCLC cells by upregulating IGF2, which might offer a potential therapeutic target for NSCLC. Yes Moreover, HOXA-AS2 knockdown inhibited invasion and migration of NSCLC cells and, conversely, HOXA-AS2 overexpression obtained the opposite results. 31210310 HOXA-AS2 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues,cell lines Regulation[miR-125b/Smad2 axis ] Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Invasion Assay Our results firstly demonstrated the upregulation of HOXA-AS2 in both bladder cancer cells and clinical bladder tumors.Furthermore, this study also identified miR-125b as a downstream target of HOXA-AS2 and revealed the downregulation of miR-125b by HOXA-AS2 as well as the involvement of HOXA-AS2/miR-125b/Smad2 interactions in the functional role of HOXA-AS2 in mediating the migration, invasion and stemness of bladder cancer cells. Such upregulation was also positively correlated with the advanced stage, invasion and lymph node metastasis of bladder cancer as well as the expression of cancer stem cell marker OCT4 in patients. Yes Such upregulation was also positively correlated with the advanced stage, invasion and lymph node metastasis of bladder cancer as well as the expression of cancer stem cell marker OCT4 in patients. 30412716 HOXA-AS2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells and tissues Interaction(miR-567/CDK8) qRT-PCR//Western Blot LncRNA HOXA-AS2 was up-regulated in OSCC cells and tissues with the expression of miR-567 decreased. In terms of the mechanism, we found that lncRNA HOXA-AS2 negatively regulates miR-567 expression via a direct interaction. We also observed that miR-567 directly targets the 3' UTR of CDK8. Moreover, silencing lncRNA HOXA-AS2 inhibited tumor growth with the expression of miR-567 increased and CDK8 decreased in vivo. The tissue lncRNA HOXA-AS2 expression was found to positively correlate with the TNM stage and lymph node metastasis of OSCC patients. Yes Functionally, overexpression of lncRNA HOXA-AS2 significantly promoted OSCC cell proliferation, while knockdown of lncRNA HOXA-AS2 significantly inhibited it. 34267554 HOXA-AS2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells Interaction(EZH2) Western Blot//CCK8//qRT-PCR//Cell Cycle Assay//EdU Staining Compared with HIOEC cells, HOXA-AS2 expression in OSCC cells was upregulated. In addition, HOXA-AS2 was predicted to directly target EZH2 and positively regulate EZH2 expression. EZH2 overexpression could reverse the inhibitory effect of HOXA-AS2 knockdown on the proliferation, migration, and invasion of Tca-8113 cells. Yes HOXA-AS2 knockdown significantly inhibited Tca-8113 cell proliferation, blocked the cell cycle by arresting cells in the G0/G1 phase, promoted apoptosis, and suppressed migration and invasion. 34519570 HOXB-AS3 LncRNA Homo sapiens Ovarian Neoplasms EOC tissues Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay HOXB-AS3 was abundantly expressed in EOC tissues, and higher levels of HOXB-AS3 in EOC patients were significantly associated with disease status and overall survival status. HOXB-AS3 was abundantly expressed in EOC tissues, and higher levels of HOXB-AS3 in EOC patients were significantly associated with disease status and overall survival status. EOC patients with high levels of HOXB-AS3 had strikingly shorter disease-free survival (DFS) and overall survival (OS) times than those with low levels. HOXB-AS3 also might as an independent prognostic factor. Yes Further study revealed knockdown of HOXB-AS3 significantly inhibited the proliferation, invasion and migration of EOC cells. 33148416 HOXB-AS3 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC patients Interaction(miR-378a-3p/LDHA/ECAR) qRT-PCR//Western Blot HOXB-AS3 was abundantly expressed in EOC tissues, and higher levels of HOXB-AS3 in EOC patients were significantly associated with disease status and overall survival status.Mechanistic investigations suggested that knockdown of HOXB-AS3 could decrease lactate dehydrogenase A (LDHA) expression and the extracellular acidification rate (ECAR) by sponging miR-378a-3p. HOXB-AS3 was abundantly expressed in EOC tissues, and higher levels of HOXB-AS3 in EOC patients were significantly associated with disease status and overall survival status. EOC patients with high levels of HOXB-AS3 had strikingly shorter disease-free survival (DFS) and overall survival (OS) times than those with low levels. Yes Further study revealed knockdown of HOXB-AS3 significantly inhibited the proliferation, invasion and migration of EOC cells. 33148416 HOXB-AS3 LncRNA Homo sapiens Lung Neoplasms NSCLC tissues and cells regulation[ PI3K-AKT pathway] qRT-PCR In the current research, we found HOXB-AS3 was obviously elevated in NSCLC tissues and cells. Overall, we implied that HOXB-AS3 might provide a new perspective for lung cancer treatment via targeting PI3K/AKT. Yes Functional assays showed that inhibition of HOXB-AS3 was able to repress A549 and H1975 cell proliferation, cell colony formation ability and meanwhile, triggered cell apoptosis. 32039488 HOXD-AS2 LncRNA Homo sapiens Glioma cell lines Expression[highly expressed] qRT-PCR HOXD-AS2 was increased in glioma cells and it was associated with glioma grade and poor prognosis. HOXD-AS2 was increased in glioma cells and it was associated with glioma grade and poor prognosis. Yes Loss of HOXD-AS2 can inhibit glioma cell growth by inducing cell-cycle G1 arrest in vitro. 30485495 HOXD-AS2 LncRNA Homo sapiens Glioma glioma tissues and cells Expression(highly expressed) cell invasion assay//Migration Assay//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay The expression level of HOXD-AS2 gene in glioma was significantly higher than that in the normal brain tissue, which was related to the tumor grade. The level of HOXD-AS2 gene in patients with high-grade glioma was higher than that in patients with low-grade glioma. High expression of HOXD-AS2 gene was a risk factor for poor prognosis of glioma patients. Yes Knocking down the expression of HOXD-AS2 in glioma cell line U251 arrested the cell cycle and reduced the cell proliferation. Furthermore, it could significantly reduce the migration ability of the cells but had no significant effect on the invasion. 36408341 HOXD-AS2 LncRNA Homo sapiens Glioblastoma GBM patient tumor samples and GBM cell lines Interaction(miR-3681-5p/MALT1 signaling pathway) In Vivo Experiment//cell invasion assay//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//IHC HOXD-AS2 was found to be significantly up-regulated in GBM tissues, which was further confirmed in GBM patient tumor samples and GBM cell lines. We further identified and validated miR-3681-5p as a target of HOXD-AS2, and miR-3681-5p was negatively regulated by HOXD-AS2. By negatively affecting miR-3681-5p, HOXD-AS2 could promote the expression of MALT1 to augment the aggressiveness of GBM cells. miR-3681-5p overexpression or MALT1 knockdown attenuated aggressiveness of GBM cells. Yes Silencing HOXD-AS2 inhibited cell proliferation, migration and invasion, and promoted cell apoptosis. 34802389 HOXC-AS3 LncRNA Homo sapiens Breast Neoplasms Interaction[sponging miR-3922-5p] Wound Healing Assay//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay HOXC-AS3 is aberrantly overexpressed in breast cancers especially the HER2 type.Our results demonstrated that miR-3922-5p was a direct target of HOXC-AS3, and PPP1R1A was a target of miR-3922-5p in breast cancer Yes In addition, HOXC-AS3 regulates cell Invasion and migration both in vitro and in vivo. 31797701 HOXC-AS3 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues interaction[binding to YBX1] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//ChIP Based on public breast cancer expression data and using bioinformatics methods, we discovered significantly upregulated expression levels of HOXC-AS3 in diseased tissues.Further, mechanistic studies demonstrated the potential of HOXC-AS3 in the transcriptional activation of TK1 via its binding to YBX1. Furthermore, the silencing of TK1 reversed HOXC-AS3-mediated increase in breast cancer cell growth and migration. We verified this result in breast cancer samples and found that the expression of HOXC-AS3 was well correlated with the prognosis of breast cancer. Yes In vitro and in vivo experimental evidence suggests that HOXC-AS3 has the potential to regulate tumorigenesis. 33194034 HOXC-AS3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-96) qRT-PCR//RNA Pull-Down//Transwell Assay NSCLC tissues exhibited significantly increased expression levels of HOXC-AS3 and premature miR-96. HOXC-AS3 was localized to both nucleus and cytoplasm, and a direct interaction between HOXC-AS3 and premature miR-96 was observed. In NSCLC cells, HOXC-AS3 upregulated the expression of premature miR-96 but downregulated the expression of mature miR-96. Yes HOXC-AS3 suppressed the role of miR-96 in inhibiting NSCLC cell invasion and migration. 35034519 HOXC-AS3 LncRNA Homo sapiens Ovarian Neoplasms OC tissues Interaction(miR-96) CCK8//qRT-PCR//Western Blot HOXC-AS3 was upregulated in OC, while mature miR-96 and miR-96 precursor were downregulated in OC. In OC cells, overexpression of HOXC-AS3 reduced the expression levels of mature miR-96, but not miR-96 precursor. In addition, overexpression of HOXC-AS3 attenuated the effects of overexpression of miR-96. HOXC-AS3 suppresses the formation of mature miR-96 in OC cells to promote cell proliferation. Yes Cell proliferation analysis showed that overexpression of HOXC-AS3 resulted in increased cell proliferation, while overexpression of miR-96 suppressed cell proliferation. 33651311 HOXC-AS3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC specimens and cells Interaction(HOXC-AS3/YBX1/HOXC8 axis ) In Vivo Experiment//Wound Healing Assay//CCK8//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The levels of HOXC-AS3 and HOXC8 were increased in human NSCLC specimens and cells. HOXC-AS3 directly bound to YBX1 to suppress its ubiquitination mediated by MDM2. YBX1 bound to the HOXC8 promoter and enhanced its transcription. Knockdown of HOXC8 inhibited the effects of HOXC-AS3 overexpression on NSCLC. HOXC-AS3 promotes NSCLC growth and metastasis by stabilising YBX1 and thus increasing HOXC8 transcription. Yes Knockdown of HOXC-AS3 suppressed NSCLC cell proliferation, migration and invasion, as well as tumour growth and metastasis in vivo. 35387975 HOXC-AS2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(HOXC13 ) qRT-PCR//IHC//RIP//Transwell Assay We found that HOXC-AS2 was significantly up-regulated in NSCLC tissues. Taken together, HOXC-AS2 knockdown inhibited NSCLC cell proliferation and migration, as well as stimulated NSCLC cell apoptosis through regulation of HOXC13 expression. Yes HOXC-AS2 expression resulted in significant decreases in NSCLC cell proliferation, migration, and epithelial-mesenchymal transition (EMT) process marker proteins, simultaneously activated A549 and HCC827 cell apoptosis. 33427025 HOXC-AS2 LncRNA Homo sapiens Glioma glioma cells and tissues Interaction[HOXC-AS2/miR-876-5p/ZEB1] qRT-PCR//Luciferase Report Assay//RIP We found HOXC-AS2 was upregulated in glioma cells and tissues. Our results conclude that HOXC-AS2/miR-876-5p/ZEB1 constitutes a positive feedback loop to regulate EMT in GBM, providing a potential therapeutic target for glioma. Yes Depletion of HOXC-AS2 was associated with the inhibition of migration, invasion and EMT process in glioma cells. 31571911 HOXC-AS1 LncRNA Homo sapiens Stomach Neoplasms GC cells regulation[Wnt/β-catenin signaling] CCK8//qRT-PCR//Flow Cytometry//Western Blot lncRNA HOXC-AS1 expression is up-regulated in GC cells and a decrease of lncRNA HOXC-AS1 inhibited cell viability. HOXC-AS1 may promote the proliferation and the EMT process and inhibit apoptosis by binding eIF4AIII via Wnt/β-catenin signaling, which indicates that HOXC-AS1/eIF4AIII might be an axis that could be further used as a biomarker to help with the diagnosis of GC. Yes lncRNA HOXC-AS1 expression is up-regulated in GC cells and a decrease of lncRNA HOXC-AS1 inhibited cell viability. 32307743 HOXC-AS1 LncRNA Homo sapiens Stomach Neoplasms GC cells Interaction(miR-99a-3p/MMP8) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Therefore, we examined GC cells and tissues for the expression of HOXC-AS1 and correlated the expression levels with the disease specific survival of the patients, finding that HOXC-AS1 was overexpressed and probably had a tendency of leading to a poor prognosis. After knockdown of HOXC-AS1, miR-99a-3p was clearly overexpressed in GC cells. In addition, matrix metalloproteinase 8 (MMP8) was shown to be combined with miR-99a-3p using TargetScan. Similar experiments, along with western blot, were conducted to validate the correlation between miR-99a-3p and MMP8. Finally, rescue experiments for CCK-8 were completed, disclosing that HOXC-AS1 promoted cell progression of GC through sponging miR-99a-3p followed by subsequent upregulation of MMP8. Therefore, we examined GC cells and tissues for the expression of HOXC-AS1 and correlated the expression levels with the disease specific survival of the patients, finding that HOXC-AS1 was overexpressed and probably had a tendency of leading to a poor prognosis. Yes The Cell Counting Kit-8 assay and colony formation assay were then performed under knockdown of HOXC-AS1, revealing that cell proliferation of GC was distinctly decreased. Afterwards, miR-99a-3p was predicted to bind with HOXC-AS1 by DIANA tools. 35884594 HOXC-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cells Interaction(IGF2BP2 ) RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//RIP//Colony Formation Assay//EdU Staining//Transwell Assay HOXC-AS1 is highly expressed in ESCC cells and plays oncogenic effects in vivo. qPCR showed the positive relationship between HOXC-AS1 and SIRT1 following HOXC-AS1 knockdown or overexpression. RNA-pulldown, mass spectrometry and RIP assay demonstrated that IGF2BP2 is an RBP downstream of HOXC-AS1. Then, RIP and qPCR showed that IGF2BP2 could bind to SIRT1 mRNA and knockdown IGF2BP2 resulted in decreased SIRT1 mRNA level. Finally, a series of rescue assay showed that the HOXC-AS1-IGF2BP2-SIRT1 axis can affect the function of ESCC. Yes HOXC-AS1 is highly expressed in ESCC cells and plays oncogenic effects in vivo. qPCR showed the positive relationship between HOXC-AS1 and SIRT1 following HOXC-AS1 knockdown or overexpression. 36510377 HOXC-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC and in NPC cell lines Interaction(miR-4651/FOXO6 ) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The present study found that HOXC-AS1 was highly expressed in NPC and in NPC cell lines, suggesting a critical role of HOXC-AS1 in NPC progression. We found that HOXC-AS1 could sponge miR-4651 subsequently binding FOXO6 and inhibiting its expression. Therefore, HOXC-AS1/miR-4651/FOXO6 may form a competing endogenous RNA (ceRNA) network that promotes NPC progression. In addition, the abundance of HOXC-AS1 was negatively correlated with the prognosis of NPC. Yes It could be observed that HOXC-AS1 knockdown decreases cell proliferation, migration and invasion, but induces cell apoptosis in NPC. 34507637 HOXC9 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung LUAD tumor tissues and cell lines Interaction(circCENPF/hsa-miR-184 axis ) cell invasion assay//Migration Assay//Proliferation Assay//migration assay//PCR//Cell Proliferation Assay//Invasion Assay//IF HOXC9 expression was increased in NSCLC and correlated with poor prognosis in lung adenocarcinoma. In addition, HOXC9 expression levels were significantly correlated with immune cell infiltration of tumors and biomarkers of immune cells. Finally, the circCENPF/hsa-miR-184 axis was identified as the most promising upstream regulatory pathway of HOXC9 in lung adenocarcinoma. HOXC9 expression was increased in NSCLC and correlated with poor prognosis in lung adenocarcinoma. Yes Overexpression of HOXC9 promoted NSCLC cell proliferation, migration, and invasion in vitro. 36272177 HOXC13-AS-201 LncRNA Homo sapiens Ameloblastoma AB tissues Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Real-time qPCR confirmed that lncRNA ENST00000512916 was up-regulated in AB tissues. Yes ENST00000512916 knockdown significantly inhibited cell proliferation, migration and the expression of CDK2/4/6 in AM-1 cells. Moreover, ENST00000512916 knockdown suppressed tumor growth in vivo. 32110049 HOXC13-AS LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[miR-497-5p/PTEN axis] CCK8//qRT-PCR//Colony Formation Assay It showed that HOXC13-AS was increased in breast cancer tissues compared with the adjacent normal tissues and upregulated HOXC13-AS promoted the growth of breast cancer cells. Hence, we conclude that HOXC13-AS, which is significantly upregulated in breast cancers, promoted cell proliferation through the suppressed miR-497-5p and further upregulated PTEN. Yes It showed that HOXC13-AS was increased in breast cancer tissues compared with the adjacent normal tissues and upregulated HOXC13-AS promoted the growth of breast cancer cells. 31066051 HOXC13-AS LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines regulation[ miR-378g/HOXC13 axis] Western Blot//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//EdU Staining//Transwell Assay In this study, GEPIA indicated that HOXC13-AS and its neighbor gene HOXC13 were upregulated in HNSC samples, and we consistently unveiled their upregulation in OSCC tissues and cell lines. In sum, our findings suggested that HOXC13-AS functioned as a ceRNA to accelerate the malignant behaviors of OSCC cells via miR-378g/HOXC13 axis, shedding a new light on the lncRNA-targeted treatment for OSCC. Yes Silencing HOXC13-AS abrogated OSCC cell proliferation, migration, and epithelial-to-mesenchymal transition (EMT). 32763778 HOXBLINC LncRNA Mus musculus Leukemia, Myeloid, Acute HSPCs Regulation In Vivo Experiment//colony Formation Assay//Flow Cytometry//qRT-PCR//RIP//RNA-seq//ChIP-seq//ChIP Here, we show that the activation of HOXBLINC, a HOXB locus-associated long non-coding RNA (lncRNA), is a critical downstream mediator of NPM1c+-associated leukemic transcription program and leukemogenesis. Mechanistically, HoxBlinc binds to the promoter regions of NPM1c+ signature genes to control their activation in HoxBlincTg HSPCs, via MLL1 recruitment and promoter H3K4me3 modification. Yes HOXBLINC loss attenuates NPM1c+-driven leukemogenesis by rectifying the signature of NPM1c+ leukemic transcription programs. Furthermore, overexpression of HoxBlinc (HoxBlincTg) in mice enhances HSC self-renewal and expands myelopoiesis, leading to the development of AML-like disease, reminiscent of the phenotypes seen in the Npm1 mutant knock-in (Npm1c/+) mice. HoxBlincTg and Npm1c/+ HSPCs share significantly overlapped transcriptome and chromatin structure. 33782403 HOXA-AS2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction(miR-520c-3p/SNX5 axis) Western Blot//Tunel//CCK8//qRT-PCR//Transwell Assay We found that HOXA-AS2 expression was remarkably upregulated in OSCC tissues and cell lines. Our bioinformatics analysis found that HOXA-AS2 can target miR-520c-3p, which was confirmed by dual-luciferase reporter gene assay. The expression of HOXA-AS2 was found to be negatively associated with miR-520c-3p in OSCC tissues. Moreover, sorting nexin 5 (SNX5), a downstream target of miR-520c-3p, was inhibited by miR-520c-3p overexpression. SNX5 was also increased in OSCC tissues and cell lines. Additionally, we found that the higher expression of SNX5 was strongly associated with the tumor grade of OSCC patients in Oncomine database. Yes The downregulation of HOXA-AS2 inhibited cells proliferation, migration and invasion. Most importantly, the knockdown of HOXA-AS2 induced cells apoptosis by promoting autophagy by regulating SNX5. 36528556 HOXA-AS2 LncRNA Homo sapiens Osteosarcoma OS tissues interaction[miR-520c-3p ] qRT-PCR//Luciferase Report Assay We observed that HOXA-AS2 was up-regulated in OS tissues.HOXA-AS2 could negatively regulate the expression of miR-520c-3p in OS cells. Yes In vitro experiments revealed that HOXA-AS2 knockdown significantly inhibited OS cells proliferation by promoting apoptosis and causing G1 arrest, whereas HOXA-AS2 overexpression promoted cell proliferation. 30081707 HOXA-AS2 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction[miR-124-3p/E2F3] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay HOXA-AS2 expression was increased in OS tissues and cells and associated with poor survival of patients. HOXA-AS2 silence impeded OS progression possibly by functioning as a decoy of miR-124-3p to target E2F3, indicating novel evidence of HOXA-AS2 as a promising therapeutic target of OS. HOXA-AS2 expression was increased in OS tissues and cells and associated with poor survival of patients. Yes Knockdown of HOXA-AS2 inhibited cell viability, migration and invasion in OS cells. 31853184 HOXA-AS2 LncRNA Homo sapiens Parkinson Disease PBMCs of PD patients Interaction(PRC2/PGC-1α) qRT-PCR//RNA Pull-Down We found that HOXA-AS2 was upregulated in the PBMCs of PD patients and negatively associated with peroxisome proliferator-activated receptor gamma coactivator-1a (PGC-1α) expression.Mechanistic investigations demonstrated that HOXA-AS2 could directly interact with polycomb repressive complex 2 (PRC2) and modulate the histone methylation of the promoter of PGC-1α. Yes Moreover, HOXA-AS2 knockdown significantly repressed microglial M1 polarization and promoted M2 polarization by regulating PGC-1α expression. 34511122 HOXA11-AS LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-506-3p/Slug axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay RT?qPCR revealed that HOXA11?AS expression was increased, while that of miR?506?3p was decreased in HCC tissues and cells compared with that in adjacent non?tumor tissues and normal hepatic cells. Taken together, the present study demonstrates that HOXA11‑AS functions as an oncogene to promote the progression of HCC via the miR‑506‑3p/Slug axis, providing a therapeutic target for patients with HCC. Yes miR?506?3p downregulation reversed the inhibitory effects of HOXA11?AS deletion on cell proliferation, invasion and epithelial?mesenchymal transition (EMT), as shown by CCK?8 and Transwell assays, as well as western blot analysis. 32901858 HOXA11-AS LncRNA Homo sapiens Ovarian Neoplasms Ovarian cancer cells Expression(highly expressed) Western Blot//CCK8//qRT-PCR//Cell Cycle Assay//Transwell Assay Ovarian cancer cells expressed HOXA11-AS substantially higher than normal cells, while cisplatin-resistant cells expressed HOXA11-AS significantly higher than ovarian cancer cells. Yes HOXA11-AS knockdown was found to significantly inhibit cell viability, migration, and invasion of A2780 and OVCAR3 cells, and promote apoptosis by CCK-8 assay, transwell assay, cell cycle, and apoptosis assay, and promoted the sensitivity of A2780/DDP cells to cisplatin. It has been shown by the western blot test that HOXA11-AS knockdown increases the amount of cellular autophagy in cells.In contrast, adding the autophagy inhibitor 3-methyladenine (3-MA) to HOXA11-AS cells knocked down in vivo reduced its anti-tumor properties. 35706412 HOXA11-AS LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Regulation[HOXA11-AS/miR-98-5p/YBX2 axis] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay HOXA11-AS was highly expressed in OSCC tissues and cells.HOXA11-AS plays an active role in the progression of OSCC, and the discovery of HOXA11-AS/miR-98-5p/YBX2 axis provides new therapeutic targets for OSCC. Yes Knockdown of HOXA11-AS significantly reduced proliferation, migration, invasion and EMT, while promoted apoptosis of OSCC cells. 31731187 HOXA11-AS LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Regulation[miR-518a-3p/PDK1 axis] qRT-PCR qRT-PCR analysis indicated that HOXA11-AS expression was significantly upregulated in OSCC tissues.Taken together, our study demonstrates that HOXA11-AS/miR-518a-3p/PDK1 axis is an important regulator of OSCC progression and may serve as a potential therapeutic target in OSCC. Yes Functional studies revealed that HOXA11-AS significantly promotes cell proliferation, reduces the percentage of G0/G1 phase cells and enhances the cell invasion in OSCC. In a mouse model of OSCC, HOXA11-AS overexpression promoted tumor growth, concomitant with reduced miR-518a-3p expression and increased PDK1 expression. 31139017 HOXA11-AS LncRNA Homo sapiens Osteosarcoma OS tissues and OS cell lines Interaction[ sponging miR-125a-5p] qRT-PCR It was found that HOXA11-AS expression levels in OS tissues and OS cell lines were higher than those in OS adjacent tissues and normal human osteoblast cell lines. Our study elucidated the role of a new HOXA11-AS/miR-125a-5p/Rab3D regulatory pathway in promoting OS metastasis. The higher expression level of HOXA11-AS was positively correlated with more severe clinical stage, distant metastasis and poor prognosis of OS. Yes Inhibition of HOXA11-AS expression could reduce metastasis and invasion of OS cell lines. 31191012 HOXA11-AS LncRNA Homo sapiens Glioma glioma tissues interaction[miR-124-3p] qRT-PCR We found that LncRNA HOXA11-AS expression was markedly elevated in glioma tissues compared to normal brain tissues.In summary, the findings highlight the importance of LncRNA HOXA11-AS/miR-124-3p axis in the regulation of glioma progression. The LncRNA HOXA11-AS expression in cases of high-grade glioma was significantly higher than that in cases of low-grade. Patients with high LncRNA HOXA11-AS expression had shorter OS time than those with low LncRNA HOXA11-AS expression. Yes Moreover, silencing LncRNA HOXA11-AS inhibited cell proliferation, increased apoptosis, and inhibited invasion and migration of glioma cells. 30064227 HOXA11-AS LncRNA Homo sapiens Glioma glioma tissues Interaction[upregulating microRNA-125a] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Results indicated that lncRNA HOXA11-AS was significantly increased in U251 cells and positively correlated with glioma World Health Organization (WHO) grade in glioma tissues. miR-125a inhibitor could partially reverse these effects of lncRNA HOXA11-AS silencing on U251 cells. In vivo assays also indicated that lncRNA HOXA11-AS inhibitor could inhibit glioma growth in vivo by regulating the expression of miR-125a. In conclusion, we revealed that lncRNA HOXA11-AS acted as an oncogene in glioma via interacting with miR-125a and considered that lncRNA HOXA11-AS was a potential therapeutic target for glioma. Results indicated that lncRNA HOXA11-AS was significantly increased in U251 cells and positively correlated with glioma World Health Organization (WHO) grade in glioma tissues. Yes lncRNA HOXA11-AS silencing could inhibit cell migration, invasion, proliferation, and promote apoptosis, while up-regulate the expression of caspase-3/8/9 and Bax, inhibit the expression of Bcl-2 and gab2 in U251 cells. 31737190 HOXA11-AS LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction[miR-130a-5p/HMGB2] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the current study, we demonstrated that the lncRNA HOXA11-AS was overexpressed in glioma. Finally, we revealed that HOXA11-AS exerted its oncogenic effects by binding to miR-130a-5p, thereby neutralizing the suppressive effect of miR-130a-5p on HMGB2. The overexpression of HOXA11-AS was correlated with advanced stages of glioma and poor prognosis. Yes Downregulating HOXA11-AS expression significantly suppressed the proliferation, migration and invasion of glioma cells and increased their apoptosis. The growth of glioma cells in vitro was also suppressed by the downregulation of HOXA11-AS. 30657566 HOXA11-AS LncRNA Homo sapiens Glioma glioma tissues Interaction(miR-124 Axis) In Vivo Experiment//qRT-PCR//Cell Proliferation Assay//Luciferase Report Assay//Cell Apoptosis Assay//cell invasion assay Here, HOXA11-AS was overexpressed and miR-124 was underexpressed in glioma. Expression of miR-124 was negatively related to that of HOXA11-AS. Expression of miR-124 was repressed by HOXA11-AS functioning as sponge. In addition, miR-124 knockdown partially abolished the inhibitory roles of HOXA11-AS downregulation in glioma cells. Yes Silencing of HOXA11-AS suppressed cell proliferation, invasion, and promoted apoptosis in glioma cells in vitro. Moreover, inhibition of HOXA11-AS expression repressed glioma xenograft tumor growth. 34117619 HOXA11-AS LncRNA Homo sapiens Glioma glioma tissues and cells Interaction(Tpl2-MEK1/2-ERK1/2 pathway) In Vivo Experiment//Wound Healing Assay//CCK8//qRT-PCR//IF//H&E Staining//IHC//EdU Staining//Transwell Assay We found that HOXA11-AS was significantly upregulated in glioma, and was correlated with the poor prognosis of glioma patients. Mechanistically, HOXA11-AS acted as a molecular sponge for let-7b-5p in the cytoplasm, antagonizing its ability to repress the expression of CTHRC1, which activates the β-catenin/c-Myc pathway. In addition, c-Myc was involved in HOXA11-AS dysregulation via binding to its promoter region to form a self-activating loop. We found that HOXA11-AS was significantly upregulated in glioma, and was correlated with the poor prognosis of glioma patients. Yes Ectopic expression of HOXA11-AS promoted the proliferation, migration, and invasion of glioma cells in vitro and in vivo. 36351895 HOXA11-AS LncRNA Homo sapiens Adenocarcinoma of Lung LUAD Interaction(microRNA-148b-3p/PKM2 axis) Luciferase Report Assay//Bioinformatics Analysis The expression of HOXA11-AS was markedly increased in LUAD, and was strongly associated with a poor prognosis. In addition, HOXA11-AS promoted proliferation and glycolysis in LUAD, and miR-148b-3p inhibited proliferation and glycolysis in LUAD. Mechanistically, HOXA11-AS positively regulated PKM2 expression by binding to miR-148b-3p, thereby promoting LUAD proliferation and glycolysis. In addition, HOXA11-AS inhibited LUAD xenograft growth and glycolysis via upregulation of miR-148b-3p expression and downregulation of PKM2 expression in vivo. The expression of HOXA11-AS was markedly increased in LUAD, and was strongly associated with a poor prognosis. Yes Mechanistically, HOXA11-AS positively regulated PKM2 expression by binding to miR-148b-3p, thereby promoting LUAD proliferation and glycolysis. 35924724 HOXA11-AS LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cancer tissues and cell lines Interaction(Let-7c-5p/IGF2BP1 Axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis Upregulation of lncRNA HOXA11-AS was found in LUAD, and suppression of HOXA11-AS could suppress the proliferative ability of LUAD cells. The let-7c-5p was expressed to be downregulated, which played an inhibitory role in LUAD cell proliferation. Let-7c-5p was negatively regulated by HOXA11-AS. HOXA11-AS promoted LUAD cell proliferation by targeting let-7c-5p/IGF2BP1, which could be potential molecular targets for LUAD. Yes HOXA11-AS promoted LUAD cell proliferation, while let-7c-5p had an inverse effect. Besides, IGF2BP1, regulated by let-7c-5p, had a positive relation with HOXA11-AS, while overexpression of IGF2BP1 could suppress the inhibition of silencing HOXA11-AS on LUAD cell proliferation. Experiments on mice confirmed that HOXA11-AS facilitated LUAD cell growth in vivo through regulating the let-7c-5p/IGF2BP1 axis 35368660 HOXA11-AS LncRNA Homo sapiens Prostatic Neoplasms regulation[miR-518b/ACTN4 axis ] Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay HOXA11-AS in PCa cells was expressed at high levels.CTCF-induced upregulation of HOXA11-AS facilitates PCa progression via miR-518b/ACTN4 axis, providing a new target for PCa treatment. Yes Silenced HOXA11-AS in PCa cells could lead to a significant elevation in the abilities of cell proliferation and migration whereas a remarkable declination in cell apoptosis capability. 31971633 HOXA11-AS LncRNA Homo sapiens Prostatic Neoplasms cell lines Expression(highly expressed) qPCR//Luciferase Report Assay//Microarray In this study, we found that homeobox A11 antisense RNA (HOXA11-AS), a highly expressed lncRNA in cell lines derived from prostate cancer bone metastases, promoted the cell invasion and proliferation of PC3 prostate cancer cells. These results suggest that prostate cancer HOXA11-AS and HOXB13 promote metastasis by regulation of CCL2/CCR2 cytokine and integrin signaling in autocrine and paracrine manners. Yes In this study, we found that homeobox A11 antisense RNA (HOXA11-AS), a highly expressed lncRNA in cell lines derived from prostate cancer bone metastases, promoted the cell invasion and proliferation of PC3 prostate cancer cells. 33514011 HOXA11-AS LncRNA Homo sapiens Prostatic Neoplasms Pca tissues Interaction(miR-24-3p/JPT1 axis) In Vivo Experiment//RNA Pull-Down//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay We revealed that HOXA11-AS was upregulated in PCa. Furthermore, we showed that HOXA11-AS1 serves as a competing endogenous RNA (ceRNA) to regulate Jupiter microtubule associated homolog 1 (JPT1) via sponging microRNA-24-3p (miR-24-3p). Functionally, the overexpression of miR-24-3p or knockdown of JPT1 could partially reverse the effects of HOXA11-AS overexpression on PCa cell behaviors. Yes Silencing of HOXA11-AS significantly inhibited PCa cell proliferation, colony formation, invasion, and promoted apoptosis in vitro. On the contrary, forcing of HOXA11-AS expression caused opposite effects on cancer cell behaviors. 34337714 HOXA11-AS LncRNA Homo sapiens skin melanoma melanoma tissues Interaction(miR-152-3p/ITGA9 Axis) In Vivo Experiment//Western Blot//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay HOXA11-AS and ITGA9 were up-regulated while miR-152-3p was down-regulated in melanoma. HOXA11-AS modulated proliferation, apoptosis, metastasis and EMT in melanoma cells by regulating miR-152-3p/ITGA9 axis in part. Yes Knockdown of HOXA11-AS refrained cell proliferation, metastasis and epithelial-mesenchymal transition (EMT) but induced apoptosis in melanoma cells. 33564267 HOXA11-AS LncRNA Homo sapiens Demyelinating Diseases keloid tissues Regulation[ miR-124-3p/TGFβR1 axis] Flow Cytometry//qRT-PCR//Tunel//Western Blot We found that HOXA11-AS and TGFβR1 were significantly up-regulated, while miR-124-3p was down-regulated both in keloid tissues or fibroblasts than in normal skin tissues or fibroblasts. Taken together, our findings revealed that HOXA11-AS inhibits cell apoptosis and promotes angiogenesis through miR-124-3p/TGFβR1 axis, contributing to the progression of keloid formation, which might provide a novel target for keloid therapy. Yes Functionally, high expression of HOXA11-AS essentially inhibited cell apoptosis and promoted fibroblast-induced angiogenesis. 31878829 HOXA11-AS LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HSCC tumors interaction[Sponging miR-155] Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay The current study demonstrated that the expression of HOXA11-AS was significantly upregulated in HSCC tumors and was positively associated with lymph node metastasis.Furthermore, luciferase reporter gene assay combined with cellular functional experiments demonstrated that HOXA11-AS functioned as a molecular sponge for miR-155, and inhibition of miR-155 attenuated the suppressive effect of HOXA11-AS knockdown on the aggressive phenotype in HSCC. The current study demonstrated that the expression of HOXA11-AS was significantly upregulated in HSCC tumors and was positively associated with lymph node metastasis. Yes Moreover, functional experiments revealed that HOXA11-AS knockdown suppressed the proliferation and migration potential in FaDu cells. 31987067 HOXA11-AS LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cells Interaction(miR-155/C-Myc) In Vivo Experiment//Wound Healing Assay//Transfection//qRT-PCR//MTT//RNA-seq//Cell Apoptosis Assay//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//EdU Staining//Transwell Assay High-throughput sequencing data revealed that lncRNA HOXA11-AS was significantly downregulated in cells co-incubated with SM.Given the properties of HOXA11-AS as a miR-155 sponge, we further confirmed that SM upregulated the expression of miR-155 in FaDU cells. C-Myc is a transcription factor that regulates cell differentiation and apoptosis, whose mRNA is considered to be targeted by miR-155. We showed that c-Myc expression was downregulated by SM and accompanied by increased apoptosis, which was consistent with the findings of transcriptome sequencing. Yes Further assays demonstrated that SM-induced downregulation of lncRNA HOXA11-AS showed important implications for apoptosis. Furthermore, SM administration suppressed xenograft tumor growth in a xenograft mouse model in vivo. 35903338 HOXA11-AS LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[ binding to EZH2 ] Western Blot//qRT-PCR//RIP//Transwell Assay//ChIP And the higher expression level of HOXA11-AS in HCC patients indicated a lower 5-year survival rate. We also demonstrated that HOXA11-AS could inhibit miR-124 expression by binding to EZH2. Furthermore, overexpression of miR-124 or knockdown EZH2 expression could reverse the HOXA11-AS-induced migration and invasion effects in HCC cells. In summary, the high HOXA11-AS expression in HCC patients is associated with the poor outcome. HOXA11-AS could inhibit miR-124 expression by binding to EZH2 and thus promoted the migration and invasion of HCC cells. And the higher expression level of HOXA11-AS in HCC patients indicated a lower 5-year survival rate. Yes Knockdown of HOXA11-AS in HepG2 and Hep3B cells caused impaired cell invasion and migration abilities.upregulation of HOXA11-AS in MHCC-97H and BEL7402 cells displayed higher invasion and migration capabilities. 31493246 HOXA11-AS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-3619-5p/SALL4 axis) qRT-PCR//Luciferase Report Assay//Western Blot//Transwell Assay HOXA11-AS and SALL4 were upregulated while miR-3619-5p was downregulated in NSCLC tissues and cells. Moreover, miR-3619-5p could directly bind to HOXA11-AS and its inhibition attenuated the inhibitory effect of HOXA11-AS knockdown on progression of NSCLC cells. Furthermore, SALL4 was a direct target of miR-3619-5p and its overexpression reversed the anti-tumor role of miR-3619-5p in NSCLC cells. Besides, HOXA11-AS modulated SALL4 expression via sponging miR-3619-5p. Additionally, silencing HOXA11-AS inhibited tumor growth though upregulating miR-3619-5p and downregulating SALL4. Yes HOXA11-AS knockdown suppressed cell proliferation, migration, invasion, and glycolysis but promoted apoptosis in NSCLC cells. 34050851 HOXA11-AS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation[microRNA-148a-3p/DNMT1 Regulatory Axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay HOXA11-AS expression was notably upregulated and miR-148a-3p expression was conspicuously downregulated in NSCLC tissues and cells. HOXA11-AS facilitated NSCLC tumorigenesis through miR-148a-3p/DNMT1 axis in vitro and in vivo, deepening our understanding of the molecular basis of HOXA11-AS in the development of NSCLC. Yes HOXA11-AS knockdown curbed NSCLC cell proliferation and promoted cell apoptosis through directly increasing miR-148a-3p expression. 31908486 HOXA-AS2 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines Regulation[miR-15a-5p/HOXA3 Axis] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay Using quantitative real-time polymerase chain reaction, HOXA-AS2 was found to be differentially expressed in PTC tissues and cell lines.Mechanistically, loss-of-function assays showed a positive correlation between HOXA3 and HOXA-AS2 expression. Subcellular fractionation assay results revealed abundant HOXA-AS2 expression in the cytoplasm of PTC cells. Additionally, FOXD2-AS1 was found to upregulate HOXA3 expression by binding to miR-15a-5p. Finally, rescue assays demonstrated the overall function of the HOXA-AS2/miR-15a-5p/HOXA3 axis in PTC progression. These findings will significantly contribute to further research and the development of more efficient treatments for thyroid cancer in the future. Kaplan-Meier analysis indicated that the overall survival rate of patients with higher levels of HOXA-AS2 was lower than those with relatively lower levels. Yes Loss-of-function assays revealed that HOXA-AS2 knockdown inhibited PTC progression by inhibiting cellular proliferation, migration, and invasion and accelerating apoptosis. 30375256 HOXA-AS2 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML cell lines and tissues regulation[suppressing LATS2] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Cell Cycle Assay//ChIP HOXA-AS2 was upregulated in AML cell lines and tissues, and the overexpression of HOXA-AS2 is negatively correlated with the survival of patients. Moreover, more in-depth mechanism studies showed that carcinogenicity of HOXA-AS2 exerted mainly through binding with the epigenetic inhibitor Enhancer of zeste homolog 2 (EZH2) and then inhibiting the expression of Large Tumor Suppressor 2 (LATS2). HOXA-AS2 was upregulated in AML cell lines and tissues, and the overexpression of HOXA-AS2 is negatively correlated with the survival of patients. Yes Silencing HOXA-AS2 can inhibit the proliferation and induce differentiation of AML cells in vitro and in vivo. Overexpressing HOXA-AS2 showed the opposite result. 33268767 HOXA-AS2 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML patients regulation[SOX4/PI3K/AKT pathway ] qRT-PCR This study showed that HOXA-AS2 was overexpressed in AML patients.In conclusion, these findings suggest that HOXA-AS2 probably functions as an oncogene via SOX4/PI3K/AKT pathway and might be a useful biomarker for the prognostic prediction in AML patients, providing a potential therapeutic target for AML. In addition, the increased HOXA-AS2 expression was correlated with higher white blood cell and bone marrow blast counts, unfavorable karyotype classification, more measurable residual disease positivity, and earlier death. There was also a tendency toward inferior survival in patients with high HOXA-AS2 expression, and HOXA-AS2 was an independent prognostic factor among the normal-karyotype AMLs. Yes Furthermore, the results of in vitro study showed that silencing HOXA-AS2 significantly inhibited the growth of leukemic cells by inducing G1/G0-phase arrest and apoptosis. 32369230 HOXA-AS2 LncRNA Homo sapiens Uterine Cervical Neoplasms tissues and cells of cervical cancer Interaction(miR-509-3p/BTN3A1 axis) In Vivo Experiment//Western Blot//Transfection//Tube Formation Assay//qRT-PCR//RIP//FISH//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay The HOXA-AS2 level was found high in tissues and cells of cervical cancer.Angiogenesis of HUVECs was restrained after silencing HOXA-AS2. Additionally, HOXA-AS2 upregulated the BTN3A1 by interaction with miR-509-3p. Yes HOXA-AS2 restrained cell proliferation, migration and invasion. BTN3A1 overexpression rescues the inhibitory effect of silenced HOXA-AS2 on cell phenotypes in cervical cancer. Moreover, xenograft tumour growth in mice was suppressed by HOXA-AS2 depletion and was facilitated by BTN3A1 overexpression. 34240204 HOXA-AS2 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cells Interaction(Notch signaling pathway) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Co-IP//CCK8//qRT-PCR//RIP//FISH//IF//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our study first found that HOXA-AS2 expression was up-regulated in cervical cancer cells. Additionally, luciferase reporter assays were performed to confirm that HOXA-AS2 activated Notch signaling pathway via the mediation of independent recombination signal binding protein for JK (RBP-JK) activity. As we know, Notch intracellular domain (NICD) is associated with RBP-JK in the nucleus to promote target genes in the Notch pathway. Through RNA immunoprecipitation (RIP), RNA pull down, and fluorescent in situ hybridization (FISH) assays, we observed that HOXA-AS2 combined with NICD. Yes Then functional analysis including cell counting kit-8 (CCK-8), colony formation, transwell, and wound healing uncovered that reduction of HOXA-AS2 remarkably impeded cell proliferation and migration in cervical cancer. 34076871 HOXA-AS2 LncRNA Homo sapiens Glioma glioma tissues,cell lines Expression[Regulating RND3] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay HOXA-AS2 expression was increased in glioma tissues and cells.Mechanically, HOXA-AS2 epigenetically inhibited RND3 transcription by binding to EZH2. Moreover, overexpression of RND3 exerted similar tumor-suppressive effects to the depletion of HOXA-AS2. Furthermore, the anti-cancer effects induced by si-HOXA-AS2 were greatly reversed by silencing of RND3. Finally, knockdown of HOXA-AS2 impaired tumor growth in vivo possibly via increasing RND3 expression. High HOXA-AS2 expression was associated with larger tumor size and advanced pathological stage. Yes Functionally, knockdown of HOXA-AS2 suppressed cell proliferation and invasion, and promoted apoptosis. 31819475 HOXA-AS2 LncRNA Homo sapiens Glioma glioma specimens and cells Interaction(miR-302a/KDM2A/JAG1 axis) In Vivo Experiment//Immunoblotting//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Microarray//ELISA//IHC//ChIP We found aberrant upregulation of lncRNA HOXA-AS2, lysine demethylase 2A (KDM2A), and jagged 1 (JAG1) and a downregulation of microRNA-302a (miR-302a) in glioma specimens. Next, RNA immunoprecipitation, chromatin immunoprecipitation, and dual-luciferase reporter gene assay demonstrated that lncRNA HOXA-AS2 upregulated KDM2A expression by preventing miR-302a from binding to its 3'untranslated region. Yes The functional experiments suggested that lncRNA HOXA-AS2 could promote regulatory T (Treg) cell proliferation and immune tolerance, which might be achieved through inhibition of miR-302a and activation of KDM2A/JAG1 axis. 35181676 HOXA-AS2 LncRNA Homo sapiens Glioma Glioma Stem Cells (GSCs) Expression(highly expressed) qRT-PCR//RNA-seq//Cell Apoptosis Assay//Cell Proliferation Assay//ChIP-seq We found that HOXA-AS2 is overexpressed only in aggressive (IDHwt) glioma and GSC lines. ShRNA-based depletion of HOXA-AS2 in GSCs decreased cell proliferation and altered the expression of several hundreds of genes. Integrative analysis revealed that these expression changes were not associated with changes in DNA methylation or chromatin signatures at the promoter of the majority of genes deregulated following HOXA-AS2 silencing in GSCs, suggesting a post-transcriptional regulation. In addition, transcription factor binding motif enrichment and correlation analyses indicated that HOXA-AS2 affects, directly or indirectly, the expression of key transcription factors implicated in GCS biology, including E2F8, E2F1, STAT1, and ATF3, thus contributing to GCS aggressiveness by promoting their proliferation and modulating the inflammation pathway. Yes Integrative analysis revealed that these expression changes were not associated with changes in DNA methylation or chromatin signatures at the promoter of the majority of genes deregulated following HOXA-AS2 silencing in GSCs, suggesting a post-transcriptional regulation. 35563134 HOXA-AS2 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues, cell lines regulation[HOXA-AS2/miR-519/HIF-1α and/or HOXA-AS2/miR-519/PD-L1] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay HOXA-AS2 and HIF-1α were found to be significantly upregulated in NPC tumor tissues, as well as in NPC cell lines. In conclusion, the present study demonstrated that HOXA-AS2/miR-519/HIF-1α and/or HOXA-AS2/miR-519/PD-L1 may be a novel mechanism regulating the progression of NPC, which may facilitate the development of targeted clinical therapy. Yes The overexpression of HOXA-AS2 significantly enhanced NPC progression, including the cell proliferative, migratory and invasive abilities. 32973958 HOXA-AS2 LncRNA Homo sapiens Gallbladder Neoplasms gallbladder carcinoma tissues Interaction(miR-6867/Hippo ) Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay The expression of HOXA-AS2 in gallbladder carcinoma tissues was significantly higher than that in adjacent tissues (p < 0.05). Through software prediction and fluorescein reporter gene detection, it was found that HOXA-AS2 has a binding site with miR-6867, and the two are negatively correlated, that is, the expression of miR-6867 is enhanced after the expression of HOXA-AS2 is downregulated. And the 3'UTR of YAP1 protein in the Hippo signaling pathway binds to miR-6867. Therefore, HOXA-AS2 may affect the expression of YAP1 protein by regulating miR-6867, thereby inhibiting the Hippo signaling pathway and promoting the proliferation and metastasis of gallbladder cancer cells. HOXA-AS2 is abnormally expressed in gallbladder cancer cells. Yes Through cell proliferation and plate clone detection, it was found that silencing HOXA-AS2 inhibited cell proliferation and invasion. 36299503 HOXA11-AS LncRNA Homo sapiens Breast Neoplasms tumor tissues of 56 BC patients Interaction(miR-125a-5p/TMPRSS4) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay HOXA11-AS was upregulated in tumor tissues of 56 BC patients compared to adjacent non-tumor tissues, with high levels being associated with worse overall survival. We identified miR-125a-5p as a target of HOXA11-AS, with miR-125a-5p inhibitors partially restoring the reduction of cell proliferation and metastasis induced by HOXA11-AS silencing. We also determined that miR-125a-5p targeted TMPRSS4 mRNA, with HOXA11-AS knockdown and miR-125a-5p mimics suppressing TMPRSS4. HOXA11-AS was upregulated in tumor tissues of 56 BC patients compared to adjacent non-tumor tissues, with high levels being associated with worse overall survival. Yes Silencing of HOXA11-AS inhibited the proliferation and metastasis of BC cells, leading to cell cycle arrest in G0/G1 and induction of apoptosis. 35106863 HOXA-AS2 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells regulation[miR-509-3p/PBX3 axis] Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, we discovered that HOXA-AS2 was highly expressed in PCa tissues and cells.Rescue experiments certified the facilitated role of HOXA-AS2-miR-509-3p-PBX3 axis in regulating the progress of PCa. Yes HOXA-AS2 depletion obviously influenced cell proliferation, migration, invasion, as well as epithelial-to-mesenchymal transition (EMT) progression. 32519740 HOXA-AS2 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(miR-885-5p/KDM5B) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay HOXA-AS2 expression level was elevated in PCa tissues and cells. HOXA-AS2 competitively adsorbed miR-885-5p, thereby blocking the effect of HOXA-AS2 knockdown by the miR-885-5p inhibitor in PCa cells. Moreover, KDM5B, a target of miR-885-5p, neutralized the function of miR-885-5p in PCa cells. Yes Silencing of HOXA-AS2 suppressed proliferation and migration and facilitated apoptosis in PCa cells. 36404720 HOXA-AS2 LncRNA Homo sapiens Hepatoblastoma HB tissues Interaction(ARID1B/HOXA-AS2/HOXA3 axis) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//IHC//Invasion Assay In our previous study, genome-wide analysis with a lncRNA microarray found that lncRNA HOXA-AS2 was up-regulated in HB. . In conclusion, HOXA-AS2 is significantly overexpressed in HB and the ARID1B/HOXA-AS2/HOXA3 axis plays a critical role in HB tumorigenesis and development. Yes Our data revealed knockdown of HOXA-AS2 increased cell apoptosis and inhibited cell proliferation, migration and invasion in HB. Up-regulation of HOXA-AS2 promoted HB malignant biological behaviours. 33683826 HOXA-AS2 LncRNA Homo sapiens Aortic Aneurysm, Thoracic VSMCs, TAA tissues Interaction(IGF2BP3/KIAA1522) RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Apoptosis Assay//EdU Staining HOXA-AS2 was detected to have significantly high expression in TAA tissues and function as an oncogene to promote proliferation of VSMCs, while inhibiting cell apoptosis (Figure 1, **P < 0.01). HOXA-AS2 was unveiled to bind with miR-520d-3p (Figure 2, *P < 0.05, **P < 0.01) and further up-regulate KIAA1522 to facilitate the growth of VSMCs (Figure 3-4, *P < 0.05, **P < 0.01). HOXA-AS2 was also found to recruit IGF2BP3 to stabilize KIAA1522 mRNA (Figure 5, **P < 0.01). Yes HOXA-AS2 was detected to have significantly high expression in TAA tissues and function as an oncogene to promote proliferation of VSMCs, while inhibiting cell apoptosis (Figure 1, **P < 0.01). 35730141 HOXA5 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Expression[highly expressed] qRT-PCR//Western Blot Consistent with these observations, expression of HOXA5 short RNA was upregulated in advanced colon cancer tissues. Yes Ingenuity Pathway Analysis of differentially expressed genes between HOXA5 short RNA overexpressed and silenced HCT116 cells revealed that HOXA5 short RNA preferentially modified expression of epidermal growth factor (EGF) signal-related genes. 31159758 HOXA11-AS LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines,blood Interaction[SRSF1 ] CCK8//qRT-PCR//Western Blot//Transwell Assay Up-regulation of HOXA11-AS was found in GC tissues, cell lines, and serum samples. HOXA11-AS promotes GC cell proliferation and invasion via SRSF1 and may function as a promising marker in GC. In GC patients, decreased serum HOXA11-AS levels were negatively related with tumor size, TNM stage, and lymph node metastasis. The area under the receiver operating characteristic curve of serum HOXA11-AS in the diagnosis of GC was 0.924 (95%CI: 0.881-0.967; sensitivity, 0.787; specificity 0.978). Results of the Kaplan-Meier survival curves suggested the GC patients with a lower HOXA11-AS level having a better overall survival rate. Yes HOXA11-AS promoted GC cell proliferation and invasion. 31235999 HOXA11-AS LncRNA Homo sapiens Stomach Neoplasms plasma regulation[suppression of HOXA12-AS] qRT-PCR LncRNA HOXA11-AS was upregulated in plasma of gastric cancer cells than in plasma of healthy controls and was inversely correlated with PTCSC3 in plasma of gastric cancer patients. Yes PTCSC3 overexpression led to inhibited, while HOXA11-AS overexpression led to promoted migration and invasion of gastric cancer cells. 32368140 HOXA11-AS LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction( miR-124-3p) Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC//Invasion Assay//Transwell Assay We found HOXA11-AS is up-regulated in GC tissues and can bind with miR-124-3p. Meanwhile, we validated that HOXA11-AS promotes migration and invasion of GC cells via down-regulating miR-124-3p and up-regulating ITGB3 in vivo. Yes Through overexpression/knockdown experiments and function tests in vitro, we demonstrated HOXA11-AS can promote ITGB3 expression by sponging miR-124-3p, consequently enhance the proliferation, migration, and invasion of GC cells. 34715856 HOTAIR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cell lines Interaction[binding to miR-206] Western Blot//Wound Healing Assay//CCK8//FISH//RIP//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining//Transwell Assay RT‐qPCR demonstrated that HOTAIR expression in HNSCC cells was higher than that in HIOEC cells (P < 0.05). HOTAIR regulated HNSCC cell biological functions by binding to miR-206 through STC2. Yes Downregulated HOTAIR or upregulated miR-206 suppressed HNSCC cell proliferation, invasion and migration. 31297902 HOTAIR LncRNA Homo sapiens Parkinson Disease SH-SY5Y cells Interaction(miR-221-3p) Western Blot//qRT-PCR//RIP//MTT//ELISA The results showed that HOTAIR was highly expressed, while miR-221-3p expression was decreased in PD model in vivo and in vitro. In conclusion, HOTAIR attenuated the injury of SH-SY5Y cells induced by MPP+ via miR-221-3p/α-synuclein axis, suggesting the potential therapeutic value of HOTAIR in PD. Yes In SH-SY5Y cells treated with MPP+, the knockdown of HOTAIR increased cell viability and reduced cell apoptosis, the secretion of inflammatory cytokines and oxidative stress reaction, while HOTAIR overexpression led to opposite effects. 35398161 Hpx-202 LncRNA Rattus norvegicus Spinal Cord Injuries ASCI rats Regulation(RAD21/VEGFA) RNA Pull-Down//Western Blot//Transfection//Tunel//qRT-PCR//RIP//Luciferase Report Assay The overexpression of LncRNA MIAT was conducive to the recovery of motor function in ASCI rats and repressed neuronal cell apoptosis and increased neuronal cell viability. Furthermore, the overexpression of LncRNA MIAT in PC12 cells upregulated RAD21 expression by repressing RAD21 protein degradation and further promoted VEGFA transcription to inhibit neuronal cell apoptosis, ultimately improved ASCI. Yes The overexpression of LncRNA MIAT was conducive to the recovery of motor function in ASCI rats and repressed neuronal cell apoptosis and increased neuronal cell viability. 33741460 HCP5 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(MiR-106b-5p/p21 Axis) In Vivo Experiment//ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Significant downregulation of HCP5 was detected in GC tissues. Consistently, overexpression of HCP5 came into an opposite effect. Moreover, we demonstrated that MEF2A could combine with the promoter region of HCP5 and thereby induce HCP5 transcription. Luciferase reporter assays revealed that HCP5 could compete with miR-106b-5p as a competing endogenous RNA (ceRNA) and upregulated p21 expression in GC. Negative correlation was determined between HCP5 expression level and tumor size and overall survival in GC patients. Yes HCP5 depletion had a facilitating impact on proliferation, migration and invasion of GC cells. Consistently, overexpression of HCP5 came into an opposite effect. 33613117 HCP5 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue regulation[Down-Regulation of miR-320] CCK8//qRT-PCR We found that HCP5 was up-regulated in NSCLC and predicted the poor survival of NSCLC patients. Therefore, HCP5 may stimulate the proliferation of NSCLC cells by up-regulating survivin through the down-regulation of miR-320. We found that HCP5 was up-regulated in NSCLC and predicted the poor survival of NSCLC patients. Yes Cell proliferation assay showed that HCP5 and survivin overexpression led to increased, while miR-320 overexpression led to decreased cell proliferation rate. 32104093 HCP5 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Regulation(PI3K/AKT/mTOR signaling) qRT-PCR//Western Blot Our findings revealed that HCP5 expression was at a higher level in ESCC tissues and cells compared to that in control tissues and cells. Furthermore, we found that HCP5 bound with miR-139-5p to upregulate PDE4A via the competing endogenous RNA network in ESCC cells. Importantly, HCP5 was discovered to stimulate the PI3K/AKT/mTOR signaling by regulating the downstream target genes. Yes Additionally, HCP5 promoted ESCC cellular activities by promoting proliferation, migration, invasion ability and stemness characteristics of ESCC cells as well as suppressing cell apoptosis. 34190001 HCP5 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Regulation[ HCP5/miR-139-5p/ZEB1 axis] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expression level of HCP5 in CRC tissues was obviously higher compared to para-carcinoma tissues (P < 0.05). Moreover, overexpression HCP5 was found in CRC cell lines (GEO, HCT116, LOVO and SW620) compared to normal colon cell line (CCD-18CO) (P < 0.05).Overall, the present study indicated that HCP5 played a key regulator in CRC development and progression by targeting HCP5/miR-139-5p/ZEB1 axis, which may serve as a novel therapeutic target for CRC therapy. HCP5 overexpression and of miR-139-5p downregulation were dramatically correlated with low TNM stage, poor differentiation, low tumor depth invasion in CRC patients (P < 0.05). Yes Besides, HCP5 overexpression or ZEB1 knockdown repressed Snail family transcriptional repressor (SNAI) and vimentin expressions, upregulated E-cadherin expression, and inhibited cell proliferation and metastasis (P < 0.05). 30899394 HCP5 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues regulation[miR-299-3p/PFN1/AKT Axis] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of HCP5 had a higher level in colorectal cancer samples and cells by qRT-PCR, comparing with the normal colorectal tissues and human normal colon epithelial cell. The experiments and analyses support our hypothesis that knockdown of lncRNA HCP5 suppresses the progression of colorectal cancer by miR-299-3p/PFN1/AKT axis. Yes It was revealed that knockdown of HCP5 inhibited viabilities, migration and invasion, while inducing apoptosis in SW480 and HCT-116 cells. 32606965 HCP5 LncRNA Homo sapiens Carcinoma, Renal Cell neoplasm tissues regulation[miR-214-3p/MAPK1 axis] qRT-PCR qRT-PCR revealed that HCP5 was enhanced in neoplasm tissues of ccRCC patients and correlated with the metastatic characteristics of RCC.Mechanically, HCP5 inhibited the growth and metastasis of ccRCC cells by regulating miR-214-3p/MAPK1 axis. Yes Over-expression of HCP5 promoted the proliferation, migration and invasion of renal carcinoma cells. The deletion of HCP5 inhibited the proliferation, migration and invasion of RCC in vitro and the metastasis of RCC in vivo. 33380840 HCP5 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-29b-3p/DNMT3A/AKT axis) CCK8//qRT-PCR//FISH//Western Blot In the present study, we demonstrated that lncRNA HCP5 was overexpressed in HCC tissues and cell lines, and these findings were obvious even in metastatic and recurrent cases. Knockdown of HCP5 significantly alleviated cell growth, metastasis, and invasion both in vitro and in vivo through promoting apoptosis and by inactivating the epithelial-mesenchymal transition (EMT) progress. Subsequently, DNMT3A was identified as a downstream regulatory factor of miR-29b-3p, and acted as a participated element of HCC progression by activating AKT phosphorylation. Taken together, our study elucidated for the first time that HCP5 plays a crucial role in HCC via the HCP5/miR-29b-3p/DNMT3A/AKT axis. Yes Moreover, miR-29b-3p has been identified as a negatively regulatory target gene of HCP5, and served as a tumor suppressor of HCC to prevent cell proliferation, migration, and invasion. 34148029 HCP5 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells regulation[lncRNAHCP5/microRNA-525-5p/PRC1 crosstalk ] qRT-PCR//Luciferase Report Assay High expression of lncRNA HCP5 was found in OC tissues and cells. The study suggested that lncRNA HCP5 might promote malignant behaviors of OC cells through the miR-525-5p/PRC1 crosstalk and the Wnt/β-catenin pathway. Yes Silencing of lncRNA HCP5 led to a decrease in cell proliferation, invasion, migration and EMT process. 32511950 HCP5 LncRNA Homo sapiens Urinary Bladder Neoplasms BC samples and cells interaction[Sponging miR-29b-3p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay The results revealed dysregulation of HCP5 and miR-29b-3p in BC samples and cells. The findings in this study supported that lncRNA HCP5 could promote cell invasion and migration by sponging miR-29b-3p in human BC. Yes HCP5 negatively regulated the expression of miR-29b-3p and enhanced cell viability, migration and invasion. 33235469 HCP5 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Regulation[miR-140-5p/SOX4 Axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Our results demonstrated that HCP5 expression was significantly increased in OSCC tissues and cell lines. Mechanistically, we confirmed that HCP5 might serve as a competitive endogenous RNA (ceRNA) for miR-140-5p to alleviate the repression of its downstream target, SOX4, a master regulator of EMT. Furthermore, restoration of miR-140-5p expression diminished the oncogenic effects of HCP5 on OSCC cells. Yes Our results demonstrated that HCP5 expression was significantly increased in OSCC tissues and cell lines. 31849534 HCP5 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(miR-101/EPHA7 ) qRT-PCR//Western Blot HCP5 was up-regulated both in OS tissues and cell lines and high expression of HCP5 was associated to low survival in OS patients.miR-101 was targeted by HCP5 and its expression was decreased in OS. The inhibitor of miR-101 reversed the impact of HCP5 down-regulation on cell proliferation, apoptosis, and metastasis in OS. Ephrin receptor 7 (EPHA7) was proved to be a target of miR-101 and had ability to recover the effects of miR-101 inhibitor in OS. HCP5 was up-regulated both in OS tissues and cell lines and high expression of HCP5 was associated to low survival in OS patients. Yes Down-regulation of HCP5 inhibited cell proliferation, migration, and invasion, suggesting its carcinogenic role in OS. 33439936 HCP5 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(miR-29b-3p-LOXL2 axis) CCK8//qRT-PCR MiR-29b-3p expression was decreased and HCP5 and LOXL2 levels were increased in OS tissues and cell lines. Moreover, transfection with sh-HCP5-1 and sh-HCP5-2 suppressed the malignant biological behavior of OS cells. HCP5 directly targeted miR-29b-3p, and promoted OS proliferation, migration, and invasion via the miR-29b-3p/LOXL2 axis. Yes MiR-29b-3p could directly act on LOXL2 and knockdown of LOXL2 restrained the proliferation, migration, and invasion of OS cells. 35899856 HCP5 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Interaction(miR-216a-5p/CDC42 axis) In Vivo Experiment//IHC//Western Blot//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay Besides, RT-qPCR and western blot assay revealed that elevated HCP5 suppressed miR-216a-5p expression and then up-regulated the expression of CDC42. In contrast, knocking down HCP5 resulted in increased expression of miR-216a-5p and then downregulated the expression of CDC42. Yes The results displayed that the overexpression of HCP5 promoted cervical cancer cell proliferation and migration in vitro, and the elevated HCP5 can also promote tumor growth in vivo. 35399723 HCP5 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-205/ VEGF-A) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay Results showed that HCP5 upregulation was found in glioma tissues and cell lines. miR-205 was downregulated in glioma cells. Knockdown of HCP5 led to miR-205 upregulation and VEGF-A downregulation. miR-205 overexpression exhibited the similar effects as HCP5 downregulation on cell viability and proliferation. And VEGF-A overexpression could reverse the effects of HCP5 downregulation on cell viability and proliferation, as well as tumor growth. Patients with high HCP5 expression showed lower survival probability and shorter survival time. Yes HCP5 downregulation inhibited cell proliferation and migration and mitigated tumor growth. 35769676 HCP5 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Interaction(MicroRNA-128-3p/HCP5) In Vivo Experiment//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay The increased level of HCP5 was observed in NPC tissues. The luciferase assay verified that HCP5 could bind with miR-128-3p. Furthermore, forced expression of miR-128-3p could prevent the function of HCP5 on NPC cells. Yes Silencing of HCP5 prevented tumor progression in vitro and in vivo. 35602292 HCP5 LncRNA Homo sapiens Multiple Myeloma MM tissues Interaction(miR-128-3p/Wnt/β-catenin/cyclin D1 signaling via PLAGL2) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//EdU Staining//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//Bioinformatics Analysis HCP5 was significantly increased in MM. HCP5 regulated PLAGL2 expression by sponging miR-128-3p. PLAGL2 overexpression effectively rescued cells from influences by sh-HCP5 on cell proliferative and apoptotic rates. Additionally, HCP5 knockdown significantly inhibited Wnt/β-catenin/cyclin D1 signaling, and these effects were eliminated by PLAGL2 overexpression. Yes HCP5 knockdown effectively thwarted the proliferative rate and cell cycle of MM cell lines and suppressed tumor growth. 34331612 HCP5 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells regulation[miR-140-5p/CDK8 Axis] CCK8//qRT-PCR//Transwell Assay HCP5 and CDK8 were significantly upregulated in PC tissues and cells, opposite to the expression of miR-140-5p.Downregulation of HCP5 impeded PC progression by downregulating CDK8 via sponging miR-140-5p. Yes High expression of HCP5 contributed to the low survival rate and HCP5 silencing inhibited proliferation, migration, and invasion of PC cells in vitro. Simultaneously, in vivo experiments indicated that downregulation of HCP5 suppressed tumor growth. 32407143 HCP5 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Regulation[miR-203/SNAI axis] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Moreover, HCP5 is overexpressed in tumor tissues of patients with LUAD, specifically in patients with EGFR and KRAS mutations and current smoker. Finally, we demonstrated that upregulation of HCP5 increases the expression of Snail and Slug by sponging the microRNA-203 (miR-203) and promoting epithelial-mesenchymal transition (EMT) in LUAD cells. HCP5 high expression level is positively correlated with poor prognosis of patients with LUAD. Yes We found that HCP5 knockdown obviously inhibited the tumor growth and produced significantly smaller tumors compared with control mice (Figure ​(Figure44A-D). 31131047 HCP5 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues,cell lines Interaction[sponging miR-219a-5p] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//RNA-seq//IHC//Transwell Assay We observed that HCP5 was upregulated in TNBC cell lines and specimens. RNA sequencing and antibody array suggested that HCP5 achieves its functions through regulating apoptosis pathway. Bioinformatics, luciferase and RIP experiments proved that both HCP5 and BIRC3 could competitively bind to miR-219a-5p. Increased BIRC3 and decreased miR-219a-5p were observed in TNBC tissues and cell lines. We then performed gain- and loss-of-function studies as well as rescue experiments in TNBC cells. The decrease of proliferation and migration due to HCP5 knockdown could be rescued when miR-219a-5p inhibitor or BIRC3 was transfected and vice versa. Our study suggested that lncRNA HCP5 promotes TNBC progression as a ceRNA to regulate BIRC3 by sponging miR-219a-5p. In a word, we revealed a new signaling pathway to mediate TNBC, and provided HCP5 as a new target for improving treatment of TNBC. Yes HCP5 knockdown induced TNBC cell apoptosis, and inhibited cell proliferation and orthotopic xenograft tumor growth. 31215169 HCP5 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC cell lines Interaction(miR-216a-5p/ZEB1) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay In this study, HCP5 expression levels were confirmed to be prominently raised in LSCC cell lines. Furthermore, miR-216a-5p was confirmed to sponge HCP5, and its expression was prominently downregulated in LSCC cell lines and upregulated in HCP5-silenced LSCC cell lines. miR-216a-5p overexpression downregulated the cell proliferation and migration and invasive ability of LSCC cells. Additionally, the protein level of zinc finger E-box binding homeobox 1 (ZEB1), one target gene of miR-216a-5p, was highly expressed in LSCC cell lines, and its expression level was downregulated by HCP5 knockdown and miR-216a-5p overexpression. Yes HCP5 knockdown reduced cell proliferation and migration and invasive ability of LSCC cell lines. 36248798 HCP5 LncRNA Homo sapiens Stomach Neoplasms GC cell lines Interaction(DDX21) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Using RT-qPCR analysis, we found that lncRNA HCP5 was differentially expressed in GC cell lines. Mechanistically, RNA binding protein immunoprecipitation and dual luciferase reporter assay confirmed the interaction between lncRNA HCP5 and DDX21. The effects of lncRNA HCP5 overexpression the proliferation, migration and invasion of GC cells were partly rescued by DDX21 silencing. Yes CCK-8, wound healing and transwell assay indicated that the proliferation, migration and invasion of gastric cancer cells were inhibited by downregulation of lncRNA HCP5 and lncRNA HCP5 overexpression exhibited the opposite effects in gastric cancer cells. 33505109 HCP5 LncRNA Homo sapiens Stomach Neoplasms GC cell lines Interaction(miR-299-3p/SMAD5 axis) Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Invasion Assay In our study, lncRNA HCP5 was highly expressed in GC cell lines compared with normal gastric epithelial cell. Interestingly, SMAD5 is identified as the downstream target of miR-299-3p, and its expression was inhibited by miR-299-3p. Yes LncRNA HCP5 silencing inhibited AGS cells proliferation, migration, and invasion, while promoted cell apoptosis. Moreover, miR-299-3p downregulation could abolish the effect of HCP5 knockdown on cellular behaviors of AGS cells. 33371778 HCP5 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cells regulation[miR-140-5p/IGF1R pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The expression of HCP5 was significantly upregulated in ccRCC tissues and cells. Hence, the HCP5/miR-140-5p/IGF1R pathway might be a promising therapeutic target in ccRCC. Moreover, patients with high HCP5 expression level had unfavorable overall survival (OS) and progression-free survival (PFS) compared to those with low HCP5 expression. Yes Additionally, HCP5 knockdown led to the prohibition of ccRCC cell proliferation, colony formation, migration, and invasion; the promotion of cell cycle arrest at G0-G1 and apoptosis in vitro; and the inhibition of tumor growth in vivo. 32271414 hcR1445 CircRNA Homo sapiens Ovarian Neoplasms OC cells and tissues Interaction(miR-576-5p/SFRP1 axis) Flow Cytometry//RIP//Proliferation Assay//IF//PCR//IP//Transwell Assay hcR1445 level was declined in OC cells and tissues. hcR1445 reduced cellular invasion, proliferation, and migration by blocking the ability of miR-576-5p to upregulate SFRP1 expression and consequently prohibit WNT/β-catenin signal transduction. hcR1445 upregulation suppressed OC growth, development, and intraperitoneal metastasis in vivo. Yes hcR1445 reduced cellular invasion, proliferation, and migration by blocking the ability of miR-576-5p to upregulate SFRP1 expression and consequently prohibit WNT/β-catenin signal transduction. hcR1445 upregulation suppressed OC growth, development, and intraperitoneal metastasis in vivo. 36259450 HHIP-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(HHIP/CELF2) CCK8//qRT-PCR//Transwell Assay//Western Blot The results showed that HHIP-AS1 and HHIP levels are downregulated in NSCLC, and that low HHIP-AS1 and HHIP expression is associated with poor outcomes. HHIP-AS1 enhances HHIP expression and stability, and this effect is mediated by CELF2. HHIP silencing attenuates the suppressive roles of HHIP-AS1 in proliferation, migration, and invasion. The results showed that HHIP-AS1 and HHIP levels are downregulated in NSCLC, and that low HHIP-AS1 and HHIP expression is associated with poor outcomes. Yes HHIP-AS1 overexpression represses cell proliferation, migration, and invasion in NSCLC. 36374812 HGBC LncRNA Homo sapiens Gallbladder Neoplasms GBC tissue,cell lines Regulation[miR-502-3p/SET/AKT axis] FISH//Luciferase Report Assay//RNA Pull-Down//RIP We found that lncRNA-HGBC was upregulated in GBC and its upregulation could predict poor survival. LncRNA-HGBC specifically bound to RNA binding protein Hu Antigen R (HuR) that in turn stabilized lncRNA-HGBC. LncRNA-HGBC functioned as a competitive endogenous RNA to bind to miR-502-3p that inhibits target gene SET. Overexpression, knockdown or mutation of lncRNA-HGBC altered the inhibitory effects of miR-502-3p on SET expression and downstream activation of AKT. Clinically, lncRNA-HGBC expression was negatively correlated with miR-502-3p, but positively correlated with SET and HuR in GBC tissue. We found that lncRNA-HGBC was upregulated in GBC and its upregulation could predict poor survival. Yes Overexpression or knockdown of lncRNA-HGBC in GBC cell lines resulted in increased or decreased, respectively, cell proliferation and invasion in vitro and in xenografted tumors. 31752906 HERH-4 LncRNA Homo sapiens Carcinoma, Hepatocellular advanced HCC cells Interaction(miR-29b/c /CCNA2) qRT-PCR//Northern Blot//ChIP//FISH Two lncRNAs, the highly expressed lncRNA in recurrent HCC (HERH)-1 and HERH-4, were upregulated in the advanced HCC cells. HERH-4 acted as an miR-29b/c sponge to facilitate CCNA2 protein translation through a competing endogenous RNA (ceRNA) pathway. Yes HERH-1/4 enhanced proliferation and promoted DNA replication and G1-S transition during the cell cycle in HCC cells. 34445994 HERH-1 LncRNA Homo sapiens Carcinoma, Hepatocellular advanced HCC cells Interaction(CREB1) qRT-PCR//Northern Blot//ChIP//FISH Two lncRNAs, the highly expressed lncRNA in recurrent HCC (HERH)-1 and HERH-4, were upregulated in the advanced HCC cells. HERH-1 interacted with the transcription factor CREB1. CREB1 enhanced cyclin A2 (CCNA2) transcription, depending on HERH-1-CREB1 interaction. Yes HERH-1/4 enhanced proliferation and promoted DNA replication and G1-S transition during the cell cycle in HCC cells. 34445994 HEIH LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR//MTT//Tunel//Transwell Assay Compared with Control group, the expression of lncRNA-HEIH rose significantly in GC tissues Yes Compared with those in si-NC group, the proliferation of HGC-27 cells was suppressed (p<0.05), while the apoptosis of HGC-27 cells was promoted (p<0.01) in si-HEIH group. (4) The invasion of HGC-27 cells was remarkably inhibited in Si-HEIH group than si-NC group (p<0.05). 33015781 HEIH LncRNA Homo sapiens Stomach Neoplasms GC patients and MKN45 and AGC cells Expression(highly expressed) CCK8//qRT-PCR//Survival Analysis The lncRNA-HEIH was highly expressed in both GC tissues and GC cell lines. Patients with high HEIH expression were associated with medium-high differentiation (p = 0.0058), distant metastasis (M, p = 0.0378), lymph node metastasis (N, p = 0.0083), and a deeper tumor invasion (T, p = 0.0204). The elevated expression levels of HEIH in GC patients were associated with a worse prognosis compared to GC patients with low HEIH expression. This finding was supported by the parameters overall survival (p = 3.3e-06), first progression (p = 0.00028), and postprogression (p = 1.5e-08). Yes Downregulation of HEIH expression inhibited cell proliferation, enhanced oxaliplatin sensitivity, and induced the expression of p53 in MKN45 and AGC cells. 33877891 HEIH LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines Interaction[Wnt/β-catenin pathway] qRT-PCR The expression of HEIH was upregulated in breast cancer tissue samples and cell lines. Moreover, a negative relationship existed between HEIH and miR-200b, and HEIH regulated breast cancer development via regulating miR-200b. Pre-leukemia transcription factor 3 (PBX3) was verified as a functional target of miR-200b, and miR-200b regulated the malignant behaviors of breast cancer cells through targeting PBX3. Furthermore, suppression of HEIH inhibited the activation of Wnt/β-catenin pathway, which was remarkably reversed after suppression of HEIH and inhibition of miR-200b synchronously. Our results reveal that HEIH may contribute to breast cancer development via modulation of microRNA-200b/axis and inducing the activation of Wnt/β-catenin pathway. Further studies are still required to confirm our findings. Yes Suppression of HEIH inhibited cell viability, promoted cell apoptosis, and decreased migration and invasion in MDA-MB-231 cells. 31526439 HEIH LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines Expression[highly expressed] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Cell Viability Assay//EdU Staining//Transwell Assay The results indicated high expression levels of HEIH in human breast cancer tissues, and its expression was positively associated with malignancy status and poor disease prognosis. The results indicated high expression levels of HEIH in human breast cancer tissues, and its expression was positively associated with malignancy status and poor disease prognosis. Yes Following HEIH knockdown, the proliferative and metastatic activity of MDA?MB?231 cells was decreased, whereas the induction of cell apoptosis was increased. 32945377 HEIH LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Expression[highly expressed] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay In our study, we confirmed the elevated expression of HEIH in NSCLC tissues and cell lines compared with the normal ones. Yes Moreover, overexpression of HEIH accelerated the cell migrating rate and increased the invasive cell number according to the results of a wound healing assay and transwell assay. 30230600 HEIH LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines regulation[miR-4458/PBX3] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay HEIH was confirmed to be upregulated in both ESCC tissues and cell lines. The present study clarified that HEIH regulated ESCC progression by suppressing miR-4458 and upregulating PBX3. Yes Functionally, we noticed that depletion of HEIH restrained ESCC cell viability, and invasion capability. 32449803 HEIH LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues,cell lines regulation[miR-3619-5p/CTTNBP2 axis] Western Blot//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay Herein, HEIH expression was found to be up-regulated in ovarian cancer tissues (n = 25; twofold higher than normal tissues, P < 0.05) and cell lines (sixfold higher than normal ovarian epithelial cell line on average, P < 0.05), and high HEIH expression predicted poor prognosis (survival rate is about 25% after 40 mo; P < 0.05). Herein, HEIH expression was found to be up-regulated in ovarian cancer tissues (n = 25; twofold higher than normal tissues, P < 0.05) and cell lines (sixfold higher than normal ovarian epithelial cell line on average, P < 0.05), and high HEIH expression predicted poor prognosis (survival rate is about 25% after 40 mo; P < 0.05). Yes Furthermore, we found that HEIH facilitated tumor growth in vivo by regulating CTTNBP2 expression (P < 0.05). 33110047 HEIH LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cell lines Regulation[miR-4458/SOCS1 axis] qRT-PCR//MTT//Luciferase Report Assay//Western Blot In our study, we found that HEIH was overexpressed in TNBC tissues and cell lines compared with adjacent normal mammary tissues and normal mammary epithelial cell line, respectively.Furthermore, we observed that HEIH and miR-4458 had a high correlation score in TNBC tissues, and HEIH directly binds to miR-4458, and negatively regulates miR-4458 expression in TNBC cells. Finally, we found that TNBC patients with tumor size ≥ 5 cm or advanced clinical stage had higher levels of HEIH expression than patients with tumor size < 5 cm or early clinical stage. Yes The in vitro cell proliferation and apoptosis assays suggested down-regulation of HEIH inhibited TNBC cell proliferation and promoted apoptosis through regulating miR-4458/SOCS1 axis. 31456112 HEIH LncRNA Homo sapiens Triple Negative Breast Neoplasms regulation[ miR-939-5p/NOS2/NO axis] qRT-PCR In contrast, HEIH was found to be markedly upregulated in TNBC patients and showed a modulatory role on miR-939-5p/NOS2/NO axis. Yes inally, knocking down of HEIH resulted in improvement of immunogenic profile of TNBC cells through inducing MICA/B and suppressing the immune checkpoint inhibitor PDL1. In the same context, knockdown of HEIH resulted in the alleviation of the immune-suppressive TME by repressing interleukin-10 and tumor necrosis factor-α levels. 33368266 HEIH LncRNA Homo sapiens esophageal carcinoma EC tissues regulation[upregulating microRNA-185 and downregulating KLK5] RNA Pull-Down//Western Blot//ISH//qRT-PCR//FISH//Luciferase Report Assay//H&E Staining//IHC//EdU Staining//Transwell Assay Results from this study indicated that HEIH and KLK5 were elevated and miR-185 was declined in EC. Collectively, we reveal that HEIH depletion dampens EC progression by upregulating miR-185 and downregulating KLK5, which provides novel treatments for EC. High HEIH and KLK5 indicated worse prognosis and high miR-185 suggested better prognosis of EC patients. Yes Depleting HEIH or restoring miR-185 suppressed the malignant phenotypes of EC cells, and delayed tumor growth in EC mice. 33223519 HEIH LncRNA Homo sapiens Cholangiocarcinoma CHOL tissues and cells regulation[miR-98-5p/HECTD4] qRT-PCR//Luciferase Report Assay//RIP According to the results, HEIH expression was up-regulated in CHOL tissues and cells. In conclusion, HEIH promoted CHOL tumorigenesis and progression by miR-98-5p/HECTD4 axis, which opens up a new insight for CHOL therapeutics. Yes Functionally, knockdown of HEIH attenuated cell proliferation, migration and invasion. 32062383 HEIH LncRNA Homo sapiens Retinoblastoma retinoblastoma tissues and cell lines regulation[miR-194-5p/WEE1 Axis] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that HEIH was up-regulated in retinoblastoma tissues and cell lines. Furthermore, high level of HEIH was associated with TNM stage, optic nerve invasion and choroidal invasion of patients with retinoblastoma. Yes Functional studies showed that HEIH knockdown significantly suppressed retinoblastoma cell proliferation, migration and invasion. 33262604 HEIH LncRNA Homo sapiens stomach carcinoma GC tumour tissues and matched para-tumour tissues Interaction(miR-214-3p ) Western Blot//Transfection//qRT-PCR//Cell Proliferation Assay//Transwell Assay The expression of HEIH in GC tissues was higher than in adjacent normal tissues. The expression of HEIH was upregulated in MKN-45, NCL-N87, KATO III cell lines compared within normal gastric epithelial cells. We also proved that miR-214-3p was the direct target of lncRNA HEIH, and that overexpression of miR-214-3p could reverse the effects of HEIH. Yes Knockdown of lncRNA HEIH significantly decreased the number of migrated and invaded cells. Additionally, downregulation of HEIH could increase GC cell apoptosis compared with the non-specific control (NC) group.  33226411 HECW1 CircRNA Homo sapiens Spinal Cord Injuries PC12 cells Interaction(miR-3551-3p/LRRTM1 Axis) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//PCR The expression of circ Hecw1, TNF-α, IL-6, and IL-1β in LPS-triggered PC12 cells and the expression of miR-3551-3p and IL-10 were significantly decreased.Our study revealed that circHecw1 regulates SCI neuronal cell inflammation imbalance by regulating the miR-3551-3p/LRRTM1 signaling. Yes Knockdown of circHecw1 promoted proliferation and inhibited apoptosis and reduction in the inflammatory cytokine expression. 35699802 HDAC1 LncRNA Homo sapiens Multiple Myeloma myeloma cells Interaction(Slug) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay In the present study, the expression of class I HDACs in myeloma cells and tissues was evaluated. Mechanistically, the results revealed that HDAC1 regulated the mRNA stability of Slug, while it had no effect on its transcription or nuclear export. Yes Targeted inhibition of HDAC1 suppressed the migration of myeloma cells. Of the assessed transcription factors, small interfering (si)‑HDAC1 decreased the expression of Slug. 34738621 HCP5 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues and cell lines Interaction[miR‑4656 ] CCK8//qRT-PCR//Western Blot n the present study, we found the overexpressed expression of HCP5 in prostate cancer tissues and cell lines via RT‑qPCR analysis.Functional experiments demonstrated that HCP5 acted as a competing endogenous RNA (ceRNA) to sponge miR‑4656. Ectopic expression of HCP5 decreased the expression of miR‑4656 in prostate cancer cells. MiR‑4656 was found to be decreased in prostate cancer tissues and was negatively correlated with the expression of HCP5. Further luciferase reporter assay revealed that miR‑4656 was able to bind the 3'‑untranslated region (3'‑UTR) of the cell migration inducing hyaluronidase 1 (CEMIP) and suppressed the expression of CEMIP. Consistent with the negative regulation of miR‑4656 by HCP5, western blot analysis uncovered that overexpression of HCP5 upregulated the abundance of CEMIP in prostate cancer cells. The CCK‑8 assay showed that depletion of CEMIP significantly inhibited the HCP5‑promoted proliferation of prostate cancer cells. Collectively, our data provide a novel mechanism by which HCP5 regulates the progression of prostate cancer. High expression of HCP5 was positively correlated with the metastasis of prostate cancer. Yes Downregulation of HCP5 inhibited the proliferation, colony formation and induced apoptosis of prostate cancer cells. 31746434 HCP5 LncRNA Homo sapiens Thyroid Carcinoma, Anaplastic ATC tissues Interaction[sponging miR-128-3p ] qRT-PCR//MTT//RIP Besides, HCP5 expression level was increased in ATC tissues when compared with adjacent normal tissues. MiR-128-3p was predicted to be a target gene of HCP5. The expression level of miR-128-3p was significantly decreased in ATC cells and tissues, as compared to Nthy-ori 3-1 cells and adjacent normal tissues, respectively. MiR-128-3p overexpression reduced ATC cell viability, and induced cell apoptosis. HCP5 directly bound to miR-128-3p and regulated the expression of miR-128-3p in ARO and SW1736 cells. Furthermore, the effects of HCP5 knockdown on ATC cell viability and apoptosis were attenuated by the inhibitor of miR-128-3p. These findings suggested that knockdown of HCP5 exerted anti-tumor effect via sponging miR-128-3p in ATC, which might provide a potential approach for the treatment of ATC. Yes Knockdown of HCP5 reduced cell viability, while elevated apoptotic rate and caspase-3/7 activity in ARO and SW1736 cells. 31102936 HOTAIR LncRNA Homo sapiens Leukemia, Myeloid, Acute AML tissues,cell lines Interaction[HOXA5 ] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining//ChIP LncRNA HOTAIR was found to be upregulated in AML cells and tissues.Furthermore, HOTAIR was observed to recruit Dnmt3b and to increase HOXA5 promoter methylation. Moreover, silencing HOTAIR and upregulating HOXA5 were found to induce apoptosis and reduce proliferation of AML cells in vivo. Yes With silencing of HOTAIR and overexpression of HOXA5, AML cell proliferation was decreased while the apoptosis was induced. 31168296 HCG18 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cells Interaction( miR-152-3p/RAB14 ) In Vivo Experiment//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay It was found that HCG18 expression was highly expressed in ccRCC tissues and cells, and patients with high expression of HCG18 had a short overall survival time. In addition, miR-152-3p was confirmed as a downstream target of HCG18 and was inversely regulated by HCG18, and RAB14 was a target of miR-152-3p. Functional assays demonstrated that miR-152-3p silencing or RAB14 addition abolished the inhibitory effects of HCG18 knockdown on ccRCC progression. It was found that HCG18 expression was highly expressed in ccRCC tissues and cells, and patients with high expression of HCG18 had a short overall survival time. Yes Moreover, HCG18 depletion attenuated ccRCC cell viability, migration and invasion. 33732021 HCG18 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LHSCC tissues Interaction(miR‑133/FGFR1 ) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Bioinformatics Analysis//Transwell Assay HCG18 and FGFR1 were upregulated, but those of miR?133b were downregulated in LHSCC tissues.HCG18 could competitively bind with miR‑133b. Moreover, the miR‑133b inhibitor promoted cell viability, migration, invasion and the expression levels of Bcl‑2, p‑PI3K and p‑AKT, but inhibited the expression levels of p53 and Bax, which were abrogated by shHCG18. miR‑133b could competitively bind with FGFR1, and the miR‑133b mimic decreased the expression level of FGFR1 in transfected LHSCC cells. Yes Short hairpin RNA (sh) HCG18 and miR?133b mimic inhibited LHSCC cell viability, while enhancing miR?133b expression. 34878161 HCG18 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Regulation(miR-188-5p/FOXC1 Axis) Western Blot//Transfection//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay HCG18 expression was elevated in OS tissues, and enhanced HCG18 expression was related to metastasis. HCG18 silencing repressed the viability, migration and invasion of OS cells. Moreover, HCG18 interacted with miR-188-5p. MiR-188-5p up-regulation repressed cell viability, invasion and migration in OS cells. FOXC1, a known target of miR-188-5p, was negatively modulated by miR-188-5p. Furthermore, miR-188-5p inhibition or FOXC1 over-expression partially abolished the reduced of cell viability, invasion and migration mediated by HCG18 silencing in OS cell lines. This study revealed that HCG18 knockdown repressed the viability, invasion and migration of OS cells by targeting miR-188-5p and regulating FOXC1 expression. Thus, HCG18/ miR-188-5p/FOX may be a hopeful target for OS therapy. HCG18 expression was related to metastasis. Yes HCG18 silencing repressed the viability, migration and invasion of OS cells. Moreover, HCG18 interacted with miR-188-5p. MiR-188-5p up-regulation repressed cell viability, invasion and migration in OS cells. 34041718 HCG18 LncRNA Mus musculus Diabetic Neuropathies DPN model and HG-induced macrophages Interaction(miR-146a/TRAF6 axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//ELISA LncRNA HCG18 was highly expressed in DPN model and HG-induced macrophages. In addition, miR-146a was identified as a target of lncRNA HCG18. Overexpression of miR-146a reversed the promoting effect of HCG18 on M1 macrophage polarization. Simultaneously, TRAF6 was a target gene of miR-146a TRAF6 expression was positively modulated by HCG18 and was negatively modulated by miR-146a. Yes The levels of inflammatory factors (TNF-α, IL-1β, and IL-6) were elevated in DPN model. The expression of M1 markers (CD11c and iNOS) was visibly up-regulated in DPN model and was positively correlated with HCG18 expression. LncRNA HCG18 facilitated M1 macrophage polarization. 32996080 HCG15 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(USF1-mediated ZNF641) qRT-PCR TCGA data revealed that HCG15 was markedly overexpressed and closely associated with the poor prognosis of HCC. Collectively, our study demonstrated that HCG15 was a new HIF-1 target gene and played a tumor-promoting role in HCC cells by enhancing USF1-mediated ZNF641 transcription. TCGA data revealed that HCG15 was markedly overexpressed and closely associated with the poor prognosis of HCC. Yes HCG15 knockdown prominently suppressed the migration, invasion and proliferation of Hep3B and Huh7 cells. HCG15 overexpression markedly enhanced the proliferation and mobility of Huh7 cells. 35427894 HCG15 LncRNA Homo sapiens Myocardial Reperfusion Injury cardiomyocyte Regulation( NF-κB/p65 and p38 pathways) In Vivo Experiment//Western Blot//qRT-PCR//RNA-seq//Cell Apoptosis Assay//ELISA HCG15, one of the differentially expressed lncRNAs, was verified to have the highest correlation with cTnT by qRT-PCR, and it also contributed to the diagnosis of AMI by receiver operating characteristic (ROC) analysis. We also confirmed that HCG15 was mainly wrapped in exosomes from AC16 cardiomyocytes under hypoxia, which contributed to cardiomyocyte apoptosis, the release of inflammatory factors, and inhibition of cell proliferation via the activation of the NF-κB/p65 and p38 pathways, whereas suppressing the expression of HCG15exerted opposite effects. Yes . Upregulation of HCG15 expression facilitated cardiomyocyte apoptosis and inflammatory cytokine production and inhibited cell proliferation. In addition, Overexpression of HCG15 aggravated cardiac IR injury in C57BL/6J mice. T 34707098 HCG11 LncRNA Homo sapiens Stomach Neoplasms GC tissues,cell lines Regulation[miR-1276/CTNNB1 and Wnt signaling pathway] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay HCG11 was discovered highly expressed in GC tissues and cells. Overall, HCG11 accelerated proliferation and migration in GC through miR-1276/CTNNB1 and Wnt signaling pathway, revealing that HCG11 could be a brand new target for GC. Yes Depletion experiments were used to evaluate HCG11 silence on cell proliferation, migration and apoptosis. 31889902 HCG11 LncRNA Homo sapiens Stomach Neoplasms GC cells Interaction(miR-942-5p/BRMS1 Axis) Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Results showed that LncRNA HCG11 was downregulated in GC cells. In addition, lncRNA HCG11 was found to act as a molecular sponge of miR-942-5p. Furthermore, miR-942-5p promoted GC progression by suppressing lncRNA HCG11 expression. Besides that, BRMS1 was confirmed as a direct target of miR-942-5p. More importantly, breast cancer metastasis suppressor 1 (BRMS1) inhibited GC progression by upregulating lncRNA HCG11 and downregulating miR-942-5p. Yes Functionally, overexpression of HCG11 inhibited GC cell proliferation, migration, and invasion. 34054958 HCG11 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-522-3p,SOCS5] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Downregulation of lncRNA HCG11 and upregulation of miR-522-3p were found in NSCLC tissues and cells, and abnormal expressions of lncRNA HCG11 and miR-522-3p were related to adverse clinical outcomes of NSCLC patients. LncRNA HCG11 inhibits cell viability, migration and invasion in NSCLC by functioning as a ceRNA of miR-522-3p to upregulate SOCS5. Yes Functionally, lncRNA HCG11 inhibited cell viability, migration and invasion in NSCLC by downregulating miR-522-3p. 32844573 HCG11 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissues Interaction(miR-875/SATB2 axis) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//IHC//Invasion Assay The present study showed that the expression levels of HCG11 were reduced in tumor tissues compared with adjacent normal tissues, and similar results were obtained in experiments using lung cancer cell lines. In conclusion, HCG11 was shown to suppress the malignant properties of NSCLC cells by targeting a miR‑875/SATB2 axis, and may therefore be a promising target for the treatment of NSCLC. Additionally, patients with high HCG11 expression had an increased survival rate compared with patients with low HCG11 expression. Yes Further studies have shown that overexpression of HCG11 inhibited NSCLC cell proliferation in vitro and in vivo. 34080031 HCG11 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Regulation[miR-26a-5p/ATG12 axis] Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//MTT//Invasion Assay//Transwell Assay The enrichment of HCG11 was enhanced in HCC tissues and cells and was negatively related to the prognosis of HCC patients. LncRNA HCG11 accelerated the proliferation, metastasis, and autophagy while impeded the apoptosis of HCC cells via HCG11/miR-26a-5p/ATG12 axis. HCG11 might be a potential therapeutic target for the treatment of HCC. Yes HCG11 interference suppressed the proliferation, metastasis, and autophagy while promoted the apoptosis of HCC cells. HCG11 promoted the growth of murine xenograft tumor and autophagy through miR-26a-5p/ATG12 axis in vivo. 31858580 HCG11 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and OC cell lines regulation[modulating miR-144-3p/PBX3] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The upregulated of HCG11 was observed in OC tissues and OC cell lines.These data displayed that the knockdown of HCG11 prevented cell progression in OC by sponging miR-144-3p and downregulating PBX3. Yes Functionally, the knockdown of HCG11 prevented cell viability of SKOV3 cells, while miR-144-3p inhibitor abrogated the suppressor on cell progression. Furthermore, PBX3 was verified to be a target gene of miR-144-3p. In addition, PBX3 knockdown prevented the cell progression of SKOV3 cells. 33215418 HCG11 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cells Interaction( miR-1270/PTEN) qRT-PCR//Bioinformatics Analysis//Western Blot HCG11 was weakly expressed in ovarian cancer and functioned as a tumor suppressor in ovarian cancer by retarding cell proliferation, migration, and EMT. Besides, HCG11 could bind to miR-1270 and PTEN was a target gene of miR-1270. Mechanically, HCG11 competitively bound with miR-1270 to upregulate PTEN. From rescue experiments, HCG11 impeded AKT/mTOR pathway to retard ovarian cancer cell growth by miR-1270/PTEN. Yes HCG11 was weakly expressed in ovarian cancer and functioned as a tumor suppressor in ovarian cancer by retarding cell proliferation, migration, and EMT. 35016264 HCG11 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cell Interaction(miR-455-5p) qRT-PCR//MTT//RIP Knockdown of HCG11 increased OSCC cell proliferation, as indicated by enhanced cell vitalities over time, increased G1/S transition and Ki67 levels. Furthermore, lncRNA HCG11 was shown to negatively regulate miR-455-5p and miR-455-5p targeted PTPRS directly to affect its downstream indicators, which can further modulate OSCC cell proliferation and growth. Yes Knockdown of HCG11 increased OSCC cell proliferation, as indicated by enhanced cell vitalities over time, increased G1/S transition and Ki67 levels. 33151000 HCG11 LncRNA Homo sapiens Osteosarcoma OS tissues Interaction(miR-942-5p/IGF2BP2 Axis) qRT-PCR//RNA Pull-Down//RIP Our data revealed that HCG11 expression is decreased in OS, which is a result of transcriptional repression of YY1. HCG11 can raise p27 Kip1 expression via binding to miR-942-5p and IGF2BP2, and p27 Kip1 acts as a key effector for HCG11 exerting biological functions. Low HCG11 level is closely associated with larger tumor size and shorter overall survival of OS patients. Yes HCG11 negatively regulates cell proliferation, cell cycle, DNA replication in vitro and tumor growth in vivo. 34518440 HCG11 LncRNA Homo sapiens Osteosarcoma OS tissues Interaction(miR-1245b-5p/PKP2 axis) qRT-PCR//RIP We found that the lncRNA HCG11 was significantly upregulated in OS. In conclusion, the HCG11/miR-1245b-5p/PKP2 axis promotes OS expression by promoting cell proliferation, migration, and invasion, and inhibiting apoptosis. Yes LncRNA HCG11 silencing inhibits OS progression by repressing cell proliferation, migration, and invasion, and promoting cell apoptosis. 34949159 HCG11 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines interaction[sponging miR-942-5p and targeting GFI1] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Long noncoding RNA HCG11 was downregulated in CC. Long noncoding RNA HCG11 increased the expression of GFI1 and suppressed cell proliferation and invasion by acting as a miR-942-5p sponge. Yes Functional assays demonstrated that lncRNA HCG11 inhibited CC cell proliferation and invasion. Finally, the overexpression of lncRNA HCG11 suppressed the proliferation and metastasis of CC cells in vivo. 32794340 HCG11 LncRNA Homo sapiens Glioma glioma tissues Regulation[miR-496/CPEB3 axis] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP HCG11 was expressed at low level in glioma samples compared with normal samples.HCG11 was predominantly enriched in the cytoplasm of glioma cells and acted as a competing endogenous RNAs (ceRNAs) by sponging micro-496 to upregulate cytoplasmic polyadenylation element binding protein 3 (CPEB3). CEPB3 and miR-496 involved in HCG11-mediated glioma progression. Yes Overexpression of HCG11 efficiently suppressed cell proliferation, induced cell cycle arrest and promoted cell apoptosis. 31310044 HCG11 LncRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-590-3p/CADM2 molecular axis) Western Blot//Transfection//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU HCG11 expression was lower in glioma tissues compared with that in paracancerous tissues, and its expression level was negatively correlated with WHO tumor stage.In addition, compared with in astrocyte cell line, the expression of HCG11 was lower in glioma cells. Functional experiments showed that HCG11 inhibited glioma cells migration and proliferation, while miR-590-3p facilitated these processes. Acting as a competitive endogenous RNA, HCG11 adsorbed miR-590-3p and upregulated the expression of CADM2, the target gene of miR-590-3p. HCG11 expression was lower in glioma tissues compared with that in paracancerous tissues, and its expression level was negatively correlated with WHO tumor stage. Yes Functional experiments showed that HCG11 inhibited glioma cells migration and proliferation, while miR-590-3p facilitated these processes. 35279660 HCG11 LncRNA Homo sapiens Glioma glioma cells and tissues Interaction(MicroRNA-144COX-2 axis) qRT-PCR In general, down-regulation of long non-coding RNA-HCG11 can regulate the microRNA-144COX-2 axis in glioma, thus reducing the proliferation rate of glioma cells and improving the apoptosis rate of glioma cells. Yes In general, down-regulation of long non-coding RNA-HCG11 can regulate the microRNA-144COX-2 axis in glioma, thus reducing the proliferation rate of glioma cells and improving the apoptosis rate of glioma cells. 35818213 HCG18 LncRNA Homo sapiens Melanoma melanoma tissues and cells Interaction( miR-324-5p/CDK16 axis) RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay HCG18 was highly expressed in melanoma tissues and cells.HCG18 was confirmed to be a sponge of miR-324-5p, and CDK16 might be a downstream gene of miR-324-5p. HCG18 was found to reverse the effect of miR-324-5p by upregulating CDK16 expression in melanoma cell proliferation, apoptosis, migration and invasion in vitro. Besides, we found that HCG18 was closely correlated with thickness, TNM stage and metastasis. Yes Functional experiments discovered that HCG18 knockdown restrained cell proliferation, migration and invasion, while promoted cell apoptosis in melanoma cells. 35273726 HCG18 LncRNA Homo sapiens Prostatic Neoplasms PC cells Interaction(miR-370-3p/DDX3X Axis) RNA Pull-Down//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay According to the results, HCG18 was significantly up-regulated in PC cells and it facilitated cell proliferation, migration, and invasion in PC. Furthermore, a series of mechanism experiments were carried out to verify the relationship among HCG18, miR-370-3p, and DEAD-box helicase 3 X-linked(DDX3X) in PC cells. In summary, our study showed that lncRNA HCG18 accelerated cell proliferation, invasion, and migration of PC via up-regulating DDX3X through sponging miR-370-3p, providing a novel finding about PC-related regulatory mechanism. Yes According to the results, HCG18 was significantly up-regulated in PC cells and it facilitated cell proliferation, migration, and invasion in PC 34708395 HCP5 LncRNA Homo sapiens Rhinitis, Allergic PBMCs, CD4+ T cells, Tregs, and nasal tissues of AR patients Interaction(miR-16/ATXN2L axis) Western Blot//Transection//qRT-PCR//Flow Cytometry//CCK8//Luciferase Report Assay//ELISA lncRNA HCP5 expression dramatically downregulated in PBMCs, CD4+ T cells, Tregs, and nasal tissues of AR patients, as well as in IL-13-treated NECs.HCP5 promoted Tregs differentiation and proliferation via targeting miR-16/ATXN2L axis. Additionally, HCP5 inhibited IL-13-induced GM-CSF, eotaxin, and MUC5AC production in NECs. HCP5 sponged miR-16 and negatively regulated its expression, and miR-16 targeted ATXN2L and inhibition of miR-16 suppressed IL-13-induced GM-CSF, eotaxin, and MUC5AC expression. HCP5/miR-16/ATXN2L axis mediated Tregs proliferation and functions in AR. Besides, the regulation of IL-13-induced dysfunction of NECs by lncRNA HCP5 depended on miR-16/ATXN2L in the inflammatory response of AR. Yes HCP5 promoted Tregs differentiation and proliferation via targeting miR-16/ATXN2L axis. 35122570 HCG18 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissue and cell lines Regulation[ miR-140/CCND1 and Hedgehog signaling pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay We found that HCG18 expression was upregulated in both NPC specimens and cell lines.Mechanistically, HCG18 may directly bind to miR-140 and effectively act as a ceRNA for miR-140 to increase the expression of cyclin D1 (CCND1). In addition, HCG18 may contribute to NPC progression via modulating Wnt/β-catenin signaling and Hedgehog pathway. Higher levels of HCG18 were associated with positive lymph node metastasis and poor prognosis of NPC patients. Importantly, the multivariate analysis confirmed that HCG18 was an independent risk factor for outcome. Yes Functionally, the downregulation of HCG18 exhibited tumor-suppressive effects via the inhibition of cell proliferation and metastasis. 31841193 HCP5 LncRNA Homo sapiens stomach carcinoma GC tissues interaction[miR-27b-3p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay We found that HCP5 was overexpressed in GC tissues. The effect of silencing HCP5 on repressing GC cells viability and metastasis by regulating EMT-associated markers can be partially reversed by miR-27b-3p inhibitor. Patients with higher expression of HCP5 had larger tumors, were more likely to have lymph node metastasis, and had higher TNM stage. Yes HCP5 was overexpressed in GC cells, but this was reversed by miR-27b-3p. Silencing HCP5 inhibited GC cell viability and metastasis by downregulating Vimentin and N-cadherin and up-regulating E-cadherin, but this effect was partially reversed by miR-27b-3p inhibitor. 32357145 HCP5 LncRNA Homo sapiens Neuroblastoma NB tissues and cells regulation[miR-186-5p/MAP3K2 signal axis] qRT-PCR We found that the HCP5 expression was up-regulated in NB tissues and cells.This study showed that lncRNA HCP5, as ceRNA, regulated MAP3K2 to promote NB progression through competitive binding of miR-186-5p. Yes Down regulation of the HCP5 expression inhibited the proliferation of NB cells and the growth of subcutaneous transplanted tumor in nude mice. 33189302 HCP5 LncRNA Homo sapiens Skin Neoplasms CSCC cells Regulation(STAT3/VEGFR2 pathway) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Tunel//CCK8//qRT-PCR//Flow Cytometry//Microarray//IHC//Transwell Assay In conclusion, HCP5 may competitively bind to miR‑138‑5p to regulate EZH2 in CSCC cells, promoting autophagy and reducing apoptosis through the STAT3/VEGFR2 pathway. Yes In conclusion, HCP5 may competitively bind to miR?138?5p to regulate EZH2 in CSCC cells, promoting autophagy and reducing apoptosis through the STAT3/VEGFR2 pathway. 34195851 HCP5 LncRNA Homo sapiens skin melanoma SKCM tissue Interaction[sponging miR-12] Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Invasion Assay//Transwell Assay HCP5 level was decreased in SKCM tissue specimens compared to noncancerous counterparts.HCP5 overexpression decreased SKCM cell malignancy in vitro by upregulating RARRES3, possibly via sponging miR-1286. Low expression of HCP5 was associated with SKCM patients' poor overall survival and disease progression. Yes HCP5 overexpression significantly reduced the malignancy of primary SKCM cells in vitro. 31496735 HCG22 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Interaction(miR-650) qRT-PCR Compared with that in adjacent tissues, the expression of HCG22 significantly decreased in OSCC tissues (P<0.05). Compared with that in HOK cells, the expression of HCG22 was significantly lower in SCC-25, HN13, HSC-3, and CAL-27 cells (P<0.05). miR-650 mimics could reduce the luciferase activity of HCG22 wild-type plasmid cells (P<0.05), and the expression of miR-650 in SCC-25 and HSC-3 cells decreased after upregulation of HCG22 expression (P<0.05). Moreover, the prognostic survival of patients in the low-HCG22 expression group was significantly lower than that in the high-expression group (P<0.05). Yes Upregulation of HCG22 expression could inhibit the proliferation, migration, invasion, and apoptosis of SCC-25 and HSC-3 cells, upregulatethe expression of E-cadherin, and downregulate the expression of N-cadherin and vimentin (P<0.05). 34859625 HCG22 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells Regulation(Akt, mTOR, and Wnt/β-catenin pathways) BrdU//qRT-PCR//Transwell Assay We found that HCG22 was weakly expressed in OSCC cells. . In conclusion, HCG22 exerted anti-tumor property in OSCC by inhibiting the Akt, mTOR, and Wnt/β-catenin pathways. Yes HCG22 overexpression inhibited cell proliferation and invasion and induced apoptosis in OSCC cells. The levels of PCNA, Vimentin, and Bcl-2 were decreased and E-cadherin and Bax expression was elevated in OSCC cells after HCG22 overexpression. 33649984 HCG22 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cell lines Interaction(miR-425-5p ) CCK8//qRT-PCR//Western Blot The results revealed that lncRNA HCG22 was expressed at low levels, while miR-425-5p was highly expressed in OSCC cell lines, based on bioinformatics analysis. Moreover, lncRNA HCG22 and miR-425-5p were found to have a direct targeted association, and lncRNA HCG22 inhibited cell proliferation, invasion and migration by targeting miR-425-5p. Yes The overexpression of lncRNA HCG22 inhibited the proliferation, invasion and migration of OSCC cells. 35222723 HCG18 LncRNA Homo sapiens Stomach Neoplasms GC tissues interaction[binding to miR-197-3p] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay//ChIP It was found that HCG18 was upregulated in GC samples, and the knockdown of HCG18 inhibited proliferative and migratory abilities in GC. HCG18 is upregulated in GC samples by E2F1 induction, which stimulates proliferative and migratory abilities in GC by binding to miR-197-3p. Yes It was found that HCG18 was upregulated in GC samples, and the knockdown of HCG18 inhibited proliferative and migratory abilities in GC. 33090399 HCG18 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-152-3p,DNAJB12 ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay It was found that HCG18 was upregulated in GC tissues and cell lines, Our results demonstrated that HNF1A-induced HCG18 overexpression promoted GC progression by competitively binding with miR-152-3p and upregulating DNAJB12 expression. Patients with high HCG18 expression had a shorter overall survival time compared with those with low HCG18 expression. Yes It was found that HCG18 was upregulated in GC tissues and cell lines, and knockdown of HCG18 inhibited the proliferation, migration, and invasion of GC cells. 32801777 HCG18 LncRNA Homo sapiens Stomach Neoplasms GC specimens regulation[miR-141-3p ] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay HCG18 was aberrantly up-regulated in GC tissues, and it indirectly regulated the activity of Hippo signaling through counteracting miR-141-3p expression. Yes Down-regulation of HCG18 inhibited viability, migration, and invasion of GC cells, while miR-141-3p transfection led to opposite effect. 32725768 HCG18 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-146a-5p/TRAF6) IHC//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay HCG18 expression was increased in GC. Furthermore, HCG18 overexpression inhibited miR-146a-5p and upregulated TRAF6 and p65 expression. Altogether, HCG18 promotes GC progression via the miR-146a-5p/TRAF6 axis and could be a GC treatment target. Yes HCG18 overexpression significantly increased GC cell proliferation, invasion, and migration. Finally, miR-146a-5p/TRAF6 was found to be involved in the role of HCG18 in GC progression in vivo. 35240920 HCG18 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-370-3p/EGFR axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay HCG18 expression was up-regulated in GC tissues, and its high expression was closely associated with increased tumour size, advanced TNM stage, poor differentiation of tumour tissues and unfavourable prognosis of patients with GC. Furthermore, HCG18 served as a miRNA sponge to repress miR-370-3p and indirectly up-regulated EGFR expression in GC cells. HCG18 expression was up-regulated in GC tissues, and its high expression was closely associated with increased tumour size, advanced TNM stage, poor differentiation of tumour tissues and unfavourable prognosis of patients with GC. Yes Additionally, HCG18 overexpression promoted the proliferation, migration and invasion of GC cells, and its knockdown suppressed the malignant phenotypes of GC cells. 34618022 HCG18 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell Interaction(miR-103a-3p/UBE2O/mTORC1/HIF-1α-Positive Feedback Loop) Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//Invasion Assay In this study, we demonstrated that HCG18 is significantly upregulated in BC tissues and cells and that BC patients with high HCG18 expression tend to have poor prognosis. In terms of mechanism, we found that HCG18 positively regulated the expression of BC-related ubiquitin-conjugating enzyme E2O (UBE2O) by sponging miR-103a-3p, and our previous research verified that UBE2O could promote the malignant phenotypes of BC cells through the UBE2O/AMPKα2/mTORC1 axis. In this study, we demonstrated that HCG18 is significantly upregulated in BC tissues and cells and that BC patients with high HCG18 expression tend to have poor prognosis. Yes In vitro assays indicated that HCG18 promotes BC cell proliferation and invasion and endows BC cells with cancer stemness properties. In vivo assays revealed that reducing HCG18 expression in the BC cell line MDA-MB-231 markedly decreased tumor growth and lung metastasis in xenograft mouse models. 34976998 HCG18 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cell lines regulation[HCG18/miR-1271/ MTDH/Wnt/β-catenin signalling] qRT-PCR Herein, we found that HCG18 expression was significantly upregulated in colorectal cancer tissues and cell lines.Overall, the results of our study demonstrate that HCG18 exerts a potential oncogenic function in colorectal cancer by enhancing MTDH/Wnt/β-catenin signalling via sponging of miR-1271, highlighting the importance of HCG18/miR-1271/ MTDH/Wnt/β-catenin signalling in the progression of colorectal cancer. Yes Knockdown of HCG18 significantly inhibited the growth and invasion of colorectal cancer cells, while its overexpression had the opposite effect. 31854468 HCG18 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-214-3p/CENPM axis] Flow Cytometry//qRT-PCR//Wound Healing Assay//Colony Formation Assay The results showed that HCG18 was highly expressed in HCC tissues. Therefore, those results suggested HCG18 functioned as an oncogene to promote the proliferation and migration of HCC cells via miR-214-3p/CENPM axis. Yes HCG18 silencing inhibited the proliferation and migration while induced the apoptosis of HCC cells. 32663252 HCG18 LncRNA Homo sapiens Ovarian Neoplasms EOC tissues Interaction(miR-29a/b/TRAF4/TRAF5/NF-κB pathway) qRT-PCR//MTT//IHC Abnormal expression of HCG18 and miR-29a/b was observed in EOC tissues.miR-29a/b mimics and TRAF4/5 knockdown exhibited effects similar to HCG18 knockdown. Further experiments suggested that HCG18 directly targets miR-29a/b and upregulates TRAF4/5 expression, which are inhibited by targeting miR-29a/b. Moreover, overexpression of TRAF4/5 antagonized the inhibitory effect of HCG18 knockdown, suggesting that they are involved in HCG18-mediated oncogenic effects. Yes Knockdown of HCG18 using shRNA inhibited proliferation, migration, EMT and the proinflammatory pathway in EOC cells. Silencing HCG18 reduced tumour size and levels of Ki67 and TRAF4/5 while increasing miR-29a/b levels in vivo. 34983361 HCG18 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC patient tissues and cell lines Interaction( cyclin D1) qRT-PCR//RIP//Western Blot We observed that HCG18 was upregulated in HNSCC patient tissues and cell lines. We also found that HCG18 directly binds to the functional protein cyclin D1. Upregulated cyclin D1 reversed the inhibitory effects of HCG18 in HNSCC cell lines and activated the WNT pathway-related proteins (AXIN2, survivin, c-Myc, and β-catenin) simultaneously. Knockdown of cyclin D1 could accelerate the inhibitory effects of HCG18 and decrease the expression of AXIN2, survivin, c-Myc, and β-catenin. This indicated that lncRNA HCG18 might be involved in the tumorigenesis of HNSCC via the cyclin D1-WNT pathway. Yes Furthermore, silencing of HCG18 significantly inhibited proliferation, migration, and invasion of HNSCC cells, whereas the opposite effects were detected in the HCG18-overexpressed group. 35389764 HCG18 LncRNA Homo sapiens Osteosarcoma OS tumor tissues and cell lines Interaction(miR-34a/RUNX2 Pathway) RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay HCG18 and RUNX2 were notably enhanced, whereas miR-34a was decreased in OS tumor tissues and cell lines. Furthermore, HCG18 directly bound to miR-34a, and miR-34a was confirm to be a negative regulator of RUNX2. Interestingly, the anti-tumor effects of HCG18 silencing were attenuated by miR-34a inhibitor and RUNX2 overexpression. Yes Functional experiments uncovered that HCG18 silencing significantly inhibited the capabilities of proliferation, migration, and invasion, while overexpression of HCG18 play the opposite roles. 36401685 HHIP-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[HHIP ] qRT-PCR The expression levels of HHIP-AS1 were significantly decreased in HCC tissues.Taken together, our findings demonstrate that HHIP-AS1 represses HCC progression by promoting HHIP expression, and indicate that the use of HHIP-AS1 may offer a promising treatment for HCC patients. Downregulation of HHIP-AS1 expression correlated with larger tumor size, metastasis, and advanced TNM stage, and also predicted worse overall survival rate of HCC patients. Yes Through performing overexpression and knockdown experiments, the biological function of HHIP-AS1 was identified to suppress HCC cell proliferation, migration and invasion, while promote apoptosis. 31604528 HHIP‑AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Interaction(miR‑153‑3p/PCDHGA9 axis) CCK8//qRT-PCR//Transwell Assay The results showed that the expression of HHIP?AS1 in lung cancer tissues was significantly lower than that in normal tissues (P<0.001). In conclusion, HHIP‑AS1 inhibits the EMT and stemness of lung cancer cells by regulating the miR‑153‑3p/PCDHGA9 axis. Yes HHIP‑AS1 overexpression inhibited the proliferation, invasion and clonal formation of the A549 and NCI‑H1299 cells. 34643245 HIF1A-AS2 LncRNA Homo sapiens Small Cell Lung Carcinoma SCLC cells Regulation qRT-PCR//Transfection//Cell Apoptosis Assay//Western Blot The levels of HIF-1α and Beclin-1 were decreased in both cell lines by knockdown of HIF1A-AS2. MRP1 expression was decrease in H69AR cells. In addition, CoCl2-induced hypoxic environment decreased in doxorubicin sensitivity of H69 cells, and knockdown of HIF1A-AS2 reversed this effect of hypoxia. Knockdown of HIF1A-AS2 increased drug sensitivity of SCLC cells in relation to autophagy. Yes Knockdown of HIF1A-AS2 increased doxorubicin sensitivity of SCLC cells and decreased autophagy. Knockdown of HIF1A-AS2 has also affected the expression of several genes that will increase drug sensitivity and inhibit autophagy in both cell lines. 34378101 HOTAIR LncRNA Homo sapiens Skin Neoplasms cell lines Interaction[sponging miR-326] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay HOTAIR expression in CSCC cell lines exhibited an obvious elevation. Furthermore, HOTAIR competitively bound to miR-326, so as to positively modulate miR-326 expression. Yes Cell function analysis revealed that HOTAIR overexpression remarkably facilitated CSCC cell migration, proliferation and EMT process, which were impeded by down-regulation of HOTAIR. 31649487 HOTAIR LncRNA Homo sapiens Pre-Eclampsia PE placenta tissues interaction[targeting miR-106] RIP//qRT-PCR//EdU Staining//ChIP HOTAIR was up-regulated in PE placenta tissues, which repressed the proliferation, migration and invasion of trophoblast cells. High level of HOTAIR repressed the proliferation, migration and invasion of trophoblast cells through targeting miR-106 in an EZH2-dependent manner, which may provide new insights into the roles of HOTAIR and miR-106a as potential regulators in PE. Yes HOTAIR was up-regulated in PE placenta tissues, which repressed the proliferation, migration and invasion of trophoblast cells. 32320706 HOTAIR LncRNA Homo sapiens Psoriasis HaCaT cells Interaction( lncRNA-HOTAIR/miR-126 axis) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay IL-22 induced cell proliferation and suppressed apoptosis. However, HOTAIR-plasmid inhibited cell viability and induced apoptosis in IL-22-stimulated HaCaT cells. In addition, the western blotting results indicated that HOTAIR-plasmid increased cleaved caspase-3 expression and the cleaved caspase-3/caspase-3 ratio, whereas the HOTAIR-plasmid-mediated effects were reversed by miR-126 mimic. Collectively, the results of the present study demonstrated that the lncRNA-HOTAIR/miR-126 axis may be implicated in the regulation of psoriasis progression and may serve as a potential therapeutic target for psoriasis. Yes IL-22 induced cell proliferation and suppressed apoptosis. However, HOTAIR-plasmid inhibited cell viability and induced apoptosis in IL-22-stimulated HaCaT cells. 33747185 HOTAIR LncRNA Homo sapiens Diabetic Retinopathy endothelial cells Expression [highly expressed] In Vivo Experiment//FISH//Tube Formation Assay Hyperglycemia significantly augmented HOTAIR expression in HRECs and promoted angiogenesis, oxidative damage, and mitochondrial aberrations. Similarly, vitreous humor and serum from proliferative DR patients and retinas from diabetic animals demonstrated increased HOTAIR expression compared to non-diabetic controls. Yes HOTAIR knockdown protected against glucose-induced increases of angiogenic and diabetes-associated molecules in the retina. Mechanistically, we showed that HOTAIR exerts its capabilities by preventing oxidative stress and modulating epigenetic pathways involving histone methylation, histone acetylation, DNA methylation, and transcription factors. 33724292 HOTAIR LncRNA Homo sapiens Sarcoma, Synovial SS tissues Interaction(microRNA-126/SDF-1) cell invasion assay//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//IF HOTAIR was expressed at high levels in SS tissues.. In contrast, miR-126 was expressed at low levels in SS tissues, and was negatively correlated with HOTAIR expression. Furthermore, HOTAIR knockdown increased miR-126 expression level and decreased the expression level of stromal cell-derived factor-1 (SDF-1) at the protein level. On the other hand, while miR-126-mimic decreased the protein expression level of SDF-1, miR-126-inhibitor increased its expression level in SW982 cells. Yes HOTAIR knockdown in SW982 cells inhibited cellular proliferation in vitro, but also significantly increased the ratio of cells in the G1/G0 phase of the cell cycle, and decreased the ratio of cells in the G2/S phase.HOTAIR knockdown inhibited the invasion and migration of the SW982 cells, as observed in the Transwell and wound healing assays. 33868482 HOTAIR LncRNA Homo sapiens Uterine Cervical Neoplasms HPV16-positive cervical cancer cells Interaction(miR-214-3p/Wnt/β-catenin signal pathway) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Colony Formation Assay//RIP//MTT//RNA-seq//ChIP-seq//IHC Our results showed that expression of HOTAIR was up-regulated, while that of miR-214-3p was down-regulated in HPV16-positive cervical cancer cells. HOTAIR could act as a ceRNA through binding to miR-214-3p, promote cell proliferation and inhibit the apoptosis of HPV16 positive cervical cancer. HOTAIR/miR-214-3p/Wnt/β-catenin signal pathway might played important regulated roles in HPV16 positive cervical cancer. Yes HOTAIR knockdown could significantly inhibited cell proliferate ability and promote cellular apoptosis, whereas the inhibition of miR-214-3p expression partially reversed such results. 34320988 Hotair LncRNA Mus musculus Breast Neoplasms breast cancer cells Regulation qRT-PCR//RNA-seq//Invasion Assay We show that sustained high levels of HOTAIR over time increased breast metastatic capacity and invasiveness in breast cancer cells, promoting migration and subsequent metastasis to the lung. Yes We show that sustained high levels of HOTAIR over time increased breast metastatic capacity and invasiveness in breast cancer cells, promoting migration and subsequent metastasis to the lung. 36579891 Hotair LncRNA Mus musculus Osteoarthritis articular cartilage tissues regulation[miR-20b/PTEN axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Results found that HOTAIR was significantly up-regulated in articular cartilage tissues of OA mice and IL-1β-induced chondrocytes, accompanied by down-regulation of miR-20b and increased expression of the phosphatase and tensin homolog (PTEN). HOTAIR can participate in OA by promoting chondrocyte apoptosis and ECM degradation, which may be related to its targeted regulation of miR-20b/PTEN axis. Yes HOTAIR silencing improved cartilage tissue damage in OA mice, and promoted the expression of collagen II and aggrecan in cartilage tissue, while inhibited the expression of matrix metalloproteinases (MMP)-13 and ADAMTS-5. Overexpression of HOTAIR inhibited the proliferation of IL-1β-induced chondrocytes and promoted apoptosis and extracellular matrix (ECM) degradation, whereas the effect of HOTAIR knockdown was reversed. 32315726 Hotair LncRNA Mus musculus Parkinson Disease brain tissue Interaction[regulating miR-126-5p and RAB3IP] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay Real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting indicated that HOTAIR and RAB3IP increased while miR-126-5p decreased in PD cells and PD mice. Yes Additionally, the CCK-8 assay and flow cytometric analysis indicated that the knockdown of HOTAIR and RAB3IP and the overexpression of miR-126-5p significantly increased cell proliferation and reduced apoptosis in PD cells. 30738012 Hotair LncRNA Mus musculus Parkinson Disease brain tissues,cell lines regulation[miR-326/ELAVL1 Axis] qRT-PCR//Luciferase Report Assay//RIP LncRNA HOTAIR was upregulated in PD mice and MPP induced SH-SY5Y cells.Collectively, HOTAIR silencing significantly inhibits neuronal damage through repressing NLRP3 mediated pyroptosis activation via regulation of miR-326/ELAVL1 axis in PD, which may contribute to a better understanding of PD pathogenesis and provide new treatment strategies for this disease. Yes Additionally, knockdown of HOTAIR notably attenuated the symptom of PD in vivo. 32968928 Hotair LncRNA Mus musculus Sepsis Monocytes Interaction[as a sponge of miR-211 to induce IL-6R expression] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay The expression of IFN-γ, IL-6, IL-17, TNF-α, IL-1β, IL-6R and HOTAIR was significantly upregulated in the septic mice, whereas miR-211 expression was downregulated.HOTAIR may promote the progression of sepsis by indirectly regulating the expression of IL-6R via miR-211. Yes HOTAIR overexpression and miR-211 knockdown significantly inhibited cellular proliferation and promoted monocyte apoptosis, whereas the overexpression of miR-211 exhibited the opposite effects in monocytes. 31656541 Hotair LncRNA Mus musculus Myocardial Reperfusion myocardial tissues,cell line interaction[binding SRSF1 with microRNA-126] qRT-PCR//ELISA//Luciferase Report Assay LDH and CK-MB were significantly released in mice with myocardial IR. HOTAIR was upregulated, while microRNA-126 was downregulated in IR mice and H2O2-induced H9c2 cells. HOTAIR aggravates myocardial IR by competitively binding SRSF1 with microRNA-126. Yes Overexpression of HOTAIR stimulated proliferative ability, LDH release, and Caspase-3 activity in H2O2-induced H9c2 cells. 32964995 HOMER3-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(HOMER3/Wnt/β-catenin axis) qRT-PCR//Western Blot//IHC//IF Here, we identified a lncRNA, HOMER3-AS1, which is over-expressed in HCC and correlated with poor survival of HCC patients. Mechanism investigations revealed that HOMER3-AS1 activated Wnt/β-catenin signaling via upregulating HOMER3. Functional rescue experiments revealed that HOMER3/Wnt/β-catenin axis mediated the roles of HOMER3-AS1 in promoting HCC cellular malignant phenotypes. Here, we identified a lncRNA, HOMER3-AS1, which is over-expressed in HCC and correlated with poor survival of HCC patients. Yes HOMER3-AS1 promoted HCC cellular proliferation, migration, and invasion, and reduced HCC cellular apoptosis. Furthermore, HOMER3-AS1 promoted macrophages recruitment and M2-like polarization. In vivo, HOMER3-AS1 significantly facilitated HCC progression. 34815380 HOMER1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues regulation[miR-1322/CXCL6 axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Notably, circ-HOMER1 was upregulated in both HCC cells and tissues.Furthermore, we found that circ-HOMER1 promoted HCC cell growth and aggressiveness by miR-1322/CXCL6 axis. This aberrant expression pattern was closely correlated with larger tumor size, higher tumor-node-metastasis stage, and poorer prognosis for the patients with HCC. Yes Moreover, silenced circ-HOMER1 inhibited cell proliferation, migration, and invasion concomitant with the promotion of apoptosis in HCC cells, and vice versa. 32037619 HOMER1 LncRNA Homo sapiens Alzheimer Disease AD female Regulation qRT-PCR//Western Blot First, we showed downregulation of HOMER1B/C and HOMER1A mRNA and hsa_circ_0006916 and hsa_circ_0073127 levels in AD female cases compared to controls by RT-qPCR.A positive correlation was observed between HOMER1B/C, HOMER1A mRNA, and hsa_circ_0073128 with HOMER1B/C protein only in females. Yes SNHG5 silencing or miR-299 overexpression suppressed the proliferation of BC cell, arrested the cell cycle in the G1 cell phase, and decreased the glucose consumption and lactate production of BC cell. 34502114 HNSCAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCs tissue and cells Regulation(KRT80) Western Blot//Wound Healing Assay//CCK8//RNA-seq//Colony Formation Assay HNSC-associated transcript 1 (HNSCAT1, previously recognized as linc01269), was downregulated in tumor samples and advanced tumor stages and was also associated with favorable outcomes in HNSC. More importantly, through high-throughput transcriptome analysis (RNA-seq, in NODE database, OEZ007550), we identified KRT80, a tumor suppressor in HNSC, as the target of HNSCAT1. KRT80 expression was modulated by lncRNA HNSCAT1 and presented a positive correlation in tumor samples (R = 0.52, p < 0.001). Yes Overexpression of HNSCAT1 triggered treatment efficacy in HNSCs both in vivo and in vitro. 35965679 HNRNPU LncRNA Homo sapiens Uterine Cervical Neoplasms CC patients and cell lines Interaction(MicroRNA 205-5p/AXIN2 Axis and Wnt/β-Catenin Signaling Pathway) RNA Pull-Down//Western Blot//Transfection//Colony Formation Assay//Flow Cytometry//CCK8//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC As revealed by Kaplan-Meier curve, CC cases showing low HNRNPU-AS1, high miR-205-5p, and low AXIN2 levels had the poorest prognosis. Yes AXIN2 reversed the CC cell proliferation-promoting, apoptosis-inhibiting, and Wnt/β-catenin signaling-activating behavior mediated by miR-205-5p or HNRNPU-AS1 knockout. 34309414 HNF1A-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tumors and cell lines regulation[miRNA-20a-5p/TRIM32 Axis] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay Expression of HNF1A-AS1 and TRIM32 was upregulated and miR-20a-5p was downregulated in breast cancer tumors and cell lines. Knockdown of HNF1A-AS1 suppressed breast carcinogenesis presumably through targeting miR-20a-5p/TRIM32 axis, suggesting that HNF1A-AS1 might be a promising therapy target for breast cancer. Yes Deletion of HNF1A-AS1 induced cell apoptosis rate, but suppressed cell proliferation, EMT, migration, and invasion in MDA-MB-231 and MCF-7 cells. 32319789 HOTAIR LncRNA Homo sapiens Skin Neoplasms CSCC, CSCC cell lines A431 or SCC13, A431- or SCC13-derived CSCC stem cells Interaction(Sp1/miR-199a ) In Vivo Experiment//ChIP//Western Blot//Transfection//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//IF By measuring its expression using RT-qPCR in CSCC vs. normal tissues, as well as in CSCC cell lines A431 or SCC13, A431- or SCC13-derived CSCC stem cells (CSCSCs), and normal skin fibroblasts (HSFs), we detected higher expression of HOTAIR in CSCC than in normal tissues, in recurrent than in non-recurrent CSCC tissues, in CSCCs and CSCSCs than in HSFs, and particularly, in CSCSCs than in CSCCs. Mechanistically, HOTAIR directly interacted with and up-regulated Sp1. Sp1 then induced DNMT1-mediated promoter methylation and direct transcriptional repression of miR-199a-5p. Targeting Sp1 or DNMT1 further boosted the in vivo anti-tumor and anti-metastasis activities of targeting HOTAIR. Kaplan-Meier analysis suggested that higher expression of HOTAIR was positively correlated with worse overall survival of CSCC patients. Yes Functional assays on colony formation, EdU incorporation, sphere formation, western blot on stem-cell biomarkers, and in vivo models showed that HOTAIR was essential in maintaining multiple stem cell phenotypes of CSCSCs in vitro and in vivo xenograft growth as well as metastasis. 34697449 HOTAIR LncRNA Homo sapiens Non-alcoholic Fatty Liver Disease NAFLD tissues Interaction(miR-130b-3p/ROCK1 axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Oil Red O Staining The level of HOTAIR was upregulated in NAFLD. Meanwhile, HOTAIR bound with miR-130b-3p, and ROCK1 was identified to be the direct target of miR-130b-3p. Moreover, miR-130b-3p mimics-caused lipid accumulation decrease was reversed by pcDNA3.1-ROCK1. Yes Downregulation of HOTAIR reversed lipid accumulation in FFA-treated HepG2 cells and primary hepatocytes. 34774989 HIF1A-AS2 LncRNA Homo sapiens Carcinoma, Renal Cell kidney carcinoma tissues Interaction(miR-30a-5p/SOX4 axis) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//migration assay//Luciferase Report Assay//Cell Proliferation Assay//EdU Staining HIF1A-AS2 was upregulated in kidney carcinoma tissues when compared with para-carcinoma tissues (P < 0.05).The HIF1A-AS2-miR-30a-5p-SOX4 axis was associated with the malignant progression and development of renal carcinoma. In addition, tumor size, tumor node mestastasis stage and differentiation were identified as being closely associated with HIF1A-AS2 expression (P < 0.05). Yes Knockdown or overexpression of HIF1A-AS2 either restrained or promoted the malignant phenotype and WNT/β-catenin signaling in renal carcinoma cells (P < 0.05). MiR-30a-5p was downregulated in renal cancers and partially reversed HIF1A-AS2 functions in malignant renal tumor cells. HIF1A-AS2 acted as a microRNA sponge that actively regulated the relative expression of SOX4 in sponging miR-30a-5p and subsequently increased the malignant phenotypes of renal carcinomas. HIF1A-AS2 showed a carcinogenic effect and miR-30a-5p acted as an antagonist of the anti-oncogene effects in the pathogenesis of renal carcinomas. 33710813 HOTAIR LncRNA Homo sapiens Pulmonary Disease, Chronic Obstructive COPD patient lungs and CSE-induced HPVEC Interaction(DNMT1) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Microarray//Cell Proliferation Assay The expression levels of the HOTAIR were up-regulated in COPD patient lungs and CSE-induced HPVEC. HPVEC apoptosis with down-regulated Bcl-2 expression, increased promoter methylation, DNMT1, Bax and Cleaved-caspase 3 expression was found in emphysema mouse model and CSE-induced HPVEC. DNMT1 was a target of HOTAIR and had a positive correlation with HOTAIR. Yes Knockdown HOTAIR can attenuate cell apoptosis and emphysema via DNMT1 mediated hypermethylation of Bcl-2 promoter in mice. In vitro, HOTAIR can aggravate the apoptosis of CSE-exposed HPVEC. 36527094 HOTAIR LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues and cell lines Interaction( miR-34a /JAK2/STAT3 pathway) CCK8//qRT-PCR//RNA Pull-Down//Luciferase Report Assay HOTAIR was upregulated in CSCs following PDAC enrichment of PDAC.Conversely, miR-34a was downregulated and appeared to be a direct target of HOTAIR. Furthermore, HOTAIR activated the JAK2/STAT3 pathway through miR-34a, thereby promoting CSCs-like properties, invasion and migration of PDAC cells. Yes Moreover, knocking down HOTAIR or overexpressing miR-34a significantly inhibited CSCs-like properties, invasion and migration of PDAC cells. In vivo experiments indicated that knocking down HOTAIR could inhibit the tumorigenicity of CFPAC-1 cells. 33737813 HOTAIR LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Interaction[MAPK1] Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The results showed that the expression of lncRNA HOTAIR was significantly (p < 0.01) upregulated (up to 4.1-fold) in cervical cancer cell lines. Yes Silencing of lncRNA HOTAIR expression resulted in inhibition of the proliferation of the DoTc2 cervical cancer cells via induction of apoptotic cell death. HOTAIR silencing also resulted in decrease of the migration and the invasive properties of the cervical cancer cells. 32864005 HOTAIR LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Expression [highly expressed] In Vivo Experiment//IHC//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//MTT//migration assay//H&E Staining//cell invasion assay//Colony Formation Assay//ChIP LncRNA HOTAIR and EZH2 were highly expressed in NPC, and E-cadherin was lowly expressed. HOTAIR recruited histone methylase EZH2 to mediate trimethylation of H3K27 and regulated E-cadherin expression. Yes Down-regulation of HOTAIR or EZH2 inhibited NPC cell progression and tumor growth. 33965547 HOTAIR LncRNA Homo sapiens Glioblastoma GBM cell lines Regulation(upregulating H3K4me2 and downregulating H3K27me3) In Vivo Experiment//Western Blot//H&E Staining//Flow Cytometry//qRT-PCR//IF//Microarray//Cell Proliferation Assay//IHC//ChIP we found that the combination of AQB and GSK-LSD1 showed a powerful effect of inhibiting cell cycle processes by targeting CDKN1A, whereas apoptosis promoting effects of combination therapy were mediated by BBC3 in vitro. ChIP assays revealed that GSK-LSD1 and AQB regulate P21 and PUMA, respectively via upregulating H3K4me2 and downregulating H3K27me3. Yes Microarray analysis showed that AQB and GSK-LSD1 regulate cell cycle processes and induces apoptosis in GBM cell lines. 34246782 HOTAIR LncRNA Homo sapiens Glioblastoma glioma tissues Interaction(miR-301a-3p/FOSL1) Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay In this study, HOTAIR expression was found to be positively regulated by TRPM7, significantly upregulated in glioma tissues, and is a poor prognosis factor for glioma patients. Mechanistically, HOTAIR directly interacted with miR-301a-3p, and downregulation of miR-301a-3p efficiently reversed FOSL1 suppression induced by siRNA HOTAIR, which implied that HOTAIR positively regulated FOSL1 level through sponging miR-301a-3p and played an oncogenic role in glioma progression. In contrast to HOTAIR's role, miR-301a-3p alone served as a tumor suppressor to decrease glioma cell viability and migration/invasion. Yes Moreover, reduced HOTAIR expression impeded the proliferation and invasion of glioma cells. 35292358 HOTAIR LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues and cells Interaction[sponging miR-17-5p] qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay HOTAIR was significantly upregulated, while miR-17-5p was downregulated in thyroid cancer tissues and cells.MiR-17-5p was a target of HOTAIR and counter-regulated by HOTAIR. Introduction of miR-17-5p also inhibited the cell viability, migration and invasion in TPC-1 and FTC-133 cells. Moreover, introduction of miR-17-5p reversed knockdown of HOTAIR-mediated the suppression effects on the cell viability, migration and invasion in thyroid cancer cells. Yes Silencing HOTAIR significantly inhibited the cell viability, migration and invasion of TPC-1 and FTC-133 cells. Additionally, knockdown of HOTAIR inhibited thyroid cancer tumorigenesis in mice. 31607138 HOTAIR LncRNA Homo sapiens Thyroid Cancer, Papillary cell lines Regulation(DLX1) Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//Cell Proliferation Assay//IHC//ChIP We observed HOTAIR was highly expressed in MDA-T32 cells but presents significantly decreased levels in MDA-T41 and K1 cells. To explore novel HOTAIR downstream mechanisms, we analyzed TCGA transcriptome in PTC tissues and found DLX1 negatively correlated to HOTAIR, and its lower expression associated with reduced progression free survival. We further validated DLX1 gene was epigenetically suppressed by HOTAIR via performing chromatin immunoprecipitation. Moreover, IHC staining shows a significantly stepwise decrease of DLX1 protein from normal thyroid tissues to stage III PTC tissues. Yes HOTAIR knockdown in MDA-T32 cells significantly suppressed proliferation, colony formation, migration with cell cycle retardation at G1 phase. On the contrary, HOTAIR overexpression in MDA-T41 cells dramatically enhanced proliferation, colony formation, migration with cell cycle driven toward S and G2/M phases. 36494673 HOTAIR LncRNA Homo sapiens Medulloblastoma medulloblastoma tissues and cell lines regulation[miR-1/miR-206-YY1 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, we found that HOTAIR and YY1 were up-regulated in medulloblastoma tissues and cell lines, and HOTAIR increased YY1 expression. These data indicate that HOTAIR promotes medulloblastoma progression via acting as a competing endogenous RNA (ceRNA) to regulate YY1 expression through binding to miR-1 and miR-206. Yes The functional experiments showed that HOTAIR knockdown suppressed medulloblastoma cell proliferation, tumor growth, migration and invasion, and promoted cell apoptosis via the modulation of the miR-1/miR-206-YY1 axis, as well as epithelial to mesenchymal transition (EMT). 31986414 HOTAIR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissue Expression(highly expressed) CCK8//qRT-PCR//Tunel//Cell Apoptosis Assay qRT-PCR results showed that the expression of LncRNA Hotair in tumor tissue and serum of patients with non-small-cell lung cancer was significantly upregulated. These results show that the expression level of LncRNA Hotair of NSCLC cell lines can promote the invasion and migration of NSCLC, and its expression has a significant correlation with Lymph node metastasis, tumor size, and TNM stage. Clinicopathological correlation analysis showed that the upregulation of LncRNA Hotair expression was closely related to lymph node metastasis and tumor lymph node metastasis (TNM) stage (P < 0.05). Yes The results showed that transfection of pcDNA3.1-Hotair could promote the expression of LncRNA Hotair in NSCLC, while transfection of Si-Hotair could reduce the expression level of LncRNA Hotair, hinder the migration and invasion of cancer cells, and promote cell apoptosis. 34777731 HOTAIR LncRNA Homo sapiens Cholangiocarcinoma CCA tissue samples and cell lines Expression[highly expressed] Western Blot//Wound Healing Assay//Tunel//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The results showed that HOTAIR was highly expressed both in CCA tissue samples and cell lines compared with corresponding normal bile duct tissues and Human intrahepatic biliary epithelial cells (HIBEC). Its overexpression was closely correlated with Tumor size, TNM stage and postoperative recurrence in CCA patients. Moreover, up-regulation of HOTAIR has correlation with prognosis in CCA patients. Yes Knockdown of HOTAIR by siRNAs significantly decreased the migration and invasion but increased apoptosis of CCA cells in vitro. 30111807 HOTAIR LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cell lines (HuB28 and HuCCT1) regulation[miR-204-5p/HMGB1 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay HOTAIR and HMGB1 were over-expressed, while miR-204-5p was lowly expressed in CCA tissues and cells.The restoration experiments showed that HOTAIR repressed cell apoptosis, autophagy and promoted cell proliferation via miR-204-5p/HMGB1 axis. Yes Additionally, HOTAIR silencing retarded the xenograft tumor growth by up-regulation of miR-204-5p and down-regulation of HMGB1. 32755793 HOTAIR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck blood Interaction[PTCSC3 ] qRT-PCR LncRNA HOTAIR was up-regulated in early stage LSCC patients and was significantly and inversely correlated with PTCSC3 in LSCC patients.Therefore, PTCSC3 may negatively interact with HOTAIR through STAT3 to inhibit LSCC cell proliferation. Yes PTCSC3 overexpression mediated the inhibited, while HOTAIR overexpression mediated the promoted proliferation of LSCC cells. 31171714 HOTAIR LncRNA Homo sapiens Thyroid Neoplasms thyroid tumor tissues Interaction(microRNA-761/PPME1) Flow Cytometry//In Vivo Experiment//Luciferase Report Assay//Western Blot HOTAIR was expressed to a significantly greater extent than miR-761 in thyroid tumor tissues (P < .001). miR-761 and PPME1 were negatively correlated (coef = -1.91, P < .001). HOTAIR competitively binds to miR-761 and miR-761 directly targets PPME1. HOTAIR was highly correlated with TNM (χ 2 = 5.797, P = .016), tumor size (χ 2 = 7.955, P = .005) and lymphatic metastasis (χ 2 = 6.0, P = .014). Yes HOTAIR promoted cell proliferation and inhibited cell apoptosis, whereas miR-761 did not. HOTAIR elevated and miR-761 suppressed PPME1 expression. HOTAIR expression appears to affect the survival time in vivo. 34195365 HOTAIR LncRNA Homo sapiens Retinoblastoma RB cell lines and Y79 and HXO-RB44 cells Interaction(miR-20b-5p/RRM2/PI3K/AKT axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Bioinformatics Analysis HOTAIR was elevated in RB cells relative to that in normal retinal cells and showed relatively high expression in Y79 and HXO-RB44 cells. sh-HOTAIR induced RB cell-cycle arrest, restrained proliferation, and strengthened apoptosis. HOTAIR functioned as the ceRNA of miR-20b-5p and targeted RRM2. RB cells had poorly-expressed miR-20b-5p and highly-expressed RRM2. miR-20b-5p downregulation or RRM2 overexpression facilitated RB cell-cycle and proliferation, suppressed apoptosis, and reversed the protective effect of sh-HOTAIR on RB. sh-HOTAIR reduced tumor growth and Ki67-positive cells in vivo and inactivated PI3K/AKT pathway. Yes HOTAIR functioned as the ceRNA of miR-20b-5p and targeted RRM2. RB cells had poorly-expressed miR-20b-5p and highly-expressed RRM2. miR-20b-5p downregulation or RRM2 overexpression facilitated RB cell-cycle and proliferation, suppressed apoptosis, and reversed the protective effect of sh-HOTAIR on RB. 35248107 HOTAIR LncRNA Homo sapiens Liver Neoplasms liver cancer tissues and cell lines interaction[miR-217] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay It was demonstrated that the expression of HOTAIR was upregulated in liver cancer tissues and 3 liver cancer cell lines (MHCC97H, HepG2 and Hep3B). Overall, HOTAIR contributes to the proliferation and growth of liver cancer via downregulation of miR-217. Yes Inhibition of HOTAIR with HOTAIR small interfering (si) RNA lentiviral vectors significantly suppressed the cell proliferation of HepG2 cells, and downregulated the protein expression levels of two proliferation markers, Ki67 and proliferating cell nuclear antigen (PCNA). 29849802 HOTAIR LncRNA Homo sapiens Esophageal Neoplasms oesophageal cancer tissues and adjacent normal tissues,cell lines(EC8712, EC8733, ECA109, EC9706 , EC8501 ,HEEC) Interaction[regulate miR-204 and HOXC8 ] RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The immunohistochemistry (Figure ​(Figure1E,F)1E,F) and RT‐qPCR (Figure ​(Figure1G)1G) results demonstrated that compared with the adjacent normal tissues, the positive expression rate of HOXC8 as well as the expression of HOTAIR was considerably elevated in the oesophageal cancer tissues, while the expression of miR‐204 was notably decreased. In summary, our results show that lncRNA HOTAIR could specifically bind to miR-204 as a competing endogenous RNA and regulate miR-204 and HOXC8. Yes Silenced HOTAIR or elevated miR-204 inhibited proliferation, migration and invasion, along with stimulated apoptosis of oesophageal cancer cells. 31389660 HOTAIR LncRNA Homo sapiens Diabetic Nephropathies HMC Interaction( miR-147a/WNT2B axis) Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining LncRNA HOTAIR could serve as a sponge of miR-147a. The inhibition effect of lncRNA HOTAIR silencing on the biological functions of HG-induced HMC could be reversed by miR-147a inhibitor. WNT2B was targeted by miR-147a, and its overexpression also overturned the suppressive effect of miR-147a on the proliferation, fibrosis, and oxidative stress of HG-induced HMC. Yes Our data showed that lncRNA HOTAIR knockdown could inhibit the proliferation, fibrosis, and oxidative stress in HG-induced HMC. 35193668 HOTAIR LncRNA Homo sapiens Endometriosis ectopic endometrial tissues and cells Interaction(miR-519b-3p/PRRG4 pathway) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay The qRT-PCR results showed that the average relative expression of LncRNA HOTAIR was much higher in ectopic endometrial tissues than in eutopic endometrial tissues. Bioinformatics analysis suggested that the downstream target genes of LncRNA HOTAIR were miR-519b-3p and Prrg4. Knockdown of LncRNA HOTAIR can reduce the up-regulation of Prrg4 by miR-519b-3p and then inhibit the invasion and migration ability of endometrial stromal cells. Yes Scratch and transwell assays showed that the cell migration and invasion ability of LncRNA HOTAIR overexpression group was significantly higher than those in the control group. Conversely, the LncRNA HOTAIR knockdown group showed the opposite results. 36338672 HOTAIR LncRNA Homo sapiens Arthritis, Rheumatoid HFLSs Interaction(miR-106b-5p/Smad7 axis) Western Blot//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay The qRT-PCR results indicated that the expression of lncRNA HOTAIR was markedly decreased and that of miR-106b-5p was markedly increased in HFLSs of RA. Smad7 was identified as a target gene of miR-106b-5p, and the effects of downregulation of miR-106b-5p on HFLSs could be abolished by silencing Smad7. We found that lncRNA HOTAIR was significantly downregulated in the HFLSs of patients with RA. Moreover, lncRNA HOTAIR influenced cell growth, migration, invasion, and apoptosis in HFLSs through the miR-106b-5p/Smad7 axis. Yes Cell proliferation, invasion, and migration of HFLSs were inhibited by lncRNA HOTAIR upregulation, and the expression of miR-106b-5p was negatively regulated by lncRNA HOTAIR in HFLSs. Apoptosis of HFLS cells was improved by the overexpression of lncRNA HOTAIR. All the effects of lncRNA HOTAIR upregulation on HFLSs were reversed after the overexpression of miR-106b-5p. 36164683 HNF1A-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-124/MYO6] qRT-PCR//Luciferase Report Assay//RIP//Western Blot In this study, we found that HNF1A-AS1 was upregulated in CRC tissues and cell lines. In this study, we first found that HNF1A-AS1 regulated cell migration, invasion and glycolysis via modulating miR-124/MYO6 in CRC cells. Yes Functional experiments determined that reduction of HNF1A-AS1 or promotion of miR-124 inhibited cell migration and invasion as well as glycolysis in CRC cells. 32110048 HNF1A-AS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues and cell lines interaction[PBX3] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//ChIP HNF1A-AS1 and OTX1 were highly expressed in colon cancer. Further, HNF1A-AS1 upregulated OTX1 to activate the ERK/MAPK pathway. Yes Silencing of HNF1A-AS1 inhibited angiogenesis of colon cancer in vivo and in vitro. 32325080 HNF1A-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Regulation[ Notch signaling pathway ] Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//MTT//Luciferase Report Assay//Colony Formation Assay//ChIP The high expression of HNF1A-AS1 was examined in OSCC tissues and cell lines.Mechanically, HNF1A-AS1 was positively regulated by the transcription factor STAT3. Recently, Notch signaling pathway has been reported in human malignancies. In this study, we analyzed the correlation between HNF1A-AS1 and Notch signaling pathway. It was uncovered that the expression of Notch1 and Hes1 (the core factors of Notch signaling pathway) was negatively regulated by HNF1A-AS1 knockdown. Rescue assays further demonstrated the positive regulatory effects of HNF1A-AS1 on Notch signaling pathway in OSCC. In conclusion, upregulation of HNF1A-SA1 induced by transcription factor STAT3 promotes OSCC progression by activating Notch signaling pathway. Yes Results of loss-of-function assays demonstrated that silenced HNF1A-AS1 inhibited the proliferation, migration and epithelial-mesenchymal transition (EMT) of OSCC cells. 30404566 HNF1A-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells regulation[miR-32-5p/HMGB1 Axis] Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay HNF1A-AS1 and HMGB1 were upregulated, while miR-32-5p was downregulated, in OS tissues and cells. Downregulation of HNF1A-AS1 blocked OS progression through the miR-32-5p/HMGB1 axis, which provides a possible target and prognostic biomarker for treatment of OS. Yes Functionally, HNF1A-AS1 depletion induced apoptosis and impeded proliferation, migration, and invasion of OS cells. 32706998 HIPK3 CircRNA Homo sapiens Uterine Cervical Neoplasms cell lines regulation[ miR-485-3p/FGF2 axis] colony Formation Assay//Western Blot//qRT-PCR//PCR//Colony Formation Assay//IF This study confirmed that circHIPK3 was highly expressed in CC tissues.Overexpression of circHIPK3 triggered the upregulation of FGF2 expression while knockdown of circHIPK3 reduced FGF2 expression in CC cells, and the transfection of miR-485-3p mimics reversed the upregulation of FGF2 expression and enhanced malignant phenotypes in CC cells with overexpressed circHIPK3. Yes Overexpressed circHIPK3 could remarkably expedite the proliferation, migration and invasion of SiHa cells, and knocking down circHIPK3 could significantly impede the proliferation, migration and invasion of HeLa cells. 33177072 HIPK3 CircRNA Homo sapiens Uterine Cervical Neoplasms CC cells and tissues regulation[ circ-HIPK3/miR-338-3p/HIF-1α axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down circ-HIPK3 expression was significantly elevated in CC cells and tissues.Therefore, targeting circ-HIPK3/miR-338-3p/HIF-1α axis may be a novel therapeutic strategy for CC. Yes circ-HIPK3 silence repressed growth and metastasis, while induced apoptosis in CC cells. 32021434 HIPK3 CircRNA Homo sapiens Prostatic Neoplasms serum of PCa patients Interaction(miR-212/BMI-1 pathway) Western Blot//Transfection//Flow Cytometry//qRT-PCR//IF//MTT//PCR//Transwell Assay Exosomal circHIPK3 was increased in serum of PCa patients, and could discriminate PCa patients from normal volunteers. MiR-212 targeted BMI-1, and downregulated BMI-1 expression.Exosomal circHIPK3 knockdown inhibited PCa progression by regulating miR-212/BMI-1 axis, at least in part, offering a new insight into the molecular mechanism of PCa. Yes Depletion of exosomal circHIPK3 or overexpression of exosomal miR-212 reduced viability, migration and invasion, but promoted cell apoptosis in PCa cells, which was attenuated by miR-212 inhibition or BMI-1, respectively. Exosomal circHIPK3 knockdown also suppressed tumor growth in vivo. 34313249 HIPK3 LncRNA Homo sapiens Acute Kidney Injury septic AKI patients and LPS-triggered HK2 cells Interaction( microRNA-338/forkhead box A1 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA The results displayed that circHIPK3 expression was enhanced in septic AKI patients and LPS-triggered HK2 cells. Furthermore, circHIPK3 functioned as a molecular sponge for miR-338, and forkhead box A1 (FOXA1) was negatively regulated by miR-338. CircHIPK3 aggravated cell injury in LPS-treated HK2 via targeting miR-338, and FOXA1 addition overturned the suppressing impacts of miR-338-3p augmentation on LPS-activated HK2 cell damage. Finally, we demonstrated that circHIPK3 modulated LPS-induced cell damage via the miR-338/FOXA1 axis. Yes Moreover, circHIPK3 interference expedited HK2 cell viability and attenuated apoptosis, inflammatory and oxidative damages following LPS stimulation. 35148669 Hipk3 CircRNA Mus musculus Diabetic Nephropathies renal tissues of mice with DN Interaction( miR-185) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay Up-regulation of circHIPK3 was observed in the renal tissues of mice with DN. Similarly, circHIPK3 expression in rat mesangial cells increased significantly in a microenvironment of high glucose. Luciferase assay demonstrated that circHIPK3 can specifically sponge miR-185, and silencing of miR-185 can reverse the effects of knocking down circHIPK3 on cell proliferation and mRNA abundance of cyclin D1, PCNA, TGF-β1, Col. I, and FN in MCs. Yes A loss-of-function experiment indicated that down-regulation of circHIPK3 inhibited cell proliferation and significantly decreased mRNA abundance of cyclin D1, PCNA, TGF-β1, Col. I, and FN in MCs. 32889056 Hipk3 CircRNA Mus musculus Spinal Cord Injuries SCI rat models regulation[ Circ-HIPK3/miR-558/DPYSL5 axis ] RNA Pull-Down//Western Blot//Tunel//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay In this study, circ-HIPK3 was found lowly expressed in SCI rat models and AGE1.HN and PC12 cells induced by 100uM of CoCl2. Circ-HIPK3/miR-558/DPYSL5 axis modulated the apoptosis of AGE1.HN and PC12 cells in SCI. Yes Meanwhile, inhibited circ-HIPK3 or overexpressed circ-HIPK3 could separately elevate or reduce the apoptosis of AGE1.HN and PC12 cells. 32247616 HIPK2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cancer tissues Expression(highly expressed) qRT-PCR Circular RNA circ HIPK2 expressions were up-regulated in patients with non-small cell lung cancer, compared with paracancerous tissue. Circular RNA circ HIPK2 expressions in III-IV patients with non-small cell lung cancer were higher than those of I-II patients. Overall survival rate and disease-free survival rate of patients with high circ HIPK2 expression were lower than those of patients with low circ HIPK2 expression. Yes Circ HIPK2 promoted cell proliferation of non-small cell lung cancer. MiR-485-5p is a target for circ HIPK2 in non-small cell lung cancer; it reduced cell proliferation and accelerated HSP90 Ubiquitination in non-small cell lung cancer. 35181624 HIF2PUT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation(HIF-2a) CCK8//qRT-PCR//Transwell Assay lncRNA HIF2PUT was downregulated in NSCLC tissues and cell lines. Furthermore, they found that HIF2PUT plays role in cell proliferation and invasion in NSCLC through regulating HIF-2a. Moreover, low expression of HIF2PUT was significantly related to TNM stage (p = 0.045) and histological type (p = 0.025). Yes The authors also indicated that HIF2PUT mainly expressed in cytoplasm and overexpression of HIF2PUT attenuates cell proliferation and invasion in NSCLC cells. 34287062 HIF2PUT LncRNA Homo sapiens Osteosarcoma cell lines Interaction[regulating HIF2] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay LncRNA HIF2PUT and HIF-2α were downregulated in osteosarcoma cell lines.Increased HIF2PUT expression inhibited the enrichment of CD133 in osteosarcoma stem cells. There was a strong positive correlation between relative HIF2PUT level and relative HIF-2α level in the 30 paired osteosarcoma cancer tissues. Yes Wound healing and transwell assays showed that lncRNA overexpression inhibited osteosarcoma stem cell migration and invasion. 30966832 HIF1A-AS2 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-429/PD-L1 Axis) In Vivo Experiment//Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay HIF1A-AS2 was elevated in GC tissues and cell lines.. Moreover, HIF1A-AS2 directly bound to miR-429 based on bioinformatics prediction and luciferase assay, and inhibition of miR-429 abolished the effects of HIF1A-AS2 knockdown on GC cells. Furthermore, miR-429 directly targeted PD-L1, and overexpression of miR-429 suppressed GC tumorigenesis via PD-L1. Yes Functional experiments showed that HIF1A-AS2 knockdown inhibited GC cell proliferation, migration, and invasion in vitro, as well as hindered tumor growth in vivo. 33555514 HIF1A-AS2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[miR-153-5p/S100A14 Axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay HIF1A-AS2 expression was raised in NSCLC tissues and cell lines. The HIF1A-AS2/miR-153-5p/S100A14 axis plays a crucial role in promoting NSCLC progression. High HIF1A-AS2 expression was related to poor prognosis. Yes HIF1A-AS2 knockdown decreased proliferation, migration and invasion while promoting apoptosis. 32922043 HIF1A-AS2 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues Expression[highly expressed] qRT-PCR aHIF levels were increased in EOC tissues and were upregulated by hypoxia in EOC cells. Yes Functional data revealed that aHIF knockdown accelerated cell apoptosis under hypoxia and inhibited EOC tumorigenesis and tumor growth in vivo. 30588022 HIF1A-AS2 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Regulation[HIF1A-AS2-miR-33b-5p-SIRT6 axis] RNA Pull-Down//Western Blot//ISH//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//IHC In this study, we demonstrated that HIF1A-AS2 was overexpressed in OS tissues and cells.Taken together, a newly identified regulatory mechanism for the lncRNA HIF1A-AS2-miR-33b-5p-SIRT6 axis was systematically studied in OS, which could be a promising target for the treatment of OS. Yes Downregulation of HIF1A-AS2 significantly affects multiple biological functions in OS cells, including cell proliferation, cell cycle progression, cell apoptosis, cell migration, and cell invasiveness. 31626739 HIF1A-AS2 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Interaction[as a sponge of miR-129-5p] CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay We showed that the expression of HIF1A-AS2 was upregulated in the osteosarcoma samples compared with the expression in noncancerous samples. In addition, overexpression of HIF1A-AS2 promoted cell proliferation, cell cycle progression and invasion of osteosarcoma cells through the modulation of miR-129-5p. Moreover, patients with high HIF1A-AS2 expression had a shorter overall survival. Yes Ectopic expression of HIF1A-AS2 enhanced osteosarcoma cell proliferation, cell cycle progression and invasion. 31866584 HIF1A-AS2 LncRNA Homo sapiens Uterine Cervical Neoplasms HPV- positive cervical cancer cells Regulation(P53/caspase9/caspase3 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//EdU Staining//ChIP HIF1A-AS2 was significantly increased in cervical cancer tissue, and in the HPV- positive cervical cancer cells. In terms of mechanism, we found that HIF1A-AS2 was mediated by HPV16 E6 and regulated cell apoptosis via P53/caspase 9/caspase 3 axis. Yes Further investigation showed that the inhibition of HIF1A-AS2 suppressed cell proliferation, migration, invasion, and induced apoptosis, while up-regulation of HIF1A-AS2 revealed opposite results. 35728704 HIF1A-AS2 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues,cell lines Expression[highly expressed] qRT-PCR//Transwell Assay In our results, HIF1A-AS2 was also found to be upregulated in TNBC tissues compared with non-TNBC tissues or adjacent normal tissues. Besides, HIF1A-AS2 expression was also elevated in TNBC cell lines compared with the normal breast epithelial cell line. Moreover, high expression of HIF1A-AS2 was associated with lymph node metastasis, distant metastasis and unfavorable histological grade in TNBC patients. Survival analysis showed a TNBC patient with high HIF1A-AS2 expression had shorter overall survival than patients with low HIF1A-AS2 expression, and HIF1A-AS2 high expression acted as an independent poor prognostic factor for overall survival in TNBC patients. Yes The cell migration and invasion assays suggested inhibition of HIF1A-AS2 obviously depressed TNBC cell migration and invasion. 30635931 HIF1A-AS2 LncRNA Homo sapiens Adenocarcinoma of Lung 129 LUAD tissues and paired adjacent non-tumor tissues (n = 56) Interaction(miR-146b-5p/IL-6/STAT3 axis) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay//IHC//Invasion Assay Using clinical samples, we showed that HIF1A-AS2 was upregulated in LUAD specimens, predicting poorer overall survival and disease-free survival. RNA precipitation assays, western blotting, luciferase assays, and rescue experiments demonstrated that HIF1A-AS2 sponged microRNA-146b-5p (miR-146b-5p), promoting interleukin-6 (IL-6) expression, activating the IL-6/STAT3 pathway, and leading to LUAD progression. Using clinical samples, we showed that HIF1A-AS2 was upregulated in LUAD specimens, predicting poorer overall survival and disease-free survival. miR-146b-5p and IL-6 levels were correlated with the prognosis of LUAD patients. Yes HIF1A-AS2 silencing inhibited the proliferation, migration, and tumorigenesis of LUAD cells and therapeutic efficacy of osimertinib against tumor cells in vitro and in vivo. 34703647 HIF1A-AS2 LncRNA Homo sapiens Carcinoma, Renal Cell kidney cancer tissues and ccRCC cells regulation[miR-130a-5p/ERBB2 Pathway] qRT-PCR//Luciferase Report Assay//Western Blot HIF1A-AS2 was highly expressed in kidney cancer tissues and ccRCC cells.Our results indicated a critical role for the HIF1A-AS2-miR-130a-5p axis in renal carcinoma progression, which may act as a promising diagnostic biomarker and a pivotal therapeutic target for renal carcinoma cures. Yes Interference of HIF1A-AS2 in vivo hindered cell proliferation, invasion and migration while accelerated cell apoptosis. 33061459 HIPK3 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues or cells Interaction(micro RNA-124 or micro RNA-506/pyruvate dehydrogenase kinase 2 axis) qRT-PCR We found that circHIPK3 was upregulated in HCC patients and associated with clinical characteristics, while miR-124 and miR-506 were downregulated in HCC patients. Additionally, we proved that knock down of circHIPK3 remarkably suppressed the proliferation and invasion of HCC cells. Mechanistically, circHIPK3 directly bound to miR-124 or miR-506 and inhibited their expression, and PDK2 was a target gene of miR-124 or miR-506. Moreover, circHIPK3 overexpression reversed the inhibitory effect of miR-124 or miR-506 on HCC progression. miR-124 or miR-506 could also suppress tumorigenesis of HCC cells by PDK2. Furthermore, in vivo evidence confirmed that knock down of circHIPK3 inhibited tumor formation. We suggest that circHIPK3 can accelerate the proliferation and invasion of HCC cells by sponging miR-124 or miR-506 to upregulate PDK2, which is the underlying mechanism of circHIPK3-induced HCC progression. We found that circHIPK3 was upregulated in HCC patients and associated with clinical characteristics, while miR-124 and miR-506 were downregulated in HCC patients Yes Additionally, we proved that knock down of circHIPK3 remarkably suppressed the proliferation and invasion of HCC cells. Mechanistically, circHIPK3 directly bound to miR-124 or miR-506 and inhibited their expression, and PDK2 was a target gene of miR-124 or miR-506. 35212603 HIPK3 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues，cell line（16HBE ，SPC-A1, A549, NCI-H1299, and NCI-H1650） Interaction[miR-130a-3p-PTEN/p22] CCK8//qRT-PCR In the present study, the level of circRNA-HIPK3 were measured by Taq-man based quantitative real-time PCR (qRT-PCR) analysis in both NSCLC patient specimens and cells, which showed that circRNA-HIPK3 was Expression[Expression[up-expression]-expression]regulated in both NSCLC tissues and cell lines.In the present study, the level of circRNA-HIPK3 were measured by Taq-man based quantitative real-time PCR (qRT-PCR) analysis in both NSCLC patient specimens and cells, which showed that circRNA-HIPK3 was Expression[Expression[up-expression]-expression]regulated in both NSCLC tissues and cell lines. Yes MiR-193a expression was increased by circHIPK3 silencing. We then showed that miR-149 interacts with FOXM1 by binding to the 3'-untranslated region (UTR). Further, ectopic overexpression of miR-149 by transfecting miR-149 mimics significantly inhibited growth, migration and invasion of HSCLCs, which was found to be mediated through FOXM1. Moreover, miR-149 overexpression decreases the viability and proliferation of HSCLCs. Therefore, our data suggest that circHIPK3 regulates the function of NSCLCs through miR-149-mediated FOXM1 expression regulation, potentially providing a novel insight into the pathogenesis of NSCLC. 31597523 HIST1H2AG-6 LncRNA Homo sapiens Diabetes Mellitus, Type 2 peripheral blood mononuclear cells Regulation(lower expressed) qRT-PCR The microarray analysis revealed that there were 55 lncRNAs and 36 mRNAs differentially expressed in patients with T2DM compared with healthy controls. Notably, lnc-HIST1H2AG-6 was significantly upregulated and lnc-AIM1-3 was significantly downregulated in patients with T2DM, which was validated in a large-scale qRT-PCR examination (90 controls and 100 patients with T2DM). Spearman's rank correlation coefficient revealed that both lncRNAs were correlated with 36 differentially expressed mRNAs. Furthermore, functional enrichment (KEGG and GO) analysis demonstrated that the two lncRNA-related mRNAs might be involved in multiple biological functions, including cell programmed death, negative regulation of insulin receptor signal, and starch and sucrose metabolism. Multivariate logistic regression analysis revealed that lnc-HIST1H2AG-6 and lnc-AIM1-3 were significantly correlated with T2DM (OR = 5.791 and 0.071, respectively, both P = 0.000). Furthermore, the ROC curve showed that the expression of lnc-HIST1H2AG-6 and lnc-AIM1-3 might be used to differentiate patients with T2DM from healthy controls (area under the ROC curve = 0.664 and 0.769, respectively). Yes Notably, lnc-HIST1H2AG-6 was significantly upregulated and lnc-AIM1-3 was significantly downregulated in patients with T2DM, which was validated in a large-scale qRT-PCR examination (90 controls and 100 patients with T2DM). Spearman's rank correlation coefficient revealed that both lncRNAs were correlated with 36 differentially expressed mRNAs. Furthermore, functional enrichment (KEGG and GO) analysis demonstrated that the two lncRNA-related mRNAs might be involved in multiple biological functions, including cell programmed death, negative regulation of insulin receptor signal, and starch and sucrose metabolism. 34092238 HMMR-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and HCC cells Interaction(miR-147a/ARID3A axis) qRT-PCR LncRNA HMMR-AS1 was significantly up-regulated in HCC tissues and HCC cells and was related to the poor prognosis. Further study of the mechanism showed that HMMR-AS1 could competitively bind to miR-147a to prevent the degradation of ARID3A. Yes Inhibiting the expression of HMMR-AS1 could significantly inhibit tumor growth in vitro and in vivo. 35179300 HNF1A-AS1 LncRNA Homo sapiens Esophageal Neoplasms ESCC tumor tissues and cells Interaction(miR-298/TCF4 axis) qRT-PCR//RIP//Western Blot HNF1A-AS1 was overexpressed in ESCC tumor tissues and cells. miR-298 was validated as a direct target of HNF1A-AS1. In conclusion, knockdown of HNF1A-AS1 could inhibit EMT and stemness by regulating the miR-298/TCF4 axis. Yes sh-HNF1A-AS1 significantly inhibited EMT and stemness of ESCC cells. Animal experiments showed that sh-HNF1A-AS1 significantly inhibited tumor growth and increased the level of miR-298 in tissues. 35188404 HNF1A-AS1 LncRNA Homo sapiens Glioma cell lines regulation[miR-32-5p/SOX4 axis] Flow Cytometry//qRT-PCR//Transwell Assay//Western Blot The results demonstrated that HNF1A-AS1 was predominantly highly expressed in glioma cell lines compared with nontumor glial epithelial cell, which was associated with the stimulation of transcription factor myelocytomatosis oncogene.HNF1A-AS1 exerted oncogenic property in glioma progression via upregulating miR-32-5p-mediated SOX4 expression, suggesting potential novel therapeutic target for future glioma treatment. Yes Knockdown of HNF1A-AS1 remarkably inhibited glioma cells proliferation, migration, and invasion, while accelerating cell apoptosis in vitro. 33448691 HNF1A-AS1 LncRNA Homo sapiens Glioblastoma clinical samples Interaction(miR-22-3p/ENO1 axis) In Vivo Experiment//ChIP//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay In the current study, we analyzed clinical samples to show that the HNF1A-AS1 expression is upregulated and associated with poor patient survival in GBM. Mechanistically, the transcription factor EGR1 forced the HNF1A-AS1 expression by directly binding the promoter region of HNF1A-AS1. Furthermore, combined bioinformatics analysis with our mechanistic work, using luciferase reporter assays and RIP, we first demonstrated that HNF1A-AS1 functions as a competing endogenous RNA (ceRNA) with miR-22-3p to regulate ENO1 expression in GBM cells. HNF1A-AS1 directly binds to miR-22-3p and significantly inhibits miR-22-3p expression, while ENO1 expression was increased. In the current study, we analyzed clinical samples to show that the HNF1A-AS1 expression is upregulated and associated with poor patient survival in GBM. Yes Functional studies revealed that HNF1A-AS1 knockdown markedly inhibits malignant phenotypes of GBM cells, whereas overexpression of HNF1A-AS1 exerts opposite effect. 34772911 HNF1A-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[targeting miR-149-5p/Cdk6] qRT-PCR In the current study, we found that HNF1A-AS1 was relatively upregulated in both NSCLC patient tissues and cell lines. miR-149-5p was then proved to be a novel target of HNF1A-AS1, whose expression was negatively correlated with HNF1A-AS1 in NSCLC patient tissues and cell lines. HNF1A-AS1 increased the expression of cyclin-dependent kinase 6 (Cdk6) via sponging with miR-149-5p. Gain- and loss-of-functional studies indicated that HNF1A-AS1 promoted NSCLC progression partially through inhibition of miR-363-3p and induction of Cdk6. Subcutaneous xenotransplanted tumor model confirmed that interference of HNF1A-AS1 suppressed the tumorigenic ability of NSCLC via upregulation of miR-149-5p and downregulation of Cdk6 in vivo. In conclusion, our findings clarified the biologic significance of the HNF1A-AS1/miR-149-5p/Cdk6 axis in NSCLC progression and provided novel evidence that HNF1A-AS1 may be a new potential therapeutic target for the treatment of NSCLC. Yes Functional studies established that overexpression of HNF1A-AS1 promoted cell proliferation, cell cycle, invasion, and migration of NSCLC cells in vitro. The promotion abilities of HNF1A-AS1 on NSCLC cell progression were suppressed via knockdown of HNF1A-AS1. 31243821 HNF1A-AS1 LncRNA Homo sapiens neuroendocrine carcinoma gastric NENs tissues Expression(lower expressed) Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay HNF1A-AS1 expression was decreased in gastric NENs tissues (p < 0.01). Oncostatin M was identified as the downstream target of HNF1A-AS1. Inhibition of transforming growth factor-β activity inhibited HNF1A-AS1/Oncostatin M-mediated epithelial-mesenchymal transition. Yes Over-expression of HNF1A-AS1 suppressed cellular proliferation, migration and invasion. Knockdown of transcription factor 3 inhibited the expression of HNF1A-AS1 and promoted cellular migration and invasion. 34037532 HNF1A-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(HNF1A-AS1/IGF2BP2/CCND1) In Vivo Experiment//Transfection//Immunoblotting//Tube Formation Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//Transwell Assay Our results showed that HNF1A-AS1 was upregulated in CRC and associated with unfavorable prognosis. Bioinformatics prediction and further experiments proved that HNF1A-AS1 could promote CCND1 expression by suppressing PDCD4 or competitively sponging miR-93-5p. Meanwhile, METTL3 mediated HNF1A-AS1 m6A modification and affected its RNA stability. HNF1A-AS1/IGF2BP2/CCND1 may act as a complex to regulate the stability of CCND1. Yes HNF1A-AS1 promoted proliferation, migration and angiogenesis, accelerated cell cycle and reduced cell apoptosis in CRC. 36230970 Hmrhl LncRNA Homo sapiens Leukemia, Myelogenous, Chronic, BCR-ABL Positive K562 cell line Expression [highly expressed] Transfection//Migration Assay//qRT-PCR//FISH//RNA-seq//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Invasion Assay//Transwell Assay Results indicate its high expression in CML patient samples as well as in K562 cell line. Yes Silencing experiments suggest role of Hmrhl in cell proliferation, migration & invasion. RNA-seq and ChiRP-seq data analysis further revealed its association with important biological processes, including perturbed expression of crucial TFs and cancer-related genes. 34734184 HMMR-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Regulation[MiR-138/sirt6 axis] Western Blot//ISH//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining HMMR-AS1 expression was significantly upregulated in LUAD tissues and was associated with larger tumor diameter, advanced TNM stage, lymph node metastasis, and shorter survival. Taken together, HMMR-AS1 is significantly over-expressed in LUAD, and HMMR-AS1-miR-138-sirt6 axis play a critical role in LUAD tumorigenesis. Our findings highlight an oncogenic role of HMMR-AS1 in LUAD. HMMR-AS1 expression was significantly upregulated in LUAD tissues and was associated with larger tumor diameter, advanced TNM stage, lymph node metastasis, and shorter survival. Yes Knockdown of HMMR-AS1 induced apoptosis and growth arrest in vitro and inhibited tumorigenesis in mouse xenografts. 31128573 HIT000218960 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction[Expression[highly expressed]regulation of HMGA2] CCK8//qRT-PCR//Western Blot HIT000218960 and HMGA2 were highly expressed in GC tissues compared with in healthy tissues. The HIT000218960 expression level was associated with tumor size, Tumor-Node-Metastasis staging and lymph node metastasis in patients with GC. Yes HIT000218960 silencing decreased the proliferative and migratory ability of HGC27 and NCI-N87 cells; however, HMGA2 overexpression partly reversed this inhibitory effect. 31186705 HMGN2P17 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[lower expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 HMGA1-lnc LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor and matched non-malignant tissues from 36 LUAD patients Expression [highly expressed] RNA-seq We identified the lncRNA RP11.513I15.6, which we refer to as HMGA1-lnc, neighboring HMGA1 to be significantly downregulated in both LUAD cohorts. Conversely, we found HMGA1 significantly overexpressed in LUAD and anticorrelated with HMGA1-lnc. Yes In vitro experiments demonstrated siRNA-mediated inhibition of HMGA1-lnc in immortalized non-malignant lung epithelial cells resulted in a significant increase in HMGA1 gene expression. 33505435 HLNC1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC samples and cell lines interaction[USP49] qRT-PCR We found that HLNC1 was markedly upregulated in HCC samples and cell lines.HLNC1-USP49 interaction dramatically destabilized USP49. Yes HLNC1 could promote viability and migration of HCC cells. 32691951 HLA-F-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation[HLA-F-AS1/miR-330-3p/PFN1 axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Expressions of HLA-F-AS1 and PFN1 were significantly up-regulated while miR-330-3p was significantly down-regulated in CRC tissues and cell lines.HLA-F-AS1 promoted CRC progression via regulating miR-330-3p/PFN1 axis. Yes Over-expressions of HLA-F-AS1 or transfection of miR-330-3p inhibitors could promote the proliferation, migration and invasion and block apoptosis of CRC cells, whereas knockdown of HLA-F-AS1 or transfection of miR-330-3p mimics led to the opposite effects. 31863778 HLA-F-AS1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cells Interaction(miR-21-3p/PEG3 axis) qRT-PCR//Western Blot Among the ovarian cancer tissues and cells, the expressions of PEG3 and lncRNA HLA-F-AS1 were depleted while an elevated miR-21-3p expression was observed. MiR-21-3p targeted PEG3 3'UTR while HLA-F-AS1 targeted miR-21-3p. HLA-F-AS1 overexpression mitigated the enhancement brought about by miR-21-3p mimic on ovarian cancer cells' proliferation and migration. Meanwhile, PEG3 overexpression abrogated miR-21-3p mimic's function as an oncogene in the progression of ovarian cancer. Yes HLA-F-AS1's overexpression attenuated ovarian cancer development in vivo and in vitro . 35276697 HLA-F-AS1 LncRNA Homo sapiens Glioblastoma 62 GBM tumors Interaction(lncRNA MEG3) RNA Pull-Down//Transfection//qPCR//Cell Apoptosis Assay//Transwell Assay HLA-F-AS1 was highly expressed, and MEG3 was downregulated in GBM. Overexpression of HLA-F-AS1 reduced the expression levels of MEG3 while overexpression of MEG3 did not alter the expression of HLA-F-AS1. Yes HLA-F-AS1 increased cell migration and invasion, but decreased cell apoptosis. MEG3 played opposite roles and reduced the effects of HLA-F-AS1 on cell behaviors. 34934358 HLA-F-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Interaction(miR-541-3p/TRABD) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//Colony Formation Assay Our findings demonstrated that HLA-F-AS1 expression was significantly upregulated in TNBC tissues and cells, and high level of HLA-F-AS1 indicated the poor prognosis of patients with TNBC. HLA-F-AS1. In addition, signal transducer and activator of transcription 3 (STAT3) transcriptionally induced HLA-F-AS1 upregulation in TNBC cells via interacting with HLA-F-AS1 promoter. Moreover, HLA-F-AS1 acted as the molecular sponge of microRNA 541-3p (miR-541-3p) to elevate TRABD (TraB domain containing) expression in TNBC cells. Our findings demonstrated that HLA-F-AS1 expression was significantly upregulated in TNBC tissues and cells, and high level of HLA-F-AS1 indicated the poor prognosis of patients with TNBC. Yes HLA-F-AS1 promoted TNBC progression by facilitating cell proliferation and stemness maintenance and inhibiting cell cycle arrest at G0/G1 stage and apoptosis in vitro as well as inducing tumor growth in vivo.Rescue experiments confirmed that the decrease of cell proliferation and stemness characteristics under silenced HLA-F-AS1 was rescued by TRABD overexpression in TNBC cells. 33618253 HIVEP2-DT LncRNA Homo sapiens Osteoarthritis damaged cartilage from patients with OA and in human articular chondrocytes Interaction(DHX9/TAK1/NF-κB signaling) RNA Pull-Down//ChIP//Western Blot//FISH//qRT-PCR//RIP//Luciferase Report Assay//IF The abundance of PILA was increased in damaged cartilage from patients with OA and in human articular chondrocytes stimulated with the proinflammatory cytokine tumor necrosis factor (TNF). PILA promoted PRMT1-mediated arginine methylation of DExH-box helicase 9 (DHX9), leading to an increase in the transcription of the gene encoding transforming growth factor β-activated kinase 1 (TAK1), an upstream activator of NF-κB signaling. Furthermore, intra-articular injection of an adenovirus vector encoding PILA triggered spontaneous cartilage loss and exacerbated posttraumatic OA in mice. Yes Knockdown of PILA inhibited TNF-induced NF-κB signaling, extracellular matrix catabolism, and apoptosis in chondrocytes, whereas ectopic expression of PILA promoted NF-κB signaling and matrix degradation. 35609127 HOXD-AS2 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines interaction[targeting HOXD8 and activating PI3K/Akt signaling pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Mechanistic studies revealed that HOXD-AS2 regulated the expression of its nearby gene HOXD8 and inhibited the activity of the PI3K/Akt signaling pathway. The low expression of lncRNA HOXD-AS2 was associated with lymph node metastasis and tumor-node-metastasis stage in GC. Yes In vitro functional experiments demonstrated that overexpression of HOXD-AS2 inhibited GC cell progression. 33250958 hsa_circ_0001361 LncRNA Rattus norvegicus Adenocarcinoma of Lung LUAD tissues and cells Interaction(miR-525-5p/VMA21 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Circ_0001361 was up-regulated, while miR-525-5p was down-regulated in LUAD tissues and cells. Functional experiments demonstrated that circ_0001361 drove LUAD cell growth and metastasis. Mechanistically, circ_0001361 functioned as a sponge of miR-525-5p to up-regulate downstream target VMA21 level. MiR-525-5p/VMA21 axis was involved in circ_0001361-mediated malignant phenotypes of LUAD cells. Finally, inhibition of circ_0001361 restrained in vivo xenograft tumor growth via regulating miR-525-5p/VMA21 axis. Yes Functional experiments demonstrated that circ_0001361 drove LUAD cell growth and metastasis. 34507559 ELFN1-AS1 LncRNA Homo sapiens Colorectal Neoplasms cancer tissues and cell lines Interaction(MYC/ELFN1-AS1/EZH2/FOXP1/TPM1 ) qRT-PCR//Luciferase Report Assay//ChIP ELFN1-AS1 was transcriptionally activated by MYC. Moreover, ELFN1-AS1 led to transcriptional silencing of tropomyosin 1 (TPM1) via recruiting enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) and forkhead box P1 (FOXP1). Collectively, MYC-upregulated ELFN1-AS1 recruited EZH2 and FOXP1 to restrain TPM1 expression, thereby promoting colorectal cancer tumor growth. Yes ELFN1-AS1 knockdown inhibited colorectal cancer tumor growth through restricting cell proliferation and facilitating cell apoptosis. 35857351 LCIIAR LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines Interaction( LCIIAR/hsa-miR184/SLC16A3/CDCP1 network) Transfection//qRT-PCR//FISH//migration assay//Cell Proliferation Assay We show that increase LCIIAR expression correlated with poor clinical stage and adverse clinical outcomes and that could also serve as an independent unfavorable prognostic factor in patients with Lung Adenocarcinima. We also demonstrated that the LCIIAR/hsa-miR184/SLC16A3/CDCP1 network regulates SLC16A3/CDCP1 overexpression in and is associated with poor prognosis in this tumour. We show that increase LCIIAR expression correlated with poor clinical stage and adverse clinical outcomes and that could also serve as an independent unfavorable prognostic factor in patients with Lung Adenocarcinima. Yes More importantly, we confirmed that silencing of LCIIAR expression significantly inhibits the proliferation, and migration abilities of these tumour cells. 35860557 LCAT1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Regulation[LCAT1-miR-4715-5p-RAC1/PAK1 axis ] RIP//Luciferase Report Assay LCAT1 is an oncogene that is significantly upregulated in lung cancer tissues and associated with poor prognosis. LCAT1-miR-4715-5p-RAC1/PAK1 axis plays an important role in the progression of lung cancer. LCAT1 is an oncogene that is significantly upregulated in lung cancer tissues and associated with poor prognosis. Yes LCAT1 knockdown caused growth arrest and cell invasion in lung cancer cells in vitro, and inhibited tumorigenesis and metastasis in the mouse xenografts. 31779616 LCAL1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Regulation[AMPK/mTOR/S6K axis ] RNA Pull-Down//Western Blot//qRT-PCR//MTT//Colony Formation Assay Recently, lung cancer-associated lncRNA 1 (LCAL1) has been identified to be overexpressed in lung cancer tissues. Our study revealed that overexpressed LCAL1 may induce aerobic glycolysis in lung cancer cells through AMPK/HIF1α axis, enhance protein synthesis through AMPK/mTOR/S6K axis, and suppress autophagic cell death through AMPK/ULK1 pathway. Yes while inhibiting LCAL1 expression has shown potential to inhibiting lung cancer growth. 30741368 LBX2‑AS1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cells Regulation(miR‑491‑5p/S100A11 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//ELISA//Transwell Assay The results showed that LBX2‑AS1 was upregulated both in colorectal cancer tissues and cells, which was distributed in the cytoplasm and nucleus of colorectal cancer cells. Clinically, high LBX2‑AS1 expression could be an independent prognostic factor for colorectal cancer. Furthermore, relative operating characteristic curve analysis showed that LBX2‑AS1 was a sensitive diagnostic marker for colorectal cancer. Highly expressed ELK1, as a transcription factor, could bind to the two conserved sites in the promoter region of LBX2‑AS1, thereby activating the transcription of LBX2‑AS1. Silencing LBX2‑AS1 markedly inhibited proliferative, migratory and invasive abilities of colorectal cancer cells. miR‑491‑5p expression was downregulated, while S100A11 expression was upregulated in colorectal cancer tissues and cells. Dual‑luciferase reporter assays confirmed that LBX2‑AS1 could block S100A11 degradation via competitively binding to miR‑491‑5p. Furthermore, LBX2‑AS1 overexpression could notably reverse the inhibitory effect of miR‑491‑5p on proliferation and invasion of colorectal cancer cells. Taken together, LBX2‑AS1 induced by transcription factor ELK1 may facilitate colorectal cancer cell proliferation and invasion via regulation of the miR‑491‑5p/S100A11 axis. Thus, LBX2‑AS1 could be an underlying prognostic and diagnostic marker for colorectal cancer. Clinically, high LBX2‑AS1 expression could be an independent prognostic factor for colorectal cancer. Furthermore, relative operating characteristic curve analysis showed that LBX2‑AS1 was a sensitive diagnostic marker for colorectal cancer. Yes Dual‑luciferase reporter assays confirmed that LBX2‑AS1 could block S100A11 degradation via competitively binding to miR‑491‑5p. 34080639 LBX2-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[LBX2-AS1/miR-4766-5p/CXCL5] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Transwell Assay LBX2-AS1 was up-regulated in GC tissues and cells, and its knockdown suppressed proliferation, migration and invasion of GC cells. The LBX2-AS1/miR-4766-5p/CXCL5 regulatory axis provides a theoretical basis for the research on lncRNA-directed therapeutics in GC. Yes LBX2-AS1 was up-regulated in GC tissues and cells, and its knockdown suppressed proliferation, migration and invasion of GC cells. 33061849 LBX2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation[Notch signaling] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//EdU Staining//Transwell Assay We found that LBX2-AS1 was highly expressed in NSCLC tissues and cell lines.Mechanistic studies revealed that the suppression of LBX2-AS1 resulted in the reduced expressions of Notch1, p21, and Hes1, suggesting that LBX2-AS1 might promote the activation of the Notch pathway. The increased levels of LBX2-AS1 were observed to be positively correlated with TNM stage, histological grade, and lymph node metastasis. Furthermore, the Kaplan-Meier survival curves indicated that patients with higher expressions of LBX2-AS1 had unfavorable overall survival. Yes Lost-of-functions assays revealed that the knockdown of LBX2-AS1 in H1299 and A549 cells inhibited cell proliferation, migration, and invasion. 31539129 LBX2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction[ZEB1 and ZEB2] qRT-PCR Furtherly, dysregulation of LBX2-AS1 was identified in ESCC tissues with metastasis. Collectively, our data showed that ZEB1-induced upregulation of LBX2-AS1 promoted cell migration and EMT process in ESCC via enhancing the stability of ZEB1 and ZEB2. Yes Loss-of function assays were conducted and revealed that LBX2-AS1 knockdown suppressed ESCC cell migration and epithelial-mesenchymal transition (EMT). 30824187 LBX2-AS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Interaction(miR-627-5p/RAC1/PI3K/AKT pathway) Western Blot//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//H&E Staining//IHC//Transwell Assay . The results illustrated that LBX2-AS1 level was substantially increased in colon cancer tissues and was obviously correlated with the tumor volume and early distant metastasis of patients. On the other hand, miR-627-5p, down-regulated in colon cancer tissues, was negatively associated with LBX2-AS1 expression. Functional experiments showed that miR-627-5p suppressed colon cancer growth. Mechanistically, LBX2-AS1, as an endogenous competitive RNA, targeted miR-627-5p and restrained its expression, while miR-627-5p targeted and negatively regulated the RAC1/PI3K/AKT axis. Yes Besides, overexpression of LBX2-AS1 remarkably boosted growth, proliferation, and metastasis and restrained apoptosis in colon cancer cells, whereas LBX2-AS1 knockdown produced the opposite effect. 35816228 LBX2-AS1 LncRNA Homo sapiens Ovarian Neoplasms ovarian tissues regulation[inhibiting miR-455-5p and miR-491-5p] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//Colony Formation Assay Ovarian cancer tissue specimens showed significant higher LBX2-AS1 expression levels that non-cancerous counterparts.This lncRNA increased the cell growth, survival, migration, invasion and tumour formation of ovarian cancer cells by inhibiting miR-455-5p and miR-491-5p, thus liberating the expression of E2F2 cancer-promoting gene. High expression level of LBX2-AS1 was significantly associated with reduced overall survival of patients. Yes LBX2-AS1 knockdown significantly down-regulated the cell growth, colony formation, migration, invasion and tumour formation capacity of ovarian cancer cells and increased their apoptosis in vitro. 33342041 LBX2-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines regulation[miR-4784/KDM5C axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//ChIP LBX2-AS1 expression was markedly increased in OC tissues and cell lines. This study proved that ELK1 activated-LBX2-AS1 aggravated the progression of OC by targeting the miR-4784/KDM5C axis, suggesting that LBX2-AS2 may be a promising diagnostic biomarker of OC. Yes Functionally, LBX2-AS1 silencing inhibited cell proliferation, migration and stemness but facilitated cell apoptosis in OC. Moreover, depletion of LBX2-AS1 suppressed tumor growth of OC in vivo. 33099720 LBX2-AS1 LncRNA Homo sapiens Glioma clinical glioma tissues Interaction(Akt/GSK3β pathway) Western Blot//Migration Assay//qRT-PCR//RNA-seq//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay In this study, using online-available datasets combined with clinical glioma tissues collected, we found that LBX2-AS1 was significantly increased and negatively correlated with prognosis in glioma. RNA sequencing and western blot analysis confirmed that LBX2-AS1 regulates the Akt/GSK3β pathway. In this study, using online-available datasets combined with clinical glioma tissues collected, we found that LBX2-AS1 was significantly increased and negatively correlated with prognosis in glioma. Yes In vitro functional assays such as CCK-8, Annexin V, transwell assay, and western blot analysis showed that silencing of LBX2-AS1 suppressed the proliferation, migration, and invasion of glioma cells and increased apoptosis. 33637977 LBX2-AS1 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissue Regulation(FSTL3 /TF RARα) In Vivo Experiment//ChIP//Western Blot//Transfection//Wound Healing Assay//CCK8//FISH//qRT-PCR//RIP//Luciferase Report Assay//H&E Staining//IHC//Bioinformatics Analysis//Transwell Assay Bioinformatics analysis indicated that lncRNA LBX2-AS1, RARα, FSTL3 were remarkably fostered in thyroid cancer tissue, and LBX2-AS1 was evidently correlated with clinical features. The LncMAP triplet prediction showed that LBX2-AS1 recruited TF RARα to modulate FSTL3. RIP assay confirmed that LBX2-AS1 was prominently enriched on RARα. The integrative results demonstrated that LBX2-AS1 activated FSTL3 by binding to TF RARα to hasten proliferation, migration and invasion of thyroid cancer. Bioinformatics analysis indicated that lncRNA LBX2-AS1, RARα, FSTL3 were remarkably fostered in thyroid cancer tissue, and LBX2-AS1 was evidently correlated with clinical features. Yes The integrative results demonstrated that LBX2-AS1 activated FSTL3 by binding to TF RARα to hasten proliferation, migration and invasion of thyroid cancer. 34858481 LBX2-AS1 LncRNA Homo sapiens Multiple Myeloma MM patients Regulation(LBX2 ) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay Circulating LBX2-AS1 was up-regulated in MM patients and positively correlated to LBX2 expression. . Its up-regulation was also found in MM cells and primarily distributed in cytoplasm. Overexpressing LBX2-AS1 markedly strengthened LBX2 expression by increasing its mRNA stability. Rescue assays showed that silencing LBX2-AS1 distinctly weakened the pcDNA3.1-LBX2-induced increase in proliferation and decrease in apoptosis for MM cells. Yes LBX2-AS1 knockdown distinctly weakened proliferative ability and induced apoptosis in MM cells. Silencing LBX2-AS1 markedly weakened tumor growth. 34552959 LATS2-AS1-001 LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[LATS2/YAP1 signaling pathway,EZH2] qRT-PCR//RIP Decreased expression levels of LATS2-AS1-001 and LATS2 were confirmed in 357 GC tissues compared with the normal mucosa. Mechanistically, overexpressing LATS2-AS1-001 upregulated LATS2 and induced YAP1 phosphorylation via binding to EZH2. Yes Moreover, ectopic expression of LATS2-AS1-001 decreased cell viability, induced G0/G1 phase arrest, and inhibited cell migration and invasion in GC cells. 32514249 LASTR LncRNA Homo sapiens Lung Neoplasms lung cancer cell lines Interaction(miR-137/TGFA/PI3K/AKT axis) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay qRT-PCR results showed that LASTR was highly expressed in lung cancer cell lines relative to the expression level in normal lung epithelial cell line.Analysis of the downstream mechanism of LASTR demonstrated that LASTR exerts the oncogene effect through the miR-137/TGFA axis. GSEA results indicated that LASTR exhibits its activity by activating the PI3K/AKT signaling pathway, which was validated by western blotting assay. Yes Cell phenotype experiments indicated that knockdown of LASTR significantly inhibited proliferation and metastatic ability of lung cancer cells. 35281858 LARRPM LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(TET1 /LINC00240 and CSF1) In Vivo Experiment//qPCR//Invasion Assay//Migration Assay The lncRNA LARRPM was expressed at low levels in LUAD tissues and cells. Mechanistically, LARRPM bound and recruited DNA demethylase TET1 to the promoter of its anti-sense strand gene LINC00240, leading to a decrease in DNA methylation level of the LINC00240 promoter and transcriptional activation of LINC00240. Functional rescue assays suggested that the lncRNA LINC00240 was responsible for the roles of LARRPM in the malignant behavior of LUAD cells. LARRPM decreased the binding of TET1 to the CSF1 promoter, resulting in increased DNA methylation of the CSF1 promoter and transcriptional repression of CSF1, which is responsible for the roles of LARRPM in macrophage M2 polarization and infiltration. The low expression of LARRPM was correlated with advanced stage and poor survival of patients with LUAD. Yes Functional experiments revealed that LARRPM suppressed LUAD cell proliferation, migration and invasion, and promoted apoptosis. LARRPM also repressed macrophage M2 polarization and infiltration. Taken together, LARRPM significantly restricted LUAD progression in vivo. 36221069 LARP4 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell lines (including A549, NCI-H1650, NCI-H1299, and HCC827 cells) Interaction( miR-367) Transfection//qPCR//PCR//Invasion Assay//IF CircRNA LARP4 was decreased in NSCLC cell lines (including A549, NCI-H1650, NCI-H1299, and HCC827 cells) compared to BEAS-2B cells. Yes In NCI-H1650 cells, circRNA LARP4 overexpression inhibited cell proliferation, migration, and invasion, while promoting apoptosis. In A549 cells, circRNA LARP4 knockdown increased cell proliferation, migration, and invasion, while decreasing apoptosis. Moreover, miR-367 was decreased by the overexpression of circRNA LARP4, but increased by the knockdown of circRNA LARP4; and further luciferase reporter assay revealed that circRNA LARP4 could directly bind to miR-367. 34527128 LARP4 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[SMAD7] qRT-PCR Compared with adjacent tissues, circ LARP4 was lowly expressed in NSCLC tissues. Circ LARP4 could suppress the metastasis of NSCLC by up-regulating SMAD7. Meanwhile, expression of circ LARP4 was associated with the prognosis of NSCLC patients. Yes Downregulated circ LARP4 was found in NSCLC cell lines as well. The migration and invasion abilities of NSCLC cells were significantly inhibited via overexpression of circ LARP4. 32141555 LCAT3 LncRNA Homo sapiens Lung Neoplasms lung adenocarcinomas Interaction(FUBP1 /c-MYC) CCK8//qRT-PCR//RNA-seq LCAT3 was found to be up-regulated in lung adenocarcinomas (LUAD), and its over-expression was associated with the poor prognosis of LUAD patients. LCAT3 upregulation is attributable to N6-methyladenosine (m6A) modification mediated by methyltransferase like 3 (METTL3), leading to LCAT3 stabilization. Mechanistically, LCAT3 recruited Far Upstream Element Binding Protein 1 (FUBP1) to the MYC far-upstream element (FUSE) sequence, thereby activating MYC transcription to promote proliferation, survival, invasion and metastasis of lung cancer cells. Yes Biologically, loss-of-function assays revealed that LCAT3 knockdown significantly suppressed lung cancer cell proliferation, migration and invasion in vitro, and inhibited tumor growth and metastasis in vivo. LCAT3 knockdown induced cell cycle arrest at the G1 phase. 34274028 LDC1P LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,blood Interaction[Wnt/β-catenin signalling pathway] IHC//Western Blot//Wound Healing Assay//qRT-PCR//Colony Formation Assay//Transwell Assay Here, we verified that LINC01225 was up-regulated in tumour tissues and plasma of GC.In conclusion, LINC01225 promotes the progression of GC through Wnt/β-catenin signalling pathway, and it may serve as a potential target or strategy for diagnosis or treatment of GC. Analysis with clinicopathological information suggested that up-regulation of LINC01225 was associated with advanced disease and poorer overall survival. Yes In addition, knockdown of LINC01225 led to retardation of cell proliferation, invasion and migration, and overexpression of LINC01225 showed the opposite effects. 31460694 LAMC2-1:1 LncRNA Homo sapiens Colonic Neoplasms COAD cell lines Interaction(miR-216a-3p/HMGB3) qRT-PCR//Transfection//Luciferase Report Assay In this study, we found that the lnc-LAMC2-1:1 SNP rs2147578 was upregulated in COAD cell lines.Furthermore, lnc-LAMC2-1:1 SNP rs2147578 promoted colon cancer migration, invasion, and proliferation. Interestingly, lnc-LAMC2-1:1 SNP rs2147578 positively regulated HMGB3 expression via miR-216a-3p in colon cancer cells. Yes Furthermore, lnc-LAMC2-1:1 SNP rs2147578 promoted colon cancer migration, invasion, and proliferation. Interestingly, lnc-LAMC2-1:1 SNP rs2147578 positively regulated HMGB3 expression via miR-216a-3p in colon cancer cells. 36582685 LDLRAD4-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC specimens and cell lines regulation[ LDLRAD4-AS1-LDLRAD4-Snail regulatory axis ] Western Blot//Wound Healing Assay//qRT-PCR//FISH//Transwell Assay In this study, we observed that lncRNA LDLRAD4-AS1 was located in the nucleus of CRC cells and that lncRNA LDLRAD4-AS1 was upregulated in most CRC specimens and cell lines.Our results demonstrated a previously unrecognized LDLRAD4-AS1-LDLRAD4-Snail regulatory axis involved in epigenetic and posttranscriptional regulation that contributes to CRC progression and metastasis. Overexpression of lncRNA LDLRAD4-AS1 was correlated with poor prognosis in CRC patients. Yes LncRNA LDLRAD4-AS1 upregulation enhanced the migration and invasion of CRC cells in vitro and facilitated CRC metastasis in vivo. 32111819 LEMD1-AS1 LncRNA Homo sapiens Osteoarthritis chondrocyte Interaction(miR-944/PGAP1) RNA Pull-Down//Western Blot//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//ELISA//EdU Staining LEMD1-AS1 bound to miR-944 and regulated its expression, and PGAP1 presented as a direct target gene of miR-944, which was confirmed by a dual-luciferase reporter assay. Inhibition of PGAP1 partially restored the effects of LEMD1-AS1/miR-944 on the proliferation, cell apoptosis, cell cycle distribution and inflammatory responses of LPS-treated chondrocytes. To conclude, the LEMD1-AS1/miR-944/PGAP1 axis may be a novel therapeutic candidate to target in OA treatment. Yes Over-expression of LEMD1-AS1 or down-regulation of miR-944 significantly promoted viability, proliferation and inhibited cell apoptosis, cell cycle arrest and inflammatory responses of chondrocytes treated with LPS by CCK-8, EdU, flow cytometry and an ELISA assay. 35686740 LEMD1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(LEMD1/ PI3K-AKT signaling pathway) CCK8//qRT-PCR//Wound Healing Assay//Western Blot In addition, both LEMD1-AS1 and its cognate LEMD1 were up-regulated in metastatic OSCC compared to nonmetastatic OSCC. Mechanistically, LEMD1-AS1 stabilized LEMD1 and increased its mRNA and protein levels, and consequently activated the PI3K-AKT signaling pathway to facilitate OSCC metastasis. Yes Gain-of-function, loss-of-function, and rescue experiments indicated that LEMD1-AS1 upregulated LEMD1 to increase OSCC migration and invasion in vitro and in vivo. 35983249 LEISA LncRNA Homo sapiens Adenocarcinoma of Lung LAD tissues and cells Interaction(STAT3 and IL-6 promoter) In Vivo Experiment//RNA Pull-Down//Northern Blot//Western Blot//qRT-PCR//ChIP Our data showed that LEISA was highly expressed in, and correlated with the clinical progression and prognosis of LAD.Mechanistically, we demonstrated that LEISA recruited STAT3 to bind the promoter of IL-6 and upregulated IL-6 expression. Yes Ectopic expression of LEISA promoted the proliferation and suppressed apoptosis of LAD cells in vitro and in vivo. 33859372 LEF-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[ LEF-AS1/miR-505/KIF3B axis] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining//Transwell Assay The expression of LEF-AS1 in CRC tissue specimens was found to be markedly higher than that in normal colon tissues. However, the down-regulation of LEF-AS1 reduces the proliferation rate and suppresses the invasiveness and metastasis of CRC cells through the LEF-AS1/miR-505/KIF3B axis. Yes After transfection with LEF-AS1 siRNA, the cell viability, as well as cell migration and invasion capacities, were both attenuated. 31773695 LEF1-AS1 LncRNA Homo sapiens Stomach Neoplasms cell lines Interaction(miR-5100/DEK/AMPK-mTOR Axis) qRT-PCR//IHC//Luciferase Report Assay//Western Blot Studies have shown that miR-5100 acts by targeting the 3'UTR of DEK, and LEF1-AS1 regulates the expression of miR-5100 by sponging with mIR-5100. In conclusion, our results found that LEF1-AS1 and miR-5100 sponge function, and the miR-5100/DEK/AMPK/mTOR axis regulates autophagy and apoptosis in gastric cancer cells. Yes In addition, miR-5100 inhibits autophagy and promotes apoptosis in GC cells while LEF1-AS1 had the opposite effect. 35563178 LEF1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-489/DIAPH1 axis] qRT-PCR We firstly showed that LEF1-AS1 expression was upregulated in human CRC tissues and cell lines.Mechanically, LEF1-AS1 functioned as competing endogenous RNA (ceRNA) for miR-489 to positively recover DIAPH1, thus playing an oncogenic role in CRC pathogenesis. Clinical study revealed that high LEF1-AS1 expression was positively associated with histological grade, lymph nodes metastasis, and decreased survivals of CRC patients. Yes Functionally, down-regulation of LEF1-AS1 using si-LEF1-AS1 decreased cell growth, migration and invasion, as well as increased apoptosis in CRC cells. 32248974 LEF1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation(Wnt/β-catenin/LEF1 pathway) CCK8//qRT-PCR//Western Blot Here, we identify that LEF1-AS1 and LEF1 are higher in CRC tissues than that in adjacent tissues, as well as upregulated in CRC cell lines than that in normal colorectal cells. Altered levels of LEF1-AS1 modulate LEF1 expression, while altered LEF1 could not regulate LEF1-AS1. LEF1-AS1 recruits MLL1 to the promoter region of LEF1, induces H3K4me3 methylation modification and mediates LEF1 transcription. FUT8 is a direct target of transcription factor LEF1, which regulates FUT8 level. Altered FUT8 also regulates the core fucosylation of CRC cells, and LEF1-AS1 mediates FUT8 level through activation of Wnt/β-catenin/LEF1 pathway, thereby resulting in β-catenin nuclear translocation. Yes In addition, LEF1-AS1 mediates the proliferation, migration and invasion of CRC cells in vitro. LEF1-AS1 silence hinders the tumorigenesis, liver and lung metastasis of SW620 cells in vivo, while overexpressed FUT8 abolishes the suppressive impact of LEF1-AS1 repression on the biological behavior of SW620 cells. 34021424 LEF1-AS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer patients regulation[miR-30-5p/SOX9 Axis] RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Transwell Assay We found that LEF1-AS1 was upregulated in colon cancer patients and correlated with poor overall survival and recurrent-free survival. Our results indicated that LEF1-AS1 promoted migration, invasion and metastasis of colon cancer cells partially through miR-30-5p/SOX9 axis. We found that LEF1-AS1 was upregulated in colon cancer patients and correlated with poor overall survival and recurrent-free survival. Yes Besides, enforced expression of LEF1-AS1 in HT29 and T84 cells promoted migration, invasion, anchorage-independent growth, tumor xenograft formation and lung metastasis, while knockdown of LEF1-AS1 in COLO320 cells suppressed cell migration, invasion, anchorage-independent growth and tumor xenograft formation. 32308428 LEF1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[microRNA-136-5p/WNK1] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//Transwell Assay HCC tissues and cells contained high lncRNA LEF1-AS1 expression.Association of lncRNA LEF1-AS1 with WNK1 blocked the inhibitory effect of miR-136-5p on WNK1, which was confirmed by in vivo experiments. Yes LncRNA LEF1-AS1 upregulation triggered markedly increased HCC cell proliferation, migration, and invasion and human umbilical vein endothelial cell angiogenesis. In vivo silencing lncRNA LEF1-AS1 resulted in reduced tumor cell vitality and matrix metalloproteinase-9 and the vascular endothelial growth factor expression. 32068261 LEF1-AS1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues interaction[miR-1285-3p] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We showed that LEF1-AS1 expression was upregulated in ovarian cancer tissues compared with normal tissues. Mechanistically, LEF1-AS1 exerted its oncogenic functions through interacting with miR-1285-3p to inhibit miRNA activity. Besides, LEF1-AS1 level was positively correlated with lymph node metastasis and advanced stage. Yes Moreover, LEF1-AS1 knockdown suppressed ovarian cancer cell proliferation, migration and invasion. 32099465 LEF1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Regulation[Hippo signaling pathway] IHC//Western Blot//Co-IP//qRT-PCR//RIP//MTT//Cell Cycle Assay//Colony Formation Assay//Transwell Assay In this study, we unveiled that LEF1-AS1 markedly increased in oral squamous cell carcinoma (OSCC) tissues and cell lines. In a word, we concluded that LEF1-AS1 served an oncogenic part in OSCC through suppressing Hippo signaling pathway by interacting with LATS1, suggesting the therapeutic and prognostic potential of LEF1-AS1 in OSCC. Yes Functionally, LEF1-AS1 knockdown inhibited cell survival, proliferation and migration, whereas enhanced cell apoptosis and induced G0/G1 cell cycle arrest in vitro. 30983488 LEF1-AS1 LncRNA Homo sapiens Glioma glioma tissues and cell lines regulation[LEF1-AS1/miR-489-3p/HIGD1A axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down Hence, in this study, we tested that LEF1-AS1 expression was significantly upregulated in glioma tissues and cell lines.In summary, our studies corroborated the regulatory mechanism of LEF1-AS1/miR-489-3p/HIGD1A axis in glioma, suggesting that targeting LEF1-AS1 might be a promising method for glioma therapy in the future. Yes Besides, knockdown of LEF1-AS1 repressed cell proliferation while activated apoptosis in glioma cells in vitro, and also suppressed tumor growth in vivo. 32826866 LEF1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues Regulation[miR-489/SOX4 Axis ] Western Blot//Flow Cytometry//qRT-PCR//CCK8//RIP//Luciferase Report Assay//Transwell Assay In the present study, we found that LEF1-AS1 was markedly upregulated in lung cancer tissues and could promote NSCLC cell proliferation and migration in vivo and in vitro. LEF1-AS1 could bind with miR-489 and further negatively regulate miR-489 to promote SRY-related HMG box transcription factor 4 (SOX4) expression. In conclusion, these data suggested that LEF1-AS1 promoted NSCLC tumorigenesis dependent on the miR-489-SOX4 axis and implicated the potential application of LEF1-AS1 for the prognosis and treatment of NSCLC. Yes In the present study, we found that LEF1-AS1 was markedly upregulated in lung cancer tissues and could promote NSCLC cell proliferation and migration in vivo and in vitro. 31386568 LEF1-AS1 LncRNA Homo sapiens Retinoblastoma retinoblastoma tissues and cell lines regulation[Wnt/β-catenin pathway] qRT-PCR In our study, LEF1-AS1 expression was increased in retinoblastoma tissues and cell lines compared with paired adjacent normal tissues and the retinal pigment epithelial cell line, respectively.The in vitro assays suggested that silencing of LEF1-AS1 suppressed retinoblastoma cell proliferation, migration, and invasion through regulating the Wnt/β-catenin pathway. High LEF1-AS1 expression predicted poor disease-free survival in patients with retinoblastoma. Yes The in vitro assays suggested that silencing of LEF1-AS1 suppressed retinoblastoma cell proliferation, migration, and invasion through regulating the Wnt/β-catenin pathway. 31990064 LEF1-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute cell lines Expression[lower expressed] qRT-PCR We show that LEF1-AS1 is highly expressed in normal hematopoietic stem cells but barely detectable in myeloid malignant cell lines. Yes Artificial LEF1-AS1 over-expression inhibited proliferation in HL60 and led to an upregulation of tumor suppressors p21 and p27, and reduced ERK1/2 activation. 30770626 LEF1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues and cells Interaction(miR-221-5p/GJA1 Axis) Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis In the current manuscript, we revealed the elevated expression of long noncoding RNA (lncRNA) LEF1-AS1 in HNSCC which was associated with the poor prognosis by bioinformatic analysis.Most importantly, we illustrated that LEF1-AS1 played as a competitive endogenous RNA (ceRNA) via sponging miR-221-5p and thereby positively regulated gap junction protein alpha 1 (GJA1) expression, thus aggravated tumor progression and EMT. In the current manuscript, we revealed the elevated expression of long noncoding RNA (lncRNA) LEF1-AS1 in HNSCC which was associated with the poor prognosis by bioinformatic analysis. Yes Moreover, we noticed that LEF1-AS1 dramatically accelerated the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) process in HSCC cell line FaDu. 35371339 LEF1-AS1 LncRNA Homo sapiens Prostatic Neoplasms AIPC tissues regulation[Wnt/β-catenin pathway] RIP//qRT-PCR//Transwell Assay//EdU Staining//ChIP The next-generation sequencing results showed that LEF1-AS1 is significantly overexpressed in AIPC. Furthermore, our RT-qPCR assay data showed that LEF1-AS1 is overexpressed in AIPC tissues. Yes Functional experiments showed that LEF1-AS1 promotes the proliferation, migration, invasion and angiogenic ability of AIPC cells in vitro and tumour growth in vivo by recruiting the transcription factor C-myb to the promoter of FZD2, inducing its transcription. 33292271 LEF1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-221/PTEN Signaling] Cell Proliferation Assay//qRT-PCR//Cell Apoptosis Assay We found that LEF1-AS1 was upregulated in NSCLC patients. LEF1-AS1 may promote the proliferation and induce apoptosis of NSCLC cells by regulating miR-221/PTEN signaling. Yes Overexpression of LEF1-AS1 and miR-221 promoted cancer cell proliferation and inhibited apoptosis. 32547220 LEF1-AS1 LncRNA Homo sapiens Spinal Cord Injuries LPS-treated SCI and microglial cells Interaction(miR-222-5p/RAMP3 ) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay We revealed that LncRNA LEF1-AS1 was distinctly upregulated, whereas miR-222-5p was significantly downregulated in LPS-treated SCI and microglial cells. Mechanistically, LEF1-AS1 served as a competitive endogenous RNA (ceRNA) by sponging miR-222-5p, targeting RAMP3. RAMP3 overexpression attenuated LEF1-AS1-mediated protective effects on LPS-mediated microglial cells from apoptosis and inflammation. Yes However, LEF1-AS1 knockdown enhanced cell viability, inhibited apoptosis, as well as inflammation of LPS-mediated microglial cells. On the contrary, miR-222-5p upregulation decreased cell viability, promoted apoptosis, and inflammation of microglial cells. 33407665 LAMTOR5-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction(miR-210-3p) Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay LAMTOR5-AS1 decreased in cervical cancer tissues, while miR-210-3p expression increased. In the study of cervical cancer cells, it was found that the LAMTOR5-AS1 sponge miR-210-3p was associated with the malignant progression of cervical cancer. Yes Overexpression of LAMTOR5-AS1 could effectively inhibit the development of cervical cancer cells and might be chosen as a prognostic biomarker of cervical cancer. 36173004 LALTOP LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(Top2α) Bioinformatics Analysis LALTOP expression is increased in NSCLC tissues and cell lines. RNA-RNA interaction assay showed that LALTOP bound and stabilized topoisomerase II alpha (Top2α) mRNA. Positive correlation can be found between LALTOP and Top2α mRNA expressions in clinical specimens. Yes Moreover, LALTOP strongly promoted proliferation and migration of A549 and H1793 cells. 34438347 KCNQ1OT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines regulation[S1PR1,miR-149] RNA Pull-Down//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay KCNQ1OT1 and S1PR1 were significantly increased, but miR-149 was decreased in HCC cells.Luciferase reporter assays and RNA pull-down assays revealed that KCNQ1OT1 directly targeted miR-149. In addition, miR-149 bound to the 3'-UTR of S1PR1. Yes Knockdown of KCNQ1OT1 or overexpression of miR-149 inhibited the invasion and migration of HCC cells. In vivo assays showed that KCNQ1OT1 knockdown suppressed tumour growth. 32753631 KILH LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(KRT19/β-catenin) qRT-PCR Here, we identify a novel lncRNA Linc-KILH (KRT19 interacting long noncoding RNA in hepatocellular carcinoma), which is significantly up-regulated in HCC tissues and positively correlated with larger tumor size, severer microvascular invasion, more intrahepatic metastasis and decreased survival of HCC patients. Mechanistically, Linc-KILH interacts with KRT19 and then inhibits the phosphorylation of KRT19 on Ser35, thereby, enhancing the translocation of KRT19 from cytoplasm to membrane in KRT19 positive HCC cells. Additionally, we validated that KRT19 interacts with β-catenin but not RAC1 in HCC cells. Linc-KILH enhanced the interaction between β-catenin and KRT19 in cytoplasm and promoted the nuclear translocation of β-catenin in HCC cells. Furthermore, Linc-KILH could enhance the promoting function of KRT19 on Notch1 signaling with the existence of KRT19 in HCC cells. Here, we identify a novel lncRNA Linc-KILH (KRT19 interacting long noncoding RNA in hepatocellular carcinoma), which is significantly up-regulated in HCC tissues and positively correlated with larger tumor size, severer microvascular invasion, more intrahepatic metastasis and decreased survival of HCC patients. Yes Silence of Linc-KILH remarkably inhibited the proliferation and metastasis abilities of KRT19-positive HCC cells in vitro and in vivo. 33767587 KIF4A CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(MicroRNA-144-3p/EZH2 Axis) Western Blot//Transfection//qPCR//IF//MTT//PCR//Transwell Assay Our findings demonstrated that circKIF4A was highly expressed in both GC tissues and cell lines, and high intratumoral circKIF4A expression predicted a poor prognosis in GC patients. Mechanistically, we found that circKIF4A was mainly located in the cytoplasm, could directly interact with microRNA- (miR-) 144-3p, and functions as a miRNA sponge to regulate EZH2 expression in GC cells. miR-144-3p inhibition or EZH2 restoration largely blocked the effects of circKIF4A knockdown on the malignant behaviors of GC cells. Our findings demonstrated that circKIF4A was highly expressed in both GC tissues and cell lines, and high intratumoral circKIF4A expression predicted a poor prognosis in GC patients. Yes In vitro gain- and loss-of-function assays indicated that circKIF4A knockdown suppressed the proliferation, migration, invasion, and EMT of GC cells, while these malignant behaviors were enhanced by circKIF4A overexpression. 35466313 KDM7A-DT LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-450a-2-3p-PRAF2 axis] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay The expression levels of JHDM1D-AS1 and miR-450a-2-3p in GC tissues and cell lines were higher and lower as compared to those in the corresponding normal controls, respectively. Moreover, high levels of JHDM1D-AS1 were closely related with metastasis and the GC TNM stage. Yes Functionally, JHDM1D-AS1 depletion caused an obvious reduction in cell proliferation and invasion both in vitro and in vivo, while the addition of miR-450a-2-3p inhibitor could nullify these effects. 33245963 KDM7A-DT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor samples and adjacent normal tissues,cell lines (A549, H1299, HCC827, H358, and H1975) Interaction[DHX15 ] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Cell Proliferation Assay//Invasion Assay//Transwell Assay The expression level of JHDM1D-AS1 was significantly greater in NSCLC specimens than that in adjacent normal lung tissues.In addition, multiple NSCLC cell lines had an increased level of JHDM1D-AS1 compared to BEAS-2B bronchial epithelial cell lines.Collectively, the interaction between JHDM1D-AS1 and DHX15 accounts for NSCLC growth and metastasis. High JHDM1D-AS1 expression is significantly correlated with advanced tumor, node, and metastasis (TNM) stage and lymph node metastasis. JHDM1D-AS1 expression serves as an independent prognostic factor for overall survival of patients with NSCLC. Yes Functionally, JHDM1D-AS1 knockdown inhibits NSCLC cell aggressiveness both in vitro and in vivo, which is rescued by ectopic expression of JHDM1D-AS1. 31739208 KDM4A-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-411-5p/KPNA2/AKT pathway) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Transfection//qRT-PCR//FISH//IF//RIP//Luciferase Report Assay//Cell Proliferation Assay//IHC//Transwell Assay Here we identified a novel lncRNA KDM4A-AS1, which was aberrantly overexpressed in HCC tissues, associated with unfavorable clinical features and poor prognosis of patients. Mechanistically, KDM4A-AS1 was inversely modulated by miR-411-5p at the post-transcriptional level and facilitated Karyopherin α2 (KPNA2) expression by competitively binding miR-411-5p, thereby activating the AKT pathway. Here we identified a novel lncRNA KDM4A-AS1, which was aberrantly overexpressed in HCC tissues, associated with unfavorable clinical features and poor prognosis of patients. Yes KDM4A-AS1 promoted HCC cell proliferation, migration, and invasion in vitro and contributed to HCC growth and lung metastasis in vivo. 34903711 KDM1A LncRNA Homo sapiens Glioblastoma GBM cell lines Regulation(upregulating H3K4me2 and downregulating H3K27me3) In Vivo Experiment//Western Blot//H&E Staining//Flow Cytometry//qRT-PCR//IF//Microarray//Cell Proliferation Assay//IHC//ChIP we found that the combination of AQB and GSK-LSD1 showed a powerful effect of inhibiting cell cycle processes by targeting CDKN1A, whereas apoptosis promoting effects of combination therapy were mediated by BBC3 in vitro. ChIP assays revealed that GSK-LSD1 and AQB regulate P21 and PUMA, respectively via upregulating H3K4me2 and downregulating H3K27me3. Yes Microarray analysis showed that AQB and GSK-LSD1 regulate cell cycle processes and induces apoptosis in GBM cell lines. 34246782 KCNQ1OT1 LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[microRNA-9-LMX1A] Western Blot//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//EdU Staining//Transwell Assay KCNQ1OT1 putatively targets miR-9. Its level is downregulated in human GC tissues.Taken together, KCNQ1OT1 inhibits GC cell progression via regulating miR-9 and LMX1A expression. Yes Furthermore, KCNQ1OT1 overexpression inhibited GC cell survival, proliferation, migration and invasion, but inducing apoptosis activation. 31915311 KCNQ1OT1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells. Interaction(miR-145-5p/ARF6 axis) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay The expression levels of KCNQ1OT1 were markedly elevated in GC tissues and cells. The expression levels of miR-145-5p were significantly decreased in GC cells and correlated with the expression of KCNQ1OT1 in GC tumors. Moreover, KCNQ1OT1 directly binds with miR-145-5p, which is targeting ARF6. Yes Knockdown of KCNQ1OT1 inhibited GC tumor growth, reduced GC cell viability and colony formation, and induced GC cell apoptosis. 33682985 KCNQ1OT1 LncRNA Homo sapiens Breast Neoplasms breast cancer cell lines regulation[hsa-miR-107] CCK8//qRT-PCR//Luciferase Report Assay//Migration Assay We found that KCNQ1OT1 was significantly upregulated in breast cancer cell lines.Thus, loss of KCNQ1OT1 is associated with functional impairment in breast cancer cells, likely through inverse regulation of its sponging target, hsa-miR-107. Yes In lentiviral-transduced BT-549 and HCC1599 cells, KCNQ1OT1 knockdown impaired cancer cell functions, including in vitro proliferation and migration, and in vivo transplant growth. 32379482 KCNQ1OT1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-34a / Notch3 axis) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay KCNQ1OT1 expression was up-regulated in BC tissues and high levels were associated with poorer prognosis. Up-regulation of KCNQ1OT1 was shown to inhibit miR-34a which was associated with blocking the inhibitory effect of miR-34a on BC cell proliferation, migration and invasion. Notch3 was found to be a downstream target of miR-34a with KCNQ1OT1 markedly inducing Notch3 expression in BC. Evidence for KCNQ1OT1/miR-34a/Notch3 axis was further established in clinical BC samples. KCNQ1OT1 expression was up-regulated in BC tissues and high levels were associated with poorer prognosis. Yes ShRNA inhibition of KCNQ1OT1 expression in BC cell lines retarded proliferation, migration and invasion in vitro and tumor growth in vivo. 34993814 KCNQ1OT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[ miR-129-5p/JAG1 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay KCNQ1OT1 expression was significantly enhanced, while miR-129-5p expression was dramatically reduced in NSCLC tissues and cells. KCNQ1OT1 induced proliferation, migration and invasion of NSCLC cells by sponging miR-129-5p and regulating JAG1 expression, indicating that KCNQ1OT1 was a therapeutic target for NSCLC. Higher KCNQ1OT1 shortened overall survival and was positively associated with tumor stage and lymph node metastasis. Yes KCNQ1OT1 knockdown inhibited proliferation, migration and invasion of NSCLC cells. 32377169 KCNQ1OT1 LncRNA Homo sapiens Colorectal Neoplasms Regulation[miR-217/ZEB1 axis] RNA Pull-Down//ChIP//Western Blot//qRT-PCR//RIP//IF//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Based on the database analysis, KCNQ1OT1 was highly expressed in CRC samples and predicted the poor prognosis for CRC patients. In brief, our research findings revealed that ZEB1-induced upregulation of KCNQ1OT1 improved the proliferation, migration and EMT formation of CRC cells via regulation of miR-217/ZEB1 axis. Yes Functional experiments revealed that KCNQ1OT1 knockdown negatively affected the proliferation, migration and epithelial-mesenchymal transition (EMT) in CRC cells. 30794031 KCNQ1OT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[miR-329-3p/CTNND1 axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The levels of KCNQ1OT1 and CTNND1 were significantly increased in CRC tissues and cells.Our results indicated that KCNQ1OT1 could positively regulate CTNND1 expression by sponging miR-329-3p, thereby boosting the progression of CRC. Our findings provided the underlying therapy targets for CRC. Yes Knockdown of KCNQ1OT1 suppressed proliferation, migration, invasion, and induced apoptosis in CRC cells. 32760218 KCNQ1OT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[ PI3K/AKT pathway] qRT-PCR//Western Blot KCNQ1OT1 was overexpressed in CRC tissues and cell lines via RT-qPCR analysis. These results suggest that KCNQ1OT1 may act as an oncogene through the PI3K/AKT signaling pathway in CRC. GEPIA analysis demonstrated that high expression levels of KCNQ1OT1 in CRC tissues predicted a poor prognosis for patients with CRC. Yes Furthermore, the results from the cell viability assay, colony formation assay, wound healing assay, invasion assay and flow cytometric analysis demonstrated that KCNQ1OT1 knockdown significantly inhibited CRC cell proliferation, migration and invasiveness, and promoted CRC cell apoptosis, leading to cell cycle arrest. 32565985 KCNQ1OT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[HK2] qRT-PCR//RNA Pull-Down//Colony Formation Assay//RIP KCNQ1OT1 levels were significantly higher in CRC tissues than adjacent normal colorectal tissues (n=79). These findings show that KCNQ1OT1 promotes colorectal carcinogenesis by increasing aerobic glycolysis through HK2. Yes KCNQ1OT1-silenced CRC cells showed reduced proliferation, colony formation, extracellular acidification, and lactate and glucose secretion. 32564010 KCNQ1OT1 LncRNA Homo sapiens Colorectal Neoplasms tumor tissues and tumor cell-derived exosomes Interaction(MiR-30a-5p/USP22 ) CCK8//RIP//Flow Cytometry//Luciferase Report Assay//Microarray//IF The expression of lncRNA KCNQ1OT1 in tumor tissues and tumor cell-derived exosomes was significantly increased. Yes The tumor-promoting effect of lncRNA KCNQ1OT1 was through the autocrine effect of tumor cell-derived exosomes, which mediates the miR-30a-5p/USP22 pathway to regulate the ubiquitination of PD-L1 and inhibits CD8+ T-cell response, thereby promoting colorectal cancer development. 34350172 KCNQ1OT1 LncRNA Homo sapiens Colorectal Neoplasms Thirty matched CRC tissues and tumor-adjacent tissue Expression [highly expressed] Flow Cytometry//qRT-PCR//Western Blot Our results showed that the high expression of lncRNA KCNQ1OT1 was significantly related to poor overall survival across cancers, especially CRC. KCNQ1OT1 and CD155 showed significantly higher expression in CRC tissue than in normal tissue, and lncRNA KCNQ1OT1 expression was positively correlated with CD155 expression in CRC. Our results showed that the high expression of lncRNA KCNQ1OT1 was significantly related to poor overall survival across cancers, especially CRC. Interestingly, we found that COAD patients with high lncRNA KCNQ1OT1 expression and high CD8+ T cell infiltration levels had a worse prognosis than those with low lncRNA KCNQ1OT1 expression and high CD8+ T cell infiltration levels. Yes Finally, knockdown of lncRNA KCNQ1OT1 reduced CD155 expression in HCT116 and SW620 cells and enhanced the immune response in coculture with CD8+ T cells.  33994860 KCNQ1OT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-216b-5p/ZNF146 axis ) Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay KCNQ1OT1 expression was higher in CRC tissues and cell lines. KCNQ1OT1 accelerated the proliferation and motility of CRC cells through elevating ZNF146 expression via sponging miR-216b-5p. KCNQ1OT1/miR-216b-5p/ZNF146 axis might be underlying target for the diagnosis and treatment of CRC patients. Yes KCNQ1OT1 interference restrained the proliferation, migration and invasion of CRC cells. 33394291 KCNQ1OT1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Expression[Expression[highly expressed]-expression] qRT-PCR//Western Blot In this study, it is shown that the expression level of KCNQ1OT1 was increased in tumor, which indicated poor prognosis in colon cancer patients. Yes Using colon cancer cell lines HCT116 and SW480, it was demonstrated that knockdown of KCNQ1OT1 decreased the cell viability and increased the apoptosis rates Expression[up-expression]on L-OHP treatment. 31040703 KCNQ1OT1 LncRNA Homo sapiens Osteoarthritis cartilage tissues of post-traumatic OA patients (miR-126-5p/TRPS1 axis) qRT-PCR//RNA Pull-Down//Western Blot Relative expression of KCNQ1OT1 and TRPS1 was reduced, whereas miR-126-5p was augmented in cartilage tissues of post-traumatic OA patients compared to those of subjects without post-traumatic OA.miR-126-5p was the downstream target of KCNQ1OT1, and it could directly target TRPS1. There was an inverse correlation between KCNQ1OT1 and miR-126-5p or between miR-126-5p and TRPS1. Yes Increased KCNQ1OT1 or decreased miR-126-5p enhanced cell viability and migration, and repressed extracellular matrix (ECM) degradation in CHON-001 cells. 34108052 KIF9-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(RAI2/DNMT1) qRT-PCR We found that KIF9-AS1 expression was increased in HCC tissues. lncRNA KIF9-AS1-mediated RAI2 expression led to DNMT1 recruitment and regulated RAI2 DNA methylation. RAI2 overexpression inhibited the proliferation and migration and promoted the apoptosis of HCC cells. Yes KIF9-AS1 knockdown inhibited the proliferation and migration, and facilitated the apoptosis of HCC cells. KIF9-AS1 knockdown inhibited subcutaneous tumor formation in vivo. 36276278 KIZ LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells regulation[miR-653/CXCR5 axis] qRT-PCR In the present study, PLK1S1 was upregulated in RCC tissues and cells, and PLK1S1 expression was also significantly elevated in stage IV RCC tissues. In conclusion, the present study revealed that PLK1S1 promoted tumor progression and sorafenib resistance in RCC through regulation of the miR‑653/CXCR5 axis, which may offer a novel treatment strategy for patients with RCC. Kaplan?Meier analysis showed that patients with high PLK1S1 expression had a shorter overall survival time compared with those with low PLK1S1 expression. Yes Functional analyses demonstrated that a miR?653 inhibitor promoted short hairpin PLK1S1?attenuated cell proliferation, invasion and sorafenib resistance of RCC cells. 33000253 LALR1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[SNORD72 ] qRT-PCR//FISH In this study, we demonstrated that lncRNA-LALR1 was significantly upregulated in HCC tissues compared with adjacent tissues and high expression of lncRNA-LALR1 was associated with advanced TNM stage, poor differentiation, and distant metastasis. In conclusion, lncRNA-LALR1 is highly expressed in HCC and promotes tumor growth and invasion by upregulating SNORD72 to stabilize ID2 mRNA, implying that lncRNA-LALR1 might be a novel target for intervention of HCC. In this study, we demonstrated that lncRNA-LALR1 was significantly upregulated in HCC tissues compared with adjacent tissues and high expression of lncRNA-LALR1 was associated with advanced TNM stage, poor differentiation, and distant metastasis. Yes Knockdown of lncRNA-LALR1 obviously inhibited HCC cells growth and invasion in vivo and in vitro. 32160589 KLF3-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell line Interaction(miR-338-3p/MEF2C axis) qRT-PCR//RIP Elevated levels of KLF3-AS1 and MEF2C and reduced amounts of miR-338-3p were identified in OS. KLF3-AS1 targeted miR-338-3p, and miR-338-3p further targeted MEF2C. Inhibiting miR-338-3p inverted the cancer-suppressing effects of KLF3-AS1 silencing. Meanwhile, loss of MEF2C partially eliminated the effects brought about by miR-338-3p downregulation, namely the stimulation of cell growth and suppression of apoptosis. Yes Silencing KLF3-AS1 induced apoptosis and attenuated proliferation in vitro and repressed the tumor growth in vivo. 36250223 LA16c?313D11.11 LncRNA Homo sapiens Endometrial Neoplasms EC tissues regulation[microRNA-205-5p-PTEN axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Transwell Assay The expression levels of LA16c?313D11.11 and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in human EAH and EC tissues were significantly decreased, whereas the expression levels of miR?205?5p in EAH and EC tissues were significantly increased, compared with the normal endometrium tissues. Therefore, LA16c‑313D11.11 acts as an effective ceRNA associated with a microRNA‑205‑5p‑PTEN axis. Yes Additionally, the overexpression of LA16c?313D11.11 significantly reduced the invasion, migration and viability of HEC?1A and Ishikawa cells in vitro. 32319598 KTN1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[KTN1-AS1/miR-130a-5p/PDPK1 pathway ] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay We found that KTN1-AS1 expression was upregulated in NSCLC tissue and was positively associated with poor prognosis. Taken together, our results suggest that the KTN1-AS1/miR-130a-5p/PDPK1 pathway may be a potential therapeutic target for NSCLC. We found that KTN1-AS1 expression was upregulated in NSCLC tissue and was positively associated with poor prognosis. Yes KTN1-AS1 knockdown inhibited cell growth and proliferation, increased apoptosis, and modulated the expression of cell cycle- and apoptosis-related proteins (cyclin A1, cyclin-dependent kinase 2, Bcl2, and Bax) in NSCLC cell lines and tumour xenografts in nude mice. 32820252 KTN1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-23b/DEPDC1 axis] RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay We identified a novel NSCLC-related lncRNA, KTN1 antisense RNA 1 (KTN1-AS1) which was demonstrated to be distinctly highly expressed in NSCLC.Overall, our findings imply that STAT1-induced upregulation of KTN1-AS1 display tumor-promotive roles in NSCLC progression via regulating miR-23b/DEPDC1 axis, suggesting that KTN1-AS1 may be a novel biomarker and therapeutic target for NSCLC patients. Clinical study also suggested that higher levels of KTN1-AS1 were associated with advanced clinical progression and a shorter five-year overall survival. Yes Functionally, loss-of-function assays with in vitro and in vivo experiments revealed that KTN1-AS1 promoted the proliferation, migration, invasion and EMT progress of NSCLC cells, and suppressed apoptosis. 32396871 KTN1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma esophageal cancer cells and ESCC tissues Interaction(RBBP4/HDAC1) RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay//ChIP Considerable upregulation of KTN1-AS1 was confirmed in esophageal cancer cells and ESCC tissues and its expression was associated with TNM stage, pathological differentiation, and lymph node metastasis. SOX2 directly activated transcription of KTN1-AS1, and overexpression of KTN1-AS1 facilitated ESCC cells proliferation and invasion in vitro and in vivo. Furthermore, KTN1-AS1 could bind to retinoblastoma binding protein 4 (RBBP4) in the nucleus and enhanced its binding with histone deacetylase 1 (HDAC1), thereby activating the epithelial-mesenchymal transition (EMT) process through downregulating E-cadherin expression at the epigenetic level. Considerable upregulation of KTN1-AS1 was confirmed in esophageal cancer cells and ESCC tissues and its expression was associated with TNM stage, pathological differentiation, and lymph node metastasis. Yes SOX2 directly activated transcription of KTN1-AS1, and overexpression of KTN1-AS1 facilitated ESCC cells proliferation and invasion in vitro and in vivo. 36418920 KTN1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[miR-23c/ERBB2IP axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Further analyses revealed that higher expression of KTN1-AS1 was observed in HCC tissues with large tumor size, high tumor grade and advanced TNM stage.Mechanistically, KTN1-AS1 inversely regulated miR-23c abundance in HCC cells. Further evidence supported that KTN1-AS1 acted as a competing endogenous RNA (ceRNA) by directly sponging miR-23c in HCC cells. Interestingly, erbb2 interacting protein (ERBB2IP), a known target of miR-23c, was positively regulated by KTN1-AS1 and its restoration reversed KTN1-AS1 knockdown attenuated HCC cell growth. Further analyses revealed that higher expression of KTN1-AS1 was observed in HCC tissues with large tumor size, high tumor grade and advanced TNM stage. Yes Functionally, KTN1-AS1 knockdown suppressed cell proliferation and colony formation, and increased apoptosis of SMMC-7721 cells in vitro. Furthermore, silencing of KTN1-AS1 restrained tumor growth of HCC in vivo. 30551364 KTN1-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-505-3p/ZNF326 axis) qRT-PCR//Wound Healing Assay//ChIP//Transwell Assay The data showed that KTN1-AS1 and ZNF326 had a high expression in OC than in the normal tissue, and miR-505-3p exhibited a low expression in OC than in the normal tissue. In terms of mechanical exploration, KTN1-AS1 was transcriptionally activated by histone H3 on lysine 27 acetylation (H3K27ac) at the promoter region, and KTN1-AS1 increased ZNF326 expression by competitively adsorbing miR-505-3p. Yes The knockdown of KTN1-AS1 caused an inhibition in OC cell proliferation, migration, and invasion, and promoted cell apoptosis. 35722429 KTN1-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer cells Interaction(EP300/H3K27Ac) qRT-PCR//Wound Healing Assay KTN1-AS1 silencing inhibited the proliferation, invasion, and migration of bladder cancer cells, while KTN1-AS1 overexpression had the obvious opposite effects. Mechanistically, KTN1-AS1 promoted the recruitment of EP300, a histone acetyltransferase that enriched acetylation of histone H3 at lysine 27 (H3K27Ac) in the KTN1 promoter region. This epigenetic modulation contributed to the up-regulation of KTN1, which affected bladder cancer growth and progression via the regulation of Rho GTPase (RAC1, RHOA, and CDC42)-mediated signaling. Yes KTN1-AS1 silencing inhibited the proliferation, invasion, and migration of bladder cancer cells, while KTN1-AS1 overexpression had the obvious opposite effects. 33480975 KTN1-AS1 LncRNA Homo sapiens Glioma GBM tissues and cell lines regulation[KTN1-AS1/miR-505-3p axis ] Cell Proliferation Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, reverse transcription quantitative PCR analysis was conducted and the results demonstrated that KTN1?AS1 was upregulated in GBM tissues and cell lines compared with normal tissues and astrocytes (NHA). Taken together, the results from the present provided novel insights into the roles of KTN1‑AS1 in GBM, and suggested that the KTN1‑AS1/miR‑505‑3p axis may be considered as a novel therapeutic target for the treatment of patients with GBM. Yes Furthermore, KTN1?AS1 knockdown decreased the viability and invasive ability of glioma cells in vitro and in vivo. 33125151 KTN1-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and PC cells Interaction(microRNA-23b-3p) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//RNA-seq//Transwell Assay We identified that KTN1-AS1 presented a most significant elevation in the PC tissues. KTN1-AS1 inhibited miR-23b-3p expression by binding to it. We identified that high KTN1-AS1 expression was correlated with the poor survival rate of the PC patients. Yes Knockdown of KTN1-AS1 suppressed the proliferation and invasion of PC cells but accelerated their apoptosis, observably up-regulated pro-apoptotic Bax and Caspase-3 expression, and remarkably down-regulated the anti-apoptotic bcl-2 expression (P < 0.05). While on the contrary, KTN1-AS1 could further induce the proliferation/invasion and inhibit apoptosis of PC cells, and meanwhile, markedly declined Bax and Caspase-3 expression, and dramatically enhanced bcl-2 expression.  34461605 KTN1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation(CDK1) Cell Proliferation Assay//qRT-PCR//Cell Cycle Assay//Western Blot KTN1-AS1 was upregulated in NSCLC tissues and its expression level was positive correlated with CDK1 expression. KTN1-AS1 silencing induced G1 phase cell cycle arrest of NSCLC cells and downregulated CDK1. Moreover, KTN1-AS1 silencing suppressed NSCLC cell proliferation and CDK1 overexpression attenuated the effects of KTN1-AS1 silencing on cell proliferation. KTN1-AS1 may regulate cell cycle progression in NSCLC by regulating CDK1. KTN1-AS1 expression was not changed with clinical stages increasing, and higher KTN1-AS1 levels were associated with poor survival of NSCLC patients. Yes KTN1-AS1 silencing induced G1 phase cell cycle arrest of NSCLC cells and downregulated CDK1. Moreover, KTN1-AS1 silencing suppressed NSCLC cell proliferation and CDK1 overexpression attenuated the effects of KTN1-AS1 silencing on cell proliferation. KTN1-AS1 may regulate cell cycle progression in NSCLC by regulating CDK1. 35381130 KTN1-AS1 LncRNA Homo sapiens Burkitt Lymphoma different types of B cell lymphoma Regulation( Myc-target genes) Microarray//qRT-PCR//Western Blot We show that the top Myc-induced lncRNA KTN1-AS1 is strongly upregulated in different types of B cell lymphoma compared with their normal counterparts. Global gene expression analysis upon KTN1-AS1 depletion shows a strong enrichment of key genes in the cholesterol biosynthesis pathway as well as co-regulation of many Myc-target genes, including a moderate negative effect on the levels of Myc itself. Our study suggests a critical role for KTN1-AS1 in supporting BL cell growth by mediating co-regulation of a variety of Myc-target genes and co-activating key genes involved in cholesterol biosynthesis. Yes Knockdown of KTN1-AS1 revealed a strong negative effect on the growth of three BL cell lines. 35866590 KRT19P3 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[NF-κB pathway] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay The present study confirmed the downregulation of KRT19P3 in GC tissues and cells.Enforced expression of KRT19P3 significantly inhibited cell proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. Conversely, KRT19P3 knockdown had opposite effects. Decreased expression of KRT19P3 was correlated with larger tumor size, advanced TNM stage, Lauren's classification, positive lymph node metastasis, and poor prognosis. Yes Enforced expression of KRT19P3 significantly inhibited cell proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. Conversely, KRT19P3 knockdown had opposite effects. 31409899 KRT19P3 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression [lower expressed] qRT-PCR//Invasion Assay//EdU Staining//Migration Assay In the present study, we first discovered that KRT19P3 was downregulated in BC tissues compared with para cancer tissue. Then we showed that KRT19P3 could be used as a marker to differentiate BC from para cancer tissue. Comparison of clinical parameters showed an inverse relationship between the expression of KRT19P3 and pathological grade. Yes Increased expression of KRT19P3 markedly inhibited the proliferation, migration, and invasion rate of BC cells in vitro and tumor growth of BC in vivo. Conversely, KRT19P3 knockdown by siRNA markedly promoted the proliferation, migration, and invasion rate of BC cells after being transfected. 35059320 KRT16P3 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues Regulation(JAK2/STAT3 signaling pathway) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//BrdU//Colony Formation Assay//Invasion Assay//Transwell Assay We found KRT16P3 expression is significantly upregulated in TSCC tissues and positively associated with advanced clinicopathological features of TSCC patients, and it may serve as a poor prognostic factor. Furthermore, we also revealed that KRT16P3 knockdown suppresses EMT and JAK2/STAT3 signaling pathway. Yes Functionally, KRT16P3 knockdown inhibits proliferation, migration, invasion and promotes apoptosis of TSCC cells. 33220105 KRT16P2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues regulation[KRT16P2/miR-1294/EGFR axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The present study analyzed online data and identified lncRNA KRT16P2 as a significantly upregulated long non-coding RNA (lncRNA) in LSCC. In conclusion, we demonstrated a lncRNA KRT16P2/miR-1294/EGFR axis that regulates LSCC cell proliferation, invasion, and migration. Yes KRT16P2 knockdown in LSCC cells inhibited cancer cell proliferation, invasion, and migration. 32655821 KLHDC7B-DT LncRNA Homo sapiens Chlorophyll A Regulation( IL-6 /STAT3 ) Western Blot//Migration Assay//qRT-PCR//FISH//Cell Proliferation Assay//ELISA//Invasion Assay//ChIP In the present study, we identified a long noncoding RNA (lncRNA) KLHDC7B divergent transcript (KLHDC7B-DT), which was up-regulated in PDAC and correlated with poor survival of PDAC patients. Mechanistically, KLHDC7B-DT was found to directly bind IL-6 promoter, induce open chromatin structure at IL-6 promoter region, activate IL-6 transcription, and up-regulate IL-6 expression and secretion. Via inducing IL-6 secretion, KLHDC7B-DT activated STAT3 signaling in PDAC cells in an autocrine manner. In the present study, we identified a long noncoding RNA (lncRNA) KLHDC7B divergent transcript (KLHDC7B-DT), which was up-regulated in PDAC and correlated with poor survival of PDAC patients. Yes Functional assays demonstrated that KLHDC7B-DT enhanced PDAC cell proliferation, migration, and invasion. 33538300 KLF3-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer cells Interaction(miR-223) In Vivo Experiment//Wound Healing Assay//Invasion Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay " In this study, we found that KLF3-AS1 was down-regulated in gastric cancer cells. The mechanistic studies showed that KLF3-AS1 could act as the ""sponge"" for miR-223 and to repress miR-223 expression in gastric cancer cells. Overexpression of miR-223 reversed the inhibitory effects of KLF3-AS1 overexpression on gastric cancer cell proliferation, invasion, migration and EMT, and attenuated the enhanced effects of KLF3-AS1 overexpression on gastric cancer cell chemosensitivity to cisplatin. " Yes Overexpression of KLF3-AS1 repressed gastric cancer cell proliferation, growth. In addition, KLF3-AS1 overexpression also exerted inhibitory effects on the gastric cancer cell invasion, migration and EMT, but promoted chemosensitivity of gastric cancer cells to cisplatin. 34745937 KLF3-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cell lines regulation[Impairing miR-185-5p-Targeted KLF3 Inhibition] RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//FISH//Luciferase Report Assay//Transwell Assay LncRNA KLF3-AS1 was found to be poorly expressed in ESCC and could upregulate the expression of KLF3 by binding to miR-185-5p. Collectively, this study indicated that lncRNA KLF3-AS1 inhibited ESCC cell invasion and migration by impairing miR-185-5p-mediated inhibition of KLF3, highlighting a promising novel potential target for ESCC treatment. Yes Furthermore, enhancement of lncRNA KLF3-AS1 resulted in reduced colony formation ability, cell invasion and migration, and tumor volume in vivo while promoting cell apoptosis in ESCC through downregulation of miR-185-5p. 32193151 KLF3-AS1 LncRNA Homo sapiens Osteoarthritis chondrocytes Interaction(YBX1/PI3K/Akt/mTOR signaling pathway) RNA Pull-Down//Western Blot//qRT-PCR//Cell Apoptosis Assay//Cell Viability Assay We found that MSC-Exo enhanced KLF3-AS1 expression in IL-1β-treated chondrocytes. Moreover, KLF3-AS1 interacted with YBX1 in chondrocytes. MSC-Exo-mediated KLF3-AS1 activated PI3K/Akt/mTOR signaling pathway, which was abrogated by YBX1 silencing. MSC-Exo-mediated KLF3-AS1 repressed autophagy and apoptosis of chondrocytes by activating PI3K/Akt/mTOR signaling pathway. Yes MSC-Exo-mediated KLF3-AS1 promoted cell viability and repressed apoptosis of IL-1β-treated chondrocytes. Rapamycin (autophagy activator) promoted cell viability and suppressed apoptosis of chondrocytes by activating autophagy. 34964696 LENGA LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(BRD7/TP53 signaling) RNA Pull-Down//Western Blot//Co-IP//Migration Assay//CCK8//FISH//RIP//qRT-PCR//Colony Formation Assay//Invasion Assay Next, we found that reduced expression of LENGA in GC was also associated with a shorter life expectancy. The proliferation, migration, and invasion of GC cells were increased after LENGA knockdown but restrained after LENGA overexpression in vitro and in vivo. Yes The proliferation, migration, and invasion of GC cells were increased after LENGA knockdown but restrained after LENGA overexpression in vitro and in vivo. 36477655 LENOX LncRNA Homo sapiens Melanoma melanoma cells Interaction(RAP2C) In Vivo Experiment//qPCR//Flow Cytometry Aiming to overcome this, we identified LINC00518 (LENOX; lincRNA-enhancer of oxidative phosphorylation) as a melanoma-specific lncRNA expressed in all known melanoma cell states and essential for melanoma survival in vitro and in vivo. Mechanistically, LENOX promoted association of the RAP2C GTPase with mitochondrial fission regulator DRP1, increasing DRP1 S637 phosphorylation, mitochondrial fusion, and oxidative phosphorylation. Aiming to overcome this, we identified LINC00518 (LENOX; lincRNA-enhancer of oxidative phosphorylation) as a melanoma-specific lncRNA expressed in all known melanoma cell states and essential for melanoma survival in vitro and in vivo. Yes Mechanistically, LENOX promoted association of the RAP2C GTPase with mitochondrial fission regulator DRP1, increasing DRP1 S637 phosphorylation, mitochondrial fusion, and oxidative phosphorylation. LENOX expression was upregulated following treatment with MAPK inhibitors, facilitating a metabolic switch from glycolysis to oxidative phosphorylation and conferring resistance to MAPK inhibition. 36214632 LET LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Interaction[regulating miR-373-3p] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot LncRNA-LET expression was lower in ccRCC tissues than that in the matched adjacent non-tumor tissues (n = 16). Moreover, we noted that lncRNA-LET may act as a target for oncomiR miR-373-3p. In contrast to lncRNA-LET, miR-373-3p expression was higher in ccRCC tissues. The binding between lncRNA-LET and miR-373-3p was validated. Two downstream targets of miR-373-3p, Dickkopf-1 (DKK1) and tissue inhibitor of metalloproteinase-2 (TIMP2), were positively regulated by lncRNA-LET in ccRCC cells. MiR-373-3p mimics reduced lncRNA-LET-induced up-regulation of DKK1 and TIMP2 levels, and attenuated lncRNA-LET-mediated anti-tumor effects in ccRCC cells. In vivo, lncRNA-LET suppressed the growth of ccRCC xenograft tumors. Yes In vitro, lncRNA-LET overexpression induced cell cycle arrest, promoted apoptosis and impaired mitochondrial membrane potential, whereas its knockdown exerted opposite effects. 31768131 LINC00261 LncRNA Homo sapiens Prostatic Neoplasms NEPC specimens Interaction(CBX2-FOXA2 axes) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Colony Formation Assay//RIP//MTT//RNA-seq//ChIP-seq//IHC Here, LINC00261 emerged as the top gene with over 3229-fold upregulation in NEPC. Consistently, LINC00261 expression was significantly upregulated in NEPC specimens in multiple patient cohorts.In the cell cytoplasm, LINC00261 binds to and sequesters miR-8485 from targeting the CBX2 mRNA, while inside the nucleus, LINC00261 functions as a transcriptional scaffold to induce SMAD-driven expression of the FOXA2 gene. Yes Knockdown of LINC00261 in PC-3 cells dramatically attenuated its proliferative and metastatic abilities, which are explained by parallel downregulation of CBX2 and FOXA2 through distinct molecular mechanisms. 33793068 LINC00243 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[sponging miR-507] CCK8//qRT-PCR//RNA Pull-Down//Western Blot LINC00243 expression increased in human NSCLC tissues and associated with poor prognosis of NSCLC patients.Mechanically, LINC00243 acted as a molecular sponge for miR-507, and miR-507 reversed the effect of LINC00243 on promoting proliferation and glycolysis of NSCLC cells. Moreover, LINC00243 modulated expression of endogenous miR-507-targeted PDK4. LINC00243 promotes proliferation and glycolysis in NSCLC cells by positively regulating PDK4 through sponging miR-507. LINC00243 could be the potential target for NSCLC treatment clinically. Yes LINC00243 knockdown inhibited proliferation and glycolysis of NSCLC cells. 31595421 LINC00242 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[ LINC00242/miR-141/FOXC1 axis] CCK8//qRT-PCR//RIP//Transwell Assay LINC00242 was highly expressed in GC tissues and cells and contributed to poor prognosis. Taken together, the present study demonstrates the oncogenic role of the LINC00242/miR-141/FOXC1 axis in GC, highlighting a theoretical basis for GC treatment. Yes LINC00242 knockdown inhibited HGC27 cell viability, migration and invasion, and tube formation of HBMVECs. 32587479 LINC00240 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[ miR-124-3p / DNMT3B axis] qRT-PCR//Luciferase Report Assay//RIP Our findings suggested higher LINC00240 expression in GC tissues and cells.Then we reveal that LINC00240 acts as an oncogene in GC progression via the miR-99a-5p/IGF1R axis. Yes Through downregulating LINC00240, cell proliferation, invasion and migration were retarded in vitro, and tumorigenesis of GC cells was notably suppressed in vivo. 32526811 LINC00240 LncRNA Homo sapiens Stomach Neoplasms GC tissues and GC cell lines Interaction(miR-338-5p/METTL3 axis) Western Blot//Bioinformatics Analysis//Migration Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Invasion Assay We first demonstrated that LINC00240 was upregulated in GC tissues and GC cell lines. We further identified and validated the functional interaction between LINC00240 and miR-338-5p. miR-338-5p seemed to function as a downstream target negatively regulated by LINC00240, and miR-338-5p could target METTL3 at 3' UTR to downregulate its expression. In GC tissues, the expression of miR-338-5p was negatively correlated with LINC00240, and the expression of miR-338-5p was negatively correlated with METTL3. High expression of LINC00240 was associated with advanced TNM stage, a higher extent of distant metastasis and lymph nodes metastasis, and the poor overall and disease-free survival of the patients. Yes In GC cell lines, the knockdown of LINC00240 inhibited GC cell proliferation and migration, but induced cell apoptosis. 34842045 LINC00240 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer cell line Interaction(miR-7-5p) qRT-PCR//Luciferase Report Assay//Invasion Assay//Migration Assay We found that LINC00240 was downregulated in lung cancer cell line after miR-7-5p transfection with an miR-7-5p mimic. Further investigations revealed that the knockdown of LINC00240 induced the overexpression of miR-7-5p. Yes The overexpression of miR-7-5p diminished cancer invasion and migration. The EGFR expression was down regulated after siRNA treatment for LINC00240. Silencing LINC00240 suppressed the invasion and migration of lung cancer cells, whereas LINC00240 overexpression exerted the opposite effect. 33422052 LINC00239 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(MBP-1/c-Myc axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//ChIP LINC00239 was highly expressed in ESCC tissues and cells, and was related to poor prognosis of patients with ESCC. LINC00239 may function as an oncogenic lncRNA in ESCC through the LINC00239/MBP-1/c-Myc axis to activate EMT process. LINC00239 was highly expressed in ESCC tissues and cells, and was related to poor prognosis of patients with ESCC. Yes The proliferation, metastasis, and invasion ability as well as epithelial-mesenchymal transition (EMT) process were all enhanced in LINC00239-overexpressed ESCC cells. LINC00239 was upregulated in TGF-β1-treated ESCC cells. 34016746 LINC00210 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines interaction[sponging microRNA-328-5p] CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay The results demonstrated that LINC00210 was upregulated in NSCLC tissues and cell lines compared with that in normal tissues and 16-HBE cells, and that LINC00210 expression was associated with a poor prognosis in patients with NSCLC (P<0.05). These findings suggest that LINC00210 may serve as an oncogenic role in NSCLC by sponging miR-328-5p. The results demonstrated that LINC00210 was upregulated in NSCLC tissues and cell lines compared with that in normal tissues and 16-HBE cells, and that LINC00210 expression was associated with a poor prognosis in patients with NSCLC (P<0.05). Yes Furthermore, A549 cell transfection with small interfering (si)LINC00210#1 and siLINC00210#2 induced a significant decrease in cell proliferation, and migratory and invasive abilities compared with that in the control groups (P<0.05). 32266029 LINC00210 LncRNA Homo sapiens Glioma glioma tissues interaction[sponging miR-328] qRT-PCR The present study demonstrated that LINC00210 was significantly upregulated in glioma tissues, and high expression of LINC00210 was significantly associated with advanced clinical stage and poor prognosis in patients with glioma.Therefore, the present results suggested that LINC00210 may exert an oncogenic role in glioma via sponging miR-328. The present study demonstrated that LINC00210 was significantly upregulated in glioma tissues, and high expression of LINC00210 was significantly associated with advanced clinical stage and poor prognosis in patients with glioma. Yes It was found that LINC00210 knockdown significantly inhibited the proliferation and migration of U251 and T98G cells. 33110451 LINC00210 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC samples Regulation[NOTCH3 pathway] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that LINC00210 expression was up-regulated in NPC samples.Through inhibiting miR-328-5p activity, LINC00210 promoted NOTCH3 expression in NPC, leading to activation of NOTCH3 signaling pathway. Besides, its overexpression was positively correlated with NPC metastasis while predicting poor prognosis. Yes Based on functional experiments, we revealed that LINC00210 contributed to NPC cell proliferation and invasion in vitro, and promotes tumor growth in vivo 30341249 LINC00210 LncRNA Homo sapiens Thyroid Neoplasms TC tissues Regulation[miR-195-5p/IGF1R/Akt axis ] qRT-PCR Here, we found that Linc00210 expression was upregulated in TC tissues compared to the matched noncancerous tissues. Mechanistically, Linc00210 served as a sponge for miR-195-5p, thereby counteracting its ability in downregulating the expression of IGF1R and the activation of PI3K/Akt signaling. Yes Overexpression of Linc00210 augmented the proliferation, migration, and invasion of TC cells. 31240707 LINC00205 LncRNA Homo sapiens Stomach Neoplasms GC tissues and several cell lines Regulation(miRNA-26a) FISH//Luciferase Report Assay//RIP Both public datasets and our data showed that the LINC00205 was highly expressed in GC tissues and several cell lines. Notably, GC patients with high level of LINC00205 had a poor prognosis in our cohort. Mechanistically, knockdown of LINC00205 by shRNAs suppressed GC cells proliferation, migration, invasion remarkably, and induced cell cycle arrest. Based on bioinformatics prediction, we found that LINC00205 might act as a competitive endogenous RNA (ceRNA) through targeting miR-26a. The level of miR-26a had negatively correlated with LINC00205 expression and was decreased among GC cell lines, tissues, and serum samples. Our results for the first time confirmed that miR-26a was a direct target of LINC00205 and might have the potential to become a plasma marker for clinical tumor diagnosis. Indeed, LINC00205 knockdown resulted in the dramatic promotion of miR-26a expression as well as inhibition of miR-26a potential downstream targets, such as HMGA2, EZH2, and USP15. These targets were essential for cell survival and epithelial-mesenchymal transition. Importantly, LINC00205 was able to remodel the miR-26a-mediated downstream silence, which identified a new mechanism of malignant transformation of GC cells. Our results for the first time confirmed that miR-26a was a direct target of LINC00205 and might have the potential to become a plasma marker for clinical tumor diagnosis. Yes Mechanistically, knockdown of LINC00205 by shRNAs suppressed GC cells proliferation, migration, invasion remarkably, and induced cell cycle arrest. 35013132 LINC00205 LncRNA Homo sapiens Lung Neoplasms LC tissues and cells regulation[FUS ,CSDE1] RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//RIP In the present study, we observed the elevated expression of LINC00205 in LC tissues and cells through real-time quantitative PCR (RT-qPCR). These findings demonstrated that LINC00205 facilitates malignant phenotypes in LC by recruiting FUS to stabilize CSDE1, suggesting LINC00205 as a potential target for LC therapy. Yes Additionally, silencing LINC00205 inhibited LC cell growth and migration, but aggravated cell apoptosis. 32808651 LINC00205 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell line Interaction(YY1/miR-26a-5p/CDK6 pathway) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay LINC00205 was strongly expressed in HCC tissues and cell lines. Mechanistically, we illustrated that LINC00205 could accelerate the proliferation of HCC cells by boosting CDK6 expression via sponging miR-26a-5p. Moreover, we unveiled that LINC00205 could be activated by transcription factor Yin Yang-1 (YY1) as its direct downstream target. Elevated LINC00205 expression was positively associated with worse prognosis as well as pathological grade in HCC. Yes Suppression of LINC00205 could impede the proliferation of HCC cells by triggering the G0/G1-phase cell cycle arrest and apoptosis in vitro. 34730201 LINC00205 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines Interaction(miR-185-5p) In Vivo Experiment//Western Blot//qPCR//Migration Assay//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this study, we discovered that LINC00205 was markedly upregulated in LUAD tissues and cell lines and correlated with poor prognosis of patients with LUAD. Notably, the tumor suppressor miR-185-5p was found to be a direct target of LINC00205. In addition, miR-185-5p diminished the promotion of cell proliferation and migration mediated by LINC00205, whereas miR-185-5p inhibition had the opposite effect. In this study, we discovered that LINC00205 was markedly upregulated in LUAD tissues and cell lines and correlated with poor prognosis of patients with LUAD. Yes Our data showed that LINC00205 promoted the migration and proliferation of LUAD cells in vitro and tumor growth in vivo. 34270733 LINC00205 LncRNA Homo sapiens Hepatoblastoma HB tissues and cell lines Regulation(microRNA-154-3p/Rho-associated coiled-coil Kinase 1 axis) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Invasion Assay Yes In addition, knockdown of Linc00205 led to suppression of HB development. Moreover, we identified that Linc00205 was able to directly bind to miR-154-3p, thus isolating miR-154-3p from its target Rho-associated coiled-coil Kinase 1 (ROCK1). 35179516 LINC00200 LncRNA Homo sapiens Stomach Neoplasms Gastric Cancer tissues,cell lines regulation[miR-143-3p/SERPINE1 Axis] qRT-PCR//Luciferase Report Assay LINC00200 was found to be upregulated in GC tissues and cell lines. LINC00200 is significantly overexpressed in GC and accelerates GC progression through regulating miR-143-3p/SERPINE1 axis. Yes Moreover, knockdown of LINC00200 suppressed GC cell proliferation, invasion and migration in vitro and inhibited tumorigenesis in mouse xenografts. 33141390 LINC00184 LncRNA Homo sapiens Cholangiocarcinoma cholangiocarcinoma cells Interaction(hsa-miR-23b-3p/ANXA2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Bioinformatics Analysis//Transwell Assay We discovered that LINC00184 expression was heightened in cholangiocarcinoma patients and cells. Knockdown of LINC00184 repressed cell proliferation, invasion, migration and adenine metabolism in cholangiocarcinoma cells. miR-23b-3p was regarded as a target of LINC00184 and its depletion perversed the inhibitive influence of LINC00184 silencing on cholangiocarcinoma cells. ANXA2 was a target of miR-23b-3p and was negatively modulated by miR-23b-3p. Moreover, ANXA2 was positively modulated by LINC00184 via sponging miR-23b-3p. In short, silencing of LINC00184 suppressed cell proliferation, invasion and migration through over-expression of miR-23b-3p and reducing of ANXA2 in cholangiocarcinoma cells. These findings contribute to understanding the influences of LINC00184, miR-23b-3p, and ANXA2 on cholangiocarcinoma and provide basis for cholangiocarcinoma treatment. Yes Knockdown of LINC00184 repressed cell proliferation, invasion, migration and adenine metabolism in cholangiocarcinoma cells. miR-23b-3p was regarded as a target of LINC00184 and its depletion perversed the inhibitive influence of LINC00184 silencing on cholangiocarcinoma cells. ANXA2 was a target of miR-23b-3p and was negatively modulated by miR-23b-3p. 33913242 LINC00174 LncRNA Homo sapiens Colorectal Neoplasms CRC clinical samples and cells Interaction(MiR-3127-5p/ E2F7 Axis) qRT-PCR//Wound Healing Assay//Colony Formation Assay//Western Blot LINC00174 was up-regulated in CRC clinical samples and cells and was related to the clinical characteristics of CRC patients. Our research reveals that LINC00174 affected the biological characteristics of CRC cells through regulated miR-3127-5p/ E2F7 axis. LINC00174 was up-regulated in CRC clinical samples and cells and was related to the clinical characteristics of CRC patients. Yes High-expression of LINC00174, contrary to the effect of siLINC00174, promoted cell viability, proliferation, migration and invasion, up-regulated the expressions of N-Cadherin, Vimentin, E2F7, and inhibited the expression of E-Cadherin. 34226413 LINC00244 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Regulation qRT-PCR To explore the epigenetic regulation of PD-L1, we identified an lncRNA, LINC00244, which reduced PD-L1 expression and predicted good clinical outcomes in hepatocellular carcinoma (HCC). LINC00244 inhibited the proliferation, invasion, and metastasis of HCC by downregulating PD-L1 expression. In addition, low LINC00244 expression activated epithelial-mesenchymal transition (EMT) pathways and facilitated the rapid growth and metastasis of HCC cells. Thus, LINC00244 is a potential therapeutic target for HCC. Yes LINC00244 inhibited the proliferation, invasion, and metastasis of HCC by downregulating PD-L1 expression. 35266439 LINC00261 LncRNA Homo sapiens Acute Kidney Injury serum of patients with sepsis Interaction(miR-654-5p/SOCS3 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//ELISA//Bioinformatics Analysis In this study, we found the expression of LINC00261 was significantly decreased in the serum of patients with sepsis than healthy controls. A similar result was also observed in the mouse model of sepsis induced by lipopolysaccharide (LPS). Mechanistically, we confirmed that LINC00261 could function as a sponge to combine with microRNA-654-5p (miR-654-5p) which inhibits nuclear factor-κB (NF-κB) activity by targeting suppressor of cytokine signaling 3 (SOCS3). Yes Further investigations revealed that overexpression of LINC00261 improved the viability, suppressed the apoptosis and reduced the generation of inflammatory cytokines in LPS-treated HK-2 cells. 33481135 LET LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cells Interaction(miR-548k ) Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay Mechanistically, we found that miR-548k directly targets and represses the expression of long noncoding RNA-LET (lncRNA-LET), and further down-regulates p53 and up-regulates NF90. In addition, we found that lncRNA-LET is down-regulated and inversely correlated with miR-548k in ESCC. Down-regulated lncRNA-LET also indicated poor overall survival of ESCC patients. Yes Functional assays demonstrated that lncRNA-LET inhibits the proliferation and migration of ESCC cells, and the effects of miR-548k on ESCC are dependent on the negative regulation of lncRNA-LET. 29126868 LINC00261 LncRNA Homo sapiens Cardiomyocyte Hypoxia/Reoxygenation Injury myocardial tissues and H9C2 cell regulation[LINC00261/miR-23b-3p/NRF2 axis] qRT-PCR//Luciferase Report Assay//RIP//ChIP The expression of LINC00261 was significantly down-regulated in myocardial tissues and H9C2 cell. Our findings reveal a novel role for LINC00261 in regulating H/R cardiomyocyte apoptosis and the potency of the LINC00261/miR-23b-3p/NRF2 axis as a therapeutic target for the treatment of MIRI. Yes Overexpression of LINC00261 improves cardiac function and reduces myocardium apoptosis. 32558131 LINC00265 LncRNA Homo sapiens Precursor Cell Lymphoblastic Leukemia-Lymphoma ALL cell lines and blood of patients Interaction(miR-4500/STAT3 Axis) In Vivo Experiment//RNA Pull-Down//Transfection//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//migration assay LINC00265 was highly expressed in ALL cell lines and blood of patients with ALL and facilitated the proliferation, migration, invasion, and growth of xenograft tumors of ALL cells. RNA pull-down and luciferase assays demonstrated that LINC00265 competitively targeted miR-4500 and enhanced STAT3 expression. Furthermore, miR-4500 inhibitors or overexpressed LINC00265 up-regulated STAT3 expression, and miR-4500 mimics or STAT3 shRNAs eliminated the LINC00265-induced malignancy of the ALL cells. Yes LINC00265 was highly expressed in ALL cell lines and blood of patients with ALL and facilitated the proliferation, migration, invasion, and growth of xenograft tumors of ALL cells. silencing of LINC00265 expression with LINC00265 siRNA significantly inhibited the malignancy of the ALL cells. 34737643 LINC00261 LncRNA Homo sapiens Breast Neoplasms BC tissues of patients and cell lines Interaction(microRNA-550a-3p/SDPR axis ) RNA Pull-Down//Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay Reduced LINC00261, decreased SDPR and elevated miR-550a-3p exhibited in BC tissues of patients and cell lines. LINC00261 up-regulated SDPR expression as a sponge of miR-550a-3p. Moreover, up-regulated miR-550a-3p reversed the inhibitive effect of elevated LINC00261 on BCSCs, and reduced SDPR reversed the promotive effect of decreased miR-550a-3p on BCSCs. Yes Elevated LINC00261 suppressed BC cell viability, MS formation ability, migration and invasion of CD44+ /CD24-/low BCSCs. 33274565 LINC00261 LncRNA Homo sapiens Lung Neoplasms LC tissues and cells regulation[miR-1269a/FOXO1 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In LC, LINC00261 expression was down-regulated, and was associated with more advanced TNM stage, metastasis and a shorter survival time.Down-regulation of LINC00261 expression has a prognostic value in LC, and overexpression LINC00261 inhibits LC progression via targeting miR-1269a/FOXO1 axis. In LC, LINC00261 expression was down-regulated, and was associated with more advanced TNM stage, metastasis and a shorter survival time. Yes LINC00261 overexpression inhibited the growth and metastasis of LC cells in vitro and tumor growth in vivo. 32607060 LINC00261 LncRNA Homo sapiens Colonic Neoplasms cell lines Interaction[Wnt/β-catenin pathway] RIP Here, we found LINC00261 was reduced in colon cancer cells.In the current study, miR-324-3p was examined and miR-324-3p was greatly increased in colon cancer cells. Moreover, the association between miR-324-3p and LINC00261 was confirmed via performing RNA immunoprecipitation and RNA-pull-down experiments. In cancer biology, aberrant modulation of the Wnt signaling pathway remains a prevalent theme. Overexpression of LINC00261 obviously impaired colon cancer progression via inactivating the Wnt pathway. Furthermore, in the xenograft model assay, an increase of LINC00261 could suppress colon tumor growth via sponging miR-324-3p and inactivating the Wnt pathway. Yes Meanwhile, overexpressed LINC00261 repressed colon cancer cell viability and proliferation capacity. In addition, colony cancer cell colony formation was inhibited and apoptosis was enhanced by upregulation of LINC00261. 31183860 LINC00261 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Regulation( TGF-β1/SMAD3 signaling) qRT-PCR Previously, we found that linc00261 was down-regulated in HCC and associated with multiple worse clinical pathological parameters and poor prognosis.Furthermore, we revealed that linc00261 suppressed the expression and phosphorylation of SMAD3 (p-SMAD3), which could be core transcriptional modulator in TGF-β1 signaling mediated EMT and the acquisition of stemness traits. A negative correlation between linc00261 and p-SMAD3 was determined in HCC samples. Previously, we found that linc00261 was down-regulated in HCC and associated with multiple worse clinical pathological parameters and poor prognosis. Yes Here, we show that linc00261 was down-regulated in TGF-β1 stimulated cells, and forced expression of linc00261 attenuated EMT and stem-like traits in HCC. Linc00261 also inhibited the tumor sphere forming in vitro and decreased the tumorigenicity in vivo. 35123494 LINC00261 LncRNA Homo sapiens Endometrial Neoplasms Regulation[miRNA/FOXO1 expression] qRT-PCR We found that LINC00261 mRNA levels were downregulated in endometrial carcinoma, and LINC00261 overexpression inhibited endometrial carcinoma cell proliferation, migration, and invasion. LINC00261 elevates FOXO1 protein levels through reducing FOXO1-targeted miRNAs to suppress endometrial carcinoma cell proliferation, migration, and invasion. Yes LINC00261 overexpression inhibits cancer cell proliferation, migration, and invasion. 30019459 LINC00261 LncRNA Homo sapiens Thyroid Neoplasms TC tumor tissues Regulation(EBF1) Western Blot//Transfection//qRT-PCR//migration assay//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay qRT-PCR analysis showed that LINC00261 level was markedly reduced in TC tumor tissues, as well as corresponding cell lines. Bioinformatics analysis suggested that LINC00261 could target EBF1. Luciferase reporter gene experiment and qRT-PCR analysis suggested that LINC00261 could target EBF1 and that their expressions showed a negative correlation in TC tumor tissues and cells. Retrospective analysis showed that low expression of LINC00261 was in positive correlation with the pathological stage, lymphatic and distant metastasis in patients with TC, meanwhile, the expression of LINC00261 was also in positive correlation with overall survival rate of TC patients. Yes Cell functional experiments confirmed that LINC00261 can inhibit the proliferative and migration ability of TC cells. Subsequently, the recovery experiment also suggested that silencing EBF1 could reverse the promotion effect of LINC00261 knockdown on the proliferative and migration ability of TC cells; while EBF1 overexpression could reverse the inhibition of LINC00261 on the proliferative and migration ability of TC cells. 34982424 LINC00261 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and serums Expression[lower expressed] qRT-PCR//MTT The results showed that LINC00346, LINC00578, and LINC00673 were highly expressed, whereas LINC00671, LINC00261, and SNHG9 were lowly expressed in PC tissues and serums, and their expression levels were correlated with clinical stages. Survival analysis indicated that patients with high expression of LINC00346, LINC00578, or LINC00673 had significantly lower survival rate, while patients with high expression of LINC00671, LINC00261, and SNHG13 had significantly higher survival rate. Yes In addition, we also found that silence of LINC00346, LINC00578 and LINC00673 inhibited PC cell proliferation, and silence of LINC00671, LINC00261, and SNHG13 promoted PC cell proliferation. 30210701 LINC00261 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues and cell lines regulation[miR-222-3p/HIPK2/ERK axis] qRT-PCR//Luciferase Report Assay//RIP LINC00261 was downregulated in pancreatic cancer tissues and cell lines. Moreover, LINC00261 exerted its biological function by binding to miR-222-3p to activate the HIPK2/ERK/c-myc pathway. Its reduced expression was correlated with advanced pathological stage and poor prognosis. Yes Forced expression of LINC00261 suppressed pancreatic cancer glycolysis and proliferation and induced cell cycle arrest and apoptosis. 33122827 LINC00261 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues regulation[c-Myc expression] ISH//qRT-PCR//RIP LINC00261 was significantly downregulated in PC tissues, and its expression was positively associated with the prognosis of PC patients. Our findings indicate that methylation-mediated LINC00261 suppresses PC progression by epigenetically repressing c-Myc expression. LINC00261 was significantly downregulated in PC tissues, and its expression was positively associated with the prognosis of PC patients. Yes Phenotypic studies indicated that LINC00261 overexpression significantly suppressed PC cell proliferation, migration and metastasis in vitro and in vivo. 32929371 LINC00261 LncRNA Homo sapiens Pancreatic Neoplasms cell lines regulation[down-regulating miR-23a-3p] Flow Cytometry//qRT-PCR//RIP//MTT//Invasion Assay//Transwell Assay LINC00261 level was decreased in pancreatic cancer cells than that in normal pancreatic ductal epithelial cells. In conclusion, LINC00261 overexpression repressed cell viability and invasion and enhanced apoptosis by decreasing miR-23a-3p expression in pancreatic cancer cells, indicating a new target for the treatment of pancreatic cancer. Low level of LINC00261 indicated low survival probability of pancreatic cancer patients. Yes In conclusion, LINC00261 overexpression repressed cell viability and invasion and enhanced apoptosis by decreasing miR-23a-3p expression in pancreatic cancer cells, indicating a new target for the treatment of pancreatic cancer. 32590069 LINC00261 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines regulation[miR-552-5p/FOXO3 axis] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay Linc00261 expression was significantly decreased in PC tissues and cell lines, and reduced expression was associated with less favorable outcomes in patients with PC.Collectively, the present study demonstrated that Linc00261 inhibited metastasis and the Wnt signaling pathway of PC by regulating the miR‑552‑5p/FOXO3 axis. Yes Linc00261 overexpression inhibited migration and invasion of PC cells in vitro, whereas knockdown of Linc00261 increased migration and invasion. 32020223 LINC00261 LncRNA Homo sapiens Pancreatic Neoplasms Pancreatic cancer tissues Interaction(FOXP3/SCP2 axis) In Vivo Experiment//IHC//Western Blot//Transwell Assay//Transfection//CCK8//qRT-PCR//FISH//RIP//Flow Cytometry//Luciferase Report Assay//ELISA//Colony Formation Assay//Bioinformatics Analysis//ChIP LINC00261 was lowly expressed in PC tissues and cells. SCP2 was inhibited by LINC00261 through FOXP3. Yes Functionally, upregulated LINC00261 or downregulated SCP2 led to reduced cell viability, migration, angiogenesis and tumourigenicity potentials. 34541823 LINC00261 LncRNA Homo sapiens Pancreatic Neoplasms Pc tissues and PC cells and PC stem cells Regulation( ITIH5/GATA6 regulatory pathway) In Vivo Experiment//Western Blot//Transwell Assay//Transfection//CCK8//qRT-PCR//FISH//RIP//Flow Cytometry//Luciferase Report Assay//Microarray//IHC//ChIP Microarray analysis of differentially expressed genes and lncRNAs suggested that LINC00261 is downregulated in PC. Both LINC00261 and ITIH5 were confirmed to be downregulated in PC cells and PC stem cells. The results of dual-luciferase reporter gene, ChIP, and RIP assays indicated that LINC00261 binds directly to GATA6, increasing its activity at the ITIH5 promoter. The presence of LINC00261 and GATA6 inhibited the self-renewal and tumorigenesis of PC stem cells, while silence of ITIH5 rescued those functions. Yes These experiments revealed that the expression of stem cell markers was reduced, and cell proliferation, self-renewal ability, cell invasion, drug resistance, and tumorigenicity were all suppressed by upregulation of LINC00261 or ITIH5. 34446696 LINC00261 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[interacting with miR-522-3p and suppressing Wnt signaling] qRT-PCR In this study, LINC00261 was delineated in NSCLC to be significantly downregulated in cancer tissues compared with corresponding adjacent normal tissues. Taken together, our study demonstrated that LINC00261 suppressed NSCLC cells progression via sponging miR-522-3p and inhibiting Wnt signaling. Low expression of LINC00261 predicted worse survival for patients with NSCLC. Yes Overexpression of LINC00261 in NSCLC cell lines inhibited cell proliferation and invasion, meanwhile promoted apoptosis. 31190356 LINC00261 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Expression[lower expressed] qRT-PCR//Wound Healing Assay//MTT//Western Blot We demonstrated that linc00261 was lowly expressed in NSCLC tissues and cells. Yes Over-expression of linc00261 significantly inhibited proliferation, invasion and migration of NSCLC cells. On the contrast, knockdown of linc00261 promoted cell growth and metastasis of NSCLC cells.Linc00261 could slow down the growth of xenograft of NSCLC in vivo. 31115010 LINC00261 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues,cell lines Interaction[EMT process] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay LINC00261 was overexpressed in cancerous tissues and CCA cell lines compared with adjacent tissues and HIBEC, respectively. Knockdown of LINC00261 expression in RBE and QBC939 cell lines inhibited cell proliferation, migration and invasion property and increased cell apoptosis and the EMT progression. Moreover, there was a strong correlation between LINC00261 and E-cadherin (CDH1) (p < 0.05), and low expression of E-cadherin (CDH1) has a poor overall survival and relapse-free survival in CCA patients (p < 0.05). Up-regulation of LINC00261 was related to larger tumor size (p = 0.009), positive lymph node metastasis (p = 0.021), advanced TNM stages (p = 0.017) and higher postoperative recurrence (p = 0.009) for CCA patients. Additionally, univariate and multivariate analysis displayed that LINC00261 an independent prognostic factor in CCA patients. Yes Knockdown of LINC00261 expression in RBE and QBC939 cell lines inhibited cell proliferation, migration and invasion property and increased cell apoptosis and the EMT progression. 31812439 LINC00261 LncRNA Homo sapiens Myocardial Infarction coronary heart disease tissues with MI Interaction(miR-522-3p/TNRC6A ) Western Blot//Transfection//Flow Cytometry//FISH//qRT-PCR//MTT//Luciferase Report Assay LINC00261 and TNRC6A were upregulated, while miR-522-3p was downregulated in coronary heart disease tissues with MI.LINC00261 targets miR-522-3p in cardiomyocytes. In addition, miR-522-3p targets TNRC6A in cardiomyocytes. TNRC6A regulates cell viability and apoptosis of cardiomyocytes after MI, and TNRC6A-induced MI can be reversed by overexpression of miR-522-3p. Yes Knockout of LINC00261 can increase the viability of cardiomyocytes and inhibit cell apoptosis. 34239606 LINC00261 LncRNA Homo sapiens Endometriosis endometriosis tissues Interaction[LINC00261/miR-132-3p/BCL2L11] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LINC00261 was significantly downregulated in endometriosis tissues and our study indicated that it suppresses proliferation and invasion of endometriosis cells functionally in vitro. These data defined LINC00261/miR-132-3p/BCL2L11 regulatory networks may be a novel therapeutic target for endometriosis. Yes LINC00261 was significantly downregulated in endometriosis tissues and our study indicated that it suppresses proliferation and invasion of endometriosis cells functionally in vitro. 31105834 LINC00174 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-320/S100A10 axis] Western Blot//Flow Cytometry//qRT-PCR//CCK8//RIP//BrdU//Transwell Assay We demonstrated that LINC00174 expression in HCC clinical samples was significantly increased and this was correlated with higher T stage. We demonstrate that LINC00174 functions as a sponge for miR-320, increases the expression level of oncogene S100A10 in HCC. We demonstrated that LINC00174 expression in HCC clinical samples was significantly increased and this was correlated with higher T stage. Yes Its overexpression remarkably accelerated proliferation and metastasis of HCC cells while reduced apoptosis. Accordingly, knockdown of it suppressed the malignant phenotypes of HCC cells. 32128852 LINC00174 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-378a-3p/SSH2 axis and the TGF-β/SMAD pathway) qRT-PCR//RNA Pull-Down//Western Blot We found that LINC00174 was upregulated in OS tissues and cells. In conclusion, LINC00174 promotes OS cellular malignancy and tumorigenesis via the miR-378a-3p/SSH2 axis and the TGF-β/SMAD pathway, which might provide a novel insight for OS treatment. Yes LINC00174 knockdown repressed OS cell growth. 34222341 LINC00174 LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[miR-152-3p/SLC2A1 axis] RNA Pull-Down//Western Blot//ISH//Wound Healing Assay//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//ELISA//Transwell Assay LINC00174 was overexpressed in glioma tissues and cell lines.LINC00174 could interact with miR-152-3p/SLC2A1 axes. The miR-152-3p inhibitor or the SLC2A1 overexpression could rescue the anti-tumor effect of LINC00174 knockdown on glioma cells. Yes LINC00174 knockdown inhibited cell proliferation, migration, invasion and glycolysis of glioma cells, and LINC00174 exerted a tumorigenesis role. Moreover, downregulation of LINC00174 also inhibited tumor volume and delayed the tumor growth in vivo. 31492194 LINC00174 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Regulation[LINC00174/miR-1910-3p/TAZ pathway] CCK8//qRT-PCR//RNA Pull-Down//Luciferase Report Assay We observed that increased expression of LINC00174 in CRC tissues and cells in comparison to their corresponding controls.Taken together, our study discovered the oncogenic role of LINC00174 in clinical specimens and cellular experiments, showing the potential LINC00174/miR-1910-3p/TAZ pathway. Moreover, the aberrant overexpression of LINC00174 indicated the poor prognosis of CRC patients. Yes Silence of LINC00174 was able to repress CRC cell growth in vitro and in vivo. 29729381 LIFR-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells regulation[miR-942-5p/ZNF471 axis] qRT-PCR Overexpression of miR-942-5p caused a reduction of LIFR-AS1 in NSCLC cells.we provide first evidence for the involvement of the LIFR-AS1/miR-942-5p/ZNF471 axis in NSCLC invasion and metastasis. LIFR-AS1 may represent a novel target for the treatment of NSCLC. Yes Functionally, LIFR-AS1 overexpression inhibited NSCLC cell migration and invasion, whereas LIFR-AS1 silencing yielded an opposite effect. In vivo studies confirmed that LIFR-AS1 overexpression suppressed lung metastasis of NSCLC cells. 32489316 LIFR-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Epigenetics(hypermethylated) qRT-PCR//Luciferase Report Assay We identified a novel hypermethylated lncRNA, LIFR-AS1, that was downregulated and associated with tumorigenesis, metastasis, and poor prognosis in CRC. Functional assays revealed that LIFR-AS1 could competitively bind to hsa-miR-29b-3p, and repressed colon cancer cell proliferation, colony formation and invasion. LIFR-AS1 also inhibited tumor growth in a mouse xenograft model of CRC. We identified a novel hypermethylated lncRNA, LIFR-AS1, that was downregulated and associated with tumorigenesis, metastasis, and poor prognosis in CRC. High methylation burden of LIFR-AS1 indicated a poor survival of CRC patients. Yes Functional assays revealed that LIFR-AS1 could competitively bind to hsa-miR-29b-3p, and repressed colon cancer cell proliferation, colony formation and invasion. LIFR-AS1 also inhibited tumor growth in a mouse xenograft model of CRC. 36316703 LIFR-AS1 LncRNA Homo sapiens Osteosarcoma human mononuclear cells Interaction(miR-29a/NFIA axis) CCK8//qRT-PCR Then, the results of the high-throughput microarray assay showed that LIFR-AS1 was highly expressed and miR-29a was lowly expressed. Furthermore, LIFR-AS1 was identified as a miR-29a sponge, and NFIA was validated as a direct target of miR-29a. Yes Functional assays demonstrated that knockdown of exosomal LIFR-AS1 could attenuate the promotion effects of macrophages-derived exosomes on osteosarcoma cell progression and miR-29a inhibition could reserve the effect of LIFR-AS1-knockdown exosomes. 33794884 LIFR-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Interaction(miR-31-5p/SIDT2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Tube Formation Assay//qRT-PCR//ELISA//Colony Formation Assay//Invasion Assay The tumor size and lymphatic metastasis were correlated with LIFR-AS1 overexpression. LIFR-AS1 and SIDT2 expressions were suppressed in PTC tissues, while that of miR-31-5p was elevated in PTC tissues.This paper demonstrates that LIFR-AS1/miR-31-5p/SIDT2 axis modulated the development of PTC. The tumor size and lymphatic metastasis were correlated with LIFR-AS1 overexpression. Yes Overexpressed LIFR-AS1 suppressed tumorigenesis in vivo. LIFR-AS1 was negatively correlated with miR-31-5p. LIFR-AS1 sponged miR-31-5p to upregulate SIDT2, thereby inhibiting the viability, proliferation, migration, invasion, and the secretion of vascular endothelial growth factor (VEGF) of PTC cells and angiogenesis of human umbilical vein endothelial cells (HUVECs). 34781815 LIFR-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC cell lines and tumors Interaction(miRNA-150-5p/ VEGFA/Akt signaling) Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay . In this study, we determined that PC cell lines and tumors exhibit increased LIFR-AS1 expression that correlates with larger tumor size, lymph node metastasis, and more advanced TNM stage. Mechanistically, we found that METTL3 induced m6A hyper-methylation on the 3' UTR of LIFR-AS1 to enhance its mRNA stability and LIFR-AS1 could directly interact with miR-150-5p, thereby indirectly up-regulating VEGFA expressions within cells. . In this study, we determined that PC cell lines and tumors exhibit increased LIFR-AS1 expression that correlates with larger tumor size, lymph node metastasis, and more advanced TNM stage. Yes Functionally, loss-of-function studies indicated that LIFR-AS1 knockdown decreased the proliferation, migration, and invasion of PC cells in vitro. 34658294 LIFR-AS1 LncRNA Homo sapiens stomach carcinoma GC tissues and cells interaction[sponging miR-4698,MEK/ERK pathway] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Decreased lncRNA LIFR?AS1 expression was observed in GC tissues and cells.The process was mediated via miR‑4698, MTUS1 and the MEK/ERK pathway. Yes Upregulated lncRNA LIFR?AS1 inhibited GC cell proliferation, migration and invasion. 33355363 LIFR-AS1 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues and cells Expression [highly expressed] In Vivo Experiment//Western Blot//qRT-PCR//MTT//cell invasion assay//Cell Cycle Assay//EdU Staining The results showed significant (p < 0.05) upregulation of LncRNA-LIFR-AS1 in thyroid cancer tissues and cells. However, silencing of LncRNA-LIFR-AS1 inhibited the viability and proliferation of human thyroid cancer cells inducing G2/M cell cycle arrest.  Yes The thyroid cancer cells exhibited remarkably lower invasion and migration under transcriptional knockdown of lncRNA-LIFR-AS1 which was also associated with downregulation of MMP-2 and MMP-9 expression. 33927978 LIFR-AS1 LncRNA Homo sapiens Ovarian Neoplasms SOC patients Expression(lower expressed) Western Blot//ISH//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay LIFR-AS1 was lowly expressed in SOC, which was correlated with the poor prognosis of SOC patients. LIFR-AS1 overexpression promoted the expressions of cleaved caspase-3 and E-cadherin while suppressing the malignant behaviors (proliferation, migration, and invasion) of SOC cells, the expressions of PCNA, N-cadherin, and Snail. Besides, silencing LIFR-AS1 exerted the effects opposite to overexpressed LIFR-AS1. Low expression of LIFR-AS1 in SOC was associated with the tumor size, clinical stage, lymph node metastasis, and distant metastasis. Yes LIFR-AS1 overexpression promoted the expressions of cleaved caspase-3 and E-cadherin while suppressing the malignant behaviors (proliferation, migration, and invasion) of SOC cells, the expressions of PCNA, N-cadherin, and Snail. Besides, silencing LIFR-AS1 exerted the effects opposite to overexpressed LIFR-AS1. 35778954 LIF-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] FISH//Transwell Assay The expression level of Lnc-LIF-AS in cervical cancer tissues was higher than that in normal tissues and the expression level of Lnc-LIF-AS was positively correlated with the level of LIF. Yes The overexpression of Lnc-LIF-AS can promote cell proliferation, migration and invasion in cervical cancer cells, and the core function domain of this lncRNA was located in the overlapping a 3'-UTR base sequence of LIF mRNA. 31085454 LICN00520 LncRNA Homo sapiens Melanoma melanoma tissues regulation[miR-125b-5p/EIF5A2 axis] RNA Pull-Down//ChIP//Wound Healing Assay//CCK8//qRT-PCR//EdU Staining//Transwell Assay We found that LICN00520 was found to be overexpressed in melanoma tissue.We also showed that LICN00520 promotes the growth and metastasis of melanoma in vivo through regulating miR-125b-5p/EIF5A2 axis. High expression of LICN00520 is a risk factor for the prognosis of melanoma patients. Yes LINC00520 promotes the proliferation, invasion and migration of melanoma cells. 32466797 LICN00518 LncRNA Homo sapiens Melanoma melanoma tissue Regulation[miR-204-5p/AP1S2 axis] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//ChIP We found that LICN00518 was significantly upregulated in melanoma tissue, and high LICN00518 level was an independent risk factor for melanoma patients.LICN00518 exerted its role by decoying miR-204-5p to upregulate Adaptor Related Protein Complex 1 Sigma 2 Subunit (AP1S2) expression. Yes LICN00518 promoted the invasion and migration of melanoma cells. 31712557 LHFPL3-AS2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(SFPQ /TXNIP) qRT-PCR//Luciferase Report Assay//RNA Pull-Down We showed that LHFPL3-AS2 is a novel lncRNA, significantly decreased in NSCLC tissues. Moreover, downregulation of LHFPL3-AS2 reduced its specific interaction with SFPQ, resulting in more SFPQ binding to the promoter of TXNIP and causing the transcriptional repression of TXNIP, thus finally promoting the migration and invasion of NSCLC cells. Furthermore, LHFPL3-AS2 was shown to be regulated by EGR1 under hypoxia. LHFPL3-AS2 was further validated in an additional 93 paired samples of NSCLC. Low levels of LHFPL3-AS2 expression were highly correlated with poor overall survival, TNM stage, and metastasis of NSCLC patients. Yes Enhanced expression of LHFPL3-AS2 inhibited NSCLC invasion and metastasis in vitro and in vivo. 35101541 LHFPL3-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction(miR-362-5p/CHSY1 Pathway) qRT-PCR//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay LHFPL3-AS1 was highly expressed in OSCC tissues and cell lines. LHFPL3-AS1 was the competing endogenous RNA (ceRNA) for miR-194-5p to enhance CHSY1 expression. LHFPL3-AS1 level was correlated with survival rate. Yes LHFPL3-AS1 knockdown suppressed OSCC proliferation, migration and invasion. 33833527 LHFPL3-AS1 LncRNA Homo sapiens Melanoma melanoma tissues and cells regulation[LHFPL3-AS1/miR-580-3p/STAT3] Northern Blot//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Invasion Assay Data from our work suggested that LHFPL3-AS1 expression was markedly elevated in melanoma tissues and cells. Our study revealed a novel positive feedback loop LHFPL3-AS1/miR-580-3p/STAT3 in melanoma, which might contribute to finding potential therapeutic targets for melanoma. Of note, patients with melanoma with high level of LHFPL3-AS1 were burdened with unfavorable prognosis. Yes Functionally, it has been revealed that LHFPL3-AS1 exerted pro-growth, pro-invasion, and pro-EMT functions in melanoma. 32753471 LHFPL3 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC cells and tissues Interaction(microRNA-143-5p/homeobox A6 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay It was discovered that LHFPL3-AS1 and HOXA6 expression was elevated while the miR-143-5p level was depleted in radiation-resistant NPC cells and NPC tissues. The silenced LHFPL3-AS1 or augmented miR-143-5p repressed the proliferation, colony formation, migration and invasion of radiation-resistant NPC cells, while accelerated cell apoptosis in vitro. Silenced LHFPL3-AS1 hindered tumor growth in vivo. MiR-143-5p deletion reversed the effects of reduced LHFPL3-AS1; while HOXA6 upregulation reversed the effects of enriched miR-143-5p. LHFPL3-AS1 sponged miR-143-5p that targeted HOXA6. It is concluded that the down-regulated LHFPL3-AS1 retards the development of radiation-resistant NPC cells via sponging miR-143-5p to modulate HOXA6. This study reveals novel therapeutic targets for NPC treatment. Yes The silenced LHFPL3-AS1 or augmented miR-143-5p repressed the proliferation, colony formation, migration and invasion of radiation-resistant NPC cells, while accelerated cell apoptosis in vitro. Silenced LHFPL3-AS1 hindered tumor growth in vivo. 35176945 LGALS8-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(miR-125b-5p/SOX12 Feedback) Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Invasion Assay The lncRNA LGALS8-AS1 was highly expressed in breast cancer and associated with poor survival. It upregulated SOX12 via competing as a competing endogenous RNA (ceRNA) for sponging miR-125b-5p and acted on the PI3K/AKT signaling pathway to promote the metastasis of breast cancer. Furthermore, SOX12, in turn, activated LGALS8-AS1 expression via direct recognition of its sequence binding enrichment motif on the LGALS8-AS1 promoter, thereby forming a positive feedback regulatory loop. The lncRNA LGALS8-AS1 was highly expressed in breast cancer and associated with poor survival. Yes LGALS8-AS1 functioned as an oncogenic lncRNA that promoted the metastasis of breast cancer both in vitro and in vivo. 34745940 LETR1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues Regulation[Wnt/β-catenin signaling] RNA Pull-Down//Western Blot//Co-IP//qRT-PCR//RIP//Colony Formation Assay We found that a FOXO1-related lncRNA, LINC01197, was significantly decreased in PDAC malignant tissues and that its low expression predicted poor prognosis.Mechanistically, LINC01197 was found to bind to β-catenin and inhibit Wnt/β-catenin signaling activity by disrupting β-catenin binding to TCF4 in PDAC cells. Yes Moreover, LINC01197 was mainly localized in the nucleus and inhibited PDAC cell proliferation both in vitro and in vivo. 31027497 LET LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and MDA-MB-231 cells Expression[lower expressed] Flow Cytometry//qRT-PCR//MTT//Transwell Assay The expression of lncRNA LET was reduced in breast cancer tissues and MDA-MB-231 cells. Yes Overexpression of lncRNA LET resulted in the inhibition of cell proliferation, invasion and migration ability, and promotion of cell apoptosis (p<0.05). 30280783 LIFR-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction[miR-197-3p] IHC//Western Blot//ISH//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, we found that LIFR-AS1 was significantly down-regulated in both tissues and cell lines.Moreover, LIFR-AS1 was observed to up-regulate suppressor of fused gene (Sufu) expression by competitively binding to miR-197-3p in breast cancer cells. Yes Additionally, LIFR-AS1 knockdown promoted tumor growth in vivo 31127025 LIFR-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric tumor tissues and cells Interaction(miR-29a-3p/COL1A2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Colony Formation Assay//CCK8//Luciferase Report Assay//IHC//Bioinformatics Analysis//Transwell Assay The expression levels of LIFR-AS1 were significantly increased in gastric tumor tissues and cells, while the expression levels of miR-29a-3p were decreased. The expression of miR-29a-3p was negatively correlated with the expression of LIFR-AS1 in gastric cancer tumor tissues. Bioinformatics analyses and integrated experiments revealed that LIFR-AS1 elevated the expression of COL1A2 through sponging miR-29a-3p, which further resulted in the progression of gastric tumor. Yes Knocking down of LIFR-AS1 inhibited proliferation, invasion and migration of gastric tumor cells, and induced apoptosis of gastric tumor cells. 33407453 LIMD1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC samples and cells regulation[LIMD1,hnRNP U] RNA Pull-Down//CCK8//qRT-PCR//RIP//EdU Staining Moreover, long noncoding RNA (lncRNA) LIMD1 antisense RNA 1 (LIMD1-AS1) was downregulated in NSCLC samples and cell lines. Mechanistically, LIMD1-AS1 stabilized LIMD1 mRNA through interacting with hnRNP U. Rescue experiments suggested that LIMD1-AS1 repressed NSCLC progression through LIMD1. Yes LIMD1-AS1 knockdown abrogated NSCLC cell growth in vitro and in vivo. 32239804 LINC00152 LncRNA Mus musculus acute myocardial infarction serum Regulation(Smad7) CCK8//qRT-PCR//Transwell Assay Serum level of LINC00152 was elevated in AMI patients. ROC curves demonstrated the diagnostic potential of LINC00152 in AMI (95% CI: 0.806-0.940, p = 0.034). In myocardial tissues collected from AMI mice, LINC00152 level was higher than those collected from mice of the sham group. LVEF and FS markedly decreased in AMI mice overexpressing LINC00152 on the 4th week of AMI modeling. After knockdown of LINC00152 in primary cardiac fibroblasts, proliferative and migratory abilities were declined, which were abolished by Smad7 intervention. ROC curves demonstrated the diagnostic potential of LINC00152 in AMI (95% CI: 0.806-0.940, p = 0.034). Yes After knockdown of LINC00152 in primary cardiac fibroblasts, proliferative and migratory abilities were declined, which were abolished by Smad7 intervention. 34900025 LINC00173.v1 LncRNA Homo sapiens lung squamous cell carcinoma SQC tissues regulation[miR-511-5p,VEGFA ] ISH//qRT-PCR//Luciferase Report Assay//RIP LINC00173.v1 was specifically upregulated in SQC tissues, which predicted poorer overall and progression-free survival in SQC patients.Our results further revealed that LINC00173.v1 promoted the proliferation and migration of vascular endothelial cells and the tumorigenesis of SQC cells by upregulating VEGFA expression by sponging miR-511-5p. LINC00173.v1 was specifically upregulated in SQC tissues, which predicted poorer overall and progression-free survival in SQC patients. Yes Overexpression of LINC00173.v1 promoted, while silencing LINC00173.v1 inhibited the proliferation and migration of vascular endothelial cells and the tumorigenesis of SQC cells in vitro and in vivo. 32473645 LINC00173 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC and adjacent breast tissues regulation[miR-490-3p] qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay TNBCs expressed increased levels of LINC00173 relative to normal breast tissues.Altogether, LINC00173 functions as an oncogene in TNBC through antagonization of miR-490-3p. TNBC patients with high tumoral LINC00173 levels had a lower recurrence-free survival and overall survival rate than those with low LINC00173 expression. Yes Silencing of LINC00173 inhibited the proliferation, colony formation, and invasion of TNBC cells, whereas overexpression of LINC00173 exerted opposite effects. 32058222 LINC00173 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-765/NUTF2 axis] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay LINC00173 expression was elevated in glioma tissues and cells.Our research demonstrated that LINC00173 promotes glioma progression through targeting miR-765/NUTF2 axis. LINC00173 high expression predicted poor prognosis. Yes Loss of LINC00173 inhibited proliferation, migration and invasion. 32848473 LINC00173 LncRNA Homo sapiens Prostatic Neoplasms PCa specimens and cell lines regulation[LINC00173/miR-338-3p/Rab25 pathways] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay We observed that the expression of LINC00173 and Rab25 was distinctly upregulated in both PCa specimens and cell lines, while miR-338-3p expression was significantly down-regulated. The discovery of the LINC00173/miR-338-3p/Rab25 pathways provided new thinking for the treatments of PCa. High LINC00173 expression was associated with Gleason score, preoperative PSA level and reduced patient survivals. Yes Functional assays revealed that knockdown of LINC00173 suppressed the proliferation, migration and invasion of PCa cells, and promoted apoptosis. 33015770 LINC00165 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines interaction[STAT3 ] qRT-PCR In the present study, our results showed that LINC00165 was upregulated in GC tissues and cell lines and high expression of LINC00165 was correlated with tumor-node-metastasis stage, invasion depth, and overall survival of GC patients. Mechanistically, we revealed that LINC00165 functioned as a scaffold for interaction with Polycomb Repressive Complex 2 to promote the epithelial-mesenchymal transition in GC cells. In the present study, our results showed that LINC00165 was upregulated in GC tissues and cell lines and high expression of LINC00165 was correlated with tumor-node-metastasis stage, invasion depth, and overall survival of GC patients. Yes Functional assays showed that LINC00165 knockdown inhibited the proliferation, migration and invasion of GC cells and LINC00165 overexpression stimulated their proliferation, migration and invasion. 30448060 LINC00161 LncRNA Homo sapiens Carcinoma, Hepatocellular serum-derived exosomes from HCC patients and the supernatants of HCC cell lines Interaction(miR-590-3p/ROCK axis) qRT-PCR//Western Blot High levels of LINC00161 were detected in both serum-derived exosomes from HCC patients and the supernatants of HCC cell lines and were significantly associated with poor survival. Mechanistic study revealed that exosome-carried LINC00161 directly targeted miR-590-3p and induced its downstream target ROCK2, finally activating growth/metastasis-related signals in HCC. High levels of LINC00161 were detected in both serum-derived exosomes from HCC patients and the supernatants of HCC cell lines and were significantly associated with poor survival. Yes Functional study demonstrated that exosomal LINC00161 derived from HCC-cells were significantly associated with enhanced proliferation, migration, and angiogenesis in HUVECs in vitro, all of which were effectively inhibited when LINC00161 was sliced with shRNA in HCC-cells. In vivo experiment showed that LINC00161 loss inhibited tumorigenesis and metastasis of HCC. 33414518 LINC00160 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer cells Regulation(RCAN1) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//ChIP Silence of LINC00160 inhibited proliferation and promoted the apoptosis of prostate cancer cells, retarded the glycolysis of prostate cancer cells. By acting as a transcription activator, STAT3 induced LINC00160 expression, which regulated RCAN1 transcription epigenetically via binding to EZH2. Mechanically, LINC00160 mediated prostate cell proliferation and metabolism by repressing RCAN1 expression. In summary, LINC00160 may function as the novel marker for prostate cancer diagnosis and therapy. Yes Silence of LINC00160 inhibited proliferation and promoted the apoptosis of prostate cancer cells, retarded the glycolysis of prostate cancer cells. 35067783 LINC00158 LncRNA Rattus norvegicus Spinal Cord Injuries SCI model rats Regulation( LC3-II/LC3-I, Beclin-1, and p62 ) In Vivo Experiment The results showed that the expression of LINC00158 decreased and apoptotic cells increased in the SCI model rats. Meanwhile, we found the upregulated LC3-II/LC3-I, Beclin-1, and p62 in the SCI rats. After OGD treatment, the expression of LINC00158 decreased significantly and the apoptosis of spinal cord neurons increased. OGD treatment resulted in upregulation of LC3-II/LC3-I and Beclin-1 and downregulation of p62 in primary spinal cord neurons, which could be eliminated by overexpression of LINC00158. 3-Methyladenine and chloroquine (autophagy inhibitor) reversed the inhibitory effect of LINC00158 overexpression on apoptosis of primary spinal cord neurons. Yes The results showed that the expression of LINC00158 decreased and apoptotic cells increased in the SCI model rats. Meanwhile, we found the upregulated LC3-II/LC3-I, Beclin-1, and p62 in the SCI rats. 36588354 LINC00115 LncRNA Homo sapiens Lung Neoplasms tumor tissues and cells Interaction(miR-607/ITGB1 pathway) CCK8//qRT-PCR//Transwell Assay LINC00115 was highly expressed in tumor tissues and cells. Investigation to its molecular mechanism revealed that LINC00115 functioned as a competitive endogenous RNA (ceRNA), regulating the expression of ITGB1 by sponging miR-607 to affect tumor growth. The LINC00115/miR-607/ITGB1 signaling axis might be a novel therapeutic target in lung cancer. Yes LINC00115 promoted the malignant properties of tumor cells. 34643030 LIN28B-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung Interaction[IGF2BP1 ] CCK8//RNA Pull-Down//RIP//Microarray "In addition to the known let-7-LIN28B regulation loop, our results further revealed a let-7-independent Cis-regulator of LIN28B: LIN28B-AS1. LIN28B-AS1 is a CT long non-coding RNA (CT-lncRNA). It altered the messenger RNA stability of LIN28B by directly interacting with another CT protein IGF2BP1 but not with LIN28B and constituted a novel regulation network. In sum, we identify that LIN28B is an ""epi-driver"" of LUAD and clarify a new lncRNA-activated mechanism of LIN28B, which provide new candidate targets for precise anticancer therapy in the future." Yes In vitro and In vivo experiments confirmed that the activation of LIN28B could promote the proliferation and metastasis of LUAD cells and can influence cell cycle, DNA damage repair, and genome instability. 30353165 LINC00115 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue regulation[LINC00115/miR-489-3p axis ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay In this study, we discovered that LINC00115 was significantly overexpressed in CRC, and its overexpression predicted poor patient outcomes. Deeper understanding of the LINC00115/miR-489-3p axis might provide potential therapeutic targets against CRC metastasis. In this study, we discovered that LINC00115 was significantly overexpressed in CRC, and its overexpression predicted poor patient outcomes. Yes Downregulation of LINC00115 markedly inhibited CRC cell proliferation, increased cell apoptosis, and suppressed cell migration and invasion. 33193658 LINC00115 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Interaction(miR-212-5p/FZD5/Wnt/β-catenin axis) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//cell invasion assay//Colony Formation Assay Our results showed that LINC00115 was significantly up-regulated in prostate cancer tissues, which was significantly associated with a poor prognosis for prostate cancer patients. In addition, LINC00115 served as a competing endogenous RNA (ceRNA) through sponging miR-212-5p to release Frizzled Family Receptor 5 (FZD5) expression. The expression of miR-212-5p was noticeably low in tumour tissues, and FZD5 expression level was down-regulated with the knockdown of LINC00115. Knockdown LINC00115 inhibited the Wnt/β-catenin signalling pathway by inhibiting the expression of FZD5. Yes Functional studies showed that knockdown LINC00115 inhibited cell proliferation and invasion. 34697900 LINC00114 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction[suppressed miR-133b] RNA Pull-Down//Co-IP//qRT-PCR//RIP//Luciferase Report Assay//ChIP Data showed that LINC00114 was highly expressed, whereas miR-133b was downregulated in the CRC tissues and cells.These results demonstrated that LINC00114 suppressed miR-133b expression via EZH2/DNMT1-mediated methylation of its promoter region, indicating that LINC00114 might be a potential novel target for CRC diagnosis and treatment. Yes In vitro, silencing LINC00114 inhibited cell proliferation and impeded cell cycle at the G1/S phase by upregulating miR-133b. In vivo, LINC00114 knockdown reduced tumor growth. 31921641 LINC00052 LncRNA Homo sapiens Breast Neoplasms BC tissues Interaction(miR-145-5p /TGFBR2 ) Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Invasion Assay The expression levels of LINC00052 were found to be significantly higher in BC tissues compared with those in the adjacent normal tissues.LINC00052 was mainly expressed in the cytoplasm and was considered to bind with microRNA (miR)-145-5p based on various databases. Notably, the high expression levels of LINC00052 led to the low expression levels of miR-145-5p and high expression levels of TGF-β receptor II (TGFBR2). Yes Downregulation of LINC00052 expression in vitro significantly suppressed the proliferation, migration and invasion of BC cells. 33777194 LINC00052 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(miR-548p/Notch2/Pyk2 ) RNA Pull-Down//Western Blot//ISH//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay High LINC00052 expression was observed in breast cancer tissues and cells. MiR-548p, a target gene of LINC00052, partially rescued the effects of LINC00052 on proliferation, migration, and invasion of MCF7. Notch2 was the target of miR-548p and LINC00052 could promote Notch2 expression. Moreover, the phosphorylation of proline-rich tyrosine kinase 2 (Pyk2), a downstream factor of Notch2, was increased by LINC00052, and a Pyk2 mutant could inhibit the cell migration and invasion induced by LINC00052 overexpression in MDA-MB-468 cells, which was similar to the function of the miR-548p mimic. Yes LINC00052 silencing inhibited the proliferation, migration, and invasion of MCF7 cells, and LINC00052 overexpression produced the opposite results. 35918619 LINC00052 LncRNA Homo sapiens Glioma glioma tissues Interaction[downregulating IGF2] Western Blot//Wound Healing Assay//qRT-PCR//Cell Proliferation Assay//Transwell Assay LINC00052 expression was remarkably downregulated in glioma samples compared with that in normal brain samples.These results above suggest that LINC00052 could repress cell migration, invasion and proliferation in glioma through downregulating IGF2, which may offer a new therapeutic intervention for glioma patients. Yes Moreover, cell proliferation, cell invasion and cell migration in glioma were inhibited after overexpression of LINC00052 in vitro. 35116894 LINC00052 LncRNA Homo sapiens Glioma glioma tissues,cell lines Interaction[upregulating KLF6] qRT-PCR//Wound Healing Assay//Transwell Assay//Western Blot LINC00052 expression was remarkably downregulated in glioma samples compared with that in adjacent samples. These results suggested that LINC00052 could repress cell migration, invasion and proliferation in glioma through upregulating KLF6, which may offer a new therapeutic intervention for glioma patients. Yes Moreover, cell proliferation, invasion, and migration of glioma were inhibited after overexpression of LINC00052 in vitro. 31210314 LINC000466 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Interaction(miR-539-5p) Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay LINC00466 was significantly upregulated in TNBC and showed close association with the clinical features of patients, which indicates the development, and severity of patients. LINC00466 was significantly upregulated in TNBC and showed close association with the clinical features of patients, which indicates the development, and severity of patients. Yes LINC00466 functioned as a prognostic biomarker predicting the survival of patients and a tumor promoter improving the proliferation, migration, and invasion of TNBC cells through sponging miR-539-5p. 35216934 KCNQ1OT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-148a-3p/IGF1R Axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In our study, we first observed the expression level of KCNQ1OT1 was distinctly up-regulated in HCC tissues and cell lines compared with adjacent non-cancer tissues and normal liver cell line. In conclusion, our results shown the oncogenic role of KCNQ1OT1 in HCC by regulating the miR-148a-3p/IGF1R axis and may provide a new insight and a potential therapeutic target for HCC. And clinical results indicated that higher expression of KCNQ1OT1 was correlated with poor prognosis of patients with HCC. Yes Next, functional studies revealed that knockdown of KCNQ1OT1 induced apoptosis and repressed proliferation, migration and invasion of HCC cells. In addition, knockdown of KCNQ1OT1 suppressed xenograft tumor growth in vivo. 33349156 HSD11B1-AS1 LncRNA Homo sapiens skin melanoma MM tissues Expression(lower expressed) Transfection//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Colony Formation Assay//Invasion Assay//Transwell Assay Using data from The Cancer Genome Atlas database, novel lncRNA 11β-hydroxysteroid dehydrogenase type 1-antisense RNA 1 (HSD11B1-AS1) was identified, which was significantly downregulated in malignant melanoma and its downregulation was significantly associated with poor clinicopathological characteristics, including advanced T and pathological stage, Clark level, Breslow depth and ulceration and worse prognosis. Functional enrichment showed significantly enriched pathways in IFN-γ and -α response, TNF-α signaling via NF-κB and IL-2/STAT-5 and IL-6/JAK/STAT-3 signaling. Using data from The Cancer Genome Atlas database, novel lncRNA 11β-hydroxysteroid dehydrogenase type 1-antisense RNA 1 (HSD11B1-AS1) was identified, which was significantly downregulated in malignant melanoma and its downregulation was significantly associated with poor clinicopathological characteristics, including advanced T and pathological stage, Clark level, Breslow depth and ulceration and worse prognosis. Yes Moreover, cell experiments in vitro, including Cell Counting Kit-8, colony formation, wound healing and Transwell assay, suggested that overexpression of HSD11B1-AS1 significantly inhibited melanoma cell proliferation, migration and invasion. 34992686 ILF3-DT LncRNA Homo sapiens Colonic Neoplasms COAD tissue Interaction(miR-619-5p/CAMK1D Axis) In Vivo Experiment//Western Blot//Transfection//Migration Assay//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay The results showed that the expression of ILF3-AS1 was significantly higher in COAD tissue than in normal adjacent samples, and this conclusion was confirmed in the available public datasets. After further exploring the mechanisms, we found that ILF3-AS1 serves as a competitive endogenous RNA of mir-619-5p. It can bind to mir-619-5p and reduce its expression, thus regulating the target gene CAMK1D. Yes After ILF3-AS1 knockdown, the proliferation of COAD cell lines SW480 and HT29 was significantly inhibited. At the same time, the apoptosis was increased, and the invasion and migration abilities were decreased. 33737811 IL21-AS1 LncRNA Homo sapiens Lupus Erythematosus, Systemic patients with SLE Expression(lower expressed) Flow Cytometry//qRT-PCR//Genotyping IL21-AS1 was expressed in the nucleus of CD4+ T and B cells, but its expression was decreased in patients with SLE. Furthermore, we observed a significant negative correlation between IL21-AS1 expression and disease activity in patients with SLE (n = 53, p < 0.05). Yes IL21-AS1 expression was positively correlated with mRNA levels of IL-2 but not IL-21, and it was associated with the proportion of activated T follicular regulatory (Tfr) cells. 34895341 IL1R1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Regulation[Wnt/β-catenin signaling pathway] qRT-PCR We identified that AC007271.3 was up-regulated and positively correlated with advanced clinical stage, lymph node metastasis, poor histological differentiation and unfavorable prognosis.Our data indicated that AC007271.3 could promote cell proliferation, invasion and inhibit cell apoptosis of OSCC via the Wnt/β-catenin signaling pathway, which might provide a novel therapeutic approach for OSCC. We identified that AC007271.3 was up-regulated and positively correlated with advanced clinical stage, lymph node metastasis, poor histological differentiation and unfavorable prognosis. Yes Overexpression of AC007271.3 remarkably promoted cell proliferation in vitro and in vivo, induced cell migration, invasion and inhibited apoptosis in vitro, while knockdown of AC007271.3 attenuated cell proliferation, migration, invasion and induced apoptosis. 31759044 IL1R1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck regulation[miR-125b-2-3p/Slug] RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC//ChIP Taken together, these results suggested that the classical NF-κB pathway-activated AC007271.3 regulates EMT by miR-125b-2-3p/Slug/E-cadherin axis to promote the development of OSCC, implicating it as a novel potential target for therapeutic intervention in this disease. Yes Our previous studies confirmed that dysregulated function of long non-coding RNA (lncRNA) AC007271.3 was associated with a poor prognosis and overexpression of AC007271.3 promoted cell proliferation, migration, invasion, and inhibited cell apoptosis in vitro, and promoted tumor growth in vivo. 33311454 IL-17RA-1 LncRNA Homo sapiens Sepsis THP-1 cells Interaction(miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR In addition, IL-17RA-1 could target binding to miR-7847-3p and inhibit its expression, and miR-7847-3p could also bind to PRKCG. Our experiments demonstrate that IL17-RA-1 attenuates the sepsis response through the miR-7847-3p/MAPK pathway, and this competing endogenous RNA (ceRNA) network may be a potential approach to predict and combat sepsis. Yes Compared with control, si-IL-17RA-1 significantly inhibited the cell viability and migration ability of THP-1, and levels of proinflammatory factors IL-6, IL-1β, and TNF-α secreted were markedly decreased, and the expression of IL-17RA-1, PRKCG, p-MEKK1, and p-JNK were markedly reduced. 36274974 IKBKBAS LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines Interaction(miR-4741/IKKβ/NF-κB.) Northern Blot//Western Blot//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay The upregulated IKBKBAS functioned as a competing endogenous RNA (ceRNA) via competing with IKKβ mRNA for binding miR-4741, consequently leading to upregulation and activation of IKKβ, and ultimately activation of NF-κB. Yes Herein, we reported a novel lncRNA IKBKBAS that activated NF-κB in lung adenocarcinoma (LUAD) by upregulating IKKβ, a key member of NF-κB signaling pathway, thereby promoting the metastasis of LUAD both in vitro and in vivo. 34702815 IGKJ2-MALLP2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues regulation[ miR-1911-3p/p21] qRT-PCR//Luciferase Report Assay The results of this study showed that the expression of IGKJ2-MALLP2 was reduced in LSCC tissues and displayed close relationships with tumor stage, lymph node metastasis, and clinical stage. As indicated from the mentioned findings, IGKJ2-MALLP2, which mediates p21 expression by targeting miR-1911-3p, was capable of regulating LSCC progression and could act as an underlying therapeutic candidate to treat LSCC. The results of this study showed that the expression of IGKJ2-MALLP2 was reduced in LSCC tissues and displayed close relationships with tumor stage, lymph node metastasis, and clinical stage. Yes As revealed by the results of in vitro experiments, IGKJ2-MALLP2 overexpression could restrict tumor growth and blood vessel formation in a xenograft model of LSCC. 32639636 IGHA1 LncRNA Homo sapiens Multiple Myeloma MM patient samples and cell lines Expression(highly expressed) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay LncRNA AL was highly expressed in MM patient samples and cell lines, and was significantly correlated with the disease stage of patients. Western blot analysis showed that knockdown of lncRNA AL significantly inhibited the expression of CDK2 and cyclin D1 and promoted the expression of cyclin suppressor p21. LncRNA AL was highly expressed in MM patient samples and cell lines, and was significantly correlated with the disease stage of patients. Yes . Knockdown of lncRNA AL significantly inhibited the proliferation and colony formation of MM cells and induced cell cycle arrest in G0/G1 phase. Knockdown of lncRNA AL significantly inhibited the proliferation of MM cells in nude mice. 35280429 IGFL2-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[IGFL2-AS1/miR-802/ARPP19 axis] qRT-PCR We found that IGFL2-AS1 was highly expressed in GC tissues and cell lines.Therapies targeting the IGFL2-AS1/miR-802/ARPP19 axis can potentially improve GC treatment. Yes Knockdown of IGFL2-AS1 suppressed GC cell proliferation, migration, and invasion in vitro. 31943339 IGFL2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues and cells Interaction(HIF-1α/CA9 ) qRT-PCR//Colony Formation Assay//Western Blot We discovered that IGFL2-AS1 was highly upregulated in CRC tumor tissues and cells. Mechanistic studies demonstrated that IGFL2-AS1 upregulated the CA9 level by affecting the degradation pathway of HIF-1α, which elucidates its pro-proliferative effect in CRC. The lncRNA IGFL2-AS1 mediated the inhibition of HIF-1α degradation in CRC and increased CA9 expression, thereby promoting CRC progression. Yes IGFL2-AS1 can functionally promote CRC cell proliferation, migration, and invasion in vitro and accelerate CRC occurrence in vivo. 36537608 IGFL2-AS1 LncRNA Homo sapiens Colonic Neoplasms colon adenocarcinoma (COAD) tissue and cell lines (HCT116, HCT8, HCT129, and SW480) Expression(highly expressed) qRT-PCR//Western Blot The lncRNA IGFL2-AS1 was highly expressed in colon adenocarcinoma (COAD) tissue and cell lines (HCT116, HCT8, HCT129, and SW480). Western blot results showed that the inhibition of IGFL2-AS1 could significantly reduce the N-cadherin, HIF1A and KRAS protein expression, yet increase the E-cadherin protein level. IGFL2-AS1 was also positively correlated with M0 macrophages, M2 macrophages, and neutrophils but negatively correlated with CD4+ memory T cells and CD8+ T cells. The COAD patients with high IGFL2-AS1 were associated with a worse prognosis. Yes Meanwhile, the knockdown of IGFL2-AS1 could significantly suppress the proliferation and invasion of COAD cells. 34377016 IGFL2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[ AC006262.5-miR-7855-5p-BPY2C axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Interestingly, we found that AC006262.5 is significantly upregulated in HCC tissues compared with adjacent normal tissues (Fig. 1B). In addition, our results revealed that AC006262.5 bound to and regulated miR-7855-5p, a tumor-suppressive miRNA, in HCC. Moreover, our data show that AC006262.5 regulates the expression of BPY2C via miR-7855-5p. Finally, we found that AC006262.5 and miR-7855-5p formed a regulatory loop. Upregulation of AC006262.5 resulted in decreased expression of miR-7855-5p, and downregulation of miR-7855-5p further facilitated the expression of AC006262.5. Yes Here, we identified an enriched long non-coding RNA, AC006262.5, associated with HCC, that promoted the proliferation, migration, and invasiveness of HCC cells, both in vitro and in vivo. 32956593 IGFL2-AS1 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC cells and tissues Interaction(SATB1/Wnt/β-catenin signaling pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay IGFL2-AS1 was significantly up-regulated in TSCC cells and tissues, and IGFL2-AS1 knockdown inhibited cell proliferation, migration, invasion and EMT in TSCC. Moreover, IGFL2-AS1 functioned as a competing endogenous RNA (ceRNA) to sponge miR-1224-5p and thereby modulated SATB homeobox 1 (SATB1) expression. Additionally, SATB1 activated the Wnt/β-catenin signaling pathway in TSCC cells and IGFL2-AS1 regulated the Wnt/β-catenin signaling pathway and TSCC progression via elevating SATB1 expression. Yes IGFL2-AS1 was significantly up-regulated in TSCC cells and tissues, and IGFL2-AS1 knockdown inhibited cell proliferation, migration, invasion and EMT in TSCC. 34085359 IGFBP4-1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues regulation[JAK/STAT signaling pathway] Western Blot//CCK8//qRT-PCR//Cell Apoptosis Assay//Cell Cycle Assay The results showed that IGFBP4-1 was overexpressed in bladder cancer tissues compared with that in normal bladder tissues, and its expression level was positively correlated with poor prognosis in bladder cancer patients. In conclusion, IGFBP4-1 promoted bladder cancer progression by activating the JAK/STAT signaling pathway. The results showed that IGFBP4-1 was overexpressed in bladder cancer tissues compared with that in normal bladder tissues, and its expression level was positively correlated with poor prognosis in bladder cancer patients. Yes Overexpression of IGFBP4-1 markedly promoted cell proliferation and cell cycle progression, and inhibited cell apoptosis, while knockdown of IGFBP4-1 notably suppressed the proliferation, promoted cell apoptosis, and induced cell cycle arrest at the G0/G1 phase. 32760196 IGF2BP2-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissuses Regulation(Wnt/β-catenin pathway) qRT-PCR//Transwell Assay In comparison with the normal tissue samples, OSCC showed higher expression of IGF2BP2-AS1 . Western blotting showed that expressions of β-catenin, Cyclin D1, Bcl-2, and MMP2 were downregulated, whereas Bax was upregulated following knockdown of IGF2BP2-AS1. The inhibitory effect of knockdown of IGF2BP2-AS1 on migration could be partially reversed by the Wnt/β-catenin pathway stimulator LiCl. High expression of IGF2BP2-AS1 was associated with poor survival in OSCC patients. Yes Further in vitro functional tests demonstrated that downregulation of IGF2BP2-AS1 in Cal27 and SCC9 cells significantly inhibited cell proliferation and migration, leading to cell-cycle arrest and cell apoptosis. 34637162 IGF2-AS LncRNA Homo sapiens Stomach Neoplasms GC tissues interaction[ miR-195/CREB1 axis] Flow Cytometry//qRT-PCR//RIP//Western Blot Our data revealed that IGF2-AS was upregulated in GC tissues and predicted poor prognosis. In conclusion, our study suggested that IGF2-AS knockdown suppressed glycolysis and facilitated apoptosis in GC cells at least partly through sponging miR-195 and modulating CREB1 expression, highlighting a novel therapeutic strategy for GC treatment. Yes IGF2-AS knockdown hampered glycolysis and accelerated apoptosis of GC cells. 34321174 IGF2-AS LncRNA Homo sapiens Breast Neoplasms breast cancer tissues, cell lines, and plasma regulation[ PI3K/AKT/mTOR signaling pathway] qRT-PCR//ChIP//RIP//Western Blot Here, we found that IGF2 antisense RNA (IGF2-AS) was significantly decreased in breast cancer tissues, cell lines, and plasma.Further investigation revealed that IGF2-AS inhibited the expression of its sense-cognate gene IGF2 in an epigenetic DNMT1-dependent manner, resulting in the inactivation of downstream oncogenic PI3K/AKT/mTOR signaling pathway. Patients with low IGF2-AS were more likely to develop larger tumor size and later clinical stage. Yes Overexpression of IGF2-AS evidently inhibited the proliferation and induced apoptosis of MCF-7 and T47D cells in vitro, as well as retarded tumor growth in vivo. 33175607 IGF2-AS LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Interaction(microRNA-520h/cyclin-dependent kinase inhibitor 1A signaling pathway) qRT-PCR//Western Blot Our results showed that IGF2-AS expression was significantly down-regulated in HCC cells and tissues; lower IGF2-AS expression was significantly associated with poor prognosis of HCC patients; IGF2-AS sponged microRNA-520h (miR-520h) to up-regulate IGF2-AS expression, and miR-520h over-expression or cyclin-dependent kinase inhibitor 1A (CDKN1A) silencing reversed IGF2-AS reduced aggressive behaviors of HCC cells. Yes IGF2-AS over-expression inhibited the viability, colony formation, invasion, and migration, while promoted apoptosis in vitro, and inhibited HCC xenograft growth in vivo; 34516353 IL6-AS1 LncRNA Homo sapiens Pulmonary Disease, Chronic Obstructive patients Interaction(miR-149-5p/ IL-6) RNA Pull-Down//ISH//Transfection//qRT-PCR//FISH//RIP//Luciferase Report Assay We identified a novel long noncoding RNA (lncRNA), interleukin 6 antisense RNA 1 (IL6-AS1), which is upregulated in this disease and is associated with airway inflammation. Mechanistically, cytoplasmic IL6-AS1 acts as an endogenous sponge by competitively binding to the microRNA miR-149-5p to stabilize IL-6 mRNA. Yes We found that IL6-AS1 promotes the expression of inflammatory factors, especially interleukin (IL) 6. 34323408 ILF3-DT LncRNA Homo sapiens Retinoblastoma RB tissues and cell lines regulation[miR-132-3p/SMAD2 axis] qRT-PCR In the present study, our work revealed that the lncRNA ILF3-AS1 was increased in both RB tissues and cell lines.Collectively, these data indicate that ILF3-AS1 is involved in RB progression through the miR-132-3p/SMAD2 axis, providing a novel and promising biomarker that can be used for the treatment of RB. Yes Repression of ILF3-AS1 suppressed both RB cell proliferation and invasion in vitro. ILF3-AS1 also promoted tumor growth in vivo. 32407730 IGF2-AS LncRNA Homo sapiens gastric adenocarcinoma GAC tissues Interaction[sponging miR-503] Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Colony Formation Assay//Transwell Assay Our study found that lncRNA insulin growth factor 2 antisense (IGF2-AS) is up-regulated in gastric adenocarcinoma (GAC) tissues and correlated with poor prognosis in patients with GAC.Taken together, our results demonstrated that IGF2-AS takes important regulatory parts in GAC development by functioning as a ceRNA to regulate SHOX2 via sponging miR-503. Yes In vivo tumorigenicity assay showed that knockdown of IGF2-AS significantly reduced tumor volume. 31183590 ILF3-DT LncRNA Homo sapiens Nasopharyngeal carcinoma nasopharyngeal tissues Expression[highly expressed] qRT-PCR lncRNA ILF3-AS1 expression was significantly up-regulated in the 68 nasopharyngeal carcinoma tissue samples compared to their adjacent normal tissue samples. Increased lncRNA ILF3-AS1 level was related to the advanced tumor node metastasis stage and the metastasis of nasopharyngeal carcinoma. Also, increased lncRNA ILF3-AS1 indicated poor prognosis of nasopharyngeal carcinoma patients. Yes Inhibition of lncRNA ILF3-AS1 reduced proliferation, invasion and migration of nasopharyngeal carcinoma cells. 32962500 IQANK1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues and cell lines Expression[highly expressed] qRT-PCR In the present study, it was determined that, in comparison with paired para-tumorous tissues or normal esophageal epithelial cells, FAM83H-AS1 expression in cancer tissues and cell lines was markedly upregulated. Furthermore, FAM83H-AS1 expression was significantly elevated in patients with ESCC and lymph node metastasis or a late TNM stage, while no association with any other clinicopathological characteristics was detected.Furthermore, the overall and disease-free survival, as assessed by the Kaplan-Meier method, were significantly shortened in patients with high FAM83H-AS1 expression. Yes A functional study then uncovered that knockdown of FAM83H-AS1 significantly suppressed the proliferation and migration of ESCC cells. 33154766 IQANK1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[Wnt/β-catenin pathway] CCK8//qRT-PCR//Western Blot In the present study, our results confirmed that lncRNA FAM83H-AS1 expression was overexpressed in HCC tissues relative to the adjacent normal tissues.Moreover, we found that the downregulating expression of lncRNA FAM83H-AS1 inhibited Wnt/β-catenin pathway by reducing β-catenin and WNT1 expression in HCC cells. Furthermore, higher lncRNA FAM83H-AS1 expression significantly associated with tumor size and vascular invasion in patients with HCC. The Kaplan-Meier methods and log rank test demonstrated that increased lncRNA FAM83H-AS1 expression associated with shorter patient overall survival compared to lower lncRNA FAM83H-AS1 expression in patients with HCC. Yes Moreover, function assays by CCK-8 cell proliferation and transwell cell migration and invasion assays showed that the knockdown of lncRNA FAM83H-AS1 significantly inhibited cell proliferation, migration, and invasion ability in HCC. 31599410 IQANK1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues,cell lines Expression[Expression[highly expressed]-expression] CCK8//qRT-PCR First, qRT-PCR was used to detect the expression of lncRNA FAM83H-AS1 in OC tissues and cell lines. The results showed that lncRNA FAM83H-AS1 was significantly Expression[Expression[up-expression]-expression]-regulated in both OC tissues and OC cells when compared with normal controls. Yes "The re_x0002_sults showed that Si-FAM83H-AS1 transfection significantly inhibited the expression of lncRNA FAM83H-AS1 in vitro. (Figure 3A)." 31210291 IQANK1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues,cell lines Expression[highly expressed] qRT-PCR//RNA Pull-Down//RIP First of all, the obvious upregulation of FAM83H-AS1 was identified by qRT-PCR in OC tissues, especially in metastatic tissues, as well as in OC cell lines. Yes Through loss-of-function assays, we validated the inductive effect of FAM83H-AS1 in OC cell metastasis and radioresistance. 30831080 IQANK1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissue, cell lines Expression[highly expressed] qRT-PCR In our results, the expression of FAM83H-AS1 was obviously elevated in bladder cancer tissue samples and bladder cancer cell lines compared with adjacent normal tissue samples and normal bladder epithelial cell lines, respectively. In addition, high expression of FAM83H-AS1 was associated with advanced clinical stage and the presence of muscularis invasion and served as an independent poor prognostic factor for overall survival in patients with bladder cancer. Yes The loss-of-function study showed that silencing FAM83H-AS1 expression suppressed cell proliferation, migration, and invasion and induced cycle arrest at G0/G1 phase. 30537032 IQANK1 LncRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues,cell lines regulation[c-Myc-mediated ULK3] Western Blot//Tunel//Colony Formation Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//IHC//Transwell Assay High expression of FAM83H-AS1 was found in 82 BCa tissues and in BCa cell lines compared to the normal ones.This study evidenced that FAM83H-AS1 upregulates ULK3 expression through the transcription factor c-Myc and promotes the progression of BCa. Yes FAM83H-AS1 downregulation in T24 and BK10 cells inhibited viability, colony formation, migration, invasion, and angiogenesis of BCa cells and increased cell apoptosis. 33289601 IQANK1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma tumor tissues and serum of patients with PDAC Interaction(FAM83H/Wnt/β-catenin signaling) CCK8//qRT-PCR//Wound Healing Assay FAM83H-AS1 was highly expressed in the tumor tissues and serum of patients with PDAC, and was correlated with shorter survival. Importantly, FAM83H protein manifested the similar malignant functions as that of FAM83H-AS1 in PDAC cells, and could bind to β-catenin. Specifically, FAM83H could decrease the ubiquitylation of β-catenin, and accordingly activated the effector genes of Wnt/β-catenin signaling. FAM83H-AS1 was highly expressed in the tumor tissues and serum of patients with PDAC, and was correlated with shorter survival. Yes FAM83H-AS1 significantly promoted the proliferation, invasion and metastasis of PDAC cells, by protecting FAM83H mRNA from degradation. 36171592 IQANK1 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Interaction[E6-p300 pathway] CCK8//RNA-seq Interestingly, FAM83H-AS1 was found overexpressed in HPV-16 positive cervical cancer cell lines in an HPV-16 E6-dependent manner but independently of p53 regulation. Furthermore, FAM83H-AS1 was found to be regulated through the E6-p300 pathway. Yes Knockdown of FAM83H-AS1 by siRNAs decreased cellular proliferation, migration and increased apoptosis. 30842470 IQANK1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells and tissues regulation[miR-136-5p/metadherin axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Our data show that the FAM83H-AS1 levels are increased in human TNBC cells and tissues. Together, our results demonstrate that FAM83H-AS1 functions as an oncogenic lncRNA that regulates miR-136-5p and MTDH expression during TNBC progression, and suggest that targeting the FAM83H-AS1/miR-136-5p/MTDH axis may serve as a novel therapeutic target in TNBC. Yes Importantly, our in vivo data show that FAM83H-AS1 also promotes tumor growth in TNBC mouse xenografts. 32074085 IQANK1 LncRNA Homo sapiens Prostatic Neoplasms cell lines regulation[miR-15a/CCNE2 Axis] ChIP//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, the results validate that AR signaling is involved in upregulating FAM83H-AS1 expression in PCa cells.Mechanically, we found that FAM83H-AS1 plays its roles through sponging miR-15a to promote CCNE2 expression. These findings indicate that FAM83H-AS1 is a novel diagnostic and therapeutic marker for PCa. Yes Loss-of-function assays demonstrate that FAM83H-AS1 acts as an oncogene in PCa by modulating cell proliferation, cell cycle, and migration. 33614501 IPW LncRNA Homo sapiens Carcinoma, Ductal DCIS cells Interaction( IPW-miR-29c-ID2 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//Cell Proliferation Assay//Cell Cycle Assay//IHC//ChIP We identified lncRNA IPW as a novel tumor suppressor critical for inhibiting DCIS growth.Ectopic expression of IPW in DCIS cells strongly inhibited cell proliferation, colony formation and cell cycle progression while silencing IPW in primary breast cells promoted their growth. Additionally, orthotropic implantation of cells with ectopic expression of IPW exhibited decreased tumor growth in vivo. Mechanistically, IPW epigenetically enhanced miR-29c expression by promoting H3K4me3 enrichment in its promoter region. Yes We identified lncRNA IPW as a novel tumor suppressor critical for inhibiting DCIS growth.Ectopic expression of IPW in DCIS cells strongly inhibited cell proliferation, colony formation and cell cycle progression while silencing IPW in primary breast cells promoted their growth. Additionally, orthotropic implantation of cells with ectopic expression of IPW exhibited decreased tumor growth in vivo. 35078502 INHBA-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[AKT1 pathway] qRT-PCR//RIP The present study identified INHBA-AS1 as a kind of lncRNA with high expression in CRC tissues and cells.In summary, LncRNA INHBA-AS1 contributes to CRC progression through AKT1 pathway, and provides a new mechanism to regulate CRC development, as well as a potential target for treating CRC. Yes Functionally, NHBA-AS1 downregulation in CRC cells suppressed CRC cell proliferation as well as colony formability. 33090398 ILF3-DT LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(miR-4429/RAB14 ) RNA Pull-Down//Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, we found that ILF3-AS1 was highly expressed in breast cancer tissues and cells. ILF3-AS1 bound with miR-4429 in breast cancer cells. Moreover, RAB14 was a downstream target of miR-4429, and miR-4429 expression was negatively correlated with RAB14 or ILF3-AS1 expression in breast cancer tissues. Yes ILF3-AS1 silencing inhibited breast cancer cell proliferation, migration and invasion, and promoted cell apoptosis. 33525948 ILF3-DT LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Expression [highly expressed] RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Colony Formation Assay//Transwell Assay ILF3-AS1 and EZH2 increased, whereas CDKN2A reduced in CRC tissues and cells. ILF3-AS1 and EZH2 expression was linked to Dukes stage, distant metastasis, vascular invasion, and lymph node metastasis of CRC patients. Yes Depleted ILF3-AS1 or reduced EZH2 suppressed proliferation, migration, colony-formation, and invasion ability, as well as facilitated apoptosis of CRC cells and attenuated the tumor growth in CRC mice. 34141456 ILF3-DT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression(highly expressed) qRT-PCR//MeRIP//RNA Pull-Down//RIP Here, we found that ILF3-AS1 expression was significantly elevated in HCC tissues and also associated with prognosis of patients with HCC.Mechanistically, ILF3-AS1 associated with ILF3 mRNA and inhibited its degradation. ILF3-AS1 increased ILF3 m6A level via recruiting N6-methyladenosine (m6A) RNA methyltransferase METTL3. Moreover, IFL3-AS1 enhanced the interaction between ILF3 mRNA and m6A reader IGF2BP1. Here, we found that ILF3-AS1 expression was significantly elevated in HCC tissues and also associated with prognosis of patients with HCC. Yes Functional assays demonstrated that knockdown of ILF3-AS1 expression resulted in the suppression of proliferation, migration and invasion in HCC cells, whereas overexpression of ILF3-AS1 exerted opposite effects. Additionally, knockdown of IFL3-AS1 attenuated HCC tumorigenesis and metastasis in vivo. 34491544 ILF3-DT LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma cells Interaction(miR-628-5p/MEIS2 axis) qRT-PCR RT-qPCR analysis revealed that ILF3-AS1 was significantly upregulated in hepatocellular carcinoma cells. Luciferase reporter, RNA pull down and RIP assays were used to investigate the relationship between ILF3-AS1 and downstream target genes. ILF3-AS1 competed with meis homeobox 2 (MEIS2) for miR-628-5p in hepatocellular carcinoma cells. ILF3-AS1 elevated the levels of key proteins on the Notch pathway. Yes The hepatocellular carcinoma cell viability was suppressed by silenced ILF3-AS1. Transwell and wound healing assays showed that ILF3-AS1 downregulation inhibited cell invasion and migration. The levels of proteins associated with epithelial-mesenchymal transition (EMT) process and the Notch pathway were detected by western blot analysis. 34053876 ILF3-DT LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Regulation[miR-212/SOX5 axis] qRT-PCR In this study, we showed that ILF3-AS1 expression was significantly up-regulated in both osteosarcoma tissues and cell lines. Clinical assays revealed that higher expression of ILF3-AS1 was associated with advanced clinical stage, distant metastasis and shorter overall survival. Yes Functional investigations showed that knockdown of ILF3-AS1 suppressed the proliferation, migration and invasion of osteosarcoma cells, and promoted apoptosis. 30819403 ILF3-DT LncRNA Homo sapiens Uterine Cervical Neoplasms human CC tissues and cells Interaction(miR‑454‑3p / PTEN) Western Blot//Bioinformatics Analysis//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Survival Analysis//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The present study demonstrated that ILF3‑AS1 expression was significantly downregulated in human CC tissues and cells compared with adjacent tissues (ANTs) and normal cervical epithelial cells (NCEs), respectively. In conclusion, the present study indicated that ILF3‑AS1 inhibited CC cell proliferation and migration, and promoted CC cell apoptosis by inhibiting epithelial‑mesenchymal transition, and ILF3‑AS1 overexpression partially reversed the inhibitory effect of miR‑454‑3p on PTEN expression. Patients with CC with high ILF3‑AS1 expression displayed higher survival rates compared with patients with low ILF3‑AS1 expression. Yes Compared with the negative control (NC) group, ILF3‑AS1 overexpression significantly inhibited CC cell viability and migration, but significantly increased CC cell apoptosis. Moreover, ILF3‑AS1 overexpression significantly upregulated E‑Cadherin expression levels, but significantly downregulated N‑Cadherin and snail family transcriptional repressor 1 expression levels compared with the NC group. 34080029 IGF2-AS LncRNA Homo sapiens Prostatic Neoplasms Pca tissues, cell lines Regulation[ IGF2AS/IGF2 axis] CCK8//qRT-PCR//Transwell Assay IGF2AS was downregulated in both PCa cell lines and human PCa tumors. IGF2 was downregulated by IGF2AS overexpression. Conversely, IGF2 upregulation revered the suppressing function of IGF2AS on PCa proliferation and invasion. Yes In VCaP and PC3 cells, lentivirus-induced IGF2AS overexpression suppressed cancer cell proliferation and invasion in vitro, and xenograft development in vivo. 30423304 IGF2-AS LncRNA Homo sapiens Endometriosis endometriotic cells Interaction(miR-370-3p/IGF2 axis/PI3K/AKT/mTOR) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Invasion Assay//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Furthermore, insulin-like growth factor 2 antisense RNA (IGF2-AS) was uncovered to positively regulate IGF2 expression and enhanced proliferative, migratory, and invasive abilities of endometriotic cells. Mechanistically, miR-370-3p was found to bind with IGF2-AS and IGF2. IGF2-AS competitively bind with miR-370-3p to upregulate IGF2. Furthermore, IGF2-AS was revealed to activate the PI3K/AKT/mTOR signaling pathway through targeting miR-370-3p/IGF2 axis. Yes Furthermore, insulin-like growth factor 2 antisense RNA (IGF2-AS) was uncovered to positively regulate IGF2 expression and enhanced proliferative, migratory, and invasive abilities of endometriotic cells. 36508036 KCNQ1OT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(microRNA‑504/CDK16) qRT-PCR In this study, we demonstrated that the expression of KCNQ1OT1 was abnormally increased in HCC tissues. Additionally, we found that KCNQ1OT1 exerted its effects partly by relying on the microRNA‑504 (miR‑504)‑mediated regulation of cyclin‑dependent kinase 16 (CDK16), in addition to the regulation of the glycogen synthase kinase 3β (GSK3β)/β‑catenin/Bcl‑2 signaling pathway. The ectopic high expression of KCNQ1OT1 was associated with liver cirrhosis, a larger tumor size, an advanced TNM stage, and a worse overall survival and tumor?free survival. Yes For the first time, to the best of our knowledge, we report that KCNQ1OT1 knockdown results in a decreased cell viability and colony formation ability, and an increased rate of apoptosis in vitro. The results from our in vivo results demonstrated that KCNQ1OT1 silencing attenuated tumor growth by impairing cell proliferation. 29532864 HULC LncRNA Homo sapiens Colonic Neoplasms CRC tissues and adjacent NCTs,cell lines(HCT116，SW480，HT30,LoVo) Interaction[ miR-613 ] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay HULC was markedly up-regulated in 76.1% (51/67) of colon cancer tissues compared to the adjacent normal colon tissues. The findings in the study suggested that HULC might inhibit the tumor growth through miR-613 dependent RTKN modulation. Yes HULC knockdown suppressed the proliferation, DNA synthesis and metastasis of human colon cancer cells in vitro. 30551459 HULC LncRNA Homo sapiens Carcinoma, Hepatocellular cell line regulation[miR-377-5p/HIF-1α pathway] qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay The mRNA and protein expression levels of HULC were markedly increased, whereas the mRNA expression levels of miR-377-5p were decreased in HCC cell lines. In summary, our in vitro and in vivo findings confirmed HULC to play a role in the progression of HCC, with the underlying mechanism possibly involving the miR-377-5p/HIF-1α pathway. Yes HepG2 cell proliferation and invasion were suppressed in the Sh-HULC group, while miR-377-5p showed the opposite.Importantly, the in vivo experiments indicated that down-regulation of HULC could inhibit tumor growth. 33209874 HULC LncRNA Homo sapiens Carcinoma, Hepatocellular liver cancer cells Interaction(miR-3200-5p/ATF4 Axis) qRT-PCR Here, we show that knockdown of HULC increases ferroptosis and oxidative stress in liver cancer cells. We also found changes in some related miRNAs in cells treated with HULC siRNA. Differential miRNA expression levels were determined with the use of high-throughput sequencing and prediction target genes identified using bioinformatics analysis. HULC was found to function as a ceRNA of miR-3200-5p, and miR-3200-5p regulates ferroptosis by targeting ATF4, resulting in the inhibition of proliferation and metastasis within HCC cells. In summary, these findings illuminate some of the molecular mechanisms through which downregulation of HULC induces liver cancer cell ferroptosis by targeting the miR-3200-5p/ATF4 axis to modulate the development of hepatocellular carcinoma. Yes Here, we show that knockdown of HULC increases ferroptosis and oxidative stress in liver cancer cells. 35615577 HULC LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Oral cancer tissues and their adjacent normal tissues,cell lines (SCC9, SCC15, SCC25, CAL27) Expression[highly expressed] CCK8//qRT-PCR//Western Blot Analysis of 30 pairs of clinical oral cancer tissues and their adjacent normal tissues revealed that HULC expression was higher in the cancer tissues than in the normal tissues.We also measured HULC levels in four OSCC cell lines (SCC15, SCC25, SCC9 and CAL27), which revealed that HULC expression was markedly up-regulated in the cancer cell lines relative to that in a normal oral keratinocyte cell line. Yes We report that HULC was abnormally up-regulated in oral cancer tissues and OSCC cell lines, and that suppression of HULC expression in OSCC cells not only inhibited the proliferation, drug tolerance, migration and invasion of the cancer cells, but also increased their apoptosis rate. Notably, in a mouse xenograft model, HULC depletion reduced tumorigenicity and inhibited the epithelial-to-mesenchymal transition process. 30677230 HULC LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines regulation[miR-372-3p/HMGB1 signalling axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our results revealed elevated HULC and decreased miR-372-3p expression in both osteosarcoma tissues and cell lines.Our study is the first to demonstrate that HULC may act as a ceRNA to modulate HMGB1 expression by competitively sponging miR-372-3p, leading to the regulation of osteosarcoma progression, which provides new insight into osteosarcoma diagnosis and treatment. Yes Overexpression of HULC or knockdown of miR-372-3p promoted osteosarcoma cell proliferation, migration and invasion and induced cell apoptosis. 32188407 HULC LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells Regulation(PTEN/AKT-PI3K-mTOR) qRT-PCR//Western Blot The expression of HULC was obviously higher in osteosarcoma tissues and cells compared with normal control. Furthermore, HULC increased the activity of AKT-PI3K-mTOR pathway by blocking PTEN in osteosarcoma cells. LY294002 inhibited the phosphorylation of AKT, mTOR, and PI3K. Overexpressing HULC enhanced cell migration and invasion of SAOS-2 cells and MG63 cells, while LY294002 reversed the effects. Yes Moreover, cell proliferation, migration, and invasion were inhibited by HULC knockdown in osteosarcoma cells. HULC overexpression markedly increased osteosarcoma cell proliferation and tumor size in vivo. 36213832 HULC LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cell lines regulation[miR-218/TPD52 Axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay HULC expression was upregulated in cervical cancer cell lines, and HULC promoted cervical cancer cell proliferation, migration and invasion.HULC promotes cervical cancer cell proliferation, migration and invasion via miR-218/TPD52 axis. Yes HULC expression was upregulated in cervical cancer cell lines, and HULC promoted cervical cancer cell proliferation, migration and invasion. 32103980 HULC LncRNA Homo sapiens Glioma glioma tissues and cells Interaction(FOXM1/AGR2/HIF-1α axis) RNA Pull-Down//Western Blot//Tunel//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Microarray// In Vivo Experiment//IHC//ChIP HULC was upregulated in GBM tissues and GSCs, which may promote the progression of glioma. In addition, HULC further stabilized FOXM1 expression in GSCs through ubiquitination, while FOXM1 activated AGR2 transcription to promote HIF-1α expression. Moreover, HULC promoted the glycolysis and stemness of GSCs through its regulation of the FOXM1/AGR2/HIF-1α axis, consequently exacerbating the occurrence and development of glioma. Yes On the other hand, silencing of HULC reduced the stemness, inhibited the proliferation, and promoted the apoptosis and differentiation of GSCs. 35013529 HULC LncRNA Homo sapiens Glioblastoma U87 cells regulation[RRAS expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay The results of present study suggest that lncRNA HULC promotes GBM cell proliferation, invasion, and migration by regulating RRAS expression, suggesting that RRAS may be a potential biomarker or therapeutic target for this cancer. Yes Overexpression of HULC led to increased cell proliferation, invasion, and migration. 32606802 HULC LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells regulation[PI3K/AKT and Wnt/β-catenin pathways] CCK8//qRT-PCR//Cell Apoptosis Assay//Western Blot We discovered that HULC and miR-106a had relative high expression levels in PTC tissues and cells.Moreover, HULC overexpression boosted PI3K/AKT and Wnt/β-catenin pathways activities via raising miR-106a expression. Yes HULC overexpression enhanced TPC-1 cells viability and cell proliferative, migratory and invasive abilities. Silencing HULC induced TPC-1 cell apoptosis. 31878795 HULC LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues,blood Regulation[Wnt/β-catenin signaling pathway ] CCK8//qRT-PCR//Transwell Assay//Western Blot Highly expressed in the tissues and serum of pancreatic cancer patients, HULC showed good clinical value in distinguishing between patients with pancreatic cancer, patients with benign pancreatic diseases and healthy subjects.HULC is an effective marker for the diagnosis and prognosis of pancreatic cancer, which may affect the biological function of pancreatic cancer cells through the Wnt/β-catenin signaling pathway. Patients with low expression of HULC had a significantly higher 3-year overall survival (OS) and 5-year OS than those with high expression. T staging, M staging, vascular invasion, and HULC were independent prognostic factors affecting the 3-year OS of patients with pancreatic cancer. Yes Inhibition of HULC expression prevented the proliferation and invasion of pancreatic cancer cells, promoted apoptosis, and inhibited the expression of Wnt/β-catenin signaling pathway-related proteins, β-catenin, c-myc, and cyclin D1. 31857775 HULC LncRNA Homo sapiens Pancreatic Neoplasms PDAC cells regulation[EMT signaling] qRT-PCR//Luciferase Report Assay//Transwell Assay//Western Blot We previously verified that lncRNA HULC is up-regulated in PDAC cells and the intercellular transfer of HULC by EVs can promote PDAC cell invasion and migration through the induction of epithelial-mesenchymal transition (EMT). These results provide mechanistic insights into the development of PDAC by demonstrating that miR-622, as a miRNA downregulated by TGF-β, could target HULC and suppress invasion and migration by inhibiting EMT signaling via EV transfer. Yes We previously verified that lncRNA HULC is up-regulated in PDAC cells and the intercellular transfer of HULC by EVs can promote PDAC cell invasion and migration through the induction of epithelial-mesenchymal transition (EMT). 32656089 HULC LncRNA Homo sapiens Bone Neoplasms neoplasm cell lines Expression[highly expressed] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay Compared to the human normal bone cell line, we found lncRNA HULC was over-expressed in all 6 bone neoplasm cell lines, and we finally chose HT1080 and Saos-2 cell lines, which possessed the highest lncRNA HULC expression level, for the subsequent studies. We then observed that the expression level of lncRNA HULC was negatively correlated with overall survival rate of bone neoplasm patients, which means that lncRNA HULC has prognostic value in patients with bone neoplasms. Yes LncRNA HULC can promote the tumorigenesis of bone neoplasms through increasing the proliferation, invasion, and migration abilities and the expression level of EMT-related factors. 30120220 HULC LncRNA Homo sapiens ovarian carcinoma ovarian carcinoma tissue Expression[highly expressed] CCK8//qRT-PCR In this study, we observed that circular RNA-ITCH was downregulated, while lncRNA HULC was upregulated in ovarian carcinoma. Yes Overexpression of circular RNA-ITCH resulted in inhibited, while overexpression of HULC promoted the proliferation of cells of ovarian cancer cell lines. 32046413 HULC LncRNA Homo sapiens Liver Neoplasms HCC tissues and paired adjacent liver tissues,blood Expression[highly expressed] Western Blot//qPCR//CCK8//Luciferase Report Assay//Transwell Assay HULC expression in serum exosomes of patients with HCC was higher than that in serum exosomes of healthy controls, and HULC levels were higher in liver cancer tissues than in tumor adjacent tissues. The expression of HULC in serum exosomes and liver cancer tissues correlated with the tumor-node-metastasis (TNM) classification, and HULC expression in tissues correlated with that in serum exosomes. Yes Upregulation of HULC promoted HCC cell growth and invasion and repressed apoptosis. 31558873 HULC LncRNA Homo sapiens Liver Neoplasms human liver tumors Interaction(p65/IkBkB/LC3II ) In Vivo Experiment//IHC//Western Blot//Migration Assay//qRT-PCR//Colony Formation Assay//Invasion Assay//IF HULC was identified as a lncRNA that is highly upregulated in human liver tumors. At a mechanistic level, HULC was able to promote the phosphorylation of p65 and IkBkB thus enhancing autophagy by increasing LC3II levels in a manner dependent upon the NF-κB pathway. HULC downregulation was also linked to impaired orthotopic HCC tumor growth in vivo. The link between HULC and autophagy may play a role in disease progression. Yes In vitro, HULC was able to promote HCC malignancy, although its excess overexpression also led robust autophagic induction, promoting the increased expression of autophagy-associated genes including LC3 and Beclin-1. 36213936 HULC LncRNA Homo sapiens lung squamous cell carcinoma LSCC tissues Regulation[ PTPRO/NF-κB signaling pathway] qRT-PCR Significantly decreased level of lncRNA HULC was observed in LSCC samples compared with adjacent tissues.Moreover, lncRNA HULC could promote the proliferation of LSCC cells by downregulating the expression PTPRO dependent on the phosphorylation and activation of nuclear factor-κB (NF-κB). The present study firstly shows strong evidence supporting a critical role of lncRNA HULC in promoting LSCC by regulating PTPRO/NF-κB signaling pathway, which provides new promising biomarkers for LSCC. Yes Moreover, lncRNA HULC could promote the proliferation of LSCC cells by downregulating the expression PTPRO dependent on the phosphorylation and activation of nuclear factor-κB (NF-κB). 31448453 HULC LncRNA Rattus norvegicus Myocardial Reperfusion Injury IR-injured myocardial tissue and the H/R-induced H9c2 cell Interaction(miR-377-5p -NLRP3/Caspase-1/IL-1β axis ) Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//ELISA We found that HULC was downregulated and miR-377-5p was upregulated in IR-injured myocardial tissue and the H/R-induced H9c2 cell. Strikingly, dual luciferase reporter assay showed that HULC was a sponge of miR-377-5p. Subsequently, mechanism experiments revealed that NLRP3/Caspase‑1/IL‑1β was a target axis of miR-377-5p. Finally, rescue assay suggested that HULC-miR-377-5p -NLRP3/Caspase‑1/IL‑1β axis regulated the apoptosis and inflammation of H/R-induced H9c2 cells. Yes In vitro, the protective effect of HULC overexpression on H9c2 cell viability and inflammation was offset by miR-377-5p silencing. 32674625 HSPA7 LncRNA Homo sapiens Glioblastoma GBM TISSUES Epigenetics(methylation) Western Blot//Transfection//FISH//Transwell Assay//IF We identified the m6A-modified pseudogene HSPA7 as a novel prognostic risk factor in GBM patients, with crucial roles in immunophenotype determination, stromal activation, and carcinogenic pathway activation. Yes We confirmed that HSPA7 promoted macrophage infiltration and SPP1 expression via upregulating the YAP1 and LOX expression of glioblastoma stem cells (GSCs) in vitro and in our clinical GBM tumor samples. We also confirmed that knockdown of HSPA7 might increase the efficiency of anti-PD1 therapy utilizing the GBO model, highlighting its potential as a novel target for immunotherapy. 34354698 HSPA7 LncRNA Homo sapiens Vascular Diseases Human aortic smooth muscle cells Interaction(miR-223 ) Migration Assay//qRT-PCR//RIP//RNA-seq//ELISA Among 380 RNAs differentially expressed between the plaque and control tissues, lncRNA HSPA7 was selected and confirmed to show upregulated expression upon oxLDL treatment. The effects of miR-223 inhibition and HSPA7 knockdown were also found in THP-1 cell-derived macrophages. The impact of HSPA7 on miR-223 was mediated in an AGO2-dependent manner. HSPA7 is differentially increased in human atheroma and promotes the inflammatory transition of vascular smooth muscle cells by sponging miR-223. Yes HSPA7 knockdown inhibited the migration of HASMCs and the secretion and expression of IL-1β and IL-6; however, HSPA7 knockdown recovered the oxLDL-induced reduction in the expression of contractile markers. Although miR-223 inhibition promoted the activity of Nf-κB and the secretion of inflammatory proteins such as IL-1β and IL-6, HSPA7 knockdown diminished these effects. 34857901 HULC LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[HULC/miR-2052/MET axis] Western Blot//CCK8//RIP//qRT-PCR//Luciferase Report Assay In the present study, we showed that HULC is overexpressed in HCC tissues, which correlates with an unfavorable prognosis in HCC patients.Our mechanistic studies showed that HULC works as a competing endogenous RNA for miR-2052, and that the MET receptor tyrosine kinase is a downstream target of miR-2052 in HCC. Furthermore, HULC inhibits miR-2052, thereby stimulating MET expression in HCC. Finally, MET overexpression reverses the effects of HULC depletion. In sum, our findings reveal a novel regulatory signaling cascade, the HULC/miR-2052/MET axis, which could potentially be exploited for therapeutic benefits in the treatment of HCC. Yes We also found that HULC promotes the proliferation, migration, and invasion of HCC cells in vitro, and xenograft tumor growth in vivo. 31645479 HULC LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissues Regulation[PI3K/Akt pathway] CCK8//qRT-PCR//MTT//Western Blot HULC expression level was increased in tumor tissues compared with adjacent healthy tissues in most patients.Serum level of HULC was higher in cancer patients than that in healthy control. LncRNA HULC overexpression can promote NSCLC cell proliferation and inhibit cell apoptosis by up-regulating sphingosine kinase 1 (SPHK1) and further induce the activation of its downstream PI3K/Akt pathway. Serum level of HULC was increased with the increased stage of primary tumor (T stage). Serum HULC can be used to accurately predict NSCLC and its prognosis. Yes HULC overexpression promoted tumor cell proliferation, but inhibited cell apoptosis. HULC overexpression also increased expression level of SPHK1 and phosphorylation level of Akt in NSCLC cell, but showed on significant effects on Akt expression. 30575912 IGF1R CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues and lung cancer cell lines Expression[lower expressed] qRT-PCR//RNA-seq The expression level of circ-IGF1R was notably lower in lung cancer tissues and lung cancer cell lines than in the adjacent normal tissues and cells (P < 0.0001). In addition, the expression level of circ-IGF1R was associated with larger tumors (T2/T3/T4) and lymph node metastasis (N1/ N2/N3) (P < 0.05). Yes The overexpression of circ-IGF1R significantly inhibited the invasion and migration of the lung cancer cells. 32107851 HULC LncRNA Homo sapiens Breast Neoplasms tumour tissues Expression[highly expressed] qRT-PCR HULC was significantly upregulated in tumour tissues compared to non-tumoural margins (P <0.001). Yes The HULC knockdown induced apoptosis and suppressed cellular migration in breast cancer cell lines. 33107484 IGF1R CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[PI3K/AKT pathway ] qRT-PCR//PCR//Western Blot Circ-IGF1R levels were found to be significantly upregulated in HCC tissues compared with levels in paired peritumoural tissues.Further investigation revealed that PI3K/AKT signalling pathway activation was involved in the oncogenic functions of circ-IGF1R in HCC. Our study suggests that circ-IGF1R may be a potential target for the prevention and treatment of HCC. The high expression levels of circ-IGF1R in HCC were associated with tumour size. Yes Moreover, knocking down circ-IGF1R with siRNA significantly attenuated cell proliferation and induced cell apoptosis and cell cycle arrest in vitro. 31377314 IGBP1-AS1 LncRNA Homo sapiens Breast Neoplasms cell lines and tissues of BC regulation[IGBP1-AS1/miR-24-1/ZIC3 loop] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP Significant down-regulation of IGBP1-AS1 was discovered in the cell lines and tissues of BC. LncRNA IGBP1-AS1/miR-24-1/ZIC3 axis as a loop can regulate the proliferation and invasion of BC cells. Yes With respect to its biological function, overexpression of IGBP1-AS1 had inhibitory effects on the invasion and proliferation of BC cells in vivo as well as in vitro. 32390766 IGBP1-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC samples and cell lines Interaction(miR-150-5p/ZEB1 ) qRT-PCR In the study, we found that IGBP1-AS1 was found to be significantly upregulated in the NPC samples and cell lines. Bioinformatics and reporter assays revealed an association between IGBP1-AS1 and miR-150-5p. The expression of ZEB1 was increased by the microRNA (miRNA) sequestering in human NPC. Yes The knockdown of IGBP1-AS1 impeded in-vitro proliferation of the NPC cells. 35402187 IFNG-AS1 LncRNA Homo sapiens Colonic Neoplasms serum and tissue samples Interaction(miR-627-3p) Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay IFNG-AS1 expression in both serum and tissue samples was elevated in patients. Serum IFNG-AS1 could diagnose colon adenoma and adenocarcinoma patients from the healthy control. Silence of IFNG-AS1 could be available for repressing cellular capacities via the sponge to miR-627-3p. Beyond that, downregulated expression of IFNG-AS1 may repress malignant progression of colon adenocarcinoma by regulating miR-627-3p. IFNG-AS1 was rised in colon adenocarcinoma and it was relevant to tumor size, TNM stage, and poor prognosis of patients. High tissue IFNG-AS1 was correlated with several clinical characteristics and a shorter overall survival time. Yes Silence of IFNG-AS1 could be available for repressing cellular capacities via the sponge to miR-627-3p. 34872454 IDH1-AS1 LncRNA Homo sapiens Glioma glioma tissues Expression[lower expressed] Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry The results from this work show that IDH1-AS1 is downregulated in the glioma tissues. Yes We found that when IDH1-AS1 is overexpressed cell proliferation is inhibited, cell cycle is arrested at the G1 phase, and the protein expression levels of cyclinD1, cyclinA, cyclinE, CDK2, and CDK4 are decreased. Moreover, we proved that overexpression of IDH1-AS1 inhibits the tumorigenesis of U251 cells, in vivo. 32990028 IDH1-AS1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Interaction[regulating ATG5-mediated autophagy] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Microarray//Cell Proliferation Assay//Colony Formation Assay//ChIP At first, the expression of IDH1-AS1 was identified to be upregulated in PCa samples and cell lines. Consequently, rescue assays demonstrated that IDH1-AS1 promoted proliferation and apoptosis in PCa via ATG5-induced autophagy. Yes Functionally, loss-of function assays revealed that silencing of IDH1-AS1 inhibited cell proliferation and induced cell apoptosis both in vitro and in vivo. 31570703 IDH1-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues and cell lines regulation[Enhancing IDH1 Enzyme Activity] Western Blot//CCK8//qRT-PCR//EdU Staining//Transwell Assay IDH1-AS1 expression was found to be significantly increased in prostate cancer tissues and cell lines.Our experiments revealed that the carcinogenic effects of IDH1-AS1 in prostate cancer may depend on a new molecular mechanism, which directly alters IDH1 enzyme activity. Yes IDH1-AS1 knockdown significantly inhibited the proliferation and migration of prostate cancer cells. 32884284 ID2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines and HCC tissues Regulation[HDAC8/ID2 pathway] qRT-PCR We found that ID2-AS1 expression decreased in metastatic HCC cell lines and HCC tissues, and lower ID2-AS1 expression predicted reduced overall survival in HCC patients. Taken together, our findings demonstrated that ID2-AS1 regulated adjacent ID2 transcription by manipulating chromatin modification and that the newly identified ID2-AS1/ID2 axis suppressed HCC metastasis by regulating EMT processes. We found that ID2-AS1 expression decreased in metastatic HCC cell lines and HCC tissues, and lower ID2-AS1 expression predicted reduced overall survival in HCC patients. Yes ID2-AS1 significantly suppressed the migration, invasion and metastasis of HCC cells in vitro and in vivo. 31730902 ICR LncRNA Mus musculus Atherosclerosis high fat diet-induced atherosclerosis model in mice Regulation(NF-κB signaling ) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//IF//RNA-seq//Luciferase Report Assay//Transwell Assay//ChIP In a high fat diet-induced atherosclerosis model in mice, ICR is upregulated in the development of atherosclerosis. Mechanistically, ICR stabilized the mRNA of ICAM1 in quiescent ECs; while under inflammatory stress, ICR upregulated ICAM1 in a nuclear factor kappa B (NF-κB) dependent manner. RNA-seq analysis showed pro-inflammatory targets of NF-κB were regulated by ICR. Furthermore, the chromatin immunoprecipitation assays showed that p65 binds to ICR promoter and facilitates its transcription. Interestingly, ICR, in turn, promotes p65 accumulation and activity, forming a positive feedback loop to amplify NF-κB signaling. Preventing the degradation of p65 using proteasome inhibitors rescued the expression of NF-κB targets suppressed by ICR. Yes After intravenous injection of adenovirus carrying shRNA for mouse ICR, the atherosclerotic plaque area was markedly reduced with the declined expression of ICR and ICAM1. 35714558 ICMT-DT LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Interaction[repressing p21 mediated by EZH2] ChIP//Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay In this research, we found that LINC00337 was up-regulated in the gastric cancer cells and tissue specimens.The mechanical experiments showed that LINC00337 epigenetically repressed the p21 via EZH2-mediated inhibition. Overall, this finding suggests that LINC00337 acts as the oncogene to promote gastric cancer cells proliferation through epigenetically repressing p21 mediated by EZH2, providing a new insight for gastric cancer. Yes The functional experiments illustrated that LINC00337 silencing repressed the proliferation, invasion and tumor growth in vitro and in vivo. 31217892 ICMT-DT LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[suppresses the expression of CNN1] qRT-PCR//MTT//Transwell Assay It was found that CNN1 downregulation and LINC00337 overexpression occurred in CRC tissues and cells. Taken together, this study indicates that LINC00337 facilitates the tumorigenesis and angiogenesis in CRC via recruiting DNMT1 to inhibit the expression of CNN1. Yes CNN1 overexpression or LINC00337 knockdown restricted CRC cell proliferation, migration/invasion, and proangiogenetic potency in vitro, which was substantiated by the in vivo experiments evidenced by facilitated tumor growth and MVD as well as elevated Ki67 and VEGF. 33328585 ICMT-DT LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues interaction[binds to E2F1] RNA Pull-Down//Western Blot//qRT-PCR//FISH//RIP Here we identified Linc00337 is an oncogenic lncRNA during PDAC progression. We found that the expression of Linc00337 is elevated in PDAC tissues and the higher Linc00337 predicts dismal prognosis. Mechanistically, Linc00337 binds to E2F1 and functions as an E2F1 coactivator to trigger the targets expression during PDAC progression. Here we identified Linc00337 is an oncogenic lncRNA during PDAC progression. We found that the expression of Linc00337 is elevated in PDAC tissues and the higher Linc00337 predicts dismal prognosis. Yes Functionally, Linc00337 promotes PDAC cell proliferation and cell cycle transition both in vitro and in vivo. 33054826 ICMT-DT LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues Interaction(miR-1285-3p/YTHDF1 ) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay LINC00337 expression was remarkably upregulated in lung adenocarcinoma.With respect to the mechanism, LINC00337 knockdown boosted miR-1285-3p expression and then restrained YTHDF1 expression post-transcriptionally. Crucially, both miR-1285-3p decrement and YTHDF1 overexpression successfully reversed the influence on cell proliferation, migration, invasion, and apoptosis caused by LINC00337 shRNA. Yes In addition, LINC00337 knockdown was shown to repress cell migration, invasion, and proliferation, as well as the cell cycle, and gear up apoptosis in lung adenocarcinoma in vitro and in vivo. 34663343 ICMT-DT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue and cell lines Interaction[inhibiting TIMP2 by recruiting DNMT1] Western Blot//Transfection//CCK8//qRT-PCR//RIP//Invasion Assay//ChIP In the NSCLC tissue and cell lines, LINC00337 was found to be remarkedly up-regulated.Mechanically, LINC00337 could recruit the epigenetic repressor DNMT1 to the promoter region of TIMP2 to silence its expression. In the NSCLC tissue and cell lines, LINC00337 was found to be remarkedly up-regulated, and the ectopic LINC00337 overexpression indicated the poor survival of NSCLC patients. Yes In vitro, gain and loss of functional assays showed that LINC00337 promoted the progression of NSCLC cells, including proliferation and invasion. In vivo, LINC00337 knockdown inhibited the tumor growth of NSCLC cells. 31632575 IATPR LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC cells and tissue Regulation[downregulating Mcl-1] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay Linc-ITGB1 expression level in ccRCC samples was markedly higher than that of the adjacent ones. Our findings suggested that linc-ITGB1 could enhance ccRCC cell migration and invasion via downregulating Mcl-1. The expression of linc-ITGB1 was closely related to the disease-free survival time of ccRCC patients. Yes Moreover, the migration and invasion of ccRCC cells were remarkably enhanced after linc-ITGB1 upregulation in vitro. 30915742 HYOU1-AS LncRNA Homo sapiens Breast Neoplasms TNBC tissues and cells Interaction(HYOU1) In Vivo Experiment//RNA Pull-Down//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//H&E Staining We identified an antisense lncRNA, HYOU1-AS, which is transcribed from the opposite strand of the hypoxia up-regulated 1 (HYOU1) gene, enriched in the nucleus and highly expressed in TNBC. In mechanistic studies, we found that HYOU1-AS could promote the expression of HYOU1, a proliferative gene, through competitively binding to hnRNPA1, an RNA-binding protein, to relieve its post-transcriptional inhibition of the HYOU1 mRNA. Yes HYOU1-AS knockdown could inhibit the proliferation and migration of the TNBC MDA-MB-231 cells, and reduce their xenograft tumor formation in nude mice. 33422616 HUWE1 CircRNA Homo sapiens Neuronal Injury SK-N-SH Cells Interaction( miR-433-3p/FGF7 axis) Western Blot//Transfection//Flow Cytometry//PCR//ELISA//IF In conclusion, circ-HUWE1 knockdown alleviates Amyloid-β-induced neuronal injury in SK-N-SH cells via miR-433-3p release-mediated FGF7 depletion. Yes We discovered that circ-HUWE1 absence alleviated Amyloid-β-induced cell viability degradation, cell apoptosis, and inflammatory responses in SK-N-SH cells. 35670955 HULC LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Regulation[miR-9-5p/MYH9 axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down Our results revealed that HULC was upregulated and miR-9-5p was downregulated in GC, and both were associated with clinicopathologic features of GC patients.A positive correlation was found between HULC expression and epithelial-to-mesenchymal transition (EMT) of GC tissues. Moreover, HULC repressed miR-9-5p expression by binding to miR-9-5p. The regulatory effects of HULC knockdown on GC cell proliferation, migration, invasion, EMT and apoptosis were reversed by introduction of anti-miR-9-5p. HULC regulated MYH9 expression by acting as a molecular sponge of miR-9-5p in GC cells. HULC knockdown inhibited tumor growth in vivo. Yes The regulatory effects of HULC knockdown on GC cell proliferation, migration, invasion, EMT and apoptosis were reversed by introduction of anti-miR-9-5p. 31726371 Irag2-208 LncRNA Rattus norvegicus Spinal Cord Injuries SCI model rat and lipopolysaccharide (LPS)-stimulated PC12 cells Interaction(miR-329-3p/IGF1R Axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA//EdU Staining TCTN2 expression was down-regulated in SCI model rat and lipopolysaccharide (LPS)-stimulated PC12 cells.TCTN2 targeted miR-329-3p and subsequently regulated the expression of its target IGF1R. Rescue assays suggested that miR-329-3p/IGF1R axis mediated the beneficial effects of TCTN2 exosomes on LPS-treated PC12 cells. Yes Tail vein injection of TCTN2 exosomes into rats significantly improved functional recovery of SCI. Meanwhile, TCTN2 exosomes treatment alleviated LPS-induced neuronal apoptosis, inflammation, and oxidative stress in vitro. 34623606 IRAIN LncRNA Homo sapiens Carcinoma, Renal Cell RC tissues and cells regulation[VEGFA ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry LncRNA IRAIN was poorly expressed in RC tissues and cells with a primary localization in the nucleus, while VEGFA was highly expressed. LncRNA IRAIN was also able to suppress RC tumor growth via repression of VEGFA in an in vivo mouse xenograft model. Yes Overexpression of lncRNA IRAIN or knockdown of VEGFA inhibited cell proliferation and migration and induced the apoptosis of RC cells. 32983957 IRAIN LncRNA Homo sapiens Multiple Myeloma blood,cell lines Interaction[miR-125b ] CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay The expression level of IRAIN in patients with MM was significantly lower compared to that in healthy individuals (Fig. 1A).Consistent with these data, the RPMI-8226 cell line expressed the highest level of miR-125b (Fig. 1F) and the lowest level of IRAIN (Fig. 1G).Furthermore, by using dual-luciferase reporter assays, IRAIN was identified as a target of miR-125b. Yes Knockdown of IRAIN promoted MM cell proliferation in vitro. 31788123 KCNQ1OT1 LncRNA Homo sapiens Ischemic Stroke blood Interaction[miR‐200a/FOXO3/ATG7 pathway] Western Blot//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//ChIP In this study, we revealed that potassium voltage‐gated channel subfamily Q member 1 opposite strand 1 (KCNQ1OT1) was significantly upregulated in ischemic stroke. Mechanistically, KCNQ1OT1 acted as a competing endogenous RNA of miR‐200a to regulate downstream forkhead box O3 (FOXO3) expression, which is a transcriptional regulator of ATG7. Knockdown of KCNQ1OT1 might inhibit I/R‐induced autophagy and increase cell viability via the miR‐200a/FOXO3/ATG7 pathway. This finding offers a potential novel strategy for ischemic stroke therapy. Yes Knockdown of KCNQ1OT1 remarkably reduced the infarct volume and neurological impairments in transient middle cerebral artery occlusion (tMCAO) mice. 30945454 KCNQ1OT1 LncRNA Homo sapiens maxillary sinus squamous cell carcinoma MSSCC tissues and MSSCC cell line (IMC-3) Regulation[miR-204/EphA7 axis] qPCR//Luciferase Report Assay Herein, we found that KCNQ1OT1 expression was markedly upregulated in MSSCC tissues and MSSCC cell line (IMC-3) by using quantitative reverse transcription-polymerase chain reaction. Moreover, we confirmed KCNQ1OT1 could directly interact with miR-204 by bioinformatic prediction and dual luciferase assay, and miR-204 inhibitor markedly reversed MSSCC tumor phenotypes induced by shKCNQ1OT1. Finally, we demonstrated that KCNQ1OT1/miR-204 facilitated MSSCC progression by regulating Eph receptor A7 (EphA7). Yes Loss-of-function experiments revealed that the deletion of KCNQ1OT1 inhibited cell proliferation, migration, and invasion. 31709597 KCNQ1OT1 LncRNA Homo sapiens Fracture Healing bone tissues Interaction[Wnt/β-catenin pathway] CCK8//qRT-PCR//Western Blot "Gene expression profiling and qRT-PCR revealed that lncRNA KCNQ1OT1 was significantly down-regulated in bone tissues of patients with delayed fracture healing.In HC-a cells, overexpression of lncRNA KCNQ1OT1 activated the Wnt/β-catenin signaling pathway, which could be suppressed by knocking down lncRNA KCNQ1OT1. Cell Counting Kit-8 (CCK-8) assay and 5(6)-carboxyfluorescein diacetate, succinimidyl ester (CFSE) results manifested that lncRNA KCNQ1OT1 remarkably promoted the proliferation and inhibited apoptosis of HC-a cells by activating the Wnt/β-catenin signaling pathway. " Yes Compared with the control group, knocking down lncRNA KCNQ1OT1 remarkably reduced the serum levels of alkaline phosphatase (ALP) and osteoprotegerin (OPG) in rabbits, and markedly decreased bone trabecular growth index (p<0.05). 31210283 KCNQ1OT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation[ miRNA-27b-3p/HSP90AA1 axis] qRT-PCR We demonstrated that the KCNQ1OT1 level was upregulated in NSCLC tissues and cell lines.These data revealed a role for KCNQ1OT1 as an oncogene through miR-27b-3p/HSP90AA1 axis during NSCLC progression. High KCNQ1OT1 level correlated with poor overall and progression-free survival in NSCLC patients. Yes KCNQ1OT1 facilitated proliferation, migration, and invasion in H460 cells. Furthermore, knockdown of KCNQ1OT1 reduced the expression of HSP90AA1. 30471108 KCNQ1OT1 LncRNA Homo sapiens Osteoporosis ADSCs-Exos Interaction(miR-141-5p) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay TNF-α dose-dependently increased miR-141-5p expression, inhibited viability, and promoted apoptosis of osteoblasts. However, miR-141-5p silencing or cocultured with ADSCs-Exos attenuated these effects. In addition, KCNQ1OT1-Exos could more significantly attenuate the induced cytotoxicity and apoptosis compared to ADSCs-Exos. Moreover, miR-141-5p was confirmed as the target of KCNQ1OT1 by luciferase reporter assay. Yes TNF-α dose-dependently increased miR-141-5p expression, inhibited viability, and promoted apoptosis of osteoblasts. However, miR-141-5p silencing or cocultured with ADSCs-Exos attenuated these effects. 34712334 KCNQ1OT1 LncRNA Homo sapiens Osteoporosis osteoporotic patients Interaction(miR-205-5p/RICTOR axis) qRT-PCR//Transfection//Luciferase Report Assay//Western Blot QPCR results indicated that KCNQ1OT1 and RICTOR were down-regulated, while miR-205-5p was up-regulated in the osteoporotic patients, as compared with non-osteoporotic controls. During the osteogenic differentiation of BMSCs, the expression of KCNQ1OT1 and RICTOR was upregulated, whereas miR-205-5p was downregulated. The interaction among KCNQ1OT1, miR-205-5p and RICTOR was validated by dual luciferase reporter system. KCNQ1OT1 promoted RICTOR expression via inhibiting miR-205-5p, therefore promoting osteogenesis as demonstrated by ALP assay, alizarin red staining and the increased expression of osteogenic markers (OPN, RUNX2 and OCN). Furthermore, KCNQ1OT1 overexpression or miR-205-5p inhibition could promote ALP activity and mineralization of BMSCs, while overexpressed miR-205-5p could reverse the effects of overexpressed KCNQ1OT1, and knockdown of RICTOR could reverse the effects of miR-205-5p inhibition. Yes The interaction among KCNQ1OT1, miR-205-5p and RICTOR was validated by dual luciferase reporter system. KCNQ1OT1 promoted RICTOR expression via inhibiting miR-205-5p, therefore promoting osteogenesis as demonstrated by ALP assay, alizarin red staining and the increased expression of osteogenic markers (OPN, RUNX2 and OCN). Furthermore, KCNQ1OT1 overexpression or miR-205-5p inhibition could promote ALP activity and mineralization of BMSCs, while overexpressed miR-205-5p could reverse the effects of overexpressed KCNQ1OT1, and knockdown of RICTOR could reverse the effects of miR-205-5p inhibition. 35341776 KCNQ1OT1 LncRNA Homo sapiens Leukemia, Promyelocytic, Acute clinical samples Interaction(FUS/MAP3K1) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis//ChIP The Cancer Genome Atlas database and our clinical samples, we found that KCNQ1OT1 was selectively highly expressed in APL. Further evidence showed that KCNQ1OT1 was mainly located in the cytoplasm of APL patient-derived NB4 cells and APL patient bone marrow samples. Mechanistically, KCNQ1OT1 bound to RNA binding protein FUS, and silencing either KCNQ1OT1 or FUS reduced the expression level and stability of MAP3K1 mRNA. Our results not only revealed that c-Myc transactivated KCNQ1OT1 and upregulated KCNQ1OT1 promoted APL cell proliferation, but also demonstrated that KCNQ1OT1 bound to FUS to synergistically stabilize MAP3K1 mRNA, thus facilitating APL cell proliferation. Yes Functional assays demonstrated that knockdown of KCNQ1OT1 reduced APL cell proliferation and increased apoptosis. 34404765 Kcnq1ot1 LncRNA Mus musculus Atherosclerosis atherosclerotic plaques of AS mice and THP-1 cells Interaction( miR-145-5p) RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//ELISA KCNQ1OT1 expression was upregulated and miR-145-5p was downregulated in atherosclerotic plaques of AS mice and ox-LDL-treated THP-1 cells. Additionally, KCNQ1OT1 acted as a molecular sponge of miR-145-5p and downregulated miR-145-5p expression. Furthermore, silencing miR-145-5p abolished the effect of KCNQ1OT1 knockdown. Yes Lipid metabolic disorders and inflammation in vivo and in vitro were attenuated by either KCNQ1OT1 knockdown or miR-145-5p overexpression. 34464666 Kcnq1ot1 LncRNA Mus musculus Acute Kidney Injury AKI model Interaction(miR-204-5p/NLRP3 ) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//H&E Staining//ELISA The results showed that Kcnq1ot1 was highly expressed in the AKI model in vivo and in vitro. Furthermore, Kcnq1ot1 inhibited miR-204-5p expression by competitively binding to miR-204-5p in HK-2 cells. miR-204-5p targeted NLRP3 and NLRP3 overexpression averted the inhibiting effect of miR-204-5p on apoptosis and inflammation in HK-2 cells in vitro. Yes Kcnq1ot1 knockdown promoted cell proliferation and prevented apoptosis and inflammation. Kcnq1ot1 knockdown in vivo promoted miR-204-5p expression, inhibited NLRP3 inflammasome activation, reduced levels of SCr, BUN, and KIM-1, and thus alleviated AKI and reduced apoptosis. 34858199 Kcnq1ot1 LncRNA Mus musculus Hepatic Ischemia/Reperfusion Injury hepatic tissue of HIRI mouse Interaction(miR-142a-3p/HMGB1 axis) qRT-PCR Our data revealed that KCNQ1OT1 expression was ascending in hepatic tissue of HIRI mouse.Mechanistically, KCNQ1OT1 functioned as a competing endogenous RNA which sponged miR-142a-3p, therefore promoted HMGB1 expression to activate TLR4/NF-κB signaling pathway in HIRI. Yes Moreover, deprivation of KCNQ1OT1 mitigated I/R-induced hepatic injury and pyroptosis in vivo. Further experiments demonstrated that silencing KCNQ1OT1 promoted proliferation and inhibited pyroptosis in hypoxia/reoxygenation (H/R)-induced primary mouse hepatocytes. 36308669 KCNQ1DN LncRNA Homo sapiens Carcinoma, Renal Cell renal cell carcinoma tissues Interaction[downregulating c-Myc] qRT-PCR//MTT//Tunel In the present study, we found that lncRNA KCNQ1DN was notably decreased in RCC tissues and cell lines. Mechanistically, KCNQ1DN inhibited the expression of c-Myc, which might further upregulate cyclin D1 and suppress p27 at mRNA and protein levels in RCC cells. Reporter gene assays revealed that the transcriptional activity of c-Myc promoter was inhibited by KCNQ1DN. The in vivo experiments in nude mice showed that KCNQ1DN overexpression dramatically repressed the growth of xenograft tumors and the expression of corresponding c-Myc. Yes Functional studies clarified that KCNQ1DN repressed the RCC cell growth and cell cycle progression. The in vivo experiments in nude mice showed that KCNQ1DN overexpression dramatically repressed the growth of xenograft tumors and the expression of corresponding c-Myc. 31528231 KCNMB2-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines Interaction(miR-374a-3p/ S100A10) qRT-PCR//Colony Formation Assay We found that lncRNA KCNMB2-AS1 was significantly upregulated both in BC tissues and cell lines, the expression level was highly correlated with pathological TNM stage. Mechanistically, lncRNA KCNMB2-AS1 could function as a competitive endogenous RNA (ceRNA) through direct sponging miR-374a-3p, which regulated the expression of S100A10. We found that lncRNA KCNMB2-AS1 was significantly upregulated both in BC tissues and cell lines, the expression level was highly correlated with pathological TNM stage. Yes Functionally, knockdown of lncRNA KCNMB2-AS1 dramatically inhibited the proliferation, migration, and invasion and of BC cells in vitro, and suppressed tumor growth in vivo. 34367236 KCNMB2-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction(miR-3194-3p/SAMD5 signal pathway) Flow Cytometry//qRT-PCR Here, we revealed the increased level of KCNMB2-AS1 in bladder cancer for the first time.Next, we revealed that KCNMB2-AS1 could interact with miR-3194-3p and uncovered that SAMD5 was a downstream target of miR-3194-3p. Yes Knockdown of KCNMB2-AS1 in vitro prevented the ability of proliferation, metastasis, and stemness of cancer cells. In vivo, the silencing of KCNMB2-AS1 also prevented tumor growth in vivo. 34026626 KCNMB2-AS1 LncRNA Homo sapiens Esophageal Neoplasms ESCA tissues Interaction(miR-3194-3p/PYGL axis) qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Transwell Assay We discovered that KCNMB2-AS1 was significantly upregulated in ESCA. KCNMB2-AS1 bound with miR-3194-3p, and glycogen phosphorylase L (PYGL) was a direct target of miR-3194-3p. KCNMB2-AS1 upregulated PYGL expression by directly binding with miR-3194-3p. Yes KCNMB2-AS1 downregulation suppressed the growth, invasion, migration and stemness of ESCA cells. 34516362 KCNK15-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction[ KCNK15-AS1-DNMT1-MAPK and KCNK15-AS1-HDAC1-AKT] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP The expression of KCNK15-AS1 was lower in the tumor tissue compared to the normal tissue.In this study, we identified two regulatory axes, namely KCNK15-AS1-DNMT1-MAPK and KCNK15-AS1-HDAC1-AKT, which were associated with gastric cancer progression. Chidamide and 5-azacytidine might provide new modes for treating gastric cancer. Yes Both the overexpression of KCNK15-AS1 and the knockdown of the expression of miR-21 inhibited proliferation and promoted apoptosis and decreased the level of MMP-9, bcl-2, and MMP-2 but increased the level of Bax. 31572012 KCNK15-AS1 LncRNA Homo sapiens Osteoarthritis ATDC5 cells Interaction( RP11-445H22.4-miR-301a-CXCR4 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//ELISA In addition, miR-301a directly bound to RP11-445H22.4, and suppression of miR-301a inversed the effects of RP11-445H22.4 inhibition. Furthermore, CXCR4 was a direct target of miR-301a, and CXCR4 silencing increased cell viability, decreased apoptosis and inflammatory cytokines secretions in LPS-treated ATDC5 cells. Besides, we found that CXCR4 silencing blocked LPS-activated NF-κB and MAPK/ERK pathways. Yes However, RP11-445H22.4 inhibition significantly rescued LPS-induced injuries by promoting cell viability, suppressing apoptosis and inflammatory cytokines secretions in ATDC5 cells. 29414810 KCNA3 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[YAP1 ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Invasion Assay We found that lncRNA kcna3 was lowly expressed in CRC tissues, and its low expression was closely associated with patients' higher TNM grade and the higher occurrence rate of lymphatic metastasis and distant metastasis, as well as shorter OS. In conclusion, this study revealed that lncRNA kcna3 exerts a tumor-inhibit role in CRC progression through down-regulating YAP1 expression, indicating that lncRNA kcna3/YAP1 might be served as a new prognostic biomarker and therapeutic target for CRC. We found that lncRNA kcna3 was lowly expressed in CRC tissues, and its low expression was closely associated with patients' higher TNM grade and the higher occurrence rate of lymphatic metastasis and distant metastasis, as well as shorter OS. Yes Enhanced expression of lncRNA kcna3 inhibited SW620 cells' proliferation, migration and invasion, and induced cell apoptosis in vitro, and repressed CRC tumor growth in vivo. 30099342 KB-1732A1.1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[miR-200 s ] RNA Pull-Down//Northern Blot//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray//BrdU//Colony Formation Assay Further, LincK was frequently elevated in breast cancer compared with normal breast tissue in clinical samples.Mechanistically, LincK may share common miRNA response elements with PBK and ZEB1 and regulate the effects of miR-200 s. Yes Moreover, knockdown of LincK repressed tumorigenesis, and ectopic expression of LincK promoted tumor growth in MCF-7 xenograft model. 30795783 KB-1507C5.2 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 KCNQ1OT1 LncRNA Homo sapiens Small Cell Lung Carcinoma SCLC tissues Expression [highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Microarray//Colony Formation Assay//Transwell Assay The results showed that KCNQ1OT1 expression was upregulated in SCLC tissues and was a poor prognostic factor for patients with SCLC. Mechanistic investigation showed that KCNQ1OT1 can activate transforming growth factor-β1 mediated epithelial-to-mesenchymal transition in SCLC cells. Yes Knockdown of KCNQ1OT1 inhibited cell proliferation, migration, chemoresistance and promoted apoptosis of SCLC cells. 33705625 KCNQ1OT1 LncRNA Homo sapiens Myocardial Infarction MI patients, I/R mouse and H/R-induced cell model Interaction(miR-26a-5p/ATG12 pathway.) In Vivo Experiment//Western Blot//Transfection//Tunel//qRT-PCR//Luciferase Report Assay KCNQ1OT1 was up-regulated while miR-26a-5p was decreased in MI patients, I/R mouse and H/R-induced cell model. Either KCNQ1OT1 knockdown or miR-26a-5p mimics caused inhibition of autophagy related 12 homolog (ATG12), which was the direct target of miR-26a-5p. In vivo, KCNQ1OT1 promoted cardiomyocytes apoptosis via miR-26a-5p/ATG12 pathway. Yes KCNQ1OT1 knockdown inhibited cell autophagy and protected cardiomyocytes from apoptosis by up-regulating miR-26a-5p. 34089766 IRAIN LncRNA Homo sapiens Glioma glioma tissues Regulation(IGF-1R-PI3K-NF-κB signaling pathway) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay IRAIN was down-regulated in glioma tissues (compared with adjacent normal tissues), and the low IRAIN expression was significantly linked with the larger tumor volume and higher pathological stages. The WB result showed that overexpressing IRAIN inactivated the IGF-1R-PI3K-NF-κB pathway. Additionally, the IGF-1R knockdown model was established in U251 cells. Si-IGF-1R induced cell proliferation inhibition, promoted cell death, and reduced cell migration and TMZ resistance, whereas Si-IGF-1R+IRAIN group showed no additional effects on glioma cells compared with the Si-IGF-1R group. Yes Functionally, overexpressing IRAIN abated glioma cell proliferation, invasion, and migration, promoted apoptosis, and attenuated IGF-1R-PI3K-NF-κB expression and temozolomide (TMZ) resistance, which was also confirmed in the xenograft tumor experiment. 35102541 KCNQ1OT1 LncRNA Homo sapiens Melanoma CD8+ T cells Interaction(miR-34a/STAT3/PD-L1 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay KCNQ1OT1 regulated the progression of the melanoma via its action as a miR-34a sponge. STAT3 was found to be a downstream target of miR-34a, resulting in transcriptional regulation of Programmed cell death 1 ligand 1 (PD-L1). KCNQ1OT1 regulated STAT3 by targeting miR-34a. Knockdown of KCNQ1OT1 reduced PD-L1 level, enhanced CD8+ T cell cytotoxicity, and proliferation and inhibited apoptosis of CD8+ T cells. KCNQ1OT1 was upregulated in melanoma tissues leading to a poor prognosis, and knocking down it inhibited melanoma cell proliferation, migration, and invasion. Yes KCNQ1OT1 was upregulated in melanoma tissues leading to a poor prognosis, and knocking down it inhibited melanoma cell proliferation, migration, and invasion. 36399467 KCNQ1OT1 LncRNA Homo sapiens Ovarian Neoplasms Interaction[Wnt/β-catenin] Western Blot//Wound Healing Assay//CCK8//Flow Cytometry//Transwell Assay The proliferation rate of cells was overtly decreased in KCNQ1OT1 knockdown group but significantly increased in KCNQ1OT1 overexpression group. The results of both wound healing and transwell assays showed that the migration ability of cells was reduced in KCNQ1OT1 knockdown group but raised in KCNQ1OT1 overexpression group. According to flow cytometry, the cell cycle was clearly arrested in the G0/G1 phase in KCNQ1OT1 knockdown group. The results of Western blotting and fluorescence immunoassay revealed that compared with that in control group, the expression level of β-catenin protein evidently declined in KCNQ1OT1 knockdown group, but it was notably elevated in KCNQ1OT1 overexpression group. Yes "Results showed that compared with that in con_x0002_trol group, the proliferation rate of cells was sig_x0002_nificantly decreased in KCNQ1OT1 knockdown group but remarkably elevated in KCNQ1OT1 overexpression group, showing statistically sig_x0002_nificant differences (p<0.05) (Figure 1)." 31696465 KCNQ1OT1 LncRNA Homo sapiens Ovarian Neoplasms OC cells regulation[MIR-142-5p/CAPN10 axis] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We showed KCNQ1OT1 was elevated expression in OC cells and indicated poorer overall survival of OC patients. At length, we showed KCNQ1OT1 could regulate OC development via MIR-142-5p/CAPN10 axis. We showed KCNQ1OT1 was elevated expression in OC cells and indicated poorer overall survival of OC patients. Yes Besides, we found KCNQ1OT1 could promote OC cell proliferation and migration in vitro. 31909901 KCNQ1OT1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Regulation(EIF2B5) qRT-PCR//RIP//ChIP Expression of lncRNA KCNQ1OT1 was increased in OC tissues and cells. EIF2B5 expression was downregulated in OC, which was inversely correlated with KCNQ1OT1. Knockdown of KCNQ1OT1 inhibited OC cell proliferation and metastasis. KCNQ1OT1 could downregulate EIF2B5 expression by recruiting DNA methyltransferases into EIF2B5 promoter. Furthermore, interference of EIF2B5 expression rescued KCNQ1OT1 depletion-induced inhibitory impact on OC cell proliferation and metastasis. Yes Knockdown of KCNQ1OT1 inhibited OC cell proliferation and metastasis. 36100884 KCNQ1OT1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-125b-5p/CD147 axis) CCK8//qRT-PCR KCNQ1OT1 was high expression and miR-125b-5p was low expression in OC, and KCNQ1OT1 was negatively correlated with that of miR-125b-5p in OC specimens. KCNQ1OT1 was positively correlated with that of CD147 in OC specimens, and KCNQ1OT1 accelerated OC progression via miR-125b-5p/CD147 axis. Yes KCNQ1OT1 promoted OC cell proliferation and metastasis by binding to miR-125b-5p. miR-125b-5p targeted CD147, and which was negatively correlated with that of miR-125b-5p in OC specimens. 36191448 KCNQ1OT1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissue and cell lines Regulation[miR-145-5p/PCBP2 axis] Western Blot//Wound Healing Assay//Tunel//CCK8//qRT-PCR//Flow Cytometry//IF//Colony Formation Assay//Transwell Assay KCNQ1OT1 was significantly overexpressed in BC tissue and cell lines.KCNQ1OT1 serves as competing endogenous RNA (ceRNA) to up-regulate PCBP2 via sponging miR-145-5p in BC progression. Yes KCNQ1OT1 depletion repressed cell proliferation, migration and invasion, whereas encouraged cell apoptosis. 31827399 KCNQ1OT1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues regulation[MiR-218-5p/HS3ST3B1] qRT-PCR In this study, we demonstrated that KCNQ1OT1 expression in bladder cancer tissues was notably up-regulated compared with in normal adjacent tissues, and KCNQ1OT1 modulated the malignant phenotypes of bladder cancer cells. In conclusion, KCNQ1OT1 can promote the progression of bladder cancer through regulation of miR-218-5p/HS3ST3B1, which is expected to serve as a new therapeutic target for bladder cancer. Yes Overexpressed miR-218-5p would inhibit the proliferation and metastasis of bladder cancer cells while facilitating apoptosis. 32820233 KCNQ1OT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Regulation[miR-185-5p/Rab14 axis] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay KCNQ1OT1 was upregulated in OSCC tissues and cells.KCNQ1OT1 silencing suppressed OSCC cell malignancy and downregulated miR-185-5p level, which showed upregulated expression in OSCC samples. Rab14 as a target gene of miR-185-5p was highly expressed in OSCC. KCNQ1OT1 knockdown impaired the invasion capability of OSCC cells, promoted apoptosis, and suppressed Rab14 expression. The inhibition of miR-185-5p in KCNQ1OT1 silencing cells reversed the suppression of Rab14 and restored the cancerous growth of OSCC cells. These results indicated that KCNQ1OT1 promoted OSCC tumorigenesis via the modulation of miR-185-5p/Rab14 axis, which may serve as a therapeutic target for the treatment of OSCC. Yes KCNQ1OT1 silencing suppressed OSCC cell malignancy and downregulated miR-185-5p level, which showed upregulated expression in OSCC samples.KCNQ1OT1 knockdown impaired the invasion capability of OSCC cells, promoted apoptosis, and suppressed Rab14 expression. 31755091 KCNQ1OT1 LncRNA Homo sapiens Osteosarcoma OS tissues Interaction[ sponging miR-4458 and upregulating CCND2] CCK8//qRT-PCR Our work demonstrated the upregulation of KCNQ1OT1 in osteosarcoma through qRT-PCR. Collectively, the results of rescue experiments suggested that the oncogenic role of KCNQ1OT1 was performed through sponging miR-4458 and upregulating CCND2 during osteosarcoma development, providing a novel perspective of intervention in osteosarcoma management. Yes loss of function assay (CCK-8, transwell migration) indicated KCNQ1OT1 promoted cell proliferation, migration in osteosarcoma. 31392505 KCNQ1OT1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines regulation[Wnt/β-catenin signaling,miR‑3666/KLF7 axis] qRT-PCR In the present study, a high KCNQ1OT1 expression was detected in human OS tissues and cell lines. Collectively, the present study demonstrates that KCNQ1OT1 facilitates OS progression and activates Wnt/β‑catenin signaling by targeting the miR‑3666/KLF7 axis. Yes Loss?of?function assays demonstrated that KCNQ1OT1 silencing suppressed cell proliferative, migratory and invasive abilities in OS. 33416089 KCNQ1OT1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells interaction[ miR-129-5p] qRT-PCR//MTT//Transwell Assay The result revealed that KCNQ1OT1 was highly expressed in osteosarcoma tissues and cells.The luciferase reporter assay and pull-down assay demonstrated that KCNQ1OT1 directly interact with miR-129-5p. Yes KCNQ1OT1-siRNA inhibited the proliferation, invasion, and drug resistance of osteosarcoma cells. 32953888 KCNQ1OT1 LncRNA Homo sapiens Osteosarcoma cell lines regulation[KCNQ1OT1/miR-34c-5p/ALDOA axis ] RNA Pull-Down//Western Blot//Tunel//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Cell Cycle Assay//IHC Here, we report that lncRNA KCNQ1OT1 was upregulated in OS.Targeting the KCNQ1OT1/miR-34c-5p/ALDOA axis may be a potential therapeutic target in OS treatment. Yes Meanwhile, functional experiments demonstrated that the KCNQ1OT1 facilitated proliferation and suppressed apoptosis of OS cells. 32332718 KCNQ1OT1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells regulation[miR-491-5p/PKM2 axis] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay In this study, KCNQ1OT1 was significantly up-regulated in CC patient cancerous tissues and cell lines, and its high expression was significantly related to tumor volume increase and poor differentiation. In conclusion, KCNQ1OT1 enhances CC cell progression through the miR-491-5p/PKM2 axis. In this study, KCNQ1OT1 was significantly up-regulated in CC patient cancerous tissues and cell lines, and its high expression was significantly related to tumor volume increase and poor differentiation. Yes KCNQ1OT1 overexpression significantly promoted CC cell proliferation, metastasis and radioresistance. On the contrary, KCNQ1OT1 knockdown compared to the control group inhibited the above biological behavior of CC cells. 33146005 KCNQ1OT1 LncRNA Homo sapiens Uterine Cervical Neoplasms clinical tumor tissue specimens and CC cell lines Interaction(miR-296-5p/HYOU1 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//Invasion Assay//Transwell Assay Elevated KCNQ1OT1 and HYOU1 as well as reduced miR-296-5p were observed in clinical tumor tissue specimens and CC cell lines. Results revealed that upregulation of miR-296-5p counteracted the enhancing effects of overexpressed KCNQ1OT1 on the proliferative, migrative and invasive abilities of CC cells. Additionally, HYOU1 overexpression abolished the suppressing effects of silenced KCNQ1OT1 on the malignant behaviors of CC cells and tumor growth. Yes Results revealed that upregulation of miR-296-5p counteracted the enhancing effects of overexpressed KCNQ1OT1 on the proliferative, migrative and invasive abilities of CC cells. Additionally, HYOU1 overexpression abolished the suppressing effects of silenced KCNQ1OT1 on the malignant behaviors of CC cells and tumor growth. 34704918 KCNQ1OT1 LncRNA Homo sapiens Uterine Cervical Neoplasms HeLa cells Interaction(KCNQ1OT1/miR-1270/LOXL2 axis ) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay KCNQ1OT1 expression was the highest in HeLa cells but lowest in SiHa cells whose upregulation improved the viability but inhibited the apoptosis in SiHa cells while knockdown of KCNQ1OT1 caused opposite results in HeLa cells. MiR-1270 was sponged and negatively modulated by KCNQ1OT1. MiR-1270 mimics caused low viability and high apoptosis of SiHa cells but miR-1270 inhibitor reverse its roles in HeLa cells. LOXL2, the target of miR-1270, positively interplayed with KCNQ1OT1 but had negative interaction with miR-1270. LOXL2 overexpression promoted viability and decreased apoptosis of SiHa cells but knockdown of LOXL2 restored its effects in HeLa cells. Moreover, LOXL2 and phosphorylated AKT (p-AKT) protein expressions were downregulated by suppressed KCNQ1OT1 and LOXL2 and miR-1270 mimics but promoted by overexpressed KCNQ1OT1 and LOXL2 and miR-1270 inhibitor. Additionally, LY294002 treatment caused low KCNQ1OT1 RNA expression and decreased LOXL2 and p-AKT protein expressions. Yes KCNQ1OT1 expression was the highest in HeLa cells but lowest in SiHa cells whose upregulation improved the viability but inhibited the apoptosis in SiHa cells while knockdown of KCNQ1OT1 caused opposite results in HeLa cells. 35218109 KCNQ1OT1 LncRNA Homo sapiens Cholangiocarcinoma tissues and cell lines Regulation[miR-140-5p/SOX4 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay As expected, KCNQ1OT1 was highly expressed in CCA tissues and cell lines.Mechanism investigation revealed that KCNQ1OT1 can act as a ceRNA to improve CCA progression by regulating miR-140-5p/SOX4 axis. Yes Whereas, the negative effect of KCNQ1OT1 on the cell apoptosis was tested with flow cytometry analysis. 30243712 KCNQ1OT1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(miR-211-5p/CHI3L1 Pathway) Western Blot//Migration Assay//RIP//Luciferase Report Assay//Transwell Assay KCNQ1OT1 expression was upregulated in PCa tissues and cells. KCNQ1OT1 bound miR-211-5p competitively, and miR-211-5p targeted CHI3L1 3'-UTR. miR-211-5p expression was downregulated, whereas CHI3L1 (YKL-40) expression was upregulated. miR-211-5p levels were negatively correlated with KCNQ1OT1 expression and CHI3L1 mRNA. The decrease in YKL-40 expression in PCa cells induced by the downregulation of KCNQ1OT1 expression could be offset by miR-211-5p inhibitor transfection. Yes Downregulating this expression inhibited PCa cell invasion, proliferation, and metastasis. 33688211 KCNQ1OT1 LncRNA Homo sapiens Prostatic Neoplasms PCa cells Interaction(miR-137-3p/PTP4A3 axis) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay These findings suggest that endosulfan can indeed promote cell migration and invasion via the KCNQ1OT1/miR-137-3p/PTP4A3 axis in PCa cells. Yes Functionally, silencing of KCNQ1OT1 repressed cell migration and invasion, and caused alterations of EMT biomarkers and critical proteins in the TGF-β signaling pathway, which were all restored by co-transfection with anti-miR-137-3p or PTP4A3-WT plasmid. 35817112 KCNQ1OT1 LncRNA Homo sapiens Retinoblastoma RB tissue regulation[miR-153-3p/HIF-1α axis] Western Blot//Flow Cytometry//qRT-PCR//CCK8//RIP//Transwell Assay The results of our study showed that KCNQ1OT1 expression was markedly enhanced in RB tissue samples, and KCNQ1OT1 knockdown had an inhibitory effect on the proliferation,In conclusion, our study indicates that KCNQ1OT1 can increase the malignancy of RB cells via regulating miR-153-3p/HIF-1α axis. Yes The results of our study showed that KCNQ1OT1 expression was markedly enhanced in RB tissue samples, and KCNQ1OT1 knockdown had an inhibitory effect on the proliferation,migration, invasion and viability of RB cells. 33051357 KCNQ1OT1 LncRNA Homo sapiens Retinoblastoma Fifty cases of Rbs and their adjacent normal tissues Interaction(miR-134/TRIM44 pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay lncRNA KCNQ1OT1 was up-regulated in Rb tissues and Rb cell lines. The analysis of the mechanism of KCNQ1OT1 showed that KCNQ1OT1 can sponge miR-134, and miR-134 may inhibit TRIM44 expression. In addition, the expression of KCNQ1OT1 was negatively correlated with the disease-free survival rate of RB patients. Yes Silencing KCNQ1OT1 could significantly inhibit the RB progression in vivo and in vitro. 33818859 KB-1460A1.5 LncRNA Homo sapiens Glioma clinical glioma tissues Interaction(miR-130a-3p/TSC1/mTOR/YY1 feedback loop) Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//IHC//Invasion Assay In this study, using online data sets combined with collected clinical glioma tissues, we determined that the lncRNA KB-1460A1.5 is downregulated and positively correlated with prognosis in glioma. Mechanistically, tandem mass tag (TMT)-based quantitative proteomic analysis revealed that KB-1460A1.5 preferentially affects the Akt/TSC1/mTOR pathway. KB-1460A1.5 was found to function as a competing endogenous RNA (ceRNA) to regulate the expression of TSC1, a key regulatory component of the mTOR pathway, by sponging miR-130a-3p in glioma cells. Furthermore, our data demonstrate that the mTOR pathway regulates the expression of the transcription factor Yin Yang 1 (YY1), which in turn binds directly to the KB-1460A1.5 promoter and affects the expression of KB-1460A1.5. In this study, using online data sets combined with collected clinical glioma tissues, we determined that the lncRNA KB-1460A1.5 is downregulated and positively correlated with prognosis in glioma. Yes Functional experiments showed that overexpression of KB-1460A1.5 inhibits glioma cell proliferation, migration and invasion in vitro and in vivo, while downregulation of KB-1460A1.5 has the opposite effects. 34728310 KAT7 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] Western Blot//CCK8//Colony Formation Assay//EdU Staining//Transwell Assay The expression of lncRNA-KAT7 in CRC tissues was lower than that in matched normal tissues and normal intestinal epithelial cells (P < 0.05). Western blot analysis showed that the expression of lncRNA-KAT7 was up-regulated in HCT116 cells, the expression of E-cadherin increased, and the expression of Vimentin, MMP-2 and β-catenin protein was down-regulated so did the phosphorylation NF-κB P65. The results confirm that the expression of lncRAN-KAT7 can inhibit the malignant phenotype of CRC cells. Decreased expression of lncRNA-KAT7 is associated with clinicopathological features of poor CRC patients. Yes In vitro experiments showed that up-regulation of lncRNA-KAT7 expression in CRC cells inhibited cell proliferation and migration. In vivo animal experiments showed that the lncRNA-KAT7 also inhibited tumor growth. 30858757 KASRT LncRNA Homo sapiens Osteosarcoma osteosarcoma cell lines Regulation(P21/CCND1 pathway) qRT-PCR//Western Blot Lnc-KASRT expression was increased in most osteosarcoma cell lines compared to control cell line. Lnc-KASRT serves as a potential treatment target via regulating SRSF1-related KLF6 alternative splicing and following P21/CCND1 pathway in osteosarcoma. Yes Lnc-KASRT overexpression promoted cell viability, mobility, and anti-apoptotic marker expression, while reducing apoptosis rate and pro-apoptotic marker expression; meanwhile, it regulated SRSF1, KLF6 alternative splicing (increased KLF6-splice variant 1 (KLF6-SV1), decreased KLF6-wild type (KLF6-WT)), and followed P21/CCND1 pathway in U-2OS/Saos-2 cells. The lnc-KASRT knockdown exhibited opposite trends. 34568030 JPX LncRNA Homo sapiens Stomach Neoplasms GC tissues, cells regulation[inhibiting miR-197] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The Cancer Genome Atlas database and the RT?qPCR results indicated that JPX expression was upregulated and miR?197 expression was downregulated in patients with GC and in GC cells.Collectively, the results indicated that lncRNA JPX promoted GC progression by regulating CXCR6 and autophagy via inhibiting miR‑197. Moreover, high JPX expression and low miR?197 expression in patients with GC indicated poor prognosis. Yes Compared with the short hairpin RNA (sh) negative control (NC) group, NCI?N87 and MKN?45 cells in the shJPX group displayed decreased cell viability and invasion, as well as a wider scratch width. NCI?N87 and MKN?45 cells in the shJPX + miR?197 inhibitor group had increased viability and invasion, but a narrower scratch width compared with the shJPX group. 33215222 ITGB1-DT LncRNA Homo sapiens Adenocarcinoma of Lung lung cancer cells Interaction(hsa-miR-30b-3p/ARNTL2 axis ) Transfection//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Our study identified the ITGB1-DT/ARNTL2 axis as a novel prognostic biomarker affects the prognosis of lung adenocarcinoma. Yes The CCK-8, transwell, and colonu formation assays suggested that ITGB1-DT/ARNTL2 promotes the progression of lung adenocarcinoma. And hsa-miR-30b-3p reversed the ITGB1/ARNTL2-mediated oncogenic processes. 34906142 ITGB1-DT LncRNA Homo sapiens lung non-small cell carcinoma NSCLC patients and cells Regulation( MAPK/ERK signaling) Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//Cell Proliferation Assay//Invasion Assay TGB1-DT was overexpressed in NSCLC. In conclusion, inhibition of ITGB1-DT expression delayed the growth and metastasis of NSCLC using the MAPK/ERK signaling mechanism and enhanced the sensitivity of NSCLC to cisplatin drugs. Elevated ITGB1-DT expression was related to the late T stage, N stage, M stage, short overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) of NSCLC patients. ITGB1-DT was the independent risk factors for poor prognosis, and had diagnostic value for NSCLC patients. Yes Interfering with the ITGB1-DT expression can inhibit the proliferation, migration, and invasion of A549, H1299, and drug-resistant A549/DDP, possibly due to the inhibition of p38 MAPK and ERK phosphorylation levels. 35968342 ITGB1-DT LncRNA Homo sapiens gastric adenocarcinoma STAD tissues and cells Expression(highly expressed) Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Invasion Assay ITGB1-DT was expressed up-regulated in STAD tissues. GSEA results showed that ITGB1-DT may be involved in STAD progression through the insulin, p53, mechanistic target of rapamycin kinase (MTOR), and other signaling pathways. Overexpression of ITGB1-DT was significantly correlated with the levels of STAD B cells, T cells, T helper cells, CD8 T cells, cytotoxic cells, and other immune cells. ITGB1-DT overexpression was associated with the T stage, therapeutic effect, overall survival, progression-free interval status, and poor prognosis in STAD patients. ITGB1-DT overexpression was valuable in diagnosing STAD and a negative factor affecting the prognosis of STAD patients. Yes Interference with ITGB1-DT expression inhibited STAD cell proliferation, invasion, and migration. 35557569 ITGB1 LncRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cell lines Interaction[microRNA-10a] CCK8//qRT-PCR//Colony Formation Assay LncRNA ITGB1 was found upregulated in BCa tissues and cell lines. The expression levels of ITGB1 and microRNA-10a in BCa tissues were negatively correlated. ITGB1 downregulation was found to be able to enhance microRNA-10a expression, suggesting that microRNA-10a may be a potential target for ITGB1 in BCa. In addition, cell reverse experiment also verified that ITGB1 could regulate the expression of microRNA-10a, and their interaction affected the malignant progression of BCa. Yes Knockdown of lncRNA ITGB1 remarkably inhibited cell proliferation. 31486485 itchyE3ubiquitinproteinligase CircRNA Homo sapiens Prostatic Neoplasms cell lines(DU 145, 22RV1, VCaP, and PC-3) Interaction[Targeting MiR-197] CCK8//qRT-PCR Circular RNA itchy E3 ubiquitin protein ligase expression was decreased in DU 145, 22RV1, VCaP, and PC-3 cells compared to RWPE cells. Cell apoptosis rate was elevated in circular RNA itchy E3 ubiquitin protein ligase overexpression plasmids group compared to control overexpression plasmids group at 48 hours, and Western blot showed the similar results. Micro RNA-197 but not micro RNA-31 or micro RNA-432 was the target micro-RNA of circular RNA itchy E3 ubiquitin protein ligase. In rescue experiments, cell proliferation rate was elevated, but apoptosis rate was reduced in circular RNA itchy E3 ubiquitin protein ligase overexpression plasmids/micro RNA (+) group compared to circular RNA itchy E3 ubiquitin protein ligase overexpression plasmids group, indicating that circular RNA itchy E3 ubiquitin protein ligase upregulation inhibited cell proliferation but promoted apoptosis through downregulating micro RNA-197. Yes In PC-3 cells, cell proliferation rate was reduced in circular RNA itchy E3 ubiquitin protein ligase overexpression plasmids group compared to control overexpression plasmids group at 48 hours and 72 hours. 31694481 ITCH CircRNA Homo sapiens Stomach Neoplasms gastric cancer cell lines and tissues regulation[Wnt/β-catenin pathway] qRT-PCR//RIP//PCR//IP//IF Through RTq-PCR assays, we observed that cir-ITCH expression was attenuated in gastric cancer cell lines and tissues, with cir-ITCH expression in gastric cancer tissues with lymph node metastasis being considerably lower than that observed in gastric cancer tissues without lymph node metastasis. In summary, cir-ITCH was shown to prevent gastric cancer tumourgenesis through the Wnt/β-catenin signalling pathway by sequestering miR-17. Through RTq-PCR assays, we observed that cir-ITCH expression was attenuated in gastric cancer cell lines and tissues, with cir-ITCH expression in gastric cancer tissues with lymph node metastasis being considerably lower than that observed in gastric cancer tissues without lymph node metastasis. Yes Moreover, in vivo and in vitro experimental results showed that cir-ITCH can act as a tumour suppressor to prevent gastric cancer tumourgenesis by sponging miR-17 33060778 ITCH CircRNA Homo sapiens Stomach Neoplasms GC cell lines, GC tissues and their serum-derived exosomes Interaction( miR-199a-5p/Klotho axis) Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay In the present study, we found that circ-ITCH was down-regulated in GC cell lines, GC tissues and their serum-derived exosomes.Bioinformatic analysis and luciferase reporter assay confirmed that circ-ITCH acted as miR-199a-5p sponge and increased the level of Klotho. Yes Functional assays showed that circ-ITCH overexpression inhibited the proliferation, migration, invasion and epithelial mesenchymal transition (EMT) of GC cells, whereas circ-ITCH knockdown appeared an opposite effect. 33499704 ITCH CircRNA Homo sapiens Carcinoma, Hepatocellular cell lines regulation[Wnt/β-catenin signaling pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay Compared with that in human normal liver L-02 cell line, the expression of circRNA-ITCH was significantly down-regulated in HCC Huh-7, U251, HB611 and SMMC-7721 cell lines (p<0.05).CircRNA-ITCH affects the proliferation and apoptosis of HCC cells through inhibiting the Wnt/β-catenin signal transduction pathway, thereby exerting a carcinogenic effect in the occurrence and development of HCC. Yes According to the results of CCK-8 assay, colony formation assay and flow cytometry, the overexpression of circRNA-ITCH could obviously inhibit cell proliferation, suppress colony formation ability and induce apoptosis (p<0.05). 32862578 ITCH CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues regulation[miR-106a/CDH1 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay Circ-ITCH was down-regulated in ovarian cancer and positively correlated with 5-year overall survival of patients with ovarian cancer. Circ-ITCH suppressed proliferation, invasion, glycolysis, and promoted apoptosis of ovarian cancer cells by modulating the miR-106a/CDH1 axis. Circ-ITCH was down-regulated in ovarian cancer and positively correlated with 5-year overall survival of patients with ovarian cancer. Yes Functionally, circ-ITCH overexpression hindered proliferation, invasion, glycolysis and promoted apoptosis of ovarian cancer cells. 32714095 ITCH CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines regulation[miR-421/PDCD4 Axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay ur results showed that circ-ITCH expression was remarkably decreased in OSCC tissues and cell lines. In conclusion, our study reveals that circ-ITCH serves as a tumor suppressor in OSCC partly by regulating miR-421/PDCD4 axis. Yes Moreover, functional assays demonstrated that circ-ITCH overexpression significantly inhibited OSCC cell proliferation and induced cell apoptosis. 32765068 ITCH CircRNA Homo sapiens Osteosarcoma cancer cell lines regulation[cir-ITCH/miR-7/EGFR Pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay In this study, we performed experiments with the human osteoblast cell line hFOB1.19 and several osteosarcoma cancer cell lines and the results showed that the expression of cir-ITCH in osteosarcoma cancer cell lines was significantly upregulated compared to that in the human osteoblast cell line.In conclusion, our research uncovered an important role of the cir-ITCH/miR-7/EGFR pathway in the migration and invasion of osteosarcoma cells and suggested that cir-ITCH may be a prognostic marker and a promising therapeutic target for osteosarcoma. Yes In addition, the results showed that cir-ITCH could promote the migration, invasion, and growth of osteosarcoma cells. 31960764 ITCH CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines regulation[microRNA-93-5p/FOXK2 Axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our results showed that circ-ITCH was lowly expressed in both human cervical cancer tissues and cell lines.Mechanism investigations proved that circ-ITCH executed its tumor suppressive activity through sponging microRNA-93-5p (miR-93-5p) and regulating the expression of forkhead box K2 (FOXK2). Yes Overexpression of circ-ITCH in HeLa cells significantly suppressed cell proliferation, migration, and invasion. A xenograft tumor model was established to evaluate the role of circ-ITCH in vivo. 31993998 ITCH CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues & cell lines Interaction(circ-ITCH/miR-214 axis) In Vivo Experiment//IHC//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay a negative correlation between circ-ITCH and miR-214 expression and a positive correlation between circ-ITCH and PTEN expression were observed in NPC tissues. Downregulation of circ-ITCH expression was also observed in NPC cell lines. In addition, upregulation of circ-ITCH markedly inhibited NPC cell proliferation, migration and invasion. Furthermore, circ-ITCH was confirmed to exert its function by sponging miR-214. PTEN was found to be a direct target gene of miR-214 and its expression was negatively correlated with miR-214 expression in NPC tissues. Moreover, our results showed that the circ-ITCH/miR-214 axis regulated NPC proliferation, migration and invasion through regulating the expression of PTEN. Upregulation of circ-ITCH or PTEN blocked miR-214-mediated promotion of NPC tumorigenesis in vitro. Additionally, upregulation of circ-ITCH also suppressed NPC tumorigenesis in vivo. Yes In addition, upregulation of circ-ITCH markedly inhibited NPC cell proliferation, migration and invasion. 34612550 ITCH CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Regulation[miR-22-3p/CBL/β-catenin pathway] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay In this study, we reveal that lower levels of circRNA circ-ITCH are expressed in PTC tissues than in normal adjacent tissues. In summary, our study reveals a novel signaling pathway of circ-ITCH/miR-22-3p/CBL/β-catenin involved in PTC development and progression. Yes Gain-of-functional assays show that circ-ITCH overexpression suppresses PTC cell proliferation and invasion and promotes apoptosis in vitro. Overexpression of circ-ITCH also leads to impaired tumor growth in vivo. 30190130 ITCH CircRNA Homo sapiens Multiple Myeloma Bone marrow Expression[lower expressed] qRT-PCR Circ-ITCH expression was under-expressed in MM patients compared to healthy controls. Yes In U226 cells, cell proliferation was decreased but apoptosis was elevated by circ-ITCH overexpression. 35117187 ITCH CircRNA Homo sapiens Intervertebral Disc Degeneration IDD patients' nucleus pulposus (NP) tissues Interaction(miR-17-5p/SOX4 signaling/ Wnt/β-catenin) Western Blot//qPCR//CCK8//Luciferase Report Assay//Cell Apoptosis Assay Significantly, the expression levels of circITCH were elevated in the IDD patients' nucleus pulposus (NP) tissues relative to that of normal cases. Thus, we conclude that circITCH promotes ECM degradation in IDD by activating Wnt/β-catenin through miR-17-5p/SOX4 signaling. Yes CircITCH promoted apoptosis and decreased proliferation of NP cells. CircITCH contributed to ECM degradation, as demonstrated by increased ADAMTS4 and MMP13 expression and decreased aggrecan and collagen II expression. 34015763 ITCH CircRNA Homo sapiens ovarian carcinoma ovarian carcinoma tissue Expression[lower expressed] CCK8//qRT-PCR In this study, we observed that circular RNA-ITCH was downregulated, while lncRNA HULC was upregulated in ovarian carcinoma. Yes Overexpression of circular RNA-ITCH resulted in inhibited, while overexpression of HULC promoted the proliferation of cells of ovarian cancer cell lines. 32046413 ITCH CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cells Interaction(miR-106b-5p/PDCD4 Axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay Results showed that circ-ITCH was low expressed in ccRCC tissues and cells. Mechanism investigations claimed that circ-ITCH exerted its metastasis-inhibitory activity via sponging miR-106b-5p and regulating the expression of PDCD4. Conclusively, circ-ITCH suppresses ccRCC metastasis by enforcing PDCD4 expression through binding miR-106b-5p. Yes Downregulation circ-ITCH promoted cell migration, but overexpressing circ-ITCH inhibited cell migration and invasion in OSRC-2 and SW839 cells. 33969128 IRF1-AS LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction[IRF1 ] RNA Pull-Down//Western Blot//ISH//CCK8//qRT-PCR//RIP//Luciferase Report Assay//RNA-seq//IHC Furthermore, IRF1-AS was downregulated in ESCC tissues, and low expression correlated with poor prognosis.Mechanistically, IRF1-AS activates IRF1 (Interferon Regulatory Factor 1) transcription through interacting with ILF3 (Interleukin Enhancer Binding Factor 3) and DHX9 (DExH-Box Helicase 9). In turn, IRF1 binds to the IRF1-AS promoter directly and activates IRF1-AS transcription. Global analysis of IRF1-AS-regulated genes indicated that IRF1-AS activates the IFN response in vitro and in vivo. IRF1 knockdown in IRF1-AS-overexpressing cells abolished the antiproliferative effect and activation of the IFN response. Yes Knockdown and overexpression of IRF1-AS revealed that IRF1-AS inhibits oesophageal squamous cell carcinoma (ESCC) proliferation and promotes apoptosis in vitro and in vivo. 31173852 ITGB1-DT LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Interaction(microRNA‑7/HOXB13 ) qRT-PCR//Western Blot The results revealed that LincIN expression was significantly increased in ESCC tissues and cell lines. On the whole, the findings of the present study suggest that LincIN is overexpressed and plays an oncogenic role in ESCC via the regulation of the NF90/miR‑7/HOXB13 axis. The increased expression of LincIN was positively associated with invasion depth, lymph node metastasis, TNM stage and a poor prognosis. Yes Functional assays revealed that the overexpression of LincIN promoted ESCC cell growth, migration and invasion. 33693959 ITGB2-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tumor and cell lines Interaction(miR-328-5p/HMGA1 axis) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//H&E Staining//Colony Formation Assay We found that the expression level of ITGB2-AS1 was significantly higher in ccRCC tumor and cell lines, and highly expressed ITGB2-AS1 was also associated with a poorer prognosis.We further identified and confirmed the miRNA miR-328-5p as a target of ITGB2-AS1, and miR-328-5p negatively regulated the expression of HMGA1 protein. The anti-tumor effect of silencing ITGB2-AS1 could be partially rescued by inhibiting miR-328-5p activity or overexpressing HMGA1, indicating that ITGB2-AS1 promotes the survival and progression of ccRCC by modulating miR-328-5p/HMGA1 axis. We found that the expression level of ITGB2-AS1 was significantly higher in ccRCC tumor and cell lines, and highly expressed ITGB2-AS1 was also associated with a poorer prognosis. Yes Consistently, silencing ITGB2-AS1 inhibited proliferation, promoted apoptosis in ccRCC cell lines, and curbed the tumorigenesis in the Xenograft model, reduced tumorigenesis in a xenograft tumor growth model. 34170494 ITGB2-AS1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tumor tissues and cell lines regulation[miR-4319/RAF1 axis] Western Blot//ISH//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The results showed that ITGB2-AS1 was elevated in both PDAC tumor tissues and cell lines, predicting a poor prognosis in PDAC patients.In conclusion, ITGB2-AS1 promoted PDAC progression via sponging miR-4319 to upregulate RAF1, suggesting the potential therapeutic target ability of ITGB2-AS1 in PDAC. The results showed that ITGB2-AS1 was elevated in both PDAC tumor tissues and cell lines, predicting a poor prognosis in PDAC patients. Yes Knocking down of ITGB2-AS1 suppressed PDAC cell proliferation, invasion, and migration but induced cell apoptosis in vitro. 31957875 JPX LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines regulation[miR-25-3p/SOX4 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay We found that JPX was markedly upregulated, whereas miR-25-3p was markedly downregulated in CC tissues and cell lines, and the expression of JPX was negatively correlated with miR-25-3p in CC tissues.Our study demonstrates that JPX promotes cervical cancer progression through modulating the miR-25-3p/SOX4 axis, and may serve as a potential target for CC therapy. Yes Moreover, overexpression of JPX increased proliferation, migration and invasion of HeLa cells, whereas knockdown of JPX decreased proliferation, migration and invasion of HeLa cells. 32943989 JPX LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Sample of the NSCLC tissues (n=45) and corresponding normal lung tissues (n=45) Interaction(miR-5195-3p/VEGFA axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay//cell invasion assay//IP//Colony Formation Assay JPX and VEGFA were upregulated, and miR-5195-3p was downregulated in NSCLC. JPX is directly bound to miR-5195-3p. JPX regulated NSCLC cell proliferation, apoptosis and EMT by modulating miR-5195-3p. Yes JPX induced proliferation, colony number, invasion, migration, epithelial-mesenchymal transition (EMT), and inhibited apoptosis of NSCLC cells. 33613033 JPX LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma esophageal tissue and cells Interaction(miR-516b-5p/VEGFA Axis) CCK8//qRT-PCR//Western Blot In the present study, we found JPX was highly expressed in esophageal tissue from ESCC patients. Mechanistically, the results showed that JPX functioned as a sponge of miR-516b-5p, which targeted vascular endothelial growth factor A (VEGFA) in ESCC cells. Interactions between miR-516b-5p and JPX or VEGFA were confirmed by luciferase reporter assays. Yes Functional assays demonstrated that JPX promoted ESCC cell proliferation, migration, and invasion in vitro, and accelerated tumor growth in vivo. Inhibition of JPX significantly attenuated the cell growth and mobility ability of ESCC cells in vitro. 35681693 JPX LncRNA Homo sapiens Lung Neoplasms lung cancer metastatic tissues regulation[JPX/miR-33a-5p/Twist1 axis,Wnt/β-catenin signaling] Flow Cytometry//qRT-PCR//Colony Formation Assay//Western Blot We observed that lncRNA JPX was upregulated in lung cancer metastatic tissues and was closely correlated with tumor size and an advanced stage. Mechanically, the JPX/miR-33a-5p/Twist1 axis participated in EMT progression by activating Wnt/β-catenin signaling. We observed that lncRNA JPX was upregulated in lung cancer metastatic tissues and was closely correlated with tumor size and an advanced stage. Yes Functionally, JPX promoted lung cancer cell proliferation in vitro and facilitated lung tumor growth in vivo. 31941509 JPX LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells regulation[miR-944/CDH2 axis] Tunel//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay LncRNA JPX was discovered as highly expressed in OSCC cells. In short, lncRNA JPX contributes to OSCC cell proliferation, migration, and invasion via miR-944/CDH2 axis, which offers a new direction for potential targeted treatment of OSCC. Yes Silencing lncRNA JPX restrained OSCC cell proliferation, migration, and invasion. 32881231 JPX LncRNA Homo sapiens Osteosarcoma OS cells Regulation(Wnt/β-catenin pathway) qRT-PCR//MTT Overexpression of lncRNA JPX into OS cell lines elevated the cell viability and proliferation, which was accompanied by the increased metastasis. We also found that melatonin inhibited the OS progression by suppressing the expression of lncRNA JPX via regulating the Wnt/β-catenin pathway. Yes Overexpression of lncRNA JPX into OS cell lines elevated the cell viability and proliferation, which was accompanied by the increased metastasis. 34547170 JPX LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-33a-5p ) qRT-PCR//Wound Healing Assay//Western Blot In this study, we found that lncRNA JPX was up-regulated in OS tissues and cells.Furthermore, it was verified that JPX acts as a sponge for miR-33a-5p, and that JPX regulated OS cell proliferation, migration and invasion through miR-33a-5p. Moreover, down-regulation of miR-33a-5p in OS contributed to PNMA1 upregulation, and PNMA1 depletion inhibited OS cell proliferation, migration and invasion in vitro. Yes JPX down-regulation was observed to suppress OS cell proliferation, migration and invasion. 36067544 JHDM1D-AS1 LncRNA Mus musculus Brachial Plexus Neuropathies spinal cord tissues regulation[miR-101-3p/DUSP1 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay We found significant downregulated expression of JHDM1D-AS1 and DUSP1 but upregulated expression of miR-101-3p in the spinal cord after tBPI. JHDM1D-AS1 exerted neuroprotective and anti-inflammatory effects in a rat model of tBPI by regulating miR-101-3p/DUSP1 axis. Yes Overexpression of JHDM1D-AS1 had a prominent neuroprotective effect by suppressing neuronal apoptosis and microglial inflammation through reactivation of DUSP1. 33039970 ITGB2-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissue samples and cell lines Regulation[Wnt/β-catenin signalling] Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Transwell Assay The expression levels of ITGB2-AS1 were up-regulated in osteosarcoma tissue samples and cell lines determined by qRT-PCR assay. Taken together, our study suggested that ITGB2-AS1 played critical roles in the development and progression of osteosarcoma via Wnt/β-catenin signalling, indicating that ITGB2-AS1 might be a valuable diagnostic biomarker and potential anticancer therapeutic target for osteosarcoma. Osteosarcoma patients with high ITGB2-AS1 expression had a significantly poor prognosis. Yes In addition, knockdown of ITGB2-AS1 inhibited the proliferation and induced apoptosis of osteosarcoma cells using MTT assay and flow cytometry detection. 30260245 IUR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues interaction[miR-21 ] CCK8//qRT-PCR//Western Blot We found that IUR was down-regulated in ESCC, and low levels of IUR predicted poor survival of ESCC patients.Therefore, IUR may up-regulate PTEN by sponging miR-21 to regulate cancer cell proliferation and apoptosis in ESCC. We found that IUR was down-regulated in ESCC, and low levels of IUR predicted poor survival of ESCC patients. Yes Cell proliferation and apoptosis analysis showed that IUR and PTEN over-expression inhibited cancer cell proliferation and promoted apoptosis; while miR-21 over-expression played an opposite role. 32124090 IUR LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues regulation[downregulates miR-144] Cell Proliferation Assay//qRT-PCR//Western Blot We aimed to explore the possible involvement of IUR in NPC. IUR and PTEN were downregulated, while miR-144 was upregulated in NPC.In conclusion, IUR can downregulate miR-144 to upregulate PTEN in NPC, therefore inhibiting NPC cell proliferation. Yes . Cell proliferation assay showed that overexpression of IUR and PTEN resulted in decreased NPC cell proliferation rate. 32795216 IUR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues interaction[Sponges miR-24 to Upregulate P53] qRT-PCR//Wound Healing Assay//Transwell Assay We found that IUR was downregulated in LSCC. In addition, subcutaneous tumor model in nude mice showed that overexpression of miR-24 attenuated the effects of overexpression of IUR on the expression of p53 and cancer cell proliferation. Yes Cell proliferation assay showed that overexpression of IUR and p53 led to decreased proliferation rate of LSCC cells, while overexpression of miR-24 led to increased proliferation rate of LSCC cells. We also illustrated that overexpression of IUR promoted cell migration and invasion while miR-24 had opposite effects. 33235495 IUR LncRNA Homo sapiens prostate carcinoma PC tissues Interaction[upregulating miR-200] qRT-PCR We observed that IUR was downregulated in PC, and its expression levels decreased with the increase of clinical stages.Therefore, IUR can downregulate ZEB1 by upregulating miR-200 to inhibit PC cell invasion and migration. We observed that IUR was downregulated in PC, and its expression levels decreased with the increase of clinical stages. Yes Cell invasion and migration analysis showed that IUR and miR-200 overexpression resulted in decreased invasion and migration rates. ZEB1 overexpression played an opposite role and attenuated the effects of IUR and miR-200 overexpression 31545930 IUR LncRNA Homo sapiens stomach carcinoma GC tissues regulation[downregulating ROCK1] qRT-PCR//Transwell Assay In this study, the authors showed that IUR was downregulated in GC. IUR is downregulated in GC and inhibits GC cell invasion and migration by downregulating ROCK1. A follow-up study showed that low IUR expression levels predicted poor survival. Yes ROCK1 overexpression resulted in increased GC cell invasion and migration, while IUR overexpression played an opposite role. 32783641 ITIH4-AS1 LncRNA Homo sapiens Colorectal Neoplasms cell lines Regulation[JAK/STAT3 Signaling] ChIP//Western Blot//Co-IP//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay//IF Interestingly, a significant overexpression of ITIH4-AS1 was observed in CRC cell lines relative to normal NCM460 cells. Additionally, we explained that ITIH4-AS1 upregulation in CRC was attributed to downregulation or even depletion of RE1 silencing transcription factor (REST), a presently identified transcriptional repressor for ITIH4-AS1. Meanwhile, the contribution of ITIH4-AS1 to CRC development was validated to rely on the activation of the JAK/STAT3 pathway. More importantly, we verified that FUS interacted with both ITIH4-AS1 and STAT3, and that ITIH4-AS1 evoked nuclear translocation of phosphorylated (p)-STAT3 in CRC through recruiting FUS. In summary, our findings unveiled for the first time that REST downregulation-enhanced ITIH4-AS1 exerts pro-tumor functions in CRC through FUS-dependent activation of the JAK/STAT3 pathway, implying that targeting ITIH4-AS1 may be a novel effective strategy for CRC therapy. Yes Also, we investigated the facilitating role of ITIH4-AS1 in CRC cell growth and metastasis both in vitro and in vivo. 31557619 ITGB8-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction( miR-33b-5p and let-7c-5p/let-7d-5p/ITGA3 and ITGB3) qRT-PCR//RNA-seq//Luciferase Report Assay//Western Blot Here we found that lncRNA ITGB8-AS1 was highly expressed in CRC. Consistently, knockdown of ITGB8-AS1 attenuated the phosphorylation of SRC, ERK, and p38 MAPK. Mechanistically, ITGB8-AS1 could sponge miR-33b-5p and let-7c-5p/let-7d-5p to regulate the expression of integrin family genes ITGA3 and ITGB3, respectively, in the cytosol of cells. Targeting ITGB8-AS1 using antisense oligonucleotide (ASO) markedly reduced cell proliferation and tumor growth in CRC, indicating the therapeutic potential of ITGB8-AS1 in CRC. Furthermore, ITGB8-AS1 was easily detected in plasma of CRC patients, which was positively correlated with differentiation and TNM stage, as well as plasma levels of ITGA3 and ITGB3. Yes Knockdown of ITGB8-AS1 suppressed cell proliferation, colony formation, and tumor growth in CRC, suggesting oncogenic roles of ITGB8-AS1. 34371180 ITGB2-AS1 LncRNA Homo sapiens Breast Neoplasms Regulation[ITGB2] Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Transwell Assay In conclusion, LncRNA ITGB2-AS1 could promote the migration and invasion of breast cancer cells by up-regulating ITGB2. Yes The results of biological function experiments showed that ITGB2-AS1 could promote the migration and invasion of breast cancer. 29941860 HCG11 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction(miRNA-490-3p/MAP3K9 Axis) In Vivo Experiment//IHC//Western Blot//Transfection//qPCR//CCK8//FISH//Luciferase Report Assay//Cell Apoptosis Assay//H&E Staining//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay HCG11 was highly expressed in NPC tissues and was positively associated with tumor stage, lymphatic metastasis, and poor prognosis. Mechanistically, miR-490-3p is a direct target of HCG11, oncogenic functions of HCG11 in NPC cell proliferation and migration can be partially reversed by the miR-490-3p inhibitor. HCG11 significantly increased mitogen-activated protein kinase MAPK kinase 9 (MAP3K9) levels by inhibiting miR-490-3p. Yes Functionally, HCG11 knockdown inhibited proliferation and migration and induced apoptosis of NPC cells. 35463310 HCG11 LncRNA Homo sapiens Atherosclerosis HUVECs Interaction(miR-224-3p/JAK1 Axis) Western Blot//Transfection//qPCR//Flow Cytometry//MTT//Luciferase Report Assay And the levels of HCG11 and JAK1 was enhanced in ox-LDL-induced HUVECs, while miR-224-3p expression was reduced.Moreover, HCG11 could modulate the JAK1 expression via targeting miR-224-3p. The inhibitory effect of HCG11 silencing on cell pyroptosis and inflammation was reversed by miR-224-3p knockdown. Furthermore, overexpression of miR-224-3p could repress the ox-LDL-induced cell pyroptosis and inflammation via regulating JAK1 expression. Knockdown of HCG11 alleviated cell pyroptosis and inflammation induced by ox-LDL via targeting the miR-224-3p/JAK1 axis, indicating that HCG11 could be the latent target of diagnosis or treatment for AS. Yes Additionally, knockdown of HCG11 or miR-224-3p overexpression reversed the ox-LDL-induced cell viability decline and the increase of cell pyroptosis and inflammation-related proteins, including gasdermin D N-terminal (GSDMD-N), Caspase-1, NOD-like receptor family pyrin domain-containing 3 (NLRP3), interleukin 18 (IL-18), and interleukin 1beta (IL-1β). 35931919 HCG11 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Interaction[AKT/mTOR pathway] qRT-PCR//MTT//Transwell Assay//Western Blot More than that, lncRNA HCG11 inhibited phosphoinositide-3 kinase/protein kinaseB (PI3K/AKT) signaling pathway to suppress PCa progression. Our data showed the overexpression of HGC11-inhibited PI3K/AKT signaling pathway by downregulating miR-543 expression, resulting in the suppression of cell growth in PCa. This finding proved a new regulatory network in PCa and provided a novel therapeutic target of PCa. Yes Further investigation revealed that overexpression of HCG11 inhibited cell proliferation, invasion, and migration, whereas induced cell apoptosis by regulating miR-543 expression in vitro and in vivo. 31228307 FOXC2-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(FOXC2) RNA Pull-Down//Western Blot//MeRIP//CCK8//qRT-PCR//RIP//Transwell Assay Here, we found that FOXC2-AS1 expression was significantly elevated in GC tissues and cells, and overexpression of FOXC2-AS1 indicated advanced TNM stage and shorter overall survival in GC patients. Further investigation revealed that FOXC2-AS1 interacted with FOXC2 mRNA and repressed its degradation. FOXC2-AS1 recruited RNA methyltransferase NSUN2 to FOXC2 mRNA, increasing its m5C level and association with YBX1. Here, we found that FOXC2-AS1 expression was significantly elevated in GC tissues and cells, and overexpression of FOXC2-AS1 indicated advanced TNM stage and shorter overall survival in GC patients. Yes FOXC2-AS1 attenuated the proliferation, migration and invasion of GC cells, whereas overexpression of FOXC2-AS1 showed the opposite effects. 34324140 FOXC2-AS1 LncRNA Homo sapiens Atherosclerosis AS patients regulation[miR-1253/FOXF1 axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot We found that FOXC2-AS1 was significantly upregulated in AS patients, which could be induced by ox-LDL and IL-6 in VSMCs. According to the results, we found that FOXC2-AS1 was upregulated in AS patients; furthermore, FOXC2-AS1 overexpression promoted cell proliferation and inhibited cell apoptosis via targeting miR-1253/FOXF1 signaling axis. Yes Furthermore, FOXC2-AS1 overexpression promoted proliferation and inhibited apoptosis in VSMCs. 32271448 FOXC2-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissue and cells Regulation[miR-1253/EZH2 axis] Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay Results stated that lncRNA FOXC2-AS1 was ectopically up-regulated in prostate cancer tissue and cells. Mechanically, we found that miR-1253 targeted FOXC2-AS1 at the 3'‑untranslated regions (UTR), which in turn bind the EZH2 mRNA 3-UTR. Luciferase reporter assay and rescue experiment confirmed the FOXC2-AS1/miR-1253/EZH2 pathway. In conclusion, we confirmed that lncRNA FOXC2-AS1 accelerated the tumor progression of prostate cancer cells by regulating the proliferation and tumor growth through miR-1253/EZH2 axis. The over-expression of FOXC2-AS1 indicates the poor prognosis of prostate cancer patients. Yes Functionally, the gain- and loss-of-functional experiments revealed that FOXC2-AS1 promoted the proliferation and tumor growth of prostate cancer cells in vitro and in vivo. 30389560 FOXC2-AS1 LncRNA Homo sapiens Melanoma melanoma tissues regulation[silencing p15] qRT-PCR//RIP//ChIP It was found that FOXC2-AS1 was upregulated in melanoma tissues, especially those with metastasis or stage II-IV. FOXC2-AS1 stimulates proliferative ability in melanoma via silencing p15. Yes Knockdown of FOXC2-AS1 inhibited viability, and stimulated apoptosis in A375 and sk-mel-110 cells. 32964984 FOXC2-AS1 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and cells Interaction(miR-6868-5p/E2F3 axis.) ChIP//Western Blot//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//Transwell Assay FOXC2-AS1 expression was high in TSCC tissues and cells. In the mechanism, it was verified that H3K27 acetylation (H3K27ac) triggered an increase in FOXC2-AS1 expression. Furthermore, FOXC2-AS1 was identified as a cytoplasmic lncRNA and served as a ceRNA to upregulate E2F3 expression via sponging miR-6868-5p. Yes Functional assays in vitro showed that silencing FOXC2-AS1 restrained cell proliferation, cell cycle, migration, invasion, and EMT. 34358374 FOXC2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue Interaction[silencing p15] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//ChIP In this clinical NSCLC tissue samples, RT-PCR analysis revealed that lncRNA FOXC2-AS1 was up-regulated in the collected NSCLC tissue (Figure 1A, Table 1). In conclusion, the results in this work confirmed that FOXC2-AS1 could aggravate NSCLC oncogenesis through repressing p15 expression via interacting EZH2, which provide new idea for the NSCLC therapeutic strategy. The ectopic high-expression level of FOXC2-AS1 is closely correlated with the limited NSCLC patients' survival. Yes In the functional experiments, the knockdown of FOXC2-AS1 dramatically suppressed the NSCLC cells' (A549, H460) proliferation, accelerated the apoptosis and induced the cycle arrest at G0/G1 phase. 31396359 FOXC2-AC1 LncRNA Homo sapiens Lung Neoplasms LCa tissues Interaction[regulating miR-107] CCK8//qRT-PCR//Transwell Assay//Western Blot In this study, qRT-PCR results indicated that the expression level of FOXC2-AC1 in LCa was considerably higher than that in normal tissues, with statistically significant differences. In addition, miR-107 expression was found significantly reduced no matter in LCa cell lines or in tissues and showed a negative correlation with FOXC2-AC1. Subsequently, luciferase reporter gene assay demonstrated that overexpression of miR-107 significantly attenuated the luciferase activity of the wild-type FOXC2-AC1 vector without reducing the activity of the mutant vector or empty vector, further proving that FOXC2-AC1 could be targeted by miR-107 through this binding site. In addition, rescue experiment also found that FOXC2-AC1 and miR-107 have mutual regulation, which jointly affected the malignant progression of LCa. Compared with patients with low expression of FOXC2-AC1, patients with high expression of FOXC2-AC1 had higher incidence of distant metastasis and lower overall survival rate. Yes Compared with the control group, the cell proliferation, invasion and metastasis capacities of FOXC2-AC1 overexpressing group were considerably enhanced, while opposite results were observed in the FOXC2-AC1 silencing group. 30720176 FNDC3B CircRNA Homo sapiens Stomach Neoplasms cell lines (AGS, SGC‐7901, MGC‐803, and BGC‐823) Interaction[miR‑17‑5p] Western Blot//qPCR//RIP//PCR//IP We showed that circFNDC3B increased migration and invasion in gastric cancer (GC). Ectopic expression of circFNDC3B reduced the level of E‐cadherin protein to promote the epithelial–mesenchymal transition in GC. RNA immunoprecipitation assays and RNA pull‐Expression[down-expression] assays confirmed that circFNC3B increased CD44 expression, which was associated with cell adhesion, via the formation of a ternary complex of circFNDC3B‐IGF2BP3‐CD44 mRNA. These results indicated that circFNDC3B was associated with the degree of malignancy to highlight the specific characteristics of cell invasion. Yes However, Cell Counting Kit‐8 results showed that the overexpression of circFNDC3B inhibited cell proliferation, whereas silencing of circFNDC3B promoted cell proliferation (Figure S2). 30963578 FNDC3B CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC samples and cells Interaction(miR-490-5p/TXNRD1) RNA Pull-Down//Western Blot//ISH//Transfection//qPCR//Flow Cytometry//RIP//Proliferation Assay//PCR//Cell Proliferation Assay//IP//IHC//Invasion Assay//IF We observed that circFNDC3B was upregulated in ESCC samples and cells, as well as ESCC-derived exosomes. CircFNDC3B was a miR-490-5p sponge, and miR-490-5p inhibition reversed the role of exosomal circFNDC3B-downregulating in ESCC cells. TXNRD1 was a miR-490-5p target, and TXNRD1 elevation weakened the anti-cancer function of miR-490-5p upregulation in ESCC cells. Yes CircFNDC3B could be delivered via exosomes in tumor cells, and the colony formation, proliferation, migration, invasion, glycolysis, and in vivo growth ability of recipient cells were weakened after co-incubation with exosomal circFNDC3B-knockdown donor cells. 35703190 FLVCR-AS1 LncRNA Homo sapiens Osteosarcoma OS tissue and cells interaction[miR381-3p/CCND1] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay Prominently higher FLVCR-AS1 expression was found in OS tissue and cells, and was associated with poor prognosis (P<0.05, P<0.01, or P<0.001). FLVCR-AS1 promoted OS growth by upregulating CCND1 expression via downregulation of miR381-3p. Yes Compared with the siCtrl group, 143B and HOS cells of the siFLVCR-AS1 group had significantly lower OD450 values and clone numbers and obviously higher percentages of cells in the G1 phase and apoptosis (P<0.01 or P<0.001). 32021264 FLVCR1-DT LncRNA Homo sapiens Stomach Neoplasms GC tissues ,cell lines Interaction[targeting c-Myc] qRT-PCR//Luciferase Report Assay//Western Blot High expression of FLVCR1-AS1 correlated with poor clinical outcomes and prognosis in patients with GC.The binding sites of micro RNA-155 (miR-155) on FLVCR1-AS1 were predicted using the miRDB program. Luciferase reporter assay was used to validate direct targeting of FLVCR1-AS1 by miR-155. The effects of FLVCR1-AS1 on expressions of c-Myc and p21 were assessed by western blotting. In vivo experiments were performed to analyze the effects of FLVCR1-AS1 on GC tumor growth. High expression of FLVCR1-AS1 correlated with poor clinical outcomes and prognosis in patients with GC. Yes In vivo experiments were performed to analyze the effects of FLVCR1-AS1 on GC tumor growth.FLVCR1-AS1 promoted proliferation and invasion of GC cells by acting as a ceRNA to sponge miR-155. 30899380 FLVCR1-DT LncRNA Homo sapiens Breast Neoplasms BC cells regulation[Wnt/β-catenin pathway,miR-381-3p/CTNNB1 axis] RNA Pull-Down//Tunel//CCK8//qRT-PCR//RIP//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay FLVCR1-AS1 was abnormally up-regulated in BC cells.FLVCR1-AS1 regulates BC malignant behavior via sequestering miR-381-3p and then freeing CTNNB1, implying a promising target for BC therapy. Yes Silencing FLVCR1-AS1 inhibited cell proliferation, migration, invasion, yet accelerating apoptosis. 32518523 FLVCR1-DT LncRNA Homo sapiens Lung Neoplasms Regulation[ Wnt/β-catenin signaling pathway] qRT-PCR In this study, we found that the expression of FLVCR1-AS1 was increased in lung cancer tissues according to The Cancer Genome Atlas database. Similarly, FLVCR1-AS1 was significantly upregulated in lung cancer cell lines.In sum, FLVCR1-AS1 silencing inhibited the proliferation, migration, and invasion of lung cancer cells by inhibiting the activity of the Wnt/β-catenin signaling pathway. Yes Knockdown of FLVCR1-AS1 dramatically reduced the cell proliferation, migration, and invasion of SPCA1 and A549. 30697812 FLVCR1-DT LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[miR-381/RAP2A axis] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results demonstrated that FLVCR1?AS1 was upregulated in CRC tissues and cells, and increased FLVCR1?AS1 expression levels in patients with CRC were associated with poor prognosis.Overall, the findings of the current study suggest that FLVCR1‑AS1 promotes CRC progression via the miR‑381/RAP2A pathway. These findings may provide a novel approach for CRC treatment. The results demonstrated that FLVCR1?AS1 was upregulated in CRC tissues and cells, and increased FLVCR1?AS1 expression levels in patients with CRC were associated with poor prognosis. Yes FLVCR1?AS1 knockdown significantly attenuated the viability, migration and invasion ability of CRC cells. 33313944 FLVCR1-DT LncRNA Homo sapiens Ovarian Neoplasms OSC tissues,blood,cell line Regulation[miR-513/YAP1 signaling] Western Blot//Wound Healing Assay//CCK8//Colony Formation Assay//Transwell Assay In this study, FLVCR1-AS1 expression was upregulated in OSC tissues, serums, and cells.Besides, FLVCR1-AS1 directly bound to miR-513 and downregulated its expression. Moreover, FLVCR1-AS1 reversed the effect of miR-513 on the OSC cell growth, which might be associated with the role of YAP1. Furthermore, in terms of mechanism, FLVCR1-AS1 promoted EMT in OSC cells. Finally, mice models further confirmed that knockdown FLVCR1-AS1 distinctly suppressed cell growth and EMT in vivo. Yes Knockdown FLVCR1-AS1 decreased cell growth, migration, invasion, and EMT, as well as increased apoptosis in OSC cells, whereas, overexpression of FLVCR1-AS1 increased cell proliferation, migration, invasion, and EMT, and decreased apoptosis of OSC cells. 31412903 FLVCR1-DT LncRNA Homo sapiens Osteosarcoma Osteosarcoma tissues,cell lines regulation[wnt/β-catenin pathway] CCK8//qRT-PCR//Western Blot//Transwell Assay LncRNA FLVCR1-AS1 was upregulated in osteosarcoma, which was positively correlated to tumor size, WHO grade and distant metastasis, but negatively correlated to survival of osteosarcoma patients. FLVCR1-AS1 accelerates the progression of osteosarcoma via activating wnt/β-catenin pathway. LncRNA FLVCR1-AS1 was upregulated in osteosarcoma, which was positively correlated to tumor size, WHO grade and distant metastasis, but negatively correlated to survival of osteosarcoma patients. Yes Overexpression of FLVCR1-AS1 markedly suppressed osteosarcoma cells to proliferate, migrate and invade. 33099956 FLVCR1-DT LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells Interaction(miR-381-3p/MAGT1 axis) RNA Pull-Down//Western Blot//Transfection//Tunel//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In CC cells, FLVCR1-AS1 and MAGT1 were upregulated and miR-381-3p was downregulated. FLVCR1-AS1 sponged miR-381-3p, and MAGT1 was targeted by the FLVCR1-AS1/miR-381-3p axis. Yes FLVCR1-AS1 or MAGT1 knockdown or miR-381-3p augment restrained CC cell proliferation, migration and invasion, but facilitated cell apoptosis. 35430713 FLVCR1-DT LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction(miR-23a-5p/SLC7A11) qRT-PCT//Western Blot//Transfection//Migration Assay//CCK8//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The findings suggest that the expression of FLVCR1-AS1 was elevated in CC tissues and cell lines, and that high expression of FLVCR1-AS1 was associated with poor prognosis of CC patients. In addition, via the dual-luciferase reporting assay and RIP assay were confirmed that FLVCR1-AS1 acted as a competitive endogenous RNA to inhibit the expression of microRNA (miR)-23a-5p, and miR-23a-5p targeted the 3'-untranslated region site of Solute carrier family 7 member 11 (SLC7A11) and negatively regulated the expression of SLC7A11. The findings suggest that the expression of FLVCR1-AS1 was elevated in CC tissues and cell lines, and that high expression of FLVCR1-AS1 was associated with poor prognosis of CC patients. Yes In addition, knockdown of FLVCR1-AS1 could inhibit the proliferation and migration, invasion and epithelial-mesenchymal transformation (EMT) of CC cells, as well as accelerating apoptosis, to inhibit the development of CC. 35465835 FLVCR1-DT LncRNA Homo sapiens Glioma GBM tissues,cell lines regulation[regulating miR-30b-3p] CCK8//qRT-PCR//Transwell Assay FLVCR1?AS1 expression was significantly upregulated in GBM tissues compared with adjacent normal brain samples, and was higher in GBM cell lines compared with normal human astrocyte cells. The results from the present study demonstrated that FLVCR1‑AS1 may serve an oncogenic role in GBM and promote disease progression by interacting with miR‑30b‑3p. Yes The results from Cell Counting Kit?8 and Transwell assays confirmed that FLVCR1?AS1?knockdown inhibited GBM cell proliferation and invasion ability. 32626942 FLVCR1-DT LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and PC cell lines Interaction(KLF10 /PTEN/AKT pathway) Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//migration assay//Cell Proliferation Assay//IHC//ChIP FLVCR1-AS1 expression was low in both PC tissues and PC cell lines, and FLVCR1-AS1 downregulation was associated with a worse prognosis in patients with PC. Mechanistic investigations revealed that FLVCR1-AS1 acts as a ceRNA to sequester miR-513c-5p or miR-514b-5p from the sponging KLF10 mRNA, thereby relieving their suppressive effects on KLF10 expression. Additionally, FLVCR1-AS1 was shown to be a direct transcriptional target of KLF10. FLVCR1-AS1 expression was low in both PC tissues and PC cell lines, and FLVCR1-AS1 downregulation was associated with a worse prognosis in patients with PC. Yes Functional experiments demonstrated that FLVCR1-AS1 overexpression significantly suppressed PC cell proliferation, cell cycle, and migration both in vitro and in vivo. 34635142 FOXC2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[Ca2+-FAK signal pathway] qRT-PCR In this study, we observed that lncRNA FOXC2-AS1 was upregulated in CRC tissues, and its high expression indicated the poor survival in CRC patients. These results demonstrated that FOXC2-AS1 enhances FOXC2 mRNA stability to promote CRC proliferation, migration, and invasion by activation of Ca2+-FAK signaling, which implicates that FOXC2-AS1 may represent a latent effective therapeutic target for CRC progression. In this study, we observed that lncRNA FOXC2-AS1 was upregulated in CRC tissues, and its high expression indicated the poor survival in CRC patients. Yes FOXC2-AS1 knockdown suppressed CRC cell growth, invasion, and metastasis in vitro and in vivo. 32513911 FOXCUT LncRNA Homo sapiens gastric adenocarcinoma gastric adenocarcinoma tissues Expression[Expression[highly expressed]-expression] Flow Cytometry//qRT-PCR//MTT//Transwell Assay Expressions of lncRNA FOXCUT in cancer tissues of GA patients in TCGA database were significantly increased (p<0.001). The survival rate of patients with low expressions of lncRNA FOXCUT was significantly increased (p=0.017, p=0.047). LncRNA FOXCUT is closely related to patients' tumor diameter, lymph node metastasis, TNM staging, and differentiation degree (p<0.05). Yes We showed that the inhibition of the expressions of lncRNA FOXCUT can reduce the proliferation and invasion of GA cells and increase apoptosis, which can be used as a potential therapeutic target for GA. 31364114 FLNA CircRNA Homo sapiens Lung Neoplasms lung cancer cells Interaction( miR-486-3p/XRCC1 and CYP1A1) colony Formation Assay//Western Blot//Transfection//qPCR//IF//PCR//Colony Formation Assay//Transwell Assay MiR-486-3p, which has been found to target XRCC1 and CYP1A1, was regulated by circFLNA. CircFLNA was located in the cytoplasm and had a high expression in lung cancer cells.Furthermore, miR-486-3p mimic reversed the effect of circFLNA overexpression on promoting lung cancer cells and tumors and regulating the expressions of miR-486-3p, XRCC1, CYP1A1, and metastasis/apoptosis/proliferation-related factors. Yes Cancer cell viability, proliferation, migration, and invasion were promoted by overexpressed circFLNA, XRCC1, and CYP1A1 but inhibited by miR-486-3p mimic and circFLNA knockdown. The weight of the xenotransplanted tumor was increased by circFLNA overexpression yet reduced by miR-486-3p mimic. 33500536 FOXCUT LncRNA Homo sapiens Endometrial Neoplasms endometrial cancer cells Expression [highly expressed] cell invasion assay//qRT-PCR//Transfection//Migration Assay This study ascertained that lncRNA FOXCUT was highly expressed in endometrial cancer cells. Yes Overexpression of lncRNA FOXCUT promoted EC cell proliferation, invasion, and migration, as well as epithelial-mesenchymal transition (EMT). In addition, overexpression of lncRNA FOXCUT could inhibit the apoptosis of cancer cells and block EC cells in S phase, whereas silencing lncRNA FOXCUT had the opposite effect. 34591391 FOXD2-AS1 LncRNA Homo sapiens Glioma glioma tissues and GSCs Interaction( TAF-1/NOTCH ) RNA Pull-Down//ChIP//Western Blot//Luciferase Report Assay//Microarray//IF LncRNA FOXD2-AS1, TAF-1 and NOTCH1 were found to be elevated in glioma tissues and GSCs, and silencing lncRNA FOXD2-AS1 inhibited stemness and proliferation, while promoting apoptosis and differentiation of GSCs. Mechanistically, lncRNA FOXD2-AS1 elevation promoted glioma in vivo by activating the NOTCH signalling pathway via TAF-1 upregulation. Yes LncRNA FOXD2-AS1, TAF-1 and NOTCH1 were found to be elevated in glioma tissues and GSCs, and silencing lncRNA FOXD2-AS1 inhibited stemness and proliferation, while promoting apoptosis and differentiation of GSCs.LncRNA FOXD2-AS1 overexpression also led to increased NOTCH1 by recruiting TAF-1 to the NOTCH1 promoter region, thereby promoting stemness and proliferation, while impairing cell apoptosis and differentiation. 35419917 FOXD2-AS1 LncRNA Homo sapiens Thyroid Neoplasms Interaction[Sponging miR-7-5p] IP//RIP//Western Blot FOXD2-AS1 was upregulated in thyroid carcinoma tissues and cells.Silencing FOXD2-AS1 inhibited cancer stem cell-like phenotypes and attenuates the anoikis resistance in vitro. Downregulating FOXD2-AS1 represses the tumorigenesis of thyroid carcinoma cells in vivo. High expression of FOXD2-AS1 significantly correlated with clinical stage, recurrence of thyroid carcinoma. Yes Silencing FOXD2-AS1 inhibited cancer stem cell-like phenotypes and attenuates the anoikis resistance in vitro. Downregulating FOXD2-AS1 represses the tumorigenesis of thyroid carcinoma cells in vivo. 31024447 FOXD2-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Interaction[miR-185-5p] CCK8//qRT-PCR//Microarray//cell invasion assay//Colony Formation Assay//EdU Staining FOXD2-AS1 was significantly upregulated in PTC tissues, and high FOXD2-AS1 expression was positively associated with malignant potential factors in PTC patients. In addition, high level of FOXD2-AS1 expression was an unfavorable independent prognostic biomarker for patients with PTC. Bioinformatics analysis indicated that activation of cell cycle and apoptosis pathways might be involved in the oncogenic function of FOXD2-AS1 in PTC. Moreover, we demonstrated that FOXD2-AS1 directly interacted with miR-185-5p as miRNA sponge and overexpression of FOXD2-AS1 partially reversed the suppressive effect of miR-185-5p in TPC cells. FOXD2-AS1 was significantly upregulated in PTC tissues, and high FOXD2-AS1 expression was positively associated with malignant potential factors in PTC patients. In addition, high level of FOXD2-AS1 expression was an unfavorable independent prognostic biomarker for patients with PTC. Yes Moreover, we found that knockdown of FOXD2-AS1 could effectively inhibit PTC cell proliferation and invasion in vitro and suppress tumor growth of PTC in vivo. 31632522 FOXD2-AS1 LncRNA Homo sapiens Gallbladder Neoplasms gallbladder cancer cells regulation[MLH1 promoter methylation] RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//FISH//RIP//EdU Staining//Transwell Assay We found that lncRNA FOXD2-AS1 was highly expressed, while MLH1 was poorly expressed in gallbladder cancer cells.Thus, silencing of lncRNA FOXD2-AS1 suppressed the progression of gallbladder cancer via upregulation of MLH1 by inhibiting MLH1 promoter methylation. Yes Silencing of lncRNA FOXD2-AS1 or overexpression of MLH1 inhibited gallbladder cancer cell proliferation, invasion, and migration, while facilitating cell apoptosis in vitro as well as retarding tumor growth in vivo. 32917950 FOXD2-AS1 LncRNA Homo sapiens Retinoblastoma retinoblastoma tissues and cells Interaction(miRNA-31/PAX9) Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay FOXD2-AS1 was upregulated, and miR-31 was lowly expressed in retinoblastoma. lncRNA FOXD2-AS1 directly bound to miR-31 and regulated miR-31 expression in SO-RB50 cells. Cell proliferation and migration were inhibited by the miR-31 mimic. miR-31 mediated PAX9 expression via directly binding to PAX9 mRNA. A miR-31 inhibitor partially reversed the effect of FOXD2-AS1 knockdown on the proliferation and migration in SO-RB50 cells. FOXD2-AS1 knockdown reduced PAX9 expression in SO-RB50 cells. PAX9 had negative connection with miR-31, and it had positive relationship with FOXD2-AS1. Yes Low expression of FOXD2-AS1 promoted cell proliferation and migration, and upregulation of FOXD2-AS1 inhibited proliferative and migratory abilities. 35782084 FOXD2-AS1 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues regulation[NF-kB and ERK MAPK signaling pathways] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay Compared to the normal tissues and samples, FOXD2-AS1 significantly highly expressed in TSCC tissues and in TSCC samples of TCGA data, and high expression of FOXD2-AS1 was associated with lymphatic metastasis and poor TNM stages. High expression of FOXD2-AS1 promotes TSCC progression through modulating NF-kB and ERK MAPK signaling pathways and is associated with TSCC poor prognosis, it could be a novel therapeutic target and prognostic biomarker for TSCC. Compared to the normal tissues and samples, FOXD2-AS1 significantly highly expressed in TSCC tissues and in TSCC samples of TCGA data, and high expression of FOXD2-AS1 was associated with lymphatic metastasis and poor TNM stages. Yes Downregulation of FOXD2-AS1 inhibited the migration and invasion of SCC-9 and CAL-27 cell lines. 32531865 FOXD2-AS1 LncRNA Homo sapiens laryngeal carcinoma laryngeal cancer tissues Interaction[targeting miR-206] qRT-PCR//Luciferase Report Assay//MTT//Colony Formation Assay : The expression of FOXD2-AS1 in laryngeal cancer tissues was significantly higher than that in normal tissues(t=10.012, P<0.05), and was associated with T staging of laryngeal cancer(χ=6.41, P=0.016). Double luciferase assay showed that FOXD2-AS1 could directly bind to miR-206, thus inhibiting the expression of miR-206. Further MTT assay indicated that inhibiting miR-206 attenuated the suppressing effect of si-FOXD2-AS1 on the proliferation of TU686 cells. The expression of FOXD2-AS1 in laryngeal cancer tissues was significantly higher than that in normal tissues(t=10.012, P<0.05), and was associated with T staging of laryngeal cancer(χ=6.41, P=0.016). Yes FOXD2-AS1 down regulated proliferation activity of TU686 cells(t=9.337, P<0.05). 31163553 FOXD2-AS1 LncRNA Homo sapiens skin melanoma cutaneous melanoma tissues Interaction[phospho-Akt ] CCK8//qRT-PCR//Western Blot//Transwell Assay In our study, FOXD2-AS1 expression has been found to be Expression[Expression[up-expression]-expression]regulated in cutaneous melanoma tissue specimens and cell lines compared with that in normal tissue specimens and normal human epidermal melanocyte, respectively. Furthermore, high expression of FOXD2-AS1 was obviously correlated with deep Breslow thickness, present ulceration, high Clark level and distant metastasis in cutaneous melanoma patients. Yes The results of loss-of-function study showed that inhibition of FOXD2-AS1 sExpression[Expression[up-expression]-expression]presses cutaneous melanoma cell proliferation, migration and invasion through regulating phospho-Akt expression. 30426532 FOXD2-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines Regulation[ miR-485-5p/KLK7 axis] qRT-PCR FOXD2-AS1 was found to observably upregulated in PTC tissues and cell lines. Rescue assays were conducted to verify the function of FOXD2-AS1/miR-485-5p/KLK7 axis in PTC progression. Kaplan-Meier survival analysis revealed that high expression of FOXD2-AS1 was closely correlated with the unfavorable prognosis of patients with PTC. Yes Loss-of-function assays revealed that knockdown of FOXD2-AS1 or KLK7 greatly inhibited PTC cell proliferation and migration, while induced cell apoptosis. 30456805 FOXD2-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Expression[highly expressed] Western Blot//Transwell Assay The expression of FOXD2-AS1 was upregulated in HNSCC. The expression of FOXD2-AS1 was upregulated in HNSCC; it was positively related with the pathological stage as well as with poor prognosis in HNSCC patients. Yes FOXD2-AS1 silencing inhibited HNSCC cell migration and invasion, also influenced the expression of epithelial-mesenchymal transition-related molecules. 32762453 FOXD2-AS1 LncRNA Homo sapiens Pterygium recurrent pterygium tissues interaction[sponging miR-205-5p] CCK8//qRT-PCR//Flow Cytometry//ChIP FOXD2-AS1 expression was up-regulated in recurrent pterygium tissues. In conclusion, FOXD2-AS1 is activated via its H3K27 acetylation and regulates VEGF-A expression by sponging miR-205-5p in recurrent pterygium. Moreover, a high FOXD2-AS1 expression was associated with advanced stages, increased microvessel density and shorter recurrent-free survival. Yes Furthermore, we show that FOXD2-AS1 induced proliferation and inhibited apoptosis in a cell line derived from recurrent pterygia (HPF-R) at least partially through the regulation of the miR-205-VEGF pathway. 33098266 FOXD2-AS1 LncRNA Homo sapiens Esophageal Neoplasms EC tissues regulation[ miR-145-5p/CDK6 axis] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay We found FOXD2-AS1 was significantly upregulated in EC tissues compared with adjacent normal tissues, which was positively correlated with clinicopathological parameters of patients with EC. In conclusion, silening FOXD2-AS1 significantly inhibited the proliferation and invasion of EC cells by regulating the miR-145-5p/CDK6 axis. Yes Downregulation of FOXD2-AS1 inhibited the proliferation and invasion by inducing apoptosis of EC cells. 32524576 FOXD1-AS1 LncRNA Homo sapiens Stomach Neoplasms stomach tissues,cell lines regulation[ PI3K/AKT/mTOR pathway] qRT-PCR Expression of FOXD1-AS1 was low in normal stomach tissues but was upregulated in GC cell lines.In conclusion, FOXD1-AS1 aggravates GC progression and chemoresistance by promoting FOXD1 translation via PIK3CA/PI3K/AKT/mTOR signaling. Yes Silencing of FOXD1-AS1 impaired GC cell proliferation and motility in vitro, and repressed tumor growth and metastasis in vivo. 32460412 FOXD1-AS1 LncRNA Homo sapiens Glioma cell lines Interaction[targeted both miR339-5p and miR342-3p] Western Blot//Wound Healing Assay//qPCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining FOXD1-AS1 was upregulated and directly correlated with the glioma grade, and it was localized in both the nucleus and the cytoplasm of the glioma cell.These data indicated that FOXD1-AS1, a miR339/342 target, affected biological processes via protein eIF5a; thus, it might be considered as a new therapeutic target for glioblastoma. Yes FOXD1-AS1 silencing caused tumor suppressive effects via inhibiting cell proliferation, migration, and apoptosis, while FOXD1-AS1 overexpression resulted in opposite effects. Additionally, in vivo experiments showed that FOXD1-AS1 knockdown reduced tumor volume and weight. 31102349 FOXD1-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC cells and tissues regulation[sustaining FOXD1 expression] RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//FISH//RIP//MTT//IHC//Transwell Assay We found that FOXD1-AS1 was over-expressed in NPC cells and tissues, and was significantly associated with poor survival rate in patients with NPC. We found that FOXD1-AS1 was over-expressed in NPC cells and tissues, and was significantly associated with poor survival rate in patients with NPC. Yes We also found that FOXD1-AS1 promotes cellular proliferation, migration, invasion, and glycolysis, and inhibits apoptosis by upregulating the expression of FOXD1. 33294261 FOXCUT LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[FOXC1/PI3K/AKT Pathway ] qRT-PCR//MTT//Western Blot//Transwell Assay In this study, a novel long noncoding RNA (FOXCUT) was frequently overexpressed in CRC tissues and cell lines.Mechanistically, FOXCUT promotes the expression of FOXC1 to activate PI3K/AKT signaling pathway for its regulation of cell growth and proliferation. Yes Moreover, knockdown of FOXCUT significantly inhibited proliferation and invasion of CRC cell lines and resulted in downregulated expression of the matrix metalloproteinase 1 (MMP-1). 32801872 FOXCUT LncRNA Homo sapiens Nasopharyngeal carcinoma tumor tissues and adjacent tissues Expression(highly expressed) CCK8//qRT-PCR//Transfection The expression level of FOXCUT was significantly increased in NPC tissues as compared with the adjacent tissues (P < 0.001). Compared with NP69 cells, CNE1, CNE2, SUNE2, HER2 and 5-8F cells all exhibited significantly increased expressions of FOXCUT (P < 0.001). In CNE1 cells, transfection with FOXCUT shRNA significantly inhibited cell proliferation and clone formation (P < 0.001), and caused obvious changes in cell morphology. FOXCUT knockdown significantly decreased the expressions of N-cad and vimentin, increased E- cad expression and the contents of MDA and LDH (P < 0.05), reduced vimentin- positive cells and the activity of SOD, and caused a shift of red fluorescent cells to green fluorescent cells and an increased percentage of green fluorescent cells. FOXCUT knockdown also resulted in significantly increased expressions of Bax/Bcl2 and cleaved Cas3/Cas3 and a lowered expression of c-Myc. Yes FOXCUT knockdown significantly decreased the expressions of N-cad and vimentin, increased E- cad expression and the contents of MDA and LDH (P < 0.05), reduced vimentin- positive cells and the activity of SOD, and caused a shift of red fluorescent cells to green fluorescent cells and an increased percentage of green fluorescent cells. FOXCUT knockdown also resulted in significantly increased expressions of Bax/Bcl2 and cleaved Cas3/Cas3 and a lowered expression of c-Myc. 34658347 FLVCR1-DT LncRNA Homo sapiens Cholangiocarcinoma CCA tumor tissues Interaction[sponging miR-485-5p] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay A significantly higher expression level of FLVCR1-AS1 was identified in CCA tumor tissues and the CCA cell lines HuCCT1 and CCLP1 compared with the normal controls. Mechanistically, FLVCR1-AS1 was demonstrated to sponge microRNA-485-5p (miR-485-5p) in human CCA. The expression of miR-458-5p was significantly decreased in CCA tissue compared with normal tissue, and Pearson's correlation analysis revealed that FLVCR1-AS1 expression was negatively correlated with miR-485-5p expression in CCA tissues. Yes Furthermore, FLVCR1-AS1 knockdown inhibited tumor growth in a xenograft model. 31404302 FLG-AS1 LncRNA Homo sapiens Diabetic Retinopathy serum of DR patients Interaction(miR-380-3p/SOCS6 Axis) In Vivo Experiment//Western Blot//Transfection//Tunel//qRT-PCR//Luciferase Report Assay//ELISA Compared to that in healthy controls, FLG-AS1 expression decreased 2.5-fold and miR-380-3p expression increased 2.6-fold in the serum of DR patients. The expression levels of FLG-AS1 and miR-380-3p were negatively correlated in DR patients (r = -0.3772, P = 0.003). FLG-AS1 promoted the expression of SOCS6 by targeting miR-380-3p. Inhibition of miR-380-3p or overexpression of SOCS6 reduced inflammation, oxidative stress, and apoptosis of HG-treated ARPE-19 cells. FLG-AS1 mitigates DR by regulating retinal epithelial cell inflammation, oxidative stress, and apoptosis via the miR-380-3p/SOCS6 axis. Yes Overexpression of FLG-AS1 reduced inflammation, oxidative stress, and apoptosis of HG-treated ARPE-19 cells and alleviated retinal injury in diabetic rats. 35461393 FEZF1-AS1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Regulation[JAK-STAT3 Pathway] CCK8//qRT-PCR//Western Blot FEZF1-AS1 was overexpressed in ovarian cancer tissues compared to adjacent normal tissues.Our study demonstrated that FEZF1-AS1 exerted an oncogenic role in ovarian cancer via modulating JAK-STAT3 pathway. Furthermore, higher expression of FEZF1-AS1 in ovarian cancer patients contributed to poorer prognosis. Yes FEZF1-AS1 knockdown significantly suppressed the proliferation and promoted apoptosis in ovarian cancer cells. 30416194 FGD5-AS1 LncRNA Homo sapiens Colonic Neoplasms CC tissues and cell lines Interaction(miR-497-5p/PD-L1 Axis) CCK8//qRT-PCR//Transwell Assay Specifically, we found that lncRNA FGD5-AS1 and PD-L1 tended to be high-expressed, while miR-497-5p was low-expressed in CC tissues and cell lines compared to the normal adjacent tissues and cells. . Next, we found that lncRNA FGD5-AS1 positively regulated PD-L1 in CC cells by sponging miR-497-5p. Yes Functionally, the data suggested that lncRNA FGD5-AS1 positively regulated while miR-497-5p negatively modulated malignant phenotypes, including cell proliferation, viability, invasion, migration, epithelial-mesenchymal transition (EMT), and tumorigenesis in CC cells. Interestingly, the inhibiting effects of lncRNA FGD5-AS1 ablation on CC development were abrogated by both silencing miR-497-5p and upregulating PD-L1. 35845947 FGD5-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular tumor tissues and cell lines Regulation(miR-873-5p) qRT-PCR We found that the expression of FGD5-AS1 was upregulated in HCC tissues and cell lines. Moreover, the knockdown of FGD5-AS1 suppressed cell proliferation, migration and invasion, and induced apoptosis in HCC cells. Further studies demonstrated that FGD5-AS1 could function as a competitive RNA by sponging miR-873-5p in HCC cells. Moreover, GTPBP4 was identified as direct downstream target of miR-873-5p in HCC cells and FGD5-AS1mediated the effects of GTPBP4 by competitively binding with miR-873-5p. Taken together, this study demonstrated the regulatory role of FGD5-AS1 in the progression of HCC and identified the miR-873-5p/GTPBP4 axis as the direct downstream pathway. It represents a promising novel therapeutic strategy for HCC patients. Yes Moreover, the knockdown of FGD5-AS1 suppressed cell proliferation, migration and invasion, and induced apoptosis in HCC cells. Further studies demonstrated that FGD5-AS1 could function as a competitive RNA by sponging miR-873-5p in HCC cells. 34783233 FGD5-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular Tumor and normal adjacent tissues Interaction(miR-223) qRT-PCR FGD5-AS1 was upregulated in HCC and its high expression indicated poor prognosis of patients. High expression of FGD5-AS1 enhanced HCC cell proliferation and stemness. Knockdown of FGD5-AS1 restrained tumor growth and stemness in mice. FGD5-AS1 directly sponged miR-223 and promoted the expression of ECT2 and FAT1 in HCC. Both knockdown of miR-223 and overexpression of ECT2 and FAT1 reversed FGD5-AS1 silencing-mediated suppression of HCC cell proliferation and stemness. FGD5-AS1 was upregulated in HCC and its high expression indicated poor prognosis of patients Yes Knockdown of FGD5-AS1 restrained tumor growth and stemness in mice. 35366388 FGD5-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues Interaction( miR-142-5p) qRT-PCR//Luciferase Report Assay//RIP First, we found that FGD5-AS1 was markedly up-regulated in OC. Mechanistically, it was revealed that FGD5-AS1 targeted miR-142-5p to repress its expression and function. Furthermore, miR-142-5p has a binding site for 3' UTR of PD-L1, and FGD5-AS1 could positively regulate PD-L1 expression via repressing miR-142-5p. Moreover, its high expression level was associated with positive local lymph node metastasis and higher T stage in OC patients. Yes Gain-of-function and loss-of-function assays demonstrated that FGD5-AS1 facilitated the proliferation, migration, as well as invasion of OC cells. 33974163 FGD5-AS1 LncRNA Homo sapiens Osteosarcoma OSA tissues and cell lines, Interaction(miR-506-3p/RAB3D axis) qRT-PCR//RIP It was demonstrated that the expression of FGD5-AS1 was up-regulated in OSA tissues and cell lines, and its high expression is associated with higher Enneking stage and poorer histological differentiation. The promoting effects of FGD5-AS1 overexpression on OSA cell proliferation and migration could be counteracted by miR-506-3p. Moreover, FGD5-AS1 competitively adsorbed miR-506-3p to repress its expression so as to up-regulate the expression of RAB3D. Yes Gain-of-function and loss-of-function studies suggested that FGD5-AS1 facilitated OSA cells proliferation and migration. 33891267 FGD5-AS1 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[wnt/β-Catenin Pathway] CCK8//qRT-PCR//Western Blot//Transwell Assay FGD5-AS1 was significantly increased in glioma tissues and cells.Our research emphasized FGD5-AS1 acting as an oncogene by regulating wnt/β-catenin signaling pathway, thus providing some novel experimental basis for clinical treatment of glioma. Yes The in vivo tumor growth assay showed that FGD3-AS1 accelerated glioma tumorigenesis with activating wnt/β-catenin pathway. 32801867 FGD5-AS1 LncRNA Homo sapiens Glioblastoma GBM tumor tissues and cells regulation[miR-129-5p/HNRNPK axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay FGD5-AS1 expression was increased in GBM tumor tissues and cells.FGD5-AS1 promoted GBM progression at least partly by regulating miR-129-5p/HNRNPK to activate Wnt/β-catenin signaling, suggesting the potential of FGD5-AS1 as a candidate target to improve GBM therapy. Yes Knockdown of FGD5-AS1 inhibited cell proliferation and invasion in vitro, and slowed tumor growth in vivo. 32585241 FGD5-AS1 LncRNA Homo sapiens Thyroid Neoplasms HUVEC, SW1736 and KAT18 TC cells Interaction(miR-6838-5p/VAV2 Axis) Western Blot//In vivo experiment//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, SW1736 and KAT18 TC cells with high expression of FGD5-AS1 were screened. This effect is achieved through activation of the miR-6838-5p/VAV2 axis. Yes Overexpression of FGD5-AS1 enhanced proliferation, migration, angiogenesis, and permeability of HUVEC. 35528244 FGD5-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC cells Interaction(miR-520a-3p/KIAA1522 axis) RNA Pull-Down//Western Blot//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay As a result, the abnormal high expression of FGD5-AS1 was observed in PC cells.Moreover, FGD5-AS1 was proven to combine with miR-520a-3p directly. It was also confirmed that KIAA1522 could be targeted by miR-520a-3p. Rescue assay results indicated that overexpressed KIAA1522 could reverse the repressive function of silencing FGD5-AS1 on PC progression. Yes And cell proliferative and migratory abilities could be restrained via FGD5-AS1 depletion. 33794727 FGD5-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cell Interaction(miR-497-5p/SEPT2 signaling) qRT-PCR//Luciferase Report Assay//Western Blot Specifically, LncRNA FGD5-AS1 sponged miR-497-5p to upregulate SEPT2 in LSCC cells in a competing endogenous RNA (ceRNA) mechanisms-dependent manner. Interestingly, upregulated LncRNA FGD5-AS1 and downregulated miR-497-5p were observed in LSCC tissues and cells, and LncRNA FGD5-AS1 ablation inhibited cancer progression. Collectively, we conclude that targeting the LncRNA FGD5-AS1/miR-497-5p/SEPT2 signaling cascade may be an alternative strategy to treat LSCC in the clinic. Yes Interestingly, upregulated LncRNA FGD5-AS1 and downregulated miR-497-5p were observed in LSCC tissues and cells, and LncRNA FGD5-AS1 ablation inhibited cancer progression. 34003510 FGD5-AS1 LncRNA Homo sapiens Mouth Neoplasms OC tissues and cells regulation[ FGD5-AS1/ miR-153-3p/MCL1 axis ] Wound Healing Assay//CCK8//qRT-PCR//EdU Staining//Transwell Assay FGD5-AS1 was significantly increased in OC tissues and cells. CCK8 assay, Edu assay, wound healing assay and transwell assay were used to detect the FGD5-AS1/ miR-153-3p/MCL1 axis function on proliferation, migration and invasion in OC cells. Yes Loss of FGD5-AS1 inhibited the proliferation, migration and invasion of OC cells. 32675387 FGD5-AS1 LncRNA Homo sapiens Mouth Neoplasms OSCC tissue and cells Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay FGD5-AS1 expression was aberrantly up-regulated in OSCC tissue and cells.FGD5-AS1 regulates OSCC via competitively binding to miR-520b against USP21. I Yes Knockdown of FGD5-AS1 inhibited cell growth, migration, and invasion, yet promoted apoptosis. 31899825 FGD5-AS1 LncRNA Homo sapiens Osteonecrosis hBMSCs Interaction(miR-296-5p/STAT3 Axis) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay In addition, lncRNA FGD5-AS1 acts as a sponge for miR-296-5p. Also, miR-296-5p directly targets STAT3. More importantly, miR-296-5p and STAT3 can affect the function of lncRNA FGD5-AS1 in Dex-treated hBMSCs. Yes Overexpression of lncRNA FGD5-AS1 promoted cell proliferation and restrained apoptosis in Dex-treated hBMSCs. 35190765 FEZF1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-363-3p/HMGA2] ISH//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Transwell Assay Here, we discovered that FEZF1-AS1 was upregulated in GC tissues and cell lines. In general, our findings clarified the critical regulatory role of FEZF1-AS1/miR-363-3p/HMGA2 axis in GCSC progression, providing a potential therapeutic target for GC. Yes Moreover, FEZF1-AS1 silence also suppressed cell proliferation, viability, invasion, and migration of GCSCs. 32638620 FEZF1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Interaction[Wnt/β-catenin pathway] qRT-PCR//Wound Healing Assay//Cell Cycle Assay//Invasion Assay FEZF1-AS1 was remarkably upregulated in ESCC tissues and cell lines.We also found that β-catenin was upregulated in ESCC tissues, and the level of it was positively correlated with the expression of FEZF1-AS1. Silencing of FEZF1-AS1 could decrease the mRNA and protein level of β-catenin, while overexpression FEZF1-AS1 could lead to the contrary. Yes Silencing of FEZF1-AS1 significantly inhibited the migration and invasion of ESCC cells, while overexpression of FEZF1-AS1 notably accelerated ESCC migration and invasion. 31191005 FEZF1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction[FEZF1-AS1/OTX1/EMT pathway] qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Transwell Assay We verified that FEZF1-AS1 is highly expressed in CRC tissues and cell lines. Mechanistically, we discovered that reduced levels of the lncRNA FEZF1-AS1 inhibited the activation of epithelial-mesenchymal transition (EMT); the overexpression of orthodenticle homeobox 1 (OTX1) partially rescued the FEZF1-AS1-induced inhibition of protein expression. It indicated that FEZF1-AS1 may play a role in the occurrence and development of CRC by regulating the FEZF1-AS1/OTX1/EMT pathway. Furthermore, it was reported that FEZF1-AS1 is located in both the nucleus and cytoplasm of HCT116 cells. Dual-luciferase reporter assays verified that FEZF1-AS1 directly binds miR-30a-5p and negatively regulated each other. Further, we showed that 5'-nucleotidase ecto (NT5E) is a direct target of miR-30a-5p, and the inhibition of miR-30a-5p expression partially rescued the inhibitory effect of FEZF1-AS1 on NT5E. Yes Through functional experiments, we found that reduced levels of FEZF1-AS1 significantly suppressed CRC cell migration, invasion, and proliferation and inhibited tumor growth in vivo. 31270006 FEZF1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-363-3p/PRRX1 pathway) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We demonstrated that FEZF1-AS1 expression was upregulated in CRC, and its silencing reduced CRC cell proliferation, migration, invasion, and EMT. MiR-363-3p could be inhibited by FEZF1-AS1, which inhibitor could reverse the suppressive effect of FEZF1-AS1 silencing on CRC progression. Paired-related homeobox 1 could be targeted by miR-363-3p, and the inhibitory effect of FEZF1-AS1 knockdown on CRC progression could also be eliminated by PRRX1 overexpression. Furthermore, interference of FEZF1-AS1 reduced the tumor growth of CRC in vivo. Yes We demonstrated that FEZF1-AS1 expression was upregulated in CRC, and its silencing reduced CRC cell proliferation, migration, invasion, and EMT. Furthermore, interference of FEZF1-AS1 reduced the tumor growth of CRC in vivo. 34286520 FEZF1-AS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues and cells Interaction(FEZF1-AS1/miR-92b-3p/ZIC5 axis) qRT-PCR//Wound Healing Assay The expression of FEZF1-AS1 and ZIC5 was significantly higher and that of miR-92b-3p was lower in the colon cancer than in the normal colon tissues. According to the prediction, FEZF1-AS1 and ZIC5 might competitively bind to miR-92b-3p, leading to the weakening of the inhibitory impact of miR-92b-3p on ZIC5 and increasing expression of ZIC5, thus further activating the PI3K/AKT signaling pathway, which led to the occurrence and development of colon cancer. Yes FEZF1-AS1 promoted the migration, proliferation, as well as invasion of RKO. 36219353 FEZF1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines and tissues interaction[miR-4443 ] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay In the present study, it was identified that FEZF1?AS1 was significantly upregulated in HCC cell lines and tissues, as determined by reverse transcription?quantitative polymerase chain reaction. Collectively, the present results demonstrated that FEZF1‑AS1 acts as an oncogene by acting as a sponge for miR‑4443. Additionally, it was observed that higher expression of FEZF1?AS1 in patients with HCC indicated poorer prognosis. Yes Furthermore, it was identified that knockdown of FEZF1?AS1 markedly inhibited the proliferation, colony formation, migration and invasion of Hep3B and Huh7 cells, as determined by Cell Counting Kit?8, colony formation and Transwell assays. 30365146 FEZF1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular Regulated[up-regulated] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay lncRNA FEZF1-AS1 may strengthen the growth, migration and invasion of hepatocellular carcinoma cells. Yes In addition, knockdown or overexpression of lncRNA FEZF1-AS1 expression inhibited or enhanced the migration and invasion abilities as well as the levels of adhesion molecules in hepatocellular carcinoma cells. 31550856 FGD5-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell renal cancer tissues regulation[ERK/AKT signalling] Western Blot//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay LncRNA FGD5-AS1 was highly expressed in renal cancer tissues, especially in patients with metastasis.Mechanistically, lncRNA FGD5-AS1 can competitively interact with miR-5590-3p and regulate the downstream signalling of ErkAKT to enhance the malignancy of tumours. Yes This effect facilitated the proliferation, migration, epithelial-mesenchymal transition and invasion of renal cancer cells. Silencing the expression of FGD5-AS1 with FGD5-AS1 siRNA significantly inhibited the malignancy of tumour cells. 32964964 FGD5-AS1 LncRNA Homo sapiens Colorectal Neoplasms cell lines Interaction[sponging miR-302e and upregulating CDCA7] RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay FGD5-AS1 was increased in colorectal cancer cell lines compared to normal cell lines.LncRNA FGD5-AS1 could promote CRC progression through sponging miR-302e and upregulating CDCA7. Yes Inhibition of FGD5-AS1 suppressed cell proliferation, migration, invasion, and accelerated cell apoptosis in CRC. 31332696 FKBP9P1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues regulation[PI3K/AKT signaling] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay FKBP9P1 expression was significantly up-regulated in HNSCC tissues (tumor vs. normal, 1.914 vs. 0.957, t = 7.746, P < 0.001) and cell lines (P < 0.01 in all HNSCC cell lines). Silencing lncRNA FKBP9P1 represses HNSCC progression and inhibits PI3K/AKT (phosphatidylinositol 3 kinase/AKT Serine/Threonine Kinase) signaling in vitro. Besides, the median FKBP9P1 expression of HNSCC tissues (1.677) was considered as the threshold. High FKBP9P1 level was correlated with advanced T stage (P = 0.022), advanced N stage (P = 0.036), advanced clinical stage (P = 0.018), and poor prognosis of HNSCC patients (overall survival, P = 0.002 and disease-free survival, P < 0.001). Yes Knockdown of FKBP9P1 led to marked repression in proliferation, migration, and invasion of HNSCC cells in vitro (P all < 0.01). 32769488 FGD5-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-493-5p/DDX5 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay Expression of FGD5-AS1 in NSCLC tissues and cell lines was up-regulated. FGD5-AS1 directly targeted miR-493-5p, while DDX5 was the target of miR-493-5p in NSCLC cells. Expression of FGD5-AS1 was in association with enlarged tumor size and lymph node metastasis of the patients. Yes Knockdown of FGD5-AS1 led to the inhibition of proliferation, migration, invasion and EMT of NSCLC cells. 33550957 FIRRE LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation(CREB/PFKFB4 ) CCK8//qRT-PCR//Western Blot Here, we disclosed that the FIRRE level was frequently increased in HCC compared to nontumor tissues. Compared with normal liver cells, we also confirmed the upregulated level of FIRRE in HCC cells.Mechanistically, modulating FIRRE level did not affect the stability of PFKFB4 mRNA. FIRRE was mainly distributed in HCC cells' nucleus and promoted PFKFB4 transcription and expression via cAMP-responsive element-binding protein (CREB). PFKFB4 could abolish the effects of FIRRE knockdown on HCC cell proliferation and glycolysis. Notably, the FIRRE high expression was related to malignant clinical features, including advanced TNM stage and tumor size ≥5 cm, and conferred to worse survival of HCC. Yes Functionally, FIRRE knockdown repressed the proliferation and glycolysis of HCCLM3 cells.Overexpression of FIRRE strengthened Huh7 cell proliferation and glycolysis. Notably, FIRRE positively regulated the glycolic enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) expression in HCC cells. 34093813 FIRRE LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines and tissue samples Interaction(MBNL3/PXN ) qRT-PCR In this study, we found that FIRRE, a recently identified cancer-associated lncRNA located on chromosome X, is highly expressed in HCC cell lines and tissue samples, and its expression is positively correlated with poor HCC prognosis. As for the potential mechanism, FIRRE specifically binds to the splicing factor MBNL3 to affect the expression of PXN to regulate the pathological characteristics of HCC cells. In this study, we found that FIRRE, a recently identified cancer-associated lncRNA located on chromosome X, is highly expressed in HCC cell lines and tissue samples, and its expression is positively correlated with poor HCC prognosis. Yes In vitro and in vivo functional analyses showed that FIRRE could promote the proliferation, migration, and invasion of HCC. 35988459 FIRRE LncRNA Homo sapiens Gallbladder Neoplasms 60 GBC and 20 para-carcinoma tissue samples Interaction(miR-520a-3p/YOD1) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//RIP//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//IHC//Transwell Assay FIRRE level was dramatically increased in GBC tissues compared to that in the adjacent non-tumor tissues. Mechanistically, FIRRE modulated YOD1 expression by sponging miR-520a-3p, thus contributing to the development of GBC. High expression of FIRRE was closely related to clinical stage and poor prognosis in GBC patients. Yes Moreover, FIRRE remarkably enhanced proliferation and migration, and inhibited apoptosis of GBC cells. 34168678 FIRRE LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues and cells Regulation[Wnt/β-catenin signaling pathway] qRT-PCR qRT-PCR proved that lncRNA functional intergenic repeating RNA element (FIRRE) was up-regulated in DLBCL tissues and cells. Taken together, FIRRE activated Wnt/β-catenin signaling pathway to facilitate DLBCL cell growth via modulation of the nuclear translocation of β-catenin. Based on Kaplan-Meier analysis, high FIRRE level was associated with the poor overall survival. Yes Subsequently, cell functional assays further revealed that FIRRE functioned as an oncogene by promoting cell proliferation and reducing cell apoptosis in DLBCL. 30739786 FIRRE LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL cells Interaction(PTBP1/Smurf2 ) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay FIRRE was specifically up-regulated in and essentially maintained multiple malignant behaviors of BCR-dependent DLBCL cells. Through the interaction with PTBP1, FIRRE promoted the mRNA decay of Smurf2, a ubiquitin ligase for the degradation BCR protein. Targeting FIRRE was sufficient to regulat Smurf2 and BCR expressions and inhibit DLBCL malignancy both in vivo and in vitro. FIRRE-PTBP1 interaction, by simulating Smurf2 mRNA decay and stabilizing BCR, promotes the development of DLBCL. Yes Targeting FIRRE was sufficient to regulat Smurf2 and BCR expressions and inhibit DLBCL malignancy both in vivo and in vitro. 35416325 Firre LncRNA Mus musculus Neuralgia spinal cord tissue regulation[suppressing HMGB1 expression] qRT-PCR//RNA Pull-Down//RIP FIRRE expression was upregulated in the spinal cord tissue of female CCI mice and LPS-induced microglial cells. Our findings indicated that lncRNA FIRRE downregulation inhibits the secretion of microglial cells-derived proinflammatory cytokines by decreasing HMGB1 expression, thereby relieving neuropathic pain of female mice. Yes The in vivo experiment showed that FIRRE knockdown alleviated neuropathic pain of CCI female mice. 33151463 FGF7-5 LncRNA Homo sapiens Atherosclerosis carotid plaque Regulation RNA Pull-Down//Transfection//RIP//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay Next, lncRNA_FGF7-5 and lncRNA_GLRX3 targeted miR-2681-5p directly to upregulate ERCC4 expression.Taken together, these findings indicated that lncRNA_FGF7-5 and lncRNA_GLRX3 together reduced atherosclerosis-induced apoptosis of HUVECs via targeting miR-2681-5p to increase ERCC4 expression, thereby preventing the formation of carotid plaque and finally inhibiting atherosclerosis progression. Yes Silencing of lncRNA_FGF7-5 and lncRNA_GLRX3 promoted apoptosis and TP53 expression in HUVECs treated with ox-LDL; however, these effects were reversed by ERCC4-overexpression. 36071684 FGF14-AS2 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction[sponging miR-205-5p] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay FGF14-AS2 was down-regulated while miR-205-5p was up-regulated in breast cancer tissues and cells and correlated with tumor stage and size.Moreover, FGF14-AS2 could directly bind to miR-205-5p, and the overexpression of FGF14-AS2 undermined the miR-205-5p induced effects on proliferation, migration, invasion, and apoptosis in breast cancer cells. FGF14-AS2 was down-regulated while miR-205-5p was up-regulated in breast cancer tissues and cells and correlated with tumor stage and size. Yes Functionally, the overexpression of FGF14-AS2 or miR-205-5p knockdown suppressed proliferation, migration, and invasion, and induced apoptosis of breast cancer cells. 31486497 FGF14-AS2 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues regulation[miR-370-3p/FGF14 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Transwell Assay The lncRNA FGF14-AS2 was significantly downregulated in breast cancer tissues; patients with lower FGF14-AS2 expression had advanced clinical stage. Collectively, our findings support a model in which the FGF14-AS2/miR-370-3p/FGF14 axis is a critical regulator in breast cancer metastasis, suggesting a new therapeutic direction in breast cancer. The lncRNA FGF14-AS2 was significantly downregulated in breast cancer tissues; patients with lower FGF14-AS2 expression had advanced clinical stage. Yes In vitro and in vivo assays of FGF14-AS2 alterations revealed a complex integrated phenotype affecting breast cancer cell migration, invasion, and tumor metastasis. 33083023 FGF14-AS2 LncRNA Homo sapiens Colorectal Neoplasms Colorectal Cancer tissues regulation[RERG/Ras/ERK Signaling ] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Via RT-qPCR, we confirmed the downregulation of FGF14-AS2 in collected colorectal carcinoma samples. Taken together, the current study demonstrated FGF14-AS2 as a regulator of colorectal cancer development via downregulation of miR-1288-3p and inactivation of Ras/ERK signaling. Yes Transfection of plasmid containing full length of FGF14-AS2 repressed cell proliferation and induced elevation of cell apoptosis in colorectal cancer cells. 32654025 FGF14-AS2 LncRNA Homo sapiens prostate carcinoma prostate carcinoma tissue and cells Interaction(miR-96-5p/AJAP1 axis) In Vivo Experiment//Western Blot//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//IHC//Bioinformatics Analysis//Transwell Assay FGF14-AS2 was a downregulated lncRNA in prostate carcinoma tissue and cells. FGF14-AS2 could restrain miR-96-5p expression while miR-96-5p hampered AJAP1.Moreover, miR-96-5p mimic presented a cancer promoter role in prostate carcinoma cells. AJAP1 expression level could affect levels of proteins related to epithelial-mesenchymal transition. Yes FGF14-AS2 could effectively decrease the biological behaviors of prostate carcinoma cells, while knock-down of FGF14-AS2 triggered opposite results. In vivo experiment suggested that overexpressing FGF14-AS2 could reverse the promotion of silenced AJAP1 on prostate carcinoma cell metastasis, thus to inhibit tumor growth. 34655124 FGF14-AS2 LncRNA Mus musculus Glioma glioma tissues Interaction(miR-320a/E2F1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay In the present study, we found that FGF14-AS2 expression was significantly elevated in glioma tissues and was associated with poor survival in glioma patients.In addition, FGF14-AS2 was observed to promote glioma progression via the miR-320a/E2F1 axis. In the present study, we found that FGF14-AS2 expression was significantly elevated in glioma tissues and was associated with poor survival in glioma patients. Yes Silencing FGF14-AS2 inhibited the proliferation, migration and invasion ability of glioma cells. In vivo assay showed that silencing FGF14-AS2 led to inhibition of tumour growth. 34659533 FGD5‑AS1/microRNA‑133a‑3p LncRNA Rattus norvegicus Sepsis Mice HL-1 cardiac muscle cells Interaction(FGD5‑AS1/miR‑133a‑3p/AQP1) qRT-PCR//ELISA//RNA Pull-Down//Luciferase Report Assay Compared with the control group, the expression of FGD5‑AS1 was decreased and the expression of miR‑133a‑3p was increased in the sepsis group. FGD5‑AS1 overexpression increased LPS‑induced expression of FGD5‑AS1 and AQP1, decreased the expression of miR‑133a‑3p, and inhibited the expression of the inflammatory cytokines, TNF‑α, IL‑6 and IL‑1β. Dual‑luciferase reporter and miRNA pull‑down assays confirmed the interaction of FGD5‑AS1, miR‑133a‑3p and AQP1. These results indicated that FGD5‑AS1 is the competitive endogenous RNA of miR‑133a‑3p on AQP1, and thus FGD5‑AS1 overexpression may be able to inhibit the inflammatory response in sepsis. Yes FGD5‑AS1 overexpression increased LPS‑induced expression of FGD5‑AS1 and AQP1, decreased the expression of miR‑133a‑3p, and inhibited the expression of the inflammatory cytokines, TNF‑α, IL‑6 and IL‑1β. Dual‑luciferase reporter and miRNA pull‑down assays confirmed the interaction of FGD5‑AS1, miR‑133a‑3p and AQP1. 34498707 FGD5‑AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissue samples and disease model cell lines Interaction(hsa‑miR‑195‑5p/NUAK2 axis) RNA Pull-Down//Western Blot//Migration Assay//CCK8//Luciferase Report Assay//Invasion Assay//Transwell Assay High expression of lncRNA FGD5-AS1 was detected in breast cancer tissue samples and disease model cell lines. It was identified that at a molecular level FGD5‑AS1 serves as a sponge of miR‑195‑5p and alters the expression of its downstream target gene NUAK2. In breast cancer lncRNA FGD5‑AS1 serve a key role in glycolysis and tumor progression via the miR‑195‑5p/NUAK2 axis. Yes Silencing of FGD5‑AS1 led to decreased cell proliferation, migration and invasion. 33880593 FGD5‑AS1 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues and cell lines Interaction( miR‑577/Wnt/β‑catenin signaling) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//MTT//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay The expression level of FGD5-AS1 was upregulated in pancreatic cancer tissues and cell lines. In conclusion, in pancreatic cancer, highly expressed FGD5‑AS1 activated the Wnt/β‑catenin signaling and promoted cancer cell proliferation, migration and invasion via suppression of miR‑577. Yes FGD5‑AS1 knockdown inhibited pancreatic cancer cell proliferation, migration and invasion. 34821374 FGD5-AS1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tisssues, cell lines regulation[miR-153-3p/CITED2 Axis] CCK8//qRT-PCR//Luciferase Report Assay Both gastric cancer cell lines and human tumor samples showed aberrant FGD5-AS1 upregulation. We demonstrated that FGD5-AS1 can regulate human gastric cancer cell functions, possibly through its downstream epigenetic axis of hsa-miR-153-3p/CITED2. Yes Lentiviral-induced FGD5-AS1 knockdown reduced cancer proliferation, 5-FU chemoresistance in vitro, and tumorigenicity in vivo. 32849774 FGD5-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(FZD3) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay FGD5-AS1 was upregulated in GC tissues compared to paracancerous ones. FZD3 was the downstream target of FGD5-AS1. Protein levels of FZD3 and FZD5 were upregulated, while b-catenin, TGF-b and MMP9 were downregulated in GC cells with FGD5-AS1 knockdown. Knockdown of FZD3 abolished the regulatory effects of FGD5-AS1 on malignant phenotypes of GC cells. GC patients expressing a high level of FGD5-AS1 had higher risk of lymphatic metastasis or distant metastasis and worse prognosis than those with a low level. Yes Knockdown of FGD5-AS1 weakened proliferative and metastatic abilities in AGS and SGC-7901 cells. 35848483 FGD5-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung interaction[hsa-miR-107,FGFRL1] CCK8//qRT-PCR//RNA Pull-Down//Luciferase Report Assay High-level expression of FGD5-AS1 was found in NSCLC. Thence, we concluded that lncRNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1. Yes FGD5-AS1 may promote the proliferation of NSCLC cells. 31919528 FOXD2-AS1 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[inhibiting P53] qRT-PCR//RIP//ChIP FOXD2-AS1 was significantly upregulated in glioma tissues and cells. FOXD2-AS1 stimulated the proliferation of glioma by inhibiting P53, thus aggravating the progression of glioma. The expression level of FOXD2-AS1 was positively correlated with tumor size and staging of glioma. Yes The silence of FOXD2-AS1 significantly decreased the viability and colony formation abilities of glioma cells. 32373975 FOXD2-AS1 LncRNA Homo sapiens Glioma cell lines interaction[binding to miR-506-5p] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay The results demonstrated that FOXD2-AS1 was significantly overexpressed in glioma cells, particularly in U251 cells. In conclusion, our data suggested that FOXD2-AS1 contributed to glioma proliferation, metastasis and EMT via competitively binding to miR-506-5p. Yes Knockdown of FOXD2-AS1 in glioma cells significantly inhibited cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) and regulated the expression of CDK2, cyclinE1, P21, MMP7 and MMP9. 33336050 FOXD2-AS1 LncRNA Homo sapiens Glioma glioma tissues Interaction[FOXD2-AS1/miR-31/CDK1 pathway] qRT-PCR//Luciferase Report Assay In this paper, FOXD2-AS1 was found to be upregulated in glioma tissues.Collectively, our results indicated that the FOXD2-AS1/miR-31/CDK1 axis influenced glioma progression, providing a potential new target for glioma patients. In this paper, FOXD2-AS1 was found to be upregulated in glioma tissues. Its level was linked with glioma stage. Moreover, glioma patients expressing high level of FOXD2-AS1 suffered worse prognosis. Yes Further experiments demonstrated that silence of FOXD2-AS1 inhibited proliferation, arrested cell cycle and downregulated cyclin-dependent kinase 1 (CDK1) in human glioma cells. 31347720 FTX LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues and cell lines Expression(highly expressed) In Vivo Experiment//Western Blot//Transfection//Tunel//Migration Assay//CCK8//qRT-PCR//Cell Cycle Assay//IHC//Invasion Assay Reverse transcription-quantitative PCR analysis revealed that the expression levels of FTX were upregulated in thyroid cancer tissues and cell lines compared with those in normal tissues and cell lines, respectively. Survival analysis demonstrated that patients with upregulated FTX expression had a lower survival rate. Yes Functional experiments revealed that the knockdown of FTX inhibited proliferation, cell cycle progression, migration and invasion, and induced apoptosis in thyroid cancer cells, while FTX overexpression accelerated proliferation, migration and invasion, and alleviated apoptosis in thyroid cancer cells. In addition, FTX knockdown significantly inhibited tumor growth in vivo. 34345297 FTX LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC clinical tissue samples and cell lines Expression[lower expressed] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay//IF Here, we report that long non-coding RNA FTX expression level is down-regulated in NSCLC clinical tissue samples and cell lines. Furthermore, we find that FTX overexpression activates the expression of transcription factor FOXA2, an important regulator in lung cancer progression, and we reveal a novel FTX/miR-200a-3p/FOXA2 competing endogenous RNA regulatory axis in lung cancer cells. Yes Ectopic expression of FTX inhibits proliferation and metastasis of lung cancer cells in vitro and in vivo. 32176463 FTX LncRNA Homo sapiens Retinoblastoma RB tissues and cancer cell lines Interaction(miR-320a) In Vivo Experiment//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis In the present study, we found that the expression levels of FTX were notably elevated in RB tissues and cancer cell lines. Yes Overexpression of FTX exacerbated the aggressive phenotypes (cell proliferation, migration and invasion) of RB cells. Downregulation of miR-320a obviously attenuated the inhibitory effects of knockdown of FTX in RB malignant phenotypes, and knockdown of WNK1 also reversed the impacts of miR-320a inhibitor on malignant phenotypes. In vivo experiments further confirmed that knockdown of FTX efficiently prevents tumor growth in vivo. 34720057 Ftx LncRNA Mus musculus Epilepsy hippocampus Regulation[miR-21-5p/SOX7 axis] Western Blot//Tunel//Flow Cytometry//qRT-PCR//Luciferase Report Assay Our results showed that FTX is notably reduced in the hippocampus. Collectively, our study for the first time demonstrated the anti-apoptosis ability of FTX during epileptogenesis and uncovered a novel FTX-mediated mechanism in SE-induced neural apoptosis by targeting miR-21-5p/SOX7 axis, which provides a new target in developing lncRNA-based strategies to reduce SE-induced hippocampal neuron apoptosis. Yes Moreover, the in vivo overexpression of FTX inhibited SE-induced hippocampus neuron apoptosis. 30871773 FTH1P3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Expression[highly expressed] qRT-PCR//Wound Healing Assay//Transwell Assay//Western Blot The results showed that FTH1P3 was highly expressed in NSCLC tumor tissues and NSCLC-derived cell lines.Notably, FTH1P3 knockdown could decrease expression of N-cadherin, vimentin and Snail protein of NSCLC cells, but promote E-cadherin protein expression, which was in accordance with its effect on cell migration and invasion. To sum up, our data demonstrated that FTH1P3 predicts a poor prognosis and promotes metastasis and aggressiveness in NSCLC by inducing EMT, suggesting FTH1P3 may be a promising target for gene therapy of NSCLC. The results showed that FTH1P3 was highly expressed in NSCLC tumor tissues and NSCLC-derived cell lines, and high expression of FTH1P3 was associated with advanced TNM stage and lymph node metastasis. NSCLC patients with high FTH1P3 expression had a poor overall survival relative to patients with low FTH1P3 expression. Yes Through loss-of-function studies, FTH1P3 inhibition was demonstrated to suppress NSCLC cell migration and invasion in vitro. 31933766 FTH1P3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Regulation[SP1/NF-kB pathway] qRT-PCR//Wound Healing Assay//Colony Formation Assay FTH1P3 was significantly upregulated in ESCC tissues and cells (P < 0.001). Silencing of FTH1P3 decreased the expression of specificity protein 1 (Sp1) and NF-kB (p65) in EC9706 and EC1. Yes Knockdown of FTH1P3 notably decreased the proliferation, migration, and invasion capacity of ESCC cells. 30119232 FTH1P3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Regulation[PI3K/Akt/GSK3b/ Wnt/β-catenin signaling] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay The expression level of FTH1P3 was significantly upregulated in OSCC tissues and cell lines. We demonstrated that FTH1P3 acted as a tumor promoter by regulating PI3K/Akt/GSK3β/Wnt/β-catenin signaling and could represent a novel prognostic marker in OSCC patients. Higher expression of FTH1P3 in OSCC tissue was associated with T classification, N classification and TNM stage. Furthermore, Kaplan-Meier survival analysis showed that prognosis of patients with low FTH1P3 expression was much better than that of those with high expression. Cox regression analysis showed that FTH1P3 expression was an independent prognosis-predicting factor for OSCC patients. Yes Loss-function assay showed that knockdown of FTH1P3 significantly suppressed the proliferation, migration and invasion of OSCC cells. 30556871 FTH1P3 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction[microRNA‑145] qRT-PCR//Luciferase Report Assay The results revealed that FTH1P3 was significantly upregulated in cervical cancer tissues compared with normal tissues.miR‑145 was predicted and validated as a direct target of FTH1P3. Moreover, FTH1P3 siRNA partially attenuated the effects of the miR‑145 inhibitor on cell viability and mobility in cervical cancer cells. Yes vitro and in vivo, loss-of-function experiments showed that lncRNA SNHG20 knockdown inhibited proliferative ability, mammosphere-forming ability, ALDH1 expression, stem factors (LIN28, Nanog, Oct4, SOX2) and tumour growth. 31789421 FTH1P3 LncRNA Homo sapiens Glioma glioma tissues Regulation[miR-224-5p/TPD52 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//BrdU The results revealed that FTH1P3 was up?regulated in glioma tissues, and FTH1P3 expression in high?grade glioma tissues was significantly higher compared with that in low?grade glioma tissues. Thus, the miR‑224‑5p/TPD52 axis may be a downstream mechanism of FTH1P3 in glioma progression. The results revealed that FTH1P3 was up?regulated in glioma tissues, and FTH1P3 expression in high?grade glioma tissues was significantly higher compared with that in low?grade glioma tissues. Yes Upregulation of FTH1P3 promoted glioma cell proliferation and inhibited apoptosis. 30221720 FTH1P3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues Expression[highly expressed] qRT-PCR Quantitative real-time PCR (qRT-PCR) showed that FTH1P3 expression was significantly up-regulated in LSCC tissues than that in non-neoplastic tissues. In addition, overexpression of FTH1P3 resulted in an increase in cells in S phase and a decrease in cells in G0/G1 phase, whereas inhibition of FTH1P3 did the opposite effects. Taken together, these results suggested that increased expression of FTH1P3 predicts a poor prognosis and promotes aggressive phenotypes of LSCC by regulating cell proliferation, migration, invasion, apoptosis, and cell cycle, indicating FTH1P3 may serve as a promising therapeutic biomarker for the treatment of LSCC. High FTH1P3 expression was positively correlated with the poor differentiation, high T classification, positive lymph node metastasis, and advanced clinical stage. Overall survival analysis showed that high levels of FTH1P3 predicted a poor prognosis in LSCC patients. Yes Moreover, elevated expression of FTH1P3 was found to increase LSCC cell proliferation, migration and invasion, and to inhibit cell apoptosis, Conversely, knockdown of FTH1P3 suppressed LSCC cell proliferation, migration and invasion, and induced cell apoptosis. 31142627 FTH1P3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC patients and LSCC cells Interaction(miR-377-3p/LDHA Axis) In Vivo Experiment//Western Blot//RIP//qRT-PCR//MTT//Luciferase Report Assay//IHC//ChIP Upregulated FTH1P3 was associated with increased E2F1 expression in LSCC patients. E2F1 was proved to induce FTH1P3 expression in LSCC cells. FTH1P3 modulated miR-377-3p expression by targeting miR-377-3p. Interestingly, LDHA was identified to be a target of miR-377-3p, and FTH1P3 promoted LDHA expression by suppressing miR-377-3p. Yes The results showed that overexpression of FTH1P3 promoted cell viability and glycolysis in LSCC cells, but knockdown of FTH1P3 suppressed this behavior. 33571038 Fscn1 CircRNA Mus musculus Alloimmune Rejection mDCs Expression [highly expressed] Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//PCR//IP Exonic circFSCN1 was highly expressed in the cytoplasm of mature DCs. Yes Knockdown of circFSCN1 using siRNA arrested DCs at an immature state, impaired DC's ability to activate T cells and enhanced Treg generation. 34052126 FRLnc1 LncRNA Homo sapiens Stomach Neoplasms GC cells, tumor tissues, and serum of GC patients Expression(highly expressed) Western Blot//Migration Assay//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Transwell Assay The results of quantitative real-time PCR (qRT-PCR) revealed that the FRLnc1 expressions were up-regulated in GC cells, tumor tissues, and serum of GC patients. Up-regulation of FRLnc1 expression was closely correlated to lymph node metastasis (LNM) and TNM stage with the combination of relevant clinicopathological parameter analysis. Yes The in vitro functional analyses demonstrated that FRLnc1 knockdown by RNA interference suppressed cell proliferation and migration in HGC-27 cells, whereas FRLnc1 overexpression promoted cell proliferation and migration in MKN45 cells. After exosome treatment, the FRLnc1 expression was significantly increased in MKN45 cells, and the MKN45 cells showed increased ability of proliferation and migration. 33971889 FR215775 LncRNA Homo sapiens Rhinitis, Allergic murine primary Th2 cells Expression(highly expressed) Flow Cytometry//qRT-PCR We found that the expression of lncRNA FR215775 was specifically higher in the murine primary Th2 cells. Yes After the knockdown of lncRNA FR215775, the proliferation of CD4+ T cells was inhibited, and the expressions of IL-4 and IL-5 in the cell culture supernatant were significantly decreased (P < 0.001), along with the percentage of Th2 cells (P < 0.05). 35755169 FOXP4‑AS1 LncRNA Homo sapiens Lymphoma, Mantle-Cell MCL patients Interaction(miR‑423‑5p/NACC1 ) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay Our results showed that FOXP4‑AS1 expression was upregulated in MCL patients, and that the high expression of FOXP4‑AS1 was correlated with the unfavorable prognosis of patients. Mechanistically, FOXP4‑AS1 was found to act as a competing endogenous (ce)RNA for miR‑423‑5p to regulate the expression of nucleus accumbens‑associated 1 (NACC1). The negative regulation of FOXP4‑AS1 on miR‑423‑5p compared to that of miR‑423‑5p on NACC1 was determined at the mRNA or protein levels in MCL cells. Our results showed that FOXP4‑AS1 expression was upregulated in MCL patients, and that the high expression of FOXP4‑AS1 was correlated with the unfavorable prognosis of patients. Yes Functionally, while FOXP4‑AS1 downregulation inhibited proliferation, migration and invasion of MCL cells, FOXP4‑AS1 overexpression had promotive effects on these cellular processes. 33416160 FOXP4-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Interaction(MLL2/H3K4me3/FOXP4) CCK8//qRT-PCR//Western Blot Here, we demonstrated that FOXP4-AS1 was significantly increased in ESCC tissues and cell lines, associated with lymph node metastasis and TNM staging. The expression of FOXP4-AS1 and FOXP4 in ESCC tissues was positively correlated. Further research found that FOXP4-AS1, upregulated in ESCC, promotes FOXP4 expression by enriching MLL2 and H3K4me3 in the FOXP4 promoter through a “molecular scaffold”. Moreover, FOXP4, a transcription factor of β-catenin, promotes the transcription of β-catenin and ultimately leads to the malignant progression of ESCC. Here, we demonstrated that FOXP4-AS1 was significantly increased in ESCC tissues and cell lines, associated with lymph node metastasis and TNM staging. Yes Cell function experiments showed that FOXP4-AS1 promoted the proliferation, invasion and migration ability of ESCC cells. 34970490 FOXP4-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC cell lines and tissues Interaction(miR-423-5p/NACC1 axis) CCK8//qRT-PCR//ChIP The results showed that FOXP4-AS1 was highly expressed in CRC cell lines and tissues. Furthermore, FOXP4-AS1 served as a molecular sponge for miR-423-5p, and NACC1 is a direct target of miR-423-5p. MiR-423-5p silencing or overexpression of NACC1 increased proliferation, migration, and invasion of HCT116 cells while suppressing apoptosis. We also found that the upregulation of FOXP4-AS1 was activated by ATF3 in CRC cells. Collectively, our results demonstrated that ATF3-activated FOXP4-AS1 aggravates CRC progression by regulating miR-423-5p/NACC1 axis, indicating a new target for CRC treatment. Yes CRC progression was promoted by the overexpression of FOXP4-AS1 in HTC116 cells and animal models. 35034547 FOXP4-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC cells and tissues Regulation( AKT signaling) qRT-PCR//Western Blot Patients in TCGA cohort with a higher FOXP4-AS1 expression showed a higher disease-free interval (DFI) rate, and the expression of FOXP4-AS1 is shown to be linked to the clinical stage, T stage, N stage, and extraglandular invasion condition of the TC patients. Mechanism analysis indicated that FOXP4-AS1 can play its functions by regulating the AKT signaling pathway, and AKT inhibitor treatment could attenuate the impact of FOXP4-AS1 on PTC progression. Furthermore, FOXP4-AS1 also negatively regulates the expression of its host gene FOXP4. Collectively, we showed that FOXP4-AS1 inhibited PTC progression although AKT signaling and FOXP4-AS1 plays a tumor-suppressor role in PTC tumorigenesis. Patients in TCGA cohort with a higher FOXP4-AS1 expression showed a higher disease-free interval (DFI) rate, and the expression of FOXP4-AS1 is shown to be linked to the clinical stage, T stage, N stage, and extraglandular invasion condition of the TC patients. Yes Functionally, upregulated FOXP4-AS1 inhibited PTC cell proliferation, apoptosis, and migration, whereas it downregulated FOXP4-AS1-promoted progression of PTC. In vivo assay also confirmed the tumor inhibitory effect of FOXP4-AS1 in PTC growth. 35720005 FOXP4-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Regulation( ZC3H12D/H3K27me3/EZH2) qRT-PCR//Colony Formation Assay//Western Blot FOXP4-AS1 and EZH2 expression and H3K27me3 abundance were enhanced while ZC3H12D expression was depressed in HCC tissues and cells. Yes Knockdown of FOXP4-AS1 suppressed biological functions of HCC cells as well as the weight and volume of HCC transplanted tumor. Depleting ZC3H12D reversed the effect of downregulated FOXP4-AS1 on HCC cells. FOXP4-AS1 suppressed ZC3H12D expression via mediating H3K27me3 by recruitment of EZH2. 34545456 FOXP4-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression(highly expressed) Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The expression of FOXP4-AS1 was higher in HCC tissues than adjacent nontumourous tissues, whereas the low expression of FOXP4-AS1 was correlated with optimistic treatment outcomes, which suggested that FOXP4-AS1 may be an independent prognostic biomarker for HCC. The expression of FOXP4-AS1 was higher in HCC tissues than adjacent nontumourous tissues, whereas the low expression of FOXP4-AS1 was correlated with optimistic treatment outcomes, which suggested that FOXP4-AS1 may be an independent prognostic biomarker for HCC. Yes Moreover, the downregulation of FOXP4-AS1 significantly reduced the cell proliferation and clonal abilities and inhibited the invasion, migration, and angiogenesis of hepatoma cells (P < 0.05). 33604387 FTX LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cell lines regulation[miR-335-5p/NUCB2 axis] Western Blot//Tunel//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay RT-qPCR showed that FTX expression was up-regulated in LUAD cell lines.FTX played an oncogenic role in LUAD and contributed to cancer development via targeting miR-335-5p/NUCB2 axis. Yes Loss-of-function assay indicated that FTX accelerated cell proliferation, migration and invasion, while inhibited cell apoptosis in LUAD. 32226311 FTX LncRNA Homo sapiens Osteosarcoma regulation[miR-320a/TXNRD1] qRT-PCR//Luciferase Report Assay QRT-PCR revealed that FTX and TXNRD1 were abnormally upregulated in OS, whereas miR-320a expression was significantly decreased. Taken all the experiment results together, this paper indicated that FTX impacted osteosarcoma cell proliferation and migration by modulating TXNRD1/miR-320a. Yes A series of functional experiments indicated that knockdown of FTX could suppress OS cell proliferation and migration, while facilitating apoptosis ability simultaneously. 31920141 FOXD2-AS1 LncRNA Homo sapiens Glioma glioma tissues Regulation[miR-185-5P/HMGA2 axis and PI3K/AKT signaling pathway] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay LncRNA FOXD2-AS1 was overexpressed in human glioma, and upregulated FOXD2-AS11 expression indicated higher WHO grade (p < 0.05).OXD2-AS1 could regulate the expression of HMGA2 via miR-185-5p.Knockdown of FOXD2-AS1 significantly inhibited proliferation and metastatic potential of glioma cells, whereas endogenous expression FOXD2-AS1 inhibited the glioma cell activity through targeting HMGA2. Yes Knockdown of FOXD2-AS1 significantly inhibited proliferation and metastatic potential of glioma cells, whereas endogenous expression FOXD2-AS1 inhibited the glioma cell activity through targeting HMGA2. 30860979 FTX LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines regulation[miR-214-5p/SOX4 axis ] CCK8//qRT-PCR//Transwell Assay//Western Blot The expression levels of FTX were increased in osteosarcoma tissues and cell lines and negatively correlated with the expression levels of miR-214-5p. FTX could promote proliferation, invasion and inhibited apoptosis by regulating miR-214-5p/SOX4 axis in osteosarcoma, suggesting that FTX might be a potential target for osteosarcoma treatment. Yes sh-FTX inhibited the growth and metastasis of osteosarcoma. 32821116 GACAT3 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression [highly expressed] qRT-PCR//ELISA The results demonstrated that GACAT3 was up-regulated in bladder cancer tissues than that in the paired normal tissues. Downregulation of GACAT3 increased p21, Bax, and E-cadherin expression and silencing these genes could eliminate the phenotypic changes induced by knockdown of GACAT3. Yes Inhibition of cell proliferation, increased apoptosis, and decreased motility were observed in T24 and 5637 cell lines transfected by CRISPR-Cas13 targeting GACAT3. 33537343 GACAT3 LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[GACAT3/miR-3127-5p/ELAVL1 signaling ] qRT-PCR Here, we found that GACAT3 level was aberrantly elevated in glioma tissues and cell lines. Higher GACAT3 expression predicted lower survival rate. Yes Knockdown of GACAT3 suppressed the proliferation, colony formation, migration, and invasion but promoting apoptosis in glioma cells. 30317610 GACAT3 LncRNA Homo sapiens Liver Neoplasms liver cancer tissues Expression[highly expressed] Flow Cytometry//qRT-PCR//MTT//Transwell Assay It was demonstrated that GACAT3 was upregulated in liver cancer tissues. Yes The inhibition of GACAT3 decreased the ability of hepatoma cells to proliferate and migrate, and increased apoptosis of the cells. 32266036 GACAT1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues interaction[targeting microRNA-875-3p] CCK8//qRT-PCR//Flow Cytometry GACAT1 level was clearly enhanced in breast cancer tissues compared to that of the adjacent tissues.The mechanism may be through the regulation of the level of STON2 by adsorbing microRNA-875-3p. Yes Upregulation of GACAT1 promoted the proliferation and cycle of breast cancer cells including MCF-7 and BCap-37. 32194758 GACAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cancer tissues and cell lines Interaction(miR-149) qRT-PCR//Western Blot GACAT1 was highly expressed in cancer tissues and cell lines of OSCC patients (P < 0.01), while miR-149 was low expressed (P < 0.01). LncRNA GACAT1 binds to miR-149 targeting. Knockdown of lncRNA GACAT1 and transfection with miR-149 inhibitor reversed the effect of GACAT1 silencing on OSCC cells. Yes The down-regulation of lncRNA GACAT1 inhibited the proliferation and migration of OSCC cells and promoted apoptosis and autophagy (P < 0.01). The transfection of miR-149 inhibitor had the opposite effect. 34460438 GACAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues interaction[sponging microRNA-422a] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay The present study found that GACAT1 was overexpressed in NSCLC tissues and was associated with poor outcomes in patients with NSCLC. Taken together, these results revealed the novel role of the GACAT1/miR‑422a pathway in the progression of NSCLC cell lines, providing a possible therapeutic strategy for NSCLC treatment. The present study found that GACAT1 was overexpressed in NSCLC tissues and was associated with poor outcomes in patients with NSCLC. Yes Functional experiments revealed that GACAT1 downregulation inhibited proliferation, induced apoptosis and cell cycle arrest of 2 NSCLC cell lines. 33416153 GACAT1 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC samples and cell lines Interaction(miR-149) qRT-PCR//Migration Assay In this reference, we observed that GACAT1 was overexpressed in TSCC samples and cell lines. 25 TSCC specimens, GACAT1 expression was overexpressed in 18 patients (18/25, 72%) compared to non-tumour specimens. We observed that miR-149 expression was down-regulated in TSCC cell lines. Moreover, we observed that GACAT1 expression was negatively correlated with miR-149 expression. GACAT1 overexpression induced TSCC cell growth and migration via regulating miR-149 expression. Yes Ectopic expression of GACAT1 induced cell growth and migration and promoted epithelial to mesenchymal transition in TSCC. In addition, ectopic expression of GACAT1 decreased miR-149 expression in SCC1 cell. 34378327 GABPB1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines regulation[miR-519e-5p/Notch2 axis] qRT-PCR We found that an lncRNA, named GABPB1-AS1, was significantly upregulated in HPV16-positive CC tissues and cell lines. Mechanistically, GABPB1-AS1 acted as a competing endogenous RNA (ceRNA) by sponging miR-519e-5p, resulting in the de-repression of its target gene Notch2 which is well known as an oncogene. Therefore, GABPB1-AS1 functioned as a tumor activator in CC pathogenesis by binding to miR-519e-5p and destroying its tumor suppressive function. GABPB1-AS1 expression in HPV16-positive CC tissues was positively associated with tumor size, lymph node metastasis, and FIGO stage. High expression of GABPB1-AS1 was correlated with a poor prognosis for HPV16-positive CC patients. Yes Functionally, E6-induced GABPB1-AS1 overexpression facilitated CC cells proliferation and invasion in vitro and in vivo. 32844486 GABPB1-AS1 LncRNA Homo sapiens Glioma glioma tissues Interaction( MicroRNA-330/ZNF367/Cell Cycle Signaling Pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Invasion Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Bioinformatics Analysis//Transwell Assay GABPB1-AS1 was highly expressed in the glioma tissues and associated with advanced WHO grades. miR-330 was a target transcript of GABPB1-AS1. miR-330 inhibition restored the malignancy of glioma cells. miR-330 directly bound to ZNF367. ZNF367 was highly expressed in glioma tissues and positively correlated with GABPB1-AS1 expression, and it was relevant to the cell cycle signaling pathway. Yes GABPB1-AS1 knockdown reduced proliferation and invasiveness of glioma cells in vitro and in vivo. 34276213 Gabarapl2 LncRNA Mus musculus Dry Eye Syndromes DED mice Regulation In Vivo Experiment//qRT-PCR//RNA-seq//Bioinformatics Analysis Chrnb2, Gabarapl2, and Usp31 were thereby confirmed as the most significantly altered lncRNAs. Pathway analysis revealed that the neuroactive ligand-receptor interaction signaling pathway was the most enriched, followed by the calcium signaling pathway and cytokine-cytokine receptor interaction. Yes Following treatment of Gabarapl2 siRNA and Chrnb2 siRNA, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 were significantly downregulated in the HCECs. 34957168 FUT8-AS1 LncRNA Homo sapiens Melanoma skin tissues regulation[NRAS/MAPK Signaling] RNA Pull-Down//Western Blot//qRT-PCR//RIP//EdU Staining//Transwell Assay We further confirmed that FUT8-AS1 is downregulated in melanoma. In conclusion, these findings demonstrate that FUT8-AS1 exerts tumor suppressive roles in melanoma via regulating NF90/miR-145-5p/NRAS/MAPK signaling axis. Yes Furthermore, in vivo functional assays demonstrated that FUT8-AS1 represses melanoma growth and metastasis. 34094894 FTX LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Regulation[miR-144/ZFX Axis] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay Figure 1A shows that the expression of LncRNA-FTX in GC tissues was up-regulated compared with those in adjacent normal tissues (p < 0.05). We found that FTX promoted cell proliferation, migration, and invasion, as well as tumor growth, and this effect could latterly be attenuated by miR-144. ZFX attenuated the effects of FTX/miR-144 axis by sponging with miR-144. Yes We found that FTX promoted cell proliferation, migration, and invasion, as well as tumor growth, and this effect could latterly be attenuated by miR-144. 32021248 FTX LncRNA Homo sapiens Stomach Neoplasms tumor tissues interaction[targeting miR-215] CCK8//qRT-PCR//Flow Cytometry//Western Blot We found that the expression of FTX in tumor tissues of 71 GC patients was higher than that in paracancerous tissues, and the prognosis of patients with high FTX was poor. According to these results, this study revealed that the previously neglected FTX-miR2153p-SIVA1 regulatory axis for the regulation of gastric cancer progression, which may be a potential target for the treatment of gastric cancer. We found that the expression of FTX in tumor tissues of 71 GC patients was higher than that in paracancerous tissues, and the prognosis of patients with high FTX was poor. Yes Transferring overexpression plasmid of FTX into gastric cancer cells (MGC-803 and SGC-7901) promoted cell proliferation and the ratio of cells in G0-G1 phase was decreased. Transferring si-FTX to MGC-803 and SGC-7901 led to opposite results. 32271421 FTX LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-192-5p/EIF5A2 Axis] RNA Pull-Down//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay FTX was up-regulated in CRC tissues and cell lines, knockdown of FTX inhibited CRC cell proliferation, migration and invasion in vitro as well as suppressed CRC tumor growth in vivo.LncRNA FTX functioned as an oncogene to contribute to CRC progression by regulating miR-192-5p/EIF5A2 axis, providing a novel insight into the pathogenesis of CRC and a promising therapeutic target for CRC treatment. Yes FTX was up-regulated in CRC tissues and cell lines, knockdown of FTX inhibited CRC cell proliferation, migration and invasion in vitro as well as suppressed CRC tumor growth in vivo. 32280242 FTX LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miRNA-590-5p/RBPJ Axis) qRT-PCR//Western Blot It was found that FTX was upregulated in CRC tissues and cells. Meanwhile, miR-590-5p was the target of FTX, and RBPJ was the direct target of miR-590-5p. Yes Knockdown of FTX or overexpression of miR-590-5p can inhibit the proliferation, migration, and invasion of CRC cells. Besides, silencing of FTX could inhibit the expression of migration and invasion-related proteins in CRC cells. 33389283 FTX LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-214-5p-JAG1 axis) qRT-PCR//Western Blot//IHC//FISH lncRNA FTX was found to be upregulated in CRC tissues by FISH. Mechanistically, lncRNA FTX sequestered miR-214-5p and thus released its repression on JAG1, driving the malignant progression of CRC. Yes The downregulation of endogenous lncRNA FTX expression inhibited CRC cell proliferation, migration, and invasion. 34733921 FTX LncRNA Homo sapiens Carcinoma, Renal Cell RCC specimens and cell lines Interaction(FTX/miR‑4429/UBE2C axis) CCK8//qRT-PCR//RNA-seq The results showed that lncRNA FTX and UBE2C were upregulated in RCC specimens and cell lines.The overexpression of lncRNA FTX in RCC cells upregulated UBE2C. Overall, the present study showed that lncRNA FTX was upregulated in RCC and could significantly promote the proliferative, migratory and invasive capacities, enhancing the viability and accelerating the cell cycle progression of RCC cells by exerting the miRNA sponge effect on miR‑4429 and thus upregulating UBE2C. Yes In addition, the overexpression of lncRNA FTX promoted the cell viability and proliferative, migratory and invasive capacities of RCC cells and accelerated the cell cycle progression. 35866591 FOXP4-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cell lines regulation[miR-136-5p/CBX4 Axis] qRT-PCR//Luciferase Report Assay We found FOXP4-AS1 expression was significantly higher in CC cell lines than in normal cell line. Mechanistically, we found FOXP4-AS1 acts as competing endogenous RNA (ceRNA) for microRNA-136-5p (miR-136-5p) to regulate chromobox 4 (CBX4) expression. Yes Functionally, force FOXP4-AS1 expression increased CC cell proliferation, migration, and invasion, while FOXP4-AS1 knockdown caused opposite effects. 32256085 FOXP4-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues,cell lines Regulation[FOXP4-AS1/FOXP4 axis] Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//ChIP As expected, FOXP4-AS1 was expressed at a higher level in PCa samples compared to adjacent normal samples (Fig. ​(Fig.1c).1c). Consistently, the expression level of FOXP4-AS1 was found to be higher in PCa cell lines compared to human normal prostate epithelial cell RWPE-1 (Fig. ​(Fig.1f).1f). Collectively, we determined that PAX5-induced upregulation of FOXP4-AS1/FOXP4 axis promoted tumorigenesis of PCa. Yes Functionally, high FOXP4-AS1 level was associated with increased cell proliferation and decreased cell apoptosis, indicating that FOXP4-AS1 exerted oncogenic functions in the tumorigenesis of PCa. 31209207 FOXP4-AS1 LncRNA Homo sapiens Lymphoma, Mantle-Cell blood regulation[miR-423-5p/NACC1 pathway] CCK8//qRT-PCR//Transwell Assay Our results showed that FOXP4?AS1 expression was upregulated in MCL patients, and that the high expression of FOXP4?AS1 was correlated with the unfavorable prognosis of patients. In conclusion, FOXP4‑AS1 promotes MCL progression through the upregulation of NACC1 expression by inhibiting miR‑423‑5p. Our results showed that FOXP4?AS1 expression was upregulated in MCL patients, and that the high expression of FOXP4?AS1 was correlated with the unfavorable prognosis of patients. Yes Functionally, while FOXP4?AS1 downregulation inhibited proliferation, migration and invasion of MCL cells, FOXP4?AS1 overexpression had promotive effects on these cellular processes. 33416160 FOXP4-AS1 LncRNA Homo sapiens Sarcoma, Ewing ES tissues Expression(highly expressed) Western Blot//Migration Assay//qRT-PCR//Cell Proliferation Assay//Invasion Assay Herein, we established that FOXP4-AS1 was up-regulated in ES and this correlated with poor prognosis. Herein, we established that FOXP4-AS1 was up-regulated in ES and this correlated with poor prognosis. Yes On the contrary, up-regulation of FOXP4-AS1 promoted the growth, migration, as well as invasion of ES. 34765540 FOXD2‑AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines Regulation[FOXD2‑AS1/miR‑150‑5p/PFN2 axis] CCK8//qRT-PCR//Luciferase Report Assay//Flow Cytometry In the present study, it was identified that FOXD2‑AS1 expression was upregulated in BC tissue, cell lines and sphere subpopulation. Downregulation of FOXD2‑AS1 decreased the percentage of CD44 antigen+/signal transducer CD24- in breast cancer stem cell (BCSC) cells, and decreased the expression of numerous stem factors, including Nanog, octamer‑binding transcription factor 4 (Oct4), and sex determining region Y‑box 2 (SOX2), and inhibited the epithelial‑mesenchymal transition process. FOXD2‑AS1 was identified to be primarily located in the cytoplasm. Using bioinformatics analysis, a reporter gene assay and reverse transcription‑polymerase chain reaction assays, it was demonstrated that microRNA (miR)‑150‑5p was able to bind directly with the 3'‑untranslated region of FOXD2‑AS1 and PFN2 mRNA. miR‑150‑5p mimics decreased the cell proliferation, migration and invasion of BC cells. FOXD2‑AS1 knockdown significantly inhibited the miR‑150‑5p inhibitor‑induced increase in Nanog, Oct4 and SOX2 expression. The miR‑150‑5p inhibitor‑induced increase in N‑cadherin, and decrease in E‑cadherin and vimentin was inhibited by FOXD2‑AS1 knockdown. Profilin 2 (PFN2) expression was significantly upregulated in BC tissues. Additionally, the abnormal upregulation of PFN2 was associated with poor prognosis in patients with BC. FOXD2‑AS1 and PFN2 expression was positively correlated. Collectively, the present results demonstrated the role of the FOXD2‑AS1/miR‑150‑5p/PFN2 axis in the development of BC, and provides novel targets for the treatment of BC, and potential biomarkers for diagnosis and prognosis of BC. Additionally, the abnormal upregulation of FOXD2‑AS1 predicted poor prognosis in patients with BC. Yes Furthermore, downregulation of FOXD2‑AS1 decreased cell proliferation, and migratory and invasive abilities in BC cells, and decreased the growth of transplanted tumors in vivo. 30628646 FOXD2‑AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//FISH//EdU Staining//Transwell Assay Firstly, it was revealed that the expression levels of FOXD2‑AS1 were significantly upregulated in OS tissues and cells, compared with in adjacent tissues and normal cells, as determined using reverse transcription‑quantitative polymerase chain reaction. Notably, the overall survival of patients with relatively high FOXD2‑AS1 expression in OS tissues was significantly lower than that of patients with relatively low expression, as determined using Kaplan‑Meier analysis. Yes Knockdown of FOXD2‑AS1 inhibited the proliferation, migration and invasion of OS cells. 31115575 FOXD2-AS1 LncRNA Homo sapiens Breast Neoplasms cell lines regulation[FOXD2-AS1/S100A1/Hippo axis ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay The results indicated that FOXD2?AS1 expression was upregulated in breast cancer cell lines, and that FOXD2?AS1 downregulation significantly inhibited the proliferation, migration and invasiveness of MCF?7 and MDA?MB?468 cells. On the whole, the findings of the present study suggest that the FOXD2‑AS1/S100A1/Hippo axis is involved in the tumorigenesis and progression of breast cancer. Yes The results indicated that FOXD2?AS1 expression was upregulated in breast cancer cell lines, and that FOXD2?AS1 downregulation significantly inhibited the proliferation, migration and invasiveness of MCF?7 and MDA?MB?468 cells. 32945354 FOXD2-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Expression [highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Cell Apoptosis Assay//Transwell Assay lncRNA FOXD2-AS1 was upregulated in breast cancer tissues and cells and increased cell drug resistance to ADR. Yes Downregulation of lncRNA FOXD2-AS1 inhibited invasion and migration of MCF-7/ADR cells, promoted apoptosis, increased chemosensitivity of MCF-7/ADR cells, and inhibited the activity of PI3K/AKT signaling pathway in MCF-7/ADR cells. 34873418 FOXD2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC samples and cell lines Interaction( miR-204-3p) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay In our work, we found that lncRNA FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) was significantly increased in clinical ESCC samples and cell lines. Through bioinformatics analysis and luciferase reporter assays, microRNA (miR)-204-3p was proved to be a target of FOXD2-AS1. We further confirmed that FOXD2-AS1 was the upstream inhibitor of miR-204-3p and the down-regulation of miR-204-3p reversed the repressive effects of low expression of FOXD2-AS1 on ESCC progression. In addition, inhibition of FOXD2-AS1 effectively suppressed the tumor growth. Yes In addition, inhibition of FOXD2-AS1 effectively suppressed the tumor growth. 35778646 FOXD2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[miR-25-3p/Sema4C axis] qRT-PCR//Transwell Assay In this study, we further confirmed the up-regulation of FOXD2-AS1 in CRC patients and showed that high FOXD2-AS1 level predicted poor survival.FOXD2-AS1 may regulate the miR-25-3p/Sema4C axis to promote the invasion and migration of CRC cells. In this study, we further confirmed the up-regulation of FOXD2-AS1 in CRC patients and showed that high FOXD2-AS1 level predicted poor survival. Yes Transwell assay showed that FOXD2-AS1 and Sema4C over-expression led to the increased invasion and migration rates of CRC cells. 31908535 FOXD2-AS1 LncRNA Homo sapiens Osteoarthritis cartilage tissues Interaction[sponging miR-27a-3p] qRT-PCR In the present study, we showed FOXD2-AS1 expression was upregulated and positively associated with the severity of OA patients. Mechanistically, we found that FOXD2-AS1 upregulated the expression level of TLR4 by sponging miR-27a-3p. In addition, we revealed that miR-27a-3p mimics could abolish the effects of FOXD2-AS1 overexpression on cell proliferation, inflammation, and ECM degradation in chondrocytes. Therefore, we demonstrated that FOXD2-AS1 could play a crucial role in the progression of OA, at least partially, by regulating miR-27a-3p/TLR4 axis. Yes FOXD2-AS1 overexpression induced cell proliferation, inflammation and extracellular matrix (ECM) degradation in chondrocytes. 30945573 FOXD2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation[Wnt/β-catenin signaling pathway] qRT-PCR Mechanistically, FOXD2-AS1 was found to be activated by the transcription factor EGR1. Furthermore, FOXD2-AS1 could activate the Wnt/β-catenin signaling pathway. The mechanism contributed to the interaction between FOXD2-AS1 and Wnt/β-catenin signaling pathway was analyzed. It was uncovered that FOXD2-AS1 enhanced the activity of Wnt/β-catenin signaling pathway by epigenetically silencing the inhibitor of Wnt/β-catenin signaling pathway (DKK1). Rescue assays demonstrated that DKK1 and Wnt/β-catenin signaling pathway involved in FOXD2-AS1-mediated HCC progression. Yes Functionally, silenced FOXD2-AS1 efficiently suppressed HCC progression by regulating cell proliferation, apoptosis, migration and epithelial-mesenchymal transition (EMT). 30929558 FOXD2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues Regulation[MiR-185/AKT Axis] Western Blot//Wound Healing Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Transwell Assay FOXD2-AS1 was significantly upregulation in hepatocellular carcinoma tissues.FOXD2-AS1 knockdown suppressed Bel-7401 cell biological activities (proliferation, invasion, and migration) with miR-185 overexpression and AKT depressing in cell expression. Yes FOXD2-AS1 knockdown suppressed Bel-7401 cell biological activities (proliferation, invasion, and migration) with miR-185 overexpression and AKT depressing in cell expression. 31841454 FOXD2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[silencing CDKN1B(p27) via EZH2] RNA Pull-Down//IHC//Western Blot//qRT-PCR//RIP//Cell Viability Assay//Cell Cycle Assay//Colony Formation Assay//ChIP The data indicated that FOXD2-AS1 expression was increased in HCC specimens and cell lines.Our results revealed that FOXD2-AS1 could epigenetically silence CDKN1B by recruiting EZH2 to CDKN1B promoter region. Knocking down CDKN1B could restore the carcinogenic effect of FOXD2-AS1 on HCC. Furthermore, aberrant expression was correlated with tumor number and tumor size in HCC patients. Yes Silencing FOXD2-AS1 arrest cell cycle in the G0/G1 phase, inhibited colony formation, cell proliferation and suppressed the in vivo growth of subcutaneous tumors. 31004581 FOXD2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells regulation[miR-206/MAP3K1 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay We found that FOXD2-AS1 was significantly upregulated in HCC cells in comparison to normal human liver cells, LO2. In conclusion, this work implies FOXD2-AS1 accelerates HCC progression through sponging miR-206 and regulating MAP3K1 expression. Yes Furthermore, the inhibition of FOXD2-AS1 repressed HCC cell proliferation, enhanced cell apoptosis, and restrained cell invasion and migration. 32558350 FOXD2-AS1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cell lines Interaction(miR-4492) CCK8//Luciferase Report Assay//Invasion Assay//Migration Assay The results suggested that lncRNA FOXD2-AS1 was upregulated in ovarian cancer tissues and cell lines. lncRNA FOXD2-AS1 was confirmed to directly target miR-4492. The expression of lncRNA FOXD2-AS1 and miR-4492 exhibited a negative correlation. Yes si-FOXD2-AS1 was able to inhibit the proliferation, migration and invasion of ovarian cancer cells. 33717250 FOXD2-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] qRT-PCR//MTT//Colony Formation Assay//Western Blot We found that FOXD2-AS1 was significantly highly expressed in OSCC tissues, and correlated with poor pathological grade and prognosis in patients with OSCC. We found that FOXD2-AS1 was significantly highly expressed in OSCC tissues, and correlated with poor pathological grade and prognosis in patients with OSCC. Yes Cell viability and clone formation ability were significantly inhibited after the knockdown of FOXD2-AS1. 33103475 FOXD2-AS1 LncRNA Homo sapiens Osteosarcoma OS tissue and cell lines Interaction[repressing p21] ChIP//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In present research, the level of FOXD2-AS1 was significantly up-regulated in the OS tissue and cell lines compared to corresponding controls. Mechanistically, FOXD2-AS1 inhibited the expression of p21 via interacting with EZH2 to silence p21 gene expression. Overall, we conclude that FOXD2-AS1, induced by transcription factor HIF-1α, acts as an oncogene in the OS tumorigenesis and FOXD2-AS1 interacts with EZH2 to silence p21 protein. This finding could provide a novel insight and potential therapeutic target for the OS. The aberrant high-expression of FOXD2-AS1 indicated the poor clinical prognosis of OS patients. Yes Functionally, the knockdown of FOXD2-AS1 could repress the malignant biological properties of OS cells in vitro and vivo, including proliferation, invasion, apoptosis and tumor growth. 31228799 FOXD2-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma patients and cell line Interaction( FOXD2-AS1/m6A/FOXM1 complex ) qRT-PCR//Western Blot Clinical data unveiled that osteosarcoma patients with higher FOXD2-AS1 expression had a poorer overall survival rate compared to those with lower FOXD2-AS1 expression. Mechanistically, a remarkable m6A-modified site was found on the 3'-UTR of FOXD2-AS1, and m6A methyltransferase WTAP (Wilms' tumor 1 associated protein) promoted the methylation modification, thus enhancing the stability of FOXD2-AS1 transcripts. Furthermore, FOXD2-AS1 interacted with downstream target FOXM1 mRNA through m6A sites, forming a FOXD2-AS1/m6A/FOXM1 complex to heighten FOXM1 mRNA stability. Clinical data unveiled that osteosarcoma patients with higher FOXD2-AS1 expression had a poorer overall survival rate compared to those with lower FOXD2-AS1 expression. Yes Functional research illuminated that FOXD2-AS1 accelerated the migration, proliferation and tumor growth in vitro and in vivo. 35356854 FOXD2-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Interaction[downregulating CDX1] CCK8//qRT-PCR//EdU Staining FOXD2-AS1 was upregulated in CC tissues relative to those of para-tumor tissues, especially in those with larger tumor size and advanced tumor staging.FOXD2-AS1 is upregulated in CC and its high level predicts a poor prognosis of CC patients. It accelerates the malignant progression of CC via negatively regulating CDX1 level. FOXD2-AS1 was upregulated in CC tissues relative to those of para-tumor tissues, especially in those with larger tumor size and advanced tumor staging. Yes The silence of FOXD2-AS1 attenuated SiHa and HeLa cells to proliferate. 31841177 FOXD2-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cells and tissue Interaction(METTL3) Western Blot//Transfection//MeRIP//Migration Assay//qRT-PCR//RIP//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay//ChIP Results illuminated that FOXD2-AS1 expression was significantly upregulated in cervical cancer cells and tissue, which was closely correlated to the unfavorable prognosis. Mechanistically, m6A methyltransferase methyltransferase-like 3 (METTL3) enhanced the stability of FOXD2-AS1 and maintained its expression. Moreover, FOXD2-AS1 recruited lysine-specific demethylase 1 (LSD1) to the promoter region of p21 to silence its transcription abundance. Results illuminated that FOXD2-AS1 expression was significantly upregulated in cervical cancer cells and tissue, which was closely correlated to the unfavorable prognosis. Yes Functionally, gain and loss-of-function assays showed that FOXD2-AS1 promoted the migration and proliferation of cervical cancer cells. Besides, FOXD2-AS1 silencing repressed the tumor growth in vivo. 34589576 FOXD2-AS1 LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[miR-185-5p/CCND2 axis] qRT-PCR FOXD2-AS1 was upregulated in glioma tissue, cells, and sphere subpopulation.We also revealed that FOXD2-AS1 was mainly located in cytoplasm and microRNA (miR)-185-5p both targeted FOXD2-AS1 and CCND2 messenger RNA (mRNA) 3'-untranslated region (3'-UTR). miR-185-5p was downregulated in glioma tissue, cells, and sphere subpopulation. Downregulation of miR-185-5p was closely correlated with poor prognosis of glioma patients. In addition, miR-185-5p mimics decreased cell proliferation, migration, invasion, stemness, and EMT in glioma cells. CCND2 was upregulated in glioma tissue, cells, and sphere subpopulation. Upregulation of CCND2 was closely correlated with poor prognosis of glioma patients. CCND2 knockdown decreased cell proliferation, migration, invasion, and EMT in glioma cells. In glioma tissues, CCND2 expression was negatively associated with miR-185-5p, but positively correlated with FOXD2-AS1. FOXD2-AS1 knockdown and miR-185-5p mimics decreased CCND2 expression. Inhibition of miR-185-5p suppressed FOXD2-AS1 knockdown-induced decrease of CCND2 expression. Overexpression of CCND2 suppressed FOXD2-AS1 knockdown-induced inhibition of glioma malignancy. Yes Downregulation of FOXD2-AS1 decreased cell proliferation, migration, invasion, stemness, and epithelial-mesenchymal transition (EMT) in glioma cells and inhibited tumor growth in transplanted tumor. 30520141 FOXD2-AS1 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction[sponging miR-185 through targeting AKT1] ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In this study, we found that FOXD2-AS1 expression was significantly up-regulated in both glioma tissues and cell lines. Mechanistically, our results showed that FOXD2-AS1 may act as an endogenous sponge by competing for miR-185, thereby regulating the targets of this miRNA. Taken together, our data firstly demonstrated that CREB1-induced FOXD2-AS1 contributed to glioma progression by upregulating AKT1 via competitively binding to miR-185, providing a novel strategy for targeting FOXD2-AS1 as a potential biomarker and a therapeutic target in glioma patients. High FOXD2-AS1 expression was significantly correlated with advanced WHO grade, KPS score and the shorter survival time of glioma patients. Yes Functional investigations revealed that knockdown of FOXD2-AS1 significantly suppressed glioma cells proliferation, migration, invasion and EMT, and promoted apoptosis. 30553445 FOXD3-AS1 LncRNA Mus musculus Reperfusion Injury brain tissues regulation[ miR-765/BCL2L13 axis] Western Blot//Tunel//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay The up-regulation of FOXD3-AS1 and down-regulation of miR-765 were found in both mouse brains after cerebral ischemia/reperfusion (I/R) and neuroblastoma cells of neuro-2A (N2a) after oxygen-glucose deprivation/reoxygenation (OGD/R). We verified a critical signaling pathway of FOXD3-AS1/miR-765/BCL2L13 in regulating cerebral ischemia/reperfusion injury. Yes Furthermore, we found that neurological deficits and brain injury induced by I/R in vivo were attenuated by FOXD3-AS1 knockdown. 33068927 FOXD3-AS1 LncRNA Homo sapiens Colonic Neoplasms CRC tissues and cells Interaction[CRC tissues and cells] Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay Quantitative real-time polymerase chain reaction showed the overexpression of FOXD3-AS1 in both CRC tissues and cells.In conclusion, FOXD3-AS1 promotes CRC progression by regulating miR-135a-5p/SIRT1 axis, shedding lights on the way to CRC treatments. According to the survival analysis of The Cancer Genome Atlas database, FOXD3-AS1 upregulation implied lower survival rate of patients with CRC. The Kaplan-Meier method demonstrated the prognostic value of FOXD3-AS1 for patients with CRC. Yes To explore the effect of FOXD3-AS1 on CRC progression, loss-of-function experiments were carried out, whose results indicated that knockdown of FOXD3-AS1 suppressed cell proliferation, migration, and invasion, inhibited cell cycle and promoted cell apoptosis in vitro. In vivo experiments affirmed that FOXD3-AS1 affected tumor growth. 31058315 FOXD3-AS1 LncRNA Homo sapiens skin melanoma cutaneous melanoma cells and tissues Interaction[miR-325/MAP3K2] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay LncRNA FOXD3-AS1 highly expressed in cutaneous melanoma cells and tissues.LncRNA FOXD3-AS1 could promote proliferation, invasion and migration of cutaneous malignant melanoma via regulating miR-325/MAP3K2 axis. Yes When LncRNA FOXD3-AS1 was knockdown, proliferation, invasion and migration of cutaneous malignant melanoma, and tumor weight was inhibited, and cell cycle was arrested. Tumor volume and weight were measured to confirm the effect of sh-FOXD3-AS1 in vivo. 31541886 FOXD3-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue samples and cell lines Interaction(miR-135a-5p/CDK6 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis FOXD3-AS1 was significantly overexpressed in NSCLC tissue samples and cell lines compared with normal tissue samples and cells. The luciferase reporter assay demonstrated the direct binding interaction between FOXD3-AS1 and miR-135a-5p. It was also demonstrated that miR-135a-5p could bind to the 3' untranslated region of cyclin-dependent kinase 6 (CDK6) and negatively modulate its transcription. Yes FOXD3-AS1 silencing expression significantly inhibited A549 and H1229 cell proliferation while inducing apoptosis compared with sh-NC group. Moreover, FOXD3-AS1 silencing led to the upregulation of miR-135a-5p in A549 and H1229 cells compared with sh-NC group 34733371 FOXP1-AS80 LncRNA Homo sapiens Nasopharyngeal carcinoma interaction[miR-423-5p ] qRT-PCR//Luciferase Report Assay//Western Blot The expression of FOXP4-AS1 was up-regulated in 80 cases with NPC, and these patients with a poor prognosis. FOXP4-AS1upregulated STMN1 by interacting with miR-423-5p as a competing endogenous RNA (ceRNA) to promote NPC progression. The expression of FOXP4-AS1 was up-regulated in 80 cases with NPC, and these patients with a poor prognosis. Yes Functionally, high expression of FOXP4-AS1 in NPC was connected with promoted cell proliferation and inhibited apoptosis. Moreover, FOXP4-AS1 is located in the cytoplasm of CNE1 (NPC cell lines). 32767327 Foxp1 LncRNA Mus musculus Carcinoma, Renal Cell RCC tissues and cells Interaction(miR-423-5p/U2AF2 axis ) ISH//Migration Assay//CCK8//qRT-PCR//Invasion Assay//Transwell Assay Firstly, we demonstrated the characterization and expression of circFOXP1 in RCC tissues and cells.To sum up, our study partially demonstrated that the novel ZNF263/circFOXP1/miR-423-5p/U2AF2 axis has a role in RCC progression. Yes Next, by conducting a serial experiment, we found that downregulated circFOXP1 inhibited cell proliferation, migration, invasion, and the Warburg effect. 34514002 FOXO3 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer (BC) tissues regulation[Regulating MiR-9-5p/TGFBR2] qPCR//Western Blot//PCR//IF We found that circ-FOXO3 was significantly down-regulated in bladder cancer (BC) tissues compared to normal bladder tissues. Furthermore, circ-FOXO3 regulates TGFBR2 expression through sponging miR-9-5p in BC cell lines. Yes We also found that circ-FOXO3 overexpression inhibited cell proliferation, migration and invasion in BC cell lines. 32612392 FOXO1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and corresponding adjacent tissues,cell lines(A549, H460, HCC827 and H129IMR-90) Regulation[PI3K/AKT signaling pathway] Western Blot//Migration Assay//qRT-PCR//MTT//cell invasion assay LncFOXO1 was down-regulated in lung cancer tumor tissues and cells. LncFOXO1 inhibited lung cancer cell proliferation, metastasis, and induced apoptosis through down-regulating PI3K/AKT pathway. Yes Knockdown of lncFOXO1 significantly promoted A549 cells viability, colony formation and invasion. 31217928 FOXF1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Expression[lower expressed] Flow Cytometry//qRT-PCR//MTT The expression of FENDRR was low in NSCLC tissues and cells in contrast to control tissues and cells Yes FENDRR enhancement could inhibit the proliferation ability and advance cell apoptosis of A549 cells. 31749883 FOXD3‑AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction(miR‑128‑3p/LIMK1 axis ) Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU//IHC//Transwell Assay OXD3‑AS1 expression was significantly increased in CC tissues and cell lines compared with adjacent healthy tissues and normal cervical epithelial cells, respectively. Moreover, the results demonstrated that FOXD3‑AS1 targeted and negatively regulated miR‑128‑3p, which indirectly upregulated LIMK1 expression. High FOXD3‑AS1 expression was significantly associated with poor differentiation of tumor tissues, increased tumor size and positive lymph node metastasis. Yes FOXD3‑AS1 overexpression significantly increased CC cell proliferation, migration and invasion compared with the negative control (NC) group, whereas FOXD3‑AS1 knockdown resulted in the opposite effects compared with the small interfering RNA‑NC group. 33760158 FOXD3-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(miR-127-3p/ARF6 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In the present study, we found that the FOXD3-AS1 expression was significantly increased in breast cancer tissues compared with normal tissues and involved in the poor prognosis of patients.Mechanistically, FOXD3-AS1 functioned as a competing endogenous RNA (ceRNA) to upregulate ARF6 expression by targeting miR-127-3p. In addition, the roles of FOXD3-AS1 on cell proliferation and metastasis were achieved through miR-127-3p/ARF6 axis. In the present study, we found that the FOXD3-AS1 expression was significantly increased in breast cancer tissues compared with normal tissues and involved in the poor prognosis of patients. Yes Functionally, knockdown of FOXD3-AS1 suppressed cell proliferation and metastasis abilities in vitro, and tumor growth in vivo. 35678943 FOXD3-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[miR-150/SRCIN1axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU//Transwell Assay FOXD3-AS1 expression was significantly reduced in NSCLC tissues and cell lines, and low expression of FOXD3-AS1 was closely related to positive lymph node metastasis and relatively high tumor grade. FOXD3-AS1 indirectly enhances the expression of SRCIN1 by targeting miR-150, thereby inhibiting NSCLC progression. FOXD3-AS1 expression was significantly reduced in NSCLC tissues and cell lines, and low expression of FOXD3-AS1 was closely related to positive lymph node metastasis and relatively high tumor grade. Yes FOXD3-AS1 over-expression inhibited the proliferation and invasion of H1299 cell lines, while its knockdown promoted the proliferation and invasion of A549 cells. 32924985 FOXD3-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues regulation[miR-127-3p/MED28 axis] qRT-PCR//Western Blot Data mining and analysis of the clinical sample showed that FOXD3-AS1 expression was significantly up-regulated in lung cancer tissues.Our findings provided new evidence that the FOXD3-AS1 regulated NSCLC progression via targeting the miR-127-3p/MED28 axis. Yes In vitro functional assays demonstrated that FOXD3-AS1 overexpression promoted NSCLC cell proliferation and invasion, while FOXD3-AS1 knockdown exerted tumor-suppressive effects on NSCLC cells. 32196603 FOXD3-AS1 LncRNA Homo sapiens Melanoma melanoma cells regulation[miR-127-3p/FJX1 Axis] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay FOXD3-AS1 was markedly upregulated in melanoma cells.Overall, FOXD3-AS1 contributes to the progression of melanoma via miR-127-3p/FJX1 axis. Yes It was validated by loss-of-function assays that cell proliferation and migration were inhibited by FOXD3-AS1 deficiency, while cell apoptosis was facilitated by FOXD3-AS1 knockdown in melanoma. 32354225 FOXD3-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[RICTOR] Wound Healing Assay//CCK8//qRT-PCR//RIP//Transwell Assay FOXD3-AS1 was overexpressed in HCC, and HCC patients with the high level of FOXD3-AS1 had a poor prognosis.The interaction among FOXD3-AS1, miR-335, and RICTOR provides a novel insight for understanding the molecular mechanism of HCC, and FOXD3-AS1, miR-335, and RICTOR can be regarded as the potential targets for HCC treatment. FOXD3-AS1 was overexpressed in HCC, and HCC patients with the high level of FOXD3-AS1 had a poor prognosis. Yes In addition, FOXD3-AS1 knockdown considerably inhibited the proliferation, migration, and invasion of Huh6 cells. 32191537 FOXD3-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC samples and cell lines regulation[miR-296-5p/HMGA1 pathway] qRT-PCR In this research, our group first reported that the levels of FOXD3-AS1 were distinctly elevated in CC samples and cell lines. Moreover, mechanistic studies suggested that FOXD3-AS1 acted as an endogenous sponge by directly binding miR-296-5p, resulting in the suppression of miR-296-5p. The distinct upregulation of FOXD3-AS1 was associated with lymphatic invasion, distant metastasis, and International Federation of Gynecology and Obstetrics stage, and also predicted poor clinical results of CC patients. Yes Functional assays indicated that knockdown of FOXD3-AS1 distinctly suppressed CC progression via affecting cell proliferation, cell apoptosis, and metastasis. 32959937 FOXD3-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues regulation[microRNA-185-3p upregulation] RIP//RNA Pull-Down//Luciferase Report Assay Our findings revealed that lncRNA FOXD3-AS1 and FOXD3 exhibited increased expression levels, while miR-185-3p exhibited diminished levels in NPC.Our findings provide evidence indicating that lncRNA FOXD3-AS1 could bind to miR-185-3p to upregulate the FOXD3 expression, thereby promoting the development of NPC. The levels of lncRNA FOXD3-AS1 and FOXD3 were further correlated with tumor node metastasis stage and pathological type of patients with NPC. Yes In addition, lncRNA FOXD3-AS1 knockdown repressed cell stemness, colony formation, viability, invasion, migration, and in vivo tumor growth, and accelerated cell apoptosis. 33204001 FOXD3-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction(YBX1/H3K27ac) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//ISH//Transfection//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//H&E Staining//Colony Formation Assay//Invasion Assay//ChIP FOXD3-AS1 was highly expressed in NPC tissues and cells. FOXD3-AS1 could specifically bind to YBX1 and have a positive effect on the expression of YBX1. Bioinformatics analysis showed that the promoter of YBX1 had a high enrichment of H3K27ac, which promote mRNA transcription and protein translation of YBX1. Yes Knockdown of FOXD3-AS1 significantly inhibited proliferation, migration, and invasion of NPC cells in vitro and vivo. 34395290 FOXD3-AS1 LncRNA Homo sapiens Glioblastoma GBM cells and tissues Interaction(miR-128-3p/WEE1 ) Western Blot//Transfection//Tunel//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay This study found that FOXD3-AS1 was overexpressed in GBM cells and associated with dismal prognostic outcome in GBM patients. Given that both FOXD3-AS1 and WEE1 contain a binding site for miR-128-3p, FOXD3-AS1 could act as a competing endogenous RNA (ceRNA) to promote WEE1 expression by sponging miR-128-3p. Yes Functional studies revealed that depletion of FOXD3-AS1 inhibited cell growth and induced apoptosis of GBM cells. 35191808 FOXD3-AS1 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues Regulation[TGF-β1/Smads signaling pathway] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that the expression of lncRNA FOXD3-AS1was upregulated and it had negative correlation with the level of miR-296-5p in thyroid cancer tissues and cells. Further study revealed that miR-296-5p was a target of lncRNA FOXD3-AS1 and FOXD3-AS1 exerted anti-tumor effect through up-regulating miR-296-5p. Moreover, we found that FOXD3-AS1 knockdown suppressed the aggressive biological behaviors of thyroid cancer through inactivating the TGF-β1/Smads signaling pathway. Subsequently, the in vivo experiments further verified that the FOXD3-AS1/miR-296-5p axis exerted obvious anti-tumor effect through inhibiting tumor growth and metastasis and the TGF-β1/Smads signaling pathway was also inactivated in vivo by the inhibition of FOXD3-AS1. Yes LncRNA FOXD3-AS1 knockdown effectively suppressed cell proliferation and cell invasion in vitro. 31678422 FEZF1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor specimens Interaction(miR-107/Wnt/β-catenin axis ) Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay The results showed that lncRNA FEZF1-AS1 level was prominently enhanced in HCC tumor specimens and overexpression of FEZF1-AS1 promoted the proliferation, migration and invasion of HCC cells. In mechanism, overexpression of FEZF1-AS1 reduced the expression of miR-107 which inhibited the activation of Wnt/β-catenin signaling. The results showed that lncRNA FEZF1-AS1 level was prominently enhanced in HCC tumor specimens and overexpression of FEZF1-AS1 promoted the proliferation, migration and invasion of HCC cells. Yes Overexpression of β-catenin promoted cell proliferation, migration and invasion which were inhibited by FEZF1-AS1 downregulation. 34023817 FEZF1-AS1 LncRNA Homo sapiens Ovarian Neoplasms cell lines and tissues regulation[miR-130a-5p/SOX4 axis] qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Colony Formation Assay Our data showed overexpression of FEZF1-AS1 in OC cell lines and tissues.In conclusion, our results revealed that FEZF1-AS1 promoted the metastasis and proliferation of OC cells by targeting miR-130a-5p and its downstream SOX4 expression. Yes Cell migration, proliferation, invasion, wound healing and colony formation were suppressed by silencing of FEZF1-AS1. In contrast, cell apoptosis was promoted by FEZF1-AS1 knock-down in vitro. 32135030 HCG11 LncRNA Homo sapiens Pancreatic Carcinoma pancreatic carcinoma samples Interaction(miR-579-3p/MDM2 axis/Notch/Hes1 signaling pathway) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay A significant increase of HCG11 was occurred in pancreatic carcinoma samples. Bioinformatics analysis revealed that HCG11 upregulated MDM2 expression by competitively targeting miR-579-3p. The rescue assays showed that miR-579-3p reversed cell behaviors caused by HCG11, and MDM2 reversed cell properties induced by miR-579-3p. The Notch1 intracellular domain (NICD) and Hes1 protein levels were increased by overexpression of HCG11/MDM2. Our observations highlighted that HCG11 contributed to the progression of pancreatic carcinoma by promoting growth and aggressiveness, and inhibiting apoptosis via miR-579-3p/MDM2/Notch/Hes1 axis. Yes Knockdown of HCG11 suppressed the progression of pancreatic carcinoma cells. 34230221 FALEC LncRNA Homo sapiens Endometrial Neoplasms endometrial cancer tissues,cell lines Expression[highly expressed] qRT-PCR//MTT In our research, FALEC expression was increased in endometrial cancer tissue samples and cell lines compared with corresponding paracancerous normal tissue samples and cell line, respectively. Furthermore, we investigated the clinical significance of FALEC in endometrial cancer patients, and found endometrial cancer patients with advanced clinical stage or large tumor size had higher levels of FALEC expression than those with early clinical stage or small tumor size. Yes The in vitro studies showed silencing of FALEC expression inhibited cell proliferation and arrested cell cycle at G0/G1. In conclusion, FALEC is overexpressed in endometrial cancer tissues and cells, and involved in regulating cell proliferation and cell-cycle. 31387003 F11-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[F11-AS1/miR-211-5p/NR1I3 axis ] RNA Pull-Down//Western Blot//Wound Healing Assay//Tunel//Flow Cytometry//qRT-PCR//CCK8//RIP//FISH//Luciferase Report Assay//Transwell Assay Poor expression of lncRNA F11-AS1 was correlated with poor prognosis in patients with HBV-related HCC, and its down-regulation was caused by the HBx protein. lncRNA F11-AS1 was proved to up-regulate the NR1I3 expression by binding to miR-211-5p. Overexpression of lncRNA F11-AS1 reduced the proliferation, migration and invasion, yet induced apoptosis of HepG2.2.15 cells in vitro, which could be abolished by overexpression of miR-211-5p. Additionally, either lncRNA F11-AS1 overexpression or miR-211-5p inhibition attenuated the tumour growth and metastasis capacity of HepG2.2.15 cells in vivo. Collectively, lncRNA F11-AS1 acted as a modulator of miR-211-5p to positively regulate the expression of NR1I3, and the lncRNA F11-AS1/miR-211-5p/NR1I3 axis participated in HBV-related HCC progression via interference with the cellular physiology of HCC. Yes Overexpression of lncRNA F11-AS1 reduced the proliferation, migration and invasion, yet induced apoptosis of HepG2.2.15 cells in vitro, which could be abolished by overexpression of miR-211-5p. 31880390 F11-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular Regulation[F11-AS1/miR-3146/PTEN axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay To sum up, F11-AS1 suppresses LIHC progression by competitively binding with miR-3146 to regulate PTEN expression. The F11-AS1/miR-3146/PTEN axis is brand new. Yes Thereby, lncRNA F11‐AS1 suppresses LIHC cell proliferation and migration. 31168823 EZR‑AS1 LncRNA Homo sapiens Skin Neoplasms cSCC tissues and cells Interaction(PI3K/AKT signaling pathway) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RIP//Cell Viability Assay//Cell Apoptosis Assay//Invasion Assay//Transwell Assay EZR‑AS1 mRNA expression levels were significantly upregulated in cSCC tissues and cells compared with adjacent healthy tissues and HaCaT cells, respectively. Moreover, EZR‑AS1 knockdown significantly downregulated the protein expression levels of phosphorylated (p)‑PI3K/PI3K and p‑AKT/AKT in cSCC cells compared with the si‑NC group. The PI3K agonist 740Y‑P significantly reversed si‑EZR‑AS1‑mediated effects on SCC13 and SCL‑1 cell proliferation, migration, invasion and apoptosis. Yes Compared with the small interfering RNA (si)‑negative control (NC) group, si‑EZR‑AS1 significantly inhibited SCC13 and SCL‑1 cell proliferation, migration and invasion, but promoted cell apoptosis. By contrast, compared with the pc‑NC group, EZR‑AS1 overexpression significantly enhanced A431 cell proliferation, migration and invasion, but inhibited cell apoptosis. 33236153 EZR-AS1 LncRNA Homo sapiens Colorectal Neoplasms cell lines (HCT8, HCT116, HT29, and SW620 cells) Regulation[TGF-β signaling] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay The expression of lncRNA EZR-AS1 was significantly Expression[Expression[up-expression]-expression]-regulated in CRC cell lines (HCT8, HCT116, HT29, and SW620 cells), which was significantly different from that of normal human fetal colonic mucosa cells (FHC cells) (P<0.01). Silencing of lncRNA EZR-AS1 significantly Expression[down-expression]-regulated TGF-β, Smad2, and α-SMA expression in HCT116 and HT29 cells at the protein level (P<0.05). The intervention of SB431542 (a TGF-β receptor blocker) and silencing of Smad2 both significantly Expression[down-expression]-regulated lncRNA EZR-AS1 expression in HCT116 and HT29 cells (P<0.01). Yes HCT116 and HT29 cells were then transfected with EZR-AS1 shRNA (sh-EZR-AS1) to silence lncRNA EZR-AS1 (P<0.01). When compared with the Control, after transfection of SH-EZR-AS1, E-cadherin was Expression[Expression[up-expression]-expression]-regulated, Vimentin was Expression[down-expression]-regulated, the apoptosis rate was increased, the cell viability, wound healing rate, and the number of invasive cells were decreased in HCT116 and HT29 cells (P<0.05). Silencing of lncRNA EZR-AS also significantly reduced the tumor volume and weight in mice injected with sh-EZR-AS1-transfected HCT116 and HT29 cells (P<0.05). 31693738 EZR-AS1 LncRNA Homo sapiens Skin Neoplasms cSCC tissue and cells regulation[PI3K/AKT signaling pathway] Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Transwell Assay EZR?AS1 mRNA expression levels were significantly upregulated in cSCC tissues and cells compared with adjacent healthy tissues and HaCaT cells, respectively. In conclusion, the present study demonstrated that si‑EZR‑AS1 inhibited cSCC cell proliferation, migration and invasion, and promoted cell apoptosis, potentially via regulating the PI3K/AKT signaling pathway. Therefore, the present study provided novel insights into the diagnosis and treatment of cSCC. Yes Compared with the small interfering RNA (si)?negative control (NC) group, si?EZR?AS1 significantly inhibited SCC13 and SCL?1 cell proliferation, migration and invasion, but promoted cell apoptosis. By contrast, compared with the pc?NC group, EZR?AS1 overexpression significantly enhanced A431 cell proliferation, migration and invasion, but inhibited cell apoptosis. 33236153 EZR-AS1 LncRNA Homo sapiens Coronary Disease blood regulation[SMYD3] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The findings revealed that lncRNA EZR-AS1 was highly expressed in the peripheral blood of patients with CHD.Collectively, these results demonstrate that lncRNA EZR-AS1 plays an important role in HUVECs function via SMYD3 signaling. Yes In vitro experiments showed that the overexpression of EZR-AS1 could enhance proliferation, migration, and apoptosis by upregulating the expression of EZR in HUVECs; downregulation of lncRNA EZR-AS1 resulted in the opposite effect. 32596350 EXOSC2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cancer tissues and cells lines Regulation[Erk1/2 signaling,STAT1 pathway] CCK8//qRT-PCR//Colony Formation Assay The expression level of lincRNA P7 was significantly aberrantly deceased in HCC cancer tissues and cells lines.Mechanistically, lincRNA P7 blocked Erk1/2 signaling and repressed activation of the STAT1 pathway. Yes Gain- and loss-of-function experiments revealed that overexpression of lincRNA P7 significantly inhibited the proliferation of HCC-derived cancer cells, whereas lincRNA P7 knockdown promoted cell growth. 30546827 EWSAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-326/FBXL20 pathway) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//IHC//Transwell Assay We found that EWSAT1 was highly expressed in CRC tissues and cell lines and associated with poor overall survival. Moreover, miR-326 was found to be a target of EWSAT1, and miR-326 inhibitor could partially reverse the effects on CRC cell progression induced by si-EWSAT1. Subsequently, we validated FBXL20 as a vital downstream target for miR-326, and EWSAT1 positively regulated FBXL20 via miR-326 in vitro. We found that EWSAT1 was highly expressed in CRC tissues and cell lines and associated with poor overall survival. Yes In vitro, knockdown of EWSAT1 suppressed the cell proliferation, migration and invasion. 33469313 EWSAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Regulation( Hippo-YAP signaling) qRT-PCR The results indicated that EWSAT1 was upregulated significantly in HCC relative to that in normal tissues and was correlated with an aggressive phenotype and low patient survival. Mechanistically, EWSAT1 binds directly to Yes-associated protein (YAP), promotes Sarcoma gene (Src)-induced phosphorylation of YAP, facilitates nuclear translocation of YAP, and consequently, activates the transcription of Hippo-YAP signaling target genes involved in cancer evolution. Yes Functional experiments demonstrated that EWSAT1 could promote proliferation and HCC cell metastasis both in vitro and in vivo. 36421017 EWSAT1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues regulation[miR-330-5p] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In cervical cancer, the expression of EWSAT1 was enhanced and contributed to the poor prognosis.Our study revealed that EWSAT1 enhances CPEB4 expression through sponging miR-330-5p, thereby promoting cervical cancer development, which might provide potential therapeutic targets for clinically cervical cancer patients. In cervical cancer, the expression of EWSAT1 was enhanced and contributed to the poor prognosis. Yes Downregulated EWSAT1 expression inhibited Hela cell migration, proliferation, and invasion. 32556917 EWSAT1 LncRNA Homo sapiens Glioma interaction[sponging miR-152-3p] CCK8//Transwell Assay Increased EWSAT1 was associated with the presence of necrosis on magnetic resonance imaging scans in patients with glioma. The present study demonstrated that EWSAT1 interacted directly with miR-152-3p, and rescue experiments confirmed that EWSAT1 participated in glioma development by suppressing miR-152-3p. Yes Furthermore, knockdown of EWSAT1 was indicated to suppress the proliferative and invasive abilities of glioblastoma cell lines using Cell Counting Kit-8 and Transwell assays. 32724428 ET-20 LncRNA Homo sapiens Breast Neoplasms breast cancer cells Regulation Invasion Assay//Migration Assay//qRT-PCR//FISH//RNA-seq//IP//Transwell Assay//Bioinformatics Analysis//IF Both ET-20 and Tnc are regulated by the EMT master transcription factor Sox4. Notably, ablation of ET-20 lncRNA effectively blocks Tnc expression and with it EMT. Mechanistically, ET-20 interacts with desmosomal proteins, thereby impairing epithelial desmosomes and promoting EMT. Yes Notably, ablation of ET-20 lncRNA effectively blocks Tnc expression and with it EMT. 34633031 ERLR LncRNA Homo sapiens Vitreoretinopathy, Proliferative RPE cells Interaction(TCF4/MYH9 ) RNA Pull-Down//ChIP//Western Blot//Migration Assay//FISH//qRT-PCR//Microarray//Transwell Assay//IF In this study, we found that ERLR is upregulated in RPE cells stimulated with transforming growth factor (TGF)-β1 as detected by lncRNA microarray and RT-PCR. Mechanistically, chromatin immunoprecipitation (ChIP) assays indicated that the transcription factor TCF4 directly binds to the promoter region of ERLR and promotes its transcription. ERLR mediates EMT by directly binding to MYH9 protein and increasing its stability. TCF4 and MYH9 also mediate TGF-β1-induced EMT in RPE cells. Yes In vitro, silencing ERLR in RPE cells attenuated TGF-β1-induced EMT, whereas overexpressing ERLR directly triggered EMT in RPE cells. In vivo, inhibiting ERLR in RPE cells reduced the ability of cells to induce experimental PVR. 33664479 ERLNC1 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues Interaction[downregulating KiSS1] qRT-PCR We found that TC0101441 levels were elevated in EOC tissues compared with those in normal controls and significantly correlated with an advanced clinical stage and lymph node metastasis.Furthermore, loss-of-function assays showed that TC0101441 promoted the invasive and metastatic capacities of EOC cells both in vitro and in vivo TC0101441 was determined to be an independent prognostic predictor of overall survival (OS) and disease-free survival (DFS). Yes Furthermore, loss-of-function assays showed that TC0101441 promoted the invasive and metastatic capacities of EOC cells both in vitro and in vivo 31577838 ERBIN CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines and tissues Interaction(miR-1263/CDK6 Axis) colony Formation Assay//Western Blot//ISH//Transfection//Flow Cytometry//qRT-PCR//FISH//PCR//Colony Formation Assay//IF The expression of circERBIN was upregulated in HCC cell lines and tissues, which was predictive of a poor prognosis in HCC patients. Mechanistic investigations revealed that circERBIN regulated HCC proliferation by acting as a sponge of miR-1263, which subsequently targeted cyclin dependent kinase 6 and controlled G1/S transition. The expression of circERBIN was upregulated in HCC cell lines and tissues, which was predictive of a poor prognosis in HCC patients. Yes Elevated circERBIN promoted G1/S transition of HCC cells, thus facilitating the proliferation and tumorigenesis of HCC cells. 35530358 Erbb4-IR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction[downregulating miR-145] qRT-PCR It was observed that Erbb4-IR was upregulated in tumor tissues of patients with ESCC.In addition, miR-145 overexpression attenuated the effects of Erbb4-IR overexpression. Therefore, lncRNA Erbb4-IR may promote ESCC by downregulating miR-145. Yes Erbb4-IR overexpression led to downregulated miR-145, and increased rates of ECSS cell proliferation and decreased rates of ECSS cell apoptosis. 31119810 Erbb4-IR LncRNA Homo sapiens prostate carcinoma prostate carcinoma tissues regulation[ downregulating miR-21] CCK8//qRT-PCR//Cell Apoptosis Assay The results revealed that Erbb4-IR was downregulated in prostate carcinoma tissues compared with adjacent non-cancerous tissues, and that low expression of Erbb4-IR in tumor tissues was closely associated with poor survival.Therefore, the results of the present study suggested that lncRNA Erbb4-IR is downregulated in prostate carcinoma and may inhibit cancer development by downregulating miR-21. The results revealed that Erbb4-IR was downregulated in prostate carcinoma tissues compared with adjacent non-cancerous tissues, and that low expression of Erbb4-IR in tumor tissues was closely associated with poor survival. Yes Moreover, Erbb4-IR overexpression increased apoptosis and inhibited the proliferation of prostate carcinoma cells. 32269615 ERBB2 CircRNA Homo sapiens Asthma ASMCs Interaction(miR-98-5p/IGF1R) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//ELISA CircERBB2 was identified to directly interact with miR-98-5p, and overexpression of miR-98-5p abolished the function of circERBB2 on PDGF-BB-stimulated ASMCs. IGF1R was identified as a target of miR-98-5p, and knockdown of IGF1R relieved the PDGF-BB-induced ASMCs proliferation and migration. Yes The depletion of circERBB2 attenuated the proliferation, migration, and levels of inflammatory factors induced by PDGF-BB and cell apoptosis. 34616159 EPS15-AS1 LncRNA Homo sapiens Liver Neoplasms liver cancer stem cells and tissues Interaction(EPS15) Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay//cell invasion assay EPS15 was highly expressed in LCSCs, while lncRNA EPS15-AS1 was lowly expressed in LCSCs (P<0.05). However, simultaneous overexpression of lncRNA EPS15-AS1 and EPS15 attenuated the effect of lncRNA EPS15-AS1 overexpression alone on proliferation and apoptosis of LCSCs. Yes After silencing lncRNA EPS15-AS1, the proliferation, invasion, and EPS15 protein expression of LCSCs were promoted (P<0.05) while apoptosis was suppressed (P<0.05). After overexpression of lncRNA EPS15-AS1, the proliferation, invasion, and EPS15 protein expression of LCSCs were suppressed while the apoptosis ability was promoted. 36398248 FALEC LncRNA Homo sapiens tongue squamous cell carcinoma Interaction[ECM1 ] RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Microarray//Colony Formation Assay//EdU Staining//Transwell Assay The focally amplified long non-coding RNA in epithelial cancer (FALEC) was found downregulated in the tissues of tongue squamous cell carcinoma (TSCC) and was predicted to present a good prognosis by bioinformatics analysis. RNA pull-down and RNA immunoprecipitation demonstrated that FALEC could recruit enhancer of zeste homolog 2 (EZH2) at the promoter regions of extracellular matrix protein 1 (ECM1), epigenetically repressing ECM1 expression. The data revealed that FALEC acted as a tumor suppressor in TSCC and may aid in developing a novel potential therapeutic strategy against TSCC. Yes Experiments indicated that FALEC knockdown significantly increased the proliferation and migration of TSCC cells both in vitro and in vivo; however, FALEC overexpression repressed these malignant behaviors. 31335317 FALEC LncRNA Homo sapiens Uterine Cervical Neoplasms blood Expression[highly expressed] qRT-PCR FALEC was significantly up-regulated in the blood plasma from cervical cancer patients and had significant correlation with tumor size, the FIGO stage, and lymph node metastasis. FALEC was significantly up-regulated in the blood plasma from cervical cancer patients and had significant correlation with tumor size, the FIGO stage, and lymph node metastasis. Yes FALEC overexpression could stimulate proliferation and invasion of Hela cells. 31248657 EPIST LncRNA Homo sapiens Carcinoma, Hepatocellular CSCs Interaction(microRNA-127-3p/DUSP1/ERK axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay C5orf66-AS1 was found as the most upregulated long noncoding RNAs (lncRNAs) in CSCs after Exo treatment. The integrated bioinformatic analyses and luciferase assays suggested that C5orf66-AS1 upregulated DUSP1 expression through sequestering microRNA-127-3p (miR-127-3p).DUSP1 inhibition increased the phosphorylation of ERK. To conclude, this research reported that MSC-derived Exo block malignant behaviors of HCC-sourced CSCs through a C5orf66-AS1/miR-127-3p/DUSP1/ERK axis. Yes Either artificial overexpression of miR-127-3p or silencing of DUSP1 blocked the inhibitory functions of Exo in the CSCs. Similar results were reproduced in vivo where Exo reduced the growth of xenograft formed by CSCs in nude mice, and this reduction was blocked upon miR-127-3p overexpression or DUSP1 silencing. 34431063 FALEC LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction[microRNA-761/CRKL pathway] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot LncRNA FAL1 was highly expressed in OSCC tissues and cell lines.The mRNA expression of microRNA-761 was lowly expressed in OSCC tissues and cell lines. Dual-Luciferase reporter gene assay showed that lncRNA FAL1 directly bound to microRNA-761. Meanwhile, microRNA-761 expression was negatively regulated by FAL1. CRKL was verified as the target gene of microRNA-761. Both the mRNA and protein levels of CRKL were remarkably upregulated in OSCC tissues and cell lines. CRKL expression was found to be negatively regulated by microRNA-761 in OSCC cells. Lowly expressed microRNA-761 reversed the inhibitory effect of lncRNA FAL1 knockdown on the proliferative potential of OSCC cells. In addition, the overexpression of CRKL reversed the inhibitory effect of lncRNA FAL1 down-regulation on the proliferative potential of OSCC cells as well. Yes The proliferative capacity of OSCC cells was significantly inhibited by lncRNA FAL1 knockdown. 31298329 FAM225A LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues regulation[NETO2 and FOXP1 ] Western Blot//Wound Healing Assay//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We discovered that FAM225A exhibited higher expression in ESCC. Our results suggested that FAM225A upregulated NETO2 and FOXP1 expression by sponging miR-206 to accelerate ESCC progression and angiogenesis. Yes The silence of FAM225A attenuated cell viability, migration, and invasion, but facilitated cell apoptosis in ESCC. 33006432 FAM225A LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma Interaction(miR-197-5p/NONO ) In Vivo Experiment//Western Blot//ISH//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay We confirmed that upregulation of FAM225A in ESCC and overexpression of FAM225A was associated with poor outcome in ESCC patients using TCGA ESCC cohort.In summary, our findings suggest that lncRNA FAM225A promotes ESCC development and progression via sponging miR-197-5p and upregulating NONO expression. We confirmed that upregulation of FAM225A in ESCC and overexpression of FAM225A was associated with poor outcome in ESCC patients using TCGA ESCC cohort. Yes Knockdown of FAM225A significantly inhibited cell growth, migration and invasion of ESCC cells in vitro and inhibited ESCC xenograft development in vivo. 33442405 FAM225A LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Interaction[Sponge miR-590-3p/miR-1275 and Upregulate ITGB3] Other Here, based on a microarray analysis, we identified 384 dysregulated lncRNAs, of which, FAM225A was one of the most upregulated lncRNAs in NPC. Mechanistically, FAM225A functioned as a competing endogenous RNA (ceRNA) for sponging miR-590-3p and miR-1275, leading to the upregulation of their target integrin β3 (ITGB3), and the activation of FAK/PI3K/Akt signaling to promote NPC cell proliferation and invasion. In summary, our study reveals a potential ceRNA regulatory pathway in which FAM225A modulates ITGB3 expression by binding to miR-590-3p and miR-1275, ultimately promoting tumorigenesis and metastasis in NPC. Yes FAM225A functioned as an oncogenic lncRNA that promoted NPC cell proliferation, migration, invasion, tumor growth, and metastasis. 31331909 FAM225A LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction(FUS/CENP-N ) RNA Pull-Down//Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//RIP//Invasion Assay FAM225A and CENP-N expression levels were evaluated in NPC tissues and cell lines. FAM225A stabilized CENP-N mRNA by recruiting FUS. FAM225A activated cGAS-STING by regulating the expression of CENP-N to promote NPC cell proliferation, migration and EMT. Yes FAM225A knockdown inhibited NPC cell proliferation, migration and EMT. 35809496 FAM222A-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tumor samples and cell lines Interaction( miR-let-7f/MYH9 axis) RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay The expression of FAM222A-AS1 is significantly upregulated in CRC tumor samples and cell lines. Furthermore, FAM222A-AS1 was mainly distributed in the cytoplasm. It may directly bound to miR-let-7f and inhibit its expression and upregulate MYH9. In summary, FAM222A-AS1, as a novel oncogene in CRC, may promote the CRC progression by inhibiting miR-let-7f/MYH9 axis. The FAM222A-AS1/miR-let-7f/MYH9 signaling pathway may be a novel valuable target for inhibiting CRC. CRC patients with elevated FAM222A-AS1 expression in the tumor samples had unfavorable overall survival and disease-free survival. Yes CRC patients with elevated FAM222A-AS1 expression in the tumor samples had unfavorable overall survival and disease-free survival. 35646686 FAM207BP LncRNA Homo sapiens Adenocarcinoma of Lung The tumor tissues and matched normal tissue specimens from 41 cases of LUAD patients Expression [highly expressed] Transfection//Wound Healing Assay//CCK8//qRT-PCR//Survival Analysis//RNA-seq//Transwell Assay FAM207BP expression was distinctly higher in LUAD than normal tissues. RT-qPCR results confirmed that FAM207BP was significantly highly expressed in LUAD tissues and cells. Patients with its high expression indicated worse OS and DFS time. Yes  Knockdown of FAM207BP distinctly suppressed cellular viability, migration and invasion for LUAD cells. Also, its expression was negatively related to B cell infiltration levels.  33434533 FAM201A LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues Interaction[regulating ABCE1 expression ] CCK8//qRT-PCR//Western Blot//Transwell Assay High levels of FAM201A expression were more likely to present in patients with squamous type, M1 stage, and inferior overall survival.FAM201A may markedly induce migration and invasion of LSCC, resulting in the M1 stage and poor survival. These findings suggest the FAM201A-ABCE1 axis as a novel therapeutic target in LSCC. Yes FAM201A knockdown inhibits cell proliferation, migration, and invasion of LSCC cells in vitro, and represses tumor growth in vivo. 31841188 FAM201A LncRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(miR-3163/MACC1 axis) RNA Pull-Down//Western Blot//qRT-PCR//RIP//IHC FAM201A expression level was significantly enhanced in CRC cells compared with normal cells. By exploring molecular mechanism of FAM201A, we found that FAM201A acted as a sponge of miR-3163. More importantly, oncogene MACC1 was confirmed to be a direct target of miR-3163 and FAM201A modulated MACC1 expression level via competing for miR-3163. Subsequently, we testified that FAM201A exerted its role in the tumorigenesis and development of CRC through targeting miR-3163/MACC1. Yes Further, functional experiments illustrated that knockdown of FAM201A restrained cell growth, stemness and promoted chemoresistance of CRC cells. Animal assay certified that FAM201A expedited CRC cell growth in vivo. 36067543 FAM201A LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells regulation[miR-186-5p/TNKS1BP1 axis] ChIP//Wound Healing Assay//RIP//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay The results showed that FAM201A expression was significantly upregulated in TNBC tissues and cells. Collectively, our study revealed that TCF3-activated FAM201A promoted aggressive phenotypes of TNBC cells by upregulating TNKS1BP1 expression. Yes Functionally, FAM201A knockdown inhibited TNBC cell proliferation, migration and invasion, and accelerated cell apoptosis. 33011533 FAM181A-AS1 LncRNA Homo sapiens Glioma cell lines regulation[sponging miR-129-5p and upregulating ZRANB2] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining FAM181A-AS1 expression is higher in glioma cell lines compared to normal human astrocytes (NHA). These findings show that FAM181A-AS1 promotes gliomagenesis by enhancing ZRANB2 expression by sponging of miR-129-5p. Yes CCK-8, EdU, and colony formation assays show that FAM181A-AS1 knockdown decreases proliferation and colony formation in glioma cells, whereas, FAM181A-AS1 overexpression reverses these effects. 33080570 FAM13A-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Interaction(miRNA-205-3p/DDI2 Axis) In Vivo Experiment//Western Blot//ISH//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//IHC//Invasion Assay//Transwell Assay . Low FAM13A-AS1 expression and high miRNA-205-3p expression were observed in cervical cancer tissues and cell lines (SiHa and HeLa). In addition, FAM13A-AS1 negatively regulated the expression of miRNA-205-3p, while miRNA-205-3p reduced DDI2 expression, and miRNA-205-3p mimic reversed the effects of FAM13A-AS1 overexpression in vitro. Yes Upregulating the expression of FAM13A-AS1 inhibited proliferation, migration, and invasion of SiHa and HeLa cells, while the apoptosis of SiHa and HeLa cells was increased. More importantly, LV-FAM13A-AS1 could improve tumor development in vivo. 35783157 FAM13A-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell 539 RCC patients Interaction(miR-141-3p) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//FISH//MTT//Luciferase Report Assay//Cell Cycle Assay//Invasion Assay By analyzing the gene expression profiles of 539 RCC patients from the TCGA cohort and 40 RCC patients from an independent cohort, we identified FAM13A-AS1, a poorly studied lncRNA, upregulated in RCC patients. FAM13A-AS1 regulates the expression of NEK6 by decoying miR-141-3p. Yes Knockdown experiments revealed that FAM13A-AS1 promotes cell proliferation, migration, and invasion by interacting with miR-141-3p. 35402517 FAM138B LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells and tissues Interaction(miR-105-5p) CCK8//qRT-PCR The expression of FAM138B is down-regulated in NSCLC cells and tissues. FAM138B targets miR-105-5p, and there is a negative correlation between FAM138B and miR-105-5p. It is confirmed that FAM138B inhibits the progression of NSCLC by targeting miR-105-5p and can be a potential prognostic biomarker for NSCLC. Yes Overexpression of FAM138B can inhibit the expression level of miR-105-5p in NSCLC cells, and the ability of NSCLC cells to proliferate, migrate and invade is downregulated. 36529892 FALEC LncRNA Homo sapiens Stomach Neoplasms Gastric Cancer tissues Interaction[ECM1 ] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay Mechanistic investigations demonstrated that small interfering RNA-induced silencing of FALEC decreased expression of the nearby gene extracellular matrix protein 1 (ECM1) in cis. Additionally, ECM1 and FALEC expression were positively correlated, and high levels of ECM1 predicted shorter survival time in GC patients. Our results suggest that the downregulation of FALEC significantly inhibited the migration and invasion of GC cells through impairing ECM1 expression by exerting an enhancer-like function. Our work provides valuable information and a novel promising target for developing new therapeutic strategies in GC. Yes Further experiments revealed that FALEC knockdown significantly inhibited GC cells migration and invasion in vitro. 30984243 FALEC LncRNA Homo sapiens Stomach Neoplasms GC cells Regulation(miR-203b/PIM3 axis) Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Invasion Assay The results showed that FALEC and PIM3 were highly expressed, while miR-203b was lowly expressed, in GC. FALEC knockdown repressed GC cell proliferation, migration, and invasion, and promoted apoptosis and autophagy in vitro. Meanwhile, FALEC knockdown prevented growth and induced GC autophagy in vivo. This shows that FALEC upregulated PIM3 by sponging miR-203b in GC cells. Besides, FALEC induced the malignant behaviors of GC cells by regulating the miR-203b/PIM3 axis. Yes FALEC knockdown repressed GC cell proliferation, migration, and invasion, and promoted apoptosis and autophagy in vitro. 35722357 FALEC LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction[miR-637/NUPR1 pathway] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Here our results demonstrate that lncRNA FAL1 is markedly upregulated in CRC tissues and cells Moreover, we demonstrate that lncRNA FAL1 promotes carcinogenesis of CRC cells via regulation of the miR-637/NUPR1 pathway. Yes Here our results demonstrate that lncRNA FAL1 is markedly upregulated in CRC tissues and cells, and lncRNA FAL1 promotes proliferation ability, migration and invasion in CRC cells. 30267804 FALEC LncRNA Homo sapiens Colorectal Neoplasms cell lines regulation[regulating miR-2116-3p-targeted PIWIL1] Wound Healing Assay//Flow Cytometry//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay FALEC was aberrantly up-regulated in CRC.Our study revealed that FALEC promoted CRC progression via restoring the expression of miR-2116-3p-targeted PIWIL1, suggesting the potential application of targeting FALEC in the treatment of CRC. Yes FALEC knockdown could impair CRC cell proliferation, migration and invasion, whereas facilitate cell apoptosis. 33073675 FALEC LncRNA Homo sapiens Colonic Neoplasms colon tumor tissues Expression[highly expressed] qRT-PCR Here, our results indicate that FAL1 expression was remarkably up-regulated in colon tumor tissues as compared to corresponding tumor-adjacent normal tissues. Importantly, the cumulative survival rate of patients with high levels of FAL1 in tumor tissues was considerably lower than those with low FAL1 levels in tumor tissues. Cox regression analysis showed that lncRNA FAL1 could act as an independent prognostic factor in CRC. Yes Knockdown of FAL1 in HT29 cells attenuated cell proliferation and stimulated cell apoptosis. 30290064 FALEC LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues regulation[Wnt/β-catenin signaling pathway] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The expression level of FALEC was significantly higher in PTC tissues than that of adjacent normal tissues.FALEC expression was up-regulated in PTC tissues and cell lines. Highly expressed FALEC facilitated the proliferation, migration, and invasion of PTC by regulating the Wnt/β-catenin signaling pathway. Yes CCK-8 assay revealed that the proliferation ability of PTC cells was remarkably weakened after down-regulation of FALEC in vitro. Wound healing and transwell assays demonstrated that, compared with si-normal control (NC) group, the migration and invasion capabilities declined significantly in si-FALEC group. 32373973 EPIST LncRNA Homo sapiens Stomach Neoplasms GC tissues, serum, and cell lines Expression[lower expressed] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay C5orf66-AS1 expression was downregulated in GC cells compared to that in adjacent normal tissues.Serum C5orf66-AS1 levels were significantly lower in GC patients than in superficial gastritis (GS) and atrophic gastritis (GA) patients. Yes Additionally, in vitro overexpression of C5orf66-AS1 in AGS cells inhibited cell proliferation, migration, and invasion. 32308414 EPIST LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-149-5p) CCK8//qRT-PCR The results demonstrated that C5orf66-AS1 was significantly upregulated and miR-149-5p was significantly downregulated in OS tissues and cells (MG63 and U2OS). Bioinformatics analysis further confirmed that miR-149-5p could directly bind to C5orf66-AS1. Yes In addition, C5orf66-AS1 silencing significantly inhibited the proliferation, invasion and migration of U2OS cells, and stimulated cell apoptosis. These findings were reversed using miR-149-5p inhibitor.Increased Bax expression and decreased Bcl-2 and MMP-9 expression were also observed in C5orf66-AS1-siRNA transfected U2OS cells, compared with the control group. 34539861 FEZF1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Interaction[targeting miR-196a] CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining The results of qRT-PCR proved that the expression level of FEZF1-AS1 in OSCC tissues was significantly higher than that of para-carcinoma tissues, and the difference was statistically significant. Therefore, it was believed that FEZF1-AS1 might promote the malignant progression of OSCC by regulating miR-196a. The pathological stage was significantly higher in patients with high-expression FEZF1-AS1 than those with low-expression FEZF1-AS1, while the overall survival rate was remarkably lower. Yes The proliferation ability of cells in FEZF1-AS1 silencing group declined significantly when compared with the NC group. 31378890 EOLA1-DT LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Interaction(miR-146b-3p/PRSS8) qRT-PCR//Wound Healing Assay//MTT//Western Blot LINC00893 and PRSS8 were significantly downregulated, while miR-146b-3p was upregulated in colon cancer tissues compared to control group. Overexpressed LINC00893 or silenced miR-146b-3p suppressed the proliferation, migration, and invasion while promoting apoptosis in colon cancer cells (HCT116, SW620). Moreover, miR-146b-3p overexpression reversed the inhibitory effect of LINC00893, while PRSS8 knockdown rescued the suppressive effect of miR-146b-3p inhibitor on malignant cell behaviors in colon cancer. Furthermore, the tumor growth in mice was significantly reduced by LINC00893 overexpression. Yes Overexpressed LINC00893 or silenced miR-146b-3p suppressed the proliferation, migration, and invasion while promoting apoptosis in colon cancer cells (HCT116, SW620). Moreover, miR-146b-3p overexpression reversed the inhibitory effect of LINC00893, while PRSS8 knockdown rescued the suppressive effect of miR-146b-3p inhibitor on malignant cell behaviors in colon cancer. Furthermore, the tumor growth in mice was significantly reduced by LINC00893 overexpression. 35571488 ENTPD3-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues Interaction(miR-155/HIF-1α signaling) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Flow Cytometry//RIP//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay The results showed that the G > A mutation of rs67311347 created a binding motif of ZNF8 and subsequently upregulated ENTPD3-AS1 expression by acting as an enhancer. Furthermore, ENTPD3-AS1 interacted with miR-155-5p and activated the expression of HIF-1α, which was an important tumor suppressor gene in the development of RCC. The TCGA-KIRC and our cohorts both confirmed the downregulation of ENTPD3-AS1 in RCC tissues and demonstrated that increased ENTPD3-AS1 expression was associated with good OS and PFS. Yes The functional experiments revealed that overexpression of ENTPD3-AS1 inhibited cell proliferation in RCC cell lines and the effect could be rescued by knocking down HIF-1α. 34218253 ENST00000623984 LncRNA Homo sapiens Colonic Neoplasms colorectal cancer tissues and cell lines Expression(highly expressed) qRT-PCR The ENST000000623984 expression level was increased in colorectal cancer. Yes Knockdown of ENST000000623984 reduced cell viability, proliferation rate, cell migration and invasion. 34247468 ENST00000607393 LncRNA Homo sapiens Glaucoma, Open-Angle Aqueous humor Expression[highly expressed] qPCR//Microarray ENST00000607393 was also significantly higher in the iris and plasma of POAG patients. Yes Last, ENST00000607393 knockdown alleviated calcification of primary human trabecular meshwork cells in vitro. 30677397 ENST00000606790.1 LncRNA Homo sapiens Thyroid Cancer, Papillary NPTC tissues or cell lines regulation[ PI3K/AKT Pathway] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay ENST was significantly up-regulated in PTC tissues or PTC cell lines (PTC and IHH4 cell lines), compared to NPTC tissues or normal cell lines, respectively.Overall, our results demonstrated that ENST can promote PTC progression by activating the PI3K/AKT signaling pathway, suggesting that ENST can serve as a potential biomarker and new therapeutic target for patients with PTC. High expression of ENST was strongly correlated to lymph node metastasis and tumor size at diagnosis. Yes Silencing of ENST significantly inhibited cell growth and colony formation, arrested the cell cycle at G2/M phase, upregulated the expression of CHK1, downregulated the expression of CDC25C, and inhibited cell invasion. 32791924 ENST00000547547 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] ISH//qRT-PCR//MTT//Transwell Assay In the present study, we demonstrated that the ENST00000547547 level is significantly downregulated in CRC tissues compared to normal tissues. Yes . Furthermore, the overexpression of ENST00000547547 inhibited the cell proliferation, invasion and migration of CRC cells in vitro and decreased tumorigenesis ability in vivo. Furthermore, we provided the first evidence that ENST00000547547 inhibited the proliferation of CRC cells by affecting the cell cycle and apoptosis. 30542703 ENST00000543604 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miRNA 564/AEG-1 or ZNF326/EMT ) CCK8//qRT-PCR//RNA Pull-Down//Western Blot In this study, we found that the expression levels of lncRNA 604 were increased in CRC. LncRNA 604 could predict the prognosis of CRC and was an independent negative factor. LncRNA 604 exerted a synergistic effect with miRNA 564 or ZNF326 on the prognosis of CRC. LncRNA 604 could improve chemoresistance by increasing the expression of AEG-1, NF-κB, and ERCC1. Yes LncRNA 604 could promote CRC cell proliferation and metastasis through the miRNA 564/AEG-1 or ZNF326/EMT signaling axis in vivo and in vitro. 36081570 ENST00000538705.1 LncRNA Homo sapiens Acute Coronary Syndrome ACS patients, myocardial infarction rats Interaction(ALOX15) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Microarray Coexpression analysis indicated the interaction between ENST00000538705.1 and ALOX15. RT-qPCR confirmed the remarkable upregulation of circulating ENST00000538705.1 and ALOX15 in ACS patients. In HCAECs, ENST00000538705.1 knockdown lowered the expression of ALOX15 but ALOX15 did not alter the expression of ENST00000538705.1. Yes Silencing ENST00000538705.1 or ALOX15 weakened the proliferation and migration of HCAECs. Additionally, knockdown of ENST00000538705.1 or ALOX15 relieved myocardial damage, decreased serum TC and LDL levels, and elevated HDL levels in myocardial infarction rats. 35571613 ENST00000455974 LncRNA Homo sapiens Colonic Neoplasms colon tissues Regulated[up-regulated] qRT-PCR Here, firstly, we observed that ENST00000455974 was gradual increased across colon normal-adenoma-carcinoma-metastasis sequence by quantitative real-time PCR.Mechanistically, ENST00000455974 was mainly located in the nucleus of colon cancer cells and it promoted the growth and metastasis of pMMR CC cells through up-regulating JAG2. Thirdly, a higher level of ENST00000455974 was associated with a poorer patient survival. Yes Furthermore, Knockdown of ENST00000455974 led to reduced proliferation and migration of colon cancer cells. 30473216 ENST00000430471 LncRNA Homo sapiens Colorectal Neoplasms regulation[Regulating the Expression of YBX-1] qRT-PCR//Wound Healing Assay//RNA Pull-Down Silencing of ENST00000430471 inhibits proliferation, migration, and invasion of CRC cells by regulating YBX-1 expression. Yes Silencing of ENST00000430471 inhibits proliferation, migration, and invasion of CRC cells by regulating YBX-1 expression. 32848471 ENST00000413528 LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[miR-593-5p/PLK1 pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining Expression of ENST00000413528 was significantly increased in glioma tissues and LN229 and U251 cells.lncRNA ENST00000413528 is closely related to the development of glioma via the miR-593-5p/PLK1 pathway. Yes Knockdown of ENST00000413528 in glioma cells inhibited cell proliferation and colony formation abilities, induced the G0/G1 arrest of the cell cycle, and promoted apoptosis. 30924320 ENSG00000231881 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Regulation[VEGFC signaling pathway] Western Blot//Tube Formation Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay ENSG00000231881 expression level was substantially higher in colorectal cancer tissues than in paracancerous tissues and correlated with malignancy and prognosis.ENSG00000231881 could bind to miR-133b and consequently affect the cell functions through the regulation of VEGFC expression via miR-133b. Yes In colorectal cancer cells, ENSG00000231881 overexpression significantly promoted cell proliferation, metastasis, and tube formation in lymphatic epithelium, decreased miR-133b expression, and increased VEGFC expression. On the contrary, ENSG00000231881 interference expression showed exactly opposite results. 30581003 ENO1 CircRNA Homo sapiens Adenocarcinoma of Lung cell lines Regulation[miR-22-3p/ENO1 axis] TUNEL//Western Blot//ISH//Wound Healing Assay//Tunel//qRT-PCR//RIP//FISH//PCR//IP//IHC//IF Circ-ENO1 and its host gene ENO1 were identified to be upregulated in LUAD cells.In summary, current study elucidated that circ-ENO1 promoted glycolysis and tumor progression in LUAD by miR-22-3p/ENO1 axis, indicating circ-ENO1 as a promising treatment target for LUAD patients. Yes Functionally, silencing circ-ENO1 retarded glycolysis, inhibited proliferation, migration and EMT, induced apoptosis. 31767835 EMX2OS LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues regulation[miR-654-3p/AKT3/PD-L1 Axis] qRT-PCR//Luciferase Report Assay EMX2OS is overexpressed in human ovarian cancer tissues. These results demonstrated that the EMX2OS/miR-654/AKT3/PD-L1 axis confers aggressiveness in ovarian cancer and may represent a therapeutic target for OC metastasis. Yes Knockdown of EMX2OS reduced, while overexpression of EMX2OS enhanced the proliferation, invasion and sphere formation of OC cells. In addition, EMX2OS enhanced tumor growth in an in vivo xenograft model of human OC. 32273754 EMX2OS LncRNA Homo sapiens Prostatic Neoplasms PCa tissues regulation[cGMP-PKG pathway] qRT-PCR//RNA Pull-Down//ChIP TCF12 and EMX2OS were both downregulated in PCa tissues and cells,EMX2OS, transcriptionally regulated by TCF12, played a synergy role with FUS protein in regulating the proliferation, migration and invasion of PCa cells by activating the cGMP-PKG pathway. Yes TCF12 and EMX2OS were both downregulated in PCa tissues and cells, and they negatively regulated cell proliferation, migration and invasion, and activated cGMP-PKG pathway in DU145 and PC3 cells. 32801740 EMX2OS LncRNA Homo sapiens Wilms Tumor Wilms' tumor patient samples Interaction(miR-654-3p) Other EMX2OS expression was lower, while miR-654-3p level was higher in Wilms' tumor patient samples, and there was a negative correlation between EMX2OS and miR-654-3p. EMX2OS acted as a sponge of miR-654-3p. Overexpression of miR-654-3p abolished EMX2OS-mediated anti-cancer effects on Wilms' tumor cells. Yes Overexpression of EMX2OS repressed growth, migration, invasion, and triggered apoptosis of Wilms' tumor cells.Finally, EMX2OS overexpression restrained Wilms' tumor growth in vivo. 35181613 EMC9 CircRNA Homo sapiens Retinoblastoma RB tissues and cells Interaction(miR-138-5p/SLC7A5 axis) TUNEL//Western Blot//Transfection//Tunel//Flow Cytometry//qRT-PCR//Proliferation Assay//IF//PCR//Cell Proliferation Assay//IHC//Transwell Assay Circ-FAM158A and SLC7A5 were overexpressed and miR-138-5p was downregulated in RB tissues and cells. MiR-138-5p was a direct target of circ-FAM158A, and miR-138-5p inhibition reversed the inhibitory effect of circ-FAM158A silence on the progression of RB cells. Additionally, SLC7A5 was identified as a target of miR-138-5p, and SLC7A5 overexpression abated the anti-tumor roles of miR-138-5p in RB cells. Yes Circ-FAM158A knockdown inhibited RB cell proliferation, metastasis, and promoted apoptosis in vitro and in vivo. 34102206 EMBP1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC cell lines and tumor tissue regulation[EMBP1/miR-9-5p axis] qRT-PCR miR-9-5p was significantly down-regulated, and EMBP1 was significantly up-regulated, in RCC cell lines and tumor tissue. Our findings suggest an important role of the EMBP1/miR-9-5p axis dysregulation in RCC tumor progression. Yes Overexpression of miR-9-5p or EMBP1 suppression in RCC cell lines significantly retarded their proliferative, migratory, and invasive behavior, in addition to promoting apoptosis and cell-cycle arrest. 32482375 ELFN1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC cell lines Regulation(ZBTB16/PI3K/AKT axis) IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay Bioinformatics analysis revealed increased expression of ELFN1-AS1 in GC, and abundant expression of ELFN1-AS1 was observed in the acquired GC cell lines. ELFN1-AS1 recruited DNA methyltransferases to the promoter region of ZBTB16 and induced transcriptional repression of ZBTB16 through methylation modification. Furthermore, downregulation of ZBTB16 activated the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway and restored the proliferation and invasiveness of GC cells. Yes Knockdown of ELFN1-AS1 in GC cells weakened cell proliferation, invasion, migration, and resistance to apoptosis. In vivo, downregulation of ELFN1-AS1 reduced the growth rate of xenograft tumors in mice. 35451560 ELFN1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction( miR-497/CCNE1 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The significant upregulation of ELFN1-AS1 was found in NSCLC tissues and cells, which was closely associated with the TNM stage, lymph node metastasis status, and overall survival of patients. Moreover, ELFN1-AS1 was found to serve as a sponge to binding with miR-497, and CCNE1 was demonstrated to be the downstream target of miR-497, which was speculated as the potential mechanism underlying the function of ELFN1-AS1. The significant upregulation of ELFN1-AS1 was found in NSCLC tissues and cells, which was closely associated with the TNM stage, lymph node metastasis status, and overall survival of patients. Yes The knockdown of ELFN1-AS1 was found to inhibit the cellular processes and EMT of NSCLC. 35431233 EOLA1-DT LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Interaction( miR-3173-5p/SOCS3/JAK2/STAT3 pathway) In Vivo Experiment//RNA Pull-Down//IHC//Migration Assay//qRT-PCR//RIP//Cell Proliferation Assay//Colony Formation Assay LINC00893 was downregulated in PCa tissues and cell lines, and patients with low expression of LINC00893 were associated with a poorer overall survival rate.We further demonstrated that LINC00893 acted as a sponge for miR-3173-5p and inhibited its activity, which in turn regulated the suppressor of cytokine signaling 3 (SOCS3)/Janus Kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling axis. LINC00893 was downregulated in PCa tissues and cell lines, and patients with low expression of LINC00893 were associated with a poorer overall survival rate. Yes LINC00893 overexpression hindered the proliferation, epithelial-mesenchymal transition (EMT) as well as the migratory ability of PCa cells, and suppressed the tumorigenesis of PCa cells in nude mice. 35818076 EOLA2-DT LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues and cells Interaction(TIA-1/let-7e-5p ) Western Blot//Transfection//RIP//qRT-PCR//Luciferase Report Assay//Invasion Assay We found that LINC00894 expression was markedly reduced in thyroid cancer tissues and cells, and low expression of LINC00894 was associated with poor prognosis in thyroid cancer. Additionally, let-7e-5p expression was substantially enhanced in CAL-62 and TPC-1 cells. LINC00894 overexpression promoted TIA-1 expression by acting as a sponge of let-7e-5p. Finally, let-7e-5p weakened the function of LINC00894 in thyroid cancer cells via reduction in TIA-1 levels. We found that LINC00894 expression was markedly reduced in thyroid cancer tissues and cells, and low expression of LINC00894 was associated with poor prognosis in thyroid cancer. Yes LINC00894 overexpression inhibited the proliferation, migration, and invasion of CAL-62 and TPC-1 cells. 35776220 EPIST LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells Regulation[ miR-637/RING1 axis] qRT-PCR//Luciferase Report Assay//RIP We found that lncRNAC5orf66-AS1 was significantly upregulated in cervical cancer tissues and cells. LncRNA C5orf66-AS1, as a competitive endogenous RNA (ceRNA), regulated the effect of RING1 on the proliferation, apoptosis and cell cycle of cervical cancer cells through adsorbing miR-637. Yes Over-expression of C5orf66-AS1 promoted the proliferation of cervical cancer cells, while downregulation of C5orf66-AS1 promoted the apoptosis of cervical cancer cells. 30518760 EOLA2-DT LncRNA Homo sapiens Breast Neoplasms breast cancer cells Interaction(miR-429) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay High expression of LINC00894 was observed in breast cancer cells, and its overexpression significantly expedited cell proliferation and invasion. Moreover, LINC00894 positively regulated the expression of ZEB1 by competitively binding to miR-429. Yes High expression of LINC00894 was observed in breast cancer cells, and its overexpression significantly expedited cell proliferation and invasion. 34079285 EPIST LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Interaction(miR-149-5p/CTCF) RNA Pull-Down//ChIP//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this study, we tested C5orf66-AS1 expression in TNBC cells using quantitative real-time PCR (qRT-PCR) and used functional assays to detect cell behaviors, which showed that C5orf66-AS1 was highly expressed in TNBC cells and that C5orf66-AS1 knockdown attenuated cell proliferation, migration, and invasion while promoting cell apoptosis. Through a luciferase reporter assay, RNA immunoprecipitation (RIP) assay, and chromatin immunoprecipitation (ChIP) assay, we identified the binding capacity of C5orf66-AS1 to RNAs. Furthermore, miR-149-5p was proven to be sponged by C5orf66-AS1. CCCTC-binding factor (CTCF) was confirmed as the target of miR-149-5p and could transcriptionally activate C5orf66-AS1 expression in TNBC cells. We also discovered that C5orf66-AS1 activated the Wnt/β-catenin signaling pathway by upregulating catenin beta 1 (CTNNB1). Importantly, CTNNB1 could be targeted by miR-149-5p. Yes In this study, we tested C5orf66-AS1 expression in TNBC cells using quantitative real-time PCR (qRT-PCR) and used functional assays to detect cell behaviors, which showed that C5orf66-AS1 was highly expressed in TNBC cells and that C5orf66-AS1 knockdown attenuated cell proliferation, migration, and invasion while promoting cell apoptosis. 35499320 EPIC1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation(Ang2/Tie2 axis) qRT-PCR EPIC1 expression was significantly upregulated in NSCLC tissues and cell lines. We postulate that EPIC1 promotes tumor angiogenesis by activating the Ang2/Tie2 axis in NSCLC. Yes Furthermore, the overexpression of EPIC1 in NSCLC cells stimulated HUVEC channel formation and proliferation by activating Ang2/Tie2 signaling, and the opposite results were obtained when EPIC1 was silenced in NSCLC cells. The density of new blood vessels was simultaneously increased by EPIC1 overexpression in vivo, using CAM angiogenesis model and a nude mouse tumor model. 33359744 EPIC1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues,epithelial cells interaction[MYC] qRT-PCR We show that Lnc-EPIC1 expression is significantly higher in established/primary human lung cancer cells than that in human lung epithelial cells. Lnc-EPIC1 is also elevated in human lung cancer tissues. Together, our results show that Lnc-EPIC1 promotes human lung cancer cell growth possibly by targeting MYC. Yes Silencing of Lnc-EPIC1 by targeted siRNA significantly inhibited human lung cancer cell growth, survival and proliferation, whiling inducing G1-S cell cycle arrest and cell apoptosis. 30029875 EPIC1 LncRNA Homo sapiens Colonic Neoplasms colon tissues and colon epithelial cells Expression[highly expressed] qRT-PCR//IP//RNA Pull-Down We show that Lnc-EPIC1 expression is elevated in human colon cancer tissues and primary human colon cancer cells. Yes In the primary human colon cancer cells, Lnc-EPIC1 siRNA largely inhibited cancer cell growth, proliferation, migration and invasion. Further, Lnc-EPIC1 silencing induced significant apoptosis activation in colon cancer cells. 33170148 EPIC1 LncRNA Homo sapiens Osteosarcoma OS tissues and OS cell lines Interaction[MEF2D ] qRT-PCR//MTT//Transwell Assay//Western Blot EPIC1 was down-regulated, but MEF2D was up-regulated in OS tissues and OS cell lines.Targeting relationship between EPIC1 and MEF2D was confirmed by RNA pull-down and RNA immunoprecipitation (RIP). The MEF2D protein binding to ubiquitin was significantly increased in OS cells overexpressing EPIC1. The co-transfection with pcDNA-EPIC1 and pcDNA-MEF2D rescued the inhibition of cell viability and invasion caused by the overexpression of EPIC1. Yes Overexpression of EPIC1 inhibited cell viability and invasion of OS cells.Overexpression of EPIC1 suppressed tumor growth in the OS xenograft model. 30703420 EPIC1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissue Interaction[YAP1 ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Colony Formation Assay In this study, we found that the expression of the lncRNA EPIC1 (Lnc-EPIC1) is high in PC and closely related to tumor size, TNM staging and lymph node metastasis status.The results show that Lnc-EPIC1 interacts with YAP1 to promote the progression of PC. In this study, we found that the expression of the lncRNA EPIC1 (Lnc-EPIC1) is high in PC and closely related to tumor size, TNM staging and lymph node metastasis status. Yes Silencing Lnc-EPIC1 by siRNA targeting could significantly inhibit the cell growth and colony formation ability of PC cells and induced G1/S cell cycle arrest and apoptosis in PC cells. An Lnc-EPIC1-overexpressing lentiviral vector promoted the growth of PC cells. 31810603 EPIC1 LncRNA Homo sapiens Gallbladder Neoplasms plasma and paracancerous tissues of GBC patients Interaction(LncRNA LET) CCK8//qPCR//Cell Apoptosis Assay The present study found that EPIC1 was upregulated in tumor tissues than in paracancerous tissues of GBC patients, and plasma levels of EPIC1 were significantly correlated with levels of EPIC1 in tumor tissues. LncRNA LET was downregulated in tumor tissues than in paracancerous tissues and was inversely correlated with EPIC1 in both tumor tissues and paracancerous tissues. Yes Overexpression of EPIC1 led to downregulated LET, and LET overexpression also mediated the downregulation of EPIC1. EPIC1 led to accelerated GBC cell proliferation and inhibited apoptosis. Overexpression of LET played opposites roles. 34653690 EPIC1 LncRNA Homo sapiens Cholangiocarcinoma cholangiocarcinoma tissues Expression[highly expressed] Flow Cytometry//qRT-PCR//RIP//MTT//Colony Formation Assay In this study, our results indicate that the LncRNA-EPIC1 expression were significantly increased in cholangiocarcinoma tissues, compared to adjacent normal tissues. Yes Loss-and-gain of Lnc-EPIC1 contributes to the CCA cell growth, colony formation, cell apoptosis and also cell cycle. 30205958 EPHB4 CircRNA Homo sapiens Glioma glioma tissues and cell lines regulation[circEPHB4/miR-637/SOX10/Nestin axis] colony Formation Assay//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//PCR//IP//Colony Formation Assay//IF Here, we found that circEPHB4 (hsa_circ_0081519) and SOX10 were up-regulated and microRNA (miR)-637 was down-regulated in glioma tissues and cell lines. In conclusion, the circEPHB4/miR-637/SOX10/Nestin axis plays a central role in controlling stem properties, self-renewal and glycolysis of glioma cells and predicts the overall survival of glioma patients. Yes Functionally, silencing circEPHB4 or increasing miR-637 levels in glioma cells was sufficient to inhibit xenograft growth in vivo. 33085838 EPEL LncRNA Homo sapiens Osteosarcoma osteosarcoma tumors Interaction[ROCK1 ] qRT-PCR//Western Blot//Transwell Assay The results revealed that EPEL was Expression[Expression[up-expression]-expression]regulated in tumor tissues compared with adjacent tissues. Furthermore, EPEL overexpression promoted the migration and invasion of osteosarcoma cells and induced overexpression of ROCK1. Yes Furthermore, EPEL overexpression promoted the migration and invasion of osteosarcoma cells and induced overexpression of ROCK1. 30867743 EPB41L5 CircRNA Homo sapiens Glioblastoma glioblastoma tissues and cell lines interaction[EPB41L5,miR-19a] qRT-PCR//Luciferase Report Assay//RNA Pull-Down Circ-EPB41L5 was downregulated in glioblastoma tissues and cell lines compared to the normal brain tissues and cell lines. The current study highlights a novel suppressive function of circ-EPB41L5 and reveals that circ-EPB41L5/miR-19a/EPB41L5/p-AKT regulatory axis plays a striking role in the progression of glioblastoma, which provides a novel insight into the mechanisms underlying glioblastoma. Low circ-EPB41L5 expression was correlated to the poor prognosis of glioblastoma patients, while the overexpression inhibited proliferation, clone formation, migration, and invasion abilities of glioma cells, and the suppression had counter effects. Yes Low circ-EPB41L5 expression was correlated to the poor prognosis of glioblastoma patients, while the overexpression inhibited proliferation, clone formation, migration, and invasion abilities of glioma cells, and the suppression had counter effects. 31905344 EPB41L4A-DT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Regulation[miR-301a-5p-FOXL1 axis] FISH//Luciferase Report Assay//Western Blot//qRT-PCR Here, we have identified a novel lncRNA EPB41L4A-AS2, which is significantly downregulated both in HCC cells and tissues, and plays a negative regulatory role in HCC proliferation and invasion. Yes Also, in vivo experiments proved that EPB41L4A-AS2 suppress tumor growth and extrahepatic metastasis (lung) via the miR-301a-5p-FOXL1 axis. 30971290 EPB41L4A-DT LncRNA Homo sapiens Ovarian Neoplasms cell lines Interaction[microRNA-103a] Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Microarray//Transwell Assay RT-qPCR was conducted to detect the expression of EPB41L4A-AS2 in 126 OC tissues and paracancerous tissues, the results of which documented that EPB41L4A-AS2 was poorly expressed in OC tissues compared with in paracancerous tissues (P < 0.05; Figure 1b). RUNX1T1 was a target gene of miR-103a and EPB41L4A-AS2 bound to miR-103a. Moreover, EPB41L4A-AS2 increased RUNX1T1 expression by decreasing miR-103a expression. EPB41L4A-AS2-overexpressing SK-OV-3 cells exhibited inhibited proliferation, migration, colony formation and invasion, which was rescued by overexpression of miR-103a or silencing of RUNX1T1. Besides, overexpressed EPB41L4A-AS2 repressed tumour formation in vivo. Altogether, the current study demonstrates that overexpressed EPB41L4A-AS2 can potentially bind to miR-103a to promote the expression of RUNX1T1, thereby inhibiting OC, highlighting the potential of EPB41L4A-AS2 as a target for OC. Yes EPB41L4A-AS2 increased RUNX1T1 expression by decreasing miR-103a expression. EPB41L4A-AS2-overexpressing SK-OV-3 cells exhibited inhibited proliferation, migration, colony formation and invasion, which was rescued by overexpression of miR-103a or silencing of RUNX1T1. Besides, overexpressed EPB41L4A-AS2 repressed tumour formation in vivo. 31645082 EPB41L4A-DT LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction(MiR-107/LATS2 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Cycle Assay//EdU Staining//Transwell Assay Mechanistically, in the nucleus we identified that EPB41L4A-AS2 relies on binding to YBX1 to reduce the stability of Snail mRNA to enhance the expression of E-cadherin and reverse the progression of epithelial-to-mesenchymal transition (EMT). In the cytoplasm, we found that EPB41L4A-AS2 blocked the invasion and migration of NPC cells by promoting LATS2 expression via sponging miR-107. Yes Biological analyses showed that overexpression of EPB41L4A-AS2 reduced the metastasis and invasion of NPC in vitro and in vivo, but had no significant effect on cell proliferation. 34131399 EPB41L4A-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[Rho/ROCK pathway] qRT-PCR In this study, we found that lncRNA EPB41L4A-AS1 was highly expressed in CRC tissues and was associated with poor prognosis and tumor metastasis in patients with CRC. Mechanically, we found that EPB41L4A-AS1 may participate in the development of CRC by activating the Rho/Rho-associated protein kinase signaling pathway. Yes In vitro studies showed that the knockdown of EPB41L4A-AS1 inhibited the proliferation, migration, invasion, and epithelial-mesenchymal transition of CRC cells. 32557646 EPB41L4A-AS1 LncRNA Homo sapiens Aging neurons and glial-derived cells. Regulation(damaging synthesis of NAD+ and ATP) Western Blot//Transfection//qRT-PCR//Bioinformatics Analysis//ChIP EPB41L4A-AS1 was downregulated in aging and Alzheimer's disease. EPB41L4A-AS1 related genes were found to be enriched in the electron transport chain and NAD synthesis pathway. Furthermore, these genes were highly associated with neurodegenerative diseases and positively correlated with EPB41L4A-AS1. In addition, biological experiments proved that the downregulation of EPB41L4A-AS1 could reduce the expression of these genes via histone H3 lysine 27 acetylation, resulting in decreased NAD and ATP levels, while EPB41L4A-AS1 overexpression and nicotinamide riboside treatment could restore the NAD and ATP levels. Yes biological experiments proved that the downregulation of EPB41L4A-AS1 could reduce the expression of these genes via histone H3 lysine 27 acetylation, resulting in decreased NAD and ATP levels, while EPB41L4A-AS1 overexpression and nicotinamide riboside treatment could restore the NAD and ATP levels. 34758883 EPB41 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-486-3p/eIF5A axis) Western Blot//ISH//Transfection//qPCR//Proliferation Assay//FISH//RIP//IF//RNA-seq//PCR//Cell Proliferation Assay//IP//Transwell Assay The results show that the circ-EPB41 was upregulated in NSCLC tissues and cell lines. Luciferase reporter experiments confirmed that miR-486-3p/eIF5A were downstream targets of circ-EPB41. Increased circ-EPB41 expression in NSCLC was significantly correlated with malignant characteristics, and positive to post-surgical overall survival of NSCLC patients. Yes Reduced circ-EPB41 expression in NSCLC decreased cell proliferation and invasion in both in vitro and in vivo experiments. 35725615 FAM225A LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction( MiR-206/ADAM12 ) IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay//Transwell Assay In gastric cancer, FAM225A and ADAM12 expressions were up-regulated, while miR-206 expression was down-regulated. MiR-206 inhibitor partially offset the effects of siFAM225A. Moreover, FAM225A competitively bound to miR-206 to up-regulate ADAM12 expression. Overexpressed ADAM12 partially reversed the effect of miR-206 mimic on the biological characteristics of gastric cancer cells and EMT-related proteins. Yes Opposite to the regulatory effects of overexpressed FAM225A, blocking FAM225A expression reduced cell viability, migration, invasion and number of cell clones, increased E-Cadherin expression, inhibited N-Cadherin and Vimentin expressions, and ultimately promoted tumor growth. 34539984 FAM225B LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction(miR-613/CCND2 axis) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay We observed a remarkable increase of FAM225B in NPC tissues and cell lines compared with controls. Mechanically, FAM225B functioned as an endogenous sponge by competing for miR-613 binding to up-regulate CCND2 expression. More importantly, rescue experiments further demonstrated that the suppressive impacts of FAM225B knockdown on cell proliferation, migration and invasion were significantly reversed after CCND2 overexpression. Also, highly expressed FAM225B was closely correlated with advanced TNM stage, distant metastasis, and poor overall survival. Yes Interestingly, loss-of-function analysis revealed that FAM225B knockdown significantly inhibited tumor growth in vitro and in vivo, and decreased the migratory and invasive capacity of NPC cells. 34255617 FAM230B LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Interaction(miR-378a-3p/WNT5A axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Invasion Assay//Migration Assay//qRT-PCR//RNA-seq//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis In this study, we found consistently elevated expression levels of the lncRNA FAM230B in PTC tissues, both in newly generated RNA-seq data and in datasets from the GEO and TCGA databases. Mechanistically, FAM230B sponged miR-378a-3p and showed competitive binding to the 3'-UTR of WNT5A. FAM230B overexpression resulted in elevated WNT5A expression and thereby regulated the epithelial-mesenchymal transition in PTC cells. Finally, we verified that both miR-378a-3p overexpression and WNT5A silencing effectively offset the impacts of FAM230B on PTC cell migration and invasion. We demonstrated that the expression of FAM230B can be used for the diagnosis of PTC and is also strongly associated with lymph node metastasis. Yes Functionally, FAM230B promoted the migration and invasion of PTC cells in vitro and in vivo. 33578293 FER1L4 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cancer cell lines Interaction(miR-133a-5p/Prx1 Axis) CCK8//qRT-PCR FERIL4 was significantly upregulated in OSCC tissues and cancer cell lines. Knockdown of FER1L4 significantly enhanced the expression of miR-133a-5p by sponging it, and then downregulated Prx1 expression. Moreover, high level of FER1L4 predicted a poor prognosis of OSCC patients. Yes Silencing of FER1L4 not only significantly inhibited cell growth, invasion, migration and induced apoptosis in SCC-9 and HN4 cells in vitro, but also effectively suppressed the tumorigenesis of OSCC cells in vivo. 33568918 FER1L4 LncRNA Homo sapiens Osteosarcoma cell lines Regulation[PI3K/AKT signaling pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay Results showed that FER1L4 was observed to be lowly expressed in osteosarcoma cell lines (US-O2, MG-63 and SaOS-2 cells), especially MG63 cells.In conclusion, the study indicated that FER1L4 acted as a tumor suppressor in osteosarcoma via activating PI3K/AKT pathway may be a new prognostic biomarker and potential therapeutic target for osteosarcoma intervention. Yes Besides, overexpression of FER1L4 remarkably repressed the proliferation, migration and invasion of MG63 cells. 31000382 FER1L4 LncRNA Homo sapiens Parkinson Disease Neural stem cells Interaction( miR-874-3p/Ascl2) qRT-PCR//Western Blot In the present research, we noted that FER1L4 is upregulated in NSCs induced with TNFα. Using Starbase online software, we identified that FER1L4 is one potential target gene of miR-874-3p. Ectopic expression of FER1L4 decreases miR-874-3p expression in NSCs. We identified Ascl2 is one target gene for miR-874-3p. Overexpression of FER1L4 enhances Ascl2 expression in NSCs. Furthermore, we proved that FER1L4 modulates the proliferation and differentiation of NSCs via regulating Ascl2. Yes Ectopic expression of FER1L4 suppresses NSCs proliferation and induces NSCs differentiated into neurons and astrocytes. 35559379 FER1L4 LncRNA Homo sapiens Glioma glioma tissues Interaction[FER1L4/miR-372/E2F1] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot In this study, it was found that the expression of LncRNA FER1L4 is upregulated in high-grade gliomas than in low-grade cases and that a high expression of LncRNA FER1L4 predicts poor prognosis of gliomas.Besides, it is found in our study that LncRNA FER1L4 expression is positively correlated with E2F1 mRNA expression. After knockdown of FER1L4 expression, E2F1 expression is significantly down-regulated, whereas the expression of miR-372 is significantly up-regulated; the up-regulation of miR-372 leads to significant down-regulation of FER1L4 and E2F1 expression. In addition, it is also found that FER1L4 can be used as competitive endogenous RNA to interact or bind with miR-371 and thereby up-regulate E2F1, thus promoting the cycle and proliferation of glioma cells. It may be one of the molecular mechanisms in which FER1L4 plays its oncogene-like role in gliomas. Yes Meanwhile, in vitro study suggests that expression of FER1L4 with SiRNA knockdown obviously suppresses cell cycle and proliferation. It is further demonstrated by experiments that the FER1L4 knockdown suppresses growth of in vivo glioma. 30887657 FER1L4 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Interaction( miR-612/ Cadherin 4 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//IHC//Invasion Assay Upregulated expression of FER1L4 in PTC tissues was positively correlated with lymph node metastasis (P = 0.020), extrathyroidal extension (P = 0.013) and advanced TNM stages (P = 0.013). Mechanistically, FER1L4 could competitively bind with miR-612 to prevent the degradation of its target gene CDH4. This condition was further confirmed in the rescue assays. Upregulated expression of FER1L4 in PTC tissues was positively correlated with lymph node metastasis (P = 0.020), extrathyroidal extension (P = 0.013) and advanced TNM stages (P = 0.013). Yes In addition, knockdown of FER1L4 suppressed PTC cell proliferation, migration, and invasion, whereas ectopic expression of FER1L4 inversely promoted these processes. 34289835 FER1L4 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cell lines regulation[AKT/ERK signaling pathway] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay The results of the present study revealed that FER1L4 expression levels were downregulated in AMC?HN?8 and Tu 686 cells.Further studies indicated that the aforementioned changes could be reversed by IGF‑1, indicating FER1L4 may regulate the progression of LSCC cells by inhibiting the AKT/ERK signaling pathway. Yes Notably, FER1L overexpression significantly reduced the cell viability, proliferation, migration and invasion of LSCC cells, while promoting apoptosis. 33174027 FER1L4 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues interaction[miR-92a-3p,FBXW7] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//Western Blot It was found that FER1L4 was lower in prostate cancer tissues than normal tissues. Bioinformatic analysis, RT-qPCR, RNA pull down assay and dual luciferase assay showed that FER1L4 upregulated F-box/WD repeat-containing protein 7 (FBXW7) tumor suppressor via sponging miR-92a-3p. Yes Overexpression of FER1L4 inhibited cell proliferation and promoted cell apoptosis in prostate cancer cells. 32140077 FENDRR-205 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues,cell lines Expression[lower expressed] qRT-PCR//RNA-seq Subsequently, four lncRNAs (upregulated ENST00000433108; downregulated ENST00000598996, ENST00000524265 and ENST00000398461) and two mRNAs (upregulated CCNB1 and CDK1) in 64 pairs of BC and adjacent normal tissues and four BC cell lines were detected using reverse transcription?quantitative PCR and these results were consistent with the sequencing data. The low expression level of ENST00000598996 and ENST00000524265 was correlated with unfavorable clinicopathological parameters, and shorter progression?free and overall survival time, whereas, ENST00000433108 was not associated with either. Yes The in vitro functional experiments also revealed that the overexpression of ENST00000598996 and ENST00000524265 decreased the proliferation, migration, and invasion abilities of BC cells. 33000254 FENDRR LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-421/SIRT3/Notch-1 Axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Invasion Assay//Transwell Assay FENDRR expression was downregulated in GC tissues and cell lines. MiR-421 mimic reversed the inhibitory effect of FENDRR on the growth of AGS and SGC-7901 cells. Yes Overexpression of FENDRR or SIRT3 inhibited tumor proliferation and invasion, and promoted apoptosis.The overexpression of Notch-1 reversed the inhibitory effect of SIRT3 on AGS cell. MiR-421 mimic reversed the inhibitory effect of FENDRR on the growth of AGS and SGC-7901 cells. Nude mice injected with FENDRR overexpressing AGS cells had smaller tumor volume and weight and weaker tumor cell proliferation ability. 34938121 FENDRR LncRNA Homo sapiens Breast Neoplasms breast cancer cell lines and tissues Expression [lower expressed] Wound Healing Assay//Colony Formation Assay//Migration Assay//qRT-PCR//MTT//IHC//Transwell Assay We found that FENDRR expression was lower in breast cancer cell lines and cancerous tissues than in the adjacent normal tissues. Low expression of FENDRR was associated with a shorter overall survival and a shorter progression-free survival in breast cancer patients (p<0.001, p<0.001, respectively). Yes We found that FENDRR inhibits breast cancer cell proliferation and migration and promotes cell apoptosis, while FENDRR knockdown promotes breast cancer cell proliferation and migration and suppresses cell apoptosis. Finally, we also detected that FENDRR overexpression could inhibit tumor growth in a xenograft model. 29559798 FENDRR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues interaction[miR-761] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//IHC//Transwell Assay We found a marked down-regulation of FENDRR in NSCLC tissues compared to tumor-adjacent tissues. We found that FENDRR was down-expressed in NSCLC and the over-expression of FENDRR inhibited the malignant phenotypes of NSCLC cell by binding to miR-761 competitively. Low expression of FENDRR was identified as a predictive factor for poor prognosis of patients with NSCLC. Yes The over-regulation of FENDRR inhibited the proliferation, migration and invasion capacities of NSCLC cell and promoted the apoptosis of NSCLC cell in vitro whereas the down-regulation of FENDRR caused the opposite results. Moreover, the over-expression of FENDRR restrained the growth of NSCLC cell in vivo. 30556873 FENDRR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues,cell line Expression[lower expressed] qRT-PCR We found that lncRNA FENDRR expression was significantly decreased in lung cancer tissues and cells, especially in NSCLC cells. Yes Then we constructed NSCLC cells with FENDRR stable overexpression and revealed that FENDRR overexpression attenuated the stemness of NSCLC cells, evident by decreased stemness markers expression and capacity of cell spheroid formation. 30981768 FENDRR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Regulation[miR-761/TIMP2 axis] Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay we found that FENDRR was downregulated in lung adenocarcinoma (LUAD) or lung squamous cell carcinoma (LUSC) tissue compared to that in normal tissue (Fig. 1B). Further prognostic analysis using Kaplan-Meier Plotter (http://kmplot.com/analysis/index.php?p = service&cancer = lung) revealed that the overall survival of patients with low level of FENDRR was worse when compared to that patient had high level of FENDEE (Fig. 1C). Yes As shown in Fig. 2C, D, up-regulation of FENDRR reduced the proliferation of H1975 and A549 cells, while si-FENDRR promoted the growth of H1975 and A549 cells. We also observed that down-regulation of FENDRR enhanced the colony formation of NSCLC cells whereas over-expression of FENDRR reduced the colony formation of NSCLC cells (Fig. 2E-2 F). 31545237 FENDRR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[ miR-18a-5p/ING4 axis] qRT-PCR In this study, we reveal that lncRNA FENDRR is downregulated in CRC and negatively correlated with advanced stage and poor clinical outcomes of patient with CRC.Mechanistically, FENDRR interacts with miRNA-18a-5p (miR-18a-5p) and subsequently regulates the expression of inhibitor of growth 4 (ING4) in CRC cell. Interestingly, ING4 repression or miR-18a-5p rescues FENDRR induced proliferation and aggressive phenotypes inhibition of CRC cell. Yes Overexpression of FENDRR represses the proliferation, migrate and invasive capacities of CRC cell in vitro, and upregulation of FENDRR inhibits the growth and distant metastatic capacity of CRC cell in vivo. 31724220 FENDRR LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer cells Interaction(Sox2 mRNA 3'UTR) CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Here, we identified that lncRNA FENDRR level was remarkably lower in spheres formed by colorectal cancer cells compared to that in parental cancer cells. Yes Overexpression of lncRNA FEDNRR attenuates the CSC-like traits of colorectal cancer spheres.Overexpression of lncRNA FEDNRR attenuates the CSC-like traits of colorectal cancer spheres. 34697986 FENDRR LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues,cell lines Interaction[repressing SOX4] CCK8//qRT-PCR//Transwell Assay//Western Blot We determined that attenuation of FENDRR was a frequent event in colon cancer tissues and colon cancer cell lines, in contrast to their normal counterparts. Furthermore, through a series of in vitro and in vivo assays, we reported the discovery of FENDRR modulating the expression of SOX4 protein, and hence in the progression of colon cancer. Yes Moreover, ectopic expression of FENDRR repressed colon cancer cell viability, invasion and epithelial-mesenchymal transition. 31213846 FENDRR LncRNA Homo sapiens Carcinoma, Hepatocellular Interaction[sponging miR-423-5p] RNA Pull-Down//Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//Microarray//ELISA//EdU Staining Therefore, this study's main purpose was to explore the mechanism of tumor suppressor lncRNA FENDRR in regulating the immune escape of HCC cells. Notably, it was further validated through this study that lncRNA FENDRR competitively bound to microRNA-423-5p (miR-423-5p), and miR-423-5p specifically targeted growth arrest and DNA-damage-inducible beta protein (GADD45B). The effects that lncRNA FENDRR and miR-423-5p have on the cell proliferation and apoptosis, the immune capacity of regulatory T cells (Tregs), and the tumorigenicity of HCC cells were examined through overexpressing or the knocking down of lncRNA FENDRR and miR-423-5p both in vitro and in vivo. Subsequently, lncRNA FENDRR and GADD45B were revealed to have poor expressions in HCC. Meanwhile, miR-423-5p was highly expressed in HCC. Yes Importantly, overexpressed lncRNA FENDRR and downregulated miR-423-5p diminished cell proliferation and tumorigenicity, and promoted apoptosis in HCC cells, thus regulating the immune escape of HCC mediated by Tregs. 31351327 FENDRR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[ down-regulating glypican-3] CCK8//qRT-PCR//Western Blot We found that the expression levels of FENDRR were significantly down-regulated in HCC tissues and cells.Taken together, we provided the first evidence for the inhibitory activity of FENDRR in HCC, which is causally linked to targeting GPC3 at the epigenetic level. Restoration of FENDRR may be a potential approach to prevent HCC progression and metastasis. Yes FENDRR overexpression could inhibit the growth of HCC cells in vitro and in vivo.Moreover, up-regulation of FENDRR suppressed the migration and invasion of HCC cells. 30573358 FENDRR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck CAFs Regulation(PI3K/AKT Pathway) qRT-PCR//Western Blot Quantitative polymerase chain reaction (qPCR) results demonstrated that FENDRR expression is lower in CAFs compared to normal fibroblasts (NFs) of OSCC patients. Further experiments confirmed that the downregulation of FENDRR can activate the PI3K/AKT pathway in NFs and enhances the expression of matrix metalloproteinase 9 (MMP9). Yes Besides, we co-cultured human umbilical vein endothelial cells (HUVECs) with CAFs, and the tube-forming ability of HUVECs co-cultured with CAFs overexpressing FENDRR decreased significantly. However, activation of the AKT pathway of CAFs overexpressing FENDRR can weaken the inhibitory effect of FENDRR on angiogenesis. 34327132 FENDRR LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines interaction[EZH2] Wound Healing Assay//CCK8//qRT-PCR//RIP//Transwell Assay The results revealed that lincFOXF1 expression is significantly decreased and strongly related to Enneking stage as well as metastasis in osteosarcoma patients.The present findings indicate that lincFOXF1 is involved in the progression of osteosarcoma through binding with EZH2, further regulating GIT1 expression. The results revealed that lincFOXF1 expression is significantly decreased and strongly related to Enneking stage as well as metastasis in osteosarcoma patients. Yes Further experiments showed that lincFOXF1 inhibits the migration, invasion and metastasis of cells in vitro and vivo. 32945076 FER1L4 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction[PI3K/AKT pathway] qRT-PCR//Western Blot In the present study, the levels of FER1L4 were decreased significantly in OS tissues and cell lines compared with non-tumorous tissues or hFOB1.19. In addition, the expression of PI3K, p-AKT (Ser470) and p-AKT (Thr308) was upregulated by siFER1L4, while decreased upon overexpression of FER1L4. MicroRNA (miRNA) -18a-5p, an osteosarcoma-promoting miRNA which was suggested a target of FER1L4 in osteosarcoma, was identified to be a functional target of FER1L4 on the regulating of cell apoptosis and EMT, presently. The effects of FER1L4 overexpression on the markers of cell apoptosis, proliferation, EMT, and stemness and PI3K/AKT signaling were all reversed by miR-18a-5p upregulation. Furthermore, the suppressor of cytokine signaling 5 (SOCS5) was confirmed a target gene of miR-18a-5p by luciferase gene reporter assay and SOCS5 suppression by miR-18a-5p attenuated the effects of FER1L4 overexpression on the OS cells apoptosis and the expressed levels of PI3K, AKT, Twist1, N-cadherin and Vimentin. In conclusion, our data indicated thatthe overexpression of FER1L4 promoted apoptosis and inhibited the EMT markers expression and PI3K/AKT signaling pathway activation in OS cells via downregulating miR-18a-5p to promote SOCS5. Yes Knockdown of FER1L4 in OS cells decreased the apoptosis rate, but increased the OS cell proliferation, upregulated the expression levels of CD133 and Nanog, as well as promoted Twist1 expression, increased the N-cadherin and Vimentin expression. 31473323 FER1L4 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction[ PI3K/AKT signal pathway] qRT-PCR//Wound Healing Assay//Western Blot Downregulation of FER1L4 in hepatocellular carcinoma tissues and cells was demonstrated by qRT-PCR analysis. Importantly, Western blot assays revealed that PII3K/AKT signal pathway were involved in mediating the progression regulation role of FER1L4 in HCC cells. Yes Besides, FER1L4 overexpression evidently attenuated the cell proliferation, migration and invasion, but prompted cell apoptosis. 30382631 FAM230B LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow mononuclear cells Interaction(MiR-140) BrdU//qRT-PCR//RNA Pull-Down High FAM230B expression level and low miR-140 expression level were observed in AML.FAM230B and miR-140 were inversely correlated and directly interacted with each other. FAM230B could be detected in both cytoplasm and nuclear samples. MiR-140 overexpression downregulated FAM230B expression and suppressed the enhancing effects of FAM230B overexpression on cell proliferation. Yes MiR-140 overexpression downregulated FAM230B expression and suppressed the enhancing effects of FAM230B overexpression on cell proliferation. 35666685 FER1L4 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[PTEN ] qRT-PCR//MTT//Colony Formation Assay//Western Blot The results indicated that FER1L4 was expressed at a low level in human HCC tissues compared with adjacent normal tissues.In addition, PTEN was highly expressed in HCC tissues compared with normal adjacent tissues and was positively associated with FER1L4. Yes Functional studies indicated that FER1L4 may inhibit the proliferative ability of HCC cells. In addition, it was demonstrated that FER1L4 inhibited the proliferative ability of HCC cells in vitro, and silencing FER1L4 expression by small interfering RNAs promoted the growth of HCC tumors in vivo. 30431133 FEZF1-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells regulation[miR-144/CXCR4 axis] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay The levels of FEZF1-AS1 and CXCR4 were strikingly up-regulated, and miR-144 was notably down-regulated in OS tissues and cells. Furthermore, FEZF1-AS1 promoted cell proliferation, Warburg effect and suppressed cell apoptosis in osteosarcoma via miR-144/CXCR4 axis, this novel pathway may provide a basis for the further study of osteosarcoma. Yes Functionally, FEZF1-AS1 silencing or miR-144 overexpression inhibited cell viability, the glucose and lactate productions and promoted cell apoptosis in Saos-2 and HOS cells. 32308422 FEZF1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction(miRNA-1254) Western Blot//ISH//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay By clinical analysis, lncRNA FEZF1-AS1 was high expression in cervical cancer tissues and high expression was closely correlated with poor prognosis in cervical cancer patients. However, with miR-1254 expression inhibiting, the cell biological activities were significantly increased in si-FEZF1-AS1+miRNA inhibitor groups (p < .001, respectively). By clinical analysis, lncRNA FEZF1-AS1 was high expression in cervical cancer tissues and high expression was closely correlated with poor prognosis in cervical cancer patients. Yes In vitro study, the SiHa and HeLa cell biologically including cell proliferation, migration, and invasion of si-FEZF1-AS1 group which knockdown lncRNA FEZF1-AS1 were significantly depressed (p < .001, respectively). 34531986 FEZF1-AS1 LncRNA Homo sapiens Glioblastoma GBM cells Interaction(miR-363-3p/ NOB1) RNA Pull-Down//Western Blot//Tunel//Flow Cytometry//qRT-PCR//RIP//FISH//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay FEZF1-AS1 possessed high expression in GBM cells. With the help of bioinformatics prediction and mechanism assays, FEZF1-AS1 was found to bind to miR-363-3p and NOB1 was determined to be the downstream gene. Finally, results of rescue assays verified that the suppressive function of FEZF1-AS1 inhibition on GBM development were restored by miR-363-3p depletion or overexpression of NOB1. Yes Down-regulation of FEZF1-AS1 suppressed GBM cell proliferation, migration and invasion while inducing cell apoptosis. 34530115 FEZF1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[ITGA11/miR-516b-5p axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Microarray In the present study, FEZF1?AS1 was selected using Arraystar Human lncRNA microarray and was identified to be upregulated in NSCLC tissues and negatively associated with the overall survival of patients with NSCLC. Overall, the present findings demonstrated that FEZF1‑AS1 was upregulated and acted as an oncogene in NSCLC by regulating the ITGA11/miR‑516b‑5p axis, suggesting that FEZF1‑AS1 may be a potential prognostic biomarker and therapeutic target for NSCLC. In the present study, FEZF1?AS1 was selected using Arraystar Human lncRNA microarray and was identified to be upregulated in NSCLC tissues and negatively associated with the overall survival of patients with NSCLC. Yes Loss?of?function assays revealed that FEZF1?AS1 inhibition decreased cell proliferation and migration, and arrested cells at the G2/M cell cycle phase. 33174014 FEZF1-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung (LAD) tissues and cell lines Interaction(FEZF1 ) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, we demonstrated that lncRNA forebrain embryonic zinc finger protein 1 (FEZF1) antisense RNA1 (FEZF1-AS1) is markedly upregulated in human lung adenocarcinoma (LAD) tissues and cell lines and is associated with poor prognosis.Further studies revealed that downregulation of FEZF1-AS1 reduced mRNA and protein expression of its sense-cognate gene FEZF1 in LAD cells, and vice versa. Correlation analysis indicated that there was a positive correlation between FEZF1-AS1 and FEZF1 expression in LAD tissues. Additionally, rescue assay confirmed that the function of FEZF1-AS1 in LAD was mediated by FEZF1. In the present study, we demonstrated that lncRNA forebrain embryonic zinc finger protein 1 (FEZF1) antisense RNA1 (FEZF1-AS1) is markedly upregulated in human lung adenocarcinoma (LAD) tissues and cell lines and is associated with poor prognosis. Yes Loss of function revealed that deletion of FEZF1-AS1 expression significantly inhibited the LAD cell proliferation, invasion, and migration. 29510777 FEZF1-AS1 LncRNA Homo sapiens Rectal Neoplasms rectal cancer tissues and cells. Interaction(miR-632/FAM83A axis) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay In the present study, we discover that FEZF1-AS1 is significantly upregulated in rectal cancer tissues and cells.Furthermore, FEZF1-AS1 functions as a competing endogenous RNA (ceRNA) for miR-632, resulting in the suppression of family with sequence similarity 83, member A (FAM83A). Yes Knocking down of FEZF1-AS1 suppresses cell proliferation, migration, and invasion , and tumorigenesis . 35607960 FEZF1-AS1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Regulation[Notch signaling] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay We found that FEZF1-AS1 expressions were distinctly reduced in human PCa tissues and cell lines compared with their non-tumor counterparts, and its higher levels were strongly associated with lymph node metastasis (p=0.012) and Angiolymphatic invasion (p=0.022). Mechanistic assays demonstrated that FEZF1-AS1 exhibited its tumor-promotive roles by activating the Notch signaling pathway. We found that FEZF1-AS1 expressions were distinctly reduced in human PCa tissues and cell lines compared with their non-tumor counterparts, and its higher levels were strongly associated with lymph node metastasis (p=0.012) and Angiolymphatic invasion (p=0.022). Then, Kaplan-Meier assays showed that patients with higher expressions of FEZF1-AS1 were shown to predict unfavorable overall survival. Yes Functional investigations suggested that knockdown of FEZF1-AS1 could suppress cells proliferation, trigger late apoptosis, and inhibit cells invasion and migration. 31298365 FEZF1-AS1 LncRNA Homo sapiens Retinoblastoma retina tissue,cell lines Expression[highly expressed] CCK8//qRT-PCR//Transwell Assay In our results, levels of FEZF1-AS1 expression were elevated in retinoblastoma tissue specimens and cell lines compared with adjacent normal retina tissue specimens and human retinal pigment epithelial cell line, respectively. he correlation analysis indicated that high FEZF1-AS1 expression was significantly correlated with present choroidal invasion and optic nerve invasion. Survival analysis suggested that retinoblastoma patients in high FEZF1-AS1 expression group had obviously short disease-free survival (DFS) compared with retinoblastoma patients in low FEZF1-AS1 expression group, and high FEZF1-AS1 expression was an independent unfavorable prognostic factor for DFS in retinoblastoma patients. Yes Loss-of-function study indicated silencing FEZF1-AS1 expression inhibited retinoblastoma cell proliferation, invasion and migration. 31076545 FEZF1-AS1 LncRNA Homo sapiens Retinoblastoma cells regulation[miR-1236-3p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results of the present study revealed that the levels of FEZF1?AS1 were significantly upregulated in different Rb cell lines, with the most prominent upregulation observed in Y79 cells.In conclusion, the findings of the present study suggested that lncRNA‑FEZF1‑AS1 may promote the viability, migration, invasion and EMT of Rb cells by modulating miR‑1236‑3p. Yes In addition, the cell viability, invasive and migratory abilities, and the ability to undergo epithelial?mesenchymal transition (EMT), were significantly inhibited following the transfection of short hairpin RNA (shRNA)?FEZF1?AS1 into Y79 cells. 32901841 FEZF1-AS1 LncRNA Homo sapiens Retinoblastoma retinoblastoma tissues and cells Interaction(miR-363-3p/PAX6) In Vivo Experiment//Western Blot//qPCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//IHC In current study, FEZF1-AS1 was up-regulated in retinoblastoma tissues and cells. The interaction between FEZF1-AS1 and microRNA-363-3p (miR-363-3p) was confirmed. FEZF1-AS1 down-regulated miR-363-3p and up-regulated PAX6. PAX6 was a target gene of miR-363-3p. EZF1-AS1 promoted retinoblastoma cell viability and suppressed apoptosis via PAX6. Yes FEZF1-AS1 overexpression enhanced retinoblastoma cell viability, promoted cell cycle, and inhibited apoptosis. Conversely, FEZF1-AS1 knockdown reduced cell viability, cycle, and elevated apoptosis. Further, we demonstrated that FEZF1-AS1 contribute to tumor formation in vivo. 33432525 FEZF1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells Interaction(MiR-367-3p/SLC12A5 Signal Axis) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay FEZF1-AS1 was highly expressed in CC cells. Importantly, mechanism experiments confirmed that miR-367-3p could bissnd to FEZF1-AS1 and SLC12A5. The rescue assays determined that FEZF1-AS1 could up-regulate SLC12A5 through binding to miR-367-3p. Yes . Moreover, FEZF1-AS1 depletion suppressed proliferation, migration, invasion, and induced cell apoptosis. 34362591 FEZF1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patients interaction[NOTCH1,miR-34a] qPCR//Western Blot//Transwell Assay FEZF1-AS1 was up-regulated in NSCLC patients. FEZF1-AS1 promoted NSCLC cell migration and invasion through the up-regulation of NOTCH1 by serving as a sponge of miR-34a. Increased expression levels of FEZF1-AS1 were observed with the increase in clinical stages. Yes Analysis of cell migration and invasion showed increased cell invasion and migration rates after FEZF1-AS1 and NOTCH-1 over-expression. 32349744 FEZF1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cells Interaction(miR-4497 targeting GBX2) Western Blot//Transfection//Wound Healing Assay//qPCR//CCK8//Luciferase Report Assay//Transwell Assay FEZF1-AS1 was highly expressed in LSCC tissues and cells. FEZF1-AS1 targeted and negatively modulated miR-4497. Inhibition of miR-4497 markedly restored the FEZF1-AS1 silence-repressed cell viability of TU686 and UM-SCC-17A cells. Further, FEZF1-AS1 could positively regulate GBX2 via negative regulation of miR-4497. Yes Silence or elevation of FEZF1-AS1 inhibited or promoted the migration and invasion of TU686 and UM-SCC-17A cells. 33550476 FERRE LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells regulation[miR-19a-5p/EZH2 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Results showed that expression of FERRE and EZH2 were upregulated in human breast cancer tissues and cells. We found that lncRNA-FERRE was upregulated in human breast cancer patients, which could accelerate tumor proliferation, migration and invasion as a molecular sponge by modulating the inhibitory effect of miR-19a-5p on oncogene EZH2. Yes qRT-PCR and CCK-8 assay showed that FERRE expression is associated with the proliferation of breast cancer cells, upregulated FERRE contributed to cell proliferation of MCF-7. Transwell assay showed that FERRE was associated with the migration ability of tumor cells, increased expression of FERRE promoted the migration and invasion of breast cancer cells. 33215433 FER1L4 LncRNA Homo sapiens Stomach Neoplasms cell line regulation[ Hippo-YAP signaling pathway] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay Results indicated that the expression level of FER1L4 was distinctly decreased in GC cells, as evidenced by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis.Taken together, these results demonstrated that lncRNA FER1L4 suppressed cell proliferation, invasion, migration and lymphatic metastasis of GC cells by inactivation of the Hippo-YAP pathway, providing novel insights into regulatory mechanism under GC and new strategies for clinical practice. Yes By using cell proliferation assay, Transwell assay, wound healing assay and western blotting, we found out that overexpression of FER1L4 in SGC-7901 cells hindered the capacities of cell proliferation, invasion, migration and lymphatic metastasis. 33042432 FER1L4 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Regulation[PI3K/AKT signaling pathway] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay In the present study, it was demonstrated that the expression level of FER1L4 was significantly decreased in clinical lung cancer tissues and in cultured lung cancer cells, as evidenced by reverse transcription‑quantitative polymerase chain reaction analysis. Overexpression of FER1L4 led to a reduction in the expression levels of phosphoinositide 3‑kinase (PI3K)/protein kinase B (Akt) in A549 and 95D cells, whereas, activation of PI3K/Akt signaling using a small molecular inhibitor of phosphatase and tensin homolog, reversed the inhibitory effects of FER1L4 on cell proliferation and metastasis. Yes Overexpression of FER1L4 in lung cancer cell lines A549 and 95D inhibited colony formation, cell proliferation and cell migration capacity, measured by colony formation assays, cell proliferation assays and Transwell assays, respectively. 31115514 FER1L4 LncRNA Homo sapiens Lung Neoplasms NSCLC tissues and cell lines,blood regulation[PTEN/AKT/p53 signaling pathway ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay The results revealed that FER1L4 was significantly downregulated in NSCLC plasma and tissues and lung cancer cell lines compared to corresponding controls.The present study indicated that FER1L4 may inhibit cell proliferation and promote apoptosis of NSCLC cells via the PTEN/AKT/p53 pathway, which provides a better understanding of the pathogenesis of NSCLC and may provide a novel potential therapeutic target for clinical treatment. Yes Moreover, a significant decrease of cell proliferation, migration and invasion were observed in FER1L4?overexpressed cells. 33416121 FER1L4 LncRNA Homo sapiens Colorectal Neoplasms cancer cells Interaction(miR-1273g-3p/PTEN ) ISH//Tunel//CCK8//qRT-PCR//ChIP FER1L4 sponged the expression of miR-1273g-3p, which, in turn, increased PTEN expression, leading to cell-cycle arrest. Yes Both FER1L4 and p73 knockdown enhanced the migration and invasion rate of colorectal cancer cells. FER1L4 also plays a critical role in p73-mediated cell-cycle arrest and apoptosis. 35198876 FER1L4 LncRNA Homo sapiens Osteoarthritis plasma and synovial fluid Regulation(IL-6 ) qRT-PCR//MTT//Luciferase Report Assay//Western Blot Our data showed that whereas lncRNA FER1L4 is downregulated in OA patients, IL-6 is upregulated. The plasma FER1L4 levels among the OA cases were suppressed with disease progression and old age, and the down-regulation could efficiently discriminate OA patients from normal subjects. Taken together, our data demonstrates that FER1L4 could efficiently identify OA cases from normal subjects, and can also modulate the expression of IL-6 in human chondrocytes. The plasma FER1L4 levels among the OA cases were suppressed with disease progression and old age, and the down-regulation could efficiently discriminate OA patients from normal subjects. Yes In addition, upregulation of FER1L4 inhibited IL-6 expression in human chondrocyte cells, and treatment with different concentrations of exogenous IL-6 did not affect the expression of FER1L4. 34158566 FENDRR LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cells Expression[lower expressed] RNA Pull-Down//ChIP//Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay The results showed that lncRNA FENDRR was downregulated in CCA tissues and cells, and was negatively correlated with survivin expression. Yes Further investigation demonstrated that FENDRR represses CCA cell proliferation, migration and invasion through regulating survivin expression. 30983519 FENDRR LncRNA Homo sapiens Melanoma MM tissues and cell lines regulation[ JNK/c-Jun pathway] qRT-PCR//MTT//Western Blot//Transwell Assay FENDRR was down-regulated in MM tissues and cell lines.Our results demonstrated that FENDRR mediated the metastasis phenotype of MM cells by inhibiting the expressions of MMP2 and MMP9 and antagonizing the JNK/c-Jun pathway. Yes Knockdown of FENDRR facilitated MM cells proliferation, migration and invasion in A375 cells, while overexpressing FENDRR had reverse results. 32134466 FENDRR LncRNA Homo sapiens endometrial endometrioid adenocarcinoma, secretory variant cancerous tissues Regulation(SOX4 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//MeRIP//qRT-PCR//RIP//Cell Apoptosis Assay//Cell Proliferation Assay The expression level of LncRNA FENDRR was decreased and the N-methyladenosine (m6A) methylation levels of LncRNA FENDRR was elevated in cancerous tissues of EEC patients. LncRNA FENDRR overexpression suppressed cell proliferation and facilitated cell apoptosis in the EEC cell line HEC-1B by reducing the protein level of SRY-related HMG box transcription factor 4 (SOX4).Interference of LncRNA FENDRR reversed the inhibitory effect of sh-YTHDF2 on cell proliferation and the promoting effect of sh-YTHDF2 on cell apoptosis in HEC-1B cells by silencing FENDRR. Yes In vitro experiments demonstrated that YTH domain-containing 2 (YTHDF2), an m6A reader, recognized the abundance of m6A-modified LncRNA FENDRR in EEC cells and promoted its degradation.Finally, in vivo experiments confirmed that overexpression of LncRNA FENDRR retarded the growth of EEC cells. 33692441 Fendrr LncRNA Rattus norvegicus Pancreatitis pancreatic tissues Interaction(PRC2/ATG7) In Vivo Experiment//ChIP//Western Blot//Transfection//Tunel//qRT-PCR//RIP//Cell Apoptosis Assay//H&E Staining//ELISA//IHC//IF Higher FENDRR and impaired autophagy were displayed in both AP mouse models and cell models. FENDRR knockdown dramatically attenuated caerulein- or TLC-S-induced AR42J cells apoptosis and autophagy suppression. Further mechanistic experiments implied that the action of FENDRR is moderately attributable to its repression of ATG7 via direct interaction with the epigenetic repressor PRC2. Moreover, the silencing of FENDRR significantly induced the promotion of ATG7, thus alleviating the development of AP in vivo. Yes FENDRR knockdown dramatically attenuated caerulein- or TLC-S-induced AR42J cells apoptosis and autophagy suppression.Moreover, the silencing of FENDRR significantly induced the promotion of ATG7, thus alleviating the development of AP in vivo. 33417179 FAM83A-AS1 LncRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues and cell lines interaction[binding to miR-495-3p] qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Transwell Assay It was found that FAM83A-AS1 was upregulated in esophageal cancer tissues and cell lines. FAM83A-AS1 is upregulated in esophageal cancer, and it stimulates migratory potential in esophageal cancer by negatively regulating miR-495-3p. Higher rates of lymphatic and distant metastasis and worse survival were observed in esophageal cancer patients expressing higher level of FAM83A-AS1. Yes Besides, the knockdown of FAM83A-AS1 suppressed migratory potential in OE19 cells, while the overexpression of FAM83A-AS1 yielded the opposite trend in OE33 cells. 33015782 FAM83A-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Regulation[FAM83A-AS1/miR-150-5p/MMP14 axis] Western Blot//Wound Healing Assay//qRT-PCR//RIP//FISH//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this study, we found FAM83A-AS1 to be upregulated in LUAD tissues and closely associated with tumor size, lymph node metastasis, and TNM stage.Collectively, we conclude that the novel FAM83A-AS1/miR-150-5p/MMP14 axis regulates LUAD progression, suggesting an innovative therapeutic strategy for this cancer. In this study, we found FAM83A-AS1 to be upregulated in LUAD tissues and closely associated with tumor size, lymph node metastasis, and TNM stage. In addition, high FAM83A-AS1 expression correlated positively with a poor prognosis. Yes Functional investigation revealed that FAM83A-AS1 promotes LUAD cell proliferation, migration, invasion and the epithelial-mesenchymal transition (EMT) in vitro and tumor growth in vivo. 31522616 FAM83A-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues Regulation(FAM83A ) RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Invasion Assay//Transwell Assay High expression of FAM83A-AS1 in lung adenocarcinoma (LUAD) was closely associated with low overall survival (OS) and progression-free survival (PFS).Furthermore, FAM83A-AS1 promoted NSCLC progression via ERK signaling pathways. Mechanistically, FAM83A-AS1 post-transcriptionally increased FAM83A expression by enhancing pre-mRNA stability. High expression of FAM83A-AS1 in lung adenocarcinoma (LUAD) was closely associated with low overall survival (OS) and progression-free survival (PFS). Yes Functionally, high FAM83A-AS1 expression increased LUAD cell proliferation and metastasis, indicating that FAM83A-AS1 exerted its oncogenic functions. 33687144 FAM83A-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction(miR-495-3p/FAM83A ) Western Blot//Bioinformatics Analysis//Transfection//Invasion Assay//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining FAM83A and FAM83A-AS1 were both overexpressed in LUAD tissues compared with adjacent normal tissues. Moreover, lncRNA FAM83A-AS1 regulated the expression of FAM83A by functioning as competing endogenous RNA for miR-495-3p. These results implicated that FAM83A and FAM83A-AS1 both played oncogenic roles in LUAD and FAM83A-AS1 could regulate the expression of FAM83A by sponging miR-495-3p. High expression of FAM83A and FAM83A-AS1 predicted worse survival and more advanced clinical stage. Yes Knockdown of FAM83A or FAM83A-AS1 could inhibit the proliferation, migration and invasion of LUAD cells. 33732373 FAM83A-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung lung cancer cells and tissue samples Interaction(miR-141-3p) Western Blot//Bioinformatics Analysis//Invasion Assay//Migration Assay//CCK8//qRT-PCR//IF//Luciferase Report Assay//Cell Proliferation Assay//EdU Staining//Transwell Assay FAM83A-AS1 expression was remarkably raised in lung cancer cells and tissue samples; however, miR-141-3p level markedly reduced relative to healthy samples. According to our results, FAM83A-AS1/miR-141-3p axis plays an important role in LUAD occurrence and development. Yes FAM83A-AS1 silencing suppressed EMT, growth, invasion and migration of LUAD cells. 35164653 FAM83A-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cells Interaction(HIF-1α/ glycolysis axis) Western Blot//Co-IP//Migration Assay//CCK8//qRT-PCR//Invasion Assay Besides, we revealed that FAM83A-AS1 could affect glycolysis by regulating HIF-1α degradation. Finally, we found that FAM83A-AS1 knockdown could inhibit tumor growth and suppress the expression of HIF-1α and glycolysis-related genes in vivo. Yes In addition, we uncovered that FAM83A-AS1 could promote the migration and invasion of LUAD cells, as well as influence the stemness of LUAD cells in vivo and vitro. Moreover, FAM83A-AS1 was shown to promote glycolysis in LUAD cell lines in vitro and in vivo, and was found to influence the expression of genes related to glucose metabolism. 35002507 FAM83A-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung lung cancer tissues Regulation(AMPKα and ULK1 ) Western Blot//Flow Cytometry//qRT-PCR//RNA-seq//Cell Proliferation Assay//Colony Formation Assay We found that FAM83A-AS1 was up-regulated in lung cancer and elevated expression was associated with poor patient survival. Mechanistically, serval oncogenic proteins such as EGFR, MET, PI3K, and K-RAS were decreased upon FAM83A-AS1 silencing, while phosphor AMPKα and ULK1 were increased. We found that FAM83A-AS1 was up-regulated in lung cancer and elevated expression was associated with poor patient survival. Yes Functional study indicated that FAM83A-AS1 knockdown reduced cell proliferation, migration, invasion, and colony formation in cancer cells. FAM83A-AS1 silencing induced autophagy and cell cycle arrest at G2. 35635086 FAM83A-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction(miR-214/CDC25B axis) Transfection//Flow Cytometry//qRT-PCR//Cell Proliferation Assay//Transwell Assay Here, we discovered that FAM83A-AS1 was strongly expressed in ESCC tissues. Mechanistically, we found that FAM83A-AS1 regulated miR-214 expression, and there was a negative correlation between miR-214 and FAM83A-AS1 in ESCC. Rescue assay indicated that miR-214 could impair the suppressing effect of cell migration induced by FAM83A-AS1 depletion.Furthermore, CDC25B was a direct target of miR-214, and FAM83A-AS1 enhanced CDC25B expression while miR-214 positively CDC25B expression in ESCC. FAM83A-AS1 abundance was associated with TNM stages and the differentiation grade of ESCC patients. Yes Functionally, inhibiting FAM83A-AS1 repressed cell proliferation, migration, and invasion in ESCC. In addition, we found that FAM83A-AS1 accelerated the cell cycle while inhibited cell apoptosis. 33442418 FAM66C LncRNA Homo sapiens Prostatic Neoplasms prostate cancer cells Expression[highly expressed] qRT-PCR Real-time PCR showed that FAM66C highly expressed in prostate cancer cells, and knockdown FAM66C by siRNAs resulted in significant inhibition of cell growth. Yes Real-time PCR showed that FAM66C highly expressed in prostate cancer cells, and knockdown FAM66C by siRNAs resulted in significant inhibition of cell growth. 32430927 FAM66C LncRNA Homo sapiens Cholangiocarcinoma ICC tissues and cells Interaction(hsa-miR-23b-3p/KCND2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay FAM66C was increased in ICC tissues and cells, increased cell viability, glycolysis, migration and invasion, and decreased apoptosis were shown in FAM66C overexpressing cells.Mechanistic analyses revealed that FAM66C regulated the downstream target gene KCND2 by sponging miR-23b-3p. These data revealed that FAM66C was able to drive ICC tumor progression and glycolytic activity via the miR-23b-3p/KCND2 axis, indicating FAM66C may be a viable target for treating ICC. Yes FAM66C was increased in ICC tissues and cells, increased cell viability, glycolysis, migration and invasion, and decreased apoptosis were shown in FAM66C overexpressing cells. FAM66C effect on ICC was further validated in murine xenograft assays. 34418280 FAM3D-AS1 LncRNA Homo sapiens Colorectal Neoplasms cell lines Regulation[NF-κB signaling pathway] CCK8//qRT-PCR//Transwell Assay//Western Blot The expression of FAM3D-AS1 was significantly decreased in colorectal cells (Figure 1B). Moreover, we proved that FAM3D-AS1 inhibits CRC development through NF-κB signaling pathway. Yes Overexpression of FAM3D-AS1 significantly inhibited the cell proliferation, cell survival rates, and invaded cells. 31147452 FAM30A LncRNA Homo sapiens Colorectal Neoplasms colorectal tissues and cells Interaction[Wnt/β-catenin pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay In this study, we found that lncRNA KIAA0125 was downregulated in colorectal tissues and cells. Besides, KIAA0125 inhibited epithelial-mesenchymal transition through Wnt/β-catenin signaling in CRC. Our findings suggested that KIAA0125 may act as an oncosupressor gene and could be considered as a potential diagnosis biomarker in CRC. Yes The functional study demonstrated that overexpression of KIAA0125 suppressed cell proliferation, migration, and invasion whereas the reversal effects were seen in silencing experiment. 31228314 FAM238C LncRNA Homo sapiens Retinoblastoma RB tissues Interaction[Sponging miR-3619-5p ] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay LINC00202 expression in RB tissues is higher than that in the paired adjacent normal tissues, which has correlation with poor prognosis in RB. In summary, high LINC00202 levels are correlated with poor prognosis in RB, and it promotes RB progression by sponging miR-3619-5p and therefore up-regulating RIN1 expression.Key words: LINC00202, miR-3619-5p, retinoblastoma, progression, RIN1. Yes RB cell proliferation, migration and invasion were weakened by LINC00202 depletion, but enhanced by LINC00202 overexpression. 30905893 FAM238C LncRNA Homo sapiens Retinoblastoma RB tumor tissues regulation[miR-204-5p/HMGCR axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay LINC00202 expression was upregulated in RB tumor tissues and LINC00202 knockdown inhibited RB cell proliferation, glycolysis, and stimulated apoptosis in vitro as well as impeded tumor growth in vivo. In all, LINC00202 promoted RB cell proliferation, glycolysis, and suppressed apoptosis by regulating the miR-204-5p/HMGCR axis, suggesting a novel therapeutic target for patients with RB. Yes LINC00202 expression was upregulated in RB tumor tissues and LINC00202 knockdown inhibited RB cell proliferation, glycolysis, and stimulated apoptosis in vitro as well as impeded tumor growth in vivo. 33817232 FAM230B LncRNA Homo sapiens Stomach Neoplasms gastric cancer cell lines regulation[miR-27a-5p/TOP2A Axis] qRT-PCR//Luciferase Report Assay We found that FAM230B was highly expressed in gastric cancer cell lines and mainly located in the cytoplasm. Our study showed that lncRNA FAM230B might function to promote GC. FAM230B functioned as a ceRNA by sponging miR-27a-5p and enhancing TOP2A expression. Yes FAM230B overexpression promoted the proliferation, migration, and invasion of AGS cells and repressed their apoptosis; it also facilitated tumor growth in vivo.In contrast, FAM230B knockdown suppressed the proliferation, migration, and invasion of MGC0803 cells, but enhanced their apoptosis and inhibited tumor growth in vivo. 32910366 FAM230B LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-1182) qRT-PCR//MTT//Colony Formation Assay//Western Blot We found that FAM230B and premature miR-1182 were highly upregulated in CRC, while mature miR-1182 was downregulated in CRC.FAM230B was detected in both nucleus and cytoplasm, and it directly interacted with miR-1182. Yes FAM230B overexpression increased the expression levels of premature miR-1182 but decreased the expression levels of mature miR-1182 in CRC cells. FAM230B promoted CRC cell proliferation, increased cell viability, accelerated colony formation, and suppressed the role of miR-1182 in inhibiting CRC cell proliferation. 36262247 FAM230B LncRNA Homo sapiens Osteosarcoma OS cells Interaction(miR-203) qRT-PCR FAM230B and premature miR-203 were upregulated in OS, whereas mature miR-203 was downregulated in OS cells. FAM230B was detected in the cytoplasm and directly interacted with premature miR-203. FAM230B overexpression in OS cells increased premature miR-203 level and decreased mature miR-203 level. Yes FAM230B increased cell proliferation and suppressed the role of miR-203 in inhibiting cell proliferation. FAM230B in the cytoplasm may sponge premature miR-203, thereby inhibiting miR-203 maturation to increase OS cell proliferation. 35377981 FAM230B LncRNA Homo sapiens Osteosarcoma OS cells and tissues Interaction(miR-302b ) qRT-PCR//RNA Pull-Down Increased FAM230B and premature miR-302b and decreased mature miR-302b were observed in OS. FAM230B was detected in both nuclear and cytoplasm samples and directly interacted with premature miR-302b.FAM230B overexpression in OS cells 143B and HOS decreased miR-302b maturation and increased cell invasion and migration, while miR-302b overexpression suppressed cell invasion and migration. FAM230B silencing restrained cell invasion and migration, and miR-302b inhibitor accelerated cell invasion and migration. MiR-302b knockdown significantly reversed the suppressive effects of shFAM230B on migration and invasion of 143B and HOS cells. Yes FAM230B overexpression in OS cells 143B and HOS decreased miR-302b maturation and increased cell invasion and migration, while miR-302b overexpression suppressed cell invasion and migration. FAM230B silencing restrained cell invasion and migration, and miR-302b inhibitor accelerated cell invasion and migration. MiR-302b knockdown significantly reversed the suppressive effects of shFAM230B on migration and invasion of 143B and HOS cells. 35639175 FAM83A-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction[binding with NOP58 ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//FISH//Colony Formation Assay//Transwell Assay In the present study, we found the abundantly increased expression level of FAM83A-AS1 in HCC tissues and cells. In conclusion, FAM83A-AS1 facilitated HCC progression by binding with NOP58 to enhance the stability of FAM83A. These findings offer a novel biological insight into HCC treatment. Yes FAM83A-AS1 inhibition hampered cell proliferation, migration and elevated cell apoptosis in HCC. 31696213 FAM83A-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissue Interaction[increasing FAM83A ] CCK8//qRT-PCR//Migration Assay//Western Blot We then proceeded to validate the expression levels of these 10 NATs in 10 paired normal tissues and cancer tissues from patients with NSCLC by qRT‐PCR analyses. The results showed that seven NATs were significantly upregulated in these patients, particularly FAM83A‐AS1 (Figure ​(Figure2B).2B). Because FAM83A‐AS1 was the most overexpressed AS in cancer tissues (Figure ​(Figure2B),2B), we chose FAM83A‐AS1 for further studies.In summary, lncRNA FAM83A-AS1 promotes LUAD by increasing FAM83A expression. Yes Finally, overexpression of FAM83A-AS1 promoted LUAD cell proliferation and invasion. 30659636 FAM83A-AS2 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Expression(highly expressed) qRT-PCR AC068228.1 expression was significantly elevated in LUAD tissues compared with normal tissues. GSEA and infiltration analysis confirmed that AC068228.1 expression was significantly correlated with immune cells infiltrating in LUAD. Higher expression of AC068228.1 was strongly correlated with adverse clinical outcomes and was identified as an independent prognostic marker for LUAD patients. Yes Knockdown of AC068228.1 inhibited the cell proliferation and cell migration of LUAD. 35280807 FAUP4 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-6760-5p, miR-6512-3p, miR-1298-5p, miR-6720-5p, miR-4516, and miR-6782-5p/HOTTIP ) qRT-PCR PAARH functioned as a competing endogenous RNA to upregulate HOTTIP via sponging miR-6760-5p, miR-6512-3p, miR-1298-5p, miR-6720-5p, miR-4516, and miR-6782-5p. The expression of PAARH was significantly positively associated with HOTTIP in HCC tissues. Yes Gain- and loss-of function assays revealed that PAARH facilitated HCC cellular growth, migration, and invasion, repressed HCC cellular apoptosis, and promoted HCC tumor growth and angiogenesis in vivo. 35110549 FBXL19‑AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction( miR-431/PBOV1 axis) Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay It was demonstrated that the expression levels of FBXL19‑AS1 and PBOV1 were upregulated in NPC tissues and cells, whereas miR‑431 expression was downregulated. FBXL19‑AS1 directly interacted with miR‑431. miR‑431 could target the 3'‑untranslated region of PBOV1. Overexpression of PBOV1 neutralized the miR‑431‑mediated suppression of NPC progression. Moreover, FBXL19‑AS1 could regulate PBOV1 by sponging miR‑431 in NPC cells. I Yes FBXL19‑AS1 silencing inhibited the viability, migration and invasion of C666‑1 and SUNE1 cells, whereas these effects could be alleviated by suppressing miR‑431. 34278444 FBXL19-AS1 LncRNA Homo sapiens Breast Neoplasms cell lines Regulation[miR-876-5p/FOXM1 axis] CCK8//qRT-PCR//Luciferase Report Assay//RIP FBXL19-AS1 was expressed at a high level in breast cancer cells. In addition, the location of FBXL19-AS1 in the cytoplasm was detected by fluorescent in situ hybridization assay, while FBXL19-AS1 regulated the expression of Forkhead box M1 (FOXM1) by directly absorbing miR-876-5p. Through rescue assays, it was observed that FOXM1 overexpression recovered the inhibited tumor growth caused by FBXL19-AS1 downregulation. We affirmed the function of FBXL19-AS1 in breast cancer and described the mechanism of the FBXL19-AS1/miR-876-5p/FOXM1 axis. The current work presents the molecular mechanism which underlies FBXL19-AS1 in breast cancer and suggests a comprehensive, feasible FBXL19-AS1-mediated therapeutic approach for treating breast cancer. Yes Loss-of-function experiments revealed that silencing FBXL19-AS1 could impair cell proliferation and induce cell apoptosis in breast cancer. 31696201 FBXL19-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Expression[highly expressed] Western Blot//Flow Cytometry//qRT-PCR//Colony Formation Assay//Transwell Assay The results of qRT-PCR showed that the expression of lncRNA FBXL19-AS1 in NSCLC tissues and cells was up-regulated. Yes According to the results of the colony formation assay, the proliferative capacity of NSCLC cells was decreased after the interference with lncRNA FBXL19-AS1 expression. In flow cytometry, it was indicated that the cell cycle was arrested at the G0/G1 phase in the experimental group compared with that in the control group. The transwell assay results showed that the migratory and invasive abilities of NSCLC cells were weakened after the interference with lncRNA FBXL19-AS1 expression. 31210311 FBXL19-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell lines Regulation[miR-431-5p/RAF1 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, we found that FBXL19-AS1 expression was up-regulated in lung cancer tissues and cell lines.Together, these results indicated that FBXL19-AS1 was involved in progression and angiogenesis in lung cancer by targeting miR-431-5p/RAF1 axis, which provided a new insight into the therapeutic strategies of lung cancer. Yes FBXL19-AS1 knockdown inhibited cell proliferation, migration, invasion, and angiogenesis in lung cancer cells. 30610161 FBXL19-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines interaction[miR-346] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We first showed that lncRNA FBXL19-AS1 was upregulated in OS tissues and cell lines. Furthermore, we proved that miR-346 could directly target FBXL19-AS1 through luciferase assays, suggesting FBXL19-AS1 could sponge miR-346. Yes In vitro experiments showed that FBXL19-AS1 promoted OS cell proliferation, migration, and invasion. 30555237 FBXL19-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Interaction( miR-193a-5p/COL1A1.) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay FBXL19-AS1 and COL1A1 were significantly up-regulated in CC tissues, while miR-193a-5p was significantly down-regulated. Mechanistically, FBXL19-AS1 functioned as a competitive endogenous RNA (ceRNA) and inhibited the expression of miR-193a-5p, which targeted at the 3'-UTR site of COL1A1 and negatively regulated COL1A1 expression. Yes Overexpression of FBXL19-AS1 significantly promoted the proliferation, migration, invasion, EMT and growth of CC cells and inhibited apoptosis, while knockdown of FBXL19-AS1 had the opposite effects. On the other hand, miR-193a-5p inhibited the proliferation and metastasis of CC cells. 34399848 FBXL19-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction[sponging miR-203a-3p] qRT-PCR In this study, we observed that FBXL19-AS1 was significantly upregulated in LUAD tissues and high FBXL19-AS1 expression in LUAD was associated with a poor prognosis. Mechanistically, we identified FBXL19-AS1 could act as a miR-203a-3p sponge using dual-luciferase reporter assay. Yes Moreover, cell viability and apoptosis analysis revealed that FBXL19-AS1 knockdown could arrest LUAD cells in G0/G1 phase and inhibit cell proliferation, migration and invasion in vitro and inhibited LUAD tumor progress in vivo. 31566718 FBXL19-AS1 LncRNA Homo sapiens Liver Neoplasms HCC tissues Interaction(KLF2) Western Blot//Transfection//CCK8//qRT-PCR//RIP//Cell Cycle Assay//EdU Staining//ChIP FBXL19-AS1 was highly expressed in HCC tissues, especially in those larger than 5 cm in tumor size and worse tumor stage. FBXL19-AS1 was mainly distributed in nucleus and interacted with EZH2 and SUZ12. FBXL19-AS1 was highly expressed in HCC tissues, especially in those larger than 5 cm in tumor size and worse tumor stage. Yes Knockdown of FBXL19-AS1 suppressed proliferation, cell cycle progression and induced apoptosis of HCC cells. Moreover, silence of FBXL19-AS1 attenuated the recruitment ability of EZH2 on KLF2. 34564989 FAT1 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma tumor tissue Interaction(miR-548g) qRT-PCR//RIP//PCR//IP//Invasion Assay CircFAT1 expression levels were significantly lower in tumor tissue than in adjacent non-tumorous mucosal tissue (p = 0.01). The expression of miR-548g was upregulated by the downregulation of circFAT1. The overexpression of miR-548g also promoted ESCC cell migration and invasion. Recurrence-free survival (p = 0.02) and cancer-specific survival (p = 0.04) rates were significantly higher in patients with elevated circFAT1 expression levels. Yes The downregulation of circFAT1 expression promoted ESCC cell migration and invasive ability, but not proliferation. 34185205 FAM83C-AS1 LncRNA Homo sapiens Colorectal Neoplasms tumor tissues regulation[SEMA3F ,EZH2] qRT-PCR FAM83C-AS1 is upregulated in tumor tissues and cells of CRC, which is negatively correlated with SEMA3F expression.Our data thus demonstrate that the epigenetic role of FAM83C-AS1 in suppression of SEMA3F expression through stabilization of EZH2 to drive CRC progression, which may be conducive to discovering novel therapeutic targets for the treatment of CRC. Yes Reciprocally, knockdown of FAM83C-AS1 exhibits inhibitory effects on the malignant transformation of CRC. 33109776 FAS-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells regulation[regulating miR-19a-5p] qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay FAS-AS1 was remarkably down-regulated in NSCLC cells.FAS-AS1 suppressed cell proliferation, migration, and invasion by sponging miR-19a-5p in NSCLC, indicating that FAS-AS1 might be a potential biomarker and therapeutic target for NSCLC. Yes FAS-AS1 inhibited cell proliferation, migration, and invasion in NSCLC cells. 32329854 FARSA CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-330-5p/LASP1 axis] colony Formation Assay//Western Blot//qPCR//PCR//Colony Formation Assay//IF circ-FARSA was upregulated in CRC tissues and cell lines, and its expression had a significant association with the overall survival of CRC patients.Silencing of circ-FARSA restricted the growth of CRC through regulating the miR-330-5p/LASP1 axis, providing a novel regulatory mechanism for CRC tumorigenesis. circ-FARSA was upregulated in CRC tissues and cell lines, and its expression had a significant association with the overall survival of CRC patients. Yes Knockdown of circ-FARSA inhibited the proliferation, migration, and invasion of CRC cells in vitro. 32473899 FAM99B LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR FAM99B was found to be downregulated in HCC tissues compared with adjacent normal tissues based on TCGA, GEO, and qRT-PCR data. Our results revealed that downregulated FAM99B was significantly associated with vascular invasion, advanced histologic grade, and T stage. Kaplan-Meier analysis using TCGA data indicated that decreased FAM99B levels were significantly associated with poor overall survival in patients with HCC. Yes HCC. Moreover, overexpression of FAM99B significantly inhibited cell proliferation, migration, and invasion in vitro. 31243545 FAM99A LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Expression(lower expressed) qRT-PCR The three public online databases and qRT-PCR data showed that FAM99A was frequently downregulated in HCC tissues and inversely correlated with microvascular invasion and advanced histological grade of HCC patients. A subcutaneous xenograft tumor model demonstrated that overexpression of FAM99A significantly inhibited the tumor growth of HCC cells in vivo. Seven tumor-related proteins (PCBP1, SRSF5, SRSF6, YBX1, IGF2BP2, HNRNPK, and HNRNPL) were recognized as possible FAM99A-binding proteins by the RNA pull-down and mass spectrometry assays. Kaplan-Meier survival analysis indicated that decreased FAM99A was significantly associated with poor overall survival of HCC patients based on TCGA database (P = 0.040), ICGC data portal (P < 0.001), and our HCC cohort (P = 0.010). Yes Upregulation of FAM99A suppressed the proliferation, colony formation, migration, and invasion capacities of HCC cells in vitro, and knockdown of FAM99A had the opposite effects. 36289466 FAM88C LncRNA Homo sapiens Pterygium pterygium tissues Interaction( PI3K/PDK1 pathway and Akt/mTOR signaling pathway ) Western Blot//IF//migration assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Notably, we identified a novel lncRNA, LOC102724238, which we named pterygium positively-related lncRNA (lnc-PPRL), was up-regulated in pterygium. Further study of underlying mechanisms demonstrated that lnc-PPRL may exert its biological effect by activating canonical PI3K/PDK1 pathway, and subsequently promoting the activation of Akt/mTOR signaling pathway and its downstream effectors.Interestingly, lnc-PPRL was also proved to influence YAP nuclear localization. Yes Lnc-PPRL showed to be preferentially accumulated in cytoplasm, and it can promote cell proliferation, migration and invasion of human pterygium epithelium cells (hPECs). 35304111 FAM87A LncRNA Homo sapiens Glioma glioma tissue and cells Interaction( miR-424-5p/PPM1H ) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//FISH//MTT//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay qRT-PCR result indicated that FAM87A was abnormally downregulated in glioma tissue and cells. Results of bioinformatics, dual luciferase, and RIP assays unveiled that FAM87A and miR-424-5p act upon each other. In addition, miR-424-5p targeted 3'-UTR of PPM1H. Also, effects of miR-424-5p/FAM87A on glioma cells were identified via the cell function experiments. FAM87A suppressed PPM1H by binding to miR-424-5p. Survival analysis suggested that the FAM87A expression was negatively correlated with the survival rate. Yes Effects of FAM87A on human glioma cell lines were also analyzed by MTT, Edu, and transwell assays. FAM87A hastened proliferation and migration of glioma cells. 34712356 FAM84B-AS LncRNA Homo sapiens Stomach Neoplasms cell lines Expression[highly expressed] CCK8//qRT-PCR//Western Blot//Microarray Next, FAM84B-AS expression was detected in gastric cancer cell lines. FAM84B-AS exhibited high expression in AGS and MKN45(Fig. 2A). Expression[up-expression] Yes FAM84B-AS interference significantly inhibited the proliferation and invasion abilities of gastric cancer cells and significantly increased the percentage of apoptosis. 30638658 FAM83H LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell line Interaction(miR-545-3p/HS6ST2 axis) CCK8//qRT-PCR The results revealed that FAM83H-AS1 is highly expressed in lung cancer tissues, and its knockdown inhibits lung cancer cell invasion and proliferation reducing tumor growth in vivo. Besides, we found that FAM83H-AS1 targets miR-545-3p, and a negative correlation exists between their expression in lung cancer tissues. Simultaneously, miR-545-3p negatively regulates heparan sulfate 6-O-sulfotransferase (HS6ST2). Moreover, inhibition of miR-545-3p promoted HS6ST2 protein expression and lung cancer cell invasion. FAM83H-AS1 favors non-small cell lung cancer by targeting the miR-545-3p/HS6ST2 axis, supporting the possibility of developing FAM83H-AS1 as a target for NSCLC intervention. Yes The results revealed that FAM83H-AS1 is highly expressed in lung cancer tissues, and its knockdown inhibits lung cancer cell invasion and proliferation reducing tumor growth in vivo. 35260044 GACAT3 LncRNA Homo sapiens Osteoarthritis osteoarthritis synoviocytes Expression[IL-6/STAT3 signaling pathway] qRT-PCR We found that GACAT3 expression was significantly increased in OAS compared with NS.Moreover, GACAT3 could impact the proliferation of OAS by interleukin-6/signal transducer and activator of transcription-3 (IL-6/STAT3) signaling pathway. Yes GACAT3 expression was decreased in OAS after transfection with siRNA and the cell proliferation in OAS after transfection with siRNA was significantly inhibited. The cell cycle was arrested in G0/G1 phase and the apoptosis rate was increased in OAS after transfection with siRNA. 30178830 GACAT3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissue and cell specimens Interaction(miR-149/FOXM1) CCK8//qRT-PCR GACAT3 amounts were elevated in ESCC tissue and cell specimens. Furthermore, GACAT could directly interact with miR-149. In addition, colony formation and invasion assays verified that GACAT3 promotes ESCC tumor progression through miR-149. Moreover, GACAT3 acted as a competing endogenous RNA (ceRNA) to modulate FOXM1 expression. Yes Functional studies showed that GACAT3 silencing reduced the proliferation, migration and invasion of cultured ESCC cells, and decreased tumor growth in mice. 34496842 H19 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues and adjacent tissues Interaction[CDH1] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//ChIP The results exhibited that compared with the adjacent tissues, the expression of lncRNA H19 was significantly elevated and the mRNA expression of CDH1 was notably decreased in the lung adenocarcinoma tissues Yes A549 cells with silencing of lncRNA H19, overexpression of CDH1 or reduced CDH1 methylation by demethylating agent 5-Az had sExpression[Expression[up-expression]-expression]pressed cell proliferation, sphere-forming ability, apoptosis, migration and invasion, in addition to inhibited EMT process. Silencing lncRNA H19 could reduce methylation level of CDH1. In vivo, A549 cells with silencing lncRNA H19, overexpression of CDH1 or reduced CDH1 methylation exhibited low tumorigenicity, reflected by the smaller tumour size and lighter tumour weight. Taken together, this study demonstrates that silencing of lncRNA H19 inhibits EMT and proliferation while promoting apoptosis of lung adenocarcinoma cells by inhibiting methylation of CDH1 promoter. 31317666 H19 LncRNA Homo sapiens Endometriosis endometriosis Interaction[targeting ITGB3 via modulating miR-124-3p] cell invasion assay//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay We found that ectopic endometrial cells taken from women with endometriosis showed elevated levels of lncRNA-H19, with expression levels correlating to disease progression.Coinciding with this change was an increase in microRNA-124-3p (miR-124-3p) and a decrease in integrin beta-3 (ITGB3) levels. The addition of a miR-124-3p inhibitor mitigated this decrease in ITGB3. Up-regulation of miR-124-3p markedly suppressed ITGB3 expression by binding to the 3' untranslated region (3' UTR), while inhibition of miR-124-3p had the opposite effect. ITGB3 overexpression potently counteracted the effects of miR-124-3p mimics on ectopic endometrial cells. Yes Knockdown of H19 in ectopic endometrial cells inhibited cell proliferation and invasion. 31085188 H19 LncRNA Homo sapiens Stroke blood Regulation[H19-miR-19a-Id2 axis] RNA Pull-Down//Western Blot//Transfection//Tunel//Flow Cytometry//RIP//qRT-PCR//Luciferase Report Assay This study found that H19 levels were elevated in the serum of stroke patients, as well as in the ischemic penumbra of rats with middle cerebral artery occlusion/reperfusion (MCAO/R) injury and neuronal cells with oxygen glucose deprivation (OGD). Lastly, with gain and loss of function studies, dual luciferase reported assay, RNA immunoprecipitation (RIP) and pull-down experiments, we demonstrated the dual competitive interaction of miR-19a with H19 and the 3'-UTR of Id2 mRNA, resulting in the identification of the H19-miR-19a-Id2 axis. With biological studies, we also revealed that H19-miR-19a-Id2 axis modulated hypoxia induced neuronal apoptosis. This study demonstrates that the identified H19-miR-19a-Id2 axis plays a critical role in hypoxia induced neuronal apoptosis, and blocking this axis may serve as a novel therapeutic strategy for ischemic brain injury. Yes Further, knockdown of H19 with siRNA alleviated cell apoptosis in OGD neuronal cells, and inhibition of H19 in MCAO/R rats significantly decreased neurological deficit, brain infarct volume and neuronal apoptosis. 31170091 H19 LncRNA Homo sapiens Hodgkin Disease HL tissues and cell lines Interaction[AKT pathway] CCK8//qRT-PCR//Western Blot H19 was overexpressed in HL tissues and cell lines compared with those of controls. AKT expression was upregulated in HL tissues compared with RH tissues, and was positively regulated by H19. Western blot results also indicated that H19 overexpression upregulated protein expression of AKT in HL cells. HL patients with huge lump and in Ann Arbor stage III-IV presented higher expression of H19. Besides, H19 expression was negatively correlated to overall survival (OS) of HL patients. Yes In vitro experiments suggested that H19 downregulation decreased proliferation and viability of HL cells. 31128034 H19 LncRNA Homo sapiens Aortic Aneurysm, Abdominal AAA tissues Interaction[H19/let-7a/IL-6] Western Blot//qRT-PCR//Luciferase Report Assay//ELISA//IHC qRT-PCR detected the upregulation of H19 in human and mouse AAA tissue samples.In vivo overexpression of H19 increased vascular inflammation and induced AAA formation, which was supported by exacerbated aortic morphology, maximum aortic diameter values, elastin degradation, expression of interleukin-6 (IL-6) and macrophage chemoattractant protein-1 (MCP-1), and macrophage infiltration. H19 suppression resulted in the opposite effects. A rescue experiment indicated that IL-6 neutralization significantly mitigated the aortic inflammation and AAA formation evoked by H19 overexpression. Luciferase reporter assays and ex vivo experiments using VSMCs and macrophages confirmed that H19 induced aneurysm formation in part via endogenous competition with the let-7a microRNA to induce the transcription of its target gene, IL-6. This mechanism was further validated by in vivo experiments using a mutant H19 that could not effectively bind let-7a. Collectively, our study revealed a pathogenic H19/let-7a/IL-6 inflammatory pathway in AAA formation, which offers a new potential therapeutic strategy for AAA. Yes In vivo overexpression of H19 increased vascular inflammation and induced AAA formation, which was supported by exacerbated aortic morphology, maximum aortic diameter values, elastin degradation, expression of interleukin-6 (IL-6) and macrophage chemoattractant protein-1 (MCP-1), and macrophage infiltration. 30991034 H19 LncRNA Homo sapiens Adrenocortical Carcinoma Expression(lower expressed) qRT-PCR//IF//Western Blot he administration of higher concentration of DACi was able to down-regulate the protein level of Beclin1 and p62 and to induce the conversion of LC3B-I into the active LC3B-II form, thus confirming an active autophagic process. Neither the active protein level nor the activity of caspases 8 and 3 was prompted by the DACi, thus excluding the involvement of the executioners of apoptosis in H295R decay. The DACi restore H19, the autophagy markers and trigger cell death in ACC cells. The re-activation of autophagy would represent a novel strategy for the treatment of patients affected by this severe malignancy. Yes H19 knock down in H295R cells was not able to modulate the expression level of autophagy transcripts. Instead, H19 knock down was able to impede the ability of DACi to modulate the protein level of the autophagy markers. 34726962 H19 LncRNA Homo sapiens Mouth Neoplasms cell lines Regulation[miR-107/CDK6 signaling axis] qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay Compared with that in HIOEC cells, the expression of H19 was significantly increased in CAL27 cells (P<0.05).H19 could bind specifically to the 3'-UTR of miR-107 to modulate the expression of miR-107. Compared with that in HIOEC cells, the expression of miR-107 significantly decreased in CAL27 cells (P<0.05). The expression of miR-107 increased after transfection with siRNA H19, and anti-mir-107 co-transfection could promote the invasion and migration ability of siRNA H19 in CAL27 cells (P<0.05). Compared with that in HIOEC cells, CDK6 expression significantly increased in CAL27 cells (P<0.05), and the expression level of the gene was coregulated by H19 and miR-107 (P<0.05). Yes After transfection with siRNA H19, the expression of H19 decreased, and the invasion and migration ability of CAL27 cells were inhibited (P<0.05). 31512829 H19 LncRNA Homo sapiens Mouth Neoplasms oral cancer cell lines and CAFs Interaction(miR-675-5p/PFKFB3 signaling pathway) Western Blot//Transfection//qRT-PCR//FISH//RNA-seq//Luciferase Report Assay//IHC//Bioinformatics Analysis//IF In the present study, by using RNA sequencing and bioinformatics analysis, we analyzed the lncRNA/mRNA profiles of normal fibroblasts (NFs) derived from normal tissues and CAFs derived from patients with oral squamous cell carcinoma (OSCC). LncRNA H19 was identified as a key lncRNA in oral CAFs and was synchronously upregulated in both oral cancer cell lines and CAFs . We found that knockdown of lncRNA H19 by siRNA suppressed the MAPK signaling pathway, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and miR-675-5p. Furthermore, the lncRNA H19/miR-675-5p/PFKFB3 axis was involved in promoting the glycolysis pathway in oral CAFs, as demonstrated by a luciferase reporter system assay and treatment with a miRNA-specific inhibitor. Yes Using small interfering RNA (siRNA) strategies, we determined that lncRNA H19 knockdown affected proliferation, migration, and glycolysis in oral CAFs. 33762576 H19 LncRNA Homo sapiens Mouth Neoplasms iCell-h120 cells Regulation(ZEB1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Colony Formation Assay Here, we identify an H19 transcript variant that lacks exon 4 in oral cancer specimens and carcinoma-derived cells. Through binding the ZEB1 mRNA, the variant H19 transcript without exon 4 promotes the expression of ZEB1 protein during epithelial-mesenchymal transition (EMT). Yes Depletion of H19 by short hairpin RNAs (shRNAs) targeting exon 1 but not exon 4 significantly inhibited oral cancer iCell-h120 cells growth and invasion in vitro and tumorigenesis of these cells in vivo. 33270342 H19 LncRNA Homo sapiens Wilms Tumor HFWT cells, nephroblastoma tissues Interaction(miR-675/TGFBI axis) CCK8//qRT-PCR//Tunel//Western Blot The gene expression levels of lncRNA H19 and miR-675 were markedly downregulated in nephroblastoma tissues (p<0.05), while that of TGFBI was notably upregulated (p<0.05). It upregulated the expressions of miR-675 and Caspase-8 (p<0.05), and downregulated TGFBI (p<0.05). Besides, miR-675 was able to upregulate Caspase-8 (p<0.05) and downregulate TGFBI (p<0.05). In addition, the protein expression of Caspase-8 was downregulated (p<0.05), while that of TGFBI was upregulated (p<0.05) after the knockdown of miR-675 in HFWT cells. Yes LncRNA H19 could reduce the proliferative ability of HFWT cells (p<0.05) and stimulates apoptosis rate (p<0.05). 35731049 H19 LncRNA Homo sapiens Thyroid Carcinoma, Anaplastic thyroid tissues Expression[highly expressed] CCK8//qRT-PCR//migration assay//cell invasion assay//Colony Formation Assay Expression of H19 was detected in 19 ATC and 19 normal thyroid tissues by real-time quantitative polymerase chain reaction. Yes H19 inhibited proliferation, migration, and invasion and induced apoptosis in 8505C cells in vitro and inhibited tumorigenesis and metastasis in vivo. 31299871 H19 LncRNA Homo sapiens Osteoporosis OP samples regulation[LncRNA H19/miR-29a-3p axis] CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay The expression of lncRNA H19 was significantly upregulated in OP samples compared with the health control. Thus, we concluded that lncRNA H19/miR-29a-3p axis was involved in the development of OP. Yes Furthermore, the knockdown of lncRNA H19 was validated to promote the expression of pro-inflammatory mediators, repress cell proliferation and inhibit cell apoptosis in vitro. 33207859 H19 LncRNA Homo sapiens Respiratory Distress Syndrome MH-S & MLE-12 Interaction(microRNA-423-5p/FOXA1 axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC The expression of H19 and FOXA1 was significantly up-regulated, while the expression of miR-423-5p was down-regulated in LPS-induced ARDS rats. Silencing of H19 decreased the mRNA expression of TNF-α, IL-1β, IL-6, MCP-1, and VEGF, the contents of TNF-α, IL-1β, IL-6, and VEGF in BALF, and histology score in LPS-induced ARDS rats. H19 knockdown also reduced the fibrosis scores and the protein expression of vimentin and α-SMA, and elevated the protein expression of E-cadherin in LPS-induced ARDS rats. Furthermore, silencing of miR-423-5p and overexpression of FOXA1 reversed the inhibitory effects of si-H19 on the inflammation and fibrosis of LPS-induced MH-S cells. Yes Silencing of H19 decreased the mRNA expression of TNF-α, IL-1β, IL-6, MCP-1, and VEGF, the contents of TNF-α, IL-1β, IL-6, and VEGF in BALF, and histology score in LPS-induced ARDS rats. H19 knockdown also reduced the fibrosis scores and the protein expression of vimentin and α-SMA, and elevated the protein expression of E-cadherin in LPS-induced ARDS rats. Furthermore, silencing of miR-423-5p and overexpression of FOXA1 reversed the inhibitory effects of si-H19 on the inflammation and fibrosis of LPS-induced MH-S cells. 33629893 H19 LncRNA Homo sapiens Keloid keloid tissues and fibroblasts Interaction(miR-769-5p/EIF3A pathway) Western Blot//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay Our study found that lncRNA H19 expression was increased in keloid tissues and fibroblasts. Further experiments showed that microRNA (miR)-769-5p could be sponged by H19, and its knockdown reversed the suppression effect of H19 knockdown on keloid formation. Eukaryotic initiation factor 3A (EIF3A) was found to be a target of miR-769-5p, and its overexpression inverted the inhibition effect of miR-769-5p overexpression on keloid formation. Yes Besides, H19 knockdown hindered the proliferation, migration, invasion, extracellular matrix (ECM) deposition, and enhanced the apoptosis of keloid fibroblasts. 33389493 H19 LncRNA Homo sapiens Keloid keloid tissue and fibroblasts Interaction(miR-196b-5p/SMAD5) qRT-PCR H19 and SMAD5 expression was upregulated in keloid tissue and fibroblasts, whereas miR-196b-5p expression was downregulated. miR-196b-5p was identified as a H19 sponge, and SMAD5 was identified as a miR-196b-5p target. Yes Knockdown of H19, overexpression of miR-196b-5p, or knockdown of SMAD5 inhibited the viability and proliferation of keloid fibroblasts and promoted apoptosis. Overexpression of H19 or SMAD5 and knockdown of miR-196b-5p promoted viability and proliferation and inhibited apoptosis. 34974806 H19 LncRNA Homo sapiens Pituitary Neoplasms ulcerative edge tissues of DFU interaction[binding to miR-29b] qRT-PCR In the ulcerative edge tissues of DFU, high expression of lncRNA H19 and FBN1 and low expression of miR-29b were observed. Altogether, upregulation of lncRNA H19 can elevate the expression of FBN1 through competitively binding to miR-29b, which enhances the proliferation, migration, and inhibits apoptosis of fibroblasts, thus facilitating the wound healing of DFU. Yes Silencing of lncRNA H19 led to inhibited proliferation, migration, and enhanced apoptosis of fibroblasts, accompanied by downregulated FBN1 but upregulated miR-29b, which diminished the expression of TGF-β1, Smad3, FN, and Col-1 and reduced extracellular matrix accumulation. 33174326 H19 LncRNA Homo sapiens Aortic Aneurysm, Thoracic TAA aorta tissues and serum and vascular smooth muscle cell (VSMC) Interaction(miR-1-3p/ADAM10 Axis ) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay H19 was increased in TAA aorta tissues and serum and vascular smooth muscle cell (VSMC), and hindered proliferation as well as promoted apoptosis and extracellular matrix (ECM) degradation of VSMC. Moreover, miR-1-3p was decreased, and ADAM10 was upregulated in TAA aorta tissues and VSMC. The mechanical analysis confirmed that H19 affected ADAM10 expression by targeting miR-1-3p. Yes H19 was increased in TAA aorta tissues and serum and vascular smooth muscle cell (VSMC), and hindered proliferation as well as promoted apoptosis and extracellular matrix (ECM) degradation of VSMC. 34478010 H19 LncRNA Homo sapiens Diffuse Intrinsic Pontine Glioma DIPG Tissue Interaction( let-7 microRNAs) Transfection//Wound Healing Assay//RNA-seq//Cell Proliferation Assay//Bioinformatics Analysis We found that H19 expression was higher in DIPG vs. normal brain tissue and other pedHGGs. Mechanistically, H19 buffers let-7 microRNAs, resulting in the up-regulation of oncogenic let-7 target (e.g., SULF2 and OSMR) Yes H19 knockdown resulted in decreased cell proliferation and survival in DIPG cells.  34502082 H19 LncRNA Homo sapiens Acute Lung Injury sepsis patient Expression(lower expressed) qRT-PCR//ELISA//Luciferase Report Assay//Western Blot lncRNA H19 was downregulated in sepsis. lncRNA H19 alleviated sepsis-induced ALI by inhibiting pulmonary apoptosis and inflammation, serving as a biochemical marker and therapeutic target for sepsis. The AUC of lncRNA H19 for early diagnosis of sepsis was 0.8197 (95% CI, 0.77 to 0.91). Yes Upregulation of lncRNA H19 inhibited TNF-α, IL-6, IL-17, caspase-3, caspase-9 and Bax and increased Bcl-2. 35317444 H19 LncRNA Homo sapiens neuroendocrine carcinoma pNEN tissues Regulation[PI3K/AKT/CREB signaling] RNA Pull-Down//qPCR//RNA-seq H19 was significantly upregulated in pNEN tissues with malignant behaviors, and the upregulation predicted poor prognosis in pNENs.Furthermore, VGF was downregulated when H19 was knocked down, and VGF promoted cell proliferation, migration and invasion. Mechanistic investigations revealed that H19 activated PI3K/AKT/CREB signaling and promoted pNEN progression by interacting with VGF. These findings indicate that H19 is a promising prognostic factor in pNENs with malignant behaviors and functions as an oncogene via the VGF-mediated PI3K/AKT/CREB pathway. Yes In vitro and in vivo data showed that H19 overexpression promoted tumor growth and metastasis, whereas H19 knockdown led to the opposite phenotypes.c 31117050 H19 LncRNA Homo sapiens Myocardial Infarction MI patients Interaction(PBX3/CYP1B1-dependent manner) Western Blot//Transfection//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//H&E Staining//ELISA Downregulated H19 and upregulated CYP1B1 were observed in MI patients. Overexpression of CYP1B1 could abrogate the suppressive effect of H19 on pyroptosis of cardiomyocytes. H19 could inhibit activity of CYP1B1 promoters by regulating PBX3. Yes Transfection of H19 overexpression or CYP1B1 knockdown could attenuate the MI progression in MI rats. In hypoxic cardiomyocytes, H19 overexpression or CYP1B1 knockdown could also inhibit NLRP3, ASC, caspase-1, IL-1β, and IL-18 in addition to suppressing cell apoptosis rate and promoting cell proliferation rate. 33389498 H19 LncRNA Homo sapiens Lung Injury CLP mice models and LPS-induced cell injury models Interaction(miR-301a-3p/Adcy1) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA//EdU Staining LncH19 was lowly expressed in CLP mice models and LPS-induced cell injury models. MiR-301a-3p could be sponged by lncH19, and its overexpression could reverse the inhibition of lncH19 on LPS-induced cell injury. Adcy1 was a target of miR-301a-3p, and its expression was upregulated by lncH19. Silencing of Adcy1 could abolish the suppressive effect of the miR-301a-3p inhibitor on LPS-induced cell injury. Yes Overexpressed lncH19 could alleviate CLP-induced lung injury in mice, as well as LPS-induced cell apoptosis, inflammation, and oxidative stress. 35438054 H19 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues regulation[miR-675-5p/GPR55] qRT-PCR//Luciferase Report Assay LncRNA H19 was expressed at lower levels in TSCC tissues than in normal tissues. The lncRNA H19/miR-675-5p/GPR55 axis might inhibit cell proliferation, invasion and migration in TSCC. Yes When lncRNA H19 was overexpressed, miR-675-5p expression levels were also upregulated, leading to reduced proliferation, invasion and migration of CAL27 and SCC9 cells. 35117434 H19 LncRNA Homo sapiens Glioma cell lines Regulation[miR-138/HIF-1α/VEGF axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Yes We investigated the regulatory roles and downstream molecular mechanisms of lncRNA H19 in glioma by knockdown H19, which inhibited the proliferation, migration and angiogenesis of glioma cells. Moreover, miR-138 acted as a target of H19 as detected by luciferase reporter assays. 31777264 H19 LncRNA Homo sapiens Glioma glioma tissues Regulation[Wnt/β-catenin signaling pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay H19 expression in glioma tissues was higher than that in para-carcinoma tissues and associated with poor prognosis in glioma patients. Downregulation of H19 decreased DVL2, cyclin D1, and β-catenin expression and increased GSK-3β expression. The inhibitory effects of downregulation of H19 on glioma cell proliferation, invasion, and migration were reversed by SKL2001 via the activation of the Wnt/β-catenin signal pathway, which was further enhanced by inhibition of the Wnt/β-catenin signal pathway by XAV939. Yes Cell proliferation, invasion, and migration significantly decreased, the percentage of glioma cells in G0/G1 significantly increased, the percentage of glioma cells in the S phase significantly decreased, and apoptosis significantly increased in U251 and U87MG cells transfected with siRNA-H19 compared to those in the siRNA-NC group. 31173296 H19 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[Wnt5a/β-Catenin Pathway ] Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay H19 and Wnt5a expression were remarkably upregulated in glioma tissues and cells, whereas miR-342 expression was downregulated. H19 regulates glioma cell growth and metastasis through miR-342 to mediate Wnt5a/β-catenin signaling pathway, which provides new therapeutic targets for glioma treatment. Yes Moreover, functional analysis confirmed that knockdown of H19 or overexpression of miR-342 suppressed glioma cell proliferation, migration, and angiogenesis in vitro. 33161527 H19 LncRNA Homo sapiens Glioma glioma cells Interaction(miR-200a/CDK6/ZEB1 axis) In Vivo Experiment//Western Blot//Transfection//qPCR//CCK8//Luciferase Report Assay//Microarray//Transwell Assay As a novel oncogenic factor, up-regulation of H19 was able to promote the proliferation of glioma cells by targeting miR-200a.In summary, our findings suggested that the expression of H19 was elevated in glioma, which could promote the growth, invasion and migration of tumor cells via H19/miR-200a/CDK6/ZEB1 axis. Yes As a novel oncogenic factor, up-regulation of H19 was able to promote the proliferation of glioma cells by targeting miR-200a.Furthermore, elevated miR-200a levels could reverse H19-induced cell growth and metastasis. 34796112 H19 LncRNA Homo sapiens Glioma glioma cells Regulation(mTOR/ULK1 pathway.) Western Blot//Transfection//CCK8//qRT-PCR//EdU Staining//Transwell Assay We observed that overexpressed H19 promoted the proliferation and migration in glioma cells. In conclusion, we validate that H19 contributes to the proliferation and autophagy of glioma cells through the mTOR/ULK1 pathway. Yes We observed that overexpressed H19 promoted the proliferation and migration in glioma cells. The autophagy of U87 cells was suppressed when H19 was overexpressed and enhanced when H19 was silenced. 33661803 H19 LncRNA Homo sapiens Glioma human glioma cell lines Interaction(miR-152 ) In Vivo Experiment//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay The results showed that H19 expression was upregulated and miR-152 expression was downregulated in human glioma cell lines. Taken together, H19 promoted glioma cell proliferation and invasion by negatively regulating miR-152 expression, providing evidence for the potential application of H19 as a biomarker and therapy target for glioma. Yes H19 downregulation or miR-152 upregulation suppressed glioma cell proliferation and invasion in vitro. 29422115 H19 LncRNA Homo sapiens Nasopharyngeal carcinoma nasopharyngeal tissues Interaction[ let-7] qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay H19 was aberrantly over-expression in nasopharyngeal carcinoma, which intimately associated with poorer prognosis.Mechanistically, H19 competitively sponged let-7 genes and therefore Expression[up-expression]-regulated HRAS, which consequently contributed to its oncogenic activity in nasopharyngeal carcinomas. Yes H19-deficency significantly inhibited cell viability and sExpression[up-expression]pressed cell proliferation. Furthermore, both migrative and invasive capacity were compromised by H19 knockdown. H19-silencing remarkably delayed xenograft tumour progression and lung metastasis. 31556327 H19 LncRNA Homo sapiens Nasopharyngeal carcinoma cell lines Expression[highly expressed] CCK8//qRT-PCR//Colony Formation Assay//Flow Cytometry In NPC cells, lncRNA H19 was up-regulated. Yes Silencing lncRNA H19 inhibited the proliferation of NPC C666-1 cells and promoted apoptosis, while overexpression of lncRNA H19 promoted the proliferation of NPC C666-1 cells and inhibited apoptosis. 32736275 H19 LncRNA Homo sapiens Glioblastoma GBM tissues and cells Interaction(miR-491-5p) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//CCK8//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay The expression H19 was increased in GBM and was positively correlated with LC3 or Beclin-1. H19 regulated the autophagy signaling pathway at least partly via miR-491-5p. Increased H19 expression in GBM exerts oncogenic effects by sponging miR-491-5p and enhancing autophagy. Therefore, H19 may be explored as a target for GBM therapy. Yes Silencing H19 inhibited growth and promoted apoptosis in GBM cells both in vitro and in vivo, and miR-491-5p was identified as one of the important mediators. 35506168 H19 LncRNA Homo sapiens Thyroid Neoplasms TC tissues Interaction[PI3K/AKT pathway] Flow Cytometry//qRT-PCR//MTT//Western Blot The results indicated that H19 was upregulated in TC tissues.Silencing of H19 inhibited the cell viability and promoted apoptosis of FTC-133 and TPC-1 TC cells, accompanied by an increased expression of B-cell lymphoma 2 (Bcl-2)-associated X protein and caspase 3, and repressed expression of Bcl-2. The results of western blot analysis suggested that the levels of phosphorylated phosphoinositide-3 kinase (PI3K) and phosphorylated AKT were attenuated by H19 silencing. These results suggest that lncRNA H19 exerts an oncogenic function in TC, in part through the PI3K/AKT pathway. Yes Silencing of H19 inhibited the cell viability and promoted apoptosis of FTC-133 and TPC-1 TC cells, accompanied by an increased expression of B-cell lymphoma 2 (Bcl-2)-associated X protein and caspase 3, and repressed expression of Bcl-2. 31410148 H19 LncRNA Homo sapiens Multiple Myeloma MM patients interaction[miR-152-3p] qRT-PCR//Luciferase Report Assay//IHC We found that levels of H19 and BRD4 were upregulated and the expression of miR-152-3p was downregulated in MM patients. Taking these results together, H19 knockdown suppresses MM tumorigenesis via inhibiting BRD4-mediated cell proliferation through targeting miR-152-3p, implying that H19 is a promising biomarker and drug target for MM. Yes Knockdown of H19 repressed proliferation and enhanced apoptosis and cell cycle G1 arrest by upregulating miR-152-3p in MM cells. Furthermore, H19 knockdown suppressed the growth of xenograft tumor, reduced Ki-67 and BRD4 levels, and increased cell apoptosis in xenograft tumor tissues. 31712391 H19 LncRNA Homo sapiens Pancreatic Neoplasms PDAC tissues Regulation[H19/miR-194/PFTK1 axis] qRT-PCR In PDAC tissues, the expression of H19 and PFTK1 were upregulated. As analyzed by TCGA and predicted by online tools, miR-194 was negatively correlated with PFTK1 and might bind to both H19 and PFTK1, which was further confirmed by luciferase reporter and RNA immunoprecipitation assays. Moreover, the effect of H19 knockdown on PFTK1 protein and the cell proliferation and migration could be partially reversed by miR-194 inhibition; H19/miR-194 axis modulated PDAC cell proliferation and migration through PFTK1 downstream Wnt signaling. Results suggested that rescuing miR-194 expression in PDAC can inhibit lncRNA H19 and PFTK1 expression, subsequently suppressing PDAC cell proliferation and migration. Due to the complexity of the lncRNA-miRNA-mRNA network, further in vivo experiments examining potential side effects are needed in future study to explore the clinical application of these findings. Yes H19 knockdown suppressed the cell proliferation and migration of PDAC, while PFTK1 overexpression partially attenuated the suppressive effect of H19 knockdown. 30474270 H19 LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues Interaction[ targeting miR-29b-3p and modifying STAT3] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Simultaneously, expression of epithelial‑mesenchymal transition (EMT)‑specific proteins was significantly altered, i.e. increased epithelial cadherin expression, as well as decreased vimentin, Snail and Slug expression. Furthermore, miR‑29b‑3p was verified to be targeted and regulated by H19, and STAT3 was targeted and modified by miR‑29b‑3p. Ultimately, STAT3 was identified to decrease lung adenocarcinoma cell viability, survival, apoptosis and EMT imposed by miR‑29b‑3p. In conclusion, the results of the present study indicated that lncRNA H19/miR‑29b‑3p/STAT3 signaling was involved in the development of lung adenocarcinoma, which may be critical for developing effective diagnostic and treatment strategies for lung adenocarcinoma. Yes The results indicated that highly expressed H19 and poorly expressed miR‑29b‑3p could serve as predictors for the poor prognosis of lung adenocarcinoma patients. Additionally, si‑H19 and miR‑29b‑3p mimic significantly increased the apoptosis of lung adenocarcinoma cells, and decreased the survival rate and viability of cells. 30747209 H19 LncRNA Homo sapiens Adenocarcinoma of Lung LAC tissues and cells Interaction(Mutant p53 R175H) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay Mtp53 R175H and H19 were over-expressed in LAC tissues and cells, while H19 over-expression extended the p53 half-life and enhanced transcriptional activity. Combined with anti-p53, ShH19 can significantly inhibit tumor growth in vivo. Yes Mtp53 R175H and H19 were over-expressed in LAC tissues and cells, while H19 over-expression extended the p53 half-life and enhanced transcriptional activity. Combined with anti-p53, ShH19 can significantly inhibit tumor growth in vivo. 36139647 H19 LncRNA Homo sapiens Alzheimer Disease Aβ25-35-treated PC12 cells as well as in brain tissues of AD mice Interaction(MiR-129/HMGB1 axis) RNA Pull-Down//Western Blot//Flow Cytometry//FISH//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay Elevated H19, HMGB1 and decreased miR-129 were found in Aβ25-35-treated PC12 cells as well as in brain tissues of AD mice. H19 could specifically bind to miR-129. MiR-129 specifically suppressed HMGB1 expression. Yes Silenced H19 or elevated miR-129 promoted viability, inhibited apoptosis, prevented mitochondrial membrane potential dysfunction and decreased oxidative stress in Aβ25-35-treated PC12 cells. 33410377 H19 LncRNA Homo sapiens Diabetes Mellitus, Type 2 tissues Regulation(p53 ) Wound Healing Assay Mechanistically, lncH19 relieves the cell cycle arrest of fibroblasts and increases macrophage infiltration in injured tissues via inhibiting p53 activity and GDF15 releasement. Furthermore, exosomes derived from adipocyte progenitor cells efficiently restore the impaired diabetic wound healing via delivering lncH19 to injured tissue. Yes Mechanistically, lncH19 relieves the cell cycle arrest of fibroblasts and increases macrophage infiltration in injured tissues via inhibiting p53 activity and GDF15 releasement. Furthermore, exosomes derived from adipocyte progenitor cells efficiently restore the impaired diabetic wound healing via delivering lncH19 to injured tissue. 35472819 H19 LncRNA Homo sapiens Melanoma melanoma tissues Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry H19 was highly expressed in melanoma tissues compared to normal adjacent skin tissues, and the tissue expression level of H19 from melanoma patients with metastasis was significantly higher than that from patients without distant metastasis. In addition, the high expression of H19 in melanoma tissues was associated with advanced tumor invasion and TNM stage, distal metastasis, lymph node metastasis and shorter overall survival in patients with melanoma. Yes The in vitro functional assays showed that knockdown of H19 inhibited cell growth, invasion and migration and also induced cell apoptosis as well as G0/G1 arrest in melanoma cells. 29950863 H19 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues ,cell lines Interaction[Sponging miR-let-7] Transwell Assay//qRT-PCR//Luciferase Report Assay//Western Blot Here we found that the expression of H19 was elevated in TSCC tissues compared with adjacent normal tissues. Moreover, we demonstrated that the expression of H19 was higher in metastasized tumors compared with unmetastasized tumors. Moreover, we demonstrated that the expression of H19 was higher in metastasized tumors compared with unmetastasized tumors. Yes Moreover, we demonstrated that the expression of H19 was higher in metastasized tumors compared with unmetastasized tumors. 29523225 H19 LncRNA Homo sapiens Skin Neoplasms cSCC tissues and cSCC cell lines Interaction(microRNA‑675/p53axis) Western Blot//Transfection//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay The results of the present study revealed that the expression levels of H19 and miR‑675 were upregulated in cSCC tissues and cSCC cell lines. The overexpression of H19 upregulated the expression levels of its predicted target, miR‑675, which subsequently promoted the EMT process and downregulated the expression levels of p53. Yes The knockdown of H19 or miR‑675 expression inhibited cell proliferation, migration and invasion, but induced cell apoptosis. In addition, the expression levels of EMT‑related markers were also downregulated. 33649811 H19 LncRNA Homo sapiens Heart Injuries H9C2 cells Interaction(miR-93-5p/SORBS2 Axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//ELISA H19 and SORBS2 were downregulated in H9C2 cells following LPS treatment, while miR-93-5p was upregulated. Moreover, H19 sponged miR-93-5p to promote SORBS2 expression. Overall, H19 suppressed sepsis-induced myocardial injury via regulation of the miR-93-5p/SORBS2 axis. Yes Moreover, LPS-induced cell growth inhibition and mitochondrial damage were significantly reversed by overexpression of H19. In addition, H19 upregulation notably suppressed LPS-induced inflammatory responses in H9C2 cells. 32996061 GACAT3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tissues and A549cell Interaction(TIMP2/MMP10) qRT-PCR//MTT//Luciferase Report Assay Using lncRNA array analysis, we found that GACAT3 expression increased significantly. TIMP2, confirmed a direct target of GACAT3 by bioinformatics analysis and our experiments, may be involved in the GACAT3-induced upregulation of MMP10. Yes Further studies showed that overexpression of ectopic GACAT3 in A549 cells promoted cell proliferation and migration, and enhanced the sensitivity of lung cancer cells to radiotherapy. 29565489 H1-10-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues regulation[H1FX-AS1/miR-324-3p/DACT1 axis ] qRT-PCR//RNA Pull-Down//Luciferase Report Assay Lower H1FX-AS1 expression in CC tissues was found to be associated with the poor prognosis of CC patients. Therefore, H1FX-AS1 is a new prognostic predictor and targeting the factors in the H1FX-AS1/miR-324-3p/DACT1 axis is the novel potential therapeutic strategy for CC. Lower H1FX-AS1 expression in CC tissues was found to be associated with the poor prognosis of CC patients. Yes Over-expression of H1FX-AS1 inhibited CC cell proliferation, migration and invasion, while induced apoptosis by sponging miR-324-3p to up-regulate the DACT1 expression level. 32760225 GSTP1P1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[ miR-142-3p/Bach-1 Axis] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The expression of Lnc712 was upregulated in HCC, and the upregulated Lnc712 expression was significantly related to poor overall survival in HCC patients.Lnc712 may promote the development of HCC by targeting the miR-142-3p/Bach-1 axis. The expression of Lnc712 was upregulated in HCC, and the upregulated Lnc712 expression was significantly related to poor overall survival in HCC patients. Yes In addition, Lnc712 promoted HCC cell proliferation, migration, invasion and cell cycle, while its effects were abolished by miR-142-3p mimic. Furthermore, Lnc712 knockdown remarkably inhibited HCC tumor growth in nude mice. 33177878 GSTP1P1 LncRNA Homo sapiens Osteosarcoma OS tissues Interaction(MiR-129-5p) Cell Proliferation Assay//qRT-PCR//Transfection Lnc712 was upregulated in OS and was inversely correlated with miR-129-5p. In OS cells, Lnc712 overexpression failed to significantly affect miR-129-5p, while miR-129-5p overexpression led to downregulated Lnc712. Cell proliferation showed that Lnc712 overexpression resulted in increased cell proliferation rate. MiR-129-5p overexpression played an opposite role and reversed the effect of Lnc712 overexpression. Yes In OS cells, Lnc712 overexpression failed to significantly affect miR-129-5p, while miR-129-5p overexpression led to downregulated Lnc712. Cell proliferation showed that Lnc712 overexpression resulted in increased cell proliferation rate. MiR-129-5p overexpression played an opposite role and reversed the effect of Lnc712 overexpression. 33732018 GSTM3TV2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-597/FOSL2 Axis) qRT-PCR We observed that the expression of lncRNA GSTM3TV2 and FOSL2 were upregulated in HCC. The luciferase reporter assays showed that lncRNA GSTM3TV2 could be directly bound to miR-597, and the level of miR-597 was also decreased in the tumor tissues. lncRNA GSTM3TV2 could stabilize FOSL2 expression, resulting in the oncogenic properties of lncRNA GSTM3TV2 in HCC. Yes Knockdown of lncRNA GSTM3TV2 significantly inhibited cell proliferation. Meanwhile, the migration and invasion of HCC cells were greatly decreased by the downregulated lncRNA GSTM3TV2. 34458365 GSEC LncRNA Homo sapiens Osteosarcoma osteosarcoma cell lines regulation[miR-588/ EIF5A2 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that the expression of LncRNA GSEC was up-regulated in osteosarcoma cell lines.In summary, this study shows that LncRNA GSEC promotes the proliferation and invasion of OS through the regulation of miR-588/EIF5A2 pathway, which might provide a new strategy for the treatment of osteosarcoma in the future. Yes Overexpression of LncRNA GSEC promoted the proliferating and migratory capacity, and inhibited the apoptosis of osteosarcoma cells. Conversely, knockdown of LncRNA GSEC resulted in the opposite effect. 32868080 GSEC LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cancer cell line Interaction(miR-202-5p/AXL Axis.) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay GSEC was significantly upregulated in TNBC tissues and cancer cell lines, and high level of GSEC was associated with advanced tumor stage, positive lymph-node metastasis and the poor prognosis of TNBC patients. GSEC regulated the expression of AXL by directly sponging miR-202-5p. Downregulation of miR-202-5p attenuated GSEC knockdown-induced inhibition on TNBC cell proliferation, invasion and migration in vitro. Meanwhile, overexpression of AXL obviously reversed the inhibitory effects of miR-202-5p mimics in TNBC progression in vitro. GSEC was significantly upregulated in TNBC tissues and cancer cell lines, and high level of GSEC was associated with advanced tumor stage, positive lymph-node metastasis and the poor prognosis of TNBC patients. Yes Knockdown of GSEC effectively inhibited TNBC cell proliferation, invasion and migration in vitro. 33907418 GSEC LncRNA Homo sapiens Sepsis cell line Expression(highly expressed) qRT-PCR//Luciferase Report Assay//Western Blot Performing in vitro experiments, we found that the expression of GSEC lncRNA and PFKFB3 was increased when neutrophils were treated with inflammatory stimuli. In addition, we found that GSEC lncRNA-induced PFKFB3 expression was essential for mediating dHL-60 cell inflammatory cytokine expression. Performing mechanistic experiments, we found that glycolytic metabolism with PFKFB3 involvement supported inflammatory cytokine expression. Yes Knockdown and overexpression experiments showed that GSEC lncRNA was essential for mediating PFKFB3 mRNA expression and stability in neutrophil-like dHL-60 cells. 34907156 GRIK1-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cell line(GES-1) Interaction(miR-375/IFIT2 Axis) RNA Pull-Down//Western Blot//ISH//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Our results show a decreased expression of GRIK1-AS1 in gastric cancer tissues compared to adjacent normal gastric tissues. Gastric cell lines also have reduced levels of GRIK1-AS1 compared to gastric epithelial cell line GES-1. Our results revealed a novel mechanism of GRIK1-AS1 as a sponge to miR-375 that impacts gastric cancer progression via modulating target mRNA IFIT2 translation Yes Ectopic expression of GRIK1-AS1 in gastric cancer cell lines significantly inhibits cellular viability, migration, and invasion. 34660323 GREP1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells and clinical samples Regulation( Wnt/β-catenin pathway) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay We found that LINC00514 expression was elevated in NSCLC cells and clinical samples and that increased LINC00514 expression predicted poorer patient prognosis. Altogether, this study provides the latest convincing evidence that LINC00514 facilitates the malignant biological behavior of NSCLC cells through activation of the Wnt/β-catenin pathway, which might offer a beneficial approach for the treatment of NSCLC. We found that LINC00514 expression was elevated in NSCLC cells and clinical samples and that increased LINC00514 expression predicted poorer patient prognosis. Yes Silencing LINC00514 suppresses proliferation, migration, and invasion of NSCLC cells. Downregulation of LINC00514 inhibited Wnt/β-catenin signaling and epithelial-mesenchymal transition (EMT).Moreover, suppression of the biological phenotypes of NSCLC cells induced by LINC00514 gene silencing was restored after LiCl treatment. Finally, we found that silencing LINC00514 attenuated the growth of xenograft tumors in vivo. 35653786 GREP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR‑378a‑5p/SPHK1 signaling axis) CCK8//qRT-PCR//Western Blot The present study found that LINC00514 and sphingosine kinase 1 (SPHK1) were both upregulated in ESCC tissues and cells, and their high expression levels were closely associated with Tumor?Node?Metastasis stage, lymph node metastasis and poor prognosis of patients with ESCC.Mechanistically, LINC00514 functioned as a competing endogenous RNA by sponging microRNA (miR)‑378a‑5p, resulting in the upregulation of SPHK1, which was accompanied by the activation of lipogenesis‑related pathways, to promote ESCC cell proliferation and invasion. The present study found that LINC00514 and sphingosine kinase 1 (SPHK1) were both upregulated in ESCC tissues and cells, and their high expression levels were closely associated with Tumor-Node-Metastasis stage, lymph node metastasis and poor prognosis of patients with ESCC. Yes Functionally, knockdown of LINC00514 inhibited cell proliferation and invasion, and led to the downregulation of lipogenesis?related proteins, including SPHK1, fatty acid synthase, acetyl?coenzyme (Co)A carboxylase α and stearoyl?CoA desaturase 1, whereas LINC00514 overexpression promoted cell proliferation and invasion in ESCC KYSE150 and KYSE30 cells, and upregulated expression of lipogenesis?related proteins. 34533201 GREP1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines regulation[Regulating miR-708] qRT-PCR//ChIP We showed that LINC00514 expressions were distinctly upregulated in both OS tissues and cell lines, especially in advanced cases.Our findings revealed SP1-induced upregulation of LINC00514 as an oncogene in OS through competitively binding to miR-708, suggesting that there are potential diagnostic and treatment values of LINC00514 in OS. High levels of LINC0051 were positively correlated with advanced tumor stages, distant metastasis, and reduced survival of patients with OS. Yes Functional experiments indicated that silencing of LINC00514 suppressed the ability of cell growth, colony formation and metastasis, whereas promoted cell apoptosis in vitro. 32523373 GREP1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Regulation[miR-204-3p/CDC23 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay LINC00514 expression was significantly upregulated in papillary thyroid cancer (PTC) tissues by bioinformatics analysis. RNA-FISH showed that LINC00514 mainly locates in the nucleus of PTC cells. Through bioinformatics prediction, we identified that LINC00514 served as the sponge for miR-204-3p, and miR-204-3p directly targeted CDC23. Thus, LINC00514 promoted CDC23 expression via restraining miR-204-3p activity, leading to PTC progression. In sum, our findings demonstrated that LINC00514 contributes to PTC progression and might be a potential target for PTC therapy. Yes Loss-of-function studies revealed that LINC00514 silencing inhibited the proliferation, migration and invasion of PTC cells while promoting apoptosis in vitro. Moreover, LINC00514 knockdown suppressed PTC growth in vivo. 30553447 GREP1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines regulation[miR-28-5p] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay In this study, LINC00514 was shown to be upregulated in PC tissues and cell lines.his study is the first to characterize the oncogenic function of the long noncoding RNA LINC00514 in pancreatic cancer progression by acting as a competing endogenous RNA (ceRNA) of miR-28-5p to upregulate Rap1b expression. Increased LINC00514 expression was significantly associated with the clinical progression and prognosis of PC patients. Yes In addition, silencing LINC00514 inhibited PC cell proliferation, migration and invasion, while LINC00514 overexpression promoted these processes. 32771045 GREP1 LncRNA Homo sapiens cervical squamous cell carcinoma  Interaction(miR-708-5p/HOXB3 axis) Invasion assay//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Our results showed that the expression of LINC00514 was up-regulated in human CSCC tissues and cell lines. Yes Knockdown of LINC00514 significantly inhibited the proliferation and invasion of CSCC cells, as well as suppressed tumorigenesis of CSCC in vivo. In addition, LINC00514 was found to work as a miRNA sponge for miR-708-5p and suppressed the expression of miR-708-5p in CSCC cells. 34652879 GRASLND LncRNA Homo sapiens Glioma gliomas Interaction(miR-665/HMGA1 axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay RNF144A-AS1 and HMGA1 were high-expressed in gliomas, and miR-665 was low-expressed in gliomas, which led to the increase of glioma cell viability, proliferation, migration and invasion ability and insufficient apoptosis ability. Overexpression of RNF144A-AS1 suppressed the expressions of Bax and cleaved caspase-3, and promoted Bcl-2 expression. RNF144A-AS1 up-regulated the expression of HMGA1 by targeting miR-665, thereby promoting the development of glioma cells. Yes RNF144A-AS1 and HMGA1 were high-expressed in gliomas, and miR-665 was low-expressed in gliomas, which led to the increase of glioma cell viability, proliferation, migration and invasion ability and insufficient apoptosis ability. 34560189 GPC5-AS1 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues Interaction(miR-93/106a ) Western Blot//qRT-PCR//Cell Viability Assay//Cell Apoptosis Assay//Cell Cycle Assay//IHC//ChIP In the present study, we demonstrate that GPC5-AS1 is downregulated in GC cells and tissues, and this aberrant expression is regulated by MeCP2 through CpG site binding in the promoter region.Mechanistically, we demonstrated that GPC5-AS1 stabilizes GPC5 mRNA by acting as a molecular sponge for miR-93 and miR-106a, thereby reducing GC tumor progression. Yes Importantly, we also demonstrate that GPC5-AS1 overexpression suppresses cell proliferation, colony formation, and cell cycle transition; induces apoptosis in vitro; and inhibits tumorigenicity in vivo. 35183057 GPC3-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Regulation[GPC3-AS1/GPC3 axis] qRT-PCR A quantitative reverse transcriptase-polymerase chain reaction confirmed that GPC3-AS1 was up-regulated in CC cells compared to normal CRL-2614 cells. GPC3-AS1 positively regulated its nearby gene glypican 3 (GPC3). Significant up-regulation of GPC3 was also observed in CC cells, consistently with GPC3-AS1. In addition, GPC3-AS1 and GPC3 synergistically promoted the proliferative and migratory abilities of CC cells. Mechanistic investigation showed that ELK1 acted as the transcription activator of GPC3-AS1 and GPC3, thus contributing to their up-regulation in CC cells. Rescue assays indicated that the ELK1-induced GPC3-AS1/GPC3 axis promoted cell proliferation and migration in CC. Yes Loss-of-function assays demonstrated the negative effect of GPC3-AS1 depletion on CC cell proliferation and migration. 31168873 GOLPH3 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells Interaction(miRNA-1299/LIF axis) RNA Pull-Down//Western Blot//Transfection//Proliferation Assay//qRT-PCR//PCR//Invasion Assay//IF The expression of circGOLPH3 was upregulated in OSCC cells. Mechanistically, circGOLPH3 functioned as a microRNA sponge and downregulated miR-1299 expression. miR-1299 downregulated the expression of LIF by targeting its 3'-untranslated region. Inhibition of the circGOLPH3/miR-1299/LIF axis suppressed the growth, migration, and invasion of OSCC cells. These findings indicate that the circGOLPH3/miR-1299/LIF axis promotes OSCC cell growth, migration, and invasion and that this axis is a potential therapeutic target for OSCC. Yes circGOLPH3 promoted the growth of OSCC in vitro and in vivo. Additionally, circGOLPH3 upregulated OSCC cell migration and invasion. 35481460 GNAS-AS1 LncRNA Homo sapiens Osteoarthritis cartilage tissues Interaction[ACSL6 ] qRT-PCR//Western Blot Highly elevated levels of Nespas and Acyl-CoA synthetase 6 (ACSL6) were observed in OA patients.Overall, we suggest that elevated Nespas level in OA are associated with OA pathogenesis by suppressing miRs targeting ACSL6 and subsequent ACSL6 upregulation. Yes Both Nespas overexpression and ACSL6 upregulation into human chondrocytes induced typical OA characteristics, such as downregulation of type II collagen; upregulation of type I collagen, metalloproteinase 13, and caspase-1 and -3; and dysfunction of mitochondria and peroxisome. 28805067 GNAS-AS1 LncRNA Homo sapiens Osteosarcoma OS cells and tissues Expression(highly expressed) CCK8//qRT-PCR The expression of lncRNA GNAS-AS1 was significantly increased in OS cells and tissues, and related to Enneking staging and distant metastasis. The expression of lncRNA GNAS-AS1 was significantly increased in OS cells and tissues, and related to Enneking staging and distant metastasis. Patients with high lncRNA GNAS-AS1 expression represented shorter overall survival and was an independent prognostic predictor of OS. Yes LncRNA GNAS-AS1 knockdown inhibited cell proliferation, migration, and invasion by regulated miR-490-3p partly at least. 34321018 GTF2IRD2P1 LncRNA Homo sapiens Urinary Bladder Neoplasms human bladder cancer tissues and cell lines Regulation(Wnt/β‑catenin signaling pathway) qRT-PCR//Western Blot GTF2IRD2P1 expression was found to be lower in both human bladder cancer tissues and cell lines (UM-UC-3, RT4, and 5637), and elevated in T24 compared to the corresponding normal controls. Meanwhile, overexpression of GTF2IRD2P1 inhibited the proliferation of UM-UC-3 and prolonged the cell cycle. The silencing of GTF2IRD2P1 significantly increased the proliferation and shortened the cell cycle of T24 cells and induced Wnt signaling activity to promote the progression of bladder cancer. Yes Meanwhile, overexpression of GTF2IRD2P1 inhibited the proliferation of UM-UC-3 and prolonged the cell cycle. The silencing of GTF2IRD2P1 significantly increased the proliferation and shortened the cell cycle of T24 cells and induced Wnt signaling activity to promote the progression of bladder cancer. 35433119 H19 LncRNA Rattus norvegicus Renal Insufficiency, Chronic model rats and VSMCs Interaction(microRNA-138/TLR3) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Microarray//IF Long non-coding RNA (lncRNA) H19 was upregulated in the aortic tissues after HPD treatment. H19 bound to microRNA (miR)-138 to block its inhibitory effect on TLR3 mRNA and activated the NF-κB signaling pathway. Downregulation of H19 or TLR3 alleviated, whereas downregulation of miR-138 aggravated the calcification and vascular damage in model rats and VSMCs. Yes Downregulation of H19 or TLR3 alleviated, whereas downregulation of miR-138 aggravated the calcification and vascular damage in model rats and VSMCs. 35435133 H19 LncRNA Homo sapiens Prostatic Neoplasms Extensive computational analysis has identified a high degree of association between the long noncoding RNA (lncRNA) H19 and NEPC, with the longest isoform highly expressed in NEPC. H19 facilitates the PRC2 complex in regulating methylation changes at H3K27me3/H3K4me3 histone sites of AR-driven and NEPC-related genes. Regulation Western Blot//Transwell Assay//qRT-PCR//RIP//Luciferase Report Assay//RNA-seq//IHC//Invasion Assay//ChIP Extensive computational analysis has identified a high degree of association between the long noncoding RNA (lncRNA) H19 and NEPC, with the longest isoform highly expressed in NEPC. H19 facilitates the PRC2 complex in regulating methylation changes at H3K27me3/H3K4me3 histone sites of AR-driven and NEPC-related genes. Yes . H19 regulates PCa lineage plasticity by driving a bidirectional cell identity of NE phenotype (H19 overexpression) or luminal phenotype (H19 knockdown). It contributes to treatment resistance, with the knockdown of H19 re-sensitizing PCa to ADT. It is also essential for the proliferation and invasion of NEPC. 34934057 H19 LncRNA Rattus norvegicus Chronic Constriction Injury rats Interaction(miR-141/GLI2 axis) In Vivo Experiment//RNA Pull-Down//qRT-PCR//Luciferase Report Assay//ELISA//Bioinformatics Analysis LncRNA H19 was upregulated in the tissues of rats. Furthermore, miR-141 was reduced in CCI rats and restored by the lncRNA H19 knockdown, suggesting the potential negative associations of miR-141 with lncRNA H19. GLI2 targeted miR-141 and GLI2 was increased in CCI rats. Additionally, the neuropathic pain was inhibited by the inhibition of GLI2 in rats, which was reversed by the miR-141 inhibitors. Yes Also, thermal hyperalgesia and mechanical allodynia were inhibited by lncRNA H19 suppression in rats.Moreover, IL-1β, IL-6 and TNF-α protein concentrations were suppressed by the downregulation of lncRNA H19 in rats. 34999183 H19 LncRNA Homo sapiens Aortic Dissection thoracic aorta tissues of AD patients Interaction(miR-193b-3p) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis LncRNA H19 was abnormally high-expressed in thoracic aorta tissues of AD patients, and it could competitively bind to and inhibit miR-193b-3p. Yes In the PDGF-BB group, the expressions of H19, matrix metallopeptidase (MMP) 2 (MMP-2) and MMP-9 were up-regulated and the expressions of miR-193b-3p, α-SMA, and SM22α were down-regulated; moreover, the proliferation and migration rate of HASMCs were increased. However, H19 silencing reversed the regulation of PDGF-BB on HASMCs. More interestingly, miR-193b-3p inhibitor could partially reverse the effect of H19 silencing. In addition, the above results were verified by animal experiments, showing that shH19 and up-regulated miR-193b-3p could significantly reduce the thoracic aorta pathological damage in AD mice. 33403385 H19 LncRNA Homo sapiens Acute Kidney Injury murine ischemic kidney tissue, Ecs, TECs Interaction(miR-30a-5p) In Vivo Experiment//Western Blot//Transfection//qPCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//IHC//EdU Staining//ChIP H19 is upregulated in kidney biopsies of patients with AKI, in murine ischemic kidney tissue, and in cultured and ex vivo sorted hypoxic endothelial cells (ECs) and tubular epithelial cells (TECs). Sponging of miR-30a-5p mediated the effects, which, in turn, led to target regulation of Dll4, ATG5, and Snai1. Yes H19 overexpression promotes angiogenesis in vitro and in vivo. In vivo, transient AAV2-mediated H19 overexpression significantly improved kidney function, reduced apoptosis, and reduced inflammation, as well as preserving capillary density and tubular epithelial integrity. 33478972 H19 LncRNA Homo sapiens Pneumonia WL-38 cell Interaction(miR-22-3p/NLRP3 axis) Western Blot//Transfection//Tunel//qRT-PCR//MTT//Luciferase Report Assay//ELISA//Bioinformatics Analysis//IF In the LPS induced pneumonia model, LncRNA H19 silences inhibited LPS-induced WL-38 cell pyroptosis, and LncRNA H19 overexpression promotes LPS-induced WL-38 cell pyroptosis. Also, LncRNA H19 acts as a sponge of miR-22-3p, which targets NLRP3, and NLRP3 attenuates the effect of LncRNA H19 silencing on LPS-induced WL-38 cell pyroptosis. Yes In the LPS induced pneumonia model, LncRNA H19 silences inhibited LPS-induced WL-38 cell pyroptosis, and LncRNA H19 overexpression promotes LPS-induced WL-38 cell pyroptosis. Also, LncRNA H19 acts as a sponge of miR-22-3p, which targets NLRP3, and NLRP3 attenuates the effect of LncRNA H19 silencing on LPS-induced WL-38 cell pyroptosis. 34786066 H19 LncRNA Homo sapiens Pneumonia peripheral blood of patients with pneumonia, WI-38 cells Interaction(miR-140-5p/TLR4 Axis) qRT-PCR//ELISA//MTT LncRNA H19 and TLR4 were up-regulated, while miR-140-5p was downregulated in peripheral blood of patients with pneumonia and LPS-treated WI-38 cells compared with their controls. H19 targeted miR-140-5p and it inversely regulated miR-140- 5p expression. MiR-140-5p targeted TLR4 and it inversely regulated TLR4 expression. H19 positively regulated TLR4 expression. Moreover, inhibition of miR-140-5p or overexpression of TLR4 reversed the effects of H19 silencing on cell viability, inflammation, and apoptosis in LPS-induced WI-38 cells. Yes Silencing of H19 or miR-140-5p mimics facilitated cell viability, whereas repressed apoptosis and reduced content of TNF-α, IL-6, and IL-1β in LPS-induced WI-38 cells. 35392782 H19 LncRNA Homo sapiens Liver Cancer Bone Metastasis cells with distinct bone metastasis ability Regulation(PPP1CA-induced inactivation of the p38MAPK pathway) In Vivo Experiment H19 was highly expressed in these cells and in clinical HCC bone metastasis specimens. Both osteoclastogenesis in vitro and HCC bone metastasis in vivo were promoted by H19 overexpression, whereas these processes were suppressed by H19 knockdown. H19 overexpression attenuated p38 phosphorylation and further down-regulated the expression of osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor. However, up-regulated OPG expression as well as suppressed osteoclastogenesis caused by H19 knockdown were recovered by p38 interference, indicating that p38 mitogen-activated protein kinase (MAPK)-OPG contributed to H19-promoted HCC bone metastasis. Furthermore, we demonstrated that H19 inhibited the expression of OPG by binding with protein phosphatase 1 catalytic subunit alpha (PPP1CA), which dephosphorylates p38. SB-203580-mediated inactivation of p38MAPK reversed the down-regulation of HCC bone metastasis caused by H19 knockdown in vivo. Additionally, H19 enhanced cell migration and invasion by up-regulating zinc finger E-box binding homeobox 1 through the sequestration of microRNA (miR) 200b-3p. Yes Both osteoclastogenesis in vitro and HCC bone metastasis in vivo were promoted by H19 overexpression, whereas these processes were suppressed by H19 knockdown. H19 overexpression attenuated p38 phosphorylation and further down-regulated the expression of osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor. However, up-regulated OPG expression as well as suppressed osteoclastogenesis caused by H19 knockdown were recovered by p38 interference, indicating that p38 mitogen-activated protein kinase (MAPK)-OPG contributed to H19-promoted HCC bone metastasis. Furthermore, we demonstrated that H19 inhibited the expression of OPG by binding with protein phosphatase 1 catalytic subunit alpha (PPP1CA), which dephosphorylates p38. SB-203580-mediated inactivation of p38MAPK reversed the down-regulation of HCC bone metastasis caused by H19 knockdown in vivo. 33615520 H19 LncRNA Homo sapiens Lung Neoplasms lung bronchial epithelial cell (16HBE) and COE induced malignant transformed cell Interaction(H19/miR-29a-3p/COL1A1 axis) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq H19 and COL1A1 were significantly higher in Rf than in 16HBE and miR-29a-3p was reverse. Regulatory investigation revealed H19 increased COL1A1 expression by sponging miR-29a-3p. In conclusion, all these indicated H19 functioned as a ceRNA to increase COL1A1 by sponging miR-29a-3p and promoted COE-induced cell malignant transformation. Yes Knockdown of H19, COL1A1 or overexpression of miR-29a-3p in Rf cells could inhibit cell proliferation, increased cell adhesion and p53 level. However, knockdown of H19 while suppressing the miR-29a-3p partially rescue the malignant phenotype of Rf caused by H19. 36150622 H19 LncRNA Mus musculus Osteoarthritis OA mice Interaction(TP53, IL-38, IL-36R) IF//Luciferase Report Assay//ChIP//Western Blot TP53 was responsible for lncRNA H19-mediated upregulation of IL-38. Furthermore, it was found that the anti-inflammatory effects of IL-38 were achieved by its binding with the IL-36 receptor (IL-36R). Overexpression of H19 reduced the expression of inflammatory factors and chondrocyte apoptosis, which was abrogated by knockdown of IL-38 or TP53. Yes TP53 was responsible for lncRNA H19-mediated upregulation of IL-38. Furthermore, it was found that the anti-inflammatory effects of IL-38 were achieved by its binding with the IL-36 receptor (IL-36R). Overexpression of H19 reduced the expression of inflammatory factors and chondrocyte apoptosis, which was abrogated by knockdown of IL-38 or TP53. 35942891 H19 LncRNA Mus musculus Atherosclerosis aortic tissues Interaction[upregulating PKD1 ] Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//H&E Staining//ChIP H19 was upregulated in aortic tissues of atherosclerosis mice, but silencing of H19 significantly inhibited atherosclerotic vulnerable plaque formation and intraplaque angiogenesis, accompanied by a downregulated expression of MMP-2, VEGF, and p53 and an upregulated expression of TIMP-1. The present study provides evidence that H19 recruits CTCF to downregulate the expression of PKD1, thereby promoting vulnerable plaque formation and intraplaque angiogenesis in mice with atherosclerosis. Yes Moreover, opposite results were found in the aortic tissues of atherosclerosis mice treated with H19 or CTCF overexpression. 31757932 H19 LncRNA Mus musculus Atherosclerosis thoracic aortas regulation[p53] CCK8//qRT-PCR//Western Blot Compared with the control group, mouse weight and plaque area were all increased in the AS model group, as was the expression of H19.Results from the present study indicated that knockdown of H19 may prevent AS deterioration through increased p53‑mediated VSMC apoptosis. Yes Knockdown of H19 reduced the proliferation and induced apoptosis of VSMCs, and increased the expression of p53, cleaved caspase3 (c?caspase3) and p53 upregulated modulator of apoptosis, as well as enhancing the interaction between Bax and p53 proteins. 32945413 H19 LncRNA Mus musculus Atherosclerosis mouse blood and aorta Interaction(miR-146a-5p/ANGPTL4 Pathway) Western Blot//Transfection//FISH//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis The outcomes from this research illustrated that the expression of lncRNA H19 was elevated in mouse blood and aorta with lipid-loaded macrophages and atherosclerosis. The upregulation of lncRNA H19 decreased the miR-146a-5p expression but increased the levels of ANGPTL4 in mouse blood and aorta and THP-1 cells. Yes Adeno-associated virus (AAV)-mediated lncRNA H19 overexpression significantly increased the atherosclerotic plaque area in apoE-/- mice supplied with a Western diet. 34820432 H19 LncRNA Mus musculus Myocardial Infarction myocardial tissue Interaction[ regulating KDM3A] RNA Pull-Down//Western Blot//RIP//qRT-PCR//Luciferase Report Assay We found that H19 was significantly down-regulated after MI. Bioinformatics analysis and dual-luciferase assays revealed that, mechanistically, miR-22-3p was a direct target of H19, which was also confirmed by RIP and RNA pull-down assays in primary cardiomyocytes. In addition, bioinformatics analysis and dual-luciferase reporter assays also demonstrated that miRNA-22-3p directly targeted the KDM3A gene. Moreover, subsequent rescue experiments further verified that H19 regulated the expression of KDM3A to ameliorate MI-induced myocardial injury in a miR-22-3p-dependent manner. The present study revealed the critical role of the lncRNAH19/miR-22-3p/KDM3A pathway in MI. These findings suggest that H19 may act as a potential biomarker and therapeutic target for MI. Yes Functionally, enforced H19 expression dramatically reduced infarct size, improved cardiac performance and alleviated cardiac fibrosis by mitigating myocardial apoptosis and decreasing inflammation. However, H19 knockdown resulted in the opposite effects. 31755219 H19 LncRNA Mus musculus Colitis, Ulcerative colon tissues Interaction(miR-331-3p/TRAF4 ) RNA Pull-Down//qPCR//Luciferase Report Assay//ELISA//Bioinformatics Analysis H19 was highly expressed in colon tissues.Mechanically, lncRNA-H19 is bound to miR-331-3p to inhibit its expression. TRAF4 is a target of miR-331-3p. Inhibition of miR-331-3p or overexpression of TRAF4 could reverse the alleviating role of lncRNA-H19 in intestinal injury of UC mice. Yes Silencing H19 attenuated intestinal injury of UC mice, manifested by reductions in weight loss, DAI, histopathological scores, IL-1β and TNF-α, and increases in colon length and IL-10. 35483327 H19 LncRNA Mus musculus Diabetic Cardiomyopathies C57/BL-6j mice Regulation(PI3K/AKT/mTOR axis) In Vivo Experiment//qPCR//Bioinformatics Analysis//Western Blot H19 could reduce the expression of p-PERK, p-IRE1α, ATF6, CHOP, cleaved caspase-3, cleaved caspase-9, cleaved caspase-12, and BAX proteins in cardiac tissues. Furthermore, H19 repressed oxidative stress, ERS and apoptosis in vitro. Moreover, the effect of H19 on ERS-associated apoptosis might be rescued by LY294002 (the specific inhibitor for PI3K and AKT). Yes H19 improved left ventricular dysfunction in DM. H19 could reduce cardiomyocytes apoptosis and improve fibrosis in vivo. 36044268 H19 LncRNA Mus musculus Brain Injuries HIBD cell model Interaction(miR-107 and Up-Regulating Vascular Endothelial Growth Factor) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//RIP//Luciferase Report Assay//IF Yes H19 overexpression reduced neuronal apoptosis and alleviated cognitive dysfunction in HIBD rats. 33608066 H19 LncRNA Mus musculus Pulmonary Fibrosis pulmonary fibrotic tissues Regulation[H19-miR-140-TGF-β/Smad3 signaling] qRT-PCR//ELISA//Luciferase Report Assay//Western Blot Here, our observations showed that H19 expression was significantly upregulated and that of microRNA 140 (miR-140) was markedly reduced in pulmonary fibrotic tissues from idiopathic pulmonary fibrosis (IPF) patients and transforming growth factor β1 (TGF-β1)-induced HBE and A549 cells. The study of molecular mechanisms showed that H19 functioned via reduction of miR-140 expression by binding to miR-140. The increase of miR-140 inhibited TGF-β1-induced pulmonary fibrosis, and H19 upregulation diminished the inhibitory effects of miR-140 on TGF-β1-induced pulmonary fibrosis, which was involved in the TGF-β/Smad3 pathway. Taken together, our findings showed that H19 knockdown attenuated pulmonary fibrosis via the regulatory network of lncRNA H19-miR-140-TGF-β/Smad3 signaling, and H19 and miR-140 might represent therapeutic targets and early diagnostic and prognostic biomarkers for patients with pulmonary fibrosis. Yes Furthermore, animal experiments showed that H19 knockdown attenuated BLM-induced pulmonary fibrosis in mice. 30988156 H19 LncRNA Mus musculus Sepsis kidney tissues of IRI mice Interaction(miR-196a/Wnt/β-Catenin Signaling) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//IHC//IF lncRNA-H19 is upregulated, and miR-196a-5p is downregulated in kidney tissues of IRI mice.Moreover, miR-196a-5p is a direct target of lncRNA-H19. lncRNA-H19 overexpression promotes kidney fibrosis and activates fibroblasts during AKI-CKD development, while miR-196a-5p overexpression reversed these effects in vitro. Furthermore, lncRNA-H19 overexpression significantly upregulates Wnt1 and β-catenin expression in kidney tissues and fibroblasts of IRI mice, while miR-196a-5p overexpression downregulates Wnt1 and β-catenin expression in kidney tissues and fibroblasts of IRI mice. Yes Moreover, miR-196a-5p is a direct target of lncRNA-H19. lncRNA-H19 overexpression promotes kidney fibrosis and activates fibroblasts during AKI-CKD development, while miR-196a-5p overexpression reversed these effects in vitro. 34818249 H19 LncRNA Mus musculus Bronchopulmonary Dysplasia Hyp-induced mice Interaction(miR-17/STAT3) Other Hyp-induced mice showed increased alveolar diameter, septum, and hyperemia and inflammatory cell infiltration, upregulated H19, decreased overall number and significantly reduced RAC on the 7th and 14th days after birth, which were reversed in the si-H19-treated mice. Moreover, H19 competitively bound to miR-17 to upregulate STAT3. IL-6 and IL-1β expressions and p-STAT3 and STAT3 levels were downregulated after inhibition of H19. Yes VEGF was upregulated and TGF-β1 and SPC was decreased in si-H19-treated mice. 33285606 H19 LncRNA Rattus norvegicus Polycystic Ovary Syndrome ovarian tissues & serum samples and cumulus cells Regulation(Cyp17) In Vivo Experiment//qRT-PCR//Western Blot tudies have suggested that the increased testosterone synthesis seen in PCOS is driven in part by increased activity of CYP17A1, the rate-limiting enzyme for the formation of androgens in the gonads and adrenal cortex, which represents a critical factor driving enhanced testosterone secretion in PCOS. In this work, we evaluated the hypothesis that dysregulation of the noncoding RNA H19 results in aberrant CYP17 and testosterone production. To achieve this, we measured Cyp17 in ovarian tissues of H19 knockout mice, and quantified serum testosterone levels, in comparison with wild-type controls. We also evaluated circulating and ovarian H19 expression and correlated results with the presence or absence of PCOS in a group of women undergoing evaluation and treatment for infertility. We found that the loss of H19 in a mouse model results in decreased ovarian Cyp17, along with decreased serum testosterone in female mice. Moreover, utilizing serum samples and cumulus cells from women with PCOS, we showed that circulating and ovarian levels of H19 are increased in women with PCOS compared to controls. Findings from our multimodal experimental strategy, involving both a mouse model of dysregulated H19 expression and clinical serum and ovarian cellular samples from women with PCOS, suggest that the loss of H19 may disrupt androgen production via a Cyp17-mediated mechanism. Conversely, excess H19 may play a role in the pathogenesis of PCOS-associated hyperandrogenemia. Yes We found that the loss of H19 in a mouse model results in decreased ovarian Cyp17, along with decreased serum testosterone in female mice. 34655046 H19 LncRNA Rattus norvegicus Cerebral Hemorrhage rats with ICH Regulation( NF-κBp65 and IKKβ expression) qRT-PCR//ELISA//Western Blot In addition, the expression of lncRNA H19 in the brain tissue in the ICH group was significantly higher than that in the sham group. Western blot results showed that the expression of NF-κBp65 and IKKβ was significantly higher, and IκBα expression was lower in the perivascular hematoma tissue in the ICH group compared with the sham group. Compared with the sh-NC group, NF-κBp65 and IKKβ expression were significantly lower and IκBα was significantly higher in the sh-H19 group. Yes After further interference with lncRNA H19 expression (sh-H19 group), the levels of all the above indicators were reversed and the neurological damage was improved. 35075368 H19 LncRNA Homo sapiens Glioma glioma tissues interaction[miR-130a-3p ] qRT-PCR//Luciferase Report Assay//RIP H19 was overexpressed in glioma tissues.H19 and SOX4 are both direct target of miR-130a-3p. H19 could compete with SOX4 via sponging miR-130a-3p. Yes Down-regulation of H19 led to the inhibition of migration, invasion and EMT process with a reduction in N-cadherin and Vimentin. 30282068 H19 LncRNA Homo sapiens Triple Negative Breast Neoplasms breast cancer tissues and cell lines regulation[p53/TNFAIP8 pathway] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of lncRNA H19 and TNFAIP8 was up-regulated in breast cancer tissues and cell lines, especially in triple-negative breast cancer (TNBC). Our findings provide insight into a novel mechanism of lncRNA H19 in tumorigenesis and metastases of breast cancer and demonstrate H19/p53/TNFAIP8 axis as a promising therapeutic target for breast cancer, especially for TNBC. Yes Functionally, knockdown of lncRNA H19 or TNFAIP8 coused the capacities of cell proliferation, migration, and invasion were suppressed, and cell cycle arrest was induced, as well as that the EMT markers were expressed abnormal. 32514245 H19 LncRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues,cell lines (Eca109, kyse410, kyse510, TE-1, TE-5) Regulation[STAT3/EZH2 axis] Western Blot//qRT-PCR//RIP//MTT//Transwell Assay Our results showed that the mRNA level of H19 was significantly increased in EC versus normal tissue(P < 0.01, Fig.1A). This result was validated in five EC cell lines (Eca109, kyse410, kyse510, TE-1, TE-5) and HEEC. Compared to HEEC, the level of H19 was elevated in all five PC cell lines, of which Eca109 and TE-5 had exhibited the most significant increase in H19 expression (Fig. 1B).Our results showed that the mRNA level of H19 was significantly increased in EC versus normal tissue(P < 0.01, Fig.1A). Yes KnockExpression[down-expression] of lncRNA H19 repressed cell proliferation, migration and invasion as well as EMT and metastasis via STAT3-EZH2-β-catenin pathway, while lncRNA H19 regulated STAT3 negatively regulated let-7c in EC cell lines. 31102664 HAND2-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction(microRNA-21-5p/TIMP3/VEGFA axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//Flow Cytometry//RIP//FISH//Luciferase Report Assay//Transwell Assay HAND2-AS1 and TIMP3 were downregulated in cervical cancer, which were identified to be associated with a poor prognosis of patients with cervical cancer. Moreover, HAND2-AS1 was upregulated the expression of TIMP3 through competitively binding to miR-21-5p. In summary, HAND2-AS1 may exert inhibitory effects on cervical cancer cell growth and cervical cancer development through its regulation on the miR-21-5p/TIMP3/VEGFA axis. HAND2-AS1 and TIMP3 were downregulated in cervical cancer, which were identified to be associated with a poor prognosis of patients with cervical cancer. Yes Overexpressed HAND2-AS1 or downregulated miR-21-5p inhibited cell proliferation, migration, and invasion while promoting cell apoptosis, in association with increased expression of proteins in VEGFA signaling pathway. These changes were reversed by silencing of TIMP3.Overexpressed HAND2-AS1 reduced the tumor formation ability in nude mice. 33139818 HAND2-AS1 LncRNA Homo sapiens Glioma glioma tissues and cell lines. Interaction(CDK6 ) Western Blot//Transfection//CCK8//qRT-PCR//Transwell Assay Our results revealed that HAND2-AS1 expression was significantly downregulated in the glioma tissues and cell lines.However, overexpression of CDK6 could partially block the inhibitory role of HAND2-AS1 on cell proliferation as well as cell invasion and migration in glioma cell lines. Yes Moreover, overexpression of HAND2-AS1 attenuated the proliferation, invasion, and migration in glioma cell lines. 35548927 HAND2-AS1 LncRNA Homo sapiens Atherosclerosis plasma from patients with atherosclerotic plaques and macrophages Interaction(miR-1208/SIRT1 axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis As a result, SIRT1 and HAND2-AS1 expression significantly decreased in plasma from patients with atherosclerotic plaques and macrophages originating from THP-1 induced by ox-LDL. Altogether, HAND2-AS1 targeting miR-1208/SIRT1 axis alleviates the formation of foam cells within AS. Yes Lentivirus mediated HAND2-AS1 overexpression markedly inhibited lipid absorption and deposition within foam cells originating from THP-1 macrophages. 34780888 HAND2-AS1 LncRNA Homo sapiens Melanoma melanoma tumor tissues Interaction[ROCK1 ] CCK8//qRT-PCR//Western Blot In the present study, it was revealed that lncRNA HAND2-AS1 was Expression[down-expression]regulated, whereas Rho-associated protein kinase 1 (ROCK1) mRNA was Expression[Expression[up-expression]-expression]regulated in tumor tissues when compared with the healthy tissues of patients with melanoma. Expression levels of lncRNA HAND2-AS1 and ROCK1 were inversely correlated in tumor tissues, but not in healthy tissues. Yes LncRNA HAND2-AS1 overexpression led to inhibited melanoma cancer cell proliferation and an increased expression level of ROCK1. 31423160 HAND2-AS1 LncRNA Homo sapiens Liver Neoplasms liver cancer cells regulation[SOCS5,JAK-STAT Pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The authors discovered the downregulated HAND2-AS1 in liver cancer cells. HAND2-AS1 enhanced inactivation of the JAK-STAT pathway through sponging miR-3118 and facilitating SOCS5 to retard cell proliferation and migration in liver cancer. Yes HAND2-AS1 augmentation apparently impaired the capacity of liver cancer viability, proliferation, and migration. 32155348 HAND2-AS1 LncRNA Homo sapiens gastric adenocarcinoma GA tissues and cells regulation[miR-184/HIF3A signaling] qRT-PCR//Luciferase Report Assay//Transwell Assay//Western Blot The HAND2-AS1 and HIF3A expressions were down-regulated and miR-184 expression was up-regulated in GA tissues and cells. LncRNA HAND2-AS1 could inhibit GA cell proliferation, migration and invasion abilities and glycolytic process induced by hypoxia through miR-184/HIF3A signaling. Yes In addition, HAND2-AS1 rescued enhanced AGS cell proliferation, cell migration, cell invasion abilities and glycolytic process caused by hypoxia via miR-184/HIF3A. 32431548 HAND2-AS1 LncRNA Homo sapiens esophagus squamous cell carcinoma ESCC tissue Interaction[regulating microRNA-21] CCK8//qRT-PCR//Transwell Assay In this study, we found that lncRNA HAND2-AS1 was Expression[down-expression]regulated, while microRNA-21 ( miRNA-21) was Expression[Expression[up-expression]-expression]regulated in tumor tissues than in adjacent healthy tissues of ESCC patients.Expression levels of lncRNA HAND2-AS1 and miRNA-21 were significantly and inversely correlated in tumor tissues but not in healthy tissues.miRNA-21 overexpression failed to affect lncRNA HAND2-AS1 expression but significantly attenuated the inhibitory effect of lncRNA HAND2-AS1 overexpression on cancer cell proliferation, migration, and invasion. Yes lncRNA HAND2-AS1 overexpression resulted in Expression[down-expression]regulation of miRNA-21 in cells of ESCC cell lines and inhibited cell proliferation, migration, and invasion. 30520131 HAND2-AS1 LncRNA Homo sapiens cervical squamous cell carcinoma blood Interaction[downregulating ROCK1] Western Blot//qPCR//CCK8//ELISA//Transwell Assay The current study revealed that lncRNA HAND2-AS1 was downregulated, while Rho-associated protein kinase 1 (ROCK1) was upregulated in serum of human papillomavirus (HPV)-positive and -negative patients with CSCC compared with healthy controls.Additionally, lncRNA HAND2-AS1 overexpression led to reduced expression levels of ROCK1 in HPV-positive and -negative human CSCC cell lines but not in normal cervical cell lines. ROCK1 overexpression did not significantly affect the expression of lncRNA HAND2-AS1 in all the cell lines investigated. lncRNA HAND2-AS1 overexpression inhibited, while ROCK1 overexpression promoted the proliferation, migration and invasion of HPV-positive and -negative human CSCC cell lines but not normal cervical cell lines. ROCK1 overexpression attenuated the effects of lncRNA HAND2-AS1 overexpression on cancer cell proliferation, migration and invasion. lncRNA HAND2-AS1 may inhibit cancer cell proliferation, migration and invasion by downregulating ROCK1 in HPV-positive and -negative CSCC. Yes lncRNA HAND2-AS1 overexpression inhibited, while ROCK1 overexpression promoted the proliferation, migration and invasion of HPV-positive and -negative human CSCC cell lines but not normal cervical cell lines. 31555362 HAND2-AS1 LncRNA Homo sapiens Arthritis, Rheumatoid RA synovial tissues Interaction(miR-143-3p/TNFAIP3/NF-κB pathway) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA//Transwell Assay HAND2-AS1 was lowly expressed in RA synovial tissues, and HAND2-AS1 re-expression suppressed the proliferation, motility, and inflammation and triggered the apoptosis in RA-FLSs via the inactivation of NF-κB pathway. Mechanistically, HAND2-AS1 directly sponged miR-143-3p and positively regulated TNFAIP3 expression, the target of miR-143-3p. Yes HAND2-AS1 was lowly expressed in RA synovial tissues, and HAND2-AS1 re-expression suppressed the proliferation, motility, and inflammation and triggered the apoptosis in RA-FLSs via the inactivation of NF-κB pathway. 33549125 HAND2-AS1 LncRNA Homo sapiens Diabetes Mellitus plasma Expression[lower expressed] qRT-PCR//Cell Apoptosis Assay LncRNA HAND2-AS1 was downregulated in diabetic patients with chronic renal failure but not in diabetic patients without obvious complications. Yes Overexpression of lncRNA HAND2-AS1 inhibited the apoptosis of mouse podocyte cells under high glucose treatment. 32411303 HAGLROS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[repressing miR-100 and up-regulating SMARCA5] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Up-regulated HAGLROS expression was observed in NSCLC tissues and cell lines.These results conclude that HAGLROS is a tumor promoter in NSCLC, and it regulates the malignant phenotypes of NSCLC cells via miR-100/SMARCA5 axis. Yes Over-expressed HAGLROS promoted the malignant phenotypes of NSCLC cells; conversely, HAGLROS knockdown repressed the malignant phenotypes of NSCLC cells. 35307327 HAGLROS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung non-small cell lung cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Transwell Assay We identified HAGLROS was significantly overexpressed in non-small cell lung cancer samples compared to normal tissues. Higher expression of HAGLROS was significantly associated with shorter overall survival time in patients with non-small cell lung cancer. Yes Moreover, we found knockdown of HAGLROS in non-small cell lung cancer cells remarkably suppressed tumour proliferation, migration and invasion. 32484214 HAGLROS LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[miR-5095/ATG12 axis] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay The level of HAGLROS was higher in HCC tissues and correlated with clinical performances including tumor stages or tumor differentiation.Our results revealed that HAGLROS is highly expressed in HCC, and its high level may correlate with the progression and development of HCC involving the processes of cell viability, apoptosis, and autophagy through the miR-5095/ATG12 axis and PI3K/AKT/mTOR signals. The level of HAGLROS was higher in HCC tissues and correlated with clinical performances including tumor stages or tumor differentiation. In contrast to the lower level, a higher level of HAGLROS correlated with a shorter survival time of patients with HCC. Yes The suppression of HAGLROS decreased cell viability, promoted apoptosis, and inhibited autophagy. 31082725 HAGLROS LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-26b-5p/KPNA2) CCK8//qRT-PCR In the current study, HAGLROS exhibited a higher level in HCC tissues and cells.vMechanistically, HAGLROS could competitively bind to miR-26b-5p to prevent the suppression of miR-26b-5p on its downstream target gene Karyopherin α2 (KPNA2). Moreover, the inhibitory effects of HAGLROS knockdown on cell malignant behaviors were reversed due to the miR-26b-5p down-regulation or KPNA2 overexpression. It was interesting to note that HAGLROS inactivated p53 signaling through targeting miR-26b-5p/KPNA2. HAGLROS expression was positively correlated with tumor size, TNM stage and poor clinical prognosis. Yes Loss-of-function experiments showed that knockdown of HAGLROS significantly lowered cell proliferation, cell cycle progression, migration, invasion and epithelial to mesenchymal transition (EMT) but induced apoptosis in vitro. Consistently, tumor growth in the nude mice was effectively slowed by the depletion of HAGLROS. 35291921 HAGLROS LncRNA Homo sapiens Ovarian Neoplasms OV cells Interaction(miR-26b-5p) qRT-PCR//Tunel//Western Blot The results indicated that HAGLROS was highly expressed in OV cells. Further study revealed that HAGLROS acted as a sponge for miR-26b-5p and positively regulated its expression. Yes Interference of HAGLROS led to a decrease in the proliferation, but an increase in the apoptosis of OV cells, accompanied by downregulated expression levels of Ki67 and Bcl-2, and upregulated expression levels of Bax and cleaved caspase-3. 34194557 HAGLROS LncRNA Homo sapiens Osteosarcoma osteosarcoma samples and cell lines regulation[HAGLROS/miR-152/ROCK1 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In our study, we found that the expression of HAGLROS increased osteosarcoma samples and cell lines compared with normal tissues and cells. The results showed HAGLROS/miR-152/ROCK1 axis might act as a novel therapeutic strategy for osteosarcoma. Yes HAGLROS knockdown inhibited certain functions of U2OS and SW1353 cells in vitro. Moreover, HAGLROS depletion inhibited tumor growth and metastasis in vivo. 32963586 HAGLROS LncRNA Homo sapiens Esophageal Neoplasms EC cell lines and tissues Interaction(miR-206- NOTCH3 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay HAGLROS is upregulated in esophageal squamous cell carcinoma (ESCC) tissues and predicts poor prognosis. HAGLROS promotes EC cell tumorigenesis in vivo. HAGLROS participates in the HAGLROS/miR-206/NOTCH3 regulatory axis in EC cells. Yes Silent HAGLROS is negatively associated with malignant behavior in EC cells. Low expression of HAGLROS can induce decreased invasive and migratory abilities in EC cells. Downregulated HAGLROS significantly inhibits the proliferation of EC cells and accelerates apoptosis. 34790377 HAGLROS LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues and cells Interaction(miR-100) In Vivo Experiment//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay HAGLROS was upregulated in DLBCL tissues and cells, and closely associated with advanced clinicopathological features. Further experiments revealed that HAGLROS negatively regulated the expression of miR-100 in DLBCL, and the expression of miR-100 and HAGLROS showed an inverse correlation in DLBCL tissues. HAGLROS was upregulated in DLBCL tissues and cells, and closely associated with advanced clinicopathological features. Upregulation of HAGLROS resulted in poor survival outcomes in DLBCL patients. Yes . In addition, HAGLROS knockdown inhibited the proliferation, migration, and invasion of DLBCL cells in vitro. 34888946 HAGLROS LncRNA Homo sapiens lung carcinoma LCa tissues Interaction[sponging microRNA-152] qRT-PCR HAGLROS was highly expressed in LCa tissues compared with adjacent normal tissues. MicroRNA-152 was negatively correlated with HAGLROS in LCa. Rescue experiments showed that the knockdown of microRNA-152 reversed the regulatory effects of HAGLROS on proliferative and migratory abilities of LCa cells. LCa patients with a higher expression of HAGLROS presented significantly worse tumor stage, a higher rate of lymphatic metastasis, and a lower survival. Yes The knockdown of HAGLROS significantly attenuated the proliferative and migratory abilities of LCa cells.Meanwhile, HAGLROS over-expression obtained the opposite results. 31378893 HAGLROS LncRNA Homo sapiens Wilms Tumor nephroblastoma cell lines Expression(highly expressed) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//IF//Cell Apoptosis Assay//Cell Proliferation Assay//Transwell Assay Experiment results showed that HAGLROS expressed highly in nephroblastoma cell lines. Yes HAGLROS knockdown prevented cells from proliferating, and also showed suppressive impact on migration and invasion in HFWT cells. In addition, knockdown of HAGLROS showed a facilitative effect on apoptosis and an inhibitory effect on autophagy. Stimulation of autophagy alleviated HAGLROS silencing-induced apoptosis, while inhibition of autophagy reversed the effect in nephroblastoma cells. 35358010 HAND2-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms tumor tissues and adjacent healthy tissues, Interaction[KLHDC7B] CCK8//qRT-PCR//Western Blot In patients with early-stage TNBC, the expression level of lncRNA HAND2-AS1 was Expression[down-expression]regulated, whilst runt-related transcription factor 2 (RUNX2) mRNA was Expression[Expression[up-expression]-expression]regulated in tumor tissues, compared with paired healthy tissues. Expression levels of lncRNA HAND2-AS1 and RUNX2 mRNA were inversely correlated in tumor tissues, but not in paired healthy tissues. Decreased plasma expression levels of lncRNA HAND2-AS1 were observed in TNBC patients compared with those in healthy controls, and the Expression[down-expression]regulation of lncRNA HAND2-AS1 distinguished patients with TNBC from healthy controls. Yes lncRNA HAND2-AS1 overexpression inhibited RUNX2 expression, whilst RUNX2 overexpression did not significantly affect lncRNA HAND2-AS1 expression in the MDA-MB-231 and BT-20 cell lines. lncRNA HAND2-AS1 overexpression resulted in the inhibition of cell proliferation, while RUNX2 overexpression promoted the proliferation of TNBC cells. RUNX2 overexpression partially reversed the effects of lncRNA HAND2-AS1 overexpression on cancer cells. 31788122 HAND2-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cells regulation[C16orf74,E2F4] Western Blot//Transwell Assay//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Colony Formation Assay//ChIP HAND2-AS1 exhibited poor expression in cervical cancer, and HAND2-AS1 overexpression suppressed the proliferation, colony formation, migration and invasion of cervical cancer cells.In conclusion, this study provided evidence on the inhibitory effect of HAND2-AS1 on the development of cervical cancer through the suppression of C16orf74 expression by recruiting transcription factor E2F4. Yes HAND2-AS1 exhibited poor expression in cervical cancer, and HAND2-AS1 overexpression suppressed the proliferation, colony formation, migration and invasion of cervical cancer cells. 32314545 H19 LncRNA Homo sapiens Leukemia, Myeloid, Acute blood Interaction[targeting miR-29a-3p] CCK8//Luciferase Report Assay//Flow Cytometry//Western Blot The expression of lncRNA-H19 in AML patients was markedly higher than that in normal controls and compared with human embryonic kidney (HEK)-293T cells, AML cell Kasumi-1 exhibited an increased lncRNA-H19 expression. It is bound to micro RNA (miR)-29a-3p in a targeted manner. and the expression level of miR-29a-3p in AML patients was prominently lower than that in normal controls. After miR-29a-3p was inhibited, the expression of intranuclear β-catenin was significantly increased and the Wnt/β-catenin pathway critical molecules T-cell factor (TCF) and lymphoid enhancer factor 1 (LEF1) were evidently up-regulated after the down-regulation of miR-29a-3p. Yes LncRNA-H19 could promote cell proliferation, but suppress cell apoptosis. 31389605 HAS2-AS1 LncRNA Homo sapiens Breast Neoplasms cell lines Regulation(HAS2 ) qRT-PCR//Wound Healing Assay//Cell Viability Assay Moreover, the survival of patients with ER-negative tumors was higher when the expression of HAS2-AS1 was elevated.Unexpectedly, in these ER-negative cell lines, HAS2-AS1 is involved neither in the regulation of HAS2 nor in HA deposition. Moreover, the survival of patients with ER-negative tumors was higher when the expression of HAS2-AS1 was elevated. Yes Experiments with ER-negative cell lines as MDA-MB-231 and Hs 578T revealed that the overexpression of either the full-length HAS2-AS1 or its exon 2 long or short isoforms alone, strongly reduced cell viability, migration, and invasion, whereas HAS2-AS1 silencing increased cell aggressiveness. 35395387 HAS2-AS1 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissue,cell lines Regulation[ miR-466/RUNX2 axis] ChIP//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In the cells and tissue of EOC, HAS2-AS1 expression was markedly up-regulated.Mechanical investigation found that HAS2-AS1 could relive the RUNX2 protein expression via sponging the miR-466, acting as miRNA sponge. In conclusion, this finding suggests the CREB1/HAS2-AS1/miR-466/RUNX2 axis in the in the EOC tumorigenesis, providing the novel insight for the molecular mechanism of EOC. Besides, the overexpression of HAS2-AS1 indicated the poor clinical outcome of EOC patients. Yes Functionally, HAS2-AS1 knockdown suppressed the proliferation, invasion and tumor growth of EOC cells in vitro and in vivo. 31082772 HAS2-AS1 LncRNA Homo sapiens Glioma glioma tissues Regulation[PI3K/AKT signaling pathway ] qRT-PCR In our research, HAS2-AS1 expression was elevated in glioma tissues compared with normal brain tissues. In vitro studies suggested that knocking down HAS2-AS1 expression inhibited glioma cell viability, migration, and invasion through phosphoinositide 3-kinase/protein kinase B signaling pathway. . Moreover, high levels of HAS2-AS1 expression was observed in patients with glioma with high WHO grade (III-IV) or large tumor size ( > 4 cm). The survival analysis from The Cancer Genome Atlas showed glioma cases with high HAS2-AS1 expression that had shorter disease-free survival time and overall survival time than those with low HAS2-AS1 expression. Yes In vitro studies suggested that knocking down HAS2-AS1 expression inhibited glioma cell viability, migration, and invasion through phosphoinositide 3-kinase/protein kinase B signaling pathway. 30790335 HAS2-AS1 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[USF1 ] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay//ChIP HAS2-AS1 was highly expressed in glioma tissues and cells, and was significantly associated with poor prognosis.These results suggested that the transcription factor USF1 induced up-regulation of lncRNA HAS2-AS1 and promoted glioma cell invasion and migration. HAS2-AS1 was highly expressed in glioma tissues and cells, and was significantly associated with poor prognosis. Yes Silencing HAS2-AS1 expression inhibited glioma cell migration, invasion and EMT. 32776110 HAS2-AS1 LncRNA Homo sapiens Glioblastoma GBM cell lines Interaction(miR-137/LSD1) In Vivo Experiment//IHC//Western Blot//Transfection//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay HAS2-AS1 expression was upregulated in GBM cell lines, and HAS2-AS1 was localized mainly in the cytoplasm. Furthermore, HAS2-AS1 functioned as a ceRNA (competing endogenous RNA) of miR-137, leading to the disinhibition of its downstream target LSD1. The miR-137 level was downregulated by HAS2-AS1 overexpression and upregulated by HAS2-AS1 knockdown. In a subsequent study, LSD1 expression was negatively regulated by miR-137, while miR-137 reversed the LSD1 expression levels caused by HAS2-AS1. Yes In vitro, high HAS2-AS1 expression promoted proliferation, and knockdown of HAS2-AS1 significantly inhibited proliferation. Furthermore, HAS2-AS1 functioned as a ceRNA (competing endogenous RNA) of miR-137, leading to the disinhibition of its downstream target LSD1. 34094916 HAR1A LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung adenocarcinoma tissues Regulation(STAT3) qRT-PCR//Western Blot We found that lncRNA Highly Accelerated Region 1A (HAR1A) is significantly downregulated in lung adenocarcinoma (LUAD) and negatively associated with prognosis. Additionally, the knockdown of HAR1A accelerated NSCLC cell proliferation but inhibited apoptosis and vice versa. HAR1A regulated cellular activities through the STAT3 signaling pathway. The tumor-suppressing role of HAR1A was verified in the mouse model. We found that lncRNA Highly Accelerated Region 1A (HAR1A) is significantly downregulated in lung adenocarcinoma (LUAD) and negatively associated with prognosis. Yes Additionally, the knockdown of HAR1A accelerated NSCLC cell proliferation but inhibited apoptosis and vice versa. HAR1A regulated cellular activities through the STAT3 signaling pathway. The tumor-suppressing role of HAR1A was verified in the mouse model. 35740511 HAND2-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-769-5p/TCEAL7] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay Downregulation of HAND2-AS1 was found in GC tissues and cell lines.Taken together, our study showed that HAND2-AS1 exerts its tumor suppressive role in GC via regulating miR-769-5p/TCEAL7. Yes HAND2-AS1 overexpression inhibited GC cell proliferation, invasion, and arrested cell cycle at G0/G1 phase, whereas HADN2-AS1 knockdown significantly promoted cell proliferation and invasion. 32952069 HAND2-AS1 LncRNA Homo sapiens Breast Neoplasms cell lines regulation[miR-3118/PHLPP2 axis] RNA Pull-Down//IHC//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the current study, HAND2-AS1 was discovered to be low expressed in BC cell lines, and overexpression of HAND2-AS1 could repress proliferation, migration, and invasion but facilitate apoptosis in BC cells.In summary, our study testified that HAND2-AS1 suppressed BC growth by targeting the miR-3118/PHLPP2 axis, indicating that HAND2-AS1 could be regarded as a potential target for BC treatment. Yes In the current study, HAND2-AS1 was discovered to be low expressed in BC cell lines, and overexpression of HAND2-AS1 could repress proliferation, migration, and invasion but facilitate apoptosis in BC cells. 33015182 HAND2-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues interaction[miR-1275,SOX7] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Downregulation of HAND2-AS1 was detected in breast cancer and was associated with adverse clinical features and prognosis. LncRNA HAND2-AS1 sponging miR-1275 restrains proliferation and metastasis of breast cancer cells by regulating SOX7 expression. Downregulation of HAND2-AS1 was detected in breast cancer and was associated with adverse clinical features and prognosis. Yes Furthermore, overexpression of HAND2-AS1 restrained cell viability, migration and invasion in breast cancer. 31683462 HAND2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,blood Interaction[TGF-β1] Flow Cytometry//qRT-PCR//Western Blot//Transwell Assay In our study, we observed that levels of HAND2-AS1 were lower in tumor tissues than that in adjacent healthy tissues. Compared with healthy controls, plasma levels of HAND2-AS1 were lower, while levels of transforming growth factor β (TGF-β) were higher in NSCLC patients. Cancer cells with lncRNA HAND2-AS1 overexpression showed down-regulated TGF-β1, while TGF-β1 treatment showed no significant effects on lncRNA HAND2-AS1 expression. TGF-β1 attenuated the inhibitory effects of lncRNA HAND2-AS1 overexpression on cell migration, invasion and stemness. We concluded that lncRNA HAND2-AS1 may regulate the migration, invasion and stemness of NSCLC cells through interactions with TGF-β1. Yes LncRNA HAND2-AS1 overexpression inhibits, while exogenous TGF-β1 treatment promotes cell migration and invasion ability and cancer cell stemness. 30509963 HAND2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung tissues and serum regulation[ PI3K/Akt pathway] CCK8//qRT-PCR//Cell Apoptosis Assay//Western Blot HAND2-AS1 expression was significantly down-regulated in NSCLC. We conclude that HAND2-AS1 may suppress the proliferation of NSCLC cells by targeting PI3K/Akt pathway. HAND2-AS1 and tumor size of NSCLC patients were closely associated. Serum HAND2-AS1 can be used to effectively distinguish osteosarcoma patients from healthy controls, and it can also be used to predict prognosis of osteosarcoma patients. Yes HAND2-AS1 overexpression inhibited osteosarcoma cell proliferation, promoted cell apoptosis, and down-regulated phosphorylation of PI3K/Akt pathway-related proteins. 32975291 HAND2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues interaction[ miR-1275,KLF14 ] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In our study, we found that lncRNA HAND2-AS1 was markedly downregulated in CRC tissues. In conclusion, our study demonstrated that HAND2-AS1 exerts a suppressive role in CRC by sponging miR-1275 and modulating KLF14 expression. And its expression level was negatively correlated with metastasis and advanced stage in CRC patients. Furthermore, we showed that HAND2-AS1 low expression predicted poor prognosis. Yes Functionally, we found that overexpression of HAND2-AS1 obviously attenuated the proliferation and invasion of CRC cells. Ectopic expression of HAND2-AS1 also inhibited tumor propagation in vivo. 30078677 HAND2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[microRNA-300/SOCS5 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay HAND2-AS1 was down-regulated in HCC tissues and cell lines, and the expression level of HAND2-AS1 was positively correlated to patient survival. lncRNA HAND2-AS1 inhibits proliferation in HCC through regulating miR-300/SOCS5 axis. HAND2-AS1 was down-regulated in HCC tissues and cell lines, and the expression level of HAND2-AS1 was positively correlated to patient survival. Yes HAND2-AS1 over-expression reduced viability and proliferation in HCC cells. 32224127 HAND2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular serum regulation[ROCK2 ] qRT-PCR It was found that levels of HAND2?AS1 in serum were significantly lower, while serum levels of Rho?associated protein kinase 2 (ROCK2) in HCC patients were significantly increased compared with hepatitis B (HB) patients and healthy controls.It was therefore concluded that HAND2‑AS1 might mediate the downregulation of ROCK2 in HCC to inhibit cancer cell migration, proliferation and invasion. Yes HAND2?AS1 overexpression inhibited, while ROCK2 overexpression promoted HCC cell migration, proliferation and invasion. 31922232 HAND2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular plasma of patients with early-stage HCC Expression [lower expressed] qRT-PCR//Western Blot The plasma level of HAND2-AS1 was downregulated and that of RUNX2 was upregulated in patients with early-stage HCC compared with those in healthy controls. Yes HAND2-AS1 overexpression led to the downregulation of RUNX2 expression in human HCC cells, whereas RUNX2 failed to significantly affect HAND2-AS1 expression. HAND2-AS1 overexpression inhibited and RUNX2 overexpression promoted the proliferation of HCC cells. RUNX2 overexpression attenuated the inhibitory effects of HAND2-AS1 overexpression on cancer cell proliferation. 33566427 HAND2-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction(miR-146/RARB) qRT-PCR//Luciferase Report Assay Based on the RT2 lncRNA PCR Arrays analysis, we validated HAND2-AS1 declined in bladder cancer and negatively correlated with the depth of invasion and grades. Besides, one of the HAND2-AS1 sponges, miR-146, elevated in bladder cancer and targeted the tumor suppressor, retinoic acid receptor beta (RARB). We further demonstrated that the HAND2-AS1: miR-146: RARB complex promoted Caspase 3-mediated apoptosis by suppressing COX-2 expression. Based on the RT2 lncRNA PCR Arrays analysis, we validated HAND2-AS1 declined in bladder cancer and negatively correlated with the depth of invasion and grades. Yes The overexpression of HAND2-AS1 in human bladder cancer cells 5637 and RT4 hampered cell proliferation by provoking Caspase 3-triggered cell apoptosis. 34238300 HAND2-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cells Interaction(miR-17-5p/ KLF9 Axis) qRT-PCR//Wound Healing Assay//Luciferase Report Assay Results showed that HAND2-AS1 was downregulated in BC tissues, and its overexpression significantly inhibited cell proliferation, migration, and invasion in vitro, as well as tumor growth in vivo. Furthermore, miR-17-5p was shown to be a direct target of HAND2-AS1, and it reversed the inhibitory effect of HAND2-AS1 on BC malignancies. Also, as a downstream factor of miR-17-5p, KLF9 silencing was demonstrated to mediate the role of miR-17-5p inhibitor in BC cell proliferation and invasion. Yes Results showed that HAND2-AS1 was downregulated in BC tissues, and its overexpression significantly inhibited cell proliferation, migration, and invasion in vitro, as well as tumor growth in vivo.Knockdown of HAND2-AS1 caused an opposite effect on BC cell malignancies. 35007433 HAND2-AS1 LncRNA Homo sapiens Osteosarcoma Tumor tissues and adjacent healthy tissues Expression[lower expressed] CCK8//qRT-PCR//Western Blot The results revealed that the expression levels of HAND2-AS1 were reduced in cancer tissues compared with those in healthy tissues. Yes HAND2-AS1-knockdown promoted osteosarcoma cell proliferation, increased glucose uptake and upregulated GLUT1 expression. 31423193 HAGLROS LncRNA Homo sapiens lung non-small cell carcinoma NSCLC tissues and cell lines Interaction(miR-100) Northern Blot//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Up-regulated HAGLROS expression was observed in NSCLC tissues and cell lines. HAGLROS repressed miR-100 expression to promote SMARCA5 expression in NSCLC cells, and miR-100 overexpression or SMARCA5 knockdown counteracted the oncogenic functions of HAGLROS. Yes Over-expressed HAGLROS promoted the malignant phenotypes of NSCLC cells; conversely, HAGLROS knockdown repressed the malignant phenotypes of NSCLC cells. 35307327 HAGLR LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Regulation[HOXD-AS1/miR-421/SOX4 axis ] qRT-PCR Our results revealed that HOXD-AS1 was upregulated in BCa tissues and cell lines, and high HOXD-AS1 expression was correlated with aggressive clinicopathological characteristics of BCa patients. Therefore, we shed light on that HOXD-AS1/miR-421/SOX4 axis may be considered as a novel therapeutic target for the treatment of BCa patients. Yes Further gain-of-function and loss-of-function analysis showed that HOXD-AS1 overexpression promoted, whereas HOXD-AS1 knockdown inhibited BCa cell proliferation, cell cycle progression, migration, and invasion, indicating that HOXD-AS1 may function as a novel oncogene in BCa. 30730081 HAGLR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines interaction[miR-217] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The results demonstrated that HOXD?AS1 was upregulated in CRC tissues and cell lines, and that overexpression of HOXD?AS1 was associated with poor prognosis in patients with CRC.Mechanistically, HOXD‑AS1 functioned as a competing endogenous RNA for miR‑217. The results demonstrated that HOXD?AS1 was upregulated in CRC tissues and cell lines, and that overexpression of HOXD?AS1 was associated with poor prognosis in patients with CRC. Yes Furthermore, knockdown of HOXD?AS1 inhibited cell proliferation, cell invasion, epithelial?mesenchymal transition and stem cell formation in vitro, as well as tumor growth and metastasis in vivo. 29749477 HAGLR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[miR-526b-3p/CCND1 Axis] CCK8//qRT-PCR//Western Blot//Transwell Assay HOXD-AS1 was highly expressed in CRC, and high expression of HOXD-AS1 was related to the poor prognosis of patients with CRC.HOXD-AS1 upregulated the expression of CCND1 to promote the proliferation, migration, and invasion of CRC through targeting miR-526b-3p. HOXD-AS1 was highly expressed in CRC, and high expression of HOXD-AS1 was related to the poor prognosis of patients with CRC. Yes Function experiment results revealed that miR-526b-3p inhibitor could reverse the suppressive effect of HOXD-AS1 knockdown on the proliferation, migration, and invasion of CRC cells. 32640404 H19 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[H19/miR-152-3p/TCF4 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay In vitro, we observed that H19 was overexpressed in GC tissues and cell lines.The H19/miR-152/TCF4 axis may provide a new perspective for treating GC. Yes After knockdown of H19, the IC50 of ADM was decreased and cell apoptosis rates increased in both BGC-823ADM and MGC-803ADM cells. 35117758 H19 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Regulation(Wnt/β-catenin signaling) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//IF//Luciferase Report Assay//IHC//Bioinformatics Analysis//Transwell Assay H19 was overexpressed in GC tissues and cell lines and related to poor prognosis for GC patients. Mechanistically, H19 could induce β-catenin to transfer into nucleus and activate Wnt/β-catenin signaling, thus promoting EMT and metastasis of GC cells. Yes In vitro and in vivo assays verified the promotion of H19 on GC cell epithelial to mesenchymal transition (EMT) and metastasis. 34348271 H19 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines Interaction[miR-138] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay We found that H19 was upregulated in breast cancer tissues and cells and associated with poor prognosis. Additionally, miR-138 was identified as a direct target of H19 and SOX4; overexpression of miR-138 inhibited the proliferation, invasion and migration of MDA-MB-231 and MCF-7 cells, but promoted apoptosis, which were abrogated by SOX4 overexpression. Downregulated miR-138 induced cell proliferation, invasion and migration, but inhibited apoptosis of MDA-MB-231 and MCF-7 cells, which were promoted by SOX4 overexpression. In addition, miR-138 overexpression reversed the effects of H19 in breast cancer cells; silencing of H19 inhibited tumor growth and downregulate EMT markers in vivo. Yes Downregulated H19 suppressed the proliferation, invasion and migration of breast cancer cells, but promoted cell cycle arrest and apoptosis. 31217890 H19 LncRNA Homo sapiens Breast Neoplasms cell lines Interaction[binds miR-93-5p to regulate STAT3] Western Blot//CCK8//RIP//qRT-PCR//Luciferase Report Assay "The results showed that the expression level of STAT3 in MDA‐MB‐231 cells was higher than that in MCF‐7 cells (Figure 1).Our study revealed a new network in the expression of STAT3 involving H19 and miR-93-5p, which may contribute to a better understanding of breast cancer pathogenesis and provide new insights into the treatment of this disease." Yes overexpression of H19 promoted proliferation, migration, and invasion, whereas knockdown of H19 reduced proliferation, migration, and invasion in vitro. 30256448 H19 LncRNA Homo sapiens Breast Neoplasms cancer tissues and cancer cell lines regulation[H19-miR-130a-3p-SATB1 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We demonstrated that H19 expression was higher in cancer tissues and cancer cell lines than in adjacent non-tumor tissues and normal cell lines, respectively. Our data uncovered a novel mechanism of BC progression based on the H19-miR-130a-3p-SATB1 axis. Yes H19 silencing inhibited the proliferation, migration and invasion of BC cells, and induced apoptosis. 33324070 H19 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[miR-203] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay It was found that compared with normal adjacent tissues, H19 expression was elevated in NSCLC tissues along with a decreased miR-203 expression level. It was also found that patients who were in advanced clinical stages had a higher H19 and a lower miR-203 expression compared to normal tissues. The overall survival time of patients with higher H19 expression was shorter compared with the lower H19 expression group. Yes Upregulation of A549 enhanced cell proliferation and promoted invasion. 30214583 H19 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell lines Interaction[inhibiting miR-200a] RNA Pull-Down//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay H19 expression was elevated in the lung cancer tissues and cell lines.Meantime, RNA pull-down assay showed that H19 interacted with miR-200a, and miR-200a inhibited the activity of H19-fused luciferase. Furthermore, H19 overexpression inhibited miR-200a function and thereby upregulated miR-200a target genes, ZEB1 and ZEB2.H19 sponged and inhibited miR-200a to de-repress expression of ZEB1 and ZEB2, and thereby enhanced lung cancer proliferation and metastasis. Yes H19 overexpression promoted the lung cancer cell growth, cell migration and invasion, as well as the epithelial mesenchymal transition (EMT). 31187349 H19 LncRNA Homo sapiens Colorectal Neoplasms interaction[binding to hnRNPA2B1] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Transwell Assay We found the expression of lncRNA H19 was significantly upregulated in primary tumor and metastatic tissues, correlated with poor prognosis in CRC.Our findings demonstrate the role of H19/hnRNPA2B1/EMT axis in regulation CRC metastasis, suggested H19 could be a potential biomarker to predict prognosis as well as a therapeutic strategy for CRC. Yes Ectopic H19 expression promoted the metastasis of colorectal cancer cells in vitro and in vivo, and induced epithelial-to-mesenchymal transition (EMT). 32698890 H19 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[regulating microRNA-22 via EMT pathway] CCK8//qRT-PCR//Western Blot LncRNA H19 was highly expressed in HBV-related HCC tissues.Western blot results demonstrated that lncRNA H19 remarkably decreased the protein expressions of EMT pathway-related genes, including N-cadherin, Vimentin, β-catenin and MMP-9. In addition, rescue experiments demonstrated that lncRNA H19 remarkably promoted malignant development of HBV-related HCC via regulating microRNA-22. The expression of lncRNA H19 was positively correlated with lymph node metastasis and distant metastasis, whereas negatively correlated with the overall survival of HBV-related HCC patients. Yes Results of in vitro experiments showed that lncRNA H19 knockdown significantly downregulated cell proliferation and invasion. 31298392 H19 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Regulation[H19/miR-326 axis] qRT-PCR We found that H19 was significantly elevated and miR-326 was decreased in HCC cells including Hep3B, HepG2, MHCC-97L, SK-hep1, Hun7, SMCC-7721 compared with LO2 cells, respectively. H19 downregulation can increase miR-326 expression in HCC cells. Meanwhile, miR-326 mimics can also inhibit HCC progression, whereas miR-326 inhibitors exhibited a reverse phenomenon by modulating H19 expression. In addition, a negative association between H19 and miR-326 was predicted and confirmed. Furthermore, the transcription factor TWIST1 has been recognized as a significant regulator in tumor progression. Here, by performing bioinformatics analysis, TWIST1 was identified as a downstream target of miR-326. The findings of our study implied that lncRNA H19 can serve as a ceRNA to sponge miR-326 and modulate TWIST1 levels in HCC pathogenesis. Taken these together, these findings indicated that H19/miR-326/TWIST1 axis was involved in HCC development and can indicate a novel HCC target. Yes In the subsequent experiments, we observed that inhibition of H19 can repress HCC cell growth, migration, and invasion in vitro. 30362512 H19 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Regulation[miR-15b/CDC42/PAK1 axis] IHC//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Colony Formation Assay//Transwell Assay H19 and CDC42 were up-regulated while miR-15b was down-regulated in HCC cells and tissues.miR-15b interacted with H19 and CDC42 3'-UTR. H19 knockdown suppressed CDC42/PAK1 pathway and EMT progress. Yes H19 knockdown inhibited proliferation, migration and invasion, and increased apoptosis, which was rescued by miR-15b inhibitor. 30543848 H19 LncRNA Homo sapiens Carcinoma, Hepatocellular human hepatoma cells Expression(highly expressed) CCK8//qRT-PCR//Western Blot The NR2F1-AS1 and H19 levels were high in human hepatoma cells, and AUCs of lncRNA NR2F1-AS1 and lncRNA H19 were both >0.8. The lncRNA NR2F1-AS1 and lncRNA H19 were associated with HCC staging. Yes After transfection of pcDNA3.1-NR2F1-AS1, si-NR2F1-AS1, NC, pcDNA3.1-H19, si-H19 BEL-7402 and Huh-7 cells, silencing NR2F1-AS1 and H19 expression can promote apoptosis and inhibit cell growth, while silencing their over-expression can inhibit the EMT process of Huh-7 cells. 33568940 H19 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC patients Expression(highly expressed) qRT-PCR Circulating lncRNA-H19 levels were significantly increased in HCC patients in both cohorts (p = .013; p < .0001). EpCAM+ CD133+ cells showed a stem cell-like phenotype, self-renewal capacity, upregulation of pluripotent gene expression and overexpressed lncRNA-H19 (p < .001). In addition, lncRNA-H19 levels increased accordingly with BCLC staging (p < .0001) and decreased after a partial and complete therapeutic response (p < .05). Yes Suppression of lncRNA-H19 by antisense oligonucleotide treatment significantly reduced the self-renewal capacity (p < .001). EpCAM, CD133 and lncRNA-h19 expression increased accordingly with disease progression in HFHCC-fed mice (p < .05) and also in liver tissue from HCC patients (p = .0082). 35243752 H19 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(microRNA-140/Wnt1 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay H19 expression was upregulated in OC tissues and cells, and its overexpression was associated with a poor prognosis of OC. H19 upregulated Wnt1 expression through targeting miR-140 in OC cells. H19 expression was upregulated in OC tissues and cells, and its overexpression was associated with a poor prognosis of OC. Yes si-H19 remarkably reduced OC cell proliferation and migration. H19 upregulated Wnt1 expression through targeting miR-140 in OC cells. 34002485 H19 LncRNA Homo sapiens Ovarian Neoplasms OC patients and cell lines Interaction(miR-140-5p/PI3K/AKT signaling pathway) Western Blot//Wound Healing Assay//Flow Cytometry//MTT//Transwell Assay H19 was highly expressed while miR-140-5p was lowly expressed in OC patients and cell lines (P < 0.050). Online prediction and dual-luciferase reporter (DLR) confirmed that H19 directly binds miR-140-5p. Western blot assay indicated overexpression activated the PI3K/AKT signaling pathway in OC cells. Yes The proliferation, invasion, migration ability, and epithelial-mesenchymal transition (EMT) of OC cells were reduced after inhibiting H19 expression, and the apoptosis rate was increased. Transfection of cells with miR-140-5p mimics brought opposite effects. 34250088 H19 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and human OC cell lines Expression(highly expressed) qRT-PCR//Wound Healing Assay//Invasion Assay//Transwell Assay H19 is upregulated remarkably in primary OC tissues and human OC cell lines (OVCAR3, SKOV3, A2780, and Caov-3). We found that the median PFS was longer in patients with lower levels of H19 than in those with high levels, suggesting that overexpression of H19 was linked to poor prognosis in OC patients. Yes Intriguingly, the depletion of H19 expression induced by small interfering RNA inhibited the capability of migration and invasion of OC cell lines. Restoration of H19 in OC cell lines significantly increased cell migration and invasion. 35072217 H19 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissue Expression [highly expressed] qRT-PCR H19 expression level was significantly higher in bladder cancer tissue compared to adjacent tissues (p< 0.05), and is correlated with advanced clinical stage (p< 0.05). In those metastatic patients, H19 expression level is significantly higher than those without metastasis (p< 0.05). H19 expression level was significantly higher in bladder cancer tissue compared to adjacent tissues (p< 0.05), and is correlated with advanced clinical stage (p< 0.05). In those metastatic patients, H19 expression level is significantly higher than those without metastasis (p< 0.05). H19 expression is up-regulated in bladder cancer, and is probably related with cancer clinical stage and metastasis. Yes RNA interference is applied to knockdown H19 expression in bladder cancer cell, and found potentiated E-cadherin expression (p< 0.05), accompanied with weakened metastatic potency (p< 0.05). Cell transfection reveals up-regulation of E-cadherin expression in bladder cancer cells when H19 expression is suppressed, accompanied with weakened metastasis potency. 29614625 H19 LncRNA Homo sapiens Osteosarcoma OS and corresponding normal adjacent tissue Interaction(miR‑29a‑3p/LASP1 ) qRT-PCR//Wound Healing Assay//Transwell Assay H19 was found to be overexpressed in OS compared with corresponding normal adjacent tissue. In addition, H19 served as a competing endogenous ncRNA targeting microRNA‑29a‑3p and activating LIM and SH3 domain protein 1 and modulating the OS cell phenotype. Yes In addition, H19 served as a competing endogenous ncRNA targeting microRNA‑29a‑3p and activating LIM and SH3 domain protein 1 and modulating the OS cell phenotype. 34328197 H19 LncRNA Homo sapiens Osteosarcoma tumor tissue Regulation [ p‑PI3K and p‑AKT] qRT-PCR//Western Blot Expression level of H19 was significantly elevated in tumor tissue compared with adjacent healthy tissue. Significantly decreased levels of p‑PI3K and p‑AKT, and elevated level of IκBα were observed in H19 knockdown osteosarcoma cells compared with control osteosarcoma cells, while no significant differences in levels of PI3K and AKT were observed. Therefore, the present study demonstrated that knockdown of lncRNA H19 can inhibit migration and invasion of human osteosarcoma cells by inhibiting the nuclear factor-κB pathway. Expression level of H19 was positively associated with distant metastasis of osteosarcoma (P<0.01), but not with gender and age. Overall survival of patients with osteosarcoma with high H19 level was significantly shorter compared with patients with low H19 expression (P<0.05). Yes H19 knockdown significantly reduced migration and invasion ability of osteosarcoma cells. 29568924 H19 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[NF-κB] Western Blot//CCK8//qRT-PCR//ELISA//Transwell Assay H19 expression was upregulated in H. pylori-infected GC tissues and cells.Moreover, H19 overexpression promoted the proliferation, migration and invasion of H. pylori-infected GC cells via enhancing NF-κB-induced inflammation. Yes Moreover, H19 overexpression promoted the proliferation, migration and invasion of H. pylori-infected GC cells via enhancing NF-κB-induced inflammation. 31787851 H19 LncRNA Homo sapiens Stomach Neoplasms GC primary tumor and para-cancerous tissues,cell lines(AGS,GES-1) Regulation[H19/miR‑22‑3p/Snail1 axis ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results revealed that H19 expression was significantly upregulated, whereas the expression level of miR-22-3p was decreased in the GC tissues compared with the para-cancerous tissues .In summary, these findings provide novel insight into the potential regulatory roles of H19 in GC, and suggest that the H19/miR‑22‑3p/Snail1 axis may prove to be a promising therapeutic target for the treatment of patients with GC. Yes Furthermore, the downregulation of H19 suppressed the proliferation, invasion, migration and epithelial‑mesenchymal transition of GC cells in vitro and suppressed tumor growth in vivo. 31081061 H20 LncRNA Mus musculus Aortic Aneurysm, Abdominal AAA tissues Interaction[H19/let-7a/IL-7] Western Blot//qRT-PCR//Luciferase Report Assay//ELISA//IHC qRT-PCR detected the upregulation of H19 in human and mouse AAA tissue samples.In vivo overexpression of H19 increased vascular inflammation and induced AAA formation, which was supported by exacerbated aortic morphology, maximum aortic diameter values, elastin degradation, expression of interleukin-6 (IL-6) and macrophage chemoattractant protein-1 (MCP-1), and macrophage infiltration. H19 suppression resulted in the opposite effects. A rescue experiment indicated that IL-6 neutralization significantly mitigated the aortic inflammation and AAA formation evoked by H19 overexpression. Luciferase reporter assays and ex vivo experiments using VSMCs and macrophages confirmed that H19 induced aneurysm formation in part via endogenous competition with the let-7a microRNA to induce the transcription of its target gene, IL-6. This mechanism was further validated by in vivo experiments using a mutant H19 that could not effectively bind let-7a. Collectively, our study revealed a pathogenic H19/let-7a/IL-6 inflammatory pathway in AAA formation, which offers a new potential therapeutic strategy for AAA. Yes In vivo overexpression of H19 increased vascular inflammation and induced AAA formation, which was supported by exacerbated aortic morphology, maximum aortic diameter values, elastin degradation, expression of interleukin-6 (IL-6) and macrophage chemoattractant protein-1 (MCP-1), and macrophage infiltration. 30991034 HAGLR LncRNA Homo sapiens Uterine Cervical Neoplasms CESC cells and tissues Interaction(ELF1/FRRS1) In Vivo Experiment//Western Blot//Transfection//CCK8//Flow Cytometry//RIP//qRT-PCR//IHC//EdU Staining HOXD-AS1 and FRRS1 were overexpressed in CESC. HOXD-AS1 elevated the level of FRRS1 by binding ELF1. Furthermore, HOXD-AS1 contributed to the CESC growth in mouse models. HOXD-AS1 promotes CESC by up-regulating FRRS1 via ELF1. Yes After transfection of sh-HOXD-AS1, sh-ELF1 or sh-FRRS1, the proliferation of SiHa and Hela cells was inhibited and their apoptosis was promoted; while HOXD-AS1 overexpression had opposite effects on CESC development.Co-transfection of sh-FRRS1 and pCDNA3.1-HOXD-AS1 could abolish the tumor suppressive effect of FRRS1 knockdown. 34985386 HAGLR LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues and cells regulation[miR-185-5p/CDK4/CDK6 axis] Western Blot//CCK8//qRT-PCR//EdU Staining//Transwell Assay Compared with normal colon cancer tissues and cells, the expression of HAGLR was increased in colon cancer tissues and cells. Lnc HAGLR promoted the development of colon cancer by miR-185-5p/CDK4/CDK6 axis, and lnc HAGLR might be potential target for colon cancer. Yes In addition, the expression of HAGLR down-regulation inhibited the growth, migration, and invasion of colon cancer cells. 32606801 HAGLR LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC cells and tissues Interaction[HOXD-AS1/miR-186-5p/PIK3R3 pathway] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Microarray//Transwell Assay HOXD-AS1 was found to be significantly over-expressed in EOC tumors. The novel HOXD-AS1/miR-186-5p/PIK3R3 pathway was clinically relevant as we observed a significantly inverse correlation between HOXD-AS1/miR-186-5p and between miR-186-5p/PIK3R3 in an independent cohort of 200 EOC tissues. Yes SiRNA inhibition of HOXD-AS1 reduced cell migration, invasion, and epithelial-mesenchymal transition (EMT) in EOC cells in vitro by preventing HOXD-AS1 directly binding to miR-186-5p, and resulting in down-regulating of PIK3R3. 30823895 HAGLR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[MEK/ERK pathway] qRT-PCR//Western Blot The Cancer Genome Atlas data analysis and experimental validation showed that HOXD-AS1 was increased in HCC tissues/cell lines and positively relevant to histologic grade. In vitro loss-of-function experiments revealed that silencing of HOXD-AS1 could dramatically suppress the proliferation, migration, and invasion, and induce S or/and G2/M phase cell cycle arrest as well as apoptosis of Bel-7402 and MHCC97H cells accompanying the changes in expression levels of cyclin B1, cyclin D1, BCL-2, BAX, and MMP2. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis indicated that HOXD-AS1 has the potential to affect p53, tumor necrosis factor (TNF), mitogen-activated protein kinase (MAPK) pathway, and Western blot results further validated that HOXD-AS1 silencing could inhibit the MEK/ERK pathway in Bel-7402 cells. Collectively, HOXD-AS1, as an oncogenic lncRNA, might exert crucial functions in HCC progression and serve as a potential diagnostic biomarker and therapeutic target for HCC. Yes In vivo assay also showed that HOXD-AS1 silencing could markedly reduce xenograft tumor volume and weight of HCC cells. 31231887 HAGLR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-6785-5p] qRT-PCR It was found that HAGLR level was higher in HCC tissues than paracancerous ones and correlated with rates of lymphatic metastasis and distant metastasis but not with age, gender, and tumor staging in HCC patients. LncRNA HAGLR stimulates proliferative and metastatic potentials in HCC via negatively regulating miR-6785-5p level, thus exacerbating the development of HCC. Survival analysis uncovered that HAGLR level was negatively linked to overall survival in HCC. Yes After knockdown of HAGLR, proliferative, and metastatic potentials in Bel-7402 and Hub7 cells were attenuated. 33015776 HAGLR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-326/SLC27A4] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Here, we elaborated that HOXD-AS1 was overexpressed in HCC tissues than that in the adjacent normal tissues and the level of HOXD-AS1 was related with the aggressive phenotypes of HCC. All these findings indicated that HOXD-AS1-miR-326-SLC27A4 axis participated into the progression of HCC. Yes Functionally, downregulation of HOXD-AS1 repressed the proliferation, invasion abilities of HCC cell in vitro and the distant metastasis of HCC cell in vivo. 32425696 HAGLR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells and tissues Interaction(miR-203a-5p) ISH//qRT-PCR//Transwell Assay//Western Blot HOXD-AS1 overexpression in OSCC predicted poor survival. HOXD-AS1 was predicted to interact with miR-203a-5p, but its expression was not significantly correlated with miR-203a-5p. HOXD-AS1 overexpression increased Annexin A4 expression, while miR-203a-5p overexpression decreased Annexin A4 expression in OSCC cells. Transwell assays showed that invasion and migration of OSCC cells were enhanced by HOXD-AS1 and Annexin A4 overexpression but were reduced by miR-203a-5p overexpression. In addition, miR-203a-5p overexpression suppressed the role of HOXD-AS1 in cell movement and Annexin A4 expression. HOXD-AS1 overexpression in OSCC predicted poor survival. Yes HOXD-AS1 overexpression increased Annexin A4 expression, while miR-203a-5p overexpression decreased Annexin A4 expression in OSCC cells. Transwell assays showed that invasion and migration of OSCC cells were enhanced by HOXD-AS1 and Annexin A4 overexpression but were reduced by miR-203a-5p overexpression. In addition, miR-203a-5p overexpression suppressed the role of HOXD-AS1 in cell movement and Annexin A4 expression. 35152529 HAGLR LncRNA Homo sapiens Osteosarcoma osteosarcoma tissue and cells interaction[p57,EZH2] Western Blot//CCK8//qRT-PCR//RIP//Cell Cycle Assay//ChIP Results revealed that HOXD-AS1 expression level was significantly up-regulated in osteosarcoma tissue and cells, moreover, the aberrant overexpression predicted the poor prognosis of osteosarcoma patients. In conclusion, our study confirmed that HOXD-AS1 could interact with EZH2, and then repress p57 expression, to aggravate osteosarcoma oncogenesis. which provide new idea for the osteosarcoma tumorigenesis. Results revealed that HOXD-AS1 expression level was significantly up-regulated in osteosarcoma tissue and cells, moreover, the aberrant overexpression predicted the poor prognosis of osteosarcoma patients. Yes Loss-of-functional experiments indicated that HOXD-AS1 silencing inhibited the osteosarcoma cells proliferation and induced G1/G0 phase arrest in vitro, and repressed tumor cell growth in vivo. 30119259 HAGLR LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines regulation[miR-877-3p/FGF2 axis] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay HOXD-AS1 was overexpressed in CC tissues and cell lines.HOXD-AS1 functions as a tumor-promoting lncRNA via the miR-877-3p/FGF2 axis in CC. Its higher level predicted worse prognosis of CC patients. Yes SiRNA mediated knockdown of HOXD-AS1 repressed CC cell migration and invasion, and its overexpression did the opposite. 32977766 HAGLR LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Interaction(miR-93-5p/SRSF1 axis) RNA Pull-Down//Western Blot//Tunel//qRT-PCR//FISH//IF//Luciferase Report Assay//Colony Formation Assay//Transwell Assay HAGLR was found to be highly expressed in TNBC tissues and cells, and inhibiting HAGLR suppressed cell proliferation, migration, and invasion and promoted cell apoptosis in TNBC. Meanwhile, miR-93-5p was shown to bind to HAGLR and SRSF1. In addition, SRSF1 plays an oncogenic role in TNBC. Importantly, HAGLR could activate the Wnt signaling pathway by sponging miR-93-5p to upregulate SRSF1; thus, accelerating TNBC progression. Yes HAGLR was found to be highly expressed in TNBC tissues and cells, and inhibiting HAGLR suppressed cell proliferation, migration, and invasion and promoted cell apoptosis in TNBC. 34128362 HAGLR LncRNA Rattus norvegicus Neuralgia CCI rats and SH-SY5Y cells Interaction(miR-182-5p/ATAT1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//FISH//qRT-PCR//Luciferase Report Assay//ELISA HAGLR displayed high levels in spinal cords of CCI rats and in LPS treated SH-SY5Y cells.Mechanistically, HAGLR bound with miR-182-5p in SH-SY5Y cells. ATAT1 served as a target of miR-182-5p. HAGLR activated the NLRP3 inflammasome by ATAT1. Yes Knockdown of HAGLR inhibited inflammation and neuron apoptosis of LPS treated SH-SY5Y cells. 33626373 HAGLR LncRNA Homo sapiens Thyroid Neoplasms TC tumor tissues Expression [highly expressed] RNA Pull-Down//Western Blot//Transfection//MeRIP//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Invasion Assay IGF2BP2 was highly expressed in TC tumor tissues. IGF2BP2 knockdown weakened cell proliferative, migratory, and invasive abilities, and induced cell cycle arrest and cell apoptosis in TC cells. LncRNA HAGLR expression was markedly upregulated and positively associated with IGF2BP2 expression in TC tissues. IGF2BP2 knockdown reduced HAGLR expression and transcript stability in TC cells. Yes HAGLR overexpression weakened the effects of IGF2BP2 loss on cell proliferation, migration, invasion, apoptosis, and cell cycle progression in TC cells. HAGLR overexpression weakened the effects of IGF2BP2 loss on cell proliferation, migration, invasion, apoptosis, and cell cycle progression in TC cells. 34340128 HAGLR LncRNA Homo sapiens Thyroid Cancer, Papillary papillary thyroid cancer tissues and cell lines Expression[highly expressed] qRT-PCR The results showed HOXD-AS1 is overexpressed in papillary thyroid cancer tissues and cell lines compared with matching nontumor tissue specimens and normal thyroid cell line, respectively. High expression of HOXD-AS1 was associated with elderly people, advanced clinical stage, large tumor size, present lymph node metastasis, and distant metastasis. Yes The study in vitro suggested reduced HOXD-AS1 expression inhibited papillary thyroid cancer cell proliferation, migration, and invasion, and promoted cell-cycle arrest. 30317670 HAGLR LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells Interaction(miR-664b-3p/PLAC8 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay HOXD-AS1 was significantly upregulated in PC tissues than in paired adjacent tissues. Mechanically, HOXD-AS1 upregulated PLAC8 by targeting miR-664b-3p. In conclusion, HOXD-AS1 was upregulated in PC tissues, promoting the proliferation, invasion, and migration of PC cells via the miR-664b-3p/PLAC8 axis. Moreover, HOXD-AS1 was related to the advanced TNM stage. Yes Meanwhile, HOXD-AS1 promoted the proliferation, invasion, and migration of PC cells. 35279480 HAGLR LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Expression[lower expressed] Western Blot//CCK8//qRT-PCR//FISH//RIP//Microarray Here, we reported that HAGLR (also called HOXD-AS1) was frequently down-regulated in lung adenocarcinoma (LUAD) tissues.Mechanistically, HAGLR could physically interact with DNMT1, and recruit DNMT1 on E2F1 promoter to increase local DNA methylation. Here, we reported that HAGLR (also called HOXD-AS1) was frequently down-regulated in lung adenocarcinoma (LUAD) tissues, and decreased HAGLR expression was clinically associated with shorter survival of LUAD patients. Yes Preclinical studies using multiple LUAD cells and in vivo mouse model indicated that HAGLR could attenuate LUAD cell growth in vitro and in vivo. 31194977 HAGLR LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cells regulation[regulating miR-520c-3p/MYCN] qRT-PCR//Luciferase Report Assay//RIP//ChIP In this study, HOXD-AS1 expression was significantly upregulated in CCA tissues and cells compared with control groups, respectively.SP1/HOXD-AS1/miR-520c-3p/MYCN plays a vital role in initiation and progression of CCA, and HOXD-AS1 is expected to be an efficient biomarker and therapeutic target. Increased HOXD-AS1 was markedly correlated with lymph node invasion, advanced TNM stage and poor survival of CCA patients. Yes Functionally, gain- and loss-of-function experiments demonstrated that HOXD-AS1 facilitated tumor proliferation, migration, invasion, EMT, stemness and drug resistance in vitro and in vivo. 32857725 HAGLR LncRNA Homo sapiens Prostatic Neoplasms serum exosomes Interaction(miR-361-5p/FOXM1 axis) In Vivo Experiment//qRT-PCR Here, we discovered an exosomal lncRNA HOXD-AS1 is upregulated in castration resistant prostate cancer (CRPC) cell line derived exosomes and serum exosomes from metastatic PCa patients, which correlated with its tissue expression. This sheds a new insight into the regulation of PCa distant metastasis by exosomal HOXD-AS1 mediated miR-361-5p/FOXM1 axis, and provided a promising liquid biopsy biomarker to guide the detection and treatment of metastatic PCa. Yes Further investigation confirmed exosomal HOXD-AS1 promotes prostate cancer cell metastasis in vitro and in vivo by inducing metastasis associated phenotype. 34864822 HAGLR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Regulation[HOXD-AS1-HOXD3-Integrin β3 regulatory axis ] RNA Pull-Down//Western Blot//ISH//Wound Healing Assay//Colony Formation Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//IHC//Invasion Assay//ChIP We observed that HOXD-AS1 was located in the nucleus of CRC cells and that nuclear HOXD-AS1 was downregulated in most CRC specimens and cell lines.Mechanistic investigations revealed that HOXD-AS1 could suppress HOXD3 transcription by recruiting PRC2 to induce the accumulation of the repressive marker H3K27me3 at the HOXD3 promoter. Subsequently, HOXD3, as a transcriptional activator, promoted Integrin β3 transcription, thereby activating the MAPK/AKT signalling pathways. Yes HOXD-AS1 downregulation enhanced proliferation and migration of CRC cells in vitro and facilitated CRC tumourigenesis and metastasis in vivo. 30823921 HAGLR LncRNA Homo sapiens Dermatomyositis DM patients Interaction(RUNX3/Foxp3) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//H&E Staining HAGLR was up-regulated and Foxp3 was down-regulated in DM patients. Besides, RUNX3 protein levels were decreased in DM patients, while its mRNA levels did not change significantly. The proportion of Treg cells was down-regulated in DM patients. In addition, interference with HAGLR could increase the levels of Foxp3, RUNX3 protein level, and the proportion of Treg cells. Besides, there was an interaction between HAGLR and RUNX3. We also found that knockdown of HAGLR and RUNX3 restored the increased Treg cells induced by HAGLR knockdown alone. Interference with HAGLR could increase the protein levels of RUNX3, high levels of RUNX3 further promoted the expression of the Foxp3, thus restoring the number of Treg cells and easing the development of DM. Yes In vivo experiments indicated that injection with adv-HAGLR increased Treg cell proportion and attenuated DM development. 35064420 GNAS-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma nasopharyngeal carcinoma cells regulation[Wnt/β-catenin pathway] CCK8//qRT-PCR//Western Blot//Transwell Assay GNAS-AS1 was upregulated in NPC. GNAS-AS1 exerted its function by regulating Wnt/β-catenin pathway. GNAS-AS1 functioned as an oncogenic role via mediating β-catenin expression. Yes GNAS-AS1 promoted cell proliferation, cell migration, and cell invasion in vitro. 32271425 GNAS-AS1 LncRNA Homo sapiens Keloid keloid clinical tissues and HKF cells Interaction( miR-188-5p/RUNX2 axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay GNAS-AS1 and RUNX2 expressions were remarkably enhanced, and miR-188-5p expression was decreased in keloid clinical tissues and HKF cells. GNAS-AS1 targeted miR-188-5p to regulate RUNX2 expression. In addition, the inhibition effects of GNAS-AS1 knockdown on HKF cells could be reversed by inhibition of miR-188-5p or overexpression of RUNX2, while RUNX2 overexpression eliminated the suppressive efficaciousness of miR-188-5p mimics on HKF cells growth. GNAS-AS1 knockdown could regulate the miR-188-5p/RUNX2 signaling axis to inhibit the growth and migration in keloid cells. Yes GNAS-AS1 overexpression promoted cells proliferation, migration, and invasion, while GNAS-AS1 knockdown had the opposite trend. Furthermore, overexpression of GNAS-AS1 reversed the inhibitory effect of 5-FU on cell proliferation, migration, and invasion. MiR-188-5p inhibition or RUNX2 overexpression could enhance the proliferation, migration, and invasion of HKF cells. 36036334 GNAS-AS1 LncRNA Homo sapiens Breast Neoplasms ER+ breast cancer tissues and cell lines regulation[miR-433-3p/GATA3 axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay//Transwell Assay The expression of GNAS-AS1 was obviously increased in ER+ breast cancer tissues and cell lines, as well as M2 macrophages. GNAS-AS1/miR-433-3p/GATA3 axis promoted proliferation, metastasis of ER+ breast cancer cells by accelerating M2 macrophage polarization. Yes GNAS-AS1 facilitated the capabilities of proliferation, migration and invasion of ER+ breast cancer cells by accelerating M2 macrophage polarization via directly sponging miR-433-3p. 32538432 GAS5 LncRNA Homo sapiens Endometrial Neoplasms endometrial carcinoma tissue Regulation[GAS5/miR-222-3p/p27 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay In this work, we found that lncRNA GAS5 was under-expressed in the endometrial carcinoma tissue specimens, especially these samples with type 2 diabetes mellitus. In conclusion, these results confirmed the vital regulation of GAS5/miR-222-3p/p27 axis in the endometrial carcinoma tumorigenesis. Besides, the aberrant under-expression of GAS5 was correlated with the advanced tumor stage as well as poor prognosis outcome. Yes Enforced GAS5 expression repressed the tumor phenotype of endometrial carcinoma cells, including proliferation and invasion. 31105847 GAS5 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines regulation[ miR-23a-3p/PTEN/PI3K/AKT Pathway] qRT-PCR//RNA Pull-Down//RIP In this study, we found that GAS5 was downregulated in human osteosarcoma tissues and cell lines compared with matched adjacent tissues and normal osteoblast cells.In summary, GAS5 functions as a competing endogenous RNA, sponging miR-23a-3p, to promote PTEN expression and suppress cell growth and invasion in osteosarcoma by regulating the PI3K/AKT pathway. Yes Overexpression of GAS5 could significantly suppress the growth and invasion of osteosarcoma cells, while downregulation of GAS5 promoted cell proliferation and invasion. 33121268 GAS5 LncRNA Homo sapiens Osteosarcoma OS tissues and cells regulation[miR-663a/RHOB axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The GAS5 expression level was significantly decreased in OS tissues and cells compared with normal tissues and cells, and could negatively regulate miR-663a expression.To sum up, we showed lncRNA GAS5 regulates OS progression via regulating the miR-663a/RHOB axis. Yes Overexpression of GAS5 and RHOB suppresses, while overexpression of miR-663a stimulates, OS cell proliferation, migration, and invasion in vitro. 32982421 GAS5 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//EdU Staining//Western Blot The expression of GAS5 was decreased and methylation state of GAS5 was elevated in cervical cancer. Yes Overexpression of GAS5 inhibited proliferation, cell cycle progression, invasion, migration while inducing apoptosis of cervical cancer cells as well as suppressed tumor growth and metastasis in nude mice. 31206689 GAS5 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] qRT-PCR//Transwell Assay The results showed that GAS5 was significantly (p < 0.05) downregulated in human cervical cancer tissues. Yes The transwell assays showed that GAS5 overexpression significantly (p < 0.05) inhibited the migration and invasion of the C33A and HeLa cervical cancer cells. 32105659 GAS5 LncRNA Homo sapiens Glioma Regulation[miR-18a-5p] ISH//qRT-PCR Taken together, our findings suggest that GAS5 is a tumor suppressor in human gliomas that acts in part by repressing miR-18a-5p. Yes In this study, we demonstrated that overexpression of GAS5 inhibits malignant phenotypes in glioma cells, including proliferation, migration, and invasion, whereas GAS5 knockdown enhances these phenotypes. 30078184 GAS5 LncRNA Homo sapiens Glioma glioma tissues interaction[targeting microRNA-106b ] Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Significant higher expression of miR-106b, and lower expression of GAS5 and PTEN in the glioma tissues were observed. GAS5 could regulate the EMT process, and the migration of gliomas cells through miR-106b targeting PTEN. Yes GAS5 could regulate the expression of PTEN through targeting miR-106b, and further influence EMT process, and the proliferation, migration, and invasion of gliomas cells. 32991951 GAS5 LncRNA Homo sapiens Glioma glioma cells regulation[GAS5/miR-424 signaling] Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay GAS5 and miR-424 were significantly down-regulated in glioma cells.GAS5, by inhibiting methylation and boosting expression of miR-424, inhibits AKT3 signaling and suppresses multiple malignant phenotypes. Yes Functionally, GAS5, by up-regulating miR-424, inhibited cell proliferation, migration, and invasion, while increased apoptosis of glioma cells in vitro, and suppressed xenograft growth in vivo. 32472311 GAS5 LncRNA Homo sapiens Glioma GSCs, glioma tissues Interaction(miR-23a/E-cadherin axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay In these, it was found that the lncRNA growth arrest-specific 5 (GAS5) expression was downregulated in GSCs and high-grade glioma tissues, compared with normal human astrocyte cells (NHAs) and normal brain tissues, respectively, which also showed a positive correlation with patient survival. Mechanistically, GAS5 directly sponged miR-23a, which in turn functioned as an oncogene by inhibiting E-cadherin, through the assays of reverse transcription-quantitative PCR (RT-qPCR) and luciferase reports. In addition, rescue experiments demonstrated that GAS5 could promote the expression and function of E-cadherin in a miR-23a-dependent manner. In these, it was found that the lncRNA growth arrest-specific 5 (GAS5) expression was downregulated in GSCs and high-grade glioma tissues, compared with normal human astrocyte cells (NHAs) and normal brain tissues, respectively, which also showed a positive correlation with patient survival. Yes Functional assays revealed that knocking down GAS5 expression promoted the proliferation, invasion, migration, stemness, and tumorigenicity of GSGs, while suppressing their apoptosis. 36460802 GAS5 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissue Interaction[silencing PTEN via EZH2] RNA Pull-Down//ChIP//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay Our results indicated that GAS5 expression was elevated in NPC tissues and cells. Moreover, GAS5 could epigenetically suppress PTEN expression via recruiting enhancer of zeste homolog 2 (EZH2). PTEN knockdown could reverse the inhibitory effect of GAS5 inhibition on NPC progression. Furthermore, GAS5 knockdown suppressed the tumor growth in vivo. In summary, knockdown of GAS5 repressed proliferation, migration and invasion, and promoted apoptosis in NPC through epigenetically silencing PTEN via recruiting EZH2. Yes GAS5 knockdown suppressed proliferation, migration and invasion, and induced apoptosis in NPC cells. 35527982 GAS5 LncRNA Homo sapiens Nasopharyngeal carcinoma nasopharyngeal carcinoma tissues and cells regulation[GAS5/miR-4465 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay We observed that the expression of lncRNA GAS5 was upregulated in nasopharyngeal carcinoma tissues and cells.The GAS5/miR-4465/COX2 axis in nasopharyngeal carcinoma pathogenesis was confirmed, which would provide a new therapeutic target for nasopharyngeal carcinoma. Yes Down-regulation of lncRNA GAS5 inhibited the proliferation and promoted apoptosis of nasopharyngeal carcinoma cells. 33092435 GAS5 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues Regulation(hsa-miR-1297) CCK8//qRT-PCR//Luciferase Report Assay//cell invasion assay//Bioinformatics Analysis "Compared to the adjacent nontumor tissues and the normal human intrahepatic biliary epithelial cell, the expression of GAS5 was markedly increased in CCA tissues (p<0.001) and cell lines (p<0.01), respectively. CCA patients with high GAS5 expression tended to present lymph node metastasis (p<0.001) and had advanced clinical stage (p=0.006). The bioinformatics analysis predicted that hsa-miR-1297 was the potential target gene of GAS5, which was validated by luciferase reporter assays. In addition, the function study showed that GAS5 acted as a ""sponge"" to downregulate hsa-miR-1297, thus modulating CCA cell proliferation and invasion." Compared to the adjacent nontumor tissues and the normal human intrahepatic biliary epithelial cell, the expression of GAS5 was markedly increased in CCA tissues (p<0.001) and cell lines (p<0.01), respectively. CCA patients with high GAS5 expression tended to present lymph node metastasis (p<0.001) and had advanced clinical stage (p=0.006). The bioinformatics analysis predicted that hsa-miR-1297 was the potential target gene of GAS5, which was validated by luciferase reporter assays. Yes The bioinformatics analysis predicted that hsa-miR-1297 was the potential target gene of GAS5, which was validated by luciferase reporter assays. 33790648 GAS5 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissue,cell lines Interaction[miR-21 ] CCK8//qRT-PCR//Western Blot This study demonstrated that GAS5 was significantly downregulated in LSCC tissue and human LSCC cell lines.GAS5 suppresses LSCC progression through the negative regulation of miR-21 and its targets involved in cell proliferation and apoptosis, indicating that GAS5 may serve as a biomarker and potential target for LSCC therapy. Yes In addition, the ectopic expression of GAS5 significantly inhibited cell proliferation and promoted apoptosis. 31572003 GAS5 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC cell lines Interaction(miR-26a-5p/ULK2) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis The expression level of GAS5 was frequently decreased in LSCC cell lines, and up-regulated GAS5 inhibited AMC-HN-8 cells viability and induced apoptosis. While down-regulated GAS5 had opposite results in Tu 177 cells, GAS5 was found to act as a microRNA sponge in a pathway to regulate miR-26a-5p and its target gene ULK2. Yes The expression level of GAS5 was frequently decreased in LSCC cell lines, and up-regulated GAS5 inhibited AMC-HN-8 cells viability and induced apoptosis. More importantly, we found that GAS5 activated autophagy, with enhanced autophagy-related proteins after GAS5 overexpression. 33551645 GAS5 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Expression[lower expressed] Flow Cytometry//qRT-PCR//MTT//Transwell Assay GAS5 was down-regulated in PCa tissues and cells. Yes GAS5 overexpression suppressed cell viability and migration while facilitated radiosensitivity of PCa cells. 33061579 GAS5 LncRNA Homo sapiens Melanoma melanoma tissues regulation[EZH2,CDKN1C] qRT-PCR//RNA Pull-Down//RIP High expression of EZH2 and poor expression of lncRNA GAS5 and CDKN1C was observed in melanoma tissues and found to be correlated with the reduction in survival expectancy of melanoma patients.The evidence provided by our study highlighted the involvement of lncRNA GAS5 in the translational suppression of EZH2 as well as the upregulation of CDKN1C, resulting in the promotion of melanoma cell apoptosis and oxidative stress. Yes Overexpression of lncRNA GAS5 or CDKN1C or EZH2 knockdown could inhibit cell viability but enhance melanoma cell apoptosis and oxidative stress. 32308561 GAS5 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and TAM Interaction( miR-21-PTEN-AKT AND YAP1) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//IHC Quantitative PCR results showed that GAS5 expression decreased in EC tissues and primary TAMs from EC tumors. These antitumor effects of GAS5 on TAMs were mediated by the activation of the miR-21-PTEN-AKT pathway and inhibition of YAP1. Yes "Direct coculture of GAS5-overexpressing TAMs and EC cells showed that GAS5 enhanced phagocytosis, antigen presentation, and activation of cytotoxic T cells, and repressed ""Don't eat me"" signals between TAMs and EC cells. Tumor formation in immunodeficient mice showed that GAS5-overexpressing macrophages could repress EC formation in vivo." 35534987 GAS5 LncRNA Homo sapiens Liver Neoplasms cell lines Interaction[ miR-544/RUNX3] RNA Pull-Down//Western Blot//qRT-PCR//RIP//ELISA Compared with a control group, lncRNA GAS5, RUNX3, and NCR1 were down-regulated in NK cells of patients with liver cancer, whereas miR-544 expression was up-regulated in NK cells of patients with liver cancer.Activated NK cells had higher IFN-γ level. Knockdown of GAS5 in activated NK cells decreased IFN-γ secretion, NK cell cytotoxicity, the percentage of CD107a+ NK cells, and the apoptosis rate of HepG2 and Huh7 cells. We also proved the interaction of GAS5 and miR-544, and the negative regulation role of GAS5 on miR-544. GAS5 overexpression in activated NK cells increased RUNX3 expression, IFN-γ secretion, the NK cell cytotoxicity, the percentage of CD107a+ NK cells, and the apoptosis rate of HepG2 cells, while miR-544 mimic abolished the promotion effect of GAS5 overexpression. Yes Finally, in vivo experiments indicated an inhibition effect of GAS5 in tumor growth. 30774011 GAS5 LncRNA Homo sapiens Laryngeal Neoplasms 40 paired laryngeal cancer tissues and adjacent normal tissues Interaction(PI3K/AKT/mTOR Signaling Pathway) Western Blot//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Transwell Assay In the current study, lncRNA GAS5 was downregulated in laryngeal cancer tissues and its low expression was closely associated with poor tumor differentiation, advanced TNM stage, lymph node metastasis, and shorter overall survival time. Mechanistically, our data showed that the overexpression of lncRNA GAS5 significantly regulated the PI3K/AKT/mTOR signaling pathway. In the current study, lncRNA GAS5 was downregulated in laryngeal cancer tissues and its low expression was closely associated with poor tumor differentiation, advanced TNM stage, lymph node metastasis, and shorter overall survival time. Yes In addition, lncRNA GAS5 upregulation significantly inhibited laryngeal cancer cell proliferation both in vitro and in vivo. Moreover, in response to lncRNA GAS5 overexpression, more laryngeal cancer cells were arrested at the G2/M stage, accompanied by increased cell apoptosis rates and suppressed migration and invasion capacities. 33641529 GAS5 LncRNA Homo sapiens Osteosarcoma Osteosarcoma tissue,cell lines Interaction[CtBP1-HDAC1/2-IRF1 ] Western Blot//Co-IP//qRT-PCR//MTT//Microarray//ChIP Here, we discovered that GAS5 was downregulated in cancerous osteosarcoma tissues and cells. Yes Specifically, GAS5 overexpression in the U2OS osteosarcoma cell line induced TP53, Bax and Bim levels but inhibited DDB2, TGFB and ROS1 expression, resulting in the inhibition of cell proliferation, invasion, colony formation and in vivo tumor formation. 31337976 GAS5 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cell lines(HSC3, HSC6, SCC15, SCC25, UM1, and Cal-27) Regulation[miR-21/PTEN axis] qRT-PCR//Wound Healing Assay//Transwell Assay Among the tested OSCC cells, GAS5 were relatively highly expressed in HSC6 and SCC25 cells, while low expressed in SCC15 and UM1 cells (Fig. 1A). Furthermore, miR-21 overexpression reversed the effect of GAS5. Western blot showed that knockdown of GAS5 suppressed PTEN, while phosphorylation of Akt was promoted. PCNA, cyclinD1, and Ki-67 were up-regulated, indicating enhanced proliferation. E-cadherin was down-regulated, while N-cadherin, vimentin, and snail1 were increased, indicating augmented epithelial-mesenchymal transition. Overexpression of GAS5 regulated these proteins inversely. Overexpression of miR-21 reversed the effect of GAS5 on these proteins. Taken together, GAS5 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition in OSCC through the miR-21/PTEN axis and might be a novel therapeutic target for OSCC. Yes qRT-PCR, cell viability, wound-healing, and transwell assays showed that knockdown of GAS5 increased miR-21 expression and promoted proliferation, migration, invasion, and epithelial-mesenchymal transition of OSCC cells.In contrast, overexpression of GAS5 showed the opposite effects. 30576678 GAS5-AS1 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-106b-5p/TUSC2 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay GAS5-AS1 expression was downregulated in glioma tissues and cells, and upregulation of GAS5-AS1 expression inhibited glioma cell proliferation, migration, and invasion. GAS5-AS1 expression was correlated with the glioma tumor grade.In summary, lncRNA GAS5-AS1 inhibited glioma proliferation, migration, and invasion by sponging miR-106b-5p and regulating the expression of TUSC2. Yes GAS5-AS1 expression was downregulated in glioma tissues and cells, and upregulation of GAS5-AS1 expression inhibited glioma cell proliferation, migration, and invasion. GAS5-AS1 expression was correlated with the glioma tumor grade. In nude mice, upregulation of GAS5-AS1 markedly suppressed glioma tumor growth. 32072565 GAS5 LncRNA Homo sapiens Urinary Bladder Neoplasms 50 pairs of BC tissues Interaction(miR-18a-5p/AXIN2/GSK3β axis) qRT-PCR//FISH We analyzed the expression of GAS5 in 50 pairs of BC tissues and found that GAS5 was low expressed in BC tissues compared with normal mucosal tissues. Chromatin isolation by RNA purification (ChIRP), RNA immunoprecipitation (RIP) and luciferase assay demonstrated the target binding relationship of GAS5 with miR-18a-5p. Rescue experiments demonstrated that GAS5 promoted the proliferation and migration of BC cells through target binding of miR-18a-5p. Moreover, miR-18a-5p bound to its targets AXIN2 and GSK3β, which in turn affected the expression of Wnt/β-catenin pathway-related proteins. Yes In vitro and in vivo experiments showed that GAS5 could affect the proliferation and migration of BC cells. 36331809 GAS5 LncRNA Homo sapiens Stomach Neoplasms GC tissues,cell lines Interaction[Akt/mTOR pathway] qRT-PCR//Luciferase Report Assay Herein, the decreased GAS5 and increased miRNA-106a-5p levels were observed in GC and cell lines. Taken together, our findings conclude the GAS5 overexpression suppresses tumorigenesis and development of gastric cancer by sponging miR-106a-5p through the Akt/mTOR pathway. Yes Functional experiments showed that GAS5 overexpression suppressed GC cell proliferation, migration and invasion capabilities, and promoted apoptosis, while miRNA-106a-5p overexpression inverted the functional effects induced by GAS5 overexpression. In vivo, GAS5 overexpression inhibited tumor growth by negatively regulating miRNA-106a-5p expression. 31182630 GAS5 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tisssues, cell lines interaction[p53 ] ISH//qRT-PCR//RNA Pull-Down//RIP GAS5 expression was markedly decreased in GC tissues and cell lines, and its low expression was strongly related to GC metastasis and unsatisfactory prognosis. GAS5 expression was markedly decreased in GC tissues and cell lines, and its low expression was strongly related to GC metastasis and unsatisfactory prognosis. Yes GAS5 overexpression repressed GC cell migration and invasion by targeting p53. 31530437 GAS5 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cells regulation[ miR-21] CCK8//qRT-PCR//Western Blot//Transwell Assay GAS5 was low expression and miR-21 was high expression in gastric cancer tissues and cells.miR-21 is a GAS5 target and GAS5 inhibits the proliferation of gastric cancer cells by targeting miR-21. Yes GAS5 overexpression reduced the proliferation, migration, and invasion of gastric cancer cells and increased the apoptosis of gastric cancer cells. 31910411 GAS5 LncRNA Homo sapiens Stomach Neoplasms GC cell lines Interaction(miR-34c ) Bioinformatics Analysis We revealed that lncRNA GAS5 regulates miR-34c by targeting E2F1. Additionally, we found that lncRNA GAS5, independently of p53, inhibits GC proliferation through the ATM/p38 MAPK signaling pathway. Accordingly, our results support that E2F1 is an engaging target of drug development in tumor growth and aggressive proliferation of GC, and favorable results can be achieved through tumor suppressor lncRNA GAS5/miR-34c axis in GC. Yes We revealed that lncRNA GAS5 regulates miR-34c by targeting E2F1. Additionally, we found that lncRNA GAS5, independently of p53, inhibits GC proliferation through the ATM/p38 MAPK signaling pathway. Accordingly, our results support that E2F1 is an engaging target of drug development in tumor growth and aggressive proliferation of GC, and favorable results can be achieved through tumor suppressor lncRNA GAS5/miR-34c axis in GC. 36316351 GAS5 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues regulation[regulating miR-216b] qRT-PCR//Luciferase Report Assay//Transwell Assay Compared with paracancerous tissues, in breast cancer tissues, the expression of GAS5 was increased and the expression of miR-216b was decreased. GAS5 can target on miR-216b to regulate the biological behavior and epithelial-mesenchymal transition of breast cancer cells. The expression of GAS5 in the tissues with lymph node metastasis of breast cancer was markedly increased. Yes The inhibition of GAS5 can promote the apoptosis of breast cancer cells; GAS5 can specifically bind to the 3' UTR of miR-216b. 32432750 GAS5 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-221-3p/IRF2 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay GAS5 expression was down-modulated in NSCLC tissues and cell lines. GAS5 overexpression restrained the proliferation, migration and invasion of NSCLC cells, while miR-221-3p, which was targeted and negatively modulated by GAS5, worked oppositely. Restoration of miR-221-3p markedly reversed the effects of GAS5 on NSCLC cells. Additionally, GAS5 increased IRF2 expression in NSCLC cells by repressing miR-221-3p. Yes GAS5 overexpression restrained the proliferation, migration and invasion of NSCLC cells, while miR-221-3p, which was targeted and negatively modulated by GAS5, worked oppositely. Restoration of miR-221-3p markedly reversed the effects of GAS5 on NSCLC cells. 34022918 GAS5 LncRNA Homo sapiens Lung Neoplasms cell lines Regulation[miR-205/PTEN Axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay The results indicated that GAS5 was drastically downregulated in lung cancer cell lines.The luciferase reporter assays determined that miR-205 was a direct target of GAS5 in lung cancer. Moreover, the Phosphatase and tensin homologue (PTEN) was known as a direct target of miR-205 and miR-205/PTEN rescued the effects of GAS5 in NSCLC cells. CONCLUSIONS To sum up, our results illustrate that upregulation of GAS5 in NSCLC suppresses its growth, migration, and invasion via the miR-205/PTEN axis. Yes Further functional analysis showed that down-expression of GAS5 remarkably induced NSCLC growth, migration, and invasion. 30926767 GAS5 LncRNA Homo sapiens Lung Neoplasms cell line Regulation qRT-PCR//IHC//Western Blot//Transwell Assay Cell invasion and migration were inhibited markedly in GAS5 overexpressed cell line. Cell cycle results indicated that the percentage of S-phase cells was increased,and G2-phase was reduced in the GAS5 overexpression cell line. Tumor size was suppressed obviously after GAS5 overexpression treatment. GAS5 markedly inhibited the expression of E-cadherin and induced the expression of N-cadherin. GAS5 overexpression significantly inhibited lung cancer cell proliferation by increasing the E-cadherin and decreasing N-cadherin. Yes Cell invasion and migration were inhibited markedly in GAS5 overexpressed cell line. Cell cycle results indicated that the percentage of S-phase cells was increased,and G2-phase was reduced in the GAS5 overexpression cell line. Tumor size was suppressed obviously after GAS5 overexpression treatment. GAS5 markedly inhibited the expression of E-cadherin and induced the expression of N-cadherin. GAS5 overexpression significantly inhibited lung cancer cell proliferation by increasing the E-cadherin and decreasing N-cadherin. 33976738 GAS5 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Regulation[Wnt/β-catenin signaling pathway] qRT-PCR//Western Blot Initially, poor expression of GAS5 was observed in CRC tissues and cells.Taken together, the results of the study conclude that lncRNA GAS5 inhibited the activation of the Wnt/β-catenin signaling pathway, thereby suppressing the angiogenesis, invasion, and metastasis of CRC. Yes Upregulated GAS5 repressed CRC cell invasion and migration in vitro, as well as subcutaneous tumor growth, angiogenesis, and liver metastases in vivo. 30672001 GAS5 LncRNA Homo sapiens Colorectal Neoplasms CRC patients and cell lines Interaction(miR‑34a/mTOR/SIRT1 pathway ) qRT-PCR//Western Blot Our results suggested that GAS5 was downregulated and acted as a molecular sponge of miR‑34a during CRC progression. miR‑34a participated in regulating GAS5‑suppressed CRC cell macroautophagy and induced apoptosis through the mTOR/SIRT1 pathway. Our results suggested that the GAS5/miR‑34a/SIRT1/mTOR negative regulatory feedback loop mediated CRC cell macroautophagy, and maintained the cells in an autonomous equilibrium state, but not excessive activation state, which functions as a strong antiapoptotic phenotype during human CRC progression. Yes GAS5‑mediated macroautophagy was maintained in an equilibrium state that might have a protective effect on CRC cell apoptosis. The mTOR signaling pathway suppressed GAS5 expression and formed a negative regulation feedback loop with miR‑34a in CRC cells. 33416133 GAS5 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-10b) CCK8//qRT-PCR The expression of GAS5 was downregulated in CRC tissues and cell lines. The overexpression of GAS5 can inhibit cell proliferation and progression, induce apoptosis in vitro, and inhibit the growth of CRC tumor in vivo. Yes The overexpression of GAS5 can inhibit cell proliferation and progression, induce apoptosis in vitro, and inhibit the growth of CRC tumor in vivo. 35103069 GAS5 LncRNA Homo sapiens Colorectal Neoplasms tumor tissues and CRC cells Interaction(miR-21/LIFR Axis) Transwell Assay//qRT-PCR//Luciferase Report Assay//Western Blot GAS5 was significantly decreased in tumor tissues and CRC cells, and the low expression of CAS5 in CRC promoted tumor metastasis and decreased the survival of patients.Furthermore, GAS5 increases the expression level of target gene LIFR to promote the apoptosis of CRC cells by binding to miR-21. Yes GAS5 knockdown increases the cell viability, inhibits apoptosis, and promotes migration. Xenografted tumors in nude mice studies showed that GAS5 knockdown promoted tumor growth and caused worse lesions in colorectal. 36062165 GAS5 LncRNA Homo sapiens Colorectal Neoplasms HCT116 cells Interaction(miR-21/PTEN/Akt axis) Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay These results indicated that inhibition of GAS5 up regulated the expression level of miR-21, promoted cell proliferation, invasion and migration, decreased G(1)-phase cells and increased S-phase cells, and suppressed cell apoptosis (P<0.05). Moreover, inhibition of GAS5 up regulated the expressions of Snail, N-cadherin, vimentin, Sox2, CD44, Oct2 and p-Akt in HCT-116 cells (P<0.05), while down regulated the expressions of E-cadherin and PTEN (P<0.05). Inhibition of miR-21 reversed the impact of GAS5 knockdown on PTEN/Akt signaling pathway (P<0.05). Yes These results indicated that inhibition of GAS5 up regulated the expression level of miR-21, promoted cell proliferation, invasion and migration, decreased G(1)-phase cells and increased S-phase cells, and suppressed cell apoptosis (P<0.05). Moreover, inhibition of GAS5 up regulated the expressions of Snail, N-cadherin, vimentin, Sox2, CD44, Oct2 and p-Akt in HCT-116 cells (P<0.05), while down regulated the expressions of E-cadherin and PTEN (P<0.05). Inhibition of miR-21 reversed the impact of GAS5 knockdown on PTEN/Akt signaling pathway (P<0.05). 36380665 GAS5 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC cells Regulation(IFN/STAT1) CCK8//qRT-PCR//Colony Formation Assay The results showed that upregulation of GAS5 significantly inhibited papillary thyroid cancer cell growth, migration and invasion in vitro. RNA transcriptome sequencing was performed to explore the underlying targets of GAS5. In this study, we confirmed a negative correlation between the GAS5 expression level and papillary thyroid carcinoma clinicopathologic characteristics, such as the tumor size, lymph node metastasis, the TNM stage and BRAFV600E mutation. Yes The results showed that upregulation of GAS5 significantly inhibited papillary thyroid cancer cell growth, migration and invasion in vitro. RNA transcriptome sequencing was performed to explore the underlying targets of GAS5. 35366462 GAS5 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue Interaction[Sponging miR-135b] qRT-PCR//Luciferase Report Assay//Western Blot//Transwell Assay Decreased GAS5 and increased miR-135b in HCC inversely correlate with each other and both correlate with poor prognosis of HCC patients.Mechanistically, GAS5 is a target of miR-135b. Furthermore, GAS5 positively regulates expression of RECK, also a target of miR-135b, which further inhibits MMP-2 expression and contributes to invasion repression. Yes Functionally, GAS5 suppresses while miR-135b promotes HCC cell invasion capacities in vitro. 30733959 GAS5 LncRNA Homo sapiens Ovarian Neoplasms OA tissues interaction[miR-196a-5p,HOXA5 ] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay LncRNA GAS5 depressed OA development by targeting miR-196a-5p and thereby down-regulating HOXA5 expression, providing substance for developing lncRNA-based strategies to treat OA. Lower GAS5 expression and higher miR-196a-5p expression were associated with larger tumor size (≥5 cm) and more advanced FIGO stage (III-IV) of OA patients (P < 0.05). Yes Transfection of si-GAS5, miR-196a-5p mimic or si-HOXA5 conferred OA cells with stronger viability, faster proliferation and smaller percentage of apoptosis (P < 0.05). After injecting mice models with si-GAS5, miR-196a-5p mimic or si-HOXA5, a larger tumor size was also observed within the rats (P < 0.05). 30201235 GAS5 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cell lines Regulation[GAS5/miR-21/SPRY2 signaling pathway] qRT-PCR//MTT//Western Blot It was identified that the expression levels of GAS5 and Sprouty homolog 2 (SPRY2) were significantly downregulated, while the expression level of microRNA (miR)-21 was significantly upregulated in ovarian cancer tissues and cell lines compared with adjacent non-tumor tissues and normal ovarian epithelial cells, respectively.Luciferase assay data indicated that miR-21 was a direct target of GAS5 and that SPRY2 was a target gene of miR-21 in ovarian cancer-derived A2780 cells. Yes GAS5 overexpression significantly inhibited the proliferation of ovarian cancer cells, which was accompanied by the downregulation of miR-21 and the upregulation of SPRY2. 29896229 GAS5 LncRNA Homo sapiens Ovarian Neoplasms OC samples and cell lines Interaction(miR-96-5p/PTEN axis) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//CCK8//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Microarray//Colony Formation Assay//Transwell Assay Our results demonstrated decreased expression levels of GAS5 and PTEN in OC samples and cell lines, while miR-96-5p was up-regulated when compared with the controls. GAS5 overexpression could significantly reduce OC cell proliferation and invasion ability via suppression of miR-96-5p expression. Moreover, GAS5 could influence the PTEN/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway. Yes GAS5 overexpression could significantly reduce OC cell proliferation and invasion ability via suppression of miR-96-5p expression. 35071464 GAS5 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder tissues regulation[ miR-21 and PTEN] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay The expression level of GAS5 was decreased and that of miR-21 was increased, indicating a negative correlation between the two. GAS5 could exert antiproliferative and proapoptotic effects on bladder cancer cells through miR-21 and PTEN. Patients with high GAS5 level and low miR-21 level had relatively longer survival rates. Yes GAS5 inhibited bladder cancer cells proliferation and promoted apoptosis, and miR-21 had the opposite effects. 32069387 GAS5 LncRNA Homo sapiens prostate carcinoma Tumor tissue and adjacent healthy tissue Interaction[Interact with MicroRNA-145] CCK8//qRT-PCR In the present study, miR-145 and lncRNA GAS5 expression levels were demonstrated to be Expression[down-expression]regulated in tumor tissues compared with adjacent healthy tissues of patients with prostate carcinoma. miR-145 and lncRNA GAS5 expression levels were found to be positively and significantly correlated in tumor tissues, but not in adjacent healthy tissues. Yes Overexpression of miR-145 and lncRNA GAS5 promoted apoptosis and inhibited cell proliferation in prostate carcinoma cell lines, whereas lncRNA GAS5 knockExpression[down-expression] had an opposite effect. In addition, lncRNA GAS5 knockExpression[down-expression] partially attenuated the effect of miR-145 overexpression of cancer cell proliferation and apoptosis. Therefore, miR-145 may inhibit cell proliferation and induce apoptosis in human prostate carcinoma by Expression[Expression[up-expression]-expression]regulating lncRNA GAS5. 31423164 GAS5 LncRNA Homo sapiens Myocardial Infarction post-MI myocardial cells Regulation[miR-525-5p/CALM2 axis] Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay Our data showed that the expression of GAS5 and CALM2 in PMMC was significantly upregulated, while the expression of miR-525-5p was downregulated.These data suggested that lncRNA GAS5 promoted the development and progression of MI via targeting of the miR-525-5p/CALM2 axis and it has the potential to be explored as a therapeutic target for the treatment of MI in the future. Yes Overexpression of GAS5 and CALM2 profoundly promoted the apoptosis of myocardial cell. However, the proliferation of myocardial cell was inhibited by the upregulation of GAS5 and CALM2. 31429119 GAS5 LncRNA Homo sapiens Sepsis THP-1 cells Interaction(miR‑23a‑3p/TLR4 ) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//ELISA//Bioinformatics Analysis The results revealed that LPS increased the expression of GAS5 in THP-1 cells, and GAS5 knockdown effectively inhibited inflammation and cell apoptosis in the LPS?induced sepsis model. In addition, the results of the luciferase reporter assays indicated that both GAS5 and TLR4 directly target miR‑23a‑3p. Yes The results revealed that LPS increased the expression of GAS5 in THP?1 cells, and GAS5 knockdown effectively inhibited inflammation and cell apoptosis in the LPS?induced sepsis model. 33982771 GAS5 LncRNA Homo sapiens Hepatoblastoma HCC tissues and cells Interaction( CHOP signal pathway) In Vivo Experiment//IHC//Western Blot//RIP//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay Lower expression levels of Gas5 were determined in HCC tissues and cells by quantitative reverse transcription-polymerase chain reaction.78 kDa glucose-regulated protein (GRP78) was identified as a direct target of Gas5 by Rip-qPCR and Western blot analysis assay. Further studies indicated that the knockdown of CHOP by shRNA partially reversed Gas5-mediated apoptosis in HepG2 cells. Yes Overexpressed Gas 5 lentiviral vectors were constructed to analyze their influence on cell viability, migration, invasion, and apoptosis. Gas5 inhibited HepG2 cell growth and induced cell apoptosis via upregulating CHOP to activate the ER stress signaling pathway. Magnetic resonance imaging showed that the ectopic expression of Gas5 inhibited the growth of HCC in nude mice. 34636091 Gas5 LncRNA Mus musculus Diabetic Cardiomyopathies heart tissues interaction[miR-34b-3p/AHR] qRT-PCR//ELISA//Luciferase Report Assay//Western Blot Compared with normal mice, GAS5 was severely down-regulated in heart tissues of DCM mice.In summary, our study demonstrates that GAS5 acts as a competing endogenous RNA to enhance AHR expression by sponging miR-34b-3p, which consequently represses NLRP3 inflammasome activation-mediated pyroptosis to improve DCM. Yes GAS5 overexpression improved cardiac function and myocardial hypertrophy in DCM mice. 33092444 Gas5 LncRNA Mus musculus renal fibrosis renal tissues Interaction[miR-96-5p] qRT-PCR In this study, the lncRNA GAS5 was upregulated in both TGF-β1-treated HK-2 cells and the kidneys of HDF/STZ mice.Knockdown of GAS5 relieved renal tubular epithelial fibrosis. This effect was mediated by the downregulation and functional inactivation of miR-96-5p. Furthermore, miR-96-5p was downregulated in DKD mice, and this downregulation attenuated the repression of FN1(fibronectin, FN) and led to its upregulation. The decrease in miR-96-5p was partially attributed to the miRNA-sponge action of GAS5.Our research demonstrates that knockdown of lncRNA GAS5 leads to antifibrosis by competitively binding miR-96-5p, which inhibits the expression of FN1. These results indicate that targeting lncRNA GAS5 may be a promising therapeutic strategy for preventing DKD. Yes Knockdown of GAS5 relieved renal tubular epithelial fibrosis. 31810140 Gas5 LncRNA Mus musculus Non-alcoholic Fatty Liver Disease HFD mice Interaction(microRNA-29a-3p/NOTCH2 axis) In Vivo Experiment//Western Blot//Transfection//RIP//qRT-PCR//Luciferase Report Assay//RNA-seq//H&E Staining//Oil Red O Staining//ELISA//IHC We showed that NAFLD activity score was elevated in the HFD mice. Moreover, GAS5 overexpression enhanced NOTCH2 levels in liver cells and promoted NAFLD progression by sponging miR-29a-3p in vivo. Furthermore, miR-29a-3p inhibited NAFLD progression by targeting NOTCH2 in vivo. Yes GAS5 knockdown attenuated HFD-induced hepatic steatosis and lipid accumulation and reduced NAFLD activity score in HFD mice. In addition, GAS5 knockdown reduced serum triglyceride cholesterol levels and inhibited alanine aminotransferase and aspartate aminotransferase activities in HFD mice. 35322757 Gas5 LncRNA Mus musculus Cerebral Infarction brain tissues Regulation[notch1 signaling pathway] qRT-PCR//Western Blot Reverse transcription-polymerase chain reaction (RT-PCR) showed that the lncRNA GAS5 expression in brain tissues of rats in CI group was significantly higher than that of rats in Sham group (p<0.05).The inhibitory effect of lncRNA GAS5 knockdown on the apoptosis of neurons in CI rats may be related to the activation of the Notch1 signaling pathway. Yes TTC staining results revealed that lncRNA GAS5 knockdown could remarkably reduce the CI area of rats in CI group (p<0.05). 31799679 Gas5 LncRNA Mus musculus Non-alcoholic Fatty Liver Disease high fat diet-fed mice and free fatty acid-stimulated cells Regulation(miR-26a-5p/PDE4B & cAMP/CREB pathway) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Oil Red O Staining//IF GAS5 was activated in vitro and in vivo fatty liver models. Knockdown of GAS5 reduced lipid droplet accumulation, DNL associated enzymes and preserved mitochondrial function, while GAS5 overexpression exacerbated hepatic lipid accumulation. Mechanistically, GAS5 sponged miR-26a-5p to increase PDE4B expression and subsequently modulated DNL and mitochondrial function via the cAMP/CREB pathway. Yes Knockdown of GAS5 reduced lipid droplet accumulation, DNL associated enzymes and preserved mitochondrial function, while GAS5 overexpression exacerbated hepatic lipid accumulation. 35957809 Gas5 LncRNA Rattus norvegicus Aortic Aneurysm, Abdominal SMCs Regulation(EZH2-mediated RIG-I signaling pathway) Western Blot//Co-IP//Tunel//Flow Cytometry//RIP Increased GAS5 and RIG-I but decreased EZH2 were found in aortic tissues of AAA mice. EZH2 overexpression inhibited AAA formation and suppressed SMC apoptosis. Functionally, EZH2 blocked the RIG-I signaling pathway and consequently inhibited SMC apoptosis. GAS5 regulated EZH2 transcription in a negative manner in SMCs. Knockdown of GAS5 attenuated SMC apoptosis, which was reversed by EZH2 inhibition or RIG-I overexpression. Yes Knockdown of GAS5 attenuated SMC apoptosis, which was reversed by EZH2 inhibition or RIG-I overexpression. 34781960 Gas5 LncRNA Rattus norvegicus Brain Injuries HIBD neonatal rats Interaction(microRNA-128-3p/Bax/Akt/GSK-3β axis) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA Downregulated miR-128-3p and upregulated GAS5 and Bax mRNA were found in HIBD neonatal rats.Downregulation of lncRNA GAS5 prevents mitochondrial apoptosis in neonatal HIBD rats by regulating the miR-128-3p/Bax/Akt/GSK-3β axis. Yes Inhibition of lncRNA GAS5 in HIBD neonatal rats suppressed mitochondrial apoptosis. miR-128-3p knockdown annulled the inhibitory effect of inhibiting lncRNA GAS5 on mitochondrial apoptosis. 34718247 Gas5 LncRNA Rattus norvegicus Cerebral Ischaemia/Reperfusion Injury model rats Interaction(miR-1192/STAT5A/AQP4 ) In Vivo Experiment//Western Blot//Transfection//Tunel//CCK8//FISH//Flow Cytometry//qRT-PCR//Luciferase Report Assay//ChIP GAS5 and STAT5A were strongly expressed in stroke patients, and inhibition of GAS5 or STAT5A in model rats improved neurological function, reduced infarction and neuronal apoptosis, and diminished cerebral water content and astrocyte activation. Mechanistically, GAS5 targeted miR-1192, which negatively regulated STAT5A. Silencing of GAS5 and overexpresion of AQP4 led to lower cell viability and higher apoptosis and inflammation than GAS5 silencing alone. Yes GAS5 and STAT5A were strongly expressed in stroke patients, and inhibition of GAS5 or STAT5A in model rats improved neurological function, reduced infarction and neuronal apoptosis, and diminished cerebral water content and astrocyte activation. Furthermore, GAS5 or STAT5A downregulation restored proliferation and restrained apoptosis and inflammation in OGD/R-induced astrocytes. 36195691 GAPLINC LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cells interaction[miR-378,MAPK1 ] CCK8//qRT-PCR//Luciferase Report Assay The lncRNA GAPLINC expression was upregulated and positively correlated with MAPK1 expression in gastric cancer tissues and cells.Taken together, lncRNA GAPLINC promotes gastric cancer cell proliferation by acting as a molecular sponge of miR-378 to modulate MAPK1 expression. Yes Additionally, lncRNA GAPLINC promoted the expression of MAPK1 and the enhancement of GC cell proliferation and cell cycle progression by LncRNA GAPLINC was dependent on MAPK1 in vitro and in vivo. 29785127 GAPLINC LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation[miR-661/eEF2K Signaling Pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//FISH//Luciferase Report Assay//Colony Formation Assay We found that GAPLINC expression was up-regulated in NSCLC tissues and cell lines.Our findings indicate that GAPLINC promotes NSCLC tumorigenesis by regulating miR-661/eEF2K cascade and provide new insights for the pathogenesis underlying NSCLC and potential targets for therapeutic strategy. Overexpression of GAPLINC was associated with poor prognosis in patients with NSCLC. Yes Silencing of GAPLINC significantly inhibited cell proliferation, promoted apoptosis, and induced cell cycle arrest in the G0/G1 phase. Results from xenograft transplantation showed that GAPLINC silencing inhibited the tumor growth in vivo. 30522114 GAPLINC LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma Surgical tissue samples of 40 patients undergoing ESCC radical surgery Expression [highly expressed] CCK8//qRT-PCR//Transwell Assay The expression of lncRNA GAPLINC in ESCC tissues was significantly higher than that in corresponding adjacent normal tissues (P<0.05) and correlated with the degree of tumor differentiation (P<0.05). Compared with human esophageal normal epithelial cell lines, the expression of LncRNA GAPLINC was significantly higher in the human ESCC cell line (P<0.05). Yes CCK-8 assays showed that LncRNA GAPLINC overexpression increased the growth rate of cells (P<0.05). Transwell experiments showed that LncRNA GAPLINC overexpression increased the ability of cell migration and invasion compared to control cells (P<0.05). Annexin V assay revealed that LncRNA GAPLINC silencing increased early stage apoptosis (P<0. 05). 34262290 GAPLINC LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Expression[highly expressed] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay The upregulated expression of GAPLINC was found both in HCC tissues and cells. The expression of GAPLINC was correlated with tumor stage, distant metastasis and pathological grade of HCC. Moreover, GAPLINC was confirmed as an independent risk factor for prognosis of patients with HCC. Yes In HCC-LM3 and MHCC-97H cells, cells transfected with GAPLINC siRNA inhibited cell migration, invasion, proliferation and EMT in HCC cells. 31415284 GAPLINC LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Expression[highly expressed] CCK8//qRT-PCR//Western Blot//Transwell Assay In our results, GAPLINC expression is elevated in osteosarcoma tissues and cell lines, and correlated with advanced Enneking stage, present distant metastasis, and poor histological grade. Survival analyses indicated that GAPLINC expression was negatively associated with overall survival, and GAPLINC high-expression was an independent risk factor in osteosarcoma patients. Yes The in vitro studies showed knockdown of GAPLINC depressed osteosarcoma cell migration and invasion via inhibiting CD44 expression, but no effect on cell proliferation. 30177521 GAPLINC LncRNA Homo sapiens Glioblastoma GBM tissues and cell lines Interaction[sponging miR-331-3p] Wound Healing Assay//Invasion Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay We found that GAPLINC expression was significantly up-regulated in both GBM tissues and cell lines. Our findings suggested that GAPLINC served as an oncogenic lncRNA in GBM through negative modulation of miR-331-3p, providing a novel treatment targeting for GBM. The overexpression of GAPLINC was associated with shorter overall survival and disease-free survival. Yes Functional assays indicated that GAPLINC silencing suppressed GBM cells proliferation, migration, and invasion, and promoted apoptosis. 30657584 GAPLINC LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[TGF-β1 ] qRT-PCR//Western Blot We showed that GAPLINC was up-regulated in NSCLC tissues and positively correlated with TGF-β1. TGF-β1 may mediate lncRNA GAPLINC expression to promote NSCLC cell invasion and migration. Follow-up study showed that high GAPLINC level in NSCLC tissue was closely correlated with poor survival rate of NSCLC patients. Yes Over-expressions of TGF-β1 and GAPLINC resulted to accelerated migration and invasion of NSCLC cells. 31447565 GAPLINC LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines Interaction(miR-135b-5p/CSF1 Axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//IHC//Transwell Assay GAPLINC was significantly upregulated in RCC tissues and cell lines and was associated with a poor prognosis in RCC patients. Mechanistically, we found that GAPLINC upregulates oncogene CSF1 expression by acting as a sponge of miR-135b-5p. Yes Knockdown of GAPLINC repressed RCC growth in vitro and in vivo, while overexpression of GAPLINC exhibited the opposite effect. 34722262 GALNT5 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues interaction[HSP90] qRT-PCR This lncRNA was transcribed independently of the coding region of GALNT5 and was determined to be markedly upregulated in human gastric carcinoma relative to their corresponding normal gastric tissues by quantitative RT-PCR (qRT-PCR) analysis of tissues from 122 gastric carcinoma patients. Our results also indicated that GALNT5 uaRNA might function in gastric cancer by binding with HSP90. The expression of GALNT5 uaRNA was significantly correlated with the TNM stage and with lymph node metastasis. Yes Further results demonstrated that GALNT5 uaRNA facilitated the proliferation and migration of gastric cancer cells in vitro and promoted tumor growth in a mouse model of human gastric cancer. 29743591 GAL LncRNA Homo sapiens Colorectal Neoplasms CRLM tissues and cells Interaction(GLUT1) qRT-PCR//RNA Pull-Down//Western Blot Here, we report an lncRNA, GAL (glucose transporter 1 (GLUT1) associated lncRNA), that was upregulated in CRLM tissues compared with primary colorectal cancer (CRC) tissues or matched normal tissues and was associated with the overall survival rates of CRLM patients. Mechanistically, GAL interacted with the GLUT1 protein to increase GLUT1 SUMOylation, inhibiting the effect of the ubiquitin-proteasome system on the GLUT1 protein. Here, we report an lncRNA, GAL (glucose transporter 1 (GLUT1) associated lncRNA), that was upregulated in CRLM tissues compared with primary colorectal cancer (CRC) tissues or matched normal tissues and was associated with the overall survival rates of CRLM patients. F Yes Functionally, GAL served as an oncogene because it promoted CRC cell migration and invasion in vitro and enhanced the ability of CRC cells to metastasize from the intestine to the liver in vivo. 35149838 GACAT3 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction( miR-497) Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay Here, we found that GACAT3 showed a higher expression in GC tissues and cell lines.Mechanistically, we proved that GACAT3 directly binds to microRNA-497 (miR-497), and GACAT3 expression was inversely correlated with miR-497 expression. Increased GACAT3 level was significantly associated with a shorter overall survival of patients with GC. Yes Functionally, we demonstrated that knockdown of GACAT3 significantly inhibited proliferation, colony formation, migration, and invasion of GC cells in vitro. Moreover, underexpression of GACAT3 decreased tumorigenesis in vivo. 29091858 Gas5 LncRNA Mus musculus Myocardial Infarction the hearts of MI-modeled rat regulation[PDCD4,miR-21] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay Decreased expressions of GAS5 and PDCD4 as well as increased miR-21 level were observed in the hearts of MI-modeled rat, accompanying with morphologically myocardial cell injury, as well as collagen deposition and fibrosis, and elevated levels of cTnl, CK, CK-MB and LDH. LncRNA-GAS5 regulates PDCD4 expression to mediate MI-induced cardiomyocyte apoptosis via targeting miR-21, suggesting that GAS5 could be a therapeutic target for MI. Yes In the cell model, the knockdown of GAS5 promoted cell survival, prevented cell cycle arrest and inhibited cell apoptosis while the overexpression of GAS5 showed the opposite effects. 32308118 Gas5 LncRNA Mus musculus Coronary Artery Disease CAD tissues Regulation[Wnt/β-catenin signaling pathway] qRT-PCR Overexpression of GAS5 in CAD rats determines improvement of hyperlipidemia, attenuation of myocardial injury, inhibition of cardiomyocyte apoptosis, oxidative stress, inflammatory injury, and abnormal activation of the Wnt/β-catenin signaling pathway in myocardial tissues. Yes Overexpression of GAS5 in CAD rats determines improvement of hyperlipidemia, attenuation of myocardial injury, inhibition of cardiomyocyte apoptosis, oxidative stress, inflammatory injury, and abnormal activation of the Wnt/β-catenin signaling pathway in myocardial tissues. 30511472 Gas5 LncRNA Mus musculus Atherosclerosis arteries Interaction[upregulation of miR-135a] qRT-PCR//Luciferase Report Assay//RIP//Western Blot Our data revealed that GAS5 was upregulated in AS mice model and ox-LDL-treated macrophages.In conclusion, our study suggested that GAS5 silencing repressed the malignant progression of AS at least partly through upregulation of miR-135a. Yes GAS5 silencing alleviated lipid metabolic disorders and inflammation in AS mice and ox-LDL-treated macrophages. 31545249 GAS5 LncRNA Homo sapiens ovarian clear cell carcinoma OCCC tissues and cell lines Interaction(miR-31-5p/ARID1A axis) RNA Pull-Down//Western Blot//Transfection//RIP//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay GAS5 and ARID1A levels were significantly decreased, while miR-31-5p levels were strongly elevated in the OCCC tissues and cell lines. LncRNA GAS5 inhibited cell viability and invasion of OCCC through activation of ARID1A by sponging miR-31-5p. Patients with lower GAS5/ARID1A levels had shorter overall survival times. Yes Overexpression of GAS5 or inhibition of miR-31-5p suppressed cell viability and invasion of OCCC cells and upregulated the protein levels of ARID1A. Moreover, overexpression of miR-31-5p reversed the effects of overexpression of GAS5. 34414664 GAS5 LncRNA Homo sapiens Leukemia, B-Cell Interaction[sponging miR-222] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results showed that the expression of lncRNA GAS5 was decreased in B lymphocytic leukaemia patients compared with the healthy group, and the levels of lncRNA GAS5 in B lymphocytic leukaemia cell lines were significantly higher than those in the normal B cell line, whereas the levels of miR-222 were increased in B lymphocytic leukaemia patients compared with the healthy group. Finally, the luciferase reporter assay showed a direct target interaction between lncRNA GAS5 and miR-222. The regression analysis showed a negative correlation between the levels of lncRNA GAS5 and miR-222. Thus, our data suggested that lncRNA GAS5 could effectively sponge miR-222 to modulate human B lymphocytic leukaemia cell tumourigenesis and metastasis. Yes Moreover, cell culture experiments indicated that lncRNA GAS5 overexpression decreased B lymphocytic leukaemia cell proliferation, promoted B lymphocytic leukaemia cell apoptosis, arrested B lymphocytic leukaemia cells in the G1 phase of the cell cycle, and inhibited B lymphocytic leukaemia cell invasion. 31594210 GAS5 LncRNA Homo sapiens Polycystic Ovary Syndrome blood regulation[IL-6] qRT-PCR//ELISA//Cell Apoptosis Assay GAS5 was upregulated in plasma of PCOS patients. GAS5 is upregulated in PCOS and regulates cell apoptosis and the expression of IL-6. Yes Cell apoptosis analysis showed that overexpression of GAS5 significantly decreased apoptosis rate of KGN cells. Silencing of GAS5 increased the rate of KGN cell apoptosis. 33308258 GAS5 LncRNA Homo sapiens Uveal melanoma UM cells and clinical specimens regulation[GAS5/miR-21 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our experiments demonstrated that GAS5 was markedly downregulated in UM cells and clinical specimens. Taken together, our findings suggest that GAS5/miR-21 axis is implicated in the pathogenesis of UM and might serve as a potential therapeutic target. Yes Overexpression of GAS5 inhibited, whereas knockdown of GAS5 promoted the viability, migration, and invasion of UM cells. 33273862 GAS5 LncRNA Homo sapiens Arthritis, Rheumatoid RA synovial tissues and RAFLSs Interaction(miR-128-3p/HDAC4 axis) RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//IHC//Invasion Assay GAS5 and HDAC4 were downregulated, and miR-128-3p was upregulated in RA synovial tissues and RAFLSs. GAS5 acted as a miR-128-3p sponge to upregulate HDAC4 expression. Besides, GAS5/miR-128-3p/HDAC4 axis regulated RA progression partially through the AKT/mTOR pathway. Yes Function analysis indicated that GAS5 curbed proliferation, migration, invasion, inflammation, and facilitated apoptosis of RAFLSs. Rescue assay confirmed that miR-128-3p overexpression or HDAC4 knockdown weakened the inhibitory effect of GAS5 or anti-miR-128-3p on RA development. 33611674 GAS5 LncRNA Homo sapiens Arthritis, Rheumatoid serum samples of RA patients and in RA-FLSs Interaction( miR-222-3p/Sirt1 signalling axis) Western Blot//Transfection//qPCR//CCK8//Flow Cytometry//RIP//Luciferase Report Assay//BrdU//ELISA GAS5 expression was found to be downregulated in the serum samples of RA patients and in RA-FLSs. Mechanistically, GAS5 indirectly regulates Sirt1 expression by binding miR-222-3p. Further experiments confirmed that Sirt1 overexpression restored the anti-RA activity of GAS5 under miR-222-3p mimic. Yes GAS5 overexpression or the inhibition of miR-222-3p impeded the activity of RA-FLSs by repressing their proliferation and inflammation and by promoting apoptosis. 33215529 GAS5 LncRNA Homo sapiens Arthritis, Rheumatoid synovial tissue Interaction(miR-361-5p/PDK4 ) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining By qRT-PCR, GAS5 and PDK4 were found to be overexpressed in synovial tissue, fibroblast-like synoviocytes of RA patients and LPS-induced chondrocytes, while the miR-361-5p expression was significantly reduced. PDK4 targeted by miR-361-5p could inhibit RA, and partially eliminated the effect of miR-361-5p on RA. Our study suggested that GAS5 suppressed RA by competitively adsorbing miR-361-5p to modulate PDK4 expression. Yes GAS5 overexpression resulted in a decrease in the proliferation and Bcl-2 protein expression, and an increase in the Bax protein level. On the contrary, miR-361-5p sponged by GAS5 could accelerate chondrocyte proliferation, inhibit apoptosis. 34715498 GAS5 LncRNA Homo sapiens Pulmonary Disease, Chronic Obstructive MRC-5 cell line Interaction(miR‑223‑3p/NLRP3 axis) Western Blot//qPCR//CCK8//RIP//Luciferase Report Assay//ELISA//Bioinformatics Analysis//IF Additionally, LPS induced the increase in GAS5 mRNA expression levels and the release of inflammatory factors (IL‑2, IL‑6, IL‑10 and TNF‑α), suggesting that GAS5 is implicated in pyroptosis in COPD. A dual‑luciferase assay demonstrated that GAS5 could directly bind to microRNA‑223‑3p (miR‑223‑3p), and NLRP3 is a direct target of miR‑223‑3p. Furthermore, GAS5 reduced the expression levels of miR‑223‑3p, while it increased the expression levels of NLRP3. Yes Furthermore, upregulation of GAS5 promoted cell death and inhibited proliferation in the MRC‑5 cell line. Additionally, increased GAS5 expression significantly promoted the production of caspase‑1, IL‑1β, IL‑18, cleaved GSDMD and NLR pyrin domain containing protein 3 (NLRP3). 35583006 GAS5 LncRNA Homo sapiens Diabetic Foot skin tissues Interaction(TAF15/HIF1A/VEGF pathway) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Tube Formation Assay//CCK8//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining//ChIP GAS5 and HIF1A were downregulated in the skin tissues of DFU patients, and GAS5 overexpression promoted cell proliferation, wound healing and tubule formation in HG-treated HUVECs.In addition, GAS5 facilitated HIF1A expression by interacting with TAF15. Rescue assays demonstrated that the suppression of HIF1A/VEGF pathway activation partially reversed the functional roles of GAS5 in HUVECs. Furthermore, GAS5 accelerated wound healing by activating the HIF1A/VEGF pathway in mice with DFUs. GAS5 activates the HIF1A/VEGF pathway by binding to TAF15, resulting in accelerated wound healing in DFUs. Yes GAS5 and HIF1A were downregulated in the skin tissues of DFU patients, and GAS5 overexpression promoted cell proliferation, wound healing and tubule formation in HG-treated HUVECs. 33875793 GAS5 LncRNA Homo sapiens Glioma glioma tissues and cells Interaction( SPACA6-miR-125a/let-7e Axis) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We showed that lncRNA-GAS5 expression decreased in high-grade glioma tissues and cells, which might be associated with poor prognosis. We further discovered that GAS5 inhibited the viability of glioma cells through miR-let-7e and miR-125a by protecting SPACA6 from degradation. Moreover, GAS5 played an anti-oncogenic role in GBM through the combined involvement of let-7e and miR-125a in vivo and in vitro. We showed that lncRNA-GAS5 expression decreased in high-grade glioma tissues and cells, which might be associated with poor prognosis. Yes GAS5 overexpression lowered cell viability, suppressed GBM cell migration and invasion, and impaired the stemness and proliferation of glioma stem cells (GSCs). 36106122 GAS5 LncRNA Homo sapiens Neuroendocrine Tumors PitNET tissues and cells Interaction(miR-27a-5p/cylindromatosis axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay These results suggest that lncRNA GAS5 acts as an endogenous sponge by binding miR-27a-5p to increase the expression of its target gene CYLD, thereby inhibits PitNETs cell proliferation and tumor growth. Yes In vivo lncRNA GAS5 overexpression inhibited GH3 cell tumor growth, while miR-27a-5p mimic or silenced CYLD attenuated the effect of lncRNA GAS5 on GH3 cell tumor growth. 35435104 GAS5 LncRNA Homo sapiens Osteosarcoma hFOB 1.19 and U2OS osteosarcoma cells Interaction(miR-21) qRT-PCR//Transfection//Invasion Assay//Migration Assay In this study, we report the status of growth arrest specific 5 (GAS5) in lung metastatic osteosarcomas. GAS5 was generally downregulated in osteosarcoma patients (n = 24) compared to healthy controls (n = 10) and even more so in patients with lung metastatic disease(n = 11) compared to the patients without metastasis (n = 13). We also report a role of miR-21 in GAS5-mediated effects. Downregulation of GAS5 in hFOB 1.19 and U2OS osteosarcoma cells enhanced their migration and invasion, along with an upregulated epithelial-mesenchymal transition (EMT), as evidenced by downregulated E-cadherin and upregulated vimentin, ZEB1, and ZEB2. Downregulation of GAS5 also resulted in a significantly increased expression of miR-21. Moreover, downregulation of such elevated miR-21 was found to reverse the effects of GAS5 silencing. miR-21 was also found to be elevated in osteosarcoma patients with its levels particularly high in patients with lung metastasis. Our observations reveal a possible role of GAS5 and miR-21 in lung metastasis of osteosarcoma, presenting them as novel targets for therapy. Yes Moreover, downregulation of such elevated miR-21 was found to reverse the effects of GAS5 silencing. 34386496 GAS5 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL cell lines Interaction(miR‑18a‑5p/RUNX1 axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Bioinformatics Analysis//ChIP The expression levels of GAS5 and RUNX1 were downregulated; however, miR‑18a‑5p expression was upregulated in the DLBCL cell lines compared with the normal controls.GAS5 directly interacted with miR‑18a‑5p by acting as a competing endogenous RNA (ceRNA) and reversed the low expression of RUNX1 induced by miR‑18a‑5p. Moreover, RUNX1 enhanced BAX expression by directly binding to the BAX promoter. Yes Additionally, the knockdown of RUNX1 reversed the inhibitory effects of GAS5 on the proliferation and cell cycle G1 arrest, and its promoting effects on the apoptosis of OCI‑Ly3 and TMD8 cells. 34698360 GAS5 LncRNA Homo sapiens Adenocarcinoma, Follicular FTC tissues and cells Interaction(miR-221-3p/CDKN2B axis ) In Vivo Experiment//Western Blot//Transfection//FISH//qRT-PCR//RIP//Luciferase Report Assay//IHC Our results displayed that GAS5 was downregulated, while miR-221-3p was upregulated in FTC tissues and cells. GAS5 acted as a sponge of miR-221-3p, and CDKN2B was a target gene of miR-221-3p. Additionally, GAS5 inhibited cell cycle and proliferation of FTC cells via reducing miR-221-3p expression to enhance CDKN2B expression. Yes What's more, overexpression of GAS5 or miR-221-3p inhibition induced G0/G1 phase arrest and inhibited cell proliferation of FTC cells. 34130294 GAS5 LncRNA Homo sapiens HIV CD4 T cells Interaction(miR-21) Flow Cytometry//qRT-PCR//Western Blot We found that GAS5 negatively regulates miR-21 expression, which in turn controls critical signaling pathways involved in DNA damage and cellular response. These results indicate that targeting the GAS5-miR-21 axis may improve activity and longevity of CD4 T cells in ART-treated PLHIV. Yes We found that GAS5 negatively regulates miR-21 expression, which in turn controls critical signaling pathways involved in DNA damage and cellular response. 33776993 GAS5 LncRNA Homo sapiens Asthma Interaction(miR-217/HDAC4 axis) qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Western Blot TGF-β1, GAS5, HDAC4 were up-regulated, while miR-217 was down-regulated in bronchial mucosal tissues of asthmatic children and TGF-β1-treated BEAS-2B cells. Mechanically, GAS5 acted as a sponge for miR-217 to regulate the expression of HDAC4. Yes Furthermore, overexpression of HDAC4 rescued the effects of GAS5 knockdown on viability and apoptosis of TGF-β1-induced BEAS-2B cells. GAS5 knockdown induced cell viability and hampered cell apoptosis in TGF-β1-stimulated BEAS-2B cells by regulating the miR-217/HDAC4 axis. 33864612 GAS5 LncRNA Homo sapiens Mycoplasma pneumoniae pneumonia Serum Expression(highly expressed) qRT-PCR//Transfection//ELISA lncRNA GAS5 is highly expressed in the serum of children with MPP and inhibits LAMPs-induced apoptosis and alveolar macrophage inflammation. Yes lncRNA GAS5 is highly expressed in the serum of children with MPP and inhibits LAMPs-induced apoptosis and alveolar macrophage inflammation. 36034211 GAS5 LncRNA Homo sapiens Coronary Artery Disease AS Interaction(MicroRNA-194-3p/TXNIP Axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//H&E Staining//IHC aised GAS5 and TXNIP and degraded miR-194-3p expression levels exhibited in AS. GAS5 bound to miR-194-3p while miR-194-3p targeted TXNIP. Yes Depleting GAS5 or restoring miR-194-3p enhanced proliferation and depressed apoptosis of ECs in AS. 33638792 GAS5 LncRNA Homo sapiens Sepsis-Associated Renal Injury sepsis-induced renal injury models Interaction(miR-579-3p/SIRT1/PGC-1α/Nrf2 signaling pathway) Western Blot//Transfection//Tunel//Flow Cytometry//RIP//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA GAS5 and SIRT1 were downregulated, whereas miR-579-3p was upregulated in in vitro and in vivo sepsis-induced renal injury models.GAS5 negatively and directly regulated miR-579-3p to reduce cell pyroptosis via the activation of SIRT1/PGC-1a/Nrf2 pathway. In addition, miR-579-3p suppressed PGC-1a/Nrf2 pathway to induce cell pyroptosis by directly targeting SIRT1. Yes GAS5 negatively and directly regulated miR-579-3p to reduce cell pyroptosis via the activation of SIRT1/PGC-1a/Nrf2 pathway. In addition, miR-579-3p suppressed PGC-1a/Nrf2 pathway to induce cell pyroptosis by directly targeting SIRT1. What's more, overexpression of GAS5, or knockdown of miR-579-3p, enhanced SIRT1 expression that led to the improved survival rate, reduced the weight loss, and relieved renal injuries in septic mice. 34010066 GAS5-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Interaction[increasing GAS5 stability ] qRT-PCR The GAS5-AS1 expression in CC tissues was markedly decreased when compared with that in the adjacent normal tissues.Mechanistically, it was found that GAS5-AS1 interacted with the tumor suppressor GAS5, and increased its stability by interacting with RNA demethylase ALKBH5 and decreasing GAS5 N6-methyladenosine (m6A) modification. Moreover, it was shown that m6A-mediated GAS5 RNA degradation relied on the m6A reader protein YTHDF2-dependent pathway. The downregulation of GAS5-AS1 was significantly correlated with the advanced FIGO stage, distant metastasis, lymphatic metastasis and poor prognosis in patients with CC. Yes Functionally, GAS5-AS1 drastically reduced CC cell proliferation, migration and invasion in vitro, and remarkably suppressed CC tumorigenicity and metastasis in vivo. 31497208 GMDS-DT LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Regulation[ miR-96-5p/CYLD signaling] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay In this study, we found that the expression of lncRNA GMDS-AS1 was significantly reduced in lung adenocarcinoma (LUAD) tissues and cells.Further studies revealed that GMDS-AS1 is a target gene of miR-96-5p, and GMDS-AS1 regulates proliferation and apoptosis of LUAD cells in association with miR-96-5p. In addition, we also confirmed that CYLD lysine 63 deubiquitinase (CYLD) is also a target gene of miR-96-5p. Through various validations, we confirmed that GMDS-AS1 can act as a ceRNA to upregulate the expression of CYLD by sponging miR-96-5p. Moreover, the intervention of GMDS-AS1/miR-96-5p/CYLD network can regulate the proliferation and apoptosis of LUAD cells. In this study, we revealed that the GMDS-AS1/miR-96-5p/CYLD network based on ceRNA mechanism plays an important role in the development of LUAD and provides a new direction and theoretical basis for targeted therapy of LUAD. Yes Upregulated GMDS-AS1 can significantly inhibit the proliferation of LUAD cells and promote cell apoptosis in vitro and in vivo. 31860169 GIHCG LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Interaction[repressing miR-200b] qRT-PCR Our results revealed that GIHCG is up-regulated in cervical cancer tissues and cell lines compared with adjacent normal tissues and normal cervical epithelial cell line, respectively. In summary, this study demonstrated that GIHCG functions as an oncogene in cervical cancer via repressing miR-200b. Yes Functionally, we found that overexpression of GIHCG promotes cell proliferation, inhibits cell apoptosis, and promotes cell migration of cervical cancer cells. 30719165 GIHCG LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and cell lines Regulation[ miR-429] qRT-PCR In our study, we showed that that the expression level of GIHCG was upregulated in TSCC tissues and cell lines.Our results suggested that GIHCG/miR-429 might play a vital role in TSCC progression. In addition, we indicated that high GIHCG expression was positively associated with poor overall survival. Yes Moreover, ectopic expression of GIHCG enhanced TSCC cell cycle, proliferation, and migration. Elevated expression of GIHCG inhibited the miR-429 expression in TSCC cells. 29953645 GIAT4RA LncRNA Homo sapiens Lung Neoplasms lung cancer tissues,cell lines Interaction[ binding to 227-589 AA of LSH] RNA Pull-Down//Western Blot//ISH//Co-IP//Migration Assay//CCK8//qRT-PCR//RIP//IHC//Invasion Assay Here, we showed that GIAT4RA, a poorly characterized lncRNA LOC102723729, was significantly decreased in lung cancer cells and tissues.Mechanistically, GIAT4RA was essential for the degradation of chromatin modifier lymphoid-specific helicase (LSH) by counteracting the deubiquintination in proteasome pathway by binding to 227-589 AA of LSH. GIAT4RA interfered with ubiquitin hydrolase Uchl3-mediated interaction and stabilization of LSH. LSH knockdown rescued GIAT4RA-promoted features, and LSH overexpression prevented GIAT4RA-induced phenotypes. Here, we showed that GIAT4RA, a poorly characterized lncRNA LOC102723729, was significantly decreased in lung cancer cells and tissues; while no association was observed with clinical risk factors, expression was linked with clinical stage and lymphatic metastasis. Higher expression of GIAT4RA was linked with overall survival in NSCLC. Yes GIAT4RA inhibited many characteristics of tumorigenesis including cell growth, clonal formation, migration and invasion, epithelial-mesenchymal transition, tumor sphere and tumor growth in vivo. 31417184 GHSROS LncRNA Homo sapiens Breast Neoplasms breast tissue Expression[highly expressed] qRT-PCR Reverse transcription‑quantitative polymerase chain reaction revealed that GHSROS expression was significantly upregulated in breast tumour tissues compared with normal breast tissue. Yes Induced overexpression of GHSROS in the MDA‑MB‑231 breast cancer cell line significantly increased cell migration in vitro, without affecting cell proliferation, a finding similar to our previous study on lung cancer cell lines. 31638176 GHSROS LncRNA Homo sapiens Prostatic Neoplasms tissues and cell lines( PC3, DU145, and LNCaP cells) Expression [highly expressed] In Vivo Experiment//Migration Assay//qRT-PCR//RNA-seq//Cell Proliferation Assay//IHC//Transwell Assay Yes Increased cellular proliferation of GHSROS-overexpressing PC3, DU145, and LNCaP prostate cancer cell lines in vitro was recapitulated in a subcutaneous xenograft model 33585078 GHRLOS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell lines and tissues Interaction(miR-346/APC Axis) Western Blot//CCK8//qRT-PCR//RIP//Colony Formation Assay//ChIP We found lncRNA GHRLOS was decreased in NSCLC cell lines and tissues which correlated with poor prognosis of NSCLC patients. Our data demonstrated that overexpression of lncRNA GHRLOS suppressed cancer cell proliferation and invasion as well as promoted cell apoptosis by regulating the expression of CDK2, PCNA, E-cadherin, N-cadherin, Bax, and Bcl-2 in NSCLC cells. Moreover, lncRNA GHRLOS was upregulated by the binding of TP53 to the GHRLOS promoter. The binding target of lncRNA GHRLOS was identified to be miR-346. We found lncRNA GHRLOS was decreased in NSCLC cell lines and tissues which correlated with poor prognosis of NSCLC patients Yes Our data demonstrated that overexpression of lncRNA GHRLOS suppressed cancer cell proliferation and invasion as well as promoted cell apoptosis by regulating the expression of CDK2, PCNA, E-cadherin, N-cadherin, Bax, and Bcl-2 in NSCLC cells. Moreover, lncRNA GHRLOS was upregulated by the binding of TP53 to the GHRLOS promoter. The binding target of lncRNA GHRLOS was identified to be miR-346. 33968785 GHET1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay GHET1 was up-regulated in breast cancer tissues and cell lines, and the up-regulation of GHET1 was positively correlated with larger tumor size, advanced clinical stage, lymph node metastasis and shorter overall survival. GHET1 was up-regulated in breast cancer tissues and cell lines, and the up-regulation of GHET1 was positively correlated with larger tumor size, advanced clinical stage, lymph node metastasis and shorter overall survival. Yes Knockdown of GHET1 suppressed cell proliferation, invasion and migration, and induced apoptosis and G0/G1 cell cycle arrest in MCF-cells. 29843220 GHET1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[PI3K/AKT/Cyclin D1/MMP2/9] Western Blot//ISH//Wound Healing Assay//qRT-PCR//MTT//IHC//Transwell Assay RT-PCR showed that lncRNA GHET1 and c-Myc expression in cancer tissue were significantly Expression[Expression[up-expression]-expression]regulated compared with those in adjacent samples (both P < 0.05, Figure 2A and ​and2B).2B). The results indicate that lncRNA GHET1 inhibition directly sExpression[Expression[up-expression]-expression]presses EGFR expression, significantly inhibiting the Expression[down-expression]stream PI3K/AKT/Cyclin D1/MMP2/9 pathway. Yes In vitro, lncRNA GHET1 knockExpression[down-expression] sExpression[Expression[up-expression]-expression]pressed cell proliferation, migration, and invasion and enhanced cell apoptosis by maintaining MCF-7 cells in the G1 phase of the cell cycle. Furthermore, lncRNA GHET1 knockExpression[down-expression] reduced the expression of EGFR and related proteins. 30787968 GHET1 LncRNA Homo sapiens Breast Neoplasms TNBC patients' tissues and the TNBC cell lines Interaction(miR-377-3p/GRSF1 Signaling Axis) Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay lncRNA GHET1 was significantly upregulated in the TNBC patients' tissues and the TNBC cell lines. Additionally, overexpression of lncRNA GHET1 upregulated both MMP-9 and MMP-2 protein expression levels. Correlation analysis found that miR-377-3p had a positive relationship with GRSF1, but had a negative relationship with lncRNA GHET1. miR-377-3p mimic attenuated the effects of lncRNA GHET1 on cellular proliferation, apoptosis, and migration of the TNBC cells. Yes Overexpression of lncRNA GHET1 significantly increased the proliferation and migration ability, but decreased apoptosis in the TNBC cells. 35509860 GHET1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues,cell lines Expression[highly expressed] qRT-PCR//Microarray In the present study, the expression of GHET1 in RCC tissues and the 786-O, A498 and 293 cell lines was assessed by reverse transcription-quantitative polymerase chain reaction. High expression levels of GHET1 were associated with distant metastasis and clinical stage severity, thus, high GHET1 expression may serve as a predictor for a poor prognosis. Yes Furthermore, silencing GHET1 suppressed cell growth, weakened cell migration and inhibited EMT of RCC cells in vitro. 30867747 GHET1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cell lines Interaction[HIF1α ] qRT-PCR//MTT//Colony Formation Assay//Western Blot In the present study, we found that the long non-coding RNA gastric carcinoma high expressed transcript 1 (GHET1) was overexpressed in ovarian cancer tissues and cell lines. Mechanistically, the candidate binding partners of GHET1 were explored by pull-down and mass spectrum. Of note, GHET1 was found to interact with the E3 ubiquitin ligase von Hippel-Lindau (VHL), which consequently blocked VHL-mediated degradation of hypoxia-inducible factor-1α (HIF1α) and enhanced the protein level of HIF1α in ovarian cancer cells. The up-regulated HIF1α promoted the glucose uptake and lactate generation of ovarian cancer cells. Collectively, our results suggested the oncogenic function of GHET1 via up-regulating the glycolysis in ovarian cancer and can be considered as a promising anti-cancer target. Up-regulation of GHET1 was positively correlated with the tumor size and metastasis of the ovarian cancer patients. Yes Overexpression of GEHT1 significantly promoted the proliferation and colony formation of ovarian cancer cells. 30988076 GHET1 LncRNA Homo sapiens Leukemia, Myeloid, Acute cell lines regulation[GHET1/miR-105/RAP2B axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot GHET1 expression was elevated in AML cell lines compared with normal bone marrow mononuclear cells.This study demonstrated that the GHET1/miR-105/Rap2B axis may be a critical signaling pathway involved in AML progression. Yes GHET1 knockdown led to inhibition of proliferation and promoted the differentiation and apoptosis of AML cell lines. 33123297 GHET1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues,cell lines Expression[highly expressed] qRT-PCR In our study, we found GHET1 expression was markedly elevated in cervical cancer tissue specimens and cell lines compared with adjacent normal cervical tissue specimens and human normal cervical cell line, respectively. Then, we found high expression of GHET1 is a useful biomarker to discriminate cervical cancer tissues from non-tumorous tissues, and associated with advanced clinical stage, lymph node metastasis, distant metastasis and poor histological grade in cervical cancer patients. Yes Knockdown of GHET1 expression markedly inhibits cervical cancer cell proliferation, migration, and invasion. The loss-of-function study indicated knockdown of GHET1 expression markedly inhibits cervical cancer cell proliferation, migration, and invasion. 30948501 GHET1 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines regulation[AKT/mTOR and Wnt/β-catenin signaling pathways] Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay//IF We proposed to examine the biological role of GHET1 in CC and the underlying mechanism and validated the up-regulated expression of GHET1 in CC cell lines. In conclusion, we revealed that down-regulation of GHET1 suppresses cervical cancer progression through regulating AKT/mTOR and Wnt/β-catenin signaling pathways, indicating GHET1 as a promising molecular biomarker for CC treatment improvement. Yes Loss-of-function assays demonstrated that down-regulation of GHET1 inhibited cell growth, migration and epithelial-to-mesenchymal transition (EMT) in CC. 31682716 GHET1 LncRNA Homo sapiens Thyroid Neoplasms  TC tissues Expression [highly expressed] Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Transwell Assay Our results showed that LncRNA GHET1 was significantly more upregulated in TC tissues than in adjacent normal tissues. LncRNA GHET1 was also increased in thyroid cancer cell lines compared to normal thyroid cell lines. The upregulation of LncRNA GHET1 was significantly associated with tumor invasion, gender, and lymph node metastasis in patients with thyroid cancer. The in vitro studies showed that silencing LncRNA GHET1 in BCPAP cells inhibited cell proliferation, cell invasion, and migration. Silencing of LncRNA GHETI also promoted the cell apoptotic rate, caused an increase in the cell population at the G0/G1 phase, and decreased the cell population at the S phase.  A recent study indicated that an increased LncRNA GHET1 expression level is associated with poor OS, tumor progression, and TNM stage in patients with multiple tumors and may serve as a useful prognostic biomarker in Chinese cancer patients Yes The in vitro studies showed that silencing LncRNA GHET1 in BCPAP cells inhibited cell proliferation, cell invasion, and migration. Silencing of LncRNA GHETI also promoted the cell apoptotic rate, caused an increase in the cell population at the G0/G1 phase, and decreased the cell population at the S phase.  35116711 GHET1 LncRNA Homo sapiens Prostatic Neoplasms PC tissues Regulation[HIF-1α/Notch-1 signaling pathway ] CCK8//qRT-PCR//Colony Formation Assay//Flow Cytometry We found that GHET1 showed higher expression in PC tissues and had a negative correlation with KLF2 expression. Additionally, si-GHET1 transfection induced KLF2 upregulation and HIF-1α/Notch-1 signal pathway suppression, which could be rescued by si-KLF2 transfection. These results suggest the key role of GHET1 in PC progression. Moreover, GHET1 might be explored to be a potential target for clinical treatment of PC. Yes Knockdown of GHET1 significantly suppressed the cell proliferation, induced cell cycle arrest at G0/G1 phase and promoted cell apoptosis. 30609158 GHET1 LncRNA Homo sapiens Head and Neck Neoplasms HNC tissues Expression[highly expressed] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The expression level of GHET1 was significantly increased in HNC tissues, compared with paired adjacent normal tissues. High GHET1 expression was significantly associated with advanced Tumor-Node-Metastasis stages and poor prognosis. Yes Furthermore, inhibition of GHET1 suppressed cell proliferation, induced cell apoptosis and caused cell cycle arrest in vitro. In addition, GHET1 silencing inhibited cell migration and invasion. 29725422 GHET1 LncRNA Homo sapiens Uterine Cervical Neoplasms cancer tissues regulation[PTEN/PI3 K/AKT signalling pathway] Western Blot//Wound Healing Assay//Tunel//Flow Cytometry//qRT-PCR//MTT//IHC//Transwell Assay The expression levels of lncRNA GHET1 and PTEN protein differed significantly between cancer and adjacent normal tissues (P< 0.05) and were negatively correlated in the clinical data. GHET1 knockdown suppressed cervical carcinoma development via the PTEN/PI3 K/AKT signalling pathway. Yes In vitro, proliferation rateswere significantly down-regulated in SiHa and HeLa cells. The GHET1 knockdown (si-GHET1) groups showed significantly higher G1 phase and apoptosis rates and significantly suppressed invasion and migration abilities compared with the normal control (NC) group (P< 0.05 for all). 32176622 GFRA1 CircRNA Homo sapiens Prostatic Neoplasms PCa tumor tissues Interaction(miR-3064-5p/HECTD1 axis) RNA Pull-Down//Western Blot//qPCR//RIP//PCR//IP//ELISA//Bioinformatics Analysis//IF In this study, circRNA microarrays using four pairs of PCa tissues were utilized to show that circGFRA1 was upregulated in PCa tumor tissues, our results showed that LMX1B could bind to the GFRA1 promoter and regulate circGFRA1 expression in PCa cells and circGFRA1 upregulated HECTD1 expression through sponging miR-3064-5p. Yes CircGFRA1 is suggested to play an oncogene role in PCa progression as the silencing of circGFRA1 inhibited the proliferation, migration, and immune escape activity of PCa cells. 35832649 GDNFOS1 LncRNA Homo sapiens Glioblastoma Regulated[up-regulated] CCK8//qRT-PCR//Western Blot//Transwell Assay Overall, GDNF expression, cell viability and invasion ability of glioblastoma cells significantly increased with GDNFOS1 overexpression and decreased with GDNFOS1 interference. Yes The invasive ability was significantly decreased in the GDNFOS1 interference group when compared with the negative control group. 31316623 GIHCG LncRNA Homo sapiens Cholangiocarcinoma cholangiocarcinoma tissue Expression(highly expressed) qRT-PCR//FISH The expression of lncRNA GIHCG in cholangiocarcinoma tissue is significantly increased, closely related to tumor size and lymph node metastasis. The results of the comprehensive analysis of survival, ROC, and correlation analysis with clinical data showed that lncRNA GIHCG has a significant correlation with lymph node metastasis in patients with cholangiocarcinoma. Yes Transwell results showed that lncRNA GIHCG could promote the migration of cholangiocarcinoma cells. 35196779 GIHCG LncRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues and cancer cell lines regulation[miR-29b-3p/ANO1 Axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay GIHCG was significantly upregulated in esophageal cancer tissues and relevant cancer cell lines.Our study revealed that lncRNA GIHCG promoted the progression of esophageal cancer by targeting the miR-29b-3p/ANO1 axis, suggesting that GIHCG might be a novel therapeutic target for esophageal cancer. Yes Downregulation of GIHCG significantly inhibited the growth, colony formation, invasion, migration and induced apoptosis of esophageal cancer cells in vitro. 33408485 GAS6 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cell lines Regulation(AMP-activated protein kinase/mTOR signaling pathway) In Vivo Experiment//IHC//Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay GAS6-AS1 was found to be upregulated in ccRCC tissues and cell lines, and patients with high GAS6-AS1 expression levels exhibited a poor prognosis. Small interfering (si)RNA GAS6-AS1 inhibited the activity, colony formation, invasiveness and glycolysis of OSRC-2 and SW839 cells, while GAS6-AS1 overexpression promoted these functions. Moreover, si-GAS6-AS1 increased the phosphorylation level of AMP-activated protein kinase (AMPK) and decreased that of mTOR, as well as decreasing proliferating cell nuclear antigen (PCNA), MMP-2 and hexokinase-2 (HK2) expression, which were reversed by inhibiting AMPK or mTOR. In addition, the silencing of GAS6-AS1 suppressed the growth of xenografted tumors and attenuated the expression of PCNA, MMP-2 and HK2 in tumor tissues. These findings conclude that GAS6-AS1 regulated the proliferation, invasiveness and glycolysis of ccRCC cells by regulating the AMPK/mTOR signaling pathway, and suggest that GAS6-AS1 may be a potential therapeutic target for ccRCC. GAS6-AS1 was found to be upregulated in ccRCC tissues and cell lines, and patients with high GAS6-AS1 expression levels exhibited a poor prognosis. Yes Small interfering (si)RNA GAS6-AS1 inhibited the activity, colony formation, invasiveness and glycolysis of OSRC-2 and SW839 cells, while GAS6-AS1 overexpression promoted these functions. 34429767 GIHCG LncRNA Homo sapiens Ovarian Neoplasms OC tissues Regulation[microRNA-429] CCK8//qRT-PCR//Colony Formation Assay GIHCG was highly expressed, whereas microRNA-429 was lowly expressed in OC tissues than that of paracancerous tissues.GIHCG is highly expressed in OC, which promotes OC development by stimulating cell cycle progression and cell proliferation by regulating microRNA-429. OC patients with higher expression of GIHCG showed shorter OS than those with lower expression. Yes GIHCG overexpression in HEY cells promoted cell cycle and colony formation abilities, which were reversed by microRNA-429 overexpression. 30556850 Gm9795 LncRNA Rattus norvegicus non-alcoholic steatohepatitis liver tissues Interaction(NF-kB/JNK pathway ) In Vivo Experiment//qRT-PCR//Western Blot//Microarray A total of 381 lncRNAs were found to be not only highly expressed in NAFLD, but also is going to go even higher in NASH. A novel LncRNA-gm9795 was significantly highly expressed in liver tissues of NASH animal models and NASH cell models. By staining with Nile red, we found that gm9795 did not affect the fat accumulation of NASH. However, gm9795 in NASH cell models significantly promoted the expression of TNF [Formula: see text], IL-6, IL-1[Formula: see text], the important inflammatory mediators in NASH. At the same time, we found that gm9795 upregulated the key molecules in endoplasmic reticulum stress (ERS), while NF-[Formula: see text]B/JNK pathways were also activated. When ERS activator Thapsigargin (TG) was introduced in cells with Ggm9757 si-RNA, NF-[Formula: see text]B and JNK pathways were activated. Yes The role and mechanism of LncRNA-gm9795 in NASH were explored by knocking down or over-expressing its expression. 33750416 Gm47283 LncRNA Homo sapiens Myocardial Infarction cardiomyocyte Interaction(miR-706/ Ptgs2/ferroptosis axis) In Vivo Experiment//qRT-PCR//Western Blot First, we identified 10 dysregualted lncRNAs and found that lncRNA Gm47283 was the top risk factor in MI. Bioinformatics analysis predicted that lncRNA Gm47283 exerted function via targeting miR-706 and Ptgs2. Ptgs2 was also the known regulator of ferroptosis. Yes Inhibition or overexpression of lncRNA Gm47283 could regulate Ptgs2 expression and downstream ferroptosis activity. Overexpression of miR-706 could inhibit the expression of Ptgs2 and the activity of ferroptosis, thereby attenuated cellular injury. 35485136 Gm44593 LncRNA Homo sapiens Hearing Loss HEI-OC1 cells Interaction(miR-29b/WNK1) Transfection//Tunel//RIP//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay The expression of lncRNA Gm44593 was significantly upregulated upon H2O2 and starvation treatment. We also proved that miR-29b is the direct target of lncRNA Gm44593. Overexpression of miR-29b completely restored the effect induced by lncRNA Gm44593. In addition, we provided evidences that WNK1 is the direct target of miR-29b. Yes Overexpression of lncRNA Gm44593 manifestly reduced the cell death rates. The ATP content, mtDNA content and mitochondrial membrane potential were alleviated upon overexpression of lncRNA Gm44593. 34967279 GM18840 LncRNA Homo sapiens Myocardial Infarction cardiac muscle tissues and myocardial cells Interaction(cis-regulatory regions of genes involved in developmental processes, such as Junb, Rras2, and Bcl3) In Vivo Experiment//RNA Pull-Down//qRT-PCR//RIP//RNA-seq//Luciferase Report Assay//Bioinformatics Analysis Gm18840 was upregulated after myocardial infarction in both in vivo and in vitro MIRI models. Gm18840 was 1,471 nt in length and localized in both the cytoplasm and the nucleus of HL-1 cells. Functional studies showed that the knockdown of Gm18840 promoted the apoptosis of HL-1 cells. Gm18840 directly interacts with histones, including H2B, highlighting a potential function in transcriptional regulation. Further ChIRP-seq and RNA-seq analyses showed that Gm18840 is directly bound to the cis-regulatory regions of genes involved in developmental processes, such as Junb, Rras2, and Bcl3. Yes Functional studies showed that the knockdown of Gm18840 promoted the apoptosis of HL-1 cells. 34322480 Gm16638-201 LncRNA Mus musculus Nervous System Diseases hippocampus (HIP) of CUMS Regulation(14-3-3Ɛ Pathway) Bioinformatics Analysis In conclusion, we found that overexpression of Gm16638-201 negatively regulated several target genes and inhibited the 14-3-3Ɛ pathway in the PFC of CUMS induced depressive mice. This promising result suggests that Gm16638-201 may be a potential novel therapeutic target for depression. Yes We further confirmed the down-regulation of 14-3-3Ɛ and the nine predicted target genes in the PFC of CUMS mice except for Sgip1 and IL-16. In addition, they were also down-regulated in the primary cortical cell cultures with overexpression of Gm16638-201 constructed using an adenoviral-medicated gene expression system. 36328497 Gm15290 LncRNA Homo sapiens Lung Neoplasms tumor tissues,cell lines Regulation[miR-615-5p] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Transwell Assay First, we found that lncRNA Gm15290 was markedly up-regulated in tumor tissues from NSCLC patients and NSCLC cell lines, compared with adjacent normal tissues and normal lung cell line HBE respectively.The results of RNA pull-down assays confirmed that Gm15290 directly bound with miR-615-5p Gm15290 negatively regulated the expression of miR-615-5p and increased the protein levels of miR-615-5p target genes, including IGF2, AKT2, and SHMT2 Yes Our results showed that overexpression of Gm15290 significantly increased the proliferation and invasion of A549 cells and suppressed cell apoptosis. Knockdown of Gm15290 suppressed A549 cell proliferation and invasion and promoted cell apoptosis. 30287504 Gm14320 LncRNA Mus musculus Melanoma mouse melanoma B16 cells Interaction(miR-344d-3-5p/Prc1 (and Nuf2) axis) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay In this study, integrative analysis of whole transcriptome sequencing data demonstrated that lncRNA-Gm31932 is significantly decreased in all-trans retinoic acid (ATRA)-induced and sodium 4-phenylbutanoate (PB-4)-induced mouse melanoma B16 cells. Furthermore, a series of experiments (luciferase reporter assay, RNA pull-down assay, and western blotting) showed that lncRNA-Gm3932 down-regulated Prc1 and Nuf2 by competitively sponging miR-344d-3-5p, which subsequently reduced the expression of cell cycle-related proteins CDK2, CDC2, and Cyclin B1, and increased the expression of P21 and P27. Yes Silencing lncRNA-Gm31932 could inhibit B16 cell proliferation, with cell cycle arrest at the G0/G1 phase and obvious differentiation characteristics, e.g., increased cell volume, melanin content and tyrosinase (Tyr) activity. 35393397 Gm12610 LncRNA Mus musculus acute myocardial infarction heart tissues Interaction[ IL-33/ST2 pathway] RNA Pull-Down//Western Blot//Co-IP//Tunel//RIP//qRT-PCR Compared with sham group, lncRNA ANRIL and ST2 expression levels were up-regulated, and the apoptosis of myocardial cells was increased in heart tissues of AMI group. LncRNA ANRIL regulated myocardial cell apoptosis through IL-33/ST2 pathway. Yes In vivo experiments found that interfering lncRNA ANRIL relieved myocardial cell apoptosis and improved heart function in AMI mice. 31674275 Gm12610 LncRNA Mus musculus Diabetic Nephropathies renal cortical tissues from ANRIL knockout (KO) mice and wild type (WT) mice Regulation In Vivo Experiment//RNA-seq These findings suggest that as ANRIL regulates a large number of molecules of pathogenetic significance, it may potentially be a drug target for DN and other chronic diabetic complications. Yes ANRIL knockout (KO) prevented a large number of such alterations. The altered transcripts include metabolic pathways, apoptosis, extracellular matrix protein synthesis and degradation, NFKB related pathways, AGE-RAGE interaction pathways etc. ANRIL KO prevented majority of these pathways. 35984863 Gm12610 LncRNA Mus musculus Cerebral Infarction brain tissue Regulation[NF-κB signaling pathway] qRT-PCR//Tunel//Western Blot Polymerase Chain Reaction (PCR) results revealed that the expression level of lncRNA ANRIL in the CI group was significantly increased when compared with that of the sham group (p<0.05).At the same time, knockdown of lncRNA ANRIL markedly decreased the level of Bax, whereas increased the expression of Bcl-2 (p<0.05). Besides, the number of apoptotic cells in the CI + lncRNA ANRIL siRNA group was remarkably decreased (p<0.05). In addition, lncRNA ANRIL down-regulation remarkably inhibited the phosphorylation of p65 (p<0.05). Yes The results of mNSS and TTC staining manifested that knockdown of lncRNA ANRIL could significantly reduce CI-induced neurological deficits and CI area (p<0.05). 31799680 Gm12610 LncRNA Mus musculus Uremic Cardiomyopathy UC mice Interaction(miR-181b-5p/S1PR1 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//IF ANRIL/S1PR1 were up-regulated and miR-181b-5p was down-regulated in UC mice. ANRIL silencing up-regulated miR-181b-5p and down-regulated S1PR1 (a target of miR-181b-5p). Yes ANRIL silencing increased the body weight, recovered renal function [decreased blood urea nitrogen (BUN) and serum creatinine (Scr)] and cardiac function [decreased left ventricular end-diastolic diameter (LVEDD), LV end-systolic diameter (LVESD), LV systolic anterior wall thickness (LVAWS), LV end-diastolic anterior wall thickness (LVAWD), myocardial performance index (MPI), and isovolumic relaxation time (IVRT); increased LV ejection fraction (LVEF), LVEF/MPI, fractional shortening (FS), and E- and A-waves (E/A)], inhibited the inflammation [decreased interferon (IFN)-γ, interleukin (IL)-2, IL-10, and tumor necrosis factor (TNF)-α], and relieved pathological injuries and fibrosis. ANRIL silencing also recovered the viability and inhibited the inflammation of activated T cells in vitro, and inhibited T cell activation in UC mice in vivo. In addition, miR-181b-5p overexpression exhibited same effects with ANRIL silencing in UC. ANRIL silencing inhibited T cell activation through regulating miR-181b-5p/S1PR1, contributing to the remission of UC. 36302829 Gm12610 LncRNA Mus musculus Ischemic Stroke MCAO/R mice Interaction(miR-671-5p/NF-κB Pathway) Western Blot//Transfection//FISH//qRT-PCR//Luciferase Report Assay//RNA-seq//H&E Staining//Cell Proliferation Assay//ELISA The results showed that ANRIL levels increased in IS model, downregulation of ANRIL reduced infract area, neurological deficit scores and injured cells, and prolong fall latency time in MCAO/R mice, improved cell viability and reduced cell cytotoxicity in OGD/R cells. This work clarified that downregulation of ANRIL reduced neuroinflammation by negatively regulating miR-671-5p to inhibit NF-κB in IS models, which provided a theoretical foundation for the protective effect of downregulating ANRIL for IS patients. Yes The results showed that ANRIL levels increased in IS model, downregulation of ANRIL reduced infract area, neurological deficit scores and injured cells, and prolong fall latency time in MCAO/R mice, improved cell viability and reduced cell cytotoxicity in OGD/R cells. 35359242 GLS-AS LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues Interaction[Myc/GLS pathway] RNA Pull-Down//Northern Blot//Co-IP//FISH//RIP//Luciferase Report Assay//ChIP GLS-AS was downregulated in pancreatic cancer tissues compared with noncancerous peritumor tissues. Collectively, our study implicates a novel lncRNA-mediated Myc/GLS pathway, which may serve as a metabolic target for pancreatic cancer therapy, and advances our understanding of the coupling role of lncRNA in nutrition stress and tumorigenesis. Yes Ectopic overexpression of GLS-AS inhibited proliferation and invasion of pancreatic cancer cells by repressing the Myc/GLS pathway. 30563888 GLIS2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissue and cell lines regulation[NF-κB pathway] Western Blot//ISH//qPCR//FISH//PCR//Microarray//IF We revealed that circGLIS2 expression was higher in CRC tissue and cell lines. Overall, our study reveals that circGLIS2, acting as a potential oncogene, maintains the abnormal activation state of the NF-κB signaling pathway via the miR-671 sponge mechanism in CRC cells. Yes Gain-and-loss function assays showed that circGLIS2 was involved in the regulation of cell migration. 32968054 GLIDR LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cells Interaction(miR-1270/TCF12 axis) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining On the basis of the outcomes of RT-qPCR experiments, the relative expression of GLIDR was evidently up-regulated in LUAD cells, while that of miR-1270 was down-regulated. Luciferase reporter, RNA pull down and RIP assays indicated that GLIDR could sponge miR-1270 in LUAD. Additionally, TCF12 was proved as the target gene of miR-1270. Yes The down-regulation of GLIDR inhibits cell proliferation in accordance with the results of CCK-8, EdU and colony formation assays, and accelerates cell apoptosis according to the results of flow cytometry and JC-1 analyses. 34369267 GK-IT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(DUSP6/ERK/MAPK pathway) Migration Assay//CCK8//qRT-PCR//FISH//Flow Cytometry//Invasion Assay In this study we identified an unreported lncRNA, termed GK-IT1 that was aberrantly overexpressed in ESCC tissues and cells. Mechanistically, GK-IT1 competitively bound to mitogen-activated protein kinase 1 (MAPK1) to prevent the interaction between dual specificity phosphatase 6 (DUSP6) and MAPK1, thereby controlling the phosphorylation of MAPK1 and promoting ESCC progression. GK-IT1 was closely associated with advanced clinical stage, and it was an independent prognostic indicator of ESCC. Yes Functional assays verified that GK-IT1 significantly promoted ESCC proliferation, invasion, and migration, and suppressed ESCC apoptosis and autophagy. Furthermore, tumorigenesis experiments in nude mice indicated that GK-IT1 promoted ESCC tumor growth and metastasis. 35608100 GIHCG LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[miR- 1281] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In GC, GIHCG was significantly overexpressed and significantly increased cell proliferation and migration, with the possible mechanism of upregulatingTLE1 expression through adsorption of miR-1281. Yes In GC, GIHCG was significantly overexpressed and significantly increased cell proliferation and migration, with the possible mechanism of upregulatingTLE1 expression through adsorption of miR-1281. 31050210 GIHCG LncRNA Homo sapiens Breast Neoplasms BCa tumor tissue Interaction[microRNA-1281] CCK8//qRT-PCR//EdU Staining RT-PCR results showed that the GIHCG level was remarkably higher in the BCa tumor tissue than in adjacent ones. QRT-PCR results indicated that silencing GIHCG increased the expression of miR-1281, thereby promoting the malignant progression of BCa. Also, the silence of miR-1281 reversed the effect of GIHCG on the proliferative capacity of BCa, thus increasing the cell anti-apoptotic ability. Compared with patients with low expression of GIHCG, patients with high expression of GIHCG had higher pathological grades and a lower overall survival. Yes Besides, the proliferation ability of BCa cells in GIHCG knockdown groExpression[up-expression] was significantly decreased compared with NC groExpression[up-expression]. 31858553 GIHCG LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues Expression(highly expressed) CCK8//Flow Cytometry//RIP//EdU Staining GIHCG is upregulated in RCC tissues compared with adjacent normal renal tissues. Serum GIHCG level is significantly reduced after radical resection of RCC. Increased expression of GIHCG is positively correlated with advanced TNM stages, Fuhrman grades, and poor prognosis. Serum GIHCG level is also significantly upregulated in RCC patients and correlated with advanced TNM stages. Yes Functional assays showed that knockdown of GIHCG significantly represses proliferation and migration of RCC cells. 29364470 GCC2-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissue Expression[highly expressed] CCK8//qRT-PCR//Transwell Assay//FISH GCC2-AS1 expression was significantly upregulated in lung adenocarcinoma tissues as compared with normal tissues. An elevated level of GCC2-AS1 was strongly correlated with shorter overall survival time and was identified as an independent prognostic marker for LUAD patients. Yes Depletion of GCC2-AS1 inhibited the proliferation and invasion of LUAD cells in vitro. 33575222 GAU1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer sample Interaction(GALNT8) qRT-PCR//Survival Analysis In the human cancer transcriptome library MiTranscriptome, we identified GAU1 as the top upregulated lncRNA in colorectal cancer (CRC) by sample set enrichment analysis (overexpression ranking percentile = 99.75%, P < 10-50), which is coexpressed with the potential oncogene GALNT8 (Spearman rho = 0.67, P = 2.44 × 10-23, TCGA dataset n = 184). Experimental data revealed that GAU1 regulates the expression of GALNT8. Yes overexpression of either GAU1 or GALNT8 significantly promotes the cell cycle and proliferation of CRC cell lines and correlates with poor prognosis in patients with CRC (P = 3.04 × 10-2), while silencing of GAU1 or GALNT8 suppressed the cancer cell proliferation and induced the CRC cell line resistance to oxaliplatin in vitro treatment. 34239555 GATD3 LncRNA Homo sapiens Breast Neoplasms tumor and adjacent non-tumor breast tissues Regulation[Oct4/Sox2/miR-302/miR-106b axis] qRT-PCR//Western Blot The ES1 expression level was detected as significantly higher in cancerous tissues compared to the adjacent non-cancerous samples.Altogether, for the first time, our findings reveal that ES1 controls the proliferation and death of breast cancer cells by regulating the Oct4/Sox2/miR-302/miR-106b axis. Yes Knockdown experiments show that ES1 suppression in breast cancer cells restricts cancer cell proliferation and cell cycle progression. Moreover, ES1 inhibition can also induce apoptosis and cellular senescence. 30927330 GASAL1 LncRNA Homo sapiens Heart Failure blood Interaction[TGF-β1] qRT-PCR//ELISA//Western Blot We found that plasma levels of TGF-β1 were significantly higher, while levels of GASL1 in plasma were significantly lower in chronic heart failure (CHF) patients compared to the control group. GASL1 expression was not significantly affected by TGF-β1 overexpression in cardiomyocytes, while cardiomyocytes with GASL1 overexpression showed downregulated TGF-β1. Overexpression of GASL1 led to a decreased, while TGF-β1 overexpression led to an increased apoptotic rate of cardiomyocytes under H2O2 treatment. In addition, TGF-β1 overexpression attenuated the effect of GASL1 overexpression. Low pretreatment plasma levels of GASL1 were closely associated with poor survival of CHF patients. Yes Overexpression of GASL1 led to a decreased, while TGF-β1 overexpression led to an increased apoptotic rate of cardiomyocytes under H2O2 treatment 31223316 GASAL1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cell lines regulation[Wnt3a/β-catenin signaling] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay LncRNA GASL1 was down-regulated in ESCC cell lines, and GASL1 inhibited ESCC cell progression and regulated cell cycle arrest in ESCC cells.In conclusion, lncRNA GASL1 regulates cell migration, invasion and cell cycle stagnation by inactivating the wnt/β-catenin signaling. Yes LncRNA GASL1 was down-regulated in ESCC cell lines, and GASL1 inhibited ESCC cell progression and regulated cell cycle arrest in ESCC cells. In vivo, GASL1 inhibited tumor growth. 33248356 GAS8-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction(miR-21-3p) CCK8//qRT-PCR//RNA Pull-Down//Transwell Assay Results of the present study demonstrated that the expression levels of GAS8-AS1 in gastric cancer tissues were significantly decreased, whereas its expression did not differ among cancer tissues at different clinical stages. In addition, the expression levels of miR-21-3p were markedly increased in cancer tissues, and miR-21-3p expression was negatively associated with the expression of GAS8-AS1. The direct interaction between GAS8-AS1 and miR-21-3p was predicted using the starBase database and was confirmed by using an RNA pull-down assay. Low expression levels of GAS8-AS1 predicted poor 5-year survival rates for 70 patients with gastric adenocarcinoma from the Affiliated Hospital of Xuzhou Medical University (Xuzhou, China) during patient follow-up. Yes In addition, the overexpression of GAS8-AS1 inhibited cancer cell proliferation, while the overexpression of miR-21-3p promoted cancer cell proliferation and attenuated the effects of GAS8-AS1. Overexpression of miR-21-3p promoted cancer cell migration and invasion, whereas overexpression of GAS8-AS1 did not affect cell migration or invasion. 34992681 GAS8-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary cell lines Regulation[ miR-135b-5p/CCND2 axis] qRT-PCR We found that GAS8-AS1 was down-regulated in PTC cell lines and inhibited proliferation and cycle of PTC cell.In addition, we also proved that overexpressed GAS8-AS1 inhibited tumor formation in vivo GAS8-AS1 suppresses PTC cell growth through the miR-135b-5p/CCND2 axis. Yes We found that GAS8-AS1 was down-regulated in PTC cell lines and inhibited proliferation and cycle of PTC cell. 30429236 GAS8-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines interaction[binding with Beclin1] Western Blot//Wound Healing Assay//qRT-PCR//RIP//MTT//Colony Formation Assay//EdU Staining//Transwell Assay LncRNA GAS8-AS1 was decreased in OC tissues and cell lines, and high expression of GAS8-AS1 indicated a higher 5-year survival rate of OC patients.Our study suggested GAS8-AS1 inhibited OC progression by activating autophagy via binding with Beclin1, and GAS8-AS1 might be a potential therapeutic target for OC clinical treatment. LncRNA GAS8-AS1 was decreased in OC tissues and cell lines, and high expression of GAS8-AS1 indicated a higher 5-year survival rate of OC patients. Yes Overexpression of GAS8-AS1 suppressed growth of OC cells, while deletion of GAS8-AS1 promoted the progression of OC cells. 33116622 GAS8-AS1 LncRNA Homo sapiens Glioblastoma GBM patients and the healthy controls Regulation(lncRNA NEAT1) Western Blot//Transfection//qRT-PCR//Cell Proliferation Assay//Invasion Assay//Transwell Assay GAS8-AS1 was downregulated, while lncRNA NEAT1 was upregulated in the plasma of GBM patients. Yes Overexpression of GAS8-AS1 reduced the expression levels of NEAT1 in GBM cells, while knock-down of GAS8-AS1 increased the expression levels of NEAT1. However, overexpression of NEAT1 showed no significant effects on the expression of GAS8-AS1. Knock-down of GAS8-AS1 promoted GBM cell proliferation and invasion and enhanced the activation of the Wnt/β-catenin pathway. However, the effects of knock-down of GAS8-AS1 were alleviated by the knock-down of NEAT1. 33942556 GAS8-AS1 LncRNA Homo sapiens Thyroid Neoplasms PTC tissues and cell lines regulation[miR-187-3p/ATG5 and miR-1343-3p/ATG7 Axes] CCK8//qRT-PCR//IHC//Luciferase Report Assay We found that GAS8-AS1 was downregulated in PTC tissues and cell lines. In conclusion, upregulation of ATF2 activated GAS8-AS1-promoted autophagy of PTC cells by sponging oncogenic miR-187-3p and miR-1343-3p and upregulating the expression of ATG5 and ATG7, respectively, making GAS8-AS1 a potential prognostic biomarker and therapeutic target for PTC. In patients with PTC, low GAS8-AS1 expression was associated with higher tumor-node-metastasis (TNM) stage and lymph node metastasis (LNM). Yes Functionally, GAS8-AS1 significantly promoted autophagy and inhibited PTC cell proliferation in vitro and promoted tumorigenesis in vivo. 33230459 GAS8-AS LncRNA Homo sapiens Colorectal Neoplasms blood Interaction[lncRNA AFAP1-AS1] CCK8//qRT-PCR In the present study we found that plasma GAS8-AS1 was upregulated in early stage CRC patients, and downregulation of GAS8-AS1 effectively distinguished CRC patients from healthy controls.GAS8-AS1 overexpression mediated the downregulation of AFAP1-AS1 in colon cancer cells, while AFAP1-AS1 overexpression did not significantly affect GAS8-AS1 expression. Expression level of GAS8-AS1 decreased, while expression level of AFAP1-AS1 increased with the increase of primary tumor diameters. Yes GAS8-AS1 overexpression led to inhibited, while AFAP1-AS1 overexpression led to promoted proliferation of CRC cells, and AFAP1-AS1 overexpression reduced the inhibitory effects of GAS8-AS1 overexpression on cancer cell proliferation. 31132513 GAS6-DT LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction[upregulation of FUT4] Migration Assay//CCK8//qRT-PCR//Invasion Assay//Transwell Assay GAS6-AS2 expression was high in BC tumors.With regard to its mechanism, GAS6-AS2 acted as a competing endogenous RNA that sponged microRNA-493 (miR-493), thereby increasing the expression of fucosyltransferase IV (FUT4). Either miR-493 inhibition or FUT4 upregulation abrogated the consequences of GAS6-AS2 knockdown in BC cells. These results revealed that GAS6-AS2 sponges miR-493 to enhance the malignant characteristics of BC in vitro and in vivo by increasing FUT4 expression. Thus, this lncRNA is an effective therapeutic target in BC and a promising diagnostic biomarker of this cancer. GAS6-AS2 expression was high in BC tumors, manifesting a strong correlation with tumor size, lymph node metastasis, TNM stage, and shorter overall survival in patients with BC. Yes A knockdown of GAS6-AS2 restricted BC cell proliferation, migration, and invasion in vitro and retarded tumor growth in vivo. 31839366 GAS6-DT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Regulation[PI3K/AKT/FoxO3a signaling pathway ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay GAS6-AS2 was up-regulated in HCC tissues and cells. In conclusion, GAS6-AS2 knockdown suppressed proliferation, migration, and invasion but promoted apoptosis of HCC cells by impeding PI3K/AKT/FoxO3a signaling pathway through regulating the GAS6-AS2/miR-493-5p/OTUB1 axis. Yes knockdown inhibited proliferation, migration, and invasion but promoted apoptosis. MiR-493-5p, a target of GAS6-AS2, was down-regulated in HCC tissues and cells. 31933797 GAS6-DT LncRNA Homo sapiens Urinary Bladder Neoplasms cell lines Regulation[GAS6-AS2/miR-298/CDK9 axis] Western Blot//Wound Healing Assay//RIP//qRT-PCR//MTT//Luciferase Report Assay//Cell Cycle Assay//Transwell Assay Moreover, expression of GAS6-AS2 was also increased in bladder cancer cells compared with normal bladder cells. In mechanism, GAS6-AS2 could function as a competitive endogenous RNA (ceRNA) via direct sponging miR-298, which further regulating the expression of CDK9. Yes Finally, we also proved that GAS6-AS2 knockdown suppressed tumour growth and metastasis in vivo. 30394665 GAS6-DT LncRNA Homo sapiens Osteosarcoma OS specimens and cell lines regulation[miR-934/BCAT1 axis] RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay We found that GAS6-AS2 was distinctly upregulated in both OS specimens and cell lines. Mechanistically, GAS6-AS2 positively regulated the expression of BCAT1 through sponging miR-934. Distinct up-regulation of GAS6-AS2 in OS was correlated with advanced clinical stages and shorter survivals. Yes Furthermore, GAS6-AS2 knockdown caused tumor suppressive effects via reducing cellular proliferation, migration and invasion, and promoting OS cell apoptosis. 32269179 GAS6-DT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Interaction(miR-144-3p/ MAPK6 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Colony Formation Assay//EdU Staining GAS6-AS2 was up-regulated, while miR-144-3p was suppressed in NSCLC cells compared with normal lung cells.GAS6-AS2 suppression could inhibit the progression of NSCLC cells, and miR-144-3p could attenuate the effect. GAS6-AS2 could function as a competitive endogenous RNA (ceRNA) via direct sponging miR-144-3p-3p, which further regulating the expression of MAPK6. Yes The knockdown of GAS6-AS2 could greatly suppress the tumor growth of NSCLC in vivo. 33459113 GAS6-DT LncRNA Homo sapiens Melanoma melanoma tissues and cells Interaction[GAS6/AXL/AKT/ERK signals] CCK8//ELISA//qPCR//Western Blot In this study, we found that lncRNA GAS6-AS2 is significantly elevated in melanoma tissues and cells. Collectively, our data identified GAS6-AS2 as an oncogenic lncRNA in melanoma via activation of GAS6/AXL/AKT/ERK signals. Elevated expression of GAS6-AS2 is positively correlated with advanced stages and poor prognosis in melanoma. Yes Functional assays demonstrated that ectopic expression of GAS6-AS2 promotes proliferation and inhibits apoptosis of melanoma cells. In contrast, knockdown of GAS6-AS2 inhibits proliferation and promotes apoptosis of melanoma cells. Furthermore, in vivo functional assays showed that GAS6-AS2 promotes melanoma xenograft growth. 31162889 GAS6-AS1 LncRNA Homo sapiens Breast Neoplasms BCa cell Interaction(miR-215-5p/SOX9 axis) CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis A decline in GAS6-AS1 level led to a significant decrease in BCa cell proliferation, and the ability for colony formation. Here, GAS6-AS1 competed as endogenous RNA by sequestering microRNA-215-5p (miR-215-5p) causing an enhanced expression of SRY-box transcription factor 9 (SOX9). Yes A decline in GAS6-AS1 level led to a significant decrease in BCa cell proliferation, and the ability for colony formation. Here, GAS6-AS1 competed as endogenous RNA by sequestering microRNA-215-5p (miR-215-5p) causing an enhanced expression of SRY-box transcription factor 9 (SOX9). 34976151 GAS6-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-370-3p/miR-1296-5p and FUS/TRIM14 ) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay GAS6-AS1 was greatly elevated in CRC and positively associated with unfavorable prognosis of CRC patients.Moreover, GAS6-AS1 exerted oncogenic function by competitively binding to miR-370-3p and miR-1296-5p, thereby upregulating TRIM14. Furthermore, we verified that GAS6-AS1 and TRIM14 both interact with FUS and that GAS6-AS1 stabilized TRIM14 mRNA by recruiting FUS. GAS6-AS1 was greatly elevated in CRC and positively associated with unfavorable prognosis of CRC patients. Yes Functionally, GAS6-AS1 positively regulates CRC proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro and induces CRC growth and metastasis in vivo. 35962353 GAS6-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML tissues Interaction(YBX1/MYC axis) qRT-PCR//RIP//ChIP We identified GAS6-AS1 was overexpressed in AML, and its aberrant function lead to more aggressive leukemia phenotypes and poorer survival outcomes. We revealed that GAS6-AS1 directly binds Y-box binding protein 1 (YBX1) to facilitate its interaction with MYC, leading to MYC transactivation and upregulation of IL1R1, RAB27B and other MYC target genes associated with leukemia progression. We identified GAS6-AS1 was overexpressed in AML, and its aberrant function lead to more aggressive leukemia phenotypes and poorer survival outcomes. Yes Further, lentiviral-based GAS6-AS1 silencing inhibited leukemia progression in vivo. 34753494 GAS6-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung tumor tissues Interaction(E2F1/GLUT1) In Vivo Experiment//Bioinformatics Analysis//Transfection//Migration Assay//qRT-PCR//Cell Proliferation Assay//Invasion Assay We discovered that overexpression of GAS6-AS1 suppressed tumor progression of LUAD both in vitro and in vivo. Mechanically, GAS6-AS1 was found to repress the expression of glucose transporter GLUT1, a key regulator of glucose metabolism. Further investigation identified that GAS6-AS1 directly interacted with transcription factor E2F1 and suppressed E2F1-mediated transcription of GLUT1, and GAS6-AS1 was downregulated in LUAD tissues and correlated with clinicopathological characteristics and survival of patients. GAS6-AS1 was downregulated in LUAD tissues and correlated with clinicopathological characteristics and survival of patients. Yes We discovered that overexpression of GAS6-AS1 suppressed tumor progression of LUAD both in vitro and in vivo. 34141461 GAS6-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD samples and cell lines Interaction(miR-24-3p/GTPase IMAP Family Member 6) In Vivo Experiment//Transfection//Wound Healing Assay//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The expression of GAS6-AS1 was notably downregulated in LUAD samples and cell lines and associated with a poor prognosis. Down-expressed GAS6-AS1 acted as a sponge for miR-24-3p and down-regulated the expression of its target, GTPase IMAP Family Member 6. The expression of GAS6-AS1 was notably downregulated in LUAD samples and cell lines and associated with a poor prognosis. Yes GAS6-AS1 overexpression inhibited the migration and invasion of A549 and H1650 cells. 34513660 GASAL1 LncRNA Homo sapiens stomach carcinoma regulation[PI3K/AKT and ras/raf/MEK/ERK pathways] CCK8//qRT-PCR//Luciferase Report Assay//BrdU//Transwell Assay GASL1 restrained GC cell proliferation and metastasis and blocked PI3K/AKT and ras/raf/MEK/ERK pathways by sponging miR-106a. Yes On cell metastasis, up-regulation of GASL1 decreased cell migration, invasion and related proteins matrix metalloproteinase (MMP)-9 and Vimentin levels. Meanwhile, silencing GASL1 exerted opposite effects on GC cells. 32897806 GASAL1 LncRNA Homo sapiens stomach carcinoma gastric cancer tissues Regulation[Wnt/β-catenin signaling pathway] CCK8//qRT-PCR//Western Blot The expression level of lncRNA GASL1 was significantly downregulated in gastric cancer tissues compared with adjacent normal tissues from patients with gastric carcinoma. GASL1 overexpression downregulated, while GASL1 knockdown Expression[up-expression]regulated β-catenin expression. Serum GASL1 levels distinguished patients with gastric carcinoma from healthy controls, and low expression levels of GASL1 were associated with decreased postoperative survival time. Yes GASL1 overexpression downregulated, while GASL1 knockdown Expression[up-expression]regulated β-catenin expression. GASL1 overexpression inhibited, and GASL1 knockdown promoted gastric cancer cell proliferation. 30988785 GASAL1 LncRNA Homo sapiens prostate carcinoma PC tissues Interaction[GLUT-1] CCK8//qRT-PCR The results demonstrated that GASL1 was significantly downregulated in the tissue and serum of patients with PC compared to those of healthy subjects.A GASL1 expression vector was transfected into PC cells prior to assessment of cell proliferation and expression of B cell lymphoma 2 (Bcl-2) and glucose transporter 1 (GLUT-1) by Cell Counting Kit-8 and western blotting, respectively. Overexpression of GASL1 Expression[up-expression]regulated Bcl-2 expression and downregulated GLUT-1 expression. In addition, GASL1 was used to distinguish patients with PC from healthy controls, and low expression levels of GASL1 were associated with short survival time. Expression levels of GASL1 were significantly associated with tumor size. Yes GASL1 overexpression inhibited PC cell growth. Overexpression of GASL1 Expression[up-expression]regulated Bcl-2 expression and downregulated GLUT-1 expression. 31186749 GATA6-AS LncRNA Homo sapiens cervical squamous cell carcinoma cervical squamous cell carcinoma tissues,blood Interaction[downregulating MTK-1] qRT-PCR//Western Blot//Transwell Assay It was identified that the expression levels of GATA6-AS were lower in tumor tissues compared with healthy tissues.In addition, serum levels of GATA6-AS were higher in patients compared with healthy controls. The expression levels of MTK-1 were also reduced following GATA6-AS overexpression. Therefore, the present study proposed that downregulated GATA6-AS expression was associated with tumor metastasis in cervical squamous cell carcinoma, and that GATA6-AS expression may inhibit cancer cell migration and invasion by downregulating MTK-1. The serum levels of GATA6-AS were associated with tumor metastasis, and may serve as a potential diagnostic and prognostic marker for cervical squamous cell carcinoma. Yes Furthermore, GATA6-AS overexpression inhibited cancer cell migration and invasion. 31404324 GATA6-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[miR-543/RKIP axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay GATA6-AS1 was significantly lowly expressed in NSCLC tissues and cell lines, and its low expression level was significantly correlated with larger tumor size and positive lymph node metastasis. GATA6-AS1 was significantly lowly expressed in NSCLC tissues and cell lines, and its low expression level was significantly correlated with larger tumor size and positive lymph node metastasis. Yes GATA6-AS1 overexpression inhibited the proliferation, migration, invasion and epithelial-mesenchymal transition of NSCLC cells, while GATA6-AS1 knockdown caused the opposite effects. 33061622 GATA6-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissue interaction[Sponges miR-324-5p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Expression of GATA6-AS1 was decreased in lung cancer based on the analysis of RNA sequencing dataset, TCGA data and RT-qPCR of clinical tissue samples.Oncogene miR-324-5p was predicted to interact with GATA6-AS1. Yes Via overexpression of GATA6-AS1, it was revealed that GATA6-AS1 inhibited lung cancer cell proliferation and invasion. 33061453 GATA6-AS LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[downregulating microRNA-25-3p] CCK8//qRT-PCR In the present study it was found that GATA6-AS was downregulated in tumor tissues compared with adjacent normal tissues. MicroRNA (miR)-25-3p was upregulated in tumor tissues compared with adjacent normal tissues and was inversely associated with GATA6-AS in tumor tissues only. The overexpression of miR-25-3p in gastric cancer cells resulted in no significant changes in the expression levels of GATA6-AS, whereas overexpression of GATA6-AS led to significantly downregulated miR-25-3p levels. Furthermore, overexpression of GATA6-AS inhibited cancer cell proliferation, with no effect on migration and invasion. The overexpression of miR-25-3p resulted in increased proliferation of cancer cells and attenuated the effects of GATA6-AS overexpression. Thus, it is postulated that GATA6-AS inhibits proliferation of gastric cancer cells by downregulating miR-25-3p. Yes Furthermore, overexpression of GATA6-AS inhibited cancer cell proliferation, with no effect on migration and invasion. 31611972 GATA6-AS LncRNA Homo sapiens Endometrial Neoplasms 17 pairs of EC tissues and adjacent ones Interaction(MMP) qRT-PCR//Luciferase Report Assay//Western Blot Our data showed that GATA6-AS expression in EC tissue specimens was remarkably lower than that in adjacent ones. Meanwhile, luciferase assay confirmed the binding relationship between GATA6-AS and MMP9. Yes In vitro cell experiments revealed that overexpression of GATA6-AS markedly attenuated the proliferation ability of EC cells while elevated their apoptosis. 34761584 GATA6-AS LncRNA Homo sapiens Uterine Cervical Neoplasms blood regulation[down-regulating miR-205] qRT-PCR We found that plasma GATA6-AS expression was down-regulated in CSCC patients than that in healthy females, and HPV infection did not significantly affect the plasma expression of GATA6-AS. Taken together, these results suggest that GATA6-AS may inhibit cell proliferation and promote cell apoptosis in CSCC by down-regulating miR-205. Yes In addition, GATA6-AS over-expression inhibited CSCC cell proliferation and promoted CSCC cell apoptosis, while miR-205 over-expression played opposite roles and attenuated the effects of GATA6-AS over-expression on CSCC cells. 33167959 GATA6-AS LncRNA Homo sapiens Glioma Glioma tissue Interaction[Downregulating lncRNA TUG1] CCK8//qRT-PCR GATA6-AS was significantly upregulated in glioma. TUG1 was significantly downregulated in glioma and was inversely correlated with GATA6-AS. GATA6-AS overexpression led to TUG1 downregulation, whereas TUG1 overexpression failed to significantly affect GATA6-AS. Yes GATA6-AS overexpression promoted glioma cell proliferation and inhibited apoptosis 31809214 GATA6-AS LncRNA Homo sapiens Gallbladder Neoplasms GBC tissues Interaction[downregulating miR-421] Invasion Assay//PCR//Transwell Assay We found that GATA6-AS was downregulated in tumor tissues than in adjacent healthy tissues of GBC patients, and GATA6-AS expression levels in tumor tissues decreased with the increase of clinical stages. MiR-421 overexpression failed to significantly affect GATA6-AS in GBC cells, while GATA6-AS overexpression resulted in inhibited miR-421 expression.MiR-421 overexpression led to increased migration and invasion rates of GBC. Rescue experiments (co-transfection) showed that miR-421 overexpression led to attenuated effects of GATA6-AS overexpression. We found that GATA6-AS was downregulated in tumor tissues than in adjacent healthy tissues of GBC patients, and GATA6-AS expression levels in tumor tissues decreased with the increase of clinical stages. Yes GATA6-AS overexpression led to decreased migration and invasion rates of GBC cells. 31632058 GATA6-AS LncRNA Homo sapiens Lymphoma, Mantle-Cell blood Interaction[downregulating GLUT1] CCK8//qRT-PCR//Western Blot It was found that plasma lncRNA GATA6-AS expression level was downregulated in patients with MCL, compared with that in healthy controls. Downregulation of lncRNA GATA6-AS has potential diagnostic value in early stage MCL. Yes Additionally, lncRNA GATA6-AS overexpression inhibited, whilst GLUT1 overexpression promoted the proliferation of JVM-2 and Z-138 MCL cells; GLUT1 overexpression partially reversed the inhibitory effects of lncRNA GATA6-AS overexpression. 31402946 GATA3‑AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines Interaction(miR‑30b‑5p‑Tex10 axis ) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay Upregulation of GATA3‑AS1 was revealed in PC tissues and cell lines. Collectively, these data indicated that the GATA3‑AS1‑miR‑30b‑5p‑Tex10 axis modulates tumorigenesis in PC, which may be associated with the Wnt/β‑catenin signaling pathway. Yes Knockdown of GATA3‑AS1 in PANC‑1 or AsPC‑1 cells markedly reduced cell viability, cell proliferation, and cell invasion abilities, while cell apoptosis was increased. In addition, GATA3‑AS1 knockdown suppressed the stemness of PANC‑1 and AsPC‑1 cells by decreasing the spheroid formation ability. A tumor xenograft in vivo assay demonstrated that GATA3‑AS1 knockdown inhibited tumorigenicity of AsPC‑1 cells. 33760161 GASAL1 LncRNA Homo sapiens Glioma tumor tissues, paired adjacent healthy tissues and serum Interaction[TGF-β1] CCK8//qRT-PCR//Western Blot The results demonstrated that a majority of patients with glioma (56/62, 90.3%) had significantly decreased expression of GASL1 in tumor tissues compared with expression in paired adjacent healthy tissues (P<0.05; Fig. 1), indicating that Expression[down-expression]regulation of GASL1 may be involved in the pathogenesis of glioma.In glioma cell lines with GASL1 overexpression, TGF-β1 expression was decreased and proliferation was inhibited. GASL1 knockExpression[down-expression] in glioma cell lines led to increased TGF-β1 expression and proliferation. TGF-β1 treatment had no effect on GASL1 expression, but TGF-β1 treatment partially rescued the inhibition of proliferation in cells overexpressing GASL1. Therefore, GASL1 may inhibit tumor growth of glioma by inactivating the TGF-β signaling pathway. All patients were followed Expression[Expression[up-expression]-expression] for 5 years or until their mortality to determine the survival rate. The Kaplan-Meier method was used to plot survival curves and the two groExpression[Expression[up-expression]-expression]s were compared using a log-rank test. As presented in Fig. 3, the overall survival rate of patients with a low serum level of GASL1 was significantly worse compared with that of patients with a high serum level of GASL1. Yes GASL1 overexpression inhibited glioma cell proliferation and Expression[down-expression]regulated TGF-β1 expression, but TGF-β1 treatment decreased the effect of GASL1 overexpression on proliferation. 31186801 GATA3-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[decreased PTEN, CDKN1A, and TP53] CCK8//qRT-PCR GATA3-AS1 was significantly upregulated in HCC tissues compared with matched normal tissues. Our data suggested that GATA3-AS1 promotes cell proliferation and metastasis of HCC by suppression of PTEN, CDKN1A, and TP53. The high expression of GATA3-AS1 was significantly correlated with larger tumor size, advanced TNM stage, and more lymph node metastasis. High GATA3-AS1 expression was markedly correlated with shorter overall survival times of HCC patients. Yes Furthermore, knockdown of GATA3-AS1 obviously inhibited Hep3B and HCCLM3 cell growth and migration, whereas overexpression of GATA3-AS1 had the opposite effects. 31871924 GATA3-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and EC cells Interaction(miR-361/ARRB2 axis) qRT-PCR//Western Blot GATA3-AS1 and ARRB2 were upregulated while miR-361 was downregulated in human EC tissues and EC cells. GATA3-AS1 negatively regulated miR-361 expression. ARRB2 was the direct target of miR-361 and could activate the Src/Akt pathway. In vivo, GATA3-AS1 knockdown suppressed tumor progression by upregulating the miR-361 expression. lncRNA GATA3-AS1 promoted EC invasion and migration by the miR-361/ARRB2 axis, which indicated that GATA3-AS1 might be a promising therapeutic option for advanced EC progression. Yes GATA3-AS1 knockdown constrained cell proliferation, invasion, migration, and EMT while promoting the apoptosis of EC cells by upregulating miR-361. 35788718 GATA3-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells regulation[stabilizing PD-L1 protein and degrading GATA3 protein] qRT-PCR GATA3-AS1 was markedly overexpressed in TNBC tissues and cells. GATA3-AS1 contributed to TNBC progression and immune evasion through stabilizing PD-L1 protein and degrading GATA3 protein, offering a new target for the treatment of TNBC. Yes Knockdown of GATA3-AS1 suppressed TNBC cell growth and enhanced the resistance of TNBC cells to immune response. 32687248 GATA3-AS1 LncRNA Homo sapiens Pre-Eclampsia placental samples with PE Interaction(miR-488-3p/ROCK1 Axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay Our results showed that GATA3-AS1 and ROCK1 were overexpressed while miR-488-3p was downregulated in placental samples with PE. Mechanically, GATA3-AS1 acted as a molecular sponge of miR-488-3p and miR-488-3p targeted ROCK1 in trophoblast cells. In rescue assays, ROCK1 overexpression or miR-488-3p downregulation reversed the effects of GATA3-AS1 silencing on trophoblast cell phenotypes. GATA3-AS1 is overexpressed in PE and promotes PE progression by the miR-488-3p/ROCK1 axis. Yes Functionally, GATA3-AS1 overexpression promoted trophoblast cell apoptosis and inhibited cell proliferation, migration, and invasion. 35993943 GATA2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Interaction(mir-940/PTPN12 axis) RNA Pull-Down//Western Blot//Colony Formation Assay//Flow Cytometry//RIP//Luciferase Report Assay//IHC//Bioinformatics Analysis//Transwell Assay The expression of GATA2-AS1 and PTPN12 was reduced, while miR-940 expression was enhanced in ESCC tissues and cell lines. Bioinformatics analysis, dual luciferase and RIP assays revealed that GATA2-AS1 upregulated PTPN12 expression by competitively targeting miR-940. miR-940 reversed the inhibitory effect of GATA2-AS1 on the biological behavior of ESCC cells. Yes In vivo experiments showed that GATA2-AS1 inhibited the progression of ESCC cells toward malignancy. 35364057 GATA2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(GATA2) Tunel//RIP//qRT-PCR//FISH//ChIP GATA2-AS1 and GATA2 were highly expressed in CRC cells.GATA2-AS1 expression was positively correlated with GATA2. GATA2-AS1 recruited DEAD-box helicase 3 X-linked (DDX3X) to stabilize GATA2 mRNA. GATA2 combined with GATA2-AS1 promoter to enhance GATA2-AS1 expression. Yes Knockdown of GATA2-AS1 and GATA2 impeded CRC cell proliferation, invasion, EMT and cancer stemness, and induced cell apoptosis. 35752837 GASAL1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miR-193b-5p/USP10 axis) qRT-PCR//Wound Healing Assay//FISH//Transwell Assay GASAL1 displayed a high expression in HCC cells and GASAL1 knockdown led to impeded cell proliferation and migration, as well as tumor progression. A series of mechanism analysis demonstrated GASAL1 could sponge miR-193b-5p to raise the expression of USP10. Moreover, USP10 could induce PCNA deubiquitination to promote HCC cell growth. Yes GASAL1 displayed a high expression in HCC cells and GASAL1 knockdown led to impeded cell proliferation and migration, as well as tumor progression. 34914965 LINC00265 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow and serum Regulation[PI3K-AKT pathway] qRT-PCR//Western Blot LINC00265 was significantly highly expressed in the bone marrow and serum of AML patients.Our findings not only demonstrated that LINC00265 contributes to AML proliferation, migration and invasion via modulation of PI3K/AKT signaling, but also suggested the potential value of LINC00265 as a clinical prognostic and a diagnostic marker for AML. Clinical assay indicated that AML patients with higher serum LINC00265 expression suffered poorer overall survival. Yes Functionally, overexpression of LINC00265 suppressed the capability of proliferation, migration and invasion in AML cell lines. 30536332 LINC00265 LncRNA Homo sapiens Colorectal Neoplasms Interaction[targeting EGFR] Western Blot//CCK8//qRT-PCR//Invasion Assay//Transwell Assay The expression level of LINC00265 is increased in CRC tissues.Our results indicate that LINC00265 induces cell proliferation, migration and inhibits CRC cells apoptosis by targeting EGFR. LINC00265 could be served as a diagnostic factor and therapeutic target for CRC patients. Yes In addition, further experiments indicated that LINC00265 knockdown impaired cell proliferation and invasion, promoted cell cycle distribution and apoptosis in HT29 cells. 31824175 LINC00273 LncRNA Homo sapiens Ovarian Neoplasms cells and tissues Expression(highly expressed) CCK8//qRT-PCR//Western Blot//Transwell Assay LINC00273 expression was significantly more increased in the cancerous ovarian tissues than the adjacent tissues. The LINC00273 expression of the ovarian cancer cell lines was higher than that of the normal ovarian epithelial cells. LINC00273 knockdown also promoted E-cadherin expression in the ovarian cancer cells, and inhibited vimentin, matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and N-cadherin, expression to inhibit the invasion and migration ability of the ovarian cancer cells. The in vivo experiments indicated that LINC00273 knockdown suppressed in vivo cancer cell proliferation in the ovaries. Yes LINC00273 knockdown greatly suppressed the proliferative and clonogenic function of these cancerous cells. The flow cytometry results revealed that LINC00273 knockdown notably induced G0/G1 phase arrest in the ovarian cancer cells. 36388777 hsa_circ_0084927 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells regulation[circ_0084927/miR-1179/CDK2 regulatory network] CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU Our results indicated that circ_0084927 was up-regulated in CC tissues and cells. Our results also provided novel candidate targets for CC treatment in that it revealed the circ_0084927/miR-1179/CDK2 regulatory network that strengthened CC aggressiveness. Yes Findings also revealed that circ_0084927 silence inhibited CC cell proliferation and adhesion while facilitating apoptosis and triggering cell cycle arrest. 32699532 circOSBPL10 CircRNA Homo sapiens Uterine Cervical Neoplasms CC cells regulation[miR-1179/UBE2Q1 axis] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay CircOSBPL10 characterized with cyclic structure was revealed to possess elevated expression in CC cells.FOXA1-induced circOSBPL10 facilitates CC progression through miR-1179/UBE2Q1 axis, highlighting a strong potential for circOSBPL10 to serve as a promising therapeutic target in CC. Yes CircOSBPL10 downregulation elicited suppressive impacts on CC cell proliferation and migration. 32831649 circNFATC3 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues, cell lines regulation[SDC2] qRT-PCR//Luciferase Report Assay//Western Blot We found that circNFATC3 expression was upregulated in primary CC tissues and positively correlated with CC tumor size and stromal invasion.Our data indicate that circNFATC3 sponges miR-9-5p to regulate SDC2 expression and, thereby, to promote CC tumor development. We found that circNFATC3 expression was upregulated in primary CC tissues and positively correlated with CC tumor size and stromal invasion. Yes In addition, we found that exogenous circNFATC3 overexpression enhanced the proliferation, migration and invasion of HeLa cells, while its knockdown reduced the malignancy of SiHa cells. 32902825 hsa_circ_0000285 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissue and cells regulation[miR197-3p-ELK1 Axis] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay circ_0000285 abundance was enhanced in CC tissue and cells and mainly located in cytoplasm. Knockdown of circ_0000285 repressed CC development by increasing miR197-3p and decreasing ELK1. Yes Silence of circ_0000285 suppressed cell viability and colony formation, arrested the cell cycle at the G0/G1 phase, and induced apoptosis and autophagy in CC cells. 32982457 LOC146880 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cell lines Interaction(miR-328-5p/FSCN1/MAPK axis) In Vivo Experiment//Western Blot//Transwell Assay//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//FISH//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//IF Moreover, CREB-binding protein (CBP) and H3K27 acetylation levels were significantly higher in the LOC146880 promoter in ESCC cell lines than in the controls. Bioinformatics analysis, dual luciferase reporter assays, and RNA immunoprecipitation assays showed that LOC146880 regulates FSCN1 expression in ESCC cells by sponging miR-328-5p. Moreover, FSCN1 expression correlated with activation of the MAPK signaling pathway in ESCC cells and tissues. Yes LOC146880 silencing inhibited in vitro proliferation, invasion, migration, and epithelial-mesenchymal transition of ESCC cells. LOC146880 silencing also induced G1-phase cell cycle arrest and apoptosis in ESCC cells. In vivo xenograft tumor volume and liver metastasis were significantly reduced in nude mice injected with LOC146880-silenced ESCC cells as compared to those injected with control shRNA-transfected ESCC cells. 34016787 hsa_circ_0003204 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines regulation[MAPK pathway] qRT-PCR//Western Blot We found that circRNA hsa_circ_0003204 was significantly upregulated in CC tissues. The MAPK pathway was different in hsa_circ_0003204 over-expression or down-expression cells, compared to parental cells. Yes The function and potential molecular mechanisms of hsa_circ_0003204 were also investigated in vitro and in vivo. Hsa_circ_0003204 knockdown reduced cell growth, migration, and invasion but promoted cells apoptosis. 33047994 hsa_circ_0084927 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells regulation[miR-142-3p/ARL2 axis] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay The expression of circ_0084927 and ARL2 was enhanced in cervical cancer tissues and cells, while the expression of miR-142-3p was opposite to them.Circ_0084927 accelerated the progression of cervical cancer partly by mediating the miR-142-3p/ARL2 axis. Yes Circ_0084927 knockdown significantly blocked cervical cancer cell proliferation, migration and invasion and induced cell cycle arrest. 33061617 hsa_circ_0084927 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells regulation[miR-634/TPD52 Axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay Hsa_circ_0084927 and TPD52 were upregulated while miR-634 was downregulated in CC tissues and cells. Hsa_circ_0084927 accelerated CC advancement via upregulating TPD52 via sponging miR-634, offering a new evidence to support hsa_circ_0084927 as a promising target for CC treatment. Yes Hsa_circ_0084927 silencing reduced tumor growth in vivo and induced cell cycle arrest, apoptosis, and curbed proliferation, colony formation, migration, and invasion of CC cells in vitro. 33061631 LOC107985656 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-106b-5p/LATS1 axis) qRT-PCR//MTT//RNA Pull-Down Results showed that LncRNA LOC107985656 was downregulated in HCC tissues and cells. LOC107985656 could activate the tumor-suppressive Hippo pathway by repressing yes association protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1, also known as TAZ) (two homologs of Yki) protein expression in HCC. Further investigation suggested that LOC107985656 regulated the expression of LATS1 by acting as a sponge for absorbing miR-106b-5p in HCC cells. Yes Upregulation of LOC107985656 inhibited the proliferation of HCC cells, whereas its knockdown promoted this phenomenon. 34565286 circPVT1 CircRNA Homo sapiens Uterine Cervical Neoplasms Expression[highly expressed] RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//FISH//Luciferase Report Assay In this research, bioinformatics analysis and RT-PCR analysis showed that hsa_circ_0009143 (circRNA_PVT1) was up-regulated in cervical cancer. Yes Knockdown of circRNA_PVT1 inhibits the migration and invasion of cervical cancer cells and would prevent pulmonary metastasis. Overexpression of circRNA_PVT1 induced migration and invasion of cervical cancer cells, which would result in the promotion of pulmonary metastasis. 33109773 hsa_circ_0007364 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues regulation[miR-101-5p/MAT2A axis] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay hsa_circ_0007364 was upregulated in CC,hsa_circ_0007364 promoted CC cell progression hsa_circ_0007364/miR-101-5p/MAT2A axis in CC. In the present study, we used bioinformatics analysis and a series of experimental analysis to characterize a novel circRNA, hsa_circ_0007364 was up-regulated and associated with advanced clinical features in CC patients. Yes Hsa_circ_0007364 inhibition notably suppressed the proliferation and invasion abilities of CC cells in vitro and reduced tumor growth in vivo. 33138667 hsa_circ_0102171 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells interaction[targeting miR-4465/CREBRF axis] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Interestingly, we discovered that circ_0102171 expressed at a high level in CC tissues and cells. Finally, in vivo data supported that silencing circ_0102171 hindered CC cell growth. In conclusion, circ_0102171 aggravates CC progression via targeting miR-4465/CREBRF axis. Yes Functionally, silencing circ_0102171 prohibited cell proliferation, migration and invasion, and strengthened cell apoptosis in CC in vitro. 33615474 circAGFG7 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Regulation[miR-370-3p/RAF1 signaling] qRT-PCR The levels of circAGFG1 was abundant in CC cells in comparison with normal cervical cell End1/E6E7. circAGFG1 promoted proliferation and migration of CC cells via enhancing the activity of RAF/MEK/ERK pathway by sponging miR-370-3p and further regulating RAF1. Yes The inhibitory effect of decreased circAGFG1 level on the proliferative and migratory abilities of CC cells was assessed. 31703640 hsa_circ_0075341 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Regulation[miR-149-5p/AURKA axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our data showed that the expression of hsa_circ_0075341 was significantly upregulated and associated with larger tumor size, advanced FIGO stage, and lymph-node metastasis in cervical cancer patients.Collectively, our data suggested that hsa_circ_0075341 promoted cervical cancer cell proliferation and invasion through regulating the miR-149-5p/AURKA axis, which provided a novel therapeutic target for cervical cancer treatment. Our data showed that the expression of hsa_circ_0075341 was significantly upregulated and associated with larger tumor size, advanced FIGO stage, and lymph-node metastasis in cervical cancer patients. Yes Hsa_circ_0075341 inhibition reduced cervical cancer cell proliferation and invasion in vitro. 31706100 hsa_circ_0005576 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Regulation[miR-153/KIF20A axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay In the present study, we analyzed two GSE microarrays to screen for CC-specific circRNAs and found two circRNAs both expressed in CC cells and tissues. Among them, circ_0005576 was significantly overexpressed in both CC tissues and cell lines.Mechanistically, circ 0005576 was mainly located in the cytoplasm and served as a sponge of miR-153-3p to increase kinesin family member 20A (KIF20A) expression. Rescue assays further validated the effects of circ_0005576/miR-153-3p/KIF20A axis on CC proliferation, migration and invasion. In conclusion, our research reveals a novel circ_0005576/miR-153-3p/KIF20A axis promoting CC progression, which may suggest a new insight into the pathogenesis of CC. Furthermore, upregulated circ_0005576 was positively associated with advanced FIGO stage, lymph node metastasis, but was negatively related with overall survival of CC patients. Yes Additionally, circ_0005576 knockdown induced a suppressed cell growth, colony formation and metastasis of HeLa and SiHa cells. 31545253 circCLK3 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Regulation[circCLK3/miR-320a/FoxM1 axis] Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We found that the level of circCLK3 was remarkably higher in cervical cancer tissues than in adjacent normal tissues, and closely associated with tumor differentiation, FIGO stage and depth of stromal invasion.The pull-down, luciferase reporter and RIP assays demonstrated that circCLK3 directly bound to and sponge miR-320a. MiR-320a suppressed the expression of FoxM1 through directly binding to 3'UTR of FoxM1 mRNA. In addition, FoxM1 promoted cell proliferation, migration, and invasion of cervical cancer, while miR-320a suppressed cell proliferation, migration, and invasion through suppressing FoxM1, and circCLK3 enhanced cell proliferation, migration and invasion through sponging miR-320a and promoting FoxM1 expression. In summary, circCLK3 may serve as a novel diagnostic biomarker for disease progression and a promising molecular target for early diagnoses and treatments of cervical cancer. We found that the level of circCLK3 was remarkably higher in cervical cancer tissues than in adjacent normal tissues, and closely associated with tumor differentiation, FIGO stage and depth of stromal invasion. Yes Down-regulated circCLK3 evidently inhibited cell growth and metastasis of cervical cancer in vitro and in vivo, while up-regulated circCLK3 significantly promoted cell growth and metastasis in vitro and in vivo. 31831728 circATP8A2 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues,cell lines Regulation[miR-433/EGFR axis] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Circ-ATP8A2 was significantly enhanced in CC specimens and cells. For the mechanism exploration, circ-ATP8A2 sponges miR-433 to release its suppression on epidermal growth factor receptor (EGFR) expression at post-transcriptional level. What's more, circ-ATP8A2 could promote cell progression by miR-433/EGFR axis in CC cells. Collectively, this work might offer a potential treatment target for CC. ABBREVIATIONS. Yes Knockdown of circ-ATP8A2 inhibited cell proliferation, migratory and invasive capacities and increased apoptotic cells. 31029604 circEIF4G2 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction[miR‑218/HOXA1 pathway] CCK8//qRT-PCR//Wound Healing Assay//Colony Formation Assay In the present study, circRNA isoform of eukaryotic translation initiation factor 4γ2 (circEIF4G2) was revealed to be significantly upregulated in CC tissues and cell lines. Additionally, circEIF4G2 was identified to serve as a sponge for microRNA‑218 (miR‑218), which targeted homeobox A1 (HOXA1). Furthermore, circEIF4G2 may increase the expression levels of HOXA1 by sponging miR‑218. Rescue experiments suggested that transfection with a miR‑218 inhibitor attenuated the inhibitory effects of circEIF4G2 knockdown on cell proliferation, migration and invasion. Furthermore, silencing HOXA1 reversed the effects of the miR‑218 inhibitor on CC cells. Collectively, the present findings suggested that circEIF4G2 promoted cell proliferation and migration via the miR‑218/HOXA1 pathway. Yes circEIF4G2 knockdown suppressed the malignant features of CC cells, including cell proliferation, colony formation, migration and invasion. 30896864 hsa_circ_0007534 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Regulation[miR-498/BMI-1 signaling] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The expression of hsa_circ_0007534 was upregulated in cervical cancer tissues and cell lines. MicroRNA-498 (miR-498) was identified as a target of the miRNA encoded by hsa_circ_0007534. Levels of miR-498 were decreased in cervical cancer tissues, a finding that was inversely correlated with hsa_circ_0007534 expression. miR-498 overexpression repressed the proliferation and invasion of cervical cancer cells. B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) was verified as a target gene of miR-498. BMI-1 overexpression reversed the effects of hsa_circ_0007534 depletion or miR-498 overexpression on cervical cancer cell proliferation and invasion. Yes Depletion of hsa_circ_0007534 decreased both the proliferation and invasion of cervical cancer cells. 31445025 circSLC26A4 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues,cell lines Regulation[miR-1287-5p/HOXA7 Axis] Western Blot//CCK8//qRT-PCR//FISH//RIP//RNA-seq//Luciferase Report Assay//Transwell Assay Here, a novel identified circRNA, circSLC26A4, was found to be upregulated in cervical cancer tissue and cells. Furthermore, circSLC26A4 acted as the sponge of miR-1287-5p; moreover, miR-1287-5p targeted the 3' UTR of HOXA7 mRNA. Mechanistically, RNA binding protein (RBP) quaking (QKI) was identified to interact with the QKI response elements (QREs) in SLC26A4 gene introns, thereby promoting circSLC26A4 biogenesis. Clinically, the high expression of circSLC26A4 was related to the poor survival of cervical cancer patients. Yes Functionally, cellular experiments indicated that circSLC26A4 knockdown repressed the proliferation, invasion, and tumor growth in vitro and in vivo. 31896069 circUBAP2 CircRNA Homo sapiens Uterine Cervical Neoplasms regulation[miR-361-3p/SOX4 axis] RNA Pull-Down//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay CircUBAP2 was up-regulated in CC tissues and cell lines and high circUBAP2 expression predicated poor outcome.CircUBAP2 represents a prognostic marker and contributes to tumor growth and metastasis via modulating miR-361-3p/SOX4 axis in CC, which indicates a potential therapeutic target for CC treatment. CircUBAP2 was up-regulated in CC tissues and cell lines and high circUBAP2 expression predicated poor outcome. Yes Knockdown of circUBAP2 suppressed cell proliferation, migration, invasion and EMT, while induced apoptosis in CC in vitro, and inhibited tumor growth and metastasis in vivo. 32760224 hsa_circ_0000069 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues ,cell lines regulation[miR-873-5p/TUSC3 axis] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We firstly demonstrated that hsa_circ_0000069 was significantly upregulated and closely related to the lymph node metastasis, and poor prognosis of CC patients.We demonstrated a critical hsa_circ_0000069-miR-873-5p-TUSC3 function network involved in the CC progression, which provides mechanistic insights into the roles of CircRNAs in CC progression and a promising therapeutic target for CC treatment. We firstly demonstrated that hsa_circ_0000069 was significantly upregulated and closely related to the lymph node metastasis, and poor prognosis of CC patients. Yes Besides, hsa_circ_0000069 promoted CC cell proliferation, migration, and invasion. The knockdown of hsa_circ_0000069 also inhibited CC tumor growth in vivo. 32655319 hsa_circ_0067934 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues,cell lines Regulation[miR-545/EIF3C axis ] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that circ_0067934 was overexpressed in CC tissues and cell lines.Mechanistically, silencing circ_0067934 increased miR-545 expression. MiR-545 repressed EIF3C expression through targeting its 3'-untranslated region. MiR-545 sExpression[Expression[up-expression]-expression]pressed the proliferation, migration, and invasion of CC cells, whereas restoration of EIF3C could rescue the effects of circ_0067934 knockExpression[down-expression]. Circ_0067934 Expression[Expression[up-expression]-expression]regulation was associated with advanced stage, lymph node metastasis, and poor prognosis in CC patients. Yes KnockExpression[down-expression] of circ_0067934 sExpression[Expression[up-expression]-expression]pressed the proliferation, colony formation, migration, invasion, and epithelial-mesenchymal transition of CC cells in vitro. Circ_0067934 loss also inhibited CC tumor growth in vivo. 30362562 hsa_circ_0000745 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells regulation[miR-409-3p/ATF1 Axis] Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0000745 and ATF1 were upregulated, whereas miR-409-3p was downregulated in CC tissues and cells. Circ_0000745 promoted the progression of CC through modulating miR-409-3p/ATF1 axis, indicating a promising biomarker for CC therapy. Yes Knockdown of circ_0000745 repressed proliferation, migration, invasion, and glycolysis of CC cells. 32644859 hsa_circ_0023404 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells Interaction(miR-636) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay//EdU Staining//Transwell Assay circ_0023404 and CYP2S1 expression were increased, and miR-636 was decreased in cervical cancer tissues and cells. Yes Moreover, circ_0023404 knockdown could repress proliferation, migration, invasion, and promote apoptosis of cervical cancer cells in vitro. Mechanically, circ_0023404 could regulate CYP2S1 expression by sponging miR-636. 34825467 circYPEL2 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissue and CC cell lines Expression [highly expressed] qPCR//Migration Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay CircYPEL2 exhibited significantly high expression in CC tissue and strong stability in CC cell lines. Yes Furthermore, knockdown and overexpression of circYPEL2 indicated the potential involvement in CC proliferation, migration and invasion. Finally, the downstream regulatory genes of circYPEL2 were investigated by knockdown experiment in CC cell lines with high-throughput sequencing. 35052380 LOC389332 LncRNA Homo sapiens microinvasive gastric cancer EGC tissues Expression[highly expressed] CCK8//qRT-PCR//Wound Healing Assay The results in the validation phase revealed that LOC389332 was remarkably overexpressed in gastric carcinoma tissues, precancerous lesions, and gastric cancer cells Yes Functional study showed that knockdown of LOC389332 expression could inhibit cell proliferation and migration. LncRNA expression microarray on the LOC389332 knockdown cell line model revealed that 393 mRNAs were differentially expressed. 31884510 circPGAP3 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Interaction(miR-769-5p/p53 axis) In Vivo Experiment//RNA Pull-Down//Transfection//Immunoblotting//CCK8//qRT-PCR//FISH//Luciferase Report Assay//ChIP we found a circRNA derived from PGAP3, referred as circ-PGAP3 (hsa_circ_0106800, chr17:37843549-37844086), which was significantly downregulated in CC tissues. Low circ-PGAP3 was closely linked to poor prognosis. Yes And overexpression of circ-PGAP3 significantly reduced CC cell proliferation in vitro and tumor growth in vivo. In terms of mechanism, circ-PGAP3 was transcriptionally elevated by p53, a well-recognized tumor suppressor, and circ-PGAP3 was located in the cytoplasm where sponged miR-769-5p to increase the levels of p53 and its downstream targets. 33591461 circARHGAP12 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissue and cells Interaction(m6A/FOXM1 manner) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//MeRIP//CCK8//qRT-PCR//FISH//RIP In the present study, our sequencing data revealed that a novel m6A-modified circRNA (circARHGAP12, hsa_circ_0000231) upregulated in the cervical cancer tissue and cells. Interestingly, the m6A modification of circARHGAP12 could amplify its enrichment. Yes Functional experiments illustrated that circARHGAP12 promoted the tumor progression of cervical cancer in vivo and vitro. 34392306 hsa_circ_101996 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction(miR-1236-3p/TRIM37 axis) Western Blot//ISH//Wound Healing Assay//CCK8//RIP//Survival Analysis//Luciferase Report Assay//Cell Cycle Assay Our results in this study suggested that circRNA_101996 was over-expressed in cervical cancer patients. The molecular investigations indicated that circRNA_101996 could increase the expression level of miR-1236-3p, tripartite motif-containing 37 (TRIM37), through binding to miR-1236-3p and reducing its expression. Yes circRNA_101996 up-regulation remarkably assisted cell proliferation, cell cycle progression, and cell migration in cervical cancer, while circRNA_101996 knockdown exerted the inverse effects.  33728810 circZFR CircRNA Homo sapiens Uterine Cervical Neoplasms  Cervical cancer tissues Expression [highly expressed] circRIP//Western Blot//Co-IP//qRT-PCR//Cell Proliferation Assay//Cell Cycle Assay//IHC We identified the circRNA signature of upregulated circRNAs between cervical cancer and paired adjacent normal tissues. Functionally, circZFR knockdown represses the proliferation, invasion, and tumor growth. Furthermore, circRNA pull-down experiments combined with mass spectrometry unveil the interactions of circZFR with Single-Stranded DNA Binding Protein 1 (SSBP1). Mechanistically, circZFR bound with SSBP1, thereby promoting the assembly of CDK2/cyclin E1 complexes. The activation of CDK2/cyclin E1 complexes induced p-Rb phosphorylation, thus releasing activated E2F1 leading to cell cycle progression and cell proliferation. Clinicopathological features of 40 cervical cancer patients (30 with and ten without paired normal tissues) showed that increased expression of circZFR was positively associated with lymphatic metastasis (Table ​(Table1,1, P =0.049), squamous cell carcinoma antigen (SCC Ag) value (Table ​(Table1,1, P =0.049), and Ki67 value (Table ​(Table1,1, P =0.003). However, circZFR was not associated with age, tumor stage, invasion depth, or vascular invasion Yes Functionally, circZFR knockdown represses the proliferation, invasion, and tumor growth. 33516252 hsa_circ_CSPP1 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues regulation[PI3K-Akt Signaling Pathway] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Hsa_circ_CSPP1 and ITGB1 were high-expressed in cervical cancer, while miR-361-5p was low-expressed. Circular RNA hsa_circ_CSPP1 regulates cell migration and proliferation in cervical cancer through miR-361-5p/ITGB1 in PI3K-Akt signaling pathway. Yes Hsa_circ_CSPP1 knockdown or miR-361-5p overexpression could suppress cervical cancer cell proliferation and migration, whereas promoted cell apoptosis. 32046405 hsa_circ_0000388 CircRNA Homo sapiens Uterine Cervical Neoplasms CC clinical samples regulation[miR-337-3p/ TCF12 Axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay Circ_0000388 expression in CC clinical samples was upregulated and this was correlated with unfavorable pathological indexes.Circ_0000388 was a novel oncogenic circRNA in CC, and promoted cancer progression via regulating miR-337-3p and TCF12, and could be potentially used as a diagnostic biomarker and therapy target. Yes Circ_0000388 remarkably enhanced the proliferation and metastasis of CC cells. 32119786 loc339803 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-30a-5p/ SNAIL1 axis) CCK8//qRT-PCR//EdU Staining The expression of loc339803 was upregulated in HCC tissues and cell lines, and positively correlated with tumor size, advanced tumor stage, higher serum AFP level and poor prognosis of HCC patients. Further studies demonstrated that loc339803 functioned as a competing endogenous RNA (ceRNA) by directly binding to miR-30a-5p, thus up-regulating the expression of SNAIL1, a target gene of miR-30a-5p. The expression of loc339803 was upregulated in HCC tissues and cell lines, and positively correlated with tumor size, advanced tumor stage, higher serum AFP level and poor prognosis of HCC patients. Yes Loc339803 can promote the migration and invasion of HCC cells in vivo and in vitro. 33442404 LOC339524 LncRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cells (J82, T24, UM-UC-3 and 5637) Interaction(miR-875-5p/COPS7A signaling axis) qRT-PCR//Luciferase report assay//Western Blot It was found that LOC339524 expression levels were markedly downregulated in BCa tissues and cells (J82, T24, UM-UC-3 and 5637).In conclusion, the findings of the present study suggested that LOC339524 may inhibit cell proliferation in BCa by targeting the miR-875-5p/COPS7A signaling axis. Yes LOC339524 overexpression was revealed to suppress the proliferation of BCa cells. 34584547 circAGFG1 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines regulation[downregulating p53] CCK8//qRT-PCR//RIP//EdU Staining//ChIP CircAGFG1 was upregulated in CC tissues and cell lines. CircAGFG1 is upregulated in CC. By recruiting EZH2, circAGFG1 downregulates p53 and thus exerts a carcinogenic role to accelerate the malignant progression of cervical cancer. Besides, the circAGFG1 level was closely related to worse tumor staging, a higher rate of metastasis, and larger tumor size in CC patients. Yes The knockdown of circAGFG1 attenuated the proliferative ability of SiHa and HeLa cells. 32141537 hsa_circ_103973 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissue samples and cell lines interaction[miR-335] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay Circ_103973 was found to be highly expressed in both GSE102686 and GSE113696 datasets as well as in CC tissue samples and cell lines. Higher levels of circ_103973 were correlated to a worse outcome of CC patients. Yes Knockdown of circ_103973 significantly promoted CC cell apoptosis and inhibited CC cell proliferation in vitro. 32184614 hsa_circ_0031288 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cells and tissue regulation[Hsa_circ_0031288/hsa-miR-139-3p/Bcl-6 regulatory feedback] qRT-PCR//Wound Healing Assay//RNA Pull-Down//Transwell Assay hsa_circ_0031288 and B-cell CLL/lymphoma 6 (Bcl-6) exhibited high expression in cervical cancer cells and tissue, while hsa-miR-139-3p exhibited low expression.In the cervical cancer HeLa cell line, the hsa_circ_0031288/hsa-miR-139-3p/Bcl-6 regulatory axis affects cell migration and proliferation, and its mechanism may involve hsa_circ_0031288 acting as a sponge for hsa-miR-139-3p, thereby relieving the transcriptional inhibition of Bcl-6. Yes Reducing hsa_circ_0031288 and Bcl-6 expression or increasing hsa-miR-139-3p expression significantly inhibited the migration, invasion, proliferation, and growth of xenograft and HeLa cells. 32277518 hsa_circ_9119 CircRNA Homo sapiens Uterine Cervical Neoplasms CC cells and tissues interaction[miR-126/MDM4] qRT-PCR circ9119 and MDM4 were initially overexpressed, and miR-126 expression was found to be reduced in CC cells and tissues.The dual-luciferase reporter assay highlighted that circ9119 functioned as an miR-126 ceRNA to increase MDM4 expression. Yes A series of mimics, inhibitors, overexpressing plasmids or siRNAs were introduced into CC cells to alter the circ9119, miR-126, and MDM4 expressions. Cell-based experiments showed that silencing of circ9119 or the upregulation of miR-126 resulted in suppressed proliferation, accompanied by the induced apoptosis of CC cells. 32385717 circNRIP1 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues regulation[PTP4A1/ERK1/2 pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay QRT-PCR confirmed that circNRIP1 was upregulated in CC tissues, where its expression was correlated with lymphovascular space invasion. Finally, we confirmed that circNRIP1 exerts its effect, at least partially, by sponging miR-629-3p and thereby regulating the PTP4A1/ERK1/2 pathway. Yes Besides, both in vitro and in vivo experiments demonstrated that circNRIP1 promotes cell proliferation, migration, and invasion. 32457332 hsa_circ_0008285 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines regulation[miR-211-5p/SOX4 Axis] qRT-PCR//Luciferase Report Assay//RIP In the present study, we identified a new circRNA hsa_circ_0008285, which was significantly up-regulated in CC tissues and cell lines. Therefore, our research highlighted that hsa_circ_0008285 promoted CC progression via serving as a ceRNA of miR-211-5p to release SOX4, which might provide a potential therapeutic target for tumor treatment. Yes Loss-of-function assays showed that hsa_circ_0008285 suppression reduced the proliferation and invasion of CC cells in vitro and reduced tumor growth in vivo. 32547228 hsa_circ_0000520 CircRNA Homo sapiens Uterine Cervical Neoplasms interaction[binding with miR-146b-3p] Western Blot//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that hsa_circ_0000520(circ_0000520) was decreased in CC tissues and cell lines.Mechanismly, circ_0000520 and PAX5 were revealed to directly bind to miR-146b-3p, and circ_0000520 could indirectly regulate PAX5 by sponging miR-146b-3p. Yes Functional studies indicated circ_0000520 overexpression in vitro repressed CC cell proliferation, invasion and migration, while promoted CC cell apoptosis. 32592222 hsa_circ_101308 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Expression[lower expressed] qRT-PCR//RNA Pull-Down//Transwell Assay CircRNA_101308 was significantly downregulated in CC tissues. The level of circRNA_101308 was much lower in CC patients with lymph node metastasis or deep myometrial invasion compared to those patients without lymph node metastasis and superficial myometrial invasion. Yes CircRNA_101308 overexpression inhibited CC cell proliferation, invasion and migration. 32606970 hsa_circ_0000745 CircRNA Homo sapiens Uterine Cervical Neoplasms cc tissues Interaction[E-cad] qRT-PCR//Western Blot//Transwell Assay//Microarray hsa_circ_0000745 was Expression[up-expression]regulated in CC, and its level positively correlated with the level of its linear messenger RNA isoform. Yes The role of hsa_circ_0000745 was illuminated by knocking down hsa_circ_0000745 in CC cells, and the results revealed that reducing hsa_circ_0000745 inhibited cell proliferation, migration, and invasion in CC by Expression[up-expression]regulating E-cadherin (E-cad) expression. 31256433 hsa_circ_0000263 CircRNA Homo sapiens Uterine Cervical Neoplasms cell lines( HeLa, CaSki, SiHa, C‐33A, and SW756) Interaction[TGF-β1] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay By using western blot and immunohistochemistry, we confirmed that hsa_circ_0000263 can regulate the expression of murine double minute 4 (MDM4) by affecting miR-150-5p, and finally affect the expression of p53 gene. We found that hsa_circ_0000263 was significantly Expression[Expression[up-expression]-expression]regulated in cervical cancer cells. In addition, the knockExpression[down-expression] of hsa_circ_0000263, would inhibit cell proliferation and migration ability. Yes In addition, the knockExpression[down-expression] of hsa_circ_0000263, would inhibit cell proliferation and migration ability. 30569515 lncRP5 LncRNA Homo sapiens ovarian carcinoma OC patients and cell lines Interaction(lncRP5/miR-545-5p/PTP4A1 axis ) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay RT-qPCR shows lncRP5 is significantly upregulated in OC patients and cell lines, and it is mainly located in the cytoplasm of OC cells.Moreover, the binding relationship between lncRP5 and miR-545-5p is predicted by bioinformatics and is further verified by luciferase assay. Functionally, the regulatory effects of lncRP5 and miR-545-3p are negatively related; miR-545-5p serves as a tumor suppressor in OC. Further studies demonstrate that PTP4A1 is the target gene of miR-545-5p. Overexpression of PTP4A1 abrogates the inhibitory function of miR-545-5p on OC cell growth and metastasis. Yes The results of CCK-8, colony formation, and transwell assays demonstrate that overexpression of lncRP5 greatly contributes to malignant behaviors of OC cells, while inhibition of lncRP5 shows the opposite effects. 35538027 LOC100127888 LncRNA Homo sapiens Colorectal Neoplasms CRC cancer tissues Expression(highly expressed) CCK8//Transwell Assay//IHC//Microarray The expression of LncA was significantly upregulated in CRC cancer tissues compared with the corresponding noncancer tissues. High LncA expression in cancer tissues was associated with pathological classification, depth of invasion, lymph node metastasis, TNM stage and distant metastasis. LncA expression was an unfavorable prognostic factor for CRC patients. Furthermore, LncA combined with clinical variables exhibited synergistic potential for the prediction of CRC prognosis. Yes Low expression of LncA in HT 29 and HCT116 cells could decrease cell proliferation, and the migration and invasion of these cells was inhibited by knockdown of LncA. 34991861 LNMAS LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cells Interaction(HMGB1/TWIST1 and STC1) In Vivo Experiment//Western Blot//ISH//Transfection//Wound Healing Assay//qRT-PCR//RNA-seq In this study, we identified a lncRNA termed lymph node metastasis associated suppressor (LNMAS), which was downregulated in LN-positive cervical cancer patients and correlated with LN metastasis and prognosis. Mechanistically, LNMAS exerts its metastasis suppressive activity by competitively interacting with HMGB1 and abrogating the chromatin accessibility of TWIST1 and STC1, inhibiting TWIST1-mediated partial EMT and STC1-dependent immune escape from macrophage phagocytosis. We further demonstrated that the CpG sites in the promoter region of LNMAS was hypermethylated and contributed to the downregulation of LNMAS. Yes Functionally, LNMAS suppressed cervical cancer cells metastasis in vitro and in vivo. 35152264 lnc-XR_003496198 LncRNA Homo sapiens Duck Hepatitis A Virus Type 1 (Dhav-1) DHAV-1-infected duck embryo fibroblasts Regulation qRT-PCR//Western Blot Functional annotation analyses indicated that the putative target genes of DELs participated in diverse vital biological processed, including immune responses, cellular metabolism, and autophagy. For example, we confirmed the dysregulation of pattern recognition receptors (TLR3, RIG-I, MDA5, LGP2, cGAS), signal transducers (STAT1), transcription factors (IRF7), immune response mediators (IL6, IL10, TRIM25, TRIM35, TRIM60, IFITM1, IFITM3, IFITM5), and autophagy-related genes (ULK1, ULK2, EIF4EBP2) using RT-qPCR. Finally, we confirmed that one DHAV-1 induced lncRNA-XR_003496198 is likely to inhibit DHAV-1 replication in DEFs. Our study comprehensively analyzed the lncRNA profiles upon DHAV-1 infection and screened the target genes involved in the innate immune response and autophagy signaling pathway, thereby revealing the essential roles of duck lncRNAs and broadening our understanding of host-virus interactions. Yes inally, we confirmed that one DHAV-1 induced lncRNA-XR_003496198 is likely to inhibit DHAV-1 replication in DEFs. 35531338 lncWDR26 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells interaction[SIX3] RNA Pull-Down//Western Blot//qRT-PCR//Cell Cycle Assay//ChIP Here, we reported that lncWDR26 was significantly downregulated in HCC tissues and cells.Mechanistically, lncWDR26 suppressed HCC growth and metastasis by inhibiting WDR26 transcription. Notably, lncWDR26 was associated with SIX homeobox 3 (SIX3), and this association was required for the repression of WDR26 transcription. Moreover, decreased lncWDR26 expression correlates with larger tumor size, higher clinical stage, and tumor metastasis, and also predicts poor prognosis in patients with HCC. Yes In HCC cells, overexpression of lncWDR26 inhibited growth and metastasis, both in vitro and in vivo. 29736313 lnc-W5 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines and tissues Expression [lower expressed] In Vivo Experiment//Migration Assay//CCK8//Colony Formation Assay//Invasion Assay The results showed that lncRNA W5 expression was significantly downregulated in HCC cell lines and tissues. In vitro experiments showed that ectopic overexpression of lncRNA W5 suppressed HCC cell proliferation, migration and invasion; conversely, silencing of lncRNA W5 promoted cell proliferation, In addition, acting as a tumor suppressor gene in HCC, lncRNA W5 inhibited the growth of HCC xenograft tumors in vivo. Yes In vitro experiments showed that ectopic overexpression of lncRNA W5 suppressed HCC cell proliferation, migration and invasion; conversely, silencing of lncRNA W5 promoted cell proliferation, In addition, acting as a tumor suppressor gene in HCC, lncRNA W5 inhibited the growth of HCC xenograft tumors in vivo. 33505150 lnc-UCID LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and HCC cell lines Regulation(Stabilization of Snail) qRT-PCR//Western Blot "Lnc-UCID was upregulated in human HCC tissues and HCC cell lines. The expression of Snail positively correlated with lnc-UCID abundance, and the interaction between lnc-UCID and Snail mRNA prevented miR-122, miR-203, miR-30b, miR-34a or miR-153 binding to the 3'-UTR of Snail. Transfection of Snail greatly rescued the migration and invasion of HCC cells. " Yes Lnc-UCID promoted the cells' mobility and invasiveness by enhancing the EMT process of HCC cells. 33536764 lncTSI LncRNA Homo sapiens Aortic Valve, Calcification of valve interstitial cells Regulation(TGF-β/Smad3 pathway) In Vivo Experiment//Western Blot//FISH//Luciferase Report Assay//IHC//ChIP lncTSI was highly expressed in VICs treated with TGF-β1.lncTSI was transcriptionally regulated by Smad3 and reversely inhibited TGF-β1-induced Smad3 phosphorylation and downregulated profibrotic gene expression. Silencing lncTSI increased TGF-β1-induced Smad3 phosphorylation, and subsequently, upregulated RUNX2 and collagen I expressions in VICs. While overexpression of lncTSI reversed the production of RUNX2 and collagen I in VICs. In a mouse CAVD model of 24 week 0.25 % high-cholesterol diet feeding, overexpression of lncTSI significantly reduced calcium deposition, RUNX2, pSmad3, and collagen I expression in aortic valve leaflets, with less aortic valve stenosis. Yes Silencing lncTSI increased TGF-β1-induced Smad3 phosphorylation, and subsequently, upregulated RUNX2 and collagen I expressions in VICs. While overexpression of lncTSI reversed the production of RUNX2 and collagen I in VICs. In a mouse CAVD model of 24 week 0.25 % high-cholesterol diet feeding, overexpression of lncTSI significantly reduced calcium deposition, RUNX2, pSmad3, and collagen I expression in aortic valve leaflets, with less aortic valve stenosis. 36273649 lnc-TRAF1-4:1 LncRNA Homo sapiens Arthritis, Rheumatoid chondrocyte Interaction(miR-27a-3p/CXCL1 ) Western Blot//qRT-PCR//RNA-seq//Cell Cycle Assay//Transwell Assay Mechanistically, lnc-TRAF1-4:1 upregulated CXCL1 expression through sponging miR-27a-3p as a competing endogenous RNA (ceRNA) in chondrocytes identifying by Dual-luciferase reporter gene assay. Summarily, exosomal lncRNA TRAFD1-4:1 derived from RA-FLSs suppressed chondrocyte proliferation and migration through degrading CECM by upregulating CXCL1 as a sponge of miR-27a-3p. Yes Besides, RNA sequencing and verification by qRT-PCR revealed that exosomal long non-coding RNA (lncRNA) tumor necrosis factor-associated factor 1 (TRAF1)-4:1 derived from RA-FLSs treated with TNFα was a candidate lncRNA, which also inhibited chondrocyte proliferation and migration through degrading CECM. 36481205 lnc-TDRG1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(miR-214-5p/SEMA4C axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Invasion Assay We found Lnc-TDRG1 was highly expressed in CC tissues and cells and it was upregulated in response to hypoxia. Yes Loss-of-functional experiment suggested that knockdown of lnc-TDRG1 impede invasion, hypoxia-induced glycolysis in vitro and tumor growth in vivo, which was abolished by knockdown of miR-214-5p or overexpression of SEMA4C. 33394293 lnc-TCF7 LncRNA Homo sapiens Multiple Myeloma MM tissues and cell lines Interaction( miR-203/Jagged1-Notch1 signaling pathway) qRT-PCR//Western Blot lnc-TCF7 expression was increased in patients with MM compared with the healthy controls and was positively related to β-2-microglobulin expression and International Staging System stage, while negatively associated with complete response, EFS and OS. In vitro, lnc-TCF7 was upregulated in MM cells compared with normal bone marrow plasma cells, and its knockdown suppressed MM cell proliferation while promoting apoptosis. Compensation experiments showed that miR-203 inhibition promoted MM progression by regulating the Jagged1-Notch1 signaling pathway in lnc-TCF7-knockdown cells. lnc-TCF7 expression was increased in patients with MM compared with the healthy controls and was positively related to β-2-microglobulin expression and International Staging System stage, while negatively associated with complete response, EFS and OS. Yes In vitro, lnc-TCF7 was upregulated in MM cells compared with normal bone marrow plasma cells, and its knockdown suppressed MM cell proliferation while promoting apoptosis. Compensation experiments showed that miR-203 inhibition promoted MM progression by regulating the Jagged1-Notch1 signaling pathway in lnc-TCF7-knockdown cells. 33841573 lnc-STYK1-2 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction(miR-146b-5p /ITGA2 / AKT/STAT3/NF-kB signaling) qRT-PCR//Bioinformatics Analysis Alterations in lncRNA profiles, including decreased lnc-STYK1-2 expression, were detected in bladder cancer tissues compared with adjacent noncancerous tissues. lnc-STYK1-2 siRNA promoted miR-146b-5p and reduced ITGA2 expression in bladder cancer cells. Moreover, miR-146b-5p suppressed ITGA2 expression in bladder cancer cells through direct association. Also, lnc-STYK1-2 directly associated with miR-146b-5p. Finally, miR-146b-5p inhibitors abrogated the alterations in bladder cell functions, ITGA2 expression, and phosphorylation of AKT, STAT3, and P65 proteins in 5637 and T24 cells induced by lnc-STYK1-2 silencing. Yes lnc-STYK1-2 silencing effectively promoted proliferation, migration, and invasion in two bladder cancer cell lines, 5637 and T24, and their tumorigenesis in nude mice. 34332611 lnc-Sox2ot LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC cells Interaction(miR-200/Sox2) qRT-PCR//RIP We identified a lncRNA-Sox2ot from exosomes of highly invasive PDAC cells, and analyzed the expression of Sox2ot in the plasma samples and found that the plasma exosomal Sox2ot expression was high and correlated with TNM stage and overall survival rate of PDAC patients. Sox2ot competitively binds to the miR-200 family to regulate the expression of Sox2, thus promoting invasion and metastasis of PDAC. Further research showed that Sox2ot promotes epithelial-mesenchymal transition (EMT) and stem cell like properties by regulating Sox2 expression. We identified a lncRNA-Sox2ot from exosomes of highly invasive PDAC cells, and analyzed the expression of Sox2ot in the plasma samples and found that the plasma exosomal Sox2ot expression was high and correlated with TNM stage and overall survival rate of PDAC patients. Yes We also confirmed the transmission of the exosomes from producer cells to recipient PDAC cells, exosomal Sox2ot can promote tumor invasion and metastasis in vitro and in vivo. We further confirmed tumor generated exosomes could excrete to tumor cell or blood circulation in vivo condition. 29643475 LncSNHG16 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction[targeting microRNA-146a-5p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay LncSNHG16 was highly expressed in OS tissues and cell lines. LncSNHG16 is highly expressed in OS tissues and cell lines, participating in the development of OS by downregulating microRNA-146a-5p to upregulate NOVA1 expression. Its expression was positively correlated with the tumor stage of OS patients.Receiver operating characteristic (ROC) curves suggested that lncSNHG16 can be used as a clinical indicator to distinguish OS patients from healthy controls. Survival analysis indicated a negative correlation between lncSNHG16 expression and survival of OS patients. Yes Overexpression of lncSNHG16 enhanced the proliferative and migratory potentials of OS cell lines 143B and MNNG/HOS. 30657551 lncSNHG15 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[absorbing miR-211-3p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The expression of lncSNHG15 in NSCLC tissues was significantly higher than that of para-cancerous tissues.High expression of lncSNHG15 promoted the proliferation and migration of NSCLC cells by upregulating ZNF217 by adsorbing miR-211-3p. In particular, the expression of lncSNHG15 in NSCLC patients with stage III-IV was higher than those with stage I-II. Yes lncSNHG15 over-expression remarkably promoted the proliferation and migration of NSCLC cells (A549 and H358). 30840276 LncSNHG1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-181b-5p/SMAD2 axis) qRT-PCR//Western Blot//Luciferase Report Assay//Colony Formation Assay LncSNHG1 was overexpressed both in CRC tissues and cell lines, while the miR-181b-5p expression was decreased in CRC cell lines. Meanwhile, LncSNHG1 enhanced EMT progress through regulation of the miR-181b-5p/SMAD2 axis. Yes After knock-down of LncSNHG1, the proliferation, invasion, and migration of HT29 and SW620 cells were all decreased. 35310912 lncSLCO1C1 LncRNA Homo sapiens Stomach Neoplasms GC tissue and cells Interaction(miR-211-5p and miR-204-5p/SSRP1 ) RNA Pull-Down//Western Blot//Co-IP//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay LncSLCO1C1 was highly upregulated in GC tissue samples and associated with GC patients' poor overall survival. . Mechanistically, lncSLCO1C1 serves as a scaffold for the structure-specific recognition protein 1 (SSRP1)/H2A/H2B complex and regulates the function of SSRP1 in reducing DNA damage. Meanwhile, lncSLCO1C1 functions as a sponge to adsorb miR-204-5p and miR-211-5p that target SSRP1 mRNA, and thus increases SSRP1 expression. Meanwhile, lncSLCO1C1 functions as a sponge to adsorb miR-204-5p and miR-211-5p that target SSRP1 mRNA, and thus increases SSRP1 expression. LncSLCO1C1 was highly upregulated in GC tissue samples and associated with GC patients' poor overall survival. Patients with high expressions of both lncSLCO1C1 and SSRP1 have poor overall survival, highlighting the role of lncSLCO1C1 in GC progression. Yes LncSLCO1C1 was highly upregulated in GC tissue samples and associated with GC patients' poor overall survival. 35474446 Lnc-SLC4A1-1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines,blood Interaction[NF-κB/CXCL8] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Transwell Assay Lnc-SLC4A1-1 was significantly up-regulated in BC tissue, serum samples and cell lines. Lnc-SLC4A1-1 interacted with NF-κB to promote CXCL8 expression. Lnc-SLC4A1-1 could promote the development of BC. Yes In BC cells, lnc-SLC4A1-1 knockdown promoted cell apoptosis and suppressed cell proliferation, migration and invasion. 31556319 Lnc-SELPLG-2:1 LncRNA Homo sapiens Osteosarcoma osteosarcoma cells and samples Interaction(hsa-miR-10a-5p/BTRC ) qRT-PCR//RNA-seq Lnc-SELPLG-2:1 was highly expressed in osteosarcoma compared to normal cells and bone and marrow samples. The prediction, dual luciferase assay, and response test results indicated that hsa-miR-10-5p and BTRC were involved in the lnc-SELPLG-2:1 cascade. Unlike lnc-SELPLG-2:1, hsa-hsa-miR-10a-5p had opposite expression and function. Competitive binding of lnc-SELPLG-2:1 to hsa-hsa-miR-10a-5p prevented BTRC from miRNA-mediated degradation, thereby activating the expression of VIM, MMP9, and MMP2, promoting osteosarcoma cell proliferation, migration, and invasion, and inhibiting apoptosis. Yes Inhibition of lnc-SELPLG-2:1 accelerated cell apoptosis and suppressed cell proliferation, migration, and invasion, whereas lnc-SELPLG-2:1 overexpression had the opposite effect.Moreover, inhibiting lnc-SELPLG-2:1 in an in vivo model decreased tumor size and suppressed the expression of cell migration-related proteins. 36199080 Lnc-S100B-2 LncRNA Homo sapiens Colorectal Neoplasms CRC cells Regulation(MLLT10) Western Blot//qRT-PCR//Luciferase Report Assay//IHC//IF Lnc-S100B-2 was obtained, and high expression of Lnc-S100B-2 was predicted to be associated with a lower survival rate. At the gene and protein levels, the expressions of PCNA, Ki67, and Bcl-2 were decreased in the sh-Lnc-S100B-2 group, sh-MLLT10 group, and sh-Lnc-S100B-2 + sh-MLLT10 group, while the expressions of cleaved caspase 3, caspase 9, and Bax were increased. In vivo, the volume and mass of the tumor decreased in the sh-Lnc-S100B-2 + sh-MLLT10 group. Lnc-S100B-2 was obtained, and high expression of Lnc-S100B-2 was predicted to be associated with a lower survival rate. Yes After silencing Lnc-S100B-2 and MLLT10, the proliferative activity of CRC cells decreased, and the apoptosis rate increased. 35126515 lncRsp1 LncRNA Homo sapiens Fusarium graminearum putative sugar transporter gene Regulation(Fgsp1) qRT-PCR In our previous RNA sequencing (RNA-Seq) study, we discovered that lncRsp1 is an lncRNA that is located +99 bp upstream of a putative sugar transporter gene, Fgsp1, with the same transcription direction. Functional studies revealed that ΔlncRsp1 and ΔFgsp1 were normal in growth and conidiation but had defects in ascospore discharge and virulence on wheat coleoptiles. Moreover, lncRsp1 and Fgsp1 were shown to negatively regulate the expression of several deoxynivalenol (DON) biosynthesis genes, TRI4, TRI5, TRI6, and TRI13, as well as DON production. Further analysis showed that the overexpression of lncRsp1 enhanced the ability of ascospore release and increased the mRNA expression level of the Fgsp1 gene, while lncRsp1-silenced strains reduced ascospore discharge and inhibited Fgsp1 expression during the sexual reproduction stage. In addition, the lncRsp1 complementary strains lncRsp1-LC-1 and lncRsp1-LC-2 restored ascospore discharge to the level of the wild-type strain PH-1. Yes Further analysis showed that the overexpression of lncRsp1 enhanced the ability of ascospore release and increased the mRNA expression level of the Fgsp1 gene, while lncRsp1-silenced strains reduced ascospore discharge and inhibited Fgsp1 expression during the sexual reproduction stage. I 34841640 LNRRIL6 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction[ IL-6/STAT3 pathway] CCK8//qRT-PCR//Western Blot In this study, we report the identification of a novel lncRNA, named long noncoding RNA regulating IL-6 transcription (LNRRIL6), which is upregulated in CRC tissues and cell lines. Taken together, these findings identify a novel lncRNA, LNRRIL6, that promotes CRC cell survival through activation of the IL-6/STAT3 pathway and suggest that LNRRIL6 may be a potential prognostic biomarker and therapeutic target for CRC. Yes Functional experiments showed that enhanced expression of LNRRIL6 promotes CRC cell proliferation and survival in vitro and CRC tumor growth in vivo. Conversely, depletion of LNRRIL6 inhibits CRC cell proliferation and survival in vitro and CRC tumor growth in vivo. 31246342 LOC100129620 LncRNA Homo sapiens Osteosarcoma hBMSCs Interaction(miR-335-3p) qRT-PCR//Western Blot The results show that LOC100129620 can promote the proliferation and migration of osteosarcoma cells. LOC100129620 can promote the proliferation of osteosarcoma in vivo. LOC100129620 can bind to miR-335-3p and regulate its function. MiR-335-3p mediates the regulatory effects of LOC100129620 on CDK6. Yes The results show that LOC100129620 can promote the proliferation and migration of osteosarcoma cells. LOC100129620 can promote the proliferation of osteosarcoma in vivo. 34015762 hsa_circ_101996 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues,cell lines( SiHa, C33A, CaSki, and Hela) Interaction[HOTAIR,TPX2 ] CCK8//qRT-PCR//Luciferase Report Assay ". Besides, hsa_circR_x0002_NA_101996 expression in cervical cancer tissues was much higher compared with adjacent normal tissues (Figure 1b), and much higher in cervical cancer cell lines compared with human cervical epithelial cells.Mechanistically, we demonstrated that hsa_circRNA_101996 served as a sponge of miR-8075, which targeted TPX2 in cervical cancer cells." Yes We found that knockExpression[down-expression] of hsa_circRNA_101996 significantly inhibited the proliferation, cell cycle, migration, and invasion of cervical cancer cells. 30633364 LOC100130075 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells Interaction(E2F1/MDM2 ) RNA Pull-Down//Western Blot//Transfection//Tunel//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//ChIP The high expression pattern of LOC100130075 and MDM2 and a positive correlation between them were firstly verified in CC cells. Furthermore, we verified through mechanism assays including ChIP, RNA pull-down, as well as luciferase reporter assays that LOC100130075 bound to E2F transcription factor 1 (E2F1) to activate MDM2 transcription. Furthermore, the result of rescue assays manifested that MDM2 overexpression reversed the inhibitory function of LOC100130075 deficiency on CC development. Yes Then, it was verified that LOC100130075 interference suppressed the proliferation and enhanced the apoptosis of CC cells. 35201567 LOC105374902 LncRNA Homo sapiens Uterine Cervical Neoplasms cell line Interaction[as a sponge of miR-1285-3p] Northern Blot//Western Blot//qRT-PCR//Luciferase Report Assay//Transwell Assay We characterized a significantly upregulated lncRNA LOC105374902 induced by TNF-α. Then, we found that TNF-α accelerated the binding of STAT3 to the promoter region of lncRNA LOC105374902 and promoted its expression. Mechanistically, lncRNA LOC105374902 directly bond to miR-1285-3p as a competing endogenous RNA (ceRNA) to derepress RPL14 Yes functional analysis indicated that both lncRNA LOC105374902 and RPL14 promoted migration, invasion and epithelial-mesenchymal transition (EMT) of CC cells. 30935691 LOC105372579 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation[miR-4316/FOXP4 signaling ] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay LOC105372579 was highly expressed in HCC tissues and cell lines.Thus, our findings supported that LOC105372579 contributes to HCC cell proliferation, migration, invasion, and EMT by activating miR-4316/FOXP4 signaling. Yes LOC105372579 silencing suppressed the proliferation of HCC cells in vitro. We also validated that LOC105372579 knockdown inhibited the migration, invasion, and epithelial-mesenchymal transition of HCC cells. Xenograft assay demonstrated that LOC105372579 promotes tumor growth in vivo. 31114338 LOC102724163 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction((miR)-508-5p/MUC19 ) CCK8//qRT-PCR//Wound Healing Assay//Invasion Assay In the present study, analysis of The Cancer Genome Atlas database and reverse transcription-quantitative PCR demonstrated that LOC102724163 expression levels were significantly upregulated in BC tissues compared to matched adjacent normal tissues and were associated with an unfavorable prognosis in patients with BC. In the mechanistical aspect, LOC102724163 sponged microRNA (miR)-508-5p to elevate MUC19 expression. Additionally, rescue assays ascertained the function of the LOC102724163/miR-508-5p/MUC19 axis in the proliferation and invasion of BC cells. In the present study, analysis of The Cancer Genome Atlas database and reverse transcription-quantitative PCR demonstrated that LOC102724163 expression levels were significantly upregulated in BC tissues compared to matched adjacent normal tissues and were associated with an unfavorable prognosis in patients with BC. Yes Gain or loss of function assays indicated that overexpression of LOC102724163 significantly increased tumorgenicity in vivo and cell migration, proliferation and invasion in vitro. 35154431 LOC101929552 LncRNA Homo sapiens Osteosarcoma OS cells regulation[NR_136400/miR-8081/TUSC5 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, we demonstrated that NR_136400 was downregulated in OS cells and that its downregulation promoted OS cell proliferation, apoptosis, and invasion. Taken together, a newly identified regulatory mechanism of the lncRNA NR_136400/miR-8081/TUSC5 axis was systematically studied in OS, providing a promising target for therapeutic treatment. Yes In the present study, we demonstrated that NR_136400 was downregulated in OS cells and that its downregulation promoted OS cell proliferation, apoptosis, and invasion. 32499696 LOC101928963 LncRNA Homo sapiens Glioma glioma tissues Interaction[ Binding to PMAIP1 ] Flow Cytometry//qRT-PCR//MTT//Western Blot Decreased cell apoptosis and PMAIP1 expression, as well as overexpressed LOC101928963, were exhibited among spinal cord glioma tissues. The data obtained during the study highlighted the inhibitory role of LOC101928963 silencing in spinal cord glioma through the increase in PMAIP1, which suggests a potential target in the treatment of spinal cord glioma. Yes LOC101928963 overexpression was observed to promote cell proliferation and cell-cycle entry and inhibit the process of apoptosis. 31670198 LOC101928834 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow regulation[Wnt/β-catenin signaling pathway] qRT-PCR We identified a novel lncRNA, LOC101928834, which was significantly up-regulated in the bone marrow of patients with MDS and acute myeloid leukemia (AML). Moreover, functional analysis showed that LOC101928834 promoted cell proliferation and cell cycle progression, and activated Wnt/β-catenin signaling pathway in vitro. Yes Moreover, functional analysis showed that LOC101928834 promoted cell proliferation and cell cycle progression, and activated Wnt/β-catenin signaling pathway in vitro. 32463458 LOC101928477 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissue and ESCC cell lines Expression [lower expressed] Wound Healing Assay//Colony Formation Assay//qRT-PCR//FISH//Cell Viability Assay//IHC//IF We determined that LOC101928477 expression was inhibited in ESCC tissue and ESCC cell lines when compared with controls. Yes Moreover, forced expression of LOC101928477 effectively inhibited ESCC cell proliferation, colony formation, migration, and invasion via suppression of epithelial-mesenchymal transition (EMT). Furthermore, LOC101928477 overexpression inhibited in situ tumor growth and lung metastasis in a mouse model. 33713583 LOC101928316 LncRNA Homo sapiens Stomach Neoplasms GC tissues ,cell lines Regulation[PI3K-Akt-mTOR signaling pathway] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Transwell Assay In the present study, we have found that LOC101928316 was significantly downregulated in gastric cancer (GC) tissues specimen, GC cell lines. LOC101928316 molecular mechanism investigates suggested that LOC101928316 can regulate PI3K-Akt-mTOR signaling pathway and change the GC development progression in vivo and in vitro. In vivo experiment also revealed that LOC101928316-Overexpression can inhibit the tumorigenicity of GC cells in tumor-burdened experimental nude mice (P ＜ 0.05). LOC101928316 may function as anti-oncogene and also plays an important role in GC tumorigenesis. Collectively, our data provided the key role of LOC101928316 in the tumorigenesis of GC. In addition, the present study elucidates LOC101928316 potential regulatory network, which may help us to lead a better knowing of the pathogenesis of GC and probe the lncRNA as a novel biomarker to diagnosis and therapy for this malignant tumor. In the present study, we have found that LOC101928316 was significantly downregulated in gastric cancer (GC) tissues specimen, GC cell lines, and associated with the GC patients tumor, node, and metastasis (TNM) stage and degree of differentiation (P ＜ 0.05). Yes LOC101928316 overexpression can significantly inhibit SGC-7901 cell migration, invasion, and proliferation (P＜0.05). 31207155 LOC101928134 LncRNA Mus musculus Osteoarthritis knee joint synovial tissues Regulation[JAK/STAT signaling pathway] qRT-PCR LOC101928134, which was found to be highly expressed in knee joint synovial tissues of OA rats, regulated the expression of IFNA1 gene and inhibited JAK/STAT signaling pathway.These results demonstrate that downregulation of LOC101928134 suppresses the synovial hyperplasia and cartilage destruction of OA rats via activation of JAK/STAT signaling pathway by upregulating IFNA1, providing a new candidate for the treatment of OA. Yes Downregulation of LOC101928134 resulted in reduced knee joint synovitis, relived inflammatory damage, and knee joint cartilage damage of OA rats. 30456844 LOC101927746 LncRNA Homo sapiens Colorectal Neoplasms Interaction[ inhibiting miR-584-3p and activating SSRP1] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that LOC101927746 expression was significantly increased in CRC tissues according to the GEO dataset. In terms of its mechanism, LOC101927746 could serve as a competing endogenous RNA to inhibit miR-584-3p and activate its target gene SSRP1. The expression of miR-584-3p was inversely correlated with either LOC101927746 or SSRP1 in CRC tissues. The overexpression of SSRP1 or inhibition of miR-584-3p could reverse the effects of LOC101927746 knockdown in CRC cells. Taken together, our results suggest that the LOC101927746/miR-584-3p/SSRP1 axis modulates CRC progression. Yes Functionally, we demonstrated that LOC101927746 silencing significantly suppressed the proliferation, migration, and invasion of CRC cells. 30616889 LOC101927476 LncRNA Homo sapiens Ovarian Neoplasms metastatic tumors Regulation(GATA4) qRT-PCR//Wound Healing Assay RT-PCR assay showed that 20 out of 22 patients had significantly lower expression of LOC101927476 in their metastatic tumors compared with primary tumors. The relative expression of GATA4 in OE-LOC101927476 group was (1.86±0.25), significantly higher than 1.00 of OE-EV group (P=0.001). In patients with high expression of LncRNA LOC101927476, the expression level of GATA4 was (2.93±0.35), which was higher than (0.29±0.06) of LOC101927476 low expression group (P=0.001). Yes Transwell assay showed that overexpression of LOC101927476 significantly inhibited the invasion and migration capacities of 3AO cells. The numbers of invading and migrating 3AO cells infected with OE-LOC101927476 lentivirus were (357±63) and (699±65), respectively, lower than (661±95) and (1 024±76) in OE-EV group (P<0.050). In contrast, the numbers of invading and migrating OVCA429 cells with LOC101927476 knockdown were (512±72) and (472±40), respectively, higher than (309±13) and (363±27) in sg-Control group (P<0.050). Wound healing assay results showed that after 48 hours, the percentage of scratch healing of 3AO cells in OE-LOC101927476 group was (10.86±0.63)%, significantly lower than (57.38±4.42)% of OE-EV group (P=0.009). After 24 hours, the percentage of scratch healing of OCVA429 cells in sg-LOC101927476 group was (59.98±1.34)%, significantly higher than (23.15±2.03)% of sg-Control group (P=0.004). CCK-8 assays showed that the OD value of 3AO cells in OE-LOC101927476 group was (2.07±0.08), significantly lower than (2.29±0.04) of OE-EV group (P=0.009). The OD value of OVCA429 cells in sg-LOC101927476 group was (2.13±0.03), significantly higher than (1.93±0.03) of sg-Control group (P=0.001). 35073656 LOC100996425 LncRNA Homo sapiens Prostate 110 PCa tissue samples Interaction(HNF4A-mediated AMPK/mTOR pathway) Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//H&E Staining//IHC LOC100996425 was up-regulated, while HNF4A was down-regulated in the PCa tissues. HNF4A was a target gene of LOC100996425. The activation of AMPK pathway involved in the cancer progression mediated by LOC100996425. Down-regulation of LOC100996425 retards progression of PCa through HNF4A-mediated AMPK/mTOR pathway. Yes PCa cells transfected with either siLOC100996425 or HNF4A displayed reduced rates of PCa cell proliferation and migration while elevating cell apoptosis. 34309216 LOC100912373 LncRNA Mus musculus Arthritis, Rheumatoid synovial tissues,fibroblast-like synoviocytes regulation[PDK1,miR-17-5p] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay The results showed that lncRNA LOC100912373 localized in the cytoplasm and was highly expressed in the synovial tissues and FLSs of AA rats.In conclusion, lncRNA LOC100912373 may upregulate the expression of PDK1 by sponging miR-17-5p, accelerating the phosphorylation of AKT and inducing the proliferation of FLSs, thus promoting the occurrence and development of RA. Yes LncRNA LOC100912373 overexpression promoted the proliferation of FLSs. 33437356 LOC100911498 LncRNA Rattus norvegicus Neuralgia SNI rats Expression(highly expressed) In Vivo Experiment//qRT-PCR//IHC//Western Blot Our results suggested that the level of LOC100911498 in SNI rats was markedly higher than that in the sham group Yes the MWT values in rats were treated with LOC100911498siRNA were increased, and the expression levels of P2X4R, Iba-1, p-p38 and BDNF in SNI+ LOC100911498siRNA group were reduced compared with those in the SNI group. 33949153 LOC100507144 LncRNA Homo sapiens Colorectal Neoplasms tumors Interaction(CD44/Nanog/Sox2/miR-302/miR-21 axis) qRT-PCR//Transwell Assay//Western Blot Our expression data represented that the expression of LOC100507144 transcript was substantially higher in tumors with advanced stages, lymph node metastasis, and vascular invasion. Our findings revealed that the knocking-down of LOC100507144 inhibited the expression of crucial stemness factors, including CD44, Nanog, and Sox2, and accordingly resulted in suppressing their targets, miR-302 and miR-21. Our expression data represented that the expression of LOC100507144 transcript was substantially higher in tumors with advanced stages, lymph node metastasis, and vascular invasion. Yes Loss-of-function examinations demonstrated that LOC100507144 contributed to CRC cell proliferation by restricting apoptosis, cellular senescence, and promoting cell cycle. Gain-of-function experiments also confirmed these results. Our data illustrated that LOC100507144 enhanced the migration and the epithelial to mesenchymal transition (EMT) of CRC cells, accompanied by the generation of cells with stemness characteristics. 34882869 LOC100506114 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Cancer-associated fibroblasts Interaction(GDF10) Western Blot//Wound Healing Assay//CCK8//Flow Cytometry//FISH//qRT-PCR//IHC//IF Here, we first identify an uncharacterized lncRNA, LOC100506114, which is significantly upregulated in CAF and is involved in the functional transformation of normal fibroblasts (NF) and CAF. The profile of gene co-expression analysis shows that growth differentiation factor 10 (GDF10) is positively correlated with the expression of LOC100506114. CAF promote stromal fibroblast activation and the proliferation and migration of tumor cells by secreting GDF10. Yes Expression of LOC100506114 enhances the expression of fibroblast activation protein alpha and α-smooth muscle actin in NF and promotes malignant characteristics of NF and CAF in vivo and in vitro. 33657265 LOC100505851 LncRNA Homo sapiens Breast Neoplasms breast cancer and adjacent tissues Expression(lower expressed) PCR LncRNA LOC100505851 was significantly expressed at lower levels in cancer tissues than in adjacent tissues (P<0.001). Its expression was related to human epidermal growth factor receptor 2 (HER2) expression (P=0.003) and molecular subtype based on immunohistochemistry (P=0.001). LncRNA LOC100505851 was located mainly in the nucleus and was significantly downregulated in breast cancers. Its expression was related to a higher pCR rate and better RFS and OS, indicating its potential value as a novel predictive and prognostic biomarker in breast cancer. Yes LncRNA LOC100505851 was significantly expressed at lower levels in cancer tissues than in adjacent tissues (P<0.001). Its expression was related to human epidermal growth factor receptor 2 (HER2) expression (P=0.003) and molecular subtype based on immunohistochemistry (P=0.001). 34268074 LOC100505817 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues Interaction(miR-20a-reduced WT1) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Microarray//Transwell Assay The results found poor expression LOC100505817 was poorly expressed in GC cells and tissues. Wnt/β-catenin pathway and EMT in GC cells were suppressed by LOC100505817 through miR-20a-inhibted WT1. Yes Overexpressed LOC100505817 resulted in the significant reduction of cell proliferation, migration and invasion as well as the expression of Wnt2b, β-catenin, CyclinD1, N-cadherin, Vimentin and snail, while increased cell apoptosis along with the expression of E-cadherin. 34385891 LOC100132707 LncRNA Homo sapiens Uveal melanoma cell lines regulation[ LOC100132707/JAK2 axis] qRT-PCR//Transwell Assay LOC100132707 expression in metastatic UM cell line MM28 was significantly higher than that of the non-metastatic UM cell lines, MP38, MP46 and MP65, as well as the expressions of LOC100132707-related genes, including XRN1, PARP14, JAK2, DDX60, BUB1 and SAMD9L. The LOC100132707/JAK2 axis might serve as a potent target for the prevention and treatment of UM metastasis. Yes LOC100132707 downregulation significantly repressed cell migration and invasion abilities, whereas overexpressing JAK2 rescued these effects. 33364785 hsa_circ_0000228 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction(microRNA-195-5p/ lysyl oxidase-like protein 2 axis) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay In this study, we demonstrated that circ_0000228 showed a remarkable up-modulation in CC tissues and cell lines. Yes Circ_0000228 knockdown repressed the growth and metastatic potential of CC cells. Mechanistically, circ_0000228 facilitated CC progression through sponging miR-195-5p and up-modulating LOXL2 expression. 34308761 hsa_circ_0001247 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction( miR-1270) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//BrdU//Transwell Assay Compared with that in adjacent tissues and normal cervical epithelial cells, circ_0001247 expression in CC tissues and cell lines was significantly increased; circ_0001247 sponged miR-1270 in CC cells; miR-1270 diminished the promoting effect of circ_0001247 by inactivating the ZEB2. Yes knocking down circ_0001247 expression could inhibit the proliferation and metastasis of CC cells, and promote apoptosis, while circ_0001247 overexpression worked oppositely 33386495 LOXL1-AS1 LncRNA Homo sapiens Medulloblastoma medulloblastoma tissues Regulation[PI3K/AKT Pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Transwell Assay It was initially found that LOXL1-AS1 was significantly overexpressed in clinical medulloblastoma tissues compared with the adjacent noncancerous tissues. These results suggest that LncRNA LOXL1-AS1 promoted the proliferation and metastasis of medulloblastoma by activating the PI3K-AKT pathway, providing evidence that knockdown of LncRNA LOXL1-AS1 might be a potential therapeutic strategy against medulloblastoma. LOXL1-AS1 was also highly expressed in medulloblastoma at advanced stages and differentially expressed in a series of medulloblastoma cell lines. Yes Knockdown of LOXL1-AS1 using shRNAs significantly inhibited cell viability and colony formation capacities in D283 and D341 cells. 30050750 LOXL1-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction[LOXL1-AS1/miR-423-5p/MYBL2] RNA Pull-Down//ChIP//Western Blot//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our present study suggested that LOXL1-AS1 expression was considerably increased in LUAD tissues and cells.hese findings manifested the carcinogenic role of LOXL1-AS1 and LOXL1-AS1/miR-423-5p/MYBL2 feedback loop in LUAD, which could be helpful to explore effective therapeutic strategy for LUAD patients. Yes Moreover, LOXL1-AS1 deficiency notably hampered cell proliferation and migration as well as dramatically facilitated cell apoptosis. 31758653 LOXL1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[targeting miR-324-3p] CCK8//qRT-PCR The expression of LOXL1-AS1 was overexpressed in NSCLC specimens than adjacent control specimens.These results indicated that LOXL1-AS1 enhanced NSCLC cell proliferation and invasion via sponging miR-324-3p in NSCLC cell. Yes Ectopic expression of LOXL1-AS1 promoted H1299 cell and H23 cell proliferation. 31737192 LOXL1-AS1 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues Interaction[miR-324-3p ] qRT-PCR LOXL1-AS1 was found overexpressed in CCA tissues screened by high-throughput sequencing technology. Moreover, luciferase reporter and rescue assays indicated that LOXL1-AS1 functioned as a ceRNA to elevate ATP-binding cassette transporter A1 (ABCA1) level by sponging miR-324-3p and exhibited the malignant phenotypes of CCA cells, thereby playing an oncogenic role in CCA. Taken together, this study reveals that LOXL1-AS1 might act as a potential biomarker and therapeutic target for CCA clinical application. Additionally, upregulation of LOXL1-AS1 was associated with lymph node invasion, advanced TNM stages and unfavorable prognosis. Yes Loss-of-function and gain-of-function experiments were conducted and validated that LOXL1-AS1 could facilitate cell proliferation, migration and invasion and attenuate cell apoptosis. 31003776 LOXL1-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and cell lines interaction[miR-28-5p,RAP1B ] colony Formation Assay//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay LOXL1-AS1 was found markedly up-regulated in EC tissues and cell lines. In summary, LOXL1-AS1 exerted oncogenic roles in EC progression by sponging miR-28-5p and thereby upregulating RAP1B. This finding might provide potential targets for EC therapy. Yes LOXL1-AS1 knockdown displayed evident suppression in cell proliferation, migration and invasion, as well as promotion in cell apoptosis. 32006897 LOXL1-AS1 LncRNA Homo sapiens Liver Neoplasms liver cancer tissues and cells Interaction(miR-377-3p/NFIB axis) Western Blot//Wound Healing Assay//qRT-PCR//MTT//Colony Formation Assay//Bioinformatics Analysis In the present study, LOXL1-AS1 expression was significantly upregulated in liver cancer tissues and cells compared with in normal liver tissues and cells, respectively.Subsequently, LOXL1-AS1 acted as a microRNA (miR)-377-3p sponge, and nuclear factor I B (NFIB) was confirmed as the downstream target of miR-377-3p in liver cancer cells. Additionally, rescue assays suggested that NFIB overexpression countervailed the inhibitory influence of LOXL1-AS1 silencing on liver cancer cellular processes. High LOXL1-AS1 expression was associated with poor clinical outcomes in patients with liver cancer. Yes Furthermore, LOXL1-AS1-knockdown suppressed glucose metabolism, proliferation, migration and epithelial-mesenchymal transition (EMT) of liver cancer cells. 34267816 LOXL1-AS1 LncRNA Homo sapiens cervical squamous cell carcinoma CSCC tissues interaction[miR-21] Transwell Assay//qRT-PCR//Luciferase Report Assay//Western Blot We observed that LOXL1-AS1 was downregulated in CSCC.Therefore, LOXL1-AS1 may promote CSCC cell invasion and migration by sponging miR-21 to upregulate RHOB. Yes Cell invasion and migration analysis showed decreased invasion and migration rates of CSCC cells after LOXL1-AS1 and RHOB overexpression. 32881598 LOXL1-AS1 LncRNA Homo sapiens Laryngeal Neoplasms cells regulation[miR-589-5p/TRAF6 axis] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LOXL1-AS1 was overexpressed in laryngocarcinoma cells. LOXL1-AS1 promotes the proliferation and migration of laryngocarcinoma cells through absorbing miR-589-5p to upregulate TRAF6 expression. Yes Silencing of LOXL1-AS1 suppressed cell proliferation, migration and EMT in laryngocarcinoma. 33061856 LOXL1-AS1 LncRNA Homo sapiens Coronary Disease HCAEC Interaction(miR-16-5p) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//ELISA//Bioinformatics Analysis//IF LOXL1-AS1 was highly expressed in CHD patients. LOXL1-AS1 had diagnostic value for CHD and predictive value for MACE occurrence. ox-LDL-treated HCAECs showed reduced viability, increased IL-1β and IL-18 concentrations, and elevated NLPR3, cleaved-caspase-1, and GSDMD-N levels. LOXL1-AS1 silencing promoted cell viability and reduced pyroptosis. LOXL1-AS1 bound to miR-16-5p and miR-16-5p targeted SNX16. Inhibition of miR-16-5p reversed the inhibitory effect of LOXL1-AS1 silencing on HCAEC pyroptosis. LOXL1-AS1 had diagnostic value for CHD and predictive value for MACE occurrence. Yes LOXL1-AS1 silencing promoted cell viability and reduced pyroptosis. LOXL1-AS1 bound to miR-16-5p and miR-16-5p targeted SNX16. 34633594 circTICRR CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells Interaction(HuR/GLUD1 ) In Vivo Experiment//RNA Pull-Down//Northern Blot//Western Blot//CCK8//qRT-PCR//FISH//RIP//RNA-seq//Cell Apoptosis Assay Here, we identified the overexpression of circTICRR, a circular RNA, in cervical cancer. CircTICRR interacted with HuR protein via binding to F287/F289 in the RRM3 domain of HuR, stabilizing GLUD1 mRNA and elevating the level of GLUD1 protein. Yes In vitro experiments showed that knockdown of circTICRR activated autophagy, and consequently promoted apoptosis and inhibited proliferation in cervical cancer cells, and vice versa. In vivo experiments revealed that knockdown of circTICRR suppressed the growth of transplanted tumors. 35595754 hsa_circ_0011385 CircRNA Homo sapiens Uterine Cervical Neoplasms CC samples and cell lines Interaction(miR-149-5p/PRDX6 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tube Formation Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//IHC//Transwell Assay We observed that hsa_circ_0011385 and PRDX6 were up-regulated while miR-149-5p was down-regulated in CC samples and cell lines. Hsa_circ_0011385 could mediate PRDX6 expression through binding to miR-149-5p. MiR-149-5p silencing reversed hsa_circ_0011385 knockdown-mediated effects on CC cell angiogenesis and malignancy. PRDX6 overexpression overturned the inhibitory effects of miR-149-5p overexpression on angiogenesis and malignant behaviors of CC cells. In conclusion, hsa_circ_0011385 accelerated angiogenesis and malignant behaviors of CC cells by regulating the miR-149-5p/PRDX6 axis, manifesting that hsa_circ_0011385 might be a therapeutic target for CC. CC patients with high hsa_circ_0011385 expression possessed a shorter overall survival. Yes Hsa_circ_0011385 knockdown reduced tumor growth in vivo and facilitated apoptosis, cell cycle arrest, impeded proliferation, metastasis, invasion, and angiogenesis of CC cells in vitro. 35240453 LONP2 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and BC cells Interaction(microRNA-584-5p) qRT-PCR//RNA Pull-Down//Luciferase Report Assay CircLONP2 was significantly upregulated in precancerous BC tissues and BC cells. CircLONP2 depletion inhibited cell viability, proliferation, and invasion of BC cell lines, which could be partially rescued by miR-584-5p inhibitor. Further experiments indicated that miR-584-5p regulates cell viability, proliferation, and invasion via directly targeting YAP1. Yes CircLONP2 depletion inhibited cell viability, proliferation, and invasion of BC cell lines, which could be partially rescued by miR-584-5p inhibitor. Further experiments indicated that miR-584-5p regulates cell viability, proliferation, and invasion via directly targeting YAP1. 35358000 LOLA1 LncRNA Homo sapiens Leukoplakia, Oral (AKT/GSK-3β pathway) Western Blot//Transfection//Migration Assay//qRT-PCR//FISH//Cell Apoptosis Assay//Microarray//Cell Proliferation Assay//Cell Cycle Assay//Invasion Assay//Transwell Assay The results of qRT-PCR revealed that LOLA1 aberrant expression was validated in tissue samples and cell lines from the normal oral mucosa, OL to OSCC. Yes Cell function assays showed that LOLA1 significantly influenced cell migration, invasion, and epithelial-mesenchymal transition (EMT) protein expression. 33969929 hsa_circ_0087429 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells Interaction(miR-5003-3p/OGN axis) In Vivo Experiment//IHC//Western Blot//Transfection//Wound Healing Assay//Invasion Assay//Tube Formation Assay//CCK8//qRT-PCR//RIP//IF//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay circ_0087429 is significantly downregulated in cervical cancer tissues and cells and negatively correlated with International Federation of Gynecology and Obstetrics (FIGO) staging and lymphatic metastasis in cervical cancer patients.OGN is significantly downregulated in cervical cancer tissues and cells. circ_0087429 can upregulate the expression of OGN by competitively binding with miR-5003-3p, thereby reversing EMT and inhibiting the progression of cervical cancer. EIF4A3 can inhibit circ_0087429 expression by binding to its flanking regions. Yes circ_0087429 can significantly inhibit the proliferation, migration, invasion and angiogenesis of cervical cancer in vitro and tumour growth and metastasis in vivo. 35513835 hsa_circ_0005576 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction( miR-1305/PAIP1 axis) In Vivo Experiment//IHC//Western Blot//Transfection//Invasion Assay//Migration Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ_0005576 and PAIP1 were upregulated, while miR-1305 was downregulated in CC tissues and cells. Meanwhile, circ_0005576 could sponge miR-1305 to promote PAIP1 expression. Furthermore, PAIP1 overexpression relieved the influence of circ_0005576 silence on the growth of CC cells. Yes Knockdown of circ_0005576 suppressed the proliferation, migration, and invasion of CC cells, while the silence of miR-1305 facilitated the development of CC cells. Additionally, circ_0005576 silence hindered CC tumor growth in vivo. 35378711 hsa_circ_0036602 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(miR-34-5p,miR-431-5p/HMGB1) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RIP//FISH//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay Circ0036602 was upregulated in HPV-16 positive CC and correlated with a poor prognosis. Further studies showed that circ0036602 could bind to miR-34-5p and miR-431-5p to regulate the expression of the target gene HMGB1. Circ0036602 was upregulated in HPV-16 positive CC and correlated with a poor prognosis. Moreover, circ0036602 expression significantly correlated with the clinicopathologic characteristics. Yes Knockdown of circ0036602 inhibited CC cell proliferation, migration, and invasion. 35145563 hsa_circ_400029 CircRNA Homo sapiens Uterine Cervical Neoplasms CC cells and tissue Interaction(miR-1285-3p/TLN1 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//FISH//Flow Cytometry//Luciferase Report Assay//Cell Cycle Assay//Transwell Assay//EdU Staining//IF To begin with, circRNA_400029 was upregulated in CC cells and tissue. Interestingly, miR-1285-3p targeted circRNA_400029 and down-regulated of miR-1285-3p could reverse the effects of circRNA_400029 weak-expression on progression and apoptosis of CC cells. Moreover, TLN1 was up-regulated in CC cells and identified as a direct target of miR-1285-3p. Meanwhile, we found that miR-1285-3p negatively regulated the function of TLN1. Finally, the circRNA_400029/miR-1285-3p/TLN1 axis could affect tumor growth in vivo. Yes Knockdown circRNA_400029 inhibited cell proliferation, migration and invasion while induced cell apoptosis. 35069901 hsa_circ_0018289 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(miR-1294/ICMT axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//IF//Colony Formation Assay//EdU Staining//Transwell Assay Hsa_circ_0018289 was elevated in CC tissues and cells, its deficiency could repress growth, metastasis, and glycolysis of CC cells in vitro, as well as hamper tumor growth in vivo.Hsa_circ_0018289 sponged miR-1294 while miR-1294 bound with ICMT, and the inhibition of miR-1294 or addition of ICMT could partially relieve the effect caused by hsa_circ_0018289 depletion. Yes Hsa_circ_0018289 was elevated in CC tissues and cells, its deficiency could repress growth, metastasis, and glycolysis of CC cells in vitro, as well as hamper tumor growth in vivo. 35312113 circCCDC134 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction( miR-503-5p/MYB) In Vivo Experiment//RNA Pull-Down//Transfection//qRT-PCR//FISH//RIP//ChIP-seq//IHC The results revealed that circCCDC134 recruited p65 in the nucleus and acted as a miR-503-5p sponge to regulate the expression of MYB in the cytoplasm, ultimately stimulating HIF1A transcription and facilitating CC growth and metastasis. Yes The results revealed that circCCDC134 recruited p65 in the nucleus and acted as a miR-503-5p sponge to regulate the expression of MYB in the cytoplasm, ultimately stimulating HIF1A transcription and facilitating CC growth and metastasis. 36028854 LOC730100 LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[miR-760/FOXA1 axis] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the current research, we showed that LOC730100 expression was increased in glioma tissues and cell lines. In conclusion, our findings revealed that LOC730100 promoted glioma progression through regulating miR-760/FOXA1 axis. Yes Loss-of-function assays showed that LOC730100 knockdown inhibited proliferation, migration and invasion of glioma cells, but increasing apoptosis. 30914197 LOXL1-AS1 LncRNA Homo sapiens Pancreatic Neoplasms Regulation[ LOXL1-AS1/miR-28-5p/SEMA7A axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Our findings constitute the first report to delineate that lncRNA LOXL1-AS1/miR-28-5p/SEMA7A axis facilitates PC progression. According to our experimental results, we found the expression of miR-28-5p was downregulated in PC cells and miR-28-5p overexpression inhibited cell proliferation and migration in PC. LOXL1-AS1 could sponge miR-28-5p and then upregulate the expression of SEMA7A. Thus, LOXL1-AS1/miR-28-5p/SEMA7A axis facilitated PC progression. This initially proposed point might provide a novel molecular target for PC treatment. Yes Therefore, the function of LOXL1-AS1 was further explored in PC, presenting that LOXL1-AS1 suppression inhibited cell proliferation and migration. 31732974 LOXL1-AS1 LncRNA Homo sapiens Glioma glioma cells and tissues Interaction(miR-374b-5p/MMP14 axis) In Vivo Experiment//Western Blot//Transfection//Tube Formation Assay//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay In this study, low levels of TIAR and high levels of LOXL1-AS1 were found in glioma cells and tissues. In summary, we demonstrated that TIAR combined with LOXL1-AS1 modulates VM in glioma via the miR-374b-5p/MMP14 axis, revealing novel targets for glioma therapy. Yes LOXL1-AS1 acted like a miRNA sponge towards miR-374b-5p so that downregulation of the former greatly inhibited cell proliferation, migration, invasion and VM. 34890108 hsa_circ_0005358 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction(PTBP1/CDCP1) RNA Pull-Down//Northern Blot//Western Blot//ISH//Transfection//Wound Healing Assay//Migration Assay//qRT-PCR//FISH//RIP//RNA-seq//PCR//Cell Proliferation Assay//Invasion Assay In this study, we identified a downregulated circRNA derived from the host gene Gli1 (hsa_circ_0005358) in cervical cancer tissues, which was expressed at lower levels in tissues with extracervical metastasis than in those without extracervical metastasis. RNA-pull-down assay, mass spectrometry, and RNA immunoprecipitation validated the findings that hsa_circ_0005358 functions via its 215-224 sequence, which interacts with polypyrimidine tract-binding protein 1 (PTBP1). RNA-sequencing profiling revealed that CUB-domain-containing protein 1 (CDCP1) is a common target for hsa_circ_0005358 and PTBP1. Yes Upregulation of hsa_circ_0005358 significantly suppressed the migration and invasion of cervical cancer cells in vitro, and downregulation of hsa_circ_0005358 had the opposite effect. A mouse model revealed that cervical cancer cells overexpressing hsa_circ_0005358 possessed weaker metastatic potential in vivo. 34976440 LOXL1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells and tissues Interaction( LOXL1-AS1/miR-423-5p/ENC1 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//IF The results of RT-qPCR demonstrated that LOXL1-AS1 and ectodermal-neural cortex 1 (ENC1) expression levels were upregulated in CC cells and tissues, while microRNA-423-5p (miR-423-5p) level was downregulated. As subcellular fractionation assays, RNA pull down assays and luciferase reporter assays revealed, LOXL1-AS1 bound to miR-423-5p and miR-423-5p targeted ENC1. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays, wound healing and colony formation assays demonstrated that miR-423-5p upregulation and LOXL1-AS1 downregulation inhibited CC cell proliferation and migration, while ENC1 upregulation attenuated the inhibitory effects of miR-423-5p upregulation on the malignant phenotypes of CC cells. Western blotting was conducted to measure protein levels and the results showed that ENC1 knockdown inhibited the activation of ERK/MEK pathway. Yes The in vivo experiments demonstrated that LOXL1-AS1 downregulation inhibited tumor growth and metastasis and proliferation of CC cells. 35015607 hsa_circ_0000135 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells Interaction( circ_0000135/miR-140-3p/PDZK1) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Transwell Assay circ_0000135 and PDZK1 expressions were increased, while those of miR-140-3p were decreased in cervical cancer tissues and cells (both P < 0.05). circ_0000135 had conserved target of miR-140-3p. There was a direct interaction between circ_0000135 and miR-140-3p. miR-140-3p might have direct interaction with PDZK1. sh-circ_0000135 and/or miR-140-3p treatment showed obviously decreased PDZK1 expression, decreased cell activity, arrested cells in G0/G1 phase, downregulated cell migration and invasion; sh-circ_0000135 and/or miR-140-3p mimic treatment showed obviously decreased tumor volume, tumor weight, and Ki67 expression (all P < 0.05). Yes sh-circ_0000135 group had decreased cell viability, arrested cells in G0/G1 phase, decreased CyclinD1 expression, inhibited cell migration and invasion; sh-circ_0000135 group showed reduced tumor volume, weight, and lower Ki67 expression (all P < 0.05). 35066758 LOXL1‑AS1 LncRNA Homo sapiens Thymoma thymoma and thymic carcinoma tissues Interaction(miR-525-5p-HSPA9) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay LOXL1-AS1 and HSPA9 were overexpressed in thymoma and thymic carcinoma; high levels of LOXL1-AS1 and HSPA9 were associated with poor prognosis, and there was a significant positive correlation between their levels. miR‑525‑5p inhibited the expression of HSPA9 protein by targeting the 3'‑untranslated region (UTR) of HSPA9 mRNA. LOXL1‑AS1 promoted the expression of HSPA9 as a sponge targeting miR‑525‑5p. LOXL1-AS1 and HSPA9 were overexpressed in thymoma and thymic carcinoma; high levels of LOXL1-AS1 and HSPA9 were associated with poor prognosis, and there was a significant positive correlation between their levels. Downregulation of miR?525?5p expression was also associated with poor prognosis of patients. Yes Animal experiment results also showed that knockdown of miR?525?5p promoted cancer by promoting the expression of HSPA9. 33907842 LOXL1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Regulation[miR-142-5p/PIK3CA Axis] CCK8//qRT-PCR//Western Blot//Transwell Assay LOXL1-AS1 expression in GC samples was significantly increased, which was correlated with unfavorable pathological indexes.Additionally, overexpressed LOXL1-AS1 notably reduced the expression of miR-142-5p, but enhanced the expression level of PIK3CA. Highly expressed LOXL1-AS1 was closely linked to shorter overall survival time and post-progression survival time of the patients. Yes Additionally, overexpressed LOXL1-AS1 notably reduced the expression of miR-142-5p, but enhanced the expression level of PIK3CA. In vivo experiments further validated that knockdown of LOXL1-AS1 inhibited the growth and metastasis of GC cells via regulating miR-142-5p and PIK3CA. 31908498 LOXL1-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cells Interaction[miR-708-5p/USF1 pathway] RNA Pull-Down//ChIP//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay LOXL1-AS1 was highly expressed in tissues and cells of gastric cancer.Rescue experiments testified the stimulative role of LOXL1-AS1/miR-708-5p/USF1 pathway in gastric cancer progression. Yes Our findings demonstrated that LOXL1-AS1 accelerated the deterioration of gastric cancer by inducing cell proliferation, migration, EMT and stemness. 31468594 LOXL1-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer and adjacent normal tissues,cell lines(MCF42,MDA-MB-7) Interaction[Antagonizing miR-708-5p ] RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay//Transwell Assay The results showed that LOXL1-AS1 expression levels were significantly higher in breast cancer samples than those in corresponding normal tissues.Overall, LOXL1-AS1 upregulation facilitates breast cancer invasion and metastasis by blocking miR-708-5p expression and activity. Increased LOXL1-AS1 expression is correlated with tumor stage and lymph node metastasis in breast cancer patients. Yes Biologically, overexpression of LOXL1-AS1 enhances and knockdown of LOXL1-AS1 suppresses breast cancer cell migration and invasion. In vivo studies demonstrate that depletion of LOXL1-AS1 inhibits breast cancer metastasis. 31945728 LOXL1-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction[regulating miR-143-3p] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay In this study, we found that LOXL1-AS1 expression was induced while miR-142-3p expression was decreased in breast cancer tissues and cells, implying that LOXL1-AS1 and miR-143-3p play an important role in cell progression of breast cancer.The analysis of luciferase reporter assay determined that LOXL1-AS1 directly targeted miR-143-3p in breast cancer cells. The rescue experiments further proved that miR-143-3p reversed the inhibited effects of si- LOXL1-AS1 on breast cancer cells. Yes Further investigation showed that silencing LOXL1-AS1 inhibited proliferation, promoted cell apoptosis and decreased the capacity of cell migrated and invasive in breast cancer cells. 31841194 LOXL1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues and cells regulation[ miR-3128/RHOXF2 Axis] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay LncRNA LOXL1-AS1 was higher expressed in lung cancer tissues and cells.LOXL1-AS1 promotes the progression of NSCLC by regulating miR-3128/RHOXF2 axis, which might be a new potential target for the diagnosis and treatment of NSCLC. Moreover, LOXL1-AS1 expression was upregulated in tumor tissues with advanced stages and metastasis. Yes After knocking down LOXL1-AS1, proliferation, invasion and migration of H1299 and A549 cells were inhibited. 32636639 LOXL1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Regulation(DESC1) Migration Assay//CCK8//qRT-PCR//Cell Cycle Assay//Invasion Assay Here we validated that LOXL1-AS1 was significantly upregulated in ESCC tissues compared with the corresponding adjacent non-neoplastic tissues, and LOXL1-AS1 expression was positively correlated with ESCC patients' lymph node metastasis. From high throughput RNA sequencing (RNA-seq) analysis, we identified that differentially expressed in squamous cell carcinoma 1 (DESC1) was a critical downstream target of LOXL1-AS1. Here we validated that LOXL1-AS1 was significantly upregulated in ESCC tissues compared with the corresponding adjacent non-neoplastic tissues, and LOXL1-AS1 expression was positively correlated with ESCC patients' lymph node metastasis. Yes LOXL1-AS1 knockdown impaired ESCC cells proliferation, migration and invasion capabilities in vitro. Furthermore, inhibiting LOXL1-AS1 in ESCC cells increased the percentage of cells at the G1 phase, accompanied by reducing in S phase in contrast to scramble control, and silencing of LOXL1-AS1 evoked ESCC cell apoptosis. 33391449 hsa_circ_0000190 CircRNA Homo sapiens Uterine Cervical Neoplasms CC cells and tisuuses Interaction(miR-1252-5p/EIF4EBP2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0000190 functioned through the modulation of miR-1252-5p/EIF4EBP2 axis. Yes Overexpressed circ_0000190 attenuated CC progression in vitro and in vivo. 35414334 LOXL1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-708-5p/CD44-EGFR Axis] Western Blot//Wound Healing Assay//qRT-PCR//IF//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Transwell Assay This study demonstrated that lncRNA LOXL1-AS1 enhances multiplication, migration, invasion, and progression of CRC by sponging miR-708-5p to regulate the CD44-EGFR signal pathway. In this study, we reveal that the regulation of lncRNA LOXL1-AS1 occurs within CRC based on the correlation with poor clinical outcomes. Yes LOXL1-AS1 knockdown along with miR-708-5p overpresentation in CRC cell lines inhibited cell multiplication, migration, and invasion. 32821123 LOXL1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Regulation(miR-1224-5p/miR-761/HK2 Axis) Western Blot//Wound Healing Assay//qRT-PCR//Colony Formation Assay//Transwell Assay LOXL1-AS1 and HK2 levels were increased, while miR-1224-5p and miR-761 levels were reduced in CRC tissues and cells. Knockdown of LOXL1-AS1 suppressed CRC cell proliferation, invasion, migration, and glycolysis, and induced cell apoptosis. Silencing of LOXL1-AS1 blocked tumor growth in vivo. Moreover, LOXL1-AS1 accelerated CRC cell progression by absorbing miR-1224-5p/miR-761. Besides, miR-1224-5p and miR-761 inhibited CRC cell progression via targeting HK2. LOXL1-AS1 contributed to CRC progression via modulating miR-1224-5p/miR-761/HK2 pathway. Yes Knockdown of LOXL1-AS1 suppressed CRC cell proliferation, invasion, migration, and glycolysis, and induced cell apoptosis. Silencing of LOXL1-AS1 blocked tumor growth in vivo. 35441953 LOXL1-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells interaction[sponges miR-589-5p] qRT-PCR//Western Blot LOXL1-AS1 was highly expressed in RCC tissues and cells. LncRNA LOXL1-AS1 sequestered miR-589-5p to augment CBX5 expression in RCC cells, opening a new way for potential development in RCC treatment. Yes Moreover, knockdown of LOXL1-AS1 hampered RCC cell proliferation and migration. 33185692 LOXL1-AS1 LncRNA Homo sapiens Osteoarthritis OA cartilage tissues regulation[miR-423-5p/KDM5C axis] qRT-PCR LOXL1-AS1 was up-regulated in OA cartilage tissues.LncRNA LOXL1-AS1 is transcriptionally activated by JUND and facilitates the proliferation and inflammation of chondrocytes via elevating miR-423-5p-mediated KDM5C in OA, which may provide potential therapeutic target for OA. Yes Silencing LOXL1-AS1 hampered proliferation and inflammation, yet promoting apoptosis in chondrocytes. 32679142 LOXL1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(LOXL1-AS1/miR-3614-5p/YY1 signal axis) qRT-PCR We discovered that LOXL1-AS1 was high expressed in HCC cells. Inhibition of LOXL1-AS1 repressed cell proliferation, migration and invasion, but enhanced cell apoptosis in HCC. Further, miR-3614-5p was proven to be sponged by LOXL1-AS1. Additionally, Yin Yang 1 (YY1) was proven as the target gene of miR-3614-5p, and YY1 depletion could repress HCC cell malignant behaviors. YY1 could also transcriptionally activate LOXL1-AS1 expression. In rescue assays, we confirmed that overexpression of YY1 or miR-3614-5p inhibition could reverse the suppressive effects of LOXL1-AS1 silence on the malignant behaviors of HCC cells. Yes Inhibition of LOXL1-AS1 repressed cell proliferation, migration and invasion, but enhanced cell apoptosis in HCC. 34863279 hsa_circ_0119412 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical tumor tissues and cancer cells Interaction( miR-217/AGR2 pathway) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay circ_0119412 expression was highly enhanced in cervical tumor tissues and cancer cells. AGR2 was upregulated in cervical cancer by the public bioinformatics data. circ_0119412 bound to miR-217, and miR-217 bound to AGR 3'UTR. The promoting effects of circ_0119412 overexpression on cancer cell malignant phenotypes were reversed by miR-217 enrichment. In addition, increased expression of miR-217 suppressed AGR2 expression, thus weakening the functional effects of AGR2. Yes circ_0119412 overexpression aggravated cervical cancer cell proliferation, migration, and adhesion, and its overexpression was also conducive to tumor formation and growth in animal models. 35274779 LOXL1-AS1 LncRNA Homo sapiens Ovarian Neoplasms ovarian carcinoma tissue regulation[miR-18b-5p/VMA21 axis] Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay LOXL1-AS1 is significantly overexpressed in ovarian carcinoma tissue compared with adjacent non-cancerous sample.These findings suggest that lncRNA LOXL1-AS1 promotes ovarian cancer cell growth, migratory and invasiveness via modulating miR-18b-5p/VMA21 axis. Yes Transfection of LOXL1-AS1 siRNA or miR-18b-5p mimics inhibits the growth and aggressive phenotypes of SKOV3 and OVCAR3 cell. 32058209 LOXL1-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Interaction[PI3K-AKT pathway] qRT-PCR//MTT//Western Blot//Transwell Assay In our study, we found LOXL1-AS1 expression levels were higher in osteosarcoma tissues and cell lines than normal bone tissues and normal osteoblast cell line, respectively.The loss-of-function studies showed knockdown of LOXL1-AS1 dramatically inhibited osteosarcoma cell proliferation, migration, and invasion through suppressing PI3K-AKT pathway. In conclusion, LOXL1-AS1 predicts clinical progression and poor prognosis in osteosarcoma patients and functions as oncogenic lncRNA to regulate cell proliferation, cell cycle, migration, and invasion. Moreover, high-expression of LOXL1-AS1 was correlated with Enneking stage, tumor size, distant metastasis, histological grade, and overall survival time in osteosarcoma patients. Yes The loss-of-function studies showed knockdown of LOXL1-AS1 dramatically inhibited osteosarcoma cell proliferation, migration, and invasion through suppressing PI3K-AKT pathway. 30944201 LOXL1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(miR-526b-5p /LYPLA1 Axis) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Tube Formation Assay//qRT-PCR//RIP//FISH//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay In this study, LOXL1-AS1 was found elevated in CC tissues and cells. Furthermore, we found that LOXL1-AS1 upregulated Lysophospholipase 1 expression via sequestering miR‐526b-5p. Rescue assays revealed that overexpression of LYPLA1 reversed the LOXL1-AS1 silencing-induced inhibitory effects on the malignant phenotypes of CC cells. Yes LOXL1-AS1 depletion restrained CC cell proliferation, migration, invasion, and angiogenesis in vivo. 34984578 hsa_circ_0000228 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(miR-337-3p / TGFBR1 Axis) Western Blot//Transfection//BrdU//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay Circ_0000228 expression in the CC tissues and cells was up-modulated. MiR-337-3p could be adsorbed by circ_0000228. TGFBR1 was identified as a target gene of miR-337-3p that indirectly and positively modulated bycirc_0000228 in the CC cells. Yes Circ_0000228 overexpression markedly enhanced cell proliferation, migration, and invasion, while knocking down circ_0000228 remarkably repressed cell proliferation, migration, and invasion. 35279965 circRNF121 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(miR-153-3p/ATF2 axis and wnt/β-catenin pathway) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Our results showed that circRNF121 was highly expressed in CC tissues and cells. For mechanism investigation, circRNF121 could affect activating transcription factor 2 (ATF2) expression by decoying miR-153-3p, thereby accelerating CC cell development. In conclusion, circRNF121 exerted the tumor-suppressive role in CC progression by altering miR-153-3p/ATF2 axis. Yes Knockdown of circRNF121 suppressed cell growth, metastasis, epithelial-mesenchymal transition (EMT), autophagy, and wnt/β-catenin pathway in CC cells in vitro and blocked tumor formation in vivo. 34981843 hsa_circ_0072995 CircRNA Homo sapiens Uterine Cervical Neoplasms cancer tissues Interaction(miR-29a/WDR5 axis) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//IHC//Invasion Assay//IF Circ_0072995 was significantly up-regulated in cancer tissues, and its level was markedly correlated with the International Federation of Gynecology and Obstetrics system (FIGO) staging. In conclusion, circ_0072995 promoted cervical cancer development by inducing miR-29a-mediated WDR5 expression. Circ_0072995 was significantly up-regulated in cancer tissues, and its level was markedly correlated with the International Federation of Gynecology and Obstetrics system (FIGO) staging. Yes In vitro studies revealed that circ_0072995 interacts with miR-29a to induce WD repeat domain 5 (WDR5) expression and promotes the proliferation and invasion of cells, but inhibits apoptosis of cells. Knockdown of circ_0072995 or WDR5, or overexpression of miR-29a significantly inhibited tumour growth in vivo. 36168936 hsa_circ_0003221 CircRNA Homo sapiens Uterine Cervical Neoplasms cancer tissues and cells Interaction(miR-139-3p/S100A14 Pathway) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Tube Formation Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Circ_0003221 was highly expressed in cancer tissues and cells, and its downregulation suppressed cancer cell proliferation, migration, invasion, and angiogenesis and also delayed tumor growth in vivo. Circ_0003221 downregulation restrains cervical cancer cell growth, metastasis, and angiogenesis by governing the miR-139-3p/S100A14 pathway. Yes Circ_0003221 was highly expressed in cancer tissues and cells, and its downregulation suppressed cancer cell proliferation, migration, invasion, and angiogenesis and also delayed tumor growth in vivo. 35023052 hsa_circ_0000069 CircRNA Homo sapiens Uterine Cervical Neoplasms CC cells and tissues Interaction(miR-4426) In Vivo Experiment//IHC//MeRIP//Wound Healing Assay//CCK8//qRT-PCR//IF//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay We found that circ0000069 was upregulated in CC cells and tissues, and that N6-methyladenosine (m6A) modification maintained circ0000069 stability. miR-4426 specifically binds circ0000069 and mediates its functions in CC development. Yes Gain- and loss-of-function assays revealed that circ0000069 promoted CC cell proliferation and migration. 33725572 LOC644135 LncRNA Homo sapiens Leukemia, Myeloid, Acute CD8+ T cell Expression(highly expressed) Bioinformatics Analysis Pan-cancer analysis indicated that LOC644135 was most highly expressed in AML across 33 types of cancer. Patients with high expression of LOC644135 had poor overall prognosis in both TCGA-AML cohort and the TARGET-AML cohort. Especially, high expression of LOC644135 indicated inferior overall survival and event-free survival in CN-AML patients in the TCGA-AML cohort. Besides, CN-AML patients had higher expression of LOC644135 than normal samples. Multivariable analysis suggested that LOC644135 was an independent prognostic factor in AML. GSEA analysis showed that LOC644135 was associated with some immune-related pathways. Besides, high expression of LOC644135 was associated with less infiltration of CD8+ T cell. Patients with high expression of LOC644135 had poor overall prognosis in both TCGA-AML cohort and the TARGET-AML cohort. Yes Multivariable analysis suggested that LOC644135 was an independent prognostic factor in AML. GSEA analysis showed that LOC644135 was associated with some immune-related pathways. Besides, high expression of LOC644135 was associated with less infiltration of CD8+ T cell. 35713000 circCCDC66 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tumor tissues Interaction(miR-452-5p/REXO1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay The expression of circ-CCDC66 was upregulated in cervical cancer tumor tissues in comparison with normal tissues, and correlated with later tumor stage and larger tumor size.Circ-CCDC66 was an efficient molecular sponge for miR-452-5p, and negatively regulated miR-452-5p expression. MiR-452-5p directly targeted to REXO1. Circ-CCDC66 regulated REXO1 expression to modulate cervical cancer progression via miR-452-5p. Yes Downregulated circ-CCDC66 inhibited cervical cancer cell proliferation, migration, and invasion. Moreover, downregulated circ-CCDC66 was found to suppress tumor growth in vivo. 33407514 hsa_circ_0000326 CircRNA Homo sapiens Uterine Cervical Neoplasms Cervical cancer cells and tissues Interaction(microRNA-338-3p/CDK4) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Colony Formation Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Microarray//IHC//EdU Staining//Transwell Assay Cervical cancer cells and tissues were also observed to have elevated levels of circ_0000326 and the upregulation of circ_0000326 depended on the stage of cancer. Interestingly, we confirmed that circ_0000326 served as a sponge for microRNA-338-3p and that the miRNA bound to Cyclin-dependent kinase 4. In the presence of microRNA-338-3p mimic or silencing of circ_0000326, Cyclin-dependent kinase 4 expression was decreased. Yes . Transfection with siRNA of circ_0000326 resulted in the inhibition of proliferation, migration and cell cycle of cancer cells. 33735107 hsa_circ_0019435 CircRNA Homo sapiens Uterine Cervical Neoplasms CC cells Regulation(DKK1 and PTEN) ChIP//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The present study uncovered that circ_0019435 was upregulated in CC cells by qRT-PCR. Furthermore, it was disclosed that circ_0019435 binds to EZH2 to silence DKK1 and PTEN. Finally, rescue assays corroborated that DKK1 and PTEN were involved in circ_0019435-mediated CC cell progression. Yes Then, it was unveiled by a series of functional assays including colony formation, trypan blue staining, and transwell invasion assays in that circ_0019435 ablation induced the suppression of proliferation, invasion, and EMT of HeLa and SiHa cells. 34037956 LOC550643 LncRNA Homo sapiens Breast Neoplasms cell lines and 36 breast cancer tissues Interaction(miR-125b-2-3p) qRT-PCR//Luciferase Report Assay Among the cell lines, a novel lncRNA, LOC550643, was highly expressed in breast cancer cells.Furthermore, LOC550643 could inhibit miR-125b-2-3p expression to promote breast cancer cell growth and invasiveness. Furthermore, the high expression of LOC550643 was significantly correlated with the poor prognosis of breast cancer patients, especially those with triple-negative breast cancer. Yes Knockdown of LOC550643 inhibited cell proliferation of breast cancer cells by blocking cell cycle progression at S phase. LOC550643 promoted important in vitro metastatic traits such as cell migration and invasion. In addition, by using a xenograft mouse model, we demonstrated that depletion of LOC550643 suppressed the lung metastatic potential of breast cancer cells. 34354991 LOC550643 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue and cells Interaction( miR-29b-2-5p) qRT-PCR//Colony Formation Assay//Western Blot In this study, we assessed the clinical impacts of LOC550643 on CRC through the analysis of The Cancer Genome Atlas database, which revealed the significant upregulation of LOC550643 in CRC. Furthermore, miR-29b-2-5p interacted with the LOC550643 sequence. Ectopic miR-29b-2-5p significantly suppressed colon cancer cell growth and motility and induced cell apoptosis. Moreover, the high expression of LOC550643 was associated with poor survival in patients with CRC (p = 0.001). Multivariate Cox regression analysis indicated that LOC550643 overexpression was an independent prognostic factor for shorter overall survival in patients with CRC (adjusted hazard ratio, 1.90; 95% confidence interval, 1.21-3.00; p = 0.006). Yes A biological function analysis revealed that LOC550643 knockdown reduced colon cancer cell growth by hindering cell cycle progression. In addition, LOC550643 knockdown significantly induced cell apoptosis through the inhibition of signaling activity in phosphoinositide 3-kinases. Moreover, LOC550643 knockdown contributed to the inhibition of migration and invasion ability in colon cancer cells. F 35406629 hsa_circ_0001400 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction(miR-326-Akt network) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//circRNA-seq//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//Colony Formation Assay//Bioinformatics Analysis In the present study, we showed that hsa_circRNA_0001400 was highly expressed in cervical cancer tissues relative to in matched normal tissue. We showed that hsa_circRNA_0001400_siRNA can inhibit the protein expression of Akt and that the inhibition of miR-326 could rescue the inhibition of Akt in cervical cancer cells. Yes We found that hsa_circRNA_0001400_siRNA significantly promoted the apoptosis of cervical cancer cells and arrested the cell cycle and migration of cervical cancer cells. 34976014 LOC441461 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Regulation(TRAIL/RUNX1) Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Invasion Assay LOC441461 expression was lower in stage IV than in stages I, II, and III. LOC441461 downregulation increased the epithelial-to-mesenchymal transition, as indicated by increased TRAIL signaling and decreased RUNX1 interactions. The interaction of the transcription factors RELA, IRF1, ESR1, AR, POU5F1, TRIM28, and GATA1 with LOC441461 affected the degree of the malignancy of gastric cancer by modulating gene transcription. Yes The depletion of LOC441461 promoted cell proliferation, cell cycle progression, apoptosis, cell motility, and invasiveness. 35267457 LOC441461 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[RhoA/ROCK signaling] qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Western Blot This study determined that LOC441461 expression was significantly higher in CRC tissues than in adjacent normal mucosa. Overall, LOC441461 was discovered to play an oncogenic role in CRC cell growth and motility through RhoA/ROCK signaling. Yes Knockdown of the LOC441461 expression significantly suppressed colon cancer cell growth by impairing cell cycle progression and inducing cell apoptosis. 33126743 hsa_circ_0000520 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction(miR-1296) In Vivo Experiment//Western Blot//Transfection//EdU Staining//Colony Formation Assay//CCK8//qRT-PCR//FISH//RIP//Flow Cytometry//Luciferase Report Assay//IHC//Bioinformatics Analysis Hsa_circ_0000520 and cyclin-dependent kinase 2 (CDK2) were highly expressed in cervical cancer tissues.Binding sites between microRNA-1296 (miR-1296) and hsa_circ_0000520 or CDK2 were verified. Antibody to Argonaute 2 (Ago2) could precipitate hsa_circ_0000520, indicating that hsa_circ_0000520 could competitively bind to miR-1296 via Ago2. Yes Silencing hsa_circ_0000520 inhibited cervical cancer cell proliferation and promoted the inhibitory effects of miR-1296 on CDK2, thereby blocking cell cycle progression and promoting apoptosis. 34284793 LOC441178 LncRNA Homo sapiens esophageal carcinoma ESCC cells regulation[LOC441178/miR-182 axis] Flow Cytometry//qRT-PCR//Wound Healing Assay//Transwell Assay In this study, we found that LOC441178 negatively regulated miR-182 expression in ESCC cells.These data indicated that the LOC441178/miR-182 axis might represent a novel therapeutic option for the treatment of ESCC. Yes In addition, overexpression of LOC441178 inhibited the proliferation and migration and induced apoptosis in ESCC cells via downregulation of miR-182. 33173314 LOC441178 LncRNA Homo sapiens esophageal carcinoma Regulation In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//ELISA//Transwell Assay The results revealed that LOC441178 overexpression notably suppressed the metastasis of EC cells. Exosomal LOC441178 also suppressed macrophage M2 polarization, and the polarized macrophages decreased EC cell invasion. Exosomes containing LOC441178 notably inhibited the growth of EC in mice. Yes The results revealed that LOC441178 overexpression notably suppressed the metastasis of EC cells. Exosomal LOC441178 also suppressed macrophage M2 polarization, and the polarized macrophages decreased EC cell invasion. Exosomes containing LOC441178 notably inhibited the growth of EC in mice. 36250676 hsa_circ_0043280 CircRNA Homo sapiens Uterine Cervical Neoplasms CCa tissues Interaction(miR-203a-3p/PAQR3 axis) In Vivo Experiment//Western Blot//ISH//Transfection//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//migration assay//RNA-seq//H&E Staining//Luciferase Report Assay//IHC//EdU Staining Herein, we demonstrated that a circRNA derived from the TADA2A gene (hsa_circ_0043280) was significantly downregulated in CCa and that this reduction in expression was correlated with a poor prognosis. Mechanistically, hsa_circ_0043280 competitively sponges miR-203a-3p and prevents miR-203a-3p from reducing the levels of PAQR3. Yes Furthermore, our results demonstrated that hsa_circ_0043280 functions as a tumor suppressor to inhibit tumor growth and metastasis in CCa. 34588429 hsa_circ_000543 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(miR-567/ZNF268 Axis) Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Invasion Assay Hsa_circ_000543 was over-expressed in CC tissues and cells. Hsa_circ_000543 directly targeted miR-567/ZNF268 in CC cell lines. In CC tumor tissues and cells, the hsa_circ_000543 expression was negatively correlated with miR-567 expression and showed a positive correlation with ZNF268 expression. The high expression of hsa_circ_000543 indicated poor prognosis of CC patients. Yes Hsa_circ_000543 promoted cell proliferation, colony formation, migration and invasion, as well as inhibited cell apoptosis in CC cells. 34234564 circEPSTI1 CircRNA Homo sapiens Uterine Cervical Neoplasms cell lines Interaction(miR-375/409-3P/515-5p-SLC7A11 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay In this study, circEPSTI1 (hsa_circRNA_000479) was significantly upregulated in cervical cancer. circEPSTI1-miR-375/409-3P/515-5p-SLC7A11 axis affected the proliferation of cervical cancer via the competing endogenous RNAs (ceRNA) mechanism and was relative to ferroptosis. Yes Then, we observed the impact of circEPSTI1 expression on the proliferation of cervical cancer by loss-of-function assays both in vivo and vitro. 33534779 LOC440173 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells regulation[miR-30d-5p/HDAC9 axis ] qRT-PCR The expression level of LOC440173 was significantly increased in ESCC tissues and esophageal carcinoma cells.In conclusion, LOC440173 exerts a promotive role in ESCC tumorigenesis by targeting the miR-30d-5p/HDAC9 axis and regulating the EMT process. High LOC440173 expression was correlated with histological grade, tumor invasion depth, lymph node metastasis, and TNM stage. Yes Overexpression of LOC440173 promoted esophageal cancer cell proliferation, migration, and invasion, as well as the epithelial-mesenchymal transition (EMT) process in vitro, and facilitated tumor growth in vivo. 33079409 circZNF609C CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction(miR-197-3p/E2F6 axis) In Vivo Experiment//Transfection//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis//Transwell Assay In the present study, it was found that circ-ZNF609 was elevated in CC tissues and cell lines, circ-ZNF609 was identified to negatively regulate miR-197-3p expression in CC cells. Additionally, we further demonstrated that circ-ZNF609 upregulated E2F6 by interacting with miR-197-3p. Yes circ-ZNF609 deletion repressed cell viability, migration and invasion in CC. 33734009 LOC645166 LncRNA Homo sapiens Atherosclerosis T cells Regulation(Decreasingly Blocking Recruitment of the IKK Complex to K63-Linked Polyubiquitin Chains) RNA Pull-Down//Western Blot//Co-IP//qRT-PCR//Microarray we have identified that the levels of lncRNA, LOC645166, in T cells of AS patients were reduced. Overexpression of LOC645166 in Jurkat cells down-regulated the IL-23p19 expression and suppressed the JAK2/STAT3 signaling in response to stimulation by phorbol 12-myristate 13-acetate. Suppression of STAT3 activation by LOC645166 was also observed when Jurkat cells or T cells of AS patient were treated with anti-CD3/CD28 antibodies. In order to explore the role of LOC645166 in the pathogenesis of AS, RNA pull-down assay plus proteomic approach and western blotting were performed and identified that LOC645166 prefers binding the K63-linked polyubiquitin chains. LOC645166 can suppress recruitment of the IKK complex to K63-linked polyubiquitin chains and diminish IKK2 activation, leading to down-regulation of NF-κB activation. Down-regulation of LOC645166 expression in T cells of AS patients up-regulates NF-kB activation via decreasingly impeding recruitment of the IKK complex to K63-linked polyubiquitin chains, allowing AS patients to exhibit more sensitivity to stimulation by the proinflammatory cytokines or by TLR ligands. Yes Overexpression of LOC645166 in Jurkat cells down-regulated the IL-23p19 expression and suppressed the JAK2/STAT3 signaling in response to stimulation by phorbol 12-myristate 13-acetate. 33717069 circFAT1 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Interaction(miR-409-3p/CDK8 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircFAT1 was highly expressed in CC, and closely associated with poor prognosis.Mechanistic analysis showed that circFAT1 directly sponged miR-409-3p and then relieved the repressive effect of miR-409-3p on its target CDK8. CircFAT1 promoted CC progression via activating ERK1/2 and p38 MAPK pathway through the miR-409-3p/CDK8 axis, suggesting a promising prognostic biomarker and therapeutic target for CC. CircFAT1 was highly expressed in CC, and closely associated with poor prognosis. Yes CircFAT1 knockdown resulted in the suppression of proliferation, migration and invasion, and promotion of apoptosis in CC cells via the inactivation of ERK1/2 and p38 MAPK pathway; also, circFAT1 silencing could inactivate this pathway and repressed CC tumor growth in vivo. 33818788 hsa_circ_0000730 CircRNA Homo sapiens Uterine Cervical Neoplasms 50 CC patients and CC cell lines Interaction(miR-942-5p/PTEN axis) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//BrdU//Transwell Assay Circ_0000730 was significantly down-regulated in the cancer tissues of 50 CC patients and CC cell lines. Mechanistically, miR-942-5p was identified as a downstream target of circ_0000730, and circ_0000730 could positively regulate PTEN expression via repressing miR-942-5p in CC cells.Circ_0000730 inhibits the proliferation, migration, and invasion of CC cells via regulating miR-942-5p/PTEN axis. Additionally, underexpression of circ_0000730 was associated with the shorter survival time of CC patients. Yes Gain- and loss-of-function assays highlighted that circ_0000730 significantly inhibited the proliferation, migration, and invasion of CC cells. 34562344 circTPCN CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cells Regulation(circTPCN/miR-634/mTOR regulatory pathway) Transfection//Wound Healing Assay//qRT-PCR//Cell Apoptosis Assay//Microarray//Cell Proliferation Assay//Invasion Assay//Transwell Assay The expression patterns, obtained using a microarray assay, revealed a total of 192 differentially expressed circRNAs, of which 106 were upregulated and 86 were downregulated, in cervical cancer samples compared with normal cervical samples. The differential expression of circRNAs was validated using quantitative real-time polymerase chain reaction. Two circRNAs (circTPCN and circFAM185A) were confirmed to be significantly upregulated in cervical cancer samples, indicating that they represent potential biomarkers of cervical cancer. The role and the potential molecular mechanism of circTPCN in cervical cancer tumorigenesis were further investigated. Knockdown of circTPCN significantly suppressed proliferation, migration, and invasion and increased apoptosis of cervical cancer cells in vitro. Molecular analysis revealed that circTPCN acted as a sponge of miR-634 to enhance mTOR expression. Thus, the circTPCN/miR-634/mTOR regulatory pathway might be involved in cervical cancer tumorigenesis, and circTPCN is a potential therapeutic target in cervical cancer. Yes Knockdown of circTPCN significantly suppressed proliferation, migration, and invasion and increased apoptosis of cervical cancer cells in vitro 34029698 hsa_circ_0000263 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tumor tissues Interaction(miR-1179/ABL2 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining Circ_0000263 was highly expressed in CC tumor tissues. Circ_0000263 served as a sponge for miR-1179, and miR-1179 inhibitor reversed the regulation of si-circ_0000263 on CC cell proliferation and apoptosis. ABL2 could be targeted by miR-1179, and circ_0000263 could sponge miR-1179 to regulate ABL2. Overexpression of ABL2 reversed the anti-proliferation and pro-apoptosis roles of miR-1179 in CC cells. In addition, circ_0000263 knockdown reduced CC tumor growth by miR-1179/ABL2 axis. Yes Silencing of circ_0000263 suppressed CC cell proliferation and increased apoptosis. 35355231 circCDK17 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues or cells Interaction( miR-1294/YWHAZ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay CircCDK17 expression and the mRNA and protein expression levels of YWHAZ were dramatically upregulated, while miR-1294 expression was obviously downregulated in CC tissues or cells compared with control groups. Additionally, circCDK17 was a sponge of miR-1294 and miR-1294 bound to YWHAZ. Yes CircCDK17 silencing suppressed cell proliferation, migration, invasion and glycolysis, and induced cell apoptosis in CC; however, miR-1294 inhibitor restrained these effects.Furthermore, circCDK17 knockdown inhibited tumor formation in vivo. 35168653 hsa_circ_0001627 CircRNA Homo sapiens Uterine Cervical Neoplasms CC cancerous tissues and cells Interaction(miR-1225-5p/FNDC3B/PI3K/mTOR axis ) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Analyzing circRNA microarray dataset (GSE102686) and clinical specimens, a novel circRNA termed hsa_circ_0001627, was identified and it was highly expressed in CC cancerous tissues and cells, and was associated with poor clinical outcomes. Mechanistically, hsa_circ_0001627 acted as a miR-1225-5p sponge, thus indirectly regulating FNDC3B and leading to the activation of PI3K/mTOR signaling pathway. Analyzing circRNA microarray dataset (GSE102686) and clinical specimens, a novel circRNA termed hsa_circ_0001627, was identified and it was highly expressed in CC cancerous tissues and cells, and was associated with poor clinical outcomes. Yes Functionally, hsa_circ_0001627 silencing impaired the malignant progression of CC cells and the growth of CC xenografts in nude mice. 36357650 hsa_circ_0000212 CircRNA Homo sapiens Uterine Cervical Neoplasms ervical cancer tissues Interaction(miR-625-5p/PTP4A1) In Vivo Experiment//Western Blot//Transfection//Tube Formation Assay//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//IHC//Invasion Assay Circ_0000212 and PTP4A1 were highly expressed and miR-625-5p expression level was decreased in cervical cancer. MiR-625-5p was targeted by circ_0000212, and miR-625-5p inhibition reversed the effects of circ_0000212 knockdown. MiR-625-5p directly targeted PTP4A1, and the inhibitory effect of miR-625-5p on the malignant progression of cervical cancer was reversed after PTP4A1 overexpression. Yes Circ_0000212 silencing suppressed cervical cancer cell proliferation, migration, invasion and angiogenesis while promoting apoptosis. In-vivo assays validated that circ_0000212 promoted cervical cancer tumor growth in vivo . 36729102 hsa_circ_0000285 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tumor tissues Interaction(miR-654-3p/) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay The expression levels of circRNA_0000285 and miR-654-3p were analyzed in CC and the corresponding normal tissues, as well as in SiHa, HeLa, and NC104 cells using reverse transcription-quantitative polymerase chain reaction (RT-qPCR).. The results verified that miR-654-3p directly targeted circRNA_0000285 expression. circRNA_0000285 was overexpressed and miR-654-3p expression was downregulated in CC tissues and cells compared to that in control. Yes In addition, the effect of circRNA_0000285 inhibition on cell viability, apoptosis, and the expression of apoptosis-related markers was assessed using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), flow cytometry, and Western blotting assays, respectively. 35166172 hsa_circ_0001823 CircRNA Homo sapiens Uterine Cervical Neoplasms CC cells and tissues. Interaction(microRNA-613/RAB8A axis) RNA Pull-Down//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay The circ_0001823 and RAB8A expressions were increased, and miR-613 were decreased in the CC cells and tissues. Knockdown of circ_0001823 inhibited the malignant behavior of the CC cells, which was antagonized by miR-613 inhibitor. Over-expressed RAB8A reversed the miR-613 effects in the CC cells. Knockdown of circ_0001823 inhibited the malignant behaviors of the CC cells via regulating the miR-613/RAB8A axis. Yes Knockdown of circ_0001823 inhibited the malignant behavior of the CC cells, which was antagonized by miR-613 inhibitor. Over-expressed RAB8A reversed the miR-613 effects in the CC cells. Knockdown of circ_0001823 inhibited the malignant behaviors of the CC cells via regulating the miR-613/RAB8A axis. 35435110 circLMO1 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction(miR-4291/ACSL4) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The level of circLMO1 was down-regulated in cervical cancer tissues and was associated with the International Federation of Gynecology and Obstetrics (FIGO) staging.Mechanistically, circLMO1 acted as a competing endogenous RNA (ceRNA) by sponging miR-4192 to repress target gene ACSL4. CircLMO1 promoted cervical cancer cell ferroptosis through up-regulating ACSL4 expression. Overexpression of miR-4291 or knockdown of ACSL4 reversed the effect of circLMO1 on facilitating ferroptosis and repressing cervical cancer cell proliferation and invasion. Yes Functionally, circLMO1 overexpression inhibited cervical cancer growth and metastasis both in vitro and in vivo, whereas circLMO1 depletion promoted cervical cancer cell proliferation and invasion. 35321435 hsa_circ_0107593 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and CC cell lines Interaction(hsa-miR-20a-5p/93-5p/106b-5p) Bioinformatics Analysis//Transfection//Wound Healing Assay//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The results revealed that hsa_circ_0107593 has low expression in CC tissues and CC cell lines. Mechanistically, hsa_circ_0107593 serves as a sponge of hsa-miR-20a-5p, hsa-miR-93-5p, and hsa-miR-106b-5p. Collectively, our study implies that hsa_circ_0107593 has tumor-suppressing activity in CC by physically binding with hsa-miR-20a-5p, hsa-miR-93-5p, and hsa-miR-106b-5p. Moreover, negative correlations of hsa_circ_0107593 expression were found against tumor diameter, FIGO stage, and myometrial invasion. Yes Also, hsa_circ_0107593 impedes CC cell proliferation, migration, and invasion. 33585208 hsa_circ_0018289 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells Interaction(miR-183-5p/TMED5 regulatory network) In Vivo Experiment//Western Blot//Transfection//Tube Formation Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis Circ_0018289 was overexpressed in cervical cancer tissues and cells. Mechanistically, circ_0018289 targeted and regulated miR-183-5p by binding to miR-183-5p, and circ_0018289 regulated cervical cancer development and angiogenesis partially through miR-183-5p. Yes Circ_0018289 silencing impeded cell proliferation, enhanced cell apoptosis, and suppressed angiogenesis in vitro, as well as diminished tumor growth in vivo. 34404391 hsa_circ_0000511 CircRNA Homo sapiens Uterine Cervical Neoplasms cell lines Interaction(hsa-mir-296-5p/HMGA1) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//IHC//Transwell Assay hsa_circ_0000511 had the highest expression in SiHa and HeLa cells, and the expression in the cytoplasm was significantly higher than that in the nucleus, and its expression was not affected by RNase R. Our results indicate that the upregulated hsa_circ_0000511 can inhibit the proliferation, invasion, and migration of SiHa and HeLa cells by regulating hsa-mir-296-5p/HMGA1, suggesting that the hsa_circ_0000511/hsa-mir-296-5p/HMGA1 pathway may be a potential target for the treatment of cervical cancer. Yes When hsa_circ_0000511 was silenced, its expression in SiHa and HeLa cells was significantly decreased; the proliferation, invasion, and migration abilities of the two kinds of cells were significantly enhanced; and the protein expression of E-cadherin was significantly upregulated, while the protein expression of N-cadherin was significantly downregulated. 34136582 LOC648987 LncRNA Homo sapiens Carcinoma, Renal Cell 50 primary renal cell carcinoma samples and corresponding adjacent tissues Expression [highly expressed] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The RT-PCR results showed that the lncRNA LOC648987 levels were highly expressed in RCC as compared to in the adjacent tissues. Yes The results showed that the knockdown of LOC648987 inhibited the proliferation of ACHN and 786-O cells and colony formation. The knockdown of LOC648987 significantly inhibited the progression of ACHN and 786-O cells from G0/G1 to S phase and promoted cell apoptosis. Finally, the promotion of LOC648987 on RCC tumorigenesis was evaluated in BALb/c nude mice. 33858283 circSAMD11 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(miR-503/SOX4 axis ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay CircSAMD11 and SOX4 levels were elevated, while miR-503 level was reduced in CC tissues and cells. CircSAMD11 was localised in cytoplasm and directly targeted miR-503. Also, circSAMD11 sponged miR-503 to modulate SOX4 expression. Yes Knockdown of circSAMD11 suppressed CC cell proliferation, migration and invasion and accelerated apoptosis. 34546569 circACACA CircRNA Homo sapiens Uterine Cervical Neoplasms CC cells Interaction(miR-582-5p/ERO1A signaling axis) Western Blot//Transfection//Wound Healing Assay//Tunel//qRT-PCR//MTT//Luciferase Report Assay//cell invasion assay//Colony Formation Assay The results revealed that circ-ACACA expression was significantly upregulated in CC cells and silencing of circ-ACACA significantly reduced the proliferation, invasion and migration, and promoted the apoptosis of CC cells. The results suggested that circ-ACACA may promote CC tumorigenesis and glycolysis by targeting the miR-582-5p/ERO1A signaling axis. Yes The results revealed that circ-ACACA expression was significantly upregulated in CC cells and silencing of circ-ACACA significantly reduced the proliferation, invasion and migration, and promoted the apoptosis of CC cells. Knockdown of circ-ACACA markedly inhibited glycolysis in CC cells. 34584570 hsa_circ_0101119 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(EIF4A3/TCEAL6 ) RNA Pull-Down//Western Blot//Bioinformatics Analysis//Transfection//Flow Cytometry//RIP//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay It was found that hsa_circ_0101119 was highly expressed in CC tissues and cells, while TCEAL6 was lowly expressed. It was also demonstrated that hsa_circ_0101119 could recruit EIF4A3 to inhibit TCEAL6 expression in CC. Furthermore, knockdown of TCEAL6 could reverse the effects of silencing hsa_circ_0101119 on the proliferation, apoptosis, migration and invasion of HeLa cells. Yes Knockdown of hsa_circ_0101119 or TCEAL6 overexpression significantly inhibited the proliferation, migration and invasion of SiHa and HeLa cells, but facilitated apoptosis. 34278492 hsa_circ_0009035 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(miR-889-3p/HOXB7 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//Survival Analysis//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay We found that hsa_circ_0009035 was highly expressed in CC tissues and cells, and it was associated with the radioresistance of CC patients.Mechanistically, hsa_circ_0009035 directly targeted miR-889-3p by binding to miR-889-3p, and hsa_circ_0009035 modulated HOXB7 expression through miR-889-3p. HOXB7 was a functional target of miR-889-3p in regulating CC progression and radioresistance in vitro, and hsa_circ_0009035 modulated CC progression and radioresistance in vitro by miR-889-3p. Yes Moreover, the silencing of hsa_circ_0009035 inhibited CC cell proliferation, migration, invasion, and it enhanced apoptosis and radiosensitivity in vitro and weakened tumor growth in vivo. 33782039 circE2F3 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction(miR-296-5p/STAT3 ) In Vivo Experiment//Northern Blot//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//IHC//Transwell Assay Circ-E2F3 was upregulated in both CC tissues and cell lines, and this correlated with the clinicopathological features and poor prognosis of CC patients. . It was also observed that circ-E2F3 promoted the nuclear translocation of STAT3 through inhibition of miR-296-5p, thus affecting the expression of cyclin D1. Circ-E2F3 was upregulated in both CC tissues and cell lines, and this correlated with the clinicopathological features and poor prognosis of CC patients. Yes Moreover, circ-E2F3 promoted the proliferation, invasion, and migration of CC cells and tumor growth in vivo. 34468993 hsa_circ_0003221 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells Interaction(miR-758-3p/CPEB4 Axis) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ_0003221 was upregulated in cervical cancer tissues and cells. MiR-758-3p was a direct target of circ_0003221, and miR-758-3p inhibition reversed the effects of circ_0003221 knockdown in cervical cancer cells. Moreover, CPEB4 was identified as a direct target of miR-758-3p, and miR-758-3p exerted its anti-cancer role by targeting CPEB4. Yes Knockdown of circ_0003221 suppressed cell proliferation, migration, invasion, and EMT and induced cell cycle arrest in cervical cancer cells. 34262342 lncR-SMAL LncRNA Homo sapiens Cardiac Mitophagy serum of human at an age of 60, mice Regulation(Parkin protein ) Western Blot//Co-IP//Flow Cytometry//RIP//FISH//qRT-PCR//IF The heart-enriched lncR-SMAL reached the expression crest in the serum of human at an age of 60. Exogenously overexpression of lncRNA SMAL deteriorated cardiac function exactly as natural ageing and inhibited the associated cardiomyocytes mitophagy by depressing Parkin protein level.Besides, we found the interaction between lncR-SMAL and Parkin protein through computational docking analysis, pull-down and RIP assay. This would contribute to the promotive effect of lncR-SMAL on Parkin ubiquitination and decrease Parkin protein stability. Yes Improved heart ageing and mitophagy caused by Parkin overexpression were reversed by lncR-SMAL in mice. In contrast, the loss of lncR-SMAL in AC16 cells induced the upregulation of Parkin protein and ameliorated mitophagy and mitochondrial dysfunction, resulting in alleviated cardiac senescence. 35758595 lncROR LncRNA Homo sapiens Colorectal Neoplasms colorectal cancers tissues interaction[miR-223-3p] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay In the present study, Lnc-ROR was highly expressed in colorectal cancers compared with adjacent non-cancerous normal tissues. The findings of this study first revealed that ROR was upregulated in colorectal cancer cells and can promote cell proliferation and invasion by inhibiting tumor suppressor gene NF2 through interacting with miR-223-3p. Yes CCK8 assay and invasion assay suggested that ROR can promote cell proliferation and invasion. 32196591 LINC02932 LncRNA Homo sapiens Unexplained Recurrent Spontaneous Abortion lymphocytes and monocytes of human peripheral blood Interaction(HNRNPH3/HSP70) RNA Pull-Down//Western Blot//qRT-PCR//RIP//RNA-seq//Microarray//ELISA RP11-115N4.1 was identified as the most differentially expressed lncRNA which was highly upregulated in peripheral blood of non-pregnant URSA patients (P = 3.63E-07, Fold change = 2.96), and this dysregulation was further validated in approximately 26.67% additional patients (4/15). Our results demonstrated that the activation of RP11-115N4.1 can significantly increase the protein level of HSP70 via binding to HNRNPH3, which may modulate the immune responses and related to URSA. Yes RP11-115N4.1 expression was detected in both lymphocytes and monocytes of human peripheral blood, and in vitro overexpression of RP11-115N4.1 decreased cell proliferation in K562 cells significantly. 34484222 lnc34977 LncRNA Homo sapiens Mammary Neoplasms, Animal CMTs Expression(lower expressed) In Vivo Experiment//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Colony Formation Assay//Bioinformatics Analysis lnc40589 was significantly upregulated and lnc34977 was significantly downregulated in CMTs. Yes In addition, lnc40589 inhibits cell proliferation, migration and invasion, while lnc34977 promotes cell proliferation, migration and invasion. In addition, lnc34977 promotes the development of mammary tumors in animals. 35202335 Lnc00152 LncRNA Homo sapiens Retinoblastoma retinoblastoma tumour tissues regulation[miR-30d/SOX9/ZEB2 pathway] RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that Lnc00152 was significantly up-regulated in retinoblastoma tumour tissues, and was a risk factor for tumour invasion, metastasis and recurrence. Yes Lnc00152 overexpressing retinoblastoma cells exhibited a tendency to transform into mesenchymal cells, with significantly increased migration and invasion capacities, significantly decreased E-cadherin expression levels, and significantly increased N-cadherin, SOX9 and ZEB2 expression levels. 32488851 LNC_AL139002.1 LncRNA Homo sapiens Stomach Neoplasms GC cell lines (MKN-45, AGS, BGC823, SGC7901, MGC803, MKN-74) Interaction(miR-490-3p/HAVCR1 axis) Western Blot//Bioinformatics Analysis//Migration Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay The results showed that lncRNA AL139002.1 was highly expressed in GC cells. Functional examining indicated that lncRNA AL139002.1 regulated HAVCR1 expression by competitively binding miR-490-3p. In addition, lncRNA AL139002.1/miR-490-3p/HAVCR1 regulated EMT and metastasis through MEK/ERK signaling. Yes lncRNA AL139002.1 knockdown induced apoptosis, while suppressed cell proliferation, migration, invasion, and EMT. 34002670 LNC_691 LncRNA Homo sapiens Osteosarcoma osteosarcoma cell lines and tissues regulation[PTEN/PI3K/AKT signal pathway] Flow Cytometry//qRT-PCR//Colony Formation Assay In our study, we disclosed that lncRNA 691 had low expression levels in osteosarcoma cell lines and tissues.LncRNA 691/miR-9-5p could regulate the tumorigenesis by regulating the PTEN/PI3K/AKT signal pathway in osteosarcoma. Yes Overexpression of lncRNA 691 could suppress the cell proliferation and induce cell apoptosis in MG-63 cell line. 32547090 LNC_554 LncRNA Homo sapiens Myocardial Infarction heart tissues regulation[TGF-β1 Pathway] qRT-PCR//Wound Healing Assay//H&E Staining//FISH We found that lncRNA 554 was significantly up-regulated in the mouse hearts following MI. This suggests that the effects of lncRNA 554 on cardiac fibrosis is TGF-β1 dependent. Yes In vitro knockdown of lncRNA 554 by siRNA suppressed fibroblasts migration and expression of extracellular matrix (ECM); while overexpression of lncRNA 554 promoted expression of ECM genes. Consistently, lentivirus mediated in vivo knockdown of lncRNA 554 could inhibit cardiac fibrosis and improve cardiac function in mouse model of MI. 33390954 LNC_01977 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cells Regulation(SDF-1/CXCR4 pathway) qRT-PCR//Western Blot//Transwell Assay In vitro assays demonstrated that LncRNA01977 can significantly promote the progression of LUAD and that stromal cells in tumor microenvironment secrete chemokine CXCL12, also known as stromal derived factor-1 (SDF-1), and its receptor CXCR4 is low expressed in normal tissues and high expressed in LUAD tissues. Lung cancer patients with high expression of CXCR4 are more prone to metastasis. Yes In vitro assays demonstrated that LncRNA01977 can significantly promote the progression of LUAD and that stromal cells in tumor microenvironment secrete chemokine CXCL12, also known as stromal derived factor-1 (SDF-1), and its receptor CXCR4 is low expressed in normal tissues and high expressed in LUAD tissues. Lung cancer patients with high expression of CXCR4 are more prone to metastasis. 35402179 LNC_00312 LncRNA Homo sapiens Carcinoma, Renal Cell RCC cells,RCC tissues regulation[miR-34a-5p/ASS1 Axis] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay lncRNA was significantly downregulated in RCC cells such as A498 and ACHN; the expression of lncRNA 00312 in RCC tissues was significantly lower than that in adjacent normal tissues. Our study demonstrated that the lncRNA 00312/miR-34a-5p/ASS1 axis may play a functional role in the progression of RCC. Patients with low expression of lncRNA 00312 have worse prognosis regarding pathological grade, tumor size, and TNM stage. Yes Overexpression of lncRNA 00312 suppressed A498 and ACHN cell proliferation and invasion, while promoting apoptosis. 32308805 LNC_00152 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[JAK2/STAT3 pathway] Flow Cytometry//qRT-PCR//EdU Staining//Western Blot The expression of lncRNA 00152 in HCC tissues was significantly higher than that of matched para-cancerous tissues and normal liver tissues. Similarly, lncRNA 00152 was highly expressed in HCC cell lines when compared with that of normal liver cells.High expression of lncRNA 00152 promotes the development of HCC by activating the JAK2/STAT3 pathway. LncRNA 00152 expression was positively correlated with tumor stage and tumor size, whereas negatively correlated with the overall survival of HCC patients. Yes Knockdown of lncRNA 00152 in MHCC97 cells remarkably decreased the proliferative ability and arrested cell cycle. Overexpression of lncRNA 00152 in HB611 cells significantly promoted cell proliferation and cell cycle. 30779070 LNC_001089 LncRNA Homo sapiens Glioma glioma tissues Expression[lower expressed] CCK8//qRT-PCR//Transwell Assay LncRNA001089 was downregulated in glioma tissues, evaluated by qRT-PCR. Kaplan-Meier analysis indicated that the downregulation of LncRNA001089 expression was associated with poor prognoses in glioma patients. Multivariate analysis demonstrated that LncRNA001089 downregulation and WHO high-grade glioma were independent factors that both predicted poor outcomes for glioma patients. Yes Cells with LncRNA001089 stable overexpression exhibited decreased capacities for proliferation, migration, and invasion in vitro, and restrained nude mouse tumorigenesis in vivo, but LncRNA001089 overexpression enhanced apoptosis. 30868865 LNC_000898 LncRNA Mus musculus Myocardial Infarction marginal tissue of MI regulation[miR-375/PDK1 Axis] qRT-PCR//Western Blot The results indicated that LNC_000898 expression was downregulated in marginal tissue of MI and in NMCMs exposed to hypoxia.These data not only demonstrate that LNC_000898 could protect the heart against MI injury by regulating miR-375/PDK1 but also provide a new understanding to better protection of MI injury through the LNC_000898/miR-375/PDK1 axis. Yes Overexpression of LNC_000898 decreased cardiomyocyte apoptosis both in vivo and in vitro. 32398474 lnc_000231 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cells and tumour tissues regulation[ KDM5C/lnc_000231/miR-497-5p/CCNE1 signalling pathway ] RNA Pull-Down//Northern Blot//Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Recent studies with genome-wide sequencing on cervical squamous cell carcinoma and matched adjacent non-tumour tissues showed that a newly identified lncRNA-lnc_000231 was highly expressed in cervical cancers. E6 hijacked KDM5C/lnc_000231/miR-497-5p/CCNE1 signalling pathway is a promising target for cervical cancer treatment in the future. Yes In vitro and in vivo results showed that lnc_000231 promotes cervical cancer cell proliferation and tumour formation by acting as miR-497-5p sponge and maintaining cyclin E1 (CCNE1) expression. 32818316 LMCD1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(LMCD1-AS1/miR-526b-3p/OSBPL5 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay This paper was the first to probe the molecular regulatory mechanism of OSBPL5 involving the LMCD1-AS1/miR-526b-3p axis in NSCLC and our results revealed that the LMCD1-AS1/miR-526b-3p/OSBPL5 axis facilitates NSCLC cell proliferation, migration, invasion and EMT, which may offer a novel therapeutic direction for NSCLC. Yes Moreover, from rescue assays, we observed that OSBPL5 overexpression offset LMCD1-AS1 knockdown-mediated inhibition in cell proliferation, migration, invasion and EMT in NSCLC. 35000595 LMCD1-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines interaction[miR-106b-5p] qRT-PCR We found that LMCD1-AS1 and SP1 were highly expressed in osteosarcoma tissues and cell lines. Mechanistic studies revealed that LMCD1-AS1 was a sponge of miR-106b-5p activity. High levels of LMCD1-AS1 were correlated with positively metastasis and poor clinical prognosis. Yes Functionally, silencing of LMCD1-AS1 suppressed the proliferation, migration, invasion and EMT progress of osteosarcoma cells. 32248969 LMCD1-AS1 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues,cell lines Interaction[miR-345-5p/COL6A3 pathway] Immunoblotting//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay//ChIP In our study, we confirmed that LMCD1-AS1 expression was significantly higher in CCA tissues and cell lines than in normal tissues and HIBEC, respectively. In addition, LMCD1-AS1 could sponge miR-345-5p in CCA cells. Moreover, collagenVI-alpha3 chain (COL6A3) was found as a downstream target of miR-345-5p by bioinformatic prediction and dual luciferase reporter assay. Furthermore, we demonstrated that the oncogenic role of LMCD1-AS1 is partly dependent on COL6A3 expression. Yes Function study showed depletion of LMCD1-AS1 suppressed cell proliferation, clone formation and invasion, and induced apoptosis of CCA cells. 30876691 LL22NC03-N64E9.1 LncRNA Homo sapiens Breast Neoplasms BC tissues regulation[LL22NC03-N64E9.1/EZH2/KLF2 pathway] qRT-PCR//RIP//Transwell Assay We identified that LL22NC03-N64E9.1 is an oncogene, upregulated in BC, which was verified in a cohort of 48 pairs of BC tissues. Relying on the LL22NC03-N64E9.1/EZH2/KLF2 pathway, the lncRNA LL22NC03-N64E9.1 was significantly associated with BC development and could, therefore, be a potential therapeutic target to block BC growth. Yes Based on the loss-of-function experiments, silencing LL22NC03-N64E9.1 expression significantly inhibited malignancy progression. 33149681 LL22NC03-N64E9.1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissue,lung cancer cell lines Expression[highly expressed] CCK8//qRT-PCR//Colony Formation Assay In clinical tissue samples, the level of LL22NC03-N64E9.1 in patients with lung cancer was significantly increased compared with adjacent normal lung tissues (P<0.001). The level of LL22NC03-N64E9.1 in patients with lung cancer was significantly correlated with tumor size and TNM stage (P<0.05), but not with age, sex and the presence of lymph node metastasis (P>0.05). Yes In the H292 cells, following knockdown of LL22NC03-N64E9.1, cell proliferation and cloning were reduced. 29935018 LL22NC03-N14H11.1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[H-RAS/MAPK pathway] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Results showed that LL22NC03-N14H11.1 was upregulated in HCC tissues and cells. In conclusion, this study firstly revealed that lncRNA LL22NC03-N14H11.1 promoted HCC progression through activating H-RAS/MAPK pathway to induce mitochondrial fission, indicating LL22NC03-N14H11.1 as a novel potential biomarker for HCC treatment. Yes Functionally, LL22NC03-N14H11.1 contributed to cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) in HCC. 33028809 LIT3527 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Regulation(AKT/ERK/mTOR signaling pathway) In Vivo Experiment//Northern Blot//Wound Healing Assay//Immunoblotting//Migration Assay//CCK8//qRT-PCR//MTT//Cell Cycle Assay//Transwell Assay//IF Here, we screened differentially expressed lncRNAs in gastric cancer tissues and matched adjacent tissues and found that lncRNA LIT3527, a 486-nucleotide (nt) sense transcript, was frequently upregulated in gastric cancer tissues.Mechanistically, we uncovered that depletion of LIT35227 induced significant cell apoptosis and autophagy through inhibiting AKT/ERK/mTOR signaling pathway. Yes Knockdown of LIT3527 dramatically suppressed proliferation and migration of gastric cancer cells through inducing severe cell death but not affecting cell cycle. 34234860 LIPH-4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR-216b/IGF2BP2 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay We identified a novel lncRNA, LIPH-4, which showed elevated amounts in ESCC tissues and positive correlations with increased tumor size and poor prognosis in ESCC patients. In terms of mechanism, LIPH-4 could bind to miR-216b and act as a competing endogenous RNA (ceRNA) to induce the expression of miR-216's target gene IGF2BP2. LIPH-4 played an oncogenic role in ESCC through the miR-216b/IGF2BP2 axis. We identified a novel lncRNA, LIPH-4, which showed elevated amounts in ESCC tissues and positive correlations with increased tumor size and poor prognosis in ESCC patients. Yes Functional studies showed that LIPH-4 promoted the growth, mediated cell cycle progression and inhibited apoptosis in ESCC cells in vitro, and promoted tumor growth in mice. 35971159 LNC11649 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(MALAT1) RNA-seq Both northern blot and quantitative PCR analyses confirmed the presence of LNC11649 in NSCLC tissues and cells with high expression. Its sequence was found to be highly homologous to lncRNA MALAT1. Knocking down MALAT1 could lead to a significant downregulation of LNC11649 content, revealing the possibility that LNC11649 could originate from MALAT1 reprocessing. Yes Further experiments revealed that LNC11649 promoted the cytoplasmic distribution of MSI1 through its interaction with MSI1 and then activated the Akt signaling pathway to regulate the proliferation and migration of NSCLC cells. 36264775 lnc40589 LncRNA Homo sapiens Mammary Neoplasms, Animal CMTs Expression(highly expressed) In Vivo Experiment//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Colony Formation Assay//Bioinformatics Analysis lnc40589 was significantly upregulated and lnc34977 was significantly downregulated in CMTs. Yes In addition, lnc40589 inhibits cell proliferation, migration and invasion, while lnc34977 promotes cell proliferation, migration and invasion. In addition, lnc34977 promotes the development of mammary tumors in animals. 35202335 LINP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay FISH assay showed that LINP1 was expressed at low levels in normal esophageal tissues (Figure 2D), whereas it was highly expressed in ESCC and mainly expressed in the cytoplasm (Figure 2E). High LINP1 expression had close correlation with larger tumor size (P=0.009), tumor invasion (P=0.015), lymph nodes metastasis (P=0.044), and advanced TNM stage (P=0.010). LINP1 overexpression was an independent prognostic factor of ESCC patients (P=0.034). Yes LINP1 knockdown decreased the proliferative and migratory abilities of EC9706 cells, and promoted apoptosis and cell cycle arrest at the G2/GM phase. In the xenograft model, knockdown of LINP1 suppressed ESCC tumorigenesis in vivo. 32617295 Lnc408 LncRNA Homo sapiens Breast Neoplasms BCSCs Regulation(CBY1) Flow Cytometry//qRT-PCR//IHC//Western Blot The lnc408 is high expressed in BCSCs in vitro and in vivo. The enhanced lnc408 is critical to BCSC characteristics and tumorigenesis. Lnc408 can recruit transcript factor SP3 to CBY1 promoter to serve as an inhibitor in CBY1 transcription in BCSCs. In shortly, these findings highlight that the novel lnc408 functions as an oncogenic factor by recruiting SP3 to inhibit CBY1 expression and β-catenin accumulation in nucleus to maintain stemness properties of BCSCs. Yes In shortly, these findings highlight that the novel lnc408 functions as an oncogenic factor by recruiting SP3 to inhibit CBY1 expression and β-catenin accumulation in nucleus to maintain stemness properties of BCSCs. 33934099 lnc-Chaer LncRNA Mus musculus acute myocardial infarction oxygen-glucose deprivation (oxygen-glucose deprivation)-treated cardiomyocytes in vitro and AMI heart Regulation(AMPK Activation) CCK8//qRT-PCR//Western Blot Importantly, lncRNA Chaer is significantly downregulated in both oxygen-glucose deprivation (oxygen-glucose deprivation)-treated cardiomyocytes in vitro and AMI heart. Interestingly, overexpression of lncRNA Chaer promotes the phosphorylation of AMPK, and AMPK inhibitor Compound C reverses the overexpression of lncRNA Chaer effect of reducing cardiomyocyte apoptosis under OGD-treatment. Yes In vitro, overexpression of lncRNA Chaer with adeno virus reduces cardiomyocyte apoptosis induced by OGD-treated while silencing of lncRNA Chaer increases cardiomyocyte apoptosis instead. In vivo, forced expression of lncRNA Chaer with AAV9 attenuates cardiac apoptosis, reduces infarction area and improves mice heart function in AMI. 34335241 lnc-CES1-1 LncRNA Homo sapiens Abortion, Habitual URPL patients and decidua-associated cell lines (DACs). Regulation(FUS/PPARγ ) Western Blot//qRT-PCR//RIP//IF//RNA-seq//migration assay//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//ELISA//ChIP Through comprehensive screening and validation, we identified a decidua-enriched eRNA long noncoding-CES1-1 (lnc-CES1-1) enriched in URPL patients and studied its function in decidua-associated cell lines (DACs).Upon activation by signal transduction and activation of transcription 4 (STAT4), lnc-CES1-1 interacted with the transcription factor fused in sarcoma (FUS) to upregulate the expression of PPARγ and affected cell migration. Yes Higher expression of lnc-CES1-1 increased the level of inflammatory factors tumor necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β) and impaired the cell migration ability, which was attenuated by downregulating peroxisome proliferators-activated receptor γ (PPARγ). 33738142 lnc-CCNL1-3:1 LncRNA Homo sapiens Polycystic Ovary Syndrome human luteinized granulosa cells Interaction(FOXO1) Transfection//Immunoblotting//Tunel//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//IF The interaction of CCNL with FOXO1 might prevents FOXO1 exclusion from the nucleus and subsequent degradation in the cytosol. Yes In KGN cells and hLGCs, CCNL overexpression upregulated FOXO1 expression, promoted cell apoptosis, reduced glucose transport capability, and impaired mitochondrial function, and these effects were partially abolished by silencing FOXO1. 33552682 lncCCLM LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression(lower expressed) RNA Pull-Down//Transfection//Tube Formation Assay//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Microarray//ELISA//Transwell Assay//Bioinformatics Analysis//IF Herein, through RNA screening, we identified a novel long noncoding RNA (lncRNA), LncCCLM, that was downregulated in cervical cancer tissues and closely associated with lymphatic metastasis in cervical cancer patients. Mechanistically, LncCCLM localized in the cytoplasm and interacted with staufen double-stranded RNA binding protein 1 (STAU1), promoting the binding of the STAU1 protein to the 3' untranslated region (3'UTR) of insulin-like growth factor 1 (IGF-1) mRNA, which accelerated the degradation of IGF-1 mRNA and decreased the IGF-1 protein level, ultimately reducing lymphangiogenesis and lymphatic metastasis in cervical cancer. Herein, through RNA screening, we identified a novel long noncoding RNA (lncRNA), LncCCLM, that was downregulated in cervical cancer tissues and closely associated with lymphatic metastasis in cervical cancer patients. Yes Gain-of-function and loss-of-function studies in CC cells demonstrated that LncCCLM inhibited cervical cancer-associated lymphangiogenesis, and CC cell migration and invasion in vitro and suppressed LN metastasis in vivo, but did not affect the growth of CC cells. 34273467 lnc-CCAT1 LncRNA Homo sapiens Prostatic Neoplasms PCa and corresponding adjacent normal prostate tissues Interaction(miR-490-3p/FRAT1 axis) Western Blot//Bioinformatics Analysis//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay qRT-PCR results showed that CCAT1 was upregulated in PCa tissues and cells. We also found that CCAT1 negatively regulated miR-490-3p expression and subsequently regulated FRAT1 expression. Inhibition of miR-490-3p or up-regulation of FRAT1 reversed the suppressive effects of CCAT1 knockdown on the PCa cells. Yes Functional assays demonstrated that CCAT1 knockdown suppressed cell proliferation, migration, invasion, yet promoted apoptosis, while CCAT1 promotion showed the opposite results. 34319909 lncCCAT1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,Breast cancer stem cells Regulation[WNT/β-catenin Signaling] RIP//ChIP//Microarray LncCCAT1 is markedly upregulated in breast cancer tissues BCSCs and is correlated with poor outcomes in breast cancer patients. Mechanistic investigation suggests that LncCCAT1 can interact with miR-204/211, miR-148a/152 and Annexin A2(ANXA2), then upregulate T-cell factor 4 (TCF4) or promote translocation of β-catenin to the nucleus where it activates TCF4, leading to the activation of wingless/integrated (Wnt) signaling. LncCCAT1 is markedly upregulated in breast cancer tissues BCSCs and is correlated with poor outcomes in breast cancer patients. Yes  Overexpression of LncCCAT1 contributes to the proliferation, stemness, migration and invasion capacities of BCSCs.  31695775 lncCCAT1 LncRNA Homo sapiens Osteosarcoma HeLa cells & human OS cell line Interaction(PKM2) qRT-PCR//Western Blot Peak calling analysis revealed that PKM2 binds to long noncoding RNAs (lncRNAs), which are associated with cancer pathogenesis and development. Validation of the PKM2‑lncRNA interaction in the human OS cell line revealed that lncRNA colon cancer associated transcript‑1 (lncCCAT1) interacted with PKM2, which upregulated the phosphorylation of sterol regulatory element‑binding protein 2 (SREBP2). These factors promoted the Warburg effect, lipogenesis, and OS cell growth. PKM2 appears to be a key regulator in OS by binding to lncCCAT1. This further extends the biological functions of PKM2 in tumorigenesis and makes it a novel potential therapeutic for OS. Peak calling analysis revealed that PKM2 binds to long noncoding RNAs (lncRNAs), which are associated with cancer pathogenesis and development. Yes Validation of the PKM2‑lncRNA interaction in the human OS cell line revealed that lncRNA colon cancer associated transcript‑1 (lncCCAT1) interacted with PKM2, which upregulated the phosphorylation of sterol regulatory element‑binding protein 2 (SREBP2). 35244192 LNCBRM LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells regulation[microRNA-331-3p/SLC25A1 axis] CCK8//qRT-PCR//Transwell Assay//Western Blot Reverse transcription-quantitative PCR assays revealed that lncBRM was upregulated in PTC tissues and cells. In conclusion, the present study suggests that lncBRM promotes PTC by regulating miR-331-3p and targeting SLC25A1. Furthermore, high expression of lncBRM was associated with poor overall survival time in patients with PTC. Yes lncBRM knockout significantly suppressed cell proliferation, migration and invasion. 32218861 lncAY927529 LncRNA Homo sapiens Prostatic Neoplasms PC3 and DU145 cells Interaction(CXCL14 ) RNA Pull-Down//Western Blot//qRT-PCR//Cell Apoptosis Assay//ELISA RT-qPCR assay indicated that lncAY927529 level was downregulated in PC3 and DU145 cells, exosomes derived from PCa cells (PCa-Exo) and ST2-CM treated with PCa-Exo with low expression of lncAY927529, and overexpression of lncAY927529 had the opposite results. In addition, Western blot assay showed that the autophagy related protein LC3II level was increased in ST2 cells treated with exosomes derived from DU145 cells with high expression of lncAY927529, and LC3I protein level was decreased. CXCL14 acted as a RNA-binding protein of lncAY927529, and exosome-mediated lncAY927529 positively regulated CXCL14 levels in ST2 cells. Yes In general, exosome-mediated lncAY927529 could promote PCa cell proliferation and invasion by regulating bone microenvironment, suggesting that exosomal lncAY927529 may be a potential molecular diagnostic marker of PCa. 34724861 lnc-ATB LncRNA Homo sapiens Ovarian Neoplasms OC tissues interaction[binding to EZH2] qRT-PCR//RNA Pull-Down//RIP In our research, lnc-ATB expression in OC tissues was elevated compared with adjacent normal tissues and high expression of lnc-ATB was associated with poor outcomes of OC patients. RNA immunoprecipitation and RNA pull-down results showed that lnc-ATB positively regulated the expression of EZH2 via directly interacting with EZH2. In our research, lnc-ATB expression in OC tissues was elevated compared with adjacent normal tissues and high expression of lnc-ATB was associated with poor outcomes of OC patients. Yes The silencing of lnc-ATB blocked cell proliferation, invasion and migration in SKOV3 and A2780 cells. 33336896 lnc-ATB LncRNA Homo sapiens Endometrial Neoplasms EC tissues,cell lines Interaction[PIK3R2/Sox2 signals ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay The expression of Lnc-ATB is up-regulated in tumor tissues and EC cell lines.These data demonstrate the tumorigenic role of Lnc-ATBs in endometrial cancer via abrogation of tumor suppressor miR-126 signals. Yes Knockdown of Lnc-ATB in RL95 and HEC1A cell lines increased the miR-126 level and impaired the cell vitality, induced caspase-3-related tumor apoptosis and G1/S arrest. Knockdown of Lnc-ATB in vivo remarkably induced tumor regression via restoration of tumor suppressor miR-126 30601064 LNCARSR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[lncARSR/miR-34a-5p/HK1 ] qRT-PCR//Luciferase Report Assay//RIP//Western Blot Here, we analyzed specimens from 89 patients with CRC and demonstrated that lncARSR was highly expressed in CRC tissues and negatively associated with survival.Collectively, we identified lncARSR as an onco-lncRNA in CRC and demonstrated that the combination of lncARSR/miR-34a-5p/HK1 may be a potential prognostic biomarker of CRC. Here, we analyzed specimens from 89 patients with CRC and demonstrated that lncARSR was highly expressed in CRC tissues and negatively associated with survival. Yes Functionally, ectopic expression of lncARSR promoted the invasion, metastasis, and glycolysis metabolic reprogramming of CRC cells in vitro and in vivo, while these activities were inhibited by silencing lncARSR expression. 32798250 LNCARSR LncRNA Homo sapiens Carcinoma, Renal Cell exosomes Interaction(miR-34/miR- 449/STAT3 ) qRT-PCR//RNA Pull-Down//FISH Further study revealed high amount of a recently discovered lncRNA called lncARSR in RCC-derived exosomes. LncARSR interacts directly with miR-34/miR- 449 to increase STAT3 expression and mediate macrophage polarization in RCC cells. Yes Overexpression of lncARSR induced phenotypic and functional changes of macrophages in vitro and promoted tumor growth in vivo, while knockdown of lncARSR by siRNA disrupted the exosomes-mediated macrophage polarization. 35637970 LNCARSR LncRNA Homo sapiens Urinary Bladder Neoplasms Bca tissue regulation[SOX4 ] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay In this study, we discovered that lncARSR was significantly up-regulated in bladder cancer. Mechanistically, lncARSR was mainly located in the cytoplasm and acted as a miRNA sponge to positively modulate the expression of Sex-determining region Y-related high-mobility-group box transcription factor 4 (SOX4) via sponging miR-129-5p and subsequently promoted the proliferation and metastasis of Bca cells, thus playing an oncogenic role in Bca pathogenesis. In addition, increased expression of lncARSR was positively correlated with higher histological grade and larger tumor size. Yes Further experiments demonstrated that suppression of lncARSR attenuated the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process of Bca cells. 31892841 LNCARSR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[PTEN/Akt] qRT-PCR//Western Blot In the present study, it was demonstrated that lncARSR expression was higher in NSCLC tissues than in noncancerous tissues. Furthermore, we demonstrated that overexpression of lncARSR induced NSCLC cell growth and migration via regulating the PTEN/Akt signaling pathway. Yes Further investigation demonstrated that increased lncARSR expression promoted NSCLC cell migration and growth and induced epithelial-mesenchymal transition in A549 cells. 32269718 lnc-AGER-1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues interaction[sponging miR-182] qRT-PCR We found that the expression of lnc-AGER-1 in the tumor tissues was significantly down-regulated, while compared with adjacent normal tissues (0.0115 ± 0.0718 vs. 0.0347 ± 0.157; P < 0.0001). Further research proved that lnc-AGER-1 altered the expression of its neighbor gene, AGER, through acting as a competing endogenous RNA for miR-182 in colorectal cancer. Also, lnc-AGER-1 was observably associated with clinical T status (r = -0.184, P = 0.024). Patients with advanced T status exerted a significantly lower level of lnc-AGER-1 than those with early T status (20.0% vs. 40.7%, P = 0.021). Yes Over-expression of lnc-AGER-1 inhibited cell proliferation and migration efficiency, and induced cell cycle arrest at the G0/G1 phase, and promoted cell apoptosis. 32031046 lnc-ADD3-AS1 LncRNA Homo sapiens Liver Cirrhosis LX-2 cell Regulation Transfection//Wound Healing Assay//Flow Cytometry//Cell Proliferation Assay//Transwell Assay Our results show that lnc-ADD3-AS1 significantly promoted LX-2 cell proliferation and attenuated apoptosis. More importantly, lncRNA-ADD3-AS1 significantly accelerated the migration of LX-2 cells. Yes Our results show that lnc-ADD3-AS1 significantly promoted LX-2 cell proliferation and attenuated apoptosis. More importantly, lncRNA-ADD3-AS1 significantly accelerated the migration of LX-2 cells. 35246014 lnc-ABCA12-3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tumor tissues and cell lines Regulation[regulate FN1] qRT-PCR We showed that lnc-ABCA12-3 was upregulated in ESCC tumor tissues and cell lines. Further studies indicated that lnc-ABCA12-3 acted as a competing endogenous RNA for miR-200b-3p to regulate FN1 expression. Yes The knockdown of lnc-ABCA12-3 inhibited the cell migration, invasion, and proliferation abilities of KYSE-510 and Eca-109 cells. 31512786 Lnc-408 LncRNA Homo sapiens Breast Neoplasms BC cells undergoing EMT and in BC tumor with lymphatic metastases Interaction(miR-654-5p/LIMK1 axis) Western Blot//Migration Assay//IF//Luciferase Report Assay//Invasion Assay//Transwell Assay Here, we found that Lnc-408, a novel long noncoding RNA (lncRNA), is significantly upregulated in BC cells undergoing EMT and in BC tumor with lymphatic metastases compared with those without lymphatic metastases. In conclusion, our findings reveal that Lnc-408 promotes BC invasion and metastasis via the Lnc-408/miR-654-5p/LIMK1 axis, highlighting a novel promising target for the diagnosis and treatment of BC. Yes Lnc-408 can enhance BC invasion and metastasis by regulating the expression of LIMK1. 34079084 LIPCAR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC blood samples and HCC cell lines Expression(highly expressed) qRT-PCR LIPCAR was significantly upregulated in HCC blood samples and HCC cell lines compared to their respective normal ones. Yes Its overexpression promoted hepatocellular carcinoma cell proliferation, and migration, while inhibiting apoptosis. Its overexpression also promoted epithelial-mesenchymal transformation in hepatocellular carcinoma cells, and metastasis in vivo. 36336923 LINP1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and PTC cells regulation[AMPK signaling pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay It was shown in qRT-PCR results that LINP1 expression was upregulated in 42 out of 53 cases of PTC tissues and in all PTC cells. The transcription factor STAT1 promotes the expression of LINP1 in PTC, and highly expressed LINP1 facilitates the proliferation and inhibits the apoptosis of PTC by suppressing the AMPK signaling pathway. Yes After interference in the expression of LINP1 in PTC cells, the results of CCK-8 and colony formation assays indicated that the proliferative capacity of the cells was repressed. 32964981 lncROR LncRNA Homo sapiens Polycystic Ovary Syndrome PCOS patients Interaction(miR-206/VEGF ) Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay Highly expressed lncROR indirectly up-regulated the expression of VEGF by down-regulating the expression of miR-206, thereby promoting the proliferation of KGN cells and inhibiting apoptosis, and further promoting the development of PCOS. Yes Highly expressed lncROR indirectly up-regulated the expression of VEGF by down-regulating the expression of miR-206, thereby promoting the proliferation of KGN cells and inhibiting apoptosis, and further promoting the development of PCOS. 34148561 LINC-PINT LncRNA Homo sapiens Stomach Neoplasms Gastric Cancer tissues Interaction[PTCSC3 ] CCK8//qRT-PCR PTCSC3 and lncRNA Linc-pint were both downregulated in tumor tissues than in adjacent healthy tissues of gastric cancer patients. PTCSC3 and Linc-pint overexpression inhibited tumor growth and cancer cell stemness, while Linc-pint knockdown played an opposite role an attenuated the effects of PTCSC3 overexpression. Expression levels of PTCSC3 and Linc-pint were significantly correlated in tumor tissues but not in adjacent healthy tissues. Overexpression of PTCSC3 and Linc-pint upregulated the expression of each other. Low levels of PTCSC3 and Linc-pint were closely correlated with poor survival. Yes PTCSC3 and Linc-pint overexpression inhibited tumor growth and cancer cell stemness, while Linc-pint knockdown played an opposite role an attenuated the effects of PTCSC3 overexpression. 31849528 LINC-PINT LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma Interaction(miRNA-21) qRT-PCR downregulation of LINC-PINT participated in the recurrence of ESCC possibly by interacting with miRNA-21. LINC-PINT expression was further downregulated in recurrent patients but not in nonrecurrent patients. Yes Overexpression of LINC-PINT could inhibit the expression of miRNA-21 in human ESCC cells, whereas LINC-PINT expression was not altered by miR-21 overexpression. 32401035 LINC-PINT LncRNA Homo sapiens Ovarian Neoplasms OC tissues,cell lines (A2780, SKOV3, OVCAR3 and HO-8910) interaction[targeting miR-374a-5p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Low expression of LINC-PINT was observed in OC tissues and cells, noticeably, LINC-PINT expression was even lower in OC tissues with higher FIGO stage.The current study aimed to explore the role of LINC-PINT in the progression of ovarian cancer (OC) and found that LINC-PINT inhibited cell proliferation, migration invasion and EMT process of OC cell via regulating miR-374a-5p; it might be a potential target for OC treatment. Low expression of LINC-PINT was observed in OC tissues and cells, noticeably, LINC-PINT expression was even lower in OC tissues with higher FIGO stage. Yes Increased LINC-PINT expression significantly inhibited cell proliferation, promoted apoptosis and suppressed migration, invasion and EMT process, while silencing of LINC-PINT caused the opposite results. 32638404 LINC-PINT LncRNA Homo sapiens Osteosarcoma Osteosarcoma tissues Interaction[Downregulating miRNA-21] qRT-PCR In this study, we found that LncRNA LINC-PINT was inhibited, whereas miRNA-21 was promoted in tumor tissues than in adjacent healthy tissues of patients with osteosarcoma. LncRNA LINC-PINT and miRNA-21 were significantly and reversely correlated in both tumor cells and adjacent healthy tissues. LncRNA LINC-PINT overexpression led to downregulated miRNA-21 expression in cancer cells, whereas miRNA-21 overexpression did not significantly affect LINC-PINT expression. Expression levels of LncRNA LINC-PINT were affected by both tumor size and tumor metastasis. Yes Overexpression of LncRNA LINC-PINT inhibited whereas miRNA-21 overexpression promoted cancer cell proliferation, migration, and invasion. 31070482 LINC-PINT LncRNA Homo sapiens pancreatic ductal adenocarcinoma blood Regulation[TGF-β pathway ] CCK8//qRT-PCR//ELISA The results demonstrated that Linc-pint plasma levels were significantly lower in patients with stage 0-1 PDAC compared with healthy controls. In conclusion, results from the present study suggested that Linc-pint may inhibit early stage PDAC growth through TGF-β pathway activation. Yes Linc-pint overexpression and TGF-β1 both inhibited PDAC cell proliferation, whereas treatment with a TGF-β inhibitor reduced their inhibitory effects on cell proliferation. 30944652 LINC-PINT LncRNA Homo sapiens Glioblastoma cell lines regulation[Wnt/β-Catenin Signaling] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//IF//Colony Formation Assay//Transwell Assay LINC-PINT was downregulated in GBM cell lines.LINC-PINT suppressed cell proliferation, invasion, and EMT by blocking Wnt/β-catenin signaling in GBM. Yes LINC-PINT suppressed cell progression, invasion, and EMT in GBM. LINC-PINT blocked Wnt/β-catenin signaling in GBM. 33505307 LINC-PINT LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues regulation[miR-767-5p/TET2 axis] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay LINC-PINT expression was downregulated in thyroid cancer relative to adjacent normal tissues (p = 0.0002). Taken together, LINC-PINT functions as a tumor suppressor in thyroid cancer via the miR-767-5p/TET2 axis, representing a potential therapeutic target for thyroid cancer. Low expression of LINC-PINT was significantly associated with advanced tumor node metastasis (TNM) stage (p = 0.0306) and lymph node metastasis (p = 0.0359). Yes Ectopic expression of LINC-PINT suppressed the proliferation, invasion, and tumorigenesis of thyroid cancer cells. 33230437 LINC-PINT LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Hep-2 and TU-177 cells Interaction(ZEB1/AKT/mTOR pathway) qRT-PCR//Western Blot LINC-PINT expression was inhibited in LSCC tissues and in Hep-2 and TU-177 cells, whose downregulation was associated with unsatisfactory prognosis.LINC-PINT enriches EZH2 to silence ZEB1 and thus inhibits the proliferative, migratory, and invasive capacities of Hep-2 and TU-177 cells. In addition, LINC-PINT might exert its biological function through the AKT/mTOR pathway. LINC-PINT expression was inhibited in LSCC tissues and in Hep-2 and TU-177 cells, whose downregulation was associated with unsatisfactory prognosis. Yes LINC-PINT overexpression suppressed the proliferative, migratory and invasive capacities of Hep-2 and TU-177 cells. 34257531 LINC-PINT LncRNA Homo sapiens Retinoblastoma cell lines regulation[inhibits miR-523-3p ,upregulating Dickkopf-1 (DKK1)] qRT-PCR//RNA Pull-Down//Luciferase Report Assay Mechanistically, Linc-PINT was low-expressed, while miR-523-3p was high-expressed in RB cells, compared to the normal retinal epithelial cells (ARPE-19).In general, analysis of the data suggested that Linc-PINT inhibited miR-523-3p to upregulate DKK1, resulting in the inhibition of RB, and we demonstrated that Linc-PINT and miR-523-3p could be utilized as potential diagnostic and therapeutic biomarkers for RB in clinic. Yes Further gain- and loss-function experiments verified that both upregulation of Linc-PINT and miR-523-3p downregulation slowed down cell growth, invasion and migration, and promoted cell apoptosis in RB cells, but Linc-PINT ablation and miR-523-3p overexpression promoted malignant phenotypes in RB cells. 32828314 LINC-PINT LncRNA Homo sapiens Melanoma melanoma tissues Interaction[downregulating lncRNA BANCR] CCK8//qRT-PCR LINC-PINT was downregulated, while BRAF-activated non-coding RNA (BANCR) was upregulated in melanoma tissues compared with normal adjacent tissues. LINC-PINT was downregulated, while BRAF-activated non-coding RNA (BANCR) was upregulated in melanoma tissues compared with normal adjacent tissues. Expression levels of LINC-PINT decreased, while expression levels of BANCR increased with increasing tumor thickness. The expression levels of LINC-PINT and BANCR were inversely associated in melanoma tissues but not in healthy adjacent tissue. LINC-PINT overexpression downregulated BANCR expression in melanoma cells, while BANCR overexpression did not significantly affect LINC-PINT expression. Yes LINC-PINT overexpression inhibited melanoma cell proliferation in vitro compared to controls. 31452772 LINC-PINT LncRNA Homo sapiens Melanoma cell lines Interaction[Recruiting EZH2] CCK8//qRT-PCR//Flow Cytometry//Microarray//Colony Formation Assay//ChIP LINC-PINT was significantly downregulated in melanoma tissues and cell lines. In conclusion, LINC-PINT inhibits the tumorigenicity of melanoma through recruiting EZH2 to the promoter of its target genes, leading to H3K27 trimethylation and epigenetic silencing of target genes. Yes The overexpression of LINC-PINT in tumor cells resulted in significant tumor growth reduction and migration inhibition in A375, Mum2B and CRMM1 cells. Results based on the in vivo xenograft model were further consistent with the in vitro findings that LINC-PINT impeded growth and metastasis of melanoma cells. 31921860 LINC-PINT LncRNA Homo sapiens Diabetes Mellitus blood Expression qRT-PCR A comparison was made in this study, where LINC-PINT did not experience significant downregulation level in the majority of those suffering diabetes complications when in contrast to healthy controls, while LINC-PINT expression was found in diabetics. Yes While the overexpression of LINC-PINT increased the viability of ARPE-19 and AC16 cells, siRNA-mediated silencing of LINC-PINT elicited the opposite effect. 31711064 Linc8087 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Expression(lower expressed) Wound Healing Assay//qRT-PCR//Cell Viability Assay//Colony Formation Assay//Invasion Assay//Transwell Assay We found that linc8087 expression was obviously decreased in both NSCLC tissues and cell lines compared with paired normal tissues and a normal bronchial epithelium cell line. The result of RT2 Profiler PCR Array showed that overexpressed linc8087 upregulated the expression of the COL4A2, CST7 and FAT1 genes and led to the downregulation of SERPINE1. Low expression of linc8087 was significantly associated with poor survival. In addition, linc8087 was an independent risk factor for survival. Yes Overexpressed linc8087 inhibited cell migration and invasion in A549 and PC9 cell lines. Knockdown of linc8087 promoted cell migration and invasion. 34391179 LINC0638 LncRNA Homo sapiens Melanoma blood Expression[highly expressed] qRT-PCR LINC01638 lncRNA was significantly upregulated in patients with melanoma compared with the other two groups of patients, and upregulation of LINC01638 lncRNA distinguished patients with melanoma from patients with benign skin lesions and healthy controls. Yes LINC01638 lncRNA overexpression promoted, while knockdown inhibited proliferation of cells of melanoma cell lines, C32 and SK-MEL-28, in vitro. 31289478 LINC03047 LncRNA Homo sapiens Breast Neoplasms clinical breast cancer tissues Interaction(IGF2BP1/c-Myc axis) qRT-PCR//Bioinformatics Analysis Here, using RNA sequencing (RNA-seq) analysis, we identified a hypoxia-induced long noncoding RNA (lncRNA) KB-1980E6.3, which is aberrantly upregulated in clinical breast cancer tissues and closely correlated with poor prognosis of breast cancer patients. Mechanistically, lncRNA KB-1980E6.3 recruited insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) to form a lncRNA KB-1980E6.3/IGF2BP1/c-Myc signaling axis that retained the stability of c-Myc mRNA through increasing binding of IGF2BP1 with m6A-modified c-Myc coding region instability determinant (CRD) mRNA. Here, using RNA sequencing (RNA-seq) analysis, we identified a hypoxia-induced long noncoding RNA (lncRNA) KB-1980E6.3, which is aberrantly upregulated in clinical breast cancer tissues and closely correlated with poor prognosis of breast cancer patients. Yes The enhanced lncRNA KB-1980E6.3 facilitates breast cancer stem cells (BCSCs) self-renewal and tumorigenesis under hypoxic microenvironment both in vitro and in vivo. 33469161 LINC03047 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Regulation(PI3K/AKT signalling pathway) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The levels of KB-1980E6.3 are significantly upregulated in breast cancer tissues and cells and are related to the poor prognosis. In terms of the mechanism, KB-1980E6.3 is involved in the activation of the PI3K/AKT signalling pathway. Knockdown of KB-1980E6.3 reduced the expression of the p-PI3K and p-AKT proteins, whereas KB-1980E6.3 overexpression showed the opposite result. The levels of KB-1980E6.3 are significantly upregulated in breast cancer tissues and cells and are related to the poor prognosis. Yes Functional research both in vivo and in vitro revealed that the downregulation of KB-1980E6.3 expression significantly decreased cell proliferation, invasion and migration, while ectopic KB-1980E6.3 expression obviously promoted these biological phenotypes. 35461041 LINC03046 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[MicroRNA-432-3p/ZEB1 Axis and the Wnt/β-Catenin Signaling Pathway] Western Blot//ISH//qRT-PCR//IF//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The current study aimed to explore the function and molecular mechanism of lncRNA AC010789.1 in CRC progression. AC010789.1 found to be overexpressed in CRC tissues and cells.In summary, these results reveal that silencing AC010789.1 suppresses CRC progression via miR-432-3p-mediated ZEB1 downregulation and suppression of the Wnt/β-catenin signaling pathway, highlighting a potentially promising strategy for CRC treatment. High expression of AC010789.1 was associated with lymph node metastasis and poor prognosis. Yes Moreover, AC010789.1 silencing inhibited proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in vitro as well as tumorigenesis and metastasis in vivo. 33178684 LINC02990 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue specimens and cells Interaction(miR-767-3p) CCK8//qRT-PCR//Invasion Assay LncRNA RP11-909N17.2 has an ascendant expression while miR-767-3p has descended one in NSCLC tissue specimens and cells. Over-expression of lncRNA RP11-909N17.2 can shorten the overall survival period of NSCLC patients when compared with low expression. Yes Knockdown of lncRNA RP11-909N17.2 suppressed biology function of NSCLC cell including proliferation, migration, and invasion. 34957995 LINC02987-201 LncRNA Homo sapiens Endometrial Neoplasms endometrial cancer cell lines Interaction(miR-424/E2F6/E2F7 Axis) CCK8//qRT-PCR//Wound Healing Assay Combined with the results of the previous study, PCR analysis confirmed that lncRNA E27 was significantly upregulated in endometrial cancer cell lines. Furthermore, based on bioinformatics predictions, dual-luciferase assay and RT-qPCR analysis confirmed that miR-424, as its downstream molecule, competitively regulates the expression of E2F6/E2F7. Rescue experiments further supported that lncRNA E27 inhibited proliferation, migration, invasion, and promoted apoptosis of endometrial cancer through miR-424/E2F6/E2F7 signaling axis. Yes The results of CCK-8, wound healing assay, and transwell experiments showed that lncRNA E27 could significantly inhibit cell proliferation, migration, and invasion. Flow cytometry results confirmed that lncRNA E27 could promote apoptosis. 36525235 LINC-PINT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissues interaction[sponging miR-543 and inducing PTEN] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Firstly, in our study, we implied that LINC-PINT was obviously decreased in NSCLC. All these findings concluded that LINC-PINT exerted crucial biological roles in NSCLC through sponging miR-543 and inducing PTEN. Yes As exhibited, LINC-PINT repressed cell proliferation and cell colony formation of A549 and H1299 cells. 31981466 LINC-PINT LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[miR-21] qRT-PCR In the present study, we found that lncRNA LINC-PINT was downregulated, while microRNA-21 (miR-21) was upregulated in tumor tissues than in adjacent healthy tissues of gastric cancer patients. LINC-PINT overexpression casued miR-21 inhibition in cells of human gastric cancer cell lines, while miR-21 overexpression did not alter LINC-PINT expression.. Effects of LINC-PINT overexpression on cellular behaviors of gastric cancer cells were attenuated by miR-21 overexpression. Therefore, LINC-PINT may participate in gastric cancer through the crosstalk with miR-21. Yes LINC-PINT overexpression led to inhibited, while miR-21 overexpression led to promoted proliferation, migration, and invasion of gastric cancer cells. 30569513 LINP1 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic tumor tissue interaction[adsorbing microRNA-491-3p] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay QRT-PCR revealed that lncRNA LINP1 showed a significantly higher expression in pancreatic tumor tissue samples than in adjacent normal ones. LncRNA LINP1 is able to enhance the proliferation and metastasis of PCa cells by modulating microRNA-491-3p, thus affecting the incidence of lymph node or distant metastasis and prognosis of patients with PCa. Compared with patients with low expression of lncRNA LINP1, patients with highly expressed lncRNA LINP1 showed a higher incidence of distant metastasis, but a lower overall survival rate. Yes In addition, compared to the sh-NC group, the proliferation, invasion, and migration ability of PCa cells decreased remarkably in LINP1 knockdown group. 33015772 LincRNA00494 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissues regulation[SRCIN1 ] CCK8//qRT-PCR LincRNA00494 was downregulated in the tumor tissues compared with the adjacent non-tumor tissues.Functional experiments revealed that LincRNA00494 inhibited NSCLC cell proliferation, which might be related to the suppression of SRCIN1, a tumor suppressor gene, by acting as a decoy for miR-150-3p. Yes Tumor growth from LincRNA00494-overexpressing xenografts was significantly decreased; additionally, LincRNA00494 silencing substantially increased tumor growth compared with that of the control cells. 32117734 LINP1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and normal tissues Regulation[PI3K/AKT signaling pathway] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay LINP1 was proved to be Expression[Expression[up-expression]-expression]-regulated in EC cell lines and tissues by qRT-PCR assay. CCK-8 assay and colony formation assay were conducted and the results indicated that LINP1 over-expression can promote cell proliferation in EC in vitro. The data of transwell and Matrigel assays indicated that Expression[Expression[up-expression]-expression]-regulated LINP1 can facilitate cell migration and invasion. The results of Western blotting validated that LINP1 can activate PI3K/AKT signaling. Besides, the tumor formation assay verified that LINP1 can promote tumor formation in vivo. Yes CCK-8 assay and colony formation assay were conducted and the results indicated that LINP1 over-expression can promote cell proliferation in EC in vitro. The data of transwell and Matrigel assays indicated that Expression[Expression[up-expression]-expression]-regulated LINP1 can facilitate cell migration and invasion. 31486482 Linc-UROD LncRNA Homo sapiens Pancreatic Neoplasms PC cells Regulation(GF2BP3/METTL3/ENO1 and PKM) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Colony Formation Assay//Transwell Assay The expression of linc-UROD was found to be upregulated in PC cells. Through mechanistic experiments, we found that IGF2BP3 stabilized linc-UROD through METTL3-mediated m6A modification. In addition, linc-UROD enhances the stability of ENO1 and PKM through interacting with them to inhibit ubiquitination. Detection on glucose consumption, pyruvate kinase activity and lactate production indicated that linc-UROD accelerated glycolysis of PC cells through PKM/ENO1-mediated pathway. Yes The results of loss-of-function assays demonstrated that linc-UROD knockdown suppressed cell proliferation and migration, induced cell cycle G0/G1 arrest, and accelerated apoptosis of PC cells. 36413861 LINC-ROR LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(miR-212-3p/FGF7 Axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay We found that Linc-ROR were overexpressed in GC tissues compared to the adjacent tissues.Overexpression of miR-212-3p facilitated GC cells' migration and invasion, while the silencing of miR-212-3p attenuated GC cell migratory and invasive abilities. Fibroblast growth factor 7 (FGF7), a downstream molecule of miR-212-3p, was overexpressed in GC cells. High Linc-ROR predicts poor prognosis of GC patients. Yes Moreover, Linc-ROR knockdown significantly suppressed the proliferation, migration, and invasion of GC cells, whereas miR-212-3p antagomir partially reversed Linc-ROR knockdown-induced phenotypes. 33564265 LINC-ROR CircRNA Homo sapiens Breast Neoplasms  breast cancer tissues Interaction(MLL1) RNA Pull-Down//ChIP//Western Blot//ISH//Flow Cytometry//FISH//RIP//IP//CHIP//EdU Staining//Transwell Assay LncRNA ROR overexpresses in breast cancer tissues Yes Silencing of lncRNA ROR inhibits cell proliferation and invasion, promotes apoptosis in breast cancer 33653378 LINC-ROR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tumor tissues and cells Interaction(miR-145/FSCN1) Western Blot//Migration Assay//qRT-PCR//Invasion Assay//Transwell Assay ROR expression in ESCC tumor tissues was significantly higher than in the adjacent tissues, p<0.001. ROR overexpression could downregulate miR-145 by up to 50% was proven by RIP, DLR assay, and qRT-PCR. Two effective binding sites of ROR to miR-145 were verified by DLR assay. One of the sites has never been cited in the literature. The Western blotting results showed that FSCN1 was a downstream target of ROR/miR-145 (p<0.05). The survival rate of ESCC patients with high ROR expression levels was lower than that of patients with low ROR expression levels (p<0.001). Yes Transwell assays were used to show that overexpression of ROR enhanced migration and invasion behavior of ESCC and miR-145 hindered these effects. 29430188 LINC-ROR LncRNA Homo sapiens Colorectal Neoplasms CRC cell lines and tissues regulation[miR-6833-3p/SMC4 pathway] Flow Cytometry//qRT-PCR//Luciferase Report Assay//RIP In this study, we found that LINC-RoR was upregulated in CRC cell lines and tissues.We concluded that LINC-RoR functions as an oncogene in CRC through the miR-6833-3p/SMC4 pathway. High expression of LINC-RoR was associated with poorer survival time and multivariate analysis results showed that LINC-RoR was an independent risk factor of tumor malignancy progression. Yes Overexpression of LINC-RoR promoted the cell proliferation and knocked down it can reverse the effect in vitro. 32273727 LINC-ROR LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Regulation(TESC/ALDH1A1/TUBB3/PTEN axis) qRT-PCR//MTT//Colony Formation Assay//Western Blot LncRNA ROR, TESC, ALDH1A1, and TUBB3 were highly expressed in PTC tissues and cells.Overexpression of lncRNA ROR activated TESC by inhibiting the G9a recruitment on the promoter of TESC and histone H3-lysine 9me methylation. Moreover, TESC upregulated ALDH1A1 expression to increase TUBB3 expression, which then reduced PTEN expression. Yes Overexpression of lncRNA ROR, TESC, ALDH1A1 or TUBB3 and silencing of PTEN promoted PTC cell viability, colony formation, migration, and invasion while suppressing apoptosis. Moreover, overexpression of lncRNA ROR increased tumor growth by inhibiting PTEN in vivo. 35173149 LINC-ROR LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells Regulation[miR‑206/VEGF axis] qRT-PCR In the present study, ROR was found to be upregulated and microRNA (miR)‑206 was found to be downregulated in RCC tissues and cells. In summary, the results of the present study revealed that ROR was upregulated in RCC tissues, which promoted tumor progression by regulating the miR‑206/VEGF axis. The present findings provided a novel insight into the potential functions of ROR in RCC, and the ROR/miR‑206/VEGF pathway may be a promising therapeutic target for the treatment of patients with RCC. Yes Furthermore, the knockdown of ROR inhibited the proliferation, migration and invasion of RCC cells. 31485634 LINC-ROR LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Regulation[miR-145/FLNB regulatory axis] Western Blot//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay In our study, we demonstrated that LncRNA-ROR was high expression in ovarian cancer tissues than in normal ovarian tissues.Functionally, LncRNA-ROR could induce epithelial-mesenchymal transition (EMT), and regulated ovarian cancer cell migration and invasion by decreasing the expression of tumor suppressive miR-145 and its target gene FLNB. Moreover, the binding site for miR-145 within LncRNA-ROR contributed to the reciprocal negative regulation of LncRNA-ROR and miR-145. Taken together, LncRNA-ROR promoted EMT by the miR-145/FLNB regulatory axis in ovarian cancer, providing a potential therapeutic target for ovarian cancer. In our study, we demonstrated that LncRNA-ROR was high expression in ovarian cancer tissues than in normal ovarian tissues, and LncRNA-ROR level was positively associated with clinical stages and the differentiation grades of malignant cells. Yes Functionally, LncRNA-ROR could induce epithelial-mesenchymal transition (EMT), and regulated ovarian cancer cell migration and invasion by decreasing the expression of tumor suppressive miR-145 and its target gene FLNB. 31829305 LINC-ROR LncRNA Homo sapiens Osteosarcoma OS tissue Interaction[targeting miR-206] IHC//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Here, we found that ROR expression level was significantly up-regulated in OS tissue samples compared to adjacent normal tissues.In addition, miR-206 was verified to be a target miRNA of ROR using bioinformatics online program and luciferase report assay. miR-206 inhibition partially rescued the inhibitory effects on OS cells induced by ROR knockdown. In conclusion, these results suggested that ROR function as an oncogene in OS by sponging miR-206 and might be a potential therapeutic target for patients with OS. Here, we found that ROR expression level was significantly up-regulated in OS tissue samples compared to adjacent normal tissues, and the elevated ROR was closely correlated with advanced tumour-node-metastasis (TNM) stage and lymph node metastasis and poor overall survival rate. Yes Functional assays showed that ROR knockdown suppressed the OS cell proliferation, colony formation, migration and invasion in vitro, and retarded tumour growth in vivo. 30565392 LINC-ROR LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells regulation[LncRNA-ROR/microRNA-185-3p/YAP1 axis] RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Up-regulated lncRNA-ROR and YAP1 and down-regulated miR-185-3p were found in osteosarcoma.This work illustrates that lncRNA-ROR down-regulation or miR-185-3p up-regulation inhibits osteosarcoma progression via YAP1 repression. Yes LncRNA ROR knockdown or miR-185-3p overexpression inhibited osteosarcoma cell progression while lncRNA ROR elevation or miR-185-3p inhibition presented the opposite effects. 32898639 LINC-ROR LncRNA Homo sapiens Esophageal Neoplasms EC tissues and cells regulation[miR-145/LMNB2 signal axis] Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay ROR and LMNB2 were up-regulated and miR-145 was down-regulated in EC tissues and cells. LMNB2 which is regulated by ROR and miR-145 was highly expressed in EC and promoted the proliferation and migration of EC in vitro and in vivo. Yes The proliferation and migration of EC cells were promoted by overexpression of of ROR or LMNB2. 33312362 LINC-ROR LncRNA Homo sapiens Nasopharyngeal carcinoma serum exosomes Regulation( p-AKT/p-VEGFR2 pathway ) Western Blot//Transfection//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//EdU Staining//Transwell Assay This study demonstrates that linc-ROR is substantially expressed in serum exosomes from NPC and can be taken up by HUVECs. Thus, the p-AKT/p-VEGFR2 pathway is the mechanism by which linc-ROR affects the aforementioned biological activities. By stimulating angiogenesis, linc-ROR appears to play a significant role in the course of NPC and could account for a therapeutic target. Yes Using qRT-PCR, the CCK8 test, the transwell migration assay, the wound healing assay, and the tube formation assay, we demonstrated that linc-ROR increases proliferation, migration, and angiogenesis in vitro. Similar to prior research, our results have shown that linc-ROR can stimulate tumor angiogenesis in the zebrafish model. 36183926 LINC-ROR LncRNA Homo sapiens Glioblastoma cancer stem cell Expression(highly expressed) Transfection//Flow Cytometry//qRT-PCR//RNA-seq//Cell Proliferation Assay Here, we investigated linc-RoR (long intergenic non-protein coding RNA, regulator of reprogramming) using GBM neurospheres obtained from 12 different patients. We demonstrated that the highest level of this transcript is detected in cells with increased EGFR expression. Analysis of RNA sequencing data revealed that linc-RoR affects expression of genes involved in the regulation of mitosis. In agreement with this observation, we have showen that the highest level of linc-RoR is detected in the G2/M phase of the cell cycle, when linc-RoR is localized on the chromosomes of dividing cells. Yes According to our data, linc-RoR knockdown decreases cell proliferation, increases sensitivity to DNA damage, and downregulates the level of cancer stem cell (CSC) markers. On the other hand, linc-RoR overexpression promote cell growth and increases the proportion of CSCs. 35654242 LINC-ROR LncRNA Homo sapiens Glioblastoma GBM tissues and cells Regulation(mTORC2) In Vivo Experiment//Western Blot//qRT-PCR//Cell Proliferation Assay//IHC//EdU Staining We found that LincRNA-RoR was markedly reduced in GBM tissues compared with adjacent non-tumor tissues from 10 cases of GBM patients. Consistently, LincRNA-RoR expression in GBM cells was significantly lower than that in normal glial cells. Mechanistically, LincRNA-RoR inhibited the expression of Rictor, the key component of mTORC2 (mammalian target of rapamycin complex 2), to suppress the activity of Akt pathway and impair the expression of glycolytic effectors, including Glut1, HK2, PKM2 and LDHA. Yes The aerobic glycolysis of GBM cells, as determined by the measurement of glucose uptake and lactate production, was impaired by LincRNA-RoR overexpression. Finally, enforced expression of LincRNA-RoR reduced the proliferation of GBM cells in vitro, restrained tumor growth in vivo, and repressed the expression of glycolytic molecules in GBM xenografts. 29581766 LINC-ROR LncRNA Homo sapiens Retinoblastoma retinoblastoma tissues Interaction(miR-32/H3K27 acetylation ) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//ChIP We showed that lincRNA-ROR was significantly upregulated in retinoblastoma tissues, and overexpression of lincRNA-ROR was significantly correlated with optic nerve invasion, nodal or distant metastasis, and recurrence. Further, we demonstrated that lincRNA-ROR activates the Notch signaling pathway by acting as a sponge of miR-32-5p. Upregulation of lincRNA-ROR was attributed to the CBP-mediated H3K27 acetylation at the promoter region. We showed that lincRNA-ROR was significantly upregulated in retinoblastoma tissues, and overexpression of lincRNA-ROR was significantly correlated with optic nerve invasion, nodal or distant metastasis, and recurrence. Yes We also showed that lincRNA-ROR is a critical promoter of retinoblastoma cell metastasis, both in vivo and in vitro. 32439866 LINC-ROR LncRNA Homo sapiens Endometrial Neoplasms EC tissues regulation[Notch1 pathway] CCK8//qRT-PCR//Tunel//Western Blot Both lncRNA ROR and Notch1 were highly expressed in EC tissues (p<0.05). LncRNA ROR regulates the proliferation and apoptosis of EC cells via promoting the expression of Notch1 protein. Yes After overexpression of lncRNA ROR, HEC-1A cells had significantly enhanced proliferation (p<0.05) and weakened apoptosis (p<0.05). 32572910 LINC-ROR LncRNA Homo sapiens Osteoporosis OP patients Interaction(miR-145-5p axis ) Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay LncRNA ROR was downregulated, and miR-145-5p was overexpressed in OP patients. Luciferase reporting assay verified the target relationship between ROR and miR-145-5p. MiR-145-5p downregulation reversed ROR silence mediated effect on MC3T3-E1 cell proliferation and apoptosis. LncRNA ROR is downregulated and miR-145-5p is highly expressed in OP patient The combined diagnosis of ROR and miR-145-5p showed good diagnostic value for OP. Yes ROR knockdown promoted the MC3T3-E1 cell apoptosis and inhibited cell proliferation. 34617877 lincRNA-01317 LncRNA Homo sapiens Stomach Neoplasms cancer tissue Interaction(KCNQ1) In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//FISH//Cell Viability Assay//Colony Formation Assay//Invasion Assay Here, we found significantly decreased lincRNA-01317 levels in cancer tissue compared with paracancer tissue of patients with gastric cancer, and lincRNA-01317 expression levels positively correlated with clinical survival rate. Finally, we demonstrated that lincRNA-01317 may target KCNQ1, as KCNQ1 was downregulated after transfection of cells with lincRNA-01317. Here, we found significantly decreased lincRNA-01317 levels in cancer tissue compared with paracancer tissue of patients with gastric cancer, and lincRNA-01317 expression levels positively correlated with clinical survival rate. Yes Furthermore, using a gastric cancer cell line and a xenograft mouse model, we found that transfection of a gastric cancer cell line with lincRNA-01317 significantly inhibited the proliferation, migration, and invasion of gastric cancer cells. 33594325 lnc-CHAF1B-3 LncRNA Homo sapiens renal fibrosis human renal proximal tubular cells Expression(highly expressed) Western Blot//Transfection//qRT-PCR//RNA-seq//Microarray Microarray assays showed that expression of the lncRNA lnc-CHAF1B-3 (also called claudin 14 antisense RNA 1) was significantly upregulated in human renal proximal tubular cells by both transforming growth factor-β1 (TGF-β1) and hypoxic stimulation, accompanied with increased expression of EMT-related genes. Yes Knockdown of lnc-CHAF1B-3 significantly suppressed TGF-β1-induced upregulated expression of collagen type I alpha 1, cadherin-2, plasminogen activator inhibitor-1, snail family transcriptional repressor I (SNAI1) and SNAI2. 36700051 lncCIRBIL LncRNA Rattus norvegicus Esophageal Neoplasms Cardiomyocyte Interaction(Bclaf1) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//RIP//IF The level of lncCIRBIL is reduced in I/R hearts. Cardiomyocyte-specific transgenic overexpression of lncCIRBIL reduces infarct area following I/R injury. Knockout of lncCIRBIL in mice exacerbates cardiac I/R injury. Qualitatively, the same results are observed in vitro. LncCIRBIL directly binds to BCL2-associated transcription factor 1 (Bclaf1), to inhibit its nuclear translocation. Cardiomyocyte-specific transgenic overexpression of Bclaf1 worsens, while partial knockout of Bclaf1 mitigates cardiac I/R injury. Meanwhile, partial knockout of Bclaf1 abrogates the detrimental effects of lncCIRBIL knockout on cardiac I/R injury. Yes Knockout of lncCIRBIL in mice exacerbates cardiac I/R injury.Qualitatively, the same results are observed in vitro. LncCIRBIL directly binds to BCL2-associated transcription factor 1 (Bclaf1), to inhibit its nuclear translocation. Cardiomyocyte-specific transgenic overexpression of Bclaf1 worsens, while partial knockout of Bclaf1 mitigates cardiac I/R injury. Meanwhile, partial knockout of Bclaf1 abrogates the detrimental effects of lncCIRBIL knockout on cardiac I/R injury. 33483496 lncCSMD1-1 LncRNA Homo sapiens Carcinoma, Hepatocellular liver tissues regulation[MYC signaling pathway] qRT-PCR//RNA Pull-Down//RIP With microarray, we identified a highly upregulated lncRNA, lncCSMD1-1, which was associated with tumor progression and poor prognosis in the Discovery Cohort, and validated in another 3 HCC cohorts. lncCSMD1-1 is upregulated in HCC and promotes progression of HCC by activating the MYC signaling pathway. Yes Consistently, ectopic expression of lncCSMD1-1 notably promotes cell proliferation, migration, invasion, tumor growth and metastasis of HCC cells in in vitro and in vivo experiments. 32685003 LncRNA-CTS LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues,cell lines(HeLa, SiHa, Ca-Ski, C-33A, and HT-3) Regulation[miR-505/ZEB2 axis] qRT-PCR//Luciferase Report Assay//Transwell Assay//Western Blot Data also showed that lncRNA-CTS could function as a competing endogenous RNA for miR-505 in CC cells. Further investigations disclosed that ZEB2 was demonstrated as a Expression[down-expression]stream target of miR-505, and subsequently exerted its metastatic effects via the lncRNA-CTS/miR-505/ZEB2 axis in CC cells. Finally, lncRNA-CTS activated the SMAD/TGF pathway via miR-505 in CC cells. Collectively, our results demonstrate the importance of the lncRNA-CTS/miR-505/ZEB2 axis in CC. LncRNA-CTS can predispose CC patients to metastases and may represent a promising therapeutic target for CC. The expression levels of lncRNA-CTS and miR-505 were correlated with the metastasis-associated clinicopathological features of CC patients. Moreover, lncRNA-CTS was associated with a poor prognosis in CC patients. Yes In vitro and in vivo experiments, along with gain- and loss-of-function studies, showed that lncRNA-CTS enhanced cell migration, invasion, and the transforming growth factor (TGF)-β1-induced-EMT process. 31499118 lncRNA-CCHE1 LncRNA Homo sapiens Uterine Cervical Neoplasms PTC tissues Expression [highly expressed] Western Blot//Transfection//CCK8//qRT-PCR//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay A higher expression of lncRNA-CCHE1 was found in PTC tissues than in adjacent tissues. High expression of lncRNA-CCHE1 was positively correlated with the number of tumors, extra-glandular invasion, and tumor stage. Yes In addition, the down-regulation of lncRNA-CCHE1 reduced the proliferation and invasion of PTC cell lines and promoted cell apoptosis, while its up-regulation caused the opposite effect. 35116712 lncRNACASC9 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer cells and tissues Interaction(CASC9/miR-195-5p/TK1 axis) qRT-PCR//RNA Pull-Down CASC9 was highly expressed in bladder cancer cells and tissues, and the prognosis of bladder cancer patients with high expression of CASC9 was poor. Mechanistically, through FISH experiments, luciferase reporter experiments, and RIP experiments, we proved that CASC9 regulated the expression of TK1 by adsorbing miR-195-5p, thereby exerting an oncogenic effect in bladder cancer. CASC9 was highly expressed in bladder cancer cells and tissues, and the prognosis of bladder cancer patients with high expression of CASC9 was poor. Yes The results of colony formation assays, CCK-8 assays, EdU assays, transwell assays, mouse xenograft models, and tail vein injection lung metastasis model showed that CASC9 could promote bladder cancer cells growth and metastasis both in vitro and in vivo. 35578597 lncRNA-CASC15 LncRNA Homo sapiens Osteosarcoma clinical samples and OS cells Interaction(Wnt/β-catenin signaling pathway) CCK8//qRT-PCR//Western Blot The results revealed that lncRNA-CASC15 was highly expressed in clinical samples and OS cells. Rescue experiments demonstrated that CASC15 affected the cell cycle by activating the Wnt/β-catenin pathway, thereby promoting cell proliferation. Yes In vitro verification experiments revealed that CASC15 promoted the growth of OS cells. 33760218 lncRNA-ATB LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[activating YAP and increasing ATG5] qRT-PCR//RIP//Western Blot The expression of lncRNA-ATB was higher in HCC tissues than in normal liver tissues. LncRNA-ATB promoted autophagy by activating Yes-associated protein (YAP). Moreover, lncRNA-ATB interacted with autophagy-related protein 5 (ATG5) mRNA and increased ATG5 expression. lncRNA-ATB expression was positively correlated with tumor size, TNM stage, and poorer survival of patients with HCC. Yes Moreover, ectopic overexpression of lncRNA-ATB promoted cell proliferation and clonogenicnity of HCC cells in vitro. 31558875 lncRNA-ATB LncRNA Homo sapiens Liver Neoplasms HBV-related liver cancer and non-HBV infected liver cancer tissues Interaction[TGF‑β ] qRT-PCR//Western Blot These results suggested that increased expression of lncRNA-ATB in primary liver cancer may be associated with HBV infection and advanced tumor development.Bx‑induced autophagy could upregulate the expression of TGF‑β and lncRNA‑ATB. Mechanistically, PGM5-AS1 was transcriptionally activated by p53 and it could directly interact with and sequester miR-466 to elevate PTEN expression, thereby inhibiting ESCC progression. Yes In addition, the invasive and migration abilities of HBx‑HepG2 cells were increased compared with HepG2 cells, while knockdown of lncRNA‑ATB or TGF‑β could reduce these abilities. 31746419 lncRNA-ANRIL LncRNA Homo sapiens Glioma 142 glioma patients Interaction(SOX9 ) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay ANRIL and SOX9 were evidently higher in RG than in CG (P<0.01).The receiver operating characteristic (ROC) curve revealed that the diagnostic sensitivity of ANRIL combined with SOX9 for glioma was 81.62%, and the specificity was 90.83% (P<0.01). ANRIL and SOX9 were closely related to tumor grade, tumor diameter, distant metastasis, and family history of glioma (P<0.01).ANRIL and SOX9 were markedly higher in glioma cell lines (U251 and U87) than in normal brain cells (P<0.01). Bcl-2 expression was markedly increased in lncRNA-ANRIL-inhibitor and SOX9-inhibitor (P<0.01), while bax expression was markedly reduced in lncRNA-ANRIL-inhibitor and SOX9-inhibitor (P<0.01). The receiver operating characteristic (ROC) curve revealed that the diagnostic sensitivity of ANRIL combined with SOX9 for glioma was 81.62%, and the specificity was 90.83% (P<0.01). ANRIL and SOX9 were closely related to tumor grade, tumor diameter, distant metastasis, and family history of glioma (P<0.01). Yes The proliferation and invasion of U251 cells were notably reduced after the transfection of ANRIL and SOX9 inhibitory sequences (P<0.01), but the apoptosis was notably increased (P<0.01). 34556140 lncRNA-AK001903 LncRNA Homo sapiens Uterine Cervical Neoplasms Cervical cancer (CC) tissues and cell lines(Hela, Siha, Ca Ski, C33a, H8) Expression [highly expressed] ISH//CCK8//qPCR//Transwell Assay In the present study, lncRNA microarrays were conducted to investigate the differentially expression lncRNAs in cervical cancer (CC) tissues compared with peritumoral tissues. Then, the most significantly upregulated lncRNA, which was lncRNA-AK001903 was selected to conduct further experiments. Real-time Quantitative polymerase chain reaction was conducted to investigate lncRNA-AK001903 expression in CC tissues and Hela, Siha, Ca Ski, C33a, H8 (HPV-immortalized cervical epithelial cell line) cell lines, and in situ hybridization histochemistry (ISHH) was performed to detect lncRNA-AK001903 expression level in different CC stages. The effect of lncRNA-AK001903 on cell proliferation, invasion and migration was assessed after knockdown of lncRNA-AK001903. LncRNA-AK001903 is upregulated in CC tissues and cells and related to FIGO stage in patients with CC Among the 20 most significantly differentially expressed lncRNAs (DE lncRNAs) in the CC tissues vs. CP (peritumoral tissues), the most notably upregulated one was lncRNA-AK001903. Yes The effect of lncRNA-AK001903 on cell proliferation, invasion and migration was assessed after knockdown of lncRNA-AK001903. 33363614 LncRNAAirsci LncRNA Rattus norvegicus Spinal Cord Injuries SCI rats Regulation In Vivo Experiment//Western Blot//qRT-PCR//RNA-seq//Bioinformatics Analysis LncRNA Airsci was the most significantly expressed among the five lncRNAs involved in the NF-κB signaling pathway. LncRNA Airsci-siRNA reduced the inflammatory response by inhibiting the NF-κB signaling pathway, alleviated spinal cord tissue injury, and promoted the recovery of motor function in SCI rats. Yes LncRNA Airsci-siRNA reduced the inflammatory response by inhibiting the NF-κB signaling pathway, alleviated spinal cord tissue injury, and promoted the recovery of motor function in SCI rats. 33063741 LncRNA-Airn LncRNA Homo sapiens Acute Liver Injury liver tissue and primary hepatocytes Regulation(p65 and IκBα) Western Blot//Transfection//Tunel//qRT-PCR//Luciferase Report Assay//H&E Staining In this study, we show that Airn is upregulated in liver tissue and primary hepatocytes from an acute liver injury mouse model. Consistently, Airn is also overexpressed in serum samples of patients with acute-on-chronic liver failure and is negatively correlated with the Model for End-Stage Liver Disease (MELD) score. Mechanistically, we reveal that Airn represses CCl 4- and H 2O 2-induced enhancement of phosphorylation of p65 and IκBα, suggesting that Airn inhibits hepatocyte apoptosis by inactivating the NF-κB pathway. Yes Moreover, gene knockout and rescue assays reveal that Airn alleviates CCl 4-induced liver injury by inhibiting hepatocyte apoptosis and oxidative stress in vivo. Further investigation reveals that Airn decreases H 2O 2-induced hepatocyte apoptosis in vitro. 36604144 lncRNA-ABHD11-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary serum of PTC patients Expression [highly expressed] qRT-PCR According to the data, the expression levels of serum ABHD11-AS1 in the PTC patients were remarkably higher than those in the healthy controls, and the area under the curve (AUC) for distinguishing the patients from the controls was 0.920. In the analysis of prognosis, the levels in patients with a poor prognosis were remarkably higher than those in patients with a good prognosis. Yes In the cell experiments, knocking down ABHD11-AS1 remarkably inhibited PTC cells from proliferation, arrested them in G0/G1 phase, and induced their apoptosis, negatively affecting their survival indices. Overexpressing this RNA had positive effects on the survival indices. 34102210 lncRNA93358 LncRNA Rattus norvegicus Myocardial Infarction model rats Regulation(SLC8A1) In Vivo Experiment//Western Blot//Tunel//qRT-PCR//Luciferase Report Assay//H&E Staining lncRNA 93358 and Bax were found significantly upregulated, and Bcl-2 and SLC8A1 were greatly downregulated in model rats, which were dramatically reversed by the knockdown of lncRNA 93358, accompanied by the decline area of myocardial necrosis and decreased apoptotic myocardial cells. Yes lncRNA 93358 and Bax were found significantly upregulated, and Bcl-2 and SLC8A1 were greatly downregulated in model rats, which were dramatically reversed by the knockdown of lncRNA 93358, accompanied by the decline area of myocardial necrosis and decreased apoptotic myocardial cells. 35845941 LncRNA-6395 LncRNA Mus musculus Myocardial Reperfusion Injury infarct area of mouse hearts and NMVCs Interaction(p53) Other We showed that lncRNA KnowTID_00006395, termed lncRNA-6395 was significantly upregulated in the infarct area of mouse hearts following I/R injury as well as in H2O2-treated neonatal mouse ventricular cardiomyocytes (NMVCs). We demonstrated that lncRNA-6395 directly bound to p53, and increased the abundance of p53 protein through inhibiting ubiquitination-mediated p53 degradation and thereby facilitated p53 translocation to the nucleus. More importantly, overexpression of p53 canceled the inhibitory effects of lncRNA-6395 knockdown on cardiomyocyte apoptosis, whereas knockdown of p53 counteracted the apoptotic effects of lncRNA-6395 in cardiomyocytes. Yes Overexpression of lncRNA-6395 led to cell apoptosis and the expression change of apoptosis-related proteins in NMVCs, whereas knockdown of lncRNA-6395 attenuated H2O2-induced cell apoptosis. LncRNA-6395 knockout mice (lncRNA-6395+/-) displayed improved cardiac function, decreased plasma LDH activity and infarct size following I/R injury. 34493812 LncRNA-5657 LncRNA Rattus norvegicus Brain Injuries glial cells and rat models of septic encephalopathy Regulation In Vivo Experiment//Western Blot//Transfection//qRT-PCR//H&E Staining//ELISA//IHC The sh-LncRNA-5657 treatment reduced the level of neuronal degeneration and necrosis in the rat hippocampus, reduced the immunoreactivities of aquaporin 4, heparanase, and metallopeptidase-9, and lowered the level of tumor necrosis factor-alpha. These findings suggested that LncRNA-5657 expression can significantly reduce the inflammatory reaction during septic encephalopathy and induce protective effects against this disease. Yes The sh-LncRNA-5657 treatment reduced the level of neuronal degeneration and necrosis in the rat hippocampus, reduced the immunoreactivities of aquaporin 4, heparanase, and metallopeptidase-9, and lowered the level of tumor necrosis factor-alpha. Sh-LncRNA-5657 transfection decreased the expression of LncRNA-5657 in lipopolysaccharide-treated glial cells and decreased the mRNA and protein levels of tumor necrosis factor-alpha, interleukin-1β, and interleukin-6. 33318407 lncRNA-45 LncRNA Homo sapiens Breast Neoplasms 4T1-LG12 cells Expression(highly expressed) Western Blot//Wound Healing Assay//Tunel//Migration Assay//qRT-PCR//RNA-seq//Invasion Assay//Transwell Assay We found that many differently expressed lncRNAs greatly correlated to the metastatic propensity of 4T1-LG12 cells, particularly lncRNA-45, a new lncRNA without functional annotations, which was found to be the most upregulated lncRNA transcribed by an internal region within the regulatory associated with protein of mechanistic target of rapamycin kinase (mTOR) complex 1 (Rptor) gene.Molecular mechanistic investigation showed that reduced activity of mTORC1-associated pathway led to a decrease of total ribosomal protein S6 kinase, polypeptide 1 (S6K1) content and enhancement of autophagy, consequently compromising the metastatic propensity in lncRNA-45 knockdown cells. Yes LncRNA-45 was uncovered to be involved in the epithelial-to-mesenchymal transition process of breast cancer cells, as evidenced by the observation that lncRNA-45 knockdown significantly suppressed the invasive capability of parental 4T1-LG12 cells. 36502630 LncRNA4344 LncRNA Rattus norvegicus Cognitive Dysfunction hippocampal tissues of LPS-treated rats and RM cells Interaction( miR-138-5p) In Vivo Experiment//Western Blot//Tunel//qRT-PCR//Cell Apoptosis Assay//ELISA//Bioinformatics Analysis The expression levels of lncRNA 4344 and NLRP3 were upregulated in the hippocampal tissues of LPS-treated rats and RM cells, and showed a strong positive correlation between each other. Subsequently, the results of the animal experiments showed that the lncRNA 4344/miR-138-5p/NLRP3 axis plays an essential role in regulating the cognitive behavior, pathological changes and apoptosis of hippocampal neurons, expression of inflammation-related factors (NLRP3, caspase-1, IL-1β, and IL-18), and microglial activation in LPS-induced cognitive impairment rats. Yes LncRNA 4344 overexpression further enhanced the expression of NLRP3 and its downstream genes (caspase-1, IL-1β, and IL-18), as well as neuronal apoptosis in LPS-stimulated RM cells, whereas lncRNA 4344 silencing attenuated the inflammatory injuries. 34455059 lncRNA‐422 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissue and cell line Interaction(SFPQ) qRT-PCR Mechanistically, lncRNA‐422 could interact directly with splicing factor proline and glutamine rich (SFPQ) to activate downstream pathways. SFPQ drives cancer progression through diverse roles in RNA transcriptional activity, mRNA processing, splicing regulation and innate immune response in hepatocellular carcinoma, 1 breast cancer, 2 ovarian cancer 3 and colorectal cancer. 4 Moreover, SFPQ promoted the proliferation and onset of colorectal cancer. Yes In this study, the biological function of lncRNA‐422 was investigated in colorectal cancer, which suggested that down‐regulated lncRNA‐422 suppressed cell proliferation and inhibited tumor growth in cellular and xenograft models. 35075799 lnc-RAB11B-AS1 LncRNA Homo sapiens Lung Neoplasms LC tissues Expression[highly expressed] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The results showed that lnc-RAB11B-AS1 was significantly overexpressed in LC tissues compared to the corresponding non-tumor tissues. Patients with a higher level of lnc-RAB11B-AS1 expression showed a poorer overall survival rate. Yes Functionally, overexpression of lnc-RAB11B-AS1 promotes cell proliferation, migration and invasion abilities of LC cell lines, which suggests lnc-RAB11B-AS1 may play an oncogenic role in LC. 32566609 LNCPOIR LncRNA Homo sapiens Epithelial-Mesenchymal Transition HCC cells Interaction(miR-182-5p) Cell Proliferation Assay//qRT-PCR//Transfection//Luciferase Report Assay Together, these pieces of data suggest that lncRNA-POIR promotes EMT progression and suppresses SOR sensitivity simultaneously by sponging miR-182-5p. Yes Furthermore, loss- or gain-of-function approaches were used to demonstrate the role of lncRNA-POIR/miR-182-5p on EMT and SOR sensitivity in HCC. 32951268 lnc-PKMYT1AR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Interaction(miR-485-5p/PKMYT1 axis) Migration Assay//CCK8//Flow Cytometry//qRT-PCR//IP//Colony Formation Assay Here, we identify a human-specific long non-coding RNA (lncRNA, ENST00000595422), termed PKMYT1AR (PKMYT1 associated lncRNA), that is induced in NSCLC by Yin Yang 1 (YY1) factor, especially in cancerous cell lines (H358, H1975, H1299, H1650, A549 and SPC-A1) compared to that in normal human bronchial epithelium cell line (BEAS-2B). Bioinformatic analysis and a luciferase assay demonstrate that PKMYT1AR directly interacts with miR-485-5p to attenuate the inhibitory role on its downstream oncogenic factor PKMYT1 (the protein kinase, membrane-associated tyrosine/threonine 1) in NSCLC. We show that PKMYT1AR high expression correlates with worse clinical outcome, and knockdown of PKMYT1AR inhibits tumor cell proliferation, migration and xenograft tumor formation abilities.  Yes We show that PKMYT1AR high expression correlates with worse clinical outcome, and knockdown of PKMYT1AR inhibits tumor cell proliferation, migration and xenograft tumor formation abilities. 34856993 lncRNA-CCRR LncRNA Homo sapiens Breast Neoplasms 64 breast cancer patients Interaction(CX43) qRT-PCR//IHC//Western Blot Compared with the non-metastasis group, the mRNA expression of tissue lncRNA-CCRR, cerebrospinal fluid (CSF) lncRNA-CCRR, tissue CX43 and tissue protein expression of CX43 were both evidently up-regulated in metastasis patients, especially in patients with brain metastasis.The expression of lncRNA-CCRR was positively correlated with the up-regulated expression of CX43. Yes Also, the overexpression of lncRNA-CCRR evidently increased dye transfer rate from astrocytes to MDA-MB-231BR/BT-474BR cells but reduced lncRNA-CCRR expression and suppressed the transmigration of MDA-MB-231BR/BT-474BR cells in a blood-brain barrier (BBB) model.  33793070 lncRNA-DANCR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed ] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay The expression of lncRNA-DANCR in CRC tissues and HT-29 cells was significantly higher than that in non-CRC tissues and FHC cells. Yes Silencing lncRNA-DANCR could significantly inhibit the proliferation, invasion and metastasis of HT-29 cells. Western blot showed that the expression of E-cadherin increased significantly and vimentin decreased significantly after silencing lncRNA-DANCR. The same results were observed in immunofluorescence experiment. Silence of lncRNA-DANCR markedly sExpression[Expression[up-expression]-expression]pressed the growth and metastasis of CRC. 35117008 lnc-CTSLP4 LncRNA Homo sapiens Stomach Neoplasms GC tumor tissues Interaction(Hsp90α and recruiting E3 ubiquitin ligase ZFP91/HNRNPAB-dependent Snail transcription) In Vivo Experiment//RNA Pull-Down//Western Blot//Co-IP//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//IP//IHC//Invasion Assay//ChIP We found that lnc-CTSLP4 was significantly downregulated in GC tumor tissues compared with adjacent non-tumor tissues, and its levels in GC tumor tissues were closely correlated with tumor local invasion, TNM stage, lymph node metastasis, and prognosis of GC patients. Mechanistic analysis demonstrated that lnc-CTSLP4 could bind with Hsp90α/heterogeneous nuclear ribonucleoprotein AB (HNRNPAB) complex and recruit E3-ubiquitin ligase ZFP91 to induce the degradation of HNRNPAB, thus suppressing the transcriptional activation of Snail and ultimately reversing EMT of GC cells. We found that lnc-CTSLP4 was significantly downregulated in GC tumor tissues compared with adjacent non-tumor tissues, and its levels in GC tumor tissues were closely correlated with tumor local invasion, TNM stage, lymph node metastasis, and prognosis of GC patients. Yes Loss- and gain-of-function assays indicated that lnc-CTSLP4 inhibited GC cell migration, invasion, and EMT in vitro, as well as peritoneal dissemination in vivo. 33717650 lncRNA-DAW LncRNA Homo sapiens Liver Neoplasms hepatocellular carcinoma (HCC) specimens Interaction(EZH2/Wnt2/Wnt/β-catenin pathway) In Vivo Experiment//Western Blot//Co-IP//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//ChIP Our results revealed that lncRNA-DAW was driven by a liver-specific super-enhancer and transcriptionally activated by HNF4G, leading to frequent elevation in hepatocellular carcinoma (HCC) specimens. By using RNA sequencing, Wnt2 was screened out as a downstream effector of lncRNA-DAW. We next found that lncRNA-DAW physically interacted with EZH2, a negative regulator of Wnt2. This interplay subsequently potentiated CDK1-EZH2 interaction, leading to the phosphorylation and ubiquitination of EZH2. Yes Ectopic expression of lncRNA-DAW promoted both in vivo and in vitro tumor growth. 34853732 LncRNA-ZXF1 LncRNA Mus musculus endometrial endometrioid adenocarcinoma, secretory variant (EEC) cells Interaction(miR-378a-3p/PCDHA3 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Transfection//qRT-PCR//RIP//migration assay//Luciferase Report Assay//IP//IHC This regulation may be achieved by the lncRNA-ZXF1-mediated alteration in the expression of P21 through two mechanisms. One is that lncRNA-ZXF1 functions as a molecular sponge of miR-378a-3p to regulate PCDHA3 expression and then modulate the expression of P21. The other is that lncRNA-ZXF1 inhibits CDC20-mediated degradation of ubiquitination by directly binding to P21. Yes We found that lncRNA-ZXF1 altered the migration and invasion of endometrioid endometrial cancer (EEC) cells. Furthermore, our results suggest that lncRNA-ZXF1 regulates EEC cell proliferation. 33751805 LncRNA-UCA1 LncRNA Homo sapiens Adenocarcinoma of Lung tumor tissues and cells Interaction( miR-383/VEGFA) In Vivo Experiment//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Colony Formation Assay//Transwell Assay The expression of lncRNA-UCA1 was significantly increased in tumor tissues and cells compared with adjacent tissues or HBE cells. Silencing lncRNA-UCA1 expression in cells resulted in a reduction in lung cancer cell viability. Yes Silencing lncRNA-UCA1 expression in cells resulted in a reduction in lung cancer cell viability. 35980157 lncRNA-u50535 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues,cell line( HBE,A549, H1299 and SPC-A1) Regulation[CCL20/ERK signaling] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results demonstrated that lncRNA‑u50535 expression was Expression[Expression[up-expression]-expression]regulated in lung cancer tissues and cell lines compared with normal tissues and cells.Western blot and luciferase reporter gene assays demonstrated that lncRNA‑u50535 overexpression increased the translation and transcription of CCL20. In addition, knockExpression[down-expression] of lncRNA‑u50535 decreased CCL20, CCR6 and p‑ERK levels. The effects of lncRNA‑u50535 on cell proliferation and cell apoptosis were weakened when CCL20 was silenced. Yes KnockExpression[down-expression] of lncRNA‑u50535 decreased lung cancer cell proliferation and migration, induced G0/G1 phase arrest and promoted cell apoptosis. 31545478 lncRNA-SRA LncRNA Homo sapiens Cardiovascular Diseases blood Expression[Expression[lower expressed]-expression] qRT-PCR//MTT The clinicopathological features of these patients are summarized in Table I. As presented in Fig. 1, the plasma levels of lncRNA-SRA were significantly decreased in patients with type II diabetic cardiovascular disease compared with type II diabetic patients without any obvious complications and healthy controls (P<0.05). A total of 172 type II diabetic patients without any obvious complications on the day of admission completed the 5-year follow-Expression[Expression[up-expression]-expression]. According to the median relative plasma level of lncRNA-SRA (1.44), these patients were divided into a high (n=86) and a low (n=86) expression groExpression[Expression[up-expression]-expression]. During the follow-Expression[Expression[up-expression]-expression], cardiovascular disease occurred in 41 cases, including 29 cases in the low expression groExpression[Expression[up-expression]-expression] and 12 cases in the high expression groExpression[Expression[up-expression]-expression]. As presented in Fig. 3, the incidence of cardiovascular disease was significantly higher in the low expression groExpression[Expression[up-expression]-expression] compared with that in the high expression groExpression[Expression[up-expression]-expression] (P<0.05). Yes In addition, lncRNA-SRA overexpression significantly increased the viability of VSMCs compared with the untransfected control cells and negative control-transfected cells in the presence of D-glucose, but not in the absence of glucose (P<0.05; Fig. 5B). 30988713 lncRNASNHG1 LncRNA Mus musculus Breast Neoplasms cell lines Expression [highly expressed] qRT-PCR//FISH Here we reported that lncRNA SNHG1 functioned as a modulator of M2 macrophage polarization and regulated tumor growth and angiogenesis. We indicated that knockdown of SNHG1 inhibited M2 macrophage polarization by suppression of STAT6 phosphorylation. Yes We indicated that knockdown of SNHG1 inhibited M2 macrophage polarization by suppression of STAT6 phosphorylation. 34618681 lncRNASLC26A4‐AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Regulation( ETS1 to promote ITPR1‐mediated autophagy) qRT-PCR//RIP//Luciferase Report Assay//IHC//ChIP Then, Western blot and RT‐qPCR were conducted to determine the expression of ITPR1 and SLC26A4‐AS1 in PTC tissues and cells, both of which were found to be poorly expressed in PTC tissues and cells. In conclusion, our study elucidated that SLC26A4‐AS1 overexpression promoted ITPR1 expression through recruiting ETS1 and thereby promotes autophagy, alleviating PTC progression. Yes Then, we constructed ITPR1‐overexpressing cells and revealed that ITPR1 overexpression could trigger the autophagy of PTC cells. Further, we performed a series of gain‐ and loss‐of function experiments. The results suggested that silencing of SLC26A4‐AS1 led to declined ITPR1 level, up‐regulation of ETS1 promoted ITPR1 expression, and either ETS1 knockdown or autophagy inhibitor Bafilomycin A1 could mitigate the promoting effects of SLC26A4‐AS1 overexpression on PTC cell autophagy. In vivo experiments also revealed that SLC26A4‐AS1 overexpression suppressed PTC tumour growth. 34378314 LncRNA-ROR LncRNA Homo sapiens Osteosarcoma Fifty-one patients with the first diagnosis of osteosarcoma Interaction(microRNA-185-3p/YAP1 axis) qRT-PCR//MTT//Colony Formation Assay//Transwell Assay Up-regulated lncRNA-ROR and YAP1 and down-regulated miR-185-3p were found in osteosarcoma. Function of lncRNA ROR was rescued by miR-185-3p and regulated the growth and metastasis of osteosarcoma cells via modulating YAP1, the target gene of miR-185-3p. Yes LncRNA ROR knockdown or miR-185-3p overexpression inhibited osteosarcoma cell progression while lncRNA ROR elevation or miR-185-3p inhibition presented the opposite effects. 32898639 lncRNARAMS11 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissue samples Interaction(CBX4/Top2α axis) Western Blot//qRT-PCR//RIP//Microarray//Transwell Assay The expression of lncRNA RAMS11 was up-regulated in prostate cancer tissue samples. We also demonstrated that lncRNA RAMS11 bound to CBX4 to activate expression of Top2α. Yes LncRNA RAMS11 promoted cell growth and metastasis of prostate cancer cells. Down-regulation of lncRNA RAMS11 attenuated cell growth and metastasis of prostate cancer cells. 33564266 LncRNA-PVT1 LncRNA Homo sapiens Glioma glioma patients Interaction(miR-1207-3p/HNF1B signaling axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Microarray//Cell Proliferation Assay//IHC//Transwell Assay Our data showed that the expression of lncRNA-PVT1 was increased obviously and associated with advanced tumor stage, metastasis, invasion ability, and poor prognosis in glioma patients.Online software (TargetScan, miRDB and miR TarBase) were used to predict the regulating mechanisms of lncRNA-PVT1, miR-1207-3p and HNF1B, which were validated by dual-luciferase reporter gene system. Therefore, we suggested that lncRNA-PVT1/miR-1207-3p/HNF1B axis might play critical roles in glioma progression, indicating that lncRNA-PVT1/miR-1207-3p/HNF1B signaling axis may serve as novel molecular targets for glioma prevention and treatment. Our data showed that the expression of lncRNA-PVT1 was increased obviously and associated with advanced tumor stage, metastasis, invasion ability, and poor prognosis in glioma patients. Yes Up-regulation of lncRNA-PVT1 was observed to promote glioma cells proliferation, and invasion abilities in vitro as well as tumor growth in vivo by regulating miR-1207-3p expression. In vivo tumor-bearing mice models were established to validate the cellular results. 34475987 lncRNA-PACER LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(COX-2) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qPCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay RT-qPCR analysis revealed that PACER was highly expressed in CRC tissues and cells, and a high PACER-expression level was associated with poor prognosis. RT-qPCR showed that PACER increased mRNA levels of COX-2. Luciferase assay revealed that PACER modulated the COX-2 promoter region. Mouse xenograft models of CRC revealed that PACER promoted colorectal tumorigenesis in vivo. ELISA revealed that PACER knock-down inhibited PGE2 production. RT-qPCR analysis revealed that PACER was highly expressed in CRC tissues and cells, and a high PACER-expression level was associated with poor prognosis. Yes MTT assay, wound-healing assay, colony-formation assay, and transwell assay revealed that PACER enhanced CRC-cell proliferation, invasion, and metastasis in vitro. 34316376 LncRNA-p21 LncRNA Homo sapiens Stomach Neoplasms GC cell line Interaction(miR-514b-3p/ARHGEF9 pathway) Luciferase Report Assay//Bioinformatics Analysis LncRNA-p21 overexpression in GC cell line somatic gastric cancer (SGC)-7901 and human gastric cancer (HGC)-27 suppressed cell proliferation and enhanced apoptosis, while lncRNA-p21 knockdown caused the opposite effects. Our study reveals a novel lncRNA-p21/miR-514b-3p/ARHGEF9 pathway that can be targeted for GC therapy. Yes LncRNA-p21 overexpression in GC cell line somatic gastric cancer (SGC)-7901 and human gastric cancer (HGC)-27 suppressed cell proliferation and enhanced apoptosis, while lncRNA-p21 knockdown caused the opposite effects. 35947460 LncRNA-MSC-AS1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cells Interaction(miR-425-5p) qRT-PCR//MTT//Luciferase Report Assay//Tunel MSC-AS1 expression level was lowly expressed, while miR-425-5p level was highly in ovarian cancer tissues and cells. Moreover, MSC-AS1 targeted and negatively modulated miR-425-5p. MiR-425-5p up-regulation has been proved to partially reverse the tumor suppressive function of MSC-AS1 overexpression Yes Elevation of MSC-AS1 has the ability to significantly inhibit cell proliferation and facilitate cell apoptosis in SKOV3 and A2780 cells. 34454554 LncRNAMORT LncRNA Mus musculus Myocardial Infarction plasma and heart tissues regulation[downregulating miR-93] qRT-PCR In the present study we found that MORT expression levels were higher, while expression levels of miR-93 were lower in both plasma and heart tissues of mice MI mice models compared with Sham mice. Therefore, lncRNA MORT is upregulated in myocardial infarction and promotes the apoptosis of cardiomyocyte by downregulating miR-93. Yes MORT overexpression promoted cardiomyocyte apoptosis, while miR-93 overexpression played and opposite role and attenuated the effects of MORT overexpression. 32450811 LncRNA-KAT7 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-10a) Cell Proliferation Assay//qRT-PCR//Transfection The results showed that KAT7 was downregulated in NSCLC and predicted poor survival. KAT7 negatively correlated with miR-10a in NSCLC. In NSCLC cells, overexpression of KAT7 led to downregulated miR-10a, whereas silencing of KAT7 led to upregulated miR-10a. Methylation-specific polymerase chain reaction revealed that KAT7 positively regulated the methylation of miR-10a. The results showed that KAT7 was downregulated in NSCLC and predicted poor survival. Yes Cell proliferation assay showed that overexpression of miR-10a led to increased proliferation rate of NSCLC cells. In addition, overexpression of KAT7 played an opposite role and reduced the effects of the overexpression of miR-10a. 32423237 LncRNA-IMAT1 LncRNA Homo sapiens Meningioma meningioma cell Interaction(KLF4/hsa-miR22-3p/Snai1 Pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay Our studies indicated that IMAT1 was highly expressed in invasive meningiomas compared with non-invasive meningiomas. In vitro studies showed that IMAT1 promoted meningioma cell invasion through the inactivation of the Krüppel-like factor 4 (KLF4)/hsa-miR22-3p/Snai1 pathway by acting as a sponge for hsa-miR22-3p, and IMAT1 knockdown effectively restored the tumor suppressive properties of KLF4 by preserving its tumor suppressor pathway. Yes In vitro studies showed that IMAT1 promoted meningioma cell invasion through the inactivation of the Krüppel-like factor 4 (KLF4)/hsa-miR22-3p/Snai1 pathway by acting as a sponge for hsa-miR22-3p, and IMAT1 knockdown effectively restored the tumor suppressive properties of KLF4 by preserving its tumor suppressor pathway. In vivo experiments confirmed that IMAT1 silencing could significantly inhibit the growth of subcutaneous tumors and prolong the survival period of tumor-bearing mice. 35680373 LncRNA-HCG18 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Interaction(miR-106a-5p/PPP2R2A) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay It was found that HCG18 was down-regulated in PTC.HCG18 interacted with miR-106a-5p, the expression of which was upregulated in PTC. Upregulating miR-106a-5p expression by lentivirus infection promoted viability, migration and invasion and inhibited apoptosis of PTC cells, reversed the effect of HCG18 on the biological behaviors of PTC cells, and promoted the expressions of MMP-2, MMP-9, E-cadherin, and Vimentin and downregulated E-cadherin expression in PTC cells. PPP2R2A, a direct target of miR-106a-5p, was downregulated in PTC, and HCG18 promoted PPP2R2A expression in PTC cells by sponging miR-106a-5p. Yes Overexpressing HCG18 suppressed viability, migration, and invasion, promoted apoptosis, and inhibited miR-106a-5p expression in PTC cells. 33798913 LncRNA-HAGLR LncRNA Homo sapiens Breast Neoplasms TNBC tissues and cell lines Interaction(miR-335-3p/WNT2 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay HAGLR was increased in TNBC tissues and cell lines. Furthermore, HAGLR acted as a sponge of miR-335-3p and inhibited its expression. And miR-335-3p directly targeted WNT2. Yes Silencing of HAGLR inhibited viability, proliferation, migration, and invasion of BT549 cells. Functionally, forced expression of miR-335-3p or knockdown of WNT2 removed the promoted effects of lncRNA HAGLR on TNBC development. In vivo tumorigenesis experiments indicated HAGLR accelerated tumor growth via miR-335-3p/WNT2 axis. 34375306 LncRNA-H19 LncRNA Homo sapiens Glioma U251 and U87-MG cells Regulation In Vivo Experiment//Wound Healing Assay//Migration Assay//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Transwell Assay Knocking down lncRNA-H19 gene could effectively suppress the proliferation of U251 and U87-MG cells. The knockdown of lncRNA-H19 remarkably inhibited the migration and blocked cycle progressions of U251 and U87-MG cells, yet, no obvious changes were observed in cell apoptosis. Besides, inhibiting lncRNA-H19 expression could attenuate sphere-forming function of U251 and U87-MG cells. Yes Knocking down lncRNA-H19 gene could effectively suppress the proliferation of U251 and U87-MG cells. The knockdown of lncRNA-H19 remarkably inhibited the migration and blocked cycle progressions of U251 and U87-MG cells. 34477331 lncRNA-FTX LncRNA Homo sapiens Pancreatic Neoplasms PC cell lines Interaction(miR-513b-5p) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Cell Cycle Assay//Invasion Assay The expression levels of FTX were increased in PC cell lines, and silencing of FTX remarkably suppressed the invasion ability and cell viability. Besides, FTX could bind to miR-513b-5p as a competitive endogenous RNA, thus promoting the invasion and proliferation ability of PC cells. Yes silencing of FTX remarkably suppressed the invasion ability and cell viability. Moreover, knockdown of FTX inhibited the tumor growth and increased the expression levels of miR-513b-5p and apoptosis-related proteins in vivo. 33736615 lnc-PKD2-2-3 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues, CCA cell lines Interaction(Lnc-PKD2-2-3/miR-328/GPAM ) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay Lnc-PKD2-2-3 and GPAM were higher, whereas miR-328 was lower in CCA tissues versus adjacent tissues and also in CCA cell lines versus control cells; meanwhile, they were correlated with each other (all P <0.05). MiR-328 knockdown induced CCA cell proliferation and invasion and also attenuated the effect of lnc-PKD2-2-3-knockdown in these functions (all P <0.05). Subsequently, GPAM knockdown reduced CCA cell proliferation and invasion and also weakened the effect of miR-328-knockdown in these functions (all P <0.05). Additionally, lnc-PKD2-2-3 positively regulated GPAM while negatively regulating miR-328. MiR-328 negatively modified GPAM in CCA cells. Luciferase gene reporter assays verified that lnc-PKD2-2-3 directly bound miR-328 and miR-328 directly bound GPAM. Finally, the lnc-PKD2-2-3/miR-328/GPAM network also regulated the 5-FU chemosensitivity of CCA cells. Yes Lnc-PKD2-2-3 knockdown decreased CCA cell proliferation, invasion, and increased apoptosis (all P <0.05), but lnc-PKD2-2-3 overexpression exhibited the opposite and weaker effect. In vivo experiments further revealed that lnc-PKD2-2-3 overexpression promoted tumor volume and weight but repressed tumor apoptosis in xenograft mice; meanwhile, it increased GPAM expression but decreased miR-328 expression (all P <0.05). Conversely, lnc-PKD2-2-3 knockdown exhibited the opposite effects (all P <0.05). 35965521 lncPENG LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues interaction[PDZK1,miR-15b] RNA Pull-Down//Western Blot//ISH//CCK8//qRT-PCR//FISH//RIP//Colony Formation Assay Conversely, a novel lncRNA (lncPENG) was expressed at a lower level in ccRCC tissues, and its downregulation was associated with the same effects as upregulation of miR-15b.Thus, lncPENG may function as a ceRNA to attenuate miR-15b-dependent PDZK1 downregulation and inhibit cell proliferation, suggesting that it may be clinically valuable as a therapeutic target and a prognostic biomarker of ccRCC. Yes Downregulation of miR-15b and upregulation of lncPENG resulted in a significant increase in PDZK1 level and inhibition of proliferation in vitro and in vivo. 32341409 lnc-PCIR LncRNA Homo sapiens Triple Negative Breast Neoplasms TCGA(One hundred and ten paired TNBC and neighboring noncancerous tissues) Interaction(TAB3 and PABPC4) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//Invasion Assay Here, we report a lncRNA RP11-214F16.8, which renamed Lnc-PCIR, is upregulated and higher RNA level of Lnc-PCIR was positively correlated to the poor survival of patients with triple negative breast cancer (TNBC) tissues. Mechanistically, higher Lnc-PCIR level of blocks PABPC4 proteasome-dependent ubiquitination degradation; stable and highly expressed PABPC4 can further increase the stability of TAB3 Mrna. Here, we report a lncRNA RP11-214F16.8, which renamed Lnc-PCIR, is upregulated and higher RNA level of Lnc-PCIR was positively correlated to the poor survival of patients with triple negative breast cancer (TNBC) tissues. Yes Lnc-PCIR overexpression significantly promoted cell proliferation, migration, and invasion in vitro and in vivo. 34012913 LNCOC1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues regulation[Lnc-OC1/miR-34a/PD-L1 axis ] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay Our results suggested that Lnc-OC1 was significantly upregulated in EC tissues comparing with normal tissues.Concisely, our results proved that Lnc-OC1/miR-34a/PD-L1 axis might serve as a therapeutic target of EC. Yes Moreover, knockdown of Lnc-OC1 leaded to an inhibition of cell viability and a raise of cell apoptosis. 32748220 lnc-IUR LncRNA Homo sapiens pancreatic adenocarcinoma PAAD tissue Interaction(miR-34a/CD44 Signaling Pathway ) qRT-PCR//Western Blot The results demonstrated that IUR was downregulated in PAAD tissue compared with adjacent non-tumor tissue samples and that low expression levels of IUR correlated with poor survival in patients with PAAD. In PAAD tissue samples, the expression of IUR positively correlated with miR-34a expression but negatively correlated with CD44 expression, which is a target of miR-34a. The results demonstrated that IUR was downregulated in PAAD tissue compared with adjacent non-tumor tissue samples and that low expression levels of IUR correlated with poor survival in patients with PAAD. Yes In PAAD cells, overexpression of IUR resulted in miR-34a upregulation and CD44 downregulation. miR-34a overexpression did not affect the expression of IUR but downregulated CD44. In PAAD cells, overexpression of IUR and miR-34a led to decreased invasive and migratory abilities. However, CD44 overexpression played an opposite role and attenuated the effects of IUR and miR-34a overexpression. 34113395 lncINS-IGF2 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Expression[highly expressed] Wound Healing Assay//CCK8//qRT-PCR//Microarray//Cell Cycle Assay//Colony Formation Assay//Transwell Assay Among the dysregulated long noncoding RNAs, we identified INS-IGF2 readthrough, transcript variant 1, noncoding RNA (NR_003512.3) is upregulated in non-small-cell lung cancer tissues, the cis gene of which is insulin-like growth factor 2 gene hinted by bioinformatics analysis. Yes Furthermore, INS-IGF2 readthrough, transcript variant 1, noncoding RNA downregulation suppresses non-small-cell lung cancer cell proliferation and migration. 30803359 LncIHAT LncRNA Homo sapiens Breast Neoplasms interaction[HIF1] qRT-PCR Hypoxia-inducible factor 1 (HIF1) but not HIF2 bound to the hypoxia response element at the promoter of lncIHAT to activate its transcription in hypoxic TNBC cells.This study systematically identified hypoxia-induced lncRNA transcriptome in TNBC and sheds light on multiple layers of regulatory mechanisms of gene expression under hypoxia. Yes LncIHAT promoted TNBC cell survival in vitro and tumor growth and lung metastasis in mice. 33380467 lncHUPC1 LncRNA Homo sapiens Prostatic Neoplasms PCa cells and 70 PCa cases Interaction( miR-133b/SDCCAG3) In Vivo Experiment//Western Blot//qPCR//CCK8//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//ChIP Using q-PCR, lncHUPC1 and SDCCAG3 were found to be up-regulated in PCa cells, while miR-133b was down-regulated. The same results were found in tissue samples from 70 PCa cases.In conclusion, the ceRNA network of lncHUPC1/miR-133b/SDCCAG3 affected the growth and apoptosis of PCa cells, and FOXA1 may be involved in the process as a transcription factor of lncHUPC1. Yes It was confirmed that the knockdown of lncHUPC1 increased the expression of miR-133b and decreased that of SDCCAG3, which further increased apoptosis and inhibited cell growth, while the miR-133b inhibitor partially reversed these effects. After transfection with miR-133b mimic after lncHUPC1-knockdown, the expression of miR-133b increased while that of SDCCAG3 reduced, and the apoptosis of the cells was more obvious and the growth of the cells was slower. 35812058 lnc-HSD17B11-1:1 LncRNA Homo sapiens Colorectal Neoplasms CRC primary tissues regulation[lnc-HSD17B11-1:1/miR-338-3p/MACC1 axis] qRT-PCR//Luciferase Report Assay//RIP//Western Blot Evidently up-regulation of lnc-HSD17B11-1:1 in CRC primary tissues was correlated with the depth of invasion (p = 0.043), clinical stage (p = 0.027), distant metastasis (p = 0.003) and poor prognosis of patients with CRC.These findings suggest that lnc-HSD17B11-1:1 promotes CRC progression through lnc-HSD17B11-1:1/miR-338-3p/MACC1 axis and this might serve as a new diagnostic marker or target for treatment of CRC. Evidently up-regulation of lnc-HSD17B11-1:1 in CRC primary tissues was correlated with the depth of invasion (p = 0.043), clinical stage (p = 0.027), distant metastasis (p = 0.003) and poor prognosis of patients with CRC. Yes lnc-HSD17B11-1:1 promoted CRC cell proliferation, mobility and invasion in vitro and in vivo. 32595704 lnc-HLX-2-7 LncRNA Homo sapiens Medulloblastoma MB cell line Expression(highly expressed) In Vivo Experiment//qRT-PCR//Colony Formation Assay//EdU Staining Lnc-HLX-2-7 is highly upregulated in Group 3 MB cell lines, patient-derived xenografts, and primary MBs compared with other MB subgroups as assessed by quantitative real-time, RNA-seq, and RNA fluorescence in situ hybridization. Depletion of lnc-HLX-2-7 significantly reduced cell proliferation and 3D colony formation and induced apoptosis. Lnc-HLX-2-7-deleted cells injected into mouse cerebellums produced smaller tumors than those derived from parental cells. Pathway analysis revealed that lnc-HLX-2-7 modulated oxidative phosphorylation, mitochondrial dysfunction, and sirtuin signaling pathways. The MYC oncogene regulated lnc-HLX-2-7, and the small-molecule bromodomain and extraterminal domain family‒bromodomain 4 inhibitor Jun Qi 1 (JQ1) reduced lnc-HLX-2-7 expression. Yes Depletion of lnc-HLX-2-7 significantly reduced cell proliferation and 3D colony formation and induced apoptosis. 33844835 LNC-HCG11 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-224-3p/c-caspase-3 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining Lnc-HCG11 was significantly reduced in NSCLC.Lnc-HCG11 could inhibit the progression of NSCLC by modulating the miR-224-3p/caspase-3 axis, and Lnc-HCG11 may be a potential therapeutic target for NSCLC. Yes Lnc-HCG11 significantly inhibited cell proliferation of NSCLC cells and induced apoptosis. 32694917 LNC-HC LncRNA Homo sapiens Carcinoma, Hepatocellular hepatic tumors regulation[Sequestering hsa-miR-183-5p] qRT-PCR//Wound Healing Assay//MTT In this study, we identified a novel human lncRNA, LNC-HC, with significantly reduced levels in hepatic tumors from patients with HCC.Overall, human LNC-HC was identified as a novel tumor suppressor that could inhibit HCC cell proliferation in vitro and suppress tumor growth in vivo by competitively binding hsa-miR-183-5p as a competing endogenous RNA (ceRNA). Yes Xenograft transplantation of LNC-HC-overexpressing Huh7 cells in nude mice resulted in the production of smaller tumors. 32278306 lnc-H2AFV-1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues and cells Regulation(m6A methylases METTL3/14 and FTO) CCK8//qRT-PCR The present study evaluated the expression of lnc-H2AFV-1 in HNSCC tissues using quantitative real-time PCR (qPCR) and associated abundant lnc-H2AFV-1 expression with tumor size. Thus, our findings suggested that lnc-H2AFV-1 might be a biomarker that alters m6A modification by regulating the m6A methylases METTL3/14 and FTO and then mediating the downstream target IFT80 to promote HNSCC progression. Yes Functionally, lnc-H2AFV-1 significantly promoted the proliferation of HNSCC cells in vitro and in vivo. 35403343 lnc-GNAT1-1 LncRNA Homo sapiens Liver Neoplasms liver cancer tissues, cell lines regulation[inhibiting EMT] CCK8//qRT-PCR//Colony Formation Assay//Flow Cytometry Downregulation of lnc-GNAT1-1 was observed in cancerous tissues from patients with liver cancer and in liver cancer cell lines, and low expression levels of lnc-GNAT1-1 were related to advanced TNM stage. Mechanistic experiments revealed that lnc-GNAT1-1 exerted anti-tumor effects in liver cancer cells by inhibiting EMT. Downregulation of lnc-GNAT1-1 was observed in cancerous tissues from patients with liver cancer and in liver cancer cell lines, and low expression levels of lnc-GNAT1-1 were related to advanced TNM stage. Yes Lnc-GNAT1-1 knockdown promoted invasion, migration, and proliferation of liver cancer cells and inhibited apoptosis, while lnc-GNAT1-1 upregulation exerted the opposite effects. 33193591 lnc-GLRX3 LncRNA Homo sapiens Atherosclerosis carotid plaque Regulation RNA Pull-Down//Transfection//RIP//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay Next, lncRNA_FGF7-5 and lncRNA_GLRX3 targeted miR-2681-5p directly to upregulate ERCC4 expression.Taken together, these findings indicated that lncRNA_FGF7-5 and lncRNA_GLRX3 together reduced atherosclerosis-induced apoptosis of HUVECs via targeting miR-2681-5p to increase ERCC4 expression, thereby preventing the formation of carotid plaque and finally inhibiting atherosclerosis progression. Yes Silencing of lncRNA_FGF7-5 and lncRNA_GLRX3 promoted apoptosis and TP53 expression in HUVECs treated with ox-LDL; however, these effects were reversed by ERCC4-overexpression. 36071684 lncGHET1 LncRNA Homo sapiens Osteosarcoma OS cell lines regulation[Wnt/β-catenin signaling pathway] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay lncGHET1 expression was significantly upregulated in OS cell lines compared with in an osteoblastic cell line according to the RT?qPCR assay. The results of a knockdown functional experiment suggested that inhibition of lncGHET1 attenuated cell proliferation, migration, invasion and epithelial‑to‑mesenchymal transition, and promoted apoptosis, partly through regulating the Wnt/β‑catenin signaling pathway in OS. Yes The results of a knockdown functional experiment suggested that inhibition of lncGHET1 attenuated cell proliferation, migration, invasion and epithelial?to?mesenchymal transition, and promoted apoptosis, partly through regulating the Wnt/β?catenin signaling pathway in OS. 32319657 lnc-GAN1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung HCC tissues Interaction(miR-26a-5p/PTEN) Western Blot//Co-IP//Colony Formation Assay//qRT-PCR//Luciferase Report Assay//IHC//ChIP lnc-GAN1 is downregulated in HCC tissues and associated with larger tumor size and poor overall survival and disease-free survival. Mechanistically, lnc-GAN1 acts as a sponge for miR-26a-5p by two seed sequences, and the two non-coding RNAs have a negative relationship in NSCLC tissues; we further prove that PTEN is a direct target of miR-26a-5p and lnc-GAN1 inhibits cell cycle signaling pathway by activating PTEN, whose expression level correlated negatively with miR-26a-5p level but positively with lnc-GAN1 level in NSCLC samples. lnc-GAN1 is downregulated in HCC tissues and associated with larger tumor size and poor overall survival and disease-free survival Yes its ectopic expression suppresses cell proliferation, colony formation, and cell cycle progression and induces apoptosis in NSCLC cells; it also inhibits tumor growth in the NSCLC xenograft model. 33407724 lnc-FoxD2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR‑4306) CCK8//qRT-PCR//Western Blot Compared with normal samples and cells, FoxD2‑AS1 expression was increased and miR‑4306 expression was decreased in CRC tissues and cells. Furthermore, investigations into the underling mechanism revealed that FoxD2‑AS1 functioned as a molecular sponge of miR‑4306. Yes Functional experiments demonstrated that silencing FoxD2‑AS1 inhibited proliferation and induced cell arrest at G0/G1 phase in CRC cells, while the overexpression of FoxD2‑AS1 showed opposite results. Ki‑67 and proliferating cell nuclear antigen expression levels were decreased after transfection with small interfering RNA FoxD2‑AS1, but were increased after transfection with FoxD2‑AS1 overexpression plasmid. 34396433 lncFGD5-AS1 LncRNA Homo sapiens Stomach Neoplasms 30 gastric cancer patients' cancer tissue and para-cancer tissue Interaction(miR-196a-5p/SMAD6/BMP axis ) In Vivo Experiment//Western Blot//Migration Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Bioinformatics Analysis LncFGD5-AS1 served as a ceRNA of miR-196a-5p to release its inhibition on SMAD6, a conventional inhibitor on the BMP pathway. Yes Comparing with normal gastric cancer cells, FGD5-AS1 overexpressed group had fewer migration cells, lower cell viability, and lower EMT transformation rate. Meanwhile, xenografts nude mice injecting with overexpressed-FGD5-AS1 cells also shown smaller tumor weight and volume. 33892661 lncDQ LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction（EZH2） qRT-PCR LncDQ was upregulated in both HCC tissue samples and serum and was correlated with low survival rate and adverse clinical pathological characteristics. Mechanistically, LncDQ regulated the epithelial-mesenchymal transition pathway by interacting with EZH2, to epigenetically repress the expression of E-cadherin in HCC cells. LncDQ was upregulated in both HCC tissue samples and serum and was correlated with low survival rate and adverse clinical pathological characteristics. Multivariate analysis demonstrated that LncDQ expression was an independent prognostic factor for HCC. The area under the receiver operating characteristic curve was 0.804 with a sensitivity of 0.72 and a specificity of 0.8. Yes Knockdown of LncDQ induced inhibition of cell proliferation, migration, and invasion in vitro and in vivo. 29669339 lnc-DILC LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Interaction[WWP2 and USP11] RNA Pull-Down//Western Blot//Co-IP//qRT-PCR//RIP Here, we identified that lnc-DILC levels were dramatically downregulated in ccRCC tissues.In summary, our research revealed a novel mechanism by which lnc-DILC regulates PTEN stability via WWP2 and USP11, and shed light on potential therapeutic strategies by the restoration of lnc-DILC expression in patients with ccRCC. Loss of lnc-DILC expression was correlated with larger tumor size, advanced tumor grade and lymph node metastasis, and also predicted worse prognosis in patients with ccRCC. Yes Functionally, knockdown and overexpression experiments demonstrated that lnc-DILC inhibited cell proliferation, migration and invasion in ccRCC cells. 31592114 lnc-DILC LncRNA Homo sapiens gallbladder carcinoma GBC tissues,cell lines Regulation[Wnt/β-catenin signaling] Western Blot//Flow Cytometry//qRT-PCR//Cell Proliferation Assay//migration assay//Luciferase Report Assay//cell invasion assay Herein, we show that lnc-DILC is upregulated in gallbladder CSCs and GBC patients' tissues. In conclusion, lnc-DILC drives gallbladder CSCs self-renewal, tumorigenicity, proliferation and metastasis by activating Wnt/β-catenin signaling, and may therefore prove to be a potential therapeutic target for GBC patients. Yes Knockdown of lnc-DILC attenuates the self-renewal, tumorigenicity, proliferation and metastasis of gallbladder CSCs. 30716440 LncDBH-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell lines and tissue samples Interaction(miR-155/AXIN1 axis) qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP The DBH-AS1 expression was significantly down-regulated in NSCLC cell lines and tissue samples. The mechanism was that DBH-AS1 regulated AXIN1 expression by sponging miR-155 in NSCLC cell lines. Importantly, LncDBH-AS1 might inhibit WNT/β-CATENIN activation in NSCLC cells. Yes Decreased DBH-AS1 levels promoted the in vitro proliferation of the NSCLC cells. 33506901 lnc-KIAA1244-2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma Expression[highly expressed] qRT-PCR//Microarray Furthermore, we investigated the function and potential mechanism of a novel highly expressed lncRNA, lnc-KIAA1244-2, and found that its expression is associated with tumor size, N classification and clinical stage. Furthermore, we investigated the function and potential mechanism of a novel highly expressed lncRNA, lnc-KIAA1244-2, and found that its expression is associated with tumor size, N classification and clinical stage. Yes Knockdown of lnc-KIAA1244-2 inhibited the cell proliferation and inhibited the TNFAIP3 expression in Eca-109 cells. 31235759 LncKLHDC7B LncRNA Homo sapiens Triple Negative Breast Neoplasms tumor tissues Interaction[RUNX3] qRT-PCR//Microarray We discovered that LncKLHDC7B (ENSG00000226738) acts as a transcriptional modulator of its neighboring coding gene KLHDC7B in the immunomodulatory subtype. Furthermore, LncKLHDC7B knockExpression[down-expression] enhanced migration and invasion, and promoted resistance to cellular death. Our findings confirmed the contribution of LncKLHDC7B to induction of apoptosis and inhibition of cell migration and invasion, suggesting that TNBC tumors with enrichment of LncKLHDC7B may exhibit distinct regulatory activity, or that this may be a generalized process in breast cancer. Additionally, in silico analysis confirmed for the first time that the low expression of KLHDC7B and LncKLHDC7B is associated with poor prognosis in patients with breast cancer. Yes The knockExpression[down-expression] of LncKLHDC7B was achieved with ~ 75% silencing efficiency (Fig. 4B) and a 50% inhibition of the expression of KLHDC7B gene 30648789 lncKRT16P6 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and cell lines Interaction(miR‑3180/GATAD2A ) In Vivo Experiment//qRT-PCT//Western Blot//CCK8//Flow Cytometry//FISH//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Through RNA screening, the present study identified a novel long noncoding RNA (lncRNA), keratin 16 pseudogene 6 (lncKRT16P6), which was upregulated in TSCC tissues and cell lines and associated with TSCC tumor stage and differentiation grade. lncKRT16P6 sponged microRNA (miR)‑3180 and upregulated GATA zinc finger domain containing 2A (GATAD2A) expression. miR‑3180 inhibition reversed the lncKRT16P6 depletion‑induced attenuation of TSCC malignancy and GATAD2A depletion reversed the miR‑3180 silencing‑induced enhancement of TSCC malignancy. Through RNA screening, the present study identified a novel long noncoding RNA (lncRNA), keratin 16 pseudogene 6 (lncKRT16P6), which was upregulated in TSCC tissues and cell lines and associated with TSCC tumor stage and differentiation grade. Yes Inhibition of lncKRT16P6 expression reduced TSCC cell migration, invasion and proliferation. 35904180 LncNAP1L6 LncRNA Homo sapiens Prostatic Neoplasms PCa cells Interaction(HNRNPC/NAP1L2) RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//MeRIP//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Firstly, RT-qPCR analysis was to detect lncNAP1L6 expression and suggested that lncNAP1L6 was markedly upregulated in PCa cells. It turned out that METTL14/METTL3 complex mediated m6A methylation of NAP1L2 mRNA. Besides, lncNAP1L6 recruited HNRNPC to m6A-modified NAP1L2, leading to stabilization of NAP1L2 mRNA. Moreover, NAP1L6 interacted with YY1 to promote the transcription of MMP2 and MMP9 and activate MMP signaling pathway. Yes Functional assays manifested that silencing of lncNAP1L6 hampered cell migration, invasion, and epithelial-mesenchymal transition (EMT) while overexpression of lncNAP1L6 exacerbated cell migration, invasion and EMT. 36195720 LNCOC1 LncRNA Homo sapiens Melanoma 65 melanoma patients Interaction(miR-124) qRT-PCR//Transwell Assay LNCOC1 was accumulated to high levels in melanoma, and it was significantly correlated with the low survival rate of melanoma patients. Our bioinformatics data showed that miR-124 could target LNCOC1. Overexpression of miR-124 could downregulate LNCOC1. However, up-regulated the expression of LNCOC1 did not affect the expression of miR-124. LNCOC1 was accumulated to high levels in melanoma, and it was significantly correlated with the low survival rate of melanoma patients. Yes However, overexpression of LNCOC1 promoted melanoma cell invasion and migration. 35502349 LncNORAD LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[CXCR4 and RhoA/ROCK signaling pathway] CCK8//qRT-PCR//Western Blot NORAD has elevated the levels in NSCLC tissues and cells. This study revealed that the downregulation of lncRNA NORAD could slow down the progression of NSCLC by regulating CXCR4 and RhoA/ROCK signaling pathway. Yes NORAD interference dramatically inhibited tumor growth and suppressed A549 cell proliferation, migration and invasion by downregulating CXCR4 and CXCL12 expression. 32495879 lncNNT-AS1 LncRNA Homo sapiens Glioma cell lines regulation[miR-494-3p/PRMT1 axis] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//BrdU//Transwell Assay In particular, high levels of NNT-AS1 are observed in glioma cell lines compared to human astrocyte (HA) cells.Collectively, our results indicated that the miR-494-3p-PRMT1 axis is involved the tumor-suppressive effects of NNT-AS1 inhibition, which sheds new light on lncRNA-directed diagnostics and the therapeutics of glioma. Yes Furthermore, the inhibition of lnc-NNT-AS1 by siRNA interfere attenuates the cell viability, proliferation, migration and invasion of glioma cell lines. 32420808 lnc-NLC1-C LncRNA Homo sapiens Glioma U87MG glioma cells Interaction(miR-383/PRDX-3 axis ) Western Blot//Transfection//Migration Assay//qRT-PCR//Cell Proliferation Assay//Cell Cycle Assay//Invasion Assay The highest expression levels of lnc-NLC1-C were identified in U87MG glioma cells. Mechanistically, miR-383 could bind to lnc-NLC1-C to regulate PRDX-3 expression and improve its oncogenic effect. Rescue experiments confirmed that the lnc-NLC1-C/miR-383/PRDX-3 axis was involved in the molecular mechanism of glioma progression. Yes Overexpression of lnc-NLC1-C expression promoted cell proliferation, G1 phase blocking, migration and invasion, while inhibiting apoptosis and autophagy in U87MG cells. 34386062 LNCNEF LncRNA Homo sapiens Osteosarcoma blood Interaction[downregulating miRNA-21] qRT-PCR//Transwell Assay The present study revealed that plasma lncRNA-NEF was downregulated, while miRNA-21 was Expression[up-expression]regulated in patients with osteosarcoma compared with healthy controls.lncRNA-NEF overexpression mediated the inhibition of miRNA-21 expression in osteosarcoma cell lines, while miRNA-21 overexpression did not significantly affect the expression of lncRNA-NEF. miRNA-21 overexpression partially compensated the inhibitory effects of lncRNA-NEF overexpression on osteosarcoma cell migration and invasion. Yes lncRNA-NEF overexpression inhibited, while miRNA-21 overexpression promoted, migration and invasion of osteosarcoma cell lines in vitro. 31186758 Lnc-NEAT1 LncRNA Homo sapiens Hepatic Ischemia/Reperfusion Injury Human liver cells (HL-7702) Expression(highly expressed) Western Blot//Transfection//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//ELISA Lnc-NEAT1 expression was elevated in the I/R group compared with the normal group. Yes Cell proliferation was decreased in the NEAT1(+) group compared with the NC(+) group but increased in NEAT1(-) compared with NC(-). The apoptosis rate increased in the NEAT1(+) group compared with the NC(+) group but decreased in NEAT1(-) compared with NC(-). Western blot assay (detection of apoptosis-related proteins) showed similar results. Expression of interleukin-1β, interleukin-6, and tumor necrosis factor-α increased in the NEAT1(+) group compared with NC(+) but decreased in NEAT1(-) compared with NC(-). 33682508 lnc-NEAT1 LncRNA Mus musculus Parkinson Disease PD mouse models and cell models Interaction(MiR-212-3p/AXIN1 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA NEAT1 was upregulated in PD mouse models and cell models. MiR-212-3p was downregulated in PD, and its inhibitor could reverse the suppression effect of NEAT1 knockdown on PD progression. Additionally, AXIN1 was a target of miR-212-3p, and its overexpression could invert the inhibition effect of miR-212-3p mimic on PD progression. Yes Function experiments confirmed that NEAT1 knockdown could promote the viability, suppress the apoptosis and inflammation of MPP+-stimulated SK-N-SH cells to restrain PD progression. 33241432 lnc-n339260 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miRNA30e-5p/TP53INP1) qRT-PCR LncRNA n339260 promotes the development of VM, and lncRNA n339260 may enhance Snail expression by decreasing the expression of miRNA30e-5p, thereby reducing TP53INP1 expression. Therefore, a potential lncRNA n339260- miRNA30e-5p- TP53INP1 regulatory axis was associated with HCC progression. LncRNA n339260 and miRNA30e-5p were found to be associated with VM formation, metastasis and survival time in HCC patients. Yes In vivo experiment showed lncRNA n339260 promoted tumor growth and VM formation. 35802258 lnc-LIFR-AS1 LncRNA Homo sapiens stomach carcinoma GC tissues and cells Interaction(miR‑4698 /MTUS1) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//cell invasion assay//Bioinformatics Analysis Decreased lncRNA LIFR‑AS1 expression was observed in GC tissues and cells. Upregulated miR‑4698 and downregulated MTUS1 were identified in GC tissues and cells. Upregulated miR‑4698 and downregulated MTUS1 were identified in GC tissues and cells. The inhibitory interaction between lncRNA LIFR‑AS1 and miR‑4698 was confirmed. Additionally, MTUS1 was predicted as a target gene of miR‑4698 positively regulated by lncRNA LIFR‑AS1. The MEK/ERK pathway was inhibited by lncRNA LIFR‑AS1 via regulating MTUS1. Yes Upregulated lncRNA LIFR‑AS1 inhibited GC cell proliferation, migration and invasion. 33355363 lnc-MTX2-6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma 80 paired ESCC tissues and matched adjacent tissues Interaction(miR-574-5p/SMAD4 axis) Tunel//CCK8//qRT-PCR//RIP//IHC In this study, we first reported that lncRNA MTX2-6 was significantly downregulated in ESCC tissues and cell lines. Further studies showed that MTX2-6 exerts as a competing endogenous RNA (ceRNA) by binding miR-574-5p and elevates the expression of SMAD4 in ESCC. The decreased expression of MTX2-6 is closely related to larger tumor and worse prognosis of ESCC patients. Yes Through a series of functional experiments, we detected that overexpressed MTX2-6 inhibited cell proliferation and promoted cell apoptosis of ESCC in vitro and in vivo. 33869216 lnc-MPEG1-1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC cell lines Interaction(papillary thyroid cancer) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//H&E Staining//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Microarray//Colony Formation Assay//EdU Staining//Transwell Assay In particular, in vivo and in vitro experiments showed that overexpression of lnc-MPEG1-1:1 in PTC cell lines promoted the proliferation and migration of PTC. lnc-MPEG1-1:1 is overexpressed in the cytoplasm of PTC cells and functionally promotes cellular proliferation and migration and functions as a competitive endogenous RNA (ceRNA) by competitively occupying the shared binding sequences of miR-766-5p. lnc-MPEG1-1:1 knockdown suppressed epithelial-mesenchymal transition by miR-766-5p in PTC cells. Yes lnc-MPEG1-1:1 knockdown suppressed epithelial-mesenchymal transition by miR-766-5p in PTC cells. 35505969 lncMMPA LncRNA Homo sapiens Carcinoma, Hepatocellular tumor cells Interaction(miR-548) qRT-PCR Mechanistically, lncMMPA not only could polarize M2 macrophage, but also could act as an microRNA sponge to interact with miR-548 s and increase the mRNA level of ALDH1A3, then further promote glucose metabolism and cell proliferation in HCC. Moreover, lncMMPA increased HCC cell multiplication through interacting with miR-548 s in vivo. Clinically, lncMMPA expression associates with glycolysis in TAMs and reduced survival of HCC patients. Yes Mechanistically, lncMMPA not only could polarize M2 macrophage, but also could act as an microRNA sponge to interact with miR-548 s and increase the mRNA level of ALDH1A3, then further promote glucose metabolism and cell proliferation in HCC. Moreover, lncMMPA increased HCC cell multiplication through interacting with miR-548 s in vivo. Clinically, lncMMPA expression associates with glycolysis in TAMs and reduced survival of HCC patients. 35986343 lnc-MEG3 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Regulation(SQSTM1) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Transwell Assay Downregulated lnc-MEG3 expression and upregulated SQSTM1 expression were found in NPC tissues and cells.Overexpression of lnc-MEG3 reduced the expression level of SQSTM1, and SQSTM1 expression was inversely correlated with lnc-MEG3 level in NPC tissues. Besides, overexpression of SQSTM1 reversed the effects of lnc-MEG3 overexpression. Yes Overexpression of lnc-MEG3 inhibited invasion, migration, and epithelial-mesenchymal transition in NPC cells. 34704649 Lnc-MAP6-1:3 LncRNA Homo sapiens Osteosarcoma cell lines regulation[Bax/Bcl-2 and Wnt/β-catenin pathways] qRT-PCR//Western Blot As a result, we were able to find a novel lncRNA Lnc-MAP6-1:3 which is highly expressed in osteosarcoma. For the first time, we have identified that Lnc-MAP6-1:3 potentially influence the malignant behavior of osteosarcoma via Bax/Bcl-2 and Wnt/β-catenin signaling pathways. Yes Using a set of approaches including gene knockdown, RT-PCR, oncogenic function assay and western blotting, we observed that knockdown of Lnc-MAP6-1:3 expression suppressed cell proliferation and colony formation, and promoted apoptosis in vitro. 32922188 lnc-MAP3K13-7:1 LncRNA Homo sapiens Polycystic Ovary Syndrome granulosa cell regulation[CDKN1A/p21 expression] Western Blot//Co-IP//CCK8//qRT-PCR//RIP//Cell Apoptosis Assay//Cell Cycle Assay//IF We observed that lnc-MAP3K13-7:1 was highly expressed in GCs from patients with PCOS.Our work uncovered a novel and essential mechanism through which lnc-MAP3K13-7:1-dependent DNMT1 inhibition regulates CDKN1A/p21 expression and inhibits GC proliferation. Yes In KGN cells, lnc-MAP3K13-7:1 overexpression resulted in cell cycle arrest in the G0/G1 phase, as well as the molecular inhibition and genetic silencing of DNMT1. 33212300 lnc-LOC LncRNA Homo sapiens Carcinoma, Hepatocellular HCC patients Expression [highly expressed] qRT-PCR LOC101926913 (LOC) was further characterized because it is the most highly differentially expressed amongst those that are associated with the most number of clinical features (tumor-stage, vascular and tumor invasion and poorer overall survival). Experimental gain- and loss-of-function manipulation of LOC in liver cell-lines highlight LOC as a potential onco-lncRNA promoting cell proliferation, anchorage independent growth and invasion. Yes Experimental gain- and loss-of-function manipulation of LOC in liver cell-lines highlight LOC as a potential onco-lncRNA promoting cell proliferation, anchorage independent growth and invasion. 33976720 LPAL2 LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma (HCC) tissues Interaction(MMP9 ) qRT-PCR In the current study, we found that the pseudogene-derived lncRNA LPAL2 is downregulated in hepatocellular carcinoma (HCC) tissues, and further showed that elevated LPAL2 expression is positively correlated with survival outcome. Metalloproteinase 9 (MMP9) was identified as an LPAL2-regulated target gene, consistent with clinical findings that LPAL2 expression is significantly associated with MMP9 expression. Furthermore, patients with a higher expression of LPAL2 and lower expression of MMP9 (LPAL2-high/MMP9-low) had a higher survival rate than those with other combinations. In the current study, we found that the pseudogene-derived lncRNA LPAL2 is downregulated in hepatocellular carcinoma (HCC) tissues, and further showed that elevated LPAL2 expression is positively correlated with survival outcome. Yes The knockdown of LPAL2 in hepatoma cells induced tumor formation, migration, invasion, sphere formation, and drug resistance. 36010685 circCDK17 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(circCDK17/miR-122-5p/ASF1B axis ) In Vivo Experiment//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay CircCDK17 and anti-silencing function 1B histone chaperone (ASF1B) were highly expressed in CC tissues and cells. MiR-122-5p was a target of circCDK17. Silencing circCDK17 inhibited the malignant behaviors of CC cells by releasing miR-122-5p. Moreover, ASF1B was a target of miR-122-5p. Overexpression of ASF1B partially restored the inhibitory effects of circCDK17 silencing on cell proliferation, migration and invasion. Yes Silencing circCDK17 reduced the proliferation, migration and invasion of CC cells. Animal experiments confirmed the anti-tumor effect of circCDK17 knockdown in vivo. 36178207 circACAP2 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cells, clinical cervical cancer samples Interaction(miR-193a-5p/GPX4) RNA Pull-Down//Western Blot//Transfection//CCK8//Luciferase Report Assay The circACAP2 served as a ceRNA of miR-193a-5p and directly interacted with miR-193a-5p in cervical cancer cells. miR-193a-5p was able to target GPX4 and circACAP2 promoted GPX4 expression by sponging miR-193a-5p in cervical cancer cells. Clinically, the expression of circACAP2 and GPX4 was upregulated, and miR-193a-5p expression was downregulated in clinical cervical cancer samples. The expression of miR-193a-5p was negatively correlated with circACAP2 and GPX4, while the circACAP2 expression was positively correlated with GPX4 in the samples. Yes The cervical cancer cell viability was inhibited by circACAP2 knockdown as well. The levels of lipid ROS, iron, and Fe2+ were reduced by circACAP2 depletion in cervical cancer cells. The knockdown of circACAP2 inhibited the cervical cancer cell viability, but the miR-193a-5p inhibitor or GPX4 overexpression could reverse the effect in the cells. The inhibition of miR-193a-5p or GPX4 overexpression repressed the circACAP2 depletion-induced levels of lipid ROS, iron, and Fe2+ in cervical cancer cells. 35847361 MALAT1 LncRNA Homo sapiens Prostatic Neoplasms cell lines Interaction[sponging miR‑1‑3p] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay In the present study, it was demonstrated that MALAT1 was increased while microRNA (miR/miRNA)‑1‑3p was decreased in prostate cancer cell lines.Dual‑luciferase reporter assay results demonstrated that miR‑1‑3p bound to MALAT1 and coronin 1C (CORO1C) 3' untranslated region, and MALAT1 competed with CORO1C for the binding sites of miR‑1‑3p. MALAT1 inhibited the expression of miR‑1‑3p and vice versa. MALAT1 knockdown induced the decline of CORO1C, which was subsequently recovered by the miR‑1‑3p inhibitor. In addition, by inhibiting miR‑1‑3p or overexpressing CORO1C, the silencing of MALAT1‑induced phenotypic alterations were restored. In conclusion, MALAT1 serving as a degradable miRNA sponge, may sequester miR‑1‑3p from CORO1C and by silencing MALAT1, migration, invasion and epithelial‑mesenchymal transition may be inhibited in prostate cancer cells. MALAT1 and CORO1C may serve as novel clinical therapeutic targets for prostate cancer. Yes The silencing of MALAT1 inhibited migration, invasion and epithelial‑mesenchymal transition, when epithelial (E)‑cadherin expression level was increased, and neural (N)‑cadherin, vimentin, Slug and Snail expression levels were decreased. 31485645 MALAT1 LncRNA Homo sapiens Prostatic Neoplasms LNCaP cell lines and CWR22Rv1 cell lines Interaction(miR-145) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//IHC//Invasion Assay The expression of MALAT1 was upregulated in both LNCaP cell lines and CWR22Rv1 cell lines (F=2.882, t=13.370, P<0.001; F=2.268, t=15.859, P<0.001). Using direct binding, MALAT1 suppressed the antitumor function of miR-145, which in turn upregulated transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) via SMAD3 and TGFBR2 (F=2.097, t=5.389, P=0.006; F=1.306, t=4.155, P=0.014). Yes Knockdown of MALAT1 reduced the migratory and invasive capabilities of PCa cells (F=0.017, t=12.212, P<0.001; F=10.723, t=6.016, P=0.002). 34295718 circCCDC66 CircRNA Homo sapiens Glioma 12 pairs of glioma samples Interaction(miR-320a /FOXM1 signaling pathway) CCK8//Transfection//Luciferase Report Assay//Transwell Assay The results showed circCCDC66 was overexpressed in glioma and acted as an oncogene. In mechanism study, circCCDC66 could sponge miR-320a, thereby increasing the expression of FOXM1. Yes CircCCDC66 knockdown suppressed the proliferation, migration, and invasion of glioma cells.  34252882 MALAT1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction( MYBL2/mTOR Axis) qRT-PCR//RNA-seq//Colony Formation Assay In the present study, our findings revealed that MALAT1 plays a critical part in regulating PCa proliferation and glucose metabolism. Silencing MALAT1/MYBL2/mTOR axis in PCa cell lines affects their glycolysis and lactate levels, and we verified these findings in mice. Furthermore, we explored the underlying tumorigenesis functions of MYBL2 in PCa and found that high expression of MYBL2 was positively associated with TNM stage, Gleason score, PSA level, and poor survival rate in PCa patients. Yes Knockdown of MALAT1 affects the protein and mRNA levels of MYBL2. In addition, MALAT1 enhances the phosphorylation level of mTOR pathway by upregulating MYBL2. Knockdown of MALAT1 or MYBL2 in PCa cell lines significantly inhibits their proliferation capacity. 35557985 MALAT1 LncRNA Homo sapiens Prostatic Neoplasms PC cells Expression(highly expressed) CCK8//qRT-PCR//Colony Formation Assay//Flow Cytometry MALAT1 is highly expressed in PC cells.Overall, data suggest that MALAT1 overexpression in PC helps metastasis and tumorigenesis. Also, MALAT1 knockout can be considered a therapeutic and diagnostic target in PC. Yes MALAT1 Knockout in DU-145 cells increases apoptosis and prevents proliferation and migration, and DU-145 transfected cells were unable to migrate based on the scratch recovery test. 36163080 hsa_circ_0037655 CircRNA Homo sapiens Glioma glioma samples and cells Interaction(miR-1229-3p/ITGB8 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Upregulation of circ_0037655 was affirmed in glioma samples and cells. miR-1229-3p acted as a target of circ_0037655, and its upregulation was responsible for the function of si-circ_0037655 in glioma cells. miR-1229-3p functioned as a tumor inhibitor in glioma progression by targeting ITGB8. Yes Tumor formation and metastasis of glioma were inhibited after circ_0037655 was downregulated.  34017919 circGLIS3 CircRNA Homo sapiens Glioma 28 glioma samples and 5 non-tumor brain tissues Expression [highly expressed] In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//FISH//RIP//RNA-seq//Microarray//IHC//Invasion Assay//IF We found that upregulation of circGLIS3 promoted glioma cell migration and invasion and showed aggressive characteristics in tumor-bearing mice. Mechanistically, we found that circGLIS3 could promote the Ezrin T567 phosphorylation level. Yes CircGLIS3 Enhances Migration and Invasion of Glioma Cells in vitro and in vivo 34540823 circASPH CircRNA Homo sapiens Glioma GM specimens and cells Interaction(miR-599/AR/SOCS2-AS1) RNA Pull-Down//Transfection//Immunoblotting//Wound Healing Assay//CCK8//qRT-PCR//circRNA-seq//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay circ-ASPH levels were upregulated in GM specimens and cells. Mechanistically, circ-ASPH counteracted microRNA (miR)-599-mediated androgen receptor (AR) suppression by acting as a sponge for miR-599. The prognostic role of circ-ASPH was identified in patients with GM. Yes Loss/gain of function assays demonstrated that circ-ASPH increased cell proliferation, migration and invasion in GM cells. 33777211 circPTN CircRNA Homo sapiens Glioma glioma cells regulation[circ_PTN/miR-122/SOX6 axis] qRT-PCR//Luciferase Report Assay//Western Blot Circ_PTN was overexpressed in glioma cells, and its knockdown induced cell proliferation inhibition, cell cycle arrest and apoptosis in glioma cells. In addition, mitogen activated kinase-like protein (MAPK)/ERK pathway was involved in circ_PTN/miR-122/SOX6 axis. Yes Circ_PTN was overexpressed in glioma cells, and its knockdown induced cell proliferation inhibition, cell cycle arrest and apoptosis in glioma cells. 31609809 hsa_circ_101064 CircRNA Homo sapiens Glioma glioma tissues and glioma cells regulation[miR-154-5p/ PIWIL1 axis] CCK8//qRT-PCR//Western Blot//Transwell Assay The expression level of Circ_101064 was significantly upregulated in glioma tissues compared with control, and was closely associated with tumor grading and diameter. Furthermore, increased Circ_101064 expression was detected in human glioma cell lines. More importantly, Circ_101064/miR-154-5p/PIWIL1 axis could be a promising therapeutic target for the treatment of this disease. Yes In addition, knockdown of Circ_101064 remarkably suppressed cell proliferation, invasion and migration in glioma cells in vitro. 31941603 MALAT1 LncRNA Homo sapiens Thyroid Neoplasms ATC tissues and cell lines Interaction[miR-200a-3p/FOXA1] RNA Pull-Down//Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay Results showed that MALAT1 expression was enhanced and miR-200a-3p was reduced in ATC tissues and cells. Yes Knockdown of MALAT1 or overexpression of miR-200a-3p inhibited cell proliferation, migration and invasion but increased apoptosis and autophagy formation in ATC cells. 31500506 hsa_circ_0005075 CircRNA Homo sapiens Glioma glioma tissues and cell lines regulation[SIRT1] qRT-PCR Circ_0005075 was significantly up-regulated in glioma tissues and cell lines. Furthermore, it aggravates the malignant progression of glioma by down-regulating SIRT1. Meanwhile, its expression level was significantly higher in glioma patients with lymphatic metastasis or distant metastasis when compared with those with negative metastasis. Yes Knockdown of circ_0005075 decreased the viability, migration, and wound closure percentage of T98-G cells. However, overexpression of circ_0005075 in U87 cells yielded the opposite trends. 31957839 MALAT1 LncRNA Homo sapiens Retinoblastoma RB tissues and cell lines regulation[miR-20b-5p,STAT3] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining Both RB tissues and cells showed highly expressed MALAT1. MALAT1 could increase proliferation and reduce apoptosis by sponging miR-20b-5p to upregulate STAT3 in RB cells. Yes When MALAT1 was downregulated, RB cell proliferation was hindered and apoptosis was accelerated. 32336590 MALAT1 LncRNA Homo sapiens Retinoblastoma RB tissues and cells Interaction(miR-655-3p/ATAD2) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay MALAT1 was upregulated in RB tissues and cells, and it served as a competing endogenous RNA (ceRNA) and inhibited miRNA-655-3p (miR-655-3p) expression, which eventually regulated the expression of miR-655-3p downstream target ATPase Family AAA Domain Containing 2 (ATAD2). The level of ATAD2 significantly increased, while that of miR-655-3p remarkably decreased in RB tissues and cells. Yes MALAT1 depletion inhibited cell proliferation, metastasis, and epithelial-mesenchymal transition (EMT), but promoted apoptosis in vitro and blocked xenograft tumor growth in vivo. MALAT1 exerted its oncogenic functions in RB by regulating miR-655-3p/ATAD2 axis. 34222668 MALAT1 LncRNA Homo sapiens Retinoblastoma retinoblastoma cell Interaction(miR-124/STX17) qRT-PCR//Luciferase Report Assay//Western Blot In the present study, we investigated the roles of MALAT1 and miR-124 in the regulation of retinoblastoma cell autophagy through evaluating the changes of autophagy-related proteins. Further, we investigated whether Syntaxin 17 (STX17), a Soluble NSF Attachment Protein receptor (SNARE) of the autophagosome, is involved in MALAT1/miR-124 regulation of retinoblastoma cell autophagy, and the underlying mechanism. Yes Through direct targeting miR-124, MALAT1 promotes retinoblastoma cell autophagy. 29073720 hsa_circ_0037655 CircRNA Homo sapiens Glioma glioma tissues and cell lines (U251 and SHG-44) regulation[ miR-214/PI3K signaling] CCK8//qRT-PCR//Luciferase Report Assay//Microarray//Transwell Assay The circRNA circ_0037655 was highly expressed in both glioma tissues and cell lines (U251 and SHG-44) compared to control. This study identified circRNAs expression profile in gliomas and revealed that circ_0037655 could promote glioma progression by regulating miR-214/PI3K signaling, which may provide new therapeutic approach for gliomas. Yes Inhibition of circ_0037655 could suppress the viability and invasion of glioma cells. 32001271 MALAT1 LncRNA Homo sapiens Melanoma melanoma tissue regulation[Downregulating miR-23a] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Compared with corresponding non-tumor normal tissues, lncRNA MALAT1 in melanoma tissue increased while miR-23a decreased. lncRNA MALAT1 promotes malignant proliferation of melanoma cells through miR-23a. Yes Downregulating lncRNA MALAT1 or upregulating miR-23a inhibited cell proliferation, migration and invasion and promoted apoptosis. 32801893 hsa_circ_0088732 CircRNA Homo sapiens Glioma glioma tissues regulation[miR-661/RAB3D Axis] Western Blot//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay We verified that hsa_circ_0088732 is circular and highly expressed in glioma tissues.We demonstrated that hsa_circ_0088732 facilitated glioma progression by sponging miR-661 to increase RAB3D expression. Yes Knockdown of hsa_circ_0088732 induced glioma cell apoptosis and inhibited glioma cell migration, invasion, and epithelial-mesenchymal transition (EMT). 32154171 circKIF4A CircRNA Homo sapiens Glioma glioma cells and tissues regulation[miR-139-3p/Wnt5a axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay circKIF4A and Wnt5a were up-regulated and miR-139-3p was down-regulated in both glioma cells and tissues. circKIF4A was overexpressed in glioma, and knockdown of circKIF4A suppressed glioma progression via miR-139-3p/Wnt5a axis. Yes Knockdown of circKIF4A inhibited the colony formation ability, migration and invasion, and promoted the apoptosis of glioma cells by regulating miR-139-3p. 32268875 MALAT1 LncRNA Homo sapiens tongue squamous cell carcinoma tongue cancer tissues,blood Interaction[downregulating MMP-9] Western Blot//CCK8//qRT-PCR//Invasion Assay//Transwell Assay The expression level of MALAT1 was remarkably higher in tumor tissues than that in adjacent healthy tissues. Serum MALAT1 was significantly higher in tongue cancer patients than in healthy controls.MALAT1 knockdown also reduced the phosphorylation level of Akt as well as the expression level of MMP-9. It showed no significant effects on Akt expression, while PI3K activator treatment reduced the inhibitory effects of MALAT1 knockdown on the proliferation, migration and invasion of tongue cancer cells. Yes MALAT1 knockdown markedly inhibits the proliferation, migration and invasion of tongue cancer cells. 30657561 MALAT1 LncRNA Homo sapiens Prostatic Neoplasms PCa tumor tissues and cell lines regulation[miR-140/BIRC6 axis] RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//EdU Staining//Transwell Assay MALAT1 and BIRC6 were highly expressed in human PCa tumor tissues and cell lines. MALAT1 knockdown hindered PCa progression by regulating miR-140/BIRC6 axis in vitro and in vivo, hinting the potential value of MALAT1 in the management of PCa. Yes MALAT1 or BIRC6 knockdown inhibited cell proliferation, migration and invasion and induced cell apoptosis in PCa. 31935634 MALAT1 LncRNA Homo sapiens Prostatic Neoplasms cell lines Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay n this study, we demonstrated that lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was increased in prostate cancer cells after androgen stimulation, as well as AR. MALAT1 bound to miR-320b and negatively regulated its expression, and vice versa. AR is a target of miR-320b. The phenotypic changes induced by silencing of MALAT1 were abolished by miR-320b inhibition or AR overexpression. Yes The silencing of MALAT1 inhibited dihydrotestosterone (DHT) administration-induced acceleration of proliferation and cell cycle progression, and increase of AR expression in prostate cancer cells. Additionally, MALAT1 knockdown also suppressed the tumorigenesis of prostate cancer cells in nude mice. 30642743 MALAT1 LncRNA Homo sapiens tongue squamous cell carcinoma OSCC tissue Expression[highly expressed] CCK8//qRT-PCR MALAT-1 levels were significantly higher in the OSCC tissue than in the normal tissues (p < 0.004); no significant differences in UCA1, BC200 or SRA RNA levels were observed. Yes Knockdown of MALAT-1 by siRNA significantly suppressed proliferation of SSC4 cells (p < 0.004) and enhanced their apoptosis (p < 0.001). 31360193 MALAT1 LncRNA Homo sapiens Intervertebral Disc Degeneration IDD tissues regulation[MALAT1-miR-503-MAPK pathway] qRT-PCR We validated the decreased expression of MALAT1 in the IDD tissues, which was associated with decreased Collagen II and Aggrecan expression.Our data suggested that the MALAT1-miR-503-MAPK pathway plays a critical role in NPCs, which may be a potential strategy for alleviating IDD. Yes In vitro, overexpressed MALAT1 could attenuate the effect of IL-1β on NPC proliferation, apoptosis, and Aggrecan degradation. In vivo, MALAT1 overexpression attenuated the severity of disc degeneration in IDD model rats. 32228440 MALAT1 LncRNA Homo sapiens Thyroid Neoplasms regulation[miR-204/IGF2BP2/m6A-MYC Signaling] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Transwell Assay Our data indicated that MALAT1 and IGF2BP2 were highly expressed, while miR-204 was poorly expressed in TC.Altogether, the central findings of our study suggest that MALAT1 contributes to TC progression through the upregulation of IGF2BP2 by binding to miR-204. Yes MALAT1 was found to upregulate IGF2BP2 and enhance MYC expression via m6A modification recognition by competitively binding to miR-204, conferring a stimulatory effect on proliferation, migration, and invasion of TC cells, which was accompanied by weakened tumor growth and cell apoptosis. 33312756 circITCH CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-106a-5p/SASH1 Axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, we performed quantitative real-time polymerase chain reaction analysis and identified that circ-ITCH was significantly downregulated in glioma tissues and cell lines. Moreover, miR-106a-5p was found serving as a target of circ-ITCH and miR-106a-5p mimics could reverse the inhibitory effect of circ-ITCH on glioma cell proliferation and invasion. Moreover, miR-106a-5p was found serving as a target of circ-ITCH and miR-106a-5p mimics could reverse the inhibitory effect of circ-ITCH on glioma cell proliferation and invasion. Yes he function assays showed that upregulation of circ-ITCH inhibited glioma cell proliferation and invasion in vitro as well as reduced cell growth in vivo. 33571015 MALAT1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells regulation[miR-146b-5p] qRT-PCR//Luciferase Report Assay The expression of MALAT1 was upregulated in PTC tissues and cells, while a MALAT1 knockdown counteracted cellular activity, migration, and invasion of B-CPAP and K1 cells. The microRNA miR-146b-5p can promote a MALAT1 expression by negatively regulating DNMT3A in PTC. Yes The expression of MALAT1 was upregulated in PTC tissues and cells, while a MALAT1 knockdown counteracted cellular activity, migration, and invasion of B-CPAP and K1 cells. 32343601 MALAT1 LncRNA Homo sapiens Multiple Myeloma cell lines Regulation[Hippo-YAP signaling pathway] CCK8//qRT-PCR//ELISA//Flow Cytometry LncRNA MALAT1 was increased in MM cells and LncRNA MALAT1 interference could inhibit cell proliferation and promote cell apoptosis with the changes in the related proteins. In conclusion, this study showed that LncRNA MALAT1 interference inhibited the proliferation and adhesion of myeloma cells by the up-regulation of miR-181a-5p through activating the Hippo-YAP signaling pathway. Yes LncRNA MALAT1 interference could inhibit cell proliferation and promote cell apoptosis with the changes in the related proteins. 31397203 MALAT1 LncRNA Homo sapiens Multiple Myeloma MM serums and cells regulation[miR-1271-5p/SOX13 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The up-regulation of MALAT1 and the down-regulation of miR-1271-5p were found in MM serums and cells. LncRNA MALAT1 expedited MM tumorigenesis, invasion, and glycolysis via miR-1271-5p/SOX13 axis. Yes MALAT1 knockdown suppressed cell viability, invasion, and glycolysis while expedited cell apoptosis in MM cells. 31953613 MALAT1 LncRNA Homo sapiens Multiple Myeloma four main MM cell lines Interaction(miR-188-5p) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Transfection//Tunel//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay//IHC//EdU Staining Moreover, MALAT1 was shown to be inversely correlated with miR-188-5p expression through direct binding to miR-188-5p, and in turn, miR-188-5p could mediate the MM cell proliferation and apoptosis regulated by MALAT1. Yes Moreover, MALAT1 was shown to be inversely correlated with miR-188-5p expression through direct binding to miR-188-5p, and in turn, miR-188-5p could mediate the MM cell proliferation and apoptosis regulated by MALAT1. 33944676 MALAT1 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer cells Regulation qRT-PCR//Transfection//Bioinformatics Analysis//Western Blot Notably, METTL3 positively regulates the expression of lncRNA MALAT1 in pancreatic cancer cells. Strikingly, lncRNA MALAT1 increased the expression of PD-L1 in pancreatic cancer cells. This finding indicated that METTL3 regulated the expression of PD-L1 possibly via targeting lncRNA MALAT1 in pancreatic cancer cells. Lastly, MALAT1 governed the viability of pancreatic cancer cells. Taken together, lncRNA MALAT1 is involved in METTL3-mediated promotion of PD-L1 expression in pancreatic cancer. Yes This finding indicated that METTL3 regulated the expression of PD-L1 possibly via targeting lncRNA MALAT1 in pancreatic cancer cells. Lastly, MALAT1 governed the viability of pancreatic cancer cells. 36212476 MALAT1 LncRNA Homo sapiens Adenocarcinoma of Lung LAC tissues Interaction[miR-429] qRT-PCR//MTT//Transwell Assay//Western Blot In this paper, we found that LncRNA MALAT1 had high expression in human LAC tissues (vs. paracancerous normal tissue) and human lung adenocarcinoma cells (vs. human normal lung tissue cells).In vitro, LncRNA MALAT1 could block human LAC cells in the G1 phase to inhibit proliferation by reducing the expression of cyclin D1 protein. LncRNA MALAT1 could inhibit the invasion and migration of human LAC cells by decreasing the expression of MMP-9 and vimentin and increasing the expression of E-cadherin. The expression of lncRNA MALAT1 was significantly associated with human lung adenocarcinoma tumor size, lymph node metastasis, and TNM staging, and was negatively correlated with miR-429 expression in lung adenocarcinoma tissues. Yes "To evaluate the effect of LncRNA MALAT1 on LAC cell proliferation, we inhibited MALAT1 in human lung adenocarcinoma cells PG49 and A549 by si-MALAT1-1 or si-MALAT1-2, and RT-qPCR was used to confirm this, as shown in Figure 3A. The cell growth of PG49 and A549 were monitored by MTT assays after LncRNA MALAT1 knockdown in PG49 and A549, and we found that (Figure 3B, ​,3C)3C) the proliferation of PG49 and A549 after LncRNA MALAT1 knockdown were significantly suppressed (P<0.05). " 31933847 circSEPT9 CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-432-5p/LASP1) In Vivo Experiment//RNA Pull-Down//Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay CircSEPT9 was highly expressed in glioma tissues and cell lines. MicroRNA-432-5p (miR-432-5p) was a target of circSEPT9, and circSEPT9 silencing-mediated effects in glioma cells were largely alleviated by the addition of anti-miR-432-5p. MiR-432-5p bound to the 3' untranslated region (3'UTR) of LIM and SH3 protein 1 (LASP1), and LASP1 overexpression largely overturned miR-432-5p-induced effects in glioma cells. Yes CircSEPT9 interference inhibited the proliferation, migration, invasion and glycolytic metabolism and triggered the apoptosis of glioma cells. CircSEPT9 silencing suppressed xenograft tumor growth in vivo. 33915163 circitga7 CircRNA Homo sapiens Glioma glioma tissues and glioma cells Interaction(miR-34a-5p/VEGFA axis) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In our research, we found that the expression of circITGA7 in glioma tissues and glioma cells increased significantly. Through analysis and dual-luciferase report assay, we found that circITGA7 acts as a sponge for miR-34a-5p targeting VEGFA in glioma. Yes Knocking down circITGA7 can significantly inhibit the proliferation of glioma cells and reduce cell metastasis. 33962397 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines interaction[miR-206,Akt/mTOR signaling] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay MALAT1 was significantly up-regulated in both NSCLC tissues and cell lines.lncRNA MALAT1 promotes migration and invasion of NSCLC by targeting miR-206 and activating Akt/mTOR signaling. High expression of MALAT1 correlated positively with tumor size and lymphatic metastasis in NSCLC, whereas no correlation was found between MALAT1 expression and sex, age, clinical stage, and histological grade. Yes We also showed that MALAT1 promoted epithelial-mesenchymal transition, cell migration, and invasion by activating Akt/mTOR signaling in A549 and H1299 cells. 29916897 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[miR-124] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Transwell Assay LncRNA MALAT-1 expression was higher in NSCLC tissues than that in adjacent tissues, but a lower expression of miR-124 was detected in the former tissues than in the latter tissues.By competitively regulating miR-124, MALAT-1 can promote epithelial-mesenchymal transition, thus accelerating the development of NSCLC. Yes Compared with 16HBE cells, MALAT-1 was highly expressed in NSCLC tissues. Compared with the blank group, E-cadherin and cell apoptosis were increased, but vimentin, cell variability, cell invasion, and migration ability in the si-MALAT-1 and miR-124 mimics groups were reduced. 29782349 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction[Down-Regulating miR-202 Expression] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay MALAT1 was overexpressed in NSCLC samples and cell lines.Next, we verified that MALAT1 could act as a competing endogenous RNA (ceRNA) by sponging miR-202 in NSCLC and there is a negative correlation between MALAT1 and miR-202. Besides, overexpression of miR-202 inhibited cell proliferation and invasive ability in MALAT1-overexpressed cells. High expression of MALAT1 was related to large tumor size (>3 cm), poor histological grade, advanced cancer and tumor metastasis in NSCLC. Yes In vitro assays exhibited that knockdown of MALAT1 remarkably decreased A549 cell growth and invasion capacity, while overexpression of MALAT1 significantly enhanced NCI-H292 cell proliferation and invasion ability. 31863664 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-515-3p/ TRIM65 Axis] RNA Pull-Down//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay MALAT1 and TRIM65 expression was upregulated, and miR-515-5p expression was downregulated in NSCLC tissues and cells. Our findings demonstrated that MALAT1 depletion inhibited the growth of NSCLC cells by regulating miR-515-5p/TRIM65 axis, providing the theoretical basis for the therapy of NSCLC. Yes Both MALAT1 knockdown and TRIM65 depletion suppressed cell proliferation, migration, and invasion and induced apoptosis in NSCLC cells. 33395541 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[MALAT1/miR-374b-5p/SRSF7 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay We first observed that the levels of MALAT1 and SRSF7 were upregulated while miR-374b-5p was downregulated in NSCLC tissues; meanwhile, the expression level of MALAT1 was negatively correlated with miR-374b-5p and positively correlated with SRSF7. Our results demonstrated that MALAT1 contributed to NSCLC progression through the MALAT1/miR-374b-5p/SRSF7 axis. Yes Both knockdown of MALAT1 and miR-374b-5p overexpression inhibited proliferation, migration and invasion and induced apoptosis in NSCLC cells. 32141554 hsa_circ_0030018 CircRNA Homo sapiens Glioma Thirty five cases of glioma tissues Interaction(miR-34b-6p targets HuR) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Cell Apoptosis Assay//Colony Formation Assay//Invasion Assay circ_0030018 was overexpressed in glioma tissues and cells, and its silencing could inhibit glioma cell proliferation, migration, invasion, and accelerate apoptosis. Our data showed that circ_0030018 enhanced glioma progression by sponging miR-194-5p to regulate TRIM44, indicating that circ_0030018 might be a potential treatment target for glioma. Yes circ_0030018 was overexpressed in glioma tissues and cells, and its silencing could inhibit glioma cell proliferation, migration, invasion, and accelerate apoptosis. Animal experiments suggested that circ_0030018 knockdown could reduce glioma tumor growth through regulating miR-194-5p and TRIM44. 34150336 circMMP1 CircRNA Homo sapiens Glioma Clinical Samples Interaction( miR-195-5p/TGIF2 axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay CircMMP1 and TGIF2 expression were upregulated, and miR-195-5p expression was downregulated in glioma tissues and cells. The mechanical analysis discovered that circMMP1 acted as a sponge of miR-195-5p to regulate TGIF2 expression. Yes And the knockdown of circMMP1 could block colony formation, migration, and invasion and expedite apoptosis and autophagy in glioma cells. 34471941 MALAT1 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and cells Regulation[miR-140-5p-PAK1 pathway] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The expression of MALAT1 and p21 (RAC1)-activated kinase 1 (PAK1) was upregulated and microRNA-140-5p (miR-140-5p) expression was downregulated in TSCC tissues and cells. MALAT1 contributed to TSCC progression via miR-140-5p-PAK1 regulatory axis, highlighting a potential target for TSCC management. Yes Moreover, MALAT1 knockdown inhibited proliferation, migration, and invasion by upregulating miR-140-5p expression in TSCC cells. 30863103 circCSPP1 CircRNA Homo sapiens Glioma GC tissues and cells Expression[highly expressed] CCK8//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay Circ-CSPP1 expression was significantly up-regulated both in GC tissues and cells. Yes GC cells with low expression of circ-CSPP1 showed significantly reduced proliferation, invasion, and migration abilities. 32495924 LPP-AS2 LncRNA Homo sapiens Glioma glioma tissues regulation[miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP The results of high-throughput RNA-seq indicated lncRNA LPP-AS2 was upregulated in glioma tissues and further confirmed by RT-qPCR. Thus, lncRNA LPP-AS2 promoted glioma tumorigenesis via a miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop. Higher LPP-AS2 expression was related to a poor prognosis in glioma patients. Yes Based on functional studies, LPP-AS2 depletion inhibited glioma cell proliferation, invasion and promoted apoptosis in vitro and restrained tumor growth in vivo, overexpression of LPP-AS2 resulted in the opposite effects. 32962742 circCPA4 CircRNA Homo sapiens Glioma glioma tissues regulation[miR-760/MEF2D Axis] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay e found circCPA4 was highly expressed in glioma, and circCPA4 knockdown suppressed tumor cell proliferative, migratory and invasive behaviors, but enhanced cell apoptosis and radiosensitivity in glioma. In conclusion, circCPA4 knockdown suppressed cell malignant phenotypes in glioma via miR-760/MEF2D axis to impede the progression of glioma, suggesting potential therapeutic targets for glioma treatment. Yes We found circCPA4 was highly expressed in glioma, and circCPA4 knockdown suppressed tumor cell proliferative, migratory and invasive behaviors, but enhanced cell apoptosis and radiosensitivity in glioma. 33068224 circELF2 CircRNA Homo sapiens Glioma GM tissues regulation[MiR-510-5p/MUC15 Signaling] CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay We observed that circ-ELF2 was significantly upregulated in GM tissues, which was analyzed by circRNA microarray and qRT-PCR.This study indicates that circ-ELF2/miR-510-5p/MUC15 signaling plays a key role in promoting the occurrence and development of GM. Upregulation of circ-ELF2 was associated with poor prognosis and high recurrence rate for GM patients after surgery. Yes The collapse of circ-ELF2 caused growth arrest and downregulation of cell migratory and invasive potential of GM cells and promoted cell apoptosis. In contrast, elevated expression of circ-ELF2 led to the opposite effect. 33116591 circVPS18 CircRNA Homo sapiens Glioma glioma tissues,cells regulation[MiR-370/RUNX1 Axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Circ-VPS18 expression and the mRNA and protein levels of RUNX1 were dramatically upregulated, and miR-370 expression was significantly downregulated in glioma cells, TMZ-resistant glioma tissues, or tissue compared with control groups.Circ-VPS18 knockdown improved TMZ sensitivity and repressed glioma progression by sponging miR-370 to downregulate RUNX1 expression, which provided a new insight in further studying glioma resistance to TMZ. Yes Functionally, circ-VPS18 knockdown improved TMZ sensitivity, induced cell apoptosis, whereas repressed cell viability, migration and invasion in U251/TR and LN229/TR cells, which was reversed by miR-370 inhibitor. 33188501 MALAT1 LncRNA Homo sapiens Pulmonary Arterial Hypertension PA tissues,cell lines Interaction[sponges miR‑124‑3p.1/KLF5] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay The results revealed that MALAT1 expression levels were significantly upregulated in the pulmonary arteries (PAs) and HPASMCs obtained from patients with PAH compared with adjacent normal PA tissues and HPASMCs. Bioinformatics analysis predicted complementary binding of hsa‑microRNA (miR)‑124‑3p.1 with the 3'‑untranslated region of MALAT1. Luciferase reporter assays and RNA immunoprecipitation experiments demonstrated molecular binding between MALAT1 and hsa‑miR‑124‑3p.1. This resulted in the formation of an RNA‑induced silencing complex. In addition, Kruppel‑like factor 5 (KLF5) was confirmed to be a target gene of MALAT1/hsa‑miR‑124‑3p.1. MALAT1 silencing did not inhibit the proliferation and migration of HPASMCs following knockdown of hsa‑miR‑124‑3p.1. In addition, MALAT1 knockdown was demonstrated to attenuate the expression of KLF5. Following MALAT1 knockdown, the expression level of KLF5 was rescued by inhibition of hsa‑miR‑124‑3p.1 expression. The results of the current study indicate that the MALAT1/hsa‑miR‑124‑3p.1/KLF5 axis may serve a key role in HPASMCs. Yes Knockdown of MALAT1 suppressed the viability and proliferation of HPASMCs and prevented cells entering the G0/G1 cell cycle phase. MALAT1 overexpression exerted the opposite effects. 31257528 MALAT1 LncRNA Homo sapiens Precursor Cell Lymphoblastic Leukemia-Lymphoma blood regulation[miR-205-PTK7 pathway] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay The levels of MALAT1 and PTK7 were upregulated in ALL samples. Our results suggest that MALAT1-miR-205-PTK7 axis participates in the proliferation and apoptosis of ALL, which may provide a potential treatment target for ALL. Yes Moreover, MALAT1 silencing or miR-205 overexpression restrained proliferation and promoted apoptosis of ALL cells. 32754978 MALAT1 LncRNA Homo sapiens Adrenal Cortex Neoplasms ACC tissues Interaction[miR-497-MALAT1/EIF4E] qRT-PCR//Luciferase Report Assay//RIP Recent contributions of high-throughput transcriptomic profiling identified microRNA-497 (miR-497) as significantly underexpressed, while lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) as overexpressed in ACC.Furthermore, MALAT1 directly binds to SFPQ (splicing factor proline and glutamine rich) protein, indicating its multifaceted roles in ACC pathophysiology. This is the first study to identify the feedback axis of miR-497-MALAT1/EIF4E in ACC tumourigenesis, providing novel insights into the molecular functions of noncoding RNAs in ACC. Yes We showed that overexpression of miR-497 and silencing of MALAT1 suppressed cellular proliferation and induced cell cycle arrest through downregulation of EIF4E expression. 31085769 circPTPRZ1 CircRNA Homo sapiens Glioma Regulation[MiR-1261/circ-PTPRZ1/PAK1 pathway ] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay Therefore, in glioma cells, the expression of circ-PTPRZ1/PAK1 is regulated by miR-1261, which affects the proliferation, apoptosis, and invasion. This finding provides another powerful evidence for the role of circRNAs in glioma. Yes Biological behaviors of glioma cells were detected, circ-PTPRZ1 enhanced cell proliferation and invasion, and inhibited cell apoptosis; miR-1261 had the opposite effects, and could terminate the above effects of circ-PTPRZ1. 31364003 MALAT1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues Interaction[sponging miR-195] qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay MALAT1, PD-L1 and CD8 were up-regulated in DLBCL tissues while miR-195 was down-regulated.MALAT1 could sponge miR-195 to regulate the expression of PD-L1. shMALAT1 treatment increased miR-195 level and decreased PD-L1 level. It also inhibited cell proliferation, migration and immune escape ability while increased apoptosis ratio of OCI-Ly10 cells. shMALAT1 treatment in OCI-Ly10 cells also promoted proliferation and inhibited apoptosis of CD8 T cells. Knocking down of MALAT1 also suppressed EMT-like process via Ras/ERK signaling pathway. These effects were all rescued by miR-195 inhibitor. + Yes shMALAT1 treatment increased miR-195 level and decreased PD-L1 level. It also inhibited cell proliferation, migration and immune escape ability while increased apoptosis ratio of OCI-Ly10 cells. 30898647 circHIPK3 CircRNA Homo sapiens Glioma cell lines Interaction[binding to miR-124-3p] CCK8//qRT-PCR//Flow Cytometry//EdU Staining QRT-PCR data showed that circ-HIPK3 and STAT3 are highly expressed, whereas miR-124-3p is lowly expressed in glioma cells than those of negative control cell. In summary, we found that overexpression of circ-HIPK3 promotes proliferative and invasive capacities of glioma cells by sponging miR-124-3p to upregulate STAT3 expression. Yes Knockdown of circ-HIPK3 in U87 and U251 cells inhibited their proliferative and invasive capacities. 30576808 hsa_circ_0034642 CircRNA Homo sapiens Glioma glioma tissues and cells Regulation[miR-1205/BATF3 axis] qRT-PCR//Luciferase Report Assay As the results demonstrated, hsa_circ_0034642 was boosted in glioma tissues and cells.Mechanistically, hsa_circ_0034642 sponges miR-1205. miR-1205 regulates BATF3 level through targeting its 3'-untranslated region. Overexpression of hsa_circ_0034642 was associated with clinical severity and poor prognosis. Yes What is more, elevated hsa_circ_0034642 strikingly facilitated cell proliferation, migratory and invasive capacities, and decreased apoptotic cells. 30938850 circZNF264 CircRNA Homo sapiens Glioma cell lines Interaction[miR-4493 ] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay Detection of circRNAs in glioma cells revealed that the expression of circ-ZNF264 was upregulated. Therefore, in glioma cells, circ-ZNF264 can inhibit the function of miR-4493 and then upregulate its target gene apelin expression, thus regulating glioma cell proliferation, apoptosis, and invasion. Yes Biological behaviors of glioma cells were detected; circ-ZNF264 promoted cell proliferation and invasion and inhibited apoptosis. 31114952 MALAT1 LncRNA Homo sapiens Pulmonary Disease, Chronic Obstructive Regulation(MALAT1/miR-146a/COX2 signaling axis.) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//ELISA we found that forced vital capacity, volume that has been exhaled at the end of the first second of forced expiration, and diffusion capacity for carbon monoxide were the highest in the MALAT1 HYPO + miR-146a HYPER group and lowest in the MALAT1 HYPER + miR-146a HYPO group, and COPD patients with hypermethylated MALAT1 showed lower expression of MALAT1 than that in the COPD patients with hypomethylated MALAT1. Meanwhile, miR-146a was the most significantly upregulated in the MALAT1 HYPER + miR-146a HYPO group and the most significantly downregulated in the MALAT1 HYPO + miR-146a HYPER group. Both prostaglandin E1 and cyclooxygenase 2 (COX2) expression were the highest in the MALAT1 HYPO + miR-146a HYPER group and the lowest in the MALAT1 HYPER + miR-146a HYPO group. In conclusion, our results established a MALAT1/miR-146a/COX2 signaling axis. The overexpression of MALAT1 could increase the expression of COX2 by inhibiting the expression of miR-146a, thus affecting the pulmonary function of COPD patients. Yes The overexpression of MALAT1 could increase the expression of COX2 by inhibiting the expression of miR-146a, thus affecting the pulmonary function of COPD patients. 34604205 hsa_circ_001350 CircRNA Homo sapiens Glioma Glioma Tissue,cell lines Interaction[sponges miR-1236] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Microarray//Transwell Assay circ_001350 level was significantly enhanced in glioma tissue specimens and cells. Collectively, circ_001350 directly sponges miR-1236, thus contributing to malignant progression of glioma. Yes Knockdown of circ_001350 could inhibit cell proliferation and metastatic properties and increase apoptotic cells. 31020693 circTTBK2 CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction[miR-520b/EZH2 axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The levels of circ-TTBK2 and EZH2 were markedly augmented, whereas miR-520b expression level was notably reduced in glioma tissues and cell lines.Circ-TTBK2/miR-520b/EZH2 axis modulated cell proliferation, apoptosis, and invasion in glioma cell lines, and might serve as potential targets for glioma diagnosis and therapy. Yes Either circ-TTBK2 or EZH2 detection could clearly facilitate cell apoptosis and block proliferation and invasion in A172 and U251 cells, while the effect of circ-TTBK2 or EZH2 deficiency was reverted by co-transfecting with miR-520 inhibitor. 31858557 MALAT1 LncRNA Homo sapiens Skin Neoplasms Regulation[MALAT1-KTN1-EGFR regulatory axis] qRT-PCR Further, MALAT1 was identified to regulate epidermal growth factor receptor (EGFR) protein expression but did not affect EGFR mRNA expression. Transcriptomic sequencing identified kinectin 1 (KTN1) as the key mediator for MALAT1 regulation of EGFR. Mechanistic study revealed that MALAT1 interacts with c-MYC to form a complex and directly binds to the promoter region of KTN1 gene and enhances its transactivation to positively regulate EGFR protein expression. Our findings, therefore, establish a novel c-MYC-assisted MALAT1-KTN1-EGFR axis, which contributes to cSCC development and may serve as novel target for therapeutic intervention. Yes In this study, functional studies using in vitro cellular and in vivo xenograft models confirmed the pro-carcinogenic roles of MALAT1 in cSCC. 30683916 MALAT1 LncRNA Homo sapiens Pre-Eclampsia placenta Regulation[ miR-206/IGF-1 axis] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that MALAT1 was decreased but miR-206 was increased in the placenta of patients with PE.Further, miR-206 was confirmed as a direct target of MALAT1. Besides, miR-206 inhibited IGF-1 expression by directly binding to the 3'UTR. Mechanistically, our study demonstrated that MALAT1 regulates IGF-1/PI3K/Akt signaling via miR-206. Together, these results suggest that MALAT1 and miR-206 play important roles in PE. MALAT1 regulates miR-206/IGF-1 axis, thereby modulating trophoblast cells migration and invasion through PI3K/Akt signal pathway. These results show light on the underlying mechanisms of PE and provide potential targets for PE therapy. Yes Inhibition of MALAT1, knockdown IGF-1, or miR-206 mimics suppressed the trophoblast cells migration and invasion, while overexpression of MALAT1, IGF-1 or miR-206 inhibitors exhibited opposite effects. 31774373 MALAT1 LncRNA Homo sapiens Pre-Eclampsia placenta of patients with severe preeclampsia Expression [lower expressed] Transfection//Tube Formation Assay//Immunoblotting//Migration Assay//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//Invasion Assay The expression of lncRNA MALAT1 was downregulated in the placenta of patients with severe preeclampsia. Moreover, MALAT1 inhibited the expression of angiogenic factors in umbilical vein endothelial cells co-cultured with trophoblasts. Yes MALAT1 smart silencer significantly inhibited HTR-8/SVneo trophoblast cell proliferation, invasion, migration and tube formation in vitro. 33547935 MALAT1 LncRNA Homo sapiens Coronary Artery Disease blood,cell line Regulation[mTOR signaling pathway] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay MALAT1 was overexpressed in CAD blood samples and EPCs. LncRNA MALAT1 inhibited EPCs autophagy and increased cell viability while repressed apoptosis of CAD via activating mTOR signaling pathway. Yes Knockdown of MALAT1 and MAPK1 promoted cell viability, autophagy and further suppressed the development of CAD. 30787203 circMAN2B2 CircRNA Homo sapiens Glioma glioma tissues,cell lines Regulation[miR-1205/S100A8 axis] CCK8//qRT-PCR//Transwell Assay In our study, we found that circMAN2B2 has a higher expression in glioma tissues and cells. In conclusion, circMAN2B2 could improve cell proliferation, invasion, and migration of the glioma by inhibiting miR-1205 and promoting the expression of S100A8. In our study, we found that circMAN2B2 has a higher expression in glioma tissues and cells, which was negatively related to the overall survival of glioma patients. Yes The cell counting kit-8 assay, 5-ethynyl-2'-deoxyuridine labeling assay, transwell assay, and the nude mice assay indicated that knockdown of circMAN2B2 inhibited the cell proliferation, invasion, migration and decreased tumor size. 31131447 circPITX52 CircRNA Homo sapiens Glioma glioma tissues,cell lines Interaction[sponging miR-518a-5p] qRT-PCR Quantitative reverse-transcription polymerase chain reaction was carried out to measure the expression of circ-PITX1, which was upregulated in matched cancerous tissues and adjacent noncancerous tissues from 52 patients and four cell lines of GM.What's more, circ-PITX1 sponges miR-518a-5p to release its repression on 3'-untranslated region (3'UTR) of interleukin 17 receptor D (IL17RD) messenger RNA to exert its oncogenic functions in GM cells proved by dual-luciferase reporter and rescue assays. Yes Gain and loss-of-function assays demonstrated that circ-PITX1 could facilitate the growth, migration, and invasion and inhibit cell apoptosis in GM cell lines. 31069865 hsa_circ_0000215 CircRNA Homo sapiens Glioma glioma tissues and cells interaction[Sponging miR-495-3p] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Circ_0000215 and CXCR2 were remarkably upregulated in glioma tissues and cells.These data demonstrated that circ_0000215 functions as a competitive endogenous RNA by sponging miR-495-3p, thus accelerating glioma progression through CXCR2 axis. Yes Overexpression of circ_0000215 notably promoted the proliferation, invasion and epithelial-mesenchymal transition (EMT) but inhibited apoptosis of glioma cells, while knocking down circ_0000215 had the opposite effects. 33089764 MALAT1 LncRNA Homo sapiens lung carcinoma lung carcinoma cells Interaction(miR-491-5p/UBE2C Axis) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay//Transwell Assay The results indicated that the expression of MALAT1 was often augmented in lung carcinoma cells. Collectively, MALAT1 downregulation suppressed lung carcinoma progression by regulating the miR-491-5p/UBE2C axis. Yes Suppression of MALAT1 blocked the proliferation, invasion and migration ability of cancer cells and inhibited the expression of UBE2C. UBE2C restoration attenuated the MALAT1 knockdown-induced anti-cancer effects. 34257576 hsa_circ_0079586 CircRNA Homo sapiens Glioma GM samples and cells regulation[miR-183-5p/ MDM4 Signaling Pathway] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay The expression of circ_0079586 was elevated in GM samples and cells and correlated with the clinical severity and unfavorable prognosis of the patients.In summary, circ_0079586 was found to be up-regulated in GM that increased the proliferation, migration and invasion in GM cells via interaction with the miR-183-5p/MDM4 axis. Yes The elevated expression of circ_0079586 led to an increase in cell growth, migration and invasion but inhibited apoptosis in U251 cells, whereas its down-regulation reversed these effects in the LN229 cells. 32606734 MALAT1 LncRNA Homo sapiens Endometriosis endometrium tissues regulation[PI3K/AKT pathway] qRT-PCR//MTT//Luciferase Report Assay//Western Blot Taken together, our study firstly demonstrates that MALAT1 regulates apoptosis of HESCs through miR-126-5p/CREB1 axis mediated PI3K/AKT pathway. Yes Knockdown of MALAT1 or CREB1 restrained proliferation and induced apoptosis as confirmed by upregulating cleaved caspase-3 and Bax, and down-regulating Bcl-2 in HESCs, while inhibition of miR-126-5p presented the opposite results. 32809092 circPTN CircRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-432-5p/RAB10 axis] Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay circ-PTN expression was enhanced and miR-432-5p abundance was reduced in glioma tissues and cells.circ-PTN knockdown repressed cell proliferation, invasion and glycolysis in glioma via modulating miR-432-5p and RAB10. Yes circ-PTN silence suppressed cell proliferation, invasion and glycolysis. 32629066 circABCB10 CircRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-620/FABP5 axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expression levels of circ-ABCB10 and FABP5 in glioma tissues and cells were significantly higher than those in their normal counterparts. These data suggest that circ-ABCB10 affects glioma progression by regulating the miR-620/FABP5 axis, and circ-ABCB10 might be used as a potential target for the treatment of glioma. Yes Silencing of circ-ABCB10 in glioma cells significantly inhibited the proliferation, migration and invasion of glioma cells. 32633377 MALAT1 LncRNA Homo sapiens Crohn Disease intestine mucosa of CD patients and mice Interaction(miR-146b-5p-CLDN11/NUMB Pathway) Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Microarray MALAT1 was aberrantly downregulated in the intestine mucosa of CD patients and mice with experimental colitis. MALAT1 regulated the intestinal mucosal barrier and regained intestinal homeostasis by sequestering miR-146b-5p and maintaining the expression of the AJC proteins NUMB and CLDN11. Yes MALAT1 knockout mice were hypersensitive to DSS-induced experimental colitis. 33677577 circFANCL CircRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-337-3p/HMGB1 signal axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay CircFANCL was signally increased in glioma tissues and cells, and the up-regulated circFANCL could predict poor prognosis in clinical glioma patients. Through the illustration of oncogenic function of circFANCL in glioma by the miR-337-3p/HMGB1 axis, we believed that circFANCL might be a great target in the early diagnosis and late treatment of glioma. CircFANCL was signally increased in glioma tissues and cells, and the up-regulated circFANCL could predict poor prognosis in clinical glioma patients. Yes Down-regulated circFANCL induced the proliferation inhibition, cell cycle arrest and apoptosis promotion of glioma cells in vitro, and inhibited tumor growth in vivo. 32683852 MALAT1 LncRNA Homo sapiens Diabetic Nephropathies DN tissues, HK-2 cells Interaction(LIN28A/Nox4/AMPK/TOR signaling) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//MTT//ELISA MALAT1, LIN28A and Nox4 were upregulated in DN tissues and HG-treated HK-2 cells. Furthermore, MALAT1 directly interacted with LIN28A. Moreover, MALAT1 facilitated the interaction between LIN28A and Nox4 to increase Nox4 stability. Knockdown of Nox4 relieved HG-induced injury by suppressing the AMPK/mTOR signaling in HK-2 cells. Knockdown of MALAT1 alleviated renal tubular epithelial injury by suppressing LIN28A and the Nox4/AMPK/TOR signaling in DN. Yes Overexpression of MALAT1, LIN28A or Nox4 reduced cell viability and enhanced cell apoptosis, ROS generation and secretion of inflammatory cytokines in HG-treated HK-2 cells, whereas knockdown of MALAT1, LIN28A or Nox4 exerted opposite effects. 35813614 MALAT1 LncRNA Homo sapiens Diabetes, Gestational Gestational diabetes mellitus placental tissues regulation[TGF-β/NF-κB signaling pathway] Western Blot//qRT-PCR//MTT//ELISA//Transwell Assay Gestational diabetes mellitus placental tissues showed higher lncRNA MALAT1 expression compared to a normal control group (p < 0.05). Downregulation of lncRNA MALAT1 inhibits inflammation and suppresses the proliferation, invasion and migration of GDM placental trophoblastic cells, possibly by modulating the TGF-β/NF-κB signaling pathway. Yes After siRNA intervention, lncRNA MALAT1 showed decreased expression in the trophoblastic layer; inhibited trophoblastic cell proliferation, migration, or invasion; decreased the secretion of inflammatory factors TNF-α and IL-6; and suppressed the expression of TGF-β and NF-κB compared to that of the control and siRNA-NC groups (p < 0.05). 32783409 circPOSTN CircRNA Homo sapiens Glioma glioma tissues and cells regulation[CircPOSTN/miR-361-5p/TPX2 axis ] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay CircPOSTN was overexpressed in glioma tissues and cells.Mechanistically, circPOSTN regulated cell growth, apoptosis, and aerobic glycolysis in glioma through miR-361-5p/TPX2 axis. Yes In vivo study revealed that deficiency of circPOSTN restrained tumor growth. 32774168 hsa_circ_0082374 CircRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-326/SIRT1] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We found circ0082374 expression was elevated in glioma tissues and cells. Collectively, silence of circ0082374 repressed the viability, migration, invasion and glycolysis in glioma cells by regulating miR-326 and SIRT1 in a ceRNA mechanism, providing a new mechanism for the pathogenesis of glioma. Yes Knockdown of circ0082374 suppressed the viability, migration, invasion and glycolysis in glioma cells. 32896523 circMMP1 CircRNA Homo sapiens Glioma exosomal regulation[circMMP1/miR-433/HMGB3 signaling] CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay The results showed that high serum exosomal circMMP1 level might predict poor prognosis of glioma patients.Targeting circMMP1/miR-433/HMGB3 signaling might be a novel insight for glioma treatment. The results showed that high serum exosomal circMMP1 level might predict poor prognosis of glioma patients. Yes CircMMP1 promoted the proliferation and motility and impeded the apoptosis of glioma cells.CircMMP1 silencing suppressed the progression of glioma in vivo. 32918539 MALAT1 LncRNA Homo sapiens laryngeal carcinoma cell lines Expression[highly expressed] CCK8//Cell Cycle Assay//qRT-PCR//Transwell Assay MALAT1 was significantly up-regulated in laryngeal and hypopharyngeal carcinoma cells. Yes MALAT1 down-regulation induced the increased apoptosis of both cell lines and suppressed cells' proliferation. Cells were arrested in G1/G2 phase and cells of S phase were significantly decreased. 31792655 MALAT1 LncRNA Homo sapiens gastric adenocarcinoma blood,cell lines Regulation[MALAT1/miR-181a-5p/AKT3 axis] CCK8//qRT-PCR//Western Blot Our results showed that MALAT1 was highly expressed in the serum of patients with gastric adenocarcinoma and in cell lines. Our research proposes a novel mechanism where the role of MALAT1 is dependent on the MALAT1/miR-181a-5p/AKT3 axis. Yes Downregulating MALAT1 inhibited proliferation and promoted apoptosis of MGC-803 cells. 31480991 MALAT1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical tumor cell lines Interaction(miR-124) In Vivo Experiment//qRT-PCR//Transfection//Cell Proliferation Assay We observed that miR-124 was the potential target of LncRNA MALAT1 in cervical tumor cell lines (Hela, C-33A, Caski, and SiHa), the expression level of which is negatively correlated with LncRNA MALAT1 in cervical tumor cells, tissues of cervical patients, and mice. In conclusion, LncRNA MALAT1 disabled the effects of miR-124 as an inhibitory sponge, accelerating the progression of cervical carcinoma. Yes Gain- or loss-of-function analyses in cervical tumor cells have further verified the regulatory role of MALAT1 on miR-124. Additionally, the proliferation of cervical carcinoma was inhibited by miR-124 overexpression, whereas it was blocked by LV-MALAT1 transfection. In vivo assays, overexpression of miR-124, or knockdown of MALAT1 exhibited beneficial effects on tumor weight, size, and volume, together with elevating the survival rate, tightly related with the progression of cervical cancer. 34221014 MALAT1 LncRNA Homo sapiens Polycystic Ovary Syndrome cell line Interaction(MDM2) Transfection//Immunoblotting//Flow Cytometry//FISH//qRT-PCR//Cell Proliferation Assay//IP//IF We identified that MALAT1 interacted with MDM2 and PARP1 in the cell nucleus. MDM2 binds to the 3' segment of MALAT1, containing the ENE domain through the ring finger domain. Yes Knockdown of MALAT1 in KGN cells and primary GCs increased apoptosis and reduced proliferation. 34883204 MALAT1 LncRNA Homo sapiens capillary hemangioma IH tissues Interaction[MEKK3/NF-κB pathway] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In IH tissues, MALAT1 and MEKK3 were overexpressed while miR-424 was down-regulated. Knockdown of MALAT1 suppressed the expression of MEKK3 and inactivated the IKK/NF-κB pathway by sponging miR-424. Overexpression of MEKK3 in HemEcs reversed the impact of knockdown of MALAT1 and overexpression of miR-424 on the cell proliferation, apoptosis, migration, invasion and tube formation rate. The tumor xenografts experiments demonstrated that silencing MALAT1 significantly inhibited the tumor growth in vivo and Ki-67 in the tumor tissues was also significantly suppressed. Yes Silencing MALAT1 or overexpression of miR-424 significantly inhibited the IH cell proliferation, migration and tube formation, but promoted the cell apoptosis. 31610202 MALAT1 LncRNA Homo sapiens capillary hemangioma IH tissues regulation[MiR-206 / VEGFA axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The results showed that MALAT1 and VEGFA were high-expressed and miR-206 was low-expressed in IH tissues. Knock-down of MALAT1 inhibits the growth of HemECs through regulating miR-206/VEGFA axis, indicating that MALAT1 is a potential therapeutic mechanism for the treatment of IH. Yes SiMALAT1 negatively affected the cell proliferation, migration, invasion and vasoformation of HemECs and promoted apoptosis of HemECs. 32084582 MALAT1 LncRNA Homo sapiens Laryngeal Neoplasms tissues and cell Interaction(miR-125b/HMGA1.) Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In laryngocarcinoma tissues and cells, lncRNA MALAT1 expression was significantly increased compared to normal tissues and cells.LncRNA MALAT1 upregulates HMGA1 expression by acting as a competitive endogenous RNA (ceRNA) for miR-125b. Rescue experiments showed that microRNA-125b inhibitor reversed the change in cell viability and invasion induced by sh-MALAT1. Down regulation of lncRNA MALAT1 inhibits laryngocarcinoma proliferation and invasion by modulating miR-125b/HMGA1. Yes LncRNA MALAT1 promotes proliferation and migration of laryngocarcinoma cells. 34183954 MALAT1 LncRNA Homo sapiens Laryngeal Neoplasms laryngocarcinoma cells Interaction(miR-708-5p/BRD4 ) In Vivo Experiment//Western Blot//Transfection//Migration Assay//CCK8//Flow Cytometry//qRT-PCR//Transwell Assay MALAT1 suppression inhibited the malignant phenotypes of laryngocarcinoma cells, such as decreased proliferation, promoted apoptosis, suppressed migration, and inhibited the CSC properties.Suppression of MALAT1 increased miR-708-5p expression and decreased the expression of BRD4 and YAP1 and inhibited EMT. Moreover, there were target relationships between MALAT1 and miR-708-5p as well as between miR-708-5p and BRD4. miR-708-5p overexpression and MALAT1 suppression had synergistic inhibitory effects on the malignant phenotypes of laryngocarcinoma cells and the expression of BRD4, YAP1, and EMT. Yes MALAT1 suppression inhibited the malignant phenotypes of laryngocarcinoma cells, such as decreased proliferation, promoted apoptosis, suppressed migration, and inhibited the CSC properties.Furthermore, in vivo experiments confirmed that MALAT1/miR-708-5p regulated tumorigenicity by regulating BRD4 and YAP1-mediated EMT. 35601153 circHIPK3 CircRNA Homo sapiens Glioma glioma tissues and cell lines interaction[sponging miR-124] CCK8//qRT-PCR//Transwell Assay Our results showed that circHIPK3 expression was significantly up-regulated in glioma tissues and cell lines. In summary, our results indicated that circHIPK3 had carcinogenic effects by regulating the expression of CCND2 in glioma by sponging miR-124. Yes In vitro, the down-regulation of circHIPK3 significantly inhibited the proliferation, migration and invasion of glioma cells. 33005182 MALAT1 LncRNA Homo sapiens Endometriosis endometriosis granulosa cells Interaction[ERK/MAPK pathway] qRT-PCR We first found that MALAT1 lncRNA was significantly down-regulated in endometriosis GCs and was associated with the antral follicle count (R = 0.376, P < 0.001 versus control).MALAT1 knockdown induced an increase in both the mRNA and protein levels of P21, and of P53, phosphorylated ERK1/2 (p-ERK1/2) and phosphorylated c-Jun N-terminal protein kinase (p-JNK) protein levels, as well as causing a decrease in cyclin dependent kinase 2 (CDK2), cyclin D1 and p-P38 MAPK protein levels. Furthermore, inhibition of the ERK/MAPK pathway with U0126, the up-regulation of p-ERK1/2, P21 and P53, and the down-regulation of CDK2 and cyclin D1 by the knockdown of MALAT1 were all attenuated by MALAT1 knockdown. Yes MALAT1 knockdown in KGN cells inhibited cell proliferation and cell-cycle progression. 30371869 hsa_circ_0001445 CircRNA Homo sapiens Glioma glioma cells Interaction(miRNA-127-5p/SNX5 pathway) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//RNA-seq//Invasion Assay//Transwell Assay The results demonstrated that exosomes derived from glioma cells promoted glioma progression. Also, exosomal circRNA 0001445 was taken up and upregulated in glioma cells treated with exosomes. In addition, exosomal circRNA 0001445 acted as a sponge for miRNA-127-5p to upregulate the expression of sorting nexin 5 (SNX5). Lastly, the effect of exosomal circRNA 0001445 was mediated by miRNA-127-5p/ SNX5 signaling pathway. Yes In addition, exosomal circRNA 0001445 acted as a sponge for miRNA-127-5p to upregulate the expression of sorting nexin 5 (SNX5). Lastly, the effect of exosomal circRNA 0001445 was mediated by miRNA-127-5p/ SNX5 signaling pathway. 33982667 MALAT1 LncRNA Homo sapiens Glioblastoma Regulation[MALAT1/miR-199a/ZHX1 Axis] FISH//RNA Pull-Down//Luciferase Report Assay//RIP Elevated ZHX1 expression correlated with poor prognosis in GBM patients, and in vitro studies demonstrated that ZHX1 attenuated GBM cell apoptosis by downregulation of pro-apoptotic protein (Bax) and upregulation of anti-apoptotic protein (Bcl-2). Finally, we demonstrated that MALAT1 promoted ZHX1 expression via acting as a competing endogenous RNA by sponging miR-199a. The MALAT1/miR-199a/ZHX1 axis promotes GBM cell proliferation and progression in vitro and in vivo, and its expression negatively correlates with GBM patient survival. Blocking the MALAT1/miR-199a/ZHX1 axis can serve as a novel therapeutic strategy for treating GBM. Yes Furthermore, knockdown of MALAT1 inhibited GBM proliferation and progression in vitro and reduced tumor volume and prolonged survival in an orthotopic GBM murine model. 31648104 MALAT1 LncRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-613) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//Cell Proliferation Assay//Transwell Assay The results of qRT-PCR showed that LncRNA MALAT1 was up-regulated and miR-613 was down-regulated in glioma tissues and cells, and LncRNA MALAT1 was negatively correlated with miR-613. Bioinformatics prediction and subsequent experiments proved that miR-613 was the direct target of LncRNA MALAT1. Yes Cell tests confirmed that LncRNA MALAT1 played a role in promoting oncogene, including promoting proliferation and invasion of glioma cells and promoting apoptosis. 34268963 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues Expression[highly expressed] CCK8//qRT-PCR//Wound Healing Assay//Invasion Assay MALAT1 expression was significantly increased in NSCLC samples compared with expression in adjacent non-cancerous tissues. Yes The proliferative, migratory and invasive abilities of MALAT1-silenced A549 cells were significantly decreased compared with those of control cells. 29805668 hsa_circ_0067934 CircRNA Homo sapiens Glioma glioma tissues and cells Interaction(microRNA miR-7/ Wnt/β-catenin axis) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay//IF The results of qRT-PCR indicated that circRNA_0067934 was over-expressed in glioma tissues, and down regulation of circRNA_0067934 reduced the tumor progression by inhibiting cell proliferation, invasion, and migration. In conclusion, our results revealed that circRNA_0067934 regulates glioma cells progression by targeting miR-7/ Wnt/β-catenin axis. Yes The results of qRT-PCR indicated that circRNA_0067934 was over-expressed in glioma tissues, and down regulation of circRNA_0067934 reduced the tumor progression by inhibiting cell proliferation, invasion, and migration. 35213267 hsa_circ_0001367 CircRNA Homo sapiens Glioma glioma tissues Interaction(miR-431/NRXN3 axis) In Vivo Experiment//IHC//Western Blot//Transfection//qRT-PCR//RIP//FISH//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In this study, we found that circ_0001367 was downregulated in glioma tissues and showed a close correlation with glioma patient survival. Functional assays demonstrated that upregulation of circ_0001367 could suppress the proliferation, migration and invasion of glioma cells in vitro and inhibit glioma growth in vivo. Furthermore, bioinformatics analysis, luciferase reporter assay and RNA immunoprecipitation assay indicated that circ_0001367 can serve as a sponge for miR-431 and that miR-431 acts as an oncogene by regulating neurexin 3 (NRXN3). In addition, rescue experiments verified that circ_0001367 could regulate both the expression and function of NRXN3 in a miR-431-dependent manner. we found that circ_0001367 was downregulated in glioma tissues and showed a close correlation with glioma patient survival. Yes Functional assays demonstrated that upregulation of circ_0001367 could suppress the proliferation, migration and invasion of glioma cells in vitro and inhibit glioma growth in vivo. Furthermore, bioinformatics analysis, luciferase reporter assay and RNA immunoprecipitation assay indicated that circ_0001367 can serve as a sponge for miR-431 and that miR-431 acts as an oncogene by regulating neurexin 3 (NRXN3). 34035217 hsa_circ_0001017 CircRNA Homo sapiens Glioma glioma tissue and cells Interaction(let-7g-3p/NDST3 axis) Western Blot//Transfection//Wound Healing Assay//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay In glioma tissues and cells, hsa_circ_0001017 expression was decreased. The overexpression of hsa_circ_0001017 inhibited glioma cell proliferation, EMT, migration, and invasion and promoted glioma cell apoptosis, while the knockdown of hsa_circ_0001017 caused the opposite results. Mechanistically, hsa_circ_0001017 sponged hsa-let-7g-3p and NDST3 was the target gene of hsa-let-7g-3p. Moreover, the tumour-suppressive role of circ_0001017 was associated with hsa-let-7g-3p and NDST3. Yes The overexpression of hsa_circ_0001017 inhibited glioma cell proliferation, EMT, migration, and invasion and promoted glioma cell apoptosis, while the knockdown of hsa_circ_0001017 caused the opposite results. 34284545 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-613/COMMD8 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay MALAT1 and COMMD8 were aberrantly upregulated in NSCLC tissues and cells.MALAT1 promoted malignant activities of NSCLC cells through targeting miR-613/COMMD8 axis, and exosome-mediated transfer of NSCLC might be a novel approach for NSCLC treatment. Yes MALAT1 or COMMD8 knockdown blocked cell proliferation, colony formation and glycolysis but accelerated cell apoptosis in vitro. Besides, MALAT1 knockdown reduced tumor growth in vivo. 33149680 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-185-5p/MDM4 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay We found MALAT1 and MDM4 were upregulated and MALAT1 positively regulated the MDM4 expression. Collectively, MALAT1 contributed to proliferation, migration, invasion, and impeded apoptosis by regulating the MDM4 expression mediated by miR-185-5p in NSCLC cells. Besides, knockdown of MALAT1 inhibited tumor growth in vivo through miR-185-5p/MDM4 axis in NSCLC. Yes MALAT1 and MDM4 deletion significantly hindered the proliferation, metastasis, and expedited the apoptosis of NSCLC cells. Besides, knockdown of MALAT1 inhibited tumor growth in vivo through miR-185-5p/MDM4 axis in NSCLC. 33146951 circBRAF CircRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-1290/FBXW7 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay Expression of circBRAF and FBXW7 was decreased in glioma tissues and cells. MiR-1290 was upregulated in glioma, which was sponged by circBRAF. Besides, circBRAF elevated FBXW7 expression by targeting miR-1290. Introduction of miR-1290 or FBXW7 knockdown could counteract the inhibitory effects of circBRAF upregulation on the malignant phenotypes of glioma cells. Yes Upregulation of circBRAF inhibited glioma cell proliferation and metastasis in vitro. Overexpression of circBRAF repressed the tumor growth in vivo. 33650075 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung serum and cell exosomes regulation[miR-515-5p/EEF2 Axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay MALAT1 was highly expressed in serum and cell exosomes from NSCLC patients. MALAT1 knockdown repressed NSCLC tumorigenicity by inhibiting cell proliferation, invasion and promoting apoptosis through regulating miR-515-5p/EEF2, besides, MALAT1 was highly enriched in exosomes of NSCLC, suggesting a possible molecular-targeted therapy for NSCLC patients. Yes MALAT1 knockdown repressed cell proliferation, invasion and induced cell apoptosis in vitro as well as inhibited tumor growth in vivo in NSCLC. 32943920 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC clinical tissues & NSCLC cell lines Interaction(MALAT1/microRNA-503-5p/SEPT2 axis) ChIP//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Augmented JMJD2C, MALAT1, and SEPT2 and reduced miR-503-5p levels were found in NSCLC. Depleting JMJD2C or MALAT1, or restoring miR-503-5p exerted anti-tumor effects on NSCLC cells in vitro and in vivo. JMJD2C is bound to the promoter of MALAT1. MALAT1 bound to miR-503-5p and miR-503-5p targeted SEPT2. Knocking down MALAT1 or SEPT2, or elevating miR-503-5p mitigated the pro-tumor effects of upregulated JMJD2C on NSCLC. It is evident that the JMJD2C-mediated MALAT1/miR-503-5p/SEPT2 axis takes part in the process of NSCLC and even worsens NSCLC. Yes Knocking down MALAT1 or SEPT2, or elevating miR-503-5p mitigated the pro-tumor effects of upregulated JMJD2C on NSCLC. 35046387 circTOP2A CircRNA Homo sapiens Glioma GM tissue specimens and cells Interaction(miR-346/SUSD2 signaling) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The present study demonstrated that circ-TOP2A was elevated in GM tissue specimens and cells and that circ?TOP2A levels indicated an unfavorable clinical prognosis in GM. Circ‑TOP2A acted as a competing endogenous RNA to upregulate sushi domain‑containing 2 (SUSD2) expression by sponging microRNA (miR) 346. The present study demonstrated that circ?TOP2A was elevated in GM tissue specimens and cells and that circ?TOP2A levels indicated an unfavorable clinical prognosis in GM. Yes Functionally, circ?TOP2A knockdown reduced viability, migration and invasion and triggered apoptosis in LN229 cells. 33537815 MALAT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cell lines Interaction[YAP ] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay In this study, we found that MALAT1 expression was remarkably increased in ESCC cells compared to normal human esophageal epithelial cells. We also established that MALAT1 binds directly to Yes-associated protein (YAP), thereby enhancing YAP protein expression and increasing YAP transcriptional activity. Overexpression of YAP partially rescued the effect of MALAT1 knockdown on stemness and radiosensitivity of ESCC cells. Overall, this study has identified that a novel MALAT1-YAP axis promotes the stemness of ESCC cells, and thus could be a potential target for treatment of ESCC. Yes In addition, knockdown of MALAT1 attenuated the stemness of ESCC cells, as evidenced by a decrease in spheroid formation capacity, stemness marker expression and aldehyde dehydrogenase 1 activity. Moreover, MALAT1 knockdown decreased the migration ability of ESCC cells. Notably, knockdown of MALAT1 enhanced the radiosensitivity and chemosensitivity of ESCC cells. 31116509 hsa_circ_0007534 CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction( miR-22-3p/PROX1 ) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Circ_0007534 was highly expressed in glioma tissues and cell lines relative to that in normal tissues and NHA cell line. . Circ_0007534 negatively regulated miR-22-3p level through targeting it in glioma cells. Circ_0007534 interference-induced influences in glioma cells were partly overturned by the silencing of miR-22-3p. PROX1 was a target of miR-22-3p, and circ_0007534 interference-mediated effects in glioma cells were largely diminished by the overexpression of PROX1. Yes Circ_0007534 knockdown suppressed the proliferation and motility while induced the apoptosis of glioma cells. Circ_0007534 interference restrained glioma development in vivo. 34536179 hsa_circ_0091581 CircRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-1243-5p/RMI1 ) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay This study demonstrated that hsa_circ_0091581 is upregulated in glioma tissues and cells. The results of the luciferase reporter and RNA immunoprecipitation assays indicated that the mechanism of the effects of hsa_circ_0091581 on glioma cells involves sponging miR-1243-5p to regulate RMI1. Yes The results of the CCK-8, EdU, and transwell assays indicated that hsa_circ_0091581 promotes proliferation, migration, and invasion of glioma cells. 33976734 circCREBBP CircRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-375/glutaminase axis) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ-CREBBP was highly expressed in glioma tissues and cells, and high expression of circ-CREBBP predicted poor prognosis. Mechanistically, circ-CREBBP indirectly regulated GLS expression through sponging miR-375. In all, circ-CREBBP expedited glioma tumorigenesis and glutamine metabolism through miR-375/GLS axis, suggesting a promising target for combined glioma therapy. Circ-CREBBP was highly expressed in glioma tissues and cells, and high expression of circ-CREBBP predicted poor prognosis. Yes Circ-CREBBP knockdown suppressed cell proliferation, migration, invasion and glutamine metabolism while expedited cell apoptosis in glioma in vitro, as well as impeded tumor growth in vivo. 34813772 MALAT1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues,cell lines Interaction[sponging miR-363-3p] qRT-PCR//Luciferase Report Assay//Western Blot We observed that MALAT1 was highly expressed in colorectal cancer tissues and cells.Moreover, miR-363-3p functions as a downstream target of MALAT1, meanwhile EZH2 was a target of miR-363-3p, suggesting MALAT1 might regulate miR-363-3p and/or EZH2 expression. Collectively, we concluded that MALAT1 functioned as a ceRNA to promote colorectal cancer development and EZH2 expression through sponging miR-363-3p in vitro and in vivo. Yes We observed that MALAT1 was highly expressed in colorectal cancer tissues and cells, and MALAT1 knockdown inhibited cell proliferation as well as expression levels of EZH2 by upregulated miR-363-3p in cell models and in vivo. 30972996 circNCAPG CircRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-200a-3p/RAB5A axis) Cell Proliferation Assay Expression of circNCAPG and RAB5A was upregulated, and miR-200a-3p was decreased in glioma tissues and cells, while their expression presented an opposite trend in Pro-treated glioma cells. Mechanically, circNCAPG could regulate RAB5A expression by sponging miR-200a-3p. Pro blocked glioma tumor growth in vivo by modulating circNCAPG. Yes Moreover, circNCAPG overexpression could abolish Pro-mediated proliferation, apoptosis, migration, and invasion in glioma cells in vitro. 34129971 circUBAP2 CircRNA Homo sapiens Glioma glioma tissues Interaction(miR-1205 or miR-382 /GPRC5A ) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay Circ-UBAP2 expression was upregulated in glioma. Mechanistically, circ-UBAP2 directly bound to miR-1205 and miR-382. miR-1205 and miR-382 mediated the regulation of circ-UBAP2 silencing on glioma cell behaviors. Moreover, GPRC5A was a functional target of miR-1205 and miR-382 in regulating glioma cell behaviors.Furthermore, circ-UBAP2 mediated GPRC5A expression through miR-1205 or miR-382 in glioma cells. Yes The reduced level of circ-UBAP2 hampered cell proliferation, migration, invasion, and enhanced apoptosis in vitro and weakened tumor growth in vivo. 33543830 circEGFR CircRNA Homo sapiens Glioma glioma samples Interaction(miR-183-5p/TUSC2 Axis) In Vivo Experiment//Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The qRT-PCR showed the downregulation of circ-EGFR and TUSC2 but the upregulation of microRNA-183-5p (miR-183-5p) in glioma samples. Circ-EGFR was identified as a sponge of miR-183-5p and circ-EGFR-mediated glioma progression inhibition was abolished by miR-183-5p downregulation. Additionally, miR-183-5p targeted TUSC2 and miR-183-5p inhibitor impeded the development of glioma by upregulating the expression of TUSC2. Furthermore, circ-EGFR could regulate the TUSC2 level by sponging miR-183-5p. Glioma growth in vivo was also reduced by circ-EGFR via targeting the miR-183-5p/TUSC2 axis. Yes In vitro assays revealed that circ-EGFR overexpression induced the repression of cell proliferation, migration, and invasion but the promotion of apoptosis. 33993369 MALAT1 LncRNA Homo sapiens Colorectal Neoplasms cell lines Expression[highly expressed] qRT-PCR We observed increased expression of MALAT1 in six CRC cell lines compared to that in normal cells, suggesting its involvement in CRC progression. Yes Downregulation of MALAT1 inhibited cell migration and induced apoptosis in vitro and inhibited tumor growth and metastasis in nude mice. 30716387 circTLK1 CircRNA Homo sapiens Glioma glioma tissues Interaction(miR-17-5p-PANX1 ) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Transwell Assay We found that Circ-TLK1 was conspicuously up-regulated in glioma tissues compared with adjacent normal tissues, and the up-regulated Circ-TLK1 was significantly correlated with glioma patients' larger tumor volume and higher grades. In addition, bioinformatics analysis showed that miR-17-5p was a potential target of Circ-TLK1 and targeted at PANX1. Furthermore, through dual luciferase viability assay, Circ-TLK1 acted as a competing endogenous RNA by sponging miR-17-5p, which targeted and inhibited PANX1/MAPK/ERK expression. We found that Circ-TLK1 was conspicuously up-regulated in glioma tissues compared with adjacent normal tissues, and the up-regulated Circ-TLK1 was significantly correlated with glioma patients' larger tumor volume and higher grades. Yes Functionally, Circ-TLK1 over-expression facilitated glioma growth, migration and invasion, inhibited cell apoptosis, and accelerated PANX1/MAPK/ERK expression, while Circ-TLK1 low expression had the opposite effects. 34181173 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[miR-200a-3p/PDL1 axis ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay In this study, we demonstrated that in NSCLC tissues, the expression level of MALAT1 was negatively correlated with that of miR-200a-3p, while positively correlated with PD-L1. Besides, MALAT1 promoted proliferation, mobility, migration, and invasion of NSCLC cells via sponging miR-200a-3p. PD-L1 was validated as a target of miR-200a-3p, and indirectly modulated by MALAT1. Yes Subsequently, CCK8 assay were conducted. The proliferation rate of CAL-12T cells with low-expressed MALAT1 significantly decreased than that of the control groExpression[Expression[up-expression]-expression], and the proliferation of CAL-12T cells with lowly expressed MALAT1 significantly increased after transfection of miR-200a-3p inhibitors (Figure 3(d)). 31240979 hsa_circ_0008344 CircRNA Homo sapiens Glioma glioma tumors and cells Interaction(miR-638/SZRD1 Pathway) In Vivo Experiment//Bioinformatics Analysis//Transfection//Tube Formation Assay//qPCR//CCK8//Luciferase Report Assay//EdU Staining//Transwell Assay Abundances of circ_0008344 and SUZ RNA binding domain containing 1 (SZRD1) were highly elevated, while miR-638 was downregulated in glioma tumors and cells. Circ_0008344 might contribute to glioma progression through miR-638/SZRD1 axis, which might be a novel pathology and treatment target in glioma. Yes Circ_0008344 was identified as a stable circRNA with a circular structure. Silencing circ_0008344 could restrain glioma proliferation, migration, invasion, and angiogenesis. Also, circ_00008344 knockdown suppressed glioma tumor growth. 35394558 MALAT1 LncRNA Homo sapiens Glioma glioma tissues and cells Interaction( miR-124) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//MTT//Cell Apoptosis Assay//Cell Cycle Assay//IHC In the present study, we found that the expression of MALAT1 was aberrantly increased in both human glioma tissues and cells and associated with poor prognosis in glioma patients. In the present study, we found that the expression of MALAT1 was aberrantly increased in both human glioma tissues and cells and associated with poor prognosis in glioma patients. Yes We further found that MALAT1 silencing significantly inhibited glioma cell proliferation while induced cell cycle arrest and apoptosis. In parallel, knockdown of MALAT1 decreased tumor volume in vivo. 33078370 hsa_circ_0000285 CircRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-197-3p/CKS1B axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay We noted that circ_0000285 was highly expressed in glioma tissues and cells and that circ_0000285-silencing retarded tumor growth both in vitro and in vivo. This effect was mediated by the binding of circ_0000285 to miR-197-3p, which silenced CKS1B, an essential driver of glioma cell proliferation and invasion. Yes We noted that circ_0000285 was highly expressed in glioma tissues and cells and that circ_0000285-silencing retarded tumor growth both in vitro and in vivo. 35174774 MANCR LncRNA Homo sapiens Lymphoma, Mantle-Cell blood Interaction[RUNX2] qRT-PCR We found that serum MANCR and Runt-related transcription factor 2 (RUNX2) were upregulated in MCL patients when compared with those in healthy controls. Therefore, we conclude that downregulation of MANCR may inhibit cancer cell proliferation in MCL possibly by interacting with RUNX2. Yes MANCR overexpression promoted the proliferation of MCL cells, while MANCR silencing inhibited the proliferation of MCL cells. 31650163 hsa_circ_0076931 CircRNA Homo sapiens Glioma NBT tissues and cells Interaction(miR-6760-3p/CCBE1) cell invasion assay//qRT-PCR//migration assay Hsa_circ_0007694 and hsa_circ_0008016 were memorably increased whereas hsa_circ_0076931 and hsa_circ_0076948 decreased in glioma compared with those in NBT. In addition, elevated hsa_circ_0076931 levels induced the expression of CCBE1 while suppressing miR-6760-3p expression. miR-6760-3p can bind to hsa_circ_0076931. Additionally, hsa_circ_0076931 expression was negatively correlated with histological grade. Yes Overexpression of hsa_circ_0076931 inhibited proliferation, migration, and invasion while promoting apoptosis of glioma cells. 34931668 MALR LncRNA Homo sapiens Esophageal Neoplasms ESCC cells Interaction(ILF3) qRT-PCR//RNA Pull-Down TAM-mediated secretion of TNFα drove MALR upregulation in ESCC cells. Mechanistically, MALR bound the dsRBD1 domain of interleukin enhancer-binding factor 3 (ILF3), promoting ILF3 protein stability and ILF3-mediated liquid–liquid phase separation (LLPS), thereby enhancing HIF1α mRNA stability by preventing PARN-mediated degradation. Clinically, high expression of MALR positively correlated with HIF1α target gene expression and indicated poor prognoses for patients with esophageal cancer. Yes MALR promoted aerobic glycolytic activity and facilitated angiogenesis by activating the HIF1α signaling pathway. Loss of MALR suppressed cell line–based and patient-derived xenograft tumor growth. 36264156 MALINC1 LncRNA Homo sapiens Breast Neoplasms breast cancer cells Regulation Cell Proliferation Assay//qRT-PCR//RNA-seq//Migration Assay We determined that MALINC1 is an estrogen-estrogen receptor-modulated lncRNA enriched in the cytoplasmic fraction of luminal A/B breast cancer cells that is associated with worse overall survival in patients with primary invasive breast carcinomas. We determined that MALINC1 is an estrogen-estrogen receptor-modulated lncRNA enriched in the cytoplasmic fraction of luminal A/B breast cancer cells that is associated with worse overall survival in patients with primary invasive breast carcinomas. Yes We determined that MALINC1 induces premalignant phenotypic changes by increasing cell migration in normal breast cells. Moreover, high MALINC1 expression in invasive carcinomas was associated with a pro-tumorigenic immune environment and a favorable predicted response to immunotherapy both in luminal and basal-like subtypes compared with low-MALINC1-expression tumors. 35740485 MALAT2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cell lines Expression[highly expressed] CCK8//Cell Cycle Assay//qRT-PCR//Transwell Assay MALAT1 was significantly up-regulated in laryngeal and hypopharyngeal carcinoma cells. Yes MALAT1 down-regulation induced the increased apoptosis of both cell lines and suppressed cells' proliferation. Cells were arrested in G1/G2 phase and cells of S phase were significantly decreased. 31792655 MALAT1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction[PI3K/AKT pathway] CCK8//qRT-PCR//Western Blot//Transwell Assay In the present study, MALAT1 expression was significantly upregulated in gastric tumors compared with adjacent healthy tissue in patients with gastric cancer. Furthermore, MALAT1 plasma expression was higher in patients with gastric cancer compared with healthy controls and was found to have prognostic and diagnostic value independent of patients' lifestyle choices. Yes Cell proliferation assay and Transwell migration and invasion results indicated that the overexpression of MALAT1 resulted in increased proliferation, migration and invasion of gastric cancer cells in vitro, possibly through activation of the phosphoinositide 3-kinase/protein kinase B pathway. 31186750 MALAT1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction[downregulating microRNA-204 ] qRT-PCR//MTT//Colony Formation Assay//Western Blot To the best of our knowledge, the present study was the first to demonstrate that upregulated MALAT1 was associated with increased autophagy activation in GC tissues.In addition, the results revealed that MALAT1 inhibited microRNA (miR)-204 expression in GC cells. The present study also demonstrated that miR-204 repressed autophagy through the downregulation of LC3B and transient receptor potential melastatin 3 expression in GC cells. These results indicated that MALAT1 activated autophagy and promoted cell proliferation by downregulating miR-204 expression in GC. Yes Furthermore, this study reported that MALAT1 increased cell proliferation and enhanced autophagy activation in GC cells. 31897197 MALAT1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] Western Blot//Flow Cytometry//qRT-PCR//CCK8//Colony Formation Assay//Transwell Assay Higher expression of MALAT1 was detected in GC tissues than that of adjacent normal tissues, high MALAT1 expression is an independent risk for overall survival of gastric cancer patients. Higher expression of MALAT1 was detected in GC tissues than that of adjacent normal tissues, high MALAT1 expression is an independent risk for overall survival of gastric cancer patients. Yes Knockdown of MALAT1 inhibited proliferation, migration and invasion of GC cells, while overexpression of MALAT1 Overexpression of MALAT1 yielded opposite results. 32214850 MALAT1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[microRNA-22-3p-Mediated ErbB3] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay MALAT1 was significantly upregulated in GC tissues and cells and negatively associated with the survival of GC patients.Silencing of MALAT1 inhibited the proliferation and promoted the apoptosis of GC cells through upregulating miR-22-3p and downregulating ErbB3. MALAT1 was significantly upregulated in GC tissues and cells and negatively associated with the survival of GC patients. Yes Overexpression of MALAT1 significantly promoted the proliferation and inhibited the apoptosis of SGC-7901 cells, while silencing of MALAT1 exerts contrary effects on BGC-823 cells. Silencing of MALAT1 also significantly inhibited the tumor growth in mice. 32021298 hsa_circ_0001982 CircRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-1205/E2F1 axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Circ_0001982 expression level was increased in glioma tissues and correlated with larger tumor size. Circ_0001982 directly targeted miR-1205, and miR-1205 directly targeted E2F1. Besides, circ_0001982 could up-regulate E2F1 expression via repressing miR-1205 expression. Circ_0001982 expression level was increased in glioma tissues and correlated with larger tumor size. Yes Circ_0001982 overexpression enhanced glioma cell proliferation, migration, and invasion, and accelerated cell cycle progression while knocking down circ_0001982 exerted opposite effects. 35994229 MALAT1 LncRNA Homo sapiens Breast Neoplasms BC tissue Regulation[miR-145] qRT-PCR To investigate the role of MALAT1 in human BC progression, we detected MALAT1 expression levels based on tissue samples from 20 BC cases and 20 healthy controls and found MALAT1 expression levels to be significantly high (P<0.05). This outcome revealed that MALAT1 promoted angiogenesis in BC, which may be related to the expression of miR‑145. Yes The results revealed that MALAT1 knockdown could significantly inhibit proliferation, migration, and tube formation in vitro. 30226550 circNEIL3 CircRNA Homo sapiens Glioma glioma tissues and cells Interaction(IGF2BP3 ) Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay We identified circNEIL3, which could be cyclized by EWS RNA-binding protein 1(EWSR1), to be upregulated in glioma tissues and to correlate positively with glioma malignant progression.Mechanistically, circNEIL3 stabilizes IGF2BP3 (insulin-like growth factor 2 mRNA binding protein 3) protein, a known oncogenic protein, by preventing HECTD4-mediated ubiquitination. Moreover, circNEIL3 overexpression glioma cells drives macrophage infiltration into the tumour microenvironment (TME). Yes Functionally, we confirmed that circNEIL3 promotes tumorigenesis and carcinogenic progression of glioma in vitro and in vivo. 35031058 circABCC1 CircRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-591/HMGA2 signaling) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//FISH//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//H&E Staining//Cell Proliferation Assay//Transwell Assay CircABCC1 was highly expressed, and miR-591 was downregulated in glioma tissues and cells.Through the ceRNA mechanism, circABCC1 interacts with miR-591 to regulate the expression of HMGA2. CircABCC1 functions as an oncogene to promote the progression of glioma via the regulation of miR-591/HMGA2 signaling. Yes Suppression of circABCC1 repressed the malignant behaviors of glioma cells and tumor growth. 35000195 hsa_circ_0001588 CircRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-1281/ERBB4 pathway) In Vivo Experiment//IHC//Western Blot//Transfection//Tube Formation Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Colony Formation Assay//Transwell Assay Circ_0001588 and ERBB4 expressions were significantly upregulated, while miR-1281 was downregulated in glioma tissues and cells compared with control groups.Decreased expression of circ_0001588 in glioma cells led to significant decreases of cell proliferation, migration, invasion, and tube formation and an increase of cell apoptosis. Circ_0001588 expression was closely related to tumor size and WHO grade of glioma. Yes Decreased expression of circ_0001588 in glioma cells led to significant decreases of cell proliferation, migration, invasion, and tube formation and an increase of cell apoptosis. Furthermore, circ_0001588 depletion suppressed tumor formation in vivo. 34982356 MALAT1 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR//MTT//Transwell Assay MALAT1 was highly expressed in BC tissues compared with normal tissues adjacent to cancer as well as in BC cells. Yes In addition, inhibition the expression of MALAT1 could significantly suppress the proliferation, migration and invasion of BC cells. 35410813 hsa_circ_0008922 CircRNA Homo sapiens Glioma glioma tissues Expression(highly expressed) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RNA-seq//Bioinformatics Analysis//Transwell Assay We found that the expression of hsa_circ_0008922 in glioma tissues was 3.4 times higher than that in normal tissues. The expression of has_circ_0008922 was correlated with WHO tumor grade. Yes After down-regulating the expression of hsa_circ_0008922, malignant biological behavior of glioma cells was inhibited, such as cell proliferation, colony formation, migration, and invasion. At the same time, it also induced apoptosis of glioma cells. 36570001 MALAT1 LncRNA Homo sapiens Breast Neoplasms 36 pairs of breast cancer and adjacent tissues Interaction(miR‑26a/26b/ST8SIA4 axis) Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Invasion Assay//IF Upregulated MALAT1 was a crucial predictor of poor breast cancer prognosis. Altered MALAT1 modulated cell progression in breast cancer. Moreover, miR‑26a/26b was confirmed as a direct regulator of MALAT1, and ST8SIA4 was predicted as a target of miR‑26a/26b. Yes Functional analysis in human breast cancer cell lines demonstrated that MALAT1 modulated breast cancer cell tumorigenicity by acting as a competing endogenous lncRNA (ceRNA) to regulate ST8SIA4 levels by sponging miR‑26a/26b. 34278507 MALAT1 LncRNA Homo sapiens Breast Neoplasms 71 intraoperative tumor specimens from BC patients and matched normal specimens Interaction(miR101-3p/mTOR/PKM2 pathway ) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The MALAT1 overexpressions in the BC tissues and cells were considered to be a predictor of poor prognosis. MALAT1 was anticipated to be an miR-101-3p target according to the dual-luciferase reporter gene assay results. Additionally, the mTOR/PKM2 pathway was directly targeted by miR-101-3p. Yes Therefore, MALAT1 downregulation significantly inhibited BC progression, including cell growth, invasion, and migration.  34650695 MALAT1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues interaction[sponging miR-508-5p] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, we reported that MALAT1 expression is significantly upregulated in CRC and correlated with advanced TNM stage, lymph node metastasis, and worse prognosis in patients. Collectively, our findings indicated that MALAT1 could promote CRC progress by sponging miR-508-5p and enhancing RAB14 expression, which provides a therapeutic target in CRC treatment. In the present study, we reported that MALAT1 expression is significantly upregulated in CRC and correlated with advanced TNM stage, lymph node metastasis, and worse prognosis in patients. Yes Functional assays revealed that MALAT1 knockdown reduced CRC cell growth and invasion abilities in vitro. 33344634 circHECTD1 CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-296-3p/SLC10A7 axis) In Vivo Experiment//Transfection//qRT-PCR//RIP//RNA-seq//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay Then we confirmed that the level of circHECTD1 was significantly increased both in glioma tissues and cell lines, which is negatively correlated with the overall survival of patients. Luciferase reports and RNA immunoprecipitation data indicated that miR-296-3p was a direct target of circHECTD1 and that the miR-296-3p expression negatively regulated SLC10A7. Rescue experiments showed that the overexpression of SLC10A7 could impede the effects of circHECTD1 silencing on the proliferation and invasion of glioma cells. Then we confirmed that the level of circHECTD1 was significantly increased both in glioma tissues and cell lines, which is negatively correlated with the overall survival of patients. Yes Knockdown of circHECTD1 inhibited proliferation and invasion in vitro, and also reduced the growth of tumor and prolonged the prognosis in vivo. Knockdown of circHECTD1 significantly elevated the miR-296-3p expression in LN229 and T98G cells. 33561315 circGFRA1 CircRNA Homo sapiens Glioma glioma specimens Interaction(miR-99a) Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay The results showed that circGFRA1 expression was overexpressed in glioma specimens. Moreover, circGFRA1 acts as a microRNA sponge for miR-99a. Furthermore, miR-99a was involved in the circGFRA1-regulated glioma cell behaviors. Silencing circGFRA1 reduced p/t-AKT, p/t-FOXO1 and p/t-mTOR expression levels via upregulating miR-99a expression. Yes Knockdown circGFRA1 declined viability, colony formation, proliferation and migrative potential, but enhanced U251 cell apoptosis. 33994521 MALAT1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues regulation[miR-21] qRT-PCR//Wound Healing Assay//Transwell Assay Compared with paracancerous tissues, MALAT1 expression was significantly increased in colon cancer tissues.MALAT1 can regulate miR-21 to regulate the migration and invasion of colon cancer cells. Yes Inhibition of MALAT1 could inhibit colon cancer cell invasion and migration ability, and tumor formation in nude mice showed that the tumor volume and weight of the tumor-bearing mice were reduced after inhibiting the expression of MALAT1. 32521885 MALAT1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC and matched adjacent non-tumor tissues，cell lines (HT-1376, RT112, 253J and T24) Interaction[miR‑34a;CCND1] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot As indicated in Fig. 1A, the expression levels of MALAT1 were significantly increased in the BC tissues compared with the adjacent non-tumour tissues. The expression of MALAT1 in the BC cell lines (HT-1376, RT112, 253J and T24) and the normal urinary tract epithelial cell line SV-HUC-1 were also assessed. MALAT1 was also significantly Expression[Expression[up-expression]-expression]regulated in the BC cell lines compared with the SV-HUC-1 cells (Fig. 1D). knockExpression[down-expression] of MALAT1 significantly inhibited BC cell proliferation and migration by targeting microRNA (miR)‑34a. The expression levels of miR‑34a were significantly decreased in BC tissues and cell lines compared with that of adjacent non‑tumour tissues and SV‑HUC‑1 cells. In addition, the expression of miR‑34a was inversely correlated with the expression of MALAT1 in BC tissues. The present study revealed that cyclin D1 (CCND1) was identified as a target gene of miR‑34a, and its expression was negatively mediated by miR‑34a in BC cells. Furthermore, the expression levels of MALAT1 were significantly increased in the BC tissues at stage III-IV compared with that in the tissues at stage I-II (Fig. 1B). These patients with BC were subsequently divided into high- and low-MALAT1 expression groExpression[Expression[up-expression]-expression]s based on the mean expression value in the BC tissues. As indicated in Table I, high expression of MALAT1 was significantly associated with advanced Tumour, Node, Metastases (TNM) stage and positive lymph node metastasis. Furthermore, patients with high MALAT1 expression exhibited a shorter survival time when compared with those with a low MALAT1 expression (Fig. 1C). Yes Furthermore, knockExpression[down-expression] of MALAT1 significantly inhibited BC cell proliferation and migration by targeting microRNA (miR)‑34a. 30387807 MALAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines (HSC3, SCC9, SCC15 and SCC25) regulation[miR-101/EZH2 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay qPCR analysis indicated that MALAT1 expression was obviously increased, and miR-101 was decreased in the OSCC tissues and cell lines.Collectively, these findings revealed that upregulation of MALAT1 facilitated OSCC proliferation and invasion by targeting the miR-101/EZH2 axis. Yes Functional studies revealed that overexpression of MALAT1 promoted OSCC cell proliferation and invasion. 32934732 MALAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues regulation[miR-143-3p/MAGEA9 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay QRT-PCR results showed that MALAT1 and MAGEA9 were expressed at higher levels and miR-143-3p was expressed at lower levels in OSCC tissues.Taken together, our results suggest that MALAT1 functions as a competing endogenous RNA (ceRNA) in promoting OSCC cell proliferation and migration abilities through the miR-143-3p/MAGEA9 axis, thus providing new therapeutic targets for treatment of OSCC. Yes Dramatic suppression of cell proliferation and migration abilities were caused by MALAT1 knockdown or miR-143-3p overexpression in CAL-27 cells. 32879299 hsa_circ_0073237 CircRNA Homo sapiens Glioma glioma cell lines Interaction(miR-345/HDGF pathway) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Transwell Assay Previous studies found that circRNA-hsa_circ_0073237 was upregulated in gliomas. Our further analyses of the biological function and molecular mechanism of hsa_circ_0073237 showed that hsa_circ_0073237 was also upregulated in glioma cell lines and could combine with miR-345 to inhibit its expression. Therefore, hsa_circ_0073237 can regulate the biological functions of glioma cells through miR-345/HDGF, thereby affecting the progression of tumors, indicating that the hsa_circ_0073237/miR-345/HDGF pathway may be a key target for the treatment of glioma. Yes Hsa_circ_0073237 siRNA, miR-345, and HDGF siRNA effectively inhibited cell viability and invasion and promoted cell apoptosis. When expression of hsa_circ_0073237 and miR-345 was inhibited simultaneously, cell viability, apoptosis, and invasion did not change significantly 34348265 MALAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(MALAT1/miR-224-5p/ KDM2A) CCK8//qRT-PCR//MeRIP METTL14 and lncRNA MALAT1 were upregulated, and miR-224-5p was downregulated in OSCC tissues and cells. Overexpression of MALAT1 and KDM2A or miR-224-5p downregulation reversed the inhibition of silencing METTL14 on OSCC cell proliferation. METTL14 induced m6A modification of MALAT1 to upregulate MALAT1. MALAT1 is comparatively bound to miR-224-5p to promote KDM2A transcription. In vivo, METTL14 promoted tumor growth via regulating MALAT1/miR-224-5p/ KDM2A. Yes Silencing METTL14 repressed OSCC cell viability and colony formation. 35467063 MALAT1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Regulation[PI3K-Akt Signaling Pathway] Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay MALAT1 was significantly up-regulated in osteosarcoma tissues compared with adjacent non-tumor soft tissues. Our data revealed for the first time that MALAT1 increases stem cell-like properties by up-regulating RET via sponging miR-129-5p, and thus activates the PI3K-Akt signaling pathway and provides potential therapeutic targets for osteosarcoma treatment. Yes Overexpression of MALAT1 promoted osteosarcoma cell proliferation, migration, and invasion in vitro and enhanced tumor growth in a tumor xenograft mouse model. 30481748 MALAT1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Regulation[miR‑34a/cyclin D1 axis] qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay The results demonstrated that MALAT1 and CCND1 mRNA expression levels were upregulated and miR‑34a was downregulated in OS tissues and cells. Moreover, MALAT1 functioned as a ceRNA to suppress miR‑34a expression and in turn upregulate CCND1 in OS cells. Rescue experiments further demonstrated that MALAT1 knockdown partially reversed anti‑miR‑34a‑mediated promotion on OS cell viability, migration and invasion; overexpression of CCND1 partially reversed the effects of MALAT1 silencing on OS progression. Furthermore, in vivo experiments also revealed that MALAT1 promoted OS tumor growth via miR‑34a inhibition and upregulating the expression of CCND1. In conclusion, the present study suggested that MALAT1 exerted its oncogenic function in OS by regulating the miR‑34a/CCND1 axis in OS, which may provide novel insight into the diagnosis and therapy for OS. Additionally, MALAT1 expression was correlated with tumor size, clinical stage and distant metastasis in patients with OS. Yes In addition, MALAT1 promoted OS cell viability, invasion and migration, while MALAT1 silencing exhibited opposing effects. 30365098 MALAT1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Interaction[binding to miR-34a/c-5p and miR-449a/b] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay We found that MALAT1 was frequently upregulated in osteosarcoma samples and cell lines and a high level of MALAT1 predicted poor overall survival in osteosarcoma patients. Mechanistic investigations demonstrated that MALAT1, as a competing endogenous RNA (ceRNA), regulated osteosarcoma proliferation and metastasis through competitively binding to miR-34a/c-5p and miR-449a/b. We found that MALAT1 was frequently upregulated in osteosarcoma samples and cell lines and a high level of MALAT1 predicted poor overall survival in osteosarcoma patients. Yes Knockdown of MALAT1 inhibited proliferation, migration, and invasion of osteosarcoma cells. 30793707 MALAT1 LncRNA Homo sapiens Osteosarcoma OS cell Interaction(miR-150-5p/VEGFA signaling ) qRT-PCR//ELISA//Western Blot MALAT1 expression in OS cells was significantly higher than in normal osteoblasts. Mechanistically, silencing MALAT1 downregulated vascular endothelial growth factor A (VEGFA) expression and upregulated miR-150-5p expression in OS cells, and MALAT1-mediated angiogenic induction by VEGFA in OS microenvironment. Moreover, MALAT1 directly targeted miR-150-5p and miR-150-5p directly target VEGFA in OS. Overexpression of miR-150-5p downregulates VEGFA expression in OS. Yes The functional analysis indicated that MALAT1 appears to enhance OS-induced angiogenesis, in vitro and in vivo analyses, endothelial cell proliferation and migration, chick embryo angiogenesis assay, and zebrafish xenograft model. 34692524 MALAT1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-485-3p/AKT3/mTOR signalling) qRT-PCR//Western Blot miR-485-3p was decreased while c-MET, AKT3, and MALAT1 were increased in human OS tissues and cells. In addition, MALAT1 interacted with miR-485-3p and disinhibited c-MET and AKT3/mTOR signalling. Yes Knockdown MALAT1 or overexpression of miR-485-3p restrained OS tumour growth and lung metastasis in vivo. 33358903 MALAT1 LncRNA Homo sapiens Osteosarcoma OS cell lines and tissue specimens Interaction(miR-124-3p/SphK1 signaling pathway ) CCK8//qRT-PCR MALAT1 was overexpressed in OS cell lines and tissue specimens, and knockdown of MALAT1 significantly inhibited cell proliferation and migration and increased cell apoptosis and the percentage of G0/G1 phase. Furthermore, MALAT1 could directly bind to miR-124-3p and inhibit miR-124-3p expression. Moreover, MALAT1 overexpression significantly relieved the inhibition on OS cell proliferation mediated by miR-124-3p overexpression, which involved the derepression of sphingosine kinase 1 (SphK1). Yes MALAT1 was overexpressed in OS cell lines and tissue specimens, and knockdown of MALAT1 significantly inhibited cell proliferation and migration and increased cell apoptosis and the percentage of G0/G1 phase. 34373692 MALAT1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(miR-590-3p) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Transwell Assay The results indicated that MALAT1 was highly expressed in OS tissues and cell lines. In addition, MALAT1 knockdown upregulated the expression of miR-590-3p in OS cells. In conclusion, MALAT1 was demonstrated to suppress cell apoptosis and induce cell proliferation, migration, invasion and EMT by inhibiting miR-590-3p in OS, which indicated that MALAT1 has potential value in the diagnosis and treatment of OS. Yes MALAT1 knockdown promoted apoptosis and suppressed proliferation, migration, invasion and epithelial- mesenchymal transition (EMT) of OS cells. Overexpression of miR-590-3p increased cell apoptosis and hampered cell proliferation, migration, invasion and EMT in OS cells. 36277152 MALAT1 LncRNA Homo sapiens Parkinson Disease serum Expression(highly expressed) qRT-PCR//Genotyping The results showed that PD patients with high serum level of MALAT1 were associated with lower MMSE score and higher serum levels of IL-1β, IL-6, TNF-α and IFN-γ than patients carrying low serum level of MALAT1 (p < .05). Mutant alleles of SNPs in MALAT1, including rs3200401 (C>T) and rs4102217 (G>C), tended to elevate PD susceptibility and facilitate cytokine production, as compared with their wild alleles (p < .05). Yes And LPS-exposed PC12 cells secreted larger amounts of inflammation cytokines in the pcDNA3.1-MALAT1 group than in the Mock group (p < .05). 34291564 MALAT1 LncRNA Homo sapiens Parkinson Disease Parkinson's disease cell model Interaction(miR-135b-5p/GPNMB axis) qRT-PCR//Luciferase Report Assay//Western Blot MALAT1 was increasingly expressed and downregulation of MALAT1 promoted cell proliferation while inhibited apoptosis in MPP+-stimulated cells. Besides, miR-135b-5p was a target of MALAT1 and directly targeted to GPNMB. Further investigation indicated that suppression of MALAT1 regulated cell proliferation and apoptosis by miR-135b-5p/GPNMB axis. Yes MALAT1 was increasingly expressed and downregulation of MALAT1 promoted cell proliferation while inhibited apoptosis in MPP+-stimulated cells. 33726823 MALAT1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML patients and HL-60 cells Interaction( miR-146a/CXCR4 ) qRT-PCR//Western Blot Firstly, MALAT1 and CXCR4 were upregulated while miR-146a was downregulated in AML patients compared with healthy controls. We observed a negative correlation between miR-146a and MALAT1 or CXCR4, but a positive correlation between MALAT1 and CXCR4 in AML patients. Yes Our results showed that MALAT1 regulates migration, proliferation and apoptosis by sponging miR-146a to regulate CXCR4 expression in AML cells, providing novel insights into the role of MALAT1 as a therapeutic target in AML. 33382018 MALAT1 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Regulation[MALAT1/miR-429 axis ] qRT-PCR We observed that MALAT1 was significantly upregulated in human cervical cancer cell lines compared with the ectocervical epithelial cells. In conclusion, we indicated that the MALAT1/miR-429 axis was involved in cervical cancer development. Yes Silencing of MALAT1 obviously reduced cervical cell viability, induced cell apoptosis, and repressed cell invasion capacity. Conversely, overexpression of MALAT1 exhibited an opposite phenomenon. 30515786 hsa_circ_0001367 CircRNA Homo sapiens Glioma Glioma Cells Interaction(miR-545-3p/LUZP1 Axis ) In Vivo Experiment//Western Blot//Transfection//Tunel//qRT-PCR//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay First, qRT-PCR was conducted, which showed that circ_0001367 level was downregulated in glioma tissues and cells. Taken together, the results of this study demonstrate that the circ_0001367/miR-545-3p/LUZP1 axis may be a novel target for glioma therapy. Yes Next, gain-of-function and loss-of-function assays were performed, which indicated that circ_0001367 inhibited the proliferation, migration and invasion of glioma cells. 34869035 MALAT1 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-384/GOLM1 axis] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay MALAT1 was highly expressed in glioma tissues and cells. The MALAT1/miR-384/GOLM1 axis was first proposed in our report, enriching the action mechanism of MALAT1 in glioma. Yes MALAT1 knockdown inhibited autophagy, migration and invasion of glioma cells. 32196610 hsa_circ_0001162 CircRNA Homo sapiens Glioma glioma tissues Interaction(miR-936/ERBB4 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0001162 was an overexpressed circRNA in glioma. These results indicated that circ_0001162 contributed to the glioma progression via regulating the miR-936/ERBB4 axis, which laid a foundation for the pathomechanism and molecular treatment of glioma. Yes Circ_0001162 promoted glioma cell proliferation, colony formation, migration and invasion in vitro. Tumorigenesis of glioma in vivo was also enhanced by circ_0001162. 34057019 MALAT1 LncRNA Homo sapiens Ovarian Neoplasms cell line Interaction[targeting miR-503-5p] RNA Pull-Down//qRT-PCR//MTT//Luciferase Report Assay//EdU Staining MALAT1 expression in OC cells was elevated compared with HOSE cells. The expression of lncRNA-MALAT1 was negatively associated with the expression of miR-503-5p in OC cells, while luciferase assay and RNA pull-down together supported the direct binding of MALAT1 with miR-503-5p. Knockdown of MALAT1 was able to inhibit the activation of JAK2/STAT3 signal pathway, and MALAT1 overexpression was accompanied by activation of these factors. Yes MTT assay and EdU assay supported that si-MALAT1 could inhibit cell proliferation in OC cells.Treatment of si-MALAT1 results in increased cell apoptosis rate in both SKOV3 cells and OVCAR3 cells. 31496733 MALAT1 LncRNA Homo sapiens Ovarian Neoplasms cell lines (HEY, OVCA420, OVARY1847, OVCA433, CAOV3, and SKOV3) Interaction[RBFOX2] qRT-PCR//Microarray SExpression[up-expression]pression of MALAT1 also resulted in decreased expression of RBFOX2, and alternative processing of the pro-apoptotic tumor sExpression[up-expression]pressor gene KIF1B. RBFOX2 sExpression[up-expression]pression resulted in preferential splicing of the pro-apoptotic isoform of KIF1B (KIFB1B-beta) and increased anoikis. The lncRNA MALAT1 facilitates a pro-metastatic phenotype in ovarian cancer by promoting alternative RNA processing and differential expression of anti-apoptosis and epithelial to mesenchymal transition (EMT)-related genes. Yes MALAT1 knockdown resulted in decreased proliferation, invasion, anchorage-independent growth, and increased anoikis. 30294913 MALAT1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC clinical samples and cell lines Interaction(miR-429) Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Data found that MALAT1 was overexpressed in RCC clinical samples and cell lines. RT-PCR showed that miR-429 expression was downregulated in RCC cell lines, which was negatively correlated with that of MALAT1. Bioinformatics analysis suggested that miR-429 had complementary binding sequences with MALAT1, which was confirmed by dual-luciferase reporter assay. Yes Moreover, loss-of-functional experiments showed that MALAT1 knockdown suppress the proliferation, migration, and invasion abilities of RCC cells. 29588438 circCHAF1A CircRNA Homo sapiens Glioma GSCs Interaction(miR-211-5p/HOXC8 feedback loop) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Bioinformatics Analysis//Transfection//Colony Formation Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//IHC//EdU Staining//IF CircCHAF1A was overexpressed in glioma and related to the low survival rate. Mechanistically, circCHAF1A upregulated transcription factor HOXC8 expression in GSCs through miR-211-5p sponging. Then, HOXC8 can transcriptionally upregulate MDM2 expression and inhibited the antitumor effect of p53. CircCHAF1A was overexpressed in glioma and related to the low survival rate. Yes Functionally, it was found that no matter in vitro or in vivo, circCHAF1A can facilitate the proliferation and tumorigenesis of TP53wt GSCs. 34017077 MALAT1 LncRNA Homo sapiens Colonic Neoplasms CC tissues regulation[miR-101-3p/STC1 Axis] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay The expression of MALAT1 was elevated in CC tissues compared with adjacent normal tissues and was associated with lymph node metastasis, depth of invasion and tumor-node-metastasis (TNM) stage. MALAT1 may function as an oncogene in CC progression by affecting the miR-101-3p/STC1 axis, providing a hopeful therapeutic option for CC. The expression of MALAT1 was elevated in CC tissues compared with adjacent normal tissues and was associated with lymph node metastasis, depth of invasion and tumor-node-metastasis (TNM) stage. Yes Up-regulation of MALAT1 promoted the proliferation, migration, and invasion and inhibited the apoptosis of CC cells; while MALAT1 knockdown exhibited opposite results. 32431516 MALAT1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues regulation[Wnt/β-catenin signaling pathway] Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry MALAT1 expression was significantly higher in colon cancer vs. para-carcinoma tissues.Inhibition of MALAT1 expression in colon cancer may promote apoptosis and hinder cell proliferation by suppressing the activation of Wnt/β-catenin signaling pathway. Yes Knockdown of MALAT1 by siRNA increased the number of apoptotic cells and the apoptosis rate at 24 h post-transfection in SW480 cells. 31733641 MALAT1 LncRNA Homo sapiens Colonic Neoplasms human colon cancer cell lines Interaction(miR-129-5p/HMGB1 axis) colony Formation Assay//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay In our study, it was demonstrated that MALAT1 was upregulated in human colon cancer cell lines including Lovo, HCT116, SW480, and HT29 cells compared to the normal human intestinal epithelial HIEC cells. Moreover, we observed that miR-129-5p was downregulated in colon cancer cells with a significant increase of HMGB1 expression. Inhibition of MALAT1 can inhibit the proliferation of colon cancer SW480 and HCT116 cells and next, bioinformatics analysis was used to predict the target microRNA of MALAT1. Taken together, our results indicated that MALAT1/miR-129-5p/HMGB1 axis could be provided as an important prognostic biomarker in colon cancer development. Yes Inhibition of MALAT1 can inhibit the proliferation of colon cancer SW480 and HCT116 cells and next, bioinformatics analysis was used to predict the target microRNA of MALAT1. 29226325 MALAT1 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial clinical carcinoma tissues Expression [highly expressed] qRT-PCR//Wound Healing Assay Herein, we observed the consistent upregulation of MALAT1 in MYST4-overexpressing cell lines, while MALAT1 was frequently found to be upregulated in various types of clinical carcinoma tissues, especially EOC. Yes We found that MALAT1 overexpression in EOC cell lines significantly increased drug resistance, cell migration, and invasion. Furthermore, the concomitant overexpression of MALAT1 in EOC cells and CAFs dramatically increased EOC cell invasion. Accordingly, a mechanistic investigation of MALAT1 overexpression in EOC cells showed that expressions of the cytokines interleukin (IL)-1β and p-P38/p-NFκB/Cox2/prostaglandin E2 (PGE2) signaling were significantly increased, which stimulated inflammatory responses, whereas cell apoptosis was inhibited due to increased Bcl-2 levels and reduced Caspase3 levels. 34638541 MALAT1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines Interaction[PI3K/Akt pathway] Western Blot//CCK8//RIP//EdU Staining//ChIP MALAT1 was highly expressed and the expression of miR‑22‑3p was suppressed in RCC tissues and cell lines. In conclusion, lncR‑MALAT1 affected the proliferation and migration of RCC cells by targeting miR‑22‑3p through the inactivation of the PI3K/Akt signaling pathway. Yes ShRNA‑mediated knockdown of MALAT1 significantly inhibited the viability and mobility of RCC cells in vitro and in vivo. 30431104 MALAT1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines Interaction[BIRC5] qRT-PCR The expression levels of BIRC5 and MALAT1 were higher in RCC tissues and cell lines than in adjacent normal tissues and a normal renal cortex proximal tubule epithelial cell line. Our study demonstrated that MALAT1 functions as a miR-203 decoy to increase BIRC5 expression in RCC. Yes BIRC5 and MALAT1 promoted cell proliferation yet decreased the percentage of RCC cells at G0/G1 phase. 31250518 MALAT1 LncRNA Homo sapiens Carcinoma, Renal Cell 786‑O‑EVs on RCC cells Regulation Western Blot//qRT-PCR//MTT//Colony Formation Assay//Invasion Assay MALAT1 knockdown attenuated the promotive effect of sole 786‑O‑EVs on RCC cells. MALAT1 located ETS1 in the TFCP2L1 promoter and negatively regulated TFCP2L1, and ETS1 protein could specifically bind to MALAT1. Yes MALAT1 knockdown attenuated the promotive effect of sole 786?O?EVs on RCC cells. 34278501 MALAT1 LncRNA Homo sapiens Osteoarthritis cartilage tissues Regulation[MALAT1/miR-145 axis ] Flow Cytometry//qRT-PCR MALAT1 was upregulated, and miR-145 was downregulated in OA samples and IL-1β-induced chondrocytes. An MALAT1/miR-145 axis contributes to ECM degradation in IL-1β-induced chondrocytes through targeting ADAMTS5, suggesting that MALAT1/miR-145/ADAMTS5 signaling may underlie human OA pathogenesis. Yes Functionally, overexpression of MALAT1 inhibited chondrocyte viability and promoted cartilage ECM degradation in IL-1β-induced chondrocytes. 31637891 MALAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression(highly expressed) qRT-PCR The expression of MALAT1 was markedly upregulated in HCC tissues compared with PANTs. High MALAT1 expression was associated with mutations in two genes leading to poor prognosis and may upregulate some prognostic risk genes through methylation. Yes MALAT1 was significantly co-expressed with various signatures of genes involved in HCC progression, including the cell cycle, DNA damage repair, mismatch repair, homologous recombination, molecular cancer m6A, exosome, ferroptosis, infiltration of lymphocyte (p < 0.05). 36685103 MALAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Interaction[sponging miR-140] qRT-PCR We revealed that the expression of MALAT1 and VEGF-A was significantly increased in HCC cells.Mechanistically, the interaction between MALAT1 and miR-140 or between miR-140 and VEGF-A was confirmed by multiple assays. Besides, a negative correlation between MALAT1 and miR-140 was found in HCC tissues. Furthermore, miR-140 inhibition significantly increased VEGF-A expression, promoted angiogenesis of HUVECs, and redirected the polarization of macrophages toward the M2 subset. In addition, in vivo studies also verified the regulatory network of the MALAT1/miR-140 axis on VEGF-A in HCC progression. In summary, this study revealed the mechanism that MALAT1 worked as a putative HCC promotor via inhibiting miR-140. Therefore, targeting MALAT1 or miR-140 might alleviate the progression of HCC in the future. Yes Knockdown of MALAT1 in HCC cells suppressed the production of VEGF-A, impaired the angiogenesis of HUVECs, and facilitated the polarization of macrophage toward the M1 subset. 31693399 MALAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[MALAT1/miR-124-3p/Slug axis] Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//IHC//Transwell Assay MALAT1 expression was upregulated in HCC tissues and positively correlated with Slug expression.MALAT1 and miR-124-3p bind directly and reversibly to each other. MALAT1 silencing inhibited cell migration and invasion. miR-124-3p inhibited HCC metastasis by targeting Slug. Yes MALAT1 silencing inhibited cell migration and invasion. 31466138 MALAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[BRG1 ] RNA Pull-Down//Western Blot//qPCR//CCK8//RIP//Cell Cycle Assay//ELISA//IHC Here, we found that lncRNA metastasis associated lung adenocarcinoma transcript1 (MALAT1) was upregulated in HCC tumor tissues. Mechanistically, MALAT1 recruited Brahma-related gene 1 (BRG1), a catalytic subunit of chromatin remodeling complex switching/sucrose non-fermentable (SWI/SNF), to the promoter region of IL-6 and CXCL8, and thus facilitated NF-κB to induce the expression of these inflammatory factors. Yes Here, we found that lncRNA metastasis associated lung adenocarcinoma transcript1 (MALAT1) was upregulated in HCC tumor tissues, and knockdown of MALAT1 suppressed proliferation, cell cycle and invasion of HCC cells in response to lipopolysaccharide (LPS) stimulation.Importantly, in vivo silencing of MALAT1 in HCC tissues inhibited growth of HCC xenografts, and also suppressed the expression of pro-inflammatory factors in HCC tissues accordingly. 30546959 MALAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[ sponging miR-125a-3p] qRT-PCR//Luciferase Report Assay//Western Blot HCC tissues exhibited MALAT1 upregulation.These results indicate that MALAT1 modulates FOXM1 expression via being a miR-125a-3p sponge, thus promoting HCC progression. Yes MALAT1 knockdown disrupted proliferation and invasion, whereas miR-125a-3p knockdown partially reversed this phenotype. 31777593 circPOSTN LncRNA Homo sapiens Glioma glioma tissues and cells Interaction( miR-185-5p/KIF1B) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay CircPOSTN was highly expressed in glioma tissues and cells. Mechanistically, circPOSTN acted as miR-185-5p sponge to up-regulate the expression of its target KIF1B. Moreover, miR-185-5p inhibition reversed the anticancer effects of circPOSTN knockdown on glioma tumorigenesis, and miR-185-5p re-expression suppressed the malignant phenotype of glioma cells via targeting KIF1B. Yes Knockdown of circPOSTN restrained glioma cell proliferation, migration and invasion in vitro, as well as hindered glioma xenograft growth in vivo. 34974134 hsa_circ_0002109 CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-129-5P/EMP2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Invasion Assay//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//IHC//EdU Staining In this study, we found that circRNA-0002109 was highly expressed in glioma tissues and cell lines. Investigations into the relevant mechanisms showed that circRNA-0002109 upregulated the expression of EMP2 through endogenous competitive binding of microRNA-129-5P (miR-129-5P), which partially alleviated the inhibitory effect of miR-129-5P on epithelial membrane protein-2 (EMP2) and ultimately promoted the malignant development of glioma. Yes Downregulation of circRNA-0002109 expression inhibited the proliferation, migration, and invasion of glioma cells and inhibited the malignant progression of tumors in vivo. 34938603 MALAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[microRNA-146a/PI3K/Akt/mTOR axis] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot MALAT1 expression was higher in HCC tissues than in normal tissues. Moreover, effects of MALAT1 downregulation on HCC cells were abolished by miR-146a inhibition. miR-146a directly targeted the 3'-untranslated region of PI3K, and PI3K protein level was clearly decreased upon miR-146a mimic transfection. Yes MALAT1 upregulation promoted HCC cell proliferation, whereas MALAT1 downregulation promoted HCC apoptosis and autophagy. 32435156 MALAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular doxorubicin-resistant HCC tissues and cells Interaction(miR-3129-5p/Nova1 axis) In Vivo Experiment//Western Blot//qRT-PCR//migration assay//Cell Viability Assay//Luciferase Report Assay//Invasion Assay MALAT1 and Nova1 were upregulated, while miR-3129-5p expression was decreased in doxorubicin-resistant HCC tissues and cells. Elevation of LncRNA MALAT1 mediated doxorubicin resistance and the progression of HCC via a MALAT1/miR-3129-5p/Nova1 axis. Yes Knockdown of MALAT1 regulated doxorubicin resistance of HCC cells through inhibiting cell proliferation, migration, invasion and promoting apoptosis, but antisense miR-3129-5p released the functional effect of MALAT1 knockdown. Xenograft tumor model suggested that dysregulation of MALAT1 regulated tumor growth and Nova1 to mediate doxorubicin resistance of HCC cells by as a sponge for miR-3129-5p in vivo. 34058824 circNFIX CircRNA Homo sapiens Glioma glioma tissues and cells Regulation[miR-378e/RPN2 axis ] RNA Pull-Down//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The expression of circNFIX was enhanced in glioma tissues and cells compared with matched controls and high expression of circNFIX indicated poor outcomes of patients. Knockdown of circNFIX inhibits progression of glioma in vitro and in vivo by increasing miR-378e and decreasing RPN2, providing a novel mechanism for understanding the pathogenesis of glioma. Yes Knockdown of circNFIX led to arrest of cell cycle, inhibition of glycolysis, migration and invasion and promotion of apoptosis in glioma cells. 31888753 MALAT1 LncRNA Homo sapiens Diabetic Retinopathy cell lines Regulation[miR-125b/VE-cadherin axis ] Western Blot//qRT-PCR//MTT//ELISA//Transwell Assay MALAT1 and VE-cadherin were up-regulated while miR-125b was down-regulated in hRMECs treated with HG. Knockdown of MALAT1 inhibited cell proliferation, migration and angiogenesis of hRMECs via suppressing the VE-cadherin/β-catenin complex through targeting miR-125b. Inhibition of MALAT1 may serve as a potential target for anti-angiogenic therapy for DR. Yes Knockdown of MALAT1 inhibited the proliferation, migration, tube formation and vascular permeability of hRMECs induced by HG through up-regulating miR-125b. 30988072 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue Regulation(MALAT1-FOXP3-GINS1 axis) RNA Pull-Down//Western Blot//Co-IP//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//IF In this study, the clinicopathologic significance of MALAT1 and GINS1 in NSCLC was investigated, a positive correlation in their expression was found. The silencing of MALAT1 decreased GINS1 expression and inhibited NSCLC proliferation in vitro and in vivo. The upregulation of GINS1 reversed NSCLC proliferation inhibited by MALAT1 knockdown. FOXP3 (forkhead box protein 3) was identified as the critical transcription factor for GINS1 transcription. In addition, MALAT1 could stabilize FOXP3 by binding to zinc finger (ZF) domain and leucine zipper (LZ) domain of FOXP3. Interestingly, these two domains were also interaction domains for FOXP3 binding with E3 ligase STUB1 (STIP1 homology and U-box containing protein 1). In this way, MALAT1 masked the protein-interacting domain, and inhibited FOXP3 ubiquitination by STUB1. Yes The silencing of MALAT1 decreased GINS1 expression and inhibited NSCLC proliferation in vitro and in vivo. The upregulation of GINS1 reversed NSCLC proliferation inhibited by MALAT1 knockdown. FOXP3 (forkhead box protein 3) was identified as the critical transcription factor for GINS1 transcription. 33972684 LY6E-DT LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Expression[highly expressed] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//IP//Colony Formation Assay LOC100133669 was upregulated in ESCC tissues compared with adjacent non-tumour tissues. High LOC100133669 expression was associated with poor prognosis of patients with ESCC. Yes Knockdown of LOC100133669 inhibited ESCC cell proliferation and cell cycle progression, while overexpression of LOC100133669 showed the opposite effects. 32130753 LURAP1L-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction(LURAP1L/IKK/IκB/NF-κB signaling pathway) qRT-PCR//IF Therefore, LURAP1L-AS1 was selected and PDGF-BB was demonstrated to upregulate the expression of LURAP1L-AS1 and LURAP1L, which was reversed by a PDGFR-β inhibitor. The present study indicates that LURAP1L-AS1/LURAP1L/IKK/IĸB/NF-κB plays an important regulatory role in PDGF-BB-induced fibroblast activation and may become a potential target for the treatment of OSCC. Yes Subsequently, knocking down LURAP1L-AS1 suppressed the expression of PDGF-BB-induced fibroblast activation marker protein α-smooth muscle actin, fibroblast activation protein-α, PDGFR-β and phosphorylated (p)-PDGFR-β. IKKα, p-IĸB and p-NF-κB were downregulated by the knockdown of LURAP1L-AS1 and upregulated by overexpression of LURAP1L-AS1. 34079593 LUNAR1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[suppress IGF1] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Significantly increased expression of LUNAR1 in clinical CRC specimens was detected compared with that in matching normal tissues.Moreover, the inhibition of LUNAR1 can significantly suppress IGF1 signalling in CRC. LUNAR1 expression in CRC was found to be associated with the tumour aggressiveness, disease-free survival and overall survival of patients. Yes The downregulation of LUNAR1 in SW620 cells inhibited cell proliferation, migration, invasion and tumour growth while inducing apoptosis. 31882986 LUNAR1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[miR-495-3p/MYCBP axis] Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay RT?qPCR and Pearson's correlation analysis revealed that LUNAR1 was highly expressed and was negatively associated with the overall survival of CRC patients.In conclusion, LUNAR1 accelerates CRC progression via the miR‑495‑3p/MYCBP axis, indicating that LUNAR1 may serve as a prognostic biomarker for CRC patients. RT?qPCR and Pearson's correlation analysis revealed that LUNAR1 was highly expressed and was negatively associated with the overall survival of CRC patients. Yes Moreover, CCK?8, clone formation, wound?healing migration, Transwell chamber and FACs assay analyses showed that LUNAR1 knockdown inhibited CRC cell proliferation, migration and invasion, while accelerating cell apoptosis. 33300052 LUCRC LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//Wound Healing Assay//RNA-seq//Transwell Assay It was found that LUCRC was nearly undetectable in six out of seven healthy control donors, but it was expressed in a significantly higher level in all seven colorectal cancer patients (Figure 5). Yes We then tested whether these lncRNAs affect colorectal cancer cell proliferation by using HCT116 as a model cell line. HCT116 cells were transfected with control siRNA (siCTL) or siRNA specifically targeting each individual lncRNA, followed by cell proliferation assay. Out of the 10 lncRNAs being tested, knockExpression[down-expression] of several of them resulted in growth defects of HCT116 cells and lncRNA LOC105371049 seemed to affect HCT116 cell growth the most (Figure 2F). The knockExpression[down-expression] efficiency of siRNAs targeting the 10 lncRNAs was examined by RT-qPCR analysis (Figure S2F). We named lncRNA LOC105371049 as LUCRC (LncRNA Expression[Expression[up-expression]-expression]regulated in Colorectal Cancer). 32082365 circERBB2 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Interaction(miR-136-5p) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis//Transwell Assay We observed that circ-ERBB2 was overexpressed in TNBC, and TNBC patients with high circ-ERBB2 expression levels had a poor prognosis. We observed that circ-ERBB2 was overexpressed in TNBC, and TNBC patients with high circ-ERBB2 expression levels had a poor prognosis. Yes Functionally, circ-ERBB2 knockdown constrained TNBC growth in vivo, reduced the Warburg effect, accelerated apoptosis, and repressed the proliferation, migration, and invasion of TNBC cells in vitro. Mechanically, circ-ERBB2 sponged microRNA 136-5p (miR-136-5p) to elevate pyruvate dehydrogenase kinase 4 (PDK4) expression. 34370552 LUCAT1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and paracancer tissues Regulation[miR-134-5p/YWHAZ axis ] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay the expression of lncRNA LUCAT1 in gastric cancer tissue was significant higher than that in adjacent tissues. LncRNA LUCAT1 could promote proliferation and invasion of gastric cancer by regulating miR-134-5p/YWHAZ axis. Patients with high LUCAT1 level displayed short overall survival and disease-free survival periods. Yes LUCAT1 knockdown or miR-134-5p overexpression decreased the proliferation, colony formation, migration and invasion of SGC7901 cells. 31545227 LUCAT1 LncRNA Homo sapiens Stomach Neoplasms GC cell lines and tissues regulation[CXXC4 and SFRP2 ] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Colony Formation Assay LUCAT1 expression in GC cell lines and tissues was significantly elevated, compared to that in normal gastric cells and adjacent non-tumor tissues (p<0.001). We concluded that LUCAT1 induces methylation of CXXC4 and SFRP2, thereby regulating Wnt/β-catenin signaling in GC. Yes Two different siRNAs for LUCAT1 reduced cell proliferation, invasion, and migration, compared to siCT (p<0.05), and these reductions were restored by pcDNA-LUCAT1 (p<0.05). 33107235 LUCAT1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues ,cell lines Interaction[lnc-LUCAT1/miR-7-5p-SOX2] Western Blot//CCK8//qRT-PCR//EdU Staining//Transwell Assay Our results indicated that the expression of lnc-LUCAT1 was highly up-regulated in breast cancer tissues and cell lines.Moreover, lnc-LUCAT1 was found to be a target of miR-7-5p. There was a negative correlation between lnc-LUCAT1 and miR-7-5p. The reduction of miR-7-5p was required in the augmentation of breast cancer development induced by lnc-LUCAT1 over-expression. In addition, SOX2 acted as a target of miR-7-5p. SOX2 was an oncogene in breast cancer through promoting cell proliferation, migration and invasion. The in vivo study confirmed the role of lnc-LUCAT1 in promoting tumor growth, accompanied with down-regulated SOX2 expression, whereas up-regulated miR-7-5p. Yes Over-expression of lnc-LUCAT1 enhanced cell proliferation, migration and invasion in breast cancer cell lines. 31635802 circGNB1 CircRNA Homo sapiens Triple Negative Breast Neoplasms cell lines regulation[ miR-141-5p-IGF1R Axis] Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Microarray Validating by qRT-PCR, circGNB1 was overexpressed in TNBC cell lines and high expression of circGNB1 was associated with worse clinical features and survival outcomes. Altogether, our study demonstrated the pivotal role of circGNB1-miR-141-5p-IGF1R axis in TNBC growth and metastasis though the mechanism of competing endogenous RNAs. Validating by qRT-PCR, circGNB1 was overexpressed in TNBC cell lines and high expression of circGNB1 was associated with worse clinical features and survival outcomes. The expression of circGNB1 was positively correlated with tumor size and clinical stage, and high expression of circGNB1 was an independent risk factor for TNBC patients. Yes Both in vitro and in vivo assays revealed that knockdown of circGNB1 significantly suppressed cell proliferation, migration and tumor growth. 32194644 LUCAT1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines regulation[LUCAT1/miR-181a-5p axis] qRT-PCR//Luciferase Report Assay qRT-PCR analysis indicated that, compared with the adjacent tissues and MCF-10A normal breast epithelial cells, LUCAT1 was markedly up-regulated in the breast cancer tissues and five BC cell lines, including MDA-MB-231, MDA-MB-468, MDA-MB-435, SKBR3, and MCF-7. Our data indicate that LUCAT1/miR-181a-5p axis can serve as a novel therapeutic target in breast cancer. Yes The knockdown of LUCAT1, through the transfection of small interfering RNA (siRNA) specific to LUCAT1, resulted in inhibition of proliferation in breast cancer cells. 32998707 LUCAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[RPL40-MDM2-p53 pathway] qRT-PCR//Microarray Among them, we found that the lncRNA lung cancer-associated transcript 1 (LUCAT1) was upregulated in CRC tissues and was closely associated with poor overall survival of CRC patients, through analysis of clinical data and The Cancer Genome Atlas. Mechanistically, bioinformatic analysis indicated that low expression of LUCAT1 was associated with the p53 signaling pathway. Chromatin isolation by RNA purification followed by mass spectrometry and RNA immunoprecipitation revealed that LUCAT1 bound with UBA52, which encodes ubiquitin and 60S ribosomal protein L40 (RPL40). We found that RPL40 functions in the ribosomal protein-MDM2-p53 pathway to regulate p53 expression. Taken together, our findings indicate that suppression of LUCAT1 induces CRC cell cycle arrest and apoptosis by binding UBA52 and activating the RPL40-MDM2-p53 pathway. These results implicate LUCAT1 as a potential prognostic biomarker and therapeutic target for CRC. Among them, we found that the lncRNA lung cancer-associated transcript 1 (LUCAT1) was upregulated in CRC tissues and was closely associated with poor overall survival of CRC patients, through analysis of clinical data and The Cancer Genome Atlas. Yes Functional studies indicated that LUCAT1 promoted CRC cell proliferation, apoptosis, migration, and invasion in vitro and in vivo. Furthermore, knockdown of LUCAT1 rendered CRC cells hypersensitive to oxaliplatin treatment. 30690837 LUCAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[ regulate MYC expression] qRT-PCR LUCAT1 is identified as a putative oncogene, which is significantly upregulated in CRC and is associated with poor prognosis. Our results suggest that LUCAT1 plays a critical role in CRC cell proliferation by inhibiting the function of NCL via its G-quadruplex structure and may serve as a new prognostic biomarker and effective therapeutic target for CRC. Yes Loss of LUCAT1 restricts CRC proliferative capacities in vitro and in vivo. 33097685 LUCAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(MiR-133b) RIP//Luciferase Report Assay//Transwell Assay MiR-133b was expressed at low levels in CRC tissues, and LUCAT1 was highly expressed, with an inverse correlation between them. However, the dual luciferase assay showed that miR-133b did not directly target LUCAT1. Yes LUCAT1 promoted the migration and invasion of HCT116 and SW620 cells. Overexpression of LUCAT1 attenuated the inhibition of cell migration and invasion induced by miR-133b. 33541136 LUCAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[ inhibiting ANXA2 ] RNA Pull-Down//Northern Blot//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//FISH//Invasion Assay Our results demonstrated that LUCAT1 was up-regulated in HCC tissues and cells. Furthermore, RNA pulldown and Western blot assays indicated that LUCAT1 inhibited the phosphorylation of Annexin A2 (ANXA2) to reduce the degradation of ANXA2-S100A10 heterotetramer (AIIt), which in turn accelerated the secretion of plasminogen into plasmin, thereby resulting in the activation of metalloprotease proteins. Yes Loss- and gain-of-function studies revealed that LUCAT1 promotes the proliferation and metastasis of HCC cells in vitro and in vivo. 30588744 LUCAT1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer cell lines interaction[miR-199a-5p] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay LncRNA LUCAT1 was highly expressed in three human ovarian cancer cell lines compared to that in normal ovarian surface epithelial cell line (p<0.05).LncRNA LUCAT1 is overexpressed in ovarian cancer cells, which may target miR-199a-5p to exert its effects on driving the malignant development of ovarian cancer. Yes The cell proliferation rate in SK-OV-3 cells with lncRNA LUCAT1 knockdown was remarkably lower in comparison to that in control group. 32141534 LUCAT1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder carcinoma tissue and cells regulation[Targeting miR-181c-5p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The results demonstrated that LUCAT1 was overexpressed in bladder cancer tissue and cells, while miR-181c-5p showed a low expression pattern as compared to normal bladder cells and tissues. Collectively, this study reveals that knockdown of LUCAT1 inhibits the migration and invasion of bladder cancer cells in a miR-181c-5p-dependent manner, which may be related to KRAS downregulation. Yes Cell proliferation, migration, and invasion capacities were significantly impaired, and cell apoptosis was enhanced when LUCAT1 was silenced in UM-UC-3 and T24 cell lines, but this effect was abolished by miR-181c-5p downregulation. 33282949 LUCAT1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma tissues Interaction[sponging miR-539] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay The qRT-PCR analysis and in situ hybridization staining showed that lncRNA LUCAT1 expression was significantly increased in tumorous tissues compared with adjacent normal tissues.Mechanistic studies uncovered that lncRNA LUCAT1 acted as a molecular sponge of miR-539 and that miR-539 mediated the effects of lncRNA LUCAT1 on PDAC cell proliferation, cell cycle progression, and motility. Collectively, our findings may offer some novel insights into understanding lncRNA LUCAT1 in PDAC. Yes unctional studies demonstrated that lncRNA LUCAT1 knockdown dramatically sExpression[up-expression]pressed PDAC cell proliferation, induced cell cycle arrest and inhibited cell migration and invasion. Tumor xenograft in vivo assays displayed that lncRNA LUCAT1 inhibited tumorigenecity of PDAC cells. 31789465 LUCAT1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Interaction[sponging miR-181a] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay//ChIP In this study, we, first, confirmed that LUCAT1 acted as an up-regulated lncRNA by analyzing the data from GCTA dataset and RT-PCR in both CC tissues and cell lines. Mechanistically, Bioinformatic tools predicted that miR-181a may target LUCAT1, which was confirmed using luciferase reporter assay and RNA immunoprecipitation (RIP) assays. Overall, our findings showed that SP1-activated LUCAT1 exerts an oncogenic function in CC by binding to miR-181a, suggesting that miR-181a may be a ponderable and promising therapeutic target for CC. Then, clinical assays showed that LUCAT1 was associated with advanced clinical progression and poor prognosis of CC patients.Importantly, multivariate Cox model confirmed that LUCAT1 expression was an independent prognostic factor for both 5-year overall survival in CC. Yes Then, lost-function assays revealed that knockdown of LUCAT1 significantly suppressed CC cells proliferation, colony formation, migration, invasion and EMT by a series of cells experiments. 30831032 LUCAT1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues, cell lines Interaction[modulating miR-5702] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay In our study, we identified that LUCAT1 expression was dramatically enhanced in TNBC samples and cells. High LUCAT1 expression was strongly associated with advanced stages and poor prognosis of TNBC. Yes Moreover, miR-5702 was proved to directly bind to LUCAT1 and be negatively modulated by LUCAT1. Knockdown of miR-5702 reversed the suppressing influences of LUCAT1 depletion on TNBC progression. In conclusion, it was the first investigation to shed light on the significant function and underlying regulatory mechanism of LUCAT1 in TNBC tumorigenesis. 31399501 LVBU LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Regulation(BCL6-p53 signaling axis) RNA Pull-Down//ChIP Here, we characterized a hypoxia-induced lncRNA LVBU (lncRNA regulation via BCL6/urea cycle) that is highly expressed in colorectal cancer (CRC) and correlates with poor cancer prognosis. Mechanistically, overexpression of LVBU competitively bound miR-10a/miR-34c to protect BCL6 from miR-10a/34c-mediated degradation, which in turn allows BCL6 to block p53-mediated suppression of genes (arginase1 ARG1, ornithine transcarbamylase OTC, ornithine decarboxylase 1 ODC1) involved in UC/polyamine synthesis. Taken together, elevated LVBU can regulate BCL6-p53 signaling axis for systemic UC/polyamine synthesis reprogramming and confers a predilection toward CRC development. Here, we characterized a hypoxia-induced lncRNA LVBU (lncRNA regulation via BCL6/urea cycle) that is highly expressed in colorectal cancer (CRC) and correlates with poor cancer prognosis. Yes Increased LVBU expression promoted CRC cells proliferation, foci formation and tumorigenesis. Further, LVBU regulates urea cycle and polyamine synthesis through BCL6, a negative regulator of p53. 35906392 hsa_circ_102229 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Interaction(miR-152-3p/PFTK1 pathway) In Vivo Experiment//Western Blot//ISH//Transfection//EdU Staining//Tunel//CCK8//qRT-PCR//Flow Cytometry//IF//FISH//Luciferase Report Assay//Microarray//IHC//Bioinformatics Analysis//Transwell Assay In TNBC tissues and cells, hsa_circ_102229 was remarkably up-regulated. Furthermore, hsa_circ_102229 directly targeted miR-152-3p and could regulate the expression of PFTK1 by targeting miR-152-3p. Patients with TNBC presenting high hsa_circ_102229 exhibited poor prognosis. Yes Moreover, hsa_circ_102229 could promote the migration, proliferation and invasion, whereas it inhibited the apoptosis of TNBC cells. 34031947 MAGI2-AS3 LncRNA Homo sapiens cervical squamous cell carcinoma CSCC tissues Interaction[ upregulating CDK6] CCK8//qRT-PCR qRT-PCR results showed that CDK6 and MAGI2-AS3 were both up-regulated in CSCC and positively correlated with each other.In CCK-8 assay, MAGI2-AS3 and CDK6 over-expression led to increased proliferation rate of CSCC cells by reducing CDK6 levels, while MAGI2-AS3 siRNA didn't. High levels of MAGI2-AS3 were associated with the poor survival of CSCC patients. Yes In CCK-8 assay, MAGI2-AS3 and CDK6 over-expression led to increased proliferation rate of CSCC cells by reducing CDK6 levels, while MAGI2-AS3 siRNA didn't. 31832086 circBACH2 CircRNA Homo sapiens Triple Negative Breast Neoplasms The 38 pairs of TNBC cancerous tissues and adjacent normal tissues Interaction(miR-186-5p and miR-548c-3p) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//FISH//Luciferase Report Assay//H&E Staining//Cell Cycle Assay//Colony Formation Assay//Invasion Assay Among them, circBACH2 was most significantly elevated in TNBC cancerous tissues and its high expression was positively correlated to the malignant progression of TNBC patients. Mechanistically, circBACH2 sponged miR-186-5p and miR-548c-3p, thus releasing the C-X-C chemokine receptor type 4 (CXCR4) expression. Among them, circBACH2 was most significantly elevated in TNBC cancerous tissues and its high expression was positively correlated to the malignant progression of TNBC patients. Yes In normal human mammary gland cell line, the overexpression of circBACH2 facilitated epithelial to mesenchymal transition and cell proliferation. In TNBC cell lines, circBACH2 knockdown suppressed the malignant progression of TNBC cells. 33875646 MAGI2-AS3 LncRNA Homo sapiens Liver Neoplasms tumor tissues Interaction(miRNA-23a-3p/PTEN axis) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//IF//MTT//Luciferase Report Assay//Cell Apoptosis Assay//Microarray//Invasion Assay//Transwell Assay The expression of lncRNA MAGI2-AS3 was significantly downregulated in tumor tissues. Through WB assay, MAGI2-AS3 could increase PTEN and depress p-AKT and MMP-9 protein expressions via miRNA-23a-3p suppression. MAGI2-AS3 expression was closely correlation with HCC patient's clinicopathology and prognosis and prognosis. Yes In the cell experiment, compared with the negative control (NC) group, MAGI2-AS3 overexpression reduced cell proliferation, invasion, and migration and increased cell apoptosis in Bel-7402 and Huh-7 cell lines. However, when Bel-7402 and Huh-7 cells were transfected with miRNA-23a-3p, their biological activities (proliferation, invasion, and migration) were significantly increased. 34026068 hsa_circ_0041732 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Interaction(miR-149-5p/FGF5 pathway) In Vivo Experiment//IHC//Western Blot//Transfection//Wound Healing Assay//Tube Formation Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Colony Formation Assay//Invasion Assay//Transwell Assay Circ_0041732 and FGF5 expression were significantly upregulated, whereas miR-149-5p was downregulated in TNBC tissues and cells compared with normal breast tissues and cells, respectively. Additionally, circ_0041732 regulated TNBC cell tumor properties by binding to miR-149-5p. MiR-149-5p also modulated TNBC cell tumor properties by targeting FGF5. Furthermore, circ_0041732 knockdown hindered tumor formation in vivo. Yes Circ_0041732 silencing inhibited TNBC cell proliferation, migration, invasion, and tube formation, but induced apoptosis. 35341378 circWHSC1 CircRNA Homo sapiens Triple Negative Breast Neoplasms BC tissues and cells Interaction(miR-212-5p/AKT3 axis.) qRT-PCR CircWHSC1 was upregulated in BC tissues and cells. Also, circWHSC1 could discriminate BC tissues and paracancerous normal tissues. CircWHSC1 regulated AKT3 expression by sponging miR-212-5p. Silencing of miR-212-5p overturned circWHSC1 knockdown-mediated impacts on malignancy and glycolysis of TNBC cells. AKT3 overexpression reversed the inhibitory effect of miR-212-5p mimic on malignancy and glycolysis of TNBC cells. TNBC patients with high circWHSC1 possessed a poor prognosis. Yes CircWHSC1 silencing reduced TNBC cell growth in vivo and repressed proliferation, migration, invasion, glycolysis, and induced apoptosis of TNBC cells in vitro. 34624276 MAGI1-IT1 LncRNA Homo sapiens Stomach Neoplasms 120 pairs of GC patient tumor, paracancerous tissues, human GES-1 control cells and human AGS, MKN-74, MKN-45, and MGC-803 GC cell lines Interaction(miR-302d-3p/IGF1 Axis) In Vivo Experiment//CCK8//qRT-PCR//RIP//Luciferase Report Assay//ELISA Elevated MAGI1-IT1 expression was detected in GC cell lines and tissues, and was linked to poorer patient overall survival. Knocking down this lncRNA disrupted GC cell proliferation in vitro and in vivo, and miR-302d-3p was identified as a MAGI1-IT1 target. IGF1 was subsequently identified as a miR-302d-3p target gene that was upregulated by MAGI1-IT1 through miR-302d-3p. Elevated MAGI1-IT1 expression was detected in GC cell lines and tissues, and was linked to poorer patient overall survival. Yes Knocking down this lncRNA disrupted GC cell proliferation in vitro and in vivo, and miR-302d-3p was identified as a MAGI1-IT1 target. 33833579 hsa_circ_0000520 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cell lines Interaction( miR-1296/ZFX axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//H&E Staining//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Circ_0000520 expression was upregulated in TNBC tissues and cell lines.miR-1296 was verified as a target of circ_0000520, and circ_0000520 silencing-mediated suppressive effects on the malignant potential of TNBC cells were partly overturned by miR-1296 knockdown. miR-1296 interacted with the 3' untranslated region (3'UTR) of ZFX, and ZFX overexpression partly reversed miR-1296 overexpression-mediated effects in TNBC cells. Yes Circ_0000520 knockdown suppressed the proliferation, migration, and invasion whereas induced the apoptosis of TNBC cells. 34324278 circPDCD11 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Interaction(miR-432-5p/LDHA ) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Transfection//qRT-PCR//Luciferase Report Assay//Microarray//EdU Staining The results revealed that circPDCD11 expression was significantly upregulated in TNBC tissues and cells. Mechanistically, circPDCD11 acted as a miRNA sponge to enhance LDHA expression by sponging miR-432-5p. Clinical data demonstrated that the high expression of circPDCD11 was closely correlated with a poor prognosis and acted as an independent risk factor for TNBC prognosis. Yes Functionally, in vitro gain- and loss-of-function experiments revealed that circPDCD11 accelerated glucose uptake, lactate production, ATP generation, and the extracellular acidification rate in TNBC cells. In vivo, circPDCD11 silencing repressed tumor growth. 34420029 circEIF6 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Regulation In Vivo Experiment//Western Blot//Wound Healing Assay//Invasion Assay//Co-IP//Migration Assay//FISH//circRNA-seq//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay//EdU Staining Mechanistically, we found that circ-EIF6 contains a 675-nucleotide (nt) open reading frame (ORF) and that the -150-bp sequence from ATG functioned as an internal ribosome entry site (IRES), which is required for translation initiation in 5' cap-independent coding RNAs. By intersecting circRNA sequencing data from clinical samples and cell lines, we identified a circRNA, termed circ-EIF6, which predicted a poorer prognosis and correlated with clinicopathological characteristics in a cohort of TNBC patients. Yes Functionally, we showed that circ-EIF6 promoted the proliferation and metastasis of TNBC cells in vitro and in vivo. 34450253 circHIF1A CircRNA Homo sapiens Triple Negative Breast Neoplasms breast cancer tissues Regulation(NFIB/FUS positive feedback loop) In Vivo Experiment In our present study, we found that the novel circRNA circHIF1A was significantly overexpressed in breast cancer tissues and that it was associated with metastasis, poor prognosis, and the TNBC subtype. Mechanistically, circHIF1A modulated the expression and translocation of NFIB through posttranscriptional and posttranslational modifications, resulting in the activation of the AKT/STAT3 signaling pathway and inhibition of P21. In our present study, we found that the novel circRNA circHIF1A was significantly overexpressed in breast cancer tissues and that it was associated with metastasis, poor prognosis, and the TNBC subtype. Yes Overexpression of circHIF1A significantly promoted TNBC growth and metastasis in vitro and in vivo, while knockdown of circHIF1A exerted the opposite effects. 33714984 circCD44 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Interaction( miR-502-5p/KRAS and IGF2BP2/Myc axes) In Vivo Experiment//RNA Pull-Down//Northern Blot//IHC//Western Blot//Flow Cytometry//FISH//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay//EdU Staining CircCD44 is an uncharacterized circRNA, which is highly expressed in TNBC, and its expression is negatively correlated with the prognosis of TNBC patients. CircCD44 promotes TNBC proliferation, migration, invasion and tumorigenesis at least partially by sponging miR-502-5p and interacting with IGF2BP2. CircCD44 is an uncharacterized circRNA, which is highly expressed in TNBC, and its expression is negatively correlated with the prognosis of TNBC patients. Yes CircCD44 promotes TNBC proliferation, migration, invasion and tumorigenesis at least partially by sponging miR-502-5p and interacting with IGF2BP2. 34696797 circPSMA1 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells, exosomes, and serum exosomes samples from TNBC patients. Interaction( miR-637/Akt1/β-catenin (cyclin D1) axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Transwell Assay "We identified increased circRNA circPSMA1 in TNBC cells, their exosomes, and serum exosomes samples from TNBC patients. Mechanistically, circPSMA1 acted as a ""miRNAs sponge"" to absorb miR-637; miR-637 inhibited TNBC cell migration and metastasis by directly targeted Akt1, which recognized as a key immune-related gene and affected downstream genes β-catenin and cyclin D1. " Yes The overexpression of circPSMA1 promoted TNBC cell proliferation, migration, and metastasis both in vitro and in vivo. 33911067 MACC1-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells regulation[SMAD2/MACC1-AS1 axis] Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//ChIP In this work, it was shown that lncRNA MACC1-AS1 was highly expressed in NPC tissues and cells relative to the adjacent tissues and nasal mucosa cells, respectively.Therefore, these results demonstrate a novel MACC1-AS1/miR-145/Smad2 negative loop responsible for NPC cell stemness. Additionally, MACC1-AS1 expression was positively correlated with the high rate of lymph node metastasis and large tumor size. Yes in vitro and in vivo experiments revealed that MACC1-AS1 knockdown reduced the stemness of NPC cells, which was indicated by the decrease of sphere-forming ability, ALDH1 activity, stemness marker expression and tumor-initiating capacity. 32058221 MACC1-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues regulation[Downregulating PTEN] CCK8//qPCR//Western Blot MACC1-AS1 was upregulated in LUAD and inversely correlated with the expression of PTEN. The authors' results demonstrated that MACC1-AS1 promoted cell proliferation by downregulating PTEN in LUAD cells. High expression levels of MACC1-AS1 in LUAD tissues were closely correlated with poor survival rate of LUAD patients. Yes In LUAD cells, overexpression of MACC1-AS1 led to decreased expression of PTEN and increased proliferation rate of LUAD cells, while MACC1-AS1 silencing led to increased expression of PTEN and decreased proliferation rate of LUAD cells. 32109147 MACC1-AS1 LncRNA Homo sapiens Pancreatic Carcinoma PC tissues Regulation[PAX8/NOTCH1 signaling pathway] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP Numbers of differentially expressed lncRNAs in PC were identified via lncRNA microarrays, among which MACC1-AS1 was revealed as the most abundant lncRNA. The upregulation of MACC1-AS1 in PC was further confirmed in two expanded PC cohorts, which showed that MACC1-AS1 expression was upregulated in those PC patients with poor survival.Meanwhile, MACC1-AS1 upregulated the expression of PAX8 protein, which promoted aerobic glycolysis and activated NOTCH1 signaling. Additionally, PAX8 was upregulated in PC tissues, which was correlated with the expression of MACC1-AS1 and the overall survival of PC patients. Yes unctionally, knockdown of MACC1-AS1 inhibited the proliferation as well as metastasis of PC cells. 31391063 MACC1-AS1 LncRNA Homo sapiens cervical squamous cell carcinoma CSCC tissues and cells interaction[microRNA-34a,CDK6] CCK8//qRT-PCR//Cell Cycle Assay//Western Blot It was observed that MACC1-AS1 was upregulated in CSCC, and its expression levels were elevated with the increase in clinical stage.Therefore, the lncRNA MACC1-AS1 may serve as a sponge of miR-34a to upregulate CDK6, thereby promoting cell cycle progression and cell proliferation. It was observed that MACC1-AS1 was upregulated in CSCC, and its expression levels were elevated with the increase in clinical stage. Yes Cell cycle and proliferation analyses demonstrated that MACC1-AS1 and CDK6 promoted cell cycle progression and cell proliferation. 32194733 hsa_circ_0006220 CircRNA Homo sapiens Triple Negative Breast Neoplasms BC tissues and cell lines Interaction(miR-197-5p/CDH19) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Hsa_circ_0006220 was more downregulated in TNBC than other subtypes of BC tissues and cell lines. Further, hsa_circ_0006220 was confirmed to be a sponge of miR-197-5p, and to indirectly regulate CDH19 expression. A rescue assay indicated the biological function of the hsa_circ_0006220/miR-197-5p/CDH19 pathway in TNBC cells. Yes In vitro data showed that hsa_circ_0006220 remarkably inhibited the proliferation, migration, and invasion of TNBC cells. 34532373 LYPLAL1-DT LncRNA Homo sapiens Type 2 Diabetes With Macrovascular Complication EC Interaction(miR-204-5p/SIRT1 axis) Western Blot//Transfection//qRT-PCR//RIP//RNA-seq//Luciferase Report Assay//Transwell Assay Furthermore, these DE-lncRNAs were shown to be significantly related to hypoxia, HG, and IS in EC, especially lncRNA LYPLAL1-DT. LYPLAL1-DT overexpression results in the promotion of the proliferation, and migration of EC, as well as an elevation of autophagy. Overexpressed LYPLAL1-DT reduces the adhesion of monocytes to EC, boosts anti-inflammation, and suppresses inflammatory molecules secreted in the medium.Mechanistically, LYPLAL1-DT acts as competing endogenous RNA (ceRNA) by downregulating miR-204-5p, therefore enhancing SIRT1 and protecting EC autophagy function; thus, alleviating apoptosis. Finally, exosome sequencing revealed LYPLAL1-DT expression was 4 times lower in DMC cells than in healthy samples. Yes Furthermore, these DE-lncRNAs were shown to be significantly related to hypoxia, HG, and IS in EC, especially lncRNA LYPLAL1-DT. LYPLAL1-DT overexpression results in the promotion of the proliferation, and migration of EC, as well as an elevation of autophagy. Overexpressed LYPLAL1-DT reduces the adhesion of monocytes to EC, boosts anti-inflammation, and suppresses inflammatory molecules secreted in the medium. 35508613 LYPLAL1-2 LncRNA Homo sapiens Glioma glioma tumor tissue regulation[miR-217/YWHAG] qRT-PCR//Western Blot//Transwell Assay LncRNA-LYPLAL1-2 was significantly downregulated in glioma tumor tissue.LncRNA-LYPLAL1-2 suppressed glioma metastasis via the miR-217/YWHAG axis and is expected to be a potential target for early diagnosis and treatment of gliomas. Yes LncRNA-LYPLAL1-2 overexpression suppressed migration and invasion in vitro and in vivo. 32913498 circNR3C2 CircRNA Homo sapiens Triple Negative Breast Neoplasms breast cancer tissues/cell lines Interaction(miR-513a-3p/HRD1/Vimentin axis) In Vivo Experiment//RNA Pull-Down//cell invasion assay//Wound Healing Assay//Immunoblotting//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//IF CircNR3C2 (hsa_circ_0071127) is also remarkably downregulated in TNBC, negatively correlated with the distant metastasis and lethality of invasive breast carcinoma. Collectively, we elucidated a bona fide circNR3C2/miR-513a-3p/HRD1/Vimentin axis that negatively regulates the metastasis of TNBC, suggesting that circNR3C2 and HRD1 can act as potential prognostic biomarkers. Yes Overexpressing circNR3C2 in vitro and in vivo leads to a crucial enhancement of the tumor-suppressive effects of HRD1 through sponging miR-513a-3p. 33530981 LY6K-AS LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma (LUAD) patients Expression(highly expressed) RNA-seq We identified an antisense transcript, LY6K-AS, with elevated expression in lung adenocarcinoma (LUAD) patients, and its higher expression in LUAD patients predicts poor survival outcomes. We identified an antisense transcript, LY6K-AS, with elevated expression in lung adenocarcinoma (LUAD) patients, and its higher expression in LUAD patients predicts poor survival outcomes. Yes LY6K-AS abrogation interfered with the mitotic progression of lung cancer cells resulting in unfaithful chromosomal segregation. LY6K-AS interacts with and stabilizes 14-3-3 proteins to regulate the transcription of kinetochore and mitotic checkpoint proteins. 33674747 LUCAT1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Interaction(ELAVL1/LIN28B/SOX2 Positive Feedback Loop) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Bioinformatics Analysis//ChIP LUCAT1 is significantly overexpressed in TNBC cells. SRY-box transcription factor 2 (SOX2) is an active transcription factor of LUCAT1. LUCAT1 recruits ELAV-like RNA binding protein 1 (ELAVL1) protein to stabilize lin-28 homolog B (LIN28B) mRNA, thereby further modulating SOX2 expression, which forms a positive feedback loop. Yes LUCAT1 interference impedes cell stemness in TNBC cells. 35711895 LUCAT1 LncRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-375) Transfection//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay In the present study, we showed that LUCAT1 was substantially upregulated in glioma tissues and cells. Subsequently, DIANA showed that miR-375 was predicted to contain the complementary binding sites to LUCAT1. Luciferase reporter assay showed that miR-375 directly targeted LUCAT1. In addition, we found that miR-375 was downregulated in glioma tissues and negatively correlated with LUCAT1 expression in glioma tissues. Furthermore, the results showed that miR-375 could rescue the function of LUCAT1 in glioma progression. The lncRNA LUCAT1 was critical for the proliferation and invasion of glioma cells by regulating miR-375. Yes LUCAT1 inhibition significantly suppressed the proliferation and invasion of glioma cells. 29089067 LUCAT1 LncRNA Homo sapiens Thyroid Cancer, Papillary papillary thyroid carcinoma tissues Expression[highly expressed] CCK8//qRT-PCR//cell invasion assay//Western Blot Quantitative reverse transcription PCR was performed to detect the expression levels of 84 lncRNAs in 61 papillary thyroid carcinoma tissues and their adjacent non-tumor tissues. The highest fold-change was obtained for lung cancer associated transcript 1 LUCAT1, and thus, this study determines the expression and biological implication of lncRNA LUCAT1 through different in vitro and ex vivo approaches in this tumor. Yes . Furthermore, LUCAT1 knockdown significantly reduced both cell proliferation and invasion ex vivo and induced cell-cycle arrest and apoptosis. 31591432 circSEPT9 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues regulation[circSEPT9/miR-637/LIF axis] RNA Pull-Down//ISH//qRT-PCR//FISH//RIP//ChIP Increased expression of circSEPT9 was found in TNBC tissues, which was positively correlated with advanced clinical stage and poor prognosis. Our data reveal that the circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer through circSEPT9/miR-637/LIF axis. Increased expression of circSEPT9 was found in TNBC tissues, which was positively correlated with advanced clinical stage and poor prognosis. Yes Knockdown of circSEPT9 significantly suppressed the proliferation, migration and invasion of TNBC cells, induced apoptosis and autophagy in TNBC cells as well as inhibited tumor growth and metastasis in vivo. 32264877 LTSCCAT LncRNA Homo sapiens tongue squamous cell carcinoma CAL27 cells Interaction(miR-103a-2-5p/SMYD3/TWIST1 axis) In Vivo Experiment//IHC//ChIP//Western Blot//ISH//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay//IF . LTSCCAT was upregulated in P.g-LPS-treated CAL27 cells compared with untreated CAL27 cells. We predicted through an online database and confirmed by dual-luciferase reporter assays that LTSCCAT is a competitive endogenous RNA for the regulation of miR-103a-2-5p. Another dual-luciferase reporter assay confirmed that miR-103a-2-5p has a binding site at the 3'-UTR of the histone methylation transferase SMYD3 and inhibits its translation. Chromatin immunoprecipitation experiments demonstrated that SMYD3 binds directly to the promoter region of TWIST1 and promotes its transcription, which is related to H3K4 trimethylation. LncRNA LTSCCAT was upregulated in TSCC patients with periodontitis and was correlated with metastasis and poor prognosis. Yes LTSCCAT induced epithelial-mesenchymal transition and promoted the invasion and metastasis of TSCC in vitro and in vivo. 33542221 circAHNAK1 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues,cell lines Interaction[modulating miR-421 and RASA1] Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that circAHNAK1 was significantly down-regulated in TNBC.Mechanistic analysis indicated that circAHNAK1 acted as a miR-421 ceRNA (competitive endogenous RNA) to attenuate the inhibitory effect of miR-421 on its target gene RASA1. We found that circAHNAK1 was significantly down-regulated in TNBC, and its expression was negatively associated with RFS and OS. Yes Overexpression of circAHNAK1 can inhibit TNBC proliferation, migration and invasion in vitro. In vivo studies confirmed that circAHNAK1 inhibited TNBC tumor growth and metastasis. 31857500 LSINCT5 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[miR-30a/Wnt/β-catenin axis] qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LSINCT5 was significantly up-regulated in BC tissues and cells.The present results uncovered that LSINCT5 knockdown suppressed BC growth and metastasis via the miR-30a/Wnt/β-catenin axis, and it served as a potential therapeutic target for early diagnosis and treatment of BC patients. Yes LSINCT5 knockdown suppressed proliferation, invasion, and epithelial-mesenchymal transition (EMT) in vitro and in vivo. 33490147 LSINCT5 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Regulation[LSINCT5/HMGA2 axis] qRT-PCR//RIP This novel LSINCT5/HMGA2 axis can modulate lung cancer progression and might be a promising target for pharmacological intervention. Increased LSINCT5 expression positively correlates with malignant clinicopathological features and poor survival. Yes LSINCT5 can promote migration and viability of various NSCLC cells in vitro and also enhance lung cancer progression in vivo. 29883241 LSINCT5 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC specimens Interaction(miRNA-185-5p/ZNF703 axis) CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay LSINCT5 was upregulated in OSCC specimens and correlated to poor prognosis of OSCC. LSINCT5 is abnormally upregulated in OSCC specimens and drives its malignant progression through the miR-185-5p/ZNF703 axis. LSINCT5 was upregulated in OSCC specimens and correlated to poor prognosis of OSCC. Yes Knockdown of LSINCT5 inhibited proliferative and migratory capacities of OSCC. 33721442 LSINCT5 LncRNA Homo sapiens Endometrial Neoplasms endometrial carcinoma tissue Regulation[LSINCT5-HMGA2-Wnt/β-catenin signaling pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay The authors observed positively correlated and aberrantly up-regulated LSINCT5 and HMGA2 in EC. Our data uncovered the oncogenic activities and highlighted the mechanistic contributions of the LSINCT5-HMGA2-Wnt/β-catenin signaling pathway in EC. Yes LSINCT5 deficiency significantly inhibited cell proliferation, cell cycle progression, and induced apoptosis. Meanwhile, cell migration and invasion were greatly compromised by the LSINCT5 knockdown. 31632465 LSINCT5 LncRNA Homo sapiens Osteosarcoma OS tissues interaction[EZH2 ] CCK8//qRT-PCR//ChIP//Transwell Assay In our study, we found that LSINCT5 was significantly upregulated in OS tissues than in adjacent normal tissues. Mechanistic exploration revealed that LSINCT5 interacted with EZH2 to suppress the expression of APC, a negative regulator of the Wnt/β-catenin pathway. Additionally, the expression of LSINCT5 was inversely associated with the prognosis of patients with OS. Yes LSINCT5 knockdown dramatically inhibited OS cell proliferation in vitro and tumor growth in vivo. 30420287 LSINCT5 LncRNA Homo sapiens Glioma glioma tissue Regulation[PI3K/AKT, Wnt/β-catenin and NF-κB pathways] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay LSINCT5 was highly expressed while miR-451 low expressed in glioma tissues when compared to normal controls. Down-regulation of LSINCT5 represses glioma cells growth and metastasis in vitro likely through targeting miR-451 and thereby inhibiting Rac1-regulated PI3K/AKT, Wnt/β-catenin and NF-κB pathways. Yes Down-regulating LSINCT5 effectively declined GL15 cells viability, migration and invasion, but accelerated apoptosis. 31213092 LSAMP-1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung 170 cases of NSCLC tissues Interaction(LSAMP/TKI ) CCK8//qRT-PCR//Western Blot We found that Lnc-LSAMP-1 was significantly down-regulated in 170 cases of NSCLC tissues when compared to their adjacent non-cancerous tissues. Chemotherapy sensitization experiments showed that over-expressed Lnc-LSAMP-1 enhanced the inhibition of cell proliferation induced by TKI. Mechanistically, Lnc-LSAMP-1-LSAMP formed a complex which could protect the degradation of LSAMP gene, and thus exerted crucial roles in NSCLC progression and TKI targeted treatment. Loss expression of Lnc-LSAMP-1 was notably correlated with unfavorable prognosis of NSCLC patients. Yes The ectopic expression of Lnc-LSAMP-1 drastically inhibited lung cancer cell proliferation, viability, invasion and migration ability, arrested cell cycle and facilitated apoptosis. 35524253 circITCH CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues,cell lines Interaction[Wnt/β-catenin pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, we characterized the role of circ-ITCH in TNBC and found that circ-ITCH was significantly Expression[down-expression]-regulated in TNBC tissues and cell lines and closely associated with poor prognosis.Mechanistically, we found that circ-ITCH acts as a sponge for miR-214 and miR-17 to increase expression of its ITCH linear isoform, thereby inactivating Wnt/β-catenin signaling. Yes Most importantly, over-expression of circ-ITCH remarkably inhibited TNBC proliferation, invasion and metastasis both in vitro and in vivo. 30509108 hsa_circ_069718 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Interaction[Wnt/β-catenin pathway] CCK8//qRT-PCR//Western Blot//Transwell Assay We found that circRNA_069718 expression was significantly increased in TNBC tissues and cell lines.Mechanically, we found that circRNA_069718 inhibition reduced the expression levels of Wnt/β-catenin pathway-related genes (β-catenin, c-myc, and cyclin D1). High circRNA_069718 expression was significantly correlated with advanced TNM stage, lymph node metastasis, and poor overall survival of TNBC patients. Yes . Functionally, we showed that circRNA_069718 inhibition significantly reduced TNBC cells proliferation and invasion ability in vitro. 31298383 hsa_circ_0004543 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction( hsa_circ_0004543/hsa-miR-217/HIF-1α axis) RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay Our results revealed that the hsa_circ_0004543 expression was considerably increased in CC tissues and cells.The investigation of the mechanism showed that hsa-miR-217 silencing or HIF-1a overexpression rescued hsa_circ_0004543, and silencing inhibited malignant phenotypes of CC cells. hsa_circ_0004543 upregulated the HIF-1α expression by sponging hsa-miR-217 in CC development. Yes Its silencing repressed proliferation and metastasis, while it increased apoptosis of CC cells. 35310917 hsa_circ_0001495 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction(miR-526b-3p/TMBIM6/mTOR axis) In Vivo Experiment//Western Blot//Transfection//EdU Staining//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//IHC//Invasion Assay Our finding showed that hsa_circ_0001495 and TMBIM6 expression were upregulated, while miR-526b-3p was downregulated in CC tissues and cell lines. Hsa_circ_0001495 knockdown or TMBIM6 knockdown suppressed cell proliferation, migration, glycolysis, while promoted cell apoptosis in vitro, and hsa_circ_0001495 silence curbed tumor growth in vivo. Yes Hsa_circ_0001495 knockdown or TMBIM6 knockdown suppressed cell proliferation, migration, glycolysis, while promoted cell apoptosis in vitro, and hsa_circ_0001495 silence curbed tumor growth in vivo. 35533615 circASAP1 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells Interaction(miR-338-3p/RPP25) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay CircASAP1 was overexpressed in cervical cancer tissues and cells compared with negative groups. Mechanistically, circASAP1 could function as a sponge for miR-338-3p to increase the expression of RPP25, and further regulated proliferation, migration, invasion, apoptosis, and cell cycle program of cervical cancer cells, which might be potential markers for cervical cancer diagnosis. Yes Additionally, the loss-of-functional experiments implied that knockdown of circASAP1 impeded proliferation, migration, and invasion while induced apoptosis and cell cycle arrest in cervical cancer cells along with repressed tumor growth in vivo through regulation of miR-338-3p. 34407047 hsa_circ_0084904 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction(miR-802/MAL2 axis) In Vivo Experiment//Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0084904 was markedly up-regulated in CC tissues and cell lines. Mechanistically, circ_0084904 targeted miR-802, and the effects of circ_0084904 silencing were mediated by miR-802. MAL2 was directly targeted and inhibited by miR-802, and MAL2 was a functional target of miR-802. Moreover, circ_0084904 modulated MAL2 expression via miR-802. Yes Silencing endogenous circ_0084904 impeded cell colony formation, cell cycle progression, migration, invasion, epithelial-mesenchymal transition (EMT), and promoted apoptosis in vitro, as well as diminished tumor growth in vivo. 35033901 LRP11-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Interaction( miR-149-3p/NRP2 axis) Western Blot//Wound Healing Assay//qPCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay LRP11-AS1 was found to be significantly overexpressed in TNBC cells compared to the non-TNBC cells and normal mammary epithelial cells. Mechanistically, LRP11-AS1 was found to act as a competing endogenous RNA (ceRNA) to sponge miR-149-3p. Silencing of LRP11-AS1 increased the expression of miR-149-3p and overexpression of miR-149-3p suppressed the expression of LRP11-AS1. Inhibition of miR-149-3p could reverse the anticancer effect of LRP11-AS1 deficiency in TNBC cells. Moreover, Neuropilin-2 (NRP2) was found to be the target of miR-149-3p. Rescue experiments revealed that NRP2 overexpression could rescue the anticancer effect of LRP11-AS1 deficiency in TNBC cells. Yes Knockdown of LRP11-AS1 could inhibit the growth and metastasis of TNBC cells and regulate cell cycle. 35279146 hsa_circ_0009035 CircRNA Homo sapiens Uterine Cervical Neoplasms tumor cells and tissues Interaction(miR-1305/CREBRF axis) In Vivo Experiment//IHC//Western Blot//Transfection//Tube Formation Assay//Invasion Assay//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay First, we found that circ_0009035 expression was significantly upregulated in tumor cells and tissues; second, knockdown of circ_0009035 could inhibit cell proliferation, migration and invasion and promote cell apoptosis. Subsequently, circ_0009035 was found to be able to target miR-1305, and the expression of miR-1305 in tumor tissues and cells was significantly lower. MiR-1305 inhibitor could restore cell-related progression of cervical cancer inhibited by si-circ_0009035. Finally, miR-1305 could target CREBRF, and circ_0009035 could regulate CREBRF expression by targeting miR-1305, thereby affecting cervical cancer tumorigenesis. Yes First, we found that circ_0009035 expression was significantly upregulated in tumor cells and tissues; second, knockdown of circ_0009035 could inhibit cell proliferation, migration and invasion and promote cell apoptosis. 35389936 hsa_circ_0060551 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cells Regulation(TPD52) qRT-PCR//Western Blot According to the results, circ_0060551 was upregulated in cervical cancer cells and could promote the migration and invasion of cells via TPD52. In addition, circ_0060551 could up-regulate TPD52 expression through a ceRNA model to target miR-520a-5p. Moreover, circ_0060551 could stabilize the mRNA expression of TPD52 via recruiting ELAVL1. Yes According to the results, circ_0060551 was upregulated in cervical cancer cells and could promote the migration and invasion of cells via TPD52. 35716110 LUADT1 LncRNA Homo sapiens Small Cell Lung Carcinoma SCLC tissues Interaction[miR-15a-3p] qRT-PCR//Transwell Assay//Western Blot We found that LUADT1 and Twist1 were upregulated in SCLC, while miR-15a-3p was downregulated in SCLC.However, LUADT1 was posively correlated with Twist1 but was not significnatly correlated with miR-15a-3p. Overexpression experiments showed that and LUADT1 and miR-15a-3p did not significantly affect the expression of each other. Yes Transwell assays showed that LUADT1 and Twist1 overexpression mediated the increased rate of cell invasion and migration, while miR-15a-3p overexpression mediated the decreased rate of cell invasion and migration. 31842825 LUADT1 LncRNA Homo sapiens Melanoma melanoma tissues interaction[miR-28-5p,RAP1B] qRT-PCR//Western Blot We found that LUADT1 was upregulated in melanoma and high levels of LUADT1 predicted poor survival. LUADT1 in melanoma and may sponge miR-28-5p to upregulate RAP1B, thereby promoting cancer cell proliferation. We found that LUADT1 was upregulated in melanoma and high levels of LUADT1 predicted poor survival. Yes Cell proliferation assay showed that LUADT1 and RAP1B overexpression mediated the increased proliferation rate of melanoma cells. 32191497 LUADT1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction(miR-1207-5p) In Vivo Experiment//Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Initially, the expression of lncRNA-LUADT1 and TEAD1 were significantly up-regulated in NPC tissues and cells, while miR-1207-5p was significantly down-regulated. Yes The results showed that interfering with lncRNA-LUADT1 expression could inhibit the proliferation, invasion, and migration of NPC cells. 34738862 circIFI30 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells regulation[circIFI30/miR-520b-3p/CD44 axis] RNA Pull-Down//qRT-PCR//RIP//FISH//Luciferase Report Assay We found that circIFI30 was significantly up-regulated in TNBC tissues and cells using quantitative real-time PCR and in situ hybridization. Therefore, our work uncovers the mechanism by which circIFI30 could promote TNBC progression through circIFI30/miR-520b-3p/CD44 axis and circIFI30 could be a novel diagnostic/prognostic marker and therapeutic target for TNBC patients. High circIFI30 expression was positively correlated with clinical TNM stage, pathological grade and poor prognosis of TNBC patients. Yes Functionally, a series of in vivo and in vitro experiments showed that knockdown of circIFI30 could markedly inhibit TNBC cell proliferation, migration, invasion and cell cycle progression, induce apoptosis as well as suppress tumorigenesis and metastasis. 32497020 LUCAT1 LncRNA Homo sapiens Multiple Myeloma cancer tissues,blood regulation[TGF-β Signaling Pathway] qRT-PCR//Western Blot Long noncoding RNA lung cancer-associated transcript 1 was increased in cancer tissues and serum of patients with multiple myeloma as well as multiple myeloma cells, which was correlated with dismal prognosis of patients with multiple myeloma.This study suggests that suppression of long noncoding RNA lung cancer-associated transcript 1 inhibits the activation of transforming growth factor-β signaling pathway, thereby inhibiting the growth of multiple myeloma cells. Yes Overexpression of long noncoding RNA lung cancer-associated transcript 1 promoted the activity of U266 and H929 cells, while inhibition of long noncoding RNA lung cancer-associated transcript 1 suppressed the activity of U266 and H929 cells. 32812490 LUCAT1 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer cell lines Expression [highly expressed] Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//BrdU In comparison to normal cells, LUCAT1 was highly expressed in human pancreatic cancer cell lines (p<0.05). Yes The higher expression of LUCAT1 resulted in enhanced pathogenesis of PDA cells and motivated the development to S phase by regulation of cyclin D1, CDK4. Furthermore, LUCAT1 promoted PDA cells development by inducing AKT's and p38 MAPK's phosphorylation. 33577028 LUCAT1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD serum exosomes, tumor tissues, and LUAD cells Interaction(iR-4316/VEGFA axis) In Vivo Experiment//Western Blot//ISH//Transfection//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay Our findings revealed that lncRNA LUCAT1 was significantly up-regulated in LUAD serum exosomes, tumor tissues, and LUAD cells in comparison with corresponding controls. Furthermore, mechanistic investigations revealed that LUCAT1 elevated LUAD cell metastasis and glycolysis by sponging miR-4316, which further led to the upregulation of VEGFA. Finally, the regulatory axis LUCAT1-miR-4316-VEGFA was verified in LUAD. High expression of LUCAT1 in LUAD patient tissues was associated with enhanced Lymph Node Metastasis (LNM), advanced Tumor Node Metastasis (TNM) stage and poorer clinical outcome in LUAD patients. Yes Knockdown of LUCAT1 inhibited LUAD cell metastasis and glycolysis in vitro as well as tumor metastasis in vivo, while overexpression of LUCAT1 induced a promoted LUAD metastasis and glycolysis. 35646922 LUCAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cell line regulation[inhibition of miR-493] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay The results of the present study revealed that the expression levels of LUCAT1 were upregulated in AMC?HN?8 cells. In conclusion, these results suggested that LUCAT1 may facilitate tumorigenesis in LSCC through the targeted inhibition of miR‑493, which provides evidence for a novel target for the treatment of LSCC. Yes The genetic knockdown of LUCAT1 expression levels significantly suppressed the cell proliferation, alongside downregulating the expression levels of CDK2 and cyclin E1 and upregulating p21 expression levels. In addition, the knockdown of LUCAT1 inhibited cell migration and invasion, as demonstrated using the wound healing and Transwell assays, respectively. 33215214 LUCAT1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Regulation[AKT/GSK-3β Signaling Pathway] qRT-PCR//Western Blot We found that LUCAT1 was significantly upregulated in both clinical ccRCC tissues (n = 90) and TCGA ccRCC tissues (n = 448) compared with normal tissues.These findings indicate that the CXCL2/LUCAT1/AKT/GSK-3β axis is a potential therapeutic target and molecular biomarker for ccRCC. Statistical analysis revealed that the LUCAT1 expression level positively correlated with tumor T stage (P < 0.01), M stage (P < 0.01), and TNM stage (P < 0.01). Overall survival and disease-free survival time were significantly shorter in the high-LUCAT1-expression group than in the low-LUCAT1-expression group (log-rank P < 0.01). Yes LUCAT1 knockdown inhibited ccRCC cell proliferation and colony formation, induced cell cycle arrest at G1 phase, and inhibited cell migration and invasion. Overexpression of LUCAT1 promoted proliferation, migration, and invasion of ccRCC cells. 30032137 LUCAT1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cells Interaction(microRNA-375/YAP1 axis) Northern Blot//Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay The results revealed that LUCAT1 and YAP1 were upregulated and miR-375 was downregulated in ccRCC tissues and cells. LUCAT1 knockdown suppressed cell proliferation, migration and invasion, which were reversed by the inhibition of miR-375. Yes LUCAT1 knockdown suppressed cell proliferation, migration and invasion, which were reversed by the inhibition of miR-375. 34035851 LUCAT1 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC cells and tissues Interaction(miR-375 ) Cell Proliferation Assay//qRT-PCR//Cell Cycle Assay//Migration Assay We showed that the expression of LUCAT1 was up-regulated in the TSCC cells and tissues and the higher LUCAT1 expression was associated with the poor overall survival (OS). In summary, this study suggested the tumorigenic effect of lncRNA LUCAT1 in TSCC cells by targeting miR-375 expression. We showed that the expression of LUCAT1 was up-regulated in the TSCC cells and tissues and the higher LUCAT1 expression was associated with the poor overall survival (OS). Yes Knockdown expression of LUCAT1 suppressed TSCC cell proliferation, cycle and migration. 33787082 LUCAT1 LncRNA Homo sapiens Diabetic Lung Disease blood Interaction[iNOS] qRT-PCR//Western Blot The serum expression level of lncRNA SACL1 was significantly decreased in diabetic patients with diabetic lung disease compared with diabetic patients without lung disease and healthy controls (P<0.05; Fig. 1). ROC curve analysis determined that the area under the curve (AUC) was 0.9233 (95% confidence interval: 0.8679–0.9769) with a standard error of 0.02735 (Fig. 2A). In addition, ROC analysis was used to evaluate the diagnostic value of serum lncRNA SCAL1 in discriminating diabetic patients with diabetic lung disease from diabetic patients without diabetic lung disease. The AUC was 0.8876 (95% confidence interval: 0.8254–0.9498) with a standard error of 0.03174 (Fig. 2B). An AUC>0.65 indicates the potential diagnostic value of a certain indicator for a disease (11). Therefore, serum levels of lncRNA SCAL1 can be used to effectively distinguish diabetic lung patients from healthy controls and diabetic patients without lung disease. Yes Furthermore, the overexpression of SCAL1 inhibited iNOS protein expression and reduced NO production in cells treated with high glucose. 31410144 LUADT1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(microRNA-1207-5p) In Vivo Experiment//Western Blot//Transfection//Invasion Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//Bioinformatics Analysis//Transwell Assay In this study we found that LUADT1 is highly expressed in CC tissues and cells. Mechanistically, LUADT1 binds to miR-1207-5p and inhibits miR-1207-5p expression in CC cells. Septin 9 (SEPT9) is identified as a miR-1207-5p target which is negatively regulated by LUADT1. Overexpression of SEPT9 abrogates the suppressed proliferation of CC cells induced by LUADT1 knockdown. Up-regulated LUADT1 is significantly correlated with the more aggressive status and poorer survival of CC patients. Yes studies show that LUADT1 depletion suppresses CC proliferation, and leads to cell apoptosis and cell cycle arrest. Furthermore, the xenograft mouse assay demonstrates that LUADT1 knockdown remarkably suppresses tumor growth. 35538030 LUCAT1 LncRNA Homo sapiens Hepatoblastoma HB tissues, cell lines Regulation[miR-301b/STAT3 axis] qRT-PCR//Luciferase Report Assay//RIP//Western Blot Quantitative reverse transcription polymerase chain reaction analysis showed that LUCAT1 was highly expressed in both HB tissues and cell lines. Luciferase assays indicated that STAT3 was a transcription activator of LUCAT1 and that LUCAT1 could increase STAT3 expression by competitively binding to miR-301b. Yes Loss-of function assays to identify the biological function of LUCAT1 in HB showed that LUCAT1 knockExpression[down-expression] inhibited cell proliferation, migration, and invasion but reversed epithelial-mesenchymal transition. 30479162 LUCAT1 LncRNA Homo sapiens Urinary Bladder Neoplasms blood,cell lines interaction[targeting miR-199a-5p and miR-199b-5p] qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Transwell Assay In the present study, LUCAT1 was up-regulated in the serum samples of MIBC patients and bladder cancer cell lines, as assessed using real-time PCR. Moreover, LUCAT1 directly targeted miR-199a-5p and miR-199b-5p, as affirmed using the luciferase reporter assay, and manipulation of LUCAT1 significantly suppressed miR-199a-5p and miR-199b-5p. Yes Our in vitro data (including wound healing and trans-well assays) showed that LUCAT1 was required for the proliferation, EMT, migration and invasion processes of T24 cells. 32844284 hsa_circ_0131242 CircRNA Homo sapiens Triple Negative Breast Neoplasms cancer tissues and cell lines interaction[Sponging hsa-miR-2682] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Hsa_circ_0131242 was highly expressed in both cancer tissues and cell lines compared to control. Our study identified hsa_circ_0131242 expression in TNBC for the first time and found that hsa_circ_0131242 may promote triple-negative breast cancer progression by sponging hsa-miR-2682. Subsequently, statistical analyses revealed that high expression of hsa_circ_0131242 was positively correlated with advanced tumor stages and poorer clinical features in cancer patients. Yes Hsa_circ_0131242 knockdown could suppress the progression of breast cancer cells. 32547106 circRPPH1 CircRNA Homo sapiens Triple Negative Breast Neoplasms breast cancer tissues and cell lines regulation[miR-556-5p/YAP1 axis] qRT-PCR//Luciferase Report Assay//RIP PCR results showed that circRPPH1 levels were significantly upregulated in tumor tissues and breast cancer cells. Our data reveal that circRPPH1 plays a vital regulatory role in breast cancer via the miR-556-5p/YAP1 axis and may serve as a promising therapeutic target for breast cancer treatment. Yes Functionally, circRPPH1 promoted the proliferation, migration, invasion, and angiogenesis of breast cancer cell lines and tumor growth in vivo. 33194025 LUCAT1 LncRNA Mus musculus Myocardial Oxidative AMI patient Interaction(miR-181a-5p) Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay LUCAT1 was lowly expressed in the AMI patients. After H2O2 induction, the expression of LUCAT1 in H9c2 cells lessened significantly, while the expression of miR-181a-5p elevated significantly (P < 0.001). LUCAT1 targeted miR-181a-5p and negatively regulated miR-181a-5p expression (P < 0.001). Yes Transfection of p-LUCAT1 significantly reversed the decreased SOD levels, the increased MDA and ROS content, and the elevated tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β) in H2O2-stimulated cells (P < 0.001). Upregulation of LUCAT1 contributed to the mitigation of H2O2 injury by promoting viable cells and repressing apoptotic cells (P < 0.01). 34414854 LUCAT1 LncRNA Mus musculus Glioma glioma cells Regulation(RAS pathway) Western Blot//Transfection//Migration Assay//FISH//qRT-PCR//MTT//IHC//Transwell Assay The expression of LUCAT 1 was up-regulated with an increase in WHO grade, and the lncRNA-mRNA co-expression analysis showed that the expression of ABCB1 was low. LUCAT 1 gene knockout reduced the mRNA and protein levels of Ras signaling pathway related factors (Ras, Raf-1, p-AKT, and p-ERK) as regulating ABCB1 expression and inhibiting the ability of tumor in proliferation and invasion no matter in vitro or in vivo. For overexpressing of LUCAT 1, the opposite was true. After we knocked out ABCB1, the LUCAT1 expression was reversely regulated while the level of RAS signaling pathway related factors increased, and the ability of tumors in proliferation and invasion was enhanced. The abnormal LUCAT1 expression affected the biological behaviors of glioma cells, such as proliferation, invasion, etc. by regulating ABCB1 and promoting the activation of the RAS signaling pathway. This provided a new drug target and therapeutic approach for gene therapy of glioma, which is expected to significantly improve the prognosis of relevant patients. Yes LUCAT 1 gene knockout reduced the mRNA and protein levels of Ras signaling pathway related factors (Ras, Raf-1, p-AKT, and p-ERK) as regulating ABCB1 expression and inhibiting the ability of tumor in proliferation and invasion no matter in vitro or in vivo. For overexpressing of LUCAT 1, the opposite was true. 36270516 circRAD18 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cell lines Regulation[ circRAD18-miR-208a/3164-IGF1/FGF2 axis ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Expression of circRAD18 was found significantly upregulated in TNBC compared with normal mammary tissues and cell lines.Altogether, our research revealed the pivotal role of circRAD18-miR-208a/3164-IGF1/FGF2 axis in TNBC tumorigenesis and metastasis though the mechanism of competing endogenous RNAs. circRAD18 was positively correlated with T stage, clinical stage and pathological grade and was an independent risk factor for TNBC patients. Yes Knockdown of circRAD18 significantly suppressed cell proliferation and migration, promoted cell apoptosis and inhibited tumor growth in functional and xenograft experiments. 31001629 circKIF4A CircRNA Homo sapiens Triple Negative Breast Neoplasms breast cancer cell lines and tissues Expression[highly expressed] qRT-PCR//Microarray qRT-PCR analyses verified that circKIF4A was significantly upregulated and positively associated with poorer survival of TNBC.Luciferase reporter assay and RNA immunoprecipitation assay revealed that circKIF4A and KIF4A could bind to miR-375 and that circKIF4A regulated the expression of KIF4A via sponging miR-375. qRT-PCR analyses verified that circKIF4A was significantly upregulated and positively associated with poorer survival of TNBC. Yes The inhibition of circKIF4A suppressed cell proliferation and migration in TNBC. 30744636 MAGI2-AS3 LncRNA Homo sapiens cervical squamous cell carcinoma CSCC clinical samples and cell lines regulation[miRNA-233/EPB41L3 Axis] qRT-PCR//Luciferase Report Assay//Transwell Assay We found that MAGI2-AS3 and EPB41L3 were both downregulated in CSCC and the expression of this two was positively correlated. MAGI2-AS3 may sponge miR-233 to upregulate EPB41L3, thereby inhibiting CSCC cell invasion and migration. Yes In addition, overexpression of MAGI2-AS3 and EPB41L3 led to inhibited cancer cell invasion and migration, while overexpression of miR-233 played an opposite role and attenuated the effects of overexpressing MAGI2-AS3. 32581592 MAGI2-AS3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation[miRNA-23a-3p/PTEN axis] qRT-PCR//Luciferase Report Assay LncRNA MAGI2-AS3 was downregulated in NSCLC tissues and cell lines.MiRNA-23a-3p was verified to be the target gene of MAGI2-AS3, and furthermore, PTEN was the target of miRNA-23a-3p. Overexpression of miRNA-23a-3p could reverse the inhibited viability and invasion in NSCLC cells overexpressing MAGI2-AS3. Its level was closely related to tumor size, Tumor Node Metastasis (TNM) stage and distant metastasis of NSCLC patients. The worse prognosis was identified in NSCLC patients with low expression of MAGI2-AS3 relative to those with a high expression. Yes Overexpression of MAGI2-AS3 markedly attenuated viability and invasive ability of A549 and PC9 cells. 31539127 MALAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HSCC tissues regulation[microRNA-429,ZEB1] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay MALAT1 and ZEB1 expression in HSCC was upregulated while miR-429 expression was downregulated. Inhibition of MALAT1 was able to elevate miR-429 to suppress the progression of HSCC via reducing ZEB1. Our research provided a potential therapeutic target for HSCC. Yes Reduced MALAT1 and ZEB1, and upregulated miR-429 inactivated the PI3K/Akt/mTOR signaling pathway, suppressed in vitro viability, colony formation ability, migration and invasion, as well as cell growth in vivo, and promoted the apoptosis of FaDu cells. 32980391 hsa_circ_0079593 CircRNA Homo sapiens Glioma cancerous tissues,cell lines(U118、U251、U87MG 、LN229) Interaction[miR-182,miR-433] Wound Healing Assay//qPCR//CCK8//Luciferase Report Assay//Transwell Assay Quantitative real-time polymerase chain reaction (qRT-PCR) was carried out to measure the relative expression of circ_0079593, which was Expression[Expression[up-expression]-expression]regulated in matched cancerous tissues from 60 patients and four cell lines of glioma. Mechanistically, bioinformatics analysis, qRT-PCR, and dual-luciferase reporter assays showed that microRNA 182 (miR-182) and miR-433 could be sponged and negatively regulated by circ_0079593. Further, rescue assays demonstrated that the biological functions of circ_0079593 are dependent on its inhibition of miR-182 and miR-433. A higher level of circ_0079593 in glioma specimens was linked to larger tumor size, higher WHO grade, and worse survival rate for patients with glioma. Yes Exogenous Expression[down-expression]regulation of circ_0079593 expression significantly sExpression[Expression[up-expression]-expression]pressed glioma cell proliferation by increasing cell apoptosis in vitro, and retarded the migratory and invasive potential. 31148222 MALAT1 LncRNA Homo sapiens bronchopulmonary dysplasia Interaction(miR-206) In Vivo Experiment//Transfection//Tunel//qRT-PCR//RIP//Luciferase Report Assay//ELISA In our study, we first found that serum MALAT1 was up-regulated in neonatal BPD and severe BPD. Further, through receiver operating characteristic curve (ROC) analysis, it was found that the area under the curve of MALAT1 for differentiating neonatal BPD from severe BPD was 0.943 and 0.866, respectively. Pathological evaluation confirmed that down-regulating MALAT1 or up-regulating miR-206 might improve the pathological condition of BPD. Furthermore, we also found that MALAT1 has a targeted relationship with miR-206, and miR-206 is down-regulated in BPD in vivo and in vitro. Down-regulating miR-206 could also eliminate the anti-BPD effect after knocking down MALAT1. Yes Then, we established BPD models in vivo and in vitro with C57BL/6J mice and BEAS-2B cells, and found that MALAT1 was also highly expressed in them and increased with the induction time of the models. Obvious inflammatory response, oxidative stress and up-regulated apoptosis were observed in BPD models in vivo and in vitro. However, after MALAT1 knockdown treatment, the above abnormal phenomena were alleviated to varying degrees. 33594304 MALAT1 LncRNA Homo sapiens Coronary Slow Flow Endothelial Dysfunction peripheral blood of the CSF patient (miR-181b-5p-MEF2A-ET-1 axis) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//ELISA//EdU Staining//ChIP MALAT1 and ET-1 were increased, and miR-181b-5p was decreased in the peripheral blood of the CSF patients, and could be used as predictors of CSF. While MEF2A was highly enriched in CSF-induced HUVECs, MEF2A knockdown reduced ET-1 and increased the endothelial function of CSF-induced HUVECs as a transcriptional regulator of ET-1. MALAT1 modulated MEF2A expression positively by sponging miR-181b-5p. Yes In the CSF-induced HUVECs, MALAT1 was highly expressed, and MALAT1 knockdown improved endothelial function. In contrast, miR-181b-5p was downregulated in the CSF-induced HUVECs, and miR-181b-5p overexpression improved endothelial function. 33545365 hsa_circ_0034642 CircRNA Homo sapiens Glioma glioma tissues,cell lines (U118, U251, LN229, and U87MG) Interaction[ circ_0034642/miR-1205/BATF3 pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Circ_0034642 was Expression[Expression[up-expression]-expression]regulated in glioma tissues and cell lines. For the mechanism investigation, circ_0034642 was proved to be a sponge of miR-1205, and miR-1205 could regulate BATF3 expression via targeting 3'UTR of BATF3. Overexpressed circ_0034642 was correlated with adverse phenotypes in the patients with glioma. In addition, circ_0034642 could be regarded as a prognostic predictor for glioma patients. Yes As shown in Fig. 2E, overexpressed circ_0034642 represses cell apoptosis in U251 cells and knockExpression[down-expression] of circ_0034642 increases apoptosis rate in LN229 cells. What's more, transwell assays uncovered that silencing of circ_0034642 attenuated LN229 cell migration and invasion capacities. While Expression[Expression[up-expression]-expression]regulation of circ_0034642 promoted the migration and invasion potential in U251 cells (Fig. 2F). Collectively, circ_0034642 affects cell proliferation, apoptosis, migration and invasion in glioma cells. 30551880 MALAT1 LncRNA Homo sapiens Uterine Cervical Neoplasms tissue and cell lines Interaction(miR-485-5p / MAT2A) Western Blot//ISH//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay In the current study, we documented that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA, is upregulated in HPV16-positive cervical cancer tissue and cell lines. Mechanistically, our results suggested that MALAT1 upregulates Methionine adenosyltransferase 2A (MAT2A) by sponging miR-485-5p. Yes Functionally, the proliferation of cervical cancer was detected by Cell Counting Kit-8 (CCK-8) and colony formation assay in MALAT1 overexpression or knockdown cells, our data showed that MALAT1 promotes the proliferation of cervical cancer cells. 34610246 MALAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(MiRNA-613) qRT-PCR//Luciferase Report Assay//Transwell Assay CEUS of HCC and Pearson correlation analysis showed that CEUS grading and lncRNA MALAT1 were positively correlated in patients with HCC. In HCC tissues of patients with HCC, lncRNA MALAT1 expressed high and miRNA-613 expressed low. The results of bioinformatic analysis showed the targeting of lncRNA MALAT1 and miRNA-613. CEUS of HCC and Pearson correlation analysis showed that CEUS grading and lncRNA MALAT1 were positively correlated in patients with HCC. Yes Knocking down lncRNA MALAT1 could increase miRNA-613 expression significantly, and reduce the migration of HCC cells. Inhibiting miRNA-613 based on knocking down lncRNA MALAT1 could increase the survival and migration of HCC cells. 35706002 MALAT1 LncRNA Homo sapiens Thymus Neoplasms cells Interaction(miR-145-5p/HMGA2 pathway) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay Among the four cell lines evaluated, IU-TAB-1 showed the highest expression of MALAT1; thus, IU-TAB-1 cells were selected for subsequent experiments. After treatment with si-MALAT1 in combination with miR-145-5p mimics or inhibitors, cell proliferation and apoptosis were respectively enhanced and inhibited in IU-TAB-1 cells. miR-145-5p inhibited the luciferase activity of IU-TAB-1 cells transfected with the MALAT1 or HMGA2 3' untranslated region. In conclusion, si-MALAT1 significantly attenuated cell proliferation and apoptosis via the miR-145-5p/HMGA2 pathway in thymic cancer cells. Yes Compared with the findings in the control group, si-MALAT1 significantly decreased the cell proliferation of IU-TAB-1 cells, whereas the apoptosis levels and number of cells in G2 phase were increased. The protein expression levels of cyclin D1, cyclin E, Bcl-2 and HMGA2 were significantly decreased in the si-MALAT1 group compared with those in the control group, while Bax levels were significantly increased. 34122636 MALAT1 LncRNA Homo sapiens Vitiligo Interaction(MALAT1-miR-211-SIRT1 signalling axis) Transfection//Luciferase Report Assay sirtuin1 (SIRT1), an NAD-dependent deacetylase, to be a direct target of miR-211 - the most significantly downregulated microRNA in lesional epidermis. Inhibition of SIRT1 with EX-527 downregulated keratin 10 and involucrin, suggesting that SIRT1 promotes keratinocyte differentiation. Overexpression of miR-211 mimic led to a significant increase in γ-H2AX positivity and cyclobutane pyrimidine dimer (CPD) formation, hallmarks of UVB-mediated DNA damage. These effects could be ameliorated by the addition of resveratrol, a SIRT1 activator. Furthermore, a long noncoding RNA, MALAT1, was identified as a negative upstream regulator of miR-211. Overexpression of MALAT1 resulted in increased expression of SIRT1 and a concomitant removal of UVB-induced CPDs in primary keratinocytes. Yes Overexpression of MALAT1 resulted in increased expression of SIRT1 and a concomitant removal of UVB-induced CPDs in primary keratinocytes. 33152110 MALAT1 LncRNA Homo sapiens Chronic Periodontitis PDLCs Interaction(miR-769-5p/HIF3A Axis) Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//ELISA The expression of MALAT1 and HIF3A was enhanced, and the expression of miR-769-5p was reduced in gingival tissues of patients with CP and LPS-treated PDLCs. MALAT1 knockdown promoted cell viability and inhibited inflammation and cell apoptosis in LPS-treated PDLCs. MALAT1 targeted miR-769-5p and negatively regulated miR-769-5p expression. miR-769-5p overexpression promoted cell viability and inhibited inflammation and cell apoptosis in LPS-treated PDLCs. Besides, miR-769-5p targeted HIF3A and negatively modulated HIF3A expression. Both miR-769-5p inhibition and HIF3A overexpression reversed the inhibitory effects of MALAT1 silencing on LPS-induced PDLC injury in vitro. Yes MALAT1 knockdown promoted cell viability and inhibited inflammation and cell apoptosis in LPS-treated PDLCs. 33604388 MALAT1 LncRNA Homo sapiens Myocarditis mice with AVMC Expression(highly expressed) Flow Cytometry//qRT-PCR//ELISA In the present study, we found that MALAT1 was highly expressed in mice with AVMC, and the expression was correlated positively with cardiac pathological scores, cardiac IL-17 mRNA expression, and the percentages of splenic Th17 cells. In conclusion, our results suggest that MALAT1 knockdown alleviates CVB3-induced AVMC in mice, which may be partially attributable to the decline in Th17 cells responses. In the present study, we found that MALAT1 was highly expressed in mice with AVMC, and the expression was correlated positively with cardiac pathological scores, cardiac IL-17 mRNA expression, and the percentages of splenic Th17 cells. Yes We further demonstrated that MALAT1 knockdown could significantly alleviate the severity of disease and inhibit the differentiation of Th17 cells, accompanying the reduced mRNA expression of RORγt and productions of Th17-related pro-inflammatory cytokines in vivo. Additionally, in vitro analysis showed that MALAT1 knockdown suppressed na?ve CD4+ T cells differentiation towards Th17 cells. 35088199 hsa_circ_0000177 CircRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[Wnt signaling] qRT-PCR//Luciferase Report Assay//Transwell Assay In our study, we found that circRNA hsa_circ_0000177 was upregulated in glioma tissues and cell lines.Through upregulating FZD7 expression, hsa_circ_0000177 activated Wnt signaling and facilitated glioma growth. Also, hsa_circ_0000177 overexpression was associated with poor prognosis in glioma patients. Yes Through functional experiments, we found that hsa_circ_0000177 knockdown dramatically inhibited glioma cell proliferation and invasion in vitro. Consistently, hsa_circ_0000177 knockdown significantly repressed glioma growth in vivo. 30010402 hsa_circ_0001649 CircRNA Homo sapiens Glioma glioma specimens and cell lines Expression[lower expressed] qRT-PCR The data documented a decrease of hsa_circ_0001649 expression in glioma specimens and cell lines. In addition, down-regulated hsa_circ_0001649 is linked to larger tumor size (p = 0.002) and advanced WHO grade (p = 0.023). Additionally, hsa_circ_0001649 may be an independent prognostic marker for glioma patients after surgery (p = 0.046). Yes Moreover, up-regulated hsa_circ_0001649 inhibits glioma cell growth in vitro and in vivo. 30016668 circNFIX CircRNA Homo sapiens Glioma glioma tissue Regulation[miR-34a-5p,Notch Signaling Pathway] Wound Healing Assay//CCK8//qRT-PCR//RIP//Flow Cytometry Of those, circNFIX was the sole circRNA to be overexpressed in glioma among the five methods of finding circRNAs. CircNFIX was markedly upregulated in glioma cells. CircNFIX could regulate NOTCH1 and the Notch signaling pathway to promote glioma progression by sponging miR-34a-5p via the Notch signaling pathway. Yes Downregulation of circNFIX and upregulation of miR-34a-5p both inhibited cell propagation and migration. 30072869 hsa_circ_0074362 CircRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[miR-1236-3p/HOXB7 pathway] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Results demonstrated that hsa_circ_0074362 was significantly upregulated in glioma tissues compared with normal tissues, and hsa_circ_0074362 overexpression was correlated with clinical severity and poor prognosis in patients with glioma. Thus, hsa_circ_0074362 played a crucial role in glioma progression by regulating the miR-1236-3p/HOXB7 pathway. Results demonstrated that hsa_circ_0074362 was significantly upregulated in glioma tissues compared with normal tissues, and hsa_circ_0074362 overexpression was correlated with clinical severity and poor prognosis in patients with glioma. Yes Moreover, hsa_circ_0074362 knockdown remarkably suppressed glioma cell proliferation, migration, and invasion. 30388035 circPTK2 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cell lines Interaction(miR-136/NFIB ) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay CircPTK2 were downregulated in TNBC tissues and cell lines. CircPTK2 significantly promoted the proliferation, migration, and invasion of TNBC cells. CircPTK2 was confirmed to be a sponge of miR-136, and directly regulated NFBI and AKT/PI3K pathway. A rescue assay validated circPTK2/miR-136/NFIB axis in TNBC cells. Yes CircPTK2 significantly promoted the proliferation, migration, and invasion of TNBC cells 35234989 circCSNK1G1 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Interaction(miR-28-5p/LDHA) In Vivo Experiment//IHC//Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ-CSNK1G1 was upregulated in TNBC tissues and cells. Mechanism analysis showed that circ-CSNK1G1 positively regulated LDHA expression by suppressing miR-28-5p. Rescue experiments presented that circ-CSNK1G1 played functions by targeting miR-28-5p, and miR-28-5p participated in TNBC progression by degrading LDHA. Yes Circ-CSNK1G1 knockdown suppressed cancer cell proliferation, migration, invasion and glycolysis energy metabolism, promoted cell apoptosis in vitro, and blocked tumor growth in vivo. 36109751 MALAT1 LncRNA Homo sapiens Lymphoma, T-Cell, Cutaneous CTCL cells Interaction(miR-124) Cell Proliferation Assay//qRT-PCR//ELISA CTCL patients had higher circulating levels of IL-6, IL-8, IL-10, TGFβ, PGE2 and MMP7 which are factors released by tumor-associated macrophages in tumor microenvironment. MALAT1 sponged miR-124 as this tumor suppressive miRNA was de-repressed upon MALAT1 silencing. Moreover, downregulation of miR-124 attenuated MALAT1 silencing effects. Our study provides a rationale for further studies focused on an evaluation of MALAT1-miR-124 in CTCL progression. Yes Such silencing of MALAT1 resulted in reversal of EMT and inhibition of cancer stem cell phenotype, along with reduced cell growth and proliferation. 36059695 circTRIO CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Interaction(miR-432-5p/CCDC58 axis) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//Invasion Assay//Migration Assay//qRT-PCR//circRNA-seq//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay//EdU Staining Mechanistically, a dual luciferase reporter assay and RNA immunoprecipitation were performed and indicated that circ-TRIO could combine with miR-432-5p to regulate the expression of coiled-coil domain containing 58 (CCDC58). Yes Functionally, the knockdown of circ-TRIO inhibited the proliferation, migration and invasion of TNBC cells, while the overexpression of circ-TRIO resulted in the opposite impacts. 36075896 hsa_circ_0000732 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Interaction(miR-1184) Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Our present study found that ERβ2 is upregulated in some TNBC cells and promotes TNBC cell growth, migration and invasion by regulating hsa_circ_0000732 targeting miR-1184. Yes ERβ2 was up-regulated in TNBC tissues and promoted the growth, migration, and invasion of TNBC cells. ERβ2 regulated hsa_circ_0000732 expression by binding to SCARF1 promoter. Knockdown of hsa_circ_0000732 inhibited TNBC cell proliferation, migration, and invasion by upregulating miR-1184. 35064304 Malat1 LncRNA Mus musculus acute myocardial infarction Interaction[miR-125b-5p] qRT-PCR//Western Blot Downregulation of MALAT1 by siRNA transfection attenuated heart damage in an AMI model rat. The mouse cardiomyocyte cell line HL-1 was used to show that downregulation of nucleotide binding and oligomerization domain-like receptor C5 (NLRC5) and upregulation of miR-125b-5p were the results of MALAT1 silencing. TargetScan and a dual-luciferase reporter assay indicated that NLRC5 is a direct target of miR-125b-5p. Overexpression of miR-125b-5p significantly reduced hypoxia/reperfusion-induced apoptosis of HL-1 cells, an effect that could be blocked by NLCR5 overexpression. Taken together, these results suggest that MALAT1 reduced the protective effect of miR-125b-5p on injured cells through upregulation of NLCR5. This study highlights the role of MALAT1 in the pathogenesis of AMI and may guide future genetic therapeutic strategies for AMI treatment. Yes Interestingly, knockdown of MALAT1 strongly decreased the myocardial infarction area in AMI rats as compared with the NC-siRNA group (Fig. 1B). 32010261 MALAT1 LncRNA Homo sapiens Glaucoma RGCs Interaction(miR-149-5p) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay The level of MALAT1 was significantly down-regulated, and the level of miR-149-5p was distinctly up-regulated in RGCs under pressure in a dose-dependent manner. The interaction between MALAT1 and miR-149-5p was predicted by starBase v2.0 online database, and dual luciferase reporter assay, RIP assay and RNA pull-down assay validated the interaction. Yes Functionally, MALAT1 overexpression or miR-149-5p inhibitor alleviated the inhibitory effect on cell viability and the promoted effect on apoptotic rate of RGCs in EIOP. 33108931 hsa_circ_001160 CircRNA Homo sapiens Glioma cell line Regulation[CircRNA_001160/miR-195-5p/ETV1 axis] Northern Blot//ChIP//Western Blot//FISH//qRT-PCR//RIP//Luciferase Report Assay//IF In this study, we found that polypyrimidine tract binding protein 1 (PTBP1) and circRNA_001160 were remarkably Expression[up-expression]regulated in GECs.As a molecular sponge of miR-195-5p, circRNA_001160 attenuated its negative regulation of the target gene ETV1 by adsorbing miR-195-5p. In addition, ETV1 was overexpression in GECs. ETV1 bounded to the promoter regions of tight junction-related proteins and increased the promoter activities, which significantly promoted the expression levels of tight junction-related proteins. The present study showed that the combined application of PTBP1, circRNA_001160, and miR-195-5p with the anti-tumor drug Dox effectively promoted Dox through BTB and extremely induced the apoptosis of glioma cells. Yes Knockdown of PTBP1 or circRNA_001160 significantly increased BTB permeability, respectively. 31862871 MAGI2-AS3 LncRNA Homo sapiens lung squamous cell carcinoma regulation[miR-374a/b-5p/CADM2 Axis] Western Blot//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In conclusion, lncRNA MAGI2-AS3 suppressed LUSC by regulating miR-374a/b-5p/CADM2 axis, which might potentially serve as a therapeutic marker for LUSC patients. Yes MAGI2-AS3 inhibited the proliferative, migratory and invasive capability of LUSC cells with upregulated expression. 32021443 hsa_circ_0005198 CircRNA Homo sapiens Glioma GM tissue,cell line Interaction[miR-1294] qRT-PCR//Luciferase Report Assay The expression of circ_0005198 was enhanced in GM tumors and cells. What's more, circ_0005198 could directly sponge miR-1294 to exert oncogenic functions. Its expression in tumor specimens was related to clinical severity and poor prognosis. Yes Functionally, circ_0005198 could remarkably boost cell growth, clone-forming ability, and metastatic properties and attenuate cell apoptosis in GM cells. 31038801 hsa_circ_0037251 CircRNA Homo sapiens Glioma cell lines Interaction[Sponging miR-1229-3p and Regulating mTOR] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Through in vitro experiments, we discovered that high expression of hsa_circ_0037251 was related to low expression of the microRNA miR-1229-3p and high expression of mTOR. Then, hsa_circ_0037251 was observed to directly sponge miR-1229-3p, and mTOR was identified as a direct target of miR-1229-3p. In addition, knockdown of hsa_circ_0037251 up-regulated the expression of miR-1229-3p and inhibited the expression of mTOR. And overexpression of miR-1229-3p or low-expressed mTOR inhibited the glioma cell progression. Furthermore, transfection with mTOR overexpression vectors can restore the abilities of glioma cell progression even if hsa_circ_00037251 was knocked down using siRNAs. These results indicated that hsa_circ_0037251 may act as a tumour promoter by a hsa_circ_0037251/miR-1229-3p/mTOR axis, and these potential biomarkers may be therapeutic targets for glioma. Yes The over-expressed hsa_circ_0037251 promoted cell proliferation, invasion and migration in glioma, while knockdown of hsa_circ_00037251 promoted cell apoptosis and induced G1 phase arrest. In vivo experiments revealed that hsa_circ_00037251 promoted the growth of xenografted tumours and shortened the survival period. 31875034 circCDC45 CircRNA Homo sapiens Glioma GM tissues,cell lines Interaction[sponging miR-516b and miR-527] qRT-PCR//Luciferase Report Assay High circ-CDC45 expression was found in GM specimens and cells.Stepwise mechanism studies indicated that circ-CDC45 sponged and regulated the expression of miR-516b and miR-527 to promote cell growth and invasion. Briefly, the regulatory network of circ-CDC45/miR-516b/miR-527 plays a pivotal role in GM tumorigenesis and may act as a potential target for GM treatment. High circ-CDC45 expression was found in GM specimens and cells, which was tightly related to a larger tumor size, higher world health organization (WHO) stages, and worse survival for patients with GM. Yes Functionally, manipulation of circ-CDC45 expression strongly affected cell growth, apoptosis, migration and invasion, which suggests the oncogenic function of circ-CDC45 in GM oncogenesis. 31407396 MALAT1 LncRNA Homo sapiens Arthritis, Juvenile sJIA patients Interaction(miR-150-5p/ZBTB4 / JAK/STAT signal pathway) Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//ELISA We found that the expression of MALAT1, the plasma level of pro-inflammatory cytokines (IL-6, IL-17, IL-1β, and TNF-α) as well as MMP-8 and MMP-9 production were significantly elevated in sJIA patients.Furthermore, bioinformatics analysis predicted that MALAT1 might bind to miR-150-5p and ZBTB4 was a downstream target gene of miR-150-5p. Besides, rescue assays revealed that MALAT1 knockdown-mediated suppressive effects on cytokine production could be reversed by ZBTB4 overexpression. In addition, MALAT1 activated the JAK/STAT signaling by upregulating ZBTB4 expression. Yes Moreover, we observed that the production of these cytokines in peripheral blood mononuclear cells (PBMCs) from sJIA patients were reduced after MALAT1 knockdown. 33341002 circPRKCI CircRNA Homo sapiens Glioma glioma tissue and cell lines Interaction[inhibiting miR-545] Western Blot//qPCR//CCK8//RIP//Colony Formation Assay//EdU Staining//Transwell Assay Our results show that circPRKCI is upregulated in human glioma tissues and glioma cells, correlating with downregulation of its potential target, microRNA-545 (miR-545). miR-545 is the primary target of circPRKCI in glioma cells. Forced overexpression of miR-545 mimicked circPRKCI shRNA-induced actions, inhibiting glioma cell survival and proliferation. In contrast, miR-545 inhibition, by a lentiviral antagomiR-545 construct, reversed circPRKCI shRNA-induced anti-A172 cell activity. Importantly, neither circPRKCI shRNA nor circPRKCI overexpression was effective in miR-545-knockout (Cas9 method) A172 cells. Importantly, the subcutaneous and orthotopic A172 xenograft growth was significantly inhibited by circPRKCI silencing. Collectively, circPRKCI promotes human glioma cell progression possibly by inhibiting miR-545. Targeting circPRKCI-miR-545 cascade could efficiently inhibit human glioma cells. Yes In A172 and primary human glioma cells, shRNA-mediated silencing of circPRKCI inhibited cancer cell growth, survival, proliferation, and migration. Conversely, ectopic circPRKCI overexpression promoted A172 cell progression. 31409777 circU2AF1 CircRNA Homo sapiens Glioma glioma tissues and glioma cell lines Interaction[circ-U2AF1/hsa-miR-7-5p/NOVA2 regulatory pathway] qRT-PCR//Luciferase Report Assay We found that the expression levels of circ-U2AF1 and NOVA2 were upregulated, while hsa-miR-7-5p was downregulated in human glioma tissues and glioma cell lines.Our data and bioinformatic analysis indicated the association of these molecules with glioma grade, a positive correlation between circ-U2AF1 and NOVA2 expression levels and a negative correlation of hsa-miR-7-5p with both circ-U2AF1 and NOVA2, respectively. In addition, silencing of circ-U2AF1 expression resulted in increased hsa-miR-7-5p expression and decreased NOVA2 expression both in vitro and in vivo. Luciferase assay confirmed hsa-miR-7-5p as a direct target of circ-U2AF1 and NOVA2 as a direct target of hsa-miR-7-5p. Functionally, silencing of circ-U2AF1 inhibits glioma development by repressing NOVA2 via upregulating hsa-miR-7-5p both in vitro and in vivo. Thus, we assumed that circ-U2AF1 promotes glioma malignancy via derepressing NOVA2 by sponging hsa-miR-7-5p. Taken together, we suggest that circ-U2AF1 can be a prognostic biomarker and the circ-U2AF1/hsa-miR-7-5p/NOVA2 regulatory pathway may be a novel therapeutic target for treating gliomas. Yes Functionally, silencing of circ-U2AF1 inhibits glioma development by repressing NOVA2 via upregulating hsa-miR-7-5p both in vitro and in vivo. 30341906 MALAT1 LncRNA Homo sapiens Venous Thrombosis DVT tissues regulation[Wnt/β-catenin pathway] qRT-PCR//MTT//Transwell Assay//Western Blot The results revealed that MALAT1 was upregulated in DVT tissues. In summary, the data indicated the roles of MALAT1 in the pathogenesis of DVT, and the MALAT1/Wnt/β-catenin axis could be a novel therapeutic target for the treatment of DVT. Yes Furthermore, MALAT1 was able to regulate the biological behaviors of EPCs, including proliferation, migration, cell cycle arrest and apoptosis. 32855682 MALAT1 LncRNA Homo sapiens Venous Thrombosis vascular endothelial cell Interaction(microRNA-383-5p/BCL2L11 axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay There was an interaction between MALAT1 and miR-383-5p. Compared to the control siRNA group, MALAT1-siRNA increased the cell viability, reduced cell apoptosis, upregulated Bcl-2 expression, and suppressed Bax expression. These changes were reversed by the miR-383-5p inhibitor. Additionally, we verified that BCL2L11 is a target of miR-383-5p. miR-383-5p improved the cell proliferation, while decreasing cell apoptosis in HUVECs by targeting BCL2L11. Yes Compared to the control vector group, MALAT1-plasmid suppressed the viability and induced apoptosis of HUVECs, while improving Bcl-2-associated X protein (Bax) expression and decreasing Bcl-2 expression. 35706417 hsa_circ_0001730 CircRNA Homo sapiens Glioma glioblastoma cell lines and tissues Regulation[miR-326/Wnt7B axis] RNA Pull-Down//FISH//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining The levels of circ_0001730 were elevated in glioblastoma cell lines and tissues. SP1 bounds to the promoter of circ_0001730 host gene EPHB4 thereby increasing the expression of circ_0001730. circ_0001730 activated the Wnt/β-catenin pathway via the miR-326/Wnt7B axis. Yes circ_0001730 downregulation suppressed migration and proliferation in glioblastoma cells. 31304776 circPCMTD1 CircRNA Homo sapiens Glioma cell lines Interaction[sponging miR-224-5p] Migration Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay In this study, circPCMTD1 upregulation promoted the cell viability, migration and invasion dramatically, while the inhibition of circPCMTD1 led to a significant reduction of tumor growth in vivo.MiRNAs microarray analyses on circPCMTD1 silencing models in U251 and U118MG cells were performed, and the results suggested that circPCMTD1 knockdown could upregulate the expression of miR-224-5p and downregulate the expression of mTOR, one of miR-224-5p targets, in both cell lines. According to the prediction from circular RNA interactome and Targetscan, there was a complementary sequence in circPCMTD1 for miR-224-5p. Dual-luciferase reporter assay demonstrated that circPCMTD1 were targets of miR-224-5p. RIP assay was also performed to further confirm their directly interaction. Overexpression of miR-224-5p inhibited the viability and proliferation, migration, and invasion of U251 and U118MG glioma cells. In conclusion, circPCMTD1 could contribute to the promotion of glioma progression, and it may serve as the sponge of miR-224-5p to exert its function. Yes In this study, circPCMTD1 upregulation promoted the cell viability, migration and invasion dramatically, while the inhibition of circPCMTD1 led to a significant reduction of tumor growth in vivo. 31179240 circEZH2 CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction[sponging miR-1265] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We identified that circ-EZH2 was overexpressed in glioma tissues and cell lines. Additionally, we found circ-EZH2 served as a miRNA sponge for miR-1265 to release its suppression on DDAH1 and CBX3. Rescue assays further revealed that the oncogenic function of circ-EZH2 was partly dependent on its modulation of DDAH1 and CBX3. Yes Further studies revealed that ectopic expression of circ-EZH2 significantly promoted cell growth, migration and invasion but inhibited cell apoptosis.By contrast, silencing of circ-EZH2 induced the opposite effects. 31669648 MALAT1 LncRNA Homo sapiens Esophageal Neoplasms EC tissues regulation[miR-1-3p/CORO1C/TPM3 axis] qRT-PCR//Luciferase Report Assay MALAT1 level was downregulated, while miR-1-3p level was upregulated in EC specimens. The suppressed level of miR-1-3p not only induced the activity of CORO1C/TPM3 signaling, but also upregulated MALAT1 expression, indicating the reciprocal regulation between the two factors. Yes The inhibition of MALAT1 suppressed the viability, migration, and invasion in EC cell lines. 32468237 circPTN CircRNA Homo sapiens Glioma cell lines Interaction[sponges miR-145-5p/miR-330-5p ] RNA Pull-Down//CCK8//qRT-PCR//FISH//Flow Cytometry//EdU Staining We demonstrated circPTN was significantly higher expression in glioma tissues and glioma cell lines, compared with NBT and HEB (human astrocyte).Furthermore, we performed dual-luciferase reporter assays and RNA pull-down assays to verify that circPTN acts through sponging miR-145-5p and miR-330-5p. Increasing expression of circPTN rescued the inhibition of proliferation and downregulation of SOX9/ITGA5 in glioma cells by miR-145-5p/miR-330-5p. In addition, we found that circPTN promoted self-renewal and increased the expression of stemness markers (Nestin, CD133, SOX9, and SOX2) via sponging miR-145-5p. Moreover, this regulation was disappeared when circPTN binding sites in miR-145-5p were mutated. Yes In gain- and loss-of-function experiments, circPTN significantly promoted glioma growth in vitro and in vivo. 31511040 hsa_circ_0076248 CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction[sponging miR-181a to modulate SIRT1] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Colony Formation Assay//Transwell Assay The quantitative real-time polymerase chain reaction results showed that the expression of miR-181a was significantly decreased in glioma tissues and cell lines compared with normal brain tissues and normal gliocyte, respectively, and the expression of hsa_circ_0076248 and SIRT1 demonstrated the opposite.The experiment also showed that downregulating hsa_circ_0076248 or upregulating miR-181a could remarkably promote the temozolomide chemotherapy sensitivity. Furthermore, Western blot analysis testified that downregulating hsa_circ_0076248 or upregulating miR-181a could promote the expression of p53 and SIRT1. In summary, our study sheds light on the regulatory mechanism of hsa_circ_0076248 in glioma growth and invasion via sponging miR-181a, which downregulates the SIRT1 expression and also suggests that hsa_circ_0076248, miR-181a, and SIRT1 may serve as potential therapeutic targets for glioma. Yes Our results verified that downregulating hsa_circ_0076248 or upregulating miR-181a could depress the proliferation and invasion of glioma in vitro and in vivo. 30506951 circSCAF11 CircRNA Homo sapiens Glioma Glioma Tissue,cell lines Regulation[ miR-421/SP1/VEGFA Axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay circSCAF11 expression was found to be significantly upregulated in the glioma tissue specimens and cell lines. Mechanically, circSCAF11 positively regulated the SP1 expression through sponging miR-421. Moreover, transcription factor SP1 activated the transcription of VEGFA, constructing the circSCAF11/miR-421/SP1/VEGFA axis in the glioma genesis. The ectopic overexpression of circSCAF11 was closely correlated with the poor clinical outcome of glioma patients. Yes Functionally, knockdown of circSCAF11 inhibited the proliferation, invasion, and tumor growth and induced the G0/G1 phase arrest. 31400609 MALAT1 LncRNA Homo sapiens Cerebral Ischaemia/Reperfusion Injury PC12 cells Interaction(miR-182-5p/TLR4 axis) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//H&E Staining MiR-182-5p was validated to be a downstream target gene of MALAT1, and MALAT1 could increase the expression of TLR4 by suppressing miR-182-5p. The effects of PPF on the injury of the mice brain and PC12 cells were partly counteracted by the restoration of MALAT1. PPF protects the brain against I/R-induced injury by regulating MALAT1/miR-182-5p/TLR4 axis. Yes MiR-182-5p was validated to be a downstream target gene of MALAT1, and MALAT1 could increase the expression of TLR4 by suppressing miR-182-5p. The effects of PPF on the injury of the mice brain and PC12 cells were partly counteracted by the restoration of MALAT1. PPF protects the brain against I/R-induced injury by regulating MALAT1/miR-182-5p/TLR4 axis. 34427851 hsa-circ-0014359 CircRNA Homo sapiens Glioma glioma tissues，cell lines Regulation[miR-153/PI3K signaling] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay The expression of circ-0014359 was increased in T98G and SHG44 cancer cell lines and glioma tissues from patients, when compared with control cells and tissue. Further, our observations indicated that circ-0014359 acted as a miRNA-153 (miR-153) sponge in glioma cells. Transfection of miR-153 inhibitor significantly suppressed si-circ-0014359-induced inhibition of cell viability, cell migration, and invasion. The increased expression of circ-0014359 levels in glioma cells was correlated with downregulated expression of miR-153. Overexpression of miR-153 reduced p-AKTser473 (a PI3K pathway indicator) and the rescue experiment showed enhanced p-AKTser473 expression. Yes SiRNA-mediated silencing of circ-0014359 potently inhibited cell viability, migration, invasion, and apoptosis of glioma cells. 30745107 MALAT1 LncRNA Homo sapiens Her2-receptor positive breast cancer cells and tissues Expression [highly expressed] Other As a result, MALAT1 was remarkably up-regulated in HER2-positive breast cancer both in cells and tissues. In addition, the silencing of MALAT1 inhibited the proliferation of HER2-positive breast cancer cells both in vitro and in vivo. Furthermore, knockdown of MALAT1 by shRNA down-regulated DNMT1, DNMT3a, and DNMT3b, while up-regulated BRCA1 and PTEN in HER2-positive breast cancer both in cell lines and mouse xenograft models. Yes In addition, the silencing of MALAT1 inhibited the proliferation of HER2-positive breast cancer cells both in vitro and in vivo. Furthermore, knockdown of MALAT1 by shRNA down-regulated DNMT1, DNMT3a, and DNMT3b, while up-regulated BRCA1 and PTEN in HER2-positive breast cancer both in cell lines and mouse xenograft models. 34148540 MALAT1 LncRNA Homo sapiens Acute Kidney Injury serum samples from AKI patients Interaction(miR-204/APOL1 pathway) RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay From the results, lncRNA MALAT1 was strongly elevated in serum samples from AKI patients, with the high sensitivity and specificity concerning differentiating AKI patients from healthy controls.After co-transfection with MALAT1 silencing and miR-204 inhibition, we found that miR-204 could counteract the effects of MALAT1 on HK-2 cell progression and inflammation after under hypoxic conditions. Finally, NF-κB signaling was inactivated while APOL1 expression was increased in HK-2 cells after hypoxia treatment, and lncRNA MALAT1 inhibition reactivated NF-κB signaling while suppressed APOL1 expression by sponging miR-204. Yes Silencing of MALAT1 could reverse hypoxia-triggered promotion of HK-2 cell apoptosis. Meanwhile, the increase of IL-1β, IL-6, and TNF-α after hypoxia treatment could be repressed by MALAT1 knockdown as well. 34240756 circCPA4 CircRNA Homo sapiens Glioma glioma tissues Regulation[circCPA4/let-7/CPA4 axis] Microarray We found that circCPA4 (hsa_circ_0082374) up-regulated the most in glioma tissues and high levels of circCPA4 were positively related to poor outcome of glioma. Moreover, circCPA4 interacts with let-7 and serves as a sponge for let-7. Through the competitive endogenous RNA (ceRNA) mechanism, circCPA4 sponges let-7 to regulate the expression of CPA4 and glioma progression. The circCPA4/let-7/CPA4 axis regulates glioma progression by ceRNA mechanism, and circCPA4 could be a novel prognostic biomarker and target for glioma treatment. Yes And knockdown of circCPA4 suppresses cell proliferation and metastasis in glioma. 31424161 Malat1 LncRNA Mus musculus Myocardial Infarction MI mice Interaction(MicroRNA-25-3p/CDC42 Axis) In Vivo Experiment//Transfection//Flow Cytometry//FISH//qRT-PCR//MTT//Luciferase Report Assay//IHC//IF MALAT1 was highly expressed in MI mice, OGD-treated MMECs, M1-BMMs, and EVs. MALAT1 sponged miR-25-3p to upregulate CDC42. miR-25-3p overexpression promoted OGD-treated cell viability, proliferation, and angiogenesis. The MEK/ERK pathway was activated after EV treatment. Yes Silencing MALAT1 weakened the inhibition of EV treatment on OGD-treated cells. 34745428 hsa_circ_0001777 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cell line Interaction(miR-95-3p/AKAP12 Axis) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//Invasion Assay//Migration Assay//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//EdU Staining The expression of circ_0001777 and AKAP12 was decreased in TNBC tissues, while the expression of miR-95-3p was increased. Circ_0001777 can sponge miR-95-3p, and AKAP12 is the target of miR-95-3p.Mechanically, circ_0001777 regulates AKAP12 expression in TNBC cells by sponge miR-95-3p. Yes In vitro complement experiments, overexpression of circ_0001777 significantly decreased the malignant behavior of TNBC, while co-transfection of miR-95-3p partially up-regulated this change. In addition, AKAP12 knockdown increased the proliferation, migration, and invasion of TNBC cells inhibited by overexpression of circ_0001777. 36513585 Malat1 LncRNA Mus musculus Sepsis skeletal muscle tissues Interaction[BRCA1,EZH2] Western Blot//FISH//qRT-PCR//RIP//ELISA//ChIP High expression of lncRNA MALAT1 along with low expression of breast cancer susceptibility gene 1 (BRCA1) were identified in septic mice and human skeletal muscle cells of sepsis. Yes Silencing lncRNA MALAT1 resulted in reduced serum levels of interleukin (IL)-6, IL-8, and tumor necrosis factor alpha (TNF-α), neutrophil migration, skeletal muscle cell apoptosis, and AKT-1 phosphorylation. 31830649 Malat1 LncRNA Mus musculus Sepsis mice model Interaction(MALAT1-METTL16-MAT2A interactive axis) qRT-PCR//MeRIP . In cultured macrophages, LPS treatment significantly induced MALAT1 expression, while genetic ablation of MALAT1 greatly reduced proinflammatory cytokine levels. Furthermore, MALAT1-ablated mice had significantly increased survival rates in cecal ligation and puncture (CLP)-induced sepsis and LPS-induced endotoxemia. We showed a mechanism for MALAT1 ablation leading to enhanced antioxidant capacity is through activation of methionine cycle by epitranscriptomical regulation of methionine adenosyltransferase 2A (MAT2A). MAT2A 3'UTR can be methylated by METTL16 which was known to directly bind to MALAT1. MALAT1 ablation was found to reduce methylation in MAT2A hairpin1 and increase MAT2A protein levels. Yes . In cultured macrophages, LPS treatment significantly induced MALAT1 expression, while genetic ablation of MALAT1 greatly reduced proinflammatory cytokine levels. Furthermore, MALAT1-ablated mice had significantly increased survival rates in cecal ligation and puncture (CLP)-induced sepsis and LPS-induced endotoxemia. 35763934 circDHDDS CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and TNBC cell lines Interaction(miR-362-3p/DDX5 ) In Vivo Experiment//IHC//Western Blot//Transfection//Tube Formation Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay The contents of circDHDDS and DDX5 were increased, and miR-362-3p level was decreased in TNBC. Furthermore, miR-362-3p was validated to exert a tumor repressive effect in TNBC cells by suppressing DDX5. Moreover, DDX5 could regulate the development of TNBC. The experimental data exposed that levels of miR-362-3p presented noteworthy negative correlation with circDHDDS and DDX5, while circDHDDS and DDX5 exhibited significant positive correlation. In mechanism, circDHDDS bound to miR-362-3p to modulate DDX5 expression. In addition, circDHDDS knock-down also attenuated tumor growth. Yes CircDHDDS deficiency reserved cell proliferation, migration, invasion and angiogenesis, while facilitated cell apoptosis in TNBC cells. 35343646 MAGI2-AS3 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[highly expressed] qRT-PCR//Wound Healing Assay//Migration Assay The results showed that the expression level of lncRNA MAGI2-AS3 was significantly increased in diffuse gastric cancer tissues compared with intestinal gastric cancer tissues (p < 0.0001; Figure 1B). Moreover, lncRNA MAGI2-AS3 was overexpressed in poorly differentiated gastric cancer tissues compared with moderately or highly differentiated gastric cancer tissues (p < 0.0001; Figure 1C). Furthermore, lncRNA MAGI2-AS3 was more highly expressed in tumors extending beyond the gastric mucosa layer (T2+T3+T4) compared with tumors detected only in the gastric mucosa (T1), and more highly expressed in tumors with a high degree of malignancy (stage II+III+IV) compared with tumors with a low degree of malignancy (stage I; Figures 1D and 1E). Yes Loss-of-function and gain-of-function studies showed that lncRNA MAGI2-AS3 could positively regulate ZEB1 expression and the process of cell migration and invasion in gastric cancer. 31837602 hsa_circ_0062558 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Interaction(miR-876-3p/SLC1A5 axis) In Vivo Experiment//Western Blot//Transfection//Invasion Assay//Migration Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//H&E Staining//Cell Proliferation Assay//IHC//EdU Staining//Transwell Assay TNBC tissues and cells showed the higher level of circ_0062558 when compared with control samples. MiR-876-3p was confirmed as a target of circ_0062558, and circ_0062558 knockdown repressed TNBC cell malignant behaviors by increasing miR-876-3p. Furthermore, miR-876-3p inhibited malignant behaviors of TNBC cells by down-regulating SLC1A5, a newly identified target of miR-876-3p. Yes Downregulation of circ_0062558 inhibited proliferation, migration, invasion, and glutamine metabolism, while enhanced apoptosis of TNBC cells, and silencing of circ_0062558 also inhibited the growth of tumor in vivo. 35284960 MAGI2-AS3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues interaction[sponge miR-25,upregulate RECK] qRT-PCR We found that MAGI2-AS3 and RECK were upregulated and positively correlated in NSCLC.Therefore, MAGI2-AS3 may sponge miR-25 to upregulate RECK, thereby inhibiting NSCLC cell invasion and migration. Yes Cell invasion and migration analysis showed decreased NSCLC cell invasion and migration rates after MAGI2-AS3 and RECK overexpression. 32138716 MAGI2-AS3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues interaction[ Sponging miR-155] qRT-PCR The authors found that MAGI2-AS3 and suppressor of cytokine signaling 1 (SOCS-1) were both downregulated in NSCLC. During follow-up, low levels of MAGI2-AS3 and SOCS-1 were found to be significantly correlated with patients' poor survival. Yes Cell proliferation revealed decreased cell proliferation rate of NSCLC cells after MAGI2-AS3 and SOCS-1 overexpression. 31910343 MAGI2-AS3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-629-5p/TXNIP axis) qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Transwell Assay MAGI2-AS3 was found to be downregulated in NSCLC tissues.The bioinformatics analysis and luciferase report assay revealed that MAGI2-AS3 functioned as competing endogenous RNA to suppress microRNA (miR)-629-5p expression, while miR-629-5p suppressed thioredoxin-interacting protein (TXNIP) expression by targeting its 3' untranslated region. Yes The gain-of-function in vitro studies showed that the overexpression of MAGI2-AS3 suppressed NSCLC cell proliferation and invasion. Conversely, the knockdown of MAGI2-AS3 had the opposite effects. 35071487 MAGI2-AS3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[miR-374b-5p/SMG1 signaling pathway] qRT-PCR In the current study, we found that MAGI2-AS3 expression is downregulated in HCC tissues and closely associated with some clinical characteristics (tumor size, lymph node metastasis, and TNM stage) and poor overall survival.Taken together, we reveal a functional MAGI2-AS3/miR-374b-5p/SMG1 axis that suppresses HCC progression, potently suggesting a new road for HCC treatment. In the current study, we found that MAGI2-AS3 expression is downregulated in HCC tissues and closely associated with some clinical characteristics (tumor size, lymph node metastasis, and TNM stage) and poor overall survival. Yes Overexpression of MAGI2-AS3 inhibits HCC cell proliferation and migration in vitro, while impedes tumor growth in vivo accordantly. 30924168 MAGI2-AS3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction[KDM1A ,H3K4me2 ,RACGAP1 ] Western Blot//Tunel//qRT-PCR//FISH//RIP//IHC//EdU Staining//Transwell Assay MAGI2-AS3 was found to be under-expressed in HCC tissues and cell lines. Interaction between MAGI2-AS3 and KDM1A was identified. KDM1A recruited by MAGI2-AS3 was found to promote H3K4me2 demethylation at the RACGAP1 promoter, which ultimately decreased the expression of RACGAP1. We also identified that RACGAP1 knockdown eliminated the stimulatory effects of MAGI2-AS3 silencing on the malignant phenotypes of HCC cells. Yes The restoration of MAGI2-AS3 was identified to markedly inhibit HCC cell growth, migrating ability, and invasiveness, and promote cell apoptosis. Additionally, the expression of MAGI2-AS3 reduced tumor weight and size in HCC transplanted nude mice. 31629962 MAGI2-AS3 LncRNA Homo sapiens Carcinoma, Hepatocellular blood regulation[ROCK2] Flow Cytometry//qRT-PCR//Western Blot//Transwell Assay We found that MAGI2-AS3 was downregulated in plasma of early stage HCC patients compared to healthy controls. Our study indicated that MAGI2-AS3 was downregulated in the distant recurrence of HCC after surgical resection and affected the invasion and migration of HCC cells via ROCK2. Yes Cell invasion and migration assay showed that overexpression of MAGI2-AS3 mediated the decreased cell invasion and migration rate, while ROCK2 played an opposite role and attenuated the effects of overexpression of MAGI2-AS3. 32546442 MAGI2-AS3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Regulation(miR-519c-3p/TXNIP Axis) qRT-PCR MAGI2-AS3 levels were elevated, and miR-519c-3p decreased in HCC. MAGI2-AS3 overexpression inhibits while its knockdown stimulates HCC cell growth through miR-519c-3p. Moreover, miR-519c-3p overexpression stimulates HCC cell growth. MAGI2-AS3 serves as competing endogenous RNA (ceRNA) of miR-519c-3p to regulate TXNIP in HCC. And, TXNIP upregulation weakened the influence of MAGI2-AS3 knockdown on HCC cell behaviors. Additionally, MAGI2-AS3 overexpression suppressed HCC tumor growth in vivo. Yes MAGI2-AS3 overexpression inhibits while its knockdown stimulates HCC cell growth through miR-519c-3p. 34484334 MAGI2-AS3 LncRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cell lines regulation[miR-31-5p/TNS1 axis] RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//IHC//Transwell Assay Furthermore, we observed significantly lower MAGI2-AS3 and TNS1 mRNA expression and higher miR-31-5p expression in the BCa tissues and cell lines (T24 and J82) compared with their corresponding controls.In conclusion, our study demonstrates that the MAGI2-AS3/miR-31-5p/TNS1 axis regulates BCa progression. Moreover, immunohistochemical staining of paired BCa and normal urothelial tissues showed that low expression of TNS1 correlated with advanced tumor (T) stages and lymph node metastasis in BCa. Yes Functional and biochemical experiments in BCa cell lines including luciferase reporter assays showed that MAGI2-AS3 upregulated TNS1 by sponging miR-31-5p. Transwell assays showed that the MAGI2-AS3/miR-31-5p/TNS1 axis regulated migration and invasion ability of BCa cell lines. 33231563 MAGI2-AS3 LncRNA Homo sapiens Urinary Bladder Neoplasms Bca tissues Regulation(MAGI2/PTEN/epithelial-mesenchymal transition (EMT) axis) qRT-PCR//Western Blot MAGI2-AS3 expression was significantly downregulated in Bca, compared with normal tissues, and negatively associated with tumor stage and a poor prognosis. MAGI2-AS3 overexpression inhibited Bca cell progression by regulating the MAGI2/PTEN/epithelial-mesenchymal transition, offering novel insights into the mechanism of Bca progression. MAGI2-AS3 expression was significantly downregulated in Bca, compared with normal tissues, and negatively associated with tumor stage and a poor prognosis. Yes The expression of MAGI2 and its downstream gene, PTEN, increased in Bca cells overexpressing MAGI2-AS3, and interference by MAGI2 expression reversed the migration and invasion inhibited by MAGI2-AS3 overexpression. 33104021 MAGI2-AS3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck rOSCC and OSCC-LNM Regulation(PI3K-AKT-mTOR pathway) qRT-PCR//Western Blot//Transwell Assay The expressions of the lncRNAs, namely MAGI2-AS3 and CCDC144NL-AS1, were significantly upregulated in rOSCC and OSCC-LNM. MAGI2-AS3 was overexpressed in cancer tissue compared to other control groups. MAGI2-AS3 and CCDC144NL-AS1 might promote cell proliferation, invasion, and migration in OSCC cells by regulating the PI3K-AKT-mTOR pathway. Yes MAGI2-AS3 and CCDC144NL-AS1 might promote cell proliferation, invasion, and migration in OSCC cells by regulating the PI3K-AKT-mTOR pathway. 36401978 hsa_circ_0000851 CircRNA Homo sapiens Triple Negative Breast Neoplasms BC cell lines and tissue samples Interaction( miR-1183/PDK1/p-AKT) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//FISH//Luciferase Report Assay//Cell Proliferation Assay//IHC//Invasion Assay Our study showed that hsa_circ_0000851 was mainly located in the cytoplasm of BC cells and upregulated in BC cell lines and tissue samples. We found that hsa_circ_0000851 bound directly to miR-1183, accelerating the expression of its target gene PDK1, which facilities BC cell proliferation and migration through PDK1/p-AKT. Yes Higher hsa_circ_0000851 expression levels resulted in increased proliferation of BC cells both in vitro and in vivo, while treatment of BC cells with hsa_circ_0000851 siRNA decreased their proliferation. 36241055 MAGI2-AS3 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC cell lines Expression[highly expressed] qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Yes Moreover, MAGI2-AS3 knockdown-suppressed NPC progression in vitro and in vivo. 32450008 circAR-E2E4 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Interaction(miR-665-STAT3 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//PCR//Bioinformatics Analysis Collectively, the regulatory network circAR-E2E4-miR-665-STAT3 axis we constructed was associated with TNBC progression, providing a promising diagnostic, prognostic, and therapeutic target in future treatment for TNBC. Yes CCK-8 assay showed circAR-E2E4 regulated TNBC cell proliferation. 36691537 MAGI2-AS3 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer serum samples and cells Interaction( miR-142-3p) Luciferase Report Assay//Transwell Assay MAGI2-AS3 has descended expression while miR-142-3p has an ascendant one in prostate cancer serum samples and cells. ROC curve analysis revealed that the AUC was 0.953 for MAGI2-AS3, with a sensitivity of 91.5% and specificity of 84.7%. Yes Overexpression of MAGI2-AS3 in LNCaP and PC3 cells suppressed the biological function of the cell including proliferation capacity, migration level, and invasion. 35944561 MAGI2-AS3 LncRNA Homo sapiens Prostatic Neoplasms clinical samples, PC-3 and DU145 cell line Interaction(miR-424-5p/COP1 ) Western Blot//RIP//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Bioinformatics Analysis We found that MAGI2-AS3 was one of the most downregulated lncRNAs in prostate tumors, which was further confirmed in our collected clinical samples. Elevation of MAGI2-AS3 decreased the activity of STAT3 in PC-3 and DU145. In addition, microRNA-424-5p (miR-424-5p), a positive regulator of STAT3 pathway, was predicted as a target of MAGI2-AS3, furthermore, the interaction between MAGI2-AS3 and miR-424-5p was confirmed via reverse-transcript polymerase chain reaction (RT-qPCR), dual luciferase reporter assay and RNA immunoprecipitation (RIP). MAGI2-AS3 upregulated miR-424-5p and downregulated COP1 in PC-3 and DU145. More importantly, IL6-induced activation of STAT3 pathway could attenuate the biological effect of MAGI2-AS3 in PC-3 and DU145. In clinical samples, MAGI2-AS3 levels were negatively correlated with miR-424-5p expression, while positively correlated with COP1 mRNA expression. Yes The function assays showed that MAGI2-AS3 overexpression decreased cell viability and led to obvious cell apoptosis in PC-3 and DU145 prostate cancer cells. 34976194 MAGI2-AS3 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Regulation( HEY1/ACY1 pathway) In Vivo Experiment//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay//ChIP MAGI2-AS3 and ACY1 expression was downregulated in ccRCC tissues, and low expression of MAGI2-AS3 was associated with poor patient survival. The present study demonstrates that MAGI2-AS3 exerts tumor-suppressive, anti-angiogenic activities in ccRCC by modulating the HEY1/ACY1 pathway. MAGI2-AS3 and ACY1 expression was downregulated in ccRCC tissues, and low expression of MAGI2-AS3 was associated with poor patient survival. Yes Overexpression of MAGI2-AS3 could reduce ccRCC cell viability and migration, inhibit vessel-like tube formation of HUVECs in vitro, and repress tumor growth and angiogenesis in vivo. 34002044 MAILR LncRNA Homo sapiens Leukemia, Myeloid, Acute cells Regulation(PDGFA ) qRT-PCR//Luciferase Report Assay//Western Blot Bioinformatics analysis and luciferase assay revealed that H22954 targeted the 3' untranslated region (UTR) of the platelet-derived growth factor subunit A (PDGFA) gene. In transfected cells, H22954 overexpression reduced PDGFA expression and protein levels. These findings indicate that H22954 inhibits angiogenesis in AML through the down-regulation of PDGFA expression. Yes Overexpression of H22954 inhibited angiogenesis in mouse xenograft tumors and cultured acute myeloid leukemia (AML) cells. 35319391 MAILR LncRNA Homo sapiens Leukemia, Myeloid, Acute Bone marrow Expression[lower expressed] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Microarray In this study, we analyzed differentially expressed genes in CD34 hematopoietic cells and identified a novel lncRNA, H22954, which was down-regulated in acute myeloid leukemia (AML) patients. Bioinformatic analysis and RNA antisense purification assay indicated that H22954 targeted the 3' untranslated region of the BCL2 gene. In luciferase assays, H22954 expression inhibited BCL2 expression. In transfected K562 cells and mouse xenograft tumors, H22954 overexpression reduced BCL-2 protein levels and promoted cell death. In AML patients, H22954 expression inversely correlated with BCL-2 protein levels in bone marrow cells, blast cell numbers and disease prognosis. These results indicate that H22954 is a novel regulator of BCL-2 and that reduced H22954 expression may play an important role in the pathogenesis of AML. + Yes In cultured AML cells and mouse xenograft models, H22954 expression inhibited cell proliferation and tumor growth, respectively. 30959078 MAILR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells and tissues regulation[Regulating MiR-513b-5p and DUSP11] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay AZIN1-AS1 was up-regulated in NSCLC cells and tissues, while miR-513b-5p was significantly down-regulated.AZIN1-AS1 acts as a tumor promoter in NSCLC, which is ascribed to the regulation of miR-513b-5p and DUSP11. Yes Silencing of AZIN1-AS1 or overexpression of miR-513b-5p markedly inhibited proliferation, migration and invasion of NSCLC cells, while overexpression of AZIN1-AS1 or inhibition of miR-513b-5p functioned oppositely. 33116570 Malat1 LncRNA Mus musculus Diabetic Gastroparesis DGP model mice Interaction(miR-449a/DLL1 Axis ) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//RNA-seq//migration assay//Luciferase Report Assay//Cell Proliferation Assay We show that MALAT1 expression was upregulated in the gastric tissues of DGP model mice, the adjacent healthy tissues collected from diabetic gastric cancer patients with DGP symptoms, and in HGSMCs cultured under HG conditions. Collectively, our data highlight a novel regulatory signaling pathway, the MALAT1/miR-449a/DLL1 axis, in the context of DGP. Yes Functionally, MALAT1 knockdown in vitro impacted the viability, proliferation, migration and promoted the phenotypic switch of HGSMCs under HG conditions. 34385927 Malat1 LncRNA Mus musculus Neuralgia spinal cord tissue,cell line Regulation[miR‑154‑5p/AQP9 axis] qRT-PCR//ELISA//Luciferase Report Assay//Western Blot The results of the present study identified that the expression levels of MALAT1 and AQP9 were upregulated, while miR‑154‑5p was downregulated in spinal cord tissue and microglia of CCI rats. The present study also identified that miR‑154‑5p was the target gene of MALAT1, and AQP9 was the target gene of miR‑154‑5p. AQP9 knockdown promoted the occurrence of neuropathic pain. In conclusion, lncRNA MALAT1 promotes the progression of neuropathic pain in rats by reducing miR‑154‑5p and increasing AQP9. The MALAT1/miR‑154‑5p/AQP9 axis can be used as a new therapeutic target for neuropathic pain. Yes MALAT1 knockdown in CCI model rats significantly induced the occurrence of neuropathic pain, while the upregulation of miR‑154‑5p could reverse this process. 31746418 Malat1 LncRNA Mus musculus Lung Injury lung tissues Interaction[p38 MAPK/p65 NF-κB pathway] qRT-PCR//Western Blot The expression of lncRNA MALAT1 in lung tissues of mice with septic lung injury was significantly increased (p<0.05).The immunohistochemical results manifested that the knockdown of lncRNA MALAT1 could inhibit the LPS-induced up-regulation of p38 in lung tissues in mice. According to the results of Western blotting, the p38 MAPK/p65 NF-κB signaling pathway was significantly activated in lung tissues in LPS group (p<0.05), while it was significantly suppressed after inhibition on lncRNA MALAT1 (p<0.05). Yes After knockdown of lncRNA MALAT1, the LPS-induced pathological injury of lungs could be improved, and the wet weight/dry weight ratio of lungs could be reduced (p<0.05). 30779099 circEIF3H CircRNA Homo sapiens Triple Negative Breast Neoplasms breast cancer tissues and cells Interaction( IGF2BP2 and HuR /HSPD1, RBM8A, and G3BP1) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//Invasion Assay//Co-IP//Migration Assay//FISH//qRT-PCR//RIP//MTT//RNA-seq//Cell Cycle Assay//Colony Formation Assay//EdU Staining//IF a novel circRNA, circEIF3H, which was upregulated in breast cancer tissues. Large cohort survival analysis confirmed the association between high circEIF3H expression and poor prognosis of TNBC,Further experiments showed that circEIF3H did not function as a microRNA sponge as in the most well-established pathway, but as a scaffold for IGF2BP2 and HuR to regulate the mRNA stability of HSPD1, RBM8A, and G3BP1. a novel circRNA, circEIF3H, which was upregulated in breast cancer tissues. Large cohort survival analysis confirmed the association between high circEIF3H expression and poor prognosis of TNBC, Yes Then we conducted both in vitro and in vivo experiments which illustrated that circEIF3H was essential for TNBC proliferation and metastasis. 35568705 hsa_circ_0076611 CircRNA Homo sapiens Triple Negative Breast Neoplasms (TNBC) cells and tissues Regulation Western Blot//Transfection//Wound Healing Assay//qPCR//RNA-seq//Cell Proliferation Assay//ELISA//Colony Formation Assay//Bioinformatics Analysis//invasion assay Circ_0076611 is detectable in triple-negative breast cancer (TNBC) cells and tissues, in exosomes released from TNBC cells and in the serum of breast cancer patients.Circ_0076611 interacts with a variety of proliferation-related transcripts, included MYC and VEGFA mRNAs, and increases cell proliferation and migration of TNBC cells. Mechanistically, circ_0076611 favors the expression of its target mRNAs by facilitating their interaction with components of the translation initiation machinery. Yes Circ_0076611 interacts with a variety of proliferation-related transcripts, included MYC and VEGFA mRNAs, and increases cell proliferation and migration of TNBC cells. 35710947 Malat1 LncRNA Mus musculus Brain Injuries, Traumatic endothelial cell Regulation In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Tube Formation Assay//qRT-PCR//FISH//Cell Proliferation Assay The results revealed that MALAT1 silencing in vitro inhibited endothelial cell viability and tube formation but increased migration. In MALAT1-deficient mice, endothelial cell proliferation in the injured cortex, functional vessel density and cerebral blood flow were reduced. Bioinformatic analyses and RNA pull-down assays validated enhancer of zeste homolog 2 (EZH2) as a downstream factor of MALAT1 in endothelial cells. Jagged-1, the Notch homolog 1 (NOTCH1) agonist, reversed the MALAT1 deficiency-mediated impairment of angiogenesis. Taken together, our results suggest that MALAT1 controls the key processes of angiogenesis following traumatic brain injury in an EZH2/NOTCH1-dependent manner. Yes The results revealed that MALAT1 silencing in vitro inhibited endothelial cell viability and tube formation but increased migration. In MALAT1-deficient mice, endothelial cell proliferation in the injured cortex, functional vessel density and cerebral blood flow were reduced. 35017438 circDUSP1 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Interaction(miR-761/DACT2 signaling axis) In Vivo Experiment//RNA Pull-Down//qRT-PCR//RIP//Luciferase Report Assay We identified the circRNA named circDUSP1 that was inversely correlated with tumorigenesis and progression in TNBC. In-depth mechanism analysis indicated that circDUSP1 acts as an endogenous sponge of miR-761 to reduce its suppression on target gene DACT2 expression in TNBC. Upregulation of miR-761 or downregulation of DACT2 partially reversed the biological process of TNBC and the prognosis of paclitaxel affected by circDUSP1. Taken together, our findings revealed a role for the regulation of the miR-761/DACT2 axis by circDUSP1 in the biological process of TNBC. Yes Overexpression of circDUSP1 significantly attenuated cell proliferation, migration, invasion, and epithelial-mesenchymal transition, while increased the sensitivity of TNBC cells to paclitaxel. 36562476 Malat1 LncRNA Mus musculus Reperfusion Injury myocardial tissues Regulation[PI3K/AKT signaling pathway ] qRT-PCR//Western Blot//Tunel//H&E Staining The expression level of lncRNA MALAT1 in myocardial tissues was significantly higher in the I/R group than that in the Control group (p<0.05). The MALAT1 knockdown can markedly improve the I/R-induced myocardial injury and promote the cardiac function of rats, whose mechanism may be related to the activation of the AKT signaling pathway by MALAT1 siRNA. Yes The MALAT1 knockdown could significantly improve the cardiac insufficiency caused by I/R injury, and increase both EF% and FS% in rats (p<0.05).In addition, the MALAT1 knockdown could markedly inhibit myocardial infarction caused by I/R injury and reduce the infarction area from (62.12 ± 1.29) to (27.66 ± 3.58; p<0.05). 31841208 Malat1 LncRNA Mus musculus Cerebral Ischaemia/Reperfusion Injury MCAO/reperfusion model and OGD/RX model regulation[miR-145,AQP4] CCK8//qRT-PCR//Flow Cytometry//Western Blot We found that the level of MALAT1 was significantly upregulated in both the MCAO/reperfusion model and OGD/RX model. Taken together, our study confirmed that MALAT1 promotes cerebral ischemia-reperfusion injury by affecting AQP4 expression through competitively binding miR-145, indicating that MALAT1 might be a new therapeutic target for treatment cerebral ischemic stroke. Yes Knockdown of MALAT1 increased cell viability and reduced cell apoptosis in MA-C cells, while an AQP4 siRNA combined with a siRNA targeting MALAT1 could not enhance this effect. 32138732 Malat1 LncRNA Mus musculus Brain Injuries, Traumatic brain microvascular endothelial cells Regulation(Ang1) Western Blot//Migration Assay//qRT-PCR//FISH//Cell Proliferation Assay//IHC Our results indicated that 1) MALAT1 RNA was localized in cerebral endothelium, enhanced by OGD stimuli. 2) Inhibition of MALAT1 by siRNA suppressed angiogenesis, as indicated by endothelial viability, tube formation, migration, and functional vessel density. 3) MALAT1 inhibition further decreased Ang1 expression in the endothelium. 4) Mice with MALAT1 inhibition exhibited worse behavioral performances (NSS, wire grip, Morris water maze), as compared to control. MALAT1 could promote angiogenesis, subsequently contributing to the Ang1 synthesis from active vasculature. It may eventually benefit to functional recovery following TBI. Yes Inhibition of MALAT1 by siRNA suppressed angiogenesis, as indicated by endothelial viability, tube formation, migration, and functional vessel density. 34808123 MALAT1 LncRNA Rattus norvegicus Esophageal Neoplasms PMVECs Interaction(MALAT1/microRNA-144/GSK3β axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tunel//Flow Cytometry//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC//Bioinformatics Analysis Our experimental data revealed that Propofol treatment could decrease the elevated expression of MALAT1 following I/R injury or H/R induction, indicating its protection against lung I/R injury. Additionally, overexpressing MALAT1 or GSK3β promoted the activation of autophagosomes, proinflammatory factor release, and cell apoptosis, suggesting that overexpressing MALAT1 or GSK3β may reverse the protective effects of Propofol against lung I/R injury. MALAT1 was identified to negatively regulate miR-144 to upregulate the GSK3β expression. Yes overexpressing MALAT1 or GSK3β promoted the activation of autophagosomes, proinflammatory factor release, and cell apoptosis, suggesting that overexpressing MALAT1 or GSK3β may reverse the protective effects of Propofol against lung I/R injury. MALAT1 was identified to negatively regulate miR-144 to upregulate the GSK3β expression. 34266379 Malat1 LncRNA Mus musculus Cardiomyopathies cardiomyocytes Regulation(EZH2/miR-22/ABCA1 signaling cascade) In Vivo Experiment//Northern Blot//Western Blot//Tunel//Flow Cytometry//RIP//Luciferase Report Assay//ChIP Silencing of MALAT1 was found to attenuate cardiac dysfunction and inhibit cardiomyocyte apoptosis in db/db mice and HG-cultured mouse cardiomyocytes. MALAT1 recruited the histone methyltransferase EZH2 to the miR-22 promoter region and inhibited its expression. EZH2 induced an increased in the expression of ATP-binding cassette transporter A1 (ABCA1), which was identified to be a target gene of miR-22. Silencing of EZH2 was found to improve cardiac function and prevent cardiomyocyte apoptosis in db/db mice and HG-cultured mouse cardiomyocytes in the presence of MALAT1, suggesting that MALAT1 mediated myocardial damage by recruiting EZH2 to the miR-22 promoter. Taken together, this study's findings provide evidence confirming our hypothesis, suggesting the involvement of MALAT1 in the processes of cardiac function and cardiomyocyte apoptosis via the EZH2/miR-22/ABCA1 signaling cascade, which has potential therapeutic implications for the understanding of diabetic cardiomyopathy. Yes Silencing of MALAT1 was found to attenuate cardiac dysfunction and inhibit cardiomyocyte apoptosis in db/db mice and HG-cultured mouse cardiomyocytes. 33097254 Malat1 LncRNA Mus musculus Acute Lung Injury smoke-induced ALI in mice Regulation( SOCS-1 ) In Vivo Experiment//qRT-PCR//ELISA//Western Blot In conclusion, the results pointed out that HA1600 exerted a protective effect against smoke-induced ALI through increasing the MALAT1 level and the subsequent SOCS-1 expression. Yes Next, we overexpressed MALAT1 in the lungs by intratracheal administration of adenovirus cloned with MALAT1 cDNA and found that the survival of mice after smoke exposure was improved. Moreover, pulmonary overexpression of MALAT1 ameliorated smoke-induced ALI in mice and elevated the level of SOCS-1 in the lungs. 35807375 Malat1 LncRNA Mus musculus Renal Ischemia/Reperfusion Injury murine hypoxic kidney tissue, hypoxic endothelial cells and tubular epithelial cells Expression [highly expressed] In Vivo Experiment Malat1 was upregulated in kidney biopsies and plasma of patients with AKI, in murine hypoxic kidney tissue as well as in cultured and ex vivo sorted hypoxic endothelial cells and tubular epithelial cells. Yes In vitro, Malat1 inhibition reduced proliferation and the number of endothelial cells in the S-phase of the cell cycle. In vivo, Malat1 knockout and wildtype mice showed similar degrees of outer medullary tubular epithelial injury, proliferation, capillary rarefaction, inflammation and fibrosis, survival and kidney function. 29467431 circUBR5 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Interaction(circUBR5/miR-1179/UBR5 axis ) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay In this study, we detected higher expressions of both circUBR5 and UBR5 in TNBC tissues, which were associated with worse prognosis, and also in a panel of breast cancer cells, particularly in TNBC cells. Mechanistically, the oncogenic phenotypes of circUBC5 were mediated through sponging miR-1179 and up-regulating UBR5. In this study, we detected higher expressions of both circUBR5 and UBR5 in TNBC tissues, which were associated with worse prognosis, and also in a panel of breast cancer cells, particularly in TNBC cells. Yes Functionally, circUBR5 was crucial for sustaining the malignant growth and metastasis of TNBC cells both in vitro and in vivo. 35812044 MALAT1 LncRNA Rattus norvegicus Acute Lung Injury LPS-induced ALI rat model Interaction(miR-146a) In Vivo Experiment//qRT-PCR//RIP//Luciferase Report Assay//ELISA The results revealed that MALAT1 knockdown played a protective role in the LPS-induced ALI rat model. This study found that MALAT1 acts as a molecular sponge for miR-146a and MALAT1 negatively regulated miR-146a expression. Mechanistically, MALAT1 overexpression alleviated the inhibitory effect of miR-146a on LPS-induced inflammatory response in MH-S. Yes In addition, knockdown of MALAT1 in vitro inhibited LPS-induced inflammatory response in murine alveolar macrophages cell line MH-S and murine alveolar epithelial cell line MLE-12. 29649906 MALAT1 LncRNA Rattus norvegicus Subarachnoid Hemorrhage mouse primary neurons Interaction(miR-499-5p/SOX6 axis) In Vivo Experiment//Western Blot//Transfection//Tunel//qRT-PCR//RIP//MTT//Luciferase Report Assay MALAT1 was found upregulated in brain tissues of SAH mice and OxyHb-stimulated neurons. In addition, knockdown of MALAT1 attenuated apoptosis and decreased reactive oxygen species (ROS) production in OxyHb-stimulated neurons. Mechanistically, we demonstrated that MALAT1 bound with miR-499-5p. Furthermore, our findings indicated that miR-499-5p bound to SOX6 3' untranslated region (UTR) and negatively regulated SOX6 mRNA and protein levels. Rescue assays suggested that SOX6 overexpression counteracted the effects of MALAT1 knockdown on neurocyte apoptosis, and ROS production in OxyHb-stimulated neurons. The in vivo assays indicated that knockdown of MALAT1 improved brain injury of SAH mice. Yes knockdown of MALAT1 attenuated apoptosis and decreased reactive oxygen species (ROS) production in OxyHb-stimulated neurons.Rescue assays suggested that SOX6 overexpression counteracted the effects of MALAT1 knockdown on neurocyte apoptosis, and ROS production in OxyHb-stimulated neurons. The in vivo assays indicated that knockdown of MALAT1 improved brain injury of SAH mice. 34709490 MALAT1 LncRNA Rattus norvegicus Cerebral Small Vessel Diseases A rat model of diabetes Interaction(miR-7641/TPR axis ) In Vivo Experiment//qPCR//Bioinformatics Analysis High blood glucose level induced the increase of lncRNA MALAT1 and regulated the expression of TPR by activating miR-7641 to promote the initiation of apoptosis of microvascular endothelial cells, aggravating the neurological dysfunction caused by CSVD. Yes High blood glucose level induced the increase of lncRNA MALAT1 and regulated the expression of TPR by activating miR-7641 to promote the initiation of apoptosis of microvascular endothelial cells, aggravating the neurological dysfunction caused by CSVD. 35071456 LINC02933 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction(RAD54B/PI3K/AKT Axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Our data showed high expression of lncRNA AC012213.3 in breast cancer tissues and cell lines. The high expression of the AC012213.3 was associated with the worse prognosis and clinical features. Besides, in vitro assays demonstrated that downregulation of AC012213.3 suppresses the proliferation and invasion of breast cancer cells. Further analysis showed that RAD54B is a downstream AC012213.3 target gene and was upregulated in breast cancer. lncRNA AC012213.3 is upregulated in breast cancer and could enhance breast cancer progression through RAD54B/PI3K/AKT axis. Yes Besides, in vitro assays demonstrated that downregulation of AC012213.3 suppresses the proliferation and invasion of breast cancer cells. 34557038 LINC02925 LncRNA Homo sapiens Glioblastoma GBM tumor Interaction(miR-139-5p/NR5A2 axis.) Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay//Transwell Assay NR5A2 was upregulated in the three independent GBM tumor cohorts. Further in vitro experiments revealed that RP3-439F8.1 acts as a competing endogenous RNA (ceRNA) to regulate NR5A2 by sponging the microRNA miR-139-5p. Yes In vitro, NR5A2 overexpression enhanced GBM cell proliferation, colony formation, invasiveness, and G0-G1 cell cycle phase shift via co-activating β-catenin/TCF4 signaling, with no apparent effect upon apoptosis. In contrast, RP3-439F8.1 knockdown produced the opposite effects. RP3-439F8.1 knockdown reduced tumor progression in vivo, increasing overall survival in model mice. 33991848 LINC00294 LncRNA Homo sapiens Glioma GBM tissues and glioma cell lines interaction[miR-1278] CCK8//qRT-PCR//EdU Staining//RIP A new lncRNA, LINC00294, was highly expressed in normal brain tissues. However, it was markedly down-regulated in GBM tissues and glioma cell lines.Collectively, our observations demonstrate the tumor-suppressive function of LINC00294 in glioma development by sponging miR-1278 and promoting NEFM, suggesting a potential use in therapy for glioma. Yes Overexpression of LINC00294 abates glioma cell proliferation but induces apoptosis. 32450002 LINC00665 LncRNA Homo sapiens lung non-small cell carcinoma (NSCLC) tissues Interaction(EZH2 ) IHC//Western Blot//Transfection//qPCR//Flow Cytometry//RIP//migration assay//Cell Proliferation Assay//Colony Formation Assay//EdU Staining//ChIP Herein, we report that lncRNA linc00665 is significantly upregulated in non-small cell lung cancer (NSCLC) tissues compared with adjacent normal tissues. Further work revealed that linc00665 could recruit enhancer of zeste homolog 2 (EZH2) to the promoter region of cyclin-dependent kinase inhibitor 1C (CDKN1C) to inhibit its transcription and thus carry out its tumorigenic role. Yes Functional experiments showed that linc00665 enhanced the proliferation and migration of NSCLC cells in vivo and in vitro, and knocking down linc00665 could enhance the drug sensitivity of NSCLC cells to DDP. 33664990 LINC00662 LncRNA Homo sapiens Breast Neoplasms breast cancer cell lines and tissue regulation[miR-497-5p/EglN2 axis] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that LINC00662 was overexpressed in both breast cancer cell lines and tissue compared to normal breast cell lines and healthy breast tissue. Overall, our results demonstrated that overexpression of LINC00662 accelerated the malignant growth of breast cancer cells via sponging miR-497-5p and upregulating EglN2 expression, and indicate that targeting LINC00662 may represent a novel strategy for breast cancer therapy. Yes Furthermore, LINC00662 silencing reduced cell viability and inhibited the proliferation, migration and invasion of MDA-MB-157 cells. 32558530 LINC00662 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung plasma exosome of NSCLC patients Interaction(miR-320d/E2F1 axis) Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Significantly, we revealed that the expression of lncRNA LINC00662 was elevated in the plasma exosome of NSCLC patients. Exosomal LINC00662 promoted proliferation, invasion, and migration, and inhibited apoptosis and cell cycle arrest of NSCLC cells. Yes Exosomal LINC00662 contributed to the progression of NSCLC by miR-320d/E2F1 axis in vitro. Remarkably, exosomal LINC00662 enhanced the tumor growth of NSCLC in vivo.  33589572 LINC00662 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation(EZH2/BIK cell axis) qRT-PCR//ChIP//RIP//Western Blot Here, through systematic bioinformatics analysis and screening, we identified a long noncoding RNA LINC00662 with high copy number amplification in NSCLC. Mechanically, we obtained global expression profile that respond to LINC00662 knockdown through RNA-Seq analysis. And we found that LINC00662 could bind to EZH2 and recruit EZH2 to the promoter regions of BIK, regulating the level of H3K27me3 in the BIK promoter, thus epigenetically repressing BIK expression. High expression of LINC00662 predicted a poorer survival. Yes The exact sequence full-length of LINC00662 was determined by rapid amplification of cDNA ends (RACE). We also found that LINC00662 could regulate lung cancer cell proliferation both in vitro and in vivo. 35371316 LINC00662 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues regulation[miR-340-5p,HOXB2] qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Upregulation of LINC00662 was found in ESCC and associated with worse clinical outcomes in ESCC patients.LncRNA LINC00662 promotes the progression of ESCC by upregulating HOXB2 by sponging miR-340-5p. Yes More importantly, knockdown of LINC00662 restrained cell proliferation, migration and invasion in ESCC. 32633082 LINC00662 LncRNA Homo sapiens Lung Neoplasms regulation[miR-145-5p-PAFAH1B2 axis] qRT-PCR The lncRNA linc00662 is overexpressed in lung cancer.We further show that linc00662 binds with miR-145-5p, and that miR-145-5p binds to the 3'UTR of PAFAH1B2. miR-145-5p negatively regulates PAFAH1B2 both at the mRNA and the protein level. Yes We knocked-down the expression of linc00662 using siRNA, and found that silencing linc00662 significantly inhibited the proliferation and colony formation of the lung cancer cell lines A549 and H460. 33108738 LINC00662 LncRNA Homo sapiens Colorectal Neoplasms colon cancer tissues and cell lines interaction[CLDN8/IL22,miR-340-5p] RNA Pull-Down//Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LINC00662 was up-regulation in colon cancer tissues and cell lines. LINC00662 overexpression promoted the occurrence and development of colon cancer by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and activating ERK signaling pathway. Univariate Cox regression analysis showed that the LINC00662 expression level was related to the poor prognosis. Yes LINC00662 overexpression promoted cell proliferation, invasion and migration, and inhibited cell apoptosis in colon cancer. 31900207 LINC00662 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[Wnt/β-catenin signaling] RNA Pull-Down//Northern Blot//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//ELISA//IHC//Invasion Assay//IF LINC00662 was found to be upregulated in HCC, and high LINC00662 levels correlated with poor survival of HCC patients.Through inducing WNT3A secretion, LINC00662 activated Wnt/β-catenin signaling in HCC cells in an autocrine manner and further promoted HCC cell proliferation, cell cycle, and tumor cell invasion, while repressing HCC cell apoptosis. LINC00662 was found to be upregulated in HCC, and high LINC00662 levels correlated with poor survival of HCC patients. Yes Via activating Wnt/β-catenin signaling and M2 macrophages polarization, LINC00662 significantly promoted HCC tumor growth and metastasis in vivo. 31785055 LINC00662 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells regulation[miR- 375/HIF-1α axis ] qRT-PCR//Luciferase Report Assay//RIP Results showed that LINC00662 was highly expressed in OC tissues and cells, and patients with increased expression of LINC00662 were associated with shorter overall survival. Results showed that LINC00662 was highly expressed in OC tissues and cells, and patients with increased expression of LINC00662 were associated with shorter overall survival. Yes Furthermore, functional assays proved that LINC00662 was essential for OC cell proliferation and glycolysis. 32476381 LINC00662 LncRNA Homo sapiens Ovarian Neoplasms OC patients Interaction(GRP78/p38 pathway) qRT-PCR//Western Blot LINC00662 overexpression is highly associated with malignant features in OC patients and is a prognostic indicator. Mechanistically, LINC00662 is stabilized by heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1). Moreover, LINC00662 exerts oncogenic effects by interacting with glucose-regulated protein 78 (GRP78) and preventing its ubiquitination in OC cells, leading to activation of the oncogenic p38 MAPK signaling pathway. LINC00662 overexpression is highly associated with malignant features in OC patients and is a prognostic indicator. Yes LINC00662 significantly promotes OC cell proliferation and metastasis in vitro and in vivo. 34148056 LINC00662 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Regulation[Wnt/β-catenin signaling] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//EdU Staining//Transwell Assay We found that the expression of LINC00662 was significantly increased in OSCC tissues. Furthermore, LINC00662 regulated the Wnt/β-catenin pathway. We found that the expression of LINC00662 was significantly increased in OSCC tissues, and a higher expression of LINC00662 was detected in larger tumor size, higher stage tumors and with lymph node metastasis. Yes Moreover, overexpression of LINC00662 induced OSCC cell proliferation, increased migration and invasion abilities, and suppressed cell apoptosis. Knockdown of LINC00662 decreased the proliferation, migration, and invasion abilities of OSCC cell, and induced apoptosis. 30705593 LINC00662 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Interaction(miR-144-3p/EZH2 Axis) qRT-PCR//Luciferase Report Assay//Transwell Assay The expression of LINC00662, positively associated with the increased TNM stage and lymph node metastasis of the patients, was up-regulated in OSCC tissues and cells. MiR-144-3p could bind to LINC00662, and the promoting effect of LINC00662 overexpression was counteracted by miR-144-3p mimic. Moreover, EZH2 expression was negatively regulated by miR-144-3p and positively regulated by LINC00662. The expression of LINC00662, positively associated with the increased TNM stage and lymph node metastasis of the patients, was up-regulated in OSCC tissues and cells. Yes The overexpression of LINC00662 facilitated the proliferation, migration, and invasion of OSCC cells. The silencing of EZH2 attenuated the promoting effects of overexpression of LINC00662 on cell proliferation, migration, invasion, and epithelial-mesenchymal transition. 34164962 LINC00662 LncRNA Homo sapiens Osteosarcoma OS tissues regulation[ miR-15a-5p/Notch2 axis] Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expression of LINC00662 and Notch2 was found to be upregulated in OS, but the expression of miR-15a-5p was downregulated. The study demonstrated that LINC00662 could be a potential biomarker for OS therapy, and LINC00662 knockdown suppressed the proliferation, migration, and invasion of OS cells by regulating the miR-15a-5p/Notch2 axis. Yes The results demonstrated that LINC00662 knockdown attenuated the proliferation, migration, and invasion of OS cells and suppressed tumor growth in mice. 32848412 LINC00662 LncRNA Homo sapiens Osteosarcoma OS cells Interaction(miR-103a-3p/SIK2 axis) qRT-PCR//RIP//Western Blot In this study, we found that LINC00662 displayed high expression in OS cells.Subsequently, miR-103a-3p was proven to bind with LINC00662 and overexpression of miR-103a-3p inhibited OS cell proliferation, migration and invasion. Then, SIK2, the downstream of miR-103a-3p, was up-regulated in OS cells and positively regulated by LINC00662. Yes LINC00662 down-regulation negatively affected OS cell malignant behaviors and tumor growth. 34559955 LINC00662 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-16-5p/ITPR1 Axis) qRT-PCR//Western Blot In the present study, our findings demonstrated the upregulation of LINC00662 expression in OS tissues and cells, and high expression of LINC00662 predicted a poor clinical prognosis of patients' iNOS.Further mechanistical investigations indicated that LINC00662 functioned as a competing endogenous RNA (ceRNA) for sponging microRNA-16-5p (miR-16-5p) to upregulate the expression of IP receptor type 1 (ITPR1) in OS cells. Restoration assays validated the involvement of ITPR1 in LINC00662-mediated regulation of cell functions in OS. In the present study, our findings demonstrated the upregulation of LINC00662 expression in OS tissues and cells, and high expression of LINC00662 predicted a poor clinical prognosis of patients' iNOS. Yes Through a series of in vivo assays, LINC00662 knockdown suppressed OS cell proliferation, invasion, migration, and stemness property maintenance. 34621314 LINC00662 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells Interaction(miR-30b-3p/ELK1 ) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//IHC//Transwell Assay LncRNA LINC00662 and ELK1 were significantly increased, while miR-30b-3p was reduced in osteosarcoma tissues. LncRNA LINC00662 also appeared to sponge miR-30b-3p in order to affect the expression of ELK1. Simultaneously, there were weak negative correlations between the expression of miR-30b-3p and LINC00662/ELK1 in osteosarcoma tissues. Rescue experiments suggested that ELK1 overexpression and downregulation of miR-30b-3p reversed the suppressive effects of sh-LINC00662 on the cell migration, invasion, and proliferation in osteosarcoma. Yes The results of functional experiments indicated that transfection of small hairpin (sh)-LINC00662 and miR-30b-3p mimics repressed the migration, invasion, and proliferation of osteosarcoma cells. 35123530 LINC00662 LncRNA Homo sapiens Glioma glioma tissues regulation[miR-34a-5p/LMAN2L Axis] Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Our study was the first to report that LINC00662 acted as a competing endogenous RNA (ceRNA) to regulate glioma progression by targeting miR-34a-5p/LMAN2L axis, providing a new therapeutic target for glioma. High LINC00662 level predicted poor overall survival of glioma patients. Yes Functional studies revealed that suppression of LINC00662 remarkably inhibited cell proliferation, clonogenicity and EMT pathway. 33116598 LINC00662 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Interaction[targeting miR-34a] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LINC00662 was significantly upregulated in PCa tissues and cell lines compared with adjacent normal tissue and a normal prostate epithelial cell line. Also, the results of RT-PCR showed that knockdown of LINC00662 suppressed the expression levels of miR-34a. Yes Furthermore, LINC00662 silencing inhibited the proliferation, migration, and invasion of PC-3 and LNCaP cells, and promoted apoptosis in vitro. 31114993 LINC00662 LncRNA Homo sapiens Prostatic Neoplasms PCa tissue and cell lines Expression[highly expressed] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay The expression of Linc00662 in the PCa tissue and cell lines was significantly up-regulated compared with that in the adjacent normal prostatic tissue and epithelial cells (P < 0.01), and the high expression of Linc00662 was positively correlated with the tumor stage (P = 0.002), primary tumor size (P = 0.006), lymph node metastasis (P = 0.001) and distant metastasis (P = 0.001). The expression of Linc00662 in the PCa tissue and cell lines was significantly up-regulated compared with that in the adjacent normal prostatic tissue and epithelial cells (P < 0.01), and the high expression of Linc00662 was positively correlated with the tumor stage (P = 0.002), primary tumor size (P = 0.006), lymph node metastasis (P = 0.001) and distant metastasis (P = 0.001). Yes Compared with the normal control, the PC-3 and DU145 cells in the Linc00662 interference group showed remarkably decreased proliferation, invasion and migration abilities (P < 0.01), but an increased rate of apoptosis (P < 0.01). 33377712 LINC00663 LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation(AKT/mTOR pathway) Western Blot//Bioinformatics Analysis//Transfection//CCK8//qRT-PCR//EdU Staining//Transwell Assay LINC00663 expression was higher in both glioma tissues and cell lines than that in the normal brain tissues and human astrocytes. High expression of LINC00663 led to the low overall survival rate of patients with glioma. Yes LINC00663 knockdown notably restrained cell proliferation, migration, and invasion abilities by decreasing the activation of AKT and mTOR. 33830405 LINC00665 LncRNA Homo sapiens Melanoma melanoma cells Interaction(miR-224-5p/VMA21 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay LINC00665 was abnormally highly expressed in melanoma cells. LINC00665 sponged miR-224-5p to upregulate VMA21. VMA21 knockdown exerted similarly interfering effects on above biological processes in melanoma cells. However, VMA21 overexpression abolished the in vitro and in vivo outcomes of LINC00665 silencing. LINC00665 promotes proliferative and migrating abilities of melanoma cells via targeting miR-224-5p/VMA21 axis. Yes Silencing LINC00665 could inhibit the proliferation and migration of melanoma cells. 33247967 LINC00659 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Expression [highly expressed] Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Invasion Assay LINC00659 expression was significantly upregulated in GC tissues and cell lines. Increased levels of LINC00659 were associated with advanced tumor stage and unfavorable prognosis of patients with GC. Yes Additionally, upregulated LINC00659 expression promoted the migration and invasion of GC cells 34084224 LINC00667 LncRNA Homo sapiens Breast Neoplasms BC cell and patients Interaction(m6A/KIAA1429 positive feedback loop) Western Blot//Migration Assay//RIP//qRT-PCR//Luciferase Report Assay//Cell Viability Assay In the current study, we found that LINC00667 was m6A-modified lncRNA, which was up-regulated upon the overexpression of KIAA1429. Mechanistic assays illustrated that KIAA1429 targeted the m6A modification site of LINC00667 and enhanced its mRNA stability. Moreover, LINC00667 positively regulated the KIAA1429 via sponging miR-556-5p, forming a KIAA1429/m6A/LINC00667/miR-556-5p feedback loop. The high expression of LINC00667 was correlated with the prognosis of BC patients. Yes Bio-functional assays indicated that LINC00667 promoted the proliferation and migration of BC cells. 36700472 LINC00667 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung regulation[stabilizing VEGFA by EIF4A3] qRT-PCR Our study was the first to illustrate that LINC00667 was upregulated in NSCLC and LINC00667 silence refrained the proliferation, migration, and angiogenesis of NSCLC cells in vitro. Eventually, rescue assays implied that LINC00667 modulated NSCLC progression via EIF4A3-stabilized VEGFA. Yes Our study was the first to illustrate that LINC00667 was upregulated in NSCLC and LINC00667 silence refrained the proliferation, migration, and angiogenesis of NSCLC cells in vitro. 32281700 LINC00667 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miRNA-130a-3p/AR signal pathway) Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay We found that the expression of LINC00667 was upregulated in HCC tissues and cell lines. This inhibitory effect could be counteracted by miR-130a-3p inhibitor. LINC00667 reduced the inhibition of AR expression by miR-130a-3p, which correlated with the progression of HCC. Our finding suggests LINC00667 is a molecular sponge in the miR-130s-3p/AR signal pathway in the progression of HCC, in which it relieves the repressive function of miR-130a-3p on the AR expression. Upregulation of LINC00667 was significantly associated with the unfavorable prognosis of HCC in our study patients. Yes On the other hand, low expression of LINC00667 significantly inhibited the cell proliferation, cell migration and cell invasion of HCC in vitro and tumor growth in vivo. 34907204 LINC00667 LncRNA Homo sapiens Esophageal Neoplasms EC cells Interaction(miR-200b-3p/SLC2A3 Axis) Flow Cytometry//qRT-PCR//Western Blot In this work, we found that LINC00667 expression was up-regulated in EC cell lines, and LINC00667 knockdown inhibited cell proliferation, migration, and invasion in EC cells. In addition, it showed that LINC00667 functioned as competitive endogenous RNA for miR-200b-3p by the DIANA-LncBase database. Moreover, we used targetscan online software to predict SLC2A3 as a target gene of miR-200b-3p. Subsequently, rescue experiments confirmed that knocking out SLC2A3 could reverse the inhibitory effect of miR-200b-3p on EC cells transfected with sh-LINC00667. Yes In this work, we found that LINC00667 expression was up-regulated in EC cell lines, and LINC00667 knockdown inhibited cell proliferation, migration, and invasion in EC cells. 34313922 LINC00667 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cells regulation[YY1/LINC00667/miR-200c-3p/PDK1 axis ] qRT-PCR//Luciferase Report Assay//RIP//ChIP Our data indicated that LINC00667 was highly expressed in CCA tissues and cells, and transcription factor Yin Yang 1 (YY1) induced LINC00667 expression in CCA cells.Targeting the YY1/LINC00667/miR-200c-3p/PDK1 axis may provide a new therapeutic strategy for CCA treatment. Up-regulated LINC00667 was significantly associated with lymph node metastasis, advanced TNM stage, and poor prognosis. Yes Knockdown of LINC00667 suppressed the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of CCA cells, while overexpression of LINC00667 acquired opposite effects. 33040228 LINC00665 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissue Regulation[miR-149-3p/RNF2 axis] qRT-PCR//Luciferase Report Assay In the present study, we found that LINC00665 expression was significantly elevated in GC tissues and cell lines. High LINC00665 expression was associated with TNM stage, histological grade, and poor prognosis of GC patients. Yes Function assays showed that LINC00665 suppression significantly reduced GC cells viability and invasion ability in vitro. 31695413 LINC00665 LncRNA Homo sapiens Breast Neoplasms BCa tissues and cell lines regulation[triggering EMT] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay LINC00665 was highly expressed in BCa tissues and cell lines, and the high expression of LINC00665 could be used to predict a poor prognosis of BCa patients. In addition, LINC00665 may promote the malignant metastasis of BCa cells by affecting the EMT process. LINC00665 was highly expressed in BCa tissues and cell lines, and the high expression of LINC00665 could be used to predict a poor prognosis of BCa patients. Yes In addition, the results of in vitro cell experiments showed that the migration and invasion ability of BCa cells were remarkably attenuated after downregulation of LINC00665. 32271427 LINC00665 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC lung tissues and cells regulation[miR-138-5p/E2F3 signaling pathway] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay As a result, LINC00665 expression was upregulated in NSCLC lung tissues and cells. In conclusion, dysregulation of LINC00665 plays a vital role in NSCLC progression, indicating that its downregulation may confer decreased cell proliferation and invasion via the miR-138-5p/E2F3 signaling pathway. Yes Downregulated LINC00665 could arrest A549 and H1299 cell proliferation and invasion in vitro, and this finding was recapitulated in vivo. 32403047 LINC00665 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer cell lines Interaction(miR-181a-5p/FHDC) qRT-PCR//Luciferase Report Assay//Transwell Assay//Western Blot We found that LINC00665 was upregulated in ovarian cancer cell lines. LINC00665 downregulated the miR-181a-5p in SKOV-3 and OVCAR-3 cells. The knockdown of miR-181a-5p evidently reverses the inhibitory effect of sh-LINC00662. Besides, FH2 domain containing 1 (FHDC1) has been proved to deed as an effective target of miR-181a-5p. Yes Besides, a series of assays including flow cytometry, wound-healing, transwell, cell counting Kit-8 (CCK-8), and EdU assay confirmed that the knockdown of LINC00665 could reduce the viability, proliferation, and migration of SKOV-3 and OVCAR-3 cells. 35524876 LINC00665 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(miR-708 and miR-142-5p/RAP1B ) qRT-PCR//RIP//FISH In this study, we found that LINC00665 was highly expressed in OS tissues and cell lines, and its high expression was associated with malignant feature and poor prognosis of OS.Mechanistically, LINC00665 served as a sponge for miR-708 and miR-142-5p and positively mediated the expression of their target RAP1B. Finally, we confirmed that LINC00665 exercised its biological functions by mediating RAP1B. Yes In OS cells, LINC00665 could facilitate the proliferation, migration, and invasion to play an oncogenic role. 34306997 LINC00665 LncRNA Homo sapiens Osteosarcoma OS cells Interaction(LINC00665/miR-1249-5p/WNT2B/Wnt) qRT-PCR//Luciferase Report Assay LINC00665 was significantly up-regulated in OS cells. Mechanically, LINC00665 acted as a competing endogenous RNA (ceRNA) to sponge miR-1249-5p and thereby modulated Wnt family member 2B (WNT2B) to activate Wnt pathway. Wnt pathway activated LINC00665 expression transcriptionally. Yes LINC00665 silence facilitated OS cell proliferation, migration, invasion, and EMT while inhibiting cell apoptosis. 36387061 LINC00665 LncRNA Homo sapiens Uterine Cervical Neoplasms HeLa cells Activation(WNT-CTNNB1/β‑catenin signaling pathway) In Vivo Experiment//Western Blot//qRT-PCR//IF//RNA-seq//Cell Proliferation Assay//Transwell Assay The results showed that silencing LINC00665 reduced cell viability of Hela cells, up-regulated protein expression level of E-cadherin, down-regulated protein expression levels of N-cadherin, Vimentin and CTNNB1, and inhibited cell migration and invasion of HeLa cells. Bioinformatics analysis results showed that LINC00665 might promote EMT by activating WNT-CTNNB1/β‑catenin signaling pathway. Yes The results showed that silencing LINC00665 reduced cell viability of Hela cells, up-regulated protein expression level of E-cadherin, down-regulated protein expression levels of N-cadherin, Vimentin and CTNNB1, and inhibited cell migration and invasion of HeLa cells. 33903885 LINC00665 LncRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR‑34a‑5p/AGTR1) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Microarray//Cell Proliferation Assay//IHC//Invasion Assay High expression of LINC00665 was marked in glioma tissues and cells, which correlated with an unsatisfactory prognosis. LINC00665 acted as a competing endogenous RNA by sponging miR‑34a‑5p to upregulate angiotensin II receptor type 1 (AGTR1). LINC00665 promoted the progression of glioma by acting as a competitive endogenous RNA to competitively bind to miR‑34a‑5p and mediate AGTR1 expression. High expression of LINC00665 was marked in glioma tissues and cells, which correlated with an unsatisfactory prognosis. Yes Upregulation of LINC00665 significantly promoted the proliferation and invasion of glioma cells. 33650673 LINC00665 LncRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-129-5p/HMGB1 ) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay INC00665 expression was markedly increased in glioma. Mechanistically, LINC00665 could decoy miR-129-5p, and indirectly increased HMGB1 expression. High LINC00665 expression in glioma was closely linked to larger tumor diameter, higher pathologic grade, heterogeneous MRI signal of the tumor, increased peritumoral edema, and stronger MRI enhancement characteristics. Yes LINC00665 overexpression facilitated the malignant behavior of glioma cells, while LINC00665 knockdown played the reverse role. 35702084 LINC00665 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Regulation[ AKR1B10-ERK signaling] RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Herein, we reported the identification of a novel lncRNA, linc00665 (ENST00000590622), which was markedly upregulated in lung adenocarcinoma (LUAD) tissues and might serve as an independent predictor for poor prognosis.Mechanistically, transcription factor SP1 induced the transcription of linc00665 in LUAD cells, which exerted its oncogenic role by functioning as competing endogenous RNA (ceRNA) for miR-98 and subsequently activating downstream AKR1B10-ERK signaling pathway. Together, our study elucidates oncogenic roles of linc00665-miR98-AKR1B10 axis in LUAD tumorigenesis, which may serve as potential diagnostic biomarkers and therapeutic targets. Yes Functional assays indicated that linc00665 reinforced LUAD cell proliferation and metastasis in vitro and in vivo. 30692511 LINC00665 LncRNA Homo sapiens Adenocarcinoma of Lung Eighty-four cases of clinical human LUAD tissue samples and the adjacent paired normal lung tissues Interaction(miR-181c-5p/ZIC2 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The results showed that LINC00665, HOXA1, ZIC2, and HOXA11 levels were increased in LUAD tissues, while miR-181c-5p level was decreased when compared to the adjacent normal tissues. In summary, the present study reveals that silencing of LINC00665 suppresses LUAD progression through targeting miR-181c-5p/ZIC2 axis. High expression levels of LINC00665, ZIC2, HOXA1 and HOXA11, and low expression of miR-181c-5p were closely linked to poor prognosis of LUAD patients. Yes Knockdown of LINC00665 induced obvious inhibitions in cell viability, clone formation, invasion and tumorigenesis in LUAD cells, whereas miR-181c-5p downregulation significantly neutralized these effects. 34232917 LINC00665 LncRNA Homo sapiens Adenocarcinoma of Lung clinical samples and cell lines Interaction( miR-195-5p/MYCBP axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//FISH//Luciferase Report Assay//EdU Staining Based on pan-cancer screening analyses, we identified that the noncoding RNA LINC00665 was up-regulated in lung adenocarcinoma, which was subsequently confirmed in clinical samples and cell lines. The results of bioinformatics prediction and RNA pull-down assay indicated that LINC00665 directly interacted with miR-195-5p. This was also confirmed by fluorescence colocalization. Furthermore, luciferase reporter assay demonstrated that Myc binding protein (MYCBP, also called AMY-1), which enhanced c-Myc transcriptional activity, was the target gene of LINC00665 dependent on miR-195-5p. Higher expression of LINC00665 was positively associated with poor prognosis and advanced T stage. Yes Next, using gain- and loss- of function approaches, we revealed that LINC00665 promotes cell proliferation, cell migration, invasion, and suppresses cell apoptosis in LUAD through in vitro and in vivo experiments. 34277412 LINC00665 LncRNA Homo sapiens Prostatic Neoplasms PC samples regulation[ miR-1224-5p/SND1 Axis] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LINC00665 expression was increased in PC samples in contrast to control tissues, according to bioinformatics analysis and qRT-PCR validation. LINC00665 is a novel oncogenic gene in PC by targeting miR-1224-5p/SND1 pathway and may be a therapeutic target. LINC00665 high expression was related to a poor prognosis. Yes LINC00665 knockdown markedly attenuated growth and metastasis of PC cells and impaired tumor propagation in vivo. 32273723 LINC00659 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues regulation[promoting the expression of SUZ12] qRT-PCR//RNA Pull-Down//Luciferase Report Assay As a result, LINC00659 expression was increased in gastric cancer tissues, which was closely associated with tumour stage and lymph node metastasis, but was not correlated with age, gender and tissue differentiation. Additionally, LINC00659 could regulate cell cycle and invasion of gastric cancer by promoting the expression of SUZ12. As a result, LINC00659 expression was increased in gastric cancer tissues, which was closely associated with tumour stage and lymph node metastasis, but was not correlated with age, gender and tissue differentiation.Survival curve analysis showed that patients with low expression of LINC00659 harboured higher overall survival. Yes In vitro, the level of LINC00659 was increased in gastric cancer cells. Afterwards, the expression of LINC00659 was down-regulated in SGC-7901 and BGC-823 cells by plasmid-mediated si-LINC00659 transfection. Consequently, the cell invasion ability was weakened, the cell cycle was inhibited, and cell viability was also suppressed. 33145980 LINC00659 LncRNA Homo sapiens Stomach Neoplasms GC specimens and cells Interaction(miR-370/AQP3 Axis) RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay We firstly demonstrated that LINC00659 levels were distinctly up-regulated in both GC specimens and cells using bioinformatics analysis and RT-PCR. The results of ChIP assays and luciferase reporter assays confirmed that upregulation of LINC00659 was activated by SP1 in GC. Mechanistic investigation indicated that LINC00659 served as a competing endogenous RNA (ceRNA) for miR-370, thereby resulting in the upregulation of leading to the depression of its endogenous target gene AQP3. Clinical assays revealed that higher levels of LINC00659 were associated with TNM stage, lymphatic metastasis, and poorer prognosis. Yes Lost-of-function assays indicated that knockdown of LINC00659 suppressed the proliferation, metastasis, and EMT progress of GC cells in vitro. 35957833 LINC00525 LncRNA Homo sapiens spinal chordoma spinal chordoma tissues interaction[ targeted miR-31-5p and miR-125a-5p] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay After LINC00525 was downregulated in spinal chordoma cells, there were inhibitory effects on cell proliferation, migration, invasion and EMT but a promoting effect on cell apoptosis.All these results suggested that LINC00525 targeted miR-31-5p and miR-125a-5p to promote the tumorigenesis and progression of spinal chordoma. Yes Tumorigenesis of spinal chordoma in vivo was also inhibited by knockdown of LINC00525 via the promotion of miR-31-5p and miR-125a-5p. 33370717 LINC00623 LncRNA Homo sapiens Pancreatic Neoplasms PDAC cells Interaction(LINC00623/NAT10 signaling axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//RIP//RNA-seq//IP//IHC//IF A novel lncRNA, LINC00623, was identified, and its diagnostic value was confirmed, as it could discriminate patients with PDAC from patients with benign pancreatic neoplasms and healthy individuals. Mechanistically, LINC00623 bound to N-acetyltransferase 10 (NAT10) and blocked its ubiquitination-dependent degradation by recruiting the deubiquitinase USP39. As a key regulator of N4-acetylcytidine (ac4C) modification of mRNA, NAT10 was demonstrated to maintain the stability of oncogenic mRNAs and promote their translation efficiency through ac4C modification. Yes Moreover, LINC00623 was shown to promote the tumorigenicity and migratory capacity of PDAC cells in vitro and in vivo. 35978332 LINC00612 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines Interaction[sponging miR-590 to upregulate PHF14] RNA Pull-Down//Western Blot//qRT-PCR//FISH//Luciferase Report Assay LINC00612 was upregulated in BC tissues and cell lines.Our results indicate that LINC00612 enhances the proliferation and invasion ability of BC cells by sponging miR-590 to upregulate PHF14 expression and promote BC cellular EMT, suggesting that LINC00612 may act as a potential biomarker and therapeutic target for BC. Yes Functionally, downregulation of LINC00612 inhibited cell proliferation and invasion in vitro and in vivo, whereas overexpression of LINC00612 resulted in the opposite effects. 30940184 LINC00612 LncRNA Homo sapiens Osteosarcoma osteosarcoma cells interaction[miR-214-5p] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay LINC00612 was found to be significantly upregulated in osteosarcoma cells and metastatic osteosarcoma. Our study shows that LINC00612 plays an important role in regulating the proliferation and invasion of osteosarcoma by endogenously competing with miR-214-5p and mediating EMT. Yes LINC00612 overexpression promoted the proliferation, invasion and in vivo explant growth of osteosarcoma. 32311343 LINC00607 LncRNA Homo sapiens Osteosarcoma cell lines interaction[ miR-607,E2F6 ] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//CCK8//FISH//Luciferase Report Assay//Colony Formation Assay Based on the RNA-sequencing results, LINC00607 expression was significantly upregulated in pulmonary metastasis within OS. This work revealed that LINC00607 worked as an miR-607 sponge to upregulate E2F6 expression, which promoted tumor proliferation in OS. Yes Functional experiments revealed that LINC00607 promoted migration and invasion of endothelial cells to exacerbate epithelial-mesenchymal transition (EMT). Finally, we found that LINC00607 promoted OS progression in vivo. 33585204 LINC00607 LncRNA Homo sapiens Thyroid Neoplasms TC cell lines and tissues Interaction(CASP9) Western Blot//Flow Cytometry//FISH//RIP//qRT-PCR//Colony Formation Assay LINC00607 expression was up-regulated in the doxorubicin-resistant TC cell lines and tissues and negatively correlated to the poor prognosis of TC patients. Notably, it was also revealed that LINC00607 down-regulated the CASP9 expression by promoting CASP9 promoter methylation. LINC00607 expression was up-regulated in the doxorubicin-resistant TC cell lines and tissues and negatively correlated to the poor prognosis of TC patients. Yes Knockdown of LINC00607 suppressed doxorubicin resistance, proliferation and colony formation, and promoted cell apoptosis of TC cells in vitro, as well as suppressed tumour growth in vivo, whereas LINC00607 overexpression was observed to exercise the opposite effects. 34232553 LINC00589 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues Interaction(hnRNPA1/ PKM to PKM2) H&E Staining We revealed that LINC00589 was downregulated in GC tissues and suppressed the metastatic ability of GC cells. Mechanistically, LINC00589 exerted tumor suppressive function by promoting hnRNPA1 protein ubiquitination and proteasomal degradation, thus blocking alternative splicing of PKM to PKM2. Yes Furthermore, LINC00589 delivered by PMSNs could suppress the peritoneal metastasis of GC in vivo and in vitro. 36126899 LINC00589 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines Regulation[miR-214-3p/FOXP2 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay TSLNC8 is significantly increased in breast cancer tissues and cell lines. Further analysis indicated that TSLNC8 could directly bind to miR-214-3p. Up-regulation of miR-214-3p may attenuate the suppressive role of TSLNC8 on the proliferation capacity of breast cancer cells. Moreover, miR-214-3p was found to directly interact with the 3'-untranslated region (UTR) of Forkhead box P2 (FOXP2) in luciferase assays, suggesting that FOXP2 may be one of the downstream targets of miR-412-3p. Yes TSLNC8 is significantly increased in breast cancer tissues and cell lines. 31646574 LINC00589 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines Regulation[IL-6/STAT3/HIF-1alpha signaling pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//IF//Transwell Assay The results revealed that TSLNC8 was significantly downregulated in lung cancer cells compared to normal bronchial epithelial cells.lncRNA TSLNC8 remarkably inhibited the proliferation and migration and accelerated apoptosis of lung cancer cells by targeting the IL-6/STAT3/HIF-1alpha signaling pathway. TSLNC8 may be a potential therapeutic target for the diagnosis and treatment of NSCLC. Yes Further experiments showed that overexpression of TSLNC8 in A549 cells significantly inhibited proliferation in a time-dependent manner and promoted cell apoptosis. We found that TSLNC8 overexpression suppressed cell migration and invasion 31601776 LINC00589 LncRNA Homo sapiens Glioma glioma tissues,cells Expression[lower expressed] qRT-PCR//Wound Healing Assay//MTT//Transwell Assay It was initially reported that the relative transcript levels of TSLNC8 were significantly decreased in human glioma tissues and cultured glioma cells, as evidenced by RT?qPCR. Among clinical variables, the expression of TSLNC8 was negatively associated with tumor size, distant metastasis, and tumor, node and metastasis stage. Yes Furthermore, cell apoptotic rate was upregulated in TSLNC8 plasmid?treated U251 and SWO38 cells, and inhibited by siRNA against TSLNC8 in SHG?44 and BT325 cells by cell apoptotic assay. 30387847 LINC00589 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines regulation[CTNNB1,HuR] RNA Pull-Down//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our results showed a significant increase of TSLNC8 expression in PC tissues and cell lines.Taken together, our present study revealed that oncogenic lncRNA TSLNC8 positively regulate PC growth and metastasis via HuR-mediated mRNA stability of CTNNB1, extending the understanding of PC pathogenesis regulated by lncRNAs. Upregulation of TSLNC8 expression in PC tissues was closely correlated with TNM stage, distant and lymph node metastasis, and poor prognosis of PC patients. Yes Functional experiments demonstrated that TSLNC8 promoted PC cells proliferation and invasion in vitro, and enhanced PC growth and metastasis in vivo. 32951177 LINC00588 LncRNA Homo sapiens Osteosarcoma regulation[LINC00588/miRNA-1072/TP53 axis] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay Using information from GEO Datasets, we found that the lncRNA LINC00588 was downregulated in osteosarcoma (OS) in bone but was upregulated in the metastatic tumor present in the lung. Hence, we believe that the LINC00588/miRNA-1072/TP53 axis could potentially serve as a therapeutic target or diagnostic biomarker for osteosarcoma. Yes Overexpression of LINC00588 appeared to inhibit cell proliferation, viability, migration, invasion, endothelial cell function, EMT, and tumor growth but not apoptosis, while we got the opposite result when we knocked down LINC00588. 32265694 LINC00578 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and serums Expression[highly expressed] qRT-PCR//MTT The results showed that LINC00346, LINC00578, and LINC00673 were highly expressed, whereas LINC00671, LINC00261, and SNHG9 were lowly expressed in PC tissues and serums, and their expression levels were correlated with clinical stages. Survival analysis indicated that patients with high expression of LINC00346, LINC00578, or LINC00673 had significantly lower survival rate, while patients with high expression of LINC00671, LINC00261, and SNHG10 had significantly higher survival rate. Yes In addition, we also found that silence of LINC00346, LINC00578 and LINC00673 inhibited PC cell proliferation, and silence of LINC00671, LINC00261, and SNHG10 promoted PC cell proliferation. 30210701 LINC00551 LncRNA Homo sapiens Esophageal Neoplasms ESCC tissues regulation[HSP27 phosphorylation] qRT-PCR Three paired ESCC and normal tissues were subjected to next-generation sequencing and we identified 82 upregulated and 60 downregulated lncRNAs, including LINC00551, which was confirmed to markedly downregulated in 78 ESCC tissues and in the Gene Expression Profiling Interactive Analysis data set. RNA pull-down and mass spectrometry assays identified the potential LINC00551 binding proteins, and HSP27 was a promising LINC00551 targeting proteins after RNA immunoprecipitation assay. At the protein level, LINC00551 bound to and decreased HSP27 phosphorylation, and in turn, downregulated ESCC cell proliferation and invasion. Downregulated LINC00551 expression was associated with lymph node metastasis, advanced TNM stage, and tumor size. Moreover, downregulated LINC00551 expression was also associated with poor progression-free survival and overall survival of ESCC patients. Yes In vitro and in vivo, LINC00551 overexpression inhibited ESCC cell proliferation and invasion, whereas knockdown of LINC00551 expression promoted ESCC cell proliferation and invasion. 32677057 LINC00536 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Regulation[Wnt3a/β-Catenin signaling] Western Blot//CCK8//qRT-PCR//IHC//EdU Staining//Transwell Assay In the present study, we found LINC00536 expression was highly expressed in BC tissues compared with controls and negatively associated with survival rate in BC patients. In summary, our findings demonstrated that LINC00536 promoted BC progression by modulating the Wnt3a/β-Catenin signaling. In the present study, we found LINC00536 expression was highly expressed in BC tissues compared with controls and negatively associated with survival rate in BC patients. Yes Gain-of-function assays indicated that LINC00536 overexpression promoted the proliferation, migration and invasion, whereas LINC00536 knockdown attenuated the cell phenotypes above in BC cell lines. In vivo assay illustrated that LINC00536 knockdown inhibited BC growth in vivo. 30851243 LINC00526 LncRNA Homo sapiens Glioma glioma tissues Interaction[AXL] RNA Pull-Down//ChIP//Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay In this study, we identified a novel lncRNA LINC00526, which is significantly low expressed in glioma. Low expression of LINC00526 is correlated with aggravation and poor survival in glioma.Mechanistically, we found that LINC00526 directly interacts with EZH2, represses the binding of EZH2 to AXL promoter, attenuates the transcriptional activating roles of EZH2 on AXL, and therefore represses AXL expression. Via repressing AXL, LINC00526 further represses PI3K/Akt/NF-κB signalling. Intriguingly, we identified that NFKB1 and NFKB2 directly binds LINC00526 promoter and represses LINC00526 transcription. We further found that via activating NF-κB signalling, AXL represses LINC00526 transcription. Therefore, LINC00526/EZH2/AXL/PI3K/Akt/NF-κB form a feedback loop in glioma. In this study, we identified a novel lncRNA LINC00526, which is significantly low expressed in glioma. Low expression of LINC00526 is correlated with aggravation and poor survival in glioma. Yes Functional assays revealed that ectopic expression of LINC00526 inhibits glioma cell proliferation, migration, and invasion. LINC00526 silencing promotes glioma cell proliferation, migration and invasion. 31240814 LINC00526 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-5581-3p/BEX1) In Vivo Experiment//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay LINC00526 was found to be decreased in glioma tissues and cell lines compared with their normal counterparts. Mechanism analyses showed LINC00526 functions as a sponge for microRNA-5581-3p (miR-5581-3p) to regulate brain-expressed X-linked 1 (BEX1) expression and, in the end, affects glioma progression. Collectively, our study indicated LINC00526 serves as a tumor-suppressive lncRNA and directly regulates miR-5581-3p/BEX1 axis in glioma. Yes Silencing the expression of LINC00526 promotes, while forcing its expression, inhibits glioma cell growth and invasion. 33613672 LINC00525 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cells Interaction(miR-338-3p / UBE2Q1 / β-catenin axis) qRT-PCR//FISH//Western Blot It was found that LINC00525 was up-regulated, and promoted cell proliferation in colorectal cancer in vitro and in vivo. In colorectal cancer cells, hypoxia increasedLINC00525 expression, whereas knocking down LINC00525 reduced hypoxia-enhanced glycolysis. For specific molecular mechanisms, it was found that LINC00525 promoted UBE2Q1 expression by binding miR-338-3p, and UBE2Q1-stabilized β-catenin enhances hypoxia-enhanced glycolysis by activating HIF-1α. Yes It was found that LINC00525 was up-regulated, and promoted cell proliferation in colorectal cancer in vitro and in vivo. 35156520 LINC00619 LncRNA Homo sapiens Osteosarcoma Osteosarcoma tissues Regulation(HGF-mediated PI3K-Akt signalling pathway) qRT-PCR//Transwell Assay Osteosarcoma tissues presented with elevated positive expression rate of HGF, up-regulated expression levels of PCNA, HGF, PI3K, Akt, Bcl-2, ALP and OPN, and down-regulated expressions of Bax and LINC00619.HGF was verified as a target gene of lncRNA LINC00619. LINC00619 was found to down-regulate the expressions of PCNA, HGF, PI3K, Akt, Bcl-2, ALP, and OPN in osteosarcoma cells. Yes Up-regulation of lncRNA LINC00619 decreased cell growth, migration intensity, and invasion ability, but enhanced the apoptosis rate of osteosarcoma cells. 33797312 LINC00624 LncRNA Homo sapiens Liver Neoplasms cell lines Regulation(HDAC6-TRIM28-ZNF354C) Bioinformatics Analysis Mechanistically, higher levels of LINC00624 strengthen the interaction between histone deacetylase 6 (HDAC6) and tripartite motif containing 28 (TRIM28), which accelerates HDAC6 ubiquitination and degradation. Moreover, LINC00624 binds to the RBCC domain of TRIM28, inhibits trimer formation, and weakens the interaction between TRIM28 and zinc finger protein 354C (ZNF354C). Yes Overexpression of LINC00624 enhances tumor growth and metastasis in vitro and in vivo. 32869873 LINC00659 LncRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(miR-342-3p/ANXA2 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of LINC00659 in CAF-derived exosomes was significantly increased, and fibroblasts could transfer exosomal LINC00659 to CRC cells. Mechanistically, LINC00659 interacts directly with miR-342-3p to increase ANXA2 expression in CRC cells. Yes We further revealed that transfection of miR-342-3p mimic or sh-ANXA2 could obviously reverse the promotion effect of exosomal LINC00659 on CRC progression. Functional studies reveal that LINC00659 is transferred from CAFs to the cancer cells via exosomes, where it promotes CRC cell proliferation, invasion, migration and EMT progression in vitro. 33407563 LINC00628 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Regulation[PI3K/Akt signaling pathway] Flow Cytometry//qRT-PCR//Western Blot LINC00628 expression was significantly decreased in osteosarcoma tissues compared with adjacent tissues. LINC00628 expression was decreased in osteosarcoma. The overexpression of LINC00628 inhibited the proliferation, invasion and migration and promoted cell apoptosis in osteosarcoma cells through the inactivation of PI3K/Akt signaling pathway. Meanwhile, osteosarcoma tissues with metastasis were significantly associated with a low expression level of LINC00628 and the low expression level of LINC00628 has a lower overall survival rate. Yes LINC00628 expression was increased in osteosarcoma cell lines after transfection with lncRNA-LINC00628 and the cell proliferation, invasion and migration in osteosarcoma cells after transfection with lncRNA-LINC00628 were significantly inhibited. 30280767 LINC00657 LncRNA Mus musculus Chronic Constriction Injury spinal cord tissues Regulation[miR-136/ZEB1 axis] qRT-PCR//Luciferase Report Assay//Western Blot A chronic constriction injury (CCI) rat model was established, and we found that LINC00657 was greatly increased in CCI rats associated with a decrease of miR-136. In conclusion, it was implied that LINC00657 can induce the neuropathic pain development via regulating miR-136/ZEB1 axis. Yes Inhibition of LINC00657 suppressed neuropathic pain via alleviating mechanical and thermal hyperalgesia. 30203524 LINC00649 LncRNA Homo sapiens Stomach Neoplasms 54 paired cancerous and non-cancerous tissues Interaction(miR-16-5p/YES-associated protein 1 (YAP1)/Hippo pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay we found that LINC00649 tended to be enriched in cancerous tissues and cells but not in their normal counterparts,Finally, we proved that LINC00649 exerted its tumor-promoting effects in GC by regulating the miR-16-5p/YES-associated protein 1 (YAP1)/Hippo pathway. Yes Next, by performing the gain- and loss-of-function experiments, we expectedly found that LINC00649 acted as an oncogene to accelerate GC cell proliferation, migration and epithelial-mesenchymal transition (EMT) in vitro and promote its tumorigenesis in vivo 33975517 LINC00649 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC clinical samples and cells Interaction(NF90/NF45 complex) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay LINC00649 increased hypoxia-inducible factor 1α (HIF-1α) mRNA stability and protein expression by interacting with the nuclear factor 90 (NF90)/NF45 complex. We demonstrated that LINC00649 interacts with the NF90/NF45 complex to increase the mRNA stability of HIF-1α and up-regulate HIF-1α expression, thereby inducing the proliferation, invasion, and migration of TNBC cells as well as tumor growth and metastasis. LINC00649 was found to be a key molecule involved in the occurrence and development of TNBC by screening of public databases and detection of TNBC clinical samples. Yes In vitro, interference with LINC00649 inhibits MDA-MB-231 and BT549 cell proliferation, migration, and invasion, and the addition of HIF-1α revised this effect. In vivo experiments showed that LINC00649 promoted the growth and metastasis of TNBC. 35188449 LINC00649 LncRNA Homo sapiens lung squamous cell carcinoma LUSC cells Interaction(E2F7/LINC00649/TAF15/MAPK6/MAPK signaling pathway) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay As a result, LINC00649 was discovered to be with high expression in LUSC cells. Results of mechanism assays validated that E2F transcription factor 7 (E2F7) was a transcription activator of LINC00649 and induced its up-regulation in LUSC cells. Furthermore, LINC00649 recruited TAF15, which is TATA-box binding protein associated factor 15 to stabilize mitogen-activated protein kinase 6 (MAPK6) expression and activate the transcription of MAPK6, thereby enhancing MAPK6 expression to activate the MAPK signaling pathway. In summary, our research determined the E2F7/LINC00649/TAF15/MAPK6/MAPK signaling pathway in regulating LUSC development, which made LINC00649 a potential biomarker for LUSC treatment. Yes Moreover, it was confirmed through functional assays that the knockdown of LINC00649 hindered the occurrence and progression of LUSC. 35228660 LINC00645 LncRNA Homo sapiens Glioma GBM tissues and cell lines Regulation[linc00645/miR-205-3p/ZEB1 signaling axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay//IF In the present study, linc00645 expression was significantly upregulated in GBM tissues and cell lines. Furthermore, linc00645 directly interacted with miR-205-3p and upregulated of miR-205-3p impeded efficiently the increase of ZEB1 induced by linc00645 overexpression. Moreover, knockdown of linc00645 significantly suppressed the progression of glioma cells in vivo. miR-205-3p was a target of linc00645 and linc00645 modulates TGF-β-induced glioma cell migration and invasion via miR-205-3p. Taken together, our findings identified the linc00645/miR-205-3p/ZEB1 signaling axis as a key player in EMT of glioma cells triggered by TGF-β. These data elucidated that linc00645 plays an oncogenic role in glioma and it may serve as a prognostic biomarker and a potential therapeutic target for the treatment of glioma in humans. High level of linc00645 was associated with poor overall survival in GBM patients. Yes Knockdown of linc00645 suppressed the proliferation, stemness, migration, invasion, and reversed transforming growth factor (TGF)-β-induced motility of glioma cell lines. 31558707 LINC00641 LncRNA Homo sapiens Breast Neoplasms BC tissues Interaction[sponging miR-194-5p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay This study shows that LINC00641 expression level was decreased in BC tissues. In conclusion, LINC00641 inhibits BC cell proliferation, migration, as well as invasion by sponging miR-194-5p. LINC00641 expression level was negatively related to tumor size, lymph-node metastasis, as well as clinical stage. Yes LINC00641 overexpression inhibited cell proliferation, migration, and invasion but stimulated apoptosis in BC cells. LINC00641 overexpression also remarkably reduced BC growth and metastasis in vivo. 31490021 LINC00641 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines Interaction[sponging miR-424-5p to upregulate PLSCR4] qRT-PCR At first, downregulation of LINC00641 was identified in NSCLC cells. Through mechanism investigation, we determined that LINC00641 acted as a competing endogenous RNA (ceRNA) in NSCLC by sponging miR-424-5p to upregulate phospholipid scramblase (PLSCR4) expression. Further rescue assays indicated that miR-424-5p and PLSCR4 could reverse LINC00641-mediated cellular processes. Taken together, it is demonstrated in our study that LINC00641 can function as a tumor suppressor in NSCLC via a ceRNA network. Yes Functionally, LINC00641 suppressed cell proliferation and induced cell apoptosis in NSCLC, indicating that LINC00641 exerted tumor-suppressive role in NSCLC. 31322545 LINC00641 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines Interaction(microRNA-340-5p) Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Colony Formation Assay//Transwell Assay The expression of LINC00641 was overexpressed in RCC tissues and cell lines, and high LINC00641 expression was correlated with tumor-node-metastasis stage. Mechanistically, miR-340-5p was validated to be targeted by LINC00641 and knockdown of miR-340-5p counteracted LINC00641 silencing-mediated inhibition of RCC progression. The expression of LINC00641 was overexpressed in RCC tissues and cell lines, and high LINC00641 expression was correlated with tumor-node-metastasis stage. Yes Furthermore, Silencing of LINC00641 remarkably inhibited the ability of cell proliferation, colony formation, and invasive capacities, as well as increasing the apoptotic rates of RCC cells in vitro. 33853611 LINC00641 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-320d/MCL1 ) qRT-PCR//Tunel The data displayed, LINC00641 was prominently elevated in OS tissues and cells, especially in DDP-resistant tumors and cell lines. On the grounds of bioinformatics prediction, a direct binding of LINC00641 with miR-320d existed, whose target was MCL1. Meanwhile, LINC00641 modulated MCL1 via targeting miR-320d. Additionally, repressive LINC00641 blocked MCL1 via emulative interaction with miR-320d, thus expediting DDP-sensitivity of OS cells. Yes Knock-down LINC00641 was able to attenuate progression of DDP-resistant OS cells thus dampening their drug resistance toward DDP. Moreover, knock-downing LINC00641 gene was also able to manifest antagonism toward DDP-resistance in vivo. 35266447 LINC00641 LncRNA Homo sapiens Leukemia, Myeloid, Acute blood,cell lines Regulation[miR-378a/ZBTB20 axis] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay We found that LINC00641 was highly expressed in AML specimens and cell lines. The results using bioinformatics assays predicted the complementary binding sites within LINC00641 and miR-378a, which was demonstrated by the use of the Luciferase reporter assays. In addition, we also demonstrated that ZBTB20 was a direct target of miR-378a. Moreover, the inhibition of miR-378a could rescue the ZBTB20 protein level decrease induced by LINC00641 knockdown. Yes Functionally, the silence of LINC00641 inhibited the proliferation, migration, invasion, and cell cycle arrest in AML cells while inducing their apoptosis. 31539138 LINC00641 LncRNA Homo sapiens Prostatic Neoplasms 23 paired PCa tumor tissues and adjacent tissues Interaction(miR-365a-3p/VGLL4 axis) RNA Pull-Down//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay We found LINC00641 and VGLL4 was reduced, while miR-365a-3p was elevated expression in PCa tissues compared with normal tissues. Functional assays revealed that miR-365a-3p/VGLL4 pair was the downstream targets of LINC00641. Yes LINC00641 overexpression inhibited growth and invasion abilities of PCa cells in vitro. 33506898 LINC00638 LncRNA Homo sapiens Arthritis, Rheumatoid PBMCs Expression(lower expressed) CCK8//Transfection Compared with the healthy control subjects, RA patients had significantly increased ESR, CRP, RF, anti-CCP, IgA, and C4 levels (P < 0.05) and significantly decreased Linc00638 expression in the PBMCs (P < 0.01). The area under the receiver-operating characteristic (ROC) curve of Linc00638 was 91.86% with the best cut-off value of 0.74 for diagnosis of RA. Spearman correlation analysis showed that Linc00638 expression level was negatively correlated with age, course of disease, DAS28, ESR, CRP, RF and anti-CCP, and positively correlated with IL-4 and SOD levels (P < 0.05). Yes In RA-FLS, overexpression of Linc00638 significantly inhibited while Linc00638 interference obviously enhanced the cell viability. Over-expression of Linc00638 also significantly increased the levels of IL-4 and SOD (P < 0.05) and decreased the expressions of IL-6 and ROS (P < 0.05), while interference of Linc00638 produced the opposite effects in the cells (P < 0.05). 34308844 LINC00638 LncRNA Homo sapiens Arthritis, Rheumatoid 48 RA patients Expression(lower expressed) qRT-PCR//ELISA//IF Compared with the control group, the expression of LINC00638 in the RA group was lower (P<0.01). Yes Compared with siRNA-control group, LINC00638, IL-10, SOD2 and HO-1 in the siRNA-LINC00638 group were significantly decreased (all P<0.01), and TNF-α was significantly increased (P<0.01). 35545408 LINC00638 LncRNA Homo sapiens Arthritis, Rheumatoid PBMCs, RA-FLS Regulation(Nrf2/HO-1 pathway) Western Blot//CCK8//qRT-PCR//Flow Cytometry//IF//ELISA//Transwell Assay LINC00638 expression was found to be significantly decreased in PBMCs of RA patients, and it was negatively correlated with erythrocyte sedimentation rate, interleukin (IL)-17, reactive oxygen species (ROS), and disease activity scores for 28 joints (DAS28). Overexpression of LINC00638 activated the Nrf2/HO-1 pathway, markedly decreased the expressions of IL-6, IL-17, IL-23, ROS, as well as malondialdehyde, increased the total antioxidant capacity, and attenuated the proliferation and migration of RA-FLS, while silencing of LINC00638 reversed these manifestations. Yes Overexpression of LINC00638 activated the Nrf2/HO-1 pathway, markedly decreased the expressions of IL-6, IL-17, IL-23, ROS, as well as malondialdehyde, increased the total antioxidant capacity, and attenuated the proliferation and migration of RA-FLS, while silencing of LINC00638 reversed these manifestations. 35759235 LINC00632 LncRNA Homo sapiens Lung Neoplasms NSCLC tissues regulation[downregulating miR-1203] qRT-PCR//Luciferase Report Assay LINC00632 was lowly expressed in NSCLC tissues. LINC00632 is downregulated in NSCLC samples, which is closely linked to metastasis and prognosis in NSCLC patients. It inhibits the malignant development of NSCLC by negatively regulating miR-1203 level. Low level of LINC00632 indicated high rates of lymph node metastasis and distant metastasis, as well as poor prognosis in NSCLC. Yes Overexpression of LINC00632 suppressed in vitro proliferative and migratory abilities in NSCLC. Moreover, overexpression of LINC00632 inhibited tumor growth in nude mice bearing NSCLC. 32862599 LINC00632 LncRNA Homo sapiens Glioma gliomas tissues Interaction(ALDOA) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Co-IP//Flow Cytometry//FISH//qRT-PCR//RIP//IF//Cell Proliferation Assay//Transwell Assay In this study, we reported that ARST was downregulated in the gliomas. We further demonstrated that the tumor suppressive effects of ARST could be mediated by a direct binding to a glycolytic enzyme aldolase A (ALDOA), which together with cofilin, keeping the polymerization and depolymerization of actin filaments in an orderly dynamic equilibrium. Yes Overexpression of ARST in the glioma cells significantly suppressed various cellular vital abilities such as cell growth, proliferation, migration and invasion. The tumorigenic capacity of these cells in vivo was reduced as well. 34099027 LINC00630 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cultured cells Interaction(miR-199a/FGF7 axis) Western Blot//Migration Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay In the present study, lncRNA long intergenic non-protein coding RNA 630 (LINC00630) was found to be significantly upregulated in CCA tissues and cultured cells. Further investigations found that LINC00630 could interact with microRNA (miR)-199a, which specifically targeted fibroblast growth factor 7 (FGF7) for degradation. FGF7 overexpression restored the sh-LINC00630 transfection-induced decrease in CCA cell proliferation, migration and invasion. LINC00630 expression was positively associated with histological differentiation, TNM stage and lymph node invasion. Yes Short hairpin RNA (sh)-LINC00630 transfection could effectively decrease CCA cell proliferation, migration and invasion. 35154463 LINC00630 LncRNA Homo sapiens colon carcinoma colon carcinoma tissues and cell lines Interaction(miR-409-3p/HK2 axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay In this study, we found that the expression of LINC00630 was remarkably upregulated in colon carcinoma tissues and cell lines compared with that in adjacent tissues and the NCM-460 cell lines. In addition, we confirmed the direct interaction between LINC00630 and miR-409-3p in colon carcinoma cells using bioinformatics methods and dual luciferase reporter gene assay. Finally, we demonstrated that LINC00630 could promote cell growth and glycolysis and inhibit apoptosis by functioning as a miR-409-3p sponge, and further regulate hexokinase 2 (HK2) in colon carcinoma cells. Yes Knocking out LINC00630 resulted in inhibition of proliferation and glycolysis but increase in apoptosis. 35273690 LINC00629 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[binding to miR-196b-5p] qRT-PCR In gastric cancer, expression of LINC00629 and AQP4 was downregulated, and expression of miR-196b-5p was upregulated.LINC00629 competitively bound to miR-196b-5p, while AQP4 was a target of miR-196b-5p. Either downregulating miR-196b-5p or upregulating AQP4 could restrain the development of gastric cancer in vitro. LINC00629 overexpression repressed the growth of transplanted tumors in vivo. Taken together, LINC00629 competitively bound to miR-196b-5p to upregulate AQP4 expression, thereby inhibiting gastric cancer progression. Therefore, understanding of this mechanism may help to improve gastric cancer treatment. Yes Proliferation, invasion, and migration of gastric cancer cells were reduced after overexpression of LINC00629. 31674022 LINC00668 LncRNA Homo sapiens lung squamous cell carcinoma LUSC patients, LUSC cell lines Expression(highly expressed) qRT-PCR LINC00668 expression was significantly up-regulated in LUSC patients and high expression level of LINC00668 was associated with advanced tumor-node-metastasis (TMN) stage. LINC00668 expression was significantly up-regulated in LUSC patients and high expression level of LINC00668 was associated with advanced tumor-node-metastasis (TMN) stage. Moreover, the expression of LINC00668 significantly increased in smoking patients, and was a prognostic indicator for overall survival (OS) of smoking patients with LUSC. Yes In vitro experiments showed that LINC00668 has significantly higher expression level in LUSC cell lines and tissues compared to normal bronchial epithelial cell and para-tumor tissues; meanwhile, functional assay indicated knockdown of LINC00668 effectively inhibited the migration and invasion of LUSC cells. 35477186 LINC00668 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and HCC tissues regulation[miR-532-5p/YY1 axis] qRT-PCR//Western Blot//Transwell Assay LINC00668 was significantly up-regulated in HCC tissues and cell lines. Mechanistically, LINC00668 positively modulates the expression of YY1 by competitively binding to miR-532-5p. Yes LINC00668 knockdown inhibited cell proliferative, migratory and invasion abilities and slowed down the epithelial-mesenchymal transition (EMT) process. 32249890 LINC00668 LncRNA Homo sapiens Colorectal Neoplasms cell lines Interaction[sponging miR-188-5p and regulating USP47] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//EdU Staining//Transwell Assay LINC00668 was significantly upregulated in CRC tissues and cells.Conclusively, our findings demonstrated that lncRNA LINC00668 acted as an oncogenic role in CRC cells by sponging miR-188-5p and upregulating USP47 and may represent a potential marker for CRC patients. Yes Knockdown of LINC00668 suppressed cell proliferation and migration potential and induced cell apoptosis, but inhibition of miR-188-5p which was predicted to bind with LINC00668 reversed these effects. 31233752 LINC00887 LncRNA Homo sapiens lung carcinoma lung carcinoma tissues and cells Interaction(microRNA-206/NRP1 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay The expression levels of LINC00887 were upregulated in lung carcinoma tissues and cells compared with adjacent tissues or normal cells (BEAS-2B).Furthermore, LINC00887 was identified as a competing endogenous RNA and to directly interact with miR-206. Mechanistically, miR-206 was demonstrated to regulate neuropilin-1 (NRP1) expression by targeting the NRP1 3'-untranslated region. Yes Knockdown LINC00887 significantly inhibited the proliferation, migration and invasion of lung carcinoma A549 and NCI-H460 cells. 33376520 LINC00885 LncRNA Homo sapiens Breast Neoplasms cell lines Expression[highly expressed] qRT-PCR//RNA Pull-Down//Western Blot Long intergenic non-protein coding RNA 885 (LINC00885) was identified as significantly upregulated in breast ductal carcinoma in situ (DCIS). Yes We determined that LINC00885 induces premalignant phenotypic changes by increasing cell proliferation, motility, migration and altering 3D growth in normal and DCIS breast cell lines. 33049922 LINC00882 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR LncRNA 882 (LINC00882) is one of the lncRNAs that was significantly upregulated in HCC tissues compared with normal liver tissues. We found that upregulation of LINC00882 is correlated with poorer prognosis of HCC patients. Yes In vitro cell experiments demonstrated that knockdown of LINC00882 inhibits proliferation, migration and invasion of HCC cell lines. 30271163 LINC00882 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and clinical specimens Interaction(miR-214-3p/CENPM) Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay LINC00882 was markedly upregulated in HCC cells and clinical specimens. . Mechanistically, LINC00882 adsorbed miR-214-3p, thus promoting the expressions of CENPM. Rescue assays demonstrated that functions of LINC00882 deficiency in HCC cells were reversed through suppressing miR-214-3p. Yes Additionally, ATF2 could bind directly to the LINC00882 promoter region and activate its transcription. Loss-of-function studies further demonstrated that LINC00882 knockdown inhibited proliferation, invasion, and migration of HCC cells. 34513693 LINC00861 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines regulation[PTEN/AKT/mTOR signaling pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The results of the present study discovered that LINC00861 expression levels were significantly downregulated in cervical cancer tissues and CaSki and ME?180 cell lines. In conclusion, the findings of the present study indicated that the LINC00861/miR‑513b‑5p axis may inhibit the progression of cervical cancer cells through the PTEN/AKT/mTOR signaling pathway to suppress the EMT process. Downregulated LINC00861 expression levels were identified to be associated with an advanced?stage, lymph node metastasis and the poor survival of patients with cervical cancer. Yes The overexpression of LINC00861 reduced cervical cancer cell proliferation, migration, invasion and epithelial?mesenchymal transition (EMT) processes, upregulated PTEN protein expression levels and downregulated phosphorylated (p)?AKT and p?mTOR protein expression levels. 33179755 LINC00858 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR The results showed that LINC00858 had a high level of expressions in GC tissues as demonstrated by both online data and qRT-PCR assay. Yes Also, the knockdown of LINC00858 reduced the proliferation and migration of BGC823 and MGC803 cells in vitro. 33112114 LINC00858 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-363-3p/FOXP4 axis] CCK8//qRT-PCR//Transwell Assay Our findings revealed that LINC00858 expression was markedly upregulated in GC tissues and cell lines. Collectively, LINC00858 acted as an oncogene in GC via regulating miR-363-3p/FOXP4 axis, which indicated that LINC00858 might be a novel therapeutic target for the treatment of GC. Yes Loss-of-function experiments demonstrated that LINC00858 silencing inhibited the proliferation, migration and invasion of GC cells. 33015780 LINC00858 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation[miR-22-3p/YWHAZ axis ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay//Transwell Assay In this study, we firstly found that LINC00858 expression was significantly up-regulated in both CRC tissues and cell lines by both online data and RT-PCR assay. Mechanistically, bioinformatics analysis, dual-luciferase reporter assays, and western blot assays showed that LINC00858 functioned as competing endogenous RNA to repress miR-22-3p, which controlled its down-stream target YWHAZ. Then, we suggested that LINC00858 exerted its function through the miR-22-3p/YWHAZ axis. Then, clinical assay revealed that high LINC00858 expression was significantly associated with advanced clinical progression and poor prognosis. Multivariate analysis demonstrated that high LINC00858 expression was an independent poor prognostic factor for CRC patients. Yes Moreover, lost-of-function assay indicated that knockdown of LINC00858 suppressed CRC cells proliferation, migration and invasion, and promoted apoptosis. 30931636 LINC00858 LncRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues regulation[microRNA-25-3p/SMAD7 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay The present study aimed to reveal the role and possible molecular mechanisms of a new LNCRNA, LINC00858, in CRC. LINC00858 was increased in CRC tumor tissues, and patients with high LINC00858 expression had a shorter survival time. The present study aimed to reveal the role and possible molecular mechanisms of a new LNCRNA, LINC00858, in CRC. LINC00858 was increased in CRC tumor tissues, and patients with high LINC00858 expression had a shorter survival time. Yes Knockdown of LINC00858 expression suppressed cell proliferation and induced G0/G1 cell cycle arrest and apoptosis in TP53?wild?type CRC cells. 32323793 LINC00858 LncRNA Homo sapiens Colorectal Neoplasms CRC patients interaction[miR-4766-5p,PAK2] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//BrdU//Transwell Assay With a predicted poor prognosis, LINC00858 was upregulated in CRC patients. LINC00858 promoted CRC progression by sponging miR-4766 to upregulate PAK2, shedding lights on LINC00858 as a potential therapeutic target candidate in CRC treatment from bench to clinic. Yes LINC00858 knockdown suppressed cell proliferation, invasion, and migration abilities, meanwhile induced cell apoptosis. 31902050 LINC00858 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues,cell lines Interaction[ upregulating HNF4α and downregulating WNK2] RNA Pull-Down//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay We found that LINC00858 was highly expressed in primary colon cancer tissues and colon cancer cell lines, and was mainly located in the nucleus. In addition, we found that LINC00858 can bind to and upregulate the nuclear transcription factor HNF4α, leading to WNK2 expression downregulation. This, in turn, resulted in the promotion of colon cancer cell growth. High LINC00858 expression was found to correlate with a poor differentiation, advanced TNM stages and lymph node metastasis. Yes Exogenous overexpression of LINC00858 promoted cell proliferation, invasion and migration of colon cancer cells, and facilitated angiogenesis and tumor growth. 31884577 LINC00858 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues and cell regulation[WNK2] qRT-PCR//RNA Pull-Down//RIP//FISH There was high expression of LINC00858 and low expression of WNK2 in colon cancer tissues and cell lines. In summary, LINC00858 acts as a tumor-promoting lncRNA in colon cancer by downregulating WNK2. Yes Silencing of LINC00858 promoted apoptosis, senescence, and autophagy in colon cancer cells. 32768499 LINC00858 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-153-3p/Rabl3 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our results showed that LINC00858 was highly expressed in both HCC tissues and cell lines. In summary, these findings showed that LINC00858 exerted an ontogenetic role in HCC via regulating miR-153-3p/Rabl3 axis. Yes Knockdown of LINC00858 inhibited the proliferation and invasion of HCC cells. 33015775 LINC00858 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cells regulation[miR-134-5p/RAD18 signaling] RNA Pull-Down//Western Blot//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay LINC00858 were up-regulated in ovarian cancer tissues and cells, and its expression was elevated in advanced samples compared to early ones. Yes Knocking down LINC00858 inhibited cell proliferation, motility and EMT, but accelerated cell apoptosis in ovarian cancer. 32875345 LINC00858 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cell lines Interaction(miR-134-5p/TRIM44 axis) qRT-PCR//Western Blot Our results showed that LINC00858 was highly expressed in human ovarian cancer tissues and cell lines. Mechanistic studies revealed that LINC00858 acted as a sponge of miR-134-5p and then regulated TRIM44 expression in SKOV3 cells. Yes Knockdown of LINC00858 inhibited cell proliferation, migration and invasion of SKOV3 cells, and suppressed tumor growth in mouse xenograft models. 34423728 LINC00858 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cell lines Interaction(miR‑3064‑5p/CTGF axis) qRT-PCR//RIP The results revealed that the expression level of LINC00858 was upregulated in bladder cancer tissues and cell lines including T24, J82 and 5637. Mechanistically, LINC00858 functioned as a competitive RNA to increase the expression level of oncogene CTGF by sequestering miR-3064-5p. Yes Moreover, knockdown of LINC00858 suppressed cell proliferation, migration and invasion in vitro. 34132366 LINC00858 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells Interaction(miR-3064-5p/ VMA21 axis) RNA Pull-Down//Transfection//Tunel//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining The up-regulated LINC00858 was detected in CC cells.LINC00858 was determined to bind with miR-3064-5p and up-regulate VMA21 in CC cells. In rescue assays, miR-3064-5p down-regulation and VMA21 up-regulation were able to counteract the effect caused by LINC00858 decrease on CC cell proliferation and apoptosis. Yes Reduction of LINC00858 effectively subdued CC cells proliferation and stimulated cell apoptosis. 34275889 LINC00857 LncRNA Homo sapiens Lung Neoplasms regulation[LINC00857-YBX1-MET/p-AMPKa signaling] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP Collectively, LINC00857-YBX1-MET/p-AMPKa signaling is critical to regulate cell proliferation, apoptosis, and autophagy, which may provide a potential clinically therapeutic target in lung cancer. Yes The cell apoptosis and autophagy were induced upon LINC00857 silencing in lung cancer cells. 33312753 LINC00857 LncRNA Homo sapiens Colorectal Neoplasms cell  Interaction(miR-122-5p/SLC1A5/ASCT2 ) Western Blot//qRT-PCR//FISH//RIP//ChIP We screened out an HSF1-mediated super enhancer, lncRNA-LINC00857, which exerts its characteristics in promoting cell growth via regulating glutamine metabolism. Notably, HSF1 could stimulate the super-enhancer activity of LINC00857 by the enrichment of acetyltransferase P300 to its gene loci, contributing to LINC00857 transcription. In turn, nuclear LINC00857 cooperated with HSF1 to promote ANXA11 transcription, which modulated SLC1A5/ASCT2 protein expression by binding competitively to miR-122-5p. Yes We screened out an HSF1-mediated super enhancer, lncRNA-LINC00857, which exerts its characteristics in promoting cell growth via regulating glutamine metabolism. The knockout of ANXA11 attenuated colorectal cancer formation in vivo. 36010849 LINC00857 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-455-5p/LRP4 axis ) qRT-PCR In our study, the level of HUMT was enhanced in HCC tissues and cells. MiR-455-5p was a target of HUMT. Lowexpression of miR-455-5p reversed the inhibitive influence on HCC cells induced by of HUMT silencing. LRP4 was a target of miR-455-5p and was negatively regulated by miR-455-5p. In addition, LRP4 expression was positively modified by HUMT, and LRP4 inhibited the inhibitory effects on HCC cells induced by HUMT silencing. Yes Cell proliferation, invasion, and migration in HCC cells were repressed by knockdown of HUMT, and knockdown of HUMT arrested cells in G1 phase and decreased the levels of PCNA, MMP-2, and MMP-9. 35293286 LINC00886 LncRNA Homo sapiens laryngeal carcinoma tumor tissues and laryngeal cancer cell lines Expression[lower expressed] qRT-PCR//Western Blot The remarkable downregulation of LINC00886 was observed in tumor tissues and laryngeal cancer cell lines. Yes Over-expression of LINC00886 dramatically mitigated cell proliferation, migration, and invasion in vitro as well as suppressed tumor growth in vivo. 32111441 LINC00668 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation[miR-193a/KLF7 axis] ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In this study, we found that LINC00668 expression was significantly up-regulated in both NSCLC tissues and cell lines.Our findings suggested that STAT3-induced LINC00668 contributed to NSCLC progression through upregulating KLF7 expression by sponging miR-193a, and may serve as a prognostic biomarker and a potential target for NSCLC. Clinical investigation demonstrated that high expression level of LINC00668 was associated with advanced TNM stage, histological grade and lymph node metastasis. Yes Functional assays indicated that knockdown of LINC00668 suppressed NSCLC cells proliferation, migration and invasion, and promoted apoptosis. 31150989 LINC00887 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC patients Expression(highly expressed) Western Blot//Flow Cytometry//qRT-PCR//IHC//Transwell Assay As suggested by bioinformatics analysis, LINC00887 was markedly upregulated in ccRCC patients and associated with expression of immune-suppression molecule, thereby abating the immune infiltration level of CD8+ cells in tumor tissue. Yes As revealed by cellular assay, LINC00887 was upregulated in ccRCC cells, and knockdown of LINC00887 resulted in a decreased PD-L1 expression, increased CD8+ T cell toxicity, decreased apoptotic levels, and enhanced chemotaxis. 36060659 LINC00924 LncRNA Homo sapiens Carcinoma, Hepatocellular Interaction( miR-6755-5p/NDRG2 ) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Transwell Assay The LINC00924 downregulation in HBV-related HCC tissues and cells was revealed by reverse transcription-quantitative polymerase chain reaction. The binding site between LINC00924 and miR-6755-5p was determined by luciferase reporter assays. miR-6755-5p was confirmed to target NDRG2. miR-6755-5p upregulation decreased NDRG2 messenger RNA (mRNA) and protein levels. The mRNA and protein levels of NDRG2 were downregulated in tissues and cells. NDRG2 knockdown attenuated the inhibition induced by LINC00924 overexpression on invasion and EMT of HCC cells. Based on the bioinformatics analysis, LINC00924 downregulation is positively related to unfavorable outcomes in patients with HBV-related HCC. Yes Functionally, as Transwell assays and western blotting indicated, LINC00924 elevation inhibited HCC cell invasion and epithelial-mesenchymal transition (EMT). 34997970 LINC00922 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction( miR-204-5p/HMGA2 axis) IHC//Western Blot//Wound Healing Assay//Tunel//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Transwell Assay LINC00922 was upregulated in GC, and high LINC00922 expression was associated with poor prognosis.Besides, LINC00922 was markedly located in the cytoplasm. The mechanistic analysis demonstrated that LINC00922 acted as a sponge of miR-204-5p, thereby inhibiting the expression of the target gene-High Mobility Group AT-hook 2 (HMGA2). LINC00922 was upregulated in GC, and high LINC00922 expression was associated with poor prognosis. Yes Inhibition of LINC00922 suppressed GC cell proliferation, migration, invasion, and activated cell apoptosis in vitro and inhibited tumorigenesis in vivo. 35428261 LINC00922 LncRNA Homo sapiens Breast Neoplasms Breast cancer tissues regulation[promoting NKD2 methylation] qRT-PCR//RIP//ChIP The RNA extraction and quantification and immunohistochemical staining characterized the high expression of LINC00922 and low expression of NKD2 in breast cancer tissues in comparison to its adjacent counterparts. The current study provides evidence that LINC00922 acts as a tumor promoter by promoting NKD2 methylation. Hopefully, it provides a novel potential gene target for the treatment of breast cancer. Yes The ectopically expressed LINC00922 activated the Wnt signaling pathway, promoted epithelial-mesenchymal transition, cell proliferative, invasive and migratory capacities, tumor growth and metastasis. 33045317 LINC00922 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines Interaction(miR-361-3p/CLDN1) CCK8//qRT-PCR//Luciferase Report Assay//FISH LINC00922 was significantly upregulated in OC tissues and cell lines, which is significantly positively corelated with the poor prognosis of patients with OC. This study suggested that LINC00922 could competitively bind with miR-361-3p to promote the CLDN1 expression and activate Wnt/β-catenin signaling in OC progression, which providing a promising therapeutically target for OC. LINC00922 was significantly upregulated in OC tissues and cell lines, which is significantly positively corelated with the poor prognosis of patients with OC. Yes LINC00922 knockdown inhibited proliferation and tumorigenesis of OC cells in vitro and vivo. In addition, LINC00922 knockdown suppressed migration, invasion, and EMT of OC cells in vitro. 34116704 LINC00922 LncRNA Homo sapiens Liver Neoplasms HCC tissues Interaction(miR-424-5p/ARK5) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Bioinformatics Analysis//Transwell Assay MiR-424-5p was low expressed, whereas LINC00922 and ARK5 were high expressed in HCC tissues. MiR-424-5p was negatively associated with LINC00922 and ARK5 that was positively associated with LINC00922. Interestingly, LINC00922 partially shared an identical binding site of miR-424-5p with ARK5. Yes LINC00922 its overexpression partially offset the inhibitory effect of miR-424-5p on cancer cell functions. ARK5 silencing repressed the malignant phenotype of cancer cells and inhibited the expressions of epithelial-to-mesenchymal transition (EMT)-related molecules (Vimentin, Snail and N-Cadherin). However, these effects were partially neutralized by miR-424-5p inhibitors. 34097192 LINC00922 LncRNA Homo sapiens Colorectal Cancer Liver Metastasis CRC cell Interaction(Lnc-LALC/ LZTS1 axis) In Vivo Experiment//ChIP//Western Blot//Wound Healing Assay//Transfection//Migration Assay//qRT-PCR//RIP//H&E Staining//cell invasion assay//IHC//MSP We found that upregulated Lnc-LALC in CRC was negatively correlated with LZTS1 expression, and Lnc-LALC could regulate LZTS1 expression in both mRNA and protein level in our study. Furthermore, the precise mechanisms exploration showed that lnc-LALC could recruit DNA methyltransferases (DNMTs) to the LZTS1 promoter by combining with Enhancer of zeste homolog 2(EZH2) and then altered the expression of LZTS1 via DNMTs-mediated DNA methylation. Yes Functionally, Lnc-LALC enhanced the CRC cells metastasis ability in vitro and vivo through inhibiting the expression of LZTS1. 33637680 LINC00921 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells and tissues Interaction(miR-9-5p/LZTS2 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//IHC//Bioinformatics Analysis//Transwell Assay Low expression of linc00921 was observed in 49 of 95 TNBC tissues. A luciferase reporter assay showed that linc00921 could sponge miR-9-5p in TNBC. Moreover, linc00921 and miR-9-5p occupied the same Argonaute-2 (Ago2) protein in TNBC cells. Leucine zipper tumor suppressor 2 (LZTS2) was recognized as a target gene of miR-9-5p, and thereby a linc00921/miR-9-5p/LZTS2 axis was identified in TNBC cells. Low expression of linc00921 was correlated with poor postoperative disease-free survival (DFS) and overall survival (OS) of TNBC patients. Yes Overexpression of linc00921 with lentivirus suppressed the proliferation, migration and invasion of TNBC cells. Overexpression of linc00921 promoted nuclear export of β-catenin, neutralized its function, and subsequently promoted epithelial-to-mesenchymal transition (EMT) in TNBC. A xenograft tumor mouse model showed that the miR-9-5p inhibitor upregulates LZTS2 expression and induce nuclear export of β-catenin in TNBC. 35179718 LINC00920 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(microRNA-10a) CCK8//qRT-PCR LINRIS expression was upregulated in NSCLC tissues.LINRIS were positively correlated with mature (miR-10a) levels but not miR-10a precursor. Overall, LINRIS silencing may inhibit NSCLC cell proliferation by suppressing miR-10a maturation. High LINRIS levels predicted poor survival of NSCLC patients. Yes In NSCLC cells, LINRIS silencing showed no role in miR-10a precursor accumulation but downregulated mature miR10a level. Moreover, LINRIS silencing inhibited cell proliferation, while miR-10a overexpression increased cell proliferation and inhibited the role of LINRIS silencing. 35137650 LINC00920 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR//RNA Pull-Down//RIP LINRIS was upregulated in CRC tissues from patients with poor overall survival (OS), and LINRIS inhibition led to the impaired CRC cell line growth. Yes In vivo experiments showed that the inhibition of LINRIS suppressed the proliferation of tumors in orthotopic models and in patient-derived xenograft (PDX) models. 31791342 LINC00920 LncRNA Homo sapiens Prostatic Neoplasms regulation[14-3-3ε-FOXO Pathway] Western Blot//Immunoblotting//qRT-PCR//RIP//Luciferase Report Assay//ChIP Here, we leverage the International Cancer Genome Consortium-Early Onset Prostate Cancer transcriptome and identify the previously uncharacterized lncRNA LINC00920 to be upregulated in prostate tumors.Chromatin isolation by RNA purification-mass spectrometry revealed the interaction of LINC00920 with the 14-3-3ε protein, leading to enhanced sequestration of tumor suppressive FOXO1. Yes Phenotypic characterization of LINC00920 revealed its positive impact on cellular proliferation, colony formation, and migration. 32646965 LINC00908 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue regulation[KLF5 ] qRT-PCR We found that LINC00908 was significantly upregulated in CRC. Mechanistically, miR-143-3p directly targets LINC00908. The KLF5 inhibitor ML264 affected proliferation and apoptosis, indicating that LINC00908 may act as a competing endogenous RNA to facilitate the expression of the miR-143-3p target gene KLF5. Yes Inhibition of LINC00908 resulted in reduced cell proliferation and G1 cell cycle arrest, which was mediated by cyclin D1, cyclin-dependent kinase 4, and phosphorylated retinoblastoma. 33020901 LINC00899 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction[inhibiting miR-425] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Here, we found that LINC00899 is downregulated in breast cancer tissues and cell lines.These findings highlight the important role of the LINC00899-miR-425-DICER1 axis in breast cancer cell proliferation and invasion, and could potentially lead to new lncRNA-based diagnostics or therapeutics for breast cancer. Yes Functional assays indicated that LINC00899 overexpression suppresses proliferation, migration and invasion of breast cancer cells in vitro. 31739288 LINC00899 LncRNA Homo sapiens acute myeloid leukemia AML cells regulation[miR-744-3p/YY1 signalling] qRT-PCR Here, we demonstrated that lncRNA LINC00899 was upregulated in acute myeloid leukaemia (AML) cells and was quite correlated with poor prognosis of AML patients.YY1 is the downstream target of LINC00899/miR-744-3p signalling. Here, we demonstrated that lncRNA LINC00899 was upregulated in acute myeloid leukaemia (AML) cells and was quite correlated with poor prognosis of AML patients. Yes LncRNA LINC00899 mediates cell proliferation and apoptosis of acute myeloid leukaemia cells. Knockdown of LINC00899 inhibited the growth of xenograft glioma tumour in vivo. 32157707 LINC00891 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell lines Interaction(miR-128-3p/GATA2 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay//ChIP Here, we found that LINC00891 expression is downregulated in lung cancer tissues and cell lines compared with that in adjacent normal tissues and normal lung epithelial cells. Mechanistic research showed that GATA2 directly binds to LINC00891 promoter and transcriptionally regulates LINC00891 expression. Meanwhile, GATA2 was identified as a target of miR-128-3p, and it is negatively regulated by miR-128-3p. Moreover, overexpression of GATA2 suppresses lung cancer cell proliferation, invasion, migration, and EMT process. Yes LINC00891 overexpression impedes cell proliferation, invasion, migration and epithelial-to-mesenchymal transition (EMT) process in lung cancer cells. 35538035 LINC00888 LncRNA Homo sapiens Laryngeal Neoplasms laryngeal cancer cells Interaction(miR-378g/TFRC) Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay We observed that LINC00888 expression was notably increased in laryngeal cancer and associated with death, recurrence, and prognosis. Interestingly, we discovered that LINC00888 functioned as an miRNA sponge to suppress the effect of miR-378g on laryngeal cancer cells behaviors, as well as positively regulate TFRC expression. . We observed that LINC00888 expression was notably increased in laryngeal cancer and associated with death, recurrence, and prognosis. Yes Depletion of LINC00888 repressed the proliferative and motile abilities of laryngeal cancer cells in vitro. 34472153 LINC00887 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and the serum Expression[highly expressed] qRT-PCR We found that LINC00887 expression is significantly increased in early-stage RCC tissues and the serum of early-stage RCC patients compared to matched normal tissues and the serum of healthy subjects, respectively. Yes Furthermore, we found that LINC00887 promotes RCC cell proliferation in vitro. 32654370 LINC00887 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues or human cervical cancer cell lines (Hela, C33A) Interaction( miR-454-3p/FRMD6-Hippo axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay Linc00887 was downregulated in cervical cancer tissues or human cervical cancer cell lines (Hela, C33A) compared with normal tissues or cell lines. Linc00887 bound with miR-454-3p, and overexpression of miR-454-3p rescued linc00887-induced inhibition proliferation and invasion of HeLa cells. MiR-454-3p targeted and suppressed the expression of FRMD6, and linc00887 suppressed tumorigenesis of cervical cancer through activating the FRMD6-Hippo signaling pathway. Yes Overexpression of linc00887 inhibited proliferation and invasion HeLa and C33A cells, while linc00887 knockdown had the opposite effect. 33413358 LINC00857 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cells regulation[miR-486-5p,YAP1 ] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP The upregulation of LINC00857 was further determined in 50 ovarian cancer tissues by comparing their corresponding non‐tumor tissues (Figure S1B). In a word, this study unveiled that LINC00857 regulates YAP1 by competitively binding to miR-486-5p and accelerates ovarian cancer progression. Yes Functional experiments revealed that LINC00857 silencing led to the inhibition on cell proliferation, migration, invasion, and glycolysis but accelerated cell apoptosis in ovarian cancer. 32918541 LINC00857 LncRNA Homo sapiens pancreatic adenocarcinoma pancreatic adenocarcinoma cells Expression(highly expressed) qRT-PCR//Luciferase Report Assay LINC00857 upregulation promoted the proliferation and clone formation abilities of PAAD cells. Afterwards, the downstream miRNA and mRNA targets of LINC00857 were picked up to construct a ceRNA network. Further study revealed that TGFA expression was positively regulated by LINC00857 and negatively regulated by miR-340-5p. Besides that, the inhibitory effect of miR-340-5p on PAAD cells growth and movement can be blocked by LINC00857 upregulation. By enquiring TCGA database, we got that LINC00857 was highly expressed in patients with PAAD and positively associated with worse prognosis in PAAD patients. Yes the malignant behavior of PAAD cells induced by TGFA overexpression can be eliminated by LINC00857 knockdown. 33661995 LINC00857 LncRNA Homo sapiens Pancreatic Neoplasms PC cells Regulation(STAT3/CREB) Cell Proliferation Assay//qRT-PCR//qPCR//Western Blot We revealed that the knockdown of LINC00857 in PC cell lines inhibited the proliferation of the PC cells. We found that LINC00857 downregulation was followed by the downregulation of oncogenic proteins mesenchymal-epithelial transition (MET), signal transducer and activator of transcription 3 (STAT3), and cAMP response element-binding protein (CREB). Yes We revealed that the knockdown of LINC00857 in PC cell lines inhibited the proliferation of the PC cells. 35070392 LINC00857 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells Interaction( p53-LINC00857/FOXM1/OTUB1) RNA Pull-Down//ChIP//Wound Healing Assay//Co-IP//FISH//RIP//Luciferase Report Assay//Transwell Assay In the present study, we demonstrated that the lncRNA LINC00857 exhibits a significantly elevated level in PC and that it is associated with poor prognosis; furthermore, TCGA data showed that LINC00857 expression was significantly upregulated in the mutant p53 group compared with the wild-type p53 group.Mechanistically, LINC00857 bound simultaneously to FOXM1 and to the deubiquitinase OTUB1, thereby serving as a protein scaffold and enhancing the interaction between FOXM1 and OTUB1, which inhibits FOXM1 degradation through the ubiquitin-proteasome pathway. Yes Gain- and loss-of-function experiments showed that LINC00857 promotes the metastasis of PC cells. We further found that LINC00857 upregulates FOXM1 protein expression and thus accelerates metastasis in vitro and in vivo. 36272615 LINC00680 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cell Interaction(GATA6-SOX12 axis ) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//FISH//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay LINC00680 has been characterized as a novel oncogenic lncRNA in LUAD, In summary, this study revealed a novel LINC00680-GATA6-SOX12 axis in promoting LUAD cell cycle progression and proliferation. Yes Results showed LINC00680 depletion resulted in G0/G1 phase arrest of LUAD cells and reduced CDK4 and cyclin D1 expression in H1650 and H1299 cells. LINC00680 overexpression promoted A549 cell proliferation and increased CDK4 and cyclin D1 expression. 34029572 LINC00680 LncRNA Homo sapiens Myasthenia Gravis peripheral blood mononuclear cells of patients with MG Interaction(miR-320a/MAPK1) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Bioinformatics Analysis Compared with control subjects, the expression levels of LINC00680 and mitogen-activated protein kinase 1 (MAPK1) in peripheral blood mononuclear cells of patients with MG were both upregulated; the levels of miR-320a were downregulated. A positive correlation was detected between LINC00680 expression and the severity of MG. Luciferase reporter assays identified that LINC00680 acts as a target for miR-320a. The in vitro analysis confirmed that LINC00680 regulates the expression of MAPK1 by sponging miR-320a. Finally, the functional analysis indicated that LINC00680 promoted Jurkat cell proliferation and inhibited cellular apoptosis by sponging miR-320a. Yes Finally, the functional analysis indicated that LINC00680 promoted Jurkat cell proliferation and inhibited cellular apoptosis by sponging miR-320a. 35800083 Linc00673 LncRNA Homo sapiens Stomach Neoplasms cell line MGC-803 Regulation(PI3K/Akt signaling pathway) Flow Cytometry//MTT//Colony Formation Assay//Western Blot The expressions of Linc00673 in gastric cancer cell line MGC-803, BGC-823 and AGS were significantly higher than that in normal gastric mucosa cell line GES-1 (P＜0.05). MGC-803 cell line with stable overexpression of LINC00673 was established, and the expression level of LincC00673 was 200 times higher than that of the control empty carrier group. Western blot showed that Linc00673 overexpression not only promoted the expressions of the key molecule pAkt in PI3K / Akt signaling pathway and its downstream target NF-κ B and Bcl-2 protein, but also up regulated the expressions of tumor related factors β-catenin and EZH2 proteins. Yes Overexpression of Linc00673 promoted proliferation of MGC-803 cells (P＜0.05) and clone formation (P＜0.05), inhibited cell apoptosis and affected the G1→S phase progression of cell cycle (P＜0.01). Overexpression of Linc00673 could affect the expressions of cell cycle regulatory gene CCNG2, P19 and CDK1 in MGC-803. 35634670 LINC00673 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[B7-H6 ] qRT-PCR//Western Blot We discovered that LINC00673 is significantly upregulated in breast cancer tissues compared to paired adjacent non-tumor tissues by RT-qPCR and highly expressed LINC00673 is positively correlated with lymph node metastasis and clinical stage in the validated cohort.Gene expression profiling results indicated that LINC00673 could influence NCR3LG1(B7-H6) expression in transcriptional level. We discovered that LINC00673 is significantly upregulated in breast cancer tissues compared to paired adjacent non-tumor tissues by RT-qPCR and highly expressed LINC00673 is positively correlated with lymph node metastasis and clinical stage in the validated cohort. Yes Knocking down LINC00673 inhibited cell proliferation and metastasis, whereas upregulated LINC00673 had the opposite effect. 30094100 LINC00673 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[miR-515-5p/MARK4/Hippo signaling pathway] qRT-PCR//Luciferase Report Assay//RNA-seq//ChIP In the present study, LINC00673 displayed a trend of remarkably increased expression in breast cancer tissues and was associated with poor prognosis in breast cancer patients. YY1-activated LINC00673 may exert an oncogenic function by acting as a sponge for miR-515-5p to upregulate the MARK4 and then inhibit Hippo signaling pathway, and may serve as a potential therapeutic target. In the present study, LINC00673 displayed a trend of remarkably increased expression in breast cancer tissues and was associated with poor prognosis in breast cancer patients. Yes Importantly, LINC00673 depletion inhibited breast cancer cell proliferation by inhibiting the cell cycle and increasing apoptosis. Furthermore, ASO therapy targeting LINC00673 substantially suppressed breast cancer cell proliferation in vivo. 31623640 LINC00673 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues,cell lines regulation[EZH2-Mediated H3K27 Trimethylation] Western Blot//Flow Cytometry//qRT-PCR//FISH//ChIP Up-regulated LINC00673 was associated with poor prognosis in ESCC patients and promoted the proliferation of ESCC cells both in vitro and in vivo.The present findings are the first to reveal that LINC00673 represses CDKN2C expression and promotes ESCC cell proliferation by elevating EZH2-mediated H3K27me3 levels. Up-regulated LINC00673 was associated with poor prognosis in ESCC patients and promoted the proliferation of ESCC cells both in vitro and in vivo. Yes Up-regulated LINC00673 was associated with poor prognosis in ESCC patients and promoted the proliferation of ESCC cells both in vitro and in vivo.Compared to the control group, depletion of LINC00673 in ESCC cells arrested the cell cycle, at least, at the G1/S checkpoint. 33014799 LINC00673 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines Interaction[EZH2 and DNMT1] Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay//ChIP LINC00673 expression in PTC tissues was significantly higher than that of the adjacent normal tissues. RIP and ChIP assay demonstrated that LINC00673 could bind to EZH2 and DNMT1. Besides, Western blot analysis showed that LINC00673 negatively regulated p53 expression. In addition, the knockdown of p53 in K1 and TPC-1 cells partially reversed the inhibitory effect of LINC00673 deficiency on the proliferation and metastasis of PTC cells. Besides, higher expression of LINC00673 indicated worse prognosis of PTC. Yes The knockdown of LINC00673 in K1 and TPC-1 cells markedly reduced the proliferative rate. Meanwhile, LINC00673 down-regulation remarkably inhibited the migratory and invasive capacities of K1 and TPC-1 cells. 30915752 LINC00673 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cancer cell lines regulation[PTEN/PI3K/AKT signaling pathway] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay It was confirmed that the relative mRNA expression of LINC00673 was promoted in cervical cancer tissues and cancer cell lines compared with its corresponding normal tissues and cells (P < 0.05).These results provide the evidence that LINC00673 overexpression promotes cervical cancer cells progression through regulating miR-126-5p and activating the PTEN/PI3K/AKT signaling pathway, indicating that LINC00673 may be a potential therapeutic target for cervical cancer treatment. Higher LINC00673 expression was associated with tumor size, lymph node metastasis, and International Federation of Gynecology and Obstetrics (FIGO) stage (P < 0.05). Survival analysis showed higher LINC00673 expression predicted poor OS of cervical cancer patients, and Multivariate Cox analysis demonstrated that higher LINC00673 expression was identified as an independent risk factor for OS. Yes LINC00673 overexpression promoted cell proliferation and cell cycle progression, but LINC00673 knockdown inhibited cell proliferation and cell cycle progression significantly (P < 0.05). 32950808 LINC00673 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer patients Expression(highly expressed) In Vivo Experiment//Western Blot//qRT-PCR//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay Our results revealed that serum LINC00673 levels were highest in cervical cancer patients, followed by patients with CIN and healthy controls. Western blotting showed that cell cycle-related proteins cyclin A2 and cyclin E and interstitial-associated proteins Snail and N-cadherin were upregulated and p53 signaling pathway-related proteins were downregulated in LINC00673-overexpressing HeLa and SiHa cells. Our results revealed that serum LINC00673 levels were highest in cervical cancer patients, followed by patients with CIN and healthy controls. Yes In vitro experiments demonstrated that overexpression of LINC00673 enhanced the proliferation and cell cycle progression of HeLa and SiHa cells. In vivo experiments showed that the tumor weight and volume of nude mice subcutaneously injected with LINC00673-overexpressing HeLa cells were larger than those of nude mice injected with control cells (P < 0.05). 34094965 LINC00673 LncRNA Homo sapiens Glioma glioma cells Regulation(PI3K/AKT signaling pathway) Western Blot//Transfection//Migration Assay//qRT-PCR//Invasion Assay In this study, we examined its expression in glioma cells by quantitative real-time PCR and found higher expression of LINC00673 in glioma cells compared with that in normal human astrocytes. Furthermore, LINC00673 silencing inhibited the migration and invasion of U87MG and U118MG cells, phosphoinositide 3-kinase (PI3K) expression, and AKT phosphorylation. Moreover, activation of the PI3K/AKT signaling pathway by insulin-like Growth factor-1 abolished the inhibitory effect of LINC00673 silencing on the migration and invasion of U87MG and U118MG cells. Yes Furthermore, LINC00673 silencing inhibited the migration and invasion of U87MG and U118MG cells, phosphoinositide 3-kinase (PI3K) expression, and AKT phosphorylation. Moreover, activation of the PI3K/AKT signaling pathway by insulin-like Growth factor-1 abolished the inhibitory effect of LINC00673 silencing on the migration and invasion of U87MG and U118MG cells. 29621055 LINC00673 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and serums Expression[highly expressed] qRT-PCR//MTT The results showed that LINC00346, LINC00578, and LINC00673 were highly expressed, whereas LINC00671, LINC00261, and SNHG9 were lowly expressed in PC tissues and serums, and their expression levels were correlated with clinical stages. Survival analysis indicated that patients with high expression of LINC00346, LINC00578, or LINC00673 had significantly lower survival rate, while patients with high expression of LINC00671, LINC00261, and SNHG11 had significantly higher survival rate. Yes In addition, we also found that silence of LINC00346, LINC00578 and LINC00673 inhibited PC cell proliferation, and silence of LINC00671, LINC00261, and SNHG11 promoted PC cell proliferation. 30210701 LINC00673 LncRNA Homo sapiens Adenocarcinoma of Lung cell lines Regulation[WNT/β-catenin signaling] qRT-PCR Here we reported that a long noncoding RNA, LINC00673, was up-regulated in LAD cells.Together, our data suggest that LINC00673-v4 is a driver molecule for metastasis via constitutively activating WNT/β-catenin signaling in LAD and may represent a potential therapeutic target against the metastasis of LAD. Yes In vitro and in vivo experiments demonstrated that LINC00673-v4 enhanced invasiveness, migration, and metastasis of LAD cells. 31235588 LINC00673 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues Regulation[KLF2] CCK8//qRT-PCR//Western Blot//Transwell Assay The study revealed that long non?coding RNA LINC00673 was significantly upregulated in thyroid cancer tissues compared with paired adjacent non?tumor tissues using RT-qPCR and that high expression of LINC00673 is was associated with larger tumor size and lymph node metastasis in the validated cohort. The results showed that LINC00673 may influence EMT and the expression of Kruppel-like factor 2 (KLF2). The study revealed that long non?coding RNA LINC00673 was significantly upregulated in thyroid cancer tissues compared with paired adjacent non?tumor tissues using RT-qPCR and that high expression of LINC00673 is was associated with larger tumor size and lymph node metastasis in the validated cohort. Yes Knockdown of LINC00673 inhibited cell proliferation and metastasis, whereas, LINC00673 overexpression had the opposite effect. 30106140 LINC00673 LncRNA Homo sapiens Diabetic Retinopathy plasma samples of DR patients Regulation(p53 ) Western Blot//Transfection//qRT-PCR//Cell Apoptosis Assay//ELISA LINC00673 was downregulated in plasma samples of DR patients (n=60) in comparison with the healthy controls (n=60) and negatively correlated with p53 only across DR patients but not across the healthy controls. In retinal pigment epithelial cells (RPECs), high glucose treatment downregulated LINC00673. Moreover, LINC00673 overexpression downregulated p53 and decreased RPEC apoptosis, while LINC00673 silencing upregulated p53 and increased RPEC apoptosis. In addition, p53 overexpression reduced the effects of LINC00673 overexpression. Yes LINC00673 was downregulated in plasma samples of DR patients (n=60) in comparison with the healthy controls (n=60) and negatively correlated with p53 only across DR patients but not across the healthy controls. In retinal pigment epithelial cells (RPECs), high glucose treatment downregulated LINC00673. Moreover, LINC00673 overexpression downregulated p53 and decreased RPEC apoptosis, while LINC00673 silencing upregulated p53 and increased RPEC apoptosis. In addition, p53 overexpression reduced the effects of LINC00673 overexpression. 34675574 LINC00671 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and serums Expression[lower expressed] qRT-PCR//MTT The results showed that LINC00346, LINC00578, and LINC00673 were highly expressed, whereas LINC00671, LINC00261, and SNHG9 were lowly expressed in PC tissues and serums, and their expression levels were correlated with clinical stages. Survival analysis indicated that patients with high expression of LINC00346, LINC00578, or LINC00673 had significantly lower survival rate, while patients with high expression of LINC00671, LINC00261, and SNHG12 had significantly higher survival rate. Yes In addition, we also found that silence of LINC00346, LINC00578 and LINC00673 inhibited PC cell proliferation, and silence of LINC00671, LINC00261, and SNHG12 promoted PC cell proliferation. 30210701 LINC00671 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells Interaction(miR-221-5p/SOCS1 axis) Western Blot//Transfection//Invasion Assay//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay LINC00671 expression in RCC tissues and cells was significantly reduced.In terms of mechanism, miR-221-5p was identified as a target of LINC00671, and LINC00671 could up-regulate SOCS1 by repressing miR-221-5p. Patients with low LINC00671 expression had relatively shorter disease-free survival and overall survival. Moreover, LINC00671 expression was linked to lymph node metastasis, tumor stage, and tumor size. Yes In Caki-1 and 769-P cell lines, LINC00671 overexpression restrained the multiplication, migration, invasion, as well as the EMT process of RCC cells in vitro. 34377233 LINC00671 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer Interaction( STAT3/LINC00671/LDHA axis) In Vivo Experiment//Migration Assay//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//ChIP Here, we identified a novel lncRNA LINC00671 negatively correlated with LDHA, downregulating LDHA expression and predicting good clinical outcome in thyroid cancer. Our work established STAT3/LINC00671/LDHA as a critical axis to regulate PTC growth and progression. Yes hypoxia inhibits LINC00671 expression and activates LDHA expression largely through transcriptional factor STAT3. STAT3/LINC00671/LDHA axis regulates thyroid cancer glycolysis, growth, and lung metastasis both in vitro and in vivo. 34404767 LINC00668 LncRNA Homo sapiens Stomach Neoplasms GC tissue and cells Regulation(PKN2 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Bioinformatics Analysis//Transwell Assay We found that LINC00668 level was upregulated in GC tissue and cells and predicted poor prognosis. Mechanistically, HuR was predicted to bind with LINC00668 and protein kinase N2 (PKN2). RNA pull-down assays validated the binding between HuR and LINC00668 (or PKN2). Moreover, either silencing of LINC00668 or HuR could decrease PKN2 mRNA stability or reduce PKN2 mRNA and protein levels. We found that LINC00668 level was upregulated in GC tissue and cells and predicted poor prognosis. Yes Functionally, LINC00668 knockdown suppressed GC cell migration and invasion. Additionally, LINC00668 knockdown inhibited epithelial to mesenchymal transition (EMT) process. PKN2 exerts similar effects with LINC00668 in GC cells. LINC00668 knockdown suppressed tumor growth and metastasis in vivo. 33879018 LINC00668 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//IHC//EdU Staining Both TCGA data and BC tissues harvested from our hospital indicated the higher expression of LINC00668 in BC tissues. LINC00668 expression was negatively correlated to prognosis of BC patients. Yes Besides, LINC00668 knockdown in BC cells induced apoptosis and arrested cell cycle.In vivo experiments demonstrated the decreased proliferative rate in tumor-bearing mice administrated with sh-LINC00668 transfected BC cells. 31371999 LINC00680 LncRNA Homo sapiens Osteoarthritis chondrocytes Interaction(SIRT1 ) CCK8//RIP Here, we found that a m6A-related lncRNA LINC00680 upregulated in the OA tissue and IL-1β-induced isolated primary chondrocytes. Mechanistically, m6A methyltransferase METTL3 combined tithe the m6A site of LINC00680 to up-regulate its expression. Moreover, LINC00680 interacted with SIRT1 mRNA through binding at m6A site on SIRT1 mRNA 3'-UTR, thereby enhancing the stability of SIRT1 mRNA. Yes Functionally, in IL-1β-induced chondrocytes, silencing of LINC00680 recovered the proliferation and repressed the extracellular matrix (ECM) degradation. 35501316 LINC00680 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues or cell lines Interaction(miR-423-5p/PAK6 axis) CCK8//qRT-PCR Notably, LINC00680 was highly expressed, and upregulation of LINC00680 was associated with large tumor size, advanced tumor stage, and poor prognosis. Mechanistically, LINC00680 was found to act as a ceRNA by sponging miR-423-5p to regulate PAK6 (p21-activated kinase 6) expression in ESCC cells. The cell viability and motility inhibition induced by LINC00680 knockdown was significantly reversed upon PAK6 restoration and miR-423-5p inhibition. Yes Functionally, knockdown of LINC00680 restrained ESCC cell proliferation, colony formation, migration, and invasion in vitro and inhibited tumor growth in vivo. Furthermore, ASO targeting LINC00680 substantially suppressed ESCC both in vitro and in vivo. 35255921 LINC00682 LncRNA Homo sapiens Stomach Neoplasms GC tissues Regulation[miR-9-LMX1A signaling axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Results show that LINC00682 levels are significantly downregulated in cancer tissues (“Can”) (Figure 4L), when compared to those in the adjacent epithelial (“Epi”) tissues (Figure 4L). Therefore, LINC00682 downregulation correlates with miR-9 upregulation and LMX1A downregulation in GC tissues (see the results from same set of tissue samples [9]). In the primary human GC cells, forced LINC00682 overexpression similarly induced miR-9 downregulation and LMX1A upregulation, causing proliferation inhibition and apoptosis activation. Significantly, restoring miR-9 expression by a lentiviral construct reversed LINC00682-induced actions in GC cells. Furthermore, LINC00682 was ineffective in LMX1A KO AGS cells. Importantly, LINC00682 expression levels are significantly downregulated in human GC tissues. We conclude that LINC00682 inhibits GC cell progression via targeting miR-9-LMX1A signaling axis. Yes We show that ectopic overexpression of LINC00682 induced miR-9 downregulation but LMX1A upregulation, inhibiting AGS cell survival, proliferation, migration and invasion. 31822638 LINC00839 LncRNA Homo sapiens Neuroblastoma NB tumor tissues and cells Regulation(miR-454-3p to Up-Regulate NEUROD1) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//EdU Staining LINC00839 was found as a potential driver of NB progression. LINC00839 expression was higher in NB tumor tissues and cells. Also, LINC00839 expression was positively correlated with MYCN amplification, advanced INSS stages, and worse prognosis. Silencing of LINC00839 suppressed cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro. Mechanistically, LINC00839 could act as a sponge of miR-454-3p to facilitate the expression of its target NEUROD1. Moreover, miR-454-3p was demonstrated to exert an anti-cancer activity in NB. More importantly, the tumor-suppressive properties mediated by LINC00839 knockdown were significantly counteracted by the inhibition of miR-454-3p or overexpression of NEUROD1. Our study demonstrates that LINC00839 exerts an oncogenic role in NB through sponging miR-454-3p to up-regulate NEUROD1 expression, deepening our comprehension of lncRNA involved in NB and providing access to the possibility of LINC00839 as a therapeutic target for NB. Also, LINC00839 expression was positively correlated with MYCN amplification, advanced INSS stages, and worse prognosis. Yes Silencing of LINC00839 suppressed cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro. Mechanistically, LINC00839 could act as a sponge of miR-454-3p to facilitate the expression of its target NEUROD1. 35606572 LINC00857 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues , cell lines(BEAS-2B) Regulation[targeting miR-1179/SPAG5 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay In this study, we explored the expression of LINC00857 in lung adenocarcinoma (LUAD) tissues and LUAD cell lines and found a dramatical upregulation of LINC00857 compared with the adjacent normal lung tissues and BEAS-2B cell line, respectively. Yes Then, LINC00857 knockdown led to the cell proliferation and glycolysis was repressed, while the apoptosis was elevated in LUAD cell lines. 31667785 LINC00852 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumors and NSCLC cell lines Interaction( hsa-miR-145-5p/KLF4 axis) qRT-PCR//Cell Cycle Assay//Luciferase Report Assay LINC00852 is up-regulated in both NSCLC tumors and NSCLC cell lines. Moreover, the hsa-miR-145-5p/KLF4 axis was demonstrated to be directly regulated by LINC00852 in NSCLC. Inhibiting hsa-miR-145-5p or overexpressing KLF4 could reverse the LINC00852-down-regulation-induced anti-cancer effects on NSCLC cancer cell proliferation and chemoresistance. High LINC00852 expression was significantly correlated with NSCLC patients' short overall survival. Yes In NSCLC cell lines, LINC00852 down-regulation had anti-cancer effects by suppressing cancer cell proliferation, cisplatin chemoresistance and cell-cycle transition in vitro, as well as explant growth in vivo. 34342374 LINC00852 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell Interaction(miR-625/E2F1 Axis) qRT-PCR LINC00852 bound miR-625 which further targeted E2F1. Overexpressing miR-625 or down-regulating E2F1 reversed the oncogenic effects of LINC00852. Yes Overexpression of LINC00852 was positively associated with HCC cell proliferation, invasion and migration while negatively associated with the cell apoptosis. 35401844 LINC00847 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC samples and cell lines Interaction(miR-147a/IFITM1 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining Increased expressions of LINC00847 were observed in NSCLC samples as well as cell lines. Additionally, E2F1 could be capable of directly binding to the LINC00847 promoter region, followed by promoting its expression. Mechanically, miR-147a/IFITM1 axis was a downstream target of LINC00847, and silencing of miR-147a could rescue the anti-cancer effects of LINC00847 knockdown on NSCLC cell behaviors. X Clinically, LINC00847 high-expression could lead to poor prognosis of NSCLC patients. Yes Functionally, LINC00847 knockdown noticeably repressed NSCLC cell growth and metastasis. Mechanically, miR-147a/IFITM1 axis was a downstream target of LINC00847, and silencing of miR-147a could rescue the anti-cancer effects of LINC00847 knockdown on NSCLC cell behaviors. 33968966 LINC00844 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[MAPK signaling] qRT-PCR//Transwell Assay//Western Blot LINC00844 was found to be significantly decreased in HCC tissue and was correlated with poor tumor characteristics, such as portal vein invasion, high α-fetoprotein (AFP), and a high rate of tumor recurrence.Mechanistic analyses indicated that the mitogen-activated protein kinase (MAPK) signaling pathway was remarkably inactivated by LINC00844. Furthermore, the immunoprecipitation assay verified that LINC00844 can bind to zinc-alpha-2-glycoprotein (AZGP1) and interfere with its translocation. LINC00844 can also promote AZGP1 expression, leading to the suppression of the transforming growth factor-β1 (TGF-β1)-extracellular signal-regulated kinase (ERK) pathway. LINC00844 was found to be significantly decreased in HCC tissue and was correlated with poor tumor characteristics, such as portal vein invasion, high α-fetoprotein (AFP), and a high rate of tumor recurrence. Yes Exotic LINC00844 expression in HCC cell lines significantly suppressed proliferation and migration, as well as invasiveness, whereas LINC00844 deletion had the opposite effect. LINC00844 overexpression significantly inhibited HCC tumorigenesis in vivo. 33313110 LINC00839 LncRNA Homo sapiens Lung Neoplasms LC cells Interaction(miR-519d-3p/JMJD6 axis ) Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Invasion Assay//Transwell Assay LINC00839 was upregulated in LC cells and its knockdown resulted in reduced cell viability, migratory ability and invasion with increased cell apoptosis.MiR-519d-3p was the target gene of LINC00839 and its expression was reduced by LINC00839 overexpression. JMJD6 was directly targeted and suppressed at the level of mRNA and protein expression by miR-519d-3p. Yes LINC00839 was upregulated in LC cells and its knockdown resulted in reduced cell viability, migratory ability and invasion with increased cell apoptosis. 34734406 LINC00839 LncRNA Homo sapiens Liver Neoplasms liver cancer tissues and cell lines Regulation(FMNL2) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Transwell Assay LINC00839 expression was up-regulated in liver cancer tissues and cell lines, and the patients with high LINC00839 expression had shortened overall survival. Mechanistically, LINC00839 bound multiple proteins that were primarily associated with the metabolism and RNA transport, and positively regulated the expression of Formin-like protein 2 (FMNL2). LINC00839 expression was up-regulated in liver cancer tissues and cell lines, and the patients with high LINC00839 expression had shortened overall survival. Yes LINC00839 further overexpressed under hypoxia and promoted liver cancer cell proliferation, migration, and invasion. 36335129 LINC00839 LncRNA Homo sapiens Neuroblastoma neuroblastoma tissues and cell lines Interaction(miR-338-3p/GLUT1 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LINC00839 and GLUT1 abundances were increased in neuroblastoma tissues and cell lines. The high expression of LINC00839 and GLUT1 indicated the lower overall survival. LINC00839 interference constrained neuroblastoma cell proliferation, migration, invasion and glycolysis, and facilitated apoptosis. GLUT1 overexpression or miR-338-3p knockdown could mitigate the influence of LINC00839 silence on neuroblastoma cell processes. LINC00839 could regulate GLUT1 expression via miR-338-3p. LINC00839 knockdown reduced neuroblastoma cell growth in xenograft model. The high expression of LINC00839 and GLUT1 indicated the lower overall survival. Yes GLUT1 overexpression or miR-338-3p knockdown could mitigate the influence of LINC00839 silence on neuroblastoma cell processes. LINC00839 could regulate GLUT1 expression via miR-338-3p. LINC00839 knockdown reduced neuroblastoma cell growth in xenograft model. 34188473 LINC00707 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction[VAV3/F11R ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//migration assay "In this study, we identified that LINC00707 was excessively expressed in GC tissues and correlated with advanced stage, larger tumor size, lymph node metastasis and poorer prognosis in GC patients. Mechanistically, LINC00707 could abundantly interact with mRNA stabilizing protein HuR; ""LINC00707-HuR"" coalition ulteriorly combined with VAV3/F11R mRNAs and increased their stability. " In this study, we identified that LINC00707 was excessively expressed in GC tissues and correlated with advanced stage, larger tumor size, lymph node metastasis and poorer prognosis in GC patients. Yes In vitro and in vivo assays showed that LINC00707 promote GC cell proliferation and metastasis. 30502359 LINC00689 LncRNA Homo sapiens Glioma glioma cells Interaction(miR-526b-3p/IGF2BP1 Axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay LINC00689 was upregulated in glioma cells, while miR-526b-3p was downregulated.In conclusion, silencing of LINC00689 could inhibit the tumorigenesis of glioma via mediation of miR-526b-3p/IGF2BP1 axis. LINC00689 may serve as a new target for the treatment of glioma. Yes Moreover, LINC00689 knockdown or upregulation of miR-526b-3p inhibited the proliferation of glioma cells and induced the apoptosis. Consistently, the migration and invasion of glioma cells were notably reduced by LINC00689 shRNA/miR-526-3p mimics. miR-526b-3p inhibitor or IGF2BP1 upregulation could reverse the effect of LINC00689 knockdown or miR-526b-3p mimics. Finally, knockdown of LINC00689 inhibited the tumor growth of glioma in vivo through regulating miR-526b-3p/IGF2BP1/MAPK axis. 33389570 LINC00707 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines regulation[miR-30c/CTHRC1 regulatory loop] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LINC00707 was significantly upregulated in BC tissues and cell lines. It promoted cell proliferation, invasion, and migration via miR-30c/CTHRC1 regulatory loop. Yes The knockdown of LINC00707 inhibited proliferation, invasion, and migration in MDA-MB-231 cells, while the overexpression of LINC00707 achieved the opposite results in MDA-MB-468 cells. 32432749 LINC00707 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue,cell lines Interaction[(miR)-485-5p] CCK8//qRT-PCR//Luciferase Report Assay The expression level of LINC00707 was confirmed by RT-qPCR in 65 paired CRC tissues and matched NCTs. The results revealed that LINC00707 expression was significantly increased in tumor tissues compared with that in the corresponding NCTs (P<0.001; Fig. 1A and B). Furthermore, bioinformatics analysis demonstrated that microRNA (miR)-485-5p could directly bind to LINC00707, which was confirmed by a dual-luciferase reporter assay. The upregulation of LINC00707 expression was significantly associated with tumor size, stage and poor survival in patients with CRC. Yes Functional analyses revealed that the knockdown of LINC00707 could inhibit CRC cell proliferation. 32010320 LINC00707 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Regulation[ ERK/JNK/AKT pathway signaling pathway] qRT-PCR//Colony Formation Assay We observed that LINC00707 was upregulated in HCC cell lines compared with normal liver cell lines.Taking the above results together, it was implied in our study that LINC00707 contributed to HCC progression through modulating the ERK/JNK/AKT pathway. Yes LINC00707 silencing could greatly repress the proliferation and colony formation of HCC cells in vitro. On the contrary, overexpression of LINC00707 induced HCC cell proliferation and colony formation. 30317590 LINC00707 LncRNA Homo sapiens Glioma glioma tissues,cell lines regulation[ LINC00707/miR-613] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay LINC00707 was up-regulated in gliomas. The regulatory axis of LINC00707/miR-613 provides new insights into the mechanism and treatment of gliomas. Yes Up-regulated LINC00707 increased the proliferation, migration and invasion of glioma cells, and silenced LINC00707 reduced these abilities. 33107401 LINC00691 LncRNA Homo sapiens Stomach Neoplasms Clinical tissue and serum samples regulation[JAK/STAT signalling pathway] qRT-PCR//Western blot//Luciferase Report Assay Our data indicated that the expression of LINC00691 in GC was significantly higher than that in healthy controls and was associated with clinicopathological features and survival time.LINC00691 promotes the proliferation and invasion of GC cells by activating Lin28 transcription and facilitating EGF expression through the JAK/STAT signalling pathway, which provides new ideas for targeted therapy of GC. Our data indicated that the expression of LINC00691 in GC was significantly higher than that in healthy controls and was associated with clinicopathological features and survival time. Yes In the GC cell lines MKN-45 and HGC-27, the knockdown of LINC00691 suppressed proliferation, colony formation, migration, and invasion. 32330554 LINC00691 LncRNA Homo sapiens Osteosarcoma cell lines regulation[LINC00691/miR-1256/ST5 pathway] CCK8//qRT-PCR//RNA Pull-Down//Transwell Assay Expression analysis showed that the levels of lncRNA LINC00691 in osteosarcoma cells were decreased compared to those of control cells. The LINC00691/miR-1256/ST5 pathway plays an important role in the progression and metastasis of osteosarcoma and represents a good therapeutic target. Yes Overexpression of LINC00691 could inhibit the proliferation, migration, invasion, and induction of G1 cell cycle arrest in osteosarcoma cells, which was shown through in vitro and in vivo studies. 33380807 LINC00689 LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[ADAM9 ,miR-526b-3p] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We found that LINC00689 was upregulated in GC tissues and positively correlated with advanced tumor stage and tumor size, while miR-526b-3p was downregulated. Our study suggests that LINC00689 functions as a novel oncogenic lncRNA in the development of GC by promoting ADAM9 expression through suppression of miR-526b-3p. We found that LINC00689 was upregulated in GC tissues and positively correlated with advanced tumor stage and tumor size, while miR-526b-3p was downregulated. Yes Furthermore, gain- and loss-of-function experiments revealed that LINC00689 promoted the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of GC cells, while miR-526b-3p had the opposite effects. 32581594 LINC00689 LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[miR-338-3p/PKM2 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay The analysis of our data indicated that the expression of LINC00689 was up-regulated in glioma tissues and cell lines. Yes Further investigation demonstrated that LINC00689 knockdown markedly repressed the proliferation, migration, invasion and glycolysis of glioma cells. Additionally, silencing of LINC00689 significantly suppressed the growth of glioma cells in vivo. 31181442 LINC00525 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cells and tissues Regulation( p21 / EZH2 and RBMS2) Western Blot//Transfection//qPCR//Colony Formation Assay//FISH//qRT-PCR//Luciferase Report Assay//IHC LINC00525 is highly expressed in LUAD cells and tissues. Survival analysis indicated that upregulation of LINC00525 was associated with poor prognosis in patients with LUAD patients. Knockdown of LINC00525 inhibited cell proliferation and cell cycle progression in vitro. In xenograft models, LINC00525 knockdown suppressed tumor growth and tumorigenesis of tumor-bearing mice. Survival analysis indicated that upregulation of LINC00525 was associated with poor prognosis in patients with LUAD patients. Yes Knockdown of LINC00525 inhibited cell proliferation and cell cycle progression in vitro. In xenograft models, LINC00525 knockdown suppressed tumor growth and tumorigenesis of tumor-bearing mice. Mechanistically, LINC00525 epigenetically suppressed p21 transcription by guiding Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit (EZH2) to the p21 promoter through an formation of RNA-DNA triplex with the p21 promoter, leading to increased trimethylation of lysine 27 on histone 3 (H3K27me3) of the p21 promoter. 34105888 LINC02908 LncRNA Homo sapiens Leukemia, Myeloid, Acute acute myeloid leukemia cell Interaction(miR-24-3P/TAOK1 ) qRT-PCR//Western Blot LncRNA C9ORF139 regulates TAOK1 by sponging miR-24-3P to promote the proliferation, invasion and migration of acute myeloid leukemiacell.In vivo experiments have confirmed that the expression of C9ORF139 can promote the growth of subcutaneous tumors in AML nude mice. Yes LncRNA C9ORF139 regulates TAOK1 by sponging miR-24-3P to promote the proliferation, invasion and migration of acute myeloid leukemiacell.In vivo experiments have confirmed that the expression of C9ORF139 can promote the growth of subcutaneous tumors in AML nude mice. 35196780 LINC00460 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(IGF2BP2 and DHX9 /HMGA1) ISH//qRT-PCR//MeRIP//RNA Pull-Down LINC00460 expression was increased in human CRC, and high LINC00460 expression was correlated with poor five-year overall survival and disease-free survival.In addition, LINC00460 enhanced the protein expression of high-mobility group AT-hook 1 (HMGA1) by directly interacting with IGF2BP2 and DHX9 to bind the 3′ untranslated region (UTR) of HMGA1 mRNA and increased the stability of HMGA1 mRNA. In addition, the N6-methyladenosine (m6A) modification of HMGA1 mRNA by METTL3 enhanced HMGA1 expression in CRC. LINC00460 expression was increased in human CRC, and high LINC00460 expression was correlated with poor five-year overall survival and disease-free survival. Yes LINC00460 overexpression sufficiently induced the epithelial–mesenchymal transition and promoted tumor cell proliferation, migration, and invasion in vitro and tumor growth and metastasis in vivo.Finally, it suggested that HMGA1 was essential for LINC00460-induced cell proliferation, migration, and invasion. 33526059 LINC00460 LncRNA Homo sapiens Colonic Neoplasms Interaction[miR-433-3p,ANXA2 ] Western Blot//CCK8//FISH//RIP//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that LINC00460 was expressed highly in CC.Moreover, LINC00460 was able to specifically bind to miR-433-3p to increase the expression of ANXA2. Furthermore, LINC00460 Expression[down-expression]regulated the E-cadherin expression and Expression[Expression[up-expression]-expression]regulated the vimentin and N-cadherin expression by Expression[Expression[up-expression]-expression]regulating ANXA2, therefore inducing epithelial-mesenchymal transition. Yes Expression[down-expression]regulation of LINC00460 inhibited cell invasion and proliferation in vitro and restrained tumor growth in vivo. 32069703 LINC00460 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines Interaction[sponging miR-613] qRT-PCR Our findings revealed that the level of LINC00460 was significantly upregulated in PTC tissues and cell lines.These findings suggested that LINC00460 could function as a competing endogenous RNA to regulate SphK2 expression by sponging miR-613 in PTC. Our findings revealed that the level of LINC00460 was significantly upregulated in PTC tissues and cell lines, which was positively correlated with advanced tumor-node-metastasis (TNM) stage and lymph node metastasis. Yes Cellular experiments exhibited that knockdown of LINC00460 decreased proliferative, migratory, and invasive abilities of PTC cells. 30478856 LINC00460 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell Regulation(PI3K/AKT signaling pathway) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining We identified the significant up-regulated expression of LINC00460 both in RCC tissues and cell. We crucially identified that LNC00460 promotes development of RCC by influencing the PI3K/AKT pathway. Knockdown of LNC00460 decreased the phosphorylation of AKT and mTOR. The key finding of our study showed that LINC00460 functions as an oncogene in RCC pathogenesis by mediating the PI3K/AKT. RCC patients with elevated LINC00460 expression have shorter survival. Yes Up-expression of LINC00460 promoted cell proliferation, invasion and migration, meanwhile down-regulation of LINC00460 exerted inhibitory effect on these activities. 35912013 LINC00460 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[LINC00460 / miR-342-3p / AGR2 axis ] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Transwell Assay LINC00460 was up-regulated in HCC tissues and cell lines compared with the control.The LINC00460 / miR-342-3p / AGR2 axis exerts anti-tumor effect in HCC in vitro and in vivo, consolidating and expanding the research about targeted gene therapy for early diagnosis and treatment of HCC. Yes Then we revealed that knockdown of LINC00460 suppressed cell proliferation and cell mobility and induced cell apoptosis in HCC cells. 32493835 LINC00460 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues and cell lines regulation[miR-342-3p/AGR2 Axis] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We firstly detected LINC00460 expression was significantly upregulated in both HCC tumor tissues and cell lines. LINC00460 promotes HCC progression by elevating AGR2 expression via sponging miR-342-3p, providing a promising therapeutic target for HCC treatment. Yes Functionally, LINC00460 facilitated HCC cell proliferation, migration, and invasion capacities, which due to that LINC00460 could physically bind to and repress miR-342-3p to elevate the expression of AGR2. 32184630 LINC00460 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-503-5p/miR-654-3p and TCP1) qRT-PCR Our results showed that LINC00460 was markedly over-expressed in HCC and silencing LINC00460 impaired cell stemness. In conclusion, LINC00460 aggravated cell stemness in HCC via targeting miR-503-5p/miR-654-3p and TCP1, suggesting that LINC00460 may work as a potential signature for cell stemness in HCC Yes Additionally, LINC00460 knockdown curbed proliferation, migration, invasion and epithelial-to-mesenchymal transition (EMT) and drove apoptosis of HCC cells. 34612153 LINC00460 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC cancer tissues and cell lines Interaction[sponging miR-612 to up-regulate AKT2] Western Blot//CCK8//FISH//RIP//qRT-PCR//Luciferase Report Assay//Transwell Assay In the current study, we discovered that LINC00460 was relatively up-regulated in both HNSCC cancer tissues and cell lines, and predicted a poor prognosis in HNSCC patients.Our results identified miR-612 as a novel target of LINC00460, whose expression suggested a negative correlation with LINC00460 in HNSCC tissues and cell lines. LINC00460 increased the expression of serine/threonine kinase AKT2 via sponging miR-612. Rescue experiments indicated that LINC00460 could promote HNSCC progression partially through inhibition of miR-612. Subcutaneous xenotransplanted tumor model confirmed that interference of LINC00460 suppressed in vivo tumorigenic ability of HNSCC via down-regulation of AKT2. In conclusion, our findings clarified the biologic significance of LINC00460/miR-612/AKT2 axis in HNSCC progression and provided novel evidence that LINC00460 may be a new potential therapeutic target for HNSCC. Yes Gain- and loss-of functional studies established that over-expression of LINC00460 promoted cell proliferation, invasion and migration of HNSCC cells in vitro, while the promotion abilities were suppressed via knockdown of LINC00460. 31737186 LINC00460 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Regulation[miR-1224-5p/FADS1 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Linc00460 was up-regulated in OS tissues and cells.In conclusion, this study recognized linc00460 as a new oncogenic lncRNA in OS and suggests that the linc00460/miR-1224-5p/FADS1 axis might be a potential therapeutic target for OS. High linc00460 expression was positively correlated with distant metastasis and poor overall survival of OS patients. Yes Knockdown of linc00460 suppressed OS cells proliferation and metastasis in vitro. 31419446 LINC00460 LncRNA Homo sapiens Leukemia, Myeloid, Acute serum of patients with AM Interaction(miR-320b/PBX3 axis) qRT-PCR//Western Blot It was found that the expression of LINC00460 was significantly upregulated in the serum of patients with AML and those with CN-AML. LINC00460 was also a decoy of microRNA (miR)‑320b, which can further inhibit the expression of PBX homeobox 3 (PBX3). Furthermore, ROC curve analyses demonstrated that serum LINC00460 could differentiate patients with AML from healthy individuals with an area under the curve of 0.8488 (95% CI, 0.7697?0.9279). The serum LINC00460 expression was also significantly decreased when the patients achieved complete remission. Kaplan‑Meier analysis indicated that patients with high serum LINC00460 expression had a shorter overall survival time compared with the low serum LINC00460 expression group. Yes Knockdown of LINC00460 inhibited viability, while inducing cell cycle arrest and apoptosis in AML cells. 33846790 LINC00460 LncRNA Homo sapiens Esophageal Neoplasms ESCA tissues and cell lines regulation[linc00460/miR-1224-5p] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, we discovered that lncRNA linc00460 was obviously over-expressed in ESCA, both in tissues and cell lines. Our findings suggest that linc00460/miR-1224-5p is a possible clinical target for ESCA. Yes Down-regulation of linc00460 significantly suppressed the metastatic potential (including cell migration and invasion) and EMT of ESCA cells. 32534700 LINC00460 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues interaction[targeting microRNA-503-5p] Flow Cytometry//qRT-PCR//MTT//Tunel LINC00460 levels in CC tissues were higher than tumor-adjacent tissues.Hence, LINC00460 functioned as an oncogene in CC that affected cell proliferation and apoptosis via sponging miR-503-5p. This study provides a novel therapeutic target for CC. Yes LINC00460 silencing suppressed proliferation and promoted apoptosis of CC cells as evidenced by decreased cell viability, inhibited proliferation-related protein and cell cycle protein expressions and G1/S transition, increased apoptotic cells and Hoechst-positive cells, and enhanced apoptosis-related protein expressions. 32740791 LINC00460 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Interaction[miR-30a-3p/Rap1A] RNA Pull-Down//IHC//Western Blot//ISH//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay//IF LIN00460 expression was significantly higher in NPC tissues compared with noncancerous tissues. We further demonstrated that LINC00460 regulated Rap1A expression through competitively binding to miR-30a-3p. Yes In NPC cell lines named C666-1 and 5-8F, LINC00460 overexpression promoted cancer cell migration, invasion and epithelial-mesenchymal transition (EMT), while depletion of LINC00460 exhibited opposite effects.LINC00460 knockdown suppressed NPC metastasis in a xenograft mouse model. 31414345 LINC00460 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells interaction[miR-539] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay LINC00460 expression was markedly up-regulated in PTC tissues and cells compared to their corresponding controls by quantitative real-time PCR (qRT-PCR).These findings indicated that LINC00460 can modulate MMP-9 expression to promote cell proliferation, invasion and apoptosis through targeting miR-539, suggesting act as an oncogenic RNA in PTC and provide a new therapeutic perspective. Yes Meanwhile, LINC00460 knockdown notably inhibited the proliferation capacity, accelerated the apoptosis and down-regulated the invasion-related proteins (MMP-2, MMP-9, ZEB1) expression. 32021436 LINC00460 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues Expression[highly expressed] qRT-PCR The present bioinformatic analysis revealed that LINC00460 was upregulated in PC samples with a prognostic significance. The results of real-time quantitative PCR confirmed that LINC00460 was significantly upregulated in cancer tissues and was associated with poor survival of patients with PC. Yes Further in vitro experiments demonstrated that suppressing LINC00460 using small interfering RNA inhibited viability and colony formation of PC cells. 32724379 LINC00460 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer (PC) cells Interaction(miR-320b/ARF1 axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay A marked increase in the level of long non-coding RNA LINC00460 was reported in PAAD patients, in comparison with the healthy controls.Moreover, miR-320b was targeted straight and its expression was downregulated by LINC00460, whose knockdown led to a reduction in ARF1 expression. Interestingly, miR-320b downregulation partly reversed the effect of LINC00460 knockdown on the proliferation, migration, invasion and apoptosis of SW1990 cells, as well as ARF1expression. Yes . It was found in our study that LINC00460 knockdown inhibited SW1990 cell proliferation, migration and invasion and promoted its apoptosis. 33345740 LINC00460 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells Interaction(miR-503-5p/ANLN positive feedback loop) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//EdU Staining//Transwell Assay LINC00460 was up-regulated in PC tissues and cells. LINC00460 silencing attenuates the development of PC by regulating the miR-503-5p/ANLN axis and exosomal LINC00460-induced M2 macrophage polarization accelerates the migration and invasion of PANC-1 cells, thus LINC00460 may act as a possible therapeutic target for treating PC. Yes LINC00460 knockdown suppressed cell proliferation, migration, and invasion, facilitated cell apoptosis and G0/G1 phase arrest, and inhibited the tumor growth through anti-PD-1 therapy. 36482354 LINC00460 LncRNA Homo sapiens Adenocarcinoma of Lung LC tissues and cell lines Interaction[miR-302c-5p/FOXA1 signal pathway] CCK8//qRT-PCR//RNA Pull-Down//Luciferase Report Assay We observed that LINC00460 was increased in lung adenocarcinoma tissues and cells in comparison to their corresponding controls. Rescue assay confirmed that LINC00460 contributed to lung adenocarcinoma progression by regulating miR-302c-5p/FOXA1 signal pathway. In conclusion, LINC00460 promotes LC progression by competitively binding miR-302c-5p and regulating FOXA1 signal pathway. Our findings reveal that LINC00460 may be a potential prognostic biomarker and a candidate target for LC therapy. Yes In addition, silencing LINC00460 was able to suppress lung adenocarcinoma cell growth in vitro and in vivo. 30359741 LINC00460 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues & cell lines Interaction(miR-149-5p) RIP//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay The results revealed that LINC00460 was significantly enhanced in ccRCC tissues, as well as in ccRCC cell lines. The overexpression of LINC00460 was significantly associated with lymph node metastasis and TNM stage, and lead to poor overall survival. Knockdown of LINC00460 reduces the cell ability of proliferation, migration, and invasion. LINC00460 could sponge to miR-149-5p. Yes Knockdown of LINC00460 reduces the cell ability of proliferation, migration, and invasion. 34429655 LINC00460 LncRNA Homo sapiens bladder carcinoma bladder carcinoma tissues and cell lines regulation[miR-612/FOXK1 Axis] Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay LINC00460 was elevated in bladder carcinoma tissues and cell lines. LINC00460 promoted bladder carcinoma progression via sponging miR-612 to facilitate FOXK1 expression, suggesting that LINC00460 might have the potential of being explored as a therapeutic target for treatment of bladder carcinoma. Yes Overexpression of LINC00460 promoted cell viability, proliferation, invasion, and migration, while silencing of LINC00460 indicated the opposite effect on bladder carcinoma progression. 33027786 LINC00460 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cells Interaction(miR-149-5p ) qRT-PCR//Western Blot In the present study, lncRNA LINC00460 was shown to be upregulated in colorectal cancer tissues, and overexpression of LINC00460 significantly promoted metastasis of colorectal cancer in vitro. Furthermore, miR-149-5p interacted with LINC00460, and they negatively regulated expression of each other. Transfection of miR-149-5p mimics partially counteracted the tumor metastasis-promoting effects induced by LINC00460 overexpression. Finally, overexpression of LINC00460 upregulated the expression levels of biglycan, a target gene of miR-149-5p, which has also been identified as an oncogenic driver in colorectal cancer. Yes In the present study, lncRNA LINC00460 was shown to be upregulated in colorectal cancer tissues, and overexpression of LINC00460 significantly promoted metastasis of colorectal cancer in vitro. 33472555 LINC00460 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue ,cell lines Regulation[miR-939-3p/LIMK2 axial ] RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that LINC00460 was upregulated and closely correlated to clinicopathological features and poor prognosis of patients with CRC.The findings of this study showed that LINC00460 works as an oncogene in CRC and promoted CRC cell metastasis via regulation of miR-939-3p/LIMK2 axial. We found that LINC00460 was upregulated and closely correlated to clinicopathological features and poor prognosis of patients with CRC. Yes Functionally, we elucidated that LINC00460 promoted metastasis in CRC cell lines HT29 and LOVO. 30863183 LINC00460 LncRNA Homo sapiens Skin Neoplasms CSCC tissues and cell lines Interaction(ELAVL1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Invasion Assay//Migration Assay//CCK8//qRT-PCR//RIP//IHC//EdU Staining//Transwell Assay LINC00460 was found to be significantly upregulated in CSCC tissues and cell lines. Mechanistically, LINC00460 binds to embryonic lethal abnormal vision like RNA binding protein 1 (ELAVL1) and enhances its stability by inhibiting the β-transducin repeats-containing protein (β-TrCP)-mediated ubiquitination of ELAVL1. Moreover, the effect of LINC00460 silencing on the proliferation, migration, and invasion of CSCC cells could be reversed by overexpressing ELAVL1. Yes Functionally, LINC00460 knockdown inhibited cell proliferation, migration, and invasion in vitro. Consistent with this, when LINC00460 expression decreased, CSCC tumorigenesis and metastasis in vivo were inhibited. 36513874 LINC00460 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Expression[highly expressed] Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay The expression of LINC00460 was significantly upregulated in CRC tissues and cells, associated with early stage CRC and low disease-free survival. The expression of LINC00460 was significantly upregulated in CRC tissues and cells, associated with early stage CRC and low disease-free survival. Yes The downregulated of LINC00460 expression increased cell proliferation by regulating the cell cycles of SW620 and HCT116 cells. LINC00460 knockdown did not affect cell migration or invasion in vitro. 30123352 LINC00467 LncRNA Homo sapiens Glioma glioma tissues interaction[miRNA-485-5p] qRT-PCR//Luciferase Report Assay LINC00467 was upregulated in glioma. LINC00467 aggravates the progression of glioma by negatively regulating miRNA-485-5p, which may be a potential therapeutic target for glioma. Yes The knockdown of LINC00467 attenuated proliferative and invasive abilities, and induced apoptosis in U87 and U251 cells. 32016980 LINC00467 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Regulation[Linc00467/miR-20b-5p/CCND1 signaling pathway] Western Blot//qPCR//CCK8//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//Colony Formation Assay//EdU Staining Our data suggested that linc00467 expression was elevated in LUAD tissues and correlated with overall survival of LUAD patients. Linc00467/miR-20b-5p/CCND1 signaling pathway may provide new insights into lung cancer treatment. Our data suggested that linc00467 expression was elevated in LUAD tissues and correlated with overall survival of LUAD patients. Yes Linc00467 knockdown resulted in reduced proliferation rate in lung cancer cells. 31686834 LINC00467 LncRNA Homo sapiens Adenocarcinoma of Lung cell lines Regulation[Wnt/β-catenin signaling pathway] ChIP//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay High expression of LINC00467 was further detected in LUAD cell lines. Collectively, we determined that STAT1-induced upregulation of LINC00467 promoted LUAD progression by epigenetically silencing DKK1 to activate Wnt/β-catenin signaling pathway. Yes Functionally, high expression level of LINC00467 promoted LUAD cell proliferation and migration, indicating that LINC00467 exerted oncogenic functions in LUAD progression. 31027730 LINC00467 LncRNA Homo sapiens Prostatic Neoplasms PC tissues and cells Interaction(miR-494-3p/STAT3 Axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Cell Cycle Assay//Transwell Assay We established that LINC00467 expression was upregulated in PC tissues and cells. Western blot analysis showed that LINC00467 could regulate the STAT3 pathway. We established that LINC00467 is mainly localized to the cytoplasm. Bioinformatics analysis and rescue experiments indicated that LINC00467 promotes PC progression via the miR-494-3p/STAT3 axis. Yes Downregulated LINC00467 expression inhibited PC cell growth, cell cycle progression, migration, and invasion. Downregulated LINC00467 expression similarly inhibited PC cell migration via M2 macrophage polarization. Downregulated LINC00467 expression was also able to suppress PC tumor growth in vivo. 34094954 LINC00467 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC cells regulation[ miR-299-5p/ubiquitin specific protease-48 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay LINC00467 was considerably upregulated in HNSCC cells, and an absence of LINC00467 suppressed cell growth, cell migration and the epithelial-mesenchymal process in HNSCC. LINC00467 enhances HNSCC progression by serving as a sponge of miR-299-5p to increase USP48 expression. Yes LINC00467 was considerably upregulated in HNSCC cells, and an absence of LINC00467 suppressed cell growth, cell migration and the epithelial-mesenchymal process in HNSCC. 32159247 LINC00466 LncRNA Homo sapiens Glioma glioma cells and tissues regulation[miR-508/CHEK1] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We report that LINC00466 expression is increased in glioma cells and tissues.LINC00466 may exhibit its anti-oncogenic roles through targeting the miR-508/CHEK1 axis. Clinical studies revealed that the elevated expression of LINC00466 is closely correlated with an advanced World Health Organization grade (p = 0.008), Karnofsky Performance Status score (p = 0.004) and a short overall survival (p = 0.0035) of glioma patients. Yes Functional assays revealed that LINC00466 knockdown distinctly suppresses glioma cell proliferation, migration, invasion and epithelial-mesenchymal progress, and also promotes apoptosis. 33037684 LINC00466 LncRNA Homo sapiens Glioma glioma tissues Interaction(miR-137 /PPP1R14B ) In Vivo Experiment//IHC//Western Blot//Transfection//qRT-PCR//RIP//FISH//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay Highly expressed LINC00466 and PPP1R14B and lowly expressed miR-137 were eventually revealed in glioma tissues. LINC00466 could bind to miR-137, and up-regulation of miR-137 could attenuate the enhancing effects caused by LINC00466 overexpression. We took a further step and found that miR-137 could bind to PPP1R14B. Yes Overexpression of LINC00466 could promote proliferation, metastasis and drug sensitivity to TMZ of glioma cells. 33642868 LINC00461 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Regulation[miR-30a-5p/integrin β3 axis ] qRT-PCR In the current study, LINC00461 was found to be significantly upregulated in both BC tissues and cell lines.Taken together, LINC00461 exerts an oncogenic role in BC through miR-30a-5p/ITGB3 axis. Besides, we found that high LINC00461 expression was associated with TNM stage and differentiation. Yes Furthermore, functional studies demonstrated that LINC00461 expedited BC cell migration and invasion. 30623482 LINC00461 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Interaction[targeting miR-323b-3p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that the expression of LINC00461 was significantly overexpressed in CRC tissues and different cell lines.Downregulation of LINC00461 expression significantly suppressed the proliferation, migration and invasion of CRC cells and promoted cell apoptosis. We found that the expression of LINC00461 was significantly overexpressed in CRC tissues and different cell lines Yes Downregulation of LINC00461 expression significantly suppressed the proliferation, migration and invasion of CRC cells and promoted cell apoptosis. 31908480 LINC00461 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[LINC00461/miR-149-5p/LRIG2 axis ] CCK8//qRT-PCR//RNA Pull-Down//Transwell Assay Here, we found that LINC00461 was upregulated in HCC tissues and positively correlated with advanced stage and metastasis.In summary, our findings revealed that LINC00461 is an oncogene in HCC through regulating miR-149-5p/LRIG2 pathway. Here, we found that LINC00461 was upregulated in HCC tissues and positively correlated with advanced stage and metastasis. Furthermore, LINC00461 overexpression in HCC patients predicts unfavorable prognosis. Yes Loss-of-function assays showed that LINC00461 silencing suppressed the proliferation, migration and invasion of HCC cells in vitro, and impeded tumor growth in vivo. 30879766 LINC00461 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[LINC00461/miR-216a/aquaporin 4 pathway] qRT-PCR LINC00461 was upregulated, and miR-216a was downregulated in glioma tissues and cells, and LINC00461 upregulation was correlated with large tumor size, higher WHO grade and recurrence, and poor overall survival. Moreover, LINC00461 downregulation blocked the glioma tumor growth in vivo. In conclusion, LINC00461 knockdown inhibits glioma cell proliferation, migration, invasion, and TMZ resistance through miR-216a/AQP4 axis, suggesting LINC00461 as an oncogene in glioma progression. LINC00461 was upregulated, and miR-216a was downregulated in glioma tissues and cells, and LINC00461 upregulation was correlated with large tumor size, higher WHO grade and recurrence, and poor overall survival. Yes LINC00461 knockdown suppressed cell viability, abilities of cell cloning and migration and invasion, and TMZ resistance in glioma. 33817241 LINC00461 LncRNA Homo sapiens Multiple Myeloma blood Interaction[microRNA/BCL-2 ] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay LINC00461 was highly expressed in MM. Our findings demonstrate that LINC00461, a sponge for miR-15a/16, is highly expressed in MSC-derived exosomes, and enhances MM cell proliferation, which may become an excellent candidate for therapeutic applications. Yes Knockdown of LINC00461 dramatically reduced MM cell proliferation and induced cell apoptosis. 30409700 LINC00461 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[ miR-518a-3p/WDR1 pathway] qRT-PCR Our results demonstrated that LINC00461 was significantly up-regulated in NSCLC tissues and cell lines.aken together, we suggested an essential role of LINC00461/miR-518a-3p/WDR1 axis in NSCLC, which could be used as a potential therapeutic target for NSCLC treatment. Yes Furthermore, knockdown of LINC00461 inhibited NSCLC cell proliferation and invasion in vitro as well as suppressed tumor growth and metastasis in vivo. 33233986 LINC00461 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL cells Interaction(miR-411-5p/BNIP3 Pathway) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//IHC//Bioinformatics Analysis The level of LINC00461 in DLBCL was significantly higher than that in normal cases, and the level in recurrence DLBCL was significantly higher than that in nonrecurrence. The results shown that miR-411-5p bound to LINC00461 and BNIP3 and was negatively correlated with LINC00461 and BNIP3 mRNA in blood of DLBCL patients.The inhibition of LINC00461 or overexpression of miR-411-5p reduced the expression of BNIP3 protein, thereby inducing apoptosis at the in vivo and in vitro levels. Yes Suppressing the level of LINC00461 inhibited cell proliferation and induced apoptosis. 35783530 LINC00461 LncRNA Mus musculus Myocardial Reperfusion Injury I/R mice Interaction(microRNA-185-3p/Myd88) In Vivo Experiment//RNA Pull-Down//Western Blot//Tunel//qRT-PCR//Luciferase Report Assay//H&E Staining I/R mice showed LINC00461 and Myd88 up-regulation and miR-185-3p down-regulation. Down-regulating LINC00461 or up-regulating miR-185-3p recovered cardiac function, reduced myocardial enzyme levels, and attenuated oxidative stress and cardiomyocyte apoptosis in mice with I/R. miR-185-3p overexpression rescued the promoting effect of LINC00461 upregulation on myocardial injury in I/R mice. Yes Down-regulating LINC00461 or up-regulating miR-185-3p recovered cardiac function, reduced myocardial enzyme levels, and attenuated oxidative stress and cardiomyocyte apoptosis in mice with I/R. miR-185-3p overexpression rescued the promoting effect of LINC00461 upregulation on myocardial injury in I/R mice. 35272621 LINC00460 LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[CCNG2,EZH2/LSD1] RNA Pull-Down//Western Blot//Tunel//Flow Cytometry//qRT-PCR//RIP//MTT//ChIP In this research, we discovered that LINC00460 is remarkably upregulated in GC tissues compared to the non-tumor tissues.In conclusion, our results suggested that LINC00460 acted as an oncogene in GC to inhibit the expression of CCNG2 at least partly by binding with EZH2 and LSD1. Yes Functionally, proliferation of GC cells could be regulated by LINC00460 both in vitro and in vivo. 32059342 LINC00460 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines Regulation[miR-489-5p/FGF7/AKT axis] RNA Pull-Down//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We demonstrated that lncRNA Linc00460 was upregulated in breast cancer, and its expression level was positively associated with lymphatic metastasis and poor overall survival. Linc00460 was identified as a direct target of miR-489-5p, which further targeted FGF7 and exerted oncogenic functions in breast cancer. Mechanistically, Linc00460 served as a competing endogenous RNA of FGF-7 mRNA by sponging miR-489-5p, resulting in upregulated FGF7 expression and AKT activity. Notably, forced expression of miR-489-5p abrogated Linc00460-mediated oncogenic behavior and activation of the FGF7-AKT pathway in breast cancer cells. We demonstrated that lncRNA Linc00460 was upregulated in breast cancer, and its expression level was positively associated with lymphatic metastasis and poor overall survival. Yes Forced expression of Linc00460 increased, whereas Linc00460 silencing decreased, breast cancer cell viability, migration and invasion both in vitro and in vivo. 31308741 LINC00460 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Regulation[LINC00460/miR-485-5p/Raf1 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay LINC00460 was upregulated in PTC tissues and cells. Raf1 was upregulated in PTC tissues, but miR-485-5p was down-regulated.Bioinformatics prediction revealed that LINC00460 had binding sites with miR-485-5p, which was validated by luciferase reporter assay. In addition, miR-485-5p was confirmed to directly target Raf1 3'-UTR. Moreover, LINC00460 promoted PTC progression by sponging miR-485-5p to elevate the expression of Raf1. Knockdown of LINC00460 restrained tumor growth in vivo. High LINC00460 expression was associated with poor prognosis. Yes LINC00460 knockdown suppressed proliferation, migration, invation and EMT of PTC cells. 31870440 LINC00520 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung (NSCLC) tissue and cells Interaction(miR-577/CCNE2 axis) qRT-PCR//ChIP//RIP//Western Blot In this paper, our group first showed that LINC00520 level was elevated in non-small cell lung cancer (NSCLC) tissue and cells. Mechanistically, we found that LINC00520 serving as a competing endogenous RNA to be involved in the modulation of miR-577 expressions, and thus affected the expression of CCNE2 which was a target gene of miR-577. Increased LINC00520 was distinctly correlated with advanced tumor stage and shorter survival time in NSCLC patients. Yes Moreover, in NSCLC cells with si-LINC00520, up regulation of CCNE2 led to an increase of cell growth and invasion. 33728585 LINC00332 LncRNA Homo sapiens Stomach Neoplasms GC tissues Regulation(MMP-13 ) Wound Healing Assay//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Invasion Assay The expressions of LINC00332 and MMP-13 were significantly downregulated and upregulated in GC tissues, respectively. A significant inverse correlation between LINC00332 and MMP-13 mRNA expression was observed in tumor samples. Yes The mRNA expression level of mesenchymal markers, stem cell factors, and MMP genes were significantly decreased after the LINC00332 ectopic expression, while epithelial markers expression was significantly increased. The LINC00332 overexpression markedly repressed proliferation, migration, and invasion and did not induce apoptosis in AGS cells. In addition, LINC00332 overexpression notably promoted the E-cadherin protein expression. 35787995 LINC00324 LncRNA Homo sapiens Colorectal Neoplasms cell lines Interaction[ targeting miR-214-3p] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay We first detected the expression of LIN00324 was increased while miR-214-3p was decreased in CRC cells. Moreover, overexpression of miR-214-3p also inhibited CRC cell proliferation, migration and invasion. Then, we identified miR-214-3p as directly target of LINC00324 and the expression of miR-214-3p was downregulated by LINC00324. In addition, inhibiting miR-214-3p reversed the effects of LINC00324 on CRC cell proliferation, migration and invasion. Yes Knockdown of LIN00324 suppressed proliferation, migration and invasion in SW620 and HCT15 cells. 31858541 LINC00324 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissue and cell lines regulation[ downregulation of TRIM29 via upregulating microRNA-195-5p] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//ChIP Levels of LINC00324 were markedly up-regulated in PTC. In short, this work demonstrates that LINC00324 knockdown inhibits the proliferation and invasion of PTC cells by decreasing TRIM29 expression via up-regulating miR-195-5p expression. Yes Silencing of LINC00324 significantly repressed the proliferation and invasion of PTC cells. 33318312 LINC00324 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction[regulating WDR66] qRT-PCR We first validated the upregulation of LINC00324 in OS tissues and cell lines and established its correlation with OS tumor progression and metastasis.In conclusion, the present study proved that LINC00324 accelerated the proliferation and migration of osteosarcoma cells through regulating WDR66, providing a new prognostic target for osteosarcoma. We first validated the upregulation of LINC00324 in OS tissues and cell lines and established its correlation with OS tumor progression and metastasis. Yes Gain- and loss-of-function assays revealed that LINC00324 accelerated cell proliferation and migration in OS. 31225659 LINC00324 LncRNA Homo sapiens Ovarian Neoplasms IOT tissues and cells interaction[miR-214-5p-CDK6/CCND1/MDM2/MDM4 network] qRT-PCR According to the results, LINC00324 was upregulated in IOT tissues and cells, as determined by reverse transcription?quantitative PCR, and its depletion impaired cell proliferation ability and improved cell apoptosis ability in IOT. Taken together, these results demonstrated that LINC00324 could serve as a competing endogenous RNA to facilitate IOT cell proliferation by regulation of miR‑214‑5p‑CDK6/CCND1/MDM2/MDM4 network, which possibly provide a novel therapeutic target for IOT. Yes According to the results, LINC00324 was upregulated in IOT tissues and cells, as determined by reverse transcription?quantitative PCR, and its depletion impaired cell proliferation ability and improved cell apoptosis ability in IOT. 33416104 LINC00319 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cell lines Regulation[miR-423-5p/NACC1 pathway] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay In this study, LINC00319 expression was found to be upregulated in ovarian cancer tissues and cell lines.In conclusion, our findings demonstrated that LINC00319 promotes ovarian cancer progression through upregulating NACC1 expression by restraining miR-423-5p. Yes Cell Counting Kit-8 (CCK-8), colony formation and transwell assays indicated that LINC00319 upregulation promoted proliferation, migration and invasion of ovarian cancer cells. 30442370 LINC00319 LncRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues Regulation[miR-4492/ROMO1 axis] qRT-PCR In our research, LINC00319 was shown to be an upregulated lncRNA in BCa tissues.In addition, the data indicated LINC00319 was a sponge for miR-4492 and miR-4492 suppressed ROMO1 expression in BCa. Furthermore, our results illustrated miR-4492/ROMO1 axis regulates proliferation, migration, and invasion and LINC00319 exerts oncogenic roles through modulating miR-4492/ROMO1 axis. In sum, this study suggested that LINC00319 acts as oncogenic roles in BCa progression. Yes Silencing of LINC00319 suppressed BCa proliferation and invasiveness. 31608995 LINC00319 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells regulation[miR-199a-5p/FZD4 axis] Western Blot//CCK8//qRT-PCR//FISH//Flow Cytometry//Luciferase Report Assay//Transwell Assay The present study using lncRNA sequencing found LINC00319 to be significantly upregulated in OSCC cells subjected to rCCL18 stimulation. Taken together, these results evidenced a mechanism of CCL18 action in OSCC mediated through the LINC00319/miR-199a-5p/FZD4 signaling pathway, which may comprise a potential target for OSCC therapeutic development. Yes Furthermore, LINC00319 knockdown was found to attenuate the carcinogenic function of CCL18 in OSCC, reducing OSCC proliferation, metastasis, epithelial-mesenchymal transition (EMT), and angiogenesis.Functionally, in vitro and in vivo experiments showed that LINC00319 promoted OSCC growth and metastasis via downregulating miR-199a-5p and upregulating FZD4. 32948745 LINC00319 LncRNA Homo sapiens Osteosarcoma tumor cells and tissue regulation[miR-455-3p/NFIB axis] qRT-PCR//Luciferase Report Assay//FISH PCR results showed that lncRNA LINC00319 exhibited high expression in tumor cells and tissue. lncRNA LINC00319 may promote OS progression by regulating the miR-455-3p/NFIB axis, which probably serves as an innovative potential indicator of prognosis and a target of therapy for OS. Yes Knockdown of lncRNA LINC00319/NFIB or overexpression of miR-455-3p blocked the migration of OS cells. 32621625 LINC00319 LncRNA Homo sapiens Glioma glioma tissues Expression[highly expressed] CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//ChIP In our study, LINC00319 was expressed at high levels in glioma and closely associated with poor prognosis of patients with glioma, whose knockdown impaired cell proliferation, arrested cell cycle and induced cell apoptosis of glioma. In our study, LINC00319 was expressed at high levels in glioma and closely associated with poor prognosis of patients with glioma, whose knockdown impaired cell proliferation, arrested cell cycle and induced cell apoptosis of glioma. Yes In our study, LINC00319 was expressed at high levels in glioma and closely associated with poor prognosis of patients with glioma, whose knockdown impaired cell proliferation, arrested cell cycle and induced cell apoptosis of glioma. 31325436 LINC00319 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Regulation[LINC00319/miR-1207-5p/KLF12 pathway] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//IHC It was indicated that LINC00319 was markedly increased in NPC tissues and cells in comparison to their corresponding controls. Taken together, our study discovered the oncogenic role of LINC00319 in clinical specimens and cellular experiments, showing the potential LINC00319/miR-1207-5p/KLF12 pathway. Yes Silence of LINC00319 was able to suppress NPC cell growth in vitro while overexpression of LINC00319 inversed this process. 30243935 LINC00313 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung H1299-derived exosomes Interaction(miR-135a-3p /STAT6) qRT-PCR//Luciferase Report Assay//Western Blot LINC00313 was overexpressed in H1299-derived exosomes, and its knockdown abolished the effect of H1299-induced M2 macrophage differentiation. LINC00313 sponged miR-135a-3p to increase the STAT6 expression, resulting in the M2 macrophage differentiation. Yes LINC00313 was overexpressed in H1299-derived exosomes, and its knockdown abolished the effect of H1299-induced M2 macrophage differentiation. LINC00313 sponged miR-135a-3p to increase the STAT6 expression, resulting in the M2 macrophage differentiation. 35980503 LINC00313 LncRNA Homo sapiens Osteosarcoma OS tissues and cells regulation[miR-342-3p/FOSL2 axis] RNA Pull-Down//Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay LINC00313 was upregulated and miR-342-3p was downregulated in OS tissues and cells. LINC00313 is upregulated in OS, and LINC00313 knockdown plays a vital anti-tumor role in OS cell progression through a miR-342-3p/FOSL2 axis. High expression of LINC00313 was associated with shorter overall survival. Yes LINC00313 knockdown suppressed tumor growth in vivo. 32390359 LINC00313 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical carcinoma tissues and cells Interaction(miR-4677-3p/CDK6 Axis) In Vivo Experiment//Western Blot//Transwell Assay//Wound Healing Assay//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//IF Our data showed that the levels of LINC00313 in cervical carcinoma tissues and cells were significantly up-regulated. Luciferase reporter assay confirmed that miR-4677-3p/CDK6 regulatory axis is the direct downstream of LINC00313. Functional gain- and loss-of-function strategies further showed that LINC00313 induced the up-regulation of CDK6 expression through competitive binding with miR-4677-3p, leading to promote the progression of cervical carcinoma. Yes Functionally, LINC00313 accelerated the progression, migration, and EMT of SiHa and Hela cells. 33824592 LINC00312 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Regulation[miR‑9/CDH1 axis] qRT-PCR In the present study, LINC00312 was found to be downregulated in human BC tissues and cell lines by RT‑qPCR. Mechanistically, LINC00312 was found to induce suppression of cell migration and invasion by directly binding to miR‑9. Overexpression of LINC00312 increased the expression of cadherin 1 (CDH1), a direct target of miR‑9, and decreased the expression of vimentin (VIM), a major cytoskeletal component of mesenchymal cells as determined by western blot analysis. miR‑9 partly abrogated the upregulation of CDH1 and downregulation of VIM induced by LINC00312. Taken together, the results of the present study indicate a role for the LINC00312/miR‑9/CDH1 axis in the progression of BC, and suggest a novel lncRNA‑based diagnostic biomarker or therapeutic target for BC. Yes The findings of a functional study indicated that overexpression of LINC00312 suppressed the proliferation, colony forming ability, migration and invasiveness of BC cell lines. 31894332 LINC00312 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell Regulation[LINC00312-miR-21-PTEN axis ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Here, we found that LINC00312 is underexpressed in CRC tissues and cell lines. Taken together, our results elucidate the role of the LINC00312-miR-21-PTEN axis in CRC cell proliferation and tumour progression and may lead to new lncRNA-based diagnostics or therapeutics for CRC. Yes Functional experiments suggested that LINC00312 suppresses growth, migration and invasion of CRC cells in vitro and attenuates tumour proliferation and metastasis in vivo. 30134003 LINC00312 LncRNA Homo sapiens Thyroid Neoplasms TC tissues and cell lines Regulation[ PI3K/Akt signaling pathway] CCK8//qRT-PCR//EdU Staining//Transwell Assay The expression of LINC00312 was significantly decreased in TC tissues and cell lines.LINC00312 can act as a tumor-suppressor in TC by attenuating the PI3K/Akt signaling pathway, and LINC00312 could be a novel diagnosis biomarker and a promising therapeutic target for TC patients. Yes In an in vitro experiment, si-LINC00312 significantly promoted the invasion and proliferation of TC cells. Conversely, overexpression of LINC00312 decreased cell proliferation and invasion in vitro, and decreased tumorigenicity in TC xenograft models in nude mice. 29969438 LINC00304 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues,cell lines Interaction[regulating CCNA1] qRT-PCR//Microarray We observed higher expression of LINC00304 in PCa cells and samples compared with normal prostate cells and tissues. Further, we identified androgen-inhibited lncRNA, LINC00304 as a direct target of AR. A series of functional studies revealed that overexpression of LINC00304 could significantly promote cell proliferation and cell cycle progression in PCa cells. We also find that LINC00304 can significantly promote CCNA1 expression in PCa cells. Yes Functional analysis of LINC00304 showed it was related to regulating cell cycle process, cellular developmental process, and focal adhesion. 31012142 LINC00301 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC clinical specimens or cell lines regulation[FOXC1/LINC00301/EZH2/EAF2/pVHL/HIF1α and FOXC1/LINC00301/miR-1276/HIF1α pathways] RNA Pull-Down//qRT-PCR//RIP//FISH//ChIP LINC00301 is highly expressed in NSCLC and closely corelated to its prognosis by analyzing the relationship between differentially expressed lncRNAs and prognosis in NSCLC samples. In summary, our present research revealed the oncogenic roles of LINC00301 in clinical specimens as well as cellular and animal experiments, illustrating the potential roles and mechanisms of the FOXC1/LINC00301/EZH2/EAF2/pVHL/HIF1α and FOXC1/LINC00301/miR-1276/HIF1α pathways, which provides novel insights and potential theraputic targets to NSCLC. Yes in vitro and in vivo experiments revealed that LINC00301 facilitates cell proliferation, releases NSCLC cell cycle arrest, promotes cell migration and invasion, and suppresses cell apoptosis in NSCLC. 32878637 LINC00299 LncRNA Homo sapiens Atherosclerosis atherosclerotic plaques,blood Regulation[Linc00299/miR-490-3p/AURKA axis ] RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//migration assay//Cell Apoptosis Assay Expressions of Linc00299 and miR-490-3p were upregulated and downregulated in atherosclerosis patients, respectively.Our study reveals an important effect of Linc00299/miR-490-3p/AURKA axis on regulating cell proliferation and migration in atherosclerosis. Yes Both Linc00299 knockdown and miR-490-3p overexpression suppressed cell proliferation, increased apoptosis and inhibited migration of VSMCs and HUVECs. 30734057 LINC00324 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue regulation[miR-139-5p/IGF1R axis] qRT-PCR//MTT//Transwell Assay//Western Blot In NSCLC, the high expression of LINC00324 had correlation with the poor prognosis.Highly expressed LINC00324 in NSCLC through sponged miR-139-5p to elevate IGF1R expression and promoted cell proliferation and invasion. This research demonstrated that LINC00324 is a potential NSCLC diagnosis and therapy target. In NSCLC, the high expression of LINC00324 had correlation with the poor prognosis. Yes LINC00324 promoted the proliferation and invasion of NSCLC cells while miR-139-5p inhibited these behaviors. 32734536 LINC00339 LncRNA Homo sapiens Triple Negative Breast Neoplasms cell lines Regulation[miR-377-3p/HOXC6 signaling pathway] Western Blot//qPCR//Flow Cytometry//RIP//MTT//Luciferase Report Assay Linc00339 was increased in breast cancer cell lines compared with the normal epithelial cell.In conclusion, our results illuminated that the novel Linc00339/miR-377-3p/HOXC6 axis played a critical role in TNBC progression and might be a promising therapeutic target for TNBC treatment. Yes Through in vitro and in vivo experiments, Linc00339 overexpression promoted triple-negative breast cancer (TNBC) proliferation, inhibited cell cycle arrest, and suppressed apoptosis. Silencing of Linc00339 obtained the opposite effects. 30618083 LINC00459 LncRNA Homo sapiens Melanoma melanoma cell lines and tissues Interaction[sponging miR-218 to elevate DKK3] qRT-PCR//Luciferase Report Assay//RNA Pull-Down The results demonstrated decreased LINC00459 in melanoma cell lines and tissues.In conclusion, our analysis suggested that the LINC00459 could sponge miR-218 and increase the expression of DKK3 gene, thus inhibiting the invasion and proliferation of melanoma cells, which indicated that the LINC00459 could be an effective biomarker for melanoma and its potential as the therapeutic target. Yes According to the in-vitro and in-vivo experiments, up-regulated LINC00459 had inhibitory effect on cell proliferation and invasion. 31844121 LINC00339 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Interaction[miR-148a-3p/ROCK1 axes] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay LINC00339 was overexpressed in ovarian cancer tissues, showed a poor prognosis in patients with ovarian cancer, and correlated with tumor size and advanced clinical stages. LINC00339 regulated ovarian cancer cell proliferation, migration, and invasion by targeting miR-148a-3p/ROCK1 axes, which provided novel insights for ovarian cancer diagnosis and therapy. LINC00339 was overexpressed in ovarian cancer tissues, showed a poor prognosis in patients with ovarian cancer, and correlated with tumor size and advanced clinical stages. Yes Upregulation of LINC00339 promoted cell proliferation, migration, and invasion, while downregulation of LINC00339 exhibited an opposite effect. LINC00339 promotedin vivo tumor growth. 31550677 LINC00452 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer cells and tumor tissues interaction[ sponging miR-501-3p] Co-IP//qRT-PCR//RIP//MTT//Luciferase Report Assay//Microarray//Colony Formation Assay//Transwell Assay This study identified a novel lncRNA LINC00452 being elevated in both ovarian cancer cells and tumor tissues in patients. Irrespective of its miRNA sponge function, LINC00452 is capable of preventing ROCK1 protein from ubiquitin/proteasome-mediated degradation via their mutual physical interaction. Such aberrant expression of LINC00452 was negatively correlated with relapse-free survival of ovarian cancer patients. Yes Overexpression of LINC00452 potentiated CaOV3 cell viability, migration and invasion in vitro as well as xenograft tumor growth in vivo. 33168781 LINC00449 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Expression[highly expressed] qRT-PCR Among these, two lincRNAs (LINC01270 and LINC00449) were significantly associated with both worse overall survival and DFS and were expressed at significantly higher levels in tumor tissues compared with adjacent normal breast tissues (log2[Fold Change] > 0.5 and FDR < 0.05). Yes We further evaluated the potential functions of LINC01270 and LINC00449 using in vitro functional experiments and found that siRNA-mediated knockdown of LINC01270 and LINC00449 expression significantly decreased cell viability, colony formation and cell migration ability in TNBC cells (P < 0.05). 33247132 LINC00423 LncRNA Homo sapiens Retroperitoneal liposarcoma RLS tissues Regulation[MAPK signaling pathway] RNA Pull-Down//Flow Cytometry//qRT-PCR//RIP//Colony Formation Assay//IF We found that long intergenic noncoding RNA 423 (linc00423) was downregulated in RLS tissues.Summing up, our findings demonstrated that linc00423 acted as the tumor suppressor in RLS cells through regulating the protein level of NFATC3 at a post-transcriptional level and negatively regulated the MAPK signaling pathway at a transcriptional level. Yes Gain-of-function assays revealed that overexpressed linc00423 obviously inhibited RLS cell growth in vitro and in vivo. 31160581 LINC00365 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[ NF-κB signaling] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining lncRNA LINC00365, which is expressed at a low level in breast cancer. Secretoglobin family 2A member 1 (SCGB2A1) was identified as a potential target protein regulated by LINC00365. The results of the present study demonstrated that the overexpression of LINC00365 and SCGB2A1 inhibited cell viability and induced cell apoptosis through the inhibition of the NF-κB signaling pathway in breast cancer cells. Yes The results of the present study demonstrated that the overexpression of LINC00365 and SCGB2A1 inhibited cell viability and induced cell apoptosis through the inhibition of the NF-κB signaling pathway in breast cancer cells. 31897191 LINC00365 LncRNA Homo sapiens Adenocarcinoma of Lung LAD patients and cells Interaction(miR-429/KCTD12 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining LINC00365 was low expressed in the LAD patients and cells, associating with poor outcome. LINC00365 inhibited KCTD12 expression by sponging miR-429. miR-429 up-regulation and KCTD12 down-regulation partial reversed LINC00365 inhibition on H1975 cells malignant phenotype. Thus, LINC00365 inhibited LAD progression and glycolysis via targeting miR-429/KCTD12 axis. LINC00365 might be a potential candidate for LAD target treatment clinically. LINC00365 was low expressed in the LAD patients and cells, associating with poor outcome. Yes LINC00365 up-regulation attenuated H1975 cells proliferation, migration, invasion, glycolysis and in vivo growth. 35426242 LINC00356 LncRNA Homo sapiens Carcinoma, Hepatocellular regulation[CDK1/CCNB1 Axis] qRT-PCR//Luciferase Report Assay//RIP The results showed that LINC00356, CDK1 and CCNB1 were highly expressed in HCC, while miR-199a-3p was lowly expressed.These results proved that LINC00346 could regulate the expression of CDK1/CCNB1 through the competitive adsorption of miR-199a-3p, thereby affecting the p53 signaling pathway and finally regulating the apoptosis, invasion and cell cycle of HCC cells. Yes Overexpressing LINC00460 and silencing miR-199a-3p promoted cell invasion, inhibited apoptosis of HCC, and arrested the cell cycle in S phase while opposite results were obtained when silencing LINC00346, CDK1, and CCNB1. LINC00346 indirectly affects liver cancer by promoting the expression of CDK1/CCNB1 through competitive adsorption of miR-199a-3p. 32133348 LINC00355 LncRNA Homo sapiens Stomach Neoplasms cell lines,tissues regulation[P53] Wound Healing Assay//CCK8//qRT-PCR//FISH//RNA-seq//IP//Transwell Assay The results showed that LINC00355 was significantly increased in gastric cancer cell lines and patient tissues and closely correlated with late stages, distant metastasis, and poor prognosis of patients. These results indicated that LINC00355 induces gastric cancer cell proliferation and invasion by promoting transcription of RAD18 and UBE3C, which mediates ubiquitination of P53 and thereby plays a critical role in survival and tumorigenicity of gastric cancer cells. The results showed that LINC00355 was significantly increased in gastric cancer cell lines and patient tissues and closely correlated with late stages, distant metastasis, and poor prognosis of patients. Yes High expression of LINC00355 promoted the proliferation and invasion of gastric cancer cells in vivo and in vitro. 33083020 LINC00355 LncRNA Homo sapiens Colonic Neoplasms cell line regulation[ GTF2B/IGFBP2 axis] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay LncRNA LINC00355 was highly expressed in colon cancer cells. In summary, downregulation of lncRNA LINC00355 in colon cancer inhibited tumor growth in colon cancer through effects on the GTF2B/IGFBP2 axis. Yes LncRNA LINC00355 was highly expressed in colon cancer cells, and overexpression of lncRNA LINC00355 increased the expression of IGFBP2 and GTF2B, and thereby promoted the proliferation, chemotaxis, invasion, and migration in colon cancer. 33227664 LINC00355 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[ MiR-6777-3p/Wnt10b axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay The present study revealed that LINC00355:8 was significantly upregulated in HCC, promoted HCC cell proliferation, migration and invasion in vitro and enhanced tumour growth in vivo. Our findings indicate that LINC00355:8 activates Wnt10b and promotes HCC progression via the suppression of miR-6777-3p, which may provide novel therapeutic targets for HCC. Yes The present study revealed that LINC00355:8 was significantly upregulated in HCC, promoted HCC cell proliferation, migration and invasion in vitro and enhanced tumour growth in vivo. 32913459 LINC00355 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer patients and cells Interaction(miR-424-5p/HMGA2 axis) qRT-PCR//RNA Pull-Down LINC00355 was upregulated in bladder cancer patients, especially in patients with higher TNM stage. . Furthermore, LINC00355 could regulate HMGA2 expression by acting as a sponge for miR-424-5p. Overexpression of HMGA2 induced EMT of bladder cancer cells. Additionally, LINC00355 regulated the migration, invasion, and EMT ability of bladder cancer cells through modulating HMGA2 expression via sponging miR-424-5p. LINC00355 was upregulated in bladder cancer patients, especially in patients with higher TNM stage. Elevated LINC00355 was correlated with the poor prognosis of bladder cancer patients. Yes Besides, overexpressed LINC00355 promoted migration, invasion, and epithelial-mesenchymal transition (EMT) ability of bladder cancer cells. Contrarily, decreased LINC00355 suppressed migration, invasion, and EMT ability of bladder cancer cells, and lung metastasis of xenograft tumors. 34641698 LINC00355 LncRNA Homo sapiens Glioma glioma cell lines and specimens Interaction(miR-1225/FNDC3B) Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay LINC00355 expression was increased in glioma cell lines and specimens, and higher LINC00355 expression predicted advanced clinical progress and reduced overall survival and disease-free survival in glioma patients. Mechanistic assays revealed that LINC00355 as a sponge for miR-1225 repressed fibronectin type III domain-containing 3B (FNDC3B) expressions. Yes Functionally, LINC00355 depletion promoted cell proliferation, invasion, and migration in glioma cells and induced apoptosis of glioma cells, whereas LINC00355 upregulation resulted in the opposite effects in vitro. 34603558 LINC00355 LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues and cell lines Interaction[down-regulating miR-195 and up-regulating the expression of CCNE1] Other Initially, we uncovered increased LINC00355 expressions in lung adenocarcinoma tissues and cells. Moreover, silencing LINC00355 by shRNA inhibited the cyclin E1 (CCNE1) gene expression via miR-195 in lung adenocarcinoma cells. Collectively, this study demonstrates the novel lncRNA LINC00355 in regulatory network of CCNE1 via miR-195 in lung adenocarcinoma, highlighting LINC00355 as a new target for the treatment of lung adenocarcinoma. Yes Functionally, our findings demonstrated that LINC00355 silencing suppressed the proliferation in vitro and in vivo. Simultaneously, silencing LINC00355 by shRNA resulted in suppressed proliferation, colony formation and promoted cell cycle arrest and apoptosis via miR-195. 31689506 LINC00342 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-545-5p/CNPY2 axis) In Vivo Experiment//IHC//Western Blot//ISH//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//IF LINC00342 was significantly upregulated in GC tissues and cell lines. Functional experiments showed that LINC00342 regulated the expression of canopy fibroblast growth factor signaling regulator 2 (CNPY2) by competitively sponging miR-545-5p. Yes Silencing of LINC00342 efficiently inhibited proliferation, migration and invasion of AGS cells in vitro, and also suppressed the tumorigenesis of GC in vivo. 34715819 LINC00342 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[targeting miR-203a-3p] qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of LINC00342 was increased in NSCLC tissues and cells compared with normal tissues and cells. Briefly, LINC00342 contributes to NSCLC cells growth and metastasis via targeting miR-203a-3p competitively. Yes Knockdown of LINC00342 suppressed cell proliferation, colony formation, migration, and invasion. 31539128 LINC00342 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-19a-3p/NPEPL1 axis) qRT-PCR//Western Blot LINC00342 was highly expressed in CRC. Mechanistic investigation revealed that LINC00342 might sponge miR-19a-3p to regulate NPEPL1 expression. Further investigation indicated that the ontogenesis facilitated by LINC00342 was inhibited due to the depletion of NPEPL1. Yes Down-regulation of LINC00342 inhibited cell proliferation and metastasis of CRC cells. Moreover, knocking down LINC00342 inhibited the tumor growth in vivo. 33588834 LINC00342 LncRNA Homo sapiens Adenocarcinoma of Lung A549 cells & lung cancer cell lines Interaction(miR-15b/TPBG) Luciferase Report Assay//Bioinformatics Analysis LINC00342 was found to be up-regulated in lung adenocarcinoma. The high expression of LINC00342 was also validated in lung cancer cell lines. LINC00342 induced invasion and epithelial-mesenchymal transition (EMT) process of A549 cells. By analyzing GEO datasets, TPBG was confirmed positively correlated to LINC00342 and highly expressed in lung adenocarcinoma. In addition, TPBG induced invasion and EMT process of A549 cells. Through bioinformatics analysis and luciferase assay, miR-15b was validated as a direct target of both LINC00342 and TPBG. Ectopic miR-15 expression repressed LINC00342 and TPBG. Interestingly, LINC00342 overexpression inhibited miR-15b and induced TPBG, whereas ectopic TPBG unchanged LINC00342 and miR-15b levels. In conclusion, LINC00342 promotes metastasis of lung adenocarcinoma through inducing TPBG targeted by miR-15b. Yes Interestingly, LINC00342 overexpression inhibited miR-15b and induced TPBG, whereas ectopic TPBG unchanged LINC00342 and miR-15b levels. 35452205 LINC00342 LncRNA Homo sapiens Carcinoma, Renal Cell Eleven pairs of cancer tissues and adjacent normal tissues and ccRCC cells Expression [highly expressed] qRT-PCR//Wound Healing Assay//Migration Assay Clinical samples validated expression levels of three-glycolysis-related lncRNAs, and LINC00342 demonstrated the most significant aberrant expression. in vitro, the general overexpression of LINC00342 was detected in ccRCC cells. Yes After silencing LINC00342, the aberrant glycolytic levels and migration abilities in 786-O cells were decreased significantly, which might be explained by suppressed Wnt/β-catenin signaling pathway and reversed Epithelial mesenchymal transformation (EMT) process. 35083240 LINC00339 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Interaction[downregulating miR-218] qRT-PCR//MTT LINC00339 expression was significantly increased in colorectal cancer tissues compared with adjacent colorectal tissues (4.69±1.52 vs 1.02±0.38, P<0.05). LINC00339 expression was negatively correlated with miR-218 expression in colorectal cancer tissues (P<0.05). miR-218 mimics remarkably suppressed the fluorescence intensity of wild-type LINC00339 plasmid (P=0.001), but did not affect the fluorescence intensity of the mutant ones(P=0.88). Compared with cells transfected with LINC00339 siRNA only, downregulation of miR-218 elevated proliferation and decreased apoptosis of LoVoand HCT116 cells. LINC00339 expression was not related to the age and gender of patients (P>0.05), but was associated with TNM stage, lymphatic metastasis, tumor maximum diameters, and differentiation degree (all P<0.05). Yes Knockdown of LINC00339 remarkably inhibited proliferation, but promoted apoptosis of LoVo and HCT116 cells (all P<0.05). 31269584 LINC00339 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[miR-1182/SKA1 pathway] ISH//qRT-PCR//CCK8//Transwell Assay LINC00339 overexpression was correlated with an advanced stage, metastasis, and bad prognosis in HCC patients.Mechanistically, LINC00339 could interact with miR-1182 to promote SKA1 expression. We also demonstrated that SKA1 acted as an oncogene and SKA1 upregulation reversed the effect of LINC00339 silencing. Yes Functional investigation showed that LINC00339 knockdown significantly suppressed HCC cell proliferation, migration, and invasion. Moreover, decreased LINC00339 expression inhibited HCC growth in vivo. 31239716 LINC00467 LncRNA Homo sapiens Glioma tumor samples regulation[p53 ,DNMT1] CCK8//qRT-PCR//Flow Cytometry//RIP//EdU Staining//Transwell Assay The expression of LINC00467 was significantly up-regulated in tumor samples than that in normal samples, which was not correlated with patient survival time.These results indicated that high expression of LINC00467 could promote proliferative and invasive abilities of glioma cells through targeting inhibition of p53 expression by binding to DNMT1. The expression of LINC00467 was significantly up-regulated in tumor samples than that in normal samples, which was not correlated with patient survival time. Yes Upregulation of LINC00467 promoted proliferative and invasive abilities, and accelerated cell cycle in G0/G1 phase of U87 and LN229 cells. 32226508 LINC00467 LncRNA Homo sapiens Glioma cell lines regulation[E2F3,miR-200a] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay LINC00467 was up-regulated in glioma cells. INC00467 promoted the development of glioma by inhibiting miR-200a and promoting E2F3 expression. Yes Knockdown of LINC00467 inhibited the viability, migration and invasion of glioma cells. 32684096 LINC00467 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML specimens and cell lines Interaction(miR-339/SKI pathway) qRT-PCR//Western Blot we find that LINC00467 expression is significantly increased in AML specimens and cell lines. Interestingly, microRNA-339 (miR-339) is upregulated and its target gene SKI, an oncogene, is downregulated in AML cells after LINC00467 knockdown. More importantly, inhibition of miR-339 can largely abolish the effect of LINC00467 knockdown on AML cells. Yes  Further investigations show that knockdown of LINC00467 inhibits the malignant phenotypes of AML cells. Consistently, LINC00467 knockdown slows AML progression in immunodeficient mice. 33054480 LINC00511 LncRNA Homo sapiens Osteoarthritis cell lines regulation[LINC00511/miR-150-5p/SP1] qRT-PCR Functionally, the functional experiments found that LINC00511 expression was upregulated in the IL-1β-stimulated chondrocyte (ATDC5). In conclusion, our findings highlight the function and prognostic value of LINC00511/miR-150-5p/SP1 feedback loop in OA and extend the importance of lncRNA epigenetics in OA biology. Yes Knockdown of LINC00511 facilitated proliferation, and repressed the apoptosis and extracellular matrix (ECM) synthesis of chondrocyte. 32635763 LINC00511 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction[sponging miR-618 ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LINC00511 overexpression was observed in OS tissues and cell lines.LINC00511 was confirmed to be beneficial for osteosarcoma development via sponging miR-618 and increasing MAEL expression and may thus be considered a potential target for osteosarcoma therapy. Yes Knockdown of LINC00511 in nude mice inhibited the tumorigenic ability of OS cells.Transfection-induced overexpression of LINC00511 and MAEL, as well as downregulation, highlighted the features of tumor cells, and LINC00511 overexpression reduced apoptosis in vitro. 31386627 LINC00511 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues regulation[miR-185-3p/E2F1 Axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay It is significantly higher in the clinical samples of osteosarcoma patients than in normal adjacent cancer tissues. The dual-luciferase reporter assay verified the direct interaction between miR-185-3p and LINC00511 or E2F1. The present study shows the higher expression levels of LINC00511 correlates to a shorter overall survival and disease-free survival time in patients with sarcoma. Yes The results showed that the LINC00511 knockdown significantly suppressed osteosarcoma cell growth and metastasis. 32964019 LINC00511 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC cell lines and patient specimens Interaction(miR-29b-3p/VEGFA) qRT-PCR//Western Blot//FISH The aberrant up-regulation of linc00511 was detected in PDAC cell lines and patient specimens compared with controls. Mechanistically, linc00511 could up-regulate VEGFA via its competing endogenous RNA (ceRNA) activity on hsa-miR-29b-3p. In summary, our results define an important axis controlling proliferation, invasion and tumour angiogenesis in PDAC. An increase in linc00511 expression indicates the adverse clinical pathological characteristics and poor prognosis. Yes Functionally, linc00511 depletion in PDAC cells decreased proliferation, migration, invasion and endothelial tube formation. 28984028 LINC00511 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Expression[highly expressed] qRT-PCR In our study, we found LINC00511 expression levels were increased in cervical cancer tissues and cell lines compared with adjacent normal tissues and normal cervical epithelial cell line, respectively. High LINC00511 expression was correlated with advanced clinical stage, large tumor size, histological type of adenocarcinoma, and present lymph node metastasis, distant metastasis, and poor overall survival in cervical cancer patients. Yes The in vitro studies indicated that knockdown of LINC00511 inhibited cervical cancer cell proliferation, migration, and invasion. In conclusion, LINC00511 acts as oncogenic lncRNA in cervical cancer, and may be a novel biomarker and potential therapeutic target for cervical cancer patients. 31434692 LINC00511 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissue,cell lines regulation[miR-324-5p/DRAM1 Axis] Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay Herein, the results showed that LINC00511 was significantly up-regulated in cervical cancer and cell lines and mainly distributed in the cytoplasm of cervical cancer cells. Collectively, these results suggest that LINC00511 functions as a competing endogenous RNA (ceRNA) to regulate the miR-324-5p/DRAM1 axis, leading to HPV-negative and HPV-positive cervical cancer aggravation. Yes Loss-of-function experiments indicated that silencing of LINC00511 inhibited the proliferation and invasion of both HPV-negative and HPV-positive cervical cancer cells, as well as promoted apoptosis by regulating the Bcl-2/Bax axis and Caspase 3 activation. 33116605 LINC00511 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells regulation[RXRA-regulated PLD1] qRT-PCR LINC00511 and PLD1 expressions were remarkably high in cervical cancer tissues and cells.Collectively, this study suggests that LINC00511 acts as an oncogenic lncRNA in cervical cancer via the promotion of transcription factor RXRA-regulated PLD1. Yes Si-LINC00511, si-RXRA or si-PLD1 triggered repression of proliferation and promotion of autophagy and apoptosis of cervical cancer cells. In vivo experiment, si-LINC00511, or si-PLD1 inhibited the tumorigenic ability of nude mice. 32067228 LINC00511 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction(miR-497-5p/MAPK1 axis) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//BrdU//Transwell Assay Up-regulation of LINC00511 expression in CC tissues and cell lines was observed, which was in association with tumor size, clinical stage and lymph node metastasis of the patients. Mechanistically, LINC00511 was capable of targeting miR-497-5p and up-regulating MAPK1 expression. Up-regulation of LINC00511 expression in CC tissues and cell lines was observed, which was in association with tumor size, clinical stage and lymph node metastasis of the patients. Yes LINC00511 overexpression facilitated the proliferation, migration and invasion of CC cells, while opposite effects were observed after knockdown of LINC00511. 36103025 LINC00511 LncRNA Homo sapiens Adenocarcinoma of Lung LAC tissues and cell lines (H1299 and A549) regulation[ LINC00511/miR-625-5p/PKM2 ] CCK8//qRT-PCR//Transwell Assay Data from our study demonstrated that LINC00511 expression was increased in LAC tissues and cells in comparison to their corresponding controls.The present study showed that LINC00511 was involved in LAC progression by targeting miR-625-5p/PKM2, indicating that LINC00511/miR-625-5p/PKM2 may function as promising therapeutic targets for LAC. Moreover, overexpression of LINC00511 indicated the poor prognosis of LAC patients. Yes Overexpression of LINC00511 promoted proliferation, invasion and migration capacities of LAC cells. 32716147 LINC00511 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines Interaction(miR-195-5p/GCNT3 ) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU//Transwell Assay LINC00511 and GCNT3 were found to be upregulated in LUAD, while miR-195-5p was downregulated. Interference with miR-195-5p promoted malignant proliferation of cancer cells. miR-195-5p expression was affected by LINC00511and targeted GCNT3. Yes Silencing LINC00511 or GCNT3 decreased the proliferation, migration, invasion, and Bcl-2 protein content in LUAD cells and increased the expression of Bax. 35399076 LINC00511 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(miR-126-5p/miR-218-5p) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay In the present work, we observed that Linc00511 was upregulated in LUAD tissues and cells.In addition, we determined that Linc00511 promoted COL1A1-mediated cell proliferation and cell motility by sponging miR-126-5p and miR-218-5p. Moreover, Linc00511 activated the PI3K/AKT signaling pathway through upregulation of COL1A1. Yes Loss/gain-of-function experiments indicated that knockdown of Linc00511 significantly inhibited LUAD cell proliferation, migration and invasion and promoted LUAD cell apoptosis, whereas overexpression of Linc00511 showed the opposite effects. Finally, silencing of Linc00511 inhibited LUAD tumor growth in vivo. 35842617 LINC00511 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(miR-4739/PYCR1 ) RNA Pull-Down//Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//BrdU//Transwell Assay The expression levels of LINC00511 and PYCR1 in LUAD were downregulated, whereas that of miR-4739 was upregulated. On the contrary, knockdown of miR-4739 had tumor-promoting effects. Mechanistically, LINC00511 prevented the miR-4739 led inhibition of PYCR1, resulting in PYCR1 overexpression. Yes Functional studies showed that knockdown of LINC00511 or PYCR1 suppressed the proliferation and migration of LUAD cells, and promoted apoptosis. 36371775 LINC00511 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Serum, NSCLC cell Interaction(miR-98-5p/TGFBR1) CCK8//qRT-PCR//RNA Pull-Down//Western Blot Serum Linc00511 level at admission was higher in patients than in healthy controls and decreased on the day of discharge than before surgical resection.During the 3-years of follow-up, plasma Linc00511 level was upregulated only in patients with distant recurrence.Linc00511 was predicted to interact with miR-98-5p, and Linc00511 overexpression inhibited miR-98-5p expression but upregulated TGFBR1, a downstream target for miR-98-5p. Yes Moreover, the elevation of Linc00511 and TGFBR1 both promoted NSCLC cell proliferation, invasion, and migration. However, miR-98-5p overexpression had opposite effects, reversing the effects of TGFBR1. 35993940 LINC00511 LncRNA Homo sapiens Melanoma melanoma cells Interaction(miR-625-5p/PKM2 axis) qRT-PCR Functional analysis of two SFPQ-enriched lncRNA, LINC00511 and LINC01234, demonstrated that these genes independently contribute to the melanoma phenotype and a more detailed analysis of LINC00511 indicated that this occurs in part via modulation of the miR-625-5p/PKM2 axis. Yes Functional analysis of two SFPQ-enriched lncRNA, LINC00511 and LINC01234, demonstrated that these genes independently contribute to the melanoma phenotype and a more detailed analysis of LINC00511 indicated that this occurs in part via modulation of the miR-625-5p/PKM2 axis. 34218270 LINC00511 LncRNA Homo sapiens lung squamous cell carcinoma regulation[miR-150-5p,TADA1] qRT-PCR//Luciferase Report Assay//RIP//Western Blot LINC00511 was upregulated in LUSC tissues in TCGA database compared to adjacent non-tumor counterparts, and its expression level was strongly associated with tumor stage. our study highlights that LINC00511 facilitates LUSC progression via sequestering miR-150-5p and targeting TADA1, suggesting a need for development of a strategy for therapeutic targeting of LINC00511 in LUSC. LINC00511 was upregulated in LUSC tissues in TCGA database compared to adjacent non-tumor counterparts, and its expression level was strongly associated with tumor stage. Yes LINC00511 deficiency significantly suppressed LUSC cell proliferation and migration. 32953492 LINC00504 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction(miR-876-3p-HMGB3 axis ) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay LINC00504 was upregulated in breast cancer tissues and cell lines. Regarding the underlying mechanism, LIN00504 could function as a competing endogenous RNA in breast cancer by sponging microRNA-876-3p (miR-876-3p), resulting in the upregulation of high mobility group box 3 (HMGB3). Yes Knocking down LINC00504 suppressed breast cancer cell proliferation, migration, and invasion and facilitated apoptosis in vitro. In addition, tumor growth in vivo was significantly inhibited by LINC00504 depletion. 33654429 LINC00504 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(miR-140-5p/VEGFA) In Vivo Experiment//Transwell Assay//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//IF//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//ChIP We found that LINC00504 is upregulated in breast cancer. In addition, we found that the transcription factor regulatory factor X5 (RFX5) can strongly bind to the LINC00504 promoter region and subsequently increase its transcriptional activity. We also found that the manipulation of RFX5 expression can significantly affect LINC00504 expression, which suggested that RFX5 can transcriptionally activate LINC00504 in breast cancer (BC). We further found that LINCOO504 inhibits miR-140-5p, which decreases the levels of VEGFA. The further results showed that miR-140-5p was one of the target gene of LINC00504. Yes Knockdown of LINC00504 inhibits cell proliferation, migration and invasion in vitro and in vivo. 34239305 LINC00504 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues,cell lines Interaction[c-Myc] qRT-PCR The lncRNA LINC00504 was markedly upregulated in colon cancer cell lines and specimens. Mechanistic study showed that LINC00504 could interact with c-Myc to promote chromatin recruitment of c-Myc and enhance its transactivation activity. Collectively, our results showed that LINC00504 serves as an important transcriptional regulator for c-Myc in colon cancer cells. LINC00504 can reprogram central metabolism in colon cancer cells implying that LINC00504 may serve as a potential target for therapeutic intervention. Yes LINC00504 increases viability and migration of colon cells in vitro. Furthermore, LINC00504 also enhances colon cancer xenograft tumors in vivo. 30998289 LINC00504 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines Interaction[ inhibition of miR-1244] qRT-PCR//MTT//Luciferase Report Assay//ELISA//Colony Formation Assay LINC00504 was upregulated in OC cell lines and specimens. Our study shows that LINC00504 promotes OC cell progression and stimulates aerobic glycolysis by interacting with miR-1244, which indicates that LINC00504 might act as a promising therapeutic target for OC treatment. Yes Knockdown of LINC00504 inhibited cell proliferation, enhanced apoptosis, decreased glycolysis-related gene (PKM2, HK2, and PDK1) expression, and altered aerobic glycolysis in OC cells and vice versa. 31691157 LINC00501 LncRNA Homo sapiens Lung Neoplasms regulation[miR-129-5p/HMGB1] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Transwell Assay LINC00501 was highly expressed in LC according to the database, and it was found that LINC00501 was upregulated in NSCLC specimens and cells, and the up-regulation indicated an unfavorable prognosis. In addition, LINC00501 can inhibit the invasion and migration of LC by mediating miR-129-5p/HMGB1. Yes Besides, knockdown of LINC00501 hindered the proliferation and invasion of NSCLC cells and intensified their apoptosis, and LINC00501 could be adopted as competitive endogenous RNA to regulate HMGB1 and tumorigenesis through miR-129-5p. 32801746 LINC00511 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction[miR-424] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//EdU Staining//Transwell Assay LINC00511 expression was significantly up-regulated in HCC tissues and cell lines, and its high expression was distinctly associated with nodal metastasis, vascular invasion, and clinical stage. LINC00511 plays an important role in the malignant progression of HCC via modulation of miR-424. LINC00511 expression was significantly up-regulated in HCC tissues and cell lines, and its high expression was distinctly associated with nodal metastasis, vascular invasion, and clinical stage. Furthermore, statistical assays revealed that HCC patients with higher LINC00511 expression levels had worse overall survival rates. Yes Functionally, the inhibition of LINC00511 significantly suppressed the capability of proliferation, migration, and invasion in HCC cell lines. 31081082 LINC00511 LncRNA Homo sapiens Colonic Neoplasms CC cells Interaction(miR-625-5p/WEE1) qRT-PCR//MTT//Colony Formation Assay//Transwell Assay CC tissues and cells highly expressed LINC00511 and WEE1 and lowly expressed miR-625-5p. LINC00511 was mainly localized in the cytoplasm. Deleted LINC00511 or restored miR-625-5p delayed cellular growth in CC. LINC00511 sponged miR-625-5p to target WEE1. Silenced miR-625-5p mitigated the role of depleted LINC00511, while inhibited WEE1 rescued the effect of silenced miR-625-5p on the biological functions of CC cells. Yes LINC00511 sponged miR-625-5p to target WEE1. Silenced miR-625-5p mitigated the role of depleted LINC00511, while inhibited WEE1 rescued the effect of silenced miR-625-5p on the biological functions of CC cells. 35477702 LINC00511 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-29c-3p/NFIA ) Transwell Assay//qRT-PCR//Colony Formation Assay//Western Blot Our results manifested that the expression level of LINC00511 was obviously upregulated in CRC tissues and cells and it accelerated CRC development through facilitating cell proliferation, metastasis and stemness.Molecular mechanism exploration uncovered that LINC00511 acted as a ceRNA competing with NFIA to bind with miR-29c-3p. Yes Our results manifested that the expression level of LINC00511 was obviously upregulated in CRC tissues and cells and it accelerated CRC development through facilitating cell proliferation, metastasis and stemness. 33536761 LINC00520 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cells regulation[ inhibiting miR-3175 expression] CCK8//qRT-PCR//RNA Pull-Down//Transwell Assay LINC00520 was highly expressed in lung cancer tissues and cells.LncRNA LINC00520 could predict poor prognosis and promote progression of lung cancer by inhibiting miR-3175 expression. Patients at III+IV stage were always with higher LINC00520 level than patients at I+II stage.Patients with high expression of lncRNA LINC00520 have short survival time (hazard ratio=1.7). Yes Knockdown of LINC00520 inhibited proliferation, invasion and migration of lung cancer cells. 32801856 LINC00520 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[LINC00520/miR-577/HSP27 axis ] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay In this study, high-LINC00520 expression was verified in CRC tissues and cell lines, and this high expression was associated with patients' unfavorable clinicopathological parameters and shorter overall survival and disease-free survival.LINC00520 functioned as an oncogenic lncRNA in CRC, and it facilitated CRC progression by regulating the miR-577/HSP27 axis, suggesting that the LINC00520/miR-577/HSP27 axis is an effective target in anticancer management. In this study, high-LINC00520 expression was verified in CRC tissues and cell lines, and this high expression was associated with patients' unfavorable clinicopathological parameters and shorter overall survival and disease-free survival. Yes Functionally, interference of LINC00520 resulted in a significant decrease of CRC cell proliferation, migration, colony forming ability, and invasion. 32146708 LINC00520 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines regulation[LINC00520/miR-577/Sphk2 axis ] qRT-PCR High LINC00520 expression was verified in PTC tissues and cell lines, and this high expression was associated with the unfavorable clinicopathological parameters and short overall survival of patients.LINC00520 functioned as an oncogenic lncRNA in PTC, and it facilitated PTC progression by regulating the miR-577/Sphk2 axis, suggesting that the LINC00520/miR-577/Sphk2 axis is an effective target in anticancer management. High LINC00520 expression was verified in PTC tissues and cell lines, and this high expression was associated with the unfavorable clinicopathological parameters and short overall survival of patients. Yes Functionally, LINC00520 interference resulted in a significant decrease in PTC cell proliferation, migration, and in vitro invasion and an increase in cell apoptosis. Further, its downregulation impaired tumor growth in vivo. 32075502 LINC00520 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-4516/SOX5 axis) Other The present study identified that LINC00520 was upregulated in HCC tissues and indicated poor patient survival. Furthermore, LINC00520 acted as a sponge of miR-4516 to regulate SRY-related high mobility group box 5 (SOX5). In addition, the inhibition of miR-4516 partly reversed the inhibitory effect of LINC00520 silencing on HCC cell proliferation, migration and invasion. The present study identified that LINC00520 was upregulated in HCC tissues and indicated poor patient survival. Yes Overexpression of LINC00520 promoted HCC cell proliferation, migration and invasion, while LINC00520 downregulation led to the opposite effects. Besides, LINC00520 knockdown was found to inhibit tumor growth in vivo. 35089659 LINC00520 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC cells and tissues regulation[LINC00520/miR-195/HOXA10] qRT-PCR//RNA Pull-Down//RIP LINC00520 was upregulated while miR-195 was downregulated in HNSCC cells and tissues.LINC00520/miR-195/HOXA10 is involved in the radiosensitivity mediation, providing potential therapeutic target for HNSCC treatment. Yes Silencing LINC00520 or overexpressing miR-195 promoted radiosensitivity and inhibited cell proliferation, invasion, migration, and apoptosis in HNSCC. 32462956 LINC00520 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Regulation[miR-26b-3p/USP39 axis] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//IHC Results indicated that LINC00520 was significantly increasing in NPC tissues and cells in comparison to their corresponding controls.Taken together, our study discovered the oncogenic role of LINC00520 in clinical specimens and cellular experiments, showing the potential LINC00520/miR-26b-3p/USP39 pathway. This results and findings provide a novel insight for NPC tumorigenesis. Yes Silence of LINC00520 was able to repress NPC cell growth in vitro while overexpression of LINC00520 inversed this process. 30898716 LINC00520 LncRNA Homo sapiens Adenocarcinoma of Lung lung ADC tissues and cell lines Interaction(miR-1252-5p/FOXR2 pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay We found that LINC00520 level was elevated in lung ADC tissues and cell lines. Besides, the LINC00520 expression had a negative connection with miR-1252-5p level in lung ADC tissues. Additionally, our results demonstrated the reciprocal repression influence between LINC00520 and miR-1252-5p. Additionally, the findings also demonstrated that FOXR2 was a target of miR-1252-5p; thus, LINC00520 could regulate FOXR2 level. Yes Furthermore, knockdown of LINC00520 inhibited lung ADC cells proliferation, migration and invasion, while co-transfection with a miR-1252-5p inhibitor inverted these influences. 33464477 LINC00520 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD specimens and adjacent non-tumor tissues Expression(highly expressed) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//ChIP We found that LINC00520 was upregulated in LUAD. Additionally, LINC00520 upregulation is associated with the poor prognosis for patients with LUAD. Furthermore, LINC00520 downregulation suppressed LUAD cell proliferation and migration and induced cell apoptosis. Forkhead box P3 (FOXP3) is identified as the transcription factor to transcriptionally activate LINC00520. Moreover, LINC00520 positively upregulated FOXP3 expression via sponging miR-3611 in LUAD cells. Subsequently, rescue experiments delineated that miR-3611 downregulation or FOXP3 overexpression reversed the effects of silenced LINC00520 on proliferative and migratory capabilities in LUAD cells. Additionally, LINC00520 upregulation is associated with the poor prognosis for patients with LUAD. Yes function of LINC00520 in LUAD was verified by in vitro loss-of-function experiments. 34496829 LINC00519 LncRNA Homo sapiens lung squamous cell carcinoma LUSC tissues and cell lines regulation[miR-450b-5p/miR-515-5p/YAP1 axis] RNA Pull-Down//qRT-PCR//RIP//FISH//Luciferase Report Assay Elevated level of LINC00519 was identified in LUSC tissues and cell lines. H3K27ac-activated LINC00519 acts as a competing endogenous RNA (ceRNA) to promote LUSC progression by targeting miR-450b-5p/miR-515-5p/YAP1 axis. High LINC00519 level predicted unsatisfactory prognosis. Yes Then, loss-of-function assays suggested the inhibitive role of silenced LINC00519 in cell proliferation, migration, invasion and tumour growth and promoting effect on cell apoptosis in LUSC. 32297697 LINC00518 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Regulation[JAK/STAT3 signaling] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay We found that LINC00518 was upregulated in CC tissues and associated with International Federation of Gynaecology and Obstetrics (FIGO) stage, lymph node metastasis, depth of cervical invasion and poor survival of CC patients. The present work first suggests that LINC00518 acts as an oncogene in CC via regulation of the JAK/STAT3 signaling pathway. We found that LINC00518 was upregulated in CC tissues and associated with International Federation of Gynaecology and Obstetrics (FIGO) stage, lymph node metastasis, depth of cervical invasion and poor survival of CC patients. Yes Furthermore, knocking down LINC00518 expression significantly suppressed CC cell proliferation, migration and invasion, and induced apoptosis in vitro. 30720156 LINC00518 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD specimens and cell lines Interaction(miR-185-3p/MECP2) In Vivo Experiment//IHC//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining We found that LINC00518 was highly expressed in LUAD specimens and the high-expression was negatively correlated with the overall survival rates. This finding was also proved in the LUAD cell lines. Through a series of in vitro and in vivo experiments, we proved that LICN00518 promoted the cell growth of LUAD by regulating the cell cycle. Moreover, LICN00518 upregulated the expression of MECP2 by mutagenesis of miR-185-3p. We found that LINC00518 was highly expressed in LUAD specimens and the high-expression was negatively correlated with the overall survival rates. Yes Through a series of in vitro and in vivo experiments, we proved that LICN00518 promoted the cell growth of LUAD by regulating the cell cycle. 33937054 LINC00518 LncRNA Homo sapiens Melanoma melanoma tissues and cells Interaction(EIF4A3/MITF axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay In our study, LINC00518 was revealed to be upregulated in melanoma tissues and cells, and melanoma patients in high LINC00518 expression group had poorer prognosis as depicted in GEPIA database. Additionally, results of mechanism assays uncovered EIF4A3 could bind with LINC00518 and MITF, and LINC00518 recruited EIF4A3 to stabilize MITF mRNA. Finally, it was demonstrated that upregulation of MITF could partially abrogate the inhibitory impact of LINC00518 knockdown on melanoma cell malignant behaviors. In our study, LINC00518 was revealed to be upregulated in melanoma tissues and cells, and melanoma patients in high LINC00518 expression group had poorer prognosis as depicted in GEPIA database. Yes Functional assays revealed that LINC00518 depletion inhibited cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT). 35813236 LINC00518 LncRNA Homo sapiens Melanoma CMM tissues and cells Interaction(miR-526b-3p/EIF5A2 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay LINC00518 and EIF5A2 were up-regulated and miR-526b-3p was down-regulated in CMM tissues and cells. LINC00518 bound to miR-526b-3p and miR-526b-3p targeted EIF5A2. LINC00518 negatively regulated miR-526b-3p expression but positively regulated EIF5A2. Furthermore, EIF5A2 expression was negatively associated with miR-526b-3p expression. CMM patients with highly expressed LINC00518 showed decreased survival time than those with lowly expressed LINC00518. Yes Transfection of si-LINC00518, miR-526b-5p mimic or si-EIF5A2 weakened the proliferative, migratory, and invasive abilities of melanoma cells, while transfection of miR-526b-5p inhibitor or pcDNA-LINC00518 enhanced the progression of melanoma cells. Moreover, the proliferative, migratory, and invasive potentials of melanoma cells were decreased after co-transfection of si-EIF5A2 and pcDNA-LINC00518 compared with cells transfected with pcDNA-LINC00518 alone. 35189053 LINC00511 LncRNA Homo sapiens Stomach Neoplasms GC cells regulation[miR-124-3p/PDK4 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay The expression of LINC00511 was remarkably upregulated in GC cells compared to that in corresponding normal cell lines. These data demonstrate that LINC00511 promotes gastric cancer cell growth by acting as a ceRNA to regulate the miR-124-3p/PDK4 axis, which may be a promising therapeutic target for GC. Yes Compared to the controls, cell proliferation was inhibited, and cell apoptosis was increased upon LINC00511 knockdown, demonstrating that LINC00511 influenced GC cell growth. 32368318 LINC00511 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-625-5p/STAT3 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay We reported that LINC00511 and STAT3 expressions in GC tissues and cell lines were observably up-regulated, while miR-625-5p expression was inhibited. Yes High expression of LINC00511 could facilitate the proliferation and promote the migration of GC cells. Additionally, knockdown of LINC00511 suppressed the growth and lung metastases of CRC cells in nude mice. 34224294 LINC00511 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues regulation[LINC00511/miR-150/MMP13 axis] qRT-PCR//Luciferase Report Assay In this study, LINC00511 was significantly up-regulated in breast cancer, and its expression level was correlated to poor prognosis of patients with breast cancer.In conclusion, our data show that LINC00511 is a breast cancer promoter, and the LINC00511/miR-150/MMP13 axis may be a new therapeutic strategy for breast cancer patients. In this study, LINC00511 was significantly up-regulated in breast cancer, and its expression level was correlated to poor prognosis of patients with breast cancer. Yes Cells transfected with siRNA-2 proliferated, and its metastasis was suppressed. 33031905 LINC00511 LncRNA Homo sapiens Breast Neoplasms breast cancer samples Expression(highly expressed) Bioinformatics Analysis It was found that the role of LINC00511 was overexpressed in breast cancer samples, and this overexpression was ascribed to a poor prognosis. Yes It was found that the role of LINC00511 was overexpressed in breast cancer samples, and this overexpression was ascribed to a poor prognosis. 35790898 LINC00511 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissues Interaction(miR-625-5p/GSPT1) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay LINC00511 expression was clearly higher in the tumor tissues of the NSCLC patients than in normal tissues (P<0.001). LINC00511 promoted GSPT1 expression via suppressing miR-625-5p. High LINC00511 expression was related to larger tumor size, positive lymph node metastasis, advanced TNM stage, and a lower 5-year survival rate. Yes Compared with those of the shNC group, the NSCLC cells of the shLINC00511 group had a prominently lower optical density (OD) 450 value at 72 h, a lower percentage of cells in S phase, a higher relative wound width, and a lower invasive cell number (P<0.01 or P<0.001). Compared with those of the shNC group, the nude mice of the shLINC00511 group had a much lower subcutaneous tumor volume and weight (P<0.05 or P<0.001). 35116366 LINC00511 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue samples and cell lines regulation[HIF-1α/LINC00511/miR-153-5p] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//ChIP Here, present research found that LINC00511 was significantly up-regulated in the CRC tissue samples and cell lines.In conclusion, this study identifies the roles of LINC00511 in CRC progression and uncovers the positive feedback loop of HIF-1α/LINC00511/miR-153-5p in CRC, providing a potential therapeutic target. Consistently, LINC00011 overexpression was correlated with larger tumor size and advanced tumor stage. Yes Functionally, LINC00511 promoted the proliferation and reduced the apoptosis of CRC cells in vitro, and LINC00511 knockdown repressed tumor growth in vivo. 32092829 LINC00494 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer cells and tissues regulation[NFκB1 and FBXO32] RNA Pull-Down//ChIP//RIP//Luciferase Report Assay//Transwell Assay LINC00494 and NFκB1 were highly expressed whereas FBXO32 had low expression in ovarian cancer cells and tissues. Our work demonstrated that LINC00494 promoted ovarian cancer progression by modulating FBXO32 via binding with the transcription factor NFκB1. Yes Overexpression of LINC00494 elevated NFκB1 expression and enhanced cell migration, invasion and tumorigenesis, but additional overexpression of FBXO32 interfered with the tumorgenicity of ovarian cancer cells in vitro and in vivo. 33585183 LINC00491 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Expression [highly expressed] Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//RNA-seq//Invasion Assay The reverse transcription‑quantitative PCR results suggested that LINC00491 was upregulated in ESCC tissues and cells. Yes The results showed that lower expression of LINC00491 resulted in decreased cell proliferation and migration and increased the apoptosis rate. 33537830 LINC00491 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(LINC00491/MTSS1/Wnt/β-catenin-signaling pathway ) In Vivo Experiment//Western Blot//Wound Healing Assay//FISH//Colony Formation Assay Our results showed that LINC0491 was significantly upregulated in LUAD and positively correlated with poor survival. Using pull-down assay and mass spectrometry, MTSS1 was found binding to LINC00491, and the conducted experiments verified the direct interaction between LINC00491 and MTSS1. Meanwhile, LINC00491 was found to regulate MTSS1 degradation by promoting the MTSS1 ubiquitination level and then activating the Wnt/β-catenin-signaling pathway. LINC00491/MTSS1/β-catenin may act as a complex to facilitate tumor progression. Our results showed that LINC00491 was significantly upregulated in LUAD and positively correlated with poor survival. Yes High LINC00491 expression promoted proliferation, migration and invasion, and resulted in a high metastatic burden in LUAD. 36496997 LINC00472 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck several squamous cell carcinoma cancer tissues and OSCC cell lines Interaction(miR-4311/GNG7 axis) qRT-PCR//MTT//Western Blot This study found that LncRNA LINC00472 was significantly down-regulated in several squamous cell carcinoma cancer tissues and OSCC cell lines. Additionally, we confirmed that LINC00472 functioned as an hsa-miR-4311 sponge and regulated the expression of GNG7 (guanine nucleotide-binding protein, gamma 7). Yes Over-expression of LINC00472 in OSCC cells inhibited OSCC progression and alleviated OSCC immune responses.Also, we found that LINC00472 over-expression could suppress xenograft tumor growth in vivo. 35240924 LINC00472 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines interaction[miR-300 and FOXO1] qRT-PCR The expressions of LINC00472 were inhibited in OS tissues and cells, and were negatively related to the expressions of miR-300. From all the experiments and observations, we demonstrated that LINC00472 could be a potential tumor suppressor in OS through interacting with miR-300 and FOXO1. Yes LINC00472 over-expressions decreased cell proliferation abilities and colony formation abilities. 32256209 LINC00472 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Expression [lower expressed] In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//qRT-PCR//RIP//H&E Staining//EdU Staining//Transwell Assay  In this study, we found the lncRNA LINC00472 was poorly expressed in TNBC tissues and cells. LINC00472 induced site-specific DNA methylation and reduced the MCM6 expression by recruiting DNA methyltransferases into the MCM6 promoter. Yes Overexpression of LINC00472 could inhibit the proliferation, invasion and migration of MDA-MB-231 cells. On the contrary, minichromosome maintenance complex component 6 (MCM6) was highly expressed in TNBC tissues and MDA-MB-231 cells due to suppressed methylation. 33668040 LINC00472 LncRNA Mus musculus Acute Hepatic Injury liver tissues regulation[miR-373-3p/TRIM8 axis] CCK8//qRT-PCR//RIP//Luciferase Report Assay//ELISA LINC00472 and TRIM8 were significantly upregulated in liver tissues and THLE-3 cells in sepsis-induced AHI models, while miR-373-3p was downregulated.Downregulation of LINC00472 ameliorates sepsis-induced AHI by regulating the miR-373-3p/TRIM8 axis. Yes Silencing of LINC00472 promoted cell viability and suppressed cell apoptosis in LPS-treated THLE-3 cells, whereas upregulation of LINC00472 had the opposite effect. 33129786 LINC00470 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[PTEN ] RNA Pull-Down//MeRIP//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay In this study, our findings showed that LINC00470 was significantly upregulated in GC tissues and cell lines.Overexpression and knockdown experiments revealed its oncogenic functions on GC cell proliferation, migration and invasion. In this study, our findings showed that LINC00470 was significantly upregulated in GC tissues and cell lines, and correlated with distant metastasis, TNM stage and poor prognosis. Yes Overexpression and knockdown experiments revealed its oncogenic functions on GC cell proliferation, migration and invasion. 31711642 LINC00470 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction[association with NF45/NF90 complex] qRT-PCR Here, we found that LINC00470 was upregulated in HCC cells and tissues. Further investigation suggested that LINC00470 was associated with NF45/NF90 complex and increased its interaction with cyclin E1 mRNA, thus inhibiting the degradation of cyclin E1 mRNA. High-level LINC00470 was significantly correlated with bigger tumor size, advanced TNM stage and poor prognosis in patients with HCC. Yes Functional studies showed that knockdown of LINC00470 expression inhibited HCC cell proliferation and cell cycle progression, while overexpression of LINC00470 showed the opposite effects. 31612313 LINC00470 LncRNA Homo sapiens Glioma serum derived exosome Interaction(miR-580-3p/WEE1/PI3K/AKT/mTOR pathway) Western Blot//Transfection//Colony Formation Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC LINC00470 overexpressed in GBM-exo and associated with disease severity and postoperative survival time of glioma patients. The PI3K/AKT/mTOR pathway was activated. LINC00470 competitively bound to miR-580-3p with WEE1. LINC00470 overexpressed in GBM-exo and associated with disease severity and postoperative survival time of glioma patients. GBM-exo deteriorated tumor progression in nude mice. Yes Cells incubated with GBM-exo or transfected with pcDNA3.1-LINC00470/miR-580-3p inhibitor/pcDNA3.1-WEE1 had less autophagosome, downregulated LC3-II/LC3-I and Beclin1 expression levels and increased expression of p62 as well as strengthened proliferation ability 33663509 LINC00467 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression [highly expressed] Western Blot//Flow Cytometry//FISH//qRT-PCR//MTT//Colony Formation Assay//Bioinformatics Analysis Levels of LINC00467 and ITGB3 were up-regulated in GC, and highly expressed LINC00467 was positively associated with tumor size, differentiation, N stage, and T stage in GC patients. Levels of LINC00467 and ITGB3 were up-regulated in GC, and highly expressed LINC00467 was positively associated with tumor size, differentiation, N stage, and T stage in GC patients. Yes . LINC00467 was enriched in cytoplasm of GC cells, and overexpressed LINC00467 promoted the viability and proliferation as well as levels of ITGB3 and PCNA, while suppressing the apoptosis and levels of cleaved caspase-3 and cleaved PARP1 in GC cells. 34555778 LINC00467 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(miR-138-5p and LIN28B) qRT-PCR//Luciferase Report Assay//RIP//Western Blot "A higher expression level of LINC00467 was observed in breast cancer tissues as compared to the adjacent normal counterparts and elevated LINC00467 predicted poor overall survival . LINC00467 down-regulated miR-138-5p by acting as a miRNA ""sponge"". Besides, LINC00467 also up-regulated the protein level of lin-28 homolog B (LIN28B) via a direct interaction. " Yes Silence of LINC00467 suppressed proliferation, migration, invasion and epithelial-to-mesenchymal transition (EMT) of breast cancer cells in vitro, whereas forced expression of LINC00467 exhibited the opposite effects. Furthermore, we demonstrated overexpression of LINC00467 promoted tumor growth, while knockdown of LINC00467 inhibited pulmonary metastasis in vivo. 33996559 LINC00467 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[ Akt signal pathway] qRT-PCR LINC00467 highly expressed in NSCLC tissues and associated with advanced clinical stages and poor outcome. In conclusion, LINC00467 promotes NSCLC progression via Akt signal pathway. LINC00467 highly expressed in NSCLC tissues and associated with advanced clinical stages and poor outcome. Yes Knockdown of LINC00467 inhibited cell growth and metastasis via regulating the Akt signaling pathway. 32796958 LINC00467 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma regulation[miR-485-5p/DPAGT1 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay According to experimental results, we found out upregulated LINC00467 improved cell proliferation, but hindered cell apoptosis. We proved that LINC00467 acted as an oncogene in ESCC by accelerating cell proliferation and preventing cell apoptosis via miR-485-5p/DPAGT1 axis. Yes Rescue assays suggested that DPAGT1 amplification was able to recover the influence of LINC00467 deficiency on cell proliferation and apoptosis. Furthermore, knockdown of LINC00467 suppressed tumor growth in vivo. 32720371 LINC00467 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR In this study, we report a novel lncRNA, LINC00467, which was significantly up-regulated in CRC; we investigated its function and mechanism in CRC. We used the Gene Expression Omnibus (GEO) and Gene Expression Profiling Interactive Analysis (GEPIA) databases for the analysis and measurement of clinical samples, and observed that the CRC patients with high LINC00467 expression levels showed poor overall survival (OS) and recurrent-free survival (RFS) rates. Yes Furthermore, following the short interfering RNA (siRNA) knockdown of LINC00467 in the CRC cell line, the results demonstrated that LINC00467 suppresses the proliferation, invasion and metastasis of CRC cells in vitro. 31772673 LINC00467 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues interaction[microRNA-451a] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay Consequently, linc00467 was revealed to be overexpressed in human CRC tissues, and its expression was significantly associated with metastasis and Tumor-Node-Metastasis stage. In conclusion, the results of the present study indicate that increased linc00467 expression promotes metastasis by targeting miR-451a, which ultimately increases cellular proliferation and inhibits apoptosis in human CRC cells. Consequently, linc00467 was revealed to be overexpressed in human CRC tissues, and its expression was significantly associated with metastasis and Tumor-Node-Metastasis stage. Yes In HT29 and HCT116 cells, linc00467-knockout was revealed to decrease cellular proliferation and increase apoptosis (P<0.05). 32934693 LINC00467 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[LINC00467/miR-9-5p/PPARA signalling] qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay It was found that LINC00467 was aberrantly decreased in HCC.Our data indicate the critical involvement of LINC00467/miR-9-5p/PPARA signalling in the incidence and progression of HCC. Yes The ectopic expression of LINC00467 significantly suppressed cell viability, proliferation, migration and invasion. 31480990 LINC00467 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and HCC cell lines regulation[inhibiting NR4A3] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Cell Apoptosis Assay//Cell Cycle Assay//Transwell Assay Our findings revealed that LINC00467 was up-regulated in HCC tissues and HCC cell lines.Targeting LINC00467 or enhancing NR4A3 may be potential therapeutic strategies against HCC. Yes In vitro functional experiments revealed that LINC00467 accelerated HCC cell proliferation, cell cycle progression and migration and reduced HCC cell apoptosis. In vivo functional assays revealed that LINC00467 drove HCC xenograft growth and HCC cell proliferation and repressed HCC cell apoptosis in vivo. 32125766 LINC00467 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-18a-5p/NEDD9 axis] qRT-PCR We observed that linc00467 was upregulated in HCC tissues and cells. In conclusion, our data highlighted the oncogenic role of linc00467 in HCC progression by regulating the miR-18a-5p/NEDD9 axis. Yes Silencing of linc00467 using small interfering RNA interference significantly inhibited the growth and motility of HCC cells, and increased cell apoptosis through regulating the Bcl-2/Bax axis and the caspase cascade, suggesting that linc00467 exerted oncogenic functions in the progression of HCC. 31916278 LINC00467 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells interaction[IGF2BP3,TRAF5 ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay LINC00467 upregulation in HCC tissues and cells was observed.LINC00467 promotes cell proliferation and metastasis by binding with IGF2BP3 to enhance the mRNA stability of TRAF5 in HCC. Yes LINC00467 silencing suppressed cell proliferation and metastasis, whereas it facilitated cell apoptosis in HCC. 31656043 LINC00467 LncRNA Homo sapiens Osteosarcoma OS tissues and cells regulation[HMGA1 ,miR-217] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Transwell Assay The expression of LINC00467 and HMGA1 was increased in OS tissues and cells, while miR-217 expression was reduced. High expression of HMGA1 led to the poor overall survival. Yes Down-regulation of LINC00467 or up-regulation of miR-217 could accelerate cell apoptosis, and slump cell proliferation, migration, invasion and EMT. 32572906 LINC00472 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Mutation[miR-93-5p/PDCD4 pathway] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay In the present study, we have demonstrated that long non-coding RNA (lncRNA) LINC00472 was low expressed in human HCC tissues and cell lines compared with adjacent non-tumor liver tissues and normal liver cell lines respectively.MiR-93-5p was a direct target of LINC00472, and miR-93-5p directly targeted PDCD4. The miR-93-5p/PDCD4 pathway mediated the suppressing role of LINC00472 in HCC cells. Expression level of LINC00472 was positively correlated with patient overall survival (OS) rate. Yes Forced expression of LINC00472 suppressed cell proliferation, migration, invasion and promoted cell apoptosis in HCC cells Huh-7 and SMMC-7721. 30522853 LINC00472 LncRNA Homo sapiens Breast Neoplasms cell lines Interaction[NF-κB] Western Blot//Migration Assay//CCK8//RIP//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay Analysis of LINC00472 transcriptome revealed ERα upregulation of LINC00472 expression, and an ERα-binding site in the LINC00472 promoter was identified.Evaluation of LINC00472 overexpression also indicated a possible link between LINC00472 and NF-κB. Cell experiments confirmed that LINC00472 suppressed the phosphorylation of p65 and IκBα through binding to IKKβ, inhibiting its phosphorylation.Tamoxifen treatment of ER-positive cells inhibited ERα and LINC00472 expression and increased p65 and IκBα phosphorylation. Meta-analysis showed that LINC00472 expression were higher in ER-positive than ER-negative tumors and that high expression was associated with better disease outcomes in ER-positive patients. Yes High LINC00472 expression inhibited tumor growth both in vitro and in vivo and suppressed aggressive tumor cell behaviors in vitro. Suppressing LINC00472 expression in ER-positive tumor cells increased cell aggressive behaviors. 30830488 LINC00472 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR Among them, the expression level of Linc00472 significantly decreased in gastric cancer tissues compared to adjacent normal tissues. Yes Ectopic Linc00472 expression could significantly inhibit gastric cancer cell growth and migration. 31570433 LINC00473 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction(miR-424-5p/CCNE1 Pathway) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay LINC00473 expression was elevated in BC tissues and cell lines, which was associated with lymph node metastasis and higher clinical stage of the patients with BC. LINC00473 proved to be a molecular sponge for miR-424-5p; LINC00473 knockdown impeded the growth, migration, invasion, and epithelial-mesenchymal transition of BC cells, while these effects were abolished by miR-424-5p inhibitors; miR-424-5p targeted CCNE1 to restrain its expression. LINC00473 positively regulated CCNE1 expression, and CCNE1 restoration counteracted the effects induced by LINC00473 knockdown in BC cells. LINC00473 expression was elevated in BC tissues and cell lines, which was associated with lymph node metastasis and higher clinical stage of the patients with BC. Yes LINC00473 proved to be a molecular sponge for miR-424-5p; LINC00473 knockdown impeded the growth, migration, invasion, and epithelial-mesenchymal transition of BC cells, while these effects were abolished by miR-424-5p inhibitors; miR-424-5p targeted CCNE1 to restrain its expression. 36305147 LINC00491 LncRNA Homo sapiens Liver Neoplasms liver cancer patients and cells&Xenograft tumor and lung tissues of mice Interaction(miR-324-5p/ROCK1) In Vivo Experiment//cell invasion assay//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay LINC00491 was highly expressed in liver cancer cases, associating with poor prognosis. LINC00491 promoted ROCK1 expression by reducing miR-324-5p. miR-324-5p up-regulation or ROCK1 knockdown reversed LINC00491 promotion on liver SK-Hep-1 cells malignant phenotype. LINC00491 was highly expressed in liver cancer patients, associating with poor prognosis. Yes si-LINC00491 inhibited proliferation, colony formation, invasion, migration, and induced cell cycle G1 arrest and apoptosis in HUH-7 and SK-Hep-1 cells. LINC00491 overexpression showed opposite effects.LINC00491 facilitated xenograft tumor growth and lung metastasis in mice. 34876144 LINC00485 LncRNA Homo sapiens Lung Neoplasms lung cancer tissue regulation[miR-298/c-Myc axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this study, we found that the expression of Linc00485 was significantly increased in human lung cancer tissue and associated with malignant phenotypes, including tumour-node-metastasis (TNM) stage, metastasis and relapse. Overall, these findings indicate that Linc00485 overexpression down-regulates miR-298, resulting in the up-regulation of c-Myc and thereby promoting the development of lung cancer. In this study, we found that the expression of Linc00485 was significantly increased in human lung cancer tissue and associated with malignant phenotypes, including tumour-node-metastasis (TNM) stage, metastasis and relapse. Yes Furthermore, the proliferative, migratory and invasive abilities of lung cancer cells in vitro were significantly enhanced by overexpression of Linc00485 but inhibited by its silencing. 33237626 LINC00485 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cancer cells Interaction( miR-581/EDEM1 axis) qRT-PCR//Colony Formation Assay//Western Blot We found that LINC00485 expression was significantly lower in CRC tissues and cancer cells than in paired normal samples and human normal colonic epithelial cells.MicroRNA miR-581 was the downstream target of LINC00485, which was downregulated in CRC samples and cancer cells compared to normal tissues and normal colonic epithelial cells. MiR-581 overexpression induced proliferation, migration, and invasion of FHC cells, while miR-581 antagomir treatment produced opposite results. MiR-581 directly targeted the 3'UTR of EDEM1 and inhibited its expression and induction of epithelial-mesenchymal transition of CRC. Lower expression of LINC00485 predicted poor prognosis in CRC patients. Yes In mouse models, LINC00485 knockdown or down-regulation of miR-581 significantly repressed CRC cell growth and prevented CRC liver metastasis. LINC00485 knockdown promoted the proliferation, migration, and invasion of FHC cells, while LINC00485 overexpression weakened these abilities of LoVo cells. 33461166 LINC00477 LncRNA Homo sapiens Polycystic Ovary Syndrome serum of PCOS patients Interaction(miR-128 axis) ISH//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay LINC00477 was significantly upregulated in the serum of PCOS patients as well as PCOS mouse models. Moreover, miR-128 mimics partially abrogated the effect of LINC00477 on granulosa cells. Yes LINC00477 overexpression inhibited the proliferation and promoted the apoptosis of granulosa cells, whereas knockdown of LINC00477 yielded the opposite effects. 33622342 LINC00473 LncRNA Homo sapiens Stomach Neoplasms GC tissue samples and GC cell lines Expression[highly expressed] qRT-PCR In our results, LINC00473 expression was increased in GC tissue samples and GC cell lines compared with paired adjacent normal stomach tissue samples and normal gastric epithelial cell line, respectively. High-expression of LINC00473 was correlated with poor histological type, advanced clinical stage, more lymph node metastasis and present distant metastasis. Yes The study in vitro indicated that silencing of LINC00473 had no effect on GC cell viability, but inhibited GC cell migration and invasion through modulating MMP2 and MMP9 expression. 30071345 LINC00473 LncRNA Homo sapiens Breast Neoplasms cell lines Interaction[CCND1 ] qRT-PCR Here, we found that lncRNA LINC00473 is significantly upregulated in breast cancer cells.Altogether, the activation effect of LINC00473 on CCND1 is a net effect of two antagonistic regulatory pathways. Our finding provides a novel lncRNA-mediated precise transcriptional control of CCND1. Yes Loss- or gain-of-function experiments show that LINC00473 promotes cell proliferation. 30848493 LINC00473 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Interaction(miR-497-5p) Western Blot//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay LINC00473 expression was upregulated in lung cancer tissues and NSCLC cells (A549 and H1299) when compared with adjacent tissues or human bronchial epithelial cell lines and the 5-year survival rate was lower in patients with high LINC00473 expression compared with in patients with low LINC00473 expression.A negative correlation between LINC00473 and miR-497-5p was observed in lung cancer tissues. Notably, it was demonstrated that LINC00473 could bind directly with miR-497-5p and inhibit its expression. miR-497-5p inhibitors reversed the effect of si-LINC00473. LINC00473 expression was upregulated in lung cancer tissues and NSCLC cells (A549 and H1299) when compared with adjacent tissues or human bronchial epithelial cell lines and the 5-year survival rate was lower in patients with high LINC00473 expression compared with in patients with low LINC00473 expression. Yes Proliferation, migration and invasion as well as the related protein levels were increased in A549 and H1299 transfected with pcDNA3.1-LINC00473, while the opposite results were obtained in A549 and H1299 transfected with small interfering (si)-LINC00473. 33868467 LINC00473 LncRNA Rattus norvegicus Osteoarthritis C28/I2 cells Interaction(miR-424-5p/LY6E axis) Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay//ELISA//Bioinformatics Analysis The results indicated that, compared with the OA + adeno-associated virus si-NC group, LINC00473 knockdown significantly suppressed the degradation of chondrocyte extracellular matrix and the production of proinflammatory cytokines in OA model rats. Furthermore, bioinformatics analysis, luciferase reporter and RNA immunoprecipitation assays indicated that LINC00473 served as a microRNA (miR)-424-5p sponge in C28/I2 cells, and that lymphocyte antigen 6 locus E (LY6E) was the downstream target. In addition, the inhibitory effects of LINC00473 knockdown on chondrocyte apoptosis and the inflammatory response could be reversed by LY6E overexpression in IL-1β-stimulated C28/I2 cells. In summary, the findings indicated that LINC00473 contributed to OA progression by modulating the miR-424-5p/LY6E axis, which may serve as a potential therapeutic strategy for patients with OA. Yes LINC00473 knockdown significantly suppressed the degradation of chondrocyte extracellular matrix and the production of proinflammatory cytokines in OA model rats. Furthermore, bioinformatics analysis, luciferase reporter and RNA immunoprecipitation assays indicated that LINC00473 served as a microRNA (miR)-424-5p sponge in C28/I2 cells, and that lymphocyte antigen 6 locus E (LY6E) was the downstream target. In addition, the inhibitory effects of LINC00473 knockdown on chondrocyte apoptosis and the inflammatory response could be reversed by LY6E overexpression in IL-1β-stimulated C28/I2 cells. 34539843 LINC00473 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cell lines Regulation[miR-497-5p/PRKAA1 axis] Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay LINC00473 presented much higher expression and LINC00473 suppression restrained the proliferation, migration, and epithelial-mesenchymal transition (EMT) process in ESCC cells.LINC00473 regulates ESCC progression through miR-497-5p/PRKAA1 axis, which provides a new therapeutic strategy for ESCC patients. Yes LINC00473 presented much higher expression and LINC00473 suppression restrained the proliferation, migration, and epithelial-mesenchymal transition (EMT) process in ESCC cells. 31584290 LINC00473 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues from patients with distant metastasis Interaction(miR-195) qRT-PCR//Luciferase Report Assay The expression of LINC00473 in colorectal cancer tissues from patients with distant metastasis was higher than that from cases without distant metastasis.These data suggested that LINC00473 induced cell proliferation, cell cycle progression and EMT progression by acting as a ceRNA for miR-195 in colorectal cancer. The higher expression level of LINC00473 was positively correlated with advanced clinical stage. Yes The elevated expression of LINC00473 accelerated colorectal cancer cell proliferation, cell cycle progression and invasion. Moreover, overexpression of LINC00473 induced epithelial to mesenchymal (EMT) progression in HT29 and SW480 cells. 34306345 LINC00473 LncRNA Homo sapiens Glioma glioma tissues,cell lines Regulation[YAP1‑TEAD1‑Hippo signaling] Western Blot//Wound Healing Assay//CCK8//Flow Cytometry//RIP//qRT-PCR//Luciferase Report Assay//Transwell Assay In the present study, LINC00473 was significantly increased in glioma tissues and in cell models, and predicted a poor prognosis in patients with glioma. Mechanistically, LINC00473 functioned as a competing endogenous (ce)RNA to decrease microRNA (miR)‑195‑5p expression. Moreover, Yes‑associated protein 1 (YAP1) and TEA domain family member 1 (TEAD1) were identified as downstream targets of miR‑195‑5p, whose expression levels were inhibited by miR‑195‑5p. LINC00473 knockdown suppressed glioma progression through the decrease of miR‑195‑5p and subsequent increase of YAP1 and TEAD1 expression levels. Yes Notably, LINC00473 knockdown not only suppressed cell proliferation, invasion and migration of glioma cells, but also blocked cell cycle progression and induced apoptosis. Subcutaneous xenotransplanted tumor model experiments revealed that reduced LINC00473 expression was able to suppress in vivo glioma growth. 31894297 LINC00473 LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[miR-637/CDK6 axis] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, LINC00473 was notably elevated in glioma tissues and cell lines. Thus, we demonstrated that LINC00473 could act as a ceRNA of miR-637 to promote glioma progression through regulating CDK6 expression, which provided a potential therapeutic target for treatment of glioma patients. High LINC00473 expression was associated with advanced WHO grade (III-IV), low Karnofsky performance score (KPS), and poor prognosis. Yes Loss function assays showed that LINC00473 knockdown decreased glioma cell proliferation, invasion and epithelial-mesenchymal transition (EMT) processes in vitro, and reduced tumor growth in vivo. 31561732 LINC00473 LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues and cells regulation[miR-1294/ROBO1 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results showed that LINC00473 was up-regulated and miR-1294 was down-regulated in lung adenocarcinoma tissues and cells.In conclusion, LINC00473 acts as a tumor promoter in lung adenocarcinoma by regulating the miR-1294/ROBO1 axis. Yes Functionally, LINC00473 promoted cell proliferation and motility in lung adenocarcinoma by downregulating miR-1294. 32351100 Linc00473 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cell lines regulation[DDX5,miR-506] qRT-PCR//Luciferase Report Assay//RIP Linc00473 was highly expressed in CCA tissues and cell lines. Furthermore, linc00473 acted as miR-506 sponge and regulated its target gene DDX5 expression. Rescue assays verified that linc00473 modulated the tumorigenesis of CCA by regulating miR-506. Yes Linc00473 knockdown inhibited CCA growth and metastasis. 32694946 LINC00473 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer cells regulation[miR-195-5p/SEPT2 axis ] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay In the present study, we discovered that prostate cancer cells presented high expression of LINC00473, and LINC00473 inhibition limited cell proliferation and the expression of proteins in JAK-STAT3 signaling pathway. All in all, LINC00473 contributed to cell proliferation via JAK-STAT3 signaling pathway by regulating miR-195-5p/SEPT2 axis in prostate cancer, which provided a novel therapeutic tactic for prostate cancer patients. Yes In the present study, we discovered that prostate cancer cells presented high expression of LINC00473, and LINC00473 inhibition limited cell proliferation and the expression of proteins in JAK-STAT3 signaling pathway. 32440687 LINC00473 LncRNA Homo sapiens Molecular Epidemiology IPA tissues Interaction(miR-502-3p/KMT5A/cyclin D1 and CDK2) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RNA-seq//Luciferase Report Assay//IHC//EdU Staining In our study, LINC00473 was identified as the most upregulated lncRNA in IPA by whole transcriptome RNA sequencing (RNA-Seq). LINC00473 is overexpressed in IPA and can promote PA cells proliferation. Mechanistically, overexpression of LINC00473 restricts miR-502-3p through the ceRNA mechanism, upregulates KMT5A expression, and promotes the expression of cyclin D1 and CDK2, which is conducive to the cell cycle process, thereby promoting the proliferation of PA cells, involving IPA progression. Yes LINC00473 is overexpressed in IPA and can promote PA cells proliferation. 34091587 LINC00924 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(hnRNPC/Mnk2 ) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Colony Formation Assay//Invasion Assay//Transwell Assay LINC00924 was highly expressed in GC, and its high expression is associated with a broad range of PM. Regarding the mechanism, LINC00924 regulated the alternative splicing (AS) of Mnk2 pre-mRNA by binding to hnRNPC. Specifically, LINC00924 enhanced the binding of hnRNPC to Mnk2 pre-mRNA at e14a, thus downregulating Mnk2a splicing and regulating the p38 MAPK/PPARα signaling pathway. Yes Via RNA sequencing, RNA pulldown assay, mass spectrometry, Seahorse, Lipidomics, spheroid formation and cell viability assays, we found that LINC00924 promoted fatty acid (FA) oxidation (FAO) and FA uptake, which was essential for matrix-detached GC cell survival and spheroid formation. 36418856 LINC00930 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction(PFKFB3/RBBP5 and GCN5) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//qPCR//Co-IP//CCK8//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//ChIP In this study, we identified and functionally characterized a novel metabolism-related lncRNA, LINC00930, which was upregulated and associated with tumorigenesis, lymphatic invasion, metastasis, and poor prognosis in nasopharyngeal carcinoma (NPC). Mechanistically, LINC00930 served as a scaffold to recruit the RBBP5 and GCN5 complex to the PFKFB3 promoter and increased H3K4 trimethylation and H3K9 acetylation levels in the PFKFB3 promoter region, which epigenetically transactivating PFKFB3, and thus promoting glycolytic flux and cell cycle progression. In this study, we identified and functionally characterized a novel metabolism-related lncRNA, LINC00930, which was upregulated and associated with tumorigenesis, lymphatic invasion, metastasis, and poor prognosis in nasopharyngeal carcinoma (NPC). Yes Functionally, LINC00930 was required for increased glycolysis activity and cell proliferation in multiple NPC models in vitro and in vivo. 35209949 LINC00941 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC cells Regulation(Cadherin 6) Western Blot//Transfection//Flow Cytometry//qRT-PCR//RNA-seq//Cell Proliferation Assay//ChIP-seq//Invasion Assay//IF Linc00941 expression was significantly higher in aggressive cancer both in the TCGA dataset and in a separate validation cohort from our institution. Loss of function assays for linc00941 showed that it promotes response to stimuli and invasiveness while restraining proliferation in PTC cells, a typical phenotype of metastatic cells. From the integration of TCGA data and linc00941 knockdown RNA-seq profiling, we identified 77 genes under the regulation of this lncRNA. Among these, we found the prometastatic gene CDH6. Linc00941 knockdown partially recapitulates the effects observed upon CDH6 silencing, promoting cell cytoskeleton and membrane adhesions rearrangements and autophagy. The combined expression of CDH6 and linc00941 is a distinctive feature of highly aggressive PTC lesions. Yes Loss of function assays for linc00941 showed that it promotes response to stimuli and invasiveness while restraining proliferation in PTC cells, a typical phenotype of metastatic cells. 32495722 LINC01535 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cells Interaction(LINC01535/miR-146b-5p/TRIM2 axis ) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay This study showed downregulation of LINC01535 in ccRCC.Furthermore, LINC01535 sponged miR-146b-5p which had a negative correlation with LINC01535, and TRIM2 was a direct target of miR-146b-5p and mediated by LINC01535. Mechanically, LINC01535/miR-146b-5p/TRIM2 axis affected ccRCC progression by mediating the PI3K/Akt signaling. Yes Moreover, LINC01535 upregulation attenuated in vitro ccRCC development and hindered in vivo tumor growth. 35342411 LINC01518 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma Regulation[PIK3CA/Akt pathway ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay We found that LINC01518 expression was upregulated and miR-1-3p expression was downregulated in ESCC cells.In conclusion, LINC01518 knockdown inhibited tumorigenicity in ESCC cells by suppression of PIK3CA/Akt pathway through upregulating miR-1-3p. Yes LINC01518 knockdown inhibited cell proliferation and promoted apoptosis in ESCC cells. 31810385 LINC01515 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction(miR-325/CDCA5 pathway) IHC//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LINC01515 expression was increased in NPC and that high LINC01515 expression was associated with a worse prognosis. Mechanistically, LINC01515 facilitated cell division cycle associated 5 (CDCA5) expression via serving as a sponge for miR-325. And more notably, miR-325 suppressed NPC progression in vitro by targeting CDCA5. LINC01515 expression was increased in NPC and that high LINC01515 expression was associated with a worse prognosis. Yes Functionally, depletion of LINC01515 resulted in an inhibition of cell proliferation, migration and invasion, while apoptosis was promoted. 33770322 LINC01503 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues interaction[Wnt Signaling] qRT-PCR//Western Blot//Transwell Assay LINC01503 was highly expressed in gastric cancer tissues and cell lines, which was correlated with poor prognosis.This research reported that the elevated expression of LINC01503 could promote proliferation and metastasis of gastric cancer through positively regulating the Wnt/β-catenin pathway. LINC01503 was highly expressed in gastric cancer tissues and cell lines, which was correlated with poor prognosis. Yes Knockdown of LINC01503 suppressed gastric cancer cell proliferation and invasion, whereas overexpression of LINC01503 showed a reverse trend. 32207034 LINC01503 LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[ DUSP5/CDKN1A] qRT-PCR//FISH//RIP//ChIP Linc01503 was remarkably elevated in GC and tightly linked with the overall survival of patients with GC. EGR1-activated linc01503 could epigenetically silence DUSP5/CDKN1A expression to mediate cell cycle progression and tumorigenesis, implicating it as a prospective target for GC therapeutics. Linc01503 was remarkably elevated in GC and tightly linked with the overall survival of patients with GC. Yes Functionally, linc01503 knockdown resulted in the activation of apoptosis and G1/G0 phase arrest in GC. 33145887 LINC01503 LncRNA Homo sapiens Carcinoma, Hepatocellular regulation[MAPK/ERK pathway] CCK8//qRT-PCR//Flow Cytometry LINC01503 was highly expressed in HCC and positively correlated with large tumor size, high tumor grade, advanced tumor stage, and poor prognosis of HCC patients.LINC01503 is highly expressed in HCC and promotes the progression of HCC via MAPK/ERK pathway, which maybe a new potential biomarker and therapeutic target for HCC. LINC01503 was highly expressed in HCC and positively correlated with large tumor size, high tumor grade, advanced tumor stage, and poor prognosis of HCC patients. Yes Silencing LINC01503 with shRNA significantly restrained the proliferation of MHCC-97H HCC cells and strengthened the apoptosis, while up-regulation of LINC01503 in Huh7 HCC cells contributed to the contrary effects. 32547318 LINC01503 LncRNA Homo sapiens Glioma glioma tissue and cell lines Interaction[Wnt/β-catenin pathway] qRT-PCR//Western Blot We found that LINC01503 expression level was significantly up-regulated in glioma tissue and cells.Mechanistic investigation showed that LINC01503 can modulate Wnt/β-catenin signaling, as determined by that knockdown of LINC01503 decreased the TOP-FLASH activity and β-catenin, cyclin D1 and c-myc. We found that LINC01503 expression level was significantly up-regulated in glioma tissue and cells, and that its overexpression was significantly correlated with KPS, tumor size and WHO grade in glioma patients. Kaplan-Meier analysis showed that patients with higher levels of LINC01503 had significantly poorer overall survival and disease-free survival than those with lower expression of this lncRNA in glioma patients. Yes Functional assays with in vitro showed that knockdown of LINC01503 in the U251 and LN299 cell lines suppressed cells growth, colony formation, invasion and migration, and promoted apoptosis. 30840283 LINC01503 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues regulation[ SFPQ-FOSL1 axis] ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Colony Formation Assay//Transwell Assay Here, we verified that LINC01503 was highly expressed in NPC and correlated with poor prognosis.Taken together, our findings reveal that AR-induced LINC01503 can promote NPC progression through the SFPQ-FOSL1 axis, which represents a novel prognostic biomarker and therapeutic target for NPC patients. Here, we verified that LINC01503 was highly expressed in NPC and correlated with poor prognosis. Yes LINC01503 promoted NPC cell proliferation, migration, and invasion in vitro, and facilitated tumor growth and metastasis in vivo. 32661324 LINC01503 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC samples and cell lines interaction[miR-342-3p] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//EdU Staining//Transwell Assay We demonstrated that the expression of lncRNA LINC01503 and LIM and SH3 domain protein 1 (LASP1) were upregulated and miR-342-3p was downregulated in NSCLC samples and cell lines. In addition, LINC01503 could bind to miR-342-3p and affect the expression of LASP1. Yes Functional experiments revealed that inhibiting the expression of LINC01503 or over-expression of miR-342-3p inhibited NSCLC growth and metastasis both in vitro and in vivo. 32938459 LINC01503 LncRNA Homo sapiens gastric cardia adenocarcinoma GCA tissues and cell lines regulation[miR-133a-5p/VIM Axis and EMT Process] qRT-PCR//Luciferase Report Assay//RIP The expression level of LINC01503 was significantly elevated in GCA tissues and cell lines. LINC01503 serves as an oncogenic lncRNA to promote GCA progression via affecting LINC01503/miR-133a-5p/VIM axis and EMT process. High expression of LINC01503 was correlated with lymph node metastasis, TNM stage, and poor prognosis of GCA patients. Yes Knockdown of LINC01503 significantly reduced proliferation, migration, and invasion ability in GC cells. 33200343 LINC01494 LncRNA Homo sapiens Glioma glioma tissue Regulation[LINC01494/miR-122-5p/CCNG1 signaling ] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay LINC01494 was identified as a significantly upregulated lncRNA in glioma through bioinformatics analysis.Rescue assay further demonstrated that LINC01494/miR-122-5p/CCNG1 signaling cascade plays a critical role in regulating glioma cell proliferation, migration and invasion.  Furthermore, LINC01494 upregulation indicated poor prognosis.  Yes Meanwhile, in vitro investigation indicated that silencing LINC01494 with siRNAs obviously inhibited the proliferation, cell cycle, migration and invasion of glioma cells. 31571916 LINC01485 LncRNA Homo sapiens Stomach Neoplasms gastric tissues regulation[EGFR/Akt Signaling] RNA Pull-Down//Wound Healing Assay//qRT-PCR//FISH//Transwell Assay LINC01485 was upregulated and associated with tumor size, lymphatic metastasis and advanced pathological stage in gastric cancer. LINC01485 promoted EGFR stabilization and activation of EGFR/Akt signaling in gastric cancer. LINC01485 was upregulated and associated with tumor size, lymphatic metastasis and advanced pathological stage in gastric cancer. Yes LINC01485 promoted gastric cancer cell proliferation, migration and invasion in vitro and in vivo. 32904620 LINC01480 LncRNA Homo sapiens Coronary Artery Disease CAD samples Regulation Bioinformatics Analysis The immune cell infiltration analysis of ischemic cardiomyopathy (ICM; an advanced stage of CAD) samples revealed that the proportion of macrophage M2 was upregulated in the LINC01480 highly expressed samples, thus suggesting that LINC01480 plays a protective role in the progression of ICM. Yes The immune cell infiltration analysis of ischemic cardiomyopathy (ICM; an advanced stage of CAD) samples revealed that the proportion of macrophage M2 was upregulated in the LINC01480 highly expressed samples, thus suggesting that LINC01480 plays a protective role in the progression of ICM. 35557532 LINC01451 LncRNA Homo sapiens Urinary Bladder Neoplasms BLCa tissues Interaction(LIN28/TGF-β/Smad pathway) qRT-PCR//ChIP//Western Blot LINC01451 was identified a novel functional lncRNA, whose expression level in BLCa tissues was significantly higher compared with the normal tissues. Mechanistically, LINC0145 was shown to depend on LIN28A and LIN28B, facilitated epithelial-mesenchymal transition (EMT) through activating the TGF-β/Smad signaling pathway, which subsequently aggravated BLCa progression. Yes Furthermore, it was found that LINC01451 directly docked LIN28A and LIN28B, and promoted the proliferation, invasion, and metastasis of BLCa. 33516780 LINC01448 LncRNA Homo sapiens Pancreatic Neoplasms Interaction(miR-505) Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay LINC01448 was identified as an oncogenic lncRNA that could reduce miR-505 expression. Subsequent studies confirmed that LINC01448 enhanced cell proliferation, invasion, sphere formation, glucose consumption, and lactate production by regulating the miR-505/HK2 pathway. Yes Subsequent studies confirmed that LINC01448 enhanced cell proliferation, invasion, sphere formation, glucose consumption, and lactate production by regulating the miR-505/HK2 pathway. 33520999 LINC01446 LncRNA Homo sapiens Glioblastoma GBM tissues Regulation[miR-489-3p/TPT1 axis] Western Blot//Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay//Transwell Assay Our study revealed a novel lncRNA LINC01446 whose expression was elevated in GBM tissues.Taken together, this study demonstrates a novel singling pathway of LINC01446/miR-489-3p/TPT1 cascade that regulates GBM progression. Besides, high expression of LINC01446 indicated a poor prognosis in GBM patients. Yes Functionally, LINC01446 knockdown dramatically inhibited GBM cell proliferation, arrested cell-cycle progression and attenuated invasion in vitro. Furthermore, the xenograft mouse model showed that LINC01446 silence led to impaired tumor growth in vivo. 30029885 LINC01436 LncRNA Homo sapiens Stomach Neoplasms cancerous tissues of GC samples regulation[ miR-585 and FBXO11] qRT-PCR We demonstrated that LINC01436 was significantly up-regulated in cancerous tissues of GC samples, and its overexpression was correlated with a worse prognosis for the patients.Collectively, these results suggested that LINC01436 was an oncogenic lncRNA in GC and promoted proliferation and metastasis of GC cell via regulating miR-585 and FBOX11. Yes In the GC cell line BGC823 cells, LINC01436 knockdown repressed the proliferation and metastasis of cancer cells; conversely, in GC cell line AGS cells, overexpression of LINC01436 showed the opposite effects. 31829474 LINC01526 LncRNA Homo sapiens Stomach Neoplasms gastric cancer cells and tissues Interaction(TARBP2/GNG7 ) RNA Pull-Down//Western Blot//CCK8//FISH//qRT-PCR//RIP//RNA-seq//Transwell Assay//IF We found that LINC01526 was upregulated in gastric cancer cells and tissues. Furthermore, LINC01526 interacted with TAR (HIV-1) RNA-binding protein 2 (TARBP2) and decreased the mRNA stability of G protein gamma 7 (GNG7) through TARBP2. Finally, the rescue assay showed that downregulating GNG7 partially rescued the cell proliferation inhibited by LINC01526 or TARBP2 silencing. Yes The function experiments in vitro and the Xenograft mouse model in vivo proved that LINC01526 could promote gastric cancer cell proliferation and migration. 36230863 LINC01535 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction[miR‐214/EZH2] RNA Pull-Down//IHC//Western Blot//qRT-PCR//Luciferase Report Assay//Transwell Assay//ChIP Clinically, LINC01535 is significantly up-regulated in cervical cancer tissues and correlated with advanced clinical stage and poor prognosis. Activation of the miR-214/EZH2 regulatory loop by overexpression of miR-214 or silencing of EZH2 reverses the roles of LINC01535 in promoting cervical canc`er cell growth, migration and invasion in vitro and cervical cancer xenograft growth in vivo. Clinically, LINC01535 is significantly up-regulated in cervical cancer tissues and correlated with advanced clinical stage and poor prognosis. Yes Functional experiments showed that enhanced expression of LINC01535 promotes cervical cancer cell growth, migration and invasion in vitro and cervical cancer xenograft growth in vivo. Reciprocally, LINC01535 knockdown suppresses cervical cancer cell growth, migration and invasion. 31273925 LINC01436 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-466) qRT-PCR//RNA Pull-Down//Luciferase Report Assay LINC 01436 was upregulated in CRC and predicted poor survival. LINC 01436 was inversely correlated with mature miR-466, but not miR-466 precursor. LINC 01436 was predicted to bind with miR-466 precursor. Their interaction was further verified by dual-luciferase activity assay. In CRC cells, LINC 01436 overexpression downregulated mature miR-466 but not miR-466 precursor. LINC 01436 was upregulated in CRC and predicted poor survival. Yes Cell proliferation analysis showed that LINC 01436 overexpression rescued cell proliferation reduced by miR-466. LINC 01436 is overexpressed in CRC and promotes cancer cell proliferation by suppressing miR-466 maturation. 35171402 LINC01535 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines regulation[miR-214-3p/KCNC4 Axis] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay The high expression of LINC01535 was presented in OS tissues and cell lines compared with adjacent normal tissues and human osteoblasts. LINC01535, miR-214-3p and KCNC4 constituted an effective axis that exerted a pregnant regulation in OS development, which is a quite meaningful discovery for exploring potential therapeutic methods for OS patients. Moreover, OS patients with high LINC01535 expression exhibited poor prognosis. Yes Loss-of-function assay revealed that silenced LINC01535 significantly attenuated cell proliferation, migration and invasion, and enhanced cell apoptosis in OS. 32753970 LINC01606 LncRNA Homo sapiens Colonic Neoplasms colon cancer cell and tissues Interaction( SCD1-Wnt/β-catenin-TFE3 feedback loop signalling) qRT-PCR//RIP//Transwell Assay The expression of lncRNA LINC01606 was frequently upregulated in human colon cancer and strongly associated with a poor prognosis. Mechanistically, LINC01606 enhanced the expression of stearoyl-CoA desaturase 1 (SCD1), serving as a competing endogenous RNA to modulate miR-423-5p expression, subsequently activating the canonical Wnt/β-catenin signaling, and transcription factor binding to IGHM enhancer 3 (TFE3) increased LINC01606 transcription after recruitment to the promoter regions of LINC01606. The expression of lncRNA LINC01606 was frequently upregulated in human colon cancer and strongly associated with a poor prognosis. Yes LINC01606 functioned as an oncogene and promotes colon cancer cell growth, invasion and stemness both in vitro and in vivo. Moreover, LINC01606 protected colon cancer cells from ferroptosis by decreasing the concentration of iron, lipid reactive oxygen species, mitochondrial superoxide and increasing mitochondrial membrane potential. 35485210 LINC01605 LncRNA Homo sapiens Colorectal Neoplasms CC tissues Interaction(METTL3 and SPTBN2.) RIP//MeRIP//RNA Pull-Down//Luciferase Report Assay LINC01605, significantly highly expressed in CC, was a prognostic factor for patients with CC.Moreover, LINC01605 was regulated by SMYD2-EP300-mediated modifications of histone H3K4me3 as well as H3K27ac. Yes Functional experiments revealed that LINC01605 knockdown inhibited the proliferatory and metastatic potential of CC cells in vitro and in vivo. 34544413 LINC01585 LncRNA Homo sapiens Breast Neoplasms BC tissues Regulation[CAMP/CREB signaling pathway] RNA Pull-Down//CCK8//FISH//qRT-PCR//Cell Cycle Assay//Colony Formation Assay Here, we report a novel lncRNA, LINC01585, is aberrantly down regulated during breast cancer (BC). Mechanistically, LINC01585 was located in nuclear and binding with NONO protein. Interestingly, when LINC01585 was down-expressed, NONO separated from LINC01585 and then interacted with CRTC. The complex promotes CAMP/CREB target gene transcription and thus promotes the growth of breast cancer. Yes Functionally, we found that LINC01585 overexpression inhibited breast cancer proliferation and growth by prototypical experiments. 30366079 LINC01572 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-195-5p/PFKFB4 ) RNA Pull-Down//CCK8//qRT-PCR//RIP//Colony Formation Assay//Transwell Assay In this study, we profiled lncRNAs in HCC tissues and corresponding adjacent tissues from HCC patients with T2DM by RNA sequencing. Our data showed that LINC01572 was aberrantly upregulated in HCC tissues as compared with control, especially in those with concurrent T2DM. A mechanistic study revealed that LINC01572-regulated HCC progression via sponging miR-195-5p to increase the level of PFKFB4 and subsequent enhancement of glycolysis and activation of PI3K-AKT signaling. The high level of LINC01572 was correlated with advanced tumor stage, increased blood HbA1c level, and shortened survival time. Yes The overexpression of LINC01572 significantly promoted HCC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT), while the knockdown of LINC01572 had the opposite effects on HCC cells. 34970545 LINC01572 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cell lines Regulation CCK8//qRT-PCR//Transfection//EdU Staining Then, we successfully created a risk model according to five ferroptosis-associated lncRNAs (LINC00472, MBNL1-AS1, LINC01572, ZFPM2-AS1, and TMPO-AS1). Our nominated model had good stability and predictive function. The expression patterns of five ferroptosis-associated lncRNAs were confirmed by polymerase chain reaction (PCR) in LUAD cell lines. Yes Knockdown of LINC01572 significantly inhibited cell viability and induced ferroptosis in LUAD cell lines. 36686701 LINC01569 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-381-3p/RAP2A Axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay LINC01569 expression was distinctly increased in CRC. Yes Curiously, if LINC01569 is removed, CRC cells will not migrate, proliferate, and invade remarkably. 34422671 LINC01564 LncRNA Homo sapiens Stomach Neoplasms GC cells Regulation(POU2F1 ) RNA Pull-Down//IHC//ChIP//Western Blot//qRT-PCR//FISH//RIP//MTT//Colony Formation Assay//Invasion Assay//IF The results showed that LINC01564 complementary bound to the 3'UTR of POU2F1 to form an RNA duplex, whereby stabilizing POU2F1 mRNA and increasing the enrichment in cells. The level of LINC01564 was also increased by POU2F1 through transcription activation. In vitro assays showed that LINC01564 promoted the proliferation, invasion and migration of GC cells through increasing POU2F1. In vivo experiments indicate the promotion of GC proliferation and metastasis by the interaction between LINC01564 and POU2F1. Yes In vitro assays showed that LINC01564 promoted the proliferation, invasion and migration of GC cells through increasing POU2F1. In vivo experiments indicate the promotion of GC proliferation and metastasis by the interaction between LINC01564 and POU2F1. 35562740 LINC01561 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines interaction[SHCBP1,miR-760] qRT-PCR In this study, we first provided evidence that LINC01561 expressions were distinctly upregulated in NSCLC tissues and cell lines. In summary, our findings indicated that SOX2-induced overexpression of LINC01561 promoted the proliferation and metastasis by acting as a competing endogenous RNA to modulate SHCBP1 by sponging miR-760. Clinical research revealed that upregulation of LINC01561 was related to poorer clinicopathologic features and shorter survival time. Yes Functionally, suppression of LINC01561 exhibited tumor-suppressive functions through impairing cell proliferation, migration, and invasion as well as inducing apoptosis. 32003010 LINC01559 LncRNA Homo sapiens Breast Neoplasms TNBC tissues Interaction(miR-370-3p/miR-485-5p/miR-940) Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay//EdU Staining//ChIP LINC01559 was significantly increased in TNBC tissues as compared to matched normal tissues, which was due to high levels of H3K4Me3 and H3K27Ac in the promoter region. Mechanistically, LINC01559 served as a ceRNA that sponged miR-370-3p, miR-485-5p and miR-940, resulting in increasing the expression of a cohort of oncogenes, thus accelerating TNBC progression. Yes Knockdown of LINC01559 inhibited TNBC cell proliferation, migration and invasion in vitro, and also retarded tumor growth and reduced lung metastasis in vivo. 35715331 LINC01559 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC patient Interaction(miR-511/SLC38A1 ) CCK8//qRT-PCR//Transwell Assay//Western Blot LINC01559 was highly expressed, and related to poor prognosis in HCC patients. Furthermore, LINC01559 can function as a sponge for miR-511, which was downregulated in HCC patients. Downregulation of miR-511 significantly increased the cell viability, invasive and migratory capacities, and could abolish the suppressive effect of LINC01559-knockdown on these HCC cells. Moreover, SLC38A1 was a target of miR-511 and upregulated in HCC. K LINC01559 was highly expressed, and related to poor prognosis in HCC patients. Yes LINC01559-knockdown restrained the proliferation and growth of HepG2 and Huh7 cells. 33588099 LINC01559 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic tissues ,cell lines Interaction[YAP-mediated pathway] qRT-PCR Further, our results showed that LINC01559 was stimulated in PC cell lines relative to normal controls. Collectively, our findings unmasked that LINC01559 accelerates PC progression through relying on YAP, providing a new potential target for clinical treatment of patients with PC. Yes Furthermore, we validated that LINC01559 facilitated PC cell proliferation and migration in vitro. Also, silencing LINC01559 obstructed PC cell growth in vivo. 31608998 LINC01559 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Expression [highly expressed] Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//IF//Cell Proliferation Assay//Bioinformatics Analysis//Transwell Assay We found high expression of LINC01559 indicates lymph node metastasis and poor prognosis. Yes Besides, LINC01559 promotes lung cancer cell proliferation and migration in vitro, by enhancing autophagy signal pathway via sponging hsa-miR-1343-3p. 34823534 LINC01555 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The Cancer Genome Atlas (TCGA) dataset showed that LINC01555 was highly expressed in CRC tissue when compared with adjacent normal colorectal tissue. LINC01555 expression was positively correlated with tumor stage, but negatively correlated with disease-free survival (DFS) and overall survival (OS) and was an independent risk factor for CRC. Yes Knockdown of LINC01555 inhibited cell proliferation, migration, and invasion of CRC cells. Functional studies showed that knockdown of NmU reduced cell migration and invasion of CRC cells that overexpressed LINC01555. 31144675 LINC01555 LncRNA Homo sapiens Small Cell Lung Carcinoma SCLC tissues and cells Interaction(microRNA-122-5p/clic1 axis ) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay Linc01555 was elevated in SCLC tissues and cells, and in H446/DDP cells or DMS-53/DDP vs. its parental cells; Restraining linc01555 or elevating miR-122-5p repressed the proliferation and metastasis of H446/DDP or DMS-53/DDP cells and vasculogenic mimicry (VM) formation. CLIC1 mediated miR-122-5p to influence the occurrence and development of SCLC. Linc01555 competitively combined with miR-122-5p, which targeted CLIC1. Yes Linc01555 was elevated in SCLC tissues and cells, and in H446/DDP cells or DMS-53/DDP vs. its parental cells; Restraining linc01555 or elevating miR-122-5p repressed the proliferation and metastasis of H446/DDP or DMS-53/DDP cells and vasculogenic mimicry (VM) formation. 36045598 LINC01554 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[ Akt/mTOR Signaling Pathway] RNA Pull-Down//Northern Blot//Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay LINC01554 was frequently downregulated in HCC, which was significantly associated with tumor invasion (P = 0.005), tumor size (P = 0.041), tumor staging (P = 0.023) and shorter survival (P = 0.035) of HCC patients.LINC01554 promoted the ubiquitin-mediated degradation of PKM2 and inhibited Akt/mTOR signaling pathway to abolish aerobic glycolysis in HCC cells. Further study found that LINC01554-knockout could effectively reverse the tumor-suppressive effect of LINC01554. LINC01554 was frequently downregulated in HCC, which was significantly associated with tumor invasion (P = 0.005), tumor size (P = 0.041), tumor staging (P = 0.023) and shorter survival (P = 0.035) of HCC patients. Yes Ectopic expression of LINC01554 inhibited HCC cell growth, colony formation in soft agar, foci formation, and tumor formation in nude mice. 30809309 LINC01550 LncRNA Homo sapiens Melanoma melanoma tissues Expression(lower expressed) qRT-PCR//MTT//Cell Cycle Assay//Transwell Assay We found that lncRNA LINC01550 was significantly down-regulated in the melanoma tissues as compared to the normal tissues. The low expression of LINC01550 was tightly associated with shorter overall survival and disease-free survival of patients with melanoma. Yes LINC01550 expression is negatively associated with tumor cell proliferation and invasion abilities in melanoma as evidenced by the single-cell RNA sequencing (scRNA-seq) databases. Up-regulation of LINC01550 significantly inhibited proliferation and invasion abilities, as well as induced cell apoptosis and G1 and S phase arrest of the melanoma cells. 33609219 LINC01546 LncRNA Homo sapiens Stomach Neoplasms GCs Interaction(PKM2 ) RNA Pull-Down//Co-IP//CCK8//qRT-PCR//RIP//FISH//Transwell Assay Long non-coding RNA (lncRNA) VAL is significantly upregulated in GCs and indicates poor prognosis. Mechanistically, VAL strengthens the enzymatic activity of PKM2 and aerobic glycolysis of GC cells through directly binding with PKM2 to abrogate the PKM2-Parkin interaction, and to suppress Parkin-induced polyubiquitination of PKM2. Long non-coding RNA (lncRNA) VAL is significantly upregulated in GCs and indicates poor prognosis. Yes Functional assays showed that VAL promotes GC malignant progression. 36229913 LINC01537 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(RIPK4/TRIM25/RIPK4 ) RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//RIP//Colony Formation Assay LINC01537 was significantly overexpressed in GC tissues and associated with a poor prognosis. Mechanistically, LINC01537 stabilizes RIPK4 by reducing the binding of RIPK4 to TRIM25 and reducing its ubiquitination degradation, thereby promoting the expression of the NF-κB signaling pathway. According to our findings, the LINC01537-RIPK4-NF-κB axis promoted GC metastasis and tumorigenesis. LINC01537 was significantly overexpressed in GC tissues and associated with a poor prognosis. Yes Functional experimental results revealed that LINC01537 promoted the proliferation, invasion, and migration of GC cells. The animal experiments revealed that LINC01537 promoted tumorigenesis and metastasis in vivo. 36358656 LINC01535 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-761) qRT-PCR//Luciferase Report Assay//RIP LINC01535 expression was observed to be upregulated in CRC tissues and cell lines. A luciferase reporter assay demonstrated that LINC01535 regulated miR-761 directly and RNA-binding protein immunoprecipitation further confirmed that the suppression of LINC01535 by miR-761 was via an RNA-induced silencing complex. Yes A functional study suggested that LINC01535 silencing inhibited CRC cell proliferation and invasion but enhanced cisplatin sensitivity of CRC cells, while co-transfection with a miR-761 inhibitor reversed these biological effects. 33986850 LINC01436 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[targeting miR-30a-3p ] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Microarray//ChIP Here, we identified a novel up-regulated lncRNA, LINC01436 (RefSeq: NR_110419.1), in non-small cell lung cancer (NSCLC). Mechanistically, LINC01436 exerted biological functions by acting as a microRNA (miR)-30a-3p sponge to regulate the expression of its target gene EPAS1. Our findings characterize LINC01436 as a new hypoxia-sensitive lncRNA with oncogenic function in NSCLC, suggesting that LINC01436 may be a potential biomarker for prognosis and a potential target for treatment. High expression of LINC01436 was significantly associated with poor overall survival. Yes Gain- and loss-of-function studies revealed that LINC01436 acted as a proto-oncogene by promoting lung cancer cell growth, migration and invasion in vitro. Xenograft tumor assays in nude mice confirmed that LINC01436 promoted tumor growth and metastasis in vivo. 30614188 LINC01433 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells interaction[sponging miR-1301] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay Linc01433 was abnormally up-regulated in ESCC tissues and cells. Linc01433 participated in ESCC progression by regulating miR-1301 and it could function as a novel biomarker in ESCC diagnosis and treatment. High level of linc01433 was positively correlated with tumor size and lymph node metastasis in ESCC patients. Yes Up-regulation of linc01433 promoted cell proliferation and migration. 32432741 LINC00941 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(TGF-β/SMAD2/3 axis) RNA Pull-Down//Western Blot//ISH//Co-IP//RIP//qRT-PCR//IP//IHC LINC00941 was shown to be upregulated in CRC, and upregulated LINC00941 was associated with poor prognosis. Our data reveal the essential role of LINC00941 in metastatic CRC via activation of the TGF-β/SMAD2/3 axis, which provides new insight into the mechanism of metastatic CRC and a novel potential therapeutic target for advanced CRC. LINC00941 was shown to be upregulated in CRC, and upregulated LINC00941 was associated with poor prognosis. Yes Functionally, LINC00941 promoted migratory and invasive capacities and accelerated lung metastasis in nude mice. 32737443 LINC01348 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(SF3B3/EZH2/JNK/c-Jun/Snail ) qRT-PCR In this study, we identified a novel lncRNA, LINC01348, which was significantly downregulated in HCC and correlated with survival functions in HCC patients. Our data collectively highlight those novel regulatory associations involving LINC01348/SF3B3/EZH2/JNK/c-Jun/Snail are an important determinant of metastasis in HCC cells and support the potential utility of targeting LINC01348 as a therapeutic strategy for HCC. In this study, we identified a novel lncRNA, LINC01348, which was significantly downregulated in HCC and correlated with survival functions in HCC patients. Yes Ectopic expression of LINC01348 induced marked inhibition of cell growth, and metastasis in vitro and in vivo. 34140643 LINC01320 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell strains Interaction( miR-324-3p) Transfection//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay We conclude that LINC01320 is highly expressed in PC tissues and cell strains.In addition, LINC01320 is expressed by miR-324-3p, which is also supported by in vivo experiments. LINC01320 high expression was bound up with a poor prognosis. Yes LINC01320 gene knockout inhibited the growth, migration, and invasiveness of PC cells. 34976325 LINC01315 LncRNA Homo sapiens Breast Neoplasms TNBC tissues Interaction(microRNA-876-5p/GRK5) qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay A significant upregulation of LINC01315 was observed in TNBC, which was associated with disease development and severity of patients. Additionally, miR-876-5p was demonstrated to be a target of LINC01315 and regulate the expression of GRK5, through which LINC01315 modulated the progression of TNBC. The upregulation of LINC01315 could be a symptom of the poor prognosis of patients. Yes The knockdown of LINC01315 suppressed the main cellular processes of TNBC progression. 35412954 LINC01315 LncRNA Homo sapiens Colorectal Neoplasms CRC and ALDH+ cells Interaction(miR-484/DLK1 axis) qRT-PCR//Luciferase Report Assay//Western Blot LINC01315 was high-expressed in CRC and ALDH+ cells. Yes LINC01315 silencing suppressed the migration, invasion, and sphere formation of CRC cells and tumor growth, and downregulated expressions of CSC molecules (ALDH, cluster of difference 44 (CD44), Prominin, and sex determining region Y-box 2 (SOX2)), Zinc Finger E-Box Binding Homeobox 1 (ZEB1) and Vimentin but upregulated E-Cadherin expression. 35156543 LINC01315 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells interaction[binding to miR-211] Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay LINC01315 and DLG3 were determined to be poorly expressed while microRNA-211 (miR-211) was highly expressed in OSCC tissues and cells using RT-qPCR and western blot analysis. These findings suggest that LINC01315 elevates DLG3 expression by competitively binding to miR-211, thereby suppressing OSCC progression. Yes Upon altering the expression of LINC01315, and/or miR-211 in OSCC cells with shRNA, mimic, or an inhibitor, we assessed their effects on OSCC cell proliferation, migration, invasion, and apoptosis. LINC01315 knockdown enhanced OSCC cell proliferation, migration and invasion, but dampened their apoptosis, all of which could be reversed by miR-211 inhibition. 33117688 LINC01311 LncRNA Homo sapiens Thyroid Neoplasms TC cells and tissues Interaction(miR-146b-5p/IMPA2 axis) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay The TC cells and tissues exhibited a downregulation of LINC01311 and IMPA2 and an upregulation of miR-146b-5p. The luciferase reporter and RIP assays verified that miR-146b-5p recognizes LINC01311 and IMPA2 3'UTR by base pairing. Yes LINC01311 overexpression retarded TC cell growth in vitro as well as in vivo. 36423383 LINC01311 LncRNA Homo sapiens Alzheimer Disease SH-SY5Y cells Interaction( hsa-miR-146a-5p) qRT-PCR//Luciferase Report Assay LINC01311 was downregulated whereas hsa-miR-146a-5p upregulated in AB1-42 treated SH-SY5Y cells. Our work demonstrated that the epigenetic axis of LINC01311/hsa-miR-146a-5p was involved in the functional regulation of human-lineage neurons in a cellular model of AD, thus suggesting a clinical potential of exploring epigenetic network for treating AD patients. Yes LINC01311 upregulation and hsa-miR-146a-5p downregulation protected AB1-42-induced apoptosis, proliferation slowdown, autophagy, and APP accumulations in SH-SY5Y cells. Hsa-miR-146a-5p overexpression reversed the protection of LINC01311 on AB1-42-induced neural injuries. 33830627 LINC01305 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines regulation[miR-129-5p/Sox4 axis] RNA Pull-Down//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of LINC01305 was evidently elevated in CC tissues and cell lines than that in controls and associated with clinicopathological features. LINC01305 acts as a competitive endogenous RNA (ceRNA) and regulates Sox4 via sponging miR-129-5p, contributing to the diagnosis and treatment of CC. The expression of LINC01305 was evidently elevated in CC tissues and cell lines than that in controls and associated with clinicopathological features. Yes Downregulating LINC01305 suppressed malignant phenotypes (proliferation, migration, invasion) of Hela and SiHa cells. 33312390 LINC01305 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tumor tissues Regulation(KHSRP ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tunel//Flow Cytometry//qRT-PCR//FISH//RIP//IHC The results showed that LINC01305 was increased in CC tumor tissues and was correlated with a lower survival rate. Moreover, the effect of LINC01305 on CC was mediated through interacting with the RNA-binding protein, KHSRP. Furthermore, LINC01305 was mainly distributed in exosomes and was transferred to recipient cells to enhance CC progression. The overexpression and knockdown of LINC01305 enhanced and inhibited the progression of CC, respectively. Yes The overexpression and knockdown of LINC01305 enhanced and inhibited the progression of CC, respectively. Additionally, the upregulation of LINC01305 promoted tumor growth in xenograft mice. 33638945 LINC01303 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction[sponging miR-101-3p] CCK8 In our study, we found that the expression of LINC01303 was significantly higher in GC tissues than in adjacent tissues by real-time quantitative PCR. After the bioinformatics analysis, we found that LINC01303 can be used as a miR-101-3p sponge to competitively adsorb miR-101-3p with EZH2. Therefore, our results indicate that LINC01303 promotes the expression of EZH2 by inhibiting miR-101-3p activity and promotes GC progression. Yes We can significantly inhibit the malignant proliferation, migration and invasion of GC cells by silencing LINC01303 expression. In addition, LINC01303 knockdown can also inhibit GC growth in vivo. 31497936 LINC01303 LncRNA Homo sapiens laryngeal carcinoma LSCC tissues Interaction(miR-200c/TIMP2 axis) Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//ChIP LINC01303 expression in LSCC tissues was notably higher than that in adjacent normal tissues. Mechanically, LINC01303 acted as carcinogenic lncRNA in LSCC by regulating miR-200c/TIMP2 axis. High LINC01303 expression was bound up with lymphatic metastasis and advanced clinical stage. Yes In addition, inhibition of LINC01303 by siRNA could evidently block LSCC cell proliferation, induce apoptosis, and inhibit invasion and migration. 33841686 LINC01303 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues & cells Interaction(miR-429/ZEB1/EMT Axis) In Vivo Experiment//Transfection//FISH//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay "LINC01303 expression was higher in OSCC tissues compared with adjacent nontumor tissues. LINC01303 was found to be localized in the cytoplasm of OSCC cells. Knockdown of LINC01303 inhibited OSCC cell proliferation and invasion, whereas increasing the expression of LINC01303 showed the opposite effects. Furthermore, LINC01303 served as a miR-429 ""sponge"" and positively regulated ZEB1 expression. Moreover, LINC01303 promoted OSCC through miR-429/ZEB1 axis both in vivo and in vitro." Yes Knockdown of LINC01303 inhibited OSCC cell proliferation and invasion, whereas increasing the expression of LINC01303 showed the opposite effects. 34912458 LINC01287 LncRNA Homo sapiens Breast Neoplasms BC cells and tissues Interaction(miR-98/IGF1R ) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay LINC01287 expression markedly increased in BC cell lines. Subsequent studies identified LINC01287 as a downstream target of miR-98.In addition, LINC01287 knockdown and miR-98 overexpression significantly stagnated progression of BC cells. LINC01287 knockdown also downregulated IGF1R levels. Moreover, LINC01287 knockdown notably downregulated the phosphorylation of MEK1/2 and ERK1/2. Our findings showed that LINC01287 was overexpressed in BC cells and tissues. Yes The in vivo assay verified that LINC01287 can regulate tumorigenesis of BC. 35695608 LINC01278 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-134-5p/KDM2A axis] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay LINC01278 was upregulated in CRC tissues and cell lines, and knockdown of LINC01278 suppressed CRC cell progression. Our study demonstrated that LINC01278 upregulated KDM2A to promote CRC progression by interacting with miR-143, suggesting that LINC01278 might be a new therapeutic target of CRC. Yes LINC01278 was upregulated in CRC tissues and cell lines, and knockdown of LINC01278 suppressed CRC cell progression. 33155208 LINC01278 LncRNA Homo sapiens Osteosarcoma tumor tissues regulation[miR-133a-3p/PTHR1 signaling] qRT-PCR Then, we found that the expression of LINC01278 tested by quantitative reverse-transcription polymerase chain reaction was enhanced in tumor tissues compared with the para-carcinoma tissues and related to clinical stage, distant metastasis in osteosarcoma. Our findings clarified that the carcinogenic effect of LINC01278 in osteosarcoma was mediated through miR-133a-3p/PTHR1 signaling, creating a novel insight into good targets for the therapy and prognosis of osteosarcoma. Then, we found that the expression of LINC01278 tested by quantitative reverse-transcription polymerase chain reaction was enhanced in tumor tissues compared with the para-carcinoma tissues and related to clinical stage, distant metastasis in osteosarcoma. Yes Moreover, LINC01278 promoted proliferation and restrained apoptosis in osteosarcoma cells. 31994731 LINC01278 LncRNA Homo sapiens Osteosarcoma OS tissues and serum Interaction(miR-134-5p/KRAS Axis) qRT-PCR//RNA Pull-Down qRT-PCR showed that LINC01278 increased in OS tissues and serum, indicating poor prognosis. In addition, LINC01278 was also of high value for OS diagnosis. Functional experiments showed that LINC01278 inhibited KRAS-mediated OS cell proliferation and metastasis through miR-134-5p. Finally, the results of an in vivo animal model indicated that LINC01278 promoted OS growth. qRT-PCR showed that LINC01278 increased in OS tissues and serum, indicating poor prognosis. Yes Functional experiments showed that LINC01278 inhibited KRAS-mediated OS cell proliferation and metastasis through miR-134-5p. Finally, the results of an in vivo animal model indicated that LINC01278 promoted OS growth. 33531816 LINC01270 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-326/EFNA3 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our findings indicated that LINC01270 expression was significantly up-regulated in GC tissues and cell lines. Functional experiments identified that lncRNA LINC01270 could positively regulate EFNA3 expression by serving as a competing endogenous RNA (ceRNA) for miR-326. Through rescue assays, inhibition of GC progression caused by LINC01270 suppression was found to be reversed by the application of miR-326 inhibitor or EFNA3 overexpression. Yes Additionally, LINC01270 knockdown attenuated GC progression through inhibiting cell proliferation, migration, and invasion. 35345980 LINC01270 LncRNA Homo sapiens Esophageal Neoplasms EC tissues and cells Regulation（GSTP1methylation） qRT-PCR//MTT LINC01270 was up-regulated and GSTP1 was down-regulated in EC tissues and cells. We found that LINC01270 recruited the DNA methyltransferases DNMT1, DNMT3A and DNMT3B initiating GSTP1 promoter methylation, thereby leading to the proliferation, migration, invasion and drug resistance of EC cells. Yes Silencing of LINC01270 inhibited migration and invasion, and enhanced the sensitivity of 5-FU in EC cells. 33199829 LINC01270 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Expression[highly expressed] qRT-PCR Among these, two lincRNAs (LINC01270 and LINC00449) were significantly associated with both worse overall survival and DFS and were expressed at significantly higher levels in tumor tissues compared with adjacent normal breast tissues (log2[Fold Change] > 0.5 and FDR < 0.05). Yes We further evaluated the potential functions of LINC01270 and LINC00449 using in vitro functional experiments and found that siRNA-mediated knockdown of LINC01270 and LINC00449 expression significantly decreased cell viability, colony formation and cell migration ability in TNBC cells (P < 0.05). 33247368 LINC01270 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tumor tissues and cell lines Interaction(miR-326/PI3K/AKT pathway) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay The overexpression of LINC01270 was then verified in LUAD tumor tissues and cell lines by qRT-PCR. Moreover, LINC01270 was found inhibiting miR-326 and thereby overexpressing the abundance of LARP1 to promote LUAD development via PI3K/AKT pathway. Yes LINC01270 knockdown resulted in impaired cell proliferative and invasive ability via CCK-8 assay, EdU assay, colony formation assay, transwell assay, while aberrant upregulation of LINC01270 led to enhanced cell growth and invasion.It was also proved that LINC01270 knockdown could suppress LUAD tumor growth in vivo. 36694453 LINC01320 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cells Interaction(miR495-5p/RAB19 axis) RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LINC01320 was highly expressed in gastric cancer tissues and cells. Moreover, miR-495-5p was predicted and demonstrated to target LINC01320 and RAB19. Yes LINC01320 overexpression promoted the proliferation, migration, and invasion of gastric cancer cells, while LINC01320 knockdown exerted the opposite effects. 34288797 LINC01354 LncRNA Homo sapiens Osteosarcoma OS tissues, serum and cells regulation[Integrin β1] qRT-PCR//Western Blot//Transwell Assay LINC01354 was overexpressed in OS tissues, serum and cells.LINC01354 promote OS cell EMT and invasion through up-regulating integrin β1. Yes LINC01354 overexpression promoted OS cells invasion, EMT and integrin β1 expression, while knockdown of LINC01354 inhibited OS cell invasion, epithelial-mesenchymal transition (EMT) and integrin β1 expression. 32111497 LINC01426 LncRNA Homo sapiens Glioma glioma cells Interaction(miR-661/Mdm2 axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//IHC//Bioinformatics Analysis LINC01426, which was high-expressed in glioma and was related to poor prognosis, could be used as a diagnostic marker for glioma. LINC01426 targeted and inversely correlated with miR-661, which was low-expressed in glioma. MiR-661 inhibitor evidently overturned the effect of siLINC01426 on biological functions, proliferation, and apoptosis-related proteins of glioma cells. Mdm2 bound to miR-661. Moreover, siMdm2 reversed the effects of miR-661 inhibitor on the biological characteristics and Mdm2/p53/p21 expression of glioma cells. LINC01426, which was high-expressed in glioma and was related to poor prognosis, could be used as a diagnostic marker for glioma. Yes SiLINC01426 inhibited the malignant phenotype of glioma cells in vitro and attenuated tumor growth and PCNA expression in vivo, while the effects of LINC01426 were the opposite. 35772605 LINC01354 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[Wnt/β-catenin signaling pathway] qRT-PCR//RNA Pull-Down//RIP//Western Blot The upregulation of LINC01354 in CRC and its prognostic significance were identified by TCGA database and confirmed in CRC tissues. Our investigations proposed novel regulatory axis of LINC01354/hnRNP-D/Wnt/β-catenin, which might be in favor of exploring novel therapeutic regimens for the clinical treatment of CRC. Yes Functionally, forced expression of LINC01354 promoted, while knockdown of LINC01354 inhibited cell proliferation, migration and EMT phenotype formation of CRC cells. 30987669 LINC01426 LncRNA Homo sapiens Glioblastoma GBM tissues and cell lines regulation[miR-345-3p,VAMP8] CCK8//qRT-PCR//Luciferase Report Assay//RIP LINC01426 is up-regulated in malignant GBM tissues and cell lines and it is capable to promote GBM cell proliferation and growth. Mechanistically, LINC01426 serves as a molecular sponge to sequester the miR345-3p and thus enhancing the level of VAMP8, an oncogenic coding gene, to promote GBM progression. Yes LINC01426 is up-regulated in malignant GBM tissues and cell lines and it is capable to promote GBM cell proliferation and growth. 32699526 LINC01426 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues interaction[hsa-miR-30b-3p] RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//FISH//MTT//Luciferase Report Assay//Transwell Assay We note that LINC01426 expression was markedly upregulated in LUAD tissues, and that functional assays verified that LINC01426 knockdown markedly inhibited cell proliferation, migration, and invasion in vitro. Our study also found that LINC01426 bound to hsa-miR-30b-3p as a competitive endogenous RNA in LUAD. Moreover, LINC01426 affected LUAD wound healing by interacting and combining with AZGP1, and LINC01426 expression was significantly associated with tumor-node-metastasis (TNM) staging and prognosis in patients with LUAD. Yes We note that LINC01426 expression was markedly upregulated in LUAD tissues, and that functional assays verified that LINC01426 knockdown markedly inhibited cell proliferation, migration, and invasion in vitro. Xenografts derived from A549 cells knocked down of LINC01426 had evidently lower tumor weights and smaller tumor volumes. 32953928 LINC01426 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Regulation(hedgehog pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Co-IP//Tunel//Flow Cytometry//qRT-PCR//FISH//RIP//Colony Formation Assay//EdU Staining//IF We applied bioinformatics analysis to find the expression of LINC01426 was upregulated in LUAD tissue. Functionally, silencing of LINC01426 obviously suppressed the proliferation, migration, epithelial-mesenchymal transition (EMT), and stemness of LUAD cells. Then, we observed that LINC01426 functioned through the hedgehog pathway in LUAD. The effect of LINC01426 knockdown could be fully reversed by adding hedgehog pathway activator SAG. In addition, we proved that LINC01426 could not affect SHH transcription and its mRNA level. Pull-down sliver staining and RIP assay revealed that LINC01426 could interact with USP22. Ubiquitination assays manifested that LINC01426 and USP22 modulated SHH ubiquitination levels. Rescue assays verified that SHH overexpression rescued the cell growth, migration, and stemness suppressed by LINC01426 silencing. In conclusion, LINC01426 promotes LUAD progression by recruiting USP22 to stabilize SHH protein and thus activate the hedgehog pathway. Yes Pull-down sliver staining and RIP assay revealed that LINC01426 could interact with USP22. Ubiquitination assays manifested that LINC01426 and USP22 modulated SHH ubiquitination levels. Rescue assays verified that SHH overexpression rescued the cell growth, migration, and stemness suppressed by LINC01426 silencing. 33568633 LINC01426 LncRNA Homo sapiens lung non-small cell carcinoma NSCLC tissues and cells Interaction(miR-143-3p/USP28) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//EdU Staining//Transwell Assay Our results confirmed that LINC01426 and USP28 expression were increased, while miR-143-3p expression was decreased in NSCLC tissues and cells. Additionally, LINC01426 regulated USP28 expression by sponging miR-143-3p. USP28 overexpression partly overturned the inhibitory effect of miR-143-3p on NSCLC progression. Yes Further functional experiments demonstrated that LINC01426 inhibition markedly impaired cell proliferation, migration, invasion, autophagy, and glycolysis while induced apoptosis in NSCLC cells, and LINC01426 derived malignant behaviors of NSCLC cells by sponging miR-143-3p. 35639219 LINC01419 LncRNA Homo sapiens Carcinoma, Hepatocellular regulation[ EZH2-regulated RECK] RNA-seq Interaction between LINC01419 and FUS stabilized EZH2 mRNA thereby enhancing EZH2 expression. Yes In vitro study revealed that LINC01419 promotes growth and migration of HCC cells. 32522890 LINC01419 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(ZIC1/PI3K/Akt signaling pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Transwell Assay According to the results, LINC01419 was highly expressed in HCC tissues and cells, while ZIC1 was poorly expressed.LINC01419 targeted and downregulated ZIC1 expression.Furthermore, LINC01419 increased the methylation of ZIC1 promoter and repressed ZIC1 expression. PI3K/Akt signaling pathway was activated by LINC01419 overexpression and ZIC1 knockdown, under which conditions, the HCC cell self-renewal and proliferation were promoted while cell apoptosis was attenuated, accompanied by accelerated formation and metastasis of xenografted tumors in mice. Yes PI3K/Akt signaling pathway was activated by LINC01419 overexpression and ZIC1 knockdown, under which conditions, the HCC cell self-renewal and proliferation were promoted while cell apoptosis was attenuated, accompanied by accelerated formation and metastasis of xenografted tumors in mice. 33772101 LINC01419 LncRNA Homo sapiens Osteosarcoma OS tissues and cells regulation[miR-519a-3p/PDRG1 axis ] RNA Pull-Down//Tunel//qRT-PCR//Transwell Assay//EdU Staining//IF LINC01419 expression was elevated in OS tissues and cells.LINC01419 mediates malignant phenotypes in OS by targeting miR-519a-3p/PDRG1 axis. Yes Functionally, LINC01419 accelerated OS cell proliferation, motility and EMT. In vivo assay showed that silencing LINC01419 hindered the growth of OS tumors. 32390762 LINC01410 LncRNA Homo sapiens Colonic Neoplasms CC tissues interaction[miR-3128] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In the present study, LINC01410 was identified to be highly expressed in CC tissues compared to adjacent normal tissues. In conclusion, the present study demonstrated that LINC01410 functions as an oncogene in CC, at least in part by directly inhibiting miR-3128. It was indicated that high expression of LINC01410 in CC tissues was associated with poor prognosis. Yes Further functional study suggested that LINC01410 knockdown significantly reduced the proliferation and invasive capacity of HT-29 and SW620 cells, and inhibited the cell cycle. 30546401 LINC01410 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-497-5p/HMGA2 axis) qRT-PCR//Luciferase Report Assay LINC01410 and HMGA2 were high, and miR-497-5p showed low expression in OS tissues and cells. We have demonstrated that LINC01410 promoted OS development partly by miR-497-5p/HMGA2 signal transduction pathway and this provides a reference for studying the mechanism of LINC01410 in OS. Yes Cell function assay demonstrated that LINC01410 or HMGA2 knockdown or miR-497-5p overexpression obviously restrained OS proliferation, invasion, and migration. Oppositely, inhibiting miR-497-5p had the opposite effects. 34605103 LINC01410 LncRNA Homo sapiens Osteosarcoma OS tissues Interaction(miR-122-5p/NDRG3 axis) CCK8//qRT-PCR LINC01410 was overexpressed in OS tissues. Our studies also showed that LINC01410 binds to miR-122-5p, and miR-122-5p binds to NDRG3. Yes Furthermore, it was confirmed that LINC01410 facilitated OS cell proliferation and migration. 33583123 LINC01410 LncRNA Homo sapiens Glioma glioma cells Interaction( miR-506-3p/NOTCH2 ) RNA Pull-Down//Western Blot//Bioinformatics Analysis//Transfection//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//ChIP Our data supported that LINC01410 was up-regulated in glioma cells. Bioinformatics predictions and the integrated experiments identified that MYC activated LINC01410 transcription and LINC01410 promoted the levels of NOTCH2 through sponging miR-506-3p and further motivated Notch signaling pathway. Yes Rescue assays validated that LINC01410 exerted its influential functions on glioma cell proliferation and apoptosis via enhancing NOTCH2 expression. 33712887 LINC01410 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues Interaction[regulating the miR-497-5p and IFITM3 gene expression] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The expression of LINC01410 in the pancreatic cancer tissues was significantly higher than that in the adjacent tissues [(3.46±0.32) vs (0.65±0.08), P<0.01]. Down-regulation of LINC01410 expression inhibits the proliferation and migration of pancreatic cancer BxPC-3 cells, and its mechanism may be closely related to regulating the miR-497-5p and IFITM3 gene expression. Yes After knock-down of the LINC01410 expression in the pancreatic cancer cell line BxPC-3, the cell proliferation was significantly inhibited (P<0.05), and the cell migration ability was decreased (P<0.05). 31137129 LINC01410 LncRNA Homo sapiens Gallbladder Neoplasms GBC tissues Interaction(STAT5 ) In Vivo Experiment//RNA Pull-Down//Western Blot//ISH//Transfection//Wound Healing Assay//qRT-PCR//RIP//migration assay//Cell Proliferation Assay LINC01410 was significantly upregulated in the GBC tissues compared to adjacent non-tumor tissues. From RNA pull-down and RIP assay, we identified that STAT5 was a critical downstream target of LINC01410. High LINC01410 expression was significantly associated with poor prognosis of GBC patients. Yes Overexpression of LINC01410 promoted GBC cell proliferation, migration, and invasion in vitro and GBC progression in vivo, whereas LINC01410 downregulation rescued these effects in vitro. 34322379 LINC01410 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and CCA cell regulation[miR-124-3p/SMAD5 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The high expression of LINC01410 was proved in CCA tissues and CCA cell lines. LINC01410 facilitates cell proliferation, migration and invasion through miR-124-3p/SMAD5 axis. Also, CCA patients with high LINC01410 level presented poor prognosis. Yes LINC01410 deficiency impeded cell proliferation, migration and invasion in HuCCT1 and RBE cell lines. 31951299 LINC01410 LncRNA Homo sapiens Neuroblastoma NB tissues and cells Regulation(miR-545-3p/HK2 Axis) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay LINC01410 and HK2 were highly expressed while miR-545-3p was lowly expressed in NB tissues and cells. LINC01410 knockdown inhibited tumorigenesis by repressing cell proliferation and invasion, and increased the radiosensitivity via inhibiting colony formation rates and glycolysis. LINC01410 knockdown also suppressed tumor growth in vivo. Moreover, miR-545-3p could bind to LINC01410 and its downregulation reversed the effects of LINC01410 knockdown on tumorigenesis and radiosensitivity. Additionally, HK2 was a direct target of miR-545-3p and its overexpression attenuated the effects of miR-545-3p restoration on suppression of tumorigenesis and promotion of radiosensitivity. Besides, LINC01410 functioned as a molecular sponge of miR-545-3p to regulate HK2 expression. Yes LINC01410 knockdown inhibited tumorigenesis by repressing cell proliferation and invasion, and increased the radiosensitivity via inhibiting colony formation rates and glycolysis. LINC01410 knockdown also suppressed tumor growth in vivo. 34040388 LINC01391 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-12116/CMTM2 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Here, we report that LINC01391 was low expressed in GC tissues and cell lines. LINC01391 restrained aerobic glycolysis and tumorigenesis of GC via targeting miR-12116/CMTM2 axis, which provides new insights into mechanism of GC progression. Yes LINC01391 overexpression hampered GC cell proliferation, migration, invasion and aerobic glycolysis, while LINC01391 knockdown demonstrated the opposite effects. 33033510 LINC01385 LncRNA Homo sapiens Osteoarthritis OA tissues and IL-1β-induced HC-a Interaction(microRNA-140-3p/TLR4 axis) qRT-PCR//MTT//Co-IP//Western Blot LINC01385 mRNA expression level was increased in OA tissues and IL-1β-induced HC-a.In addition, it was confirmed that LINC01385 targeted miR-140-3p, while TLR4 was a target gene of miR-140-3p. Negative correlations between LINC01385 and miR-140-3p, and between miR-140-3p and TLR4 were observed in OA tissues. Yes LINC01385 knockdown and miR-140-3p mimics reduced the concentration of inflammatory factors in IL-1β-induced HC-a and promoted cell survival. 34539840 LINC01385 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissue regulation[miR-140-3p/Twist1 signaling pathway] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining Our data showed that LINC01385 expression was significantly increased NPC and correlated with advanced clinical features and poor prognosis.Thus, we illustrated that LINC01385 aggravated the progression of NPC by sponging miR-140-3p and upregulating Twist1 expression, which implied LINC01385 might serve as a new potential therapeutic target for NPC treatment. Our data showed that LINC01385 expression was significantly increased NPC and correlated with advanced clinical features and poor prognosis. Yes Function assays showed that knockdown of LINC01385 expression reduced the proliferation and invasion abilities of NPC cells in vitro. 32264733 LINC01355 LncRNA Homo sapiens Breast Neoplasms cell lines Interaction[repression of CCND1] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Colony Formation Assay//ChIP LINC01355 were downregulated in breast cancer cells relative to non-malignant breast epithelial cells.LINC01355 acts as a tumor suppressor in breast cancer, which is ascribed to enhancement of FOXO3-mediated transcriptional repression of CCND1. Yes Overexpression of LINC01355 significantly inhibited proliferation, colony formation, and tumorigenesis of breast cancer cells. 31243265 LINC01608 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell line Regulation(EGFR/ERK axis) ISH//qRT-PCR//RIP//Luciferase Report Assay//IHC LINC01608 was overexpressed in HCC tissues, and high LINC01608 expression predicted poor overall survival (OS) and disease-free survival (DFS) in HCC patients. Furthermore, we demonstrated that LINC01608 could sponge to miR-875-5p and activate the EGFR/ERK pathway. Moreover, we identified transcriptional factor YY1 could bind to the promoter of LINC01608 and induce its transcription. LINC01608 was overexpressed in HCC tissues, and high LINC01608 expression predicted poor overall survival (OS) and disease-free survival (DFS) in HCC patients. Yes LINC01608 could promote HCC cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in vitro and in vivo. 36385489 LINC01612 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-494/ATF3/p53 axis) qRT-PCR In this study, we discovered that Linc01612 is significantly down-regulated in HCC tissues than in non-tumor tissues and correlated with poor prognosis. Mechanistically, in p53-expressing hepatoma cells, Linc01612 acts as a competitive endogenous RNA and promotes the expression of activation transcription factor 3 (ATF3) by sponging microRNA-494 (miR-494), which in turn inhibits MDM2-mediated ubiquitination of p53 and activates the p53 pathway. Furthermore, in p53-null hepatoma cells, Linc01612 exerts its biological functions by physically interacting with Y-box binding protein 1 protein (YBX1) and promoting the ubiquitin-mediated degradation of YBX1. Interestingly, the Linc01612-YBX1 signaling pathway is also present in p53-expressing hepatoma cells. In this study, we discovered that Linc01612 is significantly down-regulated in HCC tissues than in non-tumor tissues and correlated with poor prognosis. Yes Linc01612 mainly localizes in the cytoplasm and functions as a tumor suppressor by repressing the growth and metastasis of hepatoma cells in vitro and in vivo. 35541917 LINC01614 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cells Interaction(ANXA2 and p65 /NF-κB) qRT-PCR//RNA-seq//Western Blot//Microarray A CAF-specific long noncoding RNA, LINC01614, packaged by CAF-derived exosomes, mediates the enhancement of glutamine uptake in LUAD cells. Mechanistically, LINC01614 directly interacts with ANXA2 and p65 to facilitate the activation of NF-κB, which leads to the upregulation of the glutamine transporters SLC38A2 and SLC7A5 and eventually enhances the glutamine influx of cancer cells. Clinically, LINC01614 expression in CAFs is associated with the glutamine influx and poor prognosis of patients with LUAD. Yes Reciprocally, tumor-derived proinflammatory cytokines upregulate LINC01614 in CAFs, constituting a feedforward loop between CAFs and cancer cells. Blocking exosome-transmitted LINC01614 inhibits glutamine addiction and LUAD growth in vivo. 36209111 LINC02446 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction(EIF3G/mTOR ) qRT-PCR//RNA Pull-Down//RIP In the present study, we used the TCGA and GEO databases and identified LINC02446 as associated with prognosis and differentially expressed in bladder cancer tissues and para-cancer tissues. Additionally, we found that LINC02446 could bind to the EIF3G protein and regulate the protein stability of EIF3G and then inhibit the mTOR signalling pathway. Yes Then, we found that LINC02446 could affect the proliferation, migration and invasion of BC cells. 33526846 LINC02418 LncRNA Homo sapiens Colonic Neoplasms CRC tissues regulation[miR-34b-5p/BCL2 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LINC02418 was upregulated in human colon cancer samples when compared with adjacent tissue, and its high expressional level correlated with poor prognosis of CRC patients. LINC02418 acted as a tumor driver by negatively regulating cell apoptosis through LINC02418/miR-34b-5p/BCL2 axis in CRC. LINC02418 was upregulated in human colon cancer samples when compared with adjacent tissue, and its high expressional level correlated with poor prognosis of CRC patients. Yes LINC02418 promoted cancer progression by enhancing tumor growth, cell mobility and invasiveness of colon cancer cells.LINC02418 reduced cell proliferation, while transfection of miR-34b-5p inhibitor or BCL2 into LINC02418-silenced CRC cells significantly promoted CRC cells growth. 32973404 LINC02418 LncRNA Homo sapiens Adenocarcinoma of Lung LAD specimens and cells regulation[miR-4677-3p/KNL1 signaling] RNA Pull-Down//Western Blot//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay High expression of LINC02418 was observed in LAD specimens and cells.LINC02418 contributes to the malignancy in LAD via miR-4677-3p/KNL1 signaling, providing a probable therapeutic direction for LAD. Yes Downregulation of LINC02418 obstructed the proliferation and motility of LAD cells. 32795273 LINC02381 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues regulation[Wnt Signaling Pathway] qRT-PCR//Luciferase Report Assay//Microarray Looking for the potential molecular regulators of gastric cancer incidence and progression, LINC02381 was identified as a downregulated lncRNA in gastric cancer tissues by analysis of available microarray and RNA-seq data and RT-qPCR confirmed this differential expression.Furthermore, we found that increased expression of LINC02381 attenuates Wnt pathway activity. Yes Also, functional analysis indicates that LINC02381 arrests cell cycle, increases apoptosis and caspase activity, and reduces cell survival and proliferation rate of the human gastric cancer cell lines AGS and MKN45. 33194632 LINC02381 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[PI3K-Akt signaling pathway] qRT-PCR Consistently, RT-qPCR results showed that LINC02381 was down regulated in CRC tissues and also in different cancerous cell lines. Altogether, the result of this study suggests that LINC02381 might have suppressive effects on human colorectal cancer tumorigenesis partly by regulating PI3K signaling pathway. Yes Then, the functional changes of the cells in response to LINC02381 alteration were assessed and the data indicated that LINC02381 up-regulation suppressed cell viability and proliferation while increasing the apoptosis in CRC-originated cell lines. 32092325 LINC02381 LncRNA Homo sapiens Osteosarcoma osteosarcoma specimens and cells Interaction(miR-503-5p/CDCA4 axis) qRT-PCR//RIP//ChIP We observed that the expression of LINC02381 and cell division cycle-associated protein 4 (CDCA4) were distinctly increased in osteosarcoma specimens and cells, while miR-503-5p expression was decreased. Additionally, ETS transcription factor ELK1 (ELK1) could bind directly to the LINC02381 promoter region and activate its transcription. What's more, LINC02381 could down-regulate CDCA4 via sponging miR-503-5p, and there existed a negative correlation between LINC02381 expression and miR-503-5p expression in 92 osteosarcoma samples. Rescue experiments proved the carcinogenic role of LINC02381/miR-503-5p/CDCA4 axis in osteosarcoma progression. Clinical assays revealed that high LINC02381 was associated with advanced clinical progress and poor clinical outcome. Yes Functionally, knockdown of LINC02381 suppressed the proliferation, migration and invasion of osteosarcoma cells. 33640603 LINC02381 LncRNA Homo sapiens Glioma glioma cells Interaction(CEBPβ/CBX5 ) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//ChIP By RT-qPCR, we confirmed LINC02381 upregulation in glioma cells. To conclude, LINC02381 could facilitate CBX5 transcription via interaction with CEBPβ, thus exerting its oncogenic role in glioma cells, which could contribute to better understanding of glioma. Yes Functional experiments demonstrated that LINC02381 knockdown repressed glioma cell proliferation and induced apoptosis. 34274429 LINC02362 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miR-516b-5p/ SOSC2 axis) qRT-PCR//Western Blot Here, we found that a long non-coding RNA (lncRNA) named LINC02362, whose biological effects have yet been unveiled in cancers, was associated with a better prognosis in patients with HCC. Moreover, miR-516b-5p was enriched as a target of LINC02362, which functioned as a sponge to regulate the endogenous levels of miR-516b-5p. Furthermore, we confirmed that SOSC2 served as a downstream target gene which was negatively controlled by miR-516b-5p. Importantly, a series of rescue experiments indicated that the tumor-suppressive effects of LINC02362 were achieved through the modulation of the miR-516b-5p/SOSC2 axis. Here, we found that a long non-coding RNA (lncRNA) named LINC02362, whose biological effects have yet been unveiled in cancers, was associated with a better prognosis in patients with HCC. Yes Gain-of-function analyses showed that LINC02362 inhibited the survival, migration, invasion and epithelial-to-mesenchymal transition (EMT) of HCC cells. 34990401 LINC02323 LncRNA Homo sapiens Ovarian Neoplasms blood regulation[TGF-β receptor 1,miR-1343-3p] qRT-PCR//MTT//Western Blot//Microarray In patients with ovarian cancer, lncRNA LINC02323 expression was up-regulated and miR-1343-3p expression was down-regulated. Our findings show that Novel long noncoding RNA LINC02323 promotes cell growth of ovarian cancer via TGF-β receptor 1 by miR-1343-3p. Yes Over-expression of lncRNA LINC02323 promoted cell growth and reduced LDH activity levels in vitro model by suppression of miR-1343-3p expression. 33247856 LINC02321 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissue Regulation(VEGFA ) CCK8//qRT-PCR The Cancer Genome Atlas prediction and RT?qPCR experimental results demonstrated that only LINC02321 was highly expressed in bladder cancer tissue and promoted the proliferation, invasion, migration and cisplatin resistance of the malignancy. Yes The Cancer Genome Atlas prediction and RT?qPCR experimental results demonstrated that only LINC02321 was highly expressed in bladder cancer tissue and promoted the proliferation, invasion, migration and cisplatin resistance of the malignancy. 36579659 LINC02273 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[LINC02273-hnRNPL-AGR2 axis ] RNA Pull-Down//ChIP//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Microarray//Transwell Assay We identified a novel long noncoding RNA LINC02273, whose expression was significantly elevated in metastatic lesions compared to the primary tumors, by genetic screen of matched tumor samples.Mechanistically, hnRNPL-LINC02273 formed a complex which activated AGR2 transcription and promoted cancer metastasis. The recruitment of hnRNPL-LINC02273 complex to AGR2 promoter region epigenetically upregulated AGR2 by augmenting local H3K4me3 and H3K27ac levels. Yes Increased LINC02273 promoted breast cancer metastasis in vitro and in vivo. 31856843 LINC02273 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Regulation( β-catenin) qRT-PCR Here, we showed the expression pattern and biological function of a recently identified lncRNA, LINC02273, in HCC. LINC02273 played a critical role in HCC progression via stabilizing β-catenin. Yes Knockdown of LINC02237 remarkably inhibited the proliferation, stemness, migration, and invasion abilities, whereas it increased the apoptosis of HCC cells. 35132378 LINC02257 LncRNA Homo sapiens Colorectal Neoplasms CRC specimens and cell lines Expression(highly expressed) CCK8//qRT-PCR We found that the expression of LINC02257 exhibited variable patterns of upregulation or downregulation in the various forms of cancer. In CRC, LINC02257 expression was distinctly increased in CRC specimens compared with normal specimens. The results of ROC curves revealed that the AUC was 0.886 (0.862 to 0.909, 95% CI, p < 0.001) in a comparison between CRC specimens and matched normal specimens. Survival studies revealed that high LINC02257 expression was associated with shorter overall survival and disease specific survival. More importantly, multivariate assays confirmed that high expression of LINC02257 was an independent prognostic factor for CRC patients. The results of RT-PCR indicated that LINC02257 expression was distinctly overexpressed in both CRC specimens and cell lines. In CRC, LINC02257 expression was distinctly increased in CRC specimens compared with normal specimens. The results of ROC curves revealed that the AUC was 0.886 (0.862 to 0.909, 95% CI, p < 0.001) in a comparison between CRC specimens and matched normal specimens. Survival studies revealed that high LINC02257 expression was associated with shorter overall survival and disease specific survival. Yes The results of RT-PCR indicated that LINC02257 expression was distinctly overexpressed in both CRC specimens and cell lines. 36124032 LINC02253 LncRNA Homo sapiens Stomach Neoplasms GC cell Regulation(KRT18/MAPK/ERK pathwa) Western Blot//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay Here, we identified a novel oncogene, lncRNA LINC02253, in GC. LINC02253 expression was found to be significantly increased in GC. And LINC02253 expression was closely correlated with tumor size, lymph node metastasis and TNM stage of GC. Besides, GC patients with higher LINC02253 expression had worse 5-year overall survival. Additionally, LINC02253 promoted GC cell growth, migration and invasion both in vitro and in vivo. Mechanistically, we determined that LINC02253 increased KRT18 expression through enhancing the stability of KRT18 mRNA. Furthermore, LINC02253 increased m6A modification of KRT18 mRNA to stabilize KRT18 mRNA by recruiting m6A writer METTL3. And, rescue experiments revealed that KRT18 mediated the effects of LINC02253 on growth, migration and invasion of GC cells through activating MAPK/ERK signaling pathway. In conclusion, we demonstrates that oncogenic lncRNA LINC02253 positively regulates GC growth and metastasis via increasing METTL3-mediated mRNA stability of KRT18, extending the understanding of GC pathogenesis regulated by lncRNAs. LINC02253 expression was found to be significantly increased in GC. And LINC02253 expression was closely correlated with tumor size, lymph node metastasis and TNM stage of GC. Besides, GC patients with higher LINC02253 expression had worse 5-year overall survival. Yes Mechanistically, we determined that LINC02253 increased KRT18 expression through enhancing the stability of KRT18 mRNA. And, rescue experiments revealed that KRT18 mediated the effects of LINC02253 on growth, migration and invasion of GC cells through activating MAPK/ERK signaling pathway. 35136989 LINC02200 LncRNA Homo sapiens Sinonasal Squamous Cell Carcinoma SNSCC tissue Interaction(NF-κB) ChIP//Western Blot//Wound Healing Assay//CCK8//RIP//Transwell Assay The expression of RP11-159K7.2 in SNSCC tissue was significantly higher than that in adjacent tissues. RP11-159K7.2 directly bound to nuclear factor-κB (NF-κB) in SNSCC cells, and the regulation of RP11-159K7.2 on the proliferation and invasion of SNSCC cells depended on NF-κB. After the down-regulation of RP11-159K7.2, the proliferation, migration and invasion ability of SNSCC cells decreased significantly, and the growth of SNSCC xenograft was significantly inhibited. Yes RP11-159K7.2 expression was closely related with T grade, nodal metastasis and differentiation of SNSCC (χ2 value was 4.697, 4.235 and 10.753, respectively, all P<0.05). The five-year survival rate of RP11-159K7.2 high expression patients was significantly lower than that of RP11-159K7.2 low expression ones (P=0.013 7). 34256488 LINC02154 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Regulation(SPC24/PI3K/AKT ) qRT-PCR We identified a new lncRNA, Linc02154, that is highly expressed in HCC cells and tissues of patients with a poor overall survival. Using a dual luciferase reporter assay we found that Linc02154 can enhance SPC24 promoter (-500 bp ~ -1000 region) activity. Exogenous over-expression of Linc02154 led to up-regulation of SPC24 by activating PI3K/AKT and its downstream signals, including cell cycle progression and EMT-associated gene expression. We identified a new lncRNA, Linc02154, that is highly expressed in HCC cells and tissues of patients with a poor overall survival. Yes Functional experiments revealed that exogenous Linc02154 expression in MHCC-97H and SK-Hep1 cells promoted their proliferation, migration and invasion in vitro and their tumorigenesis in vivo. 35543858 LINC02145 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miRNA-140/MMP9 axis] qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Transwell Assay FLJ33360 was upregulated in HCC tissues relative to paracancerous ones. It accelerates the metastasis of HCC through targeting miRNA-140/MMP9 axis. Yes After knockdown of FLJ33360, migratory and invasive capacities in Bel-7402 and HepG2 cells were attenuated. 32194906 LINC02042 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cell lines, tissues and plasma regulation[c-Myc,YBX1 ] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay//ChIP Linc02042 was found to be markedly upregulated in ESCC cell lines, tissues and plasma, and was closely correlated with malignant clinical features. Mechanistically, linc02042 acted as a scaffold for YBX-1 binding to the 3'-UTR of c-Myc mRNA, leading to enhanced c-Myc mRNA stability, thereby facilitating ESCC growth and metastasis. Yes Knockdown of linc02042 significantly inhibited ESCC cell viability and invasion in vitro as well as tumor growth and lung metastasis in vivo, whereas overexpression of linc02042 resulted in the opposite results. 32161513 LINC02041 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells regulation[Notch pathway] qRT-PCR//Western Blot RP11-567G11.1 expression was significantly up-regulated in RCC tissues and cells. RP11-567G11.1 accelerates the proliferative and invasive abilities of RCC through activating the Notch pathway. Meanwhile, RP11-567G11.1 was highly expressed in RCC patients with advanced stage. Yes Knockdown of RP11-567G11.1 significantly attenuated proliferative and invasive abilities of 786-O and 769-P cells. 32432737 LINC02418 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[miR-4677-3p/SEC61G] CCK8//qRT-PCR//Transwell Assay LINC02418 was found as upregulated expression in both NSCLC tissues and cells. Mechanistically, we showed LINC02418 could interact with microRNA-4677-3p (miR-4677-3p) to regulate Sec61 gamma subunit (SEC61G) expression. Yes Functional assays showed that LINC02418 knockdown suppressed NSCLC cell proliferation and invasion but promoted cell apoptosis, while the overexpression of LINC02418 exerts opposite effects. 31841189 LINC02465 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[PI3K/AKT pathway ] IHC//Western Blot//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay As shown in Fig. 1B, LINC02465 exhibits markedly high expression in tumor tissues compared with adjacent nontumor tissues. We also discovered that LINC02465 level is remarkably increased in four GC cell lines (SGC7901, MGC-803, AGS, and BGC-823) in comparison with normal gastric cell line GES-1 (Fig. 1E). Taken together, LINC02465 is an oncogenic lncRNA that facilitates the tumorigenesis and progression of GC via PI3K/AKT pathway, demonstrating a novel effective therapeutic target and prognostic biomarker for GC patients. Here we discover LINC02465, a novel recognized lncRNA, is upregulated and correlated with tumor size, tumor stage, lymph node metastasis, and differentiation in gastric cancer. In addition, we found that high LINC02465 level in GC patients is closely related to poor prognosis. Yes Moreover, our findings reveal that LINC02465 silence suppresses cell proliferation and migration, invasion, and epithelial-mesenchymal transition in vitro. Conversely, LINC02465 overexpression displays a completely opposite way. 30632400 LINC01614 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines Interaction( GSK‑3β and AXIN1/ WNT/β‑catenin signaling pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Flow Cytometry//Colony Formation Assay//EdU Staining//Transwell Assay linc01614 was notably upregulated in PC tissues and cell lines and was associated with the poor disease-free survival of patients with PC according to the analysis of The Cancer Genome Atlas?derived datasets. Mechanistically, linc01614 overexpression stabilized the level of β‑catenin protein to hyperactivate the WNT/β‑catenin signaling pathway in PC cells. Further analyses revealed that linc01614 bound to GSK‑3β and perturbed the interaction between GSK‑3β and AXIN1, thereby preventing the formation of the β‑catenin degradation complex and reducing the degradation of β‑catenin. linc01614 was notably upregulated in PC tissues and cell lines and was associated with the poor disease-free survival of patients with PC according to the analysis of The Cancer Genome Atlas?derived datasets. Yes Functionally, linc01614 knockdown suppressed PC cell proliferation, migration and invasion in vitro, and inhibited tumor proliferation in vitro and in vivo. 35929518 LINC02470 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cells Interaction( LINC02470-miR-143-3p-SMAD3 ceRNA axis) qRT-PCR//Western Blot After screening the intersection of bioinformatic pipelines, LINC02470 was identified as the most upregulated lncRNA during bladder cancer initiation and progression. On a molecular level, miR-143-3p directly targets and reduces both LINC02470 and SMAD3 RNA expression. Therefore, the LINC02470-miR-143-3p-SMAD3 ceRNA axis rescues SMAD3 translation upon LINC02470 sponging miR-143-3p, and SMAD3 consequently activates the TGF-β-induced EMT process. Yes Both in vitro and in vivo biological effects indicated that LINC02470 promotes bladder cancer cell viability, migration, invasion, and tumorigenicity. 35205713 LINC02908 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR-661/HDAC11 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found C9orf139 was highly expressed in ESCC and knock down the expression of C9orf139 significantly suppressed cell proliferation, promoted apoptosis, and inhibited migration and invasion. C9orf139 was able to negatively regulate miR-661 expression. At the same time, HDAC11 expression was negatively regulated by miR-661. The C9orf139/miR-661/HDAC11 axis was further involved in regulating the expression of the NF-κB signaling pathway. Yes We found C9orf139 was highly expressed in ESCC and knock down the expression of C9orf139 significantly suppressed cell proliferation, promoted apoptosis, and inhibited migration and invasion. 35917643 LINC02893 LncRNA Homo sapiens Osteosarcoma cell lines regulation[TP53INP1] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IP//Colony Formation Assay The current study showed that long non-coding RNA NR_027471 was downregulated in osteosarcoma cells.These results suggested that overexpression of NR_027471 upregulated TP53INP1 by sponging to miR-8055, leading to suppression of osteosarcoma cell proliferation and progression. Yes In vitro and in vivo studies indicated that upregulation of NR_027471 impeded the viability, proliferation, and invasion of osteosarcoma, as well as induced cell cycle arrest at G1. 33117693 LINC02883 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[highly expressed] qRT-PCR We confirmed that KMU15 was expressed higher in bladder cancer tissues than paired control tissues. Moreover, the expression of KMU15 was significantly positively correlated with the grade, stage, metastasis, and recurrence of bladder cancer and was significantly negatively correlated with the prognosis. Yes In addition, KMU15 knockdown could significantly inhibit bladder cell proliferation, adhesion, migration, and chemoresistance and promoted apoptosis. Knockdown of KMU15 inhibited the growth of xenografts in nude mice and significantly prolonged the survival of tumor-bearing mice under cisplatin. 31850704 LINC02882 LncRNA Homo sapiens Stomach Neoplasms GC tissue and cell lines regulation[miR-339-HNRNPA1 interaction network] Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay Here we identified a novel lncRNA RP11-81H3.2 that was highly expressed in the GC tissue and cell lines.Mechanistically, we demonstrated that RP11-81H3.2 directly interacted with miR-339 while miR-339 regulated the HNRNPA1 expression by targeting HRRNPA1 3'-UTR. RP11-81H3.2-miR-339-HNRNPA1 interaction network regulated the GC cell proliferation, migration, and invasion. Yes RP11-81H3.2 knockdown significantly inhibited the proliferation, migration, and invasion of GC cells. Moreover, our results confirmed that RP11-81H3.2 knockdown suppressed the tumor growth of GC in a xenograft model in vivo. 32052594 LINC02875 LncRNA Homo sapiens Glioma glioma cells Epigenetics [methylation ] Transfection//Migration Assay//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay Furthermore, we identified two lncRNAs termed PCBP1-AS1 and LINC02875 that may be involved in the malignant progression of glioma cells by using the TCGA database. Yes Loss-of-function assays confirmed that knockdown of PCBP1-AS1 and LINC02876 inhibited the proliferation, migration, and invasion of glioma cells. 33828990 LINC02870 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC samples and cells Interaction(EIF4G1) qRT-PCR Upregulated expressions of LINC02870 were also found in our HCC samples compared to the para-tumor samples. Intriguingly, the most promising binding protein of LINC02870 was predicted and confirmed to be eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), an important component of the eukaryotic translation initiation factor 4F complex that initiates cap-dependent translation. Further investigation showed that LINC02870 increased the translation of SNAIL to induce malignant phenotypes in HCC cells. Additionally, HCC patients with higher expression levels of LINC02870 and EIF4G1 had shorter survival times than those with lower expression levels. Yes Moreover, overexpression of LINC02870 promoted the growth, migration, and invasion of HCC cells. 36583796 LINC02835 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[Binding p120-Catenin] RNA Pull-Down//Northern Blot//Western Blot//Wound Healing Assay//Luciferase Report Assay//Transwell Assay Mechanistically, lncMER52A stabilized p120-catenin and triggered the activation of Rho GTPase downstream of p120-catenin. Furthermore, we found that chromatin accessibility was crucial for the expression of lncMER52A. In addition, YY1 transcription factor bound to the cryptic MER52A LTR promoter and drove lncMER52A transcription in HCC. In conclusion, we identified an LTR-activated lncMER52A, which promoted the progression of HCC cells via stabilizing p120-catenin and activating p120-ctn/Rac1/Cdc42 axis. LncMER52A could serve as biomarker and therapeutic target for patients with HCC. SIGNIFICANCE: A novel long noncoding RNA lncMER52 modulates cell migration and invasion via posttranslational control of p120-catenin protein stability. HCC patients with higher lncMER52A had advanced TNM stage, less differentiated tumors, and shorter overall survival. Yes LncMER52A promoted invasion and metastasis of HCC cells in vitro and in vivo. 31874857 LINC02747 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues regulation[ LINC02747/miR-608/TFE3 pathway] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay We found that lncRNA LINC02747 was highly expressed in ccRCC (P < 0.001) and was closely related to high TNM stage (P = 0.006) and histological grade (P = 0.004) and poor prognosis of patients (P < 0.001). The LINC02747/miR-608/TFE3 pathway may become a new therapeutic target for ccRCC. We found that lncRNA LINC02747 was highly expressed in ccRCC (P < 0.001) and was closely related to high TNM stage (P = 0.006) and histological grade (P = 0.004) and poor prognosis of patients (P < 0.001). Yes In vivo and in vitro experiments confirmed that LINC02747 could promote the proliferation of ccRCC cells. 33425728 LINC02605 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-29c) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The result of dual-luciferase reporter assay represented a direct interaction of RP11-79H23.3 with miR-29c, which suppressed miR-29c expression that showed inversely correlation in NSCLC. Moreover, RP11-79H23.3 siRNA facilitated the progression of NSCLC partially via regulating the expression of miR-29c and the activation of Wnt/β-catenin signaling pathway. Yes RP11-79H23.3 downregulation facilitated cell proliferation, migration, and invasion of NSCLC. 35972581 LINC02605 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cells interaction[PTEN,hsa-miR-107 ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining We found that lncRNA RP11-79H23.3 and phosphatase and tensin homolog (PTEN) were significantly downregulated in BC tissues and cells.Mechanistically, we identified that RP11-79H23.3 could directly bind to miR-107 and abolish the suppressive effect on target gene PTEN, which leads to inactivation of the PI3K/Akt signaling pathway. Meanwhile, RP11-79H23.3 expression was negatively correlated with clinical stage in BC. Yes Functionally, we found that overexpression of RP11-79H23.3 could suppress cell proliferation, migration, and cell cycle progression, rearrange the cytoskeleton, and induce apoptosis in vitro. Moreover, upregulation of RP11-79H23.3 inhibited the angiogenesis, tumorigenesis, and lung metastasis in vivo, whereas RP11-79H23.3 knockdown exerted a contrary role. 30149689 LINC02587 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells lines Interaction(miR-143-3p/VDAC1 pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//Invasion Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis In the paper, we reported that MEOX2-AS1 levels were distinctly upregulated in CC cells and tissues, and higher MEOX2-AS1 expressions indicated a poor clinical outcome. Besides, STAT1 could activate transcriptions of MEOX2-AS1 by binding directly to its promoter region. The silence of MEOX2-AS1 suppressed the metastatic and proliferative ability of CC cells, as revealed by functional assays. Mechanistically, MEOX2-AS1 sponged miR-143-3p to regulate VDAC1 expressions. Furthermore, miR-143-3p inhibitor reversed the anti-proliferation and anti-metastasis effect of MEOX2-AS1 knockdown. Yes Loss-of-function experiments were performed for the assays of proliferation, migration, and invasion of CC cells after various treatments. 34224325 LINC02580 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues interaction[targeting SRSF1] RNA Pull-Down//ChIP//Western Blot//qRT-PCR//FISH//RIP//Transwell Assay LINC02580 was highly downregulated in HCC cohorts and was identified as a tumor suppressor. With respect to the underlying mechanism, we found that LINC02580 modulates the epithelial-mesenchymal transition (EMT) associated pathway in HCC cells by specifically binding to serine and arginine-rich splicing factor 1 (SRSF1). Low LINC02580 expression in patients with HCC was correlated with poor prognosis. Yes Functional assays indicated that LINC02580-deficient cells show enhanced colony formation, migration, and invasion in vitro and promote subcutaneous tumor formation and distant lung metastasis in vivo. 33168192 LINC02544 LncRNA Homo sapiens lung squamous cell carcinoma LUSC tissues and cell line Interaction(miR-138-5p) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Linc02544 was overexpressed in LUSC tissues from positive lymph node metastasis-positive and TNM high-stage patients.Expression of MMP-2, MMP-9, and vimentin was decreased while E-cadherin was increased in si-linc02544 cells compared with that in untreated cells. Mechanistically, we identified that linc02544 acted as a sponge of miR-138-5p, which expression had a negative correlation. E2F3 was a potential target of miR-138-5p. Linc02544 was overexpressed in LUSC tissues from positive lymph node metastasis-positive and TNM high-stage patients.Low linc02544 expression was associated with a longer survival rate. Yes Downregulation of linc02544 by si-linc02544 restrained cell growth capacities, migration, and invasion abilities. 35635595 LINC02535 LncRNA Homo sapiens Stomach Neoplasms PDGC tissues Expression [highly expressed] Bioinformatics Analysis//Wound Healing Assay//Migration Assay//CCK8//RNA-seq//Cell Apoptosis Assay//Invasion Assay LINC02535 expression was upregulated in PDGC and contributed to cell proliferation, migration, invasion and wound healing, whereas its inhibition in PDGC facilitated cell apoptosis. Yes LINC02535 expression was upregulated in PDGC and contributed to cell proliferation, migration, invasion and wound healing, whereas its inhibition in PDGC facilitated cell apoptosis. 34125981 LINC02535 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(miR-30a-5p/GALNT3 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that LINC02535 was increased in LUAD tissues and cells, and LINC02535 was correlated with the poor prognosis of LUAD patients. miR-30a-5p acts as a tumor suppressor in LUAD by targeting GALNT3. LINC02535 acts as a competing endogenous RNA (ceRNA) to interact with miR-30a-5p, thereby upregulating the expression of GALNT3, enhancing the function of MUC1, and activating the NF-κB signaling pathway, promoting the malignant progression of LUAD cells. Yes We also demonstrated that LINC02535 might function as the sponge of miR-30a-5p to up-regulate GALNT3, and consequently promote the proliferation and metastasis of LUAD. 35852407 LINC02532 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The qRT-PCR assay demonstrated that the LINC02532 expression level was significantly upregulated in the GC cell lines and 52 paired tissues. Kaplan-Meier survival analysis based on The Cancer Genome Atlas data showed that patients with higher LINC02532 expression had poorer prognosis than those with lower LINC02532 expression. The correlation analysis between expression and clinicopathological features revealed that high expression of LINC02532 was associated with a high TNM stage (P = 0.008) and poor differentiation grade (P = 0.023). Yes Functional experiments showed that LINC02532 promoted GC cell proliferation, migration, and invasion. 30788037 LINC02499 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR LINC02499 expression was remarkably decreased in HCC tissues compared to adjacent non-tumor tissues based on TCGA (P < 0.001) and GEO databases (P < 0.001) and our HCC cohort (P < 0.001). Decreased LINC02499 was also significantly associated with poorer overall survival in both the TCGA database (P = 0.009) and our HCC cohort (P = 0.002). Furthermore, the receiver operating characteristic analysis indicated that LINC02499 showed a good performance in HCC diagnosis (area under the curve = 0.879, P < 0.001), and both sensitivity and specificity were 83.8%. Yes In addition, up- and downregulated LINC02499 significantly impacted proliferation, migration, and invasion abilities of HCC cells in vitro. 32039538 LINC02475 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Expression(highly expressed) qRT-PCR LINC02475 expression was elevated in HCC, performed well in the diagnosis, and independently predicts poor overall survival (hazard ratio = 1.389, 95% confidence interval = 1.047-1.843, p = 0.023), as well as progression-free survival (hazard ratio = 1.396, 95% confidence interval = 1.016-1.917, p = 0.040) of HCC patients. LINC02475 expression was elevated in HCC, performed well in the diagnosis, and independently predicts poor overall survival (hazard ratio = 1.389, 95% confidence interval = 1.047-1.843, p = 0.023), as well as progression-free survival (hazard ratio = 1.396, 95% confidence interval = 1.016-1.917, p = 0.040) of HCC patients. Yes Moreover, LINC02475 enhanced the tumorigenic pathways necessary for cell stemness, DNA replication required for cell proliferation, epithelial-mesenchymal transition involved in metastasis, and DNA damage repair pathways that drove cell radioresistance and cisplatin resistance, thus promoting HCC progression. 36118852 LINC02474 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(GZMB) In Vivo Experiment//Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//FISH//RNA-seq//Invasion Assay The expression of LINC02474 was significantly up-regulated in CRC tissues. Besides, down-regulation of LINC02474 promoted the expression of GZMB, and interference of GZMB could increase the metastatic abilities of CRC cells while reducing apoptosis. Yes Moreover, depletion of LINC02474 damaged the metastatic abilities of CRC cells in vivo and in vitro while boosting apoptosis. Besides, up-regulation of LINC02474 could promote migration and invasion, while apoptosis was inhibited in CRC cells. 33898319 LINC02041 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] CCK8//qPCR//Western Blot The results illustrated that RP11-567G11.1 was significantly Expression[Expression[up-expression]-expression]-regulated in poorly differentiated pancreatic cancer tissues as compared to its expression in non-tumor tissues. Yes Additionally, depletion of RP11-567G11.1 in pancreatic cancer cells inhibited proliferation and cell cycle progression, induced apoptosis, sExpression[Expression[up-expression]-expression]pressed the stem cell-like phenotype, and increased sensitivity to gemcitabine. 30802827 LINC02023 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Interaction[PTEN ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//IHC This study aims to show that long noncoding RNA (lncRNA) Linc02023 aberrant downregulation in colorectal cancer correlates positively with the expression of PTEN and CDKN2B but negatively with the tumor size in patients and xenografted mouse models. Mechanistically, Linc02023 specifically binds to PTEN and blocks its interaction with and ubiquitination by WWP2, stabilizing it and suppressing its downstream expression. In conclusion, this study demonstrates that lncRNA Linc02023 may serve as a novel therapeutic target by restoring the PTEN tumor suppressor activity. Yes CDKN2B but negatively with the tumor size in patients and xenografted mouse models. The gain- and loss-of-function investigation reveals that Linc02023 suppresses the proliferation of colorectal cancer cells in vitro and in vivo with apoptosis promotion and cell cycle rearrangement. 30849479 LINC01980 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction[GADD45A ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Microarray In this study, we identified a novel lncRNA LINC01980, located in both the cytoplasm and nucleus, which was significantly upregulated in esophageal squamous cell carcinoma (ESCC) tissues through microarray profiling. Further experiments demonstrated that GADD45A promoted ESCC cell growth, indicating that GADD45A may be a downstream target of LINC01980. Further analysis revealed that LINC01980 overexpression was positively correlated with deeper invasion of cancer, positive lymph node metastasis, and advanced TNM stage. Yes In vitro and in vivo experiments demonstrated that LINC01980 promoted ESCC growth. 30935686 LINC01980 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma esophageal cancer cells and ESCC tissues regulation[miR-190a-5p/MYO5A pathway] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay The high expression of LINC01980 was detected in ESCC tissues and cells, and predicted poor prognosis.Therefore, these findings suggest that LINC01980 may act as an oncogenic lncRNA in ESCC and LINC01980/miR-190a-5p/MYO5A pathway contributes to the development of ESCC. The high expression of LINC01980 was detected in ESCC tissues and cells, and predicted poor prognosis. Yes LINC01980 promoted the cell proliferation, migration, invasion ability and epithelial-mesenchymal transition (EMT) progress in ESCC cells. 32325088 LINC01711 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma The tumor tissues and paired normal adjacent tissues Interaction(miR-326/FSCN1 axis) qRT-PCR//RIP//Western Blot In this study, we detected high expression of lncRNA LINC01711 in ESCC tissues and was associated with poor prognosis. Linc01711 was identified as a competitive endogenous RNA that suppressed miR-326, and up-regulated the expression of fascin actin-bundling protein 1 (FSCN1). In this study, we detected high expression of lncRNA LINC01711 in ESCC tissues and was associated with poor prognosis. Yes Silencing LINC01711 can inhibit the proliferation, migration, invasion, and growth of ESCC cell lines, and induce apoptosis. 34370713 LINC01711 LncRNA Homo sapiens Glioblastoma glioma cells, GBM tissues Interaction( miR-34a/ZEB1) qRT-PCR//ChIP//Western Blot We show that LINC01711 expression is significantly upregulated in GBM tissues and is associated with poor overall survival of GBM patients. In addition, LINC01711 depletion sensitizes glioma cells to Temozolomide (TMZ) induced apoptosis by inhibiting ZEB1 expression. LINC01711 functions as a competing endogenous RNA for miR-34a and promotes ZEB1 expression to regulate invasion. We show that LINC01711 expression is significantly upregulated in GBM tissues and is associated with poor overall survival of GBM patients. Yes Loss-of-function studies illustrate that LINC01711 promotes proliferation, migration, and invasion in GBM. 36341927 LINC01705 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues interaction[binding to miR-186-5p] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Our findings revealed high LINC01705 expression in breast cancer tissues relative to adjacent non-cancerous tissues (n = 40, P < 0.001). In conclusion, our results suggest that LINC01705 is implicated in the progression of breast cancer via competitively binding to miR-186-5p as a competing endogenous RNA (ceRNA), thereby regulating TPR expression. Yes Overexpression of LINC01705 notably enhanced cell migration and proliferation in breast cancer. 32849791 LINC01705 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cell lines regulation[miR-4722-3p/P2RY8 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our results demonstrated that the expression of RP11?400N13.3 was significantly upregulated in both colorectal cancer tissues and cell lines as compared to normal adjacent tissues and normal colonic epithelial cells by RT?qPCR, respectively. In conclusion, our results revealed that RP11‑400N13.3 promoted colorectal cancer progression via modulating the miR‑4722‑3p/P2RY8 axis, thus suggesting RP11‑400N13.3 as a potential therapeutic target for the treatment of colorectal cancer. Upregulation of RP11?400N13.3 was found to be correlated with a poor overall survival rate. Yes Functional studies revealed that RP11?400N13.3 facilitated the proliferation, migration, invasion and tumor growth of colorectal cancer cells while inhibiting the apoptosis of cancer cells in vitro and in vivo. 32901883 LINC01679 LncRNA Homo sapiens Prostatic Neoplasms PCa cells Interaction(miR-3150a-3p/SLC17A9 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay LINC01679 regulated miR-3150a-3p level by sponging it. Importantly, miR-3150a-3p overexpression was related to the increased proliferation and decreased apoptosis of PCa cells. Rescue assays suggested that miR-3150a-3p mimics rescued the repression on PCa progression mediated by LINC01679 upregulation, but SLC17A9 downregulation reversed the miR-3150a-3p inhibitor-mediated repression on PC progression. Yes According to our results, LINC01679 depletion promoted cell proliferation, metastasis, tumor growth, and inhibited cell apoptosis in vivo and in vitro, which was also associated with poor survival. 34900992 LINC01638 LncRNA Homo sapiens Breast Neoplasms TNBC tissues and cells interaction[c-Myc] Western Blot//ISH//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//IHC//Invasion Assay//ChIP Here, we demonstrated that LINC01638 is highly expressed in TNBC tissues and cells. Mechanistically, LINC01638 interacts with c-Myc to prevent SPOP-mediated c-Myc ubiquitination and degradation. LINC01638 overexpression predicts a poor outcome of breast cancer patients. Yes LINC01638 knockdown suppresses tumor proliferation and metastasis both in vitro and in vivo. 30002443 LINC01638 LncRNA Homo sapiens Breast Neoplasms breast cancer cells and tissues Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay Linc01638 was found to be remarkably overexpressed in HER2-positive breast cancer cells and tissues.Suppression of linc01638 enhanced cell apoptosis, as well as inhibited the growth and invasiveness of HER2-positive breast cancer cells in vitro and tumor progression and metastasis in vivo. Yes Suppression of linc01638 enhanced cell apoptosis, as well as inhibited the growth and invasiveness of HER2-positive breast cancer cells in vitro and tumor progression and metastasis in vivo. 29992881 LINC01638 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[Expression[Expression[highly expressed]-expression]-expression] CCK8//qRT-PCR LINC01638 lncRNA and glucose transporter 1 (GLUT1) were Expression[Expression[up-expression]-expression]regulated in tumor tissues compared with adjacent healthy tissues of patients with HCC. Yes Overexpression of LINC01638 lncRNA and GLUT1 promoted glucose Expression[Expression[up-expression]-expression]take, while LINC01638 lncRNA and GLUT1-knockExpression[down-expression] led to inhibited glucose Expression[Expression[up-expression]-expression]take of cells of HCC cell lines.Overexpression of LINC01638 lncRNA mediated the Expression[Expression[up-expression]-expression]regulation of GLUT1 expression and accelerated cell proliferation. 31516592 LINC01638 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues Regulation[TGF‑β signaling] qRT-PCR//ELISA In the present study, LINC01638 was significantly upregulated in tumor tissues compared with adjacent healthy tissues in the majority of patients with PDAC. Yes  LINC01638 overexpression promoted, while shRNA silencing inhibited, migration and invasion of cell of a PDAC cell line. 31702018 LINC01638 LncRNA Homo sapiens Thyroid Cancer, Papillary thyroid gland epithelial cell line Regulation(Axin2 / Wnt/β-catenin signaling pathway) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//cell invasion assay//Colony Formation Assay//IF We found that LINC01638 was upregulated in PTC cells compared with normal thyroid gland epithelial cell line Nthy-ori3-1. ELK1 could act as a transcription factor of LINC01638 and induce LINC01638 expression. LINC01638 silencing inhibited cell proliferation, migration and invasion, and obstructed the progress of TPC-1 cell cycle. LINC0163 silencing activated Axin2 while suppressing the expressions of β-catenin, Cyclin-D1 and c-MYC. Rescue experiment utilizing the transfection of Axin2 overexpression plasmid weakened LINC01638 overexpression-enhanced TPC-1 cell proliferation, metastasis, cell cycle progress and Wnt/β-catenin pathway. Yes LINC01638 silencing inhibited cell proliferation, migration and invasion, and obstructed the progress of TPC-1 cell cycle. LINC0163 silencing activated Axin2 while suppressing the expressions of β-catenin, Cyclin-D1 and c-MYC. Rescue experiment utilizing the transfection of Axin2 overexpression plasmid weakened LINC01638 overexpression-enhanced TPC-1 cell proliferation, metastasis, cell cycle progress and Wnt/β-catenin pathway. 34281460 LINC01638 LncRNA Homo sapiens laryngeal squamous cell carcinoma LSCC tissues Interaction(miR-523-5p/BATF3 axis) In Vivo Experiment//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay In the present study, we found that LINC01638 was highly expressed in LSCC tissues. In terms of mechanism, LINC01638 was found to sponge miR-523-5p and promote BATF3 expression. In summary, our results demonstrated that LINC01638/miR-523-5p/BATF3 axis plays a crucial function in initiating LSCC development and may be a potential target for tumor therapy. And LINC01638 expression was positively correlated with clinical stage and lymph node metastasis. Patients with LINC01638 high expression displayed a low survival rate. Yes Results from CCK8, colony formation, and transwell assays showed that LINC01638 knockdown suppressed the proliferation, migration and invasion of LSCC cells in vitro. Animal experiments indicated that LINC01638 silencing attenuated tumor growth in vivo. 33714208 LINC01635 LncRNA Homo sapiens Lung Neoplasms lung cancer and in non-small cell lung carcinoma (NSCLC) cell lines Interaction(miR-455-5p) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Next, it was confirmed that LINC01635 was upregulated significantly in samples from patients with lung cancer and in non-small cell lung carcinoma (NSCLC) cell lines. Furthermore, it was found that LINC01635 could bind to microRNA (miRNA or miR)-455-5p and regulate the expression of a series of miR-455-5p-targeting tumor-related genes. Knockdown of miR-455-5p partially rescued the progression of lung cancer cells that was suppressed by LINC01635 silencing. Yes Silencing LINC01635 suppressed the proliferation and metastasis of NSCLC cells in vitro and in vivo. 36420078 LINC01617 LncRNA Homo sapiens Esophageal Neoplasms esophageal cancer and adjacent tissues Regulation[AKT pathway] qRT-PCR We found that LINC01617 was overexpressed in esophageal cancer, and its expression was associated with poor prognosis of esophageal cancer. The Akt pathway may be involved in the regulation of cell activity in esophageal cancer. We found that LINC01617 was overexpressed in esophageal cancer, and its expression was associated with poor prognosis of esophageal cancer. Yes In vitro experiments confirmed that knockout of LINC01617 significantly inhibited the proliferation, migration and invasion of esophageal cancer cells. Moreover, knockout of LNC01617 can inhibit the growth of esophageal cancer in nude mice. 30120975 LINC01615 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Interaction(miR-3653-3p/ZEB2 ) qRT-PCR//Western Blot TCGA suggested that LINC01615 was high-expressed in colon cancer, as verified in clinical and cell samples, and patients with LINC01615 overexpression suffered from a poor prognosis. LINC01615, which was targeted by miR-3653-3p, partially offset the inhibitory effect of miR-3653-3p on colon cancer cells. The downstream target gene ZEB2 of miR-3653-3p was high-expressed in colon cancer. MiR-3653-3p was negatively correlated with LINC01615 or ZEB2, while LINC01615 was positively correlated with ZEB2. .TCGA suggested that LINC01615 was high-expressed in colon cancer, as verified in clinical and cell samples, and patients with LINC01615 overexpression suffered from a poor prognosis. Yes Silent LINC01615 blocked the malignant development of colon cancer cells through regulating related genes expressions, while overexpressed LINC01615 had the opposite effect. 34965191 LINC01615 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 502 HNSCC tissues and 44 normal tissues Expression(highly expressed) Migration Assay//MTT//Invasion Assay//Transwell Assay Clinical correlation analysis revealed that the LINC01615 increased with increasing the T stage, N stage, pathology grade, and clinical stage. Clinical correlation analysis revealed that the LINC01615 increased with increasing the T stage, N stage, pathology grade, and clinical stage. Yes Functionally, silencing of LINC01615 suppresses cell proliferation, invasion, and migration in HEP-2 and TU212 cells. 35794984 LINC01614 LncRNA Homo sapiens Stomach Neoplasms GC cases and GC cell lines Regulation Other In contrast, the lncRNA-based subtype 1 (L1) has the best survival outcome, while LINC01614 expression further segregated a subgroup of L1 cases with worse survival and increased chance of developing distal metastasis. Yes We demonstrated that LINC01614 over-expression is an independent prognostic factor in L1 and network-based functional prediction implicated its relevance to cell migration. Over-expression and CRISPR-Cas9-guided knockout experiments further validated the functions of LINC01614 in promoting GC cell growth and migration. 33742127 LINC01614 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Expression(highly expressed) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Cell Cycle Assay//Colony Formation Assay//Transwell Assay LINC01614 expression was identified and found to be upregulated in GC tissues and cells. Yes The study findings revealed that LINC01614 promoted cell proliferation, migration, invasion, and epithelial-mesenchymal transition. Knockdown of LINC01614 arrested cell cycle distribution at the G2/M phase.Further, LINC01614 also promoted tumor growth in vivo. 34691143 LINC01614 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Chinese population Mutation(rs16854802, rs3113503 ) CCK8//qRT-PCR In this study, we found that rs16854802 A > G (odds ratio [OR] = 1.42, 95% confidence interval [CI]: 1.22-1.77, p < 0.001) and rs3113503 G > C (OR = 1.38, 95% CI: 1.15-1.64, p < 0.001) in LINC01614 increased the risk of HNSCC in the Chinese population. Functional bioinformatic analysis and luciferase reporter assay revealed that rs3113503 G > C variant disrupted the binding of miRNA-616-3p to LINC01614, which resulted in the increased expression of LINC01614. Mechanistically, allele C of rs3113503 in LINC01614 was more effective than allele G in activating the PI3K/AKT signaling pathway. Moreover, the reduced expression of LINC01614 also inhibited the activation of the PI3K/AKT signaling pathway. Further analysis of the TCGA database demonstrated that the upregulated LINC01614 in HNSCC cancer tissues was associated with poor prognostic in HNSCC patients. Yes In vitro experiments showed that knockdown of LINC01614 inhibited the proliferation, invasion, and migration ability of HNSCC cells. 35687049 LINC01614 LncRNA Homo sapiens Esophageal Neoplasms EC cell Regulation qRT-PCR//Transwell Assay And we found that only LINC01614 was concerned with a candidate prognostic signature in EC. Yes The results of CCK8 and Transwell assays showed that suppression of LINC01614 inhibited EC cell proliferation and migration. 35116503 LINC01748 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR‑520a‑5p/HMGA1 pathway ) Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay Data from The Cancer Genome Atlas dataset and patients recruited into the present study showed that LINC01748 was overexpressed in NSCLC. Mechanistically, LINC01748 could act as a competing endogenous (ce)RNA to sponge microRNA(miR)‑520a‑5p, to increase the expression level of the target gene, high mobility group AT‑hook 1 (HMGA1) in the NSCLC cell lines. Furthermore, rescue experiments illustrated that the functions exerted by LINC01748 knockdown were negated by miR‑520a‑5p inhibition or HMGA1 overexpression. Patients with high LINC01748 mRNA expression level had shorter overall survival rate compared with that in patients with low LINC01748 mRNA expression level. Yes Then, knockdown of LINC01748 mRNA expression level reduced cell proliferation, migration and invasion, but increased cell apoptosis in vitro. Knockdown of LINC01748 also reduced tumor growth in vivo. 34970695 LINC01783 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC cells (SCC1, Cal27, UM1 and SCC4) and 22 TSCC cases Interaction(miR-199b-5p ) Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay In this research, we indicated that LINC01783 was up-regulated in TSCC cells (SCC1, Cal27, UM1 and SCC4) when compared to NHOK cell.RT-qPCR analysis indicated that LINC01783 was overexpressed in 22 TSCC cases (73.3%, 22/30) compared with no-tumour specimens.LINC01783 level was up-regulated in TSCC specimens when compared to no-tumour specimens.Overexpression of LINC01783 sponged miR-199b-5p in TSCC cell and elevated expression of LINC01783 inhibited miR-199b-5p expression. Moreover, we illustrated that miR-199b-5p was down-regulated in TSCC cells and specimen and LINC01783 level was up-regulated in TSCC specimens when compared to no-tumour specimens. Yes Ectopic expression of LINC01783 promoted TSCC cell cycle and growth and EMT progression in both TSCC cell SCC1 and Cal27. 34363308 LINC01783 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell lines Regulation(Notch pathway and sponging miR-432-5p) RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay LINC01783 was found remarkably increased in NSCLC cell lines, and down-regulation of LINC01783 suppressed cell proliferation, migration and invasion. Then, we discovered Notch pathway was related to the progression of NSCLC, and DLL-1 expression was reduced by LINC01783 knockdown. Furthermore, DLL-1 overexpression could counteract the suppressive effects of LINC01783 down-regulation on the growth of NSCLC cells. MiR-432-5p was observed to be the mutual miRNA that could bind with both LINC01783 and DLL-1. Overexpression of miR-432-5p inhibited DLL-1 expression. In the rescue assays, miR-432-5p depletion offset the impacts of LINC01783 knockdown, and then DLL-1 silence recovered the influence of miR-432-5p down-regulation on NSCLC cell growth. Yes Then, we discovered Notch pathway was related to the progression of NSCLC, and DLL-1 expression was reduced by LINC01783 knockdown. 33902591 LINC01857 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-2052/CENPQ axis) qRT-PCR The results showed that LINC01857 and CENPQ were highly expressed in BC tissues and cells, while miR-2052 was contrarily expressed. In vitro study showed that low expression of linc01857 could inhibit the migration ability and vascularization of BC cells, and mir-2052 inhibitor partially restored the effect of si-LINC01857 on the migration ability and vascularization of BC cells. Likewise, inhibition of CENPQ can partially rescue the effects of miR-2052 inhibitor on the migration ability and vascularization of BC cells. In vivo studies showed that down-regulation of LINC01857 notably suppressed tumor growth and angiogenesis in nude mice. The miR-2052 inhibitor partially restored the effects of si-LINC01857. Yes In vitro study showed that low expression of linc01857 could inhibit the migration ability and vascularization of BC cells, and mir-2052 inhibitor partially restored the effect of si-LINC01857 on the migration ability and vascularization of BC cells. Likewise, inhibition of CENPQ can partially rescue the effects of miR-2052 inhibitor on the migration ability and vascularization of BC cells. In vivo studies showed that down-regulation of LINC01857 notably suppressed tumor growth and angiogenesis in nude mice. The miR-2052 inhibitor partially restored the effects of si-LINC01857. 36046633 LINC01977 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction( TGF-β/SMAD3) IHC//Western Blot//ISH//qPCR//FISH//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//EdU Staining//IF We found that LINC01977, a cancer-testis lncRNA, was hijacked by SE, which promoted proliferation and invasion both in vitro and in vivo.LINC01977 interacted with SMAD3 to induce its nuclear transport, which facilitated the interaction between SMAD3 and CBP/P300, thereby regulating the downstream target gene ZEB1. Additionally, SMAD3 up-regulated LINC09177 transcription by simultaneously binding the promoter and SE, which was induced by the infiltration of M2-like tumor-associated macrophages (TAM2), subsequently activating the TGF-β/SMAD3 pathway. Moreover, LINC01977 expression was positively correlated with TAM2 infiltration and SMAD3 expression, especially in early-stage LUAD. Higher chromatin accessibility in the SE region of LINC01977 was observed with high expression of TGF-β. Early-stage LUAD patients with high LIN01977 expression had a shorter disease-free survival. Yes We found that LINC01977, a cancer-testis lncRNA, was hijacked by SE, which promoted proliferation and invasion both in vitro and in vivo. 35982471 LINC01969 LncRNA Homo sapiens Ovarian Neoplasms Ovarian Cancer tissues interaction[LINC01969/miR-144-5p/LARP1 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay The results of the current study showed that LINC01969 was dramatically upregulated in OC, and patients with lower LINC01969 expression levels tended to have better overall survival. In conclusion, the LINC01969/miR-144-5p/LARP1 axis is a newly identified regulatory signaling pathway involved in OC progression. The results of the current study showed that LINC01969 was dramatically upregulated in OC, and patients with lower LINC01969 expression levels tended to have better overall survival. Yes Further experiments demonstrated that LINC01969 promoted the migration, invasion, and proliferation of OC cells in vitro and sped up tumor growth in vivo. 33614632 LINC01963 LncRNA Homo sapiens Pancreatic Carcinoma pancreatic carcinoma tissues and cell lines interaction[miR-641/TMEFF2] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay lncRNA LINC01963 was confirmed to be lower expressed in pancreatic carcinoma tissues and cell lines.Long non-coding RNA LINC01963 inhibits progression of pancreatic carcinoma by targeting miR-641/TMEFF2. Yes By up-regulating the expression of lncRNA LINC01963 in pancreatic carcinoma cell lines, colony number, cell cycle, proliferation and invasion were inhibited, while apoptosis was improved. 32559621 LINC01939 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[ as a ceRNA for miR-17-5p to regulate EGR2 expression] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that LINC01939 expression was significantly downregulated in GC tissues and cell lines. Taken together, these results suggested that LINC01939 repressed GC invasion and migration by functioning as a ceRNA for miR-17-5p to regulate EGR2 expression. Our findings provided a novel prognostic marker and therapeutic target for GC patients Low expression of LINC01939 was correlated with tumor metastasis and shorter survival in GC patients. Yes Functionally, LINC01939 overexpression remarkably inhibited the invasion and migration of GC cells in vitro and in vivo. 30683847 LINC01939 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines regulation[ down-regulation of miR-154] qRT-PCR//Wound Healing Assay//Western Blot LINC01939 was down-regulated in RCC tissues. LINC01939 overexpression impeded proliferation and migration, and induced apoptosis.Up-regulation of LINC01939 inhibited proliferation and migration of RCC cells by down-regulating miR-154. Yes LINC01939 overexpression impeded proliferation and migration, and induced apoptosis. 32138544 LINC01929 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissue samples and cell lines Interaction(miR-137-3p/FOXC1 Axis) Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay Our findings demonstrated that LINC01929 was highly expressed in OSCC tissue samples and cell lines, whereas miR-137-3p expression was downregulated. Mechanistically, LINC01929 acted as a sponge for miR-137-3p to elevate FOXC1 expression, which is the target of miR-137-3p. In addition, downregulated miR-137-3p expression rescued the suppressive behaviors of LINC01929 knockdown on the biological behaviors of OSCC cells. Taken together, LINC01929 functioned as a tumor-promoting lncRNA via the miR-137-3p/FOXC1 axis in OSCC, suggesting novel targets for OSCC therapy. Yes LINC01929 acted as a carcinogenic lncRNA with accelerated OSCC cell proliferation, migration and invasion, and suppression of apoptosis. We further indicated that LINC01929 facilitated tumor growth in xenograft mouse models. 33968763 LINC01857 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Regulation[regulates CREB1 ] qRT-PCR In this study, we found that LINC01857 was highly expressed in breast cancer tissues and cells (p < 0.05). Taken together, our findings demonstrated that LINC01857 promoted breast cancer development by promoting H3K27Ac and CREB1 transcription via enhancing CREBBP enrichment in the CREB1 promoter region. High LINC01857 expression predicted poor prognosis in breast cancer patients. Yes Functionally, LINC01857 silencing impaired proliferation and enhanced apoptosis of breast cancer cells ( p < 0.05).Decreased LINC01857 inhibited breast cancer cells migration and invasion ability ( p < 0.05). 30628071 LINC01857 LncRNA Homo sapiens pancreatic adenocarcinoma PDAC tissues and cells Interaction( miR-19a-3p/SMOC2) CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay LINC01857 levels were significantly elevated in PDAC. MiR-19a-3p was a downstream target of LINC01857, and miR-19a-3p levels were significantly decreased in PDAC cells. In addition, SMOC2 expression had a negative correlation with that of miR-19a-3p, and SMOC2 was a downstream target of miR-19a-3p. Furthermore, SMOC2 upregulation partially abolished the inhibitive influence of LINC01857 downregulation on cell proliferation, migration, invasion, and the EMT process. Yes Knockdown of LINC01857 significantly restrained the proliferation, migration, invasion, and Epithelial-Mesenchymal Transition (EMT) process of PDAC cells. 35662010 LINC01787 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines(MDA-MB-231,MCF-7) Interaction[Disrupting miR-125b ] RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay LINC01787 is up-regulated in breast cancer tissues and is associated with advanced stages and poor survival.In conclusion, our findings identified a novel up-regulated and oncogenic lncRNA LINC01787 in breast cancer, which binds pre-miR-125b and represses mature miR-125b generation. LINC01787 is up-regulated in breast cancer tissues and is associated with advanced stages and poor survival. Yes Functional assays showed that LINC01787 promotes breast cancer cell proliferation and migration and breast cancer xenograft growth in vivo, which is abolished by the mutation of pre-miR-125b binding sites on LINC01787 or overexpression of miR-125b. 31750242 LINC01857 LncRNA Homo sapiens Glioma glioma tissues Regulation[miR-1281/TRIM65 axis] CCK8//qPCR//Luciferase Report Assay//Transwell Assay In the present research, LINC01857 levels were found to be upregulated in glioma. Collectively, this study first demonstrated that a novel LINC01857/miR-1281/TRIM65 signaling regulates glioma progression. In addition, LINC01857 expression is negatively correlated with survival rate in glioma patients. Yes Functional investigation revealed that LINC01857 downregulation impaired glioma proliferation and invasiveness. Furthermore, LINC01857 knockdown led to repressed growth of glioma in vivo. 31049960 LINC01857 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues and cells Regulation(PI3K/mTOR pathway and EMT process&miR-141-3p/MAP4K4 axis) qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis Yes Bioinformatics analysis and luciferase reporter assay confirmed that LINC01857 may serve as a sponge for miR-141-3p and miR-141-3p may target MAP4K4. Mechanically, the regulatory action of miR-141-3p/MAP4K4 on DLBCL cellular behaviors was regulated by LINC01857. 33311569 LINC01852-201 LncRNA Homo sapiens Stomach Neoplasms GC tissues Regulation[Wnt/β-catenin signaling pathway] qRT-PCR We found that expression of Wnt2b, β-catenin, cyclinD1, N-cadherin, vimentin, and snail was increased in GC tissues, while expression of ENST00000434223 and E-cadherin was decreased. Yes Furthermore, the rate of apoptosis was decreased and cell proliferation, invasion and migration were increased in response to downregulation of ENST00000434223. By contrast, upregulation of ENST00000434223 exhibited the opposite effects in MKN-45 cells. 30138664 LINC01852-201 LncRNA Homo sapiens Kidney Neoplasms renal cancer tissues and para-cancerous tissues ,cell lines(786-O,ACHN) Regulation[Wnt/hygro-catenin signaling pathway] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot "The results indicated that ENST00000434223 was lowly expressed in renal carcinoma tissue (Figure 1A) when compared with paired para-cancerous tissues. In addition, the expression level of ENST00000434223 786-o and ACHN cells was notably lower than that of proximal tubule epithelial cell line hk-2 .At the same time, interference or overexpression of ENST00000434223 could affect the expression level of proteins related to the Wnt/β-catenin signal pathway." Yes In addition, down-regulating ENST00000434223 could enhance the viability, metastasis and invasiveness of renal cancer cells. However, overexpressing ENST00000434223 remarkably weakened the above cell functions. 31486486 LINC01833 LncRNA Homo sapiens Urinary Bladder Neoplasms cells Interaction(miR-129-5p/PROM2 axis) qRT-PCR//RIP RP11-89 promoted cell proliferation, migration and tumorigenesis and inhibited cell cycle arrest via the miR-129-5p/PROM2 axis. Yes RP11-89 promoted cell proliferation, migration and tumorigenesis and inhibited cell cycle arrest via the miR-129-5p/PROM2 axis. 34728613 LINC01833 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissue regulation[MiR-519e-3p/S100A4 Axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay qRT-PCR assay further revealed significantly higher expression of linc01833 in LUAD tissue than the adjacent normal tissue (Figure 1C).Rescue assay demonstrated that linc01833 acted on the miR-519e-3p/S100A4 axis. Yes Linc01833 OE can significantly improve proliferation as well as invasion ability of LC cells and promote the EMT process. 33173348 LINC01819 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(KLF5) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//qRT-PCR//FISH//ChIP-seq//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//EdU Staining Here, we demonstrate that lncRNA KPRT4 promotes BLBC cell proliferation in vitro and in vivo. Mechanistically, KLF5 directly binds to the promoter of KPRT4 to promote KPRT4 transcription. Reciprocally, KPRT4 recruits the YB-1 transcription factor to the KLF5 promoter by interacting with YB-1 at its 5' domain and forming an RNA-DNA-DNA triplex structure at its 3' domain, resulting in enhanced transcription of KLF5 and ultimately establishing a feedforward circuit to promote cell proliferation. Moreover, the antisense oligonucleotide (ASO)-based therapy targeting KPRT4 substantially attenuated tumor growth in vivo. Clinically, the expression levels of YB-1, KLF5 and KPRT4 are positively correlated in clinical breast specimens. Yes Here, we demonstrate that lncRNA KPRT4 promotes BLBC cell proliferation in vitro and in vivo. Mechanistically, KLF5 directly binds to the promoter of KPRT4 to promote KPRT4 transcription. Reciprocally, KPRT4 recruits the YB-1 transcription factor to the KLF5 promoter by interacting with YB-1 at its 5' domain and forming an RNA-DNA-DNA triplex structure at its 3' domain, resulting in enhanced transcription of KLF5 and ultimately establishing a feedforward circuit to promote cell proliferation. Moreover, the antisense oligonucleotide (ASO)-based therapy targeting KPRT4 substantially attenuated tumor growth in vivo. Clinically, the expression levels of YB-1, KLF5 and KPRT4 are positively correlated in clinical breast specimens. 35259457 LINC01793 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cancer tissues and cell lines Expression(highly expressed) qRT-PCR//MTT//Transwell Assay LINC01793 level was upregulated in cancer tissues and cell lines of OSCC, and its expression was increased in cancer tissues from patients with lymph node metastasis. Moreover, high LINC01793 level was positively correlated with T category, TNM stage, lymph node metastasis, and local recurrence. Yes Functionally, cell proliferation, invasion and migration of SCC9 and Cal27 cells were decreased after knockdown of LINC01793. Consistently, silence of LINC01793 induced G0/G1 cell cycle arrest in OSCC cells. 33713982 LINC01260 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung regulation[miR-562/CYLD/NF-κB Pathway] Western Blot//CCK8//qRT-PCR//ELISA//Colony Formation Assay//Transwell Assay In NSCLC tissues and cell lines, LINC01260 expression was downregulated, which corresponded to a lower survival rate of patients with NSCLC. In NSCLC tissues and cell lines, LINC01260 expression was downregulated, which corresponded to a lower survival rate of patients with NSCLC. Yes Knockdown of LINC01260 accelerated the proliferation, colony formation, and migration of NSCLC cells. 33116647 LINC01260 LncRNA Homo sapiens Non-alcoholic Fatty Liver Disease OA group, LO2 cells Interaction(RXRB ) qRT-PCR//Oil Red O Staining//Transfection//RNA-seq Fluorescence quantitative PCR showed that the expression of LINC01260 in the OA group was downregulated by 0.35 ± 0.07-fold (P < 0.05). The formation of lipid droplets in LO2 cells of the LINC01260 GOF group decreased significantly (P < 0.05). Yes Overexpression of LINC01260 significantly induced RXRB transcription (P < 0.05) and translation, and RXRB silence attenuated the lipids decrease induced by LINC01260 overexpression. 35016686 LINC01255 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow cells of AML patients Interaction(BMI1/MCP-1/ p53-p21 ) qRT-PCR//Western Blot LncRNA LINC01255 is highly expressed in bone marrow cells of AML patients, CD34+ cells of MDS-AML patients and AML cell lines and the higher expression of LINC01255 is associated with poor survival rate of AML patients. LINC01255 can interact with BMI1 and repress the transcription of MCP-1 to active p53-p21 pathway, thus inhibiting the senescence of human mesenchymal stromal and proliferation of acute myeloid leukemia cell. LncRNA LINC01255 is highly expressed in bone marrow cells of AML patients, CD34+ cells of MDS-AML patients and AML cell lines and the higher expression of LINC01255 is associated with poor survival rate of AML patients. Yes LINC01255 can interact with BMI1 and repress the transcription of MCP-1 to active p53-p21 pathway, thus inhibiting the senescence of human mesenchymal stromal and proliferation of acute myeloid leukemia cell. 33405050 LINC01023 LncRNA Homo sapiens Hepatoblastoma hepatoblastoma tissue and cell lines Interaction(miR-378a-5p/WNT3 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay LINC01023 was significantly upregulated in hepatoblastoma tissue and cell lines rather than in adjacent normal hepatic tissue and QSG7701 cell lines. To the best of our knowledge, this study is the first study demonstrating the role of LINC01023 in hepatoblastoma tumorigenesis through the LINC01023/miR-378a-5p/Wnt3 axis. Yes LINC01023 silencing attenuated cell proliferation, colony formation and increased cell apoptosis. Conversely, LINC01023 upregulation results in significant increase in cell proliferation, and colony formation activities however, a significant reduction in apoptosis activity was reported. Interaction between the LINC01023 and WNT3 was confirmed by dual luciferase assay. Xenograft animal tumorgenicity test confirmed the in-vivo tumorigenesis potential of LINC01203. 36576714 LINC01018 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-182-5p) Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis//Transwell Assay LINC01018 was significantly down-regulated in glioma tissues and cell lines. LINC01018 directly target to miR-182-5p. Forced up-regulation of miR-182-5p reversed the inhibitory effects on proliferative and metastatic abilities of glioma cells with LINC01018 overexpression. Lastly, the bioinformatics analyses revealed that LINC01018/miR-182-5p axis mediated a cluster of downstream genes (ADRA2C, RAB6B, RAB27B, RAPGEF5, STEAP2, TAGLN3, and UNC13C), which were potential key factors in the development of glioma. Yes Overexpression of LINC01018 dramatically inhibited cell proliferation, migration, and invasion and reverse EMT process in glioma. 36094613 LINC01018 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(LncRNA LINC01018/miR-942-5p/KNG1 axis) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay MiR-942-5p targeted KNG1, and LINC01018 sponged miR-942-5p. The high survival rate of patients was related to low miR-942-5p level. MiR-942-5p was highly expressed, whereas KNG1 was lowly expressed in glioma. MiR-942-5p was negatively correlated with KNG1. The levels of miR-942-5p and KNG1 were decreased by LINC01018 knockdown, and LINC01018 expression was suppressed by miR-942-5p mimic. MiR-942-5p inhibitor, KNG1, and LINC01018 had the opposite effect to miR-942-5p mimic. Yes Silent LINC01018 or KNG1 and miR-942-5p mimic enhanced the migration, invasion, and proliferation of glioma cells, and regulated the expressions of metastasis-related and proliferation-related genes. LINC01018 knockdown and miR-942-5p mimic promoted glioma tumor growth in mice. 36550594 LINC01013 LncRNA Homo sapiens Cardiovascular Diseases endothelial cells Regulation(RAD22/VEGFA) qRT-PCR//Wound Healing Assay//RNA Pull-Down//Western Blot In our study we show that long non-coding RNA Aerrie (linc01013) contributes to the DNA signaling and repair mechanism. Aerrie associates with YBX1 and together they act as important factors in DNA damage signaling and repair. Yes Silencing of Aerrie in endothelial cells impairs angiogenesis, migration, and barrier function. 33505972 LINC01004 LncRNA Homo sapiens Pituitary Neoplasms PA cells Interaction(miR-323a-3p/136-5p/RCN2 axis) In Vivo Experiment//RNA Pull-Down//IHC//Transfection//CCK8//qRT-PCR//Flow Cytometry//FISH//Luciferase Report Assay//Colony Formation Assay In this study, we discovered that long intergenic non-protein coding RNA 1004 (LINC01004) was aberrantly up-regulated in PA cells. By using bioinformatics tools and a series of mechanism assays, LINC01004 was identified to sponge miR-323a-3p/miR-136-5p to enhance the expression of RCN2 in PA. Yes Functional assays manifested that LINC01004 promoted malignant behaviors of PA cells in vitro and growth of PA in vivo. 35490653 LINC01003 LncRNA Homo sapiens Multiple Myeloma peripheral blood samples of MM patients Interaction(miR-33a-5p/PIM1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//MTT//Luciferase Report Assay//ELISA Low expression of LINC01003 was observed in MM cell lines and peripheral blood samples of MM patients. We then identified miR-33a-5p as a downstream target of LINC01003, and confirmed that PIM1 was a direct target gene of miR-33a-5p. Both high expression of miR-33a-5p and low expression of PIM1 reversed the suppressive effects of LINC01003 overexpression on cell adhesion and viability, and the promoting effect on apoptosis in MM cells. Yes Both LINC01003 up-regulation and miR-33a-5p down-regulation repressed cell viability and adhesion, and promoted apoptosis of MM cells. Moreover, LINC01003 suppressed the growth of xenograft tumor in mice. 33865032 LINC00997 LncRNA Homo sapiens Colorectal Neoplasms MCRC tissues Interaction(miR-512-3p) qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay Results revealed that LINC00997 was frequently overexpressed in MCRC tissues, which was positively related to the tumor metastasis and stage. Luciferase reporter assay confirmed that LINC00997 could target miR-512-3p. In conclusion, LINC00997 regulated the metastasis of CRC by targeting miR-512-3p, providing some insights into the regulatory mechanism of CRC. Results revealed that LINC00997 was frequently overexpressed in MCRC tissues, which was positively related to the tumor metastasis and stage. Yes Additionally, LINC00997 was significantly elevated in CRC cells and LINC00997 silencing inhibited the invasion, migration and EMT of CRC cells, which was restored by miR-512-3p inhibitor. 33570445 LINC00997 LncRNA Homo sapiens Carcinoma, Renal Cell KIRC tissues Regulation[LINC00997-STAT3-S100A11 axis] qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Western Blot In 18 cases of KIRC, we found that LINC00997 expression was greater in cancer tissues and metastases than in normal tissues.Consequently, the LINC00997-STAT3-S100A11 axis may promote the development of KIRC, and LINC00997 may represent a potential prognostic biomarker and therapeutic target for KIRC patients. These results revealed that S100A11 is positively associated with LINC00997 in KIRC, which is positively correlated with metastasis-associated molecules VIM, MMP2 and MMP7. Yes Our in vitro wound healing assay and Transwell tests demonstrated that interfering with either LINC00997 or S100A11 expression reduced migration of 786-O cells by inhibiting VIM, MMP2 and MMP7 expression. 31442606 LINC00996 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Regulation(JAK-STAT3) Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay Compared with adjacent normal lung tissues, Linc00996 was significantly downregulated in LUAD, and its expression was negatively correlated with T stage, N stage, and pathological stage. Via GSEA and ssGSEA, we observed that Linc00996 might be connected with immune infiltration in LUAD, and Linc00996 might inhibit tumorigenesis and metastasis by regulating antigen processing and presentation, JAK-STAT3, and cell adhesion molecular signaling pathways. Compared with adjacent normal lung tissues, Linc00996 was significantly downregulated in LUAD, and its expression was negatively correlated with T stage, N stage, and pathological stage. Yes An in vitro study suggested that enhanced Linc00996 expression could inhibit cell proliferation, clonal formation, migration, and invasion in LUAD cell lines. 36118847 LINC00994 LncRNA Homo sapiens Stomach Neoplasms GC tissues Regulation[regulating miR-765-3p] qRT-PCR//Luciferase Report Assay Compared to adjacent samples, the LINC00994 expression was increased in GC tissues by qRT-PCR assay. LINC00994 induced GC cell invasion and growth via modulating miR-765-3p. Yes Furthermore, Elevated expression of LINC00994 induced GC cell invasion, proliferation and cycle. 31737214 LINC00994 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues Regulation[miR-765-3p/RUNX2 axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Microarray//Transwell Assay Our microarray results first indicated long intergenic non-protein coding RNA 994 (LINC00994) as an upregulated long non-coding RNA (lncRNA) and miR-765-3p as a downregulated microRNA (miRNA) in pancreatic cancer tissues (Fold change ≥ 2 and P < 0.05; three paired samples).Furthermore, the expression of LINC00994 was negatively correlated with that of miR-765-3p in 10 pancreatic cancer specimens. Runt-related transcription factor 2 (RUNX2), a molecule that contributes to the aggressive behaviors of pancreatic cancer, was herein verified as a novel target for miR-765-3p. Like LINC00994, its expression was elevated in pancreatic cancers. Silencing of LINC00994 and RUNX2 reduced each other's expression in both Panc-1 and AsPC-1 cells. RUNX2 3'UTR and LINC00994 competed to bind miR-765-3p. Additionally, LINC00994-silenced cells regained their aggressive behaviors when miR-765-3p was antagonized, which was accompanied with RUNX2 re-expression. Yes We found that LINC00994 silencing inhibited the growth, migration and invasion, and promoted the G1 cell cycle arrest and apoptosis in Panc-1 and AsPC-1 cells. 30739523 LINC00993 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and paired peritumor tissue Expression[lower expressed] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Transwell Assay Subgroup analysis showed that LINC00993 was downregulated in breast cancer tissues when compared to its paired peritumor tissues in TNBC group Yes LINC00993 located mainly in the nucleus. LINC00993 suppressed TNBC growth both in vitro and in vivo. 31921620 LINC00993 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues,cell lines Expression[lower expressed] CCK8//qPCR//Western Blot LncRNA TCONS_l2_00002973 expression was lower in tumor tissue compared to paired adjacent tissue (p<0.001). Further in vitro experiments disclosed that lncRNA TCONS_l2_00002973 expression was reduced in various breast cancer cell lines compared to normal breast cell line LncRNA TCONS_l2_00002973 expression was lower in tumor tissue compared to paired adjacent tissue (p<0.001), and its low expression was associated with increased T stage (p=0.002), raised N stage (p=0.003) and advanced TNM stage (p=0.005) in TNBC patients. Poor OS was found in lncRNA TCONS_l2_00002973 low expression groExpression[Expression[up-expression]-expression] compared to lncRNA TCONS_l2_00002973 high expression groExpression[Expression[up-expression]-expression] (p=0.006). Yes lncRNA TCONS_l2_00002973 repressed cell proliferation and enhanced cells apoptosis in MDA-MB-231 cells. 31128002 LINC00992 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-361-5p/Twist1 ) qRT-PCR RT-qPCR revealed that LINC00992 was highly expressed in HCC tissues and cells. Our result showed that the expression of miR-361-5p was lower in the LINC00992 (+) group than in the LINC00992 (-) group. CCK-8 and Transwell showed that LINC00992 promoted HCC cell proliferation, migration, and invasion, whereas dual-luciferase reporter assay and RNA pull-down assay showed that LINC00992 combined with miR-361-5p to act as a miRNA decoy in HCC. RT-qPCR and Western blotting confirmed that LINC00992 upregulated the expression of the Twist1 gene in HCC cells by downregulating expression of miR-361-5p. CCK-8 and Transwell assays confirmed that LINC00992 promoted the proliferation, metastasis, and invasiveness of HCC cells by downregulating miR-361-5p levels and consequently upregulating Twist1 expression, implying that these three elements may be promising targets for HCC therapy. Yes CCK-8 and Transwell showed that LINC00992 promoted HCC cell proliferation, migration, and invasion, whereas dual-luciferase reporter assay and RNA pull-down assay showed that LINC00992 combined with miR-361-5p to act as a miRNA decoy in HCC. RT-qPCR and Western blotting confirmed that LINC00992 upregulated the expression of the Twist1 gene in HCC cells by downregulating expression of miR-361-5p. CCK-8 and Transwell assays confirmed that LINC00992 promoted the proliferation, metastasis, and invasiveness of HCC cells by downregulating miR-361-5p levels and consequently upregulating Twist1 expression, implying that these three elements may be promising targets for HCC therapy. 36084427 LINC00987 LncRNA Homo sapiens Osteosarcoma osteosarcoma cells Interaction(miR-376a-5p/FNBP1 ) qRT-PCR//Western Blot LINC00987 was found to be upregulated in osteosarcoma cells. In conclusions, this study suggests LINC00987 silencing inhibits osteosarcoma cell proliferation, migration, and invasion by sponging miR-376a-5p to regulate FNBP1 expression. Yes LINC00987 silencing suppressed proliferation, migration, and invasion of osteosarcoma cells. 35201476 LINC00987 LncRNA Homo sapiens Pulmonary Disease, Chronic Obstructive COPD tissues regulation[Let-7b-5p/SIRT1 Axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//ELISA LINC00987 expression was strikingly downregulated and let-7b-5p expression was obviously upregulated in COPD tissues and LPS-induced BEAS-2B cells compared with control groups.LINC00987 ameliorated COPD through modulating LPS-induced cell apoptosis, oxidative stress, inflammation and autophagy via sponging let-7b-5p to associate with SIRT1. Yes LINC00987 overexpression promoted BEAS-2B cells against LPS-mediated viability, apoptosis, oxidative stress, inflammation and autophagy, whereas these effects were attenuated by let-7b-5p mimic or SIRT1 knockdown. 33311978 LINC00976 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines Interaction[linc00976/miR-137/OTUD7B/EGFR axis] IP//Western Blot//ISH//Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//EdU Staining//Transwell Assay linc00976 expression was overexpressed in PC tissues and cell lines and was positively associated with poorer survival in patients with PC. Ultimately, OTUD7B mediates EGFR and MAPK signaling pathway, suggesting that linc00976/miR-137/OTUD7B/EGFR axis may act as a potential biomarker and therapeutic target for PC. linc00976 expression was overexpressed in PC tissues and cell lines and was positively associated with poorer survival in patients with PC. Yes Function studies revealed that linc00976 knockdown significantly suppressed cell proliferation, migration and invasion in vivo and in vitro, whereas its overexpression reversed these effects. 31747939 LINC00976 LncRNA Homo sapiens Cholangiocarcinoma CCA tissue samples and cell lines Interaction(miR-3202/GPX4 axis) RNA Pull-Down//Western Blot//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//EdU Staining Compared with normal controls, linc00976 was dramatically upregulated in CCA tissue samples and cell lines. Mechanistically, linc00976 competitively interacted with miR-3202 to upregulate GPX4 expression, thus contributing to the malignant biological behavior of CCA cells. Moreover, we demonstrated that JUND specifically interacts with the linc00976 promoter and activates linc00976 transcription. Accordingly, JUND promotes linc00976 transcription, and linc00976 plays a crucial role in accelerating CCA tumorigenesis and metastasis and inhibiting ferroptosis by modulating the miR-3202/GPX4 axis. Patients with CCA exhibiting high linc00976 expression had a highly advanced clinical stage, substantial lymph node metastasis, and poor overall survival. Yes Knockdown of linc00976 significantly repressed proliferation and metastasis and promoted ferroptosis of CCA cells both in vitro and in vivo, whereas linc00976 overexpression exerted the opposite effect. 36400758 LINC00974 LncRNA Homo sapiens Stomach Neoplasms Gastric Cancer tissues Interaction[upregulates CDK6] CCK8//qRT-PCR//Cell Cycle Assay//Western Blot The authors observed in this study that LINC00974 was upregulated in gastric cancer (GC) and positively correlated with CDK6.In GC tissues, LINC00974 and CDK6 were positively correlated. In GC cells, LINC00974 overexpression led to upregulated, whereas LINC00974 siRNA silencing led to downregulated CDK6. Survival analysis showed that high levels of LINC00974 and CDK6 predicted poor survival. Yes  Analysis of cell cycle progression and proliferation showed that LINC00974 and CDK6 overexpression promoted and siRNA silencing inhibited G1-S transition and cell proliferation. 31596614 LINC00974 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Interaction[downregulate miR-122] qRT-PCR//Transwell Assay//Western Blot The authors found that LINC00974 was upregulated in oral squamous cell carcinoma (OSCC) and predicted poor survival.Therefore, LINC00974 can downregulate miR-122 to upregulate RhoA in OSCC, thereby promoting cell invasion and migration. The authors found that LINC00974 was upregulated in oral squamous cell carcinoma (OSCC) and predicted poor survival. Yes In invasion and migration assay, miR-122 overexpression resulted in reduced, whereas LINC00974 and RhoA overexpression resulted in increased rate of cancer cell migration and invasion. 31702382 LINC01018 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML tissues Interaction(miR-499a-5p/PDCD4 ) qRT-PCR//Luciferase Report Assay LINC01018 and PDCD4 were downregulated in AML, while miR-499a-5p was upregulated. LINC01018 acted as a sponge of miR-499a-5p, and PDCD4 was demonstrated to be targeted by miR-499a-5p. Knockdown of miR-499a-5p suppressed AML cell proliferation and promoted AML cell apoptosis, but silencing PDCD4 abolished this effect. LINC01018 inhibited AML cell growth by modulating PDCD4 through suppression of miR-499a-5p, providing a feasible theoretical basis for the treatment of AML. Yes LINC01018-overexpression suppressed AML cell proliferation and induced AML cell apoptosis, while miR-499a-5p transfection reversed these effects. 34079594 LINC01048 LncRNA Homo sapiens Skin Neoplasms CSCC tissues Interaction[binding to TAF15 ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//EdU Staining//ChIP Obviously, LINC01048 was expressed higher in the CSCC tissues and recurrence tissues compared with that in adjacent normal tissues and non-recurrence tissues.In conclusion, USF1-induced upregulation of LINC01048 promoted CSCC by interacting with TAF15 to upregulate YAP1. Furthermore, Kaplan-Meier analysis revealed the negative correlation between LINC01048 expression and the overall survival and disease-free survival of CSCC patients. Yes Subsequently, functional assays were conducted to prove the inhibitory effect of silenced LINC01048 on the proliferation and apoptosis of CSCC cells. 30931936 LINC01106 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues Interaction(miR-34a-5p/MYCN Axis) In Vivo Experiment//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay LncRNA LINC01106 and MYCN expression were boosted and miR-34a-5p expression was reduced in GC cells and tissues compared to their controls. Yes Functionally, decreased lncRNA LINC01106 or increased miR-34a-5p restrained GC cells in viability, invasion, and migration in vitro. LINC01106 down-regulation suppressed tumor growth of mice in vivo. In terms of mechanism, lncRNA LINC01106 directly targeted miR-34a-5p and was inversely correlated with miR-34a-5p. 34550549 LINC01050 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction(miR-7161-3p to regulate SPZ1 expression) RNA Pull-Down//Northern Blot//Western Blot//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//IHC//Invasion Assay//ChIP LINC01050 was significantly up-regulated in gastric cancer, and its high expression was positively correlated with a poor prognosis. Moreover, mechanistic investigations revealed that LINC01050 functions as a molecular sponge to absorb cytosolic miR-7161-3p, which reduces the miR-7161-3p-mediated translational repression of SPZ1, thus contributing to gastric cancer progression. LINC01050 was significantly up-regulated in gastric cancer, and its high expression was positively correlated with a poor prognosis. Yes Furthermore, overexpression of LINC01050 was confirmed to promote gastric cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition in vitro and tumor growth in vivo. At the same time, its knockdown inhibited gastric cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition in vitro along with tumor growth and metastasis in vivo. 34749766 LINC01094 LncRNA Homo sapiens Glioma glioma patient tissues Interaction(miR-224-5p/CHSY1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//FISH//RIP//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Significantly, we revealed that the expression levels of LINC01094 were elevated in the glioma patient tissues compared to adjacent normal tissues. The LINC01094 expression was enhanced in the glioma cell lines. Thus, we conclude that lncRNA LINC01094 promotes glioma progression by modulating miR-224-5p/CHSY1 axis. Yes The depletion of LINC01094 inhibited cell viability and colony formation in the glioma cells. Meanwhile, the migration and invasion of glioma cells were impaired by the depletion of LINC01094. 34716872 LINC01094 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC cells and clinical tissues regulation[Upregulating SLC2A3 via MicroRNA-184] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//RIP//Flow Cytometry//Transwell Assay In ccRCC cells and clinical tissues, LINC01094 and SLC2A3 were highly expressed while miR-184 was lowly expressed. Taken together, silencing LINC01094 inhibited SLC2A3 expression by up-regulating miR-184, thereby inhibiting the development of ccRCC. Yes Silencing LINC01094, up-regulating miR-184, or reducing SLC2A3 inhibited the growth, migration, and invasion of ccRCC cells. Tumor growth was suppressed by silenced LINC01215 via reducing the expression of SLC2A3 via miR-184. 33173535 LINC01093 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[LINC01093-IGF2BP1-GLI1 axis] FISH//RNA Pull-Down//RIP We report a novel, liver-specific lncRNA LINC01093 that shows significant downregulation in HCC tissues.The liver-enriched lncRNA LINC01093 is a promising prognostic indicator for HCC patients, and the newly identified LINC01093-IGF2BP1-GLI1 axis shows potential for therapeutic targets in HCC. LINC01093 expression is inversely correlated with cancer embolus and HCC TNM stage and as a prognostic predictor for HCC patients. Yes LINC01093 overexpression significantly suppresses HCC cell proliferation and metastasis in vitro and in vivo. Conversely, its knockdown promotes HCC progression. 30790682 LINC01089 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-27a-3p/TET1 axis] CCK8//qRT-PCR//Luciferase Report Assay//BrdU//Transwell Assay LINC01089 down-regulation was observed in GC tissues and cell lines. LINC01089 impedes the proliferation, migration, and invasion of GC cells by adsorbing miR-27a-3p and up-regulating the expression of TET1. Low expression level of LINC01089 in GC tissues was markedly linked to larger tumor size, higher T stage, as well as lymphatic metastasis of the patients. Yes Functional experiments implied that LINC01089 overexpression impeded the proliferation, migration, as well as invasion of GC cells, whereas LINC01089 knockdown promoted the above malignant phenotypes. 33088215 LINC01089 LncRNA Homo sapiens Stomach Neoplasms GC cells interaction[binds to miR-145-5p] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay High LINC01089 expression was observed in GC cells. LINC01089 competitively binds to miR-145-5p to mediate SOX9 expression. Yes LINC01089 overexpression notably expedited cell migration, proliferation, and invasion. 32982308 LINC01089 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells interaction[sponging miR-3187-3p] qRT-PCR//Transwell Assay LINC01089 expression was significantly reduced in NSCLC tissues and cells. LINC01089 attenuates tumor proliferation, migration, and invasion by sponging miR-3187-3p in NSCLC. Yes Gain-of-function studies further demonstrated that LINC01089 overexpression inhibited proliferation, migration, and invasion of lung cancer cell lines, A549 and SK-MES-1. 33269007 LINC01089 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Interaction(miR-301b-3p/HPDG axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//ChIP Our data revealed that LINC01089, directly suppressed by YY1, inhibited lung cancer progression by targeting the miR-301b-3p/HPGD axis. LINC01089, directly suppressed by YY1, functioned as a competing endogenous RNA against miR-301b-3p to increase HPGD expression. Graphical abstract 1. LINC01089 expression was downregulated in lung cancer tisuues and cell lines, and low LINC01089 levels predicted a poor clinical outcome. Yes LINC01089 knockdown enhanced proliferation, invasion, and migration of H1299 and A549 cells in vitro and promoted lung cancer cell tumorigenesis and metastasis in vivo. 34561789 LINC01089 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue and cell lines. Expression(lower expressed) qRT-PCR LIMT expression was significantly lower in HCC than in normal liver tissue. Yes Functionally, overexpression of LIMT repressed the proliferation, invasion, and EMT of HCC cells, while LIMT knockdown increased proliferation, invasion, and EMT of HCC cells in vitro.Furthermore, LIMT overexpression suppressed HCC growth and metastasis while silencing of LIMT had an opposite effect in vivo. 35526240 LINC01089 LncRNA Homo sapiens Osteosarcoma osteosarcoma cells Regulation(Hippo pathway ) qRT-PCR LINC01089 was down-regulated in osteosarcoma cells and overexpressing LINC01089 was validated to restrain cell growth in vitro and tumor growth in vivo. Additionally, silencing LINC01089 could exacerbate cell malignant behaviors. Correlation of LINC01089 and Hippo pathway was proved. Overexpressing LINC01089 could activate Hippo pathway to exert antitumor effects. Yes LINC01089 was down-regulated in osteosarcoma cells and overexpressing LINC01089 was validated to restrain cell growth in vitro and tumor growth in vivo. 36399257 LINC01089 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells and tissues regulation[inhibiting miR-27a-3p and increasing BTG2] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//BrdU//Transwell Assay The expression of LINC01089 in CC was markedly down-regulated. LINC01089, as a tumor suppressor, impedes the development of CC by targeting miR-27a-3p to up-regulate BTG2 expression. The low expression of LINC01089 in CC was closely associated with a larger tumor size and positive lymph node metastasis. Yes Moreover, overexpression of LINC01089 impeded the proliferation and metastasis of CC cells, whereas knockdown of LINC01089 had the opposite biological functions. 33025678 LINC01089 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues and cells Interaction(miR-27b-3p/FBLN5) Western Blot//Bioinformatics Analysis//Transfection//qRT-PCR//Luciferase Report Assay//Invasion Assay Here, The Cancer Genome Atlas (TCGA) database showed that LINC01089 expression is remarkably reduced in thyroid cancer tissues. In conclusion, LINC01089 plays a tumor-suppressive role by binding miR-27b-3p to increase FBLN5 expression, confirming that LINC01089 has tremendous potential to become a therapeutic target for thyroid cancer treatment. Lower LINC01089 expression was correlated with higher tumor stage and regional lymph node metastasis. Yes Furthermore, LINC01089 overexpression effectively blocked thyroid cancer cell proliferation, migration, and invasion. 36306007 LINC01089 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD Interaction(miR-543/ Bcl-2, Bax and Cleaved caspase-3) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay LINC01089 improved overall survival of LUAD patients and was low-expressed in LUAD. MiR-543 was determined as a target gene of LINC01089, and was high-expressed in LUAD tissues. Upregulating miR-543 expression induced the opposite effects to LINC01089 upregulation on these cellular biological behaviors and the expressions of Bcl-2, Bax and Cleaved caspase-3. Yes Upregulating LINC01089 expression reduced LUAD cell viability, inhibited colony formation, enhanced apoptosis, accompanied by downregulated Bcl-2 and miR-543 and upregulated Bax and Cleaved caspase-3. 33892399 LINC01088 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction(miR-95/LATS2) Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay LINC01088 and LATS2 mRNA expression decreased, and miR-95 increased in gastric cancer tissues. LINC01088 has an excellent positive correlation with LATS2 mRNA, which may be a ceRNA pair; LINC01088 has binding sites with miR-95. Yes Gene interference tests on gastric cancer cell lines revealed that LINC01088 could prevent gastric cancer cells from proliferating, invading, and migrating. The function of LINC01088 is achieved by regulating the miR-95/LATS2 pathway through the ceRNA mechanism. 35728587 LINC01088 LncRNA Homo sapiens Glioma glioma cell Interaction(SNRPA ) RNA Pull-Down//Transfection//qRT-PCR//RIP//Transwell Assay Mechanistically, we verified LINC01088 physically interacted with small nuclear ribonucleoprotein polypeptide A (SNRPA) and regulated the expression of SNRPA at the transcription level. Phenotypic analysis ascertained that LINC01088 substantively aggravated glioma cell progression in an SNRPA-dependent manner, and SNRPA played a pivotal part in the tumor-promoting properties of LINC01088. Yes Functionally, LINC01088 silencing degraded cell proliferation, invasion in glioma, while LINC01088 overexpression elicited opposite results. 35392763 LINC01088 LncRNA Mus musculus Colorectal Neoplasms colorectal cancer tissues and CRC cell lines Regulation(microRNAs/G3BP1/PD-L1 axis) CCK8//qRT-PCR//RIP We found that LINC01088 was significantly upregulated in colorectal cancer tissues and CRC cell lines compared to adjacent normal tissues and colonic epithelial cells. High LINC01088 levels were correlated with adverse outcomes in patients with CRC. LINC01088 was mainly located in the cytoplasm. LINC01088 knockdown suppressed the proliferation, migration, invasion, and immune escape of colorectal cancer cells. Mechanistically, LINC01088 bound directly to miR-548b-5p and miR-548c-5p that were significantly upregulated Ras GTPase-activating protein-binding proteins 1 (G3BP1) and programmed death ligand 1 (PD-L1) expression, altering CRC cell phenotypes. In mouse xenograft models, LINC01088 knockdown restrained CRC tumor growth and lung metastasis. Furthermore, G3BP1 overexpression reversed LINC01088-knockdown-mediated inhibitory effects on tumor growth. Notably, LINC01088 knockdown downregulated PD-L1 expression, while G3BP1 overexpression restored PD-L1 expression in xenograft tumors. Besides, LINC01088 knockdown repressed CRC organoid growth ex vivo. High LINC01088 levels were correlated with adverse outcomes in patients with CRC. Yes LINC01088 knockdown suppressed the proliferation, migration, invasion, and immune escape of colorectal cancer cells. Mechanistically, LINC01088 bound directly to miR-548b-5p and miR-548c-5p that were significantly upregulated Ras GTPase-activating protein-binding proteins 1 (G3BP1) and programmed death ligand 1 (PD-L1) expression, altering CRC cell phenotypes. In mouse xenograft models, LINC01088 knockdown restrained CRC tumor growth and lung metastasis. Furthermore, G3BP1 overexpression reversed LINC01088-knockdown-mediated inhibitory effects on tumor growth. Notably, LINC01088 knockdown downregulated PD-L1 expression, while G3BP1 overexpression restored PD-L1 expression in xenograft tumors. Besides, LINC01088 knockdown repressed CRC organoid growth ex vivo. 35357586 LINC01087 LncRNA Homo sapiens Breast Neoplasms BC tissues regulation[miR-335-5p/Rock1] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay The qRT-PCR assay revealed that the LINC01087 expression in BC tissues was higher than that in corresponding tumor-adjacent tissues, and survival analysis revealed an unfavorable prognosis of patients with high expression of LINC01087. Furthermore, LINC01087 can act as a miR-335-5p sponge to affect the expression of ROCK1 and affect the invasion and migration of BCCs. The qRT-PCR assay revealed that the LINC01087 expression in BC tissues was higher than that in corresponding tumor-adjacent tissues, and survival analysis revealed an unfavorable prognosis of patients with high expression of LINC01087. Yes Down-regulation of LINC01087 could slow down the proliferation, invasion, and migration of BCCs and accelerate apoptosis of them in vitro. 33061456 LINC01082 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Expression[lower expressed] CCK8//qRT-PCR//Transwell Assay The results revealed that LINC01082 was significantly decreased in tissues and cell lines of colon cancer. Yes Overexpressed LINC01082 significantly suppressed the proliferation ability of colon cancer cells. The migration and invasion of colon cancer cells were also suppressed after LINC01082 overexpression. 31432387 LINC01061 LncRNA Homo sapiens Cholangiocarcinoma cell lines Interaction[sponges miR-612] qPCR//CCK8//RIP//FISH//Luciferase Report Assay//Transwell Assay Firstly, it was observed that LINC01061 expression was heightened in CCA cell lines, whose knockdown suppressed cell proliferation, induced cell apoptosis and restrained cell migration.To sum up, our present exploration demonstrated that LINC01061 sponges miR-612 so as to upregulate SEMA4D expression for the progression of CCA, suggesting an optional promising and effective target for the therapy of patients with CCA. Yes Firstly, it was observed that LINC01061 expression was heightened in CCA cell lines, whose knockdown suppressed cell proliferation, induced cell apoptosis and restrained cell migration. 30967271 LINC00974 LncRNA Homo sapiens Oral Submucous Fibrosis OSF tissues Regulation[TGF-β/Smad signaling] qRT-PCR//Wound Healing Assay We found that the expression of LINC00974 in OSF tissues or myofibroblasts was aberrantly upregulated, and there was a positive correlation between LINC00974 and myofibroblast markers. Altogether, these findings suggested that arecoline-increased myofibroblast transdifferentiation was via LINC00974-mediated activation of TGF-β signaling. Yes Our results showed that inhibition of LINC00974 suppressed the myofibroblast activities, while overexpression of LINC00974 increased the activation. 30447113 LINC00968 LncRNA Homo sapiens Coronary Artery Disease CAD tissues Regulation[regulating miR-9-3p ] qRT-PCR We showed that the LINC00968 expression level was upregulated in the CAD tissues compared with normal arterial tissues.Finally, we showed that ectopic expression of LINC00968 promoted endothelial cell proliferation and migration partly through regulating miR-9-3p expression. These results suggested that LINC00968 plays a crucial role in the progression of the CAD. Yes Ectopic expression of LINC00968 regulated the proliferation and migration of endothelial cell. 30485507 LINC00963 LncRNA Homo sapiens Stomach Neoplasms GC tissues interaction[ binding to miR-612] qRT-PCR//Transwell Assay LINC00963 expression was higher in GC tissues than in adjacent normal tissues. LINC00963 promoted the progression of GC by competitively binding to miR-612 to regulate the expression of CDC5L and mediated DC-related anti-tumor immune response. Thus, targeting LINC00963 may be a promising therapeutic strategy for GC. Yes Upregulation of LINC00963 was related to the poor prognosis of patients with GC. Knockdown of LINC00963 inhibited the proliferation, invasion, and metastasis but promoted the apoptosis of GC cells. Furthermore, silencing of LINC00963 in GC cells significantly suppressed the tumor growth of GC. 33376349 LINC00958 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissue and cell lines Regulation[LINC00958/miR-185-5p/YWHAZ regulatory axis] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay LINC00958 expression was remarkably up-regulated in the OSCC tissue and cell lines.Taken together, the findings in this research reveal the modulation of LINC00958 for the OSCC tumorigenesis through the miR-185-5p/YWHAZ axis, which might be useful for the mechanical investigation associated with OSCC therapeutic target. Clinical investigation showed that LINC00958 overexpression was associated with poor prognosis, acting as an independent prognostic factor for OSCC. Yes Loss- and gain-of-function assays indicated that LINC00958 promoted the proliferation, invasion and reduced the apoptosis of OSCC cells in vitro. In vivo, knockdown of LINC00958 repressed the tumor growth. 31442551 LINC00958 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells Interaction( miR-4306/AIM2/SIRT/p53 ) CCK8//qRT-PCR//RIP We found that LINC00958 showed upregulation in OSCC cells compared to normal oral epithelial cells. Yes LINC00958 silencing significantly suppressed OSCC cell proliferation, induced cell death and reduced autophagy. 34384029 LINC00958 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Interaction(miR-4306/CEMIP axis) qRT-PCR//Luciferase Report Assay LINC00958 expression levels significantly increased in osteosarcoma tissues while miR-4306 expression levels significantly decreased, and the expression of these two genes was negatively correlated. Subcellular fractionation analysis and RNA FISH assay demonstrated that LINC00958 was mainly localized in the cytoplasm. Dual-luciferase reporter gene assay verified that LINC00958 competitively bound miR-4306 and repressed its expression. Silencing of LINC00958 inhibited proliferation, cell cycle, metastasis, and invasion of osteosarcoma cells while inducing cellular apoptosis. The introduction of miR-4306 inhibitors reversed the tumor-suppressing effect of silencing LINC00958. miR-4306 binds to CEMIP and suppressed its expression. Xenograft tumor experiments and tumor metastasis assays in nude mice demonstrated that silencing LINC00958 inhibited osteosarcoma cells' growth and metastasis while inhibiting miR-4306 reversed this effect. Kaplan-Meier analysis showed that high expression of LINC00958 was significantly associated with poor prognosis of osteosarcoma patients. Kaplan-Meier analysis showed that high expression of LINC00958 was significantly associated with poor prognosis of osteosarcoma patients. Yes Dual-luciferase reporter gene assay verified that LINC00958 competitively bound miR-4306 and repressed its expression. Silencing of LINC00958 inhibited proliferation, cell cycle, metastasis, and invasion of osteosarcoma cells while inducing cellular apoptosis. The introduction of miR-4306 inhibitors reversed the tumor-suppressing effect of silencing LINC00958. 33928604 LINC00958 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissue Regulation[LINC00958-miR-625-NUAK1 pathway ] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay LINC00958 was found to be upregulated in NPC tissue specimens and cell lines. The LINC00958-miR-625-NUAK1 pathway might be a target for anticancer therapy in patients with NPC. The LINC00958 overexpression significantly correlated with tumor size, lymph node status, TNM stage, and worse overall survival among NPC patients. Yes Downregulation of LINC00958 suppressed NPC cell proliferation, migration, and invasion and induced apoptosis in vitro. Additionally, the LINC00958 knockdown impaired tumor growth in vivo. 31819474 LINC00958 LncRNA Homo sapiens Adenocarcinoma of Lung tissue samples of LAD regulation[miR-625-5p/CPSF7 axis] RNA Pull-Down//Western Blot//Tunel//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay LINC00958 was found notably overexpressed in LAD, which was associated with the stimulation of its promoter activity induced by SP1. LINC00958 might drive LAD progression via mediating miR-625-5p/CPSF7 axis, indicating the potential of targeting LINC00958 for the treatment of LAD. Yes LINC00958 depletion dramatically inhibited LAD cell proliferation, migration and invasion capacities by acting as a miR-625-5p sponge. 31997940 LINC00958 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues, lung cancer cells Expression(highly expressed) RNA Pull-Down//CCK8//qRT-PCR//FISH//RNA-seq//Luciferase Report Assay//IHC//Bioinformatics Analysis The expression of LINC00958 in LUAD tissues was significantly upregulated when compared with that in adjacent tissues and could independently predict poor survival of patients with LUAD. LINC00958 localized to the nucleus, regulated oncogenes and metabolism-related and immune response-related genes, and interacted with histones. The targets of LINC00958 were TRPV3, STAP2, and EDN2 promoters with motifs of HOXA1, NANOG, FOSL2, JUN, and ATF4. Moreover, HOXA1 overexpression mitigated the LINC00958 knockdown-induced oncogenic phenotype. MYC/MAX motif, which was detected at the cis-element of LINC00958, trans-activated the LINC00958 promoter. The expression of LINC00958 in LUAD tissues was significantly upregulated when compared with that in adjacent tissues and could independently predict poor survival of patients with LUAD. Yes LINC00958 knockdown significantly inhibited the growth and metastasis of lung cancer cells in vitro and in vivo. 35223488 LINC00958 LncRNA Homo sapiens Endometrial Neoplasms EC tissues Interaction(miR-145-3p/TCF4 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay LINC00958 was remarkably upmodulated in EC. LINC00958 was validated to decoy miR-145-3p and repressed its expression, and TCF4 was uncovered to be a target gene of miR-145-3p and negatively modulated by miR-145-3p. Moreover, its overexpression was strongly linked to unfavorable overall survival of the patients. Yes Functional experiments confirmed that in vitro knockdown of LINC00958 suppressed EC cell proliferation and metastasis. 33885186 LINC00958 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(LINC00958/miR-627 signal axis) cell invasion assay//Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay Long noncoding RNA ENST00000504230 (LncRNA ENST00000504230, known as LINC00958) was overexpressed in many cancers and associated with cancer development. LINC00958 was up-regulated in PTC tissues and cells, while the expression of miR-627 was lowly expressed. TRIM44 was confirmed as a target of miR-627. Overexpression of miR-627 in PTC inhibited the proliferation, migration, and invasion by down-regulating the expression of TRIM44. Yes Knockdown of LINC00958 inhibited the proliferation, migration, and invasion by elevating miR-627 expression in PTC cells. T 35199939 LINC00944 LncRNA Homo sapiens Carcinoma, Renal Cell renal cell carcinoma (RCC) tissues and cell lines Expression [highly expressed] qRT-PCR In our study, we identified the expression of lncRNA LINC00944 is significantly elevated in renal cell carcinoma (RCC) tissues and cell lines and high LINC00944 expression is significantly correlated with the tumor stage and prognosis of RCC. high LINC00944 expression is significantly correlated with the tumor stage and prognosis of RCC. Yes The knockdown of LINC00944 by CRISPR/dCas9-KRAB in higher expressing 786-O and 769-P RCC cells could significantly decrease proliferation and migration and also promote phosphorylation of Akt compared with the control group. 34291088 LINC00943 LncRNA Mus musculus Parkinson Disease SK-N-SH cell, brain tissues Interaction(miR-338-3p/SP1 axis) qRT-PCR//Western Blot Our data showed that LINC00943 was highly expressed in the brain tissues of MPTP-treated mice and MPP+-induced SK-N-SH cells. In terms of mechanism, we pointed out that LINC00943 could sponge miR-338-3p, and miR-338-3p could target SP1. The negative regulation of si-LINC00943 on MPP+-induced SK-N-SH cell injury could be reversed by miR-338-3p inhibitor. Moreover, miR-338-3p had a protective effect on SK-N-SH cells from MPP+-induced injury, which could be reversed by SP1 overexpression. Additionally, we confirmed that LINC00943 positively regulated SP1 via sponging miR-338-3p. Yes Knockdown of LINC00943 could promote the proliferation, while inhibit the apoptosis and inflammation of MPP+-induced SK-N-SH cells to alleviate cell injury. 35123924 LINC00942 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction(miR-5006-5p/FZD1) Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay We discovered that LINC00942 was up-regulated in LUAD tissues compared with adjacent tissues. Mechanically, LINC00942 exerted its effects via enhancing Wnt signaling. LINC00942 functioned as competing endogenous RNA (ceRNA) by binding to miR-5006-5p, upregulating the expression of FZD1, which was a direct target of miR-5006-5p. Besides, we found the increased LINC00942 expression was associated with poor survival. Yes In addition, silencing of LINC00942 suppressed the proliferation, migration, invasion and facilitated the apoptosis of A549 and H1299 cells. Moreover, silencing of LINC00942 repressed the expression of PCNA, Bcl-2, and enhanced Bax expression in A549 and H1299 cells. 34253104 LINC00941 LncRNA Homo sapiens Stomach Neoplasms Regulated[up-regulated] Western Blot//Migration Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay Our findings confirmed that LINC00941 plays an important oncogenic function in GC and may serve as a potential biomarker for diagnosis and prognosis of GC. Yes To validate our findings, we utilized the loss-of-function analysis to reveal the biological function of LINC00941 in GC cells. Loss-of-function analysis revealed that silence of LINC00941 inhibits GC cells proliferation, migration, and invasion in vitro and modulates tumor growth in vivo. 30723491 LINC00941 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues and cells Interaction(miR-205-5p/MYC axis) CCK8//qRT-PCR//RIP//Western Blot LINC00941 expression level was elevated in colon cancer tissues and cells. In addition, LINC00941 regulated the expression of MYC by sponging miR-205-5p as a competitive endogenous RNA, and miR-205-5p knockdown reversed the tumor inhibition of LINC00941 knockdown on colon cancer cells. Yes LINC00941 overexpression accelerated proliferation, migration, and invasion of colon cancer cells, while the LINC00941 knockdown showed the opposite results. Xenograft model assay confirmed that LINC00941 silencing could inhibit colon cancer cell growth and metastasis. 33654409 LINC00941 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cell lines and tumour tissues regulation[WNT/β-catenin signaling pathway] qRT-PCR//Northern Blot//Luciferase Report Assay//Colony Formation Assay Thus, LINC00941/CAPRIN2/ WNT/β-catenin signaling pathway provides new therapeutic targets for OSCC treatment. Yes Functional assays suggest that both LINC00941 and CAPRIN2 play pivotal roles in promoting OSCC cell proliferation and colony formation. In vivo assay further confirmed the role of LINC00941 in promoting OSCC cell tumour formation. 32691935 LINC00941 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(hnRNPK) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In this study, we report a never identified before lncRNA, LINC00941, which was highly expressed in OSCC tissues and cells. In silico analyses revealed heterogeneous nuclear ribonucleoprotein K (hnRNPK) to be a strong positive regulator of LINC00941 activity. Experimental verification of this association revealed a direct interaction of LINC00941 and hnRNPK to induce cell growth and invasion by activating EMT in OSCC cells. Yes Expression of LINC00941 promoted cell proliferation, migration, invasion, and metastasis of OSCC cells In Vitro by inducing epithelial-mesenchymal transition (EMT) and activating the Wnt/β-catenin signaling cascade. 35037538 LINC00941 LncRNA Homo sapiens Glioma all glioma subtypes Expression(highly expressed) Western Blot//CCK8//qRT-PCR//Cell Apoptosis Assay//Invasion Assay//Transwell Assay Here, we reported that lncRNA-LINC00941 was highly expressed in all glioma subtypes. Yes Overexpression of lncRNA-LINC00941 in U87 cells promoted cellular proliferation and invasiveness, and suppressed apoptosis. 36375627 LINC00941 LncRNA Homo sapiens Pancreatic Neoplasms PDAC patients Interaction(MST1/PP2A) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//ISH//qRT-PCR//RIP//Colony Formation Assay//IF By analyzing a long noncoding RNA (lncRNA) dataset, we found that increased LINC00941 expression led to poor outcomes in PDAC patients. Mechanistically, LINC00941 was found to interact with mammalian STE20-like protein kinase 1 (MST1), which facilitated the protein phosphatase 2A (PP2A)-mediated dephosphorylation of MST1, resulting in Hippo pathway activation and consequently, enhanced glycolysis in PDAC. By analyzing a long noncoding RNA (lncRNA) dataset, we found that increased LINC00941 expression led to poor outcomes in PDAC patients. Yes Furthermore, in vitro and in vivo experiments revealed that LINC00941 promoted PDAC cancer cell growth by enhancing aerobic glycolysis. 34513310 LINC00941 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues Interaction(ANXA2/NEDD4L) In Vivo Experiment//RNA Pull-Down//Western Blot//Bioinformatics Analysis//Co-IP//Migration Assay//qRT-PCR//RIP//Cell Proliferation Assay//Invasion Assay//IF By using PCR analysis, we found that LINC00941 was overexpressed in PC tissues and was higher in patients with liver metastasis than in patients without liver metastasis. Mechanically, LINC00941 functioned as a decoy to bind to ANXA2 and suppressed its degradation by enclosing the domain that binds to NEDD4L. Eventually, LINC00941 upregulated ANXA2 and activated FAK/AKT signaling, increasing PC cell proliferation and metastasis. In addition, high LINC00941 expression was associated with a poor prognosis. Yes The results suggested that LINC00941 overexpression promoted PC proliferation and metastasis. 35977942 LINC00958 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation(NUDT19/mTORC1/P70S6K signalling pathway) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP The LINC00958 was up-regulated in HCC tissues and cell lines. The analysis of TCGA and StarBase showed that NUDT19 was a direct target of LINC00958 and was positively regulated by LINC00958. Besides, NUDT19 activated mTORC1/P70S6K signalling pathway. Yes LINC00958 silencing inhibited cell proliferation, migration, and EMT process of HCC. 33979257 LINC00958 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Expression[highly expressed] qRT-PCR//Luciferase Report Assay//RIP//FISH We identified a lipogenesis-related lncRNA, LINC00958, whose expression was upregulated in HCC cell lines and tissues. High LINC00958 level independently predicted poor overall survival. Yes Functional assays showed that LINC00958 aggravated HCC malignant phenotypes in vitro and in vivo. 31915027 LINC00958 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues and cell lines Regulation(Wnt/ β-Catenin Signaling) qRT-PCR//Luciferase Report Assay Higher levels of LINC00958 were observed in EOC tissues and cell lines.Our data also revealed that high LINC00958 expression was partly induced by STAT1. Mechanistic investigation showed that the inhibitory effect of LINC00958 knockdown on EOC cells was mediated by the Wnt/β-catenin signaling. Yes Functionally, knockdown of LINC00958 suppressed the proliferation, migration, and invasion of EOC cells. 34790276 LINC00963 LncRNA Homo sapiens Prostatic Neoplasms CRPC tissues regulation[ miR-542-3p,NOP2] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//RNA-seq//Transwell Assay Recent studies have revealed that non-coding RNAs in PCa can enhance metastasis and progression, while the mechanisms are still unclear. In this study, we reported that the long noncoding RNA-LINC00963 was increased in CRPC tissues and promoted migration of PCa cells in vitro and their metastasis in vivo. Taken together, our results show that LINC00963 acts as an inducer of PCa metastasis by binding miR-542-3p, thereby promoting NOP2. Yes Recent studies have revealed that non-coding RNAs in PCa can enhance metastasis and progression, while the mechanisms are still unclear. In this study, we reported that the long noncoding RNA-LINC00963 was increased in CRPC tissues and promoted migration of PCa cells in vitro and their metastasis in vivo. 32554858 LINC00963 LncRNA Homo sapiens Breast Neoplasms breast cancer cells Interaction(miR-34c/LINC00963 target) Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay The long non-coding RNA LINC00963 was found to have a significantly high expression level in breast cancer while it can be down-regulated by corylin. MiR-34c was increased by corylin treatment depending on p53, and it was firstly identified that the LINC00963 was a direct target of miR-34c. Corylin was verified here that it prohibited MCF-7 migration and invasion depending on miR-34c/LINC00963 target. In conclusion, corylin suppresses metastasis of breast cancer cells via increasing miR-34c expression, which was dependent on p53. LINC00963 was a direct target of miR-34c and the target axis was necessary for corylin function. Yes In addition, both wound-healing assay and transwell assay showed that LINC00963 induced breast cancer cells metastasis. 33550958 LINC00963 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR‑1281 and TRIM65) CCK8//qRT-PCR//Western Blot LINC00963 was highly expressed in CRC tissues and cells, while miR?1281 was downregulated. Mechanistically, LINC00963 sponged miR‑1281 and repressed its expression in CRC cells, resulting in the upregulation of TRIM65. LINC00963 positively regulates TRIM65 in CRC progression by repressing miR‑1281 expression, showing potential as a therapeutic target for treating CRC. Yes Functionally, LINC00963 facilitated the proliferation, colony formation, migration and invasion of CRC cells, and increased the expression levels of Ki67, matrix metalloproteinase (MMP)2 and MMP9, while miR?1281 had the opposite biological functions. 34498706 LINC00963 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR‑10b/FGF13 axis) qRT-PCR//Wound Healing Assay//Western Blot Firstly, the LINC00963 expression was detected using reverse transcription‑quantitative PCR and the results demonstrated that LINC00963 expression levels were significantly increased in CRC tissues and cell lines compared with healthy tissues and HpoEpiC cells, respectively. Collectively, the results of the present study suggested a potential role of the LINC00963/miR-10b/FGF13 axis in the tumorigenesis and progression of CRC, indicating a novel lncRNA-based diagnostic or therapeutic target for CRC. Online database analysis indicated that high levels of LINC00963 were associated with low survival rates. Yes The results of functional experiments, such as CCK‑8 assay, colony formation assay, wound healing assay and Transwell invasion assay, indicated that LINC00963 knockdown significantly inhibited CRC cell proliferation, colony formation, migration and invasion compared with the small interfering RNA (si)‑negative control (NC) group. 33495804 LINC00963 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Regulation [PI3K/AKT pathway] qRT-PCR The expression level of LINC00963 in HCC tissues was remarkably higher than that in paracancerous tissues, indicating a potential diagnostic significance of LINC00963. Furthermore, the PI3K/AKT expression was increased after overexpression of LINC00963, while AKT siRNA effectively reversed the prolonged G0/G1 phase caused by LINC00963 overexpression. The expression level of LINC00963 in HCC tissues was remarkably higher than that in paracancerous tissues, indicating a potential diagnostic significance of LINC00963. The progression-free -with the tumor size and TNM stage, but not with age, gender, histological type and lymph node metastasis. Yes Overexpression of LINC00963 significantly enhanced the proliferation ability of HepG2 and HCC cells and prolonged their G0/G1 phase. 29630107 LINC00963 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues regulation[miR-378g / CHI3L1 Axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//EdU Staining//Transwell Assay In our study, the GSE119054 microarray was analyzed, and LINC00963 showed a significant higher level in ovarian cancer tissues compared with controls.In addition, results show that LINC00963 is a cytoplasmic lncRNA that shares the miRNA response elements (MREs) of miR-378g with CHI3L1, which is confirmed by a luciferase reporter assay and AGO2-dependent RNA immunoprecipitation (RIP). It was discovered that LINC00963 displayed a close relationship with unfavorable prognosis, and it was prominently raised in OC tissues of patients with lymph node metastasis. Yes What's more, LINC00963 downregulation in OC cells inhibited cell migration and invasion and inverted EMT triggered by TGF-β1. LINC00963 downregulation also inhibited tumorigenesis in nude mice. 32021459 LINC00963 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Regulation[miR-204-3p/FN1 axis] Western Blot//Wound Healing Assay//CCK8//Luciferase Report Assay//PCR//Transwell Assay LINC00963 was verified to be highly expressed in OS samples and cells. The luciferase reporter assay showed that LINC00963 can suppress miR-204-3p by directly binding miR-204-3p. Rescue experiment results indicated that function of LINC00963 in osteosarcoma was miR-204-3p dependant. Besides, we initially explored Fibronectin-1 (FN1) as the target of LINC00963/miR-204-3p axis in osteosarcoma. Yes Furthermore, LINC00963 overexpression was found to promote proliferation, migration, and invasion in vitro. 30975024 LINC00963 LncRNA Homo sapiens Esophageal Neoplasms ESCC tissues regulation[miR-214-5p/RAB14 axis] qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay LINC00963 expression was significantly increased in ESCC tissues and correlated with advanced TNM stage, metastasis, and poor prognosis. LINC00963 might promote ESCC cells proliferation and invasion via regulating the miR-214-5p/RAB14 axis and it might serve as a therapeutic target for ESCC treatment. LINC00963 expression was significantly increased in ESCC tissues and correlated with advanced TNM stage, metastasis, and poor prognosis. Yes The knockdown of LINC00963 expression reduced ESCC cells proliferation, invasion in vitro, and reduced tumor growth in vivo. 31957829 LINC00963 LncRNA Homo sapiens Glioma glioma cells and tissues regulation[miR-506/BCAT1 Axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay We found that LINC00963 was upregulated in glioma cells and tissues and associated with the poor prognosis of patients with glioma.Our data revealed that LINC00963 confers oncogenic function in the progression of glioma and that the LINC00963/miR-506/BCAT1 axis may be a novel mechanism and therapeutic strategy for this disease. Yes Ectopic expression of LINC00963 promoted cell proliferation, cell cycle progression, migration, and invasion in vitro and tumorigenesis in vivo. 32273770 LINC00963 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[miR-124-3p/FZD4 pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, LINC00963 was significantly upregulated in CRC tissues and cells.Our study demonstrated that LINC00963/miR-124-3p/FZD4 played a curial role in cell proliferation and migration in CRC. Yes Functionally, LINC00963 knockdown inhibited cell progression in CRC. 32744689 LINC00958 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cell lines Interaction(miR-3064-5p/LEMD1/PI3K/AKT pathway) BrdU//qRT-PCR//RIP//Western Blot LINC00958 and LEMD1 were found to have increased, while the expression of miR-3064-5p was decreased in colorectal cancer tissues and cell lines. Notably, LINC00958 inhibited miR-3064-5p and promoted LEMD1; the miR-3064-5p inhibitor abrogated the effect of LINC00958 silencing in colorectal cancer cells. Additionally, LEMD1 knockdown inhibited the activation of PI3K/AKT signaling. Yes Silencing of LINC00958 hampered cell viability, proliferation, migration, and invasion, while enhancing the apoptosis in colorectal cancer cells. 34672237 LINC00963 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse SUDHL4 cell line Interaction(miR-320a/XBP1) In Vivo Experiment//Western Blot//qPCR//CCK8//Flow Cytometry//Luciferase Report Assay//IHC//IF Following LINC00963 overexpression in vitro, SUDHL4 cell line showed a marked increase in the level of UPR-related GRP78, p-IRE1 and spliced XBP-1/XBP-1(s), apoptosis-related Bax and cleaved caspase 3, as well as autophagy-related Beclin1 and LC3II, whereas miR-320a mimic greatly diminished the effects of LINC00963 overexpression. Moreover, LINC00963 targeted miR-320a while miR-320a bound to the 3'UTR of XBP1. Yes It was also found that LINC00963 overexpression resulted in significantly delayed tumor growth in a xenograft model of DLBCL. 34112145 LINC00963 LncRNA Homo sapiens Pulmonary Arterial Hypertension PASMCs and PAH mouse model Interaction(microRNA-328-3p/profilin 1 axis) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//H&E Staining//Transwell Assay In hypoxia-induced PASMCs and PAH mouse model, high expression levels of LINC00963 and PFN1, and low expression of miR-328-3p, were determined. The inhibitory effects of LINC00963 silencing on cell viability, migration, and the levels of VEGF, FGF-2, and HIF-α were partly eliminated by miR-328-3p inhibitor or increasing the expression of PFN1. Hypoxia treatment increased the levels of RVSP, mPAP, and RV/(LV+S), as well as the thickness of pulmonary artery wall. Yes The viability, migration of hypoxia-induced PASMCs, the expression of VEGF, FGF-2, and HIF-α were significantly repressed by transfection of si-LINC00963 or miR-328-3p mimics. 35349725 LINC00960 LncRNA Homo sapiens Osteosarcoma osteosarcoma cells Interaction(miR-107/SALL4 ) qRT-PCR//Western Blot Further investigation revealed that LINC00960 could regulate SALL4 by sponging miR-107 to promote the progression of OS. Yes In vitro study showed that silencing LINC00960 inhibited proliferation, migration and invasion of 143B and MG63. In vivo study demonstrated that knockdown of LINC00960 repressed tumor growth. 35033873 LINC00960 LncRNA Homo sapiens Adenocarcinoma of Lung LADC tumor tissues and cell lines Interaction(miR-124a/SphK1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//ELISA//Colony Formation Assay//Transwell Assay We observed that LINC00960 was overexpressed in LADC tumor tissues and cell lines.Moreover, LINC00960 sponged miR-124a to inhibit the SphK1/S1P pathway in LADC cells. The luciferase reporter assay results demonstrated an interaction between miR-124a and LINC00960 or SphK1. This interaction was confirmed using the RNA pull-down assay. In addition, miR-124a downregulation or SphK1 upregulation reversed the inhibitory effects of LINC00960 knockdown on cellular functions of LADC cells, suggesting that LINC00960 may be a potential therapeutic biomarker for LADC via the miR-124a/SphK1 axis. Yes LINC00960 knockdown suppressed the proliferation, migration, and invasion of LADC cells. LINC00960 knockdown markedly reduced the rate of tumor growth. 34738865 LINC00958 LncRNA Homo sapiens Stomach Neoplasms GC tissue and cell Regulation(GLUT1 ) In Vivo Experiment//qRT-PCR//MeRIP-seq//Western Blot Here, our team discovered that lncRNA LINC00958 expression up-regulated in GC tissue and cells. Mechanistically, methylated RNA immunoprecipitation sequencing (MeRIP-Seq) found that there were m6 A-modificated sites in LINC00958, and moreover m6 A methyltransferase KIAA1429 catalyzed the m6 A modification on LINC00958 loci. Moreover, LINC00958 interacted with GLUT1 mRNA via the m6 A-dependent manner to enhance GLUT1 mRNA transcript stability, thereby positively regulating the aerobic glycolysis of GC. Clinically, high-expression of LINC00958 was clinically correlated to lower survival of GC patients. Yes Functionally, in vitro assays demonstrated that LINC00958 promoted the GC cells' aerobic glycolysis. 34409730 LINC00958 LncRNA Homo sapiens Breast Neoplasms BC tissue and cells Interaction(miR-378a-3p/YY1 axis) CCK8//qRT-PCR//Flow Cytometry we also detected the levels of LINC00958 in BC cell lines and found that LINC00958 was markedly upregulated compared to that in normal cells the lncRNA LINC00958 indicated an unfavorable prognosis for patients with BC. Yes Functional assays found that LINC00958 upregulation regulated the proliferation and apoptosis of BC cells. 33531456 LINC00958 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Regulation[JNK/c-JUN Signaling] Western Blot//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay First of all, the online databases suggested that LINC00958 was slightly expressed in human normal lung tissues but upregulated in LUSC tissues.By and large, our work illustrated that LINC00958 facilitates tumorigenesis in NSCLC by activating the JNK/c-JUN signaling pathway, indicating a new road for diagnosis and treatment of both LUAD and LUSC. Yes In addition, we elucidated that knockdown of LINC00958 led to impaired proliferation, induced apoptosis, and hampered migration in LUAD cells. 31855084 LINC00958 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(MiR-204-3p/KIF2A Axis) qRT-PCR//Luciferase Report Assay//IHC//Western Blot We found that LINC00958 was up-regulated in NSCLC tissues and cell lines. Besides, miR-204-3p was identified as a target of LINC00958 and miR-204-3p inhibitor could reverse the inhibitory effect of LINC00958 knockdown on proliferation and migration of NSCLC cells. We also validated that KIF2A, a direct target of miR-204-3p, was responsible for the biological role of LINC00958. KIF2A antagonized the effect of miR-204-3p on NSCLC cell proliferation and migration and was regulated by LINC00958/miR-204-3p. Yes Down-regulation of LINC00958 inhibited cell proliferation and migration in vitro and suppressed tumor growth in vivo. 34269081 LINC01106 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and cells regulation[miR-449a/MET Axis] Western Blot//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay LncRNA LINC01106 expression was highly up-regulated in EC tissues and cells.Silencing of LINC01106 inhibits the occurrence and development of EC via regulating the miR-449a/MET axis. Yes The proliferation, migration and invasion of EC cells in vitro were inhibited by the transfection of sh-LINC01106. The growth of tumor xenograft was suppressed by injection of sh-LINC01106. 33061446 LINC01111 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues,blood Regulation[LINC01111/miR-3924/DUSP1 axis ] Western Blot//Wound Healing Assay//Invasion Assay//CCK8//qRT-PCR//Luciferase Report Assay//Microarray//Colony Formation Assay//EdU Staining//IF Here, we report a novel lncRNA, LINC01111, that is clearly downregulated in PC tissues and plasma of PC patients and acts as a tumor suppressor. Overall, these data reveal that LINC01111 is a potential diagnostic biomarker for PC patients, and the newly identified LINC01111/miR-3924/DUSP1 axis can modulate PC initiation and development. We found that the LINC01111 level was negatively correlated with the TNM stage but positively correlated with the survival of PC patients. Yes The overexpression of LINC01111 significantly inhibited cell proliferation, the cell cycle, and cell invasion and migration in vitro, as well as tumorigenesis and metastasis in vivo. Conversely, the knockdown of LINC01111 enhanced cell proliferation, the cell cycle, and cell invasion and migration in vitro, as well as tumorigenesis and metastasis in vivo. 31767833 LINC01243 LncRNA Homo sapiens Endometrial Neoplasms regulation[up-regulation] Flow Cytometry//qRT-PCR//Transwell Assay We first confirmed the partial knockdown of both LINC01133 and LINC01243 expression in Ishikawa and HEC-1-A cells using RT-qPCR. Following confirmation of lncRNA knockdown, we assessed the effect of knockdown on EC malignancy. Yes Furthermore, Transwell and scratch invasion assays revealed decreased migration and invasion of the two EC cell lines, respectively. 32929617 LINC01224 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Interaction(miR-193a-5p/NUP210 Axis) RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In this study, LINC01224 was highly expressed in TNBC cells.Additionally, LINC01224 stabilized NUP210 mRNA through interaction with miR-193a-5p, thereby aggravating the malignant phenotypes of TNBC. Yes Moreover, LINC01224 downregulation inhibited TNBC cell proliferation, migration, and invasion, and promoted cell apoptosis. 36127622 LINC01215 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial GEO(10 normal samples and 53 ovarian cancer samples) Expression [highly expressed] CCK8//qRT-PCR//RNA Pull-Down LINC01215 was identified as an upregulated long noncoding RNA (lncRNA) in EOC Yes Overexpressing LINC01215 contributed to downregulated levels of RUNX3, as demonstrated by the recruitment of methylation-related proteins. Silencing of LINC01215 elevated the expression of RUNX3, thus suppressing cell proliferation, migration, invasion and EMT and decreasing the expressions of MMP-2, MMP-9 and Vimentin, but increased the expression of E-cadherin.  34052627 LINC01198 LncRNA Homo sapiens Glioma cell lines regulation[PI3K/AKT pathway] RNA Pull-Down//IHC//Western Blot//Co-IP//Tunel//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//ChIP In our study, LINC01198 was proved to be up-regulated in glioma cell lines, and silenced LINC01198 curbed glioma cell proliferation and accelerated cell apoptosis. Jointly, LINC01198 activates PI3 K/AKT signalling to exert oncogenic function in gliomagenesis by regulating PIK3CA and PTEN, which highlights a new approach for glioma treatment. Yes In our study, LINC01198 was proved to be up-regulated in glioma cell lines, and silenced LINC01198 curbed glioma cell proliferation and accelerated cell apoptosis. 32378450 LINC01197 LncRNA Mus musculus Arthritis, Rheumatoid synovial tissues regulation[microRNA-150/THBS2 axis] qRT-PCR LINC01197 was poorly expressed in the synovial tissues in the RA model mice.The current study suggested that LINC01197 sponged miR-150 to promote THBS2 expression, leading to TLR4/NF-κB inactivation, and ameliorated RA inflammation. These findings may offer new insights into RA treatment. Yes Overexpression of LINC01197 reduced RA severity in mice and inhibited proliferation and inflammatory responses as well as promoted apoptosis in RA-FLS. 32540401 LINC01194 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and NSCLC lines regulation[LINC01194/miR-486-5p Axis] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay LncRNA LINC01194 was highly expressed in NSCLC tissues and NSCLC lines (A549, H1299, H460 cells, H1975), and lncRNA LINC01194 significantly promoted cell proliferation and migration of NSCLC cells.LncRNA LINC01194 promoted the progression of NSCLC by modulating the miR-486-5p/CDK4 axis. Yes LncRNA LINC01194 was highly expressed in NSCLC tissues and NSCLC lines (A549, H1299, H460 cells, H1975), and lncRNA LINC01194 significantly promoted cell proliferation and migration of NSCLC cells. 32346298 LINC01194 LncRNA Homo sapiens Colorectal Neoplasms cell lines Expression[highly expressed] Western Blot//Migration Assay//CCK8//qRT-PCR//Cell Cycle Assay//Invasion Assay Using RT-PCR, we found that Linc01194 is highly expressed in HCT116 cells. In the survival analysis, we found that Linc01194 is correlated with poor survival of colon cancer patients. Yes In addition, by suppressing the expression of Linc01194 in colon cancer cell lines, cell proliferation and migration were inhibited. 30962722 LINC01194 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and in clinical samples Interaction(miR-655-3p/SMAD ) Western Blot//CCK8//qRT-PCR//Cell Apoptosis Assay//Transwell Assay LINC01194 was overexpressed in HCC cells and in clinical samples. We also confirmed that miR-655-3p could bind to LINC01194, and miR-655-3p was downregulated in HCC. The upregulation of miR-655-3p suppressed HCC cell invasion and migration, and enhanced the number of apoptotic cells. SMAD5, which was overexpressed in HCC cell lines, was directly targeted by miR-655-3p. Yes ILINC01194 silencing suppressed proliferation and migration; however, it promoted apoptosis in HCC cell lines. 34978464 LINC01194 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines regulation[miR-641/SETD7 axis] Western Blot//Tunel//Flow Cytometry//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay LINC01194 was significantly upregulated in LUAD tissues and cell lines. LINC01194 promotes the progression of LUAD by enhancing miR-641-targeted SETD7. The LINC01194/miR-641/SETD7 axis might provide new molecular targets for treating LUAD. Yes Knockdown of LINC01194 resulted in decreased cell proliferation, migration and invasion, and increased apoptosis. 33372601 LINC01194 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissue regulation[miR-655,SOX18 ] qRT-PCR//Luciferase Report Assay//RNA Pull-Down We found that the expression levels of LINC01194 were highly expressed in LSCC, which was negatively correlated with the clinical outcome of LSCC patients. Furthermore, we elucidated that LINC01194 promoted SOX18 expression in LSCC cells via functioning as a molecular sponge for miR-655. We found that the expression levels of LINC01194 were highly expressed in LSCC, which was negatively correlated with the clinical outcome of LSCC patients. Yes Functional assays indicated that LINC01194 knockdown distinctly inhibited LSCC cells proliferation, induced apoptosis, and also attenuated LSCC cells migration and invasion in vitro. 32703403 LINC01189 LncRNA Homo sapiens Carcinoma, Hepatocellular HCV-infected HCC tumors and cell lines Interaction(Hsa-miR-155-5p ) Cell Proliferation Assay//qRT-PCR//Luciferase Report Assay LINC01189 is downregulated in HCV-infected HCC tumors and cell lines.Hsa-miR-155-5p was confirmed to be a ceRNA target of LINC01189 in HCC. Upregulating hsa-miR-155-5p reversed the LINC01189-mediated inhibition on HCC proliferation and 5-FU chemoresistance. Yes LINC01189 overexpression inhibited HCC cancer cell proliferation and 5-FU chemoresistance. 33059056 LINC01186 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and an NPC cell line Expression[lower expressed] Wound Healing Assay//CCK8//qRT-PCR//Cell Apoptosis Assay//Transwell Assay In the present study, the expression of lncRNA ZNF674-1 in NPC tissues and an NPC cell line was analyzed and was revealed to be downregulated compared with normal tissues and cells. Yes When the expression of lncRNA ZNF674-1 was reduced in NPC cells, the proliferation, migration and invasion of these cells was promoted, whereas the apoptosis of these cells was decreased. On the contrary, when overexpressed, the expression of lncRNA ZNF674-1 inhibited the proliferation, invasion and migration of cells, but promoted cell apoptosis. 29805695 LINC01160 LncRNA Homo sapiens Nasopharyngeal carcinoma regulation[STAT1 ] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay LINC01160 is upregulated in NPC and can promote a malignant cell phenotype. Yes STAT1 is a transcription factor of LINC01160 and can promote a malignant cell phenotype through upregulating LINC01160 expression. 33263259 LINC01152 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[IL-23] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay In this study we found that the expression of LINC01152 was significantly increased in HBV positive HCC tissues and cells and was induced by HBx in vitro.Mechanistically, HBx could increase the transcription of LINC01152. Elevated LINC01152 binds to the promoter region of IL-23, promoting its transcriptional activity and upregulating the levels of Stat3 and p-Stat3. Our findings suggest that LINC01152 plays an important role in HBV-related hepatocellular carcinoma development and may serve as a therapeutic marker for hepatocellular carcinoma. Yes The overexpression of LINC01152 could increases HCC cell proliferation and promotes tumor formation in nude mice 31054511 LINC01140 LncRNA Homo sapiens Lung Neoplasms LC and paracancerous tissues Regulation In Vivo Experiment We found that LINC01140 was highly expressed in human LC tissues and cell lines. High LINC01140 levels were associated with poor survival in patients with LC. LINC01140 upregulation promoted the proliferation, migration, and invasion of LC cells through direct interaction with miR-33a-5p and miR-33b-5p, thereby contributing to c-Myc expression and also inhibited cisplatin-induced cell apoptosis. Yes In subcutaneous tumor xenograft mice, LINC01140 knockdown markedly reduced tumor growth and lung metastasis. 34446576 LINC01140 LncRNA Homo sapiens Urinary Bladder Neoplasms MIBC tissues regulation[LINC01140/miR-140-5p/FGF9 axis] Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//H&E Staining//ELISA//Transwell Assay//IF The long noncoding RNA (lncRNA) LINC01140 was positively correlated with FGF9 and was significantly upregulated in MIBC tissues. In conclusion, LINC01140, miR-140-5p, and FGF9 form a lncRNA-miRNA-mRNA axis that modulates the bladder cancer phenotype, affects macrophage M2 polarization through the tumor microenvironment, and in turn affects bladder cancer cell aggressiveness. Yes LINC01140 knockdown inhibited the viability, migratory capacity and invasive capacity of T24 cells; culture in si-LINC01140-CM also inhibited macrophage M2 polarization, while promoting M1 polarization. 33234721 LINC01140 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Interaction(miR-139-5p/HOXA9 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay LINC01140 was overexpressed in osteosarcoma and knocking down LINC01140 restrained the proliferation and invasion of osteosarcoma cells and EMT. In Saos2 and MG63 cells, LINC01140 sponged miR-139-5p, and a miR-139-5p inhibitor overturned the suppression of LINC01140 knockdown on the proliferation and migration of osteosarcoma cells. Moreover, miR-139-5p depressed the invasion, proliferation, and EMT of osteosarcoma cells via targeting HOXA9. Yes LINC01140 was overexpressed in osteosarcoma and knocking down LINC01140 restrained the proliferation and invasion of osteosarcoma cells and EMT. 35800618 LINC01140 LncRNA Homo sapiens Glioma Glioma Cells regulation[miR-199a-3p/ZHX1 Axis] CCK8//qRT-PCR//Western Blot The expressions of LINC01140 were promoted in glioma. LINC01140 could promote glioma developments by modulating the miR-199a-3p/ZHX1 axis. Yes Silencing LINC01140 could inhibit glioma cell viabilities, migration, and invasion. 32184618 LINC01139 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC specimens and cell lines regulation[MYBL2,miR-30] qRT-PCR We found that LINC01139 was over-expressed in HCC specimens and cell lines, and its upregulation was observed to be associated with advanced TNM stage, lymph node metastasis and poor clinical prognosis of HCC patients. Overall, LINC01139 may exhibit an oncogenic function in HCC via acting as a sponge for miR-30 to upregulate MYBL2, and may serve as a potential therapeutic target and a prognostic biomarker for HCC patients. We found that LINC01139 was over-expressed in HCC specimens and cell lines, and its upregulation was observed to be associated with advanced TNM stage, lymph node metastasis and poor clinical prognosis of HCC patients. Multivariate analyses confirmed that LINC01139 expression was an independent poor prognostic factor for HCC patients. Yes Functionally, the knockdown of LINC01139 suppressed cell proliferation, clone formation and metastasis of HCC cells. 32115147 LINC01139 LncRNA Homo sapiens pancreatic adenocarcinoma blood Interaction[ROCK1 ] Western Blot//CCK8//qRT-PCR//ELISA//Transwell Assay In the present study, it was determined that the plasma levels of LINK-A lncRNA and Rho-associated protein kinase 1 (ROCK1) were significantly increased in patients with pancreatic adenocarcinoma compared with those in healthy controls. Overexpression of LINK-A lncRNA led to upregulation of ROCK1 expression, while overexpression of ROCK1 had no significant effect on LINK-A lncRNA expression. It may therefore be concluded that LINK-A lncRNA may have a role in pancreatic adenocarcinoma, at least in part, by promoting ROCK1 expression. Yes Silencing of LINK-A led to inhibition of pancreatic adenocarcinoma cell proliferation, migration and invasion. Simultaneous overexpression of ROCK1 attenuated the inhibitory effect of LINK-A silencing on cancer cell proliferation, migration and invasion. 32104251 LINC01139 LncRNA Homo sapiens Osteosarcoma blood Interaction[Expression[highly expressed]regulating HIF1α] qRT-PCR//Transwell Assay//Western Blot The results demonstrated that plasma levels of LINK-A lncRNA were significantly higher in patients with metastatic osteosarcoma (MO) compared with healthy controls and patients with non-metastatic osteosarcoma (NMO). Expression[up-expression]regulated expression of hypoxia-inducible factor 1α (HIF1α) was observed in cancer cells following LINK-A lncRNA overexpression. Exogenous HIF1α treatment did not significantly affect the expression of LINK-A lncRNA in cancer cells, whereas treatment with an HIF1α inhibitor significantly attenuated the effects of LINK-A lncRNA overexpression on cancer cell migration and invasion. Yes LINK-A lncRNA overexpression significantly promoted cancer cell migration and invasion in osteosarcoma cell lines MG-63 and U20S. 31186711 LINC01224 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-2467) RNA Pull-Down//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//cell invasion assay//Colony Formation Assay Presently, LINNC01224 expression was elevated and miR-2467 expression was down-regulated in NSCLC, compared with standard control. Then we described the reciprocal correlation between LINC01224 and miR 2467. Afterward, the dual-luciferase reporter assay, RIP assay and RNA pull-down assay validated the base-pair interaction between LINC01224 and miR-2467. Yes Moreover, our findings demonstrated that the silence of LINC01224 inhibited cell proliferation and invasion in NSCLC and enhanced cisplatin (CDDP) sensitivity in vitro. Besides, rescue assays verified that miR-2467 inhibitor could reverse the effects on cell biological activities and CDDP resistance caused by knockdown of LINC01224. Finally, in vivo experiments implicated that knockdown of LINC01224 could inhibit NSCLC tumor growth. 34403779 LINC01224 LncRNA Homo sapiens Endometrial Neoplasms EC tumor tissue and cell lines Interaction(miR‑485‑5p/AKT3 ) qRT-PCR//RNA Pull-Down//Western Blot LINC01224 expression was significantly upregulated in both EC tumor tissue and cell lines. LINC01224 directly bound to and downregulated miR‑485‑5p to elevate the expression levels of AKT3, thereby promoting EC progression. The present data demonstrated the expression levels, clinical relevance and functional mechanism of LINC01224 in EC. LINC01224 promoted EC development via sponging miR‑485‑5p to elevate AKT3 expression levels; this may provide a promising therapeutic target pathway for EC treatment. The upregulation of LINC01224 was negatively associated with survival of patients with EC. Yes Functionally, LINC01224 promoted proliferation and inhibited apoptosis of EC cells; LINC01224 depletion in EC cells hindered tumor growth in a xenograft model. 34278482 LINC01116 LncRNA Rattus norvegicus Glioma glioma tissues Interaction(microRNA‑744‑5p‑MDM2‑p53 axis) In Vivo Experiment//Western Blot//Tunel//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay LINC01116 was found to be highly expressed in glioma tissues, which was associated with a malignant phenotype. LINC01116 promoted the proliferation and invasiveness of glioma cells, and inhibited the p53 pathway by preserving the expression of MDM2 mRNA via miR‑744‑5p sponging. Furthermore, a low degree of miR‑744‑5p expression was observed in glioma tissues, which was negatively associated with the expression of LINC01116. Overexpression of miR‑744‑5p inhibited the proliferation and invasiveness of glioma cells, which was rescued by LINC01116. Finally, LINC01116 knockdown inhibited tumor growth in nude mice. In conclusion, LINC01116 is aberrantly expressed and promotes the progression of glioma by regulating the miR‑744‑5p‑MDM2‑p53 pathway. In future, targeting LINC01116 may therefore be a potential therapeutic approach for patients with glioma. Yes Furthermore, a low degree of miR‑744‑5p expression was observed in glioma tissues, which was negatively associated with the expression of LINC01116. Overexpression of miR‑744‑5p inhibited the proliferation and invasiveness of glioma cells, which was rescued by LINC01116. Finally, LINC01116 knockdown inhibited tumor growth in nude mice. 33760190 LINC01224 LncRNA Homo sapiens Colonic Neoplasms CC tumor tissues and CC cell lines Interaction(miR-485-5p/MCL1) qRT-PCR//Western Blot LINC01224 was highly expressed in CC tumor tissues and CC cell lines, and its expression was associated with the overall survival of CC patients. LINC01224 was verified to sponge miR-485-5p and consequently targeted MCL1. MiR-485-5p inhibitor or MCL1 overexpression (MCL1 OE) markedly restored the repressive effect of the si-LINC01224 pool on MCL1 expression level, as well as proliferation, migration, and invasion of HT29 and SW480 cells. LINC01224 was highly expressed in CC tumor tissues and CC cell lines, and its expression was associated with the overall survival of CC patients. Yes The LINC01224-siRNAs (si-LINC01224) markedly suppressed the level of LINC01224 in CC cell lines (HT29 and SW480 cells) and consequently significantly suppressed the proliferation, migration, and invasion of the HT29 and SW480 cells. 34675675 LINC01235 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues Expression(highly expressed) Western Blot//Invasion Assay//qRT-PCR//Bioinformatics Analysis//Transwell Assay The qRT-PCR assay confirmed that LINC01235 is significantly over-expressed in GC cells and tissues. Additionally, the overall survival analysis showed that patients with a higher LINC01235 expression had a poorer prognosis than those with a lower LINC01235 expression. Univariate Cox regression analysis indicated that high LINC01235 expression is positively correlated with poor prognosis. Yes Invitro assays suggested that LINC01235 knockdown suppresses GC cell migration and invasion. GSEA revealed that high LINC01235 expression is strongly enriched in the EMT pathway. Western blotting results revealed that LINC01235 silencing decreases the expression of EMT-induced proteins. 33771634 LINC01234 LncRNA Homo sapiens Breast Neoplasms BC tissues, BC cell Interaction(miR-525-5p/CSDE1 ) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay We screened out LINC01234, found to be significantly increased in BC tissues, associated with a poor prognosis, and positively correlated with tumor size of BC. Dual-luciferase reporter®, RNA pull-down, and RNA immunoprecipitation assays confirmed that LINC01234 and CSDE1 directly interacted with miR-525-5p. Upregulation of miR-525-5p and suppression of CSDE1 inhibited BC cell growth and induced cell apoptosis. We screened out LINC01234, found to be significantly increased in BC tissues, associated with a poor prognosis, and positively correlated with tumor size of BC. Yes Knockdown of LINC01234 suppressed BC cell growth and facilitated apoptosis. 35923244 LINC01234 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung tissue interaction[HNRNPA2B1,miR-106b] qRT-PCR//RNA Pull-Down LINC01234 was overexpressed in NSCLC compared with normal lung tissue and correlated positively with poor prognosis. We identified numerous lncRNAs with dysregulated expression in NSCLC and demonstrated a novel oncogenic axis involving LINC01234, HNRNPA2B1, miR-106b-5p, CRY2, and c-Myc. Components of this axis may be potential novel targets for NSCLC. LINC01234 was overexpressed in NSCLC compared with normal lung tissue and correlated positively with poor prognosis. Yes Downregulation of LINC01234 impaired cell proliferation in vitro and tumor growth in vivo. 32246902 LINC01234 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Interaction(LINC01234/miR-433-3p/GRB2 ) CCK8//Colony Formation Assay//EdU Staining LINC01234 was abundantly expressed in NSCLC cells. LINC01234 competitively bound to miR-433-3p and miR-433-3p directly targeted GRB2. miR-433-3p knockdown or GRB2 overexpression counteracted the repressive effect of LINC01234 silencing on NSCLC cell malignant proliferation. Yes LINC01234 silencing reduced NSCLC cell proliferation while LINC01234 overexpression enhanced cell proliferation. 35747966 LINC01234 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer cell lines and tissues regulation[miR-1284/TRAF6 axis] qRT-PCR First, we found that LINC01234, localized in the cytoplasm, was increased in both colorectal cancer cell lines and tissues.Collectively, this study clarified the biological significance of LINC01234/miR-1284/TRAF6 axis in colorectal cancer progression, providing insights into LINC01234 as novel potential therapeutic target for colorectal cancer therapeutic from bench to clinic. Yes Subsequent functional assays suggested LINC01234 knockdown suppressed cell proliferation, migration, and invasion of colorectal cancer cells, while blocked cell cycle and induced cell apoptosis. 31904146 LINC01234 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and CRC cell lines regulation[KLF6 ] qRT-PCR LINC01234 expression was significantly upregulated in CRC tissues and CRC cell lines than in non-tumor tissues and normal epithelial cells, respectively. LINC01234 could be a prognostic biomarker in CRC patients. Upregulation of LINC01234 in CRC promotes tumor development through negative regulation of KLF6. LINC01234 was associated with high tumor stage, larger tumor size, and metastasis. Yes Cell proliferation was inhibited by LINC01234 knockdown, whereas apoptosis was enhanced. 31650732 LINC01234 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(ASS1/p53) qRT-PCR Clinically, LINC01234 was highly expressed in HCC, and a high LINC01234 expression level was correlated with a poor prognosis of patients with HCC. Mechanistically, LINC01234 downregulated the expression of ASS1, leading to am increased aspartate level and activation of the mammalian target of rapamycin pathway. LINC01234 bound to the promoter of ASS1 and inhibited transcriptional activation of ASS1 by transcriptional factors, including p53. Clinically, LINC01234 was highly expressed in HCC, and a high LINC01234 expression level was correlated with a poor prognosis of patients with HCC. Yes LINC01234 promoted cell proliferation, migration, and drug resistance by orchestrating aspartate metabolic reprogramming in HCC cells. Finally, inhibiting LINC01234 dramatically impaired tumor growth in nude mice and sensitized HCC cells to sorafenib. 35192933 LINC01234 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(microRNA-27b-5p) qRT-PCR//Bioinformatics Analysis//Western Blot Up-regulated LINC01234 exhibited in OC tissues and cells. LINC01234 could restore SIRT5 expression by binding to miR-27b-5p. Down-regulated miR-27b-5p reversed the effect of silenced LINC01234 on OCSCs development and tumorigenesis in vivo. Yes Down-regulated LINC01234 or elevated miR-27b-5p suppressed OCSCs progression and tumorigenesis in vivo. 35230909 LINC01234 LncRNA Homo sapiens Esophageal Neoplasms esophageal cancer cells Expression[highly expressed] qRT-PCR Expression of lncRNA LINC01234 was found to be markedly upregulated in the CEC2 cell line. Yes After this, the LINC01234 knockdown effects on cell proliferation, migration, invasion, and apoptosis were evaluated by cell proliferation assay, wound healing assay, invasion assay, and flow cytometric analysis in vitro. 30519325 LINC01234 LncRNA Homo sapiens Multiple Myeloma Multiple myeloma tissues Regulation[miR-124-3p/GRB2 axis] RNA Pull-Down//Western Blot//ISH//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//EdU Staining Our results indicated that LINC01234 was over-expressed in tumor tissues of MM patients.In this study, a novel established regulatory manner of LINC01234/miR-124-3p/GRB2 axis was systematically studied, which may hold promise as a promising target for MM treatment. Yes Our results indicated that LINC01234 was over-expressed in tumor tissues of MM patients, and LINC01234 down-regulation remarkably inhibited cell proliferation, cycle progression and promoted cell apoptosis in MM cells. 31737211 LINC01234 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer cells and tissues Interaction(miR-513a-3p/H6PD ) Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay LINC01234 and H6PD levels were elevated while miR-513a-3p level was reduced in pancreatic cancer cells and tissues.MiR-513a-3p depletion or H6PD elevation could abrogate the inhibitory effects of LINC01234 silencing on pancreatic cancer cells. LINC01234 sponged miR-513a-3p that targeted H6PD. Yes LINC01234 deficiency hindered the malignant biological activities of pancreatic cancer cells. 36343541 LINC01234 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[regulating OTUB1 ] qRT-PCR In this study, we first found that LINC01234 expressions were distinctly upregulated in both NSCLC samples and cell lines using RT-PCR.Mechanistic investigations revealed LINC01234 promotes the progression of NSCLC cells by the modulation of miR-140 to positively regulate OTUB1 expression. The results form clinical investigations indicated that high LINC01234 expressions were associated with positively lymph node metastasis and advanced tumor-metastasis-node (TMN) stage. Kaplan-Meier assays indicated that patients with NSCLC having high LINC01234 expressions tend to have unfavorable clinical prognosis. Using multivariate assays, it was confirmed that LINC01234 was an independent prognostic factor for patients with NSCLC. Yes In vitro assays showed that inhibition of LINC01234 suppressed NSCLC cell proliferation, cell colony formation and metastasis, and greatly promoted apoptosis. 31106421 LINC01234 LncRNA Homo sapiens Carcinoma, Renal Cell regulation[ HIF-2α] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Together, these datas showed that LINC01234 was likely to regulate the progression of ccRCC by HIF-2α pathways, and LINC01234 was both a promising prognostic biomarker and a potential therapeutic target for ccRCC. Yes LINC01234 knockdown impaired cell proliferation, migration and invasion in vitro as compared to negative control. 33088626 LINC01234 LncRNA Homo sapiens Melanoma melanoma cells Interaction(miR-625-5p/PKM2 axis) qRT-PCR Functional analysis of two SFPQ-enriched lncRNA, LINC00511 and LINC01234, demonstrated that these genes independently contribute to the melanoma phenotype and a more detailed analysis of LINC00511 indicated that this occurs in part via modulation of the miR-625-5p/PKM2 axis. Yes Functional analysis of two SFPQ-enriched lncRNA, LINC00511 and LINC01234, demonstrated that these genes independently contribute to the melanoma phenotype and a more detailed analysis of LINC00511 indicated that this occurs in part via modulation of the miR-625-5p/PKM2 axis. 34218270 LINC01232 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cells Interaction(miR-506-5p/PAK1 Axis) Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay LINC01232 was overexpressed in gastric cancer tissues and cells, and mainly located in nucleus. MiR-506-5p was downregulated in gastric cancer tissues and cells. LINC01232 sponged miR-506-5p to accelerate migration and EMT. PAK1 was certified to be a target of miR-506-5p, inhibition of PAK1 could interrupt LINC01232 overexpression-induced migration of gastric cancer cells. Yes The inhibition of LINC01232 could suppress migration, invasion and EMT of gastric cancer cells. 35592108 LINC01232 LncRNA Homo sapiens Urinary Bladder Neoplasms BC cell lines Interaction(miR-370-5p/PIM3 axis) qRT-PCR//FISH In the current study, we detected LINC01232 expression utilizing quantitative real-time polymerase chain reaction (RT-qPCR) and discovered that LINC01232 was overexpressed in BC cell lines versus normal cell line. Next, miR-370-5p was proved to bind with LINC01232 by RNA pull down, RNA-binding protein immunoprecipitation (RIP) and luciferase reporter assays. Furthermore, PIM3 expression was negatively modulated by miR-370-5p and markedly increased in BC cell lines. Moreover, PIM3 silence repressed proliferation, migration and invasion but triggered apoptosis of BC cells. The rescue assays validated that upregulation of PIM3 recovered the effects of LINC01232 silence on the growth of BC cells. Yes Functionally, LINC01232 deficiency suppressed cell proliferation, migration and invasion. 35338769 LINC01232 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Interaction(IGF2BP2/TGFBR1) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//ChIP RT-qPCR results revealed that LINC01232 expression was high in NSCLC cells.Luciferase reporter assay and ChIP assay validated that forkhead box P3 (FOXP3) could bind to LINC01232 promoter and activate LINC01232 transcription. Further, LINC01232 was certified to activate TGF-β signaling pathway through regulating transforming growth factor beta receptor 1 (TGFBR1). After RIP and RNA pull down assays, insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) was proven as the RNA-binding protein (RBP) for LINC01232. LINC01232 promoted TGFBR1 mRNA stability via recruiting IGF2BP2. Subsequently, LINC01232 was verified to accelerate NSCLC cell stemness and induce macrophage M2 polarization via upregulating TGFBR1. Yes Flow cytometry and sphere formation assays indicated that LINC01232 significantly promoted NSCLC cell stemness. 35026283 LINC01224 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-2467 ) CCK8//qRT-PCR LINC01224 expression was observed to be up-regulated in CRC tissues and cell lines. Functional studies suggested that LINC01224 silence inhibited CRC cells proliferation and invasion of CRC cells, while co-transfection with a miR-2467 inhibitor reversed these biological effects. Yes Functional studies suggested that LINC01224 silence inhibited CRC cells proliferation and invasion of CRC cells, while co-transfection with a miR-2467 inhibitor reversed these biological effects. 33542656 LINC01224 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue samples and cell lines Interaction(miR-485-5p/MYO6 axis) qRT-PCR//Transwell Assay//RIP//ChIP LINC01224 abundance was elevated in CRC tissue samples and cell lines. MiR-485-5p was sponged by LINC01224, and miR-485-5p downregulation relieved the influence of LINC01224 interference on CRC progression. MYO6 was targeted via miR-485-5p and regulated via LINC01224/miR-485-5p axis. MiR-485-5p overexpression suppressed CRC cell proliferation, migration, and invasion and facilitated apoptosis. MYO6 upregulation mitigated the role of miR-485-5p. Elevated LINC01224 might indicate the lower 5-year overall survival in 52 CRC patients. Yes LINC01224 was upregulated via the transcription factor YY1. LINC01224 knockdown restrained CRC cell proliferation, migration, and invasion and increased apoptosis. LINC01224 knockdown decreased xenograft tumor growth. 34535152 LINC01139 LncRNA Homo sapiens Osteosarcoma patients with osteosarcoma regulation[TGF-β1] Flow Cytometry//qRT-PCR//ELISA//Transwell Assay LINK-A lncRNA and TGF-β1 were upregulated in patients with osteosarcoma compared with healthy controls. These data indicated that LINK-A lncRNA is upregulated in osteosarcoma and may regulate migration, invasion and stemness of osteosarcoma cells through TGF-β1. Yes LINK-A lncRNA shRNA silencing inhibited, whereas TGF-β1 treatment promoted cell migration, invasion and stemness. 32218837 LINC01139 LncRNA Homo sapiens Ovarian Neoplasms ovarian tissues Interaction[HIF1α] qRT-PCR As shown in Figure 1, compared with the control groExpression[Expression[up-expression]-expression], LINK-A was significantly higher in patients with the 3 types of metastatic ovarian carcinoma (p<0.05), while no significant difference in LINK-A expression was found between non-metastatic ovarian carcinoma and healthy controls (p>0.05). In addition, LINK-A overexpression also significantly promoted migration (p<0.05, Figure 4B) and invasion (p<0.05, Figure 4C) of cancer cells. We found that LINK-A was significantly higher in ovarian carcinoma patients than in healthy controls in ovarian biopsies and in serum. LINK-A expression effectively distinguished patients with metastatic ovarian carcinoma from healthy controls. LINK-A overexpression promoted cancer cell migration and invasion, and also Expression[Expression[up-expression]-expression]regulated the expression of HIF1alpha. As shown in Figure 1, compared with the control groExpression[Expression[up-expression]-expression], LINK-A was significantly higher in patients with the 3 types of metastatic ovarian carcinoma (p<0.05), while no significant difference in LINK-A expression was found between non-metastatic ovarian carcinoma and healthy controls (p>0.05). These data suggest that Expression[Expression[up-expression]-expression]regulation of LINK-A in ovarian tissues participates in the distant metastasis of ovarian carcinoma. Yes As shown in Figure 1, compared with the control groExpression[Expression[up-expression]-expression], LINK-A was significantly higher in patients with the 3 types of metastatic ovarian carcinoma (p<0.05), while no significant difference in LINK-A expression was found between non-metastatic ovarian carcinoma and healthy controls (p>0.05). In addition, LINK-A overexpression also significantly promoted migration (p<0.05, Figure 4B) and invasion (p<0.05, Figure 4C) of cancer cells. 30912527 LINC01139 LncRNA Homo sapiens Diabetic Nephropathies diabetic nephropathy tissues Interaction[HIF1α] qRT-PCR//ELISA//Western Blot The results revealed that LINK-A lncRNA and HIF1α were downregulated in patients with diabetic nephropathy, as well as in diabetic patients without complications. LINK-A lncRNA overexpression also promoted HIF1α expression in mouse podocyte cells, while HIF1α overexpression did not significantly affect LINK-A lncRNA expression. Yes LINK-A lncRNA and HIF1α overexpression inhibited the apoptosis of mouse podocyte cells under a high glucose treatment. 31258644 LINC01139 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Regulation Transfection//Wound Healing Assay//qPCR//MTT//Cell Cycle Assay//Colony Formation Assay//Transwell Assay LINK-A down-regulation significantly reduced cell viability, colony-forming ability and cell migration, as measured by MTT, colony formation and invasion assays. Finally, cell cycle analysis and Annexin-V/7AAD staining indicated that apoptosis was influenced by LINK-A silencing. Yes LINK-A down-regulation significantly reduced cell viability, colony-forming ability and cell migration, as measured by MTT, colony formation and invasion assays. Finally, cell cycle analysis and Annexin-V/7AAD staining indicated that apoptosis was influenced by LINK-A silencing. 33602983 LINC01128 LncRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-27b-3p) qRT-PCR//Luciferase Report Assay//Transwell Assay LINC01128 was up-regulated in glioma tissues and cells. Silencing LINC01128 targeting miR-27b-3p inhibited the proliferation, migration, and invasion activity of glioma cells. Moreover, there was a negative correlation between LINC01128 and miR-27b-3p. Yes Silencing LINC01128 targeting miR-27b-3p inhibited the proliferation, migration, and invasion activity of glioma cells. Moreover, there was a negative correlation between LINC01128 and miR-27b-3p. 36382487 LINC01127 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Interaction[ERK and AKT] Flow Cytometry//qRT-PCR//Western Blot LINC01127 expression in ovarian cancer tissues was significantly higher than that in normal ovary tissues. LINC01127 may be involved in the development of ovarian cancer by accelerating cell cycle progression through promoting the phosphorylation of ERK and AKT. The expression level of LINC01127 was negatively correlated with the prognosis of patients with ovarian cancer. Yes Tumorigenicity assay in nude mice showed that low expression of LINC01127 inhibited the growth of ovarian tumors. 30787997 LINC01123 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[miR-199a-5p/c-Myc axis] qRT-PCR//RNA-seq//RIP//ChIP Three hundred sixty-four differentially expressed genes were identified in RNA-seq assay, and LINC01123 was one of the most overexpressed lncRNAs. Further validation in expanded NSCLC cohorts confirmed that LINC01123 was upregulated in 92 paired NSCLC tissues and associated with poor survival. Meanwhile, LINC01123 increased c-Myc mRNA expression by sponging miR-199a-5p. In addition, rescue experiments showed that LINC01123 functioned as an oncogene depending on miR-199a-5p and c-Myc. Further validation in expanded NSCLC cohorts confirmed that LINC01123 was upregulated in 92 paired NSCLC tissues and associated with poor survival. Yes Functional assays showed that LINC01123 promoted NSCLC cell proliferation and aerobic glycolysis. 31488218 LINC01123 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-625-5p/LASP1 Axis] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The results show that LINC01123 expression is abnormally elevated in CRC tissues and cell lines.The data indicate that high LINC01123 exerts its oncogenic roles by regulating the miR-625-5p/LASP1 axis in CRC progression. High LINC01123 expression closely correlates with poor prognosis, advanced TNM stage, and lymph-node metastasis. Yes The authors also show that knockdown of LINC01123 inhibits proliferation and invasion in CRC cells. 32423238 LINC01123 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tumor tissues and cells Interaction(SRSF7) qRT-PCR//Wound Healing Assay//RNA Pull-Down//Western Blot LINC01123 was up-regulated in colorectal cancer tumor tissues. The proliferation, invasion and migration ability of colorectal cancer cells were decreased significantly after LINC01123 knockdown, and it may inhibit its expression by interacted with SRSF7, thereby promoting colorectal cancer progression. Yes The proliferation, invasion and migration ability of colorectal cancer cells were decreased significantly after LINC01123 knockdown, and it may inhibit its expression by interacted with SRSF7, thereby promoting colorectal cancer progression. 35325644 LINC01123 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-34a-5p/TUFT1 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Here, we found that the expression of LINC01123 was clearly upregulated in HCC tissues compared to nontumor tissues. In conclusion, LINC01123 was overexpressed in HCC and accelerated cancer cell proliferation and invasion by regulating the miR-34a-5p/TUFT1 axis. Yes Next, we demonstrated that LINC01123 knockdown suppressed the proliferation, migration and invasion of HCC cells in vitro. Depletion of LINC01123 inhibited HCC xenograft growth in vivo. 32760198 LINC01123 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tumor tissues Interaction(miR-34a-5p) qRT-PCR//Luciferase Report Assay The analysis results showed that LINC01123 was overexpressed in OSCC tumor tissues; also, the prognosis of patients with OSCC with high LINC01123 expression levels was poor. MiR-34a-5p was a target of LINC01123, and its inhibitor could reverse the effect of silenced LINC01123 on the progression of OSCC. The analysis results showed that LINC01123 was overexpressed in OSCC tumor tissues; also, the prognosis of patients with OSCC with high LINC01123 expression levels was poor. Yes The knockdown of LINC01123 inhibited the proliferation, migration, and invasion of OCSS cells. 34511356 LINC01123 LncRNA Homo sapiens Osteosarcoma OS cell lines Interaction(miR-516b-5p/Gli1 axis) qRT-PCR//RIP In this study, the expression of LINC01123 was significantly upregulated in OS cell lines than in a human osteoblast cell line. Mechanistically, LINC01123 acted as a competing endogenous RNA by sponging miR-516b-5p, thus, increasing Gli1 expression by directly targeting its 3'UTR. Yes Furthermore, in vitro and in vivo experiments confirmed that knockdown of LINC01123 suppressed cell progression. 33837611 LINC01123 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Interaction(miR-214-3p/B7-H3) Western Blot//Wound Healing Assay//Invasion Assay//Migration Assay//CCK8//FISH//qRT-PCR//Flow Cytometry//ELISA//Bioinformatics Analysis Our results indicated that LINC01123 and B7-H3 were highly expressed in HNSCC and are associated with poor prognosis in patients. Notably, overexpression of LINC01123 or B7-H3 or downregulation of miR-214-3p inhibited the function of CD8+T cells and promoted the progression of HNSCC. Therefore, LINC01123 acts as a miR-214-3p sponge to inhibit the activation of CD8+T cells and promote the progression of HNSCC by upregulating B7-H3. Our results indicated that LINC01123 and B7-H3 were highly expressed in HNSCC and are associated with poor prognosis in patients. Yes Notably, overexpression of LINC01123 or B7-H3 or downregulation of miR-214-3p inhibited the function of CD8+T cells and promoted the progression of HNSCC. 35115487 LINC01116 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[highly expressed] qRT-PCR//Transwell Assay LINC01116 and lncRNA CASC11 were both upregulated in cancer tissues compared to cancer-adjacent tissues. Expression levels of LINC01116 and CASC11 were increased with the increase in clinical stages. Yes Overexpression of LINC01116 and CASC11 led to promoted invasion and migration of gastric cancer cells. 31632064 LINC01116 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells interaction[miR-9-5p/STMN1] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay LINC01116 was expressed higher in CRC tissues and cells. Patients with higher expression of LINC01116 had worse prognosis. Yes Knockdown of LINC01116 suppressed development of CRC cell. 33116633 LINC01116 LncRNA Homo sapiens Urinary Bladder Neoplasms cell lines regulation[regulates ELK3 and HOXD8 ] RNA Pull-Down//ChIP//Western Blot//Colony Formation Assay//Flow Cytometry//qRT-PCR//FISH//IF//RIP//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay In our study, we detected that the expression of LINC01116 was boosted in BCa cells. In conclusion, HOXD8-enhanced LINC01116 contributes to the progression of BCa via targeting ELK3 and HOXD8, which might provide new targets for treating patients with BCa. Yes Moreover, the results of a series of functional assays showed that LINC01116 knockdown suppressed the proliferation, migration, and invasion of BCa cells. 33311496 LINC01116 LncRNA Homo sapiens Glioma glioma tissue,cell lines Interaction[targeted by miR-31] qRT-PCR//Luciferase Report Assay//Transwell Assay Linc01116 is highly expressed in glioma tissue and cells, along with low expression of miR-31, and there was a negative correlation between the expression of linc01116 and miR-31 in glioma tissue. The luciferase gene reporter system had confirmed that linc01116 targeted miR-31 and miR-31 targeted radixin in U251 cells. Moreover, radixin was downregulated and decreased E-cadherin protein expression, but increased MMP-9 and vimentin protein expression in U251 cells. In addition, the expression of linc01116 in glioma patients with metastasis was significantly higher than that in patients without metastasis, while miR-31 was significantly lower. Yes In vitro and in vivo studies shown that linc01116 promoted invasion and migration of glioma cells. 31933922 LINC01116 LncRNA Homo sapiens Glioma glioma tissues Interaction(miR-744-5p/ TGF-β1) In Vivo Experiment//cell invasion assay//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay GEO database and clinical research revealed that the expression level of LINC01116 in glioma increased, and the elevation of LINC01116 was closely related to the adverse prognosis of clinical patients. Western blot analysis and qRT-PCR analysis showed that LINC01116 regulated TGF-β1 by mediating miR-744-5p. Yes Functional experiments showed that the inhibition of LINC01116 could up-regulate miR-744-5p-mediated proliferation and metastasis of glioma cells. Finally, the analysis of animal models in vivo showed that LINC01116 could regulate the tumor growth of glioma. 34150180 LINC01116 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Cell Apoptosis Assay//Cell Cycle Assay//EdU Staining//Transwell Assay In this work, we found that LINC01116 was overexpressed in LUAD tissues and cell lines and that increased expression was significantly associated with worse prognoses in patients with LUAD. In this work, we found that LINC01116 was overexpressed in LUAD tissues and cell lines and that increased expression was significantly associated with worse prognoses in patients with LUAD. Yes Downregulation of LINC01116 significantly inhibited cell proliferation and migration, promoted cell apoptosis, and prevented cell progression from G1 to S phase. 32913506 LINC01116 LncRNA Homo sapiens Adenocarcinoma of Lung LAD tissues and cells Interaction(miR-744-5p/CDCA4 axis) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay LINC01116 was expressed at an abnormally high level in LAD, which was induced by transcription activator EGR1. MiR-744-5p could bind to LINC01116. MiR-744-5p inhibitor reversed the inhibitory effects of silencing LINC01116 on LAD malignant behaviors. In addition, cell division cycle-associated protein 4 (CDCA4) shared binding sites with miR-744-5p. Yes LINC01116 depletion restrained proliferation, migration and invasion, yet facilitated apoptosis of LAD cells. 34090440 LINC01116 LncRNA Homo sapiens Prostatic Neoplasms Human prostate cancer cell lines (DU145, PC3, LNCAP, 22RV1, VCaP) and human prostate epithelial cell line (RWPE-1) Interaction(miR-744-5p/UBE2L3 axis) RNA Pull-Down//Western Blot//FISH//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//IF LINC01116 was found to be highly expressed in prostate cancer cells. Also, miR-744-5p was proven to bind with LINC01116. Moreover, UBE2L3 was verified as the target gene of miR-744-5p. Yes Functional assays indicated that inhibition of LINC01116 could suppress cell proliferation, migration, invasion and EMT progress. 33726770 LINC01116 LncRNA Homo sapiens Small Cell Lung Carcinoma SCLC tissues Interaction(miR-93-5p/STAT3) Transfection//qPCR//Transwell Assay//Western Blot LINC01116 was highly expressed in SCLC and predicted poor survival. In SCLC tissues, the expression of LINC01116 was positively correlated with STAT3. Bioinformatics analysis revealed that miR-93-5p may target LINC01116. LINC01116 was highly expressed in SCLC and predicted poor survival. Yes Overexpression of LINC01116 increased STAT3 but did not affect the expression of miR-93-5p. Transwell assay showed that LINC01116 and STAT3 increased cell invasion and migration rates. MiR-93-5p played an suppressed cell behaviors and suppressed the role of LINC01116. 33535997 LINC01128 LncRNA Homo sapiens Osteosarcoma OS tissues regulation[Wnt/β-catenin signalling pathway] Northern Blot//Western Blot//Flow Cytometry//qRT-PCR//RIP//FISH//Luciferase Report Assay GEO data sets analysis revealed that the expression of LINC01128 was increased in OS. In summary, this study demonstrates that LINC01128 facilitates OS by functioning as a sponge of miR-299-3p, thus promoting MMP2 expression and activating the Wnt/β-catenin signalling pathway. Yes Functional studies revealed that LINC01128 knockdown reduced the proliferation, migration and invasion of OS cells both in vitro and in vivo. 33108067 LINC01132 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC specimens Interaction(microRNA‑431‑5p/SOX9 axis) qRT-PCR//Luciferase Report Assay//RIP//Western Blot Herein, LINC01132 was overexpressed in EOC and was significantly associated with poor patient prognosis. Generally, LINC01132 exhibited oncogenic activities in EOC cells by regulating the outcome of the miR‑431‑5p/SOX9 axis, providing an effective target for EOC diagnosis, therapy and prognosis evaluation. Herein, LINC01132 was overexpressed in EOC and was significantly associated with poor patient prognosis. Yes Functionally, cell experiments revealed that LINC01132 depletion produced cancer?suppressive effects in EOC cells and regulated cell proliferation, migration, invasion and apoptosis in vitro. Additionally, the loss of LINC01132 attenuated tumour growth in vivo. 34132375 LINC01133 LncRNA Homo sapiens Endometriosis ectopic endometriotic lesions Expression(highly expressed) Western Blot//Flow Cytometry//qRT-PCR//RNA-seq//Cell Proliferation Assay//Cell Cycle Assay//IF We found that LINC01133 is upregulated in ectopic endometriotic lesions. Yes Phenotypic assays indicated that LINC01133 may promote proliferation and suppress cellular migration, and affect the cytoskeleton and morphology of the cells. 34445100 LINC01133 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Regulation[ PI3K/AKT pathway] qRT-PCR We observed that LINC01133 was significantly increased in HCC cells including HepG2, Hep3B, MHCC-97L, SK-Hep-1, and MHCC-97H cells compared with the normal human liver cell line HL-7702.Taken these together, we revealed that LINC01133 contributed to HCC progression by activating the PI3K/AKT pathway. Yes Knockdown of LINC01133 was able to inhibit HCC cell proliferation, cell colony formation, cell apoptosis, and blocked cell cycle arrest in the G1 phase. For another, downregulation of LINC01133 repressed HCC cell migration and invasion. 30548306 LINC01139 LncRNA Homo sapiens Lymphoma, Mantle-Cell blood Expression[highly expressed] Cell Proliferation Assay//qRT-PCR//ELISA//Western Blot We found that, compared with healthy controls, plasma levels of LINK-A lncRNA and survivin were significantly increased in patients with mantle cell lymphoma. Yes LINK-A lncRNA overexpression promoted cell proliferation, inhibited cell apoptosis, and upregulated survivin expression, while LINK-A lncRNA knockdown had the opposite effect. 30636001 LINC01138 LncRNA Homo sapiens Adenocarcinoma of Lung A549 and H460 cells Regulation Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay A series of in vitro experiments demonstrated that knockdown of LINC01138 dampened variability, proliferation, and motility of A549 and H460 cells. Yes A series of in vitro experiments demonstrated that knockdown of LINC01138 dampened variability, proliferation, and motility of A549 and H460 cells. 36060239 LINC01134 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[AKT1S1 and NF-κB Signaling] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, via analyzing The Cancer Genome Atlas Liver Hepatocellular Carcinoma dataset, we identified a novel lncRNA LINC01134, which is highly expressed in HCC tissues and correlated with microvascular invasion, macrovascular invasion, recurrence, and poor overall survival of HCC patients.Taken together, these findings recognized LINC01134 as a novel oncogenic lncRNA, which indicates vascular invasion, recurrence, and poor overall survival of HCC patients. LINC01134 promotes HCC metastasis via activating AKT1S1 expression and subsequently activating NF-κB signaling. In this study, via analyzing The Cancer Genome Atlas Liver Hepatocellular Carcinoma dataset, we identified a novel lncRNA LINC01134, which is highly expressed in HCC tissues and correlated with microvascular invasion, macrovascular invasion, recurrence, and poor overall survival of HCC patients. Yes Functional experiments revealed that ectopic expression of LINC01134 promotes HCC cell migration and invasion in vitro and HCC liver metastasis and lung metastasis in vivo. Knockdown of LINC01134 represses HCC cell migration and invasion in vitro and HCC liver metastasis and lung metastasis in vivo. 32656205 LINC01134 LncRNA Homo sapiens Liver Neoplasms cell lines Regulation(p53 ) RNA Pull-Down//Transfection//Wound Healing Assay//qRT-PCR//RNA-seq//Cell Proliferation Assay//Invasion Assay//Transwell Assay Based on the intersection of our own RNA-seq, TCGA RNA-seq, and TCGA survival analysis data, TLNC1 was identified as a potential tumorigenic lncRNA of liver cancer. TLNC1 exerted its tumorigenic function through interaction with TPR and inducing the TPR-mediated transportation of p53 from nucleus to cytoplasm, thus repressing the transcription of p53 target genes and finally contributing to the progression of liver cancer. Yes TLNC1 significantly enhanced the growth and metastasis of hepatoma cells both in vitro and in vivo. 35477447 LINC01133 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction(miR-145-5p/YES1) RNA Pull-Down//IHC//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay In the present study, we found that linc01133 was significantly upregulated in gastric cancer tissues compared to non-tumorous gastric tissues. The expression of linc01133 was regulated by c-Jun and c-Fos collaboratively. Linc01133 localized in the cytoplasm and functioned as an endogenous competing RNA of miR-145-5p to upregulate the expression of YES1, which was proved to be the target gene of miR-145-5p. By promoting YES1-dependent YAP1 nuclear translocation, linc01133 upregulated the expression of the key cell cycle regulators CDK4, CDK6 and cyclin D1 to promote G1-S phase transition. Linc01133 over-expression significantly correlated with tumor size and tumor differentiation in gastric cancer patients. Yes In both in vitro and in vivo studies, linc01133 was shown to promote gastric cancer cell growth. 35017464 LINC01133 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[regulating SOX4 expression through EZH2] ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Transwell Assay In this study, we found that the LINC01133 expression was significantly down-regulated in breast cancer samples and was associated with progression and poor prognosis of breast cancer.Mechanistic investigations revealed that LINC01133 repressed SOX4 expression by recruiting EZH2 to SOX4 promoter. Moreover, rescue experiments further confirmed that LINC01133 functional acted as an anti-oncogene, at least partly, via repressing SOX4 in breast cancer. Taken together, these findings imply that LINC01133 could serve as a novel prognostic biomarker and potential therapeutic target for breast cancer. Yes Further experiments demonstrated that overexpression of LINC01133 inhibited invasion and metastasis in breast cancer both in vitro and in vivo. 31557401 LINC01133 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues and cell lines regulation[miR-495-3p/TPD52 axis] Western Blot//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay We found that LINC01133 was upregulated in EOC tissues and cell lines. Generally, our study showed that LINC01133 interacted with miR-495-3p to promote metastasis in EOC by regulating TPD52. Yes Functional experiments demonstrated that LINC01133 could facilitate cancer cell migration and invasion in vitro and tumor metastasis in vivo. 33036757 LINC01133 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues,cell lines regulation[miR-30b-5p/Rab3D Axis] qRT-PCR The results showed that LINC01133 was highly expressed in RCC tissue specimens and cell lines.Taken together, these findings indicated that LINC01133 might be an oncogene in RCC through regulation of the miR-30b-5p/Rab3D axis. Yes Downregulation of LINC01133 significantly inhibited the proliferation, migration, and invasion of RCC cells. In vivo study showed that LINC01133 knockdown suppressed tumor growth in the nude mice. 33054325 LINC01133 LncRNA Homo sapiens Carcinoma, Hepatocellular 49 patients with HCC(WGS) Interaction(miR-199a-5p/SNAI1) qRT-PCR//Luciferase Report Assay//Western Blot Genomic copy numbers of LINC01133 were increased in HCC, which were positively related with the elevated expression of LINC01133. LINC01133 sponged miR-199a-5p, resulting in enhanced expression of SNAI1, which induced epithelial-to-mesenchymal transition (EMT) in HCC cells. In addition, LINC01133 interacted with Annexin A2 (ANXA2) to activate the ANXA2/STAT3 signaling pathway. Increased copy number of LINC01133 predicted the poor prognosis in HCC patients. Yes LINC01133 overexpression in HCC cells promoted proliferation and aggressive phenotypes in vitro, and facilitated tumor growth and lung metastasis in vivo, whereas LINC01133 knockdown had the opposite effects.  34047479 LINC01133 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction[binding to YBX1] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//Colony Formation Assay//Transwell Assay In this work, we demonstrated that LINC01133 was significantly downregulated in NPC tissues and cell lines. Besides, Fluorescence in situ hybridization (FISH) assay was performed to determine the localization of LINC01133 and LINC01133 was observed mainly distributed in the nucleus. Importantly, RNA pull-down and RIP assays showed that LINC01133 directly combined with YBX1, and YBX1 can partly reverse the repression of NPC cell proliferation, migration, and invasion caused by LINC01133. Collectively, our exploration indicate that LINC01133 inhibits the malignant-biological behavior of NPC cells by binding to YBX1, thereby suggesting a novel biomarker for the NPC prognosis and treatment. Yes Loss and gain of function experiments provided evidence that LINC01133 inhibited NPC cell proliferation, invasion and migration both in vitro and in vivo. 31106003 LINC01133 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissue and cell Interaction[LRRK2] RNA Pull-Down//Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The findings revealed a poor expression of LINC01133 in ovarian cancer tissue and cell, which was predominantly expressed in the cytoplasm. In conclusion, because of its role as an miR-205 sponge, LINC01133 repressed the development of ovarian cancer by up-regulating LRRK2. Yes LINC01133 repressed cell proliferation, invasion, migration, and tumorigenic ability. 31640854 LINC01133 LncRNA Homo sapiens Urinary Bladder Neoplasms exosomes of SV-HUC-1 and low in that of BC cells Expression [highly expressed] qRT-PCR//Western Blot//Transwell Assay We discovered that LINC01133 expression was high in exosomes of SV-HUC-1 and low in that of BC cells. Additionally, exosomes restrained cell viability, proliferation, migration, and invasion. Similarly, LINC01133 exerted the same function on BC cells. In addition, the Wnt signaling pathway could be inactivated by LINC01133. In addition, the Wnt signaling pathway could be inactivated by LINC01133. Yes Additionally, exosomes restrained cell viability, proliferation, migration, and invasion. Similarly, LINC01133 exerted the same function on BC cells. 33728699 LINC01133 LncRNA Homo sapiens Endometrial Neoplasms regulation[up-regulation] Flow Cytometry//qRT-PCR//Transwell Assay We first confirmed the partial knockdown of both LINC01133 and LINC01243 expression in Ishikawa and HEC-1-A cells using RT-qPCR. Following confirmation of lncRNA knockdown, we assessed the effect of knockdown on EC malignancy. Yes Furthermore, Transwell and scratch invasion assays revealed decreased migration and invasion of the two EC cell lines, respectively. 32929617 LINC01133 LncRNA Homo sapiens pancreatic ductal adenocarcinoma Interaction(AXIN2/Wnt/β-catenin pathway ) qRT-PCR//ChIP We analyzed the expression of LINC01133 in PDAC and found that exosomal LINC01133 expression was high and positively correlated with higher TNM stage and poor overall survival rate of PDAC patients. We subsequently evaluated the effect of LINC01133 on the Wnt/β-catenin pathway and confirmed that LINC01133 can interact with Enhancer Of Zeste Homolog 2 (EZH2) and then promote H3K27 trimethylation. This can further silence AXIN2 and suppress GSK3 activity, ultimately activating β-catenin. We analyzed the expression of LINC01133 in PDAC and found that exosomal LINC01133 expression was high and positively correlated with higher TNM stage and poor overall survival rate of PDAC patients. Yes We also observed that LINC01133 promoted the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. 33824474 LINC01133 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Interaction[LINCO1133/miR-4784 ] Migration Assay//CCK8//qRT-PCR//EdU Staining//Transwell Assay LINC01133 expression profile was validated by digging The Cancer Genome Atlas (TCGA) database and qRT-PCR analysis. Mechanically, LINC01133 functioning as a ceRNA targeted miR-4784 to augment AHDC1 expression. Finally, LINCO1133/miR-4784 aggravated the malignant growth and aggressiveness and EMT of cervical cancer in an AHDC1-dependant way. Yes Apoptotic rate of cervical cancer cells was promoted after silencing LINCO1133. 31390932 LINC01133 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissue regulation[miR-30a-5p/FOXD1] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay We observed that LINC01133 expression in CC clinical samples was significantly increased, with high expression associated with higher T stage and negative HPV infection of the patients. LINC01133 was a sponge of tumor suppressor miR-30a-5p, and it enhanced the expression of FOXD1 indirectly and functioned as an oncogenic lncRNA in CC. We observed that LINC01133 expression in CC clinical samples was significantly increased, with high expression associated with higher T stage and negative HPV infection of the patients. Yes Its overexpression remarkably accelerated proliferation and metastasis of CC cells, with reduced apoptosis. 33078907 LINC01133 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Regulation(LINC01133-PROTOR1/PRR5 pathway) RNA Pull-Down//Western Blot//qRT-PCR//FISH//RIP//RNA-seq//IHC We found that LINC01133 exerted protumorigenic roles in TNBC and that it governed a previously undescribed mTOR Complex 2 (mTORC2)-dependent pathway that activated AKT in a PI3K-independent manner. Mechanistically, LINC01133 induced the expression of the mTORC2 component PROTOR1/PRR5 by competitively coupling away its negative messenger RNA (mRNA) regulator, the heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1). PROTOR1/PRR5 in turn was sufficient and necessary for LINC01133-triggered functions, casting previously unappreciated roles for this Rictor-binding protein in cellular signaling and growth. Notably, LINC01133 antagonism undermined cellular growth, and we show that the LINC01133-PROTOR1/PRR5 pathway was tightly associated with TNBC poor patient survival. Yes Notably, LINC01133 antagonism undermined cellular growth, and we show that the LINC01133-PROTOR1/PRR5 pathway was tightly associated with TNBC poor patient survival. 36269860 ELFN1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-1250) colony Formation Assay//In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//Cell Viability Assay//Invasion Assay//Transwell Assay First, we found that ELFN1-AS1 was highly abundant in the human CRC tissues and cell lines. Yes Silence of ELFN1-AS1 expression reduced cell proliferation, colony formation, migration and invasion, while inducing apoptosis in vitro; moreover, knockdown of ELFN1-AS1 decreased the size and weight of tumor in vivo.Luciferase reporter assay revealed that ELFN1-AS1 interacted with miR-1205 and suppressed its expression. 34337713 ELFN1-AS1 LncRNA Homo sapiens Colonic Neoplasms Colon Cancer tissues and cell lines regulation[miR-191-5p/SATB1 axis] CCK8//qRT-PCR//EdU Staining Results uncovered that ELFN1-AS1 expression was prominently raised in colon cancer cells and tissues.To sum up, ELFN1-AS1 drives colon cancer cells to proliferate and invade through adjusting the miR-191-5p/SATB1 axis. Yes ELFN1-AS1 decrement restrained cells to grow through interfering with distribution of cell cycle and promoting apoptosis. 33634016 MANCR LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC cells and tissues Expression(highly expressed) Wound Healing Assay//Flow Cytometry//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay In addition, we revealed that MANCR was highly expressed in ccRCC cells and tissues and downregulation of MANCR inhibited cell proliferation and migration. In contrast, apoptosis of 786-O and SN12C cells was promoted with MANCR suppression. Yes In addition, we revealed that MANCR was highly expressed in ccRCC cells and tissues and downregulation of MANCR inhibited cell proliferation and migration. In contrast, apoptosis of 786-O and SN12C cells was promoted with MANCR suppression. 36217399 hsa_circ_0001093 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Interaction(miR-579-3p/glutaminase axis) RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay Here, we found that circ_0001093 expression was up-regulated in ESCC tissues and cell lines. Mechanistically, circ_0001093 acted as a competing endogenous RNA (ceRNA) by sponging miR-579-3p, thereby increasing GLS expression. Furthermore, the inhibitory effects of circ_0001093 knockdown on the invasion, migration and glutamine metabolism were partly rescued by miR-579-3p inhibition or GLS over-expression in ESCC cells. Additionally, miR-579-3p expression was down-regulated in ESCC tissues, while GLS expression was up-regulated. Increased circ_0001093 expression predicted an unfavourable prognosis, and was associated with the lymph node metastasis, TNM staging and tumor size in ESCC tissues. Yes Circ_0001093 knockdown suppressed cell proliferation, invasion, migration and glutamine metabolism of ESCC cells, while circ_0001093 over-expression showed the opposite effects. 35322289 hsa_circ_0005231 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC plasma, tissues and cells Interaction(miR-383-5p/KIAA0101) RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay Circ_0005231 was upregulated in ESCC plasma, tissues and cells. Circ_0005231 acted as a sponge of miR-383-5p, and circ_0005231 regulated ESCC cellular behavior by sponging miR-383-5p. Moreover, miR-383-5p directly targeted KIAA0101, and circ_0005231 positively regulated KIAA0101 expression by sponging miR-383-5p. Furthermore, circ_0005231 knockdown suppressed the malignant behavior of ESCC cells by downregulating KIAA0101. Yes Cell proliferation, migration and invasion were significantly restrained by knockdown of circ_0005231 in ESCC cells. Importantly, knockdown of circ_0005231 blocked xenograft tumor growth in vivo. 35524161 hsa_circ_0007624 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell line Interaction(miR-224-5p/CPEB3/EGFR/PI3K/AKT signaling) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Here, we found that circ_0007624 was significantly underexpressed in ESCC tissues, and low expression of circ_0007624 was indicative of a poor prognosis. Mechanistically, circ_0007624 could serve as a competing endogenous RNA (ceRNA) by sponging miR-224-5p to antagonize its inhibitory effect on the target cytoplasmic polyadenylation element binding protein 3 (CPEB3). Rescue experiments showed that the anti-cancer properity role of circ_0007624 in ESCC is partly reversed by the restoration of miR-224-5p or down-regulation of CPEB3. Furthermore, EGFR/PI3K/AKT pathway was involved in the regulation of circ_0007624/miR-224-5p/CPEB3 axis in ESCC. Here, we found that circ_0007624 was significantly underexpressed in ESCC tissues, and low expression of circ_0007624 was indicative of a poor prognosis. Yes Overexpressing circ_0007624 or silencing miR-224-5p suppressed cell proliferation, metastasis, epithelial-mesenchymal transition (EMT), and promoted apoptosis in vitro. Also, circ_0007624 up-regulation slowed ESCC tumor growth in vivo. 35998761 hsa_circ_0008726 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR-206/HOXA13 pathway) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Expression of circ_0008726 was up-regulated in ESCC tissues and cells. Circ_0008726 acted as a sponge for miR-206, and HOXA13 was a target of miR-206. The suppressive effects of circ_0008726 knockdown on cell proliferation, invasion, and angiogenesis were abated by miR-206 down-regulation. Meanwhile, overexpression of HOXA13 partially reversed the suppressive effects of miR-206 enrichment on ESCC cell malignant behaviors. Knockdown of circ_0008726 inhibited ESCC tumor growth in vivo. Yes Knockdown of circ_0008726 repressed proliferation, invasion, angiogenesis, and promoted apoptosis of ESCC cells. 36190650 circRUNX1 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR-449b-5p/FOXP3 axis) In Vivo Experiment//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay CircRUNX1 was found to be significantly up-regulated in ESCC tissues and associated with TNM stage and differentiation grade.CircRUNX1 enhanced FOXP3 expression by competitively sponging miR-449b-5p. Notably, both miR-449b-5p mimics and FOXP3 knockdown restored the effects of circRUNX1 overexpression on cell proliferation and metastasis. Furthermore, IGF2BP2 binding to circRUNX1 prevented its degradation. Yes Functionally, circRUNX1 promoted ESCC cell proliferation and metastasis in vitro and in vivo. 36522683 circCYP24A1 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(PKM2/ NF-κB pathway) Wound Healing Assay//CCK8//qRT-PCR//FISH//Colony Formation Assay//Invasion Assay//Transwell Assay In this study, we identified circCYP24A1 in ESCC tissues by RNA sequencing, which is up-regulated in 114 cases of ESCC tissues and acts as a novel prognosis-related factor. Mechanistically, chemokine (C-Cmotif) ligand 5 (CCL5) is functional downstream mediator for circCYP24A1, which is screened by mRNA microarray. Moreover, circCYP24A1 physically interacts with M2 isoform of pyruvate kinase (PKM2). Rescue experiments showed that PKM2 knockdown partly reverses the promotional effects of circCYP24A1. It was revealed that circCYP24A1 increases secretion of CCL5 through the mechanism mainly by interacting with PKM2, an activator of NF-κB pathway, and thereby accelerate malignant progression of ESCC. Yes Moreover, circCYP24A1 promoted the ability of proliferation, migration, invasion and clone formation in vitro, as well as tumor growth in vivo. 36514094 circHIPK3 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(microRNA-124/AKT3) Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The results showed that the expression of circHIPK3 was considerably higher in tumor tissues from ESCC patients than that of adjacent tissues, which was associated with a poor prognosis. Mechanistically, we discovered that circHIPK3 behaved like a sponge, absorbing microRNA-124 (miR-124) and promoting serine/threonine kinase 3 (AKT3) expression. Our findings indicate that circHIPK3 acts as an oncogene in ESCC and that the circHIPK3-AKT3 axis may be a therapeutic target for patients with ESCC. The results showed that the expression of circHIPK3 was considerably higher in tumor tissues from ESCC patients than that of adjacent tissues, which was associated with a poor prognosis. Yes Additionally, silencing of circHIPK3 expression retarded esophageal cancer cell proliferation, migration and epithelial-mesenchymal transition (EMT) in vitro, as well as the growth in vivo. 35443871 hsa_circ_0001741 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR-491-5p/NOTCH3 ) RNA Pull-Down//Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//Transwell Assay We found that hsa_circ_0001741 was upregulated in ESCC tissues and was positively related to lymphatic metastasis, higher TNM stage, and poor prognosis. Mechanistically, analysis of the relationship between hsa_circ_0001741 and tumor suppressor miR-491-5p revealed that hsa_circ_0001741 functioned as a miR-491-5p sponge. Specifically, hsa_circ_0001741 bound to miR-491-5p to prevent the microRNA from binding to the 3'-UTR of NOTCH3 mRNA and suppressing NOTCH3 expression. Moreover, the ablation of hsa_circ_0001741 significantly inhibited the tumorigenicity in vivo. We found that hsa_circ_0001741 was upregulated in ESCC tissues and was positively related to lymphatic metastasis, higher TNM stage, and poor prognosis. Yes Functionally, hsa_circ_0001741 promoted ESCC cell stemness, invasion, and migration in vitro. 35693080 hsa_circ_0046264 CircRNA Homo sapiens Lung Neoplasms lung cancer tissues interaction[hsa-miR-1245] Flow Cytometry//qRT-PCR//MTT//Western Blot Hsa_circ_0046264 and BRCA2 were down-regulated in lung cancer tissues while miR-1245 was up-regulated. Overexpression of hsa_circ_0046264 could up-regulate BRCA2 expression through down-regulating of miR-1245. Yes Hsa_circ_0046264 inhibited the tumor growth in vivo. 29891014 hsa_circ_0007059 CircRNA Homo sapiens Lung Neoplasms lung cancer tissuesand the adjacent non-tumor tissues Interaction[inhibiting microRNA-378] CCK8//qRT-PCR//Western Blot Results in Fig. 1A revealed that hsa_circ_0007059 expression was clearly repressed in lung cancer tissue as contrasted to that in the adjacent tissues (P < 0.001). The investigations manifested that hsa_circ_0007059 abated cell proliferation and EMT process in lung cancer cells via inactivation of Wnt/β-catenin and ERK1/2 pathways via suppressing miR-378. Yes Overexpressed hsa_circ_0007059 evidently restrained cell proliferation, elevated p53 and repressed CyclinD1 expression, meanwhile triggered apoptosis and enhanced Bax and Cleaved-Caspase-3 expression. 31351967 circHIPK3 CircRNA Homo sapiens Lung Neoplasms lung cancer tissues and cells regulation[AKT/mTOR signaling pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay CircHIPK3 was upregulated, while miR-381-3p was downregulated in lung cancer tissues and cells. In conclusion, the silencing of circHIPK3 inhibited lung cancer progression, at least in part, by sponging miR-381-3p and inactivating the AKT/mTOR signaling pathway. Yes And circHIPK3 deficiency inhibited lung cancer progression by lowering cell proliferation, migration, glycolysis, and promoting apoptosis of lung cancer cells in vitro. 33817257 circCCS CircRNA Homo sapiens Lung Neoplasms lung cancer tissues regulation[miR-383/E2F7 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ-CCS was upregulated in lung cancer and could predict poor prognosis.Circ-CCS was shown to facilitate lung cancer progression via the miR-383/E2F7 axis, exhibiting the pivotal value of circ-CCS in diagnosis and treatment of lung cancer. Circ-CCS was upregulated in lung cancer and could predict poor prognosis. Yes Downregulation of circ-CCS inhibited lung cancer cell growth and metastasis while promoted apoptosis in vitro, and suppressed tumorigenesis of lung cancer in vivo. 33359669 circPRKCI CircRNA Homo sapiens Lung Neoplasms LCa tumor tissues and cell lines regulation[microRNA-150-5p/MECP2 axis] CCK8//qRT-PCR//Transwell Assay Circ-PRKCI level was remarkably elevated in LCa tumor tissues and cell lines.Our study shows for the first time that circ-PRKCI modulates the progression of LCa through microRNA-150-5p/MECP2 axis. At the same time, highly expressed circ-PRKCI was correlated with the poor prognosis of LCa patients. Yes In vitro cell experiments revealed that inhibition of circ-PRKCI in LCa cell lines remarkably inhibited cell invasiveness and proliferation. 33155212 hsa_circ_0001421 CircRNA Homo sapiens Lung Neoplasms LC tissues and cells regulation[miR-4677-3p/CDCA3] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Circ_0001421 was increased in LC tissues and cells,Circ_0001421 promoted cell proliferation, migration, invasion and glycolysis in LC by regulating the miR-4677-3p/CDCA3 axis, which providing a new mechanism for LC tumor progression. Yes Circ_0001421 was increased in LC tissues and cells, and knockdown of circ_0001421 repressed cell proliferation, migration, invasion and glycolysis in vitro.Meanwhile, circ_0001421 knockdown inhibited LC tumor growth in vivo. 33109222 hsa_circ_0046264 CircRNA Homo sapiens Lung Neoplasms NSCLC tissues Expression[highly expressed] Wound Healing Assay//CCK8//qRT-PCR//Microarray//Transwell Assay It was shown in the results of gene microarray assay that hsa_circ_0046264 was the most prominently upregulated gene, and RT-qPCR assay further proved that hsa_circ_0046264 expression was upregulated remarkably in the tissues of tumor patients. Clinical analysis indicated that the expression level of hsa_circ_0046264 was notably associated with the patient's age, tumor size, tumor-node-metastasis (TNM) stage, and lymph node metastasis (p<0.01). In addition, Kaplan-Meier statistical analysis manifested that the patients in hsa_circ_0046264 low-expression group had a markedly longer survival than those in hsa_circ_0046264 high-expression group. Yes According to the results of wound-healing assay, the migratory ability of A549 cells was distinctly strengthened in hsa_circ_0046264 overexpression group compared with that in the control group (p<0.05). Moreover, the transwell assay results pointed out that the invasive ability of A549 cell lines at 48 h after overexpression of hsa_circ_0046264 was evidently stronger than that in control group (p<0.05). Under the stimulation of different doses of cisplatin, hsa_circ_0046264 overexpression group had a clearly raised survival rate of A549 cells in comparison with control group, and the differences in data were statistically significant (p<0.01). 33015793 hsa_circ_010763 CircRNA Homo sapiens Lung Neoplasms NSCLC tissues and cells regulation[miR-715,c-Myc] CCK8//qRT-PCR//Luciferase Report Assay We found that both circRNA_010763 and c-Myc were upregulated in human NSCLC tissues and cells. In this study, we found that circRNA_010763 was highly expressed in human NSCLC tissues, which could promote tumor proliferation, migration and invasion through serving as a molecular sponge by modulating the inhibitory effect of miR-715 on oncogene c-Myc. Yes qRT-PCR and CCK-8 assay showed that circRNA_010763 expression is associated with the proliferation of NSCLC cells. Transwell assay showed that circRNA_010763 regulated the migration ability of NSCLC cells. 32706069 circFOXP1 CircRNA Homo sapiens Lung Neoplasms LUAD tissues and LUAD cell lines regulation[miR-185-5p/Wnt1 signaling pathway] Tunel//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay The circFOXP1 expression was increased in LUAD patients and LUAD cell lines. These data suggested that circFOXP1 promoted cell proliferation and repressed cell apoptosis in LUAD by regulating miR-185-5p/WNT1 signaling pathway. Yes The downregulation of circFOXP1 significantly repressed LUAD cell proliferation and promoted cell apoptosis. 32633368 circABCB10 CircRNA Homo sapiens Lung Neoplasms LCa tissues and cell lines regulation[microRNA-217 expression] CCK8//qRT-PCR//Luciferase Report Assay CircABCB10 showed abnormally high expression in LCa tissues and cell lines and was related to the poor prognosis of patients.Finally, cell functional experiments showed that microRNA-217 is a key downstream gene that mediates the regulation of circABCB10 on LCa cell function. CircABCB10 showed abnormally high expression in LCa tissues and cell lines and was related to the poor prognosis of patients. Yes In vitro cell experiments demonstrated that knocking down circABCB10 remarkably suppressed the proliferation and migration ability of LCa cells. 32572881 circPOLA2 CircRNA Homo sapiens Lung Neoplasms lung cancer tissues regulation[miR-326/GNB1 axis] qRT-PCR Circ_POLA2 was highly expressed in lung cancer tissues and predicted a poor prognosis in lung cancer patients.In conclusion, circ_POLA2 promotes lung cancer cell stemness and progression via regulating the miR-326/GNB1 axis, which might serve as a novel therapeutic target for lung cancer patients. Yes Knockdown of circ_POLA2 inhibited the stemness of lung cancer cells, which is evident by the decreased sphere-formation ability, ALDH1 activity, and stemness marker expression, but had no effects on cell viability. 32511866 circZFR CircRNA Homo sapiens Lung Neoplasms LC tumors regulation[circZFR/CCND1 signaling] ISH//qRT-PCR CircRNA circZFR was highly expressed in LC tumors. The possible mechanism was to regulating expression of CCND1, indicating the circZFR/CCND1 signaling might be a promising therapeutic target for LC treatment. Yes CircZFR depletion substantially decreased tumor growth compared to WT control cells. CircZFR overexpression was dramatically increased cell growth in LC cell lines. Consequently, circZFR overexpression substantially promoted tumor propagation. 35117697 circLPAR3 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR-873-5p/LDHA axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//Colony Formation Assay//EdU Staining//Transwell Assay CircLPAR3 is a stable circRNA and was increased in ESCC tissues and cells. Mechanistically, circLPAR3 served as a sponge for miR-873-5p, which targeted LDHA. Moreover, circLPAR3 could regulate LDHA expression by sponging miR-873-5p. Thereafter, rescue experiments suggested that miR-873-5p inhibition reversed the anticancer effects of circLPAR3 silencing on ESCC cells. Furthermore, miR-873-5p overexpression restrained ESCC cell Warburg effect and oncogenic phenotypes, which were abolished by LDHA up-regulation. Yes circLPAR3 knockdown suppressed ESCC cell Warburg effect, proliferation, metastasis, and induced apoptosis in vitro, and impeded xenograft tumor growth and Warburg effect in ESCC mice models. 36484173 hsa_circ_0000277 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cells and tissues Interaction(miR-873-5p/SOX4 axis ) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay Hsa_circ_0000277 expression was increased in ESCC cells and tissues, and it had important clinical significance. Hsa_circ_0000277 acted as a microRNA-873-5p (miR-873-5p) sponge and Sry-related high-mobility group box 4 (SOX4) was validated as a target of miR-873-5p. Moreover, hsa_circ_0000277/miR-873-5p axis and miR-873-5p/SOX4 axis regulated ESCC cell progression and DDP resistance. Hsa_circ_0000277/miR-873-5p axis activated SOX4/Wnt/β-catenin signaling pathway. Hsa_circ_0000277 facilitated tumorigenesis and DDP resistance by miR-873-5p/SOX4 axis in vivo. Yes Downregulation of hsa_circ_0000277 repressed ESCC cell proliferation, colony formation, cell cycle, and DDP resistance. 35241028 hsa_circ_0030998 CircRNA Homo sapiens Lung Neoplasms  lung cancer tissues  Interaction(miR-558) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In a previous study, hsa_circ_0030998 was identified as a circRNA downregulated in lung cancer, but its potential implications and mechanisms in lung cancer were not addressed. Here, we showed that overexpressing circ_0030998 decreased proliferation, migration, and invasion of lung cancer cells, while also dampening resistance to Taxol, a classical antitumor drug.  A high circ_0030998 expression was correlated with a high survival rate in lung cancer patients.  Yes  Here, we showed that overexpressing circ_0030998 decreased proliferation, migration, and invasion of lung cancer cells, while also dampening resistance to Taxol, a classical antitumor drug. Depleting circ_0030998 reversed these phenotypic effects.  33190405 hsa_circ_0003823 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR-607/CRISP3 Axis) CCK8//qRT-PCR//Western Blot Our results revealed that hsa_circ_0003823 was highly expressed in ESCC and associated with poor prognosis.In the section of mechanism experiments, hsa_circ_0003823 regulated CRISP3 by targeting microRNA-607 (miR-607) to promote progression of ESCC. Yes Further results indicated that hsa_circ_0003823 promoted proliferation and metastasis ability of ESCC. 36263172 circIMMP2L CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC patients and LNM patients Expression [highly expressed] qRT-PCR//RIP CircIMMP2L, commonly upregulated in tumor and plasma from advanced-stage ESCC patients and LNM patients, predicts poorer patient survival. CircIMMP2L was also found to be a significant indicator for LNM, even in the T1 stage of ESCC. Mechanistically, cytoplasmic circIMMP2L interacted with CtBP1 and facilitated the nuclear retention of CtBP1 in a CtBP2-independent manner. CircIMMP2L, commonly upregulated in tumor and plasma from advanced-stage ESCC patients and LNM patients, predicts poorer patient survival. Yes CircIMMP2L depletion suppressed the malignant progression of ESCC both in vitro and in vivo. 34586741 circRIMS CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma Interaction(miR-613) qRT-PCR//Western Blot//Luciferase Report Assay//FISH We found that CircRIMS was overexpressed in ESCC and predicted poor survival. In addition, miR-613 was under expressed in ESCC and inversely correlated with CircRIMS. In ESCC cells, CircRIMS overexpression decreased the expression of miR-613 and increased the methylation of miR-613 gene. We found that CircRIMS was overexpressed in ESCC and predicted poor survival. Yes Cell proliferation assay showed that CircRIMS overexpression reduced the inhibitory effects of miR-613 overexpression on cell proliferation. Animal experience finally illustrated that CircRNA CircRIMS downregulated miR-613 through methylation to promote tumor growth. 34135635 hsa_circ_0014715 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma esophageal squamous cell carcinoma tissues and cell lines Expression(highly expressed) Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay We found that circ_0014715 was highly expressed in esophageal squamous cell carcinoma tissues and cell lines. The correlation analysis of clinicopathological features and gene expression revealed that high expression of circ_0014715 was related to nerve invasion, vascular invasion, more advanced tumor-node-metastasis (TNM) stage and poor differentiation grade. Yes Experiments with cultured cells showed that knockdown of circ_0014715 significantly restrained cell proliferation, migration, invasion, wound healing and accelerated cell apoptosis. And cell cycle arrest at G2 phase was observed via flow cytometry. Overexpression of circ_0014715 caused the opposite effects. 34163248 hsa_circ_2646 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction(miR-124/PLP2 signaling pathway) CCK8//qRT-PCR//Western Blot We found that CircRNA_2646 was up-regulated in ESCC, negatively correlated with the expression of miR-124 and positively associated with TNM stage and lymph node metastasis of ESCC. Luciferase reporter assay showed that CircRNA_2646 interacted with miR-124 in ESCC Eca109 and TE-1 cells. Furthermore, it was found that the oncogene Proteolipid Protein 2 (PLP2) was the target gene of miR-124. In Eca109 and TE-1 cells, restoration of miR-124 decreased the level of PLP2 and inhibited PLP2-induced cell proliferation, migration, invasion, and EMT, but enhanced cell apoptosis. We found that CircRNA_2646 was up-regulated in ESCC, negatively correlated with the expression of miR-124 and positively associated with TNM stage and lymph node metastasis of ESCC. Yes Moreover, ectopical overexpression of CircRNA_2646 accelerated cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT), but restoration of miR-124 abrogated these functions and promoted Bcl-2-dependent cell apoptosis.The in vivo study confirmed that CircRNA_2646 promoted ESCC development by repressing miR-124 and activating PLP2. 33976115 hsa_circ_0087378 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma patients with ESCC Interaction(miR-140-3p/E2F3 Axis) CCK8//qRT-PCR//RIP//Western Blot We demonstrated that upregulated circ_0087378 expression was positively associated with tumor size, histological grade, tumor stage, the presence of metastasis, and worse survival in patients with ESCC. Mechanistically, we showed that circ_0087378 could directly bind to miR-miR-140-3p and relieve the suppression for target E2F3, which accelerated cell proliferation, migration, and invasion. Correlation analysis in ESCC specimens supported the involvement of the circ_0087378/miR-140-3p/E2F3 axis in ESCC progression. We demonstrated that upregulated circ_0087378 expression was positively associated with tumor size, histological grade, tumor stage, the presence of metastasis, and worse survival in patients with ESCC. Yes Our results further revealed that knockdown of circ_0087378 suppressed the proliferation, migration, and invasion of ESCC cells and reduced tumor growth in vivo. 33680929 circNRIP1 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR-595/SEMA4D axis and PI3K/AKT pathway) Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Expression of circ_NRIP1 was upregulated in ESCC tissues and cells. The suppressive role of circ_NRIP1 knockdown in cell growth, migration and invasion in vitro was abated by blocking miR-595; meanwhile, miR-595 overexpression elicited similar anti-tumor role in KYSE30 and KYSE450 cells, which was abrogated by restoring SEMA4D. Notably, circ_NRIP1 was a sponge for miR-595, and SEMA4D was a target of miR-595. Besides, PI3K/AKT signal was inhibited by circ_NRIP1 knockdown and/or miR-595 overexpression via indirectly or directly regulating SEMA4D. Yes Knockdown of circ_NRIP1 could enhance apoptosis rate and E-cadherin expression, but suppress colony formation, cell viability, migration, invasion, and snail expression in KYSE30 and KYSE450 cells, as well as retarded tumor growth in mice. 33957921 circDOCK5 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma Interaction(miR-627-3p/TGFB2 signaling) CCK8//qRT-PCR "Tissue microarray analysis identified circ-DOCK5 to be downregulated in ESCC tissues, and its downregulation correlated with poor prognosis. circ-DOCK5 increased the stability of miR-627-3p by functioning as a ""reservoir"" for miR-627-3p to partially reverse the ZEB1-enhanced migration and invasion in ESCC. MiR-627-3p inhibited the expression of TGFB2 and the secretion of TGF-β, which further resulted in downregulation of ZEB1 and suppression of TGF-β-induced EMT. In vivo experiments showed that ZEB1 promoted metastasis in ESCC by regulating expression of circ-DOCK5. Therefore, the present study revealed that ZEB1-mediated downregulation of circ-DOCK5 facilitates metastasis in ESCC by forming a positive feedback loop with TGF-β by altering the miR-627-3p/TGFB2 signaling." Tissue microarray analysis identified circ-DOCK5 to be downregulated in ESCC tissues, and its downregulation correlated with poor prognosis. Yes In vivo experiments showed that ZEB1 promoted metastasis in ESCC by regulating expression of circ-DOCK5. Therefore, the present study revealed that ZEB1-mediated downregulation of circ-DOCK5 facilitates metastasis in ESCC by forming a positive feedback loop with TGF-β by altering the miR-627-3p/TGFB2 signaling. 34216686 hsa_circ_0006948 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(microRNA-3612/LASP1 Axis) CCK8//qRT-PCR Circ_0006948 and LASP1 were increased, and miR-3612 was decreased in ESCC tissues and cells. Mechanically, circ_0006948 could act as a sponge of miR-3612 to regulate LASP1 expression. In addition, circ_0006948 silencing inhibited ESCC tumor growth in vivo. Yes Furthermore, circ_0006948 knockdown could suppress cell viability, colony number, migration, invasion, glycolysis, and boost apoptosis in ESCC cells. 34024023 hsa_circ_0000700 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cell lines Interaction(miR-1229) CCK8//qRT-PCR//Western Blot circ_0000700 expression was significantly upregulated in ESCC cell lines. Mechanistically, circ_0000700 was identified as a sponge of miR-1229 and could activate PRRG4, REEP5, and PSMB5 indirectly to promote ESCC progression. Yes In vitro, the proliferative and migratory capacities of ECA-109 and TE-1 cells were inhibited by knocking down circ_0000700 expression. 33854621 circDUSP16 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues, cells, Interaction(miR-497-5p/TKTL1 Axis) CCK8//qRT-PCR CircDUSP16 level was elevated in ESCC tissues, cells, and hypoxia-stimulated ESCC cells.CircDUSP16 knockdown suppressed hypoxia-induced ESCC cell growth, invasion, and glycolysis by regulating TKTL1 expression through sponging miR-497-5p. Yes Knockdown of circDUSP16 suppressed hypoxia-induced ESCC cell viability, colony formation, migration, invasion, and glycolysis. 33326930 hsa_circ_0001821 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cells Interaction(RUNX3/circ_0001821/NF-κB) Other Based on the collected data, circ_0001821 was highly expressed in ESCC cells. With regard to its mechanism, RUNX3 promoted PVT1 transcription, further upregulating circ_0001821. Moreover, circ_0001821 sponged miR-423-5p to upregulate BTRC, thus promoting IKBA ubiquitination, and circ_0001821 decreased IKBA expression to activate NF-κB signaling pathway. Yes Circ_0001821 knockdown retarded ESCC cell proliferation and tumor growth, while promoting G2-M cell cycle arrest. 35913453 circATIC CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction( miR-326/ID1 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ-ATIC was found to be upregulated in ESCC tissues and cells. Furthermore, we found that circ-ATIC could sponge miR-326, and miR-326 could target ID1. The rescue experiments revealed that miR-326 inhibitor could reverse the negative regulation of circ-ATIC silencing on ESCC progression, and ID1 overexpression also inverted the inhibitory effect of miR-326 on ESCC progression. In addition, we confirmed that the expression of ID1 was positively regulated by circ-ATIC. Yes Silenced circ-ATIC suppressed the proliferation, migration, invasion, promoted the apoptosis and oxidative stress of ESCC cells. The tumor growth of ESCC also was inhibited by circ-ATIC knockdown. 35064360 circARAP2 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Interaction(miR-761/FOXM1 axis) CCK8//qRT-PCR The result of the expression profile analyses regarding human circRNAs in ESCC demonstrated that circ-ARAP2 was up-regulated significantly in both ESCC tissues and cell lines. The data also suggested that miR-761 and FOXM1 were circ-ARAP2 downstream targets which were confirmed through luciferase reporter analysis. Yes Downregulation circ-ARAP2 suppressed ESCC proliferation, tumor growth and metastasis in both in vivo and in vitro. Overexpression of FOXM1 or inhibiting miR-761 restored ESCC cell proliferation and invasion ability after silencing circ-ARAP2. The study also found that circ-ARAP2 influenced the endothelial-mesenchymal transition (EMT) and cancer stem cells differently by regulating miR-761/FOXM1. 35842667 circAGFG1 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Interaction(miR-497-5p/SLC1A5 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Flow Cytometry//Luciferase Report Assay//Transwell Assay Circ-AGFG1 expression was upregulated in ESCC tissues and cell lines. Circ-AGFG1 acted as a sponge for miR-497-5p, and miR-497-5p interacted with the 3' untranslated region (3'UTR) of SLC1A5. miR-497-5p silencing largely abolished circ-AGFG1 silencing-induced effects in ESCC cells. miR-497-5p overexpression-mediated influences in ESCC cells were largely reversed by the addition of SLC1A5 expressing plasmid. Circ-AGFG1 could upregulate SLC1A5 expression by sponging miR-497-5p. Yes Circ-AGFG1 silencing suppressed the proliferation, migration, invasion and glutaminolysis and triggered the apoptosis of ESCC cells. Circ-AGFG1 knockdown significantly slowed down tumor growth in vivo . 36206112 circADAMTS6 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(AGR2/Hippo) Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//FISH//Colony Formation Assay//Transwell Assay We assessed circADAMTS6 expression in ESCC tissues and cells, and the relationship between circADAMTS6 expression and overall survival of ESCC patients. Induced AGR2 expression was able to rescue the loss of function induced by si-circADAMTS6 in KYSE150 cell. CircADAMTS6 may acts as oncogene by activating AGR2 and the Hippo signaling pathway coactivator YAP in ESCC. Results found that up-regulation of circADAMTS6 was associated with poor overall survival and may acted as an independent risk factor for ESCC prognosis. Yes Knockdown of circADAMTS6 significantly inhibited the proliferation, migration and invasion of ESCC cells and growth of xenograft tumors in vivo. 35962061 circFAM120B CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues and patient plasma Interaction(miR-661/PPM1L axis and the PKR/p38 MAPK/EMT pathway) RNA Pull-Down//Western Blot//Invasion Assay//Co-IP//Migration Assay//CCK8//qRT-PCR//FISH//RIP//RNA-seq//Luciferase Report Assay//Colony Formation Assay//EdU Staining We observed that circFAM120B (hsa_circ_0001666) was frequently downregulated in cancer tissues and patient plasma, and its expression level was related to overall survival in ESCC patients.Mechanistically, circFAM120B was predominantly located in the cytoplasm, guarantying its sponging for miR-661 to restore the expression of PPM1L, a tumor suppressor. We observed that circFAM120B (hsa_circ_0001666) was frequently downregulated in cancer tissues and patient plasma, and its expression level was related to overall survival in ESCC patients. Yes Overexpression of circFAM120B inhibited the proliferation, metastasis, and invasion of ESCC while silencing it enhanced malignant phenotypes. 35436983 circPUM1 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cell lines Interaction(esophageal squamous cell carcinoma) CCK8//qRT-PCR//RNA Pull-Down The expression level of circPUM1 is positively correlated with HIF1α accumulation under CoCl2-induced intracellular hypoxic-like condition in esophageal squamous cell carcinoma (ESCC) cell lines. Importantly, circPUM1 acts as a scaffold for the interaction between UQCRC1 and UQCRC2 in ESCC cell lines. Yes Knock-down of circPUM1 would result in lower intracellular oxygen concentration, downregulated oxidative phosphorylation, decrease of mitochondrial membrane potential, increase of ROS generation and shrinking of mitochondria, respectively. CircPUM1 depletion induces dysfunction of the mitochondrial complex III and the cleavage of caspase3 spontaneously. Interestingly, disruption of circPUM1 led to pyroptosis that initiates the cell death of ESCC cell lines. 35153295 hsa_circ_0003340 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR-940/PRKAA1 axis) CCK8//qRT-PCR//Western Blot Upregulated circ_0003340 and PRKAA1, and downregulated miR-940 levels were detected in ESCC.Circ_0003340 acted as a ceRNA for miR-940 in regulating ESCC progression and miR-940 was proved to target PRKAA1 to arrest ESCC progression in vitro. Yes Meanwhile, ESCC progression was apparently restrained by circ_0003340 knockdown in vitro.Finally, in vivo experiments established that silencing of circ_0003340 slowed tumor growth in vivo. 35297212 hsa_circ_0023984 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC patients and cells Interaction(miR-134-5p/cystatin-s axis) CCK8//qRT-PCR//Western Blot We found that ESCC patients with high circ_0023984 expression was associated with a poor prognosis. Circ_0023984 interacted with miR-134-5p and inhibited its activity, which promoted the expression of CST4 (Cystatin-S). Circ_0023984 also regulated tumorigenesis in a CST4-dependent manner. Together, our study indicates that the oncogenic role of Circ_0023984 is mediated by miR-134-5p/CST4 Axis in ESCC, which could serve as potential targets for future therapeutic strategies. We found that ESCC patients with high circ_0023984 expression was associated with a poor prognosis. Yes The knockdown of circ_0023984 suppressed cell growth, invasion, and migration in ESCC cells. 35440286 hsa_circ_0012673 CircRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell lines regulation[miR-320a/LIMK18521 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Circ_0012673 was overexpressed in lung cancer tissues and cell lines.Circ_0012673 was a tumor-promoter in lung cancer via acting as competing endogenous RNA to regulate LIMK1 expression by binding miR-320a. Yes Loss-of-functional experiment confirmed that knockdown of circ_0012673 constrained proliferation, motility and Epithelial-Mesenchymal Transition (EMT), but induced apoptosis by targeting miR-320a. 32141553 circZNF609 CircRNA Homo sapiens Lung Neoplasms cell lines Interaction(miR-142-3p) In Vivo Experiment//Migration Assay//CCK8//FISH//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay In current work, it was discovered that circZNF609 functioned as an onco-circRNA, which exhibited high expression as well as facilitated the proliferation and migration in LC cells. Next, we discovered that FUS RNA-binding Yes circZNF609 is oncogenic and regulates proliferation, migration, and apoptosis in LC cells. ( 33459380 circErbin CircRNA Homo sapiens Colorectal Neoplasms cell line regulation[miR-125a-5p-5p/miR-138-5p/4EBP-1 axis] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ-Erbin was highly expressed in the CRC cells and Circ-Erbin overexpression facilitated the proliferation, migration and metastasis of CRC in vitro and in vivo.Our findings uncover a key mechanism for circ-Erbin mediated HIF-1α activation by miR-125a-5p-5p/miR-138-5p/4EBP-1 axis and circ-ERBIN is a potential target for CRC treatment. Yes Circ-Erbin was highly expressed in the CRC cells and Circ-Erbin overexpression facilitated the proliferation, migration and metastasis of CRC in vitro and in vivo. 33225938 circITGA7 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation[ITGA7] qRT-PCR In this study, we demonstrated that a novel circRNA (circITGA7) and its linear host gene ITGA7 are both significantly downregulated in colorectal cancer (CRC) tissues and cell lines. Mechanistically, by using RNA-sequencing and KEGG enrichment analysis, we found that circITGA7 is a negative regulator of the Ras signalling pathway, and that ITGA7 is associated with cytokine-related signalling pathways. Yes Functional assays demonstrated that ectopic circITGA7 expression suppressed the growth and metastasis of CRC cells in vitro and in vivo. Knockdown of circITGA7 or ITGA7 promoted the proliferation and migration of CRC cells in vitro, and enhanced CRC growth in vivo. 29943828 hsa_circ_0009361 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues,cell lines Interaction[hsa_circ_0009361/miR-582/APC2] qRT-PCR//RIP//FISH n the present study, hsa_circ_0009361 was significantly Expression[down-expression]-regulated in CRC tissues and cells.Hsa_circ_0009361 was identified as the sponge of miR-582 by fluorescence in situ hybridization (FISH), RNA immunoprecipitation (RIP), and luciferase reporter assays.Overexpression of hsa_circ_0009361 Expression[Expression[up-expression]-expression]-regulated the expression of adenomatous polyposis coli 2 (APC2) and inhibited the activity of the Wnt/β-catenin pathway by competitively combining with miR-582. Exogenous miR-582 and APC2 interventions could reverse the multiple biological functions mediated by hsa_circ_0009361 in CRC cells. In vivo experiments also confirmed that hsa_circ_0009361 inhibited the growth and metastasis of CRC. Hsa_circ_0009361 acted as a tumor sExpression[Expression[up-expression]-expression]pressive sponge of miR-582, which could Expression[Expression[up-expression]-expression]-regulate the expression of APC2, inhibit the Wnt/β-catenin signaling, and sExpression[Expression[up-expression]-expression]press the growth and metastasis of CRC. Yes Low expression level of hsa_circ_0009361 promoted the proliferation, epithelial-mesenchymal transition (EMT), migration, and invasion of CRC cells. 31109967 hsa_circ_0026344 CircRNA Homo sapiens Colorectal Neoplasms cell lines (SW480 and Caco-2) Interaction[ miR-183] qRT-PCR//Western Blot//Transwell Assay CCL20 and CXCL8 synergized to facilitate the proliferation, migration and invasion of CRC cells. At the meantime, E-cadherin was downregulated, whereas N-cadherin, Vimentin and Snail were up-regulated by CCL20 and CXCL8 co-stimulation, which was accompanied by the mobilization of PI3K/AKT/ERK signalling. More interestingly, the expression of circ_0026344 was down-regulated by CCL20 and CXCL8 co-stimulation. Silence of circ_0026344 increased the migratory and invasive capacities of CRC cells and increased EMT process as well. Overexpression of circ_0026344 led to a contrary impact. miR-183 was negatively regulated by circ_0026344, and the inhibitory effects of circ_0026344 overexpression on Wnt/β-catenin pathway were reversed when miR-183 was overexpressed. Yes Silence of circ_0026344 increased the migratory and invasive capacities of CRC cells and increased EMT process as well. Overexpression of circ_0026344 led to a contrary impact. 31608699 circFMN2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation[miR-1182/hTERT signaling pathways] qRT-PCR//Luciferase Report Assay circFMN2 was found to be significantly up-regulated in CRC tissues and cell lines. Bioinformatics analysis predicted that there is a circFMN2/miR-1182/hTERT axis in CRC progression. Dual-luciferase reporter system validated the direct interaction of circFMN2, miR-1182, hTERT. Western blot verified that inhibition of circFMN2 decreased hTERT expression. Importantly, we demonstrated that circFMN2 was up-regulated in serum exosomes from CRC patients. Yes Moreover, knockdown of circFMN2 significantly inhibited cell proliferation and migration in vitro. 31738400 circVAPA CircRNA Homo sapiens Colorectal Neoplasms blood Interaction[sponging miR-101] qRT-PCR//Luciferase Report Assay//RNA-seq Using quantitative real-time polymerase chain reaction (qRT-PCR), circVAPA was found to be up-regulated in CRC patients' tissues and plasma. Luciferase reporter assay confirmed a direct interaction between circVAPA and miR-101. Furthermore, circVAPA had no effect on the expression level of miR-101, and miR-101 over-expression had the similar tumor-suppressing effects as circVAPA silencing. The tumor-promoting effect of circVAPA over-expression could be reversed by the up-regulation of miR-101. Yes Gain-of-function and loss-of-function studies in CRC cell lines indicated that circVAPA could promote CRC cell proliferation, migration, invasion, and inhibit apoptosis. 30797148 hsa_circ_0136666 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation[miR-136/SH2B1 axis] qRT-PCR In the present study, through circRNA high-throughput sequencing and quantitative real-time polymerase chain reaction, we identified that hsa_circ_0136666 was significantly overexpressed in CRC tissues and cell lines.Mechanistically, we revealed that hsa_circ_0136666 could increase SH2B1 expression via competitively binding miR-136 in CRC cells. In addition, SH2B1 overexpression could reverse the effects of hsa_circ_0136666 inhibition on CRC cell progression. In conclusion, our data suggested that hsa_circ_0136666 could promote CRC cell progression via the miR-136/SH2B1 axis, elucidating a novel approach to improve the effectiveness of CRC treatment. High hsa_circ_0136666 expression was associated with poor overall survival of patients with CRC. Yes In vitro function assays showed that hsa_circ_0136666 inhibition suppressed CRC cell proliferation, migration, invasion, and arrested CRC cells in the G0/G1 phase. Furthermore, we showed that hsa_circ_0136666 inhibition reduced CRC cell growth in vivo. 30370521 circCAMSAP1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissue Regulation[ miR-328-5p/E2F1 Axis] Western Blot//FISH//RIP//RNA-seq//IHC In this study, we determined the circRNA expression profile by next-generation RNA sequencing from eight CRC and paired non-cancerous matched tissues. circCAMSAP1 (originating from exon 2 to exon 3 of the CAMSAP1 gene, hsa_circ_0001900) was significantly upregulated in CRC tissues.Mechanism study of upstream biogenesis of circCAMSAP1 indicated that circCAMSAP1 cyclization in CRC was mediated by splicing factor epithelial-splicing regulatory protein 1. Moreover, circCAMSAP1 acted as a sponge for miR-328-5p and abrogated its suppression on transcription factor E2F1. Taken together, our data indicated an essential role of the circCAMSAP1/miR-328-5p/E2F1 axis in the progression of CRC, which implied that circCAMSAP1 could serve as a diagnostic and prognostic biomarker as well as a potential therapeutic target for CRC. Increased circCAMSAP1 expression was significantly correlated with advanced tumor/node/metastasis (TNM) stage and shortened overall survival. Yes Functionally, circCAMSAP1 promoted the malignant behavior of CRC. 31951832 hsa_circ_0079993 CircRNA Homo sapiens Colorectal Neoplasms colorectal tissue Regulation[miRNA-203a-3p.1/CREB1 axis] CCK8//qRT-PCR//Colony Formation Assay In CRC tissue POLR2J4 expression was reduced, and circ_0079993 expression was increased compared with normal tissue. Also, circ_0079993 was predicted to sponge multiple miRNAs, miR-203a-3p.1 was verified as a target of circ_0079993, and circ_0079993 indirectly regulated mRNA expression of the CREB1 gene by sponging miR-203a-3p.1 in CRC cells. The use of anti-miR-203a-3p.1 reversed the inhibitory effects of circ_0079993 knockdown on CRC cell proliferation. CONCLUSIONS The findings supported that hsa_circ_0079993 acts as an oncogene in CRC through the miRNA-203a-3p.1/CREB1 axis. Yes Knockdown of circ_0079993 significantly inhibited the proliferation of CRC cells in vitro. 31515467 hsa_circ_0002138 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] qRT-PCR In this study, we investigated the expression level of circ_0002138 in 35 paired CRC tissues by quantitative real-time polymerase chain reaction (qRT-PCR) and found that circ_0002138 was stably down-regulated in CRC tissues compared to paired adjacent normal tissues (P < 0.001). Yes Additionally, functional analysis demonstrated that circ_0002138 significantly inhibited CRC cell proliferation in vitro. 30841415 circITGA7 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Interaction[sponging miR-3187-3p and increasing ASXL1] Western Blot//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay CircRNA sequencing analysis suggested that compared to that in adjacent normal control tissue, the expression of circ-ITGA7, a novel circRNA, is decreased significantly in CRC. Yes Gain-of-function studies further demonstrated that circ-ITGA7 suppressed proliferation of CRC cells. 31372051 circNSD2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[circ-NSD2/miR-199b-5p/DDR1/JAG1 axis] qRT-PCR Circ-NSD2 expression was elevated in CRC tissues and was markedly increased in advanced stages or metastatic tumours of CRC patients. Taken together, our findings highlight a novel oncogenic function of circ-NSD2 and uncover a key mechanism for the circ-NSD2/miR-199b-5p/DDR1/JAG1 axis in CRC metastasis, which may serve as a prognostic factor and therapeutic target for antimetastatic therapy in CRC patients. Yes Gain-of-function and loss-of-function experiments demonstrated that circ-NSD2 promoted migration and metastasis of CRC in vitro and in vivo. 30666650 hsa_circ_0005075 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation[Wnt/β-catenin pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay We observed that circ_0005075 expression was significantly up-regulated in both CRC tissues and cell lines.Further mechanistic investigation showed that circ_0005075 displayed its tumor-promotive roles through activating Wnt/β-catenin pathway. Yes Cellular studies indicated that circ_0005075 can enhance the proliferation, migration, and invasion capacities of CRC cells, thereby promoting tumor progression. 31081084 hsa_circ_0021977 CircRNA Homo sapiens Colorectal Neoplasms blood Regulation[circ_0021977/miR-10b-5p/P21 and P53 regulatory axis ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Colony Formation Assay//Transwell Assay " The results showed that the patients with CRC had lower circ_0021977 expression.The results showed that the circ_0021977/miR-10b-5p/p21&p53 regulatory axis suppresses proliferation, migration, and invasion by CRC cells. " Low circ_0021977 expression in patients with CRC is associated with higher tug-lymph node metastasis (TNM) stage and poorer prognosis compared with patients with high circ_0021977 expression. Yes " The above experimental results show that circ_0021977 can inhibit the proliferation and metastasis of CRC cells in vitro.The above experimental results suggest that circ_0021977 can inhibit the proliferation of CRC cells in vivo." 31595500 hsa_circ_101555 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[miR-597-5p] Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Microarray//Cell Cycle Assay//EdU Staining//IF In this study, we evaluated the expression profile of circRNAs in 10 CRC tissues and their corresponding normal-appearing tissues (NATs) by microarray, and identified that hsa_circ_101555 (circ101555) was significantly up-regulated in tumor tissues and closely related to the prognosis of CRC patients. aken together, our results proved that circ101555 might function as a competing endogenous RNA of miR-597-5p to up-regulate CDK6 and RPA3 expression in CRC. In this study, we evaluated the expression profile of circRNAs in 10 CRC tissues and their corresponding normal-appearing tissues (NATs) by microarray, and identified that hsa_circ_101555 (circ101555) was significantly up-regulated in tumor tissues and closely related to the prognosis of CRC patients. Yes The results in vitro and in vivo showed that silencing circ101555 expression significantly suppressed cell proliferation, induced apoptosis and impaired the DNA repair capacity of CRC cells, while rescue experiments suggested that down-expression of miR-597-5p could significantly attenuate the biological effects of circ101555 knockdown on CRC cells. 31300733 hsa_circ_0053277 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction[sponging miR-2467-3p ] qRT-PCR In this study, our results showed that the expression of hsa_circ_0053277 was markedly upregulated in CRC tissues and cells. To sum up, hsa_circ_0053277 facilitated the development of CRC by sponging miR-2467-3p to upregulate MMP14 expression. Yes Knockdown of hsa_circ_0053277 inhibited cell proliferation, migration, and epithelial-mesenchymal transition (EMT) process in CRC. 31549406 hsa_circ_0104631 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Regulation[PTEN/Akt/mTOR signaling pathway ] CCK8//qRT-PCR//Colony Formation Assay//Western Blot QRT-PCR results showed that Circ-0104631 was highly expressed in tissues of patients with CRC when compared with that of normal control tissues.Circ-0104631 was highly expressed in CRC tissues. Furthermore, knockdown of Circ-0104631 could inhibit the growth and metastasis of CRC cells by regulating PTEN/Akt/mTOR signaling pathway. Yes In vitro experiment demonstrated that inhibition of Circ-0104631 in SW480 and LoVo cells could markedly decrease cell growth and metastasis abilities. 31210299 hsa_circ_000166 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[miR-326/LASP1 Axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay Then, we confirmed an upregulation of hsa_circRNA_000166 in CRC tissues and cell lines and observed that higher expression of hsa_circRNA_000166 was associated with poor 5-year survival rate of patients with CRC.Taken together, our results indicated that downregulation of hsa_circRNA_000166 inhibited the cell growth and facilitated apoptosis during CRC development by sponging the miR-326/LASP1 pathway. Then, we confirmed an upregulation of hsa_circRNA_000166 in CRC tissues and cell lines and observed that higher expression of hsa_circRNA_000166 was associated with poor 5-year survival rate of patients with CRC. Yes Next, we investigated the function of hsa_circRNA_000166 during CRC progression by knocking down its expression. Cell growth and apoptosis assay revealed that hsa_circRNA_000166 regulated the cell growth and apoptosis in CRC cell lines. 33376485 circGLG1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues interaction[circ_GLG1-miR-622-KRAS axis ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Circ_GLG1 expression was significantly higher in CRC tissues than in adjacent normal tissues. Our study revealed the role of the circ_GLG1-miR-622-KRAS axis in CRC. Yes Knocking down circ_GLG1 in DLD1 cells inhibited tumor cell viability, proliferation, invasion, and migration, and these effects were reversed by co-transfecting an miR-622 inhibitor. 33335404 hsa_circ_0000392 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[miR-193a-5p/PIK3R3/AKT axis] qRT-PCR//RNA Pull-Down CircRNA_0000392 was significantly upregulated in CRC compared with normal adjacent tissues and cell lines. CircRNA_0000392 functions as an oncogene through the miR-193a-5p/PIK3R3/Akt axis in CRC cells, suggesting that circRNA_0000392 is a potential therapeutic target for the treatment of colorectal cancer and a predictive marker for CRC patients. The expression level of circRNA_0000392 was positively correlated with the malignant progression of CRC. Yes Functional studies revealed that reducing the expression of circRNA_0000392 could inhibit the proliferation and invasion of CRC both in vitro and in vivo. 33317596 hsa_circ_100876 CircRNA Homo sapiens Colorectal Neoplasms Cc tissues and cell lines Expression[highly expressed] qRT-PCR The results of this study manifested that circRNA-100876 was abnormally overexpressed in Cc tissues and cell lines, and the high expression of circRNA-100876 was clearly associated with the Clinical stage, T classification and Lymph node metastasis of Cc patients. The results of this study manifested that circRNA-100876 was abnormally overexpressed in Cc tissues and cell lines, and the high expression of circRNA-100876 was clearly associated with the Clinical stage, T classification and Lymph node metastasis of Cc patients. Yes In addition, it was demonstrated that the inhibition of circRNA-100876 reduced the invasion ability of Cc cells. 33275225 circZNF609 CircRNA Homo sapiens Colorectal Neoplasms Colorectal Cancer Tissue Expression[Expression[lower expressed]-expression] qPCR//Western Blot CircZNF609 was significantly Expression[down-expression]-regulated in colorectal cancer tissues compared with adjacent normal tissues and in the serum of patients with colorectal cancer compared with healthy controls, verified by receiver operating characteristic (ROC) curve analysis. Expression of circZNF609 induced apoptosis and Expression[Expression[up-expression]-expression]regulated expression of the pro-apoptotic protein, Bax, Expression[down-expression]-regulated the expression of the anti-apoptotic protein, Bcl-2, and Expression[Expression[up-expression]-expression]regulated p53. Yes There was low expression of circZNF609 in HCT116 cells, and overexpression inhibited cell proliferation but had no effect on PCNA and c-Myc protein expression. 31401644 hsa_circ_100290 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation[circRNA_100290/miR-516b/FZD4/Wnt/β-catenin ] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Here, our report showed that circRNA_100290 level was significantly increased in CRC tissues and cell lines. Besides, circRNA_100290 expression was positively correlated with tumor metastasis while inversely correlated with prognosis. Yes Silencing circRNA_100290 markedly reduced cell proliferation rate, inhibited migration and invasion abilities, but promoted apoptosis in vitro. 30173892 circCPA4 CircRNA Homo sapiens Lung Neoplasms tissues and cells Interaction(miR-214-3p/TGIF2 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//Transwell Assay We determined that CircCPA4 and TGIF2 were increased, and miR-214-3p was decreased in lung cancer tissues and cells. Yes Functionally, circCPA4 knockdown could suppress colony formation, migration, invasion, cell cycle progression, and expedite apoptosis of lung cancer cells in vitro. Mechanically, circCPA4 could regulate TGIF2 expression by sponging miR-214-3p. In addition, circCPA4 deficiency inhibited the tumor growth in lung cancer in the mouse model. 34741437 hsa_circ_0010235 CircRNA Homo sapiens Lung Neoplasms lung cancer tissues and cells Interaction(miR-636/PDL1 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Circ_0010235 was overexpressed in lung cancer. MiR-636 was a target of circ_0010235, and miR-636 inhibition reversed the effects of circ_0010235 knockdown in lung cancer cells. PDL1 was a direct target of miR-636, and miR-636 suppressed the proliferation and invasion and increased apoptosis and antitumor immunity in lung cancer cells by downregulating PDL1. Moreover, circ_0010235 positively regulated PDL1 expression by sponging miR-636. Yes Circ_0010235 knockdown inhibited proliferation, invasion and immune escape and promoted apoptosis of lung cancer cells. Additionally, circ_0010235 knockdown hampered tumorigenesis in vivo. 35167195 hsa_circ_0043256 CircRNA Homo sapiens Lung Neoplasms GEO(1016 lung cancer samples and 129 matched normal samples) Expression [lower expressed] Cell Cycle Assay//IHC//EdU Staining//qRT-PCR A total of three downregulated circRNAs (hsa_circ_0043256, hsa_circ_0029426, and hsa_circ_0049271) were obtained using a Venn diagram of three datasheets. Yes In addition, functional experiment results indicated that hsa_circ_0043256 could inhibit cell proliferation and cell-cycle progression of NSCLC cells in vitro. 34806315 hsa_circ_0044516 CircRNA Homo sapiens Lung Neoplasms lung cancer tissues and cells Interaction(miR-136/MAT2A ) RNA Pull-Down//Western Blot//Bioinformatics Analysis//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Invasion Assay//Transwell Assay Recently, we observed that circ_0044516 expression levels were obviously elevated in lung cancer tissues and cells. Moreover, in vivo xenograft experiments showed that circ_0044516 downregulation reduced tumor growth. Mechanistically, in lung cancer and using bioinformatics, we demonstrated that circ_0044516 sponges miR-136 targeting MAT2A. Yes We observed that knockdown of circ_0044516 dramatically repressed cell proliferation, increased cell apoptosis, and repressed the cell cycle.Moreover, A549 and SPCA1 cell migration and invasion abilities were greatly repressed by circ_0044516 siRNA. Moreover, in vivo xenograft experiments showed that circ_0044516 downregulation reduced tumor growth. Mechanistically, in lung cancer and using bioinformatics, we demonstrated that circ_0044516 sponges miR-136 targeting MAT2A. 34258296 hsa_circ_0001320 CircRNA Homo sapiens Lung Neoplasms Sixty pairs of human lung adenocarcinoma or lung squamous cell carcinoma tissues and normal adjacent tissues Interaction(miR-558) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Further study found that circ0001320 was down-regulated in lung cancer cells, localized in the cytoplasm, and had multiple miR-558 binding sites. MiR-558 was up-regulated in lung cancer cells, and bound the downstream target genes TNFAIP1 and TPM1 to inhibit their expression. Yes After transfection with circ0001320 overexpression vector, miR-558 up-regulation or down-regulation of TNFAIP1, or TPM1 expression significantly reversed the inhibition of cell growth and invasion by circ0001320. 33128699 circMETTL15 CircRNA Homo sapiens Lung Neoplasms lung cancer tissues and cells Interaction(miR-1299/PDL1 axis) In Vivo Experiment//Western Blot//Tunel//Flow Cytometry//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay Circ-METTL15 was upregulated in lung cancer tissues and cells. Circ-METTL15 was a sponge of miR-1299, and it could exert regulatory function in lung cancer via miR-1299. Furthermore, PDL1 was a functional target of miR-1299, and miR-1299 inhibited lung cancer cell development via decreasing PDL1 expression. Yes Circ-METTL15 silencing suppressed cell proliferation, colony formation, invasion, immune escape and promoted cell apoptosis in lung cancer cells. 34796777 hsa_circ_103820 CircRNA Homo sapiens Lung Neoplasms GEO Interaction(miR-200b-3p to release LATS2 and SOCS6) qRT-PCR//RNA Pull-Down//Luciferase Report Assay//Western Blot In the present study, we identified a novel circular RNA, hsa_circ_103820, based on Gene Expression Omnibus (GEO) data. Regarding the mechanism, we revealed that miR-200b-3p was a direct target of hsa_circ_103820 and that LATS2 and SOCS6 were the downstream target genes of miR-200b-3p. Therefore, we identified a novel potential tumor suppressive function of hsa_circ_103820 in lung cancer. Yes Functionally, overexpression of hsa_circ_103820 showed significant inhibitory effects on the proliferation, migration and invasion of lung cancer cells, and knockdown of hsa_circ_103820 played promoting roles. 33589592 hsa_circ_0001073 CircRNA Homo sapiens Lung Neoplasms lung cancer cells Interaction(miR-626/LIFR axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay Results showed that circ_0001073 abundance was down-regulated in lung cancer cells.miR-626 was targeted via circ_0001073, and circ_0001073 inhibited lung cancer progression via reducing miR-626 expression. LIFR was targeted via miR-626, and miR-626 knockdown constrained cell viability and invasion and facilitated apoptosis in lung cancer cells via up-regulating LIFR. Yes circ_0001073 constrained cell viability and invasion and facilitated apoptosis in lung cancer cells. 33475233 circCD151 CircRNA Homo sapiens Lung Neoplasms human lung epithelial cells Interaction(miR‑30d‑5p/GLI2) CCK8//qRT-PCR//Transwell Assay The relative expression level of circCD151 in A549 and NCI?H292 cells was significantly higher compared with that in human lung epithelial cells. Double luciferase reporter assay confirmed the ceRNA regulatory mechanism of circCD151/miR‑30d‑5p/GLI2. Yes In A549 and NCI‑H292 cells, silencing circCD151 decreased cell activity and clonal formation ability and invasion ability was also significantly decreased. circCD151 was upregulated in A549 and NCI‑H292 cells and the activity and clonal formation ability of A549 and NCI‑H292 cells were significantly increased and the invasion ability was also significantly increased. 34368867 circPTCH1 CircRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell lines Interaction(miR-34c-5p/MYCN axis) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Our research demonstrated that the expression of circPTCH1 was upregulated in lung cancer tissues and cell lines and increased in metastatic tissues compared to that of non-metastatic tissues.circPTCH1 sponging miR-34c-5p to target MYCN was revealed by dual-luciferase reporter and a RIP assay. In addition, the expression level of miR-34c-5p was reduced in lung cancer tumor tissues, and MYCN was significantly increased in lung cancer tumor tissues.Further, cytological studies found that circPTCH1 reduced lung cancer cells' migration and invasion by targeting MYCN via miR-34c-5p. Yes Further, cytological studies found that circPTCH1 reduced lung cancer cells' migration and invasion by targeting MYCN via miR-34c-5p. 34531664 hsa_circ_0048856 CircRNA Homo sapiens Lung Neoplasms NSCLC serum and cell lines Interaction(miR-1287-5p) qRT-PCR//Western Blot//Transwell Assay Exosomes circ_0048856 was enhanced in NSCLC serum and cell lines (P < 0.001). MiR-1287-5p could be effaced by circ_0048856. MiR-1287-5p reversed the biological behavior changes of NSCLC cells which induced by circ_0048856. Exosome derived circ_0048856 had high diagnostic value for NSCLC. Yes Exosome circ_0048856 facilitated proliferation, migration and invasion, inhibited apoptosis of NSCLC cells. In vivo, exosomal circ_0048856 could significantly promote tumor growth (P < 0.001). 35228162 circERBB2 CircRNA Homo sapiens Lung Neoplasms lung cancer tissues and cells Interaction(miR-7-5p/FOXM1 axis) Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Transwell Assay Circ-ERBB2 and FOXM1 were upregulated, while miR-7-5p was decreased in lung cancer tissues and cells.Additionally, miR-7-5p directly interacted with circ-ERBB2 and FOXM1. Also, propofol played an antitumor role in lung cancer via modulating miR-7-5p or FOXM1. Yes Propofol suppressed lung cancer cell progression by regulating circ-ERBB2.Moreover, circ-ERBB2 knockdown enhanced the suppressive effect of propofol on tumor growth in vivo. 33506582 circGRHPR CircRNA Homo sapiens Lung Neoplasms NSCLC cell lines Interaction(RNA-binding protein PCBP2) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Invasion Assay//IF In this study, circ_GRHPR expression was found to be significantly upregulated in the serum of five patients with non-small cell lung cancer (NSCLC), compared to that in healthy controls. It is expressed at high levels in NSCLC cell lines, as revealed by qRT-PCR analysis. Functionally, we demonstrated that circ_GRHPR promotes NSCLC proliferation and invasion in vitro and in vivo by cell proliferation, transwell, cell cycle, and tumour-forming assays.Mechanistically, RNA pull-down and RNA immunoprecipitation assays showed that circ_GRHPR interacts with the RNA-binding protein poly(rC)-binding protein 2 (PCBP2) and regulates its subcellular localisation by forming the circ_GRHPR/PCBP2 complex, localizing PCBP2 mainly in the cytoplasm and reducing the proportion found in the nucleus. Yes Functionally, we demonstrated that circ_GRHPR promotes NSCLC proliferation and invasion in vitro and in vivo by cell proliferation, transwell, cell cycle, and tumour-forming assays. 33987874 circFAT3 CircRNA Homo sapiens Lung Neoplasms lung cancer tissues Interaction(circ-FAT3/miR-136-5p/HuR) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//IHC//Transwell Assay In the present study, we found an onctogenic circRNA in lung cancer, FAT atypical cadherin 3 (FAT3) circRNA (circ-FAT3) was remarkably upregulated in lung cancer in comparison to paired normal tissues.Overall, our data reveal the previously uncharacterized regulatory loop of circ-FAT3/miR-136-5p/HuR in lung cancer and provide novel evidence for the importance of circRNA as a ceRNA in tumorigenesis. High circ-FAT3 was closely linked to larger tumour size, lymph node metastasis, later clinical stage, as well as dismal outcome. Yes Stable knockdown of circ-FAT3 inhibited cell proliferation and metastasis both in vitro and in vivo. 34647573 circEIF3I CircRNA Homo sapiens Lung Neoplasms LC tumor tissues and cells Interaction(miR-1253/NOVA2/Wnt/β-catenin ) Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Circ-EIF3I was upregulated in LC tumor tissues and cells. Circ-EIF3I might function as an oncogene in LC, which promoted LC progression by the miR-1253/NOVA2/Wnt/β-catenin network. Yes Silenced circ-EIF3I could suppress the proliferation, migration, invasion, and enhance the apoptosis of LC cells in vitro, as well as reduce LC tumor growth in vivo. 36193788 circSATB2 CircRNA Homo sapiens Lung Neoplasms lung cancer cells Interaction(miR-330-5p/PEAK1 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay CircSATB2 interacted with microRNA-330-5p (miR-330-5p) and miR-330-5p targeted pseudopodium enriched atypical kinase 1 (PEAK1). In addition, circSATB2 affected the PEAK1 level via sponging miR-330-5p in lung cancer cells.All results suggested that exosomal transfer of circSATB2 contributed to the malignant development of lung cancer by acting as a sponge of miR-330-5p to upregulate PEAK1. Yes Exosomes enhanced cell proliferation, invasion, and migration by carrying circSATB2. Exosomal circSATB2 abrogated the inhibitory effect of short hairpin (sh)-circSATB2 on lung cancer progression. Moreover, circSATB2 promoted tumor growth in vivo via exosomes. 36148757 hsa_circ_0006692 CircRNA Homo sapiens Lung Neoplasms NSCLC specimens and cells Interaction(miR-205-5p/CDK19 Axis) Western Blot//Wound Healing Assay//CCK8//Invasion Assay//Transwell Assay Hsa_circ_0006692 was over-expressed in 60 cases of NSCLC specimens and cells, which was positively correlated with TNM stage, tumor size, and invasion of the lung basal layer. The results of the dual-luciferase reporter assay, RNA immunoprecipitation, and pull-down assays indicated that hsa_circ_0006692 sponged miR-205-5p, which targeted CDK19 and facilitated the malignant behaviors of lung cancer cells. Yes The results of the in vitro and in vivo studies revealed that the over-expression of hsa_circ_0006692 facilitated NSCLC cell growth, migration, and invasion, cell cycle arrest at the S phase, and the activation of BCL-2, CCND1, and PCNA. 35627232 circTFF1 CircRNA Homo sapiens Lung Neoplasms lung cancer cell lines Interaction( miR-29c-3p/DNMT3A Axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//ChIP CircTFF1 was found to be upregulated in lung cancer cell lines used in this study. Additionally, BCL6B exerted suppressive impacts on lung cancer cell line malignant behavior. Moreover, circTFF1 acted as the miR-29c-3p sponge to upregulate DNMT3A, which facilitated the methylation of BCL6B. In all, circTFF1 promoted proliferation, migration and invasion of lung cancer cell lines by facilitating methylation of BCL6B promoter via miR-29c-3p/DNMT3A axis. Yes Functional experiments revealed circTFF1 facilitated cell proliferation, migration and invasion. 36376550 circTAB2 CircRNA Homo sapiens Lung Neoplasms cancer tissues and cells Interaction(miR-3142/GLIS2) Western Blot//Migration Assay//Flow Cytometry//Invasion Assay//Transwell Assay CircTAB2 exhibited low expression in cancer tissues. Functional studies revealed that circTAB2 acted as a miRNA sponge, directly interacted with miR-3142 and consequently regulated GLIS2 /AKT. Yes Gain and loss-of-function assays indicated that circTAB2 could inhibit cell proliferation, migration and invasion. 36574090 circSAR1A CircRNA Homo sapiens Lung Neoplasms lung cancer samples and cells Interaction(miR-21-5p/TXNIP axis) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay circ_SAR1A and TXNIP were down-regulated while miR-21-5p was up-regulated in lung cancer samples and cells. circ_SAR1A was located predominantly in the cytoplasm; it inhibited lung cancer growth in vitro and in vivo by sponging to miR-21-5p. miR-21-5p silencing suppressed lung cancer malignancy by targeting TXNIP. Yes circ_SAR1A was located predominantly in the cytoplasm; it inhibited lung cancer growth in vitro and in vivo by sponging to miR-21-5p. miR-21-5p silencing suppressed lung cancer malignancy by targeting TXNIP. 35334496 hsa_circ_141539 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and adjacent non-cancer tissues (50 pairs) and cell lines Interaction(miR-4469) qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay The results revealed that circRNA_141539 was significantly up-regulated in patients with ESCC. The dual-luciferase reporter assay identified that circRNA_141539 directly binds to miR-4469 and also revealed that cyclin-dependent kinase-3 (CDK3) was negatively regulated by miR-4469. Furthermore, high circRNA_141539 expressions were significantly associated with TNM stage, differentiation and poor prognosis, revealing high diagnostic value (P<0.05). Yes Furthermore, circRNA_141539 overexpression promoted cell proliferation and invasion, while circRNA_141539 silencing inhibited cell proliferation and invasion (P<0.05). 33504681 circLARP4 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cell lines regulation[PTEN/PI3K/AKT Pathway] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay CircLARP4 expression was observably downregulated in ESCC cell lines, and overexpressed circLARP4 restrained cell proliferation and migration whereas boosted cell apoptosis in ESCC.CircLARP4 sponges miR-1323 and hampers tumorigenesis of ESCC through modulating PTEN/PI3K/AKT pathway. Yes CircLARP4 expression was observably downregulated in ESCC cell lines, and overexpressed circLARP4 restrained cell proliferation and migration whereas boosted cell apoptosis in ESCC. 31897898 circUBAP2 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tumour tissues regulation[microRNA-422a/Rab10 axis] qRT-PCR In the present study, circUBAP2 expression was found to be upregulated in ESCC tumour tissues.These findings suggested that circUBAP2 acted as oncogene through regulating the miR-422a/Rab10 axis in ESCC. Yes Knockdown of circUBAP2 through infection with lentiviral vector encoding shRNA targeting circUBAP2 (sh-circUBAP2) inhibited the proliferation, migration and invasion of ESCC cells. In addition, circUBAP2 significantly promoted the proliferation, migration and invasion of ESCC cells. In vivo xenograft assay demonstrated that circUBAP2 downregulation suppressed the tumour growth of ESCC. 32012318 circPLCD1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung 4 paired NSCLC and normal tissues Interaction(miR-375/miR-1179/PTEN ) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//ChIP Here, by performing circRNA high throughput sequencing in 4 paired NSCLC and normal tissues, we found a NSCLC-associated circRNA, circ-PLCD1, which was evidently downregulated in NSCLC tissues and cell lines.Mechanistically, circ-PLCD1 acted as a competitive endogenous RNA (ceRNA) to sponge miR-375 and miR-1179 and elevate PTEN, a well-known inhibitor of oncogenic PI3K/AKT signaling, thereby repressing NSCLC tumorigenesis. Yes Circ-PLCD1 was transcriptionally activated by tumor-inhibiting protein p53, and exogenous expression of circ-PLCD1 inhibited NSCLC cell proliferation, invasion and induced apoptosis. 35301686 circSEC61A1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patients Interaction(miR-513a-5p/PEX5 ) qRT-PCR//Transwell Assay Our data demonstrated that circSEC61A1 was upregulated in NSCLC patients, showing an association with poorer survival outcomes. Furthermore, circSEC61A1 could regulate PEX5 expression through competitive absorption of miR-513a-5p. Our data demonstrated that circSEC61A1 was upregulated in NSCLC patients, showing an association with poorer survival outcomes. Yes In cell experiments, circSEC61A1 overexpression promoted NSCLC malignant phenotypes, glycolysis, EMT, and Wnt/β-catenin pathway activation, whereas circSEC61A1 underexpression did the opposite. Knockdown of circSEC61A1 limited tumor growth and metastasis. 36567627 hsa_circ_0008717 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(microRNA-1287-5p/P21-activated kinase 2 (PAK2) axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0008717 was highly expressed in NSCLC. Circ_0008717 sponged miR-1287-5p to elevate PAK2, a downstream target of miR-1287-5p. Silencing of miR-1287-5p blocked the antitumor effects of circ_0008717 knockdown in NSCLC cells. Besides, miR-1287-5p repressed cell oncogenic behaviors in NSCLC by targeting PAK2. Yes Functionally, circ_0008717 deficiency suppressed cell malignant phenotypes in NSCLC in vitro and in nude mice. 35333693 hsa_circ_0003288 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues and cell lines Interaction(miR-145) In Vivo Experiment We verified that hsa_circ_0003288 expression was upregulated in lung cancer tissues and cell lines. Mechanistically, hsa_circ_0003288 negatively regulated miR-145 to exert the oncogenic role in lung cancer. Overexpression of miR-145 decreased cell proliferation, induced apoptosis, and suppressed migration and invasion in lung cancer. Yes Overexpression of hsa_circ_0003288 dramatically promoted lung cancer cell proliferation, colony formation, inhibited apoptosis, and increased cell migration and invasion in vitro. Xenograft experiments showed that hsa_circ_0003288 overexpression accelerated tumor growth in vivo. 35001875 hsa_circ_001678 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung non-small cell lung cancer (NSCLC) tissues and cells Interaction(miRNA-326/ZEB1 axis ) In Vivo Experiment//RNA Pull-Down//qRT-PCR//Luciferase Report Assay//Transwell Assay High-throughput circular RNA (circRNA) sequencing identified circRNA_001678 (circ_001678) as an upregulated circRNA in non-small cell lung cancer (NSCLC) tissues. Furthermore, circ_001678 could sponge miR-326 to up-regulate ZEB1. On the other hand, the tumor-promoting effects of circ_001678 could be inhibited by anti-PD-L1/PD-1 treatment. Mechanistically, circ_001678 led to the activation of the PD-1/PD-L1 pathway to promote CD8+ T cell apoptosis, thereby inducing NSCLC cell immune escape via regulation of the miR-326/ZEB1 axis. Yes Accordingly, we uncovered that circ_001678 over-expression augmented NSCLC progression in vitro and enhanced tumorigenicity ability in vivo. The interaction between circ_001678 and miR-326 predicted online was verified by means of luciferase and RNA pull-down assays. 35848890 hsa_circ_0004396 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-615-5p/PAK1 axis) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//RIP//Colony Formation Assay Hsa_circ_0004396 and PAK1 levels were upregulated, while miR-615-5p was declined in NSCLC. Hsa_circ_0004396 functions as a molecular sponge of miR-615-5p to regulate PAK1 expression. Moreover, hsa_circ_0004396 knockdown inhibited NSCLC tumor growth in vivo. Yes Hsa_circ_0004396 silencing inhibited NSCLC cell malignant behavior and induced radiosensitivity. Moreover, hsa_circ_0004396 knockdown inhibited NSCLC tumor growth in vivo. 35500159 hsa_circ_0000808 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cancer cells Interaction(miR-1827/SLC1A5 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ_0000808 expression was upregulated in NSCLC tissues and cancer cells, and its silencing inhibited NSCLC cell proliferation, migration, and invasion and led to apoptosis. Further results confirmed that circ_0000808 interacted with miR-1827 to positively regulate SLC1A5. Yes Circ_0000808 expression was upregulated in NSCLC tissues and cancer cells, and its silencing inhibited NSCLC cell proliferation, migration, and invasion and led to apoptosis. 36192755 circEHD2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tisssues Interaction( miR-3186-3p/FOXK1 ) qRT-PCR//Colony Formation Assay//Western Blot The results clarified in NSCLC elevated expression of circEHD2 and declined expression of microRNA (miR)-3186-3p. All in all, circEHD2 accelerates the proliferation and glycolysis of NSCLC, but refrains autophagy and apoptosis via strengthening FOXK1 via the adsorption of miR-3186-3p, which is supposed to be a latent molecular target for NSCLC therapy later. Yes Repressive circEHD2 or enhancive miR-3186-3p facilitated cell apoptosis rate and autophagy substrates LC3BII and Beclin-1, but curbed the colony-formation and DNA replication ability of NSCLC, glucose consumption, lactic acid production, glycolytic rate-limiting enzyme HK-2 and glutamine hydrolase GLS1 and P62, while overexpressed circEHD2 was adverse. 35220908 circDLG1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-630/CENPF axis) qRT-PCR//Transwell Assay//Western Blot CircDLG1 and CENPF were highly expressed in NSCLC, while miR-630 was downregulated.Mechanistically, circDLG1 deficiency modulated NSCLC cell malignant development through interacting with miR-630. Furthermore, CENPF was targeted by miR-630, and circDLG1 could positively control CENPF expression through acting as an miR-630 sponge. Yes CircDLG1 silencing repressed proliferation, migration, and invasion, and expedited apoptosis of NSCLC cells in vitro. 35748916 hsa_circ_0000514 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-330-5p and HMGA2) Western Blot//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Circ_0000514 expression was up-regulated in NSCLC tissues. Circ_0000514 was identified as a molecular sponge to decoy miR-330-5p, and HMGA2 was proven to be a target gene of miR-330-5p. Moreover, circ_0000514 positively regulated HMGA2 expression, and its biological effect was dependent on miR-330-5p/HMGA2 axis. Yes Circ_0000514 significantly facilitated the growth, cell cycle progression, metastatic potential, and repressed the apoptosis of NSCLC cells. 35552087 circTADA2A CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues, A549 and H1299 cells Interaction(miR-450b-3p/HMGN5 ) qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Western Blot CircTADA2A expression was significantly upregulated and correlated with poor overall survival of NSCLC patients. circTADA2A functioned as a competing endogenous RNA to sponge miR-450b-3p to promote the expression of HMGN5 mRNA and protein. Furthermore, a positive relationship between circTADA2A and HMGN5 existed in NSCLC tissues. There were negative relationships between circTADA2A and miR-450b-3p as well as miR-450b-3p and HMGN5 in NSCLC tissues. CircTADA2A expression was significantly upregulated and correlated with poor overall survival of NSCLC patients. Yes Functionally, circTADA2A inhibition successfully suppressed the proliferation, invasion, and migration of A549 and H1299 cells. 35261900 circHSP90A CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Regulation(STAT3/PD-1/PD-L1 ) Wound Healing Assay//CCK8//qRT-PCR//RIP//Colony Formation Assay Results depicted that circ-HSP90A was cyclization from its host gene heat shock protein 90 alpha (HSP90A) and was up-regulated in NSCLC cells. Mechanistically, circ-HSP90A recruited ubiquitin specific peptidase 30 (USP30) to stabilize HSP90A and then stimulated the signal transducer and activator of transcription 3 (STAT3) signaling. Meanwhile, circ-HSP90A sponged miR-424-5p to programmed cell death ligand 1 (PD-L1). Yes Circ-HSP90A depletion retarded proliferation, migration, invasion, and immune evasion. 35750765 hsa_circ_0075048 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-1225-5p/HMGB2) qRT-PCR//Western Blot//Transwell Assay Circ_0075048 was increased in NSCLC tissues and cells. Downregulation of miR-1225-5p recuperated the effects of circ_0075048 knockdown on NSCLC progression. The effects of miR-1225-5p on cell proliferation, apoptosis, migration, invasion and sphere formation were attenuated by HMGB2 overexpression. Yes NSCLC cell proliferation, migration, invasion and sphere formation ability were decreased by circ_0075048 knockdown, and cell apoptosis was induced. 36416408 circFARSA CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-15a-5p/B7H3 ) CCK8//qRT-PCR//FISH//RIP//Transwell Assay The present study demonstrated that circFARSA was upregulated in NSCLC tissues and cell lines, and its expression was positively correlated with poor prognosis of patients with NSCLC.Mechanistically, circFARSA facilitated the malignant phenotype of NSCLC cells by enhancing B7H3 expression through sponging miR-15a-5p. Yes Further experiments revealed that circFARSA knockdown inhibited cell proliferation, migration, and invasion in vitro experiments, but overexpression of circFARSA exhibited opposite results. 35920698 circATXN7 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-7-5p/PFN2) Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay CircATXN7 and PFN2 were highly expressed in NSCLC, whereas miR-7-5p expression had the opposite trend.CircATXN7 served as a miR-7-5p sponge, and circATXN7 regulated malignant behaviors of NSCLC cells through sponging miR-7-5p. PFN2 acted as a miR-7-5p target. PFN2 silencing overturned the promoting effect of miR-7-5p inhibitor on NSCLC cell malignancy, while PFN2 overexpression reversed the inhibitory impact of miR-7-5p mimic on NSCLC cell malignancy. Yes CircATXN7 overexpression constrained apoptosis and promoted proliferation, metastasis, invasion, and epithelial-mesenchymal transition of NSCLC cells, but circATXN7 silencing played the opposing influence and repressed xenograft tumor growth in vivo. 35445786 circMIIP CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-766-5p/FAM83A ) Wound Healing Assay//CCK8//qRT-PCR//IHC//Bioinformatics Analysis//Transwell Assay CircMIIP was highly expressed in NSCLC tissues and cell lines. CircMIIP acted as a molecular sponge for miR-766-5p, and circMIIP silencing-mediated anti-tumor effects were largely overturned by the knockdown of miR-766-5p in NSCLC cells. miR-766-5p interacted with the 3' untranslated region (3'UTR) of FAM83A, and FAM83A overexpression largely reversed miR-766-5p accumulation-induced anti-tumor effects in NSCLC cells. CircMIIP competitively bound to miR-766-5p to elevate the expression of FAM83A in NSCLC cells. Yes CircMIIP knockdown restrained the proliferation, migration and invasion and induced the apoptosis of NSCLC cells. CircMIIP knockdown significantly restrained xenograft tumor growth in vivo. 35013754 circBIRC6 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-217/APPBP2 ) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay CircBIRC6 was overexpressed in NSCLC tissues and cells. Mechanically, circBIRC6 functioned as miR-217 sponge to promote APPBP2 expression in NSCLC cells. MiR-217 inhibition rescued circBIRC6 knockdown-mediated effects on NSCLC cell colony formation, metastasis, and apoptosis. Overexpression of miR-217 inhibited the malignant phenotypes of NSCLC cells, while the effects were abrogated by elevating APPBP2. Yes Knockdown of circBIRC6 repressed the colony formation and metastasis and facilitated apoptosis of NSCLC cells in vitro and restrained tumorigenesis in vivo. 35191420 hsa_circ_0020123 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC samples and cells Interaction(miR-193a-3p/IRF4) qRT-PCR//RNA Pull-Down//Western Blot We observed an overt elevation in circ_0020123 expression in NSCLC samples and cells, and NSCLC patients with high circ_0020123 expression had a poor prognosis. Circ_0020123 could absorb miR-193a-3p to regulate IRF4 expression. miR-193a-3p silencing overturned circ_0020123 knockdown-mediated impacts on NSCLC cell malignancy, autophagy, and glycolysis. And IRF4 overexpression reversed miR-193a-3p mimic-mediated effects on NSCLC cell malignancy, autophagy, and glycolysis. Circ_0020123 promoted glycolysis and tumor growth by upregulating IRF4 through sequestering miR-193a-3p in NSCLC, offering a novel mechanism by which circ_0020123 is responsible for the malignancy, autophagy, and glycolysis of NSCLC cells. We observed an overt elevation in circ_0020123 expression in NSCLC samples and cells, and NSCLC patients with high circ_0020123 expression had a poor prognosis. Yes Circ_0020123 knockdown constrained xenograft tumor growth in vivo and curbed cell proliferation, migration, and glycolysis, and accelerated cell apoptosis and autophagy in NSCLC cells in vitro. 35225648 hsa_circ_0018189 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells and samples Interaction(miR-656-3p/xCT) qRT-PCR//Luciferase Report Assay//Western Blot Hsa_circ_0018189 abundance was overexpressed in NSCLC cells and samples. Hsa_circ_0018189 could up-regulate xCT by sponging miR-656-3p. And miR-656-3p downregulation or xCT overexpression partly overturned hsa_circ_0018189 knockdown or miR-656-3p mimic-mediated repression of NSCLC cell malignancy. Yes Deficiency of hsa_circ_0018189 lowered NSCLC cell proliferative, migrating, invading, and glutamine metabolism capacities, and hsa_circ_0018189 silencing inhibited the growth of tumors in vivo. 36164726 hsa_circ_0016760 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-4295/E2F3 axis,) qRT-PCR//Luciferase Report Assay//Western Blot Circ_0016760 and E2F3 expression levels were upregulated in NSCLC tissues and cells, while miR-4295 was downregulated. Circ_0016760 could bind to miR-4295, and negatively modulate its expression in NSCLC cells. Besides, miR-4295 directly targeted E2F3 and inversely regulated E2F3 expression. Yes More importantly, Circ_0016760 facilitated proliferation and glycolysis of NSCLC cells by increasing E2F3 by sponging miR-4295 as well as promoted the tumor growth in vivo. 33232618 hsa_circ_0000317 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction( miR-494-3p/PTEN/PI3K/AKT pathway) RNA Pull-Down//Western Blot//qRT-PCR//RIP//FISH//MTT//Luciferase Report Assay Circ_0000317 expression level was reduced in NSCLC tissues and cell lines. In addition, circ_0000317, was identified as a competitive endogenous RNA, which could sponge miR-494-3p to increase PTEN expression and activate PI3K/AKT pathway. Circ_0000317 expression in NSCLC patients was associated with TNM stage and lymphatic metastasis. Yes Circ_0000317 overexpression restrained the proliferation, migration, and invasion of NSCLC cells, but co-transfection of miR-494-3p mimics partially reversed this effect. 35917658 hsa_circ_0070659 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissues and cells Interaction(miR-377/RAB3C axis) RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Transwell Assay Our experimental results showed that circ_0070659 levels were largely increased in tumor tissues and cells. Our study revealed a novel signaling pathway that circ_0070659/miR-377/RAB3C axis regulates tumor progression, and it may become a new therapeutic target for NSCLC. Yes Biologically, knockdown of circ_0070659 obviously inhibited proliferation, migration, and invasion of NSCLC cells. 36694911 circCNOT6L CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues/cells regulation[miR-384/FN1 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay CircCNOT6L and FN1 levels were upregulated, and miR-384 level was downregulated in ESCC tissues/cells. Our results demonstrated that circCNOT6L positively regulated the development of ESCC cells via modulating miR-384/FN1 axis. Yes CircCNOT6L knockdown attenuated ESCC cell proliferation and iron metabolism disorder, as well as accelerated apoptosis. 32329843 circZCCHC6 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC serum, tissues, and cells Interaction(miR-433-3p/LPCAT1) RNA Pull-Down//Northern Blot//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay CircZCCHC6 was highly expressed in NSCLC serum, tissues, and cells. The mechanical analysis suggested that circZCCHC6 acted as a sponge of miR-433-3p to regulate LPCAT1 expression.CircZCCHC6 inhibited the progression of NSCLC cells partly by regulating the miR-433-3p/LPCAT1 axis, implying a promising therapeutic target for the NSCLC treatment. Yes Moreover, circZCCHC6 knockdown could repress cell viability, cell cycle progression, migration, invasion, and EMT in NSCLC cells in vitro. . CircZCCHC6 silencing hindered cell growth and EMT of NSCLC in vivo. 35089454 hsa_circ_0010235 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-433-3p/TIPRL axis) Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Colony Formation Assay//Transwell Assay Hsa_circ_0010235 and TIPRL were highly expressed in NSCLC tissues and cells, while miR-433-3p was downregulated. Hsa_circ_0010235 sponged miR-433-3p to upregulate TIPRL expression, so as to affect NSCLC development. Hsa_circ_0010235 knockdown also blocked tumor growth in vivo. Yes Depletion of hsa_circ_0010235 or gain of miR-433-3p repressed proliferation and autophagy but promoted apoptosis in NSCLC cells. 33494763 hsa_circ_0015278 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(microRNA 1278/SOCS6 gene axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//IHC//Transwell Assay Circ_0015278 was downregulated in NSCLC tissues and cells, and its reduced expression indicated poor prognosis. Mechanically, circ_0015278 acted as an miR-1278 sponge to reduce its quantity, and miR-1278 targeted SOCS6 to inhibit its expression in NSCLC cells. Circ_0015278 promoted SOCS6 expression by sponging miR-1,278 in NSCLC cells. Overexpression of circ_0015278 attenuated the malignant phenotypes of NSCLC through sponging miR-1278 and consequently promoting SOCS6 expression. Circ_0015278 was downregulated in NSCLC tissues and cells, and its reduced expression indicated poor prognosis. Yes Overexpression of circ_0015278 restrained the proliferation, colony formation, invasion, and epithelial-mesenchymal transition (EMT) of NSCLC cells and induced NSCLC cell apoptosis. Moreover, overexpression of circ_0015278 inhibited the growth of NSCLC in vivo. 34532392 circPUM1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines. Interaction(miR-590-5p/METTL3 axis) RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay CircPUM1 was highly expressed in NSCLC tissues and cell lines.Moreover, circPUM1 directly bound to miR-590-5p, and miR-590-5p inhibitor reversed the inhibitory effects of circPUM1 knockdown on NSCLC carcinogenesis. Additionally, miR-590-5p suppressed NSCLC progression by directly targeting and regulating METTL3. Yes CircPUM1 knockdown suppressed cell proliferation, cell cycle and glycolysis in vitro. In addition, it was also proved circPUM1 silencing impeded tumor growth and glycolysis in the murine xenograft model by regulating miR-590-5p/METTL3 axis. 34097560 circUBAP2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Clinical samples and NSCLC cell lines Interaction(miR3182-KLF4 ) CCK8//qRT-PCR//Luciferase Report Assay//Western Blot circUBAP2 exhibited significantly elevated average level in our clinical samples of NSCLC, compared with normal tissues.Further experiments indicated that circUBAP2 promoted malignant biological behavior of NSCLC tumor cells by targeting KLF4 through modulating miR-3182 expression. CircUBAP2 level was positively correlated with disease stage and metastatic status. Yes circUBAP2 significantly enhanced the migration, proliferation and chemo-resistance of NSCLC cell lines. 33882454 circMMP11 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-143 ) CCK8//qRT-PCR We found that circMMP11 was overexpressed in NSCLC and predicted patients' poor survival.Moreover, a close correlation between circMMP11 and miR143 was observed. In NSCLC cells, circMMP11 overexpression reduced miR-143 expression and increased miR-143 methylation. We found that circMMP11 was overexpressed in NSCLC and predicted patients' poor survival. Yes CCK-8 assay analysis showed that miR-143 reversed the enhancing effects of circMMP11 overexpression on cell proliferation. 34749774 hsa_circ_0006988 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-491-5p/MAP3K3 axis) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//IHC Circ_0006988 abundance was increased in NSCLC tissues and cells. Circ_0006988 sponged miR-491-5p, which directly targeted MAP3K3. MiR-491-5p overexpression repressed NSCLC cell malignant behaviors. Yes Circ_0006988 silencing restrained NSCLC cell proliferation, migration, invasion and angiogenesis, and induced apoptosis. MiR-491-5p downregulation or MAP3K3 overexpression reversed the effect of circ_0006988 silencing on NSCLC cell progression. In addition, circ_0006988 knockdown reduced xenograft tumor growth. 34189997 hsa_circ_0001947 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(MiR-661/DOK7 Axis ) CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay Circ_0001947 was low-expressed in NSCLC tissues and cells. MiR-661 was a target gene of circ_0001947 that participated in the regulation of circ_0001947 on cell biological behaviors. Furthermore, DOK7, the target gene of miR-661, partly participated in the regulation of miR-661 on cell viability. Yes Circ_0001947 knockdown intensified cell viability and proliferation, induced cell cycle arrest at S phase, suppressed apoptosis and evidently enhanced miR-510, miR-587, miR-661 and miR-942 levels, while circ_0001947 overexpression did the opposite. 34528912 circZNF124 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-498/YES1 axis) qRT-PCR//Western Blot//Transwell Assay As results, we found that the expression of circ-ZNF124 was elevated in NSCLC tissues and cells. In conclusion, these findings supported that circ-ZNF124 regulated the expression of YES1 by acting as a sponge of miR-498, thus restraining NSCLC development by inactivating the Wnt/β-catenin signaling pathway, which provided a novel strategy to treat NSCLC. Yes Functionally, circ-ZNF124 downregulation inhibited NSCLC cell proliferation and invasion but induced apoptosis and cycle arrest in vitro, and blocked tumor growth in vivo by animal experiments. 33186139 hsa_circ_0074027 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(microRNA-362-3p/clathrin heavy chain axis) Transwell Assay//qRT-PCR//Colony Formation Assay//Western Blot We found that The enrichment of circ_0074027 and CLTC protein was elevated, and a significant reduction in the expression of miR-362-3p was observed in NSCLC tissues and cells relative to adjacent normal tissues and human bronchial epithelial cells 16HBE.Circ_0074027/miR-362-3p/CLTC axis was first found to regulate the malignance of NSCLC cells. Yes Circ_0074027 and CLTC could accelerate the colony formation and metastasis and suppress the apoptosis of NSCLC cells.Circ_0074027 acted as an oncogene to promote the growth of NSCLC tumors in vivo. 32932275 hsa_circ_0001806 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-1182/NOVA2 Axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Circ_0001806 expression in NSCLC tissues and cell lines was substantially augmented, while miR-1182 expression was markedly decreased. Circ_0001806 indirectly enhanced NOVA2 expression by specifically down-modulating miR-1182. Yes Circ_0001806 facilitated the multiplication, migration and invasion of H1650 and HCC827 cells, while miR-1182 exerted the opposite effect. 33854376 hsa_circ_0000517 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-326/miR-330-5p) qRT-PCR//Western Blot//RNA Pull-Down//Transwell Assay Circ_0000517 was shown to be up-regulated in NSCLC tissues and cell lines. Mechanistically, circ_0000517 was demonstrated to up-regulate MMP2 expression via decoying miR-326 and miR-330-5p to facilitate the malignant biological behaviors of NSCLC cells. The up-regulation of circ_0000517 is closely associated with advanced clinical stage of cancer, lymph node metastasis, and poor prognosis in NSCLC patients. Yes Circ_0000517 knockdown impeded the proliferation, migration, and invasion of NSCLC cells and enhanced their apoptosis. 34837683 hsa_circ_0060937 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-195-5p/HMGB3 pathway) qRT-PCR//RNA Pull-Down//Luciferase Report Assay//Transwell Assay .Circ_0060937 and HMGB3 levels were elevated, whereas miR-195-5p level was dropped in NSCLC. Knockdown of circ_0060937 restrained NSCLC development via absorbing miR-195-5p. Circ_0060937 silencing inhibited NSCLC progression by mediating HMGB3. Yes Circ_0060937 down-regulation restrainedNSCLC cell proliferation, migration, invasion and glycolysis, and triggered apoptosis.Besides, circ_0060937 depletion suppressed tumor growth in vivo. 34470585 circVAPA CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tissues and cell lines of NSCLC Interaction(miR-876-5p/WNT5A axis) qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Our findings demonstrated high expression of circVAPA in tissues and cell lines of NSCLC.Mechanistically, circVAPA acted as a competing endogenous RNA to up-regulate WNT5A by sponging miR-876-5p. Moreover, circVAPA activated Wnt/β-catenin signaling by up-regulation of WNT5A. Yes Knockdown of circVAPA had a suppressive effect on cell proliferation, migration, invasion and stemness, and also inhibited tumor growth in vivo 33619796 circPGC CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-532-3p/FOXR2 network.) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The results showed that circ-PGC and FOXR2 were upregulated in NSCLC tissues and cells. In conclusion, circ-PGC positively regulated FOXR2 expression by competitively binding to miR-532-3p, thereby promoting the development of NSCLC, and the Wnt/β-catenin signaling pathway might be activated by the circ-PGC/miR-532-3p/FOXR2 network.miR-532-3p/FOXR2 network. Yes Circ-PGC knockdown or FOXR2 knockdown inhibited NSCLC cell viability, colony formation, cell migration, invasion and glycolysis metabolism, and FOXR2 overexpression rescued these inhibitory effects caused by circ-PGC knockdown. 34494941 hsa_circ_0000376 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-488-3p/BRD4 axis and the PI3K/PKB signaling pathway) Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0000376 was highly expressed in NSCLC tissues and cells. Circ_0000376 downregulation inhibited NSCLC cell proliferation, invasion and migration, promoted cell apoptosis and cell cycle arrest and slowed tumor growth in vivo. Circ_0000376 competitively bound to miR-488-3p to regulate the expression of BRD4. Rescue experiments showed that miR-488-3p deficiency reversed the effects of circ_0000376 downregulation, and miR-488-3p restoration-suppressed cell proliferation, migration and invasion were recovered by BRD4 overexpression. Moreover, circ_0000376 downregulation weakened the levels of phosphorylated PI3K and PKB, thus reducing the activity of the PI3K/PKB pathway. Yes Rescue experiments showed that miR-488-3p deficiency reversed the effects of circ_0000376 downregulation, and miR-488-3p restoration-suppressed cell proliferation, migration and invasion were recovered by BRD4 overexpression. 34730838 hsa_circ_0020123 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-384/TRIM44 Axis) qRT-PCR//RNA Pull-Down//Luciferase Report Assay//Western Blot Levels of circ_0020123 and TRIM44 were enhanced, and the miR-384 level was attenuated in NSCLC tissues and cells.Besides, circ_0020123 interacted with miR-384, and miR-384 targeted TRIM44. Circ_0020123 regulated cell progression by regulating miR-384 and subsequently mediated TRIM44 expression. Yes Circ_0020123 depletion attenuated the abilities of NSCLC cell viability, migration, invasion, and epithelial-mesenchymal transition (EMT), and induced apoptosis. Besides, circ_0020123 depletion repressed tumor growth in vivo. 33442296 hsa_circ_0102231 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Interaction(miR-145/RBBP4 axis ) qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Western Blot We found that hsa_circ_0102231 level was higher in NSCLC cells. hsa_circ_0102231 is mainly localized to the cytoplasm.hsa_circ_0102231 promotes NSCLC cell proliferation and invasion by sponge for miR-145.miR-145 significantly decreases the RBBP4 promoter activity, and its mRNA and protein levels. RBBP4 is an oncogene to promote proliferation and invasion ability. Yes hsa_circ_0102231 promotes NSCLC cell proliferation and invasion by sponge for miR-145. 33084863 circRHOT1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer cell lines and clinical tumor tissues Regulation(KAT5/c-MYC) Western Blot//qRT-PCR//FISH//RIP//MTT//ChIP We found that circRHOT1 were elevated in the clinical tumor tissues relative to that in the peritumor tissues from NSCLC patients.circRHOT1 was up-regulated in human lung cancer cell lines compared with normal human lung epithelial cell line.. In summary, we concluded that circRHOT1 contributed to pathogenesis of NSCLC by epigenetically enhancing c-MYC expression through recruiting KAT5. Yes MTT assays revealed that the silencing of circRHOT1 by siRNA suppressed cell viabilities of NSCLC cells. Colony formation and Edu assays confirmed that circRHOT1 knockdown attenuated NSCLC cell proliferation in vitro. 34406978 circSCAP CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues Interaction(SF3A3/MDM4-S/p53 ) RNA Pull-Down//Wound Healing Assay//qRT-PCR//RIP//FISH//IP//Transwell Assay We screened the expression profiles of human circRNAs in lung cancer tissues and found that hsa_circ_0065214 (termed as circSCAP) was significantly decreased. Mechanistically, circSCAP directly binds to the SF3A3 protein, facilitating the reduction of SF3A3 by promoting its ubiquitin-proteasome-mediated degradation, which enhances the expression of MDM4-S to finally activate its downstream p53 signaling. Kaplan-Meier analysis showed that patients with low level of circSCAP had a significantly poor prognosis. Yes Gain- and loss-of-function experiments suggested that circSCAP played an important role in NSCLC cell proliferation, cell migration and apoptosis. 35365208 hsa_circ_0020123 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-512-3p/CORO1C) CCK8//qRT-PCR//RIP//Western Blot Circ_0020123 expression was aberrantly upregulated in NSCLC tissues and cell lines.Circ_0020123 acted as a molecular sponge for miR-512-3p. Circ_0020123 silencing-induced effects in NSCLC cells were largely reversed by the knockdown of miR-512-3p. miR-512-3p interacted with the 3' untranslated region (3'UTR) of CORO1C. CORO1C overexpression largely reversed miR-512-3p accumulation-induced influences in NSCLC cells. Circ_0020123 positively regulated CORO1C expression by sponging miR-512-3p in NSCLC cells. Yes Circ_0020123 interference markedly restrained cell proliferation, migration, invasion, angiogenesis and autophagy and induced cell apoptosis of NSCLC cells. Circ_0020123 knockdown suppressed xenograft tumor growth in vivo. 35388975 hsa_circ_0120376 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-148b-3p/CEP55 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that circ_0120376 was markedly overexpressed in NSCLC, and its overexpression was positively associated with increased T stage and lymph node metastasis of the patients. Circ_0120376 could adsorb miR-148b-3p to reduce miR-148b-3p expression, and circ_0120376 could increase CEP55 expression via adsorbing miR-148b-3p. We found that circ_0120376 was markedly overexpressed in NSCLC, and its overexpression was positively associated with increased T stage and lymph node metastasis of the patients. Yes Functional experiments unveiled that circ_0120376 enhanced the proliferation, migration and invasion of NSCLC cells and impeded apoptosis, while knocking down circ_0120376 remarkably suppressed the malignant features of NSCLC cells mentioned above. 35549631 hsa_circ_0001955 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction( miR-769-5p/EGFR axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//BrdU//Transwell Assay Circ_0001955 expression was up-regulated in NSCLC tissues and cell lines, and its overexpression was strongly associated with increased tumor TNM stage and lymph node metastasis. Circ_0001955 directly targeted miR-769-5p and negatively regulated its expression. EGFR, a target gene of miR-769-5p, could be indirectly and positively regulated by circ_0001955. Correlation analysis indicated that circ_0001955 was negatively correlated with miR-769-5p expression, while circ_0001955 was positively correlated with EGFR expression. Circ_0001955 facilitates the proliferation and represses the apoptosis of NSCLC cells by modulating miR-769-5p/EGFR axis. Circ_0001955 expression was up-regulated in NSCLC tissues and cell lines, and its overexpression was strongly associated with increased tumor TNM stage and lymph node metastasis. Yes Circ_0001955 overexpression enhanced the proliferation and restrained the apoptosis in NSCLC cells, whereas knocking down circ_0001955 exerted the opposite effects. 35920610 hsa_circ_0079530 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell line Interaction(miR-584-5p/THBS2) qRT-PCR//Western Blot Circ_0079530 was highly expressed in NSCLC tissues and cell lines. Circ_0079530 silence showed the opposite effects on the above malignant biological behaviors. Mechanistic analysis showed that circ_0079530 functioned as a sponge of miR-584-5p to relieve the suppressive action of miR-584-5p on its target THBS2. Yes Circ_0079530 overexpression facilitated proliferation, migration, and invasion whereas it restrained the apoptosis of NSCLC cells.Additionally, circ_0079530 knockdown impeded the growth of xenografts in vivo. 36382967 hsa_circ_0079530 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(Hsa_circ_0079530/AQP4 Axis ) CCK8//qRT-PCR//Western Blot Circ_0079530 expression was increased in NSCLC tissues and radioresistant samples. Circ_0079530 was verified as a miR-409-3p sponge, and miR-409-3p downregulation mitigated the effects of circ_0079530 interference on NSCLC cell malignancy and radiosensitivity. AQP4 was directly targeted by miR-409-3p. MiR-409-3p restrained cell proliferation, migration, and invasion, and enhanced radiosensitivity by decreasing AQP4 expression. Notably, circ_0079530 silence decreased AQP4 expression by regulating miR-409-3p expression. Yes Circ_0079530 knockdown restrained cell proliferation, migration, and invasion, and facilitated radiosensitivity. Circ_0079530 silence decreased tumor growth with or without radiation treatment. 35896371 circFAM126A CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-613/IRS2) CCK8//qRT-PCR//Western Blot CircFAM126A was obviously overexpressed in NSCLC tissues and cells when compared with controls. In addition, IRS2 was a target gene of miR-613. Overexpression of miR-613 exerted carcinoma inhibitor role in NSCLC by inhibition of IRS2 expression.Mechanistically, circFAM126A could function as a miRNA sponge for miR-613 to regulate the expression of IRS2, thereby regulating proliferation, migration, invasion, apoptosis, and cell cycle arrest in NSCLC cells. Yes The loss-of-functional experiments suggested that knockdown of circFAM126A suppressed proliferation, migration and invasion, as well as caused apoptosis and cell cycle arrest in NSCLC cells, which was abolished by silencing of miR-613. Consistently, the silencing of circFAM126A also functioned anti-tumorigenic roles in nude mice in vivo. 35397054 hsa_circ_0006006 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-924/SRSF7 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining Circ_0006006 was increased in NSCLC tissues and cells. Follow-up mechanism experiments depicted that circ_0006006 sponged miR-924 and miR-924 inhibitor rescued the circ_0006006 knockdown-mediated inhibition effect on the progression of NSCLC. Additionally, the inhibition effect of circ_0006006 knockdown on SRSF7 expression was reversed by miR-924 inhibitor. Moreover, the suppressive effect of miR-924 on NSCLC progression was reversed by SRSF7 overexpression. Yes Loss-of-function assays demonstrated that circ_0006006 silencing repressed proliferative ability, cell migration and invasion, and angiogenesis, as well as promoted cell apoptosis, in A549 and H1299 cells. Xenograft tumor experiment unveiled that circ_0006006 knockdown inhibited tumor growth in vivo. 35037349 circENTPD7 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and paired non-tumor tissues Expression(highly expressed) CCK8//qRT-PCR//ELISA//Western Blot CircENTPD7 was upregulated in NSCLC and high expression levels of circENTPD7 predicts the poor survival rate of NSCLC cells. In NSCLC tissues, circENTPD7 was inversely correlated with PTEN protein but not mRNA. In NSCLC tissues, overexpression of circENTPD7 resulted in downregulation of PTEN, but did not alter the expression of PTEN mRNA. Cell proliferation analysis showed that overexpression of circENTPD7 promoted the proliferation of NSCLC cells and reduced the inhibitory effects of overexpression of PTEN on cell proliferation. CircENTPD7 may suppress the accumulation of PTEN to promote cell proliferation in NSCLC. CircENTPD7 was upregulated in NSCLC and high expression levels of circENTPD7 predicts the poor survival rate of NSCLC cells. Yes In NSCLC tissues, overexpression of circENTPD7 resulted in downregulation of PTEN, but did not alter the expression of PTEN mRNA. Cell proliferation analysis showed that overexpression of circENTPD7 promoted the proliferation of NSCLC cells and reduced the inhibitory effects of overexpression of PTEN on cell proliferation. 35993557 circSCN8A CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Regulation(miR-1290/ACSL4 axis) IHC//Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In this study, we found that circSCN8A expression was down-regulated in NSCLC tissues and cells. Low circSCN8A expression was positively associated with aggressive clinicopathological characteristics and poor prognosis in NSCLC patients. CircSCN8A suppressed cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro and blocked tumor growth in vivo. Moreover, circSCN8A promoted cell ferroptosis in NSCLC. Mechanistically, circSCN8A acted as a competing endogenous RNA (ceRNA) by sponging miR-1290 to enhance the expression of long-chain acyl-CoA synthetase-4 (ACSL4). Furthermore, the knockdown of ACSL4 or overexpression of miR-1290 reversed the effect of circSCN8A on facilitating ferroptosis and inhibiting cell proliferation and metastasis. In summary, circSCN8A represses cell proliferation and metastasis in NSCLC by regulating the miR-1290/ACSL4 axis to induce ferroptosis. Thus, circSCN8A may represent a promising therapeutic target against NSCLC. Low circSCN8A expression was positively associated with aggressive clinicopathological characteristics and poor prognosis in NSCLC patients. Yes CircSCN8A suppressed cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro and blocked tumor growth in vivo. Moreover, circSCN8A promoted cell ferroptosis in NSCLC. Mechanistically, circSCN8A acted as a competing endogenous RNA (ceRNA) by sponging miR-1290 to enhance the expression of long-chain acyl-CoA synthetase-4 (ACSL4). Furthermore, the knockdown of ACSL4 or overexpression of miR-1290 reversed the effect of circSCN8A on facilitating ferroptosis and inhibiting cell proliferation and metastasis. 36482742 hsa_circ_100876 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Expression[highly expressed] qRT-PCR CircRNA_100876 expression was upregulated (P<0.05) and was negatively correlated with survival outcome (P<0.05) in ESCC. CircRNA_100876 expression was upregulated (P<0.05) and was negatively correlated with survival outcome (P<0.05) in ESCC. Yes Inhibition of proliferation, migration, invasion, and epithelial-mesenchymal transition progression was confirmed after circRNA_100876 depletion. 30425526 hsa_circ_0006948 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Regulation[miR-490-3p/HMGA2 axis] qRT-PCR We first screened circRNA expression profiles using a circRNA microarray, and found that the expression of a novel circRNA, hsa_circ_0006948, is increased in 153 ESCC tissues and cell lines compared with noncancerous tissues and cell lines. Furthermore, we analyzed the relationship between hsa_circ_0006948 and miR-490-3p through bioinformatics, luciferase reporter assays, RNA immunoprecipitation and qRT-PCR. We found that hsa_circ_0006948 could bind directly to miR-490-3p which targets the 3'UTR of the oncogene HMGA2 to induce EMT. In conclusion, hsa_circ_0006948 was overexpressed in ESCC tissues and promoted cancer progression, and it could induce EMT by enhancing HMGA2 by sponging miR-490-3p, suggesting that hsa_circ_0006948 could be a biomarker for ESCC. Additionally, high hsa_circ_0006948 levels were positively associated with lymphatic metastasis and poor prognosis. Yes Functionally, the assays indicated that cell proliferation, migration and invasion were promoted by hsa_circ_0006948 both in vitro and in vivo. 31881015 hsa_circ_0006168 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction[sponges miR-100 and regulates mTOR] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray//Transwell Assay .Our results suggested that, hsa_circ_0006168 was remarkably increased not only in ESCC tissues but also in cell lines compared with those in normal cases. Mechanically, it was discovered in this study that hsa_circ_0006168 might regulate the expression of Mammalian Target of Rapamycin (mTOR) by sponging microRNA-100 (miR-100). Taken together, hsa_circ_0006168 can promote ESCC proliferation, migration and invasion through the competing endogenous RNA (ceRNA) mechanism, which has been first confirmed in our results. In ESCC, hsa_circ_0006168 can serve as a potential diagnostic biomarker and therapeutic target. Besides, high hsa_circ_0006168 expression was positively connected with lymph node metastasis and TNM stage of ESCC patients. Yes In vitro, the proliferation, invasion and migration capacities of ESCC cells were suppressed through down-regulating hsa_circ_0006168 expression. 31229921 hsa_circ_0000654 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues,cell lines Interaction[miR-149-5p/IL-6/STAT3 pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//BrdU//Transwell Assay Circ_0000654 was significantly upregulated in ESCC tissues and cell lines, and its high expression was remarkably associated with an increased T stage and local lymph node metastasis in ESCC patients.Circ_0000654 was identified as a sponge of miR-149-5p and facilitated ESCC progression by indirectly activating the IL-6/STAT3 signaling pathway. Additionally, knocking down circ_0000654 strikingly repressed ESCC growth and metastasis in vivo. In summary, circ_0000654 functions as an oncogenic circRNA in ESCC and accelerates ESCC progression via adsorbing miR-149-5p and activating the IL-6/STAT3 signaling pathway. Yes Circ_0000654 overexpression and knockdown experiments revealed that circ_0000654 regulated ESCC cell proliferation, migration, invasion, and apoptosis in vitro. 31778020 circSMAD7 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma blood,ESCC tissues Expression[lower expressed] qRT-PCR The expression of circ-SMAD7 was validated to be significantly down-regulated in ESCC plasmas in comparison with normal controls, showing a high negative correlation with TNM stage (P = 0.000) and lymphatic metastasis (P = 0.000). Moreover, circ-SMAD7 was significantly down-regulated in ESCC tissues compared to adjacent normal tissues. The expression of circ-SMAD7 was validated to be significantly down-regulated in ESCC plasmas in comparison with normal controls, showing a high negative correlation with TNM stage (P = 0.000) and lymphatic metastasis (P = 0.000). Yes Furthermore, Loss-of-function and gain-of-function experiments revealed that the expression level of circ-SMAD7 affected the proliferation and migration of ESCC cell lines. 30611100 hsa_circ_0000337 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction[bind to miR-670-5p ] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay hsa_circ_0000337 was significantly upregulated in ESCC tissues compared to adjacent normal-appearing tissues (P<0.0001). Bioinformatics predicted and luciferase reporter assay verified that hsa_circ_0000337 could bind to miR-670-5p, a ncRNA involved in carcinogenesis. Yes Knockdown of hsa_circ_0000337 significantly inhibited cell proliferation, migration, and invasion in TE-1 and KYSE-150 cell lines. 30881124 circTTC17 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cells, plasma, and tissues Expression[highly expressed] CCK8//qRT-PCR//Wound Healing Assay The expression level of circ-TTC17 was found to be significantly higher in ESCC cells, plasma, and tissues compared with normal cases. Yes In vitro experiments indicated that circ-TTC17 promoted proliferation and migration of ESCC cells. 30519852 circZDHHC5 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues,blood regulation[miR-217/ZEB1 Axis] qRT-PCR//Luciferase Report Assay//FISH circ-ZDHHC5, rather than linear ZDHHC5 mRNA, rose in the tissues of patients with ESCC, plasma, and ESCC cell lines in comparison with normal controls. It provides a novel perceptivity for the treatment of ESCC suggesting that circ-ZDHHC5 could impact on ESCC progression by sponging miR-217 with ZEB1. Yes Knockdown of circ-ZDHHC5 inhibited tumorigenesis in ESCC cells, and the co-transfection of si-circ-ZDHHC5 and miR-217 mimics further enhanced the above effect. 33392180 hsa_circ_0120816 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues regulation[inhibiting miR-1305 and releasing TXNRD1] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay Experimental investigations revealed that circ0120816 was the highest upregulated circRNA in ESCC tissues and that this non-coding RNA acted as a miR-1305 sponge in enhancing cell viability, cell proliferation, and cell adhesion as well as repressing cell apoptosis in ESCC cell lines.This research confirmed that circ0120816 played an active role in promoting ESCC development by targeting miR-1305 and upregulating oncogene TXNRD1. Yes Furthermore, silencing circ0120816 was found to repress ESCC tumor growth and metastasis in vivo. 33292234 hsa_circ_6448-14 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines interaction[miR-455-3p] qRT-PCR//RNA Pull-Down hsa_circRNA6448-14 was significantly upregulated in ESCC tissues and cell lines. hsa_circRNA6448-14 functioned as a miRNA sponge to competitively bind miR-455-3p, and hsa_circRNA6448-14 expression negatively correlated with that of miR-455-3p. hsa_circRNA6448-14 upregulation was correlated with poor differentiation, advanced pTNM stage, poor disease-free survival (DFS), and poor overall survival (OS). Yes Elevated hsa_circRNA6448-14 promoted cell proliferation, migration, invasion, and inhibited apoptosis in vitro. 32805720 circLPAR3 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells interaction[sponging miR-375/miR-433 ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay CircLPAR3 was upregulated in ESCC tissues and cells, and its high expression was related to the poor prognosis of ESCC patients.CircLPAR3 might play an oncogenic role in ESCC through sponging miR-375/miR-433 to promote HMGB1 expression, which might provide a theoretical basis for circLPAR3 to become a biomarker for ESCC therapy. CircLPAR3 was upregulated in ESCC tissues and cells, and its high expression was related to the poor prognosis of ESCC patients. Yes CircLPAR3 was a stable cyclic transcript, mainly located in the cytoplasm, and its knockdown hindered the proliferation, migration and invasion of ESCC cells and inhibited ESCC tumor growth in vivo. 32801782 circNTRK2 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells regulation[NRIP1 ,miR-140-3p] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining CircNTRK2 was highly expressed in ESCC tissues and cells. CircNTRK2 promoted ESCC progression by regulating miR-140-3p/NRIP1 pathway. High expression of circNTRK2 was correlated with advanced TNM stage, lymph node metastasis and short survival. Yes Knockdown of circNTRK2 inhibited ESCC cell proliferation, invasion and epithelial-mesenchymal transition (EMT), and accelerated apoptosis in vitro. 32653032 hsa_circ_0006220 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells and tissues Interaction(miR-203-3p/RGS17 ) EdU Staining//CCK8//qRT-PCR//Bioinformatics Analysis//Transwell Assay The expression of circ_0006220 was elevated in NSCLC cells and tissues, and high circ_0006220 expression was significantly associated with unfavorable clinicopathological indicators. Furthermore, miR-203-3p was identified as a downstream target of circ_0006220, and circ_0006220 could sponge miR-203-3p; RGS17 was identified as a downstream target of miR-203-3p and was positively modulated by circ_0006220. The expression of circ_0006220 was elevated in NSCLC cells and tissues, and high circ_0006220 expression was significantly associated with unfavorable clinicopathological indicators. Yes In addition, it was revealed that circ_0006220 overexpression facilitated NSCLC cell growth, migration, and invasion, whereas knocking down circ_0006220 had contrary effects. 35041543 hsa_circ_0074027 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-335-5p/CUL4B ) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay High expression of circ_0074027 was found in NSCLC tissues and cells.Circ_0074027 acted as a sponge of miR-335-5p. The effect of circ_0074027 knockdown on NSCLC progression was weakened by miR-335-5p inhibition. Moreover, CUL4B was a target gene of miR-335-5p. CUL4B overexpression reversed the inhibitory effects on cell viability, cell cycle process, and colony formation and the promotional effect on cell apoptosis caused by miR-335-5p in NSCLC. Yes Circ_0074027 knockdown suppressed cell viability, cell cycle process, and colony formation and promoted apoptosis in NSCLC cells in vitro and inhibited tumor growth in vivo. 32580576 hsa_circ_0008797 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-301a-3p/SOCS2) RNA Pull-Down//ISH//Tunel//CCK8//RIP//Luciferase Report Assay//Transwell Assay circ_0008797 was low expressed in NSCLC tissues and cell lines, associating with poor outcome (p <.05). circ_0008797 attenuated malignant phenotype of NSCLC cells by sponging miR-301a-3p. circ_0008797 facilitated SOCS2 expression by sponging miR-301a-3p. SOCS2 knockdown partially reversed the inhibitory effect of miR-301a-3p inhibition on NSCLC cells malignant phenotype (p <.05). circ_0008797 attenuated NSCLC prolifearion and metastasis in vivo (p <.05). Yes circ_0008797 inhibited proliferation, migration, invasion, and glycolysis, but enhanced apoptosis of NSCLC cells (p <.05). 35305058 hsa_circ_0000520 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-1258/AKT3 Axis) CCK8//qRT-PCR//Western Blot circ_0000520 was upregulated in NSCLC. miR-1258 was identified as the downstream target of circ_0000520. miR-1258 overexpression weakened the effect of circ_0000520 overexpression on NSCLC cells. miR-1258 targeted and inhibited AKT3. circ_0000520 positively regulated the AKT3 expression in NSCLC cells by sponging miR-1258. Highly expressed circ_0000520 is linked to the NSCLC patient's advanced TNM stage and lymph node metastasis. Yes circ_0000520 overexpression facilitated NSCLC cell growth, migration, and invasion. 36593867 hsa_circ_0001666 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-1184/miR-548I/AGO1 axis) Wound Healing Assay//Migration Assay//RIP//FISH//Luciferase Report Assay//Invasion Assay Herein, we discovered that a circRNA, hsa_circ_0001666 (circ0001666), was highly expressed in NSCLC tissues and cell lines, and it was positively correlated with NSCLC tumor pathological grade and lymph node metastasis. Mechanistically, circ0001666 could act as a sponge to miR-1184/miR-548I and upregulate the expression of AGO1, thereby promoting the activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway in NSCLC cells. Herein, we discovered that a circRNA, hsa_circ_0001666 (circ0001666), was highly expressed in NSCLC tissues and cell lines, and it was positively correlated with NSCLC tumor pathological grade and lymph node metastasis. Moreover, Kaplan-Meier survival analysis implied that NSCLC patients with high circ0001666 expression were negatively correlated with favorable survival. Yes Functionally, circ0001666 could promote migration and invasion of NSCLC cells in vitro and in vivo. 35284630 circSHKBP1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction( miR-1294/PKM2 axis) RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//ELISA//Colony Formation Assay circSHKBP1 was found to be upregulated in NSCLC tissues and cell lines and was enriched in exosomes derived from NSCLC cells. miRNA-1294 was identified as a target for circSHKBP1, and circSHKBP1 upregulated PKM2 expression by sponging miR-1294. Exosomal circSHKBP1 regulated glycolysis through PKM2 in a HIF-1α-dependent manner in NSCLC cells and promoted M2 polarization and macrophage recruitment. Moreover, exosomal circSHKBP1 promoted NSCLC cell growth, metastasis, and M2 infiltration in vivo. Thus, exosomal circSHKBP1 participated in the progression of NSCLC via the miR-1294/PKM2 axis. circSHKBP1 may be potential biomarker for the diagnosis and treatment of NSCLC. Yes Exosomal circSHKBP1 enhanced the proliferation, migration, invasion, and stemness of NSCLC cells. 35229026 circLIFR CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-429/CELF2/PTEN/AKT-signaling pathways ) CCK8//qRT-PCR//Colony Formation Assay//EdU Staining CircLIFR, circular, and stable transcript in NSCLC cells, was decreased more than 2 folds in NSCLC tissues and cells than controls (P < 0.0001). Importantly, overexpression of circLIFR impeded cell proliferation, migration, invasion, and inactivated protein kinase B (AKT)/phosphatase and tensin homolog (PTEN)-signaling pathways while enhanced apoptosis and cell-cycle arrest in NSCLC cells, which was overturned by upregulation of miR-429 or silencing of CELF2. Furthermore, the upregulation of circLIFR inhibited NSCLC tumor growth in vivo. Yes Importantly, overexpression of circLIFR impeded cell proliferation, migration, invasion, and inactivated protein kinase B (AKT)/phosphatase and tensin homolog (PTEN)-signaling pathways while enhanced apoptosis and cell-cycle arrest in NSCLC cells, which was overturned by upregulation of miR-429 or silencing of CELF2. Furthermore, the upregulation of circLIFR inhibited NSCLC tumor growth in vivo. 36104590 circPITX1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-30e-5p/ITGA6 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay circ-PITX1 was substantially up-regulated in NSCLC tissues and cells, and circ-PITX1 up-regulation was correlated with NSCLC patients' poor survival. Mechanistically, circ-PITX1 acted as a sponge of miR-30e-5p, which targeted the 3'untranslated region (UTR) of ITGA6. Knockdown of circ-PITX1 or overexpressing miR-30e-5p reduced ITGA6/PI3K/AKT axis. circ-PITX1 was substantially up-regulated in NSCLC tissues and cells, and circ-PITX1 up-regulation was correlated with NSCLC patients' poor survival. Yes Functionally, circ-PITX1 overexpression or miR-30e-5p inhibition markedly facilitated proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), reduced apoptosis, and enhanced ITGA6/PI3K/AKT expression in NSCLC cells, whereas circ-PITX1 knockdown or miR-30e-5p up-regulation resulted in the opposite results. 35007184 hsa_circ_0025039 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-636/CORO1C axis) CCK8//qRT-PCR//Western Blot The expression of circ_0025039 and CORO1C was significantly increased, while miR-636 was decreased in NSCLC tissues and cells compared with controls. The neoplasm formation was repressed after circ_0025039 silencing. Additionally, circ_0025039 acted as a sponge for miR-636, which was found to target CORO1C. Importantly, the contribution of circ_0025039 to NSCLC progression was mediated by miR-636/CORO1C axis. Yes Circ_0025039 depletion repressed NSCLC cell proliferation, migration, invasion, tube-forming capacity, and sphere formation ability, but induced cell apoptosis. 35034254 hsa_circ_0007385 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-337-3p/LMO3 ) CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining Circ_0007385 expression was notably enhanced in NSCLC tissues and cell lines. Circ_0007385 acted as a sponge for microRNA-337-3p (miR-337-3p), and circ_0007385 overexpression-mediated effects were largely overturned by the overexpression of miR-337-3p in NSCLC cells. MiR-337-3p interacted with the 3' untranslated region (3'UTR) of LIM-only protein 3 (LMO3). Circ_0007385 up-regulated LMO3 level by absorbing miR-337-3p in NSCLC cells. LMO3 overexpression largely reversed miR-337-3p overexpression-induced influences in NSCLC cells. Yes Circ_0007385 facilitated the proliferation but suppressed the apoptosis of NSCLC cells. Circ_0007385 knockdown significantly restrained the growth of xenograft tumors in vivo. 36426731 hsa_circ_0006677 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC samples and cells Interaction(miR-1245a/SATB2 ) qRT-PCR//Western Blot We observed the downregulation of circ_0006677 in NSCLC samples and cells. Molecular mechanism experiments exhibited that circ_0006677 functioned as a miR-1245a sponge and mediated SATB2 expression through adsorbing miR-1245a. Either miR-1245a overexpression or SATB2 knockdown weakened circ_0006677 overexpression-mediated repression on proliferation, invasion, migration, and stemness. Yes Functionally, circ_0006677 overexpression decreased xenograft tumor growth and restrained NSCLC cell proliferation, invasion, migration, stemness, and induced NSCLC cell apoptosis in vitro. 35081869 hsa_circ_0007385 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells and tissues Interaction(miR-493-3p/RAB22A axis) CCK8//qRT-PCR//Western Blot Expression of circ_0007385 and RAB22A increased, whereas miR-493-3p level was decreased in NSCLC tissues in contrast to that in normal tissues. Mechanically, circ_0007385 acted as a miR-493-3p sponge to modulate RAB22A expression. Moreover, circ_0007385 could regulate the development of NSCLC by sponging miR-493-3p to regulate the expression of RAB22A. Yes For functional analysis, circ_0007385 deficiency inhibited cell proliferation and stemness, whereas it promoted cell apoptosis in NSCLC cells. In addition, circ_0007385 silence also attenuated tumor growth in vivo. 34989145 hsa_circ_0006427 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-346/VGLL4 Pathway) qRT-PCR Circ_0006427 expression was down-regulated in NSCLC tissues and cells, and circ_0006427 suppressed multiplication, migration, invasion and EMT of NSCLC cells. miR-346 expression was upregulated in NSCLC tissues and cells, and miR-346 worked as a target of circ_0006427. VGLL4 was down-regulated in NSCLC tissues and cells, and knockdown of VGLL4 accelerated multiplication, migration, invasion and EMT of NSCLC cells. Circ_0006427 enhanced VGLL4 expression by competitively binding with miR-346. Yes Circ_0006427 expression was down-regulated in NSCLC tissues and cells, and circ_0006427 suppressed multiplication, migration, invasion and EMT of NSCLC cells. 35717572 hsa_circ_0002476 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-1182/TFAM axis) CCK8//qRT-PCR//Western Blot Circ_0002476 was overexpressed in NSCLC tissues and cells.Circ_0002476 could sponge miR-1182, and miR-1182 inhibitor reversed the influence induced by circ_0002476 knockdown. Moreover, TFAM was targeted by miR-1182, and miR-1182 hindered NSCLC cell progression by regulating TFAM. Additionally, circ_0002476 silencing could reduce NSCLC tumor growth by miR-1182/TFAM. Yes Circ_0002476 knockdown suppressed NSCLC cell proliferation and invasion, while promoted apoptosis and mtDNA damage. 36056804 circCAMSAP1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC lung tissues and cell lines Interaction( circCAMSAP1/miR-1182/BIRC5 axis) qRT-PCR//Western Blot Overexpression of circCAMSAP1 has been demonstrated in NSCLC lung tissues and cell lines.Furthermore, a luciferase assay revealed that circCAMSAP1 could regulate baculoviral inhibitor of apoptosis protein (IAP) repeat containing 5 (BIRC5, also known as survivin) expression by directly binding to miR-1182. However, BIRC5 without 3' untranslated regions (3'UTR) could reverse the influence of downregulated circCAMSAP1 on proliferation and apoptosis in NSCLC. Together, our findings reveal a novel mechanism by which the circCAMSAP1/miR-1182/BIRC5 axis promotes NSCLC progression. Yes We also found that downregulated circCAMSAP1 repressed cell proliferation and increased apoptosis of NSCLC cells in vitro and suppressed xenograft tumor growth in vivo. 35132928 circPLK1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patients and cells Interaction(miR-1294/HMGA1 axis) qRT-PCR//Western Blot The Kaplan-Meier survival analysis revealed that a high expression level of circPLK1 was associated with a poorer prognosis in NSCLC patients. Molecular analyses demonstrated that circPLK1 directly targets miR-1294 and negatively regulates its activity. And circPLK1 overexpression facilitates the progression of NSCLC by negatively regulating miR-1294 level and maintaining a high-level expression of HMGA1 (High Mobility Group Protein A1). Our study suggests that circPLK1 upregulation plays an important role in NSCLC progression by targeting miR-1294/HMGA1 axis. The Kaplan-Meier survival analysis revealed that a high expression level of circPLK1 was associated with a poorer prognosis in NSCLC patients. Yes Exosomes extracted from NSCLC serum could promote the replication, migration, and invasion of NSCLC cells and suppress apoptotic cell death. The overexpression of circPLK1 also promotes the malignant phenotype of NSCLC cells. 35114891 hsa_circ_0006423 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue and cell line Interaction(miR-492) CCK8//qRT-PCR We found has_circ_0006423 is lower expressed in NSCLC and miR-492 is opposite, has_circ_0006423 and miR-492 has diagnostic value in NSCLC.cThis effect may be due to the combination of has_circ_0006423 and miR-492 affecting the progression of NSCLC. Yes In A549 and NCI-H1299 cells, hsa_circ_0006423 inhibited the proliferation, migration, and invasion of NSCLC cells by sponging miR-492 and accelerating NSCLC cell apoptosis. 35962012 hsa_circ_0016760 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-876-3p/NOVA2 Axis) CCK8//qRT-PCR Circ_0016760 and NOVA2 were upregulated, while miR-876-3p expression was decreased in NSCLC tissues and cells.Circ_0016760 acted as a sponge of miR-876-3p, and miR-876-3p could target NOVA2. Circ_0016760 might play vital roles in NSCLC by regulating miR-876-3p/NOVA2 axis. Circ_0016760 could promote the malignant development of NSCLC through miR-876-3p/NOVA2 axis, at least in part. Yes Circ_0016760 depletion suppressed NSCLC cell proliferation and metastasis in vitro, as well as hampered tumor growth in vivo. 35239092 circRAD23B CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-142-3p/MAP4K3 axis) CCK8//qRT-PCR//Western Blot Circ-RAD23B was shown to be upregulated in NSCLC tissues and cells. Knockdown of circ-RAD23B inhibited proliferation, migration, invasion, angiogenesis and promoted cell cycle arrest and apoptosis in NSCLC cells, and circ-RAD23B knockdown also impeded tumor growth in vivo. Yes Knockdown of circ-RAD23B inhibited proliferation, migration, invasion, angiogenesis and promoted cell cycle arrest and apoptosis in NSCLC cells, and circ-RAD23B knockdown also impeded tumor growth in vivo. 35106926 hsa_circ_0017639 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation(PI3K/AKT signaling pathway) CCK8//qRT-PCR//Western Blot Circ_0017639 expression was remarkably high in the NSCLC tissues and cell lines. We further showed that circ_0017639 knockdown suppressed the cellular development via PI3K/AKT cascade inactivation. Yes The transfection experiments showed that circ_0017639 overexpression was able to promote proliferative, migratory, and invasive properties of NSCLC cells, while sh-circ_0017639 showed opposing effects. 35000535 hsa_circ_0007385 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-1253/FAM83A axis) CCK8//qRT-PCR//Western Blot Circ_0007385 was upregulated in NSCLC tissues and cells. In addition, miR-1253 was a direct target of circ_0007385, and miR-1253 reversed the inhibitory effects of circ_0007385 on cell proliferation and stemness in NSCLC cells. Moreover, FAM83A was a direct target of miR-1253, and miR-1253 suppressed NSCLC cell proliferation and stemness by targeting FAM83A. Exosomal circ_0007385 promoted NSCLC cell proliferation and stemness by regulating miR-1253/FAM83A axis. Yes Knockdown of circ_0007385 inhibited NSCLC cell proliferation and stemness, while exosomal circ_0007385 facilitated NSCLC cell proliferation and stemness. Furthermore, circ_0007385 knockdown inhibited tumor growth in vivo. 34620741 circSFMBT2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-7-5p/ADAM10 axis) CCK8//Flow Cytometry//EdU Staining//Transwell Assay The expression levels of circ-SFMBT2 and ADAM10 were increased in NSCLC tissues and cell lines, while decreased the expression of miR-7-5p. circ-SFMBT2 was negatively correlated with miR-7-5p, while miR-7-5p was negatively correlated with ADAM10.circ-SFMBT2 could target miR-7-5p, and ADAM10 was the target gene of miR-7-5p. The combined effect of silencing circ-SFMBT2 and inhibition of miR-7-5p, as well as miR-7-5p overexpression and ADAM10 overexpression could promote cell proliferation, clone formation and invasion, and also suppress cell apoptosis. Yes Silencing the overexpression of circ-SFMBT2 and miR-7-5p could inhibit cell proliferation, clone formation and invasion, and also promote apoptosis. Silencing circ-SFMBT2 could inhibit the growth of transplanted tumors. 35076912 circTP53 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues,cell lines regulation[miR-876-3p/CDKL3 axis] Western Blot//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay In our study, we found circTP53 was significantly up-regulated in colorectal cancer tissues from patients and in colorectal cell lines. In conclusion, circTP53 was highly expressed in colorectal cancer tissues, and promoted colorectal cancer progression via modulating miR-876-3p/CDKL3 axis. Yes At last, we suggested that circTP53 knockdown could inhibit colorectal cancer progression in vivo. 33232736 circTBL1XR1 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues regulation[CircTBL1XR1/miR-424 axis ] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay circTBL1XR1 was highly expressed in colon cancer patients.circTBL1XR1 was highly expressed in colon cancer, and miR-424 was poorly expressed in colon cancer cells. circTBL1XR1 regulates the expression of Smad7 through miR-424, thereby affecting the malignant progression of colorectal cancer. Yes In vivo and in vitro experimental results showed that overexpression of circTBL1XR1 enhanced the proliferation, migration, and invasion of colon cancer cells. After lowering circTBL1XR1, the ability of migration and invasion of colon cancer cells was significantly reduced. 33209488 circFOXO3 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Interaction(miR-545-3p/miR-506-3p/HMGB3 ) qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis//Western Blot Here, we show thatcircFOXO3 in NSCLC promotes the proliferation, migration and invasion of NSCLC cells, thereby promoting tumor growth. We further find that circFOXO3 sponges miR-545-3p/miR-506-3p that bind to 3'-UTR of HMGB3 mRNA, which constitutes the major network fulfilling the circFOXO3's promoting effect. Yes Here, we show thatcircFOXO3 in NSCLC promotes the proliferation, migration and invasion of NSCLC cells, thereby promoting tumor growth. 35038619 hsa_circ_0006508 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer samples and cells Interaction( miR-1272) qRT-PCR//Western Blot//ChIP Upregulated circ_0006508 and downregulated miR-1272 were observed in colorectal cancer samples, which was associated with the TNM stage and overall survival. Functional assays demonstrated that the hypoxia-induced upregulated circ_0006508 and downregulated miR-1272 promoted the viability and Warburg effect of colorectal cancer in vitro. Mechanistically, HIF-1α-induced circ_0006508 could directly sponge miR-1272, which played a suppressive role in glycolysis. Upregulated circ_0006508 and downregulated miR-1272 were observed in colorectal cancer samples, which was associated with the TNM stage and overall survival. Yes Functional assays demonstrated that the hypoxia-induced upregulated circ_0006508 and downregulated miR-1272 promoted the viability and Warburg effect of colorectal cancer in vitro. 36397308 circMERTK CircRNA Homo sapiens Colorectal Neoplasms TAMs Interaction( circMERTK/miR-125a-3p/IL-10 axis) qRT-PCR//Western Blot Of note, the expression of circMERTK was remarkably overexpressed in TAMs. The ISH assay displayed that the expressions of circMERTK were mainly overlapped with macrophages marker CD68, and the abundance of circMERTK in CRC tissues was much higher than that in matched normal tissues. Mechanically, TAM-like cell could exert immunosuppressive activity via circMERTK/miR-125a-3p/IL-10 axis. Yes Functionally, circMERTK knockdown resulted in attenuated CD8+ T cell apoptosis in the co-culture assay, indicating that circMERTK could have an impact on the immunosuppressive activity of TAM-like cell. 36163585 circPLXNB1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-4701-5p) qRT-PCR//MTT//Western Blot//Transwell Assay The results showed that gene expression of circ_PLXNB1 in CRC tissues was significantly downregulated. Mechanistically, circ_PLXNB1 exerted its functional effects by binding with miR-4701-5p. Moreover, TUSC1 siRNA partially abolished the suppressive effect of the miR-4701-5p inhibitor or circ_PLXNB1 on CRC cell malignant behaviors. Yes Overexpression of circ_PLXNB1 inhibited the malignant behaviors of CRC cells, as manifested by the decrease in cell proliferation, cell invasion, migration, and EMT. 35434854 hsa_circ_0011385 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues or cells Interaction( miR-330-3p/MYO6 axis) In Vivo Experiment//qRT-PCR//Luciferase Report Assay//Western Blot Circ_0011385 and MYO6 expression were dramatically upregulated, while miR-330-3p expression was downregulated in CRC tissues or cells compared with control groups.Circ_0011385 was associated with miR-330-3p, and miR-330-3p targeted MYO6. Circ_0011385 knockdown inactivated MEK1/2/ERK1/2 signaling pathway by miR-330-3p/MYO6 axis. Circ_0011385 expression was associated with tumor size, tumor-node-metastasis stage (TNM) stage and lymph node metastasis of CRC patients. Yes Circ_0011385 silencing or MYO6 absence repressed cell proliferation, migration and invasion, whereas induced cell apoptosis in CRC. Additionally, miR-330-3p inhibitor or MYO6 overexpression attenuated the repressive impacts of circ_0011385 silencing on CRC process. 35091088 circRHOBTB3 CircRNA Homo sapiens Colorectal Neoplasms tissue samples Expression(highly expressed) IF circRHOBTB3 levels were increased in the sera but was downregulated in tissue samples in CRC, and the downregulation was associated with poor prognosis. circRHOBTB3 levels were increased in the sera but was downregulated in tissue samples in CRC, and the downregulation was associated with poor prognosis. Yes Furthermore, circRHOBTB3 acts a tumor-suppressive circRNA by repressing metabolic pathways, intracellular ROS production in CRC. 35148775 circATAD1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-618 ) CCK8//qRT-PCR//Colony Formation Assay Circ-ATAD1 was upregulated in CRC and predicted poor survival. In addition, circ-ATAD1 was inversely correlated with mature miR-618 but not premature miR-618. In CRC cells, circ-ATAD1 overexpression decreased the level of mature miR-618 but not premature miR-618. A direct interaction between circ-ATAD1 and miR-618 was observed. Moreover, circ-ATAD1 overexpression reduced the inhibitory effects of miR-618 overexpression on cell proliferation. Circ-ATAD1 was upregulated in CRC and predicted poor survival. Yes A direct interaction between circ-ATAD1 and miR-618 was observed. Moreover, circ-ATAD1 overexpression reduced the inhibitory effects of miR-618 overexpression on cell proliferation. 35505304 hsa_circ_0006174 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR‑1205/CCBE1/Wnt pathway) Western Blot//Tunel//CCK8//qRT-PCR//Luciferase Report Assay Circ_0006174 showed a notable upregulation in CRC tissues and cell lines and its overexpression was linked to larger tumor diameter and advanced T stage of CRC patients. Mechanistically, circ_0006174 could decoy miR‑1205 to up‑modulate CCBE1 expression and Wnt pathway‑related proteins (c‑Myc and cyclin D1). Circ_0006174 is an oncogenic circRNA, which participates in the promotion of CRC progression by regulating the miR‑1205/CCBE1/Wnt pathway. Circ_0006174 showed a notable upregulation in CRC tissues and cell lines and its overexpression was linked to larger tumor diameter and advanced T stage of CRC patients. Yes Circ_0006174 knockdown significantly suppressed cell growth and metastatic potential and promoted cell apoptosis in vitro. Circ_0006174 knockdown accelerated the lung metastasis in vivo. 35674190 circCDC6 CircRNA Homo sapiens Colorectal Neoplasms CRC tumor samples and cells Interaction(miR-3187-3p/PRKAA2) IHC//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay CircCDC6 showed poor expression in CRC tumor samples and cells. MiR-3187-3p was targeted by circCDC6, and miR-3187-3p depletion also repressed CRC cell growth and glycolysis. PRKAA2 was a downstream target of circCDC6/miR-3187-3p pathway, and circCDC6 upregulated PRKAA2 expression via targeting miR-3187-3p. PRKAA2 knockdown rescued the functional effects of circCDC6 ectopic expression. Yes CircCDC6 ectopic expression repressed CRC cell proliferation, survival and glycolysis energy metabolism. CircCDC6 overexpression in vivo impeded tumor development in animal models. 35438362 circTDRD3 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(HIF1α/PTBP1/circTDRD3/miR-1231/HIF1α axis) ISH//qRT-PCR//RNA Pull-Down The expression of circTDRD3 was highly expressed in CRC tissues and positively correlated with overall survival, tumor size, lymph node invasion and clinical stage. Mechanistically, circTDRD3 promoted HIF1α expression by sponging miR-1231, which facilitated CRC progression. Meanwhile, HIF1α directly combined with TDRD3 promoter to increase the expression of TDRD3 pre-mRNA. Then HIF1a-induced PTBP1 accelerated the formation of circTDRD3. The expression of circTDRD3 was highly expressed in CRC tissues and positively correlated with overall survival, tumor size, lymph node invasion and clinical stage. Yes CircTDRD3 facilitated CRC cell proliferation, migration and metastasis in vitro and in vivo. 36418471 circCAPRIN1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissue specimens Interaction(STAT2 ) ChIP//Western Blot//ISH//qRT-PCR//FISH//IHC//IF Among circRNAs, circCAPRIN1 was most significantly upregulated in CRC tissue specimens. circCAPRIN1 expression was positively correlated with the clinical stage and unfavorable prognosis of CRC patients.Further mechanistic assays demonstrated that circCAPRIN1 directly bound signal transducer and activator of transcription 2 (STAT2) to activate ACC1 transcription, thus regulating lipid metabolism and facilitating CRC tumorigenesis. Among circRNAs, circCAPRIN1 was most significantly upregulated in CRC tissue specimens. circCAPRIN1 expression was positively correlated with the clinical stage and unfavorable prognosis of CRC patients. Yes Downregulation of circCAPRIN1 suppressed proliferation, migration, and epithelial-mesenchymal transition of CRC cells, while circCAPRIN1 overexpression had opposite effects.RNA sequencing and gene ontology analysis indicated that circCAPRIN1 upregulated the expressions of genes involved in CRC lipid metabolism. Moreover, circCAPRIN1 promoted lipid synthesis by enhancing Acetyl-CoA carboxylase 1 (ACC1) expression. 36328987 circKIAA1199 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-34c-5p/MSI1 ) Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of circ_KIAA1199 was elevated in CRC. MiR-34c-5p was a target of circ_KIAA1199. The effects of circ_KIAA1199 downregulation were reversed by miR-34c-5p deficiency. In addition, MSI1 was a target of circ_KIAA1199, and the inhibitory effects of miR-34c-5p restoration on CRC cell proliferation, survival, migration and invasion were reversed by MSI1 overexpression. Circ_KIAA1199 positively regulated MSI1 expression by targeting miR-34c-5p. Yes Circ_KIAA1199 downregulation suppressed CRC cell proliferation, survival, migration and invasion. 34387591 hsa_circ_0000395 CircRNA Homo sapiens Colorectal Neoplasms CRC samples and cell lines Interaction(miR-432-5p/MYH9) Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay Circ_0000395 was strongly expressed in CRC samples and cell lines. Mechanistically, circ_0000395 sequestered miR-432-5p to regulate MYH9 expression. Furthermore, miR-432-5p knockdown reversed circ_0000395 silencing-mediated effects on CRC cell malignant phenotypes. MYH9 overexpression counteracted the inhibiting effects of miR-432-5p upregulation on CRC cell malignant phenotypes. Additionally, CRC cells derived from exosomal circ_0000395 promoted cancer cell malignant phenotypes. Yes Also, circ_0000395 repressed CRC growth in mouse models in vivo and induced CRC cell apoptosis, restrained CRC cell proliferation, migration, invasion, and EMT in vitro. 35759156 circALG1 CircRNA Homo sapiens Colorectal Neoplasms peripheral blood and tumour tissues of patients Interaction(miR-342-5p/PGF ) qRT-PCR//FISH//RIP//Transwell Assay CircALG1 was highly expressed in both the peripheral blood and tumour tissues of patients with CRC and was closely associated with CRC metastasis. Further mechanistic studies showed that circALG1 upregulated the expression of placental growth factor (PGF) by binding to miR-342-5p and that m6A modification enhanced the binding of circALG1 to miR-342-5p and promoted its ceRNA function. Yes CircALG1 overexpression promoted the migration and invasion of CRC cells, and circALG1 silencing and reduction of the circALG1 m6A modification level inhibited CRC cell migration and invasion. In vivo experiments further confirmed the prometastatic role of circALG1 in CRC. 35305647 circIFT80 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and tumor cells Interaction(miR-142, miR-568, and miR-634/ Wnt/β-catenin pathway) qRT-PCR//Wound Healing Assay//Luciferase Report Assay In this present study, we found that circIFT80 was abnormally overexpression in colorectal cancer tissues and tumor cells. In conclusion, our work reveals the impacts of circIFT80 as ceRNA in the progression of CRC, by which sponging miR-142, miR-568, and miR-634 enhanced the expression levels of β-catenin and activation Wnt/β-catenin pathway. Yes While knockout circIFT80 in HT29 cell or SW480 cells, the proliferation, and migration of the cells were inhibited, the cell cycle was arrested in G2/M phase, and the cell apoptosis was increased. 35783013 hsa_circ_0000467 CircRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues and cells Regulation(miR-330-5p-Dependent Regulation of TYRO3) qRT-PCR//IHC//Luciferase Report Assay//RIP Circ_0000467 was a stable circRNA and was highly expressed in CRC tumor tissues and cells. Silencing of circ_0000467 could inhibit the proliferation, migration, invasion, and glycolysis and accelerated the apoptosis of CRC cells in vitro and hindered tumor growth in vivo. Mechanistically, circ_0000467 directly interacted with miR-330-5p and circ_0000467 depletion inhibited CRC cell malignant progression by regulating miR-330-5p. Furthermore, TYRO3 was a target of miR-330-5p and circ_0000467 upregulated TYRO3 expression by sponging miR-330-5p. Moreover, TYRO3 overexpression counteracted the inhibitory effect of miR-330-5p overexpression or circ_0000467 knockdown on CRC cell progression. Altogether, circ_0000467 knockdown suppressed CRC cell malignant development through modulating the miR-330-5p/TYRO3 network, providing a novel molecular target of CRC therapy. Yes Silencing of circ_0000467 could inhibit the proliferation, migration, invasion, and glycolysis and accelerated the apoptosis of CRC cells in vitro and hindered tumor growth in vivo. 35039980 hsa_circ_0039857 LncRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(hsa_circ_0039857/miR-338-3p/RAB32 axis) Western Blot//Transfection//qPCR//PCR//Bioinformatics Analysis//IF This study demonstrated that circ_0039857 knockdown suppressed CRC malignant progression through miR-338-3p/RAB32 axis. Most importantly, this will help us to better understand the circRNA network in CRC, and may find potential biomarkers and targets for CRC clinical treatment. We revealed that circ_0039857 was significantly enhanced in CRC. Circ_0039857 was stabler than linear RNA in cells and valuable for the disease diagnosis. Yes In addition, circ_0039857 knockdown inhibited proliferation and promoted apoptosis. Mechanistically, circ_0039857 positively regulated the expression of RAB32 via sponging miR-338-3p. 36539702 hsa_circ_0022340 CircRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(HNRNPC/EBF1/SYT7 or miR-382-5p/ELK1 axis) qRT-PCR//RIP//Western Blot Results showed that Circ_0022340 was highly expressed in CRC cells. Circ_0022340 was formed from exon 5 to 6 of the synaptotagmin 7 (SYT7). Silencing of circ_0022340 suppressed CRC cell proliferation and migration. Functionally, circ_0022340 recruited heterogeneous nuclear ribonucleoprotein C (HNRNPC) to stabilize EBF1 mRNA and thereby activated SYT7. Moreover, circ_0022340 targeted miR-382-5p to up-regulate ETS transcription factor ELK1 (ELK1). It is concluded that Circ_0022340 promoted colorectal cancer progression via recruiting HNRNPC to stabilize EBF1 mRNA and thereby activated SYT7 or miR-382-5p/ELK1 axis, which might provide a novel target for CRC treatment. Yes Silencing of circ_0022340 suppressed CRC cell proliferation and migration. Functionally, circ_0022340 recruited heterogeneous nuclear ribonucleoprotein C (HNRNPC) to stabilize EBF1 mRNA and thereby activated SYT7. 36495510 hsa_circ_0068464 CircRNA Homo sapiens Colorectal Neoplasms CRC cells and tissues Interaction(miR-383/Wnt/β-catenin pathway) Western Blot//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//Transwell Assay The results revealed that circ_0068464 was abnormally up-regulated in CRC cells and tissues. Further, the binding interaction between circ_0068464 and microRNA-383 (miR-383) was verified by dual-luciferase assay and RNA immunoprecipitation assay. And miR-383 was significantly down-regulated in CRC tissues and cells. Interfering with miR-383 expression reversed the inhibitory effect of circ_0068464 knockdown on CRC cells. In conclusion, circ_0068464 targets miR-383 to regulate Wnt/β-catenin pathway activation, thereby promoting the development of CRC. Yes Knockdown of circ_0068464 could inhibit CRC cell migration and proliferation and promoted apoptosis while suppressing the expression of Wnt/β-catenin pathway-related proteins (β-catenin, cyclin D1, C-myc and LEF-1). In addition, tumorigenic assays in nude mice confirmed that circ_0068464 downregulation significantly inhibited tumor growth and lung metastasis. 35168468 hsa_circ_0084927 CircRNA Homo sapiens Colorectal Neoplasms COAD tissues and cell lines Interaction(has_circ_0084927/miR-106b-5p/VEGFA) CCK8//qRT-PCR Our study found that hsa_circ_0084927 is highly expressed in COAD tissues and cell lines. In addition, we effectively constructed a ceRNA: network has_circ_0084927/miR-106b-5p/VEGFA. Yes Plasma hsa_circ_0084927 can be used as a diagnostic marker for COAD patients; hsa_circ_0084927 can promote the proliferation, migration and invasion of COAD cells. 35493197 hsa_circ_0040809 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-330-3p/RUNX1) qRT-PCR//Bioinformatics Analysis Two DEcircRNAs (hsa_circ_0040809 and hsa_circ_0000467) were identified and validated in CRC tissues and cell lines. The results of MTs and Transwell experiments showed that hsa_circ_0040809 and hsa_circ_0000467 promoted CRC proliferation and migration. Bioinformatics analysis screened 3 miRNAs (miR-326, miR-330-5p, and miR-330-3p) and 2 mRNAs (FADS1 and RUNX1), and a ceRNA network was constructed. In knockdown of hsa_circ_0040809 HCT-116 cells, the expression of miR-330-3p was significantly upregulated, while RUNX1 was significantly downregulated. In knockdown of hsa_circ_0000467 HCT-116 cells, the expressions of miR-326 and miR-330-3p were upregulated, while FADS1was downregulated. Yes Two DEcircRNAs (hsa_circ_0040809 and hsa_circ_0000467) were identified and validated in CRC tissues and cell lines. The results of MTs and Transwell experiments showed that hsa_circ_0040809 and hsa_circ_0000467 promoted CRC proliferation and migration. 36339002 hsa_circ_0006732 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction( miR-127-5p/RAB3D axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Bioinformatics Analysis//Transwell Assay It was found that hsa_circ_0006732 was highly expressed in CRC tissues and cell lines.Further mechanistic investigations proved that hsa_circ_0006732 functioned as a competitive endogenous RNA (ceRNA) by directly sponging of miR-127-3p, which further affected the expression of Ras-related protein Rab-3D (Rab3D). Yes Downregulation of hsa_circ_0006732 suppressed the proliferation, migration, invasion and EMT of CRC cells. 35616807 hsa_circ_0066351 CircRNA Homo sapiens Colorectal Neoplasms CRC cell lines and tissues Expression(lower expressed) qRT-PCR//Colony Formation Assay We proved that hsa_circ_0066351 was significantly downregulated in CRC cell lines and tissues (P < 0.001), and was negatively associated with distant metastasis (P < 0.01). Significantly, the expression of hsa_circ_0066351 was associated with better survival in patients with CRC. Yes Function assays showed that hsa_circ_0066351 could inhibit CRC cells proliferation. 36405685 hsa_circ_0000826 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(AUF1) qRT-PCR//RIP//Western Blot Here, we report that hsa_Circ_0000826 (Circ_0000826), a circRNA with significantly reduced expression level in CRC tissues, is associated with a poor prognosis in patients. Furthermore, Circ_0000826 could target AU-rich element RNA-binding protein 1 (AUF1). AUF1, known as heterogeneous nuclear ribonucleoprotein D (hnRNP D), could bind to the c-MYC 3'-UTR and promote c-MYC expression. When Circ_0000826 binds to AUF1, it competitively inhibits the binding of AUF1 to the c-MYC 3'-UTR, which inhibits the c-MYC expression and cell proliferation. Here, we report that hsa_Circ_0000826 (Circ_0000826), a circRNA with significantly reduced expression level in CRC tissues, is associated with a poor prognosis in patients. T Yes The silencing of Circ_0000826 promotes the proliferation of CRC cells. Conversely, the overexpression of Circ_0000826 restricted CRC cell proliferation both in vitro and in vivo. 35940521 circPTK2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-136-5p/YTHDF1) CCK8//qRT-PCR//RIP//Western Blot In our study, circPTK2 abundance was enhanced in CRC and associated with liver metastasis, clinical stage and chemoresistance. In conclusion, circPTK2 interference suppressed CRC proliferation, migration, invasion and chemoresistance via regulating miR-136-5p and YTHDF1. In our study, circPTK2 abundance was enhanced in CRC and associated with liver metastasis, clinical stage and chemoresistance. Yes CircPTK2 knockdown constrained cell proliferation, migration, invasion, resistance to 5-FU and oxaliplatin, and the Wnt/β-catenin signaling. In addition, we confirmed that circPTK2 silence reduced xenograft tumor growth. 34974791 circIFT80 CircRNA Homo sapiens Colorectal Neoplasms CRC patient serum and CRC cells Interaction(miR-296-5p/MSI1 Axis) qRT-PCR//Luciferase Report Assay//Colony Formation Assay Circ_IFT80 was upregulated in exosomes derived from CRC patient serum and CRC cells. Additionally, circ_IFT80 acted as a sponge of miR-296-5p, and miR-296-5p reversed the effects of circ_IFT80 on tumorigenesis and radiosensitivity. Moreover, MSI1 was a direct target of miR-296-5p. Furthermore, miR-296-5p overexpression inhibited tumorigenesis and promoted radiosensitivity by downregulating MSI1. Yes Exosomal circ_IFT80 or circ_IFT80 overexpression facilitated tumorigenesis by increasing cell proliferation and reducing apoptosis, and inhibited radiosensitivity via promoting colony formation and inhibiting apoptosis. Exosomal circ_IFT80 also accelerated tumor growth in vivo. 33658855 circASS1 CircRNA Homo sapiens Colorectal Neoplasms CRC cells and tissues Interaction(miR-1269a/VASH1 axis) Western Blot//Wound Healing Assay//Tunel//qRT-PCR//MTT//Luciferase Report Assay circASS1 expression was decreased in CRC cells and tissues, and circASS1 overexpression suppressed CRC cell proliferation, invasion and migration. circASS1 adsorbed miR-1269a and regulated its expression, and VASH1 was a target protein of miR-1269a.circASS1 overexpression decreased cell proliferation, invasion and migration, but enhanced cell apoptosis in HT29 cells, which was reversed by co-transfection with miR-1269a mimic or short hairpin RNA-VASH1. Yes circASS1 expression was decreased in CRC cells and tissues, and circASS1 overexpression suppressed CRC cell proliferation, invasion and migration. 34504600 circFAT1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-520b/ UHRF1 Axis or miR-302c-3p/ UHRF1 Axis) CCK8//qRT-PCR//Western Blot The levels of circFAT1 and UHRF1 were increased, as well as the levels of miR-520b and miR-302c-3p were decreased in CRC tissues and cells. Interestingly, circFAT1 was a sponge of miR-520b and miR-302c-3p, and miR-520b and miR-302c-3p could target UHRF1. Both miR-520b overexpression and miR-302c-3p overexpression inhibited CRC cell growth. Furthermore, both miR-520b knockdown and miR-302c-3p depletion weakened the effect of circFAT1 knockdown on the growth of CRC cells. Yes CircFAT1 knockdown suppressed cell proliferation, cycle, and glycolysis as well as induced apoptosis.Besides, circFAT1 depletion repressed tumor growth in vivo. 32379550 circEIF3K CircRNA Homo sapiens Colorectal Neoplasms exosome Interaction(miR-214/PD-L1 axis) CCK8//qRT-PCR//Western Blot We found that hypoxia could induce secretion of circEIF3K exosome. Besides, we observed that circEIF3K knockdown evidently impaired tumor growth in mice. TCGA dataset analysis showed that low expression of circEIF3K was observed in normal tissues and associated with prolonged survival time. Finally, PD-L1 was confirmed as important target for miR-214 in CRC. Besides, we observed that circEIF3K knockdown evidently impaired tumor growth in mice. TCGA dataset analysis showed that low expression of circEIF3K was observed in normal tissues and associated with prolonged survival time. Yes Conditioned medium (CM) and exosome from circEIF3K knockdown CAF significantly attenuated proliferation, invasion and tube formation of HCT116 or SW620 cells, which could be reverted by miR-214 under hypoxia treatment. 34412616 hsa_circ_0101802 CircRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues and cells Interaction(miR-1236-3p/MACC1 axis) CCK8//qRT-PCR//Western Blot Our results showed that circ_0101802 was highly expressed in CRC tumor tissues and cells. In summary, our results revealed that circ_0101802 functioned as a tumor promoter in CRC, which could facilitate CRC proliferation, migration and invasion via regulating the miR-1236-3p/MACC1 axis. Yes Functional experiments suggested that circ_0101802 knockdown could inhibit the proliferation, migration and invasion of CRC cells in vitro and CRC tumorigenesis in vivo. 34294360 circKRT6C CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cells Interaction(miR-485-3p/PDL1 ) In Vivo Experiment//qRT-PCR//Luciferase Report Assay//Western Blot circ-KRT6C was overexpressed in colorectal cancer tissues and cells, and its level was associated with overall survival time of patients with colorectal cancer. circ-KRT6C could increase PDL1 expression by functioning as an miR-485-3p sponge, which promoted malignant progression and immune evasion of colorectal cancer cells. Yes The suppression of circ-KRT6C suppressed growth, migration, invasion, and immune escape while stimulating apoptosis in colorectal cancer cells, which was abolished by shortage of miR-485-3p. In addition, overexpression of miR-485-3p repressed malignant progression and immune evasion of colorectal cancer by targeting PDL1, implying that PDL1 was a functional target of miR-485-3p. A xenograft experiment also suggested that circ-KRT6C inhibition could repress tumor growth in vivo. 33771844 circIL4R CircRNA Homo sapiens Colorectal Neoplasms sera and tissues from CRC patients Interaction(miR-761/TRIM29) qRT-PCR//IHC//ChIP CircIL4R was upregulated in CRC cell lines and in sera and tissues from CRC patients and was positively correlated with advanced clinicopathological features and poor prognosis. Mechanistically, circIL4R was regulated by TFAP2C and competitively interacted with miR-761 to enhance the expression of TRIM29, thereby targeting PHLPP1 for ubiquitin-mediated degradation to activate the PI3K/AKT signaling pathway and consequently facilitate CRC progression. CircIL4R was upregulated in CRC cell lines and in sera and tissues from CRC patients and was positively correlated with advanced clinicopathological features and poor prognosis. Yes Functional experiments demonstrated that circIL4R promotes CRC cell proliferation, migration, and invasion via the PI3K/AKT signaling pathway. 34922544 hsa_circ_0087862 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-142-3p/BACH1 ) CCK8//qRT-PCR//FISH//RIP//ChIP Circ_0087862 was highly expressed in CRC tissues and cell lines. miR-142-3p inhibition weakened the impact of circ_0087862 knockdown on CRC cells. Circ_0087862 regulated BACH1 expressions by targeting miR-142-3p. Circ_0087862 regulates BACH1 expressions through sponging miR-142-3p, and promotes the proliferation, migration, and invasion of CRC cells. Yes Knocking down circ_0087862 significantly restrained the multiplication, migration and invasion of CRC cells. 34390174 circN4BP2L2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-340-5p/CXCR4 axis) CCK8//qRT-PCR//Colony Formation Assay//Western Blot Our data indicated that circN4BP2L2 expression was increased in CRC tissues and cell lines.Mechanistic studies revealed that circN4BP2L2 acted as a molecular sponge of miR-340-5p to competitively promote CXCR4 expression. Furthermore, inhibition of miR-340-5p reversed the anti-cancer effects of circN4BP2L2 or CXCR4 silencing. Yes Notably, inhibition of circN4BP2L2 effectively inhibited proliferation, migration, and invasion of LoVo cells, and inhibited tumor growth and metastasis in vivo, whereas the forced expression of circN4BP2L2 facilitated the proliferation, migration, and invasion of HT-29 cells. 34326457 circMMP1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-1238) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We identified circMMP1 (hsa_circ_0024109) as a frequently upregulated circRNA in both CRC tissues and cells. The results demonstrated that circMMP1 promoted the growth and metastasis of CRC by sponging miR-1238 and upregulating the expression of matrix metalloproteinase 1 (MMP1), MMP2, and MMP9 expression. Yes Both in vitro and in vivo experiments demonstrated that circMMP1 knockdown significantly inhibited the proliferation and metastasis of CRC. 34532478 hsa_circ_0026416 CircRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues and cell lines Interaction( miR-545-3p/MYO6) CCK8//qRT-PCR//Flow Cytometry//Western Blot The expression of circ_0026416 was increased in CRC tumor tissues and cell lines.MiR-545-3p was a target of circ_0026416, and rescue experiments indicated that circ_0026416 knockdown blocked CRC development by enriching miR-545-3p. In addition, miR-545-3p targeted MYO6 and inhibited MYO6 expression. Yes Circ_0026416 downregulation inhibited CRC cell proliferation, colony formation, migration, invasion, and EMT but induced cell apoptosis in vitro, and circ_0026416 knockdown also blocked tumor growth in vivo. 34645476 circRUNX1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-485-5p/SLC38A1 axis) qRT-PCR//Luciferase Report Assay//RIP//Western Blot CircRUNX1 was upregulated in CRC tissues and cells compared with normal tissues and cells. CircRUNX1 directly sponged miR-485-5p, which negatively modulated SLC38A1 expression in CRC cells. Moreover, miR-485-5p overexpression repressed the malignant behaviours of CRC cells, with SLC38A1 elevation overturned the impacts. Yes CircRUNX1 deficiency restrained CRC cell colony formation, migration, invasion and glutaminolysis and induced apoptosis in vitro as well as blocked tumour growth in vivo. The effects of circRUNX1 knockdown on CRC cell colony formation, migration, invasion, apoptosis and glutaminolysis were reversed by miR-485-5p inhibition. 33769559 hsa_circ_3823 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-30c-5p/TCF7 axis) CCK8//qRT-PCR//IHC//IF Circ3823 was evidently highly expressed in CRC and high circ3823 expression predicted a worse prognosis of CRC patients. Mechanism analysis showed that circ3823 act as a competing endogenous RNA of miR-30c-5p to relieve the repressive effect of miR-30c-5p on its target TCF7 which upregulates MYC and CCND1, and finally facilitates CRC progression. Circ3823 was evidently highly expressed in CRC and high circ3823 expression predicted a worse prognosis of CRC patients. Yes Functional experiments in vitro and in vivo indicated that circ3823 promote CRC cell proliferation, metastasis and angiogenesis. 34172072 circPLCE1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(SRSF2/PLCE1 ) qRT-PCR//Bioinformatics Analysis//Western Blot In this study, we found that circPLCE1 was more significantly down-regulated in CRC tissues compared with that in adjacent normal tissues. Mechanistically, circPLCE1 directly bound to the SRSF2 protein, repressing SRSF2-dependent PLCE1 pre-RNA splicing, resulting in the progression of CRC. Individually mutating the binding sites of circPLCE1 abolished the inhibition of PLCE1 mRNA production. Yes However, circPLCE1 knockdown suppressed CRC cell proliferation, migration and invasion and increased apoptosis. Nude mouse experiments showed that ectopic expression of circPLCE1 dramatically increased tumour growth in vivo. 34173324 hsa_circ_0104103 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(HuR and miR-373-5p) RNA Pull-Down//Western Blot//RIP//Luciferase Report Assay//IHC We identified circ0104103, which is strongly downregulated in CRC tissues and cell lines. Mechanistically, circ0104103 binds to HuR, a functional RNA-binding protein commonly expressed in CRC. HuR binds to the 3'UTR of LACTB mRNA to facilitate stabilization and increase its expression. Moreover, circ0104103 was verified as a competing endogenous RNA (ceRNA) via negative regulation of miR-373-5p to increase LACTB expression, resulting in inhibiting the occurrence and progression of CRC. Yes Functional studies revealed that circ0104103 inhibited CRC cell growth, migration, and invasion both in vitro and in vivo. 36562402 hsa_circ_102049 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miRNA-455-3p) qRT-PCR//Luciferase Report Assay The results demonstrated that hsa_circRNA_102049 was highly expressed in both CRC tissues and cell lines, which was associated with enhanced CRC cell proliferation, migration and invasion. Moreover, the results indicated that the circular RNA, hsa_circRNA_102049, may function as a tumor promoter in CRC via directly sponging miRNA-455-3p. Yes The results demonstrated that hsa_circRNA_102049 was highly expressed in both CRC tissues and cell lines, which was associated with enhanced CRC cell proliferation, migration and invasion. 35222721 circLRCH3 CircRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(miRNA-223/LPP Axis) Transwell Assay//qRT-PCR//Luciferase Report Assay//Western Blot We found that the expression level of circLRCH3 was downregulated in CRC cells and negatively correlated with miR-223. In contrast, overexpression of miR-223 and depletion of LPP severally abrogated the tumor suppressive roles of circLRCH3 and miR-223 knockdown in CRC cells in vitro. The xenograft experiments in nude mice also proved the antitumor effect of circLRCH3. Yes The overexpression of circLRCH3 or silencing of miR-223 inhibited the growth, invasion, and migration of CRC cells, but promoted their apoptosis.The xenograft experiments in nude mice also proved the antitumor effect of circLRCH3. 35611368 hsa_circ_0007334 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction( miR-577/KLF12 axis ) qRT-PCR Circ_0007334 and KLF12 were increased, and miR-577 was decreased in CRC tissues and cells.Also, circ_0007334 expression was upregulated in CRC cell-derived exosomes.Mechanically, circ_0007334 could regulate KLF12 expression by sponging miR-577. Yes Circ_0007334 deficiency repressed cell viability, colony formation, migration, invasion, and angiogenesis in CRC cells.Circ_0007334 downregulation or exosomal circ_0007334 silencing blocked CRC tumor growth in vivo. 34459455 hsa_circ_0000467 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-326 and miR-330-3p/FADS1) qRT-PCR//Bioinformatics Analysis Two DEcircRNAs (hsa_circ_0040809 and hsa_circ_0000467) were identified and validated in CRC tissues and cell lines. The results of MTs and Transwell experiments showed that hsa_circ_0040809 and hsa_circ_0000467 promoted CRC proliferation and migration. Bioinformatics analysis screened 3 miRNAs (miR-326, miR-330-5p, and miR-330-3p) and 2 mRNAs (FADS1 and RUNX1), and a ceRNA network was constructed. In knockdown of hsa_circ_0040809 HCT-116 cells, the expression of miR-330-3p was significantly upregulated, while RUNX1 was significantly downregulated. In knockdown of hsa_circ_0000467 HCT-116 cells, the expressions of miR-326 and miR-330-3p were upregulated, while FADS1was downregulated. Yes Two DEcircRNAs (hsa_circ_0040809 and hsa_circ_0000467) were identified and validated in CRC tissues and cell lines. The results of MTs and Transwell experiments showed that hsa_circ_0040809 and hsa_circ_0000467 promoted CRC proliferation and migration. 36339002 circHIPK2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-485-5p/HSP90 ) qRT-PCR//Luciferase Report Assay//Western Blot circHIPK2 expression was upregulated in patients with CRC compared with paracancerous tissues. In contrast, patients with high circHIPK2 expression had lower overall survival rate and disease-free survival rate than those with low circHIPK2 expression.circHIPK2 promoted CRC progression. miR-485-5p reduced CRC progression. miR-485-5p, as the target of circHIPK2 in CRC model, played a role in promoting CRC progression and expediting HSP90 ubiquitination. HSP90 ubiquitination by miR-485-5p can promote cell proliferation. In contrast, patients with high circHIPK2 expression had lower overall survival rate and disease-free survival rate than those with low circHIPK2 expression. Yes circHIPK2 promoted CRC progression. miR-485-5p reduced CRC progression. miR-485-5p, as the target of circHIPK2 in CRC model, played a role in promoting CRC progression and expediting HSP90 ubiquitination. HSP90 ubiquitination by miR-485-5p can promote cell proliferation. 36017914 hsa_circ_0106714 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[Hippo-YAP signaling] Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Transwell Assay Findings revealed that circ0106714 and DLG2 were significantly downregulated, while miR-942-5p was significantly upregulated in human CRC tissues and cell lines. In sum, circ0106714 could suppress CRC by sponging miR-942-5p and releasing DLG2, thus promoting YAP phosphorylation. Yes However, circ0106714 upregulation significantly suppressed tumor progression in vivo and inhibited the malignancy phenotypes of tumor cells in vitro by targeting miR-942-5p. 33128289 circPTK2 CircRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(circPTK2/miR-506-3p/AKT2 axis ) qRT-PCR//MTT//Colony Formation Assay//Western Blot The expressions of circPTK2 and AKT2 were elevated in CRC cells, with a concomitant reduction of miR-506-3p. The circPTK2/miR-506-3p/AKT2 axis plays a novel and essential role in promoting CRC progression, providing potential targets for CRC therapeutic modality. Yes The knockdown of circPTK2 suppressed the proliferation, migration, and invasion of CRC cells. 36156852 hsa_circ_104916 CircRNA Homo sapiens Colonic Neoplasms CRC tissues,cell lines(Caco-2, LoVo, SW480, HT-29 and HCT116) Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Western Blot//Transwell Assay In the present study, we show that circRNA_104916 is Expression[down-expression]regulated in colorectal cancers as compared to the adjacent normal tissues. The expression of circRNA_104916 is negatively correlated with the tumor size, T stage and lymphatic metastasis. Patients with higher relative circRNA_104916 expression have a better post-operative disease-free survival as compared with those with lower relative expression. Yes Additionally, overexpression of circRNA_104916 significantly sExpression[Expression[up-expression]-expression]presses migration and invasion of tumor cells by inhibiting the epithelial-mesenchymal transition. 30844715 hsa_circ_0001038 CircRNA Homo sapiens Colonic Neoplasms CC tissues,cell lines Interaction[activating CNNM3 and MACC1] qRT-PCR//Luciferase Report Assay We found that hsa_circ_0001038 was highly expressed in CC cells and tissues and elevated hsa_circ_0001038 was closely related to the clinical severity including lymph node invasion and myometrial invasion.For mechanism investigation, hsa_circ_0001038 could sponge miR-337-3p to release its suppression on cyclin-M3 (CNNM3) and metastasis-associated in colon cancer 1 (MACC1), thereby promoting CC cell growth and invasive potential, respectively. In conclusion, hsa_circ_0001038 plays an oncogenic role in CC cells partly by activating CNNM3 and MACC1. We found that hsa_circ_0001038 was highly expressed in CC cells and tissues and elevated hsa_circ_0001038 was closely related to the clinical severity including lymph node invasion and myometrial invasion.In addition, overexpressed hsa_circ_0001038 correlated with unfavorable outcome in CC patients. Yes Knockdown of hsa_circ_0001038 attenuated cell growth, migration, and invasion but induced cell apoptosis. 31809842 circPIP5K1A CircRNA Homo sapiens Colonic Neoplasms colon cancer tissue Interaction[inhibiting miR-1273a] qRT-PCR//Transwell Assay//Western Blot CircPIP5K1A was significantly upregulated in colon cancer tissue relative to their adjacent normal tissues.Bioinformatics prediction program predicted that the association of circPIP5K1A with miR-1273a, as well as AP-1, IRF-4, CDX-2, and Zic-1. Subsequent studies showed that overexpression of circPIP5K1A augmented the expression of AP-1 but attenuated the expression of IRF-4, CDX-2, and Zic-1. Reciprocally, overexpression of miR-1273a abrogated the oncogenic function of circPIP5K1A in colon cancers. Yes Knockdown of circPIP5K1A in colon cancer cells impaired cell viability and suppressed cell invasion and migration, while enforced expression of circPIP5K1A exhibited the opposite effects on cell migration. 31558874 hsa_circ_0020095 CircRNA Homo sapiens Colonic Neoplasms CC tissues and cells regulation[miR-487a-3p/SOX9 axis] qRT-PCR We demonstrated that circ_0020095 was highly expressed in CC tissues and cells. Circ_0020095 functions as an oncogene to accelerate CC cell proliferation, invasion, migration and cisplatin resistance through the miR-487a-3p/SOX9 axis, which could be a promising target for CC treatment. Yes The proliferation, migration, invasion, and cisplatin resistance of CC were suppressed by silencing circ_0020095 in vitro and in vivo or by ectopic expression of miR-487a-3p in vitro. 33520987 hsa_circ_100859 CircRNA Homo sapiens Colonic Neoplasms colon cancer tissues regulation[miR-217-HIF-1α pathway] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay It was identified that circRNA_100859 was overexpressed in colon cancer tissues and promoted cell proliferation and inhibited cell apoptosis. In addition, the circRNA_100859-miR-217-HIF-1α axis may serve as a novel diagnostic and prognostic biomarker for patients with colon cancer. Yes It was identified that circRNA_100859 was overexpressed in colon cancer tissues and promoted cell proliferation and inhibited cell apoptosis. 32644049 hsa_circ_000166 CircRNA Homo sapiens Colonic Neoplasms CC tissue and cell lines regulation[miR-330-5p/ELK1] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay hsa_circRNA_000166 was significantly upregulated in the human CC tissue and in the CC cell lines.The data of this study demonstrated that the hsa_circRNA_000166 could upregulated the expression of gene ELK1 by sponging miR-330-5p, which may contribute to a better understanding of the regulatory circRNA/miRNA/mRNA network and CC pathogenesis. Yes Knockdown of hsa_circRNA_000166 reduced cell viability, colony formation, migration and invasion in vitro and decreased tumor size and weight in vivo. 32606768 circFNDC3B CircRNA Homo sapiens Colonic Neoplasms CC cell lines and tissues regulation[Snail] Wound Healing Assay//CCK8//qRT-PCR//FISH//Transwell Assay CircFNDC3B was localized mostly in the cytoplasm, and was decreased in CC cell lines and tissues.By RNA-sequencing, western blot and glucose metabolism-related assays, we found that circFNDC3B-218aa inhibited the expression of Snail, and subsequently promoted the tumor-suppressive effect of FBP1 in CC. The patients with low circFNDC3B expression had a shorter OS (P = 0.0014) than patients with high expression. Yes Moreover, circFNDC3B inhibited the proliferation, invasion and migration of CC cells. 32241279 hsa_circ_0001313 CircRNA Homo sapiens Colonic Neoplasms colon cancer tissues and cell lines regulation[Circ-0001313/miRNA-510-5p/AKT2 axis ] Flow Cytometry//qRT-PCR//Luciferase Report Assay//EdU Staining Consistent with the microarray analysis, circ-0001313 was highly expressed in colon cancer tissues and cell lines. In conclusion, our study revealed that circ-0001313 regulates the pathogenesis of colon cancer by sponging miRNA-510-5p to upregulate AKT2 expression. Yes Knockdown of circ-0001313 attenuated proliferative ability, but induced apoptosis of colon cancer cells. 32051753 circSMARCA5 CircRNA Homo sapiens Colonic Neoplasms colon cancer tissues Interaction(miR-552) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Our data presented that circSMARCA5 was under-expressed in colon cancer tissues. Yes Transfection with overexpressing circSMARCA5 plasmid restrained growth, migration and invasion of colon cancer cells. 33749508 circPPP1R12A CircRNA Homo sapiens Colonic Neoplasms CC tissues and cells Interaction(miR-375/CTNNB1 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay Our results showed that circPPP1R12A was a highly expressed circRNA in CC tissues and cells. MiR-375 could be sponged by circPPP1R12A, and its inhibitor could reverse the inhibition of circPPP1R12A silencing on CC progression. Furthermore, CTNNB1 was a target of miR-375, and its overexpression also abolished the suppression of miR-375 on CC progression. Moreover, circPPP1R12A indirectly regulated CTNNB1 expression by sponging miR-375. Yes Silenced circPPP1R12A suppressed the proliferation, promoted the apoptosis, and inhibited the migration and invasion of CC cells. MiR-375 could be sponged by circPPP1R12A, and its inhibitor could reverse the inhibition of circPPP1R12A silencing on CC progression. 33595945 hsa_circ_0038718 CircRNA Homo sapiens Colonic Neoplasms CC tumor Interaction(miR-195-5p/Axin2/Wnt/β-catenin signaling pathway) qRT-PCR//Transwell Assay//RIP//Western Blot circ_0038718 was highly expressed in CC and could sponge miR-195-5p in cytoplasm. Axin2 was a downstream target of miR-195-5p and could regulate the Wnt/β-catenin signaling pathway. Axin2 expression was modulated by circ_0038718/miR-195-5p. Yes Silencing circ_0038718 suppressed the proliferative, migratory and invasive abilities of CC cells, while the promoting effect of high circ_0038718 expression on CC cells was reversed upon miR-195-5p over-expression. 34706645 hsa_circ_0085315 CircRNA Homo sapiens Colonic Neoplasms CC patients Interaction(miR-1200/MAP3K1 signaling pathway) qRT-PCR//Luciferase Report Assay//Colony Formation Assay Our results showed that the higher circRNA_0085315 expression led to the poorer prognosis of CC patients. In conclusion, circRNA_0085315 serves as a ceRNA and promotes CC progression through the activation of the MAPK signaling pathway mediated via the miR-1200/MAP3K1 axis, suggesting that circRNA_0085315 may be a promising diagnostic and therapeutic target for CC. Yes MAP3K1-overexpression or miR-1200 mimics prevented the suppression on the enhanced cell proliferation, migration, and invasion caused by circRNA_0085315-overexpression. circRNA_0085315 increased the phosphorylation levels of JNK, p38, and ERK1/2 by stimulating MAP3K1 up-regulation caused by miR-1200 inhibition. 35230926 circHADHA CircRNA Homo sapiens Colonic Neoplasms colon cancer cells and tissues Interaction( miR-361/ATG13) qRT-PCR//Luciferase Report Assay//Tunel We explored that circRNA HADHA (circHADHA) was upregulated in plasma from polyp patients, whereas it was downregulated in plasma from colon cancer patients.CircHADHA increased the expression of ATG13 via miR-361 in both colon epithelial and cancer cells. ATG13 knockdown reduced autophagy even in the presence of circHADHA in colon cancer cells. Yes Overexpression of circHADHA promoted autophagy in colon epithelial cells. Moreover, in colon cancer cells, overexpression of circHADHA promoted autophagy, whereas it inhibited cell proliferation and colony formation. 36313671 circPPFIA1s CircRNA Homo sapiens Colonic Neoplasms KM12L4 cells Interaction(miR-155-5p/CDX1 and HuR/RAB36) qRT-PCR//RIP By analyzing circRNA microarray data, we identified two anti-metastatic circRNAs generated from PPFIA1 with different length, which named circPPFIA1-L (long) and -S (short). They were significantly downregulated in liver metastatic KM12L4 cells compared to primary KM12C cells. circPPFIA1s were found to function as sponges of oncogenic miR-155-5p and Hu antigen R (HuR) by an ASO pulldown experiment. circPPFIA1s upregulated tumor-suppressing CDX1 expression and conversely downregulated oncogenic RAB36 by decoying miR-155-5p and by sequestering HuR, respectively. Yes knockdown of circPPFIA1s in KM12C enhanced metastatic potential and increased liver metastasis. Conversely, overexpression of circPPFIA1s weakened metastatic potential and inhibited liver metastasis. 36224588 circCSPP1 CircRNA Homo sapiens Colonic Neoplasms colon cancer tissues and cell lines Interaction(miR-431/ROCK1 and miR-431/ZEB1) qRT-PCR//RIP//Western Blot It was found that circCSPP1 expression was significantly upregulated in colon cancer tissues and cell lines. Mechanistically, circCSPP1 was found to bind with miR-431. In addition, ROCK1 and ZEB1 were identified as the target genes of miR-431. Rescue experiments further confirmed the interaction between circCSPP1, miR-431, ROCK1 and ZEB1. Moreover, circCSPP1 promoted the expression level of ROCK1, cyclin D1, cyclin-dependent kinase 4, ZEB1 and Snail, and lowered the E-cadherin expression level. Yes Overexpression of circCSPP1 significantly promoted the proliferation, migration and invasion of colon cancer cells, whereas silencing of circCSPP1 exerted opposite effects 35101080 circABCB10 CircRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues Interaction[negatively regulated miR-1271, miR-1252 and miR-203] qRT-PCR Circ-ABCB10 was upregulated in tumor tissues compared with adjacent tissues, and presented with good value in distinguishing tumor tissues from adjacent tissues (AUC = 0.766, 95% CI: 0.690-0.842). Circ-ABCB10 high expression was correlated with poor differentiation, large tumor size and advanced International Federation of Gynecology and Obstetrics (FIGO) stage in EOC patients. As for survival, circ-ABCB10 was correlated with worse OS. Yes In vitro experiments revealed that circ-ABCB10 was upregulated and promoted cell proliferation but reduced cell apoptosis, and negatively regulated miR-1271, miR-1252 and miR-203 in EOC cells. 31381507 circMUC16 CircRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues interaction[ATG13 and miR-199a] Western Blot//qRT-PCR//FISH//RNA-seq//IHC CircMUC16 had increased expression in EOC tissues as compared to healthy ovarian tissues. This study demonstrated that circMUC16 regulated Beclin1 and RUNX1 by sponging miR-199a-5p. The data suggested that circMUC16 could be a potential target for EOC diagnosis and therapy. The expression of circMUC16 was linked to the progression in stage and grade of EOC. Yes Hence, silencing circMUC16 suppressed autophagy flux of SKOV3 cells. In contrast, ectopic expression of circMUC16 promoted autophagy flux of A2780 cells. 32111227 hsa_circ_0072995 CircRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissue samples and cell lines regulation[miR-147a/CDK6 axis] qRT-PCR//Luciferase Report Assay//Western Blot Circ_0072995 was up regulated in EOC afflicted tissues and cell lines (HO8910 and A2780), and was mainly located in the cytoplasm. Our results revealed that circ_0072995 promoted EOC progression through the circ_0072995/miR-147a/CDK6 axis and may represent a strategy for treatment of EOC afflicted patients. The expression of circ_0072995 was associated with the pathological grade of EOC for respective patients. Yes Functional experiments revealed that circ_0072995 promoted EOC cell proliferation, migration, induced apoptosis, as well as enhanced tumorigenesis in vivo. 32877369 circPPP1R12A CircRNA Homo sapiens Colonic Neoplasms CC tissues,cell lines(cell lines HT-29, HCT-116, SW480, SW620, LoVo, SW48, DLD-1, Caco2 and HCT-15,NCM460) Interaction[Hippo-YAP signaling ] qRT-PCR//FISH//Western Blot//Microarray We firstly screened the expression profiles of human circRNAs in CC tissues and found that the expression of hsa_circ_0000423 (termed as circPPP1R12A) was significantly increased in CC tissues. Moreover, we identified that circPPP1R12A-73aa promoted the tumor pathogenesis and metastasis of CC via activating Hippo-YAP signaling pathway. Kaplan-Meier analysis showed that patients with higher levels of circPPP R 2A had a significantly shorter overall survival. Yes By gain- and loss-of-function approaches, the results suggested that circPPP1R12A played a critical role in proliferation, migration and invasion of CC cells. 30925892 hsa_circ_0003602 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-149-5p/SLC38A1 Axis) Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay Circ_0003602 was upregulated in CRC tissues and cell lines. Moreover, circ_0003602 directly interacted with miR-149-5p to negatively regulate its expression, and circ_0003602 knockdown suppressed the malignant behaviors of CRC cells largely by upregulating miR-149-5p. MiR-149-5p directly bound to the 3' untranslated region of SLC38A1 to induce its degradation, and miR-149-5p overexpression reduced the malignant potential of CRC cells largely by downregulating SLC38A1. Circ_0003602 positively regulated SLC38A1 expression by sponging miR-149-5p in CRC cells. Yes Circ_0003602 silencing suppressed CRC cell viability, migration, invasion, angiogenesis, and glutaminolysis; induced cell apoptosis in vitro; and blocked tumor growth in vivo. 36148577 circZC3HAV1 CircRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(miR-146b-3p/TBC1D9 ) Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay circZC3HAV1 was significantly downregulated in CRC cells. As for the mechanism, circZC3HAV1 competitively bound with microRNA-146b-3p (miR-146b-3p) to enhance the expression of TBC1 domain family member 9 (TBC1D9). Rescue assays demonstrated circZC3HAV1 sponged miR-146b-3p and upregulated TBC1D9 to restrict migration and invasion of CRC cells. Yes circZC3HAV1 overexpression hampered CRC cell migratory and invasive abilities. 36164444 hsa_circ_0101802 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-665/DVL3 Signaling) qRT-PCR//Luciferase Report Assay//RIP The expression of DVL3 and circ_0101802 was elevated in CRC tissues and cell lines, and high levels of DVL3 and circ_0101802 were closely associated with short survival time of CRC patients. miR-665 was an intermediary molecule between circ_0101802 and DVL3, and circ_0101802 could positively regulate DVL3 protein expression by sponging miR-665 in CRC cells. DVL3 overexpression partly overturned miR-665 overexpression-mediated anti-tumor effects in CRC cells. The expression of DVL3 and circ_0101802 was elevated in CRC tissues and cell lines, and high levels of DVL3 and circ_0101802 were closely associated with short survival time of CRC patients. Yes Circ_0101802 silencing restrained the proliferation, migration, and tube formation abilities and induced the apoptosis of CRC cells. Circ_0101802 silencing-induced anti-tumor effects in CRC cells were partly reversed by DVL3 overexpression. Circ_0101802 knockdown significantly suppressed xenograft tumor growth in vivo. 35314912 circEXOC6B CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation(HIF1A-RRAGB-mTORC1) RNA Pull-Down//ChIP//CCK8//qRT-PCR//FISH//RIP//IF circEXOC6B was downregulated in CRC tissues, and its lower expression was associated with poor prognosis of patients. Mechanistically, circEXOC6B inhibited the heterodimer formation of RRAGB by binding to it, thereby suppressing the mTORC1 pathway and HIF1A level. In addition, HIF1A upregulated the transcription of RRAGB by binding to its promoter region. Altogether, the results demonstrated that a HIF1A-RRAGB-mTORC1 positive feedback loop drives tumor progression in CRC, which could be interrupted by circEXOC6B. Yes Functional experiments showed that circEXOC6B inhibited growth and increased the 5-fluorouracil-induced apoptosis of CRC cells in vitro and in vivo. 35739524 circIGF1R CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-362-5p/HMGB3-Mediated Wnt/β-Catenin Signal Pathway) CCK8//qRT-PCR//RIP//IHC//Transwell Assay Circ-IGF1R was up-regulated in CRC tissues and cells.Circ-IGF1R interacted with miR-362-5p and miR-362-5p inhibitor attenuated the anti-tumor effects of circ-IGF1R downregulation on CRC cells. HMGB3 acted as a downstream target for miR-362-5p, and circ-IGF1R facilitated the malignant behaviors of CRC cells by regulating HMGB3. Circ-IGF1R activated the Wnt/β-catenin pathway via targeting miR-362-5p/HMGB3 axis. Yes Knockdown of circ-IGF1R inhibited proliferation, migration, invasion and glycolysis but induced apoptosis of CRC cells. Tumor growth in vivo was reduced after knockdown of circ-IGF1R. 36542208 circREEP3 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(circREEP3-FKBP10 axis) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//ELISA Here, circREEP3 is found to be upregulated in CRC tissues. Mechanistically, circREEP3 recruits the chromatin remodeling protein CHD7 to FKBP10 promoter and activates its transcription. Moreover, circREEP3 restricts RIG-1-dependent antitumor immunity. FKBP10 is highly expressed in CRC tissues and associated with poor prognosis. FKBP10 ectopic expression partially rescues the potential of proliferation and metastasis in circREEP3-deficient CRC cells. circREEP3 upregulation predicts poor patient survival. Yes circREEP3 knockout suppresses CRC tumorigenesis and metastasis, and impairs stem cell-like phenotype. 35233964 hsa_circ_0001955 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-583/FGF21 Axis) RNA Pull-Down//Tunel//CCK8//qRT-PCR//FISH We found that hsa_circ_0001955 showed characteristics of upregulated circRNA in CRC. Furthermore, hsa_circ_0001955 was a miR-583 sponge and FGF21 was directly targeted by miR-583. In addition, we found that downregulation of miR-583 promoted hsa_circ_0001955-mediated CRC cell malignancy in vitro. In contrast, FGF21 elevation promoted miR-583-regulated CRC cell malignancy in vitro. Yes Further analysis indicated that hsa_circ_0001955 elevation facilitated CRC cell malignancy in vitro and promoted tumor growth in vivo. 35602296 hsa_circ_0000375 CircRNA Homo sapiens Colorectal Neoplasms clinical CRC tissue and serum samples and CRC cell lines Interaction(miR-1182) qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Transwell Assay Downregulated circ_0000375 and circ_0011536 expression was observed in CRC tissues in GSE126095, clinical CRC tissue and serum samples and CRC cell lines. Furthermore, miR-1182 and miR-1246, which were overexpressed in CRC tissues in GSE41655, GSE49246 and GSE115513, were verified as target miRNAs of circ_0000375 and circ_0011536, respectively, by luciferase reporter assays. Yes Circ_0000375 and circ_0011536 overexpression inhibited the proliferation, migration and invasion of CRC cells. 35611198 hsa_circ_0011536 CircRNA Homo sapiens Colorectal Neoplasms clinical CRC tissue and serum samples and CRC cell lines Interaction(miR-1246) qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Transwell Assay Downregulated circ_0000375 and circ_0011536 expression was observed in CRC tissues in GSE126095, clinical CRC tissue and serum samples and CRC cell lines. Furthermore, miR-1182 and miR-1246, which were overexpressed in CRC tissues in GSE41655, GSE49246 and GSE115513, were verified as target miRNAs of circ_0000375 and circ_0011536, respectively, by luciferase reporter assays. Yes Circ_0000375 and circ_0011536 overexpression inhibited the proliferation, migration and invasion of CRC cells. 35611198 circFNDC3B CircRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(FXR2/RNF41) qRT-PCR//Wound Healing Assay//RNA Pull-Down//Western Blot Mechanistically, studies revealed that YTHDC1 facilitated cytoplasmic translocation of m6A-modified circFNDC3B, and circFNDC3B enhanced RNF41 mRNA stability and expression via binding to FXR2. circFNDC3B promoted ASB6 degradation through RNF41-mediated ubiquitination. Functional studies showed that silencing of RNF41 counteracted circFNDC3B-suppressed CRC stemness and metastasis, and ASB6 overexpression reversed circFNDC3B- or RNF41-mediated regulation of CRC stemness and metastasis. Downregulated circFNDC3B was associated with unfavorite survival in CRC patients, and circFNDC3B overexpression suppressed CRC stemness and metastasis. Yes Downregulated circFNDC3B was associated with unfavorite survival in CRC patients, and circFNDC3B overexpression suppressed CRC stemness and metastasis. 36446779 hsa_circ_0000231 CircRNA Homo sapiens Colorectal Neoplasms CRC primary tissues and cells Interaction(miR-375/IGF2BP3/CCND2) qRT-PCR//RNA Pull-Down//Western Blot We acquired data through circRNA microarray profiles, showing that the expression of hsa_circ_0000231 was upregulated in CRC primary tissues compared to adjacent normal tissues, which was indicated poor prognosis of patients with CRC. The mechanistic analysis showed that hsa_circ_0000231 might, on the one hand, act as a competing endogenous RNA of miR-375 to promote cyclin D2 (CCND2) and, on the other hand, bind to the IGF2BP3 protein to prevent CCND2 degradation. We acquired data through circRNA microarray profiles, showing that the expression of hsa_circ_0000231 was upregulated in CRC primary tissues compared to adjacent normal tissues, which was indicated poor prognosis of patients with CRC. Yes Functional analysis indicated that inhibition of hsa_circ_0000231 in CRC cell lines could suppress CRC cell proliferation as well as tumorigenesis in vitro and in vivo. 35033075 circLDLR CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-30a-3p/SOAT1 axis) qRT-PCR//RIP//FISH In our study, high expression of circLDLR was found in CRC tissues and cells and was closely associated with the malignant progression and poor prognosis of CRC patients. Mechanistically, we showed that circLDLR competitively binds to miR-30a-3p and prevents it from reducing the SOAT1 level, facilitating the malignant progression of CRC. In our study, high expression of circLDLR was found in CRC tissues and cells and was closely associated with the malignant progression and poor prognosis of CRC patients. Yes We demonstrated that circLDLR boosts growth and metastasis of CRC cells in vitro and in vivo, and modulates cholesterol levels in vitro. 35821230 hsa_circ_0001666 CircRNA Homo sapiens Colorectal Neoplasms HT-29 and HCT-116 cell lines Interaction(microRNA-1229/ Wnt/β-catenin signaling pathway ) Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot In addition, circ_0001666 expression levels negatively regulated those of miR-1229, whereas miR-1229 expression did not affect circ_0001666, in both the HT-29 and HCT-116 cell lines. Furthermore, a luciferase reporter assay confirmed that miR-1229 directly bound to circ_0001666. In the HT-29 cell line, miR-1229 overexpression activated the Wnt/β-catenin pathway, and promoted cell proliferation, invasion and stemness, while suppressing cell apoptosis. In addition, miR-1229 overexpression reversed the effects of circ_0001666 overexpression. Yes The protein expression level of proteins in the Wnt/β-catenin pathway was also examined. In both HT-29 and HCT-116 cell lines, circ_0001666 overexpression increased apoptosis, whilst inhibiting cell proliferation and invasion, and reducing the frequency of CD133+ cells. By contrast, circ_0001666 knockdown reduced apoptosis, but increased cell proliferation and the number of CD133+ cells. However, cell invasion remained unaffected. 35836485 circTMEM59 CircRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues and cells Interaction( miR-410-3p/HOXD8 axis) RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Transwell Assay CircTMEM59 was lowly expressed in CRC tumor tissues and cells. MiR-410-3p could be sponged by circTMEM59, and its mimic also reversed the inhibition effect of circTMEM59 on CRC cell proliferation and metastasis. Also, HOXD8 was targeted by miR-410-3p, and its knockdown abolished the negative regulation of miR-410-3p inhibitor on CRC cell proliferation and metastasis. Furthermore, circTMEM59 inhibited CRC tumor growth by overexpressing HOXD8 through sponging miR-410-3p. Yes Upregulation of circTMEM59 repressed CRC cell proliferation, migration and invasion. 35426617 hsa_circ_0045932 CircRNA Homo sapiens Colorectal Neoplasms CRC tissue samples and cells Interaction(miR-873-5p/HK2 ) qRT-PCR//Luciferase Report Assay//RIP//Western Blot Hsa_circ_0045932 was overexpressed in CRC tissue samples and cells.vHK2 was targeted by miR-873-5p, and hsa_circ_0045932 regulated HK2 expression through targeting miR-873-5p. Overexpression of HK2 reversed the repressive effect of hsa_circ_0045932 knockdown on CRC cell malignant behaviors. Yes Hsa_circ_0045932 knockdown repressed CRC cell proliferation, invasion, migration, and glycolysis abilities in vitro. MiR-873-5p could be sponged by hsa_circ_0045932, and its inhibitor also reversed the inhibitory effect of hsa_circ_0045932 knockdown on CRC cell progression. Furthermore, the pro-tumor role of hsa_circ_0045932 in vivo was also confirmed using animal experiments. 35949038 circPITHD1 CircRNA Homo sapiens Colorectal Neoplasms CRC cell line and tissues Interaction(miR-590-5p/HK2 Axis) In Vivo Experiment//qRT-PCR//Luciferase Report Assay The data showed that circ-PITHD1 expression increased in a CRC cell line and tissues, which indicated that circ-PITHD1 functioned in CRC progression. Luciferase reporter results confirmed that both miR-590-5p and hexokinase 2 (HK2) were circ-PITHD1 downstream targets. HK2 overexpression or miR-590-5p suppression reversed CRC cell proliferation and invasion after silencing of circ-PITHD1 by regulation of glycolysis. Yes circ-PITHD1 downregulation inhibited CRC invasion and proliferation in the experiments. 36276867 hsa_circ_0052184 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer cell lines and tissues Interaction(miR-604/HOXA9 Axis) qRT-PCR//Luciferase Report Assay//Western Blot Expression of circ_0052184 was significantly increased in colorectal cancer cell lines and tissues. miR-604 was targeted by circ_0052184. The downstream target of miR-604 was HOXA9, and silencing circ_0052184 inhibited HOXA9 expression. The existence of the circ_0052184/miR-604/HOXA9 regulatory network in colorectal cancer was validated. circ_0052184 promoted the occurrence and development of colorectal cancer by targeting the miR-604/HOXA9 axis. Yes Silencing circ_0052184 affected the proliferation, migration, and invasion of colorectal cancer cells. 36065412 circFADS2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-498/S100A16) qRT-PCR//Western Blot//Cell Cycle Assay//Transwell Assay circ-FADS2 was found to be significantly upregulated in CRC tissues, when compared with paired normal tissues. By inhibiting miR-498 expression, circ-FADS2 promoted S100A16 expression leading to the activation of the AKT pathway, resulting in CRC progression. Higher circ-FADS2 expression was associated with advanced stages, lymphatic metastasis, and reduced overall survival (OS). Yes In addition, silencing circ-FADS2 markedly inhibited the proliferation and invasion of CRC and increased the percentage of cancer cells in the G1 phase in vitro. Reducing circ-FADS2 decreased SW480 cell proliferation in vivo. 36696241 hsa_circ_0003215 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-663b/DLG4/G6PD axis) CCK8//qRT-PCR//RNA Pull-Down//Transwell Assay The novel circ_0003215 was identified at low levels in CRC and was negatively correlated with larger tumor size, higher TNM stage, and lymph node metastasis. The decreased level of circ_0003215 was resulted from the RNA degradation by m6A writer protein YTHDF2. Moreover, circ_0003215 regulated the expression of DLG4 via sponging miR-663b, thereby inducing the metabolic reprogramming in CRC. Mechanismly, DLG4 inhibited the PPP through the K48-linked ubiquitination of glucose-6-phosphate dehydrogenase (G6PD). The novel circ_0003215 was identified at low levels in CRC and was negatively correlated with larger tumor size, higher TNM stage, and lymph node metastasis. Yes A series of functional assays demonstrated that circ_0003215 inhibited cell proliferation, migration, invasion, and CRC tumor metastasis in vivo and in vitro. 36127319 circTMEM59 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-668-3p/ID4 Axis) Western Blot//Tunel//qRT-PCR//FISH//RIP This research primarily revealed that circTMEM59 was greatly downregulated in CRC tissues and cell lines via qRT-PCR. Furthermore, circTMEM59 also repressed the metastatic behaviors of CRC cells. Further study revealed that circTMEM59 played the role of competing endogenous RNAs (ceRNAs) by binding to miR-668-3p to increase the expression of inhibitor of DNA binding 4 (ID4) in CRC. In addition, the decreased expression of circTMEM59 was closely related to adverse clinicopathological characteristics and the shorter survival time of CRC patients. Yes Then, a further study found that the overexpression of circTMEM59 suppressed cell growth and accelerated the cell death of CRC via a series of experiments in vitro and in vivo. 35656024 hsa_circ_0001535 CircRNA Homo sapiens Colorectal Neoplasms colorectal tissues and cells Interaction(miR-485-5p/LASP1 Axis ) qRT-PCR//Western Blot Circ_0001535 was significantly upregulated in colorectal tissues and cells. This knockdown also induced apoptosis by sponging miR-485-5p and upregulating LASP1 expression. Yes Circ_0001535 knockdown suppressed the malignant behavior of colorectal cells such as proliferation, invasion, stemness, and tumor growth in vivo. 36172827 circFAT1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-619-5p/FOSL2) Flow Cytometry//qRT-PCR//Transwell Assay//Western Blot Circ-FAT1 and FOSL2 were highly expressed in CRC tissues and cells. Mechanistically, circ-FAT1 acted as a sponge for miR-619-5p to up-regulate the expression of FOSL2, which was confirmed to be a target of miR-619-5p. A series of rescue experiments demonstrated that miR-619-5p inhibition or FOSL2 overexpression reversed the inhibitory action of circ-FAT1 silencing on CRC cell malignant phenotypes mentioned above. Yes Functionally, knockdown of circ-FAT1 or FOSL2 suppressed CRC cell apoptosis, migration, invasion, and angiogenesis, but induced cell apoptosis in vitro. Pre-clinically, lentivirus-mediated circ-FAT1 knockdown inhibited the tumorigenesis of CRC xenografts in nude mice via regulating miR-619-5p and FOSL2. 35034245 circFAM120B CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-645/TGFBR2) RNA Pull-Down//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of circFAM120B was decreased in CRC tissues and cells. MiR-645 was a target of circFAM120B, and miR-645 restoration reversed the effects of circFAM120B overexpression. In addition, TGFBR2 was a target of miR-645, and miR-645 inhibition-suppressed CRC cell proliferation, migration/invasion and glycolysis were restored by TGFBR2 knockdown. Moreover, circFAM120B activated the expression of TGFBR2 by targeting miR-645. TGFBR2 also blocked tumor growth in vivo by targeting the miR-645/TGFBR2 axis. Yes CircFAM120B overexpression blocked CRC cell proliferation, migration/invasion, and glycolysis metabolism. 34381772 hsa_circ_0029803 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction( miR-216b-5p/SKIL axis.) qRT-PCR//IHC//Luciferase Report Assay//Western Blot Circ_0029803 expression was enhanced in CRC tissues and cells, and the 5-year overall survival rate of patients with high circ_0029803 expression was substantially reduced. Mechanically, circ_0029803 could serve as miR-216b-5p sponge to regulate its expression, and miR-216b-5p knockdown reversed the inhibition of si-circ_0029803 on the malignant behaviors of CRC cells. Additionally, as the target mRNA of miR-216b-5p, SKIL could counteract the inhibitory effect of miR-216b-5p on the development of CRC cells. Circ_0029803 expression was enhanced in CRC tissues and cells, and the 5-year overall survival rate of patients with high circ_0029803 expression was substantially reduced. Yes Circ_0029803 depletion retarded proliferation, migration, invasion, EMT and glycolysis of CRC cells in vitro as well as the tumor growth in vivo. 34479589 circCOG2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues, plasmas, and exosomes Interaction(miR-1305/TGF-β2/SMAD3 pathway) CCK8//qRT-PCR//Colony Formation Assay//Western Blot We found that circCOG2 was increased in CRC tissues, plasmas, and exosomes. Upregulated circCOG2 promoted CRC proliferation, migration, and invasion through the miR-1305/TGF-β2/SMAD3 pathway, and this effect could be transmitted from CRC cells with the high metastatic potential to CRC cells with low metastatic potential by exosomes. Yes Upregulated circCOG2 promoted CRC proliferation, migration, and invasion through the miR-1305/TGF-β2/SMAD3 pathway, and this effect could be transmitted from CRC cells with the high metastatic potential to CRC cells with low metastatic potential by exosomes. 34635639 hsa_circ_0008285 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-382-5p/PTEN axis] qRT-PCR//Luciferase Report Assay//Western Blot First, the downregulated expression of circ_0008285 in CRC tissues and cell lines was confirmed using RT-qPCR analysis. Mechanistically, by using RNA-sequencing, bioinformatics analysis, dual-luciferase reporter assay, and western blotting, we determined that circ_0008285 suppressed the PI3K/AKT pathway via the miR-382-5p/PTEN axis. In addition, the expression level of circ_0008285 was inversely correlated with tumor size, lymphatic metastasis, and tumor-node-metastasis (TNM) stage through clinicopathological parameter analysis. Yes Functionally, knockdown of circ_0008285 promoted CRC cell proliferation and migration in vitro. 32423803 hsa_circ_0056618 CircRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues and CRC cell lines regulation[miR-206,CXCR4,VEGF-A] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that circ_0056618 was elevated in CRC tumor tissues and CRC cell lines, which was related to poor diagnosis for CRC patients. We found that circ_0056618 could promote cell proliferation, migration and angiogenesis through sponging with miR-206 and upregulating CXCR4 and VEGF-A in CRC, which might provide a novel potential therapeutic target for treating CRC. We found that circ_0056618 was elevated in CRC tumor tissues and CRC cell lines, which was related to poor diagnosis for CRC patients. Yes Circ_0056618 inhibition inhibited proliferation, angiogenesis and migration of HT29 cells, and repressed protein levels of Cyclin D1, VEGF-A and N-cadherin and increased E-cadherin. 32373955 circAPLP2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[miR-485-5p/FOXK1 Axis] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay circAPLP2 expression was enhanced in CRC tissues and cells.circAPLP2 knockdown inhibited CRC progression through regulating miR-485-5p/FOXK1 axis, providing a novel avenue for treatment of CRC. Yes circAPLP2 knockdown or miR-485-5p overexpression suppressed cell proliferation, migration, and invasion, whereas it promoted apoptosis in CRC cells, which was reversed by upregulating FOXK1. 32343603 hsa_circ_0060745 CircRNA Homo sapiens Colorectal Neoplasms CRC tissue regulation[Circ_0060745/miR-4736/CSE1L axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC We showed that circ_0060745 was upregulated in CRC, and was associated with unfavorable clinicopathological characteristics.The Circ_0060745/miR-4736/CSE1L axis might be a novel target for the treatment of CRC. Yes We also showed that circ_0060745 acted as an oncogene and promoted CRC cell proliferation and metastasis. 32273712 hsa_circ_101951 CircRNA Homo sapiens Colorectal Neoplasms CRC tissue and cell lines regulation[ KIF3A-mediated EMT pathway] Western Blot//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay The results indicated that circRNA_101951 was increased in CRC tissues and cell lines.In addition, the downregulation of circRNA_101951 blocked the KIF3A-mediated epithelial-mesenchymal transition (EMT) pathway, which was detected by examining the expression levels of KIF3A and EMT related proteins. Yes The downregulation of circRNA_101951 inhibited cell proliferation and colony formation as well as cell migration and invasion of CRC cell lines. 32266033 circVAPA CircRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues regulation[miR-125a/CREB5 axis] Flow Cytometry//qRT-PCR//RIP//Transwell Assay CircVAPA level was up-regulated in CRC tumor tissues.Our studies disclosed that circVAPA knockdown suppressed CRC cells cycle progression, migration, invasion and glycolysis partly by modulating miR-125a/CREB5 axis, suggesting a potential therapeutic strategy for CRC treatment. Yes CircVAPA knockdown repressed CRC cells cycle progression, migration, invasion and glycolysis. 32256212 circDENND4C CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cells regulation[miR-760/GLUT1 axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot The expression of circDENND4C and GLUT1 was upregulated in colorectal cancer tissues and cells. CircRNA circDENND4C accelerated proliferation, migration, and glycolysis of colorectal cancer cells through regulating GLUT1 by sponging miR-760. Yes Functionally, the knockdown of circDENND4C suppressed proliferation, migration, and glycolysis of colorectal cancer cells. Similarly, silence of GLUT1 also inhibited cell proliferation, migration, and glycolysis. 32196590 circHUEW1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues interaction[Sponging miR-486] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, we demonstrate that the expression of circHUEW1 is upregulated in CRC tissues. Mechanistically, we demonstrated that circHUWE1 could sponge miR-486 and the downregulation of miR-486 could reverse the cancer suppressive effects caused by silencing circHUWE1. High expression of circHUEW1 was significantly associated with lymphovascular invasion (P =0.036), lymph node metastasis (P =0.017), distant metastasis (P =0.024), and TNM stage (P =0.009). Yes Silencing circHUWE1 significantly inhibited the proliferation, migration and invasion capacity of CRC cells in vitro. 32021287 circPRTM5 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues interaction[miR-377,E2F3 ] qRT-PCR//Luciferase Report Assay//Western Blot The expression of CircPRTM5 in CRC tissues was significantly higher than that in adjacent tissues.CircPRTM5 exerts critical regulatory role in CRC progression by sponging miR-377 to induce E2F3 expression. Yes The results indicate that knockdown of CircPRTM5 can significantly inhibit the proliferation of CRC cells. 32020730 circPTK2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] ISH//qRT-PCR CircPTK2 was elevated in CRC tissues and positively associated with tumor growth and metastasis. CRC patients with increased circPTK2 expression were positively correlated with poorer survival rates. Yes Furthermore, our studies showed that circPTK2 could promote EMT of CRC cells in vitro and in vivo by binding to vimentin protein on sites Ser38, Ser55 and Ser82. 31973707 hsa_circ_0004277 CircRNA Homo sapiens Colorectal Neoplasms tissue samples and cell lines interaction[miR-512-5p,PTMA] qRT-PCR//Microarray High circ-0004277 expression was then verified in tissue samples and cell lines of colorectal cancer via qRT-PCR. In summary, our study showed that circ-0004277 promoted the proliferation of colorectal cancer cells as a miR-512-5p sponge to upregulate the PTMA expression. Kaplan-Meier analysis was used for identifying the association between circ-0004277 expression and the overall survival rate of colorectal cancer patients. Yes From a functional perspective, circ-0004277 knockdown accelerated cell apoptosis and restrained cell proliferation of colorectal cancer. 31960446 hsa_circ_0001178 CircRNA Homo sapiens Colorectal Neoplasms regulation[ZEB1 ] qRT-PCR Mechanistic study revealed that hsa_circ_0001178 acted as a competing endogenous RNA (ceRNA) for miR-382/587/616 to upregulate ZEB1 (a key trigger of epithelial-to-mesenchymal transition), thereby promoting CRC metastatic dissemination. CRC patients with high hsa_circ_0001178 were more prone to have metastatic clinical features, advanced TNM stage and adverse prognosis. Yes Stable knockdown of hsa_circ_0001178 significantly weakened CRC cell migratory and invasive capabilities in vitro as well as lung and liver metastases in vivo. 31747371 hsa_circ_0000218 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[ miR-139-3p/RAB1A axis] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//BrdU//Colony Formation Assay We demonstrated that circ_0000218 was notably upregulated in CRC tissues and cell lines, and its high expression level was markedly linked to the increase of T staging and local lymph node metastasis.Collectively, this study suggested that circ_0000218 upregulated RAB1A and promoted CRC proliferation and metastasis via sponging miR-139-3p. We demonstrated that circ_0000218 was notably upregulated in CRC tissues and cell lines, and its high expression level was markedly linked to the increase of T staging and local lymph node metastasis. Yes Circ_0000218 overexpression enhanced the proliferation and metastasis of CRC cells while knocking down circ_0000218 caused the opposite effects. 31598673 circMET CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-410-3p) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Notably, circMET is substantially upregulated in CRC cell lines and could promote cell proliferation and growth. Yes Notably, circMET overexpression significantly increased cell proliferation and colony formation in SW480 cells  34929287 hsa_circ_0074027 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells  Interaction(microRNA‑525‑3p) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay CircRNA‑0074027 was upregulated in CRC tissues, while miR‑525‑3p expression was reduced. In addition, patients with CRC and circRNA‑0074027 overexpression were more likely to have low tumor differentiation, lymph node metastasis and advanced TMN stage. Yes Deletion of circRNA‑0074027 could suppress cell proliferation and metastasis through up-regulating p53 expression and forbidding epithelial‑mesenchymal transition signaling pathway.  33760126 circEGFR CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction( miR-106a-5p/DDX5 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Here, we confirmed that the level of circEGFR was significantly increased in CRC tissues compared to matched adjacent non-tumor tissues, and a high level of circEGFR was correlated with poor clinicopathological characteristics and poor prognosis in patients with CRC. a high level of circEGFR was correlated with poor clinicopathological characteristics and poor prognosis in patients with CRC Yes Moreover, increased circEGFR expression promoted CRC cell proliferation, migration, and invasion in vitro. Mechanistically, circEGFR acted as a ceRNA for miR-106a-5p to relieve the repressive effect of miR-106a-5p on DDX5 mRNA. Moreover, circEGFR enhanced DDX5 expression, thereby upregulating p-AKT levels. 34320120 hsa_circ_0084615 CircRNA Homo sapiens Colorectal Neoplasms  CRC tissues and cell lines  Interaction(miR-599) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Circ_0084615 was up-regulated in CRC and was correlated with poor overall survival rate and advanced clinical stage of CRC patients. Circ_0084615 was up-regulated in CRC and was correlated with poor overall survival rate and advanced clinical stage of CRC patients. Yes Functional assays validated that depletion of circ_0084615 impeded CRC cell proliferation, migration and invasion. Circ_0084615 acted as a molecular sponge for miR-599 to repress its expression. DNMT3A was a downstream target of miR-599.  34091391 hsa_circ_100146 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(MicroRNA 149/HMGA2 Axis ) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay circRNA 100146 was upregulated in CRC tissues and cells. Yes circRNA 100146 knockdown inhibited cell proliferation, promoted apoptosis, and suppressed migration and invasion in vitro and impeded tumor growth in vivo Also, miR-149 was negatively regulated by circRNA 100146 and was targeted to HMGA2 and mediated its expression. 33257506 hsa_circ_0000467 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Interaction(miR-382-5p/EN2 axis) RNA Pull-Down//Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay In this study, circRNA microarray analysis was utilized to screen differentially expressed circRNA in colorectal cancer (CRC) and circ_0000467 was identified as one circRNA whose expression was significantly upregulated in CRC. Yes The depletion of circ_0000467 expression was found to impede the multiplication, migration, invasion, and epithelial-mesenchymal transition (EMT) processes in CRC cells 33685351 hsa_circ_0005615 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[upregulating TNKS,Wnt/β-catenin pathway] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP Herein, we explored the expression profiles of circRNAs in 5 paired samples of CRC patients by microarray and noted a circRNA, hsa_circ_0005615 (circ5615), was significantly upregulated in CRC tissues. Our results indicated that circ5615 exerted oncogenic function as competing endogenous RNA (ceRNA) of miR-149-5p to release TNKS and activated Wnt/β-catenin pathway. Yes Studies in vitro and in vivo demonstrated that knockdown of circ5615 in cancer cells inhibited proliferation and cell cycle acceleration, while overexpression promoted malignant phenotypes. 32393760 hsa_circ_0007142 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells interaction[CDC25A,miR-122-5p] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The levels of circ_0007142 and CDC25A were enhanced and the level of miR-122-5p was declined in CRC tissues and cells, while the level of DOCK1 had no fluctuation.Circ_0007142 modulated CDC25A expression to promote CRC progression by sponging miR-122-5p. Yes Circ_0007142 knockdown impeded cell proliferation, colony formation, migration, and invasion in CRC cells by regulating miR-122-5p. 32431519 hsa_circ_0003266 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-503-5p/PDCD4 ) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Circ_0003266 was significantly lowly expressed in CRC tissues and cell lines. PDCD4 was a direct target of miR-503-5p and circ_0003266 promoted PDCD4 expression by competitively sponging miR-503-5p. Yes Circ_0003266 overexpression markedly repressed CRC cell proliferation, migration, and invasion, and accelerated the cell apoptosis, but its overexpression promoted the malignant phenotypes of CRC cells. 33726686 hsa_circ_0001946 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[ miR-135a-5p/EMT axis] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Our data showed that the expression of circ_0001946 was upregulated in CRC tissues, which was negatively correlated with tumor size, histologic grade, lymphatic metastasis, and TMN stage, and patients with circ_0001946 overexpression were more likely to have a poor prognosis. To summarize, this study revealed that circRNA_0001946 might act as a tumor promoter by activating the miR-135a-5p/EMT axis and may be a promising treatment target for CRC. Our data showed that the expression of circ_0001946 was upregulated in CRC tissues, which was negatively correlated with tumor size, histologic grade, lymphatic metastasis, and TMN stage, and patients with circ_0001946 overexpression were more likely to have a poor prognosis. Yes In addition, in vitro experiments showed that silencing circ_0001946 inhibited the epithelial-mesenchymal transition (EMT) pathway and markedly suppressed CRC cell growth, migration, and invasion. 32508871 hsa_circ_0026416 CircRNA Homo sapiens Colorectal Neoplasms CRC patient tissues regulation[miR-346/NFIB axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Hsa_circ_0026416 was markedly upregulated in CRC patient tissues and plasma and was a poor prognosis in CRC patients. Hsa_circ_0026416 promotes the progression of CRC via the miR-346/NFIB axis and may represent a potential biomarker for diagnosis and therapy in CRC. Hsa_circ_0026416 was markedly upregulated in CRC patient tissues and plasma and was a poor prognosis in CRC patients. Yes Functionally, hsa_circ_0026416 promotes cell proliferation, migration and invasion both in vitro and in vivo. 33061846 hsa_circ_0000231 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[miR-502-5p/MYO6 axis] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Colony Formation Assay//Transwell Assay Hsa_circ_0000231 expression was dramatically upregulated while miR-502-5p was obviously downregulated in CRC tissues and cells compared with control groups.Hsa_circ_0000231 knockdown inhibited CRC progression and glycolysis by downregulating MYO6 expression through sponging miR-502-5p, which might provide a theoretical basis in further studying circ_0000231-directed therapy in CRC. Yes Functionally, hsa_circ_0000231 knockdown repressed cell glycolysis, proliferation, migration and invasion, and induced cell apoptosis, whereas these effects were decreased by miR-502-5p inhibitor. 32993655 circRAE1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[miR-338-3p/TYRO3 axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We uncovered a novel circRNA Hsa_circ_0060967 (also known as circRAE1) that was remarkably increased in CRC tissues. We identified the network of circRAE1, miR-338-3p, and TYRO3 in CRC cells and determined that the increase in circRAE1 could serve as an oncogene by sponging miR-338-3p, which resulted in an upregulated TYRO3 expression. The high circRAE1 level was positively associated with advanced tumor stage, lymph node metastasis, and tumor size. Yes The loss-of-function assay showed that circRAE1 accelerated cell proliferation, migration, and invasion. 32908453 circNOX4 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[microRNA-485-5p/CKS1B axis] qRT-PCR//Luciferase Report Assay//RIP//Transwell Assay The results demonstrated that the expression of circNOX4 was upregulated in CRC tissues and cell lines compared with that in adjacent normal tissues and a normal colon epithelial cell line, respectively. Collectively, the results of the present study demonstrated that circNOX4 may serve an oncogenic role in CRC by promoting the proliferation, migration, invasion and glycolysis of CRC cells via the miR‑485‑5p/CKS1B axis. Yes CircNOX4 silencing suppressed the proliferation, migration, invasion and glycolysis of CRC cells. 32901890 circFNDC3B CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[circFNDC3B-miR-97-5p-TIMP3 pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//ELISA//Colony Formation Assay//Invasion Assay Expression of circFNDC3B and TIMP3 levels in CRC tissues and cell lines were found to be low, whereas microRNA (miR)-937-5p expression was high in CRC. In conclusion, our work reports a tumor-suppressing role for the circFNDC3B-miR-97-5p-TIMP3 pathway and suggests that circFNDC3B-enriched exosomes can inhibit angiogenesis and CRC progression. Yes In vivo CRC tumor growth, angiogenesis and liver metastasis were suppressed by circFNDC3B overexpression, circFNDC3B-enriched exosomes or miR-937-5p knockdown. 32896063 hsa_circ_0044556 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] CCK8//qRT-PCR//Wound Healing Assay//Microarray Hsa_circ_0044556 was highly expressed in CRC patients and was positively correlated with tumor stage and lymph node metastasis. Hsa_circ_0044556 was highly expressed in CRC patients and was positively correlated with tumor stage and lymph node metastasis. Yes In CRC cell lines, the proliferation, migration, and invasion of cancer cells were inhibited by knocking down hsa_circ_0044556 expression. 32884449 circcse1l CircRNA Homo sapiens Colorectal Neoplasms CRC cell lines and tissue and serum interaction[Binding to eIF4A3] Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay qRT-PCR assays showed that the levels of expression of circ_cse1l were lower in CRC cell lines and in tissue and serum samples from patients with CRC than in control samples. The expression of circ_cse1l is downregulated in CRC. Furthermore, circ_cse1l downregulated PCNA expression by binding to eIF4A3, inhibiting the proliferation of CRC cells. The expression of circ_cse11 in CRC tissues had clinical significance, as its level of expression was inversely associated with the depth of tumor invasion. Yes Overexpression of circ_cse1l in HT29 and HCT116 cells markedly reduced cell proliferation and metastasis. 32857753 circMAT2B CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell regulation[miR-610/E2F1 axis] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay In our study, circMAT2B was found to be upregulated in CRC tissues and cell lines. Moreover, circMAT2B promoted CRC proliferation by regulating the miR-610/E2F1 axis, which may serve as a potential therapeutic target for CRC treatment. Yes Furthermore, the silencing of circMAT2B significantly inhibited proliferation. 32848465 hsa_circ_0136666 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[miR-383/CREB1 Axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay circ_0136666 was aberrantly up-regulated in CRC tissues and cells, circ_0136666 deteriorated CRC through miR-383/CREB1 axis. circ_0136666/miR-383/CREB1 axis might be an underlying therapeutic target for CRC therapy. Yes circ_0136666 was aberrantly up-regulated in CRC tissues and cells, and it promoted the proliferation and glycolysis and inhibited the apoptosis of CRC cells. circ_0136666 accelerated the progression of CRC through directly targeting and down-regulating miR-383. 32821160 circTADA2A CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-374a-3p/KLF14 axis] Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay CircTADA2A was abnormally down-regulated in CRC tissues and cell lines. CircTADA2A functioned as a tumor suppressor in CRC to inhibit the glycolysis and cell cycle and potentiate the apoptosis of CRC cells via miR-374a-3p/KLF14 axis. Yes CircTADA2A overexpression impeded CRC tumor growth in vivo. 32799891 circMBOAT2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and serum interaction[sponging miR-519d-3p] RNA Pull-Down//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay CircMBOAT2 is highly expressed in both CRC tissues and serum samples, and has a correlation with tumor stage. Also, circMBOAT2 regulated cell proliferation and migration by competitively binding to miR-519d-3p and targeting troponin-associated protein (TROAP) in CRC cells. CircMBOAT2 is highly expressed in both CRC tissues and serum samples, and has a correlation with tumor stage. Yes Further functional studies revealed that circMBOAT2 served as a microRNA (miRNA) sponge of miR-519d-3p and promoted the proliferation, migration, and invasion of CRC cells. 32796815 circUBAP2 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cells regulation[miR-199a/VEGFA pathway] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of circUBAP2 was upregulated in CRC tissues and cell lines, and depletion of circUBAP2 suppressed the cell proliferation, migration, and invasion of CRC. Our findings demonstrated that circUBAP2 facilitated CRC progression by sponging miR-199a to upregulate VEGFA. Yes The expression of circUBAP2 was upregulated in CRC tissues and cell lines, and depletion of circUBAP2 suppressed the cell proliferation, migration, and invasion of CRC. 32767322 hsa_circ_102209 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[hsa_circRNA_102209/miR-761/RIN1 signaling] CCK8//qRT-PCR//Flow Cytometry Our results revealed that expression of hsa_circRNA_102209 was remarkably increased in CRC tissues, where the levels of miR-761 were notably reduced (P < .05).More importantly, hsa_circRNA_102209/miR-761/RIN1 signaling may be a novel therapeutic target for the treatment of CRC patients. Yes Knockdown of hsa_circRNA_102209 notably inhibited the proliferation, migration, invasion, and EMT of CRC cells (P < .05), whereas cell cycle arrest at G0/G1 phase and apoptosis were enhanced (P < .05). 32706154 circCTNNA1 CircRNA Homo sapiens Colorectal Neoplasms CC tissues regulation[circCTNNA1/miR-149-5p/FOXM1 axis] Flow Cytometry//qRT-PCR//Wound Healing Assay//Transwell Assay A novel circRNA, circCTNNA1, was significantly upregulated in CC, and its level was associated with advanced tumor-node-metastasis stage and poor prognosis of patients with CC.In summary, our study demonstrated that circCTNNA1 facilitated CC proliferation and invasion via the circCTNNA1/miR-149-5p/FOXM1 axis, and it might function as a novel diagnostic or therapeutic target for patients with CC. Yes The results revealed that circCTNNA1 promoted CC cell proliferation, migration, and invasion in vitro and in vivo. 32699205 circAGFG1 CircRNA Homo sapiens Colorectal Neoplasms cell lines regulation[YY1/CTNNB1] qRT-PCR In this study, circAGFG1 was upregulated in CRC cell lines. In brief, our findings uncovered that circAGFG1 modulated YY1/CTNNB1 axis to drive metastasis and stemness in CRC by sponging miR-4262 and miR-185-5p. Yes CircAGFG1 silencing significantly suppressed cell proliferation, migration, invasion, and stemness, while promoted cell apoptosis in CRC. Meanwhile, we found that circAGFG1 also accelerated CRC tumor growth and metastasis in vivo. 32681092 hsa_circ_0001806 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[COL1A1] CCK8//qRT-PCR//RNA Pull-Down//Luciferase Report Assay Hsa_circ_0001806 was significantly upregulated in CRC tissues and correlated with TNM stage, depth of invasion, lymphatic metastasis and distant metastasis. CircRNA hsa_circ_0001806 may act as a promising therapeutic target by facilitating the stemness of CRC cells via activating the hsa_circ_0001806/miR-193a-5p/COL1A1 axis. Hsa_circ_0001806 was significantly upregulated in CRC tissues and correlated with TNM stage, depth of invasion, lymphatic metastasis and distant metastasis. Yes Hsa_circ_0001806 promoted the stemness of CRC cells, as evident by increasing sphere-formation ability, ALDH1 activity and stemness marker expression while had no effect on cell viability. 32636650 circSAMRCC1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and four cell lines regulation[circSMARCC1/miR-140-3p/MMPs axis] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of circSAMRCC1 in the CRC tissues and four cell lines is significantly increased, and circSMARCC1 and miR-140-3p are negatively correlated with expression level in the tissue. circSMARCC1 competitively combined with miR-140-3p and functioned through a circSMARCC1/miR-140-3p/MMPs axis as a CRC carcinogen, demonstrating its potential as a biomarker for CRC treatment. Yes The downregulation of circSMARCC1 decreased CRC cell viability and suppressed metastasis in vitro and Inhibition of protein (MMP-2, MMP-9, VEGF) expression. 32606978 circNOL10 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells interaction[sponging miR-135a-5p and miR-135b-5p] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay CircNOL10 was decreased in CRC tissues and cells and was associated with poor outcomes. In summary, our results showed that circNOL10 impeded CRC development by mediating proliferation, cell cycle, migration, and invasion by sponging miR-135a-5p and miR-135b-5p, which provided new understanding for CRC treatment. Yes Gain-of-functional experiment revealed that overexpression of circNOL10 constrained proliferation, cell-cycle progression, migration, and invasion of CRC cells, which was abolished by overexpression of miR-135a-5p or miR-135b-5p. 32606737 hsa_circ_0038646 CircRNA Homo sapiens Colorectal Neoplasms CRC cells and tissues regulation[miR-331-3p/GRIK3] qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay Hsa_circ_0038646 was overexpressed in both CRC cells and tissues, and this aberrant expression was positively related with increasing tumor grade.The hsa_circ_0038646/miR-331-3p/GRIK3 axis may be a novel therapeutic and diagnostic target of CRC. Yes Knockdown of hsa_circ_0038646 significantly weakened human CRC cell proliferation and migration. 32565953 hsa_circ_002144 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-615-5p) Western Blot//Wound Healing Assay//CCK8//FISH//Flow Cytometry//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay Firstly, hsa_circRNA_002144 showed significantly elevation in both of CRC tissues and cell lines, and suggested closely associated with poor prognosis in patients. Firstly, hsa_circRNA_002144 showed significantly elevation in both of CRC tissues and cell lines, and suggested closely associated with poor prognosis in patients. Yes Secondly, data from functional assays revealed that silence of hsa_circRNA_002144 inhibited CRC progression with reduced cell viability, proliferation, migration and invasion, while enhanced cell apoptosis. In addition, in vivo CRC growth and metastasis were also suppressed by knockdown of hsa_circRNA_002144. However, CRC progression was promoted with over-expression of hsa_circRNA_002144. Thirdly, hsa_circRNA_002144 colocalized with miR-615-5p in the cytoplasm of CRC cells, and decreased miR-615-5p expression. 33347535 hsa_circ_0031787 CircRNA Homo sapiens Colorectal Neoplasms GEO(CRC) Expression [highly expressed] CCK8//RIP//Flow Cytometry//Luciferase Report Assay//Microarray//IF Hsa_circ_0031787 expression levels in CRC were significantly increased and correlated with advanced TNM stage and lymph node metastasis in CRC patients. Hsa_circ_0031787 expression levels in CRC were significantly increased and correlated with advanced TNM stage and lymph node metastasis in CRC patients. Yes Functional assays showed that hsa_circ_0031787 suppression reduced CRC cell proliferation and invasion in vitro and reduced tumor growth in vivo. 34089272 circCDYL2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(Ezrin) Wound Healing Assay//Migration Assay//qRT-PCR//RNA-seq//Transwell Assay Among the candidate circRNAs, circCDYL2 was the highest overexpressed circRNA in H-RKO compared to parental N-RKO cells. Furthermore, circCDYL2 expression was elevated in CRC tissues and cell lines. circCDYL2 was located in the cytoplasm of CRC cells and interacted with Ezrin to upregulate its protein levels, resulting in AKT phosphorylation. Yes Gain- and loss-of-function assays indicated that circCDYL2 enhanced the migration of CRC cells. 34485151 circEPB41L2 CircRNA Homo sapiens Colorectal Neoplasms exosomes from colorectal cancer patients and cells Interaction(miR-21-5p or miR-942-5p) In Vivo Experiment//qRT-PCR//Luciferase Report Assay//RIP CircEPB41L2 was downregulated in the exosomes from colorectal cancer patients and cells. CircEPB41L2 could sponge miR-21-5p or miR-942-5p. Yes Overexpressed circEPB41L2 inhibited colorectal cancer cell proliferation, migration, invasion and promoted apoptosis, as well as suppressed the activity of PTEN/AKT signalling pathway. 34022068 circCSPP1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-431/LASP1 axis) qRT-PCR//Tunel//Western Blot Our data showed that circ-CSPP1 was significantly overexpressed in CRC tissues and cells. circ-CSPP1 directly targeted miR-431, and circ-CSPP1 knockdown modulated CRC cell progression in vitro via upregulating miR-431. Moreover, LIM and SH3 protein 1 (LASP1) was a functional target of miR-431 in modulating CRC cell malignant progression. Yes The knockdown of circ-CSPP1 attenuated cell proliferation, migration, invasion and promoted apoptosis in vitro and weakened tumor growth in vivo. 34124372 circMAPK14 CircRNA Homo sapiens Colorectal Neoplasms cells and tissue samples Interaction(MKK6/FOXC1) RNA Pull-Down//Western Blot//Co-IP//qRT-PCR//FISH//Transwell Assay We identified that hsa_circ_0131663 (termed circMAPK14) showed significantly decreased expression level in cells and tissue samples of CRC, and was primarily localised in the cytoplasm. We also found that circMAPK14-175aa reduced nuclear translocation of MAPK14 by competitively binding to MKK6, thus facilitating ubiquitin-mediated degradation of FOXC1. Moreover, we described a positive feedback loop in CRC in which elevated FOXC1 expression was caused by reduced circMAPK14-175aa expression. Yes A series of function experiments demonstrated that circMAPK14 influenced CRC progression and metastasis by encoding a peptide of 175 amino acids (termed circMAPK14-175aa). 34709743 hsa_circ_0084927 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-20b-3p/GSTM5/ AKT/mTOR pathway.) qRT-PCR//Wound Healing Assay//Western Blot The expression of circ_0084927 was significantly increased in CRC tissues and cells, and it was higher in advanced-stage CRC compared with early-stage CRC. The expression of circ_0084927 is significantly increased in CRC and higher in advanced-stage CRC than in early-stage CRC. Moreover, circ_0084927 potentially regulates CRC cell migration and invasion via the miR-20b-3p/GSTM5/ AKT/mTOR pathway. The expression of circ_0084927 was significantly increased in CRC tissues and cells, and it was higher in advanced-stage CRC compared with early-stage CRC. Yes Knockdown of circ_0084927 inhibited the migration and invasion of HCT116 cells. Moreover, circ_0084927 was found to act as a sponge of miR-20b-3p. MiR-20b-3p activation reduced the circ_0084927 level, whereas miR-20b-3p inhibition increased the circ_0084927 level. 34629820 circUBAP2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-582-5p/FOXO1 signaling) RNA Pull-Down//Western Blot//qRT-PCR//FISH//IF We find that circUBAP2 is upregulated in CRC tissues and cell lines to induce autophagy both in vitro and in vivo. Mechanistically, we uncover that circUBAP2 can directly interact with miR-582-5p and subsequently act as a microRNA sponge to regulate the expression of the miR-582-5p target gene forkhead box protein O1 (FOXO1) and downstream signaling molecules, which collectively advance the progression and metastasis of CRC. Yes We find that circUBAP2 is upregulated in CRC tissues and cell lines to induce autophagy both in vitro and in vivo. The effects of circUBAP2 on migration, invasion, and proliferation may be partially related to autophagy. 34416339 hsa_circ_0043278 CircRNA Homo sapiens Colorectal Neoplasms tumor samples Expression(lower expressed) CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We discovered that circular RNA hsa_circ_0043278 was significantly downregulated in tumor samples (P < 0.0001) as well as cell lines (P < 0.05). Yes Moreover, we found that overexpression of hsa_circ_0043278 suppressed proliferation and migratory abilities while promoting apoptosis in colorectal cancer cells. 33568942 hsa_circ_0007142 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-455-5p/SGK1 axis) qRT-PCR//Luciferase Report Assay//Western Blot//Transwell Assay Circ_0007142 and SGK1 levels were clearly increased, while miR-455-5p level was reduced in CRC tissues and cell lines. Circ_0007142 could sponge miR-455-5p to regulate SGK1 expression. Moreover, the effects of miR-455-5p on cell proliferation, apoptosis, migration and invasion could be partially reversed by SGK1 overexpression. Besides, circ_0007142 knockdown also suppressed the progression of CRC in vivo. Yes Circ_0007142 silencing promoted cell apoptosis and inhibited cell proliferation, migration and invasion, while these effects of circ_0007142 were partially abolished by miR-455-5p inhibitor in CRC cells. 32889894 circSMAD2 CircRNA Homo sapiens Colorectal Neoplasms CRC cell lines and tissues. Interaction(miR-1258/RPN2 signaling pathway) CCK8//qRT-PCR//Colony Formation Assay//Flow Cytometry Hsa_circ_0000847 (circ_SMAD2) is a novel circRNA that was found to be elevated in CRC cell lines and tissues. Mechanistically, circ_SMAD2 elevated Ribophorin II (RPN2) levels by inhibiting miR-1258. High circ_SMAD2 levels were positively correlated with CRC clinicopathological features. Yes Functional assays revealed that circ_SMAD2 enhanced CRC cell invasion, proliferation, and tumor growth. 33613755 circFAT1 CircRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues and CRC cell lines Interaction(miR-30e-5p/ITGA6 Axis) qRT-PCR//Luciferase Report Assay//Transwell Assay qRT-PCR revealed that circFAT1(e2) in CRC tumor tissues was upregulated compared with that in adjacent normal tissues and was also upregulated in CRC cell lines. We demonstrated that circFAT1(e2) could sponge miR-30e-5p, which regulated the expression level of integrin α6 (ITGA6), the downstream target gene of miR-30e-5p. Rescue assays demonstrated that knockdown of miR-30e-5p enhanced CRC proliferation and migration via ITGA6. Yes The results showed that circFAT1(e2) silencing markedly suppressed CRC growth. Moreover, we identified circFAT1(e2) as a promoter of CRC metastasis. Knockdown of circFAT1(e2) evidently reduced HCT116 and RKO cell migration and invasion. 34257702 hsa_circ_0006174 CircRNA Homo sapiens Colorectal Neoplasms cancer tissues and cell lines Interaction(microRNA-142-3p) qRT-PCR//Western Blot Circ_0006174 was up-regulated in colorectal cancer tissues as well as in cell lines, and its high expression was remarkably associated with enlarged tumour volume and advanced tumour, node, metastasis stage of the patients. Circ_0006174 directly targeted and negatively regulated microRNA-142-3p expression, and X-linked inhibitor of apoptosis, a target gene of microRNA-142-3p, could be indirectly and positively modulated by circ_0006174. Circ_0006174 was up-regulated in colorectal cancer tissues as well as in cell lines, and its high expression was remarkably associated with enlarged tumour volume and advanced tumour, node, metastasis stage of the patients. Yes Circ_0006174 overexpression enhanced colorectal cancer cell proliferation, migration and invasion, and inhibited colorectal cancer cell apoptosis; while knocking down circ_0006174 caused the opposite effects. 34410163 hsa_circ_0089153 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-198/SUMO-specific peptidase 1 (SENP1) axis) qRT-PCR//Luciferase Report Assay//RIP//Western Blot Our data showed that circ_0089153 was overexpressed in CRC tissues and cells. Mechanistically, circ_0089153 targeted miR-198, and the effects of circ_0089153 were mediated by miR-198. SENP1 was identified as a direct and functional target of miR-198. Circ_0089153 worked as a competing endogenous RNA (ceRNA) to post-transcriptionally regulate SENP1 expression by miR-198. Yes . Depletion of circ_0089153 repressed cell proliferation, sphere formation ability, and enhanced cell apoptosis, as well as inhibited tube formation in vitro. Moreover, circ_0089153 depletion diminished tumor growth in vivo. 34516314 hsa_circ_002178 CircRNA Homo sapiens Colorectal Neoplasms CRC cells and tissues Interaction(miR-542-3p/CREB1) CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay The circ_002178 and CREB1 expressions were up-regulated in the CRC cells and tissues, and the miR-542-3p expression was down-regulated (all P<0.05). Our molecular mechanism study revealed that circ_002178, as the molecular sponge of miR-542-3p, promotes CREB1 expression. The downregulation of miR-542-3p or the overexpression of CREB1 is able to partly weaken the inhibition of CRC cells through the circ_002178 knockdown. Yes The circ_002178 knockdown inhibited the proliferation, invasion, colony formation, and glycolysis of the CRC cells in vitro, but the overexpression of circ_002178 induced the opposite result (both P<0.05). 34650680 hsa_circ_0136666 CircRNA Homo sapiens Colorectal Neoplasms cell lines Interaction(miR-497/PD-L1 pathway) Flow Cytometry//qRT-PCR//ELISA//IHC The results showed that hsa_circ_0136666 and PD-L1 was increased in colorectal cancer cells while miR-497 was decreased in colorectal cancer cells when compared with normal colon epithelial cell line. Hsa_circ_0136666 was demonstrated to directly target miR-497, which also regulated PD-L1 by binding to its 3'UTR. Further mechanistic studies identified that hsa_circ_0136666 controlled cell proliferation and apoptosis via targeting miR-497 and regulating PD-L1 expression. Yes Of note, hsa_circ_0136666 stimulated Treg cells mediated by miR-497/PD-L1 axis and its downstream signal pathway in Treg cells. Finally, hsa_circ_0136666 was found to accelerate the tumor growth in vivo. 34320370 circRHOBTB3 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation(FUS and ADARB2) Western Blot//qRT-PCR//RIP//IP//Transwell Assay We identified circRHOBTB3 which is markedly downregulated in CRC tissues and cell lines. Mechanistically, circRHOBTB3 binds to HuR, which is a ubiquitously expressed and functional RNA-binding protein (RBP) in CRC development, and promotes β-Trcp1-mediated ubiquitination of HuR. Normally, HuR binds to the 3'UTR of target mRNAs to facilitate their stabilization, whereas the interaction between circRHOBTB3 and HuR degrades HuR to reduce the expression level of the downstream target PTBP1. Furthermore, lower circRHOBTB3 levels were significantly associated with advanced clinical stages and greater risk of metastases. Yes Overexpression of circRHOBTB3 suppresses tumor metastasis in CRC cells. 34158864 hsa_circ_0000372 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-495/IL6 axis) qRT-PCR//Luciferase Report Assay//Western Blot Circ_0000372 was markedly upregulated in CRC, and its high expression was associated with the poor prognosis of CRC patients. Bioinformatics prediction and experimental verification proposed that circ_0000372 could sponge miR-495, and miR-495 could target IL6. Besides, the JAK2/STAT3 signaling pathway activation could be regulated by circ_0000372, miR-495 and IL6. Circ_0000372 was markedly upregulated in CRC, and its high expression was associated with the poor prognosis of CRC patients. Yes Silenced circ_0000372 was able to suppress CRC cell proliferation, migration and invasion in vitro and CRC tumor growth in vivo. 33534412 hsa_circ_0026628 CircRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(miR-346/SP1/ Wnt/β-catenin pathway) RNA Pull-Down//ChIP//Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//IF We identified that hsa_circ_0026628 (circ_0026628), a circular RNA that originated from SP1 pre-mRNA, was upregulated in CRC cells.Mechanistically, circ_0026628 served as the endogenous sponge of miR-346 and FUS to elevate SP1 expression at the post-transcriptional level, thus strengthening the interaction between SP1 and β-catenin to activate the Wnt/β-catenin pathway. Yes The results depicted that circ_0026628 functioned as a contributor to CRC cell proliferation, migration, EMT, and stemness. 34420031 circCTNNA1 LncRNA Homo sapiens Colorectal Neoplasms miR-363-3p/CXCL5 axis Interaction(miR-363-3p) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircCTNNA1 and CXCL5 were highly expressed in CRC. Moreover, miR-363-3p could interact with CXCL5, and CXCL5 overexpression also could reverse the suppressive effect of miR-363-3p on CRC progression. Yes Knockdown of circCTNNA1 could inhibit the proliferation, cell cycle, metastasis, and promote the apoptosis of CRC cells. MiR-363-3p could be sponged by circCTNNA1, and the inhibition effect of circCTNNA1 silencing on CRC progression could be reversed by miR-363-3p inhibitor. Downregulation of circCTNNA1 also could hinder the tumor growth of CRC in vivo. 33640021 circNRIP1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR‑532‑3p) qRT-PCR//Luciferase Report Assay The results of the present study indicated that circNRIP1 was upregulated in CRC and its increased expression was associated with CRC progression. Bioinformatics analysis predicted that miR‑532‑3p was a direct target of circNRIP1, which was further confirmed by a dual‑luciferase reporter assay. miR‑532‑3p silencing reversed the effects of circNRIP1 knockdown on the sensitivity of 5‑FU in the chemotherapy of CRC. Yes Furthermore, overexpression of circNRIP1 promoted CRC cell proliferation, invasion and migration, while it inhibited apoptosis. Knockdown of circNRIP1 significantly enhanced the 5?FU?induced inhibition of the viability of HCT116 and SW480 cells. 34396434 hsa_circ_0084615 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-599/ONECUT2 axis) RNA Pull-Down//Western Blot//qRT-PCR//RIP//IHC Circ_0084615 was elevated in CRC tissues and was linked to TNM stages, lymph node metastasis, differentiation and overall survival rate. Circ_0084615 sponged miR-599 and miR-599 inhibition reversed circ_0084615 knockdown-mediated effects on CRC cell growth, motility and angiogenesis. ONECUT2 was identified as the target gene of miR-599. Yes Circ_0084615 knockdown inhibited CRC cell proliferation, migration, invasion and angiogenesis in vitro and hampered tumorigenesis in vivo. 34253241 circGALNT16 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Regulation(SENP2-mediated hnRNPK-p53) CCK8//qRT-PCR Circ-GALNT16 was downregulated in CRC and was negatively correlated with poor prognosis.Mechanistically, circ-GALNT16 could bind to the KH3 domain of heterogeneous nuclear ribonucleoprotein K (hnRNPK), which promoted the SUMOylation of hnRNPK. Yes Circ-GALNT16 suppressed the proliferation and metastatic ability of CRC cells in vitro and in vivo. 34452628 hsa_circ_0040809 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-515-5p/DNMT1 axis) CCK8//qRT-PCR//Western Blot In CRC tissues and cells, circ_0040809 and DNMT1 expression are markedly increased, whereas miR-515-5p expression is decreased. Mechanistically, circ_0040809 competitively binds to miR-515-5p to elevate DNMT1 expression. Rescue assay reveals that overexpressed miR-515-5p partly counteracts the tumor-facilitating impact of circ_0040809. Also, high circ_0040809 expression is significantly linked to shorter overall survival. Yes Cell function compensation experiments reveal that circ_0040809 silencing inhibits CRC cell proliferation and migration and promotes apoptosis, while circ_0040809 overexpression has the opposite effects. 34438465 hsa_circ_0007919 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-942-5p/TET1 axis) CCK8//qRT-PCR//Western Blot It was revealed that, in CRC tissues and cell lines, circ_0007919 and TET1 expressions were reduced whereas miR-942-5p expression was enhanced. In addition, circ_0007919 could competitively bind with miR-942-5p to increase the expression of miR-942-5p's target gene TET1. Yes It was also revealed that circ_0007919 overexpression markedly suppressed CRC cell growth and migration. 34906917 hsa_circ_0044556 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer samples and cells Interaction(miR-665/Diaphanous Homolog 1 axis) CCK8//qRT-PCR//Western Blot Circ_0044556 was upregulated in colorectal cancer samples and cells. Our findings manifested that circ_0044556 functioned as an oncogenic circRNA in colorectal cancer by mediating the miR-665/Diaphanous Homolog 1 axis. Yes Silencing circ_0044556 inhibited cell proliferation, cell cycle progression, migration, invasion, and epithelial-mesenchymal transition in CRC cells. 34822025 circASXL1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-1205) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Invasion Assay//Transwell Assay CircASXL1 and GRIK3 expression were apparently upregulated, and miR-1205 expression was downregulated in CRC tissues and cells relative to control groups. Additionally, circASXL1 acted as a sponge for miR-1205, and miR-1205 was associated with GRIK3. Yes CircASXL1 knockdown inhibited cell colony-forming ability, migration and invasion, whereas induced cell arrest at G0/G1 phase and cell apoptosis in CRC cells; however, these effects were attenuated by miR-1205 inhibitor.Furthermore, circASXL1 silencing hindered tumor formation by upregulating miR-1205 and downregulating GRIK3 expression. 34127015 hsa_circ_0062682 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-940/PHGDH Axis) CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining y online analyses and experimental validations, we showed that circ_0062682 expression was aberrantly increased in CRC tissues compared with paired normal tissues. Mechanistically, we revealed that circ_0062682 could sponge miR-940 and identified D-3-phosphoglycerate dehydrogenase (PHGDH), a key oxidoreductase involved in serine biosynthesis, as a novel target of miR-940. Increased expression of circ_0062682 in CRC notably correlated with a poor prognosis and advanced tumor stage. Yes Functional experiments showed that circ_0062682 knockdown reduced CRC growth both in vitro and in vivo. 34957102 circRNF121 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-1224-5p/FOXM1 axis) Wound Healing Assay//Migration Assay//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Invasion Assay//Transwell Assay Circ-RNF121 and FOXM1 expression were dramatically upregulated, while miR-1224-5p expression was downregulated in CRC tissues or cells compared with control groups. Additionally, circ-RNF121 acted as a sponge of miR-1224-5p and miR-1224-5p bound to FOXM1. Yes Circ-RNF121 silencing repressed cell proliferation, migration, invasion and glycolysis but induced cell apoptosis in CRC, which were attenuated by miR-1224-5p inhibitor. 34742305 circMFN2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-574-3p/IGF1R Signaling Axis) Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ-MFN2 expression was elevated in CRC tissues and cells.MiR-574-3p could be sponged by circ-MFN2, and its inhibitor reversed the suppression effect of circ-MFN2 silencing on CRC progression. Moreover, IGF1R was a target of miR-574-3p, and its overexpression reversed the inhibition effect of miR-574-3p mimic on CRC progression.  Yes Knockdown of circ-MFN2 restrained the proliferation, migration, invasion, and radioresistance of CRC cells in vitro. Furthermore, silenced circ-MFN2 also reduced the tumor volume and weight of CRC in vivo. 34093664 hsa_circ_0007031 CircRNA Homo sapiens Colorectal Neoplasms CRC specimens (N = 50) and paracancerous normal colorectal tissues (N = 50) Interaction(miR-485-3p/MELK axis) CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining Circ_0007031 and MELK expression were obviously increased, while miR-485-3p expression was decreased in CRC tissues and cells compared with normal colorectal tissues or cells. Circ_0007031 controlled MELK expression via interacting with miR-485-3p. Yes Circ_0007031 knockdown repressed proliferation, whereas induced cell arrest at G0/G1 phase and apoptosis. On the opposite, circ_0007031 overexpression promoted cell proliferation and induced cell arrest at S phase. Furthermore, circ_0007031 contributed to tumor formation in vivo. 34322757 circSIRT1 CircRNA Homo sapiens Colorectal Neoplasms CRC cells and tissue Interaction(eIF4A3) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Colony Formation Assay The RT-qPCR results showed that circ-SIRT1 was highly expressed in CRC cells and tissue and was positively correlated with the depth of tumor invasion. We further found that EIF4A3 could bind to circ-SIRT1, and that overexpressing circ-SIRT1 decreased the abundance of EIF4A3 at the mRNAs of the EMT marker proteins N-cadherin and vimentin. The RT-qPCR results showed that circ-SIRT1 was highly expressed in CRC cells and tissue and was positively correlated with the depth of tumor invasion. Yes Knocking down circ-SIRT1 inhibited the proliferation and invasion of CRC cells and EMT. 34660182 circHERC4 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-556-5p/CTBP2/E-cadherin pathway) CCK8//qRT-PCR//Western Blot We demonstrated that circHERC4 was aberrantly elevated in CRC tissues (P < 0.001), and was positively associated with lymph node metastasis and advanced tumor grade (P < 0.01). Mechanistically, we revealed that circHERC4 inactivated the tumor suppressor, miR-556-5p, leading to the activation of CTBP2/E-cadherin pathway which promotes tumor metastasis in CRC. Notably, the expression of circHERC4 was associated with worse survival in patients with CRC. Yes Silencing of circHERC4 significantly inhibited the proliferation and migration of two highly aggressive CRC cell lines and reduced liver and lung metastasis in vivo. 34781990 hsa_circ_0005927 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues or cells Interaction(miR-942-5p/BATF2 Axis) qRT-PCR//Western Blot Circ_0005927 expression and the mRNA and protein expression of BATF2 were dramatically downregulated, while miR-942-5p expression was obviously upregulated in CRC tissues or cells compared with control groups. Furthermore, circ_0005927 was a sponge of miR-942-5p, and miR-942-5p bound to BATF2. Yes Circ_0005927 overexpression repressed cell colony-forming ability, migration and invasion, whereas induced cell apoptosis in CRC; however, these impacts were hindered by miR-942-5p mimic or BATF2 knockdown. 33732022 hsa_circ_001659 CircRNA Homo sapiens Colorectal Neoplasms CRC cell Regulation qRT-PCR ROC curve analysis demonstrated the predictive values and likelihood ratios of circ_001659 were satisfactory for the diagnosis of CRC, including patients in early-stage disease or patients with carcinoembryonic antigen (CEA)-negative status. Mechanistically, circ_001659 was localized in the nucleus, recruited the RBBP5 to Vimentin promoter and increased H3K4 trimethylation level on the Vimentin promoter region, which epigenetically activated Vimentin transcription. Yes We further investigated the oncogenic role of circ_001659. In vivo and in vitro experiments indicated that circ_001659 could promote CRC cell invasion and migration. 33725570 circRAD23B CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-1205/TRIM44 axis) CCK8//qRT-PCR//Western Blot We identified that circRAD23B was overexpressed in CRC tissues and cells. Target analysis indicated that circRAD23B-targeted miR-1205 and TRIM44 were downstream genes of miR-1205. Moreover, the antitumor response of circRAD23B downregulation and miR-1205 overexpression was, respectively, achieved by increasing miR-1205 and decreasing TRIM44. Yes CRC cell proliferation, cell cycle progression, and cell metastasis were inhibited, while apoptosis was promoted by downregulating circRAD23B. 33634427 circDOCK1 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cells Interaction(miR-132-3p/USP11 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//IP//IHC//Transwell Assay Circ_DOCK1 expression was enhanced in colorectal cancer tissues and cells. Circ_DOCK1 sponged miR-132-3p, and miR-132-3p silence mitigated the effect of circ_DOCK1 interference on cell growth, metastasis, and apoptosis. MiR-132-3p targeted USP11, and circ_DOCK1 could regulate USP11 level by miR-132-3p. Yes Silencing circ_DOCK1 repressed cell growth, migration, and invasion, and facilitated apoptosis. 33685455 circRASSF2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-195-5p/FZD4 axis ) CCK8//qRT-PCR//Western Blot Our study reported that circRASSF2 was upregulated in CRC tissues and cells, and its high expression was related to the poor prognosis of CRC patients. Besides, our data revealed that circRASSF2 could sponge miR-195-5p, and miR-195-5p could target FZD4. The rescue experiments indicated that both miR-195-5p inhibitor and FZD4 overexpression could reverse the negative regulation of circRASSF2 silencing on CRC progression. Moreover, circRASSF2 could positively regulate the activity of Wnt/β-catenin signaling pathway by the miR-195-5p/FZD4 axis. Our study reported that circRASSF2 was upregulated in CRC tissues and cells, and its high expression was related to the poor prognosis of CRC patients. Yes CircRASSF2 knockdown could inhibit proliferation, migration, invasion, and enhance apoptosis in CRC cells, and its overexpression had the opposite effect. 33929991 hsa_circ_0115744 CircRNA Homo sapiens Colorectal Neoplasms patients with CRC with liver metastasis Interaction(miR-144/EZH2 axis) qRT-PCR//Western Blot We detected the upregulated expression of circ_0115744 in patients with CRC with liver metastasis (CRLM). Further investigation using a validation set indicated that circ_0115744 might be considered as a fingerprint for CRLM. Mechanistic analysis showed that circ_0115744 acted as a competing endogenous RNA of miR-144 to diminish the repressive effect of miR-144 on its target EZH2. Yes Functionally, the overexpression of circ_0115744 significantly promoted the invasion of CRC cell lines, while decreased expression of circ_0115744 suppressed cell invasion in vitro. 33591945 circNSUN2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR‑181a‑5p/ROCK2 axis) CCK8//qRT-PCR//Western Blot The results revealed that circNSUN2 was highly expressed in CRC tissues and cell lines. Moreover, miR‑181a‑5p was revealed to be a target gene of circNSUN2, and the expression of ROCK2 was negatively regulated by miR‑181a‑5p. Knockdown of circNSUN2 inhibited proliferation and migration, and induced apoptosis of CRC cells and suppressed tumor growth by targeting miR‑181a‑5p to decrease ROCK2 expression. Yes Knockdown of circNSUN2 inhibited the malignant biological behavior of CRC in vivo and in vitro. 34080658 hsa_circ_1662 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction( YAP1/SMAD3 pathway) RNA Pull-Down//Western Blot//ISH//FISH//RIP//IHC//IF A novel circRNA, circ1662, exhibited significantly higher expression in CRC tissues than paired normal tissues. Mechanistically, circ1662 directly bound to YAP1 and accelerated its nuclear accumulation to regulate the SMAD3 pathway. Additionally, circ1662 enhanced CRC invasion and migration depending on YAP1 and SMAD3. High circ1662 expression was correlated with poor prognosis and tumor depth in patients with CRC. Yes Functionally, circ1662 promoted CRC cell invasion and migration by controlling EMT in vitro and in vivo. 33754062 hsa_circ_0001666 CircRNA Homo sapiens Colorectal Neoplasms CRC cell lines along and tissues Interaction(miR-576-5p/PCDH10 axis) CCK8//qRT-PCR Hsa_circ_0001666 was downregulated in both CRC cell lines along with tumour tissues. Moreover, the mechanistic study showed that hsa_circ_0001666, acting as 'ceRNA' of miR-576-5p, prevented PCDH10 downregulation, as well as suppressed EMT and stemness of CRC cells, and the Wnt/β-catenin signalling pathway. higher expression level of hsa_circ_0001666 indicated a better clinical prognosis in patients with CRC. Yes Hsa_circ_0001666 knockdown significantly supported CRC cell proliferation along with invasion and inhibited cell apoptosis in vitro. Hsa_circ_0001666 knockdown accelerated the CRC growth and metastasis in vivo. 34841662 circSPARC CircRNA Homo sapiens Colorectal Neoplasms the tissues and plasma of CRC patients Regulation（JAK/STAT pathway ） CCK8//qRT-PCR CircSPARC was upregulated in both the tissues and plasma of CRC patients. Mechanistically, circSPARC sponged miR-485-3p to upregulate JAK2 expression and ultimately contribute to the accumulation of phosphorylated (p)-STAT3. Besides, circSPARC recruited FUS, which facilitated the nuclear translocation of p-STAT3. High expression of circSPARC was associated with advanced TNM stage, lymph node metastases, and poor survival. Yes Silencing circSPARC inhibited CRC cell migration and proliferation in vitro and vivo. 34074294 circMYH9 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression [highly expressed] qRT-PCR We identified an intron-derived circRNA, circMYH9, which was significantly upregulated in CRC tissues. Mechanistically, circMYH9 destabilized the pre-mRNA of p53 by recruiting hnRNPA2B1 in the nucleus. hnRNPA2B1 bound to N6-methyladenosine sites on the 3' untranslated region of p53 pre-mRNA and maintained its stability. Moreover, a lack of amino acids led to an elevated level of ROS, resulting in increased HIF1α, which promoted circMYH9 expression by binding to the promoter region. A higher circMYH9 level correlated with shorter relapse-free survival and overall survival of CRC patients. Yes CircMYH9 promoted serine/glycine metabolism, the NAD + /NADH ratio, and glutathione recycling and inhibited reactive oxygen species (ROS) in a p53-dependent manner, impacting tumour growth. Furthermore, in vivo AAV9-mediated transfection of circMYH9 could drive chemically-induced carcinogenesis by suppressing p53 in mice. 34496888 hsa_circ_0001073 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-582-3p/RGMB Axis) CCK8//qRT-PCR//Transwell Assay circ_0001073 was remarkably under-expressed in NSCLC tissues and cells.circ_0001073 directly bound to miR-582-3p and acted as a miRNA sponge to regulate RGMB expression. Besides, miR-582-3p overexpression or knockdown of RGMB remarkably reversed the malignant phenotypes of NSCLC cells induced by the up-regulation of circ_0001073 expression. Yes circ_0001073 overexpression impeded the multiplication, migration, and invasion and enhanced the apoptosis of NSCLC cells in vitro. 34939762 circFARSA CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation( PI3K/AKT signaling pathway) qRT-PCR//Western Blot//Transwell Assay//FISH CircFARSA was significantly upregulated in NSCLC tissues, and the ectopic overexpression of circFARSA enhanced NSCLC cell metastasis. Mechanistically, exosomal circFARSA induced M2 polarization via PTEN ubiquitination and degradation, which further activated the PI3K/AKT signaling pathway. In addition, eIF4A3 promoted circRNA biogenesis and cyclization by binding to its flanking sequences. CircFARSA was significantly upregulated in NSCLC tissues, and the ectopic overexpression of circFARSA enhanced NSCLC cell metastasis. Yes Furthermore, NSCLC cell-derived exosomal circFARSA polarized the macrophages to a M2 phenotype. The NSCLC cells co-cultured with macrophages transfected with circFARSA or pre-treated with exosomal circFARSA showed enhanced EMT and metastasis 34119765 hsa_circ_0103552 CircRNA Homo sapiens Breast Neoplasms BC and nontumor tissues,cell lines(BT‐20, T47D, MFC7, SKBR3 and MDA‐MB‐231, MCF10A) Interaction[miR-1236] qRT-PCR//Luciferase Report Assay//Cell Viability Assay As data indicated, circ_0103552 was significantly elevated in BC tissue samples and cells. In addition, its expression correlates with clinical severity and dismal prognosis. Furthermore, circ_0103552 could facilitate cell growth, clone-forming ability, migration and invasion, and decrease apoptotic cells. For the mechanism exploration, circ_0103552 could directly sponge miR-1236 to execute oncogenic activities in BC cells. In summary, this study provides a novel circRNA in tumorigeneis and progression of BC and may help to develop effective therapeutic target for this devastating disease. Yes " The results revealed that the viability of cells in cell lines MCF7 decreased significantly after silencing of circ_0103552 (Figure 2C and 2D). In MDA‐MB‐231 cells, cell proliferation ability was strikingly elevated in the circ_0103552 overexpression groExpression[Expression[up-expression]-expression] compared to empty vector groExpression[Expression[up-expression]-expression] (Figure 2C and 2D). Afterward, flow cytometric analyses were conducted in two cell lines. As Figure 2E shows, after knockExpression[down-expression] of circ_0103552 in MCF7 cell line, cell apoptotic rate was remarkably boosted. Whereas, cell apoptosis was decreased after circ_0103552 overexpressed. " 31056795 circACAP2 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[miR-29a/b-3p-COL5A1 axis] CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay CircACAP2 expression was prominently elevated in tumorous tissues.Functionally and mechanistically, circACAP2 promoted breast cancer proliferation and motility by sponging miR-29a/b-3p and modulating COL5A1. Yes According to the results, cell proliferation and motility ability decreased and apoptosis ability increased after circACAP2 knockExpression[down-expression]. 31863774 circUBE2D2 CircRNA Homo sapiens Breast Neoplasms BC tissues,cell lines Interaction[Sponging miR-1236 and miR-1287] CCK8//qRT-PCR//Luciferase Report Assay//IHC In the current study, we screened and identified a novel circRNA, circ-UBE2D2, which was highly expressed in BC cell lines and tissues and was closely related to aggressive clinical features and dismal prognosis. Mechanistically, circ-UBE2D2 was able to simultaneously function as molecular sponges of miR-1236 and miR-1287 to regulate the expression of their respective target genes. Yes Small interfering RNA (siRNA)-mediated circ-UBE2D2 silencing notably inhibited the proliferation, migration and invasion of BC cells, whereas circ-UBE2D2 overexpression displayed opposite effects. 31336316 hsa_circ_100876 CircRNA Homo sapiens Breast Neoplasms BC tissue Interaction[adsorbing microRNA-361-3p] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay QRT-PCR results showed that circRNA_100876 level in BC tissues was conspicuously higher than that in the adjacent tissues.QRT-PCR revealed that microRNA-361-3p and circRNA_100876 showed a negative correlation in the expression level of genes in BC tissues. In addition, the results of the Luciferase reporter gene assay confirmed that circRNA_100876 can be targeted by microRNA-361-3p through their binding site. Moreover, patients with a high expression of circRNA_100876 had a relatively lower overall survival rate. Yes Compared with the NC group, the cell proliferation and invasion ability of circRNA_100876 knockdown group was conspicuously decreased. 31486496 hsa_circ_0072309 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[targeting miR-492] qRT-PCR hsa_circ_0072309 expression in breast cancer tissues was upregulated relative to that in adjacent normal tissues.The results of our mechanistic studies indicated that hsa_circ_0072309 could act as the sponge of miR-492, which exhibited increased expression in breast cancer tissues. Hsa_circ_0072309 suppressed breast cancer cell proliferation, migration, and invasion by inhibiting miR-492. Yes hsa_circ_0072309 overexpression dramatically inhibited the proliferation, migration, and invasion of breast cancer cells in vitro. In vivo assays revealed that the ectopic expression of hsa_circ_0072309 repressed breast cancer growth. 30774431 hsa_circ_0006528 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[MAPK/ERK signaling pathway1] qRT-PCR We analyzed a cohort of 97 patients and found that circ_0006528 expression was significantly upregulated in human breast cancer tissues compared with that in adjacent non-tumorous tissues and was significantly associated with advanced tumor-node-metastasis (TNM) stage and poor prognosis.Further mechanistic studies revealed that circ_0006528 could sponge endogenous miR-7-5p and inhibit its activity. We also identified Raf1, which activates the MAPK/ERK signaling pathway, as a target of miR-7-5p and determined that circ_0006528 promotes breast cancer growth, invasion, and migration by promoting the expression of Raf1 and activates the MAPK/ERK pathway. We analyzed a cohort of 97 patients and found that circ_0006528 expression was significantly upregulated in human breast cancer tissues compared with that in adjacent non-tumorous tissues and was significantly associated with advanced tumor-node-metastasis (TNM) stage and poor prognosis. Yes Downregulating circ_0006528 induced G2 phase arrest and cell apoptosis. 31072375 hsa_circ_0004771 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[ ZEB2 signaling pathway] CCK8//qRT-PCR//Flow Cytometry//Western Blot hsa_circ_0004771 and Zinc finger E-box binding homeobox 2 (ZEB2) expression levels were up-regulated and positively correlated in breast cancer tumor tissues. Yes Knockdown of hsa_circ_0004771 and ZEB2 served as equally authentic of miR-653 mimics to induce growth inhibition and apoptosis in breast cancer cells. 30979827 circDENND4C CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[miR-200b/c ] qRT-PCR//Transwell Assay//RIP//Western Blot circDENND4C highly expressed in breast cancer was up-regulated in response to hypoxia.circDENND4C was validated as a sponge of miR-200b and miR-200c. Deficiency of miR-200b or miR-200c reversed the suppressive effect of circDENND4C knockdown on breast cancer progression. Moreover, silence of circDENND4C reduced xenograft tumor growth by increasing miR-200b and miR-200c. Yes Knockdown of circDENND4C decreased glycolysis, migration and invasion in breast cancer cells under hypoxia. 31488193 hsa_circ_001569 CircRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction[PI3K-AKT pathway ] qRT-PCR//Western Blot We found that hsa_circ_001569 expression was significantly up-regulated in both BC tissues and cell lines.Besides, molecular mechanistic study revealed that depression of hsa_circ_001569 impeded the activation of PI3K-AKT signaling in BC cells. Our results indicated that hsa_circ_001569 upregulation was associated with BC lymph-node metastasis, clinical stage, and poor prognosis. Hsa_circ_001569 might contribute to progression of BC by modulating PI3K-AKT pathway. Overexpression of hsa_circ_001569 was associated with Lymph node metastasis, advanced clinical stage and shorter overall survival.Multivariate assay confirmed that hsa_circ_001569 expression was an independent prognostic factor for 5-year overall survival. Yes Furthermore, functional investigations revealed that knockdown of hsa_circ_001569 significantly suppressed the growth and metastatic potentials of BC cells. 31104012 circPLK1 CircRNA Homo sapiens Breast Neoplasms cell lines Interaction[sponging miR-296-5p] qRT-PCR//Microarray CircPLK1 was significantly upregulated in TNBC and associated with poor survivals.CircPLK1-miR-296-5p-PLK1 axis regulates tumor progression by ceRNA mechanism in TNBC, indicating that circPLK1 may serve as a prognostic factor and novel therapeutic target for TNBC. CircPLK1 was significantly upregulated in TNBC and associated with poor survivals. Yes CircPLK1 knockdown inhibited cell growth and invasion in vitro as well as tumor occurrence and metastasis in vivo. 31337246 circTADA2A-E6 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[miR-203a-3p/SOCS3 axis] Western Blot//FISH//qRT-PCR//Luciferase Report Assay//Microarray We detected two circRNAs, circTADA2A-E6 and circTADA2A-E5/E6, which were among the top five differentially expressed circRNAs in breast cancer. They were consistently and significantly decreased in a large cohort of breast cancer patients, and their downregulation was associated with poor patient survival for TNBC.circTADA2A-E6 preferentially acted as a miR-203a-3p sponge to restore the expression of miRNA target gene SOCS3, resulting in a less aggressive oncogenic phenotype. circTADA2As as promising prognostic biomarkers in TNBC patients, and therapeutic targeting of circTADA2As/miRNA/mRNA network may be a potential strategy for the treatment of breast cancer. We detected two circRNAs, circTADA2A-E6 and circTADA2A-E5/E6, which were among the top five differentially expressed circRNAs in breast cancer. They were consistently and significantly decreased in a large cohort of breast cancer patients, and their downregulation was associated with poor patient survival for TNBC. Yes Especially, circTADA2A-E6 suppressed in vitro cell proliferation, migration, invasion, and clonogenicity and possessed tumor-suppressor capability. 30787278 circBMPR2 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[ circBMPR2/miR-553/USP4 Axis] Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Microarray//Colony Formation Assay//Transwell Assay In this study, we identified a novel circRNA (named circBMPR2) whose expression was lower in breast cancer tissues with metastasis. Mechanistically, we demonstrated that circBMPR2 could abundantly sponge miR-553 and that miR-553 overexpression could attenuate the inhibitory effects caused by circBMPR2 overexpression. We also found that ubiquitin-specific protease 4 (USP4) was a direct target of miR-553, which functions as a tumor suppressor in breast cancer. Our findings demonstrated that circBMPR2 might function as a miR-553 sponge and then relieve the suppression of USP4 to inhibit the progression and tamoxifen resistance of breast cancer. Targeting this newly identified circRNA may help us to develop potential novel therapies for breast cancer patients. Yes Functionally, we found that circBMPR2 knockdown effectively enhanced cell proliferation, migration, and invasion. Moreover, circBMPR2 knockdown promoted tamoxifen resistance of breast cancer cells through inhibiting tamoxifen-induced apoptosis, whereas circBMPR2 overexpression led to decreased tamoxifen resistance. 31302495 circKDM4C CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[lower expressed] qRT-PCR//Luciferase Report Assay//RIP Furthermore, we analyzed a cohort of breast cancer patients and found that circKDM4C expression was decreased in breast cancer tissues, and lower circKDM4C expression was associated with poor prognosis and metastasis in breast cancer. Yes Functionally, we demonstrated that circKDM4C significantly repressed breast cancer proliferation, metastasis 31406252 circFBXL5 CircRNA Homo sapiens Breast Neoplasms cell lines Interaction[sponging miR-660] CCK8//RIP//Colony Formation Assay//Microarray We confirmed the expression of circFBXL5 and found that circFBXL5 was upregulated in breast cancer cell lines, especially in MDA‐MB‐453 and MDA‐MB‐231 (Figure ​(Figure1D).1D). Collectively, our study highlighted the regulatory function of the circFBXL5/miR-660/SRSF6 pathway in breast cancer progression, which could be potential therapeutic targets for breast cancer. Yes "To investigate circFBXL5 functions in breast cancer, we knocked down circFBXL5 successful by si‐circFBXL5#1 (Figure ​(Figure2A).2A). CCK‐8 assay revealed that circFBXL5 down‐regulation suppressed cell proliferation (Figure ​(Figure2B).2B). And knockdown of circKIF4A suppressed breast cancer cell colony formation ability (Figure ​(Figure22C). " 31729134 hsa_circ_0136666 CircRNA Homo sapiens Breast Neoplasms cell lines Interaction[miR-1299 and targeting CDK6] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Transwell Assay It was displayed that hsa_circ_0136666 was greatly increased in breast cancer. In conclusion, it was revealed that Upregulation of hsa_circ_0136666 promoted breast cancer progression by sponging miR-1299 and targeting CDK6. Yes Meanwhile, its Upregulation repressed breast cancer proliferation, migration and invasion capacity, which could be reversed by the increase of hsa_circ_0136666. 30993801 hsa_circ_0001283 CircRNA Homo sapiens Breast Neoplasms Breast cancer tissue interaction[MiR-187/HIPK3 Axis] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Downregulation of circRNA-0001283 expression was observed in breast cancer tissue samples.Finally, we showed that circRNA-0001283 positively regulated HIPK3 expression by sponging miR-187. Yes Ectopic expression of circRNA-0001283 remarkably suppressed cell viability and invasion, and induced apoptosis in breast cancer cells. 32066649 circSETD2 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[ miR-155-5p/SCUBE2 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay circ_SETD2 and SCUBE2 were downregulated, while miR-155-5p was upregulated in BC tissues and cells.Therefore, circ_SETD2 curbed BC progression via upregulating SCUBE2 via binding to miR-155-5p. Yes Both circ_SETD2 and SCUBE2 elevation arrested cell cycle progression, inhibited cell proliferation, migration, and invasion, and accelerated cell apoptosis in BC cells. Moreover, circ_SETD2 upregulation repressed BC growth in vivo. 33336052 circNR4A1 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines,peripheral blood Expression[lower expressed] CCK8//qRT-PCR//Western Blot The expression of circNR4A1(Hsa-circ-0026352) was lower in breast cancer tissues, peripheral blood and breast cancer cell lines than in adjacent normal tissues, healthy individuals' peripheral blood and human breast epithelial cells. Yes Over-expression of circNR4A1 in MCF-7 cells inhibited the cell proliferation, promoted cell apoptosis and blocked the cell cycle in G1/S phase. 33325363 hsa_circ_0069094 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[miR-591/HK2 axis] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//Colony Formation Assay In the present study, we verified that circ_0069094 was upregulated in BC tissues and cells.In conclusion, these results indicated that circ_0069094 facilitated cell malignancy and glycolysis by upregulating HK2 through adsorbing miR-591, suggesting that circ_0069094 might be a prognostic biomarker and therapeutic target for BC. Yes Functional analysis revealed that circ_0069094 silencing induced apoptosis, curbed proliferation, and reduced glycolysis in BC cells in vitro, but circ_0069094 overexpression had an opposing influence. Also, circ_0069094 knockdown reduced BC growth in vivo. 33309838 circSLC8A1 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines regulation[PTEN/PI3k/Akt pathway] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay We demonstrated that circSLC8A1 was significantly down-regulated in breast cancer tissues and cell lines, of which expression was negatively correlated with clinical severity and dismal prognosis. In summary, circSLC8A1/miR-671 regulates breast cancer progression through PTEN/PI3k/Akt signaling, which may provide efficient therapeutic target for this devastating cancer. We demonstrated that circSLC8A1 was significantly down-regulated in breast cancer tissues and cell lines, of which expression was negatively correlated with clinical severity and dismal prognosis. Yes Overexpression of circSLC8A1 suppressed cell proliferation, migration and invasion in vitro, and inhibited tumor growth in vivo. 33301895 circCER CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[miR‑136/MMP13 axis] CCK8//qRT-PCR//Western Blot The results revealed that circRNA‑CER and matrix metalloproteinase 13 (MMP13) were Expression[Expression[up-expression]-expression]regulated, whereas miR‑136 was Expression[down-expression]regulated in breast cancer tissues compared with adjacent non‑tumor tissues. Yes the results demonstrated that silencing of circRNA-CER efficiently sExpression[Expression[up-expression]-expression]pressed the expression of circRNA-CER (Fig. 2B). In addition, the results from the CCK-8 and Transwell assays indicated that knockExpression[down-expression] of circRNA-CER significantly sExpression[Expression[up-expression]-expression]pressed proliferation (Fig. 2C) and migration (Fig. 2D) of MCF-7 cells. 30816475 circASS1 CircRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Microarray CircASS1 in MDA-MB-231 is Expression[down-expression]regulated comparing to MCF-7, and overexpression of circASS1 could sExpression[Expression[up-expression]-expression]press invasion and migration. While silence, it could promote invasion and migration. Yes CircASS1 in MDA-MB-231 is Expression[down-expression]regulated comparing to MCF-7, and overexpression of circASS1 could sExpression[Expression[up-expression]-expression]press invasion and migration. While silence, it could promote invasion and migration. 30657346 circPRMT5 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells regulation[ circ-PRMT5/miR-509-3p/TCF7L2 axis] Flow Cytometry//qRT-PCR//Luciferase Report Assay//RNA Pull-Down Circ-PRMT5 is up-regulated in breast cancer tissues and cells. Overall, our data indicate that the circ-PRMT5/miR-509-3p/TCF7L2 axis can aggravate the malignant character of breast cancer cells by the regulation of the PI3K/AKT pathway. Yes Functionally, knockdown of circ-PRMT5 suppresses cell proliferation and angiogenesis and increases cell apoptosis in breast cancer. 33277756 hsa_circ_001783 CircRNA Homo sapiens Breast Neoplasms breast cancer tissue,cell line Interaction[sponging miR-200c-3p] RIP//Luciferase Report Assay  Here we systematically analyzed the circular RNAs in breast cancer based on their characteristic in sponging disease-specific miRNAs and identified hsa_circ_001783 as a top ranked circRNA in our computation and verified its high expression in both breast cancer cells and cancer tissue. .Importantly, hsa_circ_001783 promoted progression of breast cancer cells via sponging miR-200c-3p. Yes Knockdown of this circRNA remarkably inhibited the proliferation and invasion of breast cancer cells. 30670688 circPGD CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-16-5p/ABL2) Western Blot//Wound Healing Assay//Migration Assay//CCK8//FISH//qRT-PCR//Flow Cytometry//IF//Luciferase Report Assay//IHC//Transwell Assay Compared with the control, circPGD and ABL2 expression increased within GC tissues and cells, and the miR-16-5p level was decreased. Mechanistically, circPGD sponged miR-16-5p for relieving miR-16-5p suppression on the corresponding target ABL2 via the SMAD2/3 and YAP signaling pathways. Yes Functionally, circPGD promoted cell proliferation, migration and suppressed apoptosis in vitro. 36104322 circSKA3 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-520h/CDC42) Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Overexpression of circ_SKA3 was validated in GC tissues and cells. Circ_SKA3 directly bound to miR-520h, and circ_SKA3 regulated CDC42 expression through miR-520h. Circ_SKA3 exerted regulatory effects on GC cell behaviors by inhibiting miR-520h. Furthermore, CDC42 was a functional target of miR-520h in regulating GC cell behaviors. Yes The down-regulation of circ_SKA3 suppressed proliferation, cell cycle progression, colony formation, migration, invasion, and promoted cell apoptosis in vitro, as well as weakening tumor growth in vivo. 36134741 circRPPH1 CircRNA Homo sapiens Stomach Neoplasms gastric cancer cells Interaction(miR-375/SLC7A11 axis) RIP//Luciferase Report Assay Moreover, circRPPH1 promoted the stemness of gastric cancer cells dependent on the miR-375/SLC7A11. Yes Moreover, circRPPH1 promoted the stemness of gastric cancer cells dependent on the miR-375/SLC7A11. 36190453 circDNMT1 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction( miR-576-3p/HIF-1α axis ) RNA Pull-Down//Western Blot//Migration Assay//CCK8//FISH//qRT-PCR//Luciferase Report Assay//Invasion Assay circDNMT1 was successfully identified and shown to be overexpressed in GC tissues and cell lines. circDNMT1 functioned as an oncogenic factor by sponging miR-576-3p. HIF-1α was negatively regulated by miR-576-3p via binding its mRNA 3' untranslated region. circDNMT1 promoted malignant behaviors and metabolic reprogramming of GC by targeting the miR-576-3p/HIF-1α axis both in vitro and in vivo. The expression levels of circDNMT1 were correlated with pathological T stage, pathological TNM stage and shorter survival time of GC patients. Yes circDNMT1 knockdown inhibited the proliferation, migration, invasion and glycolysis of GC cells. 35712504 hsa_circ_0005758 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-1229-3p/GCNT4 feedback loop) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Circ_0005758 expression was decreased in GC tissues and cells, re-expression of circ_0005758 induced apoptosis and suppressed proliferation, migration, invasion and angiogenesis in GC cells in vitro, and impeded xenograft tumor growth in nude mice. Circ_0005758 acts as a tumor suppressor to impede gastric cancer progression via miR-1229-3p/GCNT4 axis, implying that therapeutic targeting of circ_0005758 may better to prevent gastric cancer. Yes Circ_0005758 expression was decreased in GC tissues and cells, re-expression of circ_0005758 induced apoptosis and suppressed proliferation, migration, invasion and angiogenesis in GC cells in vitro, and impeded xenograft tumor growth in nude mice. 35970245 hsa_circ_0017728 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-149/IL-6/STAT3 signaling pathway) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay Our results demonstrated that the hsa_circ_0017728 expression level was up-regulated in GC tissues and cell lines and closely associated with poor overall survival and pathological differentiation, higher TNM stage and lymph node metastasis. We also discovered that hsa_circ_0017728 might serve as a ceRNA to sponge miR-149 and indirectly regulated the IL-6/STAT3 signaling pathway in GC cell proliferation and apoptosis. Our results demonstrated that the hsa_circ_0017728 expression level was up-regulated in GC tissues and cell lines and closely associated with poor overall survival and pathological differentiation, higher TNM stage and lymph node metastasis. Yes . Knockdown of hsa_circ_0017728 had the ability to cause inhibition of cell proliferation and migration and elevate the cell apoptosis rate in GC cells. 36457988 circCOL1A2 CircRNA Homo sapiens Stomach Neoplasms GC cells Interaction(miR-1286/USP10/RFC2 ) RNA Pull-Down//Western Blot//Wound Healing Assay//Co-IP//qRT-PCR//FISH//RIP//IF//Luciferase Report Assay//Transwell Assay Our results found circCOL1A2 to be not only upregulated in GC cells, but that it also propels the migration and invasion of GC cells. CircCOL1A2 functions as a competing endogenous RNA (ceRNA) by sequestering microRNA-1286 (miR-1286) to modulate ubiquitin-specific peptidase 10 (USP10), which in turn spurs the migration and invasion of GC cells by regulating RFC2.CircCOL1A2 sponges miR-1286 to promote cell invasion and migration of GC by elevating the expression of USP10 to downregulate the level of RFC2 ubiquitination. Yes Our results found circCOL1A2 to be not only upregulated in GC cells, but that it also propels the migration and invasion of GC cells. CircCOL1A2 sponges miR-1286 to promote cell invasion and migration of GC by elevating the expression of USP10 to downregulate the level of RFC2 ubiquitination. 35791074 circSFMBT2 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cells Interaction(miR-885-3p/CHD7 pathway) Wound Healing Assay//Colony Formation Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Transwell Assay Circ-SFMBT2 and CHD7 were upregulated, whereas miR-885-3p was downregulated in gastric cancer tissues and cells. In mechanism analysis, circ-SFMBT2 regulated CHD7 expression by sponging its target miRNA, miR-885-3p. Rescue experiments manifested that miR-885-3p inhibition reversed the effects of circ-SFMBT2 knockdown, and CHD7 overexpression abolished the antitumor role of miR-885-3p overexpression. Moreover, circ-SFMBT2 knockdown inactivated the Wnt/β-catenin signaling pathway. Yes In functional assay, circ-SFMBT2 knockdown suppressed gastric cancer cell viability, colony formation ability, migration, invasion and oxidative stress but induced apoptosis, and circ-SFMBT2 downregulation also blocked tumor growth in vivo. 34387601 hsa_circ_0000218 CircRNA Homo sapiens Stomach Neoplasms GC cells Interaction(hsa_circ_0000218/hsa-miR-139-3p/SOX4 ) RNA Pull-Down//Western Blot//Luciferase Report Assay//qRT-PCR circ_0000218 and SOX4 were highly expressed, whereas miR-139-3p was lowly expressed in GC cells.Moreover, circ_0000218 negatively regulated miR-139-3p in GC cells. miR-139-3p overexpression inhibited proliferation and induced apoptosis in GC cells, but these effects were reversed by SOX4 overexpression. Yes circ_0000218 knockdown inhibited GC cell proliferation, promoted apoptosis and enhanced cleaved-Caspase3 expression in GC cells, whereas miR-139-3p knockdown reversed these effects. 35185288 hsa_circ_0005230 CircRNA Homo sapiens Stomach Neoplasms 130 cases of GC tissues and cell line Interaction(miR-1299/RHOT1 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay This study validated that hsa_circ_0005230 was significantly up-regulated in 130 cases of GC tissues using qRT-PCR, and clinicopathological feature analysis revealed that its high expression was positively associated with histological grade, lymph node metastasis, TNM stages, and poor prognosis. In mechanism studies, bioinformatics analyses were used to predict the hsa_circ_0005230/miR-1299/RHOT1 axis and hsa_circ_0005230 may serve as a sponge for miR-1299 and indirectly regulate the expression of RHOT1. The regulated relationships between the molecules on the axis were verified using qRT-PCR and correlation analysis. Dual-luciferase reporter gene assay has been used to verify the binding site between miR-1299 and RHOT1. WB (Western blotting) and IHC (Immunohistochemical) were used to verify that RHOT1 may play the role of oncoprotein and affect the biological behavior of GC. This study validated that hsa_circ_0005230 was significantly up-regulated in 130 cases of GC tissues using qRT-PCR, and clinicopathological feature analysis revealed that its high expression was positively associated with histological grade, lymph node metastasis, TNM stages, and poor prognosis. Yes In vitro, functional experiments showed that silencing hsa_circ_0005230 significantly decreased GC cell proliferation, invasion and migration capabilities. In addition, the major proteins of EMT (epithelial-mesenchymal transition) relevance have changed. 35170374 hsa_circ_0006282 CircRNA Homo sapiens Stomach Neoplasms gastric cancer cells, gastritis tissues, and gastric cancer tissues Interaction(hsa-miR-136-5p/PTEN/AKT pathway) Western Blot//CCK8//qRT-PCR//RIP//Colony Formation Assay//EdU Staining//Transwell Assay Hsa_circ_0006282 was down expressed in gastric cancer cells, gastritis tissues, and gastric cancer tissues. Besides, Western blot showed that the levels of protein kinase B (AKT) and cyclin-dependent kinase 2 (CDK2) were significantly increased and decreased after knockdown and up-regulation of hsa_circ_0006282, respectively, while phosphatase and tensin homolog deleted on chromosome ten (PTEN) was significantly opposite regulated. Finally, hsa_circ_0006282 promoted the expression of PTEN by sponging hsa-miR-136-5p. Yes The abilities of cell proliferation, cell migration and resistance to apoptosis were enhanced after hsa_circ_0006282 was downregulated, while overexpression of hsa_circ_0006282 got opposite results. 35794253 hsa_circ_0006470 CircRNA Homo sapiens Stomach Neoplasms AGS cells Interaction(miR-1234/TP53I11 axis) Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//EdU Staining//Transwell Assay The data indicated that hsa_circ_0006470 expression was downregulated in AGS cells. Moreover, miR-1234 was bound to hsa_circ_0006470 and TP53I11 was targeted by miR-1234. Furthermore, OE of hsa_circ_0006470 inhibited the tumorigenesis of GC via the regulation of the miR-1234/TP53I11 axis. Yes In addition, overexpression (OE) of hsa_circ_0006470 could inhibit the viability and proliferation of GC cells. Moreover, OE of hsa_circ_0006470 inhibited the migration of GC cells and induced G1 cell cycle phase arrest. 36190397 hsa_circ_0075825 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-432-5p/SOX9) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Circ_0075825 expression was raised in GC tissues and cell lines. SOX9 was identified as one of the direct target genes of miR-432-5p, and circ_0075825 repressed the expression of miR-432-5p, to induce the expression of SOX9. Furthermore, miR-432-5p overexpression counteracted the promoting effect of circ_0075825 on the malignancy of GC cells. Yes Circ_0075825 overexpression promoted the proliferative, migrative and invasive abilities of GC cells, while inhibiting apoptosis, while depletion of circ_0075825 suppressed the malignant biological behaviors of GC cells. 35395444 hsa_circ_0001190 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-586/SOSTDC1 Axis) RNA Pull-Down//Western Blot//Tube Formation Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay The levels of circ_0001190 and SOSTDC1 were downregulated, and the miR-586 level was increased in GC. Circ _0001190 served as a miR-586 sponge to adjust the expression of SOSTDC1. Additionally, miR-586 could promote the advancement of GC by interfering SOSTDC1. Exosomal circ_0001190 overexpression inhibited the development of GC by miR-586/SOSTDC1 axis, which proposed a potential targeted therapy for GC cure. Yes For functional assay, circ _0001190 overexpression inhibited cell vitality, cell proliferation, angiogenesis, cell migration and invasion, whereas stimulated cell apoptosis in GC cells. 35138469 hsa_circ_0110940 CircRNA Homo sapiens Stomach Neoplasms human gastric cancer cells Interaction(miR-1178-3p/SLC38A6 Axis) CCK8//qRT-PCR//Luciferase Report Assay//Western Blot We found the significant upregulation of circ_0110940 in human gastric cancer cells AGS and MKN45. Circ_0110940 binded with miR-1178-3p, which further targeted SLC38A6 3'UTR. Circ_0110940 degraded miR-1178-3p, and miR-1178-3p degraded SLC38A6. Thus, circ_0110940 has a positive effect on SLC38A6 expression. Yes Circ_0110940 was a stable circRNA and exerted an antiproliferative and proapoptotic effect in AGS and MKN45. 35813866 circPFKP CircRNA Homo sapiens Stomach Neoplasms GC tissues & GC cells Interaction(miR-644 and regulating ADAMTSL5 expression) RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircPFKP is downregulated in GC tissues, and overexpression of circPFKP inhibits malignant behavior in GC cells. Bioinformatics predicted that circPFKP could bind to miR-644, and miR-644 could target disintegrin-like and metalloprotease domain-containing thrombospondin type 1 motif-like 5 (ADAMTSL5). Overexpression of circPFKP enhances the expression of ADAMTSL5 by decreasing the expression of miR-644 to suppress the growth of xenograft GC tumors in vivo and in vitro. In conclusion, the circPFKP/miR-644/ADAMTSL5 regulatory pathway inhibited the malignant progression of GC. These findings may extend our understanding of the effects of circRNAs on cancer development and provide novel targets for the diagnosis of GC. Yes Overexpression of circPFKP enhances the expression of ADAMTSL5 by decreasing the expression of miR-644 to suppress the growth of xenograft GC tumors in vivo and in vitro. 35587154 hsa_circ_0001658 CircRNA Homo sapiens Stomach Neoplasms GC tissues and GC cell lines Interaction(miR-182/RAB10) Flow Cytometry//qRT-PCR//Cell Viability Assay//Western Blot Circ_0001658 was identified to be aberrantly expressed in GC tissues and was demonstrated in GC cell lines (AGS and HGC27) in vitro.MiR-182 bound to circ_0001658 and RAB10. Moreover, upregulated RAB10 neutralized the effects of miR-182 on cell viability, autophagy, and apoptosis of GC cells. Silencing circ_0001658 restrained cell viability, suppressed autophagy, and promoted apoptosis of GC cells by sponging miR-182 to suppress the expression of RAB10. Therefore, circ_0001658 may be a potential therapeutic target for GC. Yes Circ_0001658 and RAB10 were upregulated, whereas miR-182 was suppressed in AGS and HGC27 cells. GC cell viability and autophagy were inhibited and apoptosis was promoted after circ_0001658 knockdown, and the cellular functions were reversed by downregulating miR-182. 35030981 hsa_circ_0005230 CircRNA Homo sapiens Breast Neoplasms BC tissue specimens and cell lines Regulation[miR-618/ CBX8 Signal Pathway] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay circ_0005230 was overexpressed in BC tissue specimens and cell lines.circ_0005230/miR-618/CBX8 axis might play a key role in BC tumorigenesis and development. In addition, circ_0005230 could be regarded as a prognostic predictor in BC patients. Yes In vitro and in vivo data demonstrated the cell growth promoting role of circ_0005230. 30504704 hsa_circ_0052112 CircRNA Homo sapiens Breast Neoplasms MDA-MB-231 cells interaction[miR-125a-5p] qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay Hsa_circ_0052112 expression was significantly higher in MDA-MB-231 cells than that in MCF-7 cells.Hsa_circ_0052112 could directly sponge to miR-125a-5p; overexpression of miR-125a-5p significantly inhibited breast cancer cells migration and invasion. Yes Overexpression of hsa_circ_0052112 promoted cell migration and invasion in breast cancer. Inversely, down-regulation of hsa_circ_0052112 suppressed breast cancer cells migration and invasion. 30257349 circPLK1 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[miR-4500/IGF1 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay CircPLK1 and IGF1 were upregulated and miR-4500 was downregulated in BC tissues and cells. CircPLK1 silence inhibited BC cell growth, migration and invasion by regulating miR-4500/IGF1 axis, suggesting circPLK1/miR-4500/IGF axis might be a potential therapeutic target. Yes Interference of circPLK1 inhibited BC cell growth, migration and invasion, which was reversed by overexpression of IGF1. 33298061 circUBR1 CircRNA Homo sapiens Breast Neoplasms BC tumor tissues regulation[miR-1299/CCND1 axis] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Transwell Assay Our results revealed that circ-UBR1 was upregulated in BC, and its silencing could inhibit BC cell proliferation, metastasis, and promote apoptosis in vitro, as well as restrain BC tumor growth in vivo.Our data indicated that circ-UBR1 might play a pro-cancer role in BC progression by regulating the miR-1299/CCND1 axis. Yes Our results revealed that circ-UBR1 was upregulated in BC, and its silencing could inhibit BC cell proliferation, metastasis, and promote apoptosis in vitro, as well as restrain BC tumor growth in vivo. 33259864 circPTCD3 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction(miR-198) In Vivo Experiment//RNA Pull-Down//IHC//Wound Healing Assay//FISH//MTT//Luciferase Report Assay//PCR//Colony Formation Assay//Transwell Assay In the present study, we identified a novel circRNA termed as circPTCD3 which was indicated to be significantly up-regulated in breast cancer tissues and cell lines. Furthermore, we identified that circPTCD3 was able to target miR-198 in breast cancer cell. miR-198 has the function of inhibiting proliferation and migration of breast cancer cells which can be reversed by circPTCD3. Yes The results revealed that ectopic expression of circPTCD3 promoted the cell proliferation, migration and colony formation ability of breast cancer cells. Constantly, silencing of circPTCD3 inhibited those of breast cancer cells. 34785951 circKIF4A CircRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[miR-152/ZEB1 axis] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay CircKIF4A and ZEB1 were conspicuously upregulated and miR-152 was markedly reduced in BC tissues and cells. Silencing of circKIF4A hampered cell metastasis and promoted apoptosis by regulating ZEB1 via sponging miR-152 in BC. Yes Deficiency of circKIF4A repressed migration, invasion and induced apoptosis of BC cells. 32408908 hsa_circ_103809 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues regulation[PI3K/AKT signaling pathway] CCK8//qRT-PCR//Colony Formation Assay//Western Blot The expression of circ_103809 in breast cancer was overexpressed.circ_103809 accelerated breast cancer progression via regulating PI3K/AKT signaling. Yes circ_103809 was proved to promote cell proliferation in breast cancer progression. In addition, circ_103809 was also involved in repressing cell apoptosis and accelerating cell cycle progression in vitro. 32382325 circNFIC CircRNA Homo sapiens Breast Neoplasms breast cancer tissues interaction[sponging miR-658] qRT-PCR Our study highlighted the regulatory function of the circNFIC/miR-658/UPK1A pathway in breast cancer progression, which could be a potential therapeutic target for breast cancer. Kaplan-Meier survival analysis revealed that low levels of circNFIC were related to poor outcome of breast cancer. Yes Further experiments revealed that overexpressing circNFIC suppressed breast cancer cell proliferation and migration to the lung. 32368305 circHMCU CircRNA Homo sapiens Breast Neoplasms cell line and breast cancer tissues interaction[let-7 Family] Western Blot//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//EdU Staining In the present study we found a circRNA termed circHMCU whose expression was associated with poor prognosis. It was upregulated in cell lines with high metastatic potential compared with its parental cell line and in breast cancer tissues compared with normal tissues. Finally, let-7 microRNAs could rescue the functions of circHMCU in breast cancer via suppressing the expression of MCY, HMGA2, and CCND1. Yes In vitro results proved that circHMCU could significantly promote proliferation, migration, and invasion abilities of breast cancer cells via affecting the G1 phase cell cycle checkpoint and the epithelial-mesenchymal transition (EMT) pathway. Further in vivo studies showed that overexpression of circHMCU contributed to rapid proliferation and lung metastasis of breast cancer. 32330870 circSCYL2 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Expression[lower expressed] qRT-PCR//RNA-seq//Transwell Assay The current study identified that circSCYL2 was downregulated in breast cancer tissues and cell lines, and that circSCYL2 overexpression inhibited cell migration and invasion. Yes The current study identified that circSCYL2 was downregulated in breast cancer tissues and cell lines, and that circSCYL2 overexpression inhibited cell migration and invasion. 32236616 circCDYL CircRNA Homo sapiens Breast Neoplasms BC tissues regulation[miR-1275-ATG7/ULK1-autophagic axis ] Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay An autophagy associated circRNA circCDYL was elevated by 3.2 folds in BC tissues as compared with the adjacent non-cancerous tissues, circCDYL promotes BC progression via the miR-1275-ATG7/ULK1-autophagic axis and circCDYL could act as a potential prognostic and predictive molecule for breast cancer patients. Yes Moreover, circCDYL enhanced the malignant progression of BC cells in vitro and in vivo. 32213200 hsa_circ_0068033 CircRNA Homo sapiens Breast Neoplasms BC tissues regulation[hsa_circ_0068033/miR-659 axis] ISH//qRT-PCR The results suggested that the expression of hsa_circ_0068033 was downregulated in BC tissues, and its expression was markedly correlated with tumor size (P=0.021), and the Tumor, Node, and Metastasis stage (P=0.023). Collectively, this study revealed for the first time that hsa_circ_0068033 acts as a tumor suppressor gene in BC, and the hsa_circ_0068033/miR-659 axis participates in the progression of BC. The results suggested that the expression of hsa_circ_0068033 was downregulated in BC tissues, and its expression was markedly correlated with tumor size (P=0.021), and the Tumor, Node, and Metastasis stage (P=0.023). Yes Functionally, in-vitro experiments demonstrated that overexpression of hsa_circ_0068033 could inhibit the growths, clone formation, invasion and migration of MCF-7 and MDA-MB-231 cells while activating the intrinsic apoptotic pathway to induce apoptosis. 32184627 hsa_circ_0008039 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[miR-515-5p/CBX4 axis] RNA Pull-Down//Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay Hsa_circ_0008039 was upregulated in BC tissues and cells, and expedited proliferation, migration and invasion of BC cells. These findings implicated that hsa_circ_0008039 contributed to proliferation, migration and invasion in vitro and promoted tumor growth in vivo by miR-515-5p/CBX4 axis in BC, suggesting a potential therapeutic strategy for BC treatment. Yes CBX4 was highly expressed in BC tissues and cells, and contributed to proliferation, migration and invasion of BC cells. 32141558 circRNF20 CircRNA Homo sapiens Breast Neoplasms BC samples regulation[ miR-487a/HIF-1α/HK2] Microarray CircRNA microarray sequencing revealed that circRNF20 was one of the upregulated transcripts in BC samples.In conclusion, this finding illustrates the vital roles of circRNF20 via the circRNF20/ miR-487a/HIF-1α/HK2 axis in breast cancer progress and Warburg effect, providing an interesting insight for the BC tumorigenesis. Increased circRNF20 level predicted the poor clinical outcome in BC specimens. Yes Functionally, circRNF20 promoted the proliferation and Warburg effect (aerobic glycolysis) of BC cells. 32094325 hsa_circ_0007255 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[miR-335-5p/SIX2 axis] Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0007255 and SIX2 were overexpressed, but miR-335-5p was diminished in BC tissues and cells.Circ_0007255 functioned as a novel oncogene in the progression of BC by regulating miR-335-5p/SIX2 axis, and might be a promising biomarker for BC treatment. Yes Circ_0007255 absence inhibited oxygen consumption, colony formation, cell migration and invasion, and these effects were particularly abrogated via miR-335-5p upregulation in BC cells. 31962380 circVAPA CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells interaction[sponging miR-130a-5p] qRT-PCR//Wound Healing Assay//MTT//Transwell Assay We discovered that circVAPA was dysregulated in breast cancer tissues and cells.CircVAPA may promote migration and invasion capacity of breast cancer via harboring miR-130a-5p. Yes Ectopic circVAPA regulated breast cancer migration, invasion and proliferation. 31920104 circNFATC3 CircRNA Homo sapiens Breast Neoplasms cell lines  Regulation(up regulation) Migration Assay//CCK8//qRT-PCR//RNA-seq//Invasion Assay Breast and ovarian cancer cells showed a greater abundance of circNFATC3 compared to normal breast cell lines, lung fibroblast cells, and LCL cells. Yes The knockdown of circNFATC3 induces a reduction in cell proliferation, invasion, migration, and oxidative phosphorylation. Gain-of-function of circNFATC3 in MDA-MB-231 and SK-OV-3 cells show a significant increase in cell proliferation, migration, and respiration. 33816459 circSCRIB CircRNA Homo sapiens Breast Neoplasms breast cancer specimens Expression [highly expressed] RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//cell invasion assay//Colony Formation Assay Among these three circRNAs, circSCRIB (hsa_circ_0001831) was the most enriched in the breast cancer panel. Yes To test this, we generated a hsa_circ_0001831 expression construct. We found that there was decreased SCRIB mRNA production but increased cancer cell proliferation, migration, and invasion. In comparison, an exonic sequence construct did not affect mRNA splicing but decreased protein translation, leading to increased E-cadherin expression and decreased expression of N-cadherin and vimentin.  34365033 circMMP11 CircRNA Homo sapiens Breast Neoplasms LR breast cancer tissues and cells Interaction(MiR-1307-3p/SMG1 Axis) RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ-MMP11 and ANLN were highly expressed, and miR-153-3p was decreased in LR breast cancer tissues and cells. Yes Furthermore, circ-MMP11 knockdown promoted lapatinib sensitivity by repressing cell viability, colony number, migration, invasion, and boosting apoptosis in LR breast cancer cells. Circ-MMP11 deficiency improved the drug sensitivity of breast cancer in vivo.  34295807 circNINL CircRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction(miR-921/ADAM9 axis) RNA Pull-Down//Western Blot//Co-IP//Migration Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay We found that the expression of circNINL increased while the expression of miR-921 decreased in BC tissues and cell lines, and their anomalous expressions were associated with malignant features and poor prognostic of BC. We found that the expression of circNINL increased while the expression of miR-921 decreased in BC tissues and cell lines, and their anomalous expressions were associated with malignant features and poor prognostic of BC. Yes Then, we demonstrated that circNINL could interact with miR-921 and facilitate BC cells malignant process including proliferation acceleration, migration enhancement and apoptosis evasion via sponging miR-921 in vitro. 33479730 circSEPT9 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(microRNA-149-5p ) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC Results showed that circSEPT9 and SLC1A5 expression were significantly upregulated, while miR-149-5p was downregulated in BC tissues and cells as compared with paracancerous normal breast tissues and human normal breast cells. Yes Knockdown of circSEPT9 or SLC1A5 inhibited glutamine uptake and cell proliferation, but induced cell apoptosis in BC cells. SLC1A5 overexpression relieved circSEPT9 silencing-induced repression of BC cell malignancy. 34738502 circRASSF2 CircRNA Homo sapiens Breast Neoplasms The paired samples of 70 BC Interaction(miR-1205/HOXA1 axis) Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay According to our study, it is found that circRASSF2 sequences contain miR-1205 binding sites, and Homeobox gene A1 (HOXA1) is the target gene of miR-1205. Additionally, it is found that circRASSF2 expression had a positive correlation with distant metastasis, lymph node metastasis, TNM stage, differentiation and tumor size, and that overall survival (OS) and progression-free survival (PFS) of circRASSF2 high expression BC patients were inferior to those with low circRASSF2 expression.  Yes  In vitro study, an overt decrease was detected in the proliferation, clone formation ability, migration and invasion of breast cancer cells in cells when circRASSF2 was knocked down. 34180753 circTPGS2 CircRNA Homo sapiens Breast Neoplasms metastatic BC tissues and cell lines Interaction(miR-7/TRAF6/NF-κB axis) ChIP//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay High circ-TPGS2 was observed in metastatic BC tissues and cell lines in comparison to respective normal controls, which was linked to poor overall and recurrence-free survival. In terms of mechanism, circ-TPGS2 acted as a sponge of miR-7 and elevated TRAF6, leading to p65 phosphorylation and nuclear translocation, ultimately activating NF-κB signalling. which was linked to poor overall and recurrence-free survival. Yes Overexpression of circ-TPGS2 notably promoted cell migration, while silencing of circ-TPGS2 resulted in an opposite trend. 34036857 hsa_circ_0103552 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(MicroRNA-515-5p) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Circ_0103552 expression was found to be remarkably up-modulated in breast cancer tissues and cells, Mechanistically, circ_0103552 could sponge miR-515-5p and restrained its expression in breast cancer cells. Yes circ_0103552 overexpression facilitated the multiplication, migration, and invasion of breast cancer cells, while knocking down circ_0103552 induced the opposite effects. 34707022 hsa_circ_0000526 CircRNA Homo sapiens Breast Neoplasms breast cancer samples interaction[Sponging miR-492] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Circ_0000526 expression in breast cancer samples was downregulated, which was correlated with unfavorable pathological indexes.Circ_0000526 served as a tumor suppressor, which could function as the sponge of miR-492, an oncogenic microRNA, in breast cancer, and enhance the expression of tumor suppressor SOCS2 indirectly. Yes It significantly inhibited the proliferation and metastasis of breast cancer cells, and facilitated apoptosis. 32391718 hsa_circ_0000515 CircRNA Homo sapiens Breast Neoplasms BC tissues regulation[microRNA-296-5p/CXCL10 axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down We collected 340 cancerous tissues surgically resected from BC patients and found hsa_circ_0000515 was upregulated in BC tissues and associated with poor prognosis of BC.RNA pull-down and dual-luciferase reporter gene assays showed that hsa_circ_0000515 binds miR-296-5p, preventing it from repressing CXCL10 expression. Yes Silencing of hsa_circ_0000515 impaired cell cycle progression, cell proliferation, and invasion, attenuated inflammatory response, and reduced the proangiogenetic potential of BC cells. 32446265 hsa_circ_0008039 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[miR-140-3p/SKA2 axis] Western Blot//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay We found that circ_0008039 and SKA2 were upregulated in BC tissues and cells, while miR-140-3p was downregulated. In conclusion, circ_0008039 downregulation suppressed BC cell proliferation, migration, invasion, and glycolysis partially through regulating the miR-140-3p/SKA2 axis, providing an important theoretical basis for treatment of BC. Yes Knockdown of circ_0008039 suppressed BC cell proliferation, migration, invasion, and glycolysis. 33244865 hsa_circ_103809 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues regulation[Sponging MicroRNA-532-3p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay Then, our data showed that circRNA_103809 was down-regulated in breast cancer tissues in contrast to adjacent non-tumor tissues, and the relative expression level of circRNA_103809 was closely associated with distant metastasis size, TNM stage, HER-2 status and overall survival time. Taken together, this study showed that circRNA_103809 could inhibit cell proliferation and metastasis in breast cancer by sponging miR-532-3p, and circRNA_103809 might be a prospective target of breast cancer therapy. Then, our data showed that circRNA_103809 was down-regulated in breast cancer tissues in contrast to adjacent non-tumor tissues, and the relative expression level of circRNA_103809 was closely associated with distant metastasis size, TNM stage, HER-2 status and overall survival time. Yes In addition, our in vitro assays showed that the overexpression of circRNA_103809 could significantly inhibit epithelial-mesenchymal transition (EMT) pathway, then suppress breast cancer cell proliferation and metastasis ability. 32499818 hsa_circ_0061825 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[miR-593-3p/FGFR3 axis] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our data indicated that circ_0061825 was overexpressed in BC tissues and cells, and it was mainly localized in the cytoplasm of BC cells. Our current work provided evidence that circ_0061825, an up-regulated circRNA in BC, regulated BC malignant progression at least in part through targeting the miR-593-3p/FGFR3 axis, illuminating a novel therapeutic target for BC management. Yes Circ_0061825 knockdown hampered BC cell viability, colony formation, migration, invasion, cell cycle progression and enhanced cell apoptosis in vitro and weakened tumor growth in vivo. 33177875 hsa_circ_0072995 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines interaction[sponging miR-149-5p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Circ_0072995 and SHMT2 were up-regulated in breast cancer tissues and cell lines.This study demonstrated that circ_0072995 promoted cell malignant phenotypes and anaerobic glycolysis in breast cancer via up-regulating SHMT2 through sponging miR-149-5p, indicating a promising molecular target for breast cancer treatment. Yes Circ_0072995 and SHMT2 were up-regulated in breast cancer tissues and cell lines, and knockdown of circ_0072995 or SHMT2 suppressed cell malignant properties and anaerobic glycolysis; importantly, SHMT2 overexpression attenuated the anticancer action of circ_0072995 knockdown in breast cancer.Additionally, xenograft analysis showed circ_0072995 silencing suppressed tumor growth via regulating SHMT2 and miR-149-5p in vivo. 33173349 hsa_circ_0003645 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines regulation[miR-139-3p/HMGB1 Axis] Flow Cytometry//qRT-PCR//Luciferase Report Assay Circ_0003645 expression was conspicuously increased in both the breast cancer tissues and cell lines.Circ_0003645 functions as a ceRNA for miR-139-3p, which could upregulate HMGB1 and further promote cell proliferation in breast cancer. Yes Circ_0003645 knockdown inhibited cell proliferation and induced the apoptosis of breast cancer cells in vitro and in vivo. 33116616 hsa_circ_0001785 CircRNA Homo sapiens Breast Neoplasms BC cells regulation[miR-942/SOCS3 signaling axis] Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay "Results showed that the expressions of hsa_circ_0001785 were decreased in BC cells. In general, circular RNA hsa_circ_0001785 inhibits the proliferation, migration and invasion of BC cells by modulating the miR-942/SOCS3 signaling axis. " Yes Hsa_circ_0001785 overexpression inhibited the proliferation, migration, invasion of BC cells and tumor growth in nude mice. 33054543 hsa_circ_0000043 CircRNA Homo sapiens Breast Neoplasms BC tissues and cell lines regulation[miR-136-Smad3 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay Our results show that the expression of circ_0000043 is up-regulated in BC tissues and cell lines. In conclusion, our study demonstrates that circ_0000043 promote the progression of BC via regulating the miR-136-Smad3 axis. Yes The proliferation, migration, invasiveness, and epithelial-mesenchymal transition of BC cells were significantly inhibited by knockdown of circ_0000043, and overexpression of circ_0000043 had the opposite effects. 33043682 circABCC4 CircRNA Homo sapiens Breast Neoplasms tumor tissues regulation[NF-κB and Wnt/β-catenin signal pathways] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The expression of circABCC4 was far great in tumor tissues than in normal tissues.CircABCC4 knockdown repressed breast cancer cells viability, migration, and invasion by up-regulating miR-154-5p via inhibiting NF-κB and Wnt/β-catenin signal pathways. Yes Knockdown of circABCC4 could subdue cell viability, migration, invasion, and enhance apoptosis in breast cancer cell lines. 33023375 hsa_circ_0000518 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[miR-326/FGFR1 axis] CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0000518 and FGFR1 were upregulated while miR-326 was downregulated in BC tissues and cells.Circ_0000518 facilitated BC development via regulation of the miR-326/FGFR1 axis, suggesting that circ_0000518 might be a promising target for BC treatment. Yes Circ_0000518 silencing impeded tumor growth in vivo and induced cell cycle arrest, apoptosis, cured proliferation, colony formation, migration, and invasion of BC cells in vitro. 33000910 hsa_circ_002178 CircRNA Homo sapiens Breast Neoplasms cancer tissues or BrCa cells regulation[miR-1258/KDM7A Axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//H&E Staining//Colony Formation Assay//Transwell Assay In this investigation, the expression levels of circ_002178 in cancer tissues or BrCa cells were significantly upregulated compared with those in paracancer tissues or normal cells. Taken together, targeting the circ_002178/miR-1258/KDM7A axis may be a prospective strategy for the diagnosis and therapies of BrCa in the future. High expression of circ_002178 was correlated with the low survival rate, clinical tumor size, lymph node metastasis, and tumor, nodes, and metastases grade. After Yes Besides, the overexpression of circ_002178 also significantly promoted the growth, invasion, and migration of BrCa cells. 32951449 circWWC3 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues regulation[Ras signaling pathway,] Microarray circWWC3 is highly expressed in breast cancer tissues and is associated with the poor prognosis of breast cancer patients. Our findings reveal that ZEB1-mediated upregulation of circWWC3 promotes breast cancer progression through activating Ras signaling pathway, which provides a potential therapeutic target and prognostic biomarker for breast cancer. circWWC3 is highly expressed in breast cancer tissues and is associated with the poor prognosis of breast cancer patients. Yes Silencing of circWWC3 significantly suppresses the proliferation, migration, and invasion of breast cancer cells. 32916598 hsa_circ_0000291 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[miR-326/ETS1 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We demonstrated that circ_0000291 was significantly upregulated in BC, and its high expression was positively correlated with T stage and local lymph node metastasis. In conclusion, circ_0000291 is the novel oncogenic circRNA and promotes BC progression via modulating the miR-326/ETS1 axis. We demonstrated that circ_0000291 was significantly upregulated in BC, and its high expression was positively correlated with T stage and local lymph node metastasis. Yes Functional assays validated that circ_0000291 promoted BC cell proliferation, migration and invasion. 32869935 circZFR CircRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[miR-578/HIF1A axis] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay Our data indicated that circZFR was overexpressed in BC tissues and cells, and the increased circZFR level predicted poor prognosis of BC patients. Our findings first identified that the silencing of circZFR suppressed BC malignant progression in vitro via the regulation of the miR-578/HIF1A axis, providing evidence for the crucial involvement of circZFR in BC pathogenesis. Our data indicated that circZFR was overexpressed in BC tissues and cells, and the increased circZFR level predicted poor prognosis of BC patients. Yes CircZFR silencing or miR-578 overexpression repressed BC cell viability, colony formation, migration, invasion, and glycolysis and enhanced cell apoptosis in vitro. CircZFR silencing also hampered tumor growth in vivo. 32831653 circHIPK3 CircRNA Homo sapiens Breast Neoplasms BC tissues regulation[miR-193a/HMGB1/PI3K/AKT signaling] RNA Pull-Down//Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay Upregulation of CirCHIPK3 was identified in BC, which predicted a worse prognosis in BC patients.CirCHIPK3 regulated miR-193a/HMGB1/PI3K/AKT signaling to facilitate BC development and progression, providing a novel therapeutic target for BC. Upregulation of CirCHIPK3 was identified in BC, which predicted a worse prognosis in BC patients. Yes Furthermore, it was found that CirCHIPK3 facilitated cell proliferation, migration, and invasion in BC by regulating miR-193a/HMGB1/PI3K/AKT signaling. CirCHIPK3 acted as a sponge for miR-193a to facilitate HMGB1 expression. si-CirCHIPK3 also inhibited tumor growth of BC in nude mice. 32767499 circIQCH CircRNA Homo sapiens Breast Neoplasms breast cancer tissues regulation[circIQCH-miR-145-DNMT3A axis] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay circIQCH was upregulated in breast cancer tissues, especially in the metastatic sites. In summary, our study demonstrated the pivotal role of circIQCH-miR-145-DNMT3A axis in breast cancer growth and metastasis via the mechanism of competing endogenous RNAs. Yes Knockdown of circIQCH inhibited breast cancer cell proliferation and migration to lung. 32756009 hsa_circ_000554 CircRNA Homo sapiens Breast Neoplasms BC tissues regulation[microRNA-182/ZFP36 axis] qRT-PCR Low expression of circRNA_000554 and ZFP36, and high miR-182 expression were determined in the clinical BC tissues.Taken together, the present study confirms that circRNA_000554 functioned as an inhibitor of EMT in BC and suggests a molecular mechanism that circRNA_000554 bound to miR-182 to upregulate ZFP36 in this process. Yes After that, in order to evaluate the effects of circRNA_000554, miR-182, and ZFP36 on cellular process, we evaluated in vitro epithelial-mesenchymal transition (EMT) and in vivo tumor growth after delivering a series of overexpression plasmids, mimic, inhibitor, or shRNAs into BC cells. 32729957 hsa_circRPPH1_015 CircRNA Homo sapiens Breast Neoplasms BC tissues regulation[Impairing miRNA-326-Mediated ELK1 Inhibition] RNA Pull-Down//Western Blot//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay hsa_circRPPH1_015 expression was upregulated in BC tissues. hsa_circRPPH1_015 could bind to miRNA-326 that negatively regulates ELK1. Yes Tumor growth of MCF-7 cells in vivo was reduced in nude mice lack of endogenous hsa_circRPPH1_015 expression. 32670874 circMMP11 CircRNA Homo sapiens Breast Neoplasms breast cancer cell lines and tissues regulation[miR-1204] qRT-PCR//Luciferase Report Assay The expression of one of the top upregulated circRNAs, circMMP11, was confirmed by qRT-PCR in both breast cancer cell lines and tissues. The circMMP11/miR-1204/MMP11 axis regulates breast cancer progression via a competitive endogenous RNA (ceRNA) mechanism. Yes The inhibition of circMMP11 suppressed cell proliferation and migration of BC. 32655792 circEIF3M CircRNA Homo sapiens Breast Neoplasms breast cancer tissues regulation[circEIF3M/ miR-33a/ cyclin D1 axis] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay It was found that circEIF3M was markedly upregulated in triple-negative breast cancer as compared to adjacent nontumor tissue, These findings showed that circEIF3M promotes triple-negative breast cancer progression via the circEIF3M/ miR-33a/ cyclin D1 axis. Yes It was found that circEIF3M was markedly upregulated in triple-negative breast cancer as compared to adjacent nontumor tissue, and that circEIF3M promoted triple-negative breast cancer cell proliferation, migration, and invasion. 32652519 hsa_circ_1073 CircRNA Homo sapiens Breast Neoplasms BC cells (BCCs) and tissues Expression[lower expressed] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Colony Formation Assay//Transwell Assay Low circ-1073 expression was discovered in BCCs and BC tissues compared with normal mammary epithelial cells and peritumoural tissues, respectively. Circ-1073 downregulation was significantly associated with an unfavourable prognosis, including a shorter RFS, in BC patients. Yes Circ-1073 overexpression significantly inhibited BCC proliferation and induced apoptosis by increasing Cleaved Caspase-3/9 levels. 32636640 circDDX17 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines interaction[ miR-605 ] qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay In this study, low circDDX17 expression was observed in breast cancer tissues and cell lines.We identified the downregulation of circDDX17 in breast cancer, and circDDX17 acted as a tumour suppressor by inhibiting proliferation and promoting apoptosis through its function as a sponge of miR-605 in breast cancer, indicating that it serves as a potential biomarker and a therapeutic target for breast cancer. Moreover, circDDX17 expression was inversely associated with the clinicopathological parameters of tumour grade and advanced TNM stage (p<0.05). Yes Functionally, overexpressed circDDX17 inhibited cell proliferation and colony formation and promoted cell apoptosis in breast cancer. 32633371 hsa_circ_0119412 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-1298-5p/ZBED3 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Invasion Assay Our data revealed that hsa_circ_0119412 and ZBED3 expression was upregulated in GC, while miR-1298-5p expression was downregulated.Mechanistically, hsa_circ_0119412 sponges miR-1298-5p, which regulates ZBED3 expression. Silencing hsa_circ_0119412 inhibits the progression of GC, at least in part, by targeting the miR-1298-5p/ZBED3 axis. Yes Both the knockdown of hsa_circ_0119412/ZBED3 and miR-1298-5p overexpression inhibited GC cell growth and invasion, and enhanced cell apoptosis, while miR-1298-5p interference or ZBED3 overexpression showed the opposite trend. 35200111 hsa_circ_0000190 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-382-5p/ZNRF3) CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining Circ_0000190 was down-regulated in GC tissues and cell lines. MiR-382-5p was a target of circ_0000190, and circ_0000190 suppressed GC progression partly via serving as miR-382-5p sponge. ZNRF3 was a target of miR-382-5p, and miR-382-5p accelerated the proliferation, motility and restrained the ferroptosis of GC cells partly via regulating ZNRF3. Low expression of circ_0000190 predicted dismal prognosis in GC patients. Yes Circ_0000190 overexpression inhibited the proliferation, migration and invasion and promoted Erastin- or ras selective lethal 3 (RSL3)-mediated ferroptosis in GC cells. Circ_0000190 overexpression restrained xenograft tumor growth in vivo. 35037032 circDIDO1 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(MiR-1307-3p/SOCS2 Axis) Migration Assay//RIP//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay CircDIDO1 inhibited GC progression by regulating the expression of the signal transducer inhibitor SOSC2 through sponging miR-1307-3p. Overexpression of circDIDO1 or SOSC2 antagonized the oncogenic role of miR-1307-3p. Yes Compared with PBS and RGD-Exo-vector treatment, RGD-Exo-circDIDO1 treatment significantly inhibited the proliferation, migration and invasion of GC cells while promoted cell apoptosis. 35864511 hsa_circ_0110389 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-127-5p/miR-136-5p-SORT1 pathway) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, hsa_circ_0110389 was identified as a novel upregulated circRNA in malignant-transformed GC cells through RNA-seq, and subsequent quantitative real-time PCR verified that hsa_circ_0110389 was significantly increased in GC tissues and cells. In addition, hsa_circ_0110389 was identified to sponge both miR-127-5p and miR-136-5p and SORT1 was validated as a direct target of miR-127-5p and miR-136-5p through multiple mechanism assays; moreover, hsa_circ_0110389 sponged miR-127-5p/miR-136-5p to upregulate SORT1 expression and hsa_circ_0110389 promoted GC progression through the miR-127-5p/miR-136-5p-SORT1 pathway. Yes Knockdown and overexpression assays demonstrated that hsa_circ_0110389 regulates proliferation, migration, and invasion of GC cells in vitro. Finally, hsa_circ_0110389 knockdown suppressed GC growth in vivo. 34162830 circhsa2 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(hsa-miR-944/PPM1E axis) Western Blot//Bioinformatics Analysis//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In this study, we demonstrated that a specific circRNA, circHAS2, was upregulated in GC tissues and cells and was positively correlated with tumor metastasis.In addition, hsa-miR-944 interacted with protein phosphatase, Mg2+/Mn2+-dependent 1E (PPM1E), and was found to be a target gene of circHAS2. Yes In vitro experiments demonstrated that circHAS2 knockdown or the addition of hsa-miR-944 mimics inhibited the proliferation, migration, and invasion ability of GC cells and affected the epithelial-mesenchymal transition. The upregulation of PPM1E reversed the effects of circHAS2 knockout on GC cells. 34556632 circRNF111 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-876-3p/KLF12 ) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ-RNF111 was higher expressed in GC tissues and cells than normal tissues and cells. Circ-RNF111 positively regulated KLF12 expression via absorbing miR-876-3p. MiR-876-3p downregulation reversed the impacts of circ-RNF111 silencing on GC cell malignant phenotypes. MiR-876-3p overexpression repressed GC cell growth, metastasis and glycolysis, inhibited apoptosis and arrested cell cycle, while KLF12 elevation weakened the effects. Yes Silencing of circ-RNF111 restrained cell viability, colony formation, migration, invasion, cell cycle process and glycolysis and induced apoptosis in GC cells in vitro. Besides, circ-RNF111 knockdown inhibited tumor growth in vivo. 34461926 circBFAR CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-513a-3p/hexokinase 2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining The results showed that circBFAR exhibited higher expression in GC tissues and cell lines. circBFAR was proven to promote GC proliferation by targeting the miR-513a-3p/hexokinase 2 (HK2) axis. Yes Inhibition of circBFAR also led to a significant decrease in the glycolysis levels. 33979737 hsa_circ_0074027 CircRNA Homo sapiens Stomach Neoplasms GC cell lines Interaction(EIF4A3 ) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay The results revealed that circ_0074027 was highly expressed in GC cell lines in the form of a closed loop. Furthermore, EIF4A3 was predicted to be targeted by circ_0074027 and a positive association was identified between them. The overexpression of EIF4A3 reversed the effects of circ_0074027 on the proliferation and motility of GC cells. Yes In addition, circ_0074027-knockdown inhibited cellular proliferation and motility. 34457059 circURI1 CircRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(hnRNPM) In Vivo Experiment//RNA Pull-Down//Northern Blot//Western Blot//Wound Healing Assay//RIP//Transwell Assay CircURI1 exhibits the significantly higher expression in GC compared with paraGC and inhibitory effects on cell migration and invasion in vitro and GC metastasis in vivo. Mechanistically, circURI1 directly interacts with heterogeneous nuclear ribonucleoprotein M (hnRNPM) to modulate alternative splicing of genes, involved in the process of cell migration, thus suppressing GC metastasis. Yes CircURI1 exhibits the significantly higher expression in GC compared with paraGC and inhibitory effects on cell migration and invasion in vitro and GC metastasis in vivo. 34385309 hsa_circ_0005654 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell Interaction( miR-363 /sp1) In Vivo Experiment//ChIP//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//H&E Staining//Transwell Assay We observed that circ0005654 was enhanced in GC tissues and cells. It was also established that circ0005654 served as a miR-363 sponge and enhanced sp1 expression. Furthermore, sp1 promoted GC carcinogenesis by regulating myc transcription to potentiate the Wnt/β-catenin pathway. Overexpression of circ0005654 was correlated with a poor long-term prognosis in patients with GC. Yes . Functionally, silencing of circ0005654 remarkably suppressed GC cell proliferation, migration and invasiveness in vitro and tumorigenesis and metastases in vivo. 34499009 circCOL6A3_030 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Expression(lower expressed) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//H&E Staining//IHC//Transwell Assay circCOL6A3_030 was down-regulated in GC tissues and cell lines, while circCOL6A3_030 was up-regulated in GC with distant lymph node metastasis.To sum up, our study showed that circCOL6A3_030 promoted GC cell migration by encoding a small peptide called circCOL6A3_030_198aa. Yes The migration of circCOL6A3_030 silenced GC cells was significantly inhibited in both SGC-7901 and BGC-823 cell lines. Importantly, in vivo assay, silencing circCOL6A3_030 could reduce liver metastases from gastric cancer cells. 34595992 hsa_circ_0023409 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-542-3p/IRS4/PI3K/AKT Pathway) In Vivo Experiment//ISH//Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//FISH//Luciferase Report Assay//H&E Staining//IHC//EdU Staining//Transwell Assay The results showed that hsa_circ_0023409 was mainly located in cytoplasm and highly expressed in GC tissues and cells. Mechanism studies demonstrated that hsa_circ_0023409 upregulated IRS4 via sponging miR-542-3p in GC cells. Furthermore, IRS4 overexpression activated the PI3K/AKT pathway and reversed the inhibitory effect of hsa_circ_0023409 knockdown on the PI3K/AKT pathway. Moreover, hsa_circ_0023409 showed positive correlation with tumor size, histological grade, and tumor-node-metastasis staging of GC patients. Yes Functional studies showed that hsa_circ_0023409 promoted cell viability, proliferation, migration, and invasion and suppressed apoptosis in GC. 33439739 circAFF2 CircRNA Homo sapiens Stomach Neoplasms gastric cancer cell lines and tissues Interaction(miR-6984-5p/ ANTXR 1.) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay The result showed that circAFF2 expression was significantly increased in gastric cancer cell lines and tissues. In vivo studies showed that knockdown of circAFF2 delayed tumor growth. Furthermore, we revealed that circAFF2 functioned as a sponge to absorb miR-6984-5p and elevated the expression of ANTXR 1. Yes The knockdown of circAFF2 dramatically suppressed the cell migration, invasion and proliferation of gastric cancer cells. 33722777 hsa_circ_100290 CircRNA Homo sapiens Stomach Neoplasms GC cells and 102 GC tissues Interaction(miR-29b-3p/ITGA11 axis and is regulated by EIF4A3) Western Blot//Bioinformatics Analysis//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The expression of circRNA_100290 was significantly upregulated in GC cells and 102 GC tissues, and high circRNA_100290 expression in GC was closely related to Borrmann's type, lymph node metastasis and tumour-node-metastasis stage. Mechanistically, a dual-luciferase reporter assay confirmed the direct interaction between circRNA_100290 and miR-29b-3p, which targets ITGA11, an oncogene that is closely related to epithelial-mesenchymal transition (EMT). In addition, EIF4A3, an RNA-binding protein (RBP), could inhibit the formation of circRNA_100290 by binding to the flanking sites of circRNA_100290. The expression of circRNA_100290 was significantly upregulated in GC cells and 102 GC tissues, and high circRNA_100290 expression in GC was closely related to Borrmann's type, lymph node metastasis and tumour-node-metastasis stage. Yes In vitro, knockdown of circRNA_100290 in AGS and HGC-27 cells significantly inhibited cell proliferation, migration, and invasion. 34182990 circHN1 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-302b-3p/ROCK2 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We observed that circ_HN1 and ROCK2 were upregulated while miR-302b-3p was downregulated in GC tissues and cells. Circ_HN1 sponged miR-302b-3p to regulate ROCK2 expression. MiR-302b-3p inhibitor reversed circ_HN1 silencing-mediated influence on the malignant behaviors of GC cells. Furthermore, ROCK2 overexpression restored miR-302b-3p mimic-mediated impacts on cell malignant behaviors in GC cells. Yes Circ_HN1 silencing slowed tumor growth in vivo and impeded cell proliferation migration, invasion, and facilitated cell apoptosis in GC cells in vitro. 32949310 hsa_circ_0002570 CircRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(MiR-587/VCAN ) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Wound Healing Assay//Tunel//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ-0002570 expression was distinctly increased in GC tissues compared to adjacent normal specimens, and GC patients with higher circ-0002570 expressions displayed a short survival.Mechanistically, miR-587 was sponged by circ-0002570. VCAN expression in NSCLC was directly inhibited by miR-587. Overexpression of circ-0002570 prevented VCAN from miR-587-mediated degradation and thus facilitated GC progression. Circ-0002570 expression was distinctly increased in GC tissues compared to adjacent normal specimens, and GC patients with higher circ-0002570 expressions displayed a short survival. Yes Functionally, knockdown of circ-0002570 resulted in the inhibition of cell proliferation, migration, and invasion, and suppressed tumor growth in vivo. 34692507 circPTPDC1 CircRNA Homo sapiens Stomach Neoplasms GC cells, tissues, and serum Interaction( Mir-139-3p / ELK1) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Invasion Assay//Migration Assay//CCK8//qRT-PCR//RIP//RNA-seq//Luciferase Report Assay//Microarray//Colony Formation Assay//Bioinformatics Analysis Then we demonstrated that circ-PTPDC1 was up-regulated in GC cells, tissues, and serum. We further revealed that circ-PTPDC1 promotes the proliferation, migration, and invasion of GC cell lines via sponging miR-139-3p by regulating ELK1. Its overexpression was positively correlated with age, invasion depth, advanced clinical stages, and worse survival in patients with GC. Yes We further revealed that circ-PTPDC1 promotes the proliferation, migration, and invasion of GC cell lines via sponging miR-139-3p by regulating ELK1. Importantly, we identified that circ-PTPDC1 promotes tumor upgrowth and metabasis in vivo. 34803498 hsa_circ_0000423 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-582-3p/DIXDC1 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay In the present study, we demonstrated that circ_0000423 was highly expressed in GC. Moreover, miR-582-3p was confirmed as a direct target of circ_0000423, and an upstream regulator of DIXDC1. MiR-582-3p inhibition or DIXDC1 overexpression could reverse the above-mentioned effects of knocking down circ_0000423 on GC cells. Yes Circ_0000423 knockdown suppressed GC cell viability, migration and invasion. 34898351 hsa_circ_0021087 CircRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(miR-184/FOSB ) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//IHC//Bioinformatics Analysis//Transwell Assay Circ_0021087 and FOSB were lowly expressed in GC, whereas miR-184 had an opposite result. Circ_0021087 could elevate FOSB expression by adsorbing miR-184. MiR-184 mimic reversed the inhibitory influence of circ_0021087 overexpression on GC cell malignancy. Also, FOSB knockdown offset the suppressive impact of miR-184 silencing on GC cell malignancy. Yes Circ_0021087 overexpression repressed GC cell proliferation and epithelial-mesenchymal transition (EMT) in xenograft models in vivo and induced GC cell apoptosis, repressed GC cell proliferation, EMT, migration and invasion in vitro. 34076278 circHIPK3 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-637/AKT1 Pathway) CCK8//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay Quantitative real-time PCR (qRT-PCR) was employed to found that circHIPK3 markedly increased in GC tissues and cell lines. Then the bioinformatics tool predicted the downstream target of circHIPK3, and it was proved by the dual-luciferase report experiment. According to the results of bioinformatics analysis and experimental data, it was clarified that circHIPK3 acted as a sponge of miR-637, releasing its direct target AKT1. Yes And low expression of circHIPK3 suppressed the GC cells growing and metabolizing. 33680975 circACC1 CircRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(miR-29c-3p/FOXP1 network ) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay This study demonstrated that circACC1 is upregulated in GC tissues, and its upregulation predicts poorer OS in GC patients. A mechanistic study revealed that the pro-oncogenic effect of circACC1 was mainly caused by binding to miR-29c-3p, thus regulating expression of its downstream target FOXP1. This study demonstrated that circACC1 is upregulated in GC tissues, and its upregulation predicts poorer OS in GC patients. Yes Upregulation of circACC1 promoted GC cell proliferation, as indicated by CCK-8 and colony formation assays. 33887587 hsa_circ_0072309 CircRNA Homo sapiens Stomach Neoplasms GC cell lines Regulation(PI3K/AKT/PPARγ/PTEN signaling pathway) Western Blot//Migration Assay//qRT-PCR//Cell Viability Assay//Colony Formation Assay//Invasion Assay In the present study, hsa_circ_0072309 was downregulated in GC cell lines and its overexpression inhibited the proliferation, migration and invasion of GC cells. In addition, hsa_circ_0072309 overexpression induced activation of the peroxisome proliferator‑activated receptor γ (PPARγ)/PTEN pathway and inhibition of PI3K/AKT signaling. The present findings suggested that hsa_circ_0072309 inhibited proliferation, invasion and migration of gastric cancer cells via the inhibition of PI3K/AKT signaling by activating the PPARγ/PTEN signaling pathway. Yes In the present study, hsa_circ_0072309 was downregulated in GC cell lines and its overexpression inhibited the proliferation, migration and invasion of GC cells. 33760104 hsa_circ_0035445 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues, plasma of gastric cancer patients, and gastric cancer cells Expression(lower expressed) CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Transwell Assay Hsa_circ_0035445 was lowly expressed in gastric cancer tissues, plasma of gastric cancer patients, and gastric cancer cells. The expression level of hsa_circ_0035445 in gastric cancer tissues was relationship with tumor size and distant metastasis. Yes The AUC of hsa_circ_0035445 in tissues and plasma was 0.68 and 0.86, respectively. Upregulation of hsa_circ_0035445 suppressed the proliferation and migration, promoted apoptosis, and blocked cells at G0/G1 phase.Downregulation of hsa_circ_0035445 promoted the proliferation and migration, suppressed apoptosis, and blocked cells at S phase. 33830559 circFAM73A CircRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(miR-490-3p/HMGA2 ) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//FISH//Luciferase Report Assay//Colony Formation Assay//EdU Staining//ChIP Elevated circFAM73A expression was confirmed in GC tissues, and higher circFAM73A predicted poor prognosis in GC patients. Mechanistically, circFAM73A promoted GC malignancy by regulating miR-490-3p/HMGA2 in a positive feedback loop and recruiting HNRNPK to facilitate β-catenin stabilization. Moreover, HMGA2 further enhanced E2F1 and HNRNPL activity, which in turn promoted circFAM73A expression. Yes The upregulation of circFAM73A enhanced CSC-like properties in GC, thus facilitating cell proliferation, migration, and cisplatin resistance. 33731207 circNFATC3 CircRNA Homo sapiens Stomach Neoplasms GC cells Interaction(miR-23b-3p axis ) In Vivo Experiment//IHC//Western Blot//FISH//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay As a consequence, upregulation of RAI14 and circNFATC3 or downregulation of miR-23b-3p was associated with poor prognosis in patients with GC. circNFATC3 had a co-localization with miR-23b-3p in the cytoplasm in GC tissue cells and could act as a sponge of miR-23b-3p in GC cell line. Yes Silencing of circNFATC3 inhibited cell growth and in vivo tumorigenesis by upregulating miR-23b-3p and downregulating RAI14. 33840258 hsa_circ_0043691 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-1294/PBX3 ) Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The levels of hsa_circ_0043691 and PBX3 were upregulated, whereas miR-1294 expression was diminished in GC tissues and cells. Mechanistically, hsa_circ_0043691 was directly bound to miR-1294 to modulate PBX3 expression. Besides, silencing of hsa_circ_0043691 impeded tumor growth in vivo. Yes Hsa_circ_0043691 deficiency significantly inhibited GC cell progression and glutaminolysis metabolism. 36371782 hsa_circ_0001017 CircRNA Homo sapiens Stomach Neoplasms GC cell lines and GC tissues Interaction(miR-197/RHOB signaling pathway) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Decreased hsa_circ_0001017 was discovered in GC, and upregulation of hsa_circ_0001017 notably repressed proliferation, migration, and invasion of GC cell lines. We further certificated that hsa_circ_0001017 served as miR-197 sponge and suppressed the expression of miR-197. Moreover, hsa_circ_0001017 upregulation meaningfully accelerated RHOB expression in both gene and protein levels, and RHOB was a downstream target of miR-197. Yes Decreased hsa_circ_0001017 was discovered in GC, and upregulation of hsa_circ_0001017 notably repressed proliferation, migration, and invasion of GC cell lines. 32740683 hsa_circ_100395 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-142-3p) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay circRNA_100395 expression was found to be increased in GC tissues and cell lines. However, miR-142-3p expression was significantly reduced. cirRNA_100395-overexpression had antitumor effects via regulating the miR-142-3p signaling pathway. Besides, low expression levels of circRNA_100395 were associated with poor tumor differentiation, advanced Tumor-Node-Metastasis stage, lymph node metastasis and shorter overall survival time. Yes Moreover, overexpression of circRNA_100395 suppressed cell proliferation, increased the apoptosis rate and suppressed cell invasion and migration by inhibiting the PI3K/AKT signaling pathway. 33841580 hsa_circ_0004104 CircRNA Homo sapiens Stomach Neoplasms GEO ( three paired GC tissues and normal samples in GSE141977) Interaction(miR-539-3p/RNF2 Axis) In Vivo Experiment//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Circ_0004104 was upregulated in GC, and its knockdown repressed the proliferation, metastasis, and glutaminolysis of GC cells in vitro and reduced GC tumor growth in vivo. Furthermore, we discovered that circ_0004104 could sponge miR-539-3p and miR-539-3p could target RNF2. Yes Circ_0004104 was upregulated in GC, and its knockdown repressed the proliferation, metastasis, and glutaminolysis of GC cells in vitro and reduced GC tumor growth in vivo. 33449226 circCOL1A1 CircRNA Homo sapiens Stomach Neoplasms gastric cancer cells and tissues Interaction(miR-145) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Invasion Assay The results showed that circCOL1A1 was highly expressed in both gastric cancer cells and tissues. circCOL1A1 regulated the expression of miR-145 by acting as a microRNA sponge, and the influence of circCOL1A1 could be abrogated by miR-145 mimics. Yes Silence of circCOL1A1 inhibited the proliferation, migration, and invasion of gastric cancer cells. 34631898 circDONSON CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-149-5p/LDHA Axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our results suggested that circ-DONSON was highly expressed in GC tissues and cells. In terms of mechanism, circ-DONSON could sponge miR-149-5p, which could target LDHA in GC. Yes Loss-functional assay results confirmed that silenced circ-DONSON could inhibit the proliferation, metastasis and angiogenesis, while enhance the apoptosis and radiosensitivity of GC cells. 34409524 circPGPEP1 CircRNA Homo sapiens Stomach Neoplasms 51 paired GC tissues and adjacent normal tissues Interaction(miR-1297 ) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_PGPEP1 was a highly expressed circRNA in GC.MiR-1297 could be sponged by circ_PGPEP1, and its expression was downregulated in GC. Yes Loss-of-function experiment indicated that circ_PGPEP1 silencing could induce cell cycle arrest and apoptosis, while inhibit proliferation, migration, and invasion in GC cells. 33386518 hsa_circ_0044366 CircRNA Homo sapiens Stomach Neoplasms The whole blood samples of GC Interaction(miR-29a) CCK8//qRT-PCR//In Vivo Experiment//Migration Assay We detected that exosomal circ29 was confirmed to be highly expressed in GC and can significantly impair the proliferation, migration, tube formation of HUVEC by exosomal communication. Interestingly, this effect could be blocked by the effect of miR-29a. Yes We detected that exosomal circ29 was confirmed to be highly expressed in GC and can significantly impair the proliferation, migration, tube formation of HUVEC by exosomal communication. 33965787 hsa_circ_0000117 CircRNA Homo sapiens Stomach Neoplasms GC cells Interaction(microRNA-337-3p/signal transducer and activator of transcription 3 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay In the present study, we observed increased hsa_circ_0000117 and signal transducer and activator of transcription 3 (STAT3) expression, while microRNA-337-3p (miR-337-3p) was decreased in GC cells. Hsa_circ_0000117 was also identified as a miR-337-3p sponge.  Yes Depleted hsa_circ_0000117 decreased GC proliferation and invasion. 33896365 circDIDO1 CircRNA Homo sapiens Stomach Neoplasms 102 paired GC and adjacent non-cancerous tissues Interaction(PRDX2) Co-IP//RIP//RNA-seq//In Vivo Experiment circDIDO1 was down-regulated in GC tissues and its low levels were associated with larger tumor size, distal metastasis, and poor prognosis.Mechanistically, circDIDO1 encoded a novel 529aa protein that directly interacted with poly ADP-ribose polymerase 1 (PARP1) and inhibited its activity. CircDIDO1 also specifically bound to peroxiredoxin 2 (PRDX2) and promoted RBX1-mediated ubiquitination and degradation of PRDX2, which led to the inactivation of its downstream signaling pathways. circDIDO1 was down-regulated in GC tissues and its low levels were associated with larger tumor size, distal metastasis, and poor prognosis. Yes CircDIDO1 overexpression inhibited while knockdown promoted GC cell proliferation, migration and invasion. CircDIDO1 overexpression suppressed GC growth and metastasis in mouse tumor models. 34384442 circDLG1 CircRNA Homo sapiens Stomach Neoplasms distant metastatic lesions and gastric cancer tissues resistant to anti-PD-1 therapy Interaction(miR-141-3p) In Vivo Experiment//Western Blot//ISH//Colony Formation Assay//Flow Cytometry//qRT-PCR//FISH//CCK8//Migration Assay//RIP//Luciferase Report Assay//Microarray//RNA-seq//IHC//Invasion Assay circDLG1 was significantly upregulated in distant metastatic lesions and gastric cancer tissues resistant to anti-PD-1 therapy and was associated with an aggressive tumor phenotype and adverse prognosis in gastric cancer patients treated with anti-PD-1 therapy. Mechanistically, circDLG1 interacted with miR-141-3p and acted as a miRNA sponge to increase the expression of CXCL12, which promoted gastric cancer progression and resistance to anti-PD-1-based therapy. circDLG1 was significantly upregulated in distant metastatic lesions and gastric cancer tissues resistant to anti-PD-1 therapy and was associated with an aggressive tumor phenotype and adverse prognosis in gastric cancer patients treated with anti-PD-1 therapy. Yes Ectopic circDLG1 expression promoted the proliferation, migration, invasion, and immune evasion of gastric cancer cells. 34911533 circHN1 CircRNA Homo sapiens Stomach Neoplasms GEO (gastric cancer) Interaction(miR-628-5p/Ecto-5'-nucleotidase competing endogenous RNA network) In Vivo Experiment//RNA Pull-Down//Western Blot//Invasion Assay//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis Our data showed that circ_HN1 expression was enhanced in human gastric cancer. NT5E was a downstream effector of circ_HN1 function. NT5E was targeted and inhibited by miR-628-5p through the perfect complementary site in NT5E 3'UTR, and circ_HN1 affected NT5E expression through miR-628-5p competition. Yes Depletion of circ_HN1 impeded cell proliferation, spheroid formation, invasion, and migration and promoted apoptosis in vitro, as well as diminished tumor growth in vivo. 34637682 circMAPK1 CircRNA Homo sapiens Stomach Neoplasms 80 paired human GC and adjacent non-tumor tissues Interaction(MAPK1-109aa) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//IF//Luciferase Report Assay//PCR//Colony Formation Assay//EdU Staining//Transwell Assay In this study, we identified that circMAPK1 (hsa_circ_0004872) was downregulated in gastric cancer tissues compared with adjacent normal tissues. Our study revealed that circMAPK1 inhibits the malignant biological behavior of gastric cancer cells through its encoded protein MAPK1-109aa. Importantly, lower circMAPK1 expression predicted poor survival in GC patients. Yes CircMAPK1 inhibited the proliferation and invasion of gastric cancer cells in vitro and in vivo. 33836754 hsa_circ_002059 CircRNA Homo sapiens Stomach Neoplasms Human GC cell lines Interaction(miR-182/MTSS1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay MTSS1 was found to be a direct target of miR-182 and circ_002059 upregulated MTSS1 expression by competitively sponging miR-182. Yes Overexpression of circ_002059 significantly inhibited, whereas knockdown of circ_002059 notably facilitated, cell proliferation and migration in GC cells. Circ_002059 inhibited GC cell xenograft tumor growth by regulating miR-182 and MTSS1 expression. 33686422 circLMO7 CircRNA Homo sapiens Stomach Neoplasms Clinical tissue specimens Interaction(miR-30a-3p/WNT2/β-Catenin pathway) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Wound Healing Assay//qRT-PCR//FISH//IF//RIP//Luciferase Report Assay//H&E Staining//Colony Formation Assay//EdU Staining//Transwell Assay CircLMO7 acted as a miR-30a-3p sponge affecting the WNT2/β-Catenin pathway to promote the proliferation, migration and invasion of GC cells. Yes CircLMO7 acted as a miR-30a-3p sponge affecting the WNT2/β-Catenin pathway to promote the proliferation, migration and invasion of GC cells. Moreover, animal results also showed that circLMO7 could promote GC growth and metastasis in vivo. 33397440 circATP2B1 CircRNA Homo sapiens Stomach Neoplasms Normal gastric tissues (GT), highly differentiated gastric adenocarcinoma cancer specimens (HDAC) and poorly differentiated gastric adenocarcinoma cancer specimens (PDAC) Interaction(miR-326) In Vivo Experiment//Western Blot//ISH//qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay Our data showed that circRNA circATP2B1 (also called hsa_circ_000826) was overexpressed in gastric cancer tissues instead of linear ATP2B1 mRNA, and it promoted aerobic glycolysis in gastric cancer cells. Bioinformatic Gene Ontology analysis showed that the potential downstream targets of circATP2B1 include the microRNA miR-326 gene cluster (miR-326-3p/miR-330-5p), which is functionally focused on cell growth and metabolic processes. Yes Taken together, circATP2B1 captured miR-326-3p/miR-330-5p and decreased the suppression of PKM2 by miR-326-3p/miR-330-5p, thus aiding the aerobic glycolysis and proliferation of gastric cancer cells. 33996547 circCORO1C CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-138-5p/KLF12 Axis) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_CORO1C and KLF12 were upregulated, while miR-138-5p was downregulated in GC tissues and cells. Circ_CORO1C targeted miR-138-5p, the inhibition of which could attenuate silenced circ_CORO1C-induced inhibitory effects on GC progression. MiR-138-5p repressed the aggressive malignant behaviors of GC cells by directly targeting KLF12. Yes Circ_CORO1C knockdown suppressed colony formation ability, viability, migration, invasion and EMT in GC cells, while promoted cell apoptosis in vitro. Circ_CORO1C deficiency inhibited GC tumor growth in vivo. 34007212 circDNA2 CircRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(miR-149-5p/CCDC6 axis) RNA Pull-Down//Western Blot//ISH//CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Colony Formation Assay//EdU Staining By performing quantitative real-time PCR and fluorescence in situ hybridization (FISH) assays with a human tissue microarray, circDNA2 was found to be highly expressed in GC tissues and associated with lymphatic invasion of GC patients. Mechanistically, circDNA2 acted as a microRNA (miR)-149-5p sponge, which was confirmed to target CCDC6 by RNA pulldown and dual-luciferase reporter assays and rescue experiments. Both low miR-149-5p expression and high CCDC6 expression were related to unfavorable prognosis in GC patients. Yes Knockdown of circDNA2 expression suppressed the proliferation of GC cells by reducing CCDC6 expression. 34552818 circNEK9 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-409-3p/MAP7 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//Invasion Assay//Transwell Assay CircNEK9 was up-regulated in GC tissues and cell lines. CircNEK9 accelerated the proliferation, migration, and invasion of GC cells through targeting miR-409-3p/MAP7 axis. Plasma exosomal circNEK9 promoted the migration and invasion of recipient GC cells. Yes CircNEK9 interference suppressed the proliferation and motility of GC cells. CircNEK9 silencing enhanced microRNA-409-3p (miR-409-3p) level through direct interaction. CircNEK9 silencing-mediated influences on the proliferation and metastasis of GC cells were partly overturned by the interference of miR-409-3p. 33449227 hsa_circ_0006470 CircRNA Homo sapiens Stomach Neoplasms GC cells Interaction(miR-27b-3p) Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay The results showed that hsa_circ_0006470 expression was significantly elevated in GC cells, which was mainly distributed in cytoplasmic components and could directly bind with miR-27b-3p in GC cells. Yes Silencing of hsa_circ_0006470 repressed cell proliferation, migration, and invasion, which may be through regulating miR-27b-3p/Receptor tyrosine kinase-like orphan receptor 1 (ROR1). Silencing of hsa_circ_0006470 also elevated LC3II and Beclin-1 and suppressed p62 protein abundances, which subsequently induced autophagy in AGS cells. 34641696 hsa_circ_0043691 CircRNA Homo sapiens Stomach Neoplasms GC tissue and cells Interaction(miR-873-3p-GART axis) Western Blot//Bioinformatics Analysis//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay CircRNA_0043691 was upregulated in GC tissue. CircRNA_0043691 has potential putative binding sites with miR-873-3p. Moreover, CircRNA_0043691 positively regulated GART expression by sponging miR-873-3p. Yes Knockdown of circRNA_0043691 decreased cell viability, migration, and invasion in GC cells. 34370061 circALPL CircRNA Homo sapiens Stomach Neoplasms gastric cancer cell Interaction(miR-127-MTDH pathway) In Vivo Experiment//Western Blot//CCK8//RIP//qRT-PCR//Luciferase Report Assay//Transwell Assay circALPL downregulation suppresses the invasion and proliferation ability of gastric cancer cells. The results showed that circALPL promotes gastric cancer progression by sponging miR-127, thus upregulating MTDH. Yes circALPL downregulation suppresses the invasion and proliferation ability of gastric cancer cells. 34234862 circPTPN22 CircRNA Homo sapiens Stomach Neoplasms GC tissues, cells, and plasma Expression(highly expressed) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//circRNA-seq//Colony Formation Assay//Transwell Assay CircPTPN22 is up-regulated and positively correlated with metastasis in GC tissues, cells, and plasma. RT-qPCR results showed that circPTPN22 had good diagnostic efficacy and could be used to predict the prognosis of GC patients. Yes In vitro and vivo experiments showed that the downregulation of circPTPN22 could inhibit cell proliferation, migration, and invasion through the epithelial-mesenchymal transformation (EMT) pathway. 33430866 hsa_circ_0049447 CircRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(miR-324-5p) In Vivo Experiment//IHC//Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay We demonstrated that circ_0049447 was downregulated in GC (P < 0.001). Upregulation of miR-324-5p in GC specimens and direct binding between miR-324-5p with circ_0049447 proven by luciferase reporter assay indicated that circ_0049447 may inhibit GC by sponging certain miRNA. Yes CCK-8 and colony formation assay showed that overexpression of circ_0049447 could inhibit the proliferation (P < 0.05). Transwell migration and invasion assay showed upregulated circ_0049447 could impede migration in GC cells (P < 0.05). In addition, overexpression of circ_0049447 could impede GC cell EMT. 33883408 hsa_circ_0000064 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-621/SYF2 axis) RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//BrdU//IHC//Transwell Assay Cric_0000064 expression was elevated in GC tissues and cell lines. Circ_0000064 can participate in the GC progression via modulating miR-621/SYF2 axis. Yes Knocking down cric_0000064 could inhibit the viability, migration, and invasion of GC cells. 34245111 hsa_circ_0002360 CircRNA Homo sapiens Stomach Neoplasms GC cells Interaction( miR-629-3p/PDLIM4 ) Western Blot//qRT-PCR//ELISA//Colony Formation Assay//Invasion Assay//Transwell Assay Circ0002360 was found to be upregulated in GC cells using QRT-PCR.Furthermore, miR-629-3p, a target miRNA of circ0002360, was the most suppressed miRNA following circ0002360 overexpression. RNA immunoprecipitation (RIP), dual-luciferase reporter analyses, clone formation, transwell, DCFH-DA, and ELISA assays demonstrated that circ0002360-targeted miR-629-3p promotes cell proliferation and migration while inhibiting oxidative stress. randomForest analysis indicated that PDLIM4 was the target gene of miR-629-3p, whose level was increased by circ0002360 but reversed by miR-629-3p mimics. Yes RNA immunoprecipitation (RIP), dual-luciferase reporter analyses, clone formation, transwell, DCFH-DA, and ELISA assays demonstrated that circ0002360-targeted miR-629-3p promotes cell proliferation and migration while inhibiting oxidative stress. 35982735 circPRRX1 CircRNA Homo sapiens Stomach Neoplasms gastric cancer cells Interaction(circPRRX1/miR-596/ NKAP) Migration Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay Our data showed that circPRRX1 expression was elevated in human gastric cancer, and circPRRX1 could be transferred by exosomes from gastric cancer cells. Mechanistically, circPRRX1 directly regulated miR-596 expression, and exosomal circPRRX1 affected cell biological functions at least in part through miR-596. NKAP was identified as a direct target and functionally downstream effector of miR-596. Yes Exosomal circPRRX1 affected cell proliferation, motility, invasion, and radiation sensitivity in vitro and tumor growth in vivo . 36206097 hsa_circ_0006089 CircRNA Homo sapiens Stomach Neoplasms GC samples and cell lines Interaction(miR-143-3p/IGF1R axis) Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay//BrdU//Bioinformatics Analysis//Transwell Assay Circ_0006089 expression was up-regulated in GC samples and cell lines. Additionally, miR-143-3p was validated as a downstream target of circ_0006089, and circ_0006089 could positively regulate IGF1R expression via repressing miR-143-3p. Circ_0006089 is highly expressed in GC, and it promotes the malignancy of GC cells via modulating miR-143-3p/IGF1R axis, suggesting that circ_0006089 may serve as a promising therapeutic target for GC. And high circ_0006089 expression was associated with shorter survival time in GC patients. Yes Circ_0006089 overexpression in GC cells significantly accelerated GC cell proliferation, migration and invasion, whereas circ_0006089 knockdown resulted in the opposite effects. 35545863 circRELL1 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(circRELL1/miR-637/EPHB3 axis ) RNA Pull-Down//IHC//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Herein, we discover circRNA RELL1, which has not been investigated in GC, and it is markedly downregulated in GC tissues, which is related with poor prognosis, more pronounced lymph node metastasis and poor TNM stage.Further mechanism investigation demonstrated that circRELL1 could sponge miR-637 and indirectly unregulated the expression of EPHB3 via modulating autophagy activation in GC. Additionally, circRELL1 can be transmitted by exosomal communication, and exosomal circRELL1 suppressed the malignant behavior of GC in vivo and in vitro. Herein, we discover circRNA RELL1, which has not been investigated in GC, and it is markedly downregulated in GC tissues, which is related with poor prognosis, more pronounced lymph node metastasis and poor TNM stage. Yes After confirming the circular structure of circRELL1, we found that circRELL1 could block cell proliferation, invasion, migration, and anti-apoptosis in patients with GC by a series of in vivo and in vitro function-related studies. 35027539 circTHBS1 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-204-5p/INHBA) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//IHC//Transwell Assay The expression of circTHBS1 was significantly increased in GC and associated with poor prognosis. Mechanistically, circTHBS1 sponged miR-204-5p to promote the expression of Inhibin Subunit Beta A (INHBA). Moreover, circTHBS1 could enhance the HuR-mediated mRNA stability of INHBA, which subsequently activated the TGF-β pathway. The expression of circTHBS1 was significantly increased in GC and associated with poor prognosis. Yes CircTHBS1 facilitated the malignant behavior and epithelial-to-mesenchymal transition of GC cells. 35338119 circCEA CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(p53/CDK1) RNA Pull-Down//Western Blot//Tunel//qRT-PCR//FISH//IHC//IF Circ_CEA is significantly upregulated in GC tissues and cell lines.Mechanistically, circ_CEA interacts with p53 and cyclin-dependent kinases 1 (CDK1) proteins. It serves as a scaffold to enhance the association between p53 and CDK1. As a result, circ_CEA promotes CDK1-mediated p53 phosphorylation at Ser315, then decreases p53 nuclear retention and suppresses its activity, leading to the downregulation of p53 target genes associated with apoptosis. These findings suggest that circ_CEA protects GC cells from stress-induced apoptosis, via acting as a protein scaffold and interacting with p53 and CDK1 proteins. Yes Circ_CEA knockdown suppresses GC progression, and enhances stress-induced apoptosis in vitro and in vivo. 36167685 circARID1A CircRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(circARID1A-IGF2BP3-SLC7A5) RNA Pull-Down//Western Blot//CCK8//RIP//FISH//qRT-PCR//EdU Staining We identified a novel circRNA, circARID1A, that can bind to IGF2BP3 protein. CircARID1A was significantly upregulated in GC tissues compared with noncancerous tissues and positively correlated with tumor length, tumor volume, and TNM stage. Mechanistically, circARID1A served as a scaffold to facilitate the interaction between IGF2BP3 and SLC7A5 mRNA, finally increasing SLC7A5 mRNA stability. Additionally, circARID1A was able to directly bind SLC7A5 mRNA through complementary base-pairing and then formed the circARID1A-IGF2BP3-SLC7A5 RNA-protein ternary complex and promoted the proliferation of GC via regulating AKT/mTOR pathway. CircARID1A was significantly upregulated in GC tissues compared with noncancerous tissues and positively correlated with tumor length, tumor volume, and TNM stage. Yes CircARID1A knockdown inhibited the proliferation of GC cells in vitro and in vivo and circARID1A played an important role in the oncogenic function of IGF2BP3. 35986300 hsa_circ_0000437 CircRNA Homo sapiens Stomach Neoplasms GC cell Regulation( Ser/Arg-rich splicing factor 3) FISH Hsa_circ_0000437 regulated GC cell proliferation, invasion, migration and apoptosis by targeting Ser/Arg-rich splicing factor 3 (SRSF3) and inhibiting programmed cell death 4 (PDCD4). Yes The ectopic expression of hsa_circ_0000437 dramatically promoted tumor growth in nude mice in vivo. 36109630 circZNF131 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-186-5p/PFKFB2 Axis) IHC//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay Expression analysis indicated that circZNF131 was upregulated in GC tissues and cells in a stable structure.Mechanically, miR-186-5p was a target of circZNF131, and miR-186-5p could bind to PFKFB2. Rescue experiments presented that miR-186-5p inhibition reversed the effects of circZNF131 knockdown on GC cell growth and glycolysis, and PFKFB2 overexpression abolished the impacts of miR-186-5p restoration on GC cell progression. Moreover, circZNF131 could positively modulate PFKFB2 expression via sponging miR-186-5p. Yes Functional analyses showed that circZNF131 knockdown suppressed GC cell colony formation ability, migration, invasion and glycolysis metabolism, and induced cell apoptosis.In vivo, circZNF131 knockdown hindered GC tumor growth by regulating the miR-186-5p/PFKFB2 axis. 35059934 hsa_circ_0000654 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction( miR-149-5p/INHBA) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay circ_0000654 and INHBA were up-regulated but miR-149-5p was down-regulated in GC.circ_0000654 absorbed miR-149-5p to target INHBA.circ_0000654 silence or miR-149-5p overexpression limited the growth of GC tumors in vivo. Obviously, circ_0000654 facilitates the growth of GC cells through absorbing miR-149-5p to up-regulate INHBA. Yes Silencing circ_0000654inhibited the progress of GC cell biology. Oppositely, restoring circ_0000654 enhanced the growth of GC cells. Inhibiting miR-149-5p rescued down-regulated circ_0000654-induced anti-tumor effect on GC. 35100076 circPDIA4 CircRNA Homo sapiens Stomach Neoplasms tissues Interaction(DHX9) RNA Pull-Down//Western Blot//Wound Healing Assay//Co-IP//CCK8//qRT-PCR//RIP//IF//Luciferase Report Assay//RNA-seq//Colony Formation Assay//Transwell Assay Clinically, circPDIA4 was significantly upregulated in malignant tissues and was associated with poor survival of patients with gastric cancer. In the nucleus, circPDIA4 interacted with DHX9 as a decoy and repressed its inhibitory functions on circRNA biogenesis to boost expression of multiple oncogenic circRNAs, which promoted gastric cancer progression. Clinically, circPDIA4 was significantly upregulated in malignant tissues and was associated with poor survival of patients with gastric cancer. Yes Elevated expression of circPDIA4 promoted distant metastasis in various mouse xenograft models in vivo and accelerated cancer cell invasion in vitro. 36562654 circHN1 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-485-5p/GSK3A pathway) CCK8//qRT-PCR//RNA Pull-Down//Luciferase Report Assay In both GC tissues and cells, circ-HN1 expression was upregulated, and its silencing suppressed cellular processes. Moreover, circ-HN1 served as a sponge of miR-485-5p, which was reduced in patients with GC and negatively regulated by circ-HN1 in GC cells. Inhibition of miR-485-4p abolished the biological functions induced by the silencing of circ-HN1. Additionally, miR-485-5p targeted GSK3A in GC, whose expression was elevated in tumor tissues and was negatively correlated with miR-485-5p in tumor cells. GSK3A rescued the inhibition of miR-485-5p in the cellular processes. Yes In both GC tissues and cells, circ-HN1 expression was upregulated, and its silencing suppressed cellular processes. 34607506 hsa_circ_0061276 CircRNA Homo sapiens Stomach Neoplasms plasma Interaction(hsa-miR-7705) Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//Transwell Assay The results show that plasma hsa_circ_0061276 copy number showed a trend of a gradual decrease when comparing healthy controls to the early cancer group and advanced gastric cancer group.Through bioinformatic analyses combined with cellular experiments, it was found that hsa_circ_0061276 inhibited the growth of gastric cancer by binding to hsa-miR-7705. Yes Overexpression of hsa_circ_0061276 inhibited the growth and migration of gastric cancer cells. 36620570 circBGN CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(IL6/STAT3 signaling pathway) Western Blot//Migration Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Our results showed that circBGN expression was significantly elevated in GC tissues and cells. Furthermore, circBGN can directly bind to miR-149-5p, thereby preventing miR-149-5p from binding to its target mRNA [IL6 mRNA], thus activating IL6/STAT3 signaling pathway. Rescue assays indicated that circBGN regulates GC cell proliferation and invasion by upregulating miR-149-5p/IL6 axis output. Yes Knockdown of circBGN dramatically suppressed GC cell proliferation and invasion in vitro. Xenograft experiments revealed that knockdown of circBGN delayed tumor growth in vivo. 36250950 hsa_circ_0091741 CircRNA Homo sapiens Stomach Neoplasms GC cells and their exosomes Interaction(miR-330-3p/TRIM14/Dvl2/Wnt/β-catenin axis) Tunel//CCK8//RIP//Luciferase Report Assay//CO-IP GC cells and their exosomes were characterized by upregulated circ_0091741 expression.circ_0091741 obstructed the binding of miR-330-3p to TRIM14 and increased the expression of TRIM14. TRIM14 could cause activation of the Wnt/β-catenin signaling pathway by stabilizing Dvl2. Yes circ_0091741 transferred by GC cell-derived exosomes induced the autophagy and OXA resistance of GC cells. 36323918 hsa_circ_0000592 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(MiR-1179 was a direct target of circ_0000592, and circ_0000592 silencing-mediated effects in GC cells were partly reversed by the knockdown of miR-1179. MiR-1179 interacted with the 3' untranslated region (3'UTR) of ANXA4. Circ_0000592 silencing reduced ANXA4 expression partly by upregulating miR-1179 in GC cells. ANXA4 overexpression partly overturned circ_0000592 knockdown-induced effects in GC cells.) RNA Pull-Down//Western Blot//Bioinformatics Analysis//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay Circ_0000592 expression was elevated in GC tissues and cells. MiR-1179 was a direct target of circ_0000592, and circ_0000592 silencing-mediated effects in GC cells were partly reversed by the knockdown of miR-1179. MiR-1179 interacted with the 3' untranslated region (3'UTR) of ANXA4. Circ_0000592 silencing reduced ANXA4 expression partly by upregulating miR-1179 in GC cells. ANXA4 overexpression partly overturned circ_0000592 knockdown-induced effects in GC cells. Yes Circ_0000592 knockdown hampered cell proliferation, migration, invasion and glycolysis of GC cells. 34459457 hsa-circ-0052001 CircRNA Homo sapiens Stomach Neoplasms GC cells and tissues. Regulation(MAPK ) Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay We found that compared with normal gastric mucosa epithelial cells and adjacent paracancer tissues, hsa-circ-0052001 was overexpressed in GC cells and tissues. Mechanistically, hsa-circ-0052001 promoted the carcinogenesis of GC cells via the MAPK signal pathway. Also, the hsa-circ-0052001 level was linked to patient clinicopathological characteristics of GC. Yes Cell proliferation and metastatic ability were inhibited in gastric cancer cells when hsa-circ-0052001 was knocked down in vitro and cancer growth in vivo. 36453441 hsa_circ_0001013 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-136/TWSG1 ) Northern Blot//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//FISH//EdU Staining//Transwell Assay Circ_0001013 was predicted to be up-regulated in GC by microarray profiling, which was confirmed by RT-qPCR detection in GC tissues and cells. miR-136 was poorly expressed, and TWSG1 was highly expressed in GC tissues. Mechanistically, circ_0001013 bound to miR-136, which negatively targeted TWSG1 in the GC cells. Yes Silencing circ_0001013 or TWSG1 or over-expressing miR-136 led to decreased GC cell proliferation, migration, invasion, and cell cycle arrest and enhanced apoptosis. Furthermore, silencing circ_0001013 resulted in diminished TWSG1 expression and inhibited transplanted tumor growth in the nude mice. 35958507 hsa_circ_0006089 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-143-3p/PTBP3 axis and PI3K/AKT signaling pathway) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay Circ_0006089 expression was increased in GC. MiR-143-3p specially bound to circ_0006089 and PTBP3 was targeted by miR-143-3p. Moreover, circ_0006089 could regulate PTBP3 expression and the PI3K/AKT pathway by sponging miR-143-3p. Circ_0006089 knockdown also suppressed tumor growth. Yes Circ_0006089 downregulation suppressed the proliferation and metastasis and induced apoptosis of GC cells, which was counteracted by miR-143-3p inhibition or PTBP3 overexpression. In addition, circ_0006089 overexpression could promote GC progression. 35844201 circPCSK5 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Expression(highly expressed) Other The expression of circPCSK5 was significantly upregulated in GC tissues and cells (P < 0.001, P < 0.01). The expression level of circPCSK5 was positively correlated with tumor size, vascular invasion, lymph node metastasis and AJCC stage of GC (P < 0.05). The overall survival and disease-free survival were significantly lower in GC patients with high circPCSK5 expression than in those with low circPCSK5 expression (P < 0.001). Yes Knockdown of circPCSK5 significantly inhibited the proliferation, migration and invasion of HGC27 cells (P < 0.01), increased the expressions of E-cadherin, and decreased the expression of N-cadherin and vimentin (P < 0.01). CircPCSK5 overexpression promoted the proliferation, migration and invasion of MKN45 cells (P < 0.01), reduced E-cadherin expression and increased N-cadherin and vimentin expressions (P < 0.01). 36329577 hsa_circ_0005529 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction(miR-873-5p/ZEB1 ) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay hsa_circ_0005529 was strongly expressed in gastric cancer where it stimulated tumorigenic behavior. Furthermore, hsa_circ_0005529 was shown to promote ZEB1 expression by sponging miR-873-5p, an inhibitor of ZEB1 expression. Yes hsa_circ_0005529 was strongly expressed in gastric cancer where it stimulated tumorigenic behavior. 36305048 hsa_circ_0006089 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells, Interaction(miR-361-3p/TGFB1) IHC//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//ELISA//Colony Formation Assay circ_0006089 had been found to be upregulated in GC tissues and cells, and it could act as an miR-361-3p sponge. TGFB1 was targeted by miR-361-3p, and its overexpression reversed the effects of miR-361-3p on GC cell function. Also, circ_0006089 promoted TGFB1 expression via sponging miR-361-3p. Yes circ_0006089 knockdown suppressed GC proliferation, metastasis, glycolysis, angiogenesis, and increased apoptosis, while this effect could be revoked by miR-361-3p inhibitor. Animal experiments showed that silenced circ_0006089 inhibited GC tumorigenesis through the miR-361-3p/TGFB1 pathway. 35347818 hsa_circ_0026344 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-590-5p/PDCD4 axis) Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay//Transwell Assay Circ_0026344 expression was underexpressed in GC tissues and cells, which was associated with clinicopathological characteristics such as tumour size, tumor-node-metastasis stage and lymph node metastasis.Circ_0026344 could act as a competing endogenous RNA of miR-590-5p to negatively modulate its expression, and this miRNA could mitigate the impact of circ_0026344 on GC cells. In addition, PDCD4 was identified as the downstream target of miR-590-5p, and PDCD4 expression was positively modulated by circ_0026344. Circ_0026344 expression was underexpressed in GC tissues and cells, which was associated with clinicopathological characteristics such as tumour size, tumor-node-metastasis stage and lymph node metastasis. Yes Circ_0026344 overexpression restrained the malignant biological behaviours of GC cells, while circ_0026344 knockdown functioned oppositely. 35640631 circEVI5 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction( miR-4793-3p/FOXO1) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Cell Cycle Assay//EdU Staining circEVI5 was significantly downregulated in GC tissues and cells, and low circEVI5 expression was correlated with poor prognosis. Moreover, bioinformatics prediction showed that circEVI5 binds to miR-4793-3p, while FOXO1 may be a target of miR-4793-3p. Pull-down assays, RNA immunoprecipitation (RIP) assays, luciferase assays, and western blot were used to confirm the interactions between circEVI5, miR-4793-3p, and FOXO1. circEVI5 was significantly downregulated in GC tissues and cells, and low circEVI5 expression was correlated with poor prognosis. Yes Gain of function experiments indicated that circEVI5 could inhibit GC cell proliferation and retard the cell cycle. 34354043 hsa_circ_001988 CircRNA Homo sapiens Stomach Neoplasms 341 GC patients Interaction(miR-197-3p/FBXW7 ) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Wound Healing Assay//Migration Assay//qRT-PCR//RIP//Cell Viability Assay//Cell Cycle Assay//Colony Formation Assay//Invasion Assay//Transwell Assay We first found that the expression of hsa_circ_001988 was decreased in 341 GC patients that was related to World Health Organization histological types, Lauren types, and tumor invasion depth (p < .05). Mechanistically, hsa_circ_001988 attenuated the miR-197-3p expression possibly due to its molecular sponge effect, and then, positively promoted FBXW7 expression. We first found that the expression of hsa_circ_001988 was decreased in 341 GC patients that was related to World Health Organization histological types, Lauren types, and tumor invasion depth (p < .05). Yes Silencing of hsa_circ_001988 facilitated proliferation, colony formation, migration, and invasion of GC cells, while overexpression of hsa_circ_001988 reversed the effect on GC progression in vitro. Additionally, the results of subcutaneous xenotransplanted tumor model demonstrated that overexpressing hsa_circ_001988 significantly suppressed the subcutaneous tumor growth in vivo. 32592202 hsa_circ_0000144 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(MiR-217) RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The circ_0000144 expression was obviously upregulated in GC tissues and cells. Moreover, circ_0000144 sponged miR-217, and rescue assays revealed that silencing miR-217 expression reversed the inhibitory effect of circ_0000144 knockdown on the progress of GC. Yes Silencing of circ_0000144 inhibited cell proliferation, migration and invasion of GC cells, but ectopic expression of circ_0000144 showed the opposite results. 33958507 hsa_circ_0006282 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-144-5p/YWHAB axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0006282 level was increased in GC tissues and cells compared to normal tissues and cells. For mechanism analysis, circ_0006282 was identified to function as the sponge for miR-144-5p to positively regulate YWHAB expression in GC cells. Moreover, miR-144-5p inhibition or YWHAB overexpression effectively reversed the impacts of circ_0006282 knockdown on GC cell growth and motility. Yes Silencing of circ_0006282 restrained GC cell proliferation, migration and invasion. Additionally, circ_0006282 knockdown blocked tumor growth of GC in vivo. 33536789 hsa_circ_0027599 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-21-5p/RUNX1 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//H&E Staining//Colony Formation Assay//Transwell Assay Circ_0027599 and RUNX1 were downregulated in GC tissues and cells.For mechanism analysis, circ_0027599 positively regulated RUNX1 expression via functioning as the sponge for miR-21-5p. RUNX1 inhibition reversed circ_0027599 overexpression mediated malignant behaviours of GC cells. Circ_0027599 level was associated with the overall survival of GC patients. Yes Circ_0027599 or RUNX1 overexpression inhibited GC cell viability, colony formation, migration, invasion and cell cycle process in vitro. Moreover, circ_0027599 overexpression repressed tumour growth in vivo. 34032284 hsa_circ_0008434 CircRNA Homo sapiens Stomach Neoplasms GC tissue Interaction(miR-6838-5p) Western Blot//Wound Healing Assay//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC//Transwell Assay We found that hsa_circ_0008434 was one of the most upregulated circRNAs in GC tissue versus normal tissue. Further in vitro testing indicated that by acting as a miRNA sponge for miR-6838-5p, hsa_circ_0008434 promotes the expression of USP9X and further increases the proliferation, migration, and invasion of GC cells. In addition, animal studies indicated that hsa_circ_0008434 could promote tumour growth in vivo. Yes Further in vitro testing indicated that by acting as a miRNA sponge for miR-6838-5p, hsa_circ_0008434 promotes the expression of USP9X and further increases the proliferation, migration, and invasion of GC cells. In addition, animal studies indicated that hsa_circ_0008434 could promote tumour growth in vivo. 34856948 circPRKDC CircRNA Homo sapiens Stomach Neoplasms GC samples and cells Interaction(miR-493-5p/IRS2) IHC//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircPRKDC was upregulated in GC samples, and circPRKDC silencing restrained GC cell viability, metastasis, and EMT and suppressed GC tumor growth. Besides, miR-493-5p was a target of circPRKDC, and the repressive impact of circPRKDC knockdown on GC development was neutralized by miR-493-5p inhibition. Moreover, miR-493-5p targeted IRS2 and IRS2 addition rescued the effects of circPRKDC depletion on GC progression. Finally, circPRKDC knockdown could regulate IRS2 expression by targeting miR-493-5p. Yes CircPRKDC was upregulated in GC samples, and circPRKDC silencing restrained GC cell viability, metastasis, and EMT and suppressed GC tumor growth. 34605348 circSMAD4 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(CTNNB1/wnt/β-catenin pathway) RNA Pull-Down//IHC//Western Blot//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Microarray//Colony Formation Assay//EdU Staining//ChIP Circ_SMAD4 expression was potentiated in GC. Mechanically, nuclear circ_SMAD4 recruited TCF4 to facilitate CTNNB1 transcription, while cytoplasmic circ_SMAD4 sequestered miR-1276 to prevent the silence of CTNNB1 mRNA, leading to activation of Wnt/β-catenin pathway. Yes Circ_SMAD4 depletion impeded GC cell growth in vitro and restrained tumorigenesis in vivo. 33458917 hsa_circ_0051620 CircRNA Homo sapiens Stomach Neoplasms tumoral tissues and cell lines Interaction(miR-338-3p/ADAM17) Western Blot//Migration Assay//CCK8//qRT-PCR//RNA-seq//Invasion Assay qRT-PCR results indicated that circ_0051620 in GC was over-expressed in tumoral tissues and cell lines compared to the normal controls. Moreover, miR-338-3p was confirmed to be the target of circ_0051620. Overall overexpression of miR-338-3p inhibited the cell migration, invasion through inhibiting ADAM17 in GC cells. Yes Moreover, miR-338-3p was confirmed to be the target of circ_0051620. Overall overexpression of miR-338-3p inhibited the cell migration, invasion through inhibiting ADAM17 in GC cells. 35413598 hsa_circ_0009910 CircRNA Homo sapiens Stomach Neoplasms GC tumor tissues and cells Interaction(miR-361-3p/SNRPA axis.) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Circ_0009910 and SNRPA were upregulated in GC tumor tissues and cells. Circ_0009910 could sponge miR-361-3p, and miR-361-3p could target SNRPA. Further experiments confirmed that circ_0009910 positively regulated SNRPA by sponging miR-361-3p. Yes Knockdown of circ_0009910 or SNRPA could inhibit GC cell proliferation, migration, invasion, glycolysis, and promote apoptosis. 35098410 hsa_circ_0007360 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction(miR-762/ IRF7 Axis) IHC//Western Blot//Flow Cytometry//FISH//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In summary, our results revealed that activation of the circ0007360/miR-762/IRF7 axis is a novel mechanism for the attenuation of gastric cancer progression. Yes In summary, our results revealed that activation of the circ0007360/miR-762/IRF7 axis is a novel mechanism for the attenuation of gastric cancer progression. 35252169 hsa_circ_0044301 CircRNA Homo sapiens Stomach Neoplasms tissues and cancer cells Interaction(Hsa-miR-188-5p/DAXX Axis and MAPK Pathway) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//IF//RNA-seq//Luciferase Report Assay//Microarray//IHC//Transwell Assay CircRNA-0044301 was upregulated in tissues and cancer cells compared to its levels in controls, related to patient prognosis, and its specific siRNA-vivo could slow tumor growth.On the mechanism, it acted as a sponge of miRNA-188-5p, could regulate the downstream target DAXX, and modulated the effect of GDC-0994 on ERK1/2 and 5-FU in cells. CircRNA-0044301 was upregulated in tissues and cancer cells compared to its levels in controls, related to patient prognosis, and its specific siRNA-vivo could slow tumor growth. Yes CircRNA-0044301 was upregulated in tissues and cancer cells compared to its levels in controls, related to patient prognosis, and its specific siRNA-vivo could slow tumor growth. 36077718 hsa_circ_0000285 CircRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(miR-1278/FN1 axis ) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay Hsa_circ_0000285 was significantly overexpressed in the GC tissues. Hsa_circ_0000285 sponged miR-1278. Inhibition of miR-1278 in vitro reversed the effects of hsa_circ_0000285 silencing on GC progression. MiR-1278 targeted FN1, and silencing FN1 neutralized the effects of miR-1278 inhibitors on GC progression. Yes Silencing hsa_circ_0000285 inhibited cell proliferation and invasion, promoted apoptosis, and inhibited tumor development. 35535385 hsa_circ_0008287 CircRNA Homo sapiens Stomach Neoplasms gastric cancer cells Interaction(miR-548c-3p/CLIC1 r) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Transwell Assay circ_0008287, an upregulated circRNA in gastric cancer cells, augmented the viability as well as invasive and migratory potentials of gastric cancer cells. By competitively binding to miR-548c-3, circ_0008287 increased the expression of CLIC1, which impaired the function of CD8 + T cells and promoted their apoptosis. Yes circ_0008287, an upregulated circRNA in gastric cancer cells, augmented the viability as well as invasive and migratory potentials of gastric cancer cells. After downregulation of circ_0008287, in vivo tumorigenesis and metastasis were suppressed. 35905561 hsa_circ_0008035 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-1256/CEACAM6 axis) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay Circ_0008035 and CEACAM6 were significantly high-expressed in GC tissues and cells.MiR-1256 was a target of circ_0008035. The inhibition effect of circ_0008035 knockdown on the malignant behavior of GC cells could be reversed by miR-1256 inhibitor. In addition, CEACAM6 was a target of miR-1256. Overexpression of CEACAM6 partially restored the inhibitory effect of miR-1256 on cell progression. Yes Silencing of circ_0008035 reduced GC cell proliferation, migration, and invasion while enhancing apoptosis. Animal experiments confirmed the anti-tumor effect of circ_0008035 knockdown in vivo. 35220873 hsa_circ_0000081 CircRNA Homo sapiens Stomach Neoplasms tissues and cells Interaction( hsa-miR-423-5p/PDPK1 ) Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Microarray//Transwell Assay Using quantitative reverse transcription polymerase chain reaction (qRT-PCR), hsa_circ_0000081 (circRNA-0000081) expression was found to be up-regulated in tissues and cells and was negative correlated with patients' survival time.Finally, dual luciferase reporter, RNA immunoprecipitation, qRT-PCR, and western blotting assays were used to verify the targeting relationship between circRNA-000081 and miRNA-423-5p or miRNA-423-5p and 3-phosphoinositide-dependent kinase 1 (PDPK1). Using quantitative reverse transcription polymerase chain reaction (qRT-PCR), hsa_circ_0000081 (circRNA-0000081) expression was found to be up-regulated in tissues and cells and was negative correlated with patients' survival time. Yes Moreover, the knockdown or overexpression of circRNA-000081 could influence the proliferation, migration, and invasion potential of GC. 35302432 hsa_circ_0067934 CircRNA Homo sapiens Stomach Neoplasms GC cells Interaction(miR‑1301‑3p/KIF23 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay The results demonstrated that circ_0067934 expression was upregulated in GC cells, and circ_0067934 silencing significantly inhibited GC cell proliferation, migration and invasion. In conclusion, circ_0067934 may regulate the proliferation, invasion and migration of GC cells via the miR‑1301‑3p/KIF23 signaling axis, which may represent a novel therapeutic target for GC metastasis. Yes The results demonstrated that circ_0067934 expression was upregulated in GC cells, and circ_0067934 silencing significantly inhibited GC cell proliferation, migration and invasion. 35475447 circMYBL2 CircRNA Homo sapiens Stomach Neoplasms GC cells Interaction( miR-92b) BrdU//RNA Pull-Down//Northern Blot We found that GC tissues exhibited increased mature miR-92b levels but decreased precursor miR-92b and circ-MYBL2 levels. Circ-MYBL2 was detected in both the nucleus and cytoplasm in GC cells, and it directly interacted with precursor miR-92b. Moreover, circ-MYBL2 overexpression increased precursor miR-92b expression and decreased mature miR-92b level. Yes Furthermore, miR-92b (mature) increased GC cell proliferation, and circ-MYBL2 decreased GC cell proliferation and suppressed the effect of miR-92b on GC cell proliferation. 35644224 circFOXK2 CircRNA Homo sapiens Breast Neoplasms BC cells with high metastatic ability Interaction(IGF2BP3/miR-370 axis) Migration Assay//FISH//Luciferase Report Assay//RNA-seq//Invasion Assay The results showed that circRNA circFOXK2 was significantly increased in BC cells with high metastatic ability, and the upregulation of circFOXK2 was correlated with poor clinicopathological characteristics. Also. circFOXK2 could act with IGF2BP3, an RNA-binding protein, and miR-370 to synergistically promote BC metastasis. the upregulation of circFOXK2 was correlated with poor clinicopathological characteristics Yes Functional experiments demonstrated that overexpression of circFOXK2 promoted migration and invasion of BC cells. 34329193 circCDYL CircRNA Homo sapiens Breast Neoplasms HER2+ breast cancer tissue Interaction(miR-92b-3p) Western Blot//ISH//CCK8//qRT-PCR//FISH//Luciferase Report Assay CircCDYL was high-expressed in HER2+ breast cancer tissue, similar with that in HER2- breast cancer tissue. CircRNA pull down and miRNA deep-sequencing demonstrated the binding of miR-92b-3p and circCDYL. Interestingly, circCDYL did not act as miR-92b-3p sponge, but was degraded in miR-92b-3p-dependent silencing manner. Clinically, expression of circCDYL and miR-92b-3p was associated with clinical outcome of HER2+ breast cancer patients. Yes Over-expression of circCDYL promoted proliferation of HER2+ breast cancer cells but not through miR-1275-ULK1/ATG7-autophagic axis. 34395434 hsa_circ_0001944 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-142-5p/NFAT5 ) RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay Circ_0001944 was highly expressed in NSCLC, and NSCLC patients with high expression of circ_0001944 had a worse prognosis. Circ_0001944 was verified as a decoy for microRNA (miR)-142-5p, which targeted NFAT5 (nuclear factor of activated T cells 5). MiR-142-5p was downregulated while NFAT5 was upregulated in NSCLC. Both miR-142-5p inhibition and NFAT5 overexpression offset the suppressive impact of circ_0001944 silencing on proliferation, migration, invasion, and glycolysis of NSCLC cells. Circ_0001944 was highly expressed in NSCLC, and NSCLC patients with high expression of circ_0001944 had a worse prognosis. Yes Circ_0001944 silencing decreased xenograft tumor growth in vivo and repressed proliferation, migration, invasion, and glycolysis of NSCLC cells in vitro. 34040437 circSEC31A CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells interaction[Sponging miR-376a] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay Our data indicated that circSEC31A and SEC31A were upregulated in NSCLC tissues and cells.Our findings first identified that the knockdown of circSEC31A suppressed NSCLC malignant progression at least partly through modulating SEC31A expression by acting as a miR-376a sponge, providing a novel molecular target of NSCLC therapy. Yes CircSEC31A knockdown suppressed NSCLC cell migration, invasion, glycolysis and promoted apoptosis in vitro, as well as hindered tumor growth in vivo. 33204164 circTHBS1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[sponging miR-129-5p and regulating SOX4 expression] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining The expression of circTHBS1 was markedly higher in NSCLC patients than that in control group, and it was increased in patients with metastatic NSCLC compared with that in patients with non-metastatic NSCLC. CircTHBS1 promotes the proliferation and inhibits the apoptosis of NSCLC cells through targeting miR-129-5p and regulating SOX4 expression. Yes Moreover, the proliferative ability of the cells was weakened notably after transfection with small interfering (Si)-CircTHBS1, but it was enhanced remarkably after transfection with CircTHBS1-overexpression vector (OE). 33099906 circNFIX CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-212-3p/ADAM10 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our data revealed that circNFIX was overexpressed in NSCLC and predicted poor prognosis of NSCLC patients.: Our findings first identified that the knockdown of circNFIX, a highly expressed circRNA in NSCLC, exerted a repressive role in NSCLC malignant progression at least in part through targeting the miR-212-3p/ADAM10 axis, illuminating a novel understanding of circRNA regulation in NSCLC. Our data revealed that circNFIX was overexpressed in NSCLC and predicted poor prognosis of NSCLC patients. Yes CircNFIX knockdown suppressed NSCLC cell viability, migration, invasion and glycolysis in vitro and hampered tumor growth in vivo. 33061643 circDENND2A CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[MiR-34a/CCNE1 Signaling] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Here, we demonstrated that circDENND2A was down-regulated in NSCLC samples.We thought this study indicated that circDENND2A/miR-34a/CCNE1 may be a potential therapeutic target for NSCLC. Yes Loss-of-function assays showed circDENND2A knockdown suppressed cell growth via inducing cell cycle arrest and apoptosis and inhibited cell migration and invasion. 33033491 hsa_circ_100876 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung regulation[miR-636/RET axis] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay CircRNA_100876 knockdown notably suppressed the progression of NSCLC through regulation of miR-636/RET axis, which may serve as a potential target for treatment of NSCLC. Yes Silencing of circRNA_100876 notably inhibited the proliferation of NSCLC cells. Moreover, downregulation of circRNA_100876 significantly induce the apoptosis of NSCLC cells via mediation of apoptosis-related proteins. In addition, silencing of circRNA_100876 significantly inhibited migration and invasion of NSCLC cells. 33030101 circHIPK3 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines regulation[circHIPK3/miR-107/BDNF axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results showed that circHIPK3 expression was upregulated in NSCLC cells. These results indicate that circHIPK3 promotes tumor progression through a new circHIPK3/miR-107/BDNF axis, which offers potential markers and medical treatment for NSCLC. Yes circHIPK3 knockdown inhibited the migration and proliferation of NSCLC cells by promoting the expression of miR-107. 33015172 circMEMO1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,blood regulation[miR-101-3p/KRAS axis] qRT-PCR//MTT//RNA Pull-Down//RIP Circ-MEMO1 was up-regulated in NSCLC, and high expression of circ-MEMO1 predicted poor prognosis in NSCLC patients. Circ-MEMO1 facilitated the progression and glycolysis of NSCLC through regulating miR-101-3p/KRAS axis. Circ-MEMO1 was up-regulated in NSCLC, and high expression of circ-MEMO1 predicted poor prognosis in NSCLC patients. Yes Circ-MEMO1 accelerated the proliferation, cell cycle progression, and glycolytic metabolism and inhibited the apoptosis of NSCLC cells. 33005174 hsa_circ_0000376 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[ miR-1182/NOVA2 Network] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay Circ_0000376 was upregulated in NSCLC, and its high expression was related to the poor overall survival of NSCLC patients.Circ_0000376 promoted NSCLC progression by regulating the miR-1182/NOVA2 axis, suggesting that circ_0000376 might be a potential biomarker for NSCLC treatment. Circ_0000376 was upregulated in NSCLC, and its high expression was related to the poor overall survival of NSCLC patients. Yes However, silencing of circ_0000376 could inhibit the glycolysis, viability, migration, and invasion of hypoxia-induced NSCLC cells. 32922073 hsa_circ_0000735 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue regulation[miR-940/BMPER Axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0000735 was upregulated and significantly correlated with overall survival in patients with NSCLC.Circ_0000735 regulated proliferation, migration, invasion, and glycolysis in NSCLC cells by targeting miR-940/BMPER axis. Circ_0000735 was upregulated and significantly correlated with overall survival in patients with NSCLC. Yes In addition, the loss-of-functional experiments revealed that knockdown of circ_0000735 repressed proliferation, migration, invasion and glycolysis of NSCLC cells and tumor growth in vivo, which was overturned by overexpression of BMPER. 32922033 hsa_circ_102179 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[miR-330-5p/HMGB3 axis] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircRNA_102179 was overexpressed in NSCLC tissues and cells compared with normal lung tissues and human bronchial epithelial cells (HBEs). Our results reveal that circRNA_102179 facilitates the proliferation, migration, and invasion of NSCLC cell via modulating miR-330-5p/ HMGB3 axis in NSCLC cells. Yes The down-regulation of circRNA_102179 markedly reduced the proliferation, migration, and invasion of NSCLC cells. 32911346 hsa_circ_103993 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells regulation[miR-1271/ERG signaling pathway] CCK8//qRT-PCR//Flow Cytometry//Western Blot CircRNA_103993 and ERG were significantly up-regulated while miR-1271 was significantly down-regulated in NSCLC cells.The CircRNA_103993 /miR-1271/ ERG axis had an important effect on the proliferation and apoptosis of NSCLC cells. Yes Knockdown of CircRNA_103993 and high expression of miR-1271 significantly inhibited NSCLC cell proliferation and promoted apoptosis. 32894545 hsa_circ_0020123 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[THBS2,miR-590-5p] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The expression of circ_0020123 was upregulated in NSCLC tissues and cells.Circular RNA circ_0020123 regulated THBS2 by sponging miR-590-5p to promote cell proliferation and migration and inhibit cell apoptosis in NSCLC cells. Yes Functionally, circ_0020123 downregulation inhibited the proliferation and migration and promoted the apoptosis of NSCLC cells. 32831647 circEPSTI1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[ inhibiting TRIM24 via miR-1248 upregulation] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay We found that circEPSTI1 expression was significantly elevated in NSCLC. In summary, our data demonstrate that downregulation of circEPSTI1 represses the proliferation and invasion of NSCLC by inhibiting TRIM24 via miR-1248 upregulation. Yes In vitro experiments elucidated that knockdown of circEPSTI1 caused a significant reduction in NSCLC cell proliferation and invasion. 32828310 circEPSTI1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-145/HMGB3 Axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircEPSTI1 was abnormally up-regulated in NSCLC tissues and cells in comparison with that in normal tissues and cells.CircEPSTI1 aggravated the progression of NSCLC through elevating the expression of HMGB3 via sponging miR-145. The high expression of circEPSTI1 was associated with the low survival rate of NSCLC patients. Yes CircEPSTI1 accelerated the proliferation, colony formation and motility of NSCLC cells in vitro. CircEPSTI1 silencing restrained the NSCLC tumor growth in vivo. 32801908 circSLC7A6 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[circ-SLC7A6/miR-21 axis] RNA Pull-Down//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Transwell Assay Circ-SLC7A6 was significantly downregulated in NSCLC tissues in comparison to para-carcinoma tissues. Overall, our study demonstrates that circ-SLC7A6 is a novel tumor suppressor in NSCLC, targeting circ-SLC7A6/miR-21 axis may be a promising treatment for NSCLC patients. Low circ-SLC7A6 was closely associated with larger tumor size, lymph node metastasis, advanced clinical stage and adverse outcome. Yes Importantly, in vivo xenograft tumor experiments showed that reintroduction of circ-SLC7A6 retarded tumor growth as well as decreased lung metastatic nodules. 32794418 circARHGAP10 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues, cells, and serum-derived exosomes regulation[miR-638/FAM83F Axis] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay circARHGAP10 was upregulated in NSCLC tissues, cells, and serum-derived exosomes. Inhibition of serum-derived exosomes-mediated circARHGAP10 curbed NSCLC progression through the miR-638/FAM83F axis. Yes circARHGAP10 depletion repressed proliferation, migration, invasion, and glycolysis of NSCLC cells in vitro, and curbed tumor growth in vivo. 32783691 circRACGAP1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues, cells regulation[miR-144-5p/CDKL1 signaling pathway] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//EdU Staining CircRACGAP1 was highly expressed and miR-144-5p was inhibited both in NSCLC tissues and cell lines, suggesting their negative correlation in NSCLC. In summary, our study revealed a novel machinery of circRACGAP1/miR-144-5p/CDKL1 for the NSCLC tumorigenesis and development, providing potential diagnostic and therapeutic targets for NSCLC. Yes Knockdown of circRACGAP1 suppressed cell proliferation via arresting the cell cycle. 32778770 circMAGI3 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues, cells regulation[miR-515-5p/HDGF] qRT-PCR Clinically, circMAGI3 was significantly up-regulated in NSCLC tissue and cells, which was closely correlated with unfavorable outcome for NSCLC patients.Collectively, this research identified the oncogenic role of circMAGI3 in the tumorigenesis through miR-515-5p/HDGF axis, providing a vital theoretical basis for treatment of NSCLC. Clinically, circMAGI3 was significantly up-regulated in NSCLC tissue and cells, which was closely correlated with unfavorable outcome for NSCLC patients. Yes Functionally, circMAGI3 promoted the glycolysis and proliferation of NSCLC cells. 32774748 hsa_circ_0067934 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[ miR-1182/KLF8 axis and activating Wnt/β-catenin pathway] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Transwell Assay We found that circ_0067934 and KLF8 were up-regulated, while miR-1182 was down-regulated in NSCLC tissues and cells. In conclusion, Circ_0067934 acted as a competing endogenous RNA to facilitate NSCLC progression by regulating the miR-1182/KLF8 axis and activating Wnt/β-catenin pathway. Yes Circ_0067934 knockdown blocked proliferation, migration, invasion and EMT and induced apoptosis in NSCLC cells. 32768951 hsa_circ_0000376 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue regulation[repressing miR-384] CCK8//qRT-PCR//Luciferase Report Assay//BrdU//Transwell Assay Circ_0000376 expression in NSCLC clinical samples was up-regulated and this was linked to unfavorable pathological parameters.Mechanically, circ_0000376 overexpression could bind with miR-384 and repress its expression. Yes Circ_0000376 markedly accelerated the proliferation and metastasis, and enhanced chemoresistance of NSCLC cells. 32716343 circBIRC6 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patient samples and cell lines interaction[targeting miR-4491] CCK8//qRT-PCR//Colony Formation Assay//Flow Cytometry We found that expression levels of circ-BIRC6 in NSCLC patient samples and cell lines were elevated. These findings demonstrate that circ-BIRC6 functions as a critical regulator of proliferation and apoptosis via binding to and negatively regulating miR-4491, suggesting that circ-BIRC6 might be a potential target for treatment of NSCLC. Yes Small interfering RNA (siRNA)-mediated circ-BIRC6 knockdown suppressed cell proliferation, colony formation, migration and invasion, and promoted apoptosis in NCI-H460 and A549 cells. 33177288 hsa_circ_0001869 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines interaction[sponging miR-638 and promoting FOSL2 expression] IHC//Western Blot//CCK8//qRT-PCR//Flow Cytometry//FISH//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//Transwell Assay The data advised that hsa_circ_0001869 expression was increased in NSCLC cell lines and tissues.Present investigation discovered that hsa_circ_0001869 enhanced NSCLC progression via sponging miR-638 and promoting FOSL2 expression. High hsa_circ_0001869 expression had negatively correlation with the NSCLC patients prognosis. Yes hsa_circ_0001869 downregulation decreased tumor proliferation, invasion and migration by promoting miR-638 expression and decreasing FOSL2 expression. 33221767 circLDLRAD3 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-137/SLC1A5 axis] Western Blot//Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this study, we found that circ-LDLRAD3 was high-expressed and miR-137 was low-expressed in NSCLC tissues and cells compared to their normal counterparts, which showed negative correlations in NSCLC tissues. Taken together, this in vitro study found that knock-down of circ-LDLRAD3 inhibited the development of NSCLC by regulating miR-137/SLC1A5 axis. Yes In addition, knock-down of circ-LDLRAD3 and miR-137 overexpression promoted NSCLC cell apoptosis, and inhibited cell proliferation and invasion. 32658600 hsa_circ_0001313 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell line regulation[microRNA-452/HMGB3/ERK/MAPK Axis] qRT-PCR Abnormally elevated circ0001313 and decreased miR-452 in NSCLC cells were observed.We highlighted that silencing of circ0001313 blunted the ERK/MAPK pathway via the miR-452/HMGB3 axis, thereby inhibiting NSCLC cell proliferation and invasion. Yes Circ0001313 silencing or miR-452 overexpression significantly reduced NSCLC cell proliferation and invasion. 33328759 circZFR CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and corresponding adjacent normal lung tissues,cell line (HBE A549, H460, H1703, PC9 and H1299) Interaction[miR-101-3p;CUL4B] CCK8//qRT-PCR//Transwell Assay//FISH Our results showed that circZFR expressions were significantly Expression[Expression[up-expression]-expression]regulated in NSCLC tissues and cell lines. KnockExpression[down-expression] of circZFR significantly inhibited the cell proliferation, migration and invasion of NSCLC cells in vitro. Furthermore, we demonstrated that circZFR acted as a sponge to absorb microRNA-101-3p (miR-101-3p) and promoted cullin 4B (CUL4B) expression Yes KnockExpression[down-expression] of circZFR significantly inhibited the cell proliferation, migration and invasion of NSCLC cells in vitro. 31407591 F-circSR1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines(H1299 and A549) Regulation[Expression[Expression[highly expressed]-expression]-regulated] qRT-PCR//Wound Healing Assay//MTT//Transwell Assay Transwell migration assays show that both F-circSRs significantly promoted cell migration in both cells (Fig. 2d), which were further confirmed by wound healing assays (Fig. 2e, f). Yes Functional studies through gain- and loss-of-function strategies showed that both F-circSRs promote cell migration in lung cancer cells, whereas they have little effect on cell proliferation. 31118036 F-circSR2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines(H1299 and A550) Regulation[Expression[Expression[highly expressed]-expression]-regulated] qRT-PCR//Wound Healing Assay//MTT//Transwell Assay Transwell migration assays show that both F-circSRs significantly promoted cell migration in both cells (Fig. 2d), which were further confirmed by wound healing assays (Fig. 3e, f). Yes Functional studies through gain- and loss-of-function strategies showed that both F-circSRs promote cell migration in lung cancer cells, whereas they have little effect on cell proliferation. 31118036 hsa_circ_0003645 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues, cell lines(16HBE, H358, H1299, H1581, and A549) Interaction[miR-1179/TMEM14A pathway] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The data demonstrated an Expression[Expression[up-expression]-expression]regulation of circ_0003645 in patients' tissue specimens and cells. Moreover, circ_0003645 acted as a ceRNA to sponge miR-1179, which resulted in the elevation of TMEM14A expression and facilitated cell progression. Overexpression of circ_0003645 in tissues was related to advanced TNM stages, positive lymph node invasion and unfavorable prognosis for the patients with NSCLC. Yes In addition, gain and loss of function assays uncovered that circ_0003645 functioned as an oncogene in NSCLC cells. 30853176 circFOXM1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[ circ-FOXM1/miR-1304-5p/PPDPF/MACC1 signaling] Other The results indicated that circ-FOXM1 overexpression was observed in NSCLC tissues and closely associated with lymph node invasion, higher TNM stage, and unfavorable prognosis.Mechanistically, miR-1304-5p was discovered as a direct target of circ-FOXM1. Circ-FOXM1 Expression[Expression[up-expression]-expression]regulated the level of pancreatic progenitor cell differentiation and proliferation factor (PPDPF) and metastasis-associated in colon cancer 1 (MACC1) by sponging miR-1304-5p, thereby increasing the proliferation and invasion of NSCLC cells. The results indicated that circ-FOXM1 overexpression was observed in NSCLC tissues and closely associated with lymph node invasion, higher TNM stage, and unfavorable prognosis Yes Furthermore, knockExpression[down-expression] and ectopic expression of circ-FOXM1 significantly inhibited and promoted the growth, migration and invasion of NSCLC cells, respectively. 30954221 circPIP5K1A CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell line Interaction[miR-600/HIF-1α] FISH//Luciferase Report Assay//PCR The data demonstrated that circPIP5K1A expression was increased in NSCLC cells.The circPIP5K1A may function as an miR-600 sponge to facilitate NSCLC proliferation and metastasis by promoting HIF-1α. A bifluorescein reporter experiment confirmed that miR-600 was the circPIP5K1A target, and miR-600 interacted with the 3' untranslated region of HIF-1α. These results show that circPIP5K1A acted as a tumor promoter through a novel circPIP5K1A/miR-600/HIF-1α axis, which provides candidate markers and therapeutic targets for NSCLC. Yes The circPIP5K1A knockdown sExpression[up-expression]pressed NSCLC cell metastasis and proliferation by promoting expression of miR-600. Overexpression of miR-600 inhibited HIF-1α-mediated metastasis and proliferation of NSCLC cell by downregulating the endothelial mesenchymal transition-related proteins, Snail and vimentin, and Expression[up-expression]regulating E-cadherin. 31241217 hsa_circ_0026134 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[ sponging miR-1256 and miR-1287] qRT-PCR//Luciferase Report Assay Circ_0026134 was frequently upregulated in NSCLC samples and cell lines. For the part of mechanism exploration, miR-1256 and miR-1287 were proved to be sponged by circ_0026134. Rescue experiments further indicated that the oncogenic role of circ_0026134 was dependent on its regulation of miR-1256 and miR-1287. Yes Furthermore, we observed that downregulation of circ_0026134 attenuated NSCLC cell proliferation and metastatic properties and induced cell apoptosis. The overexpression of circ_0026134 in NSCLC cells caused the opposite effect. 30970529 circFGFR1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[sponging miR-381-3p] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Here, we report that circFGFR1 is upregulated in NSCLC tissues, and circFGFR1 expression is associated with deleterious clinicopathological characteristics and poor prognoses for NSCLC patients.Mechanistically, circFGFR1 could directly interact with miR-381-3p and subsequently act as a miRNA sponge to upregulate the expression of the miR-381-3p target gene C-X-C motif chemokine receptor 4 (CXCR4), which promoted NSCLC progression and resistance to anti-programmed cell death 1 (PD-1)- based therapy. Yes Forced circFGFR1 expression promoted the migration, invasion, proliferation, and immune evasion of NSCLC cells. 31815619 circHIPK3 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissue Regulation[MIR124-3p-STAT3-PRKAA/AMPKα signaling] qRT-PCR//Western Blot Mechanistically, we uncovered that autophagy was induced upon loss of circHIPK3 via the MIR124-3p-STAT3-PRKAA/AMPKa axis in STK11 mutant lung cancer cell lines (A549 and H838). STAT3 abrogation as well as transfection with a MIR124-3p mimic, recapitulated the induction of autophagy. We also demonstrated antagonistic regulation on autophagy between circHIPK3 and linear HIPK3 (linHIPK3). We therefore propose that the ratio between circHIPK3 and linHIPK3 (C:L ratio) may reflect autophagy levels in cancer cells. We observed that a high C:L ratio (>0.49) was an indicator of poor survival, especially in advanced-stage NSCLC patients. These results support that circHIPK3 is a key autophagy regulator in a subset of lung cancer and has potential clinical use as a prognostic factor. The circular RNA HIPK3 (circHIPK3) functions as an oncogene and autophagy regulator may potential use as a prognostic marker and therapeutic target in lung cancer. Yes . Our results provided evidence that silencing of circHIPK3 significantly impaired cell proliferation, migration, invasion and induced macroautophagy/autophagy. 31232177 hsa_circ_000984 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction[Wnt/β-catenin pathway] CCK8//qRT-PCR//Colony Formation Assay//Western Blot We found that hsa_circ_000984 was highly expressed in NSCLC tissues and cell lines and correlated with advanced TNM stage and lymph nodes metastasis. Moreover, hsa_circ_000984 displayed its oncogenic roles by modulating the activation of Wnt/β-catenin pathway, which was demonstrated by measuring the expression levels of, β-catenin, c-myc, and cyclin D1. We found that hsa_circ_000984 was highly expressed in NSCLC tissues and cell lines and correlated with advanced TNM stage and lymph nodes metastasis. The clinical assays indicated that patients with high hsa_circ_000984 expression had shorter overall survival and disease-free survival. Yes The functional investigations showed that the knockdown of hsa_circ_000984 suppressed NSCLC cells proliferation, migration, invasion, and EMT. 31081091 circZKSCAN1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[circ-ZKSCAN1/miR-330-5p/FAM83A feedback loop] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our results showed that circ-ZKSCAN1 was significantly up-regulated in NSCLC. Importantly, circ-ZKSCAN1 can act as a sponge of carcinogenic miR-330-5p to increase the expression of FAM83A, resulting in the inhibition of MAPK signal transduction pathway, thus promoting the progress of NSCLC. Interestingly, the increase in FAM83A expression caused by circ-ZKSCAN1 overexpression could in turn promote the expression of circ-ZKSCAN1. Our results showed that circ-ZKSCAN1 was significantly up-regulated in NSCLC, closely related to malignant characteristics and poor prognosis, and clinically related to tumor size and clinical stage. Yes Subsequent experiments showed that circ-ZKSCAN1 could inhibit the growth of NSCLC cells in vitro and in vivo. 32010565 hsa_circ_0004015 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[circ_0016760/miR-1183/PDPK1 signaling pathway ] qRT-PCR//Luciferase Report Assay Here, we identified hsa_circ_0004015 was upregulated in NSCLC tissues, and was associated with the poor overall survival rate of NSCLC patients.In conclusion, circ_0016760/miR-1183/PDPK1 signaling pathway might play vital roles in the tumorigenesis of NSCLC. Here, we identified hsa_circ_0004015 was upregulated in NSCLC tissues, and was associated with the poor overall survival rate of NSCLC patients. Yes Knockdown of hsa_circ_0004015 significantly decreased cell viability, proliferation, and invasion, whereas overexpression exhibited opposed effects in vivo and in vitro. 30509491 hsa_circ_0023404 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Regulation[miR-217/ZEB1 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The expression of hsa_circ_0023404 was upregulated in NSCLC tissues, as well as in NSCLC cell lines. hsa_circ_0023404 promotes the proliferation, migration and invasion of NSCLC cells by regulating miR-217/ZEB1 axis, providing a fresh perspective on circRNAs in NSCLC development. High hsa_circ_0023404 expression predicted short overall survival in NSCLC. Yes Functionally, knockdown of hsa_circ_0023404 inhibited the proliferation, migration and invasion of NSCLC cells. 31496723 hsa_circ_0078767 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[ inhibiting miR-330-3p] Western Blot//Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay//Transwell Assay Circ_0078767 and RASSF1A were downregulated, while miR-330-3p was upregulated in NSCLC tissues than that in adjacent tissues.Circ_0078767 could suppress NSCLC progression by inhibiting miR-330-3p, which thereby increased RASSF1 levels. Yes The overexpression of circ_0078767 and RASSF1A or the underexpression of miR-330-3p significantly suppressed NSCLC cell viability, cell cycle progression and invasion while also significantly promoting cell apoptosis. Additionally, these modulations significantly suppressed in vivo tumour growth. 30507050 hsa_circ_0000003 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Regulation[miR-338-3p/IRS2 axis] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//BrdU//Transwell Assay The expression of circ_0000003 was significantly high in NSCLC tissues and cell lines.Circ_0000003 promotes the proliferation and metastasis of NSCLC cells via modulating miR-338-3p/IRS2 axis. The expression of circ_0000003 was significantly high in NSCLC tissues and cell lines, and its high expression level was notably correlated with lymph node metastasis andTNM staging. Yes In vitro experiments showed that overexpression of circ_0000003 facilitated the proliferation, migration, invasion and inhibited the apoptosis of NSCLC cells, while the knockdown of circ_0000003 had the opposite effect.In vivo experiments revealed that knockdown of circ_0000003 impeded tumor growth and metastasis. 31736412 circSATB2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Expression[highly expressed] qRT-PCR//FISH//Luciferase Report Assay//Western Blot Data from the investigation showed that circSATB2 was highly expressed in NSCLC cells and tissues. Yes Furthermore, circSATB2 can be transferred by exosomes and promote the proliferation, migration and invasion of NSCLC cells, as well as induce abnormal proliferation in normal human bronchial epithelial cells. 32493389 hsa_circ_101237 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell line interaction[miRNA-490-3p/MAPK1 axis] CCK8//RIP//qRT-PCR//Luciferase Report Assay//Transwell Assay The study found an elevation in the expression of Hsa_circRNA_101237 in both NSCLC tissues and cell line. To sum up, as revealed by the study, hsa_circRNA_101237 promoted the expression of MAPK1 via miRNA-490-3p sponge, thus affecting the NSCLC as an important onco-circRNA. High Hsa_circRNA_101237 expression predicted poor survival in NSCLC. Yes Meanwhile, we found that hsa_circRNA_101237 expression sponged miR-490-3p to enhance MAPK1 expression, thus significantly promoting NSCLC cell lines proliferation, migration, and invasion. 32494004 hsa_circ_0016760 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell line interaction[sponging miR-145-5p/FGF5] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Hsa_circ_0016760 was aberrantly upregulated in NSCLC, which was associated with poor prognosis of patients (P<0.05).In conclusion, hsa_circ_0016760 exacerbated the malignant development of NSCLC by sponging miR‑145‑5p/FGF5. Hsa_circ_0016760 was aberrantly upregulated in NSCLC, which was associated with poor prognosis of patients (P<0.05). Yes Hsa_circ_0016760 silencing suppressed NSCLC cell proliferation, migration and invasion in vitro (P<0.01). 33416186 hsa_circ_0004050 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[ERK/JNK signaling pathway] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot The expression of hsa_ circ_0004050 was significantly lower in tumor tissues than that in para-carcinoma tissues in NSCLC patients. In terms of its mechanism, hsa_circ_0004050 could markedly increase the protein expression of DUSP9 via targeting miR-1233-3p in A549 cells, thereby inhibiting the ERK/JNK signaling pathway. The expression of hsa_circ_0004050 was significantly correlated with TNM stage, tumor size and lymph node metastasis. The results of survival analysis showed that the survival time of patients with a high expression of hsa_circ_0004050 was obviously prolonged. Yes According to the results of phenotype assay, hsa_circ_0004050 could promote apoptosis and inhibit proliferation of A549 cells. 33348975 hsa_circ_0007580 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-545-3p] Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay Hsa_circ_0007580 was upregulated in NSCLC tumor tissues, and the expression of its host gene (protein kinase Ca) correlated negatively with overall survival.Dual luciferase reporter assays indicated that miR-545-3p can bind to hsa_circ_0007580 (suggesting that hsa_circ_0007580 sponges miR-545-3p) and to protein kinase Ca (suggesting that miR-545-3p directly inhibits this gene). Hsa_circ_0007580 was upregulated in NSCLC tumor tissues, and the expression of its host gene (protein kinase Ca) correlated negatively with overall survival. Yes Knocking down hsa_circ_0007580 inhibited proliferation and invasion by NSCLC cells and induced their apoptosis. 32681720 circMET CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-145-5p/CXCL3 axis] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//IHC//Transwell Assay In this study, the present results demonstrated that circMET expression was significantly higher in NSCLC tissues than in peritumoral tissues using quantitative real-time polymerase chain reaction. Collectively, circMET regulates the miR-145-5p/CXCL3 axis and serves as a novel, promising diagnostic and prognostic biomarker in patients with NSCLC. Notably, NSCLC patients with a large tumor diameter, poor differentiation and lymphatic metastasis had high RNA levels of circMET. Moreover, high circMET expression served as an independent risk factor for short overall survival (OS) and progression-free survival (PFS) in NSCLC patients. Yes Next, we validated that circMET overexpression can enhance NSCLC cell proliferation, metastasis, and immune evasion in vitro. 32614785 hsa_circ_0053063 CircRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction(hsa-miR-330-3p/PDCD4 axis) Western Blot//qRT-PCR//FISH//MTT//Luciferase Report Assay//Colony Formation Assay Hsa_circ_0053063 was mainly located in the cytoplasm and activated in BC tissues and cell lines. In conclusion, hsa_circ_0053063 inhibits breast cancer cell proliferation via hsa_circ_0053063/hsa-miR-330-3p/PDCD4 axis, which may provide a new therapeutic target for BC patients. Yes Moreover, hsa_circ_0053063 inhibited cell viability, proliferation, and progression of BC through the negative regulation of miR-330-3p. 33744861 hsa_circ_0003222 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and LCSCs Interaction(miR-527) In Vivo Experiment We found that hsa_circ_0003222 was highly expressed in NSCLC tissues and LCSCs. Higher levels of hsa_circ_0003222 were associated with the stage, metastasis, and survival rate of patients with NSCLC. Yes Reduced levels of hsa_circ_0003222 decreased tumor cell proliferation, migration, invasion, stemness-like properties, and chemoresistance. The silencing of hsa_circ_0003222 was found to downregulate PHF21B expression and its downstream, β-catenin by relieving the sponging effect of miR-527. 34433810 hsa_circ_0000735 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues Interaction(miR-635/FAM83F axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0000735 was a highly expressed circRNA in NSCLC. Yes Silenced circ_0000735 could inhibit NSCLC cell proliferation, migration, invasion, glycolysis, and increase apoptosis. MiR-635 could be sponged by circ_0000735, and its inhibitor could reverse the regulation of circ_0000735 silencing on NSCLC progression. 33560141 hsa_circ_0000517 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues and cells Interaction(miR-330-5p/YY1 signal pathway) RNA Pull-Down//qRT-PCR//Western Blot The results demonstrated that circ_0000517 was highly expressed in lung cancer tissues and cells, and overexpression of circ_0000517 was negatively correlated with the prognosis of NSCLC patients. Further study found that circ_0000517 targeted miR-330-5p and miR-330-5p targeted YY1. overexpression of circ_0000517 was negatively correlated with the prognosis of NSCLC patients. Yes Silencing of circ_0000517 significantly inhibited the proliferation, glycolysis, and glutamine decomposition of NSCLC cells in vitro and repressed the growth of xenografted tumors in vivo. Moreover, knockdown of circ_0000517 attenuated the expression of PCNA, HK2, LDHA, ASCT2, and GLS1. 34405943 hsa_circ_0006349 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissues and NSCLC cell lines Interaction(microRNA-98/MKP1 Axis) Western Blot//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay Circ_0006349 and MKP1 were upregulated, and miR-98 was poorly expressed in the collected tumor tissues and the acquired NSCLC cell lines. Circ_0006349 was identified as a sponge for miR-98 to elevate MKP1 expression. Yes Silencing of circ_0006349 suppressed proliferation and increased apoptosis of Calu-3 and H1299 cells, and it reduced glycolysis, glucose uptake, and the production of lactate in cells. Upon circ_0006349 knockdown, further downregulation of miR-98 or upregulation of MKP1 restored the malignant behaviors of cells. 34604211 circPITX1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Forty-one paired NSCLC tumor tissues and adjacent normal tissues Interaction(miR-1248/CCND2 Axis) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay Circ-PITX1 was upregulated in NSCLC and its silencing could inhibit the proliferation, migration, invasion, cell cycle process, glycolysis, glutamine metabolism, and promote the apoptosis of NSCLC cells in vitro, as well as reduced tumor growth in vivo. In the terms of mechanism, we found that circ-PITX1 could act as a sponge of miR-1248, and miR-1248 could target CCND2. Yes Circ-PITX1 was upregulated in NSCLC and its silencing could inhibit the proliferation, migration, invasion, cell cycle process, glycolysis, glutamine metabolism, and promote the apoptosis of NSCLC cells in vitro, as well as reduced tumor growth in vivo. 33727831 hsa_circ_0089823 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Sixty-seven NSCLC samples and 18 adjacent non-cancer samples Interaction(miRNA/SOX4 axis) Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Colony Formation Assay//IF Circ_0089823, an up-regulated circRNA (5.4-fold, P = 0.0017), was further investigated through loss-of-function and gain-of-function. Furthermore, SOX4, a tumor-promoting transcription factor, was highly expressed in NSCLC tissues and positively regulated by circ_0089823. Bioinformatic analysis revealed several potential binding sites for miR-507, miR-557, miR-579-3p and miR-1287-5p in circ_0089823 and SOX4 3'-untranslated region, which was later confirmed by luciferase reporter assay. The circ_0089823 level in NSCLC samples was related to the gender, tumor size, pathological type, TNM stage and smoking history. Yes Knockdown of circ_0089823 suppressed cell proliferation, induced cell cycle arrest and apoptosis of NSCLC cells in vitro. Additionally, circ_0089823-silenced xenografts grew much slowly. On the contrary, its over-expression promoted the malignant behaviors of NSCLC cells. 34311177 hsa_circ_0001287 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue specimens Interaction(miR-21/PTEN axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU//Colony Formation Assay//Transwell Assay We reported that circ_0001287 expression was down-modulated in NSCLC tissues and cell lines. Circ_0001287 could adsorb miR-21 and repress its expression, and indirectly up-modulate PTEN expression in NSCLC cells. Besides, circ_0001287 low expression was associated with low differentiation and positive lymph node invasion of NSCLC. Yes Circ_0001287 overexpression suppressed the multiplication, migration, invasion, and radioresistance of NSCLC cells, whereas circ_0001287 knockdown promoted the above phenotypes. 33467964 circUSP7 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-934.) RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//ELISA//IHC The expression levels of circUSP7 were higher in human NSCLC tissues than in matched adjacent nontumour tissues. Increased levels of circUSP7 indicate poor clinical prognosis and CD8+ T cell dysfunction in patients with NSCLC. Furthermore, circUSP7 inhibits CD8+ T cell function by upregulating the expression of Src homology region 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) via sponging miR-934. Finally, we show that circUSP7 may promote resistance to anti-PD1 immunotherapy in NSCLC patients. Yes The circUSP7 found in NSCLC patient plasma is predominantly secreted by NSCLC cells in an exosomal manner, and circUSP7 inhibits IFN-γ, TNF-α, Granzyme-B and Perforin secretion by CD8+ T cells. 34753486 hsa_circ_0008037 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Interaction(miR-433-3p/NUCKS1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay Circ_0008037 was upregulated in NSCLC tissues and cells. Mechanically, circ_0008037 regulated nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate 1 (NUCKS1) expression via sponging miR-433-3p. Yes Circ_0008037 downregulation reduced tumor growth in vivo and repressed proliferation, migration, invasion, and decreased the Warburg effect of NSCLC cells in vitro. 34850570 hsa_circ_0020123 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-142-3p/ZFX axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//migration assay//Luciferase Report Assay//Invasion Assay Our results showed that circ_0020123 was upregulated in NSCLC, and its knockdown could suppress NSCLC cell proliferation, migration, invasion, and promote apoptosis. In addition, circ_0020123 silencing inhibited NSCLC tumorigenesis by the miR-142-3p/ZFX axis. Yes Our results showed that circ_0020123 was upregulated in NSCLC, and its knockdown could suppress NSCLC cell proliferation, migration, invasion, and promote apoptosis. 33633466 hsa_circ_0069244 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patients Interaction(miR-346-5p/XPC axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//BrdU We reported that circ_0069244 was remarkably down modulated in NSCLC and was linked to shorter survival and poor tumor histological grade in NSCLC patients. Furthermore, miR-346-5p was unveiled to be a downstream target of circ_0069244, and miR-346-5p specifically modulated XPC expression. We reported that circ_0069244 was remarkably down modulated in NSCLC and was linked to shorter survival and poor tumor histological grade in NSCLC patients. Yes Functionally, circ_0069244 repressed NSCLC cell proliferation and migration. 34228324 circDTL CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Interaction(miR-1287-5p/GPX4 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Invasion Assay CircDTL was found to be upregulated and acted as an oncogene in NSCLC cells. It was identified that circDTL exerts its oncogenic effects via the circDTL/miR-1287-5p/GPX4 axis and GPX4 inhibits both ferroptosis and apoptosis. Yes Knockdown of circDTL promoted both apoptosis and ferroptosis of NSCLC cells. Finally, this study showed that silencing of circDTL promoted the sensitivity of NSCLC cells to chemotherapeutic agents and inhibited the growth of tumors in vivo. 34621297 hsa_circ_0000677 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung non-small cell lung cancer (NSCLC) patients Interaction(microRNA-106b-5p/CCND1 ) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//IF Here, we show that circular RNA circ_0000677 was overexpressed and correlated with poor prognosis in non-small cell lung cancer (NSCLC) patients. In mechanism, circ_0000677 acted as a sponge of microRNA-106b and further regulated CCDND1 gene expression in NSCLC cells by dual luciferase activity assay and their expression examination. Here, we show that circular RNA circ_0000677 was overexpressed and correlated with poor prognosis in non-small cell lung cancer (NSCLC) patients. Yes Functionally, circ_0000677 knockdown markedly inhibited proliferation of NSCLC cells by observing of immunofluorescence staining of Ki67, clone formation assay, and xenograft experiments. 34519258 hsa_circ_0074027 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-2467-3p/RHOA ) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay Circ_0074027 expression was prominently elevated in NSCLC tissues and cell lines. Circ_0074027 interacted with miR-2467-3p, and RHOA was a target of miR-2467-3p in NSCLC cells. RHOA silencing blocked the malignant potential of NSCLC cells. Yes Circ_0074027 knockdown or miR-2467-3p overexpression suppressed cell proliferation, migration and invasion and facilitated cell apoptosis of NSCLC cells. Circ_0074027 silencing restrained the malignant phenotypes of NSCLC cells largely through up-regulating miR-2467-3p. Circ_0074027 knockdown notably blocked xenograft tumor growth in vivo. 33687619 circIGF2BP3 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression(highly expressed) Western Blot//CCK8//qRT-PCR//RIP//IP//IHC We demonstrated that circIGF2BP3 (hsa_circ_0079587) expression was increased in NSCLC and negatively correlated with CD8+ T cell infiltration. Collectively, the PKP3/PD-L1 signature and the infiltrating CD8+ T cell status stratified NSCLC patients into different risk groups. Yes Functionally, elevated circIGF2BP3 inactivated cocultured T cells in vitro and compromised antitumor immunity in an immunocompetent mouse model, and this effect was dependent on CD8+ T cells. 34416901 circPIP5K1A CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues, serum samples, and cells Interaction(miR-101/ABCC1 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_PIP5K1A and ABCC1 were overexpressed and miR-101 was downregulated in NSCLC tissues, serum samples, and cells. MiR-101 was a direct target of circ_PIP5K1A, and its knockdown reversed the effects of circ_PIP5K1A silence on inhibition of NSCLC progression and promotion of cisplatin sensitivity. Moreover, ABCC1 was a downstream target of miR-101, and miR-101 overexpression inhibited the progression of NSCLC cells and increased cisplatin sensitivity by targeting ABCC1. Yes Knockdown of exosomal circ_PIP5K1A inhibited NSCLC cell proliferation, migration, and invasion and promoted apoptosis and cisplatin sensitivity. Likewise, circ_PIP5K1A downregulation inhibited tumor growth. 33570734 circGLIS3 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-644a/PTBP1) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//Invasion Assay//IF In current study, circGLIS3 was found to be highly expressed in NSCLC tissues and cell lines and high circGLIS3 level was correlated to malignant characteristics and poor prognosis of NSCLC. In conclusion, CircGLIS3 functions as an oncogene via sponging multiple tumor-suppressive miRNAs in NSCLC. A circGLIS3/miR-644a/PTBP1 positive feedback loop exists in the tumorigenesis and development of NSCLC. In current study, circGLIS3 was found to be highly expressed in NSCLC tissues and cell lines and high circGLIS3 level was correlated to malignant characteristics and poor prognosis of NSCLC. Yes Functional experiments suggested that circGLIS3 promoted proliferation, migration and invasion and arrested apoptosis of NSCLC cells in vitro.CircGLIS3 also participated in the in vivo process by accelerate NSCLC tumor growth and metastasis. 33520363 circSLC8A1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-106b-5p /FOXJ3 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay CircSLC8A1 was found to be downregulated in NSCLC tissues and cell lines.Further investigations shown that circSLC8A1 was able to bind to miR-106b-5p as well as inhibit the expression of miR-106b-5p in NSCLC cells. Furthermore, we found that forkhead box J3 (FOXJ3) to be a target gene of miR-106b-5p in NSCLC cells. Knockdown of FOXJ3 reversed the inhibitory effects of miR-106b-5p inhibitor on cell proliferation and invasion. Yes Overexpression of circSLC8A1 significantly inhibited the proliferation and invasion of NSCLC cells. 34724864 hsa_circ_0002360 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression(highly expressed) Western Blot//qRT-PCR//Luciferase Report Assay//BrdU//Transwell Assay We found that circ_0002360 expression was raised in NSCLC tissues. High circ_0002360 expression predicted a short overall survival time for NSCLC patients. MiR-127-5p, miR-145-5p, miR-585-3p, and miR-758-3p were the targets of circ_0002360, and circ_0002360 could regulate MMP16 expression by competitively binding with the above miRNAs. We found that circ_0002360 expression was raised in NSCLC tissues. High circ_0002360 expression predicted a short overall survival time for NSCLC patients. Yes Circ_0002360 overexpression promoted NSCLC cell proliferative, migrative, and invasive abilities, and circ_0002360 depletion worked oppositely. 34747300 circCCND1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer cells and patients Interaction(miR-187-3p/FGF9 ) qRT-PCR We observed that circCCND1 was significantly upregulated in lung cancer cells and patients. Yes circCCND1 knockdown attenuated cell proliferation and induced apoptosis under cisplatin treatment. Mechanistically, circCCND1 interacted with miR-187-3p to regulate reactive oxygen species and FGF9 in NSCLC cells. Finally, miR-187-3p was demonstrated to rescue circCCND1 knockdown-modulated chemoresistance of NSCLC cells. 33733860 F-circEA1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NCI-H3122 cells  Interaction(ALK) Western Blot//Migration Assay//CCK8//qRT-PCR//FISH//Flow Cytometry//Cell Viability Assay//IHC//Invasion Assay//Transwell Assay Our study confirmed the existence of fusion circEA1 (F-circEA1) in NCI-H3122 cells (carrying the EML4-ALK1 gene), F-circEA1 was expressed both in the cytoplasm and nucleus as determined by fluorescence in situ hybridization (FISH) and Sanger sequencing. Yes CCK8 and transwell assays showed that F-circEA1 was beneficial to cell proliferation, metastasis, and invasion. Overexpression of F-circEA1 can also promote cell proliferation, migration and invasion in A549 and SPCA1 cells (non-small cell lung cancer cell line not carrying the EML4-ALK1 gene). 34633654 hsa_circ_0008594 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung 10 NSCLC tissues and 10 adjacent tissues Interaction(miR-760) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay A total of 455 dysregulated circRNAs in NSCLC tissues versus adjacent tissues and 353 dysregulated circRNAs in NSCLC tissues with LNM versus those without LNM were discovered. Yes Subsequent experiments showed that circ_0008594 promoted H23 and H460 cell proliferation and invasion but affected stemness less and negatively regulated miR-760 via direct binding.  34858831 circLARP4 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell lines (including NCI-H1299, NCI-H522, NCI-H23, NCI-H358, and NCI-H1650) regulation[sponging miR-21-5p] CCK8//qRT-PCR//Luciferase Report Assay Circ-LARP4 expression was decreased in NSCLC cell lines (including NCI-H1299, NCI-H522, NCI-H23, NCI-H358, and NCI-H1650) compared with human normal lung epithelial cell line. Circ-LARP4 is decreased and suppresses cell proliferation while promoted apoptosis by sponging miR-21-5p in NSCLC. Yes Circ-LARP4 overexpression inhibited cell proliferation while promoted apoptosis in NCI-H1650 cells, whereas circ-LARP4 knockdown increased cell proliferation while decreased apoptosis in NCI-H1299 cells. 32614609 circCDYL CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues, plasma, and cell lines. Interaction(miR-185-5p) IHC//Western Blot//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay The decreased level of circCDYL was observed in NSCLC patients’ tissues and plasma, which was also downregulated in NSCLC cell lines. Yes Forced expression of circCDYL inhibited cell viability, proliferation and induced apoptosis in A549 cells. Luciferase assay verified that circCDYL could bind with miR-185-5p and confirmed that TNRC6A was a downstream target of miR-185-5p. Overexpression of miR-185-5p or silencing of TNRC6A could inhibit the anti-tumor effect of circCDYL in A549 cells via regulating the ERK1/2 signal. 33531835 circTUBA1C CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues interaction[sponging miR-143-3p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay In the present study, we found that the expression of circTUBA1C was significantly upregulated in NSCLC tissues.Taken together, these findings indicated the important role of circTUBA1C/miR-143-3p axis in NSCLC, which may provide a potential target for NSCLC therapy. Yes The loss-of function assays suggested that circTUBA1C deficiency notably hampered cell proliferation as well as accelerated cell apoptosis in NSCLC. 32599139 hsa_circ_0000353 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[ miR-411-5p,FOXO1] Western Blot//CCK8//qRT-PCR//BrdU//Colony Formation Assay//Transwell Assay Circ_0000353 was significantly down-regulated in NSCLC tissues and cell lines,Circ_0000353 repressed the proliferation, migration, and invasion of NSCLC cells via inhibition of miR-411-5p and up-regulation of FOXO1. Circ_0000353 was significantly down-regulated in NSCLC tissues and cell lines, and the decreased expression was significantly linked to the increased clinical stage, larger tumor volume, and metastasis. Yes The circ_0000353 over-expression restrained the proliferation, migration, and invasion of NSCLC cells in vitro. 32568175 hsa_circ_0000284 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-377-3p-mediated PD-L1 promotion] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay As for the biological characterization, circ_0000284 was highly stable and localized in the cytoplasm.Thus, our results unraveled that circ_0000284 facilitated the progression of NSCLC by up-regulating the PD-L1 expression as a competing endogenous RNA (ceRNA) of miR-377, possibly developing a different perspective in understanding the molecular pathogenesis of NSCLC. Circ_0000284 was up-regulated in NSCLC and could predict poor prognosis of NSCLC patients. Yes Both in vitro and in vivo, down-regulation of circ_0000284 refrained tumorigenesis of NSCLC. 32550825 hsa_circ_0072088 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-377-5p/NOVA2 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Colony Formation Assay//Transwell Assay GSE101586 dataset and the analysis of tissue specimens showed that circ_0072088 was aberrantly upregulated in tumor tissues of lung cancer and NSCLC.Circ_0072088 facilitated the proliferation and metastasis of NSCLC cells through upregulating NOVA2 via functioning as a competitive endogenous RNA (ceRNA) for miR-377-5p. Yes Circ_0072088 interference caused marked suppression on the proliferation and motility of NSCLC cells. 32524752 hsa_circ_0109320 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues or cells regulation[MiR-595/E2F7 Axis] qRT-PCR//Transwell Assay//Western Blot The results of present study indicated that circ_0109320 expression in NSCLC patients was upregulated significantly in tumor tissues compared with tissues adjacent to carcinoma. Circ_0109320/miR-595/E2F2 axis may exert a pivotal role in the pathological mechanism of NSCLC progression, and it has potential application in the future treatment of NSCLC. Upregulated circ_0109320 level was significantly associated with TNM stages as well as lymph node metastasis of NSCLC. Yes Moreover, downregulation of circ_0109320 attenuated proliferation and invasion while promoting apoptosis in NSCLC cells. 32508344 circSEC31A CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[miR-520a-5p/GOT-2 axis] CCK8//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay In this study, we found that hsa_circ_0001421 (circ-SEC31A) was upregulated in NSCLC tissues and cell lines. Mechanistically, we demonstrated that silencing circ-SEC31A downregulated GOT-2 expression by relieving the sponging effect of miR-520a-5p, which resulted in significantly reduced malate-aspartate metabolism in NSCLC cells. Increased circ-SEC31A expression in NSCLC was significantly correlated with malignant characteristics and served as an independent risk factor for the post-surgical overall survival of NSCLC patients. Yes Reduced circ-SEC31A expression in NSCLC decreased tumor cell proliferation, migration, invasion, and malate-aspartate metabolism. 32499446 hsa_circ_100565 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues interaction[HMGA2 ,miR-506-3p] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Circ_100565 was upregulated in NSCLC, and its high expression was positively associated with the poor overall survival of NSCLC patients.Circ_100565 increased HMGA2 expression to promote proliferation, migration and invasion in NSCLC via absorbing miR-506-3p. Circ_100565 was upregulated in NSCLC, and its high expression was positively associated with the poor overall survival of NSCLC patients. Yes Silencing of circ_100565 suppressed the proliferation, migration and invasion of NSCLC cells in vitro and reduced the tumor growth of NSCLC in vivo. 32425695 circPSMC3 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-182-5p/NME2 Axis] qRT-PCR//Wound Healing Assay//Luciferase Report Assay Compared with adjacent normal tissues, the expression of circPSMC3 in NSCLC tissues was decreased. CircPSMC3 inhibits the invasion and migration of NSCLC cells through the miR-182-5p/NME2 signaling pathway. Lower circPSMC3 expression was closely associated with lymph node metastasis and higher TNM stage in NSCLC patients. Yes Biological function analysis suggested that circPSMC3 inhibits the invasion and migration of H1299 cells through upregulating the expression of NME2. 32386284 hsa_circ_001010 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells interaction[miR-5112,CDK4] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Results showed that the expressions of circRNA_001010 and CDK4 were upregulated in human NSCLC tissues and cells.The bioinformatics prediction and Luciferase assay demonstrated that by sponging with miR-5112, circRNA_001010 can serve as a ceRNA for miR-5112 to further regulate the expression of CDK4. Yes qRT-PCR and CCK-8 assay showed that circRNA_001010 expression is associated with the proliferation of NSCLC cells, and that upregulated circRNA_001010 contributed to cell proliferation of A549. Transwell assay showed that circRNA_001010 was associated with the migration ability of tumor cells, and that increased expression of circRNA_001010 promoted the migration and invasion of NSCLC cells. 32373963 hsa_circ_0087862 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patients regulation[miR-1253/RAB3D Axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Transwell Assay hsa_circ_0087862 was significantly up-regulated in NSCLC patients, which was associated with poor prognosis (P < 0.05). hsa_circ_0087862 acted as an oncogene in NSCLC by targeting miR-1253/RAB3D. hsa_circ_0087862 was significantly up-regulated in NSCLC patients, which was associated with poor prognosis (P < 0.05). Yes hsa_circ_0087862 down-regulation prominently weakened NSCLC cells viability, migration, invasion and enhanced apoptosis (P < 0.01). hsa_circ_0087862 overexpression exhibited the opposite results in NSCLC cells. 32308420 circBIRC6 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and NSCLC cells interaction[sponging microRNA-145] qRT-PCR We found that circBIRC6 was upregulated in primary human NSCLC tissues and NSCLC cells, whereas its potential target, miR-145, was downregulated. From our data we conclude that circBIRC6 overexpression promotes NSCLC cell progression, possibly by sponging miR-145. Yes In A549 NSCLC cells and primary human NSCLC cells, shRNA-induced silencing of circBIRC6 potently inhibited their growth, proliferation, migration and invasion. 32297303 circCCDC66 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells regulation[miR-33a-5p/KPNA4 axis] ChIP//Western Blot//Tunel//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In this study, circCCDC66 in NSCLC cells was highly expressed. Briefly, STAT3-induced circCCDC66 upregulation accelerates NSCLC progression via miR-33a-5p/KPNA4 axis, suggesting circCCDC66 as a promising biomarker in NSCLC treatment. Yes Downregulation of circCCDC66 impaired cell proliferation, migration and invasion whereas boosted cell apoptosis in NSCLC. 32151944 hsa_circ_103762 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell Expression[highly expressed] CCK8//qRT-PCR In our study, circRNA_103762 expression was upregulated in NSCLC tissues and cell. Yes Knockdown of circRNA_103762 can inhibited cell proliferation, migration and invasion in NSCLC. 32118311 circNT5E CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells interaction[sponging microRNA-134] qRT-PCR//RNA Pull-Down We show that circNT5E levels are significantly elevated in human NSCLC tissues and cells, correlating with downregulation of its potential targets, miR-134, miR-422a and miR-338. In A549 and primary NSCLC cells, circNT5E shRNA inhibited cancer cell growth, proliferation and migration, whiling inducing apoptosis activation. Importantly, circNT5E shRNA was ineffective in miR-134-overexpressed A549 cells. Collectively, circNT5E promotes human NSCLC cell progression possibly by sponging miR-134. Yes We show that circNT5E levels are significantly elevated in human NSCLC tissues and cells, correlating with downregulation of its potential targets, miR-134, miR-422a and miR-338. In A549 and primary NSCLC cells, circNT5E shRNA inhibited cancer cell growth, proliferation and migration, whiling inducing apoptosis activation.Conversely, ectopic circNT5E overexpression promoted A549 cell progression in vitro. 32096481 hsa_circ_0014130 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues interaction[miR-136-5p,BCL2] qRT-PCR//Luciferase Report Assay//Western Blot "The level of hsa_circ_0014130 was significantly upregulated in NSCLC tissues. In addition, hsa_circ_0014130 functions as a tumor promoter in NSCLC to promote tumor growth through upregulating Bcl-2 partially via ""sponging"" miR-136-5p." Yes Downregulation of hsa_circ_0014130 markedly inhibited the proliferation and invasion of A549 cells via inducing apoptosis. In addition, downregulation of hsa_circ_0014130 inhibited the tumorigenesis of subcutaneous A549 xenograft in mice in vivo. 32060230 circGFRA1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[circGFRA-miR-188-3p-PI3K/AKT regulatory pathway] CCK8//qRT-PCR//Colony Formation Assay//RIP The expression of circGFRA1 and miR-188-3p was detected in NSCLC tissues by RT-qPCR and it was found that circGFRA1 was highly expressed and miR-183-3p was lowly expressed in NSCLC tissues. Our study elaborated a novel circGFRA-miR-188-3p-PI3K/AKT regulatory pathway, providing a potential diagnostic biomarker and therapeutic target for NSCLC. Yes Overexpression of cirGFRA1 enhanced NSCLC progression while miR-188-3p overexpression inhibited it by CCK8 and colony formation analysis. In vivo tumor xenograft model, circGFRA1 and miR-188-3p synergistically regulated the proliferation of NSCLC tumors. 32021297 circCDR1as CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-219a-5p/SOX5 axis] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircCDR1as expression was elevated in NSCLC tissues and cells in comparison to the matched controls.Knockdown of circCDR1as inhibited the progression of NSCLC by decreasing cell viability, migration and invasion and increasing apoptosis by upregulating miR-219a-5p and downregulating SOX5. Yes Interference of circCDR1as led to obvious inhibition of cell viability, migration and invasion and increase of apoptosis in NSCLC cells. 31917898 hsa_circ_0014130 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-142-5p/IGF-1 Axis] RNA Pull-Down//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay Circ_0014130 was abnormally highly expressed in NSCLC tissues and cells.Our results indicated that the silencing circ_0014130 inhibited NSCLC cell proliferation and promoted cell apoptosis by upregulating miR-142-5p and downregulating IGF-1 expression. Yes After shRNA interfering circ_0014130 of NSCLC cells H1299 and A549, the NSCLC cell proliferation was inhibited and the cell apoptosis was promoted. 31916848 hsa_circ_0020123 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC specimens and adjacent normal samples Interaction[miR-488-3p;ADAM9 ] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot We found circ_0020123 was higher in NSCLC samples than the normal counterparts (Fig. 1B). In addition, similar results were found in NSCLC cells compared with 16HBE (Fig. 1C). For the mechanism exploration, circ_0020123 could sponge miR-488-3p to release its inhibition on ADAM9 expression. Moreover, the functional role of circ_0020123 is partly dependent on its regulation of ADAM9 proved by rescue assays. Taken together, our findings provide the possibility that circ_0020123 may be a new target for NSCLC prognosis prediction and therapy. As Table 1 demonstrated, TNM stage (P = 0.037) and lymph node invasion (P = 0.029) were two circ_0020123 associated clinical factors in the patients with NSCLC. Other clinical features such as smoking status and differentiation grade were not linked to circ_0020123 expression. Kaplan-Meier analysis showed that high level of circ_0020123 was obviously in connection with a decrease in patients’ overall survival (Fig. 1D). Further cox regression analysis demonstrated the independent prognostic role of circ_0020123 in the patients with NSCLC (P = 0.031, Table 2). Yes Functionally, silencing of circ_0020123 distinctly sExpression[Expression[up-expression]-expression]pressed the growth, migration and invasion and inhibited the apoptosis of A549 cells. On the contrary, when circ_0020123 expression was ectopically expressed, the above effects were significantly strengthened in H1299 cell line. 31153639 circPRMT5 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cancer and adjacent normal tissues,cell lines(HBE, NSCLC,A549, 95-D, HCC827, H1299,SK-MES-1) Regulation[miR-377/382/498-EZH2 axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot As shown in Fig. 1A, circ-PRMT5 was significantly overexpressed in NSCLC tissues in comparison to para-carcinoma normal tissues. Also, the uniformly up-regulated circ-PRMT5 was observed in five NSCLC cell lines as compared with normal human bronchial epithelial HBE cells Overall, our data indicate that circ-PRMT5 is an oncogenic circRNA in NSCLC that can promote the growth of NSCLC via regulation of miR-377/382/498-EZH2 axis. Yes Stable knockdown of circ-PRMT5 dramatically weakened the proliferative capacities of NSCLC cells both in vitro and in vivo. 31479715 hsa_circ_100146 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC and matched paracancerous tissues,cell lines(16HBE,A549, H446, H1299, 95-D,H460,HEK-293T) Expression[highly expressed] Western Blot//qRT-PCR//FISH//Luciferase Report Assay//RNA-seq Data from the current investigation showed that circRNA 100146 is highly expressed in non-small cell lung cancer (NSCLC) cell lines and the chemically induced malignant transformed bronchial cell line, 16HBE-T, as well as 40 paired tissue samples of NSCLC. Yes Suppression of circRNA 100146 inhibited the proliferation and invasion of cells and promoted apoptosis. 30665425 circWHSC1 CircRNA Homo sapiens Breast Neoplasms BC tissues Interaction(miR-195-5p/FASN/AMPK/mTOR Axis ) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU//IHC//Transwell Assay As shown by the result, circWHSC1 was up-regulated in BC tissues versus adjacent non-tumor tissues.Collectively, CircWHSC1 acted as an oncogene to expedite BC evolvement by modulating the miR-195-5p/FASN/AMPK/mTOR pathway. circWHSC1 overexpression was correlated with higher tumor stages, lymphatic metastasis and worse survival of BC patients. Yes Functionally, overexpressing circWHSC1 amplified proliferation, migration and invasion of BC cell lines and boosted xenograft tumor growth in nude mice. 35070947 hsa_circ_0084927 CircRNA Homo sapiens Breast Neoplasms BC tissues and cell Interaction(miR-142-3p/ERC1 pathway) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay High levels of circ_0084927 and ERC1 and low levels of miR-142-3p were detected in the BC tissues and cells. miR-142-3p is the target of circ_0084927. Overexpression of miR-142-3p could inhibit BC cell proliferation, colony formation, and cell invasion and induce apoptosis of the BC cells (all P<0.05), and the effects of miR-142-3p knockout on the BC cells could be reversed by silencing circ_0084927. miR-142-3p could target ERC1. Both ERC1 silencing and circ_0084927 knockout in the BC cells could achieve the tumor-suppressing effect, and this effect could be more remarkable under simultaneous ERC1 silencing and circ_0084927 knockout (all P<0.05). Yes Knockdown of circ_0084927 promoted apoptosis and inhibited proliferation, colony formation, and invasion of BC cells (all P<0.05), whereas overexpression of circ_0084927 in the BC cells achieved the opposite effects. 34150003 hsa_circ_0001667 CircRNA Homo sapiens Breast Neoplasms cell lines Interaction(miR-4458/NCOA3 ) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0001667 knockdown inhibited MCF-7/ADM and MDA-MB-231/ADM cell proliferation, migration, invasion and ADM resistance. MiR-4458 was a target of circ_0001667, and its expression was decreased in ADM-resistant tumor tissues and cells. MiR-4458 inhibition reversed the effects of circ_0001667 knockdown. In depth, NCOA3 was a target of circ_0001667, and circ_0001667 knockdown weakened NCOA3 expression by releasing miR-4458. Yes Circ_0001667 knockdown inhibited MCF-7/ADM and MDA-MB-231/ADM cell proliferation, migration, invasion and ADM resistance. 34227151 circYY1 CircRNA Homo sapiens Breast Neoplasms BC TISSUES Interaction(miR-769-3p/YY1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Transwell Assay CircYY1 and YY1 were upregulated in BC, while miR-769-3p had an opposing result. CircYY1 acted as a sponge for miR-769-3p, which targeted YY1. CircYY1 sponged miR-769-3p to modulate YY1 expression. Both miR-769-3p inhibition and YY1 upregulation antagonized circYY1 silencing-mediated influence on malignancy and glycolysis of BC cells. Also, BC patients with high circYY1 expression had a poor prognosis. Yes Downregulation of circYY1 decreased xenograft tumor growth in vivo. Both circYY1 inhibition and miR-769-3p elevation constrained BC cell viability, colony formation, migration, invasion, and glycolysis in vitro. 33603460 circNOL10 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation(PDCD4) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay Circ-NOL10 is downregulated in breast cancer and associated with aggressive characteristics and shorter survival time. Furthermore, circ-NOL10 binds multiple miRNAs to alleviate carcinogenesis by regulating PDCD4. CASC3 and metadherin (MTDH) can bind directly to circ-NOL10 with characterized motifs. Accordingly, ectopic expression or depletion of CASC3 or MTDH leads to circ-NOL10 expression changes, suggesting that these two RBPs modulate circ-NOL10 in cancer cells. Circ-NOL10 is downregulated in breast cancer and associated with aggressive characteristics and shorter survival time. Yes Upregulation of circ-NOL10 promotes apoptosis, decreases proliferation, and inhibits invasion and migration. 34729247 hsa_circ_0001598 CircRNA Homo sapiens Breast Neoplasms BC tissue Interaction(miR-1184/PD-L1 signaling) qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Western Blot We observed upregulation of circ_0001598 in BC tissues, especially in trastuzumab-resistant BC samples.We further identified that miR-1184 is a functional target of circ_0001598. Moreover, it was found that programmed death-ligand 1 (PD-L1) was a direct target of miR-1184. Yes The oncogenic effects of circ_0001598 in promoting BC cell growth, trastuzumab-resistance, PD-L1 expression, and escaping of CD8 T cell killing were abolished after the restoration of miR-1184. 34559381 hsa_circ_0000517 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction( miR-326) qRT-PCR//Luciferase Report Assay//Western Blot Hsa_circ_0000517 was upregulated in breast cancer tissues and cells. Hsa_circ_0000517 acted as a sponge of miR-326 to suppress its expression. miR-326 inhibition abolished the effects of hsa_circ_0000517 knockdown on the malignant behaviors of breast cancer cells. Yes Hsa_circ_0000517 knockdown inhibited cell proliferation, colony formation ability, and invasion and triggered apoptosis in breast cancer cells. 34619576 circABCB10 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-223-3p/PFN axis ) qRT-PCR//Luciferase Report Assay//Western Blot CircABCB10 and PFN2 were elevated, while miR-223-3p was reduced in BC tissues and cells. CircABCB10 sponged miR-223-3p, and PFN2 was a target of miR-223-3p in BC cells. Besides, circABCB10 knockdown declined PFN2 in BC cells via miR-223-3p. Yes CircABCB10 silencing inhibited cell proliferation, glycolysis, colony formation, and decreased IR resistance in BC cells by modulating miR-223-3p. Meanwhile, circABCB10 depletion restrained xenograft tumor growth in vivo. Also, miR-223-3p overexpression refrained cell proliferation, glycolysis, and colony formation while improving IR sensitivity in BC cells by regulating PFN2. 32522014 hsa_circ_0001982 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells under hypoxia Interaction(miR-1287-5p/MUC19 axis) Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay The levels of circ_0001982 and MUC19 were upregulated, while miR-1287-5p was downregulated in BC tissues and cells under hypoxia. Mechanistic studies discovered that circ_0001982 could act as a sponge for miR-1287-5p to enhance MUC19 expression in BC cells. In addition, circ_0001982 silencing reduced xenograft tumor growth by regulating miR-1287-5p/MUC19 axis. Yes Knockdown of circ_0001982 hindered glycolysis, cell viability, migration, and invasion of BC cells under hypoxia. 34082777 hsa_circ_0068631 CircRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction(EIF4A3/c-Myc axis) In Vivo Experiment//RNA Pull-Down//IHC//Transwell Assay//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//FISH//RIP//MTT//Colony Formation Assay//IF In this study, we demonstrate that hsa_circ_0068631, a circRNA generated from the transferrin receptor (TFRC), is upregulated in BC tissues and cell lines. Mechanistically, an RNA pull-down assay and RNA immunoprecipitation assay revealed that eukaryotic translation initiation factor 4A3 (EIF4A3) could bind to hsa_circ_0068631 and c-Myc mRNA. Additionally, the expression of hsa_circ_0068631 was positively correlated with c-Myc, and the upregulation of hsa_circ_0068631 was a crucial factor for the dysregulation of c-Myc. Through an actinomycin D assay, we confirmed that the mRNA stability of c-Myc was influenced by hsa_circ_0068631 and EIF4A3. Furthermore, hsa_circ_0068631 could recruit EIF4A3 to increase c-Myc mRNA stability. Yes Knockdown of hsa_circ_0068631 inhibited the proliferation and migration of BC cells in vitro and in vivo. 34513299 circKLHL24 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(miR-1204/ ALX4 Network) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay circKLHL24 and ALX4 were downregulated, while miR-1204 was upregulated in breast cancer tissues and cells. miR-1204 bound to ALX4, and circKLHL24 sponged miR-1204 to upregulate ALX4. Cell viability, colony formation, migration/invasion, and glycolysis progression suppressed by miR-1204 deficiency were recovered by ALX4 knockdown. Besides, circKLHL24 blocked tumor growth in vivo by regulating miR-1204 and ALX4. Yes circKLHL24 overexpression blocked cell viability, colony formation, migration/invasion, and glycolysis progression. circKLHL24 competitively targeted miR-1204, and miR-1204 reintroduction reversed the effects of circKLHL24 restoration. 33781094 hsa_circ_0088088 CircRNA Homo sapiens Breast Neoplasms tumor tissues and cells Interaction(miR-135-5p) RNA Pull-Down//Western Blot//RIP//Luciferase Report Assay//Transwell Assay hsa_circ_0088088 was upregulated in the tumor tissues and cells, and higher expression presented an unfavorable prognosis. EIF4A3 was found to positively regulate hsa_circ_0088088. Furthermore, we confirmed that hsa_circ_0088088 sponges miR-135-5p and directly targets miR-135-5p with respect to the cell growth and metastasis in MDA-MB-231 cells. hsa_circ_0088088 was upregulated in the tumor tissues and cells, and higher expression presented an unfavorable prognosis. Yes hsa_circ_0088088 overexpression promoted cell growth and metastasis in MDA-MB-231 cells. 34463003 hsa_circ_0069718 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-590-5p/NFIB axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ_0069718 was up-regulated in BC tissues and cells.Mechanistically, circ_0069718 directly targeted miR-590-5p to up-regulate its target NFIB. Rescue experiments showed that miR-590-5p inhibition reversed the inhibitory effects of circ_0069718 knockdown on BC cell-aggressive oncogenic phenotypes; moreover, miR-590-5p re-expression restrained BC cell proliferation and mobility, which were abolished by NFIB up-regulation. Yes Knockdown of circ_0069718 suppressed BC cell apoptosis, migration, and invasion in vitro effectively.Besides that, circ_0069718 silencing hindered tumor growth via miR-590-5p/NFIB axis in vivo. 34632534 circRPPH1 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-328-3p/HMGA2 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RNA-seq//migration assay//Luciferase Report Assay//Invasion Assay Circ-RPPH1 expression was elevated and miR-328-3p was decreased in BC tissues and cells. Yes Circ-RPPH1 knockdown or miR-328-3p re-expression suppressed cell proliferation, migration, invasion and glycolysis but induced apoptosis in BC in vitro. 34593318 circARL8B CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-653-5p/HMGA2 Axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay CircARL8B was increased in BC tissues and cells. CircARL8B silencing inhibited cell viability, migration, invasion and fatty acid metabolism in BC cells in vitro and blocked tumor growth in vivo. MiR-653-5p was identified as the target of circARL8B and miR-653-5p was negatively modulated by circARL8B. The suppressive role of circARL8B silencing in BC cell progression was abolished by miR-653-5p downregulation. Moreover, HMGA2 was the target gene of miR-653-5p. HMGA2 overexpression abrogated the effect of miR-653-5p on BC cell development. In addition, circARL8B knockdown might block PGE2/PI3K/AKT/GSK-3β/Wnt/β-catenin pathway. Silencing of circARL8B inhibited cell viability, migration, invasion and fatty acid metabolism via miR-653-5p/HMGA2 axis in BC. Yes In addition, circARL8B knockdown might block PGE2/PI3K/AKT/GSK-3β/Wnt/β-catenin pathway.Silencing of circARL8B inhibited cell viability, migration, invasion and fatty acid metabolism via miR-653-5p/HMGA2 axis in BC. 34050452 hsa_circ_0005273 CircRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction(miR-200a-3p/YAP1 axis ) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//FISH//MTT//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay Hsa_circ_0005273 is over-expressed in BC tissues and cell lines, whereas miR-200a-3p expression is repressed.Importantly, hsa_circ_0005273 upregulated YAP1 expression and inactivated Hippo pathway via sponging miR-200a-3p to promote BC progression. Yes Depletion of hsa_circ_0005273 inhibited the progression of BC cells in vitro and in vivo, while overexpression of hsa_circ_0005273 exhibited the opposite effect. 33436041 circACTN4 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(FUBP1 ) RNA Pull-Down//ChIP//Western Blot//ISH//Wound Healing Assay//Co-IP//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Cycle Assay//IHC//Invasion Assay//IF CircACTN4 was significantly upregulated in breast cancer tissues and cells, its expression was correlated with clinical stage and poor prognosis of patients with BC. Further mechanistic research proved that circACTN4 could competitively bind to far upstream element binding protein 1 (FUBP1) to prevent the combination between FUBP1 and FIR, thereby activating MYC transcription and facilitating tumor progression of breast cancer. Furthermore, we found that upstream transcription factor 2 (USF2) might promote the biogenesis of circACTN4. CircACTN4 was significantly upregulated in breast cancer tissues and cells, its expression was correlated with clinical stage and poor prognosis of patients with BC. Yes Ectopic expression of circACTN4 strikingly facilitated the growth, invasion, and metastasis of breast cancer cells in vitro and in vivo.Whereas knockdown of circACTN4 revealed opposite roles. 34116677 hsa_circ_001569 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[Wnt/β-catenin pathway] CCK8//qRT-PCR//Colony Formation Assay//Western Blot In the present study, it was demonstrated that expression levels of circ_001569 were significantly increased in NSCLC tissues compared with in adjacent normal tissues.Therefore, the results indicated that circ_001569 promoted cell proliferation by regulating the Wnt/β-catenin pathway in NSCLC, and circ_001569 may be a potential target of NSCLC treatment. Increased circ_001569 expression was closely associated with tumor differentiation, lymph node metastasis and Tumor-Node-Metastasis classification in NSCLC. Patients that exhibited higher circ_001569 expression demonstrated a poorer survival outcome compared with patients with lower circ_001569 expression. Yes Functional assay results indicated that the knockdown of circ_001569 inhibited the cell proliferation ability of NSCLC in vitro. 29928432 circMMP11 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-625-5p/ZEB2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay We found that circMMP11 and ZEB2 were overexpressed in BC tissues and cells compared with controls.Additionally, miR-625-5p, interacted with ZEB2, was a target of circMMP11 in BC cells. CircMMP11 regulated the expression of ZEB2 by targeting miR-625-5p. Knockdown of circMMP11-mediated effects on BC cells could be abolished by overexpression of ZEB2. Yes The suppression of circMMP11 or ZEB2 repressed proliferation, migration, and invasion while induced apoptosis of BC cells. Consistently, silencing of circMMP11 impeded the tumor growth in vivo. 33632213 circRPPH1 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-542-3p/ARHGAP1 Pathway) Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay pregulation of circ_RPPH1 and ARHGAP1, and downregulation of miR-542-3p were detected in BC tissues and cells. circ_RPPH1 sponged miR-542-3p to upregulate ARHGAP1 expression, thereby affecting BC progression. Yes circ_RPPH1 knockdown or miR-542-3p introduction inhibited BC cell proliferation and metastasis, while promoted apoptosis in vitro. circ_RPPH1 sponged miR-542-3p to upregulate ARHGAP1 expression, thereby affecting BC progression. Moreover, depletion of circ_RPPH1 suppressed tumor growth in vivo. 34402683 circDNMT1 CircRNA Homo sapiens Breast Neoplasms The paired tumor and paracancer tissues (n = 41) Interaction(miR-485-3p/ZEB1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay Circ-DNMT1 and ZEB1 levels were upregulated in breast cancer, and miR-485-3p was downregulated. MiR-485-3p was negatively regulated by circ-DNMT1, and miR-485-3p knockdown mitigated the effect of circ-DNMT1 silence on breast cancer development. ZEB1 was targeted via miR-485-3p, miR-485-3p overexpression repressed cell colony formation, migration, and invasion and triggered apoptosis by decreasing ZEB1. Yes Circ-DNMT1 knockdown restrained cell colony formation, migration, and invasion and increased apoptosis. MiR-485-3p was negatively regulated by circ-DNMT1, and miR-485-3p knockdown mitigated the effect of circ-DNMT1 silence on breast cancer development. ZEB1 was targeted via miR-485-3p, miR-485-3p overexpression repressed cell colony formation, migration, and invasion and triggered apoptosis by decreasing ZEB1. Circ-DNMT1 silence reduced ZEB1 expression via regulating miR-485-3p. Circ-DNMT1 knockdown reduced xenograft tumor growth. 33403756 circIKBKB CircRNA Homo sapiens Breast Neoplasms bone-metastatic BC tissues Regulation(NF-κB/bone remodeling factors signaling) RNA-seq We identified that a novel circRNA, circIKBKB, was upregulated significantly in bone-metastatic BC tissues. Mechanically, circIKBKB activated NF-κB pathway via promoting IKKβ-mediated IκBα phosphorylation, inhibiting IκBα feedback loop and facilitating NF-κB to the promoters of multiple bone remodeling factors. Moreover, EIF4A3, acted acting as a pre-mRNA splicing factor, promoted cyclization of circIKBKB by directly binding to the circIKBKB flanking region. Yes Overexpressing circIKBKB enhanced the capability of BC cells to induce formation of bone pre-metastatic niche dramatically by promoting osteoclastogenesis in vivo and in vitro. 34325714 circHIPK3 CircRNA Homo sapiens Breast Neoplasms Bca tissues Interaction( miR-326) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Transwell Assay In BCa, the expression of circHIPK3 was up-regulated and that of miR-326 was down-regulated. MiR-326 was the direct target of circHIPK3, and was inversely correlated with circHIPK3 expression. Yes CircHIPK3 knockdown inhibited the cell proliferation, invasion, and migration. MiR-326 was the direct target of circHIPK3, and was inversely correlated with circHIPK3 expression. 34152928 hsa_circ_0008673 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(miR-153-3p/CFL2 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0008673 and CFL2 expressions were upregulated, while miR-153-3p expression was downregulated in breast cancer tissues and cells compared with adjacent normal breast tissues and cells, respectively. circ_0008673 served as a sponge of miR-153-3p. And circ_0008673 was proved to regulate breast cancer cell malignancy by sponging miR-153-3p. MiR-153-3p was found to modulate breast cancer cell carcinogenesis via targeting CFL2. Yes Circ_0008673 overexpression promoted cell proliferation, migration and invasion, and repressed cell apoptosis, while circ_0008673 silencing had opposite effects. 34324029 circMETTL3 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(miR-31-5p/CDK1 axis. ) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Herein, we report circMETTL3, which has not been explored in breast cancer, and it is markedly upregulated in breast cancer. Mechanism investigation showed that circMETTL3 might act as a competing endogenous RNA (ceRNA) of miR-31-5p and upregulate its target cyclin-dependent kinases (CDK1). Moreover, m6A modification of circMETTL3 might affect its expression. Yes Moreover, we uncovered that circMETTL3 could facilitate cell proliferation, migration and invasion in breast cancer. 33867838 circNOL10 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-767-5p / SOCS2/JAK/STAT signaling) IHC//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay CircNOL10 was down-regulated in BC tissues and cells. CircNOL10 repressed BC development via inactivation of JAK2/STAT5 signaling by regulating miR-767-5p/SOCS2 axis. Low expression of circNOL10 was associated with larger tumor size, advanced TNM stage, lymph node metastasis and unfavorable prognosis. Yes Overexpression of circNOL10 inhibited cell proliferation, migration, invasion and EMT in vitro and slowed xenograft tumor growth in vivo. 33397365 hsa_circ_0025202 CircRNA Homo sapiens Breast Neoplasms cancer tissues Interaction(miR-182-5p/FOXO3a Axis ) Western Blot//Migration Assay//RIP//Luciferase Report Assay//Colony Formation Assay hsa_circ_0025202, a circRNA that was significantly downregulated, was selected for further investigation. Using a large cohort of clinical specimens, we found that hsa_circ_0025202 exhibited low expression in cancer tissues and was negatively correlated with lymphatic metastasis and histological grade. Bioinformatics and luciferase reporter assays verified that hsa_circ_0025202 could act as a miRNA sponge for miR-182-5p and further regulate the expression and activity of FOXO3a. Yes Gain- and loss-of-function assays indicated that hsa_circ_0025202 could inhibit cell proliferation, colony formation, and migration and increase cell apoptosis and sensitivity to tamoxifen. 31153828 hsa_circ_0043278 CircRNA Homo sapiens Breast Neoplasms BC cell lines Interaction(miR-455-3p/EI24 signalling pathway) Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Invasion Assay sa_circ_0043278 was downregulated in BC cell lines. Hsa_circ_0043278 expression was negatively correlated with that of miR-455-3p. In addition, mechanistic investigation proved that hsa_circ_0043278 directly bound to miR-455-3p and regulated EI24 and NF-κB expression in BC cells. Yes Furthermore, overexpression of hsa_circ_0043278 notably decreased BC cell viability and inhibited BC cell migration and invasion in vitro and suppressed tumour growth in vivo. Downregulation of hsa_circ_0043278 led to the opposite results. 34800978 circRGPD6 CircRNA Homo sapiens Breast Neoplasms metastatic breast cancer stem cells Interaction(miR-26b/YAF2 Axis) IHC//Microarray Targeted expression of circRGPD6 via human telomerase reverse transcriptase (hTERT) promoter-driven VP16-GAL4-woodchuck hepatitis virus post-transcriptional regulatory element (WPRE)-integrated systemic amplifier delivery composite vector (TV-circRGPD6) significantly inhibited expression of stem-cell marker CD44 and increased expression of the DNA damage marker p-H2AX. Yes Targeted expression of circRGPD6 via human telomerase reverse transcriptase (hTERT) promoter-driven VP16-GAL4-woodchuck hepatitis virus post-transcriptional regulatory element (WPRE)-integrated systemic amplifier delivery composite vector (TV-circRGPD6) significantly inhibited expression of stem-cell marker CD44 and increased expression of the DNA damage marker p-H2AX. 32950105 circHIPK3 CircRNA Homo sapiens Breast Neoplasms Bca cells Interaction(miR-326) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Transwell Assay The circular structure of circHIPK3 was abundantly expressed in the cytoplasm and was up-regulated in BCa. MiR-326 interacted with circHIPK3 and the two were negatively correlated. Yes Silenced circHIPK3 suppressed malignant phenotype of BCa cells. Overexpressed circHIPK3 promoted cell viability, proliferation, migration and invasion, but inhibited apoptosis. Moreover, overexpressed circHIPK3 promoted the expressions of EMT-related genes and antiapoptotic genes, but inhibited proapoptotic gene expressions.Overexpressed circHIPK3 promoted tumor growth and Ki-67 levels, inhibited apoptosis in vivo. 34135597 hsa_circ_0000442 CircRNA Homo sapiens Breast Neoplasms breast cancer tumor tissues Interaction(miR-148b-3p/PTEN/PI3K/Akt axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay In this study, the results showed a lower expression of circ_0000442 in breast cancer tumor tissues compared with the adjacent normal tissues. Subsequently, circ_0000442 was found to acted as the sponge of miR-148b-3p in breast cancer cells, thus exerting the tumor-suppressive effects. In the subsequent mechanism study, results showed that miR-148b-3p directly targeted PTEN, a well-known tumor suppressor which negatively regulats PI3K/Akt pathway, thus promoting tumor growth in breast cancer. Overall, this study for the first time identified the tumor-suppressive role of circ_0000442 in breast cancer and found PTEN as a novel direct target of miR-148b-3p. The regulatory role of circ_0000442/miR-148b-3p/PTEN/PI3K/Akt axis was preliminarily confirmed in breast cancer cells and mouse models. Yes Overall, this study for the first time identified the tumor-suppressive role of circ_0000442 in breast cancer and found PTEN as a novel direct target of miR-148b-3p. The regulatory role of circ_0000442/miR-148b-3p/PTEN/PI3K/Akt axis was preliminarily confirmed in breast cancer cells and mouse models. 32891771 circTFF1 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-338-3p/FGFR1 Axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Circ-TFF1 was overexpressed in BC tissues and cells. Circ-TFF1 acted as a sponge of miR-338-3p, and the effects of circ-TFF1 knockdown on BC cell proliferation, apoptosis, invasion, and glycolysis were abolished by miR-338-3p inhibition. FGFR1 was confirmed to be a target gene of miR-338-3p, and miR-338-3p played a tumor-suppressive role in BC by targeting FGFR1. Yes Circ-TFF1 knockdown inhibited cell proliferation, invasion and glycolysis and induced apoptosis in BC cells. 34219206 circRPPH1 CircRNA Homo sapiens Breast Neoplasms cancerous tissue Interaction(miR-512-5p-STAT1 axis) Western Blot//Wound Healing Assay//FISH//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircRPPH1 expression was higher in the cancerous tissue compared to paired adjacent tissue. In addition, circRPPH1 was mainly localized in cytoplasm and played the role of miR-512-5p sponge. By sequestering miR-512-5p from the 3'-UTR of STAT1, circRPPH1 inhibited the suppressive role of miR-512-5p, stabilized STAT1 mRNA in BC and finally affected BC progression. Yes Further in vitro and in vivo experiments indicated that circRPPH1 acted as an oncogene in BC. 34873163 hsa_circ_0000511 CircRNA Homo sapiens Breast Neoplasms BC tissue samples and cell line Interaction(miR‑326/TAZ axis) Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0000511 abundance was abnormally elevated in BC tissue samples and cell lines compared with in matched normal cases.miR‑326 was a direct target of circ_0000511, and circ_0000511 silencing‑mediated effects in BC cells were largely reversed by the knockdown of miR‑326. miR‑326 directly bound to TAZ mRNA, and TAZ accumulation largely attenuated miR‑326 overexpression‑induced effects in BC cells. Yes Circ_0000511 interference suppressed the proliferation, migration and invasion, and induced apoptosis of BC cells. 33649821 circNOLC1 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(miR-365a-3p /STAT3 axis) RNA Pull-Down//Western Blot//Migration Assay//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Invasion Assay The expression of circNOLC1 was induced in breast cancer tissues compared with the non-tumor tissues. Regarding to the mechanism, circNOLC1 functioned as a competing endogenous RNAs (ceRNAs) for microRNA-365a-3p (miR-365a-3p) and the inhibition of miR-365a-3p rescued circNOLC1 depletion-repressed proliferation and cancer stem cell activity of breast cancer. MiR-365a-3p targeted signal transducer and activator of transcription 3 (STAT3) in breast cancer cells and circNOLC1 enhanced STAT3 expression by sponging miR-365a-3p. Yes The silencing of circNOLC1 was able to repress the viability of breast cancer cells. Meanwhile, the numbers of colony formation were suppressed by circNOLC1 knockdown in breast cancer cells. The inhibition of circNOLC1 reduced the invasion and migration ability of breast cancer cells. The mRNA and protein levels of E-cadherin were enhanced but Vimentin levels were reduced by the silencing of circNOLC1. The repression of circNOLC1 decreased the side population (SP) ratio in breast cancer cells. Meanwhile, the sphere formation ability of breast cancer cells was attenuated by the silencing of circNOLC1. The levels of ATP-binding cassette (ABC) superfamily G member 2 (ABCG2), c-Myc, B cell-specific Moloney murine leukemia virus integration site 1 (Bmi1), and SRY-box transcription factor 2 (Sox2) were repressed by the depletion of circNOLC1 in the cells. 34789263 hsa_circ_0069094 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(miR-661/HMGA1 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//Transwell Assay Hsa_circ_0069094 and HMGA1 expression were significantly upregulated, while miR-661 expression level was downregulated in breast cancer tissues and cells relative to adjacent normal breast tissues or MCF-10A cells. Mechanistically, hsa_circ_0069094 regulated HMGA1 by sponging miR-661. Yes Functionally, hsa_circ_0069094 knockdown inhibited cell glycolysis, proliferation, migration and invasion, whereas induced cell apoptosis in breast cancer, which was decreased by miR-661 inhibitor. 33929992 circRPPH1 CircRNA Homo sapiens Breast Neoplasms BC patients and cells Interaction(miR-296-5p/FOXP4 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay According to the results, up-regulation of circRPPH1 was closely correlated with the poor prognosis of BC patients. In addition, circRPPH1 could sponge miR-296-5p to enhance FOXP4 expression in BC cells. miR-296-5p inhibition or FOXP4 overexpression restored the malignant properties of circRPPH1-silenced BC cells. Thus, circRPPH1 promoted BC malignant progression through regulating miR-296-5p/FOXP4 axis, indicating a possible novel therapeutic strategy involving circRNA for BC patients. According to the results, up-regulation of circRPPH1 was closely correlated with the poor prognosis of BC patients. Yes Functional experiments showed that knockdown of circRPPH1 repressed BC cell growth, migration, invasion, glycolysis, and in vivo tumor growth. 34377235 circCARM1 CircRNA Homo sapiens Breast Neoplasms BCSC exosomes Interaction(miR-1252-5p/PFKFB2) In Vivo Experiment//Western Blot//CCK8//FISH//RIP//Luciferase Report Assay//Cell Cycle Assay circCARM1 was higher in BCSC exosomes than it in the parent breast cancer cells. Further investigation demonstrated that BCSC exosomes circCARM1 played an important role in breast cancer cell glycolysis by miR-1252-5p/PFKFB2. Yes Further investigation demonstrated that BCSC exosomes circCARM1 played an important role in breast cancer cell glycolysis by miR-1252-5p/PFKFB2. 35027669 hsa_circ_0048764 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-1296-5p/TRIM14 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay It was revealed that circ_0048764 expression was remarkably up-regulated in BC tissues and cells, and circ_0048764 expression was associated with TNM stage and tumor size. Mechanistically, circ_0048764 directly targeted miR-1296-5p and could negatively modulate its expression in BC cells. Besides, miR-1296-5p could reverse the influence of circ_0048764 on BC viability, migration, invasion and apoptosis. Moreover, TRIM14 was confirmed to be a downstream target of miR-1296-5p. Circ_0048764 positively regulated TRIM14 expression in BC cells via targeting miR-1296-5p. It was revealed that circ_0048764 expression was remarkably up-regulated in BC tissues and cells, and circ_0048764 expression was associated with TNM stage and tumor size. Yes Functionally, overexpression of circ_0048764 significantly promoted BC cell proliferative, migrative and invasive abilities and inhibited apoptosis, while circ_0048764 knockdown exerted the opposite effects. 34787066 circRNF10 CircRNA Homo sapiens Breast Neoplasms BC tissues and NK cells against BC cells Interaction(miR-934/PTEN/PI3k-Akt Axis) Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//FISH//RNA-seq//Colony Formation Assay//Invasion Assay//Transwell Assay In the current study, we discovered that hsa_circ_0028899 (also called circRNF10) was significantly reduced in BC tissues, and a higher level of circRNF10 was markedly related to a favorable prognosis. These data suggest that circRNF10 serves as a molecular sponge for miR-934 to further regulate PTEN expression and PI3k/Akt/MICA signaling in vitro and tumor growth in vivo. In the current study, we discovered that hsa_circ_0028899 (also called circRNF10) was significantly reduced in BC tissues, and a higher level of circRNF10 was markedly related to a favorable prognosis. Yes The results of CCK8, colony formation, Transwell, ELISA, and NK cell-mediated cytotoxicity assays indicated that increased circRNF10 expression could significantly repress the proliferation, invasion, and migration of BC cells and enhance the killing efficiency of NK cells against BC cells. 36497344 circPRMT5 CircRNA Homo sapiens Breast Neoplasms BC tissue, MCF-10A cells Expression(highly expressed) CCK8//qRT-PCR//migration assay//Invasion Assay//Transwell Assay CircPRMT5 expression in BC tissue was higher than that in adjacent normal breast tissue. Consistently, the expression level of circPRMT5 was also elevated in serum samples collected from BC patients when compared with healthy controls. And in multiple breast cancer cell lines, circPRMT5 was upregulated as compared to normal breast epithelial MCF-10A cells. CircPRMT5 expression level was correlated with tumor size, TNM stage, lymph node metastasis distant metastasis, but no correlation was observed with ER, PR, HER2 status. Yes Overexpression of circPRMT5 promoted the proliferation, invasion, and migration of MCF7 cells; while the knockdown of circPRMT5 inhibited cell proliferation, invasion, and migration. 36161608 hsa_circ_0000129 CircRNA Homo sapiens Breast Neoplasms BC samples and cell lines Interaction( miR-485-3p/SPIN1 ) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay Circ_0000129 was overexpressed in BC samples and cell lines. Mechanically, circ_0000129 interacted with miR-485-3p to mediate the inhibiting effect of miR-485-3p on SPIN1. Silenced miR-485-3p expression weakened the inhibiting effect of circ_0000129 knockdown on BC cell malignant behaviors. Also, forced SPIN1 expression weakened miR-485-3p upregulation mediated effects on BC cell malignant behaviors. Yes Functionally, circ_0000129 silencing reduced cell proliferation, migration, invasion, and promoted cell apoptosis, as well as induced HUVEC angiopoiesis in vitro. Furthermore, circ_0000129 knockdown decreased BC cell growth in mouse xenograft models. 36426627 circIRAK3 CircRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction(miR-603/KIF2A axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Bioinformatics Analysis//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay We observed higher levels of circ_IRAK3 in BC tissues and cell lines than their respective controls. Mechanistically, circ_IRAK3 could modulate kinesin family member 2A (KIF2A) expression through acting as a microRNA (miR)-603 sponge. miR-603 silencing impaired the effects of circ_IRAK3 inhibition on the malignant behaviors of BC cells. Also, the repressive effects of miR-603 mimic on the malignant behaviors of BC cells were weakened by KIF2A overexpression. Yes Functional experiments presented that circ_IRAK3 silencing induced BC cell apoptosis, curbed cell proliferation, migration, and invasion in vitro, and decreased tumor growth in vivo. 35164763 hsa_circ_0000514 CircRNA Homo sapiens Breast Neoplasms bc tissues and cell lines Interaction(miR-296-5p/CXCL10 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU//Transwell Assay We demonstrated that circ_0000514 and CXCL10 expressions were raised in bc tissues and cell lines while miR-296-5p expression was declined.Mechanistically, miR-296-5p was identified as the downstream target of circ_0000514 and could be inhibited by circ_0000514. Moreover, CXCL10 was the target of miR-296-5p, whose expression could be indirectly and positively regulated by circ_0000514. Yes Circ_0000514 knockdown could inhibit the proliferation, migration and invasion of bc cells and miR-296-5p overexpression also suppressed the malignant phenotypes of bc cells. 34528678 circROBO1 CircRNA Homo sapiens Breast Neoplasms BC cells Interaction( circROBO1/KLF5/FUS) In Vivo Experiment//RNA Pull-Down//Wound Healing Assay//Migration Assay//CCK8//RIP//RNA-seq//Invasion Assay//ChIP In this study, upregulated expression of circROBO1 was found in BC-derived liver metastases and was correlated with poor prognosis. Further research revealed that circROBO1 could upregulate KLF5 by sponging miR-217-5p, allowing KLF5 to activate the transcription of FUS, which would promote the back splicing of circROBO1. Therefore, a positive feedback loop comprising circROBO1/KLF5/FUS was formed. More importantly, we found that circROBO1 inhibited selective autophagy of afadin by upregulating KLF5. In this study, upregulated expression of circROBO1 was found in BC-derived liver metastases and was correlated with poor prognosis. Yes Knockdown of circROBO1 strikingly inhibited the proliferation, migration, and invasion of BC cells, whereas overexpression of circROBO1 showed the opposite effects. Moreover, overexpression of circROBO1 promoted tumor growth and liver metastasis in vivo. 35073911 hsa_circ_0001429 CircRNA Homo sapiens Breast Neoplasms human breast cancer cell lines BT474, SKBr-3, ZR-75-30, and MCF7 Interaction(miR-205/KDM4A ) CCK8 hsa_circ_000 1429 may upregulate the KDM4A gene by adsorbing miR-205. Therefore, it will promote the proliferation, migration, and invasion of breast cancer cells and inhibit their apoptosis. Yes hsa_circ_000 1429 may upregulate the KDM4A gene by adsorbing miR-205. Therefore, it will promote the proliferation, migration, and invasion of breast cancer cells and inhibit their apoptosis. 35833065 hsa_circ_0000442 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-1229-3p/ZBTB1 axis) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ_0000442 expression was downregulated and miR-1229-3p expression was upregulated in BC tissues and cells. Circ_0000442 directly interacted with miR-1229-3p. The anti-tumor role of circ_0000442 was attributed to the sponge effect on miR-1229-3p. ZBTB1 was a downstream target for miR-1229-3p. Downregulation of miR-1229-3p blocked the malignant behaviors in BC cells by elevating the expression of ZBTB1. Circ_0000442 regulated the ZBTB1 level by targeting miR-1229-3p, and it inhibited tumor growth of BC in vivo by mediating the miR-1229-3p/ZBTB1 axis. Yes Circ_0000442 repressed proliferation, migration, invasion and glycolysis but promoted apoptosis in BC cells. 35394175 hsa_circ_0069094 CircRNA Homo sapiens Breast Neoplasms tissues and cells of breast cancer Interaction(miR-758-3p/ZNF217 ) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Hsa_circ_0069094 and ZNF217 were highly expressed, while miR-758-3p was poorly expressed in tissues and cells of breast cancer. Hsa_circ_0069094 competed with ZNF217 for the binding site of miR-758-3p, and hsa_circ_0069094 positively regulated ZNF217 expression by competitively binding to miR-758-3p. Hsa_circ_0069094 knockdown also blocked solid tumor growth in mice. Collectively, Hsa_circ_0069094 played oncogenic effects in breast cancer by activating the expression of ZNF217 via competitively binding to miR-758-3p, which might be a novel strategy for breast cancer suppression. Yes Hsa_circ_0069094 knockdown or ZNF217 knockdown inhibited cell proliferation, invasion and migration and induced cell apoptosis and cell cycle arrest in breast cancer cells. The inhibitory effects of hsa_circ_0069094 knockdown on cell malignant behaviors were abolished by ZNF217 overexpression. 36356557 hsa_circ_0002082 CircRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction(miR-508-3p/CENPF axis) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay Hsa_circ_0002082 expression was higher in BC tissues and cell lines.Mechanistically, hsa_circ_0002082 targeted miR-508-3p, which was confirmed to be decreased in BC. MiR-508-3p overexpression suppressed BC cell malignant phenotypes, moreover, inhibition of miR-508-3p attenuated the anticancer action of hsa_circ_0002082 silencing on BC cells. Besides that, miR-508-3p targeted CENPF, CENPF was highly expressed in BC, CENPF up-regulation reversed the suppressive impacts of miR-508-3p on BC cell growth and metastasis. Yes Functionally, knockdown of hsa_circ_0002082 induced apoptosis and suppressed proliferation and metastasis in BC cells in vitro. Besides, hsa_circ_0002082 silencing impeded BC growth in nude mice. 36161346 hsa_circ_0039960 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-1178/PRMT7 axis) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay//PCR//Cell Cycle Assay//Bioinformatics Analysis The results showed that circ_0039960 and PRMT7 were both up-regulated, while miR-1178 was down-regulated, in BC tissues and cells. Moreover, we validated that circ_0039960 positively mediated PRMT7 expression via directly targeting to miR-1178. The inhibition of miR-1178 and overexpression of PRMT7 reversed the effect of circ_0039960 knockdown on BC cell growth and Warburg effect. Yes Silencing circ_0039960 effectively inhibited cell viability and Warburg effect of BC cells, also, induced cell cycle arrest and apoptosis. 35597500 hsa_circ_0089153 CircRNA Homo sapiens Breast Neoplasms BCa patients and cells Interaction(miR-2467-3p/E2F6) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay The up-modulated circ_0089153 indicated an unfavorable survival of BCa patients. circ_0089153 was miR-2467-3p sponge. Low miR-2467-3p expression indicated a worse survival of BCa patients. miR-2467-3p overexpression reduced BCa cells proliferation, migration, invasion and EMT (P < .05). circ_0089153 enhanced BCa cells proliferation, migration, invasion and EMT by sponging miR-2467-3p (P < .05). E2F6 was directly suppressed by miR-2467-3p. E2F6 high expression in BCa patients associated with worse survival. circ_0089153 knockdown suppressed in vivo BCa cells growth and lung metastasis (P < .01). circ_0089153 was an oncogene in breast cancer, which enhanced proliferation and metastasis through sponging miR-2467-3p/E2F6. The up-modulated circ_0089153 indicated an unfavorable survival of BCa patients. Yes circ_0089153 knockdown attenuated BCa cells proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) (P < .01). 35225430 circEZH2 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(FUS/circEZH2/KLF5/CXCR4 ) In Vivo Experiment In our research, circEZH2 was proved to be upregulated in liver metastases in BC and predicted the worse prognosis in breast cancer patients. Moreover, circEZH2 could adsorb miR-217-5p to upregulate KLF5 thus leading to activate FUS transcription which would facilitate the back-splicing program of circEZH2. Meanwhile, KLF5 could upregulated CXCR4 transcriptionally to accelerate epithelial and mesenchymal transition of breast cancer. In our research, circEZH2 was proved to be upregulated in liver metastases in BC and predicted the worse prognosis in breast cancer patients. Yes Overexpression of circEZH2 notably accentuated the vitality and invasion of BC cells, whereas knockdown of circEZH2 elicited the literally opposite effects. Besides, overexpressed circEZH2 promoted tumorigenesis and liver metastasis in vivo. 36224562 hsa_circ_0041732 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction(miR-541-3p/RelA/GLI4 ) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining According to experimental results, significant upregulation of circ_0041732 was confirmed in breast cancer tissues and cell lines. E2F4 was proved to transcriptionally modulate circ_0041732.circ_0041732 could sponge miR-541-3p to enhance expression levels of RelA and GLI4, thus activating NFκB and Hedgehog pathways and affecting breast cancer cell proliferation, cell cycle, and apoptosis. In all, E2F4-mediated circ_0041732 could activate RelA/NFκB and GLI4/Hedgehog signaling pathways via modulation on miR-541-3p/RelA/GLI4 to promote breast cancer progression. Yes Moreover, circ_0041732 was validated to accelerate breast cancer cell proliferation and impede G2-M arrest and cell apoptosis, and the oncogenic role of circ_0041732 in breast cancer was further verified via in vivo experiments. 35838496 hsa_circ_0006014 CircRNA Homo sapiens Breast Neoplasms breast tumor samples and cells Interaction(miR-885-3p/NTRK2/PIK3CA/AKT axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//Transwell Assay In this study, we found higher expression of hsa_circ_0006014 in breast tumor samples than in matched adjacent normal samples, and its expression was positively correlated with histological grade (grade iii). Mechanistically, there were confirmed binding sites between hsa_circ_0006014 and miR-885-3p, and hsa_circ_0006014 promoted breast cancer cell proliferation partially by sponging miR-885-3p and influenced CDK2/CCNE1 and CDK4/6/CCND1. Furthermore, we found that hsa_circ_0006014 regulated NTRK2 through miR-885-3p to modulate the PIK3/AKT signaling pathway. Our results demonstrated that hsa_circ_0006014 promotes breast cancer progression by sponging miR-885-3p to regulate the NTRK2/PIK3CA/AKT axis. In this study, we found higher expression of hsa_circ_0006014 in breast tumor samples than in matched adjacent normal samples, and its expression was positively correlated with histological grade (grade iii). Yes Phenotypically, hsa_circ_0006014 promoted the proliferation of MDA-MB-231 and MCF-7 breast cancer cells. 35383130 hsa_circ_0067934 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and NSCLC cells Expression[highly expressed] qRT-PCR The results of the present study demonstrated that the expression levels of circ-0067934 were significantly increased in non-small cell lung cancer (NSCLC) tissues and NSCLC cells compared with that in adjacent normal tissues and a normal human bronchial epithelium cell line, as assessed using reverse transcription-quantitative polymerase chain reaction. Increased expression levels of circ-0067934 were associated with lymph node metastasis and advanced tumor stage in patients with NSCLC. Increased levels of circ-0067934 were significantly associated with the poor overall survival (OS) time of patients with NSCLC compared with low circ-0067934 expression levels, as assessed using Kaplan-Meier estimator survival curves and log-rank tests. Yes The results demonstrated that the proliferative ability was significantly inhibited when circ-0067934 was knocked down in NSCLC cells. 30344708 hsa_circ_0003998 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[hsa_circ_0003998/miR-326/Notch1 pathway ] qRT-PCR//Luciferase Report Assay hsa_circ_0003998/miR-326/Notch1 pathway regulates the progression of NSCLC. Hsa_circ_0003998 upregulation was associated with larger tumor size and lymph node metastasis and also correlated with shorter overall survival of NSCLC patients. Yes Functional experiments showed knockdown of hsa_circ_0003998 restrained cell proliferation and invasion in NSCLC cells. 30237723 hsa_circ_0033155 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue Expression[lower expressed] qRT-PCR In the present study, it was demonstrated that the expression level of hsa_circ_0033155 was significantly downregulated in NSCLC tissue and the expression of hsa_circ_0033155 correlated with lymphatic metastasis. In the present study, it was demonstrated that the expression level of hsa_circ_0033155 was significantly downregulated in NSCLC tissue and the expression of hsa_circ_0033155 correlated with lymphatic metastasis. Yes In order to further investigate the possible role of hsa_circ_0033155 in NSCLC progression, circRNA was overexpressed in NSCLC cells and it was observed that the overexpression of hsa_circ_0033155 significantly decreased cell proliferation, colony formation and migration, and elevated the level of phosphatase and tensin homolog deleted on chromosome 10, a tumor suppressor in many types of tumor. 30214545 hsa_circ_0020123 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cancer tissues Regulation[hsa_circ_0020123-miR-144-ZEB1/EZH2 axis] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Herein, a novel functional circRNA hsa_circ_0020123 had been identified in NSCLC progression in this study, and elevated hsa_circ_0020123 expression could be observed in cancer tissues compared with that in matched normal lung tissues. Moreover, up-regulation of hsa_circ_0020123 was recognized to be closely associated with a poor differentiation degree, lymph node metastasis, a high TNM stage and dismal prognosis for NSCLC patients. Yes Typically, knockdown of hsa_circ_0020123 could inhibit the NSCLC growth and metastasis both in vitro and in vivo, which could be reversed by the hsa_circ_0020123 overexpression. 30210911 hsa_circ_0007534 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue samples and cell lines Expression[highly expressed] qRT-PCR The results indicated that hsa_circ_0007534 was up-regulated in both NSCLC tissue samples and cell lines and this up-regulation is linked to lymph node invasion and advanced TNM stage. The results indicated that hsa_circ_0007534 was up-regulated in both NSCLC tissue samples and cell lines and this up-regulation is linked to lymph node invasion and advanced TNM stage. Hsa_circ_0007534 could also function as an unfavorable prognostic indicator for the patients with NSCLC. Yes For the part of functional assays, down-regulation of hsa_circ_0007534 suppressed cell growth, migratory and invasive capacities; facilitating cell apoptosis in A549 and H1299 cells. 30017736 circTFF1 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction( miR-129-2-3p/IRAK1 Axis) In Vivo Experiment//IHC//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ-TFF1 and IRAK1 were significantly high expressed in BC tissues and cells.MiR-129-2-3p was a target of circ-TFF1. Silencing of circ-TFF1 inhibited the malignant behavior of BC cells by releasing miR-129-2-3p. In addition, IRAK1 was a target of miR-129-2-3p. Overexpression of IRAK1 partially restored the inhibitory effect of miR-129-2-3p on cell progression. Yes Silencing of circ-TFF1 reduced the proliferation, migration, invasion and tube formation, while increased the apoptosis of MDA-MB-361 and SK-Br-3 cells. Animal experiments confirmed the anti-tumor effect of circ-TFF1 knockdown in vivo. 35279761 circBRWD3 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-142-3p_miR-142-5p/RAC1/PAK1 signaling) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay qRT-PCR analysis revealed that circBRWD3 expression was dramatically upregulated in BC tissues, a feature that was positively correlated with the poor prognosis of patients with BC. Further, mechanistic studies elucidated that circBRWD3 sponged both miR-142-3p and miR-142-5p to modulate RAC1 expression, which subsequently activated the RAC1/PAK1 signaling to facilitate the tumorigenesis and progression of BC. Yes CircBRWD3 knockdown repressed cell proliferation and metastasis, while promoting cell apoptosis in vitro. Consistently, an in vivo circBRWD3 deficiency model exhibited suppressed tumor metastasis and oncogenesis. On the other hand, circBRWD3 overexpression promoted cancer cell activity and tumorigenesis. 36443711 hsa_circ_0001583 CircRNA Homo sapiens Breast Neoplasms MCF-7 cells Regulation qRT-PCR//MTT//Colony Formation Assay Functional experiments showed that depletion of circ_0008812 and circ_0001583 could significantly inhibit the proliferation of MCF-7 cells. Yes Functional experiments showed that depletion of circ_0008812 and circ_0001583 could significantly inhibit the proliferation of MCF-7 cells. 36200070 hsa_circ_0102273 CircRNA Homo sapiens Breast Neoplasms BC tumor tissues and cells Interaction(miR-1236-3p/PFKFB3 axis) In Vivo Experiment//Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay Our data showed that circ_0102273 was highly expressed in BC tumor tissues and cells, and its downregulation could inhibit BC cell proliferation, metastasis and glycolysis. PFKFB3 could be targeted by miR-1236-3p, and its expression could be positively regulated by circ_0102273. In addition, miR-1236-3p could suppress BC cell proliferation, metastasis and glycolysis, while this effect could be abolished by PFKFB3. Furthermore, circ_0102273 knockdown also had been discovered to reduce BC tumorigenesis in vivo. Yes MiR-1236-3p was confirmed to be sponged by circ_0102273, and its inhibitor could reverse the negative regulation of sh-circ_0102273 on BC cell proliferation, metastasis and glycolysis. 35266884 hsa_circ_0001955 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(miR-1299/GLUT1 pathway) Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Upregulation of circ_0001955 was detected in breast cancer.MiR-1299 was a target of circ_0001955, and its repression reversed the effects of circ_0001955 knockdown. Moreover, circ_0001955 targeted miR-1299 to positively regulate GLUT1 expression. GLUT1 overexpression reversed the effects of miR-1299 enrichment. GLUT1 knockdown was verified to block tumor growth in vivo. Yes Knockdown of circ_0001955 inhibited breast cancer cell proliferation, migration, invasion, angiogenesis and glycolysis. 35174654 hsa_circ_002172 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-296-5p/CXCL12 axis) IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Upregulation of circ_002172 and CXCL12 and downregulation of miR-296-5p occurred in BC tissues and cells.. Circ_002172, as a miR-296-5p sponge, upregulated expression CXCL12. Moreover, Ectopic expression of circ_002172 inhibited cytotoxic T lymphocytes (CTL) infiltration to promote the immune escape of BC. Yes Circ_002172 promoted the oncogenic phenotypes of BC cells in vitro and growth of tumors in vivo, which was reversed by knockdown of CXCL12 expression. 35240495 circADAM9 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(miR-383-5p/PFN2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay We found that circ-ADAM9 was upregulated in breast cancer tissues and cells compared to controls. The functional effects of circ-ADAM9 were related to miR-383-5p, a target of circ-ADAM9. Overexpression of miR-383-5p-mediated malignant behaviors and radiosensitivity of breast cancer cells were dependent on PFN2. Yes Inhibition of circ-ADAM9 expression impaired proliferation, migration, and invasion, but increased radiosensitivity and apoptosis in breast cancer cells; 36205752 hsa_circ_0008784 CircRNA Homo sapiens Breast Neoplasms TNBC cells Interaction(miR-506-3p/CTNNB1) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay It was found that circ_0008784 regulates Wnt/β-catenin signaling pathway, and augments TNBC cell progression via sponging miR-506-3p to modulate catenin beta 1 (CTNNB1). Yes Circ_0008784 activates Wnt/β-catenin pathway to affect the proliferation and apoptosis of TNBC cells. 36436315 hsa_circ_0047604 CircRNA Homo sapiens Breast Neoplasms breast cancer tissue Interaction(miR-548o-DACH1 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay In this work, hsa_circ_0047604 expressed lower in breast cancer tissue and played the role of sponge of miR-548o.By this way, hsa_circ_0047604 could upregulate DACH1 to inhibit breast cancer. Yes In conclusion, this study revealed that hsa_circ_0047604 acted as a tumor suppressor and regulated breast cancer progression via hsa_circ_0047604-miR-548o-DACH1 axis, which might provide a therapeutic method for breast cancer. 35097124 circSEMA4B CircRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction(miR-330-3p/PDCD4 axis) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//Co-IP//qRT-PCR//RIP//MTT//Luciferase Report Assay//ELISA//Colony Formation Assay//Transwell Assay Both circSEMA4B and SEMA4B-211aa were remarkably downregulated in BC tissues and cell lines. Of note, SEMA4B-211aa inhibited the generation of PIP3 by binding to p85, thereby inhibiting the phosphorylation of AKT (Thr308). CircSEMA4B inhibited the phosphorylation of AKT (Ser473) through miR-330-3p/PDCD4 axis. Low expression of circSEMA4B was positively associated with TNM stage, tumor size, lymph node metastasis, and distant metastasis of BC patients. Yes The functional investigation showed that circSEMA4B and SEMA4B-211aa could significantly inhibit the proliferation and migration of BC in vivo and in vitro. 36115854 circHIPK3 CircRNA Homo sapiens Breast Neoplasms BC cell Interaction(miR-124-3p/MTDH axis) IHC//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay HIPK3s were mainly in forms of circRNAs and were highly expressed in the BC cell derived exosomes, which could be absorbed by the recipient ECs. Furthermore, MTDH was proved to be the responsible gene in this process which was regulated by miR-124-3p, the local miRNA sponged by the exosomal circHIPK3.circHIPK3 enclosed in the BC cell-derived exosomes enhanced MTDH expression in the endothelial cell by sponging miR-124-3p, favoring the tube formation in ECs, which might serve as a therapeutic target for anti-angiogenesis therapy for breast cancer. Yes The cell viability and angiogenesis in ECs were enhanced when treated with circHIPK3s and decreased when treated with circHIPK3-si. 35460835 circATXN7 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(miR-149-5p/HOXA11 pathway) RNA Pull-Down//IHC//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircATXN7 and HOXA11 levels were enhanced, whereas miR-149-5p level was declined in breast cancer tissues and cells. Additionally, circATXN7 upregulated HOXA11 via absorbing miR-149-5p, thereby inducing breast cancer cell progression and reducing doxorubicin sensitivity. Yes CircATXN7 silencing suppressed breast cancer development and doxorubicin resistance. 34845164 circEPSTI1 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(circEPSTI1/miR-145/ERBB3 Axis) Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay//Transwell Assay CircEPSTI1 was upregulated in the HER2-positive breast cancer tissues and cells.Mechanistically, circEPSTI1 directly targeted miR-145, and miR-145 was a downstream mediator of circEPSTI1 in modulating the proliferation, migration, and invasion of SKBR3 and BT474 cells. ERBB3 was identified as a direct and functional target of miR-145 in HER2-positive breast cancer cells. Yes Knockdown of circEPSTI1 inhibited SKBR3 and BT474 cell proliferation, migration, and invasion. 36059813 hsa_circ_0008812 CircRNA Homo sapiens Breast Neoplasms MCF-7 cells Regulation qRT-PCR//MTT//Colony Formation Assay Functional experiments showed that depletion of circ_0008812 and circ_0001583 could significantly inhibit the proliferation of MCF-7 cells. Yes Functional experiments showed that depletion of circ_0008812 and circ_0001583 could significantly inhibit the proliferation of MCF-7 cells. 36200070 circRAD54L2 CircRNA Homo sapiens Breast Neoplasms breast cancer cells. Interaction(miR-888 family/PDK1 axis) Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Invasion Assay This study identified and characterized the circRAD54L2 originating from exon 1, 2, 3, and 4 of the RAD54L2 gene. Importantly, we found that circRAD54L2, rather than RAD54L2 linear mRNA, was significantly upregulated in breast cancer cell lines. Furthermore, we found that inhibiting circRAD54L2 expression markedly reduced the invasion, metastasis, and proliferation of breast cancer cells via sponging of the miR-888 family, which downregulated the expression of pyruvate dehydrogenase kinase 1 (PDK1).Our results showed that circRAD54L2 could regulate PDK1 expression by sponging the miR-888 family competing for the ceRNA mechanism, indicating that circRAD54L2 may act as an essential upstream regulator and providing further mechanistic evidence to support the notion that circRAD54L2/miR-888s/PDK1 is a promising therapeutic target in the treatment of breast cancer. Yes Furthermore, we found that inhibiting circRAD54L2 expression markedly reduced the invasion, metastasis, and proliferation of breast cancer cells via sponging of the miR-888 family, which downregulated the expression of pyruvate dehydrogenase kinase 1 (PDK1). 36334805 circWAC CircRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Regulation(miR-599/E2F3 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay CircWAC was up-regulated in BC tissues and cell lines. CircWAC knockdown restrained the proliferation, migration, invasion, and glycolysis and promoted the apoptosis of BC cells. CircWAC acted as miR-599 sponge, and miR-599 interference largely reversed circWAC silencing-induced effects in BC cells. MiR-599 interacted with the 3' untranslated region (3'UTR) of E2F3, and miR-599 overexpression-induced suppressive effect on cellular malignant potential was overturned by the accumulation of E2F3 in BC cells. Eukaryotic initiation factor 4A3 (eIF4A3) induced the expression of circWAC in BC cells. CircWAC knockdown suppressed xenograft tumor growth in vivo. Yes CircWAC knockdown suppressed xenograft tumor growth in vivo. 34989110 circLARP4 CircRNA Homo sapiens Breast Neoplasms cells Expression(highly expressed) Western Blot//CCK8//qRT-PCR//ELISA//Transwell Assay Results Compared with the control group, circ_LARP4 overexpression group showed an upregulation in the expression of circ_LARP4, decreased cell proliferation, and down-regulated expression of ki67. It also reported the up-regulated expression of p21, smaller tumor stem cell bullet size, and decreased the expression of OCT4 and SOX2, together with the decreased number of invaded cells, decreased expression of VEGF and N-cadherin, increased expression of E-cadherin, and decreased levels of iNOS and IL-1β. Yes Results Compared with the control group, circ_LARP4 overexpression group showed an upregulation in the expression of circ_LARP4, decreased cell proliferation, and down-regulated expression of ki67. It also reported the up-regulated expression of p21, smaller tumor stem cell bullet size, and decreased the expression of OCT4 and SOX2, together with the decreased number of invaded cells, decreased expression of VEGF and N-cadherin, increased expression of E-cadherin, and decreased levels of iNOS and IL-1β. 35365990 circKDM4B CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(miR-675/NEDD4L axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//IP//ELISA//Transwell Assay It was significantly decreased in breast cancer tissues compared with adjacent non-tumor tissues. In addition, the overexpression of circKDM4B inhibited cell migration and invasion in vitro, while knockdown of circKDM4B induced the opposite effects. In vivo, circKDM4B suppressed tumor growth and metastasis. Mechanically, circKDM4B sponged miR-675 to upregulate the expression of NEDD4-like E3 ubiquitin protein ligase (NEDD4L), which catalyzes ubiquitination of PI3KCA, thereby inhibiting PI3K/AKT and VEGFA secretion. Yes In addition, the overexpression of circKDM4B inhibited cell migration and invasion in vitro, while knockdown of circKDM4B induced the opposite effects. In vivo, circKDM4B suppressed tumor growth and metastasis. Additionally, circKDM4B inhibited migration and tube formation of human umbilical vein endothelial cells (HUVECs) in vitro and angiogenesis in vivo. 35145234 circCCDC85A CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(miR-550a-5p/MOB1A) Western Blot//Bioinformatics Analysis//Wound Healing Assay//Migration Assay//CCK8//FISH//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The expression of circCCDC85A in breast cancer tissues was obviously lower than that in normal breast tissues. Moreover, enforced expression of circCCDC85A inhibits the oncogenic activity of miR-550a-5p and increases the expression of MOB1A targeted by miR-550a-5p. Further molecular mechanism research showed that circCCDC85A may act as a molecular sponge for miR-550a-5p, thus restoring miR-550a-5p-mediated targeting repression of tumor suppressor MOB1A in breast cancer cells. Yes Over-expression of circCCDC85A substantially inhibited the proliferative, migrative, and invasive ability of breast cancer cells, while knocking down of circCCDC85A enhanced the aforementioned properties of breast cancer cells. 34983617 hsa_circ_0012673 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction(miR-576-3p/SOX4 Axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Herein, we found that the expression of hsa_circ_0012673 was upregulated in breast cancer tissues and cell lines.Mechanistically, hsa_circ_0012673 sponged miR-576-3p to stabilize SRY-box transcription factor 4 (SOX4), and thereby facilitating breast cancer cell proliferation, migration and invasion. Collectively, our study identified the oncogenic properties of hsa_circ_0012673/miR-576-3p/SOX4 axis in breast cancer, providing potential and exploitable diagnostic and therapeutic molecules for breast cancer. Yes Knockdown of hsa_circ_0012673 using RNA interference technique suppressed the proliferation, migration, and invasion of breast cancer cells. 35794450 circZFR CircRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction(miR-223-3p/FABP7) In Vivo Experiment//Western Blot//CCK8//Luciferase Report Assay//Transwell Assay The expression levels of circ_ZFR and FABP7 were higher in BC tissues and cell lines, whereas miR-223-3p expression was lower. Furthermore, circ_ZFR might act as a sponge for miR-223-3p to regulate FABP7 expression, thereby promoting the progression of BC cells in vitro and in vivo. Yes Knockdown of circ_ZFR or FABP7 in BC cells reduced proliferation, migration, invasion, and epithelial mesenchymal transition (EMT), and induced apoptosis in vitro, whereas the opposite effects were observed in circ_ZFR-overexpressed cells. 35355424 hsa_circ_0000518 CircRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction(miR-1225-3p/SOX4 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay It was revealed that, circ_0000518 and SOX4 mRNA expression levels were up-modulated in BC tissues, while miR-1225-3p expression was down-modulated in BC tissues than that in adjacent tissues. Circ_0000518 was identified as a molecular sponge of miR-1225-3p, and it can up-regulate SOX4 mRNA expression via repressing miR-1225-3p. In conclusion, circ_0000518 is oncogenic in BC and functions through miR-1225-3p/SOX4 axis. Yes Circ_0000518 overexpression or inhibition of miR-1225-3p remarkably enhanced the growth, migration as well as invasion of BC cells in vitro, whereas circ_0000518 knockdown or miR-1225-3p overexpression worked oppositely. 35112991 circN4BP2L2 CircRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC patients Expression(lower expressed) qRT-PCR//ELISA Plasma circN4BP2L2 was significantly downregulated in EOC patients. Decreased circN4BP2L2 was significantly associated with advanced tumor stage, worse histological grade, lymph node metastasis and distant metastasis in EOC. Yes CircN4BP2L2 inhibited tumor cell migration and invasion in vitro. 34980005 circATP2B4 CircRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues Interaction(miR-532-3p/SREBF1/PI3Kα/AKT axis) qRT-PCR//RNA-seq//FISH CircATP2B4 was upregulated in EOC tissues and positively correlated with ovarian cancer progression.Mechanistically, EV-packaged circATP2B4 in EOC could be transmitted to infiltrated macrophages and acted as competing endogenous RNA of miR-532-3p to relieve the repressive effect of miR-532-3p on its target SREBF1. Furthermore, circATP2B4 induced macrophage M2 polarization by regulating the miR-532-3p/SREBF1/PI3Kα/AKT axis, thereby leading to immunosuppression and ovarian cancer metastasis. Yes Functionally, circATP2B4 promoted carcinogenic progression and metastasis of EOC both in vitro and in vivo. 36512324 circRHOBTB3 CircRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues and cells Interaction(miR-23a-3p/PTEN) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//FISH Furthermore, it revealed that circRHOBTB3 could serve as the ceRNA of miR-23a-3p to facilitate PTEN expression, suppress proliferation, G1/S transition, invasion, and promote apoptosis in EOC. Yes Furthermore, it revealed that circRHOBTB3 could serve as the ceRNA of miR-23a-3p to facilitate PTEN expression, suppress proliferation, G1/S transition, invasion, and promote apoptosis in EOC. 35650643 hsa_circ_100290 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck oral squamous cell carcinoma tissues Interaction[ miR-378a,GLUT1] qRT-PCR//Luciferase Report Assay//IHC Reportedly, hsa_circular RNA (circRNA)_100290 (circ_SLC30A7) is significantly Expression[Expression[up-expression]-expression]regulated (fold change = 6.91, p < 0.0000001) in OSCC. The effect of miR-378a overexpression on OSCC cells was similar to those of circRNA_100290 silence. miR-378a directly bound to circRNA_100290 and GLUT1 3'-untranslated region, circRNA_100290 could remarkably relieve miR-378a-induced inhibition on GLUT1 via acting as a competing endogenous RNA (ceRNA). miR-378a inhibition remarkably attenuated the effect of circRNA_100290 silence on cell proliferation and glycolysis in OSCC cell lines. Yes Herein, the expression of circRNA_100290 and GLUT1 remarkably increased in oral tumor tissue specimens and cells.In OSCC cell lines, cell proliferation and glycolysis could be remarkably Expression[down-expression]regulated by circRNA_100290 silence, which could be rescued by GLUT1 overexpression. 31187488 hsa_circ_0007059 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissue Interaction[AKT/mTOR] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//EdU Staining The circRNA hsa_circ_0007059 was downregulated in OSCC. Subsequently, hsa_circ_0007059 levels in OSCC tissues and cell lines were assessed by quantitative reverse-transcription chain reaction.Furthermore, nude mouse tumor formation was assessed to validate the tumor-sExpression[up-expression]pressive role of hsa_circ_0007059 in vivo. Finally, hsa_circ_0007059 was determined to alter cell growth via AKT/mTOR signaling, representing a potential prognostic/therapeutic target for OSCC. Yes Importantly, hsa_circ_0007059 Expression[up-expression]regulation sExpression[up-expression]pressed cell growth, migration, and invasion, facilitating apoptosis of these cells. 30680715 hsa_circ_102459 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] CCK8//Flow Cytometry//EdU Staining//qRT-PCR The results revealed that hsa_circRNA_102459 was significantly downregulated and hsa_circRNA_043621 was significantly upregulated in OSCC tissues. Clinical stage, tumor differentiation, lymph node metastasis presented significant difference in regards to the expression of circRNA_043621 and circRNA_102459. Yes The in vitro experiments further demonstrated that upregulation of circRNA_102459 or downregulation of circRNA_043621 significantly suppressed TSCC1 cell proliferation, induced cell cycle G0/G1 phase arrest and promoted apoptosis. 31638251 hsa_circ_043621 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] CCK8//Flow Cytometry//EdU Staining//qRT-PCR The results revealed that hsa_circRNA_102459 was significantly downregulated and hsa_circRNA_043621 was significantly upregulated in OSCC tissues. Clinical stage, tumor differentiation, lymph node metastasis presented significant difference in regards to the expression of circRNA_043621 and circRNA_102459. Yes The in vitro experiments further demonstrated that upregulation of circRNA_102459 or downregulation of circRNA_043621 significantly suppressed TSCC1 cell proliferation, induced cell cycle G0/G1 phase arrest and promoted apoptosis. 31638251 circPKD2 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Regulation[miR-204-3p/APC2 axis] qRT-PCR We found that downregulation of circ-PKD2 in OSCC correlated significantly with aggressive characteristics.In addition, circ-PKD2 was identified as a sponge for miR-204-3p and upregulated the expression of adenomatous polyposis coli 2 (APC2), which was the functional target of miR-204-3p. Moreover, circ-PKD2 attenuated the oncogenic effects of miR-204-3p-mediated APC2 on OSCC progression via multiple signaling pathways. Yes Further analysis revealed that overexpression of circ-PKD2 inhibited OSCC cell proliferation, migration and invasion, induced apoptosis and cell cycle arrest, which were promoted by knockdown of circ-PKD2. 31206208 circPVT1 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues,cell lines Regulation[circPVT1/miR‑125b axis] CCK8//qRT-PCR It was identified that circPVT1 was upregulated in OSCC cells and specimens.Mechanistically, it was demonstrated that circPVT1 possessed two targeting sites of microRNA (miRNA/miR)‑125b and could effectively sponge miR‑125b to release its downstream mRNA targets. Subsequently, the downstream target signal transducer and activator of transcription 3 (STAT3) was verified as a direct target of miR‑125b and STAT3 expression was regulated by the circPVT1/miR‑125b axis. CircPVT1 functioned as competing endogenous RNA (ceRNA) to increase the STAT3 level and cell proliferation through sponging miR‑125b. In conclusion, circPVT1 regulates cell proliferation and may serve as a promising therapeutic target for OSCC patients. Therefore, silencing of circPVT1 could be a future direction to develop a novel treatment strategy. Yes Knockdown of circPVT1 suppressed cell proliferation as evidenced by Cell Counting kit‑8 assay and elevated Ki‑67 expression. 31485648 hsa_circ_0005379 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Interaction[EGFR pathway] Flow Cytometry//qRT-PCR//Western Blot//Transwell Assay We found that circRNA hsa_circ_0005379 expression is significantly lower in OSCC tissue compared to paired non-cancerous matched tissue and is associated with tumor size and differentiation. Mechanistic studies revealed that hsa_circ_0005379 may be involved in the regulation of the epidermal growth factor receptor (EGFR) pathway. Furthermore, we found that high expression of hsa_circ_0005379 could significantly enhance the sensitivity of OSCC to the cetuximab drug. We found that circRNA hsa_circ_0005379 expression is significantly lower in OSCC tissue compared to paired non-cancerous matched tissue and is associated with tumor size and differentiation. Yes Overexpression of hsa_circ_0005379 effectively inhibits migration, invasion, and proliferation of OSCC cells in vitro and suppresses OSCC growth in nude mice in vivo. 31035951 hsa_circ_0063772 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay The expression of circular RNA hsa_circ_0063772 in OSCC tissues (9.38±0.34) was lower than that in adjacent tissues (11.30±0.31) (t=5.20, P<0.001), and the expression in OSCC cells (SCC15: 0.12±0.01; SCC25: 0.18±0.02; SCC9: 0.21±0.01; CAL27: 0.13±0.01) was significantly lower than that in human keratinocytes (1.02±0.02) (t(SCC15)=41.91, t(SCC25)=29.21, t(SCC9)=35.16, t(CAL27)=41.86, P<0.001). Yes Overexpression of hsa_circ_0063772 in SCC15 and CAL27 cells can affect tumor cell proliferation, cell counting assay showed that tumor cell proliferation ability in high expression group (SCC15: 0.76±0.01; CAL27: 0.74±0.02) were lower than empty group (SCC15∶1.22±0.04; CAL27: 0.99±0.03; t(SCC15)=12.58, t(CAL27)=6.97; P<0.05). 31378036 circIGHG CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues interaction[miR-142-5p/IGF2BP3 Signaling] RNA Pull-Down//Northern Blot//Western Blot//CCK8//FISH//RIP//Luciferase Report Assay//IHC Transcriptomic analyses identified a circRNA derived from IGHG locus (circIGHG) as significantly upregulated in OSCC and positively associated with poor prognosis of OSCC.Epithelial-mesenchymal transition was the main mechanism through which circIGHG/IGF2BP3 promotes metastasis of OSCC. Yes Knockdown of circIGHG led to impaired expression of IGF2BP3 and attenuated aggressiveness of OSCC cells. 33203701 circUHRF1 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells and tissue interaction[circUHRF1/miR-526b-5p/c-Myc/TGF-β1/ESRP1 feedback loop] RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//qRT-PCR//FISH//RIP//RNA-seq//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Results showed that circUHRF1 was markedly upregulated in the OSCC cells and tissue, besides, the overexpression was closely correlated with the poor prognosis of OSCC patients. In conclusion, our research identified the oncogenic roles of circUHRF1 in the OSCC tumorigenesis and EMT via circUHRF1/miR-526b-5p/c-Myc/TGF-β1/ESRP1 feedback loop, shedding light on the pathogenic mechanism of circUHRF1 for OSCC and providing the potential therapeutic target. Yes Functionally, circUHRF1 promoted the proliferation, migration, invasion, and epithelial mesenchymal transformation (EMT) in vitro and the tumor growth in vivo. 31570856 circSEPT9 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cell lines and tumour tissues regulation[miR-1225/PKN2 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this research, we found that circ_SEPT9 was highly expressed in OSCC cell lines and tumour tissues. Our study provides strong evidence that circ_SEPT9/miR-1225/PKN2 axis is a promising target for OSCC treatment. Yes Results showed that circ_SEPT9 promoted OSCC proliferation and tumour growth. 33090705 hsa_circ_009755 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and OSCC cell lines Expression[lower expressed] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The expression of hsa_circ_009755 was low in OSCC tissues and three OSCC cell lines. Yes Silencing hsa_circ_009755 significantly enhanced the proliferation, migration, and invasion and suppressed the apoptosis of OSCC cells. 32956844 circGDI2 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells regulation[MiR-424-5p/SCAI Axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Our data indicated that circGDI2 was down-regulated in OSCC, and it could be transferred by the exosomes in OSCC cells. The present study had led to the identification of exosomal circGDI2 that regulated OSCC cell malignant behaviors through targeting the miR-424-5p/SCAI axis, highlighting circGDI2 as a novel exosome-based cancer biomarker and therapeutic agent for OSCC treatment. Yes The up-regulation of exosomal circGDI2 weakened OSCC cell proliferation, migration, invasion and glycolysis. 32943917 hsa_circ_0000199 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck exosomes Expression[highly expressed] qRT-PCR Our results showed that the high level of circ_0000199 in circulating exosomes was significantly associated with betel quid chewing, tumor size, lymphatic metastasis, and TNM stage in patients with OSCC. Yes Overexpression of circ_0000199 promoted, while knockdown of circ_0000199 inhibited OSCC cell growth. 32792549 circPVT1 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells regulation[Circ-PVT1/miR-106a-5p/HK2 axis ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Circ-PVT1 was expressed with abnormal high level while miR-106a-5p was down-regulated in OSCC tissues and cells. Our works suggested that circ-PVT1 directly combined with miR-106a-5p to mediate HK2 level, consequently regulating cellular behaviors in OSCC as a tumor promoter. Yes Circ-PVT1 knockdown reduced OSCC cell growth, metastasis and glycolysis. 32737775 hsa_circ_002178 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissue regulation[Akt/mTOR pathway] CCK8//qRT-PCR Our data showed that circRNA_002178 expression in OSCC tissue specimens was remarkably higher than that in adjacent ones.CircRNA_002178, over-expressed in OSCC tissues and cell lines, may promote the malignant progression of OSCC through activating the Akt/mTOR signaling pathway. In comparison to patients in low circRNA_002178 expression group, patients in high expression group showed higher incidences of advanced pathological stage and distant metastasis, and a lower overall survival rate. Yes Cell functional experiments revealed that knockdown of circRNA_002178 markedly attenuated the proliferation and migration ability of OSCC cells compared to the sh-NC group, and the consistent results were observed in the nude mouse experiment. 32572877 circMDM2 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissue and cells interaction[miR-532-3p/HK2] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//EdU Staining Clinically, circMDM2 was overexpressed in OSCC tissue and cells, and the overexpression served as a poor prognostic factor for OSCC patients. In conclusion, these findings demonstrated that circMDM2/miR-532-3p/HK2 axis promotes the proliferation and glycolysis of OSCC, rendering a potential diagnostic biomarker and prospective therapeutic target for OSCC. Clinically, circMDM2 was overexpressed in OSCC tissue and cells, and the overexpression served as a poor prognostic factor for OSCC patients. Yes Functionally, cellular experiments confirmed that circMDM2 accelerated OSCC cell proliferation and glycolysis in vitro and circMDM2 knockdown repressed the tumour growth in vivo. 32410389 hsa_circ_0072387 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells and tissues regulation[Downregulating miR-503-5p] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay hsa_circ_0072387 expression was significantly downregulated, and miR-503-5p was upregulated in OSCC cells and tissues. hsa_circ_0072387 inhibited OSCC progression by downregulating miR-503-5p, explicating that hsa_circ_0072387 could function as a novel potential therapeutic target for OSCC. Yes Gain of hsa_circ_0072387 or knockdown of miR-503-5p suppressed the cell proliferation, migration and invasion, EMT, and glycolysis in OSCC SCC-4 and HSC-3 cells. 32302508 hsa_circ_0001971 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck tumor tissues and cell lines Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay The expression of circ_0001971 was significantly increased in tumor tissues and cell lines. Yes Circ_0001971 knockdown inhibited cell proliferation, migration, and invasion but promoted cisplatin (DDP) sensitivity and cell apoptosis. 32196598 hsa_circ_0055538 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Oral squamous cell carcinoma tissues Regulation[p53/Bcl-2/caspase signaling pathway] CCK8//Wound Healing Assay//EdU Staining//Western Blot Low hsa_circ_0055538 expression levels were verified in tumor tissues and OSCC cell lines.Importantly, nude mouse experiments showed that high expression of hsa_circ_0055538 inhibited tumor growth. Finally, hsa_circ_0055538 may affect the development of OSCC via the p53/Bcl-2/caspase signaling pathway. Clinical data analysis showed that the expression level is related to the degree of tumor differentiation. Yes Lentiviral infection and siRNA transfection of SCC9 and CAL27 cell lines revealed that changes in circRNA expression significantly affected the malignant biological behavior of OSCC cells. 30857544 hsa_circ_0004491 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC and normal tissue Expression[Expression[lower expressed]-expression] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay qRT-PCR analysis revealed that hsa_circ_0004491 was significantly Expression[down-expression]regulated in OSCC tissues compared with paired normal tissues (P < 0.001), and this low expression was associated with lymph node metastasis (P = 0.0398; area under ROC curve = 0.7510). Yes Hsa_circ_000449 silencing or overexpression significantly affected the invasion and migration abilities of OSCC cells. 31669576 circSPATA6 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells Interaction( miR-182) qRT-PCR CircSPATA6 and TRAF6 were declined, and miR-182 was elevated in OSCC cells. Mechanistically, circSPATA6 could modulate TRAF6 expression through sponging miR-182. Yes Functionally, circSPATA6 impeded migration and invasion, and facilitated cell cycle arrest and apoptosis of OSCC cells. 33654430 circCEP128 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cells Interaction(microRNA-515-5p/SDC1 Axis) qRT-PCR//MTT//Western Blot circCEP128 and SDC1 were highly expressed and miR-515-5p was low expressed in bladder cancer tissues and cells. circCEP128 loss increased miR-515-5p expression through direct interaction in bladder cancer cells. MiR-515-5p depletion mitigated the influences of circCEP128 knockdown on bladder cancer cell phenotypes. SDC1 was a direct target of miR-515-5p. circCEP128 positively regulated SDC1 expression via miR-515-5p. Yes circCEP128 knockdown hindered cell proliferation, migration and invasion and promoted cell apoptosis in bladder cancer. 33833571 circMYLK CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cells Interaction(miR-34a/CCND3 ) qRT-PCR//Western Blot CircMYLK was highly expressed in bladder cancer tissues and cells.CircMYLK contributed to the malignant development of bladder cancer cells partly through the miR-34a/CCND3 regulatory network, showing the significance of circMYLK in bladder cancer pathogenesis. Yes CircMYLK downregulation inhibited bladder cancer cell migration and invasion, and promoted cancer cell apoptosis and cell cycle arrest. 34056735 hsa_circ_0088036 CircRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cell lines Interaction(miR-140-3p/FOXQ1 signaling) qRT-PCR//RIP Upregulated expression of hsa_circRNA_0088036 in BCa tissues and cell lines was positively correlated with overall survival and clinicopathologic characteristics. Mechanistically, hsa_circRNA_0088036 could directly interact with miR-140-3p and act as a miRNA sponge to modulate FOXQ1 expression. Knockdown of hsa_circRNA_0088036 inhibited the proliferation, migration, and metastasis of BCa cells via miR-140-3p/FOXQ1 signaling. Upregulated expression of hsa_circRNA_0088036 in BCa tissues and cell lines was positively correlated with overall survival and clinicopathologic characteristics. Yes Knockdown of hsa_circRNA_0088036 inhibited the growth, migration, and invasion of BCa cells both in vivo and in vitro. 35396504 circLAMA3 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cell lines Interaction(MYC/CDK6) qRT-PCR//Western Blot The circular RNA (circRNA) circLAMA3 is significantly downregulated in bladder cancer tissues and cell lines. Mechanistically, circLAMA3 directly binds to and promotes the degradation of MYCN mRNA, thereby reducing the MYCN protein expression in bladder cancer cells. Decreased expression of the MYCN protein inhibits the promoter activity and expression of CDK6. Ultimately, circLAMA3 affects DNA replication by downregulating CDK6, resulting in G0/G1 phase arrest and inhibition of bladder cancer proliferation. Yes In this study, functional experiments demonstrated that circLAMA3 significantly inhibited the proliferation, migration, and invasion of bladder cancer cells and inhibited bladder cancer growth in vivo. 35317525 hsa_circ_3323 CircRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues Interaction(miR-186-5p/APP axis) qRT-PCR//RNA Pull-Down The expression of circ3323 was higher in BCa tissues and cells than in normal samples. Mechanistically, we demonstrated that circ3323 acts as a sponge for miR-186-5p and promotes host gene APP's expression. miR-186-5p/APP axis Yes Experiments in vitro showed that the knockdown of circ3323 inhibited cell proliferation and impeded the metastasis of BCa cells. 35362879 circFARSA CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines Interaction(microRNA-330-5p) qRT-PCR//Western Blot circFARSA expression was markedly upregulated in BC tissues and cell lines compared with that in normal bladder samples. Downregulating circFARSA expression slowed tumor growth in vivo and directly sponged miR-330 and inhibited its function in BC cells in vitro. Inhibiting miR-330 expression abolished the regulatory effects of circFARSA silencing on the tumor phenotypes of BC cells. Yes Silencing circFARSA expression decreased BC cell proliferation, invasion, and migration but induced their apoptosis in vitro. 35395756 circNCOR1 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction(DDX39B/TGFβ-SMAD ) ISH Here, we identify an intron-retained circRNA, circNCOR1, that is significantly downregulated in LN metastatic bladder cancer and is negatively associated with poor prognosis of patients.Nuclear retention of circNCOR1 was regulated by small ubiquitin-like modifier (SUMO)ylation of DDX39B, an essential regulatory factor responsible for circRNA nuclear-cytoplasmic transport. Reduced SUMO2 binding to DDX39B markedly increased circNCOR1 retention in the nucleus to suppress bladder cancer LN metastasis. Here, we identify an intron-retained circRNA, circNCOR1, that is significantly downregulated in LN metastatic bladder cancer and is negatively associated with poor prognosis of patients. Yes Overexpression of circNCOR1 inhibited lymphangiogenesis and LN metastasis of bladder cancer in vitro and in vivo. 35395674 circPTK2 CircRNA Homo sapiens Urinary Bladder Neoplasms Bca cell lines Interaction(circPTK2/PABPC1/SETDB1 axis) Western Blot//ISH//Bioinformatics Analysis//Transfection//qRT-PCR//RIP//FISH//PCR//IP//IHC//Invasion Assay//IF Herein, we identified an upregulated circRNA, circPTK2, which could regulate SETDB1 expression by analyzing the transcriptome by RNA-sequencing.Importantly, using circRNA pulldown assay and RNA-binding protein immunoprecipitation, we identified PABPC1 as a robust novel interacting protein of circPTK2. Mechanistically, circPTK2 could bind to PABPC1 and enhance its ability to stabilize SETDB1 mRNA, thereby specifically promoting SETDB1 expression and facilitating SETDB1-mediated epithelial-mesenchymal transition (EMT). Yes Functionally, overexpression of the circPTK2-SETDB1 axis markedly promoted migration, invasion, and gemcitabine resistance in vitro and enhanced lymph node metastasis in vivo. 36436682 circSPECC1 CircRNA Homo sapiens Urinary Bladder Neoplasms Bca tissues and cell lines. Interaction(miR-136-5p/GNAS axis) qRT-PCR//RNA Pull-Down In this study, we found that circSPECC1 was significantly up-regulated in Bca tissues and cell lines. Mechanically, circSPECC1 sponged miR-136-5p to promote the mRNA and protein expression of GNAS. Besides, enforced expression of GNAS significantly reversed the proliferation and migration inhibition mediated by circSPECC1 suppression. Increased expression of circSPECC1 contribute to poor prognosis of Bca. Yes Further tests showed that knockdown of circSPECC1 impaired the proliferation and migration of Bca cells. 35523104 circSTK39 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cell lines Interaction(miR-135a-5p/NR3C2) qRT-PCR//Wound Healing Assay//Transwell Assay In this research, we first found a novel circRNA, circSTK39 (termed as has_circ_0001079), which was a downregulated gene based on the results of high-throughput RNA sequencing. Subsequently, we determined that the expression of circSTK39 in BCa tissues and their cell lines was significantly reduced. In conclusion, our results revealed that circSTK39 inhibited EMT of BCa cells through the miR-135a-5p/NR3C2 axis and may provide promising biomarkers for the diagnosis or prospective therapeutic targets for BCa. In addition, lower circSTK39 expression was strongly related to a worse prognosis for BCa patients. Yes Next, we detected the biological functions of circSTK39 by using loss and gain experiments in vitro and in vivo. Ectopic expression of circSTK39 decreased cell proliferation, colony formation, and invasion capacities, while circSTK39 knockdown prevented the above phenotypes. 36538242 circSHPRH CircRNA Homo sapiens Urinary Bladder Neoplasms BCa cells and tissues Interaction(miR-942/BARX2 pathway) qRT-PCR//Luciferase Report Assay In this article, we showed that circSHPRH expression was obviously decreased in BCa tissues, compared with adjacent normal tissues. Mechanistic studies demonstrated that circSHPRH could combine with miR-942 and serve as a sponge of miR-942, which targets BARX2 in BCa cells. Rescue experiments showed that suppression of miR-942 or BARX2 overexpression could significantly abrogate the promoting effects of circSHPRH silencing on BCa cell proliferation and invasion. Furthermore, circSHPRH overexpression partly eliminated the suppressive effects of miR-942 on BARX2 expression. In addition, circSHPRH knockdown promoted activation of the Wnt/β-catenin signaling pathway by regulating BARX2. Moreover, a low circSHPRH level was positively correlated with a high grade, a high pathological stage, lymphatic metastasis and an unfavorable prognosis for BCa patients. Yes Cell function studies indicated that silencing circSHPRH dramatically increased the proliferation, migration and invasion of BCa cells. 35200157 hsa_circ_0000658 CircRNA Homo sapiens Urinary Bladder Neoplasms BCa tissue samples and cell lines Interaction(miR-498/HMGA2 axis) qRT-PCR//FISH Circ_0000658 was highly expressed in BCa tissue samples and cell lines, which indicated a poor prognosis of BCa patients. Circ_0000658 competitively bound to miR-498 and thus restricted miR-498 expression. Meanwhile, circ_0000658 weakened the binding of miR-498 to the target gene HMGA2 and upregulated the HMGA2 expression. Circ_0000658 was highly expressed in BCa tissue samples and cell lines, which indicated a poor prognosis of BCa patients. Yes Circ_0000658 elevation or miR-498 knockdown augmented oncogenic phenotypes and EMT of BCa cells, corresponding to a reduction in the expression of β-catenin and E-cadherin as well as an increase in the expression of N-cadherin, Slug, Snail, ZEB1 and Twist. Inhibition of HMGA2 reversed the effects of circ_0000658 overexpression on tumor growth in vivo. 35031054 hsa_circ_0139402 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Interaction(hsa-miR-326/PAX8 Signaling) qRT-PCR//Western Blot High-throughput sequencing result showed that the expression of hsa_circ_0139402 was highest in BC tissues and increased in metastatic tissues compared to that of nonmetastatic tissues.Bioinformatics analysis, dual-luciferase reporter, and RIP assay showed that hsa_circ_0139402 can bind to hsa-miR-326, and PAX8 is a direct target of hsa-miR-326 in BC cell. Yes MTT assay, wound healing assay, and transwell assay revealed that sh-hsa_circ_0139402 could suppress BC cells' proliferation, invasion, and migration. Further, cytological studies found that hsa_circ_0139402 enhances BC cells' proliferation, migration, and invasion by targeting PAX8 via hsa-miR-326. 35154515 hsa_circ_0002099 CircRNA Homo sapiens Urinary Bladder Neoplasms BLCA tissues and cells Interaction(miR-217-5p/miR-103a-3p/KRAS axis-WNT/β-catenin axis) CCK8//qRT-PCR//Luciferase Report Assay The results indicated that Circ_0002099 was significantly upregulated in BLCA and could enhance the progression of BLCA in vivo and in vitro. Furthermore, dual-luciferase reporter assay and FISH assay revealed that Circ_0002099 could regulate miR-217-5p/miR-103a-3p/Kirsten RAS (KRAS) axis in BLCA. In addition, rescue experiments confirmed that miR-217-5p/miR-103a-3p could rescue the facilitative effect of Circ_0002099 on BLCA progression. Yes The results indicated that Circ_0002099 was significantly upregulated in BLCA and could enhance the progression of BLCA in vivo and in vitro. 36301978 hsa_circ_0000515 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines Interaction(miR-542-3p/ILK axis) qRT-PCR//Luciferase Report Assay//Western Blot Circ_0000515 and ILK expressions were significantly elevated in BC tissues and cell lines, while that of miR-542-3p was dramatically suppressed. Moreover, circ_0000515 knockdown inhibited pulmonary metastasis in vivo. Circ_0000515 was validated to adsorb miR-542-3p, and ILK was testified as the downriver target of miR-542-3p. Circ_0000515 could ascend ILK expression through repressing that of miR-542-3p. Yes Knocking down circ_0000515 could significantly repress the growth, migration and aggressiveness of BC cells while overexpression of circ_0000515 showed opposite effects. 35029589 circZNF609 CircRNA Homo sapiens Urinary Bladder Neoplasms BCa cell lines and tissues Interaction(miR-1200/CDC25B pathway) qRT-PCR//FISH CircZNF609 expression was increased significantly in BCa cell lines and tissues. Mechanistically, circZNF609 alleviated the inhibition effect on target CDC25B expression by sponging miR-1200. CircZNF609 promoted tumor growth through novel circZNF609/miR-1200/CDC25B axis, implying that circZNF609 has significant potential to act as a new diagnostic biomarker and therapeutic target in BCa. For BCa patients, increased expression of circZNF609 was correlated with a worse survival. Yes In vitro and in vivo, enforced expression of circZNF609 enhanced BCa cells proliferation, migration, and cisplatin chemoresistance. 35567596 circDHTKD1 CircRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cell line Regulation(CXCL5) qRT-PCR//IHC Mechanistically, circDHTKD1 directly interacted with miR-149-5p, and antagonized the repression of miR-149-5p on CXCL5. Furthermore, circDHTKD1-induced CXCL5 expression recruited and activated neutrophils, which participated in lymphangiogenesis by secreting VEGF-C. Our study supports circDHTKD1 as a promising diagnostic and therapeutic target for LN metastasis in BCa. Yes By analyzing the co-expression patterns of circDHTKD1 and differentially expressed mRNAs, we identified that circDHTKD1 facilitated lymphangiogenesis by upregulating CXCL5. 35504887 hsa_circ_0003221 CircRNA Homo sapiens Urinary Bladder Neoplasms BLCA cells Interaction(miR-892b/DHCR24 ) qRT-PCR//RNA Pull-Down Abnormal circ_0003221 upregulation was affirmed in BLCA. MiR-892b was identified as a target for circ_0003221. Reduction of miR-892b relieved si-circ_0003221-induced anti-tumor response in BLCA cells. In addition, miR-892b targeted DHCR24 and circ_0003221/miR-892b could regulate the level of DHCR24. The effects of si-circ_0003221 were also counteracted by DHCR24 overexpression. Yes BLCA cell proliferation, motility and glycolysis were impeded after circ_0003221 level was knocked down. 36068004 hsa_circ_0002623 CircRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cell line Interaction(miR-1276/SMAD2 axis) qRT-PCR//Transwell Assay We reported that, in BCa tissues and cell lines, circ_0002623 was upregulated, whereas miR-1276 was downregulated. Additionally, circ_0002623 could competitively bind with miR-1276 to increase the expression of SMAD2, the target gene of miR-1276. Furthermore, circ_0002623 could regulate the expression of TGF-β and WNT1 via modulating miR-1276 and SMAD2. Yes Circ_0002623 positively regulated BCa cell proliferation, migration, and cell cycle progression. 35048477 circFOXO3 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck  OSCC tumor and cell lines Interaction( miR-214) In Vivo Experiment//Western Blot//CCK8//RIP//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis CircRNA sequencing was conducted in OSCC tumor and tumor-side tissues, and the expression of circFOXO3 is found to be markedly increased in tumor tissues. CircFOXO3 is also highly expressed in several OSCC cell lines compared with human oral keratinocytes. Yes Transwell assay and colony formation showed that knockdown of circFOXO3 prevents the invasion and proliferation of oral cancer cells. Via bioinformatic research, miR-214 was found to be the target of circFOXO3 and correlate well with circFOXO3 both in vitro and in vivo. KDM2A was then validated by database analysis and luciferase assay to be the direct target of miR-214.  34117688 circMTO1 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tumor tissues and cells Interaction(miR-320a) RNA Pull-Down//ChIP//Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay It was found that circMTO1 was upregulated in OSCC tumor tissues and cells. A novel circMTO1/miR-320a/ATRX axis was identified. Our results suggest that circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a. Yes It was found that circMTO1 knockdown inhibited OSCC cell proliferation, migration, and invasion. 34738503 hsa_circ_0000052 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Interaction(miR-382-3p/PD-L1 axis) qRT-PCR//Western Blot//FISH Our data demonstrate that circ_0000052 is oncogenic, and the circ_0000052/miR-382-3p/PD-L1 axis is critical in HNSCC progression. Yes In addition to demonstrating that the IFN-γ/JAK2/STAT1 signalling pathway can induce PD-L1 overexpression in HNSCC, a novel mechanism by which upregulated circ_0000052 mediates PD-L1 overexpression was also demonstrated. To do this, circ_0000052 competitively binds to miR-382-3p and alleviates its repression of PD-L1. This leads to overexpression of PD-L1, causing the aggressiveness of the cells. 36515567 hsa_circ_0004872 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(miR-424-5p) qRT-PCR//Western Blot//RIP//Transwell Assay The expression of circ_0004872 was significantly downregulated in OSCC tissues and cells, and the overexpression of circ_0004872 inhibited the proliferation, vitality, invasion, and glycolysis of OSCC cells, and promoted apoptosis. The expression of miR-424-5p was greatly upregulated in OSCC tissues and OSCC cells. circ_0004872 can adsorb miR-424-5p in OSCC cells, and circ_0004872 can reverse the promoting effect of miR-424-5p overexpression on the process of OSCC cells. Yes The expression of circ_0004872 was significantly downregulated in OSCC tissues and cells, and the overexpression of circ_0004872 inhibited the proliferation, vitality, invasion, and glycolysis of OSCC cells, and promoted apoptosis. 35576499 circZDBF2 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells Interaction(miR-362-5p and miR-500b-5p/RNF145/CEBPB) CCK8//qRT-PCR//Colony Formation Assay CircZDBF2 expressed at a high level in OSCC cells and it accelerated OSCC cell proliferation, migration, invasion as well as EMT (epithelial-mesenchymal transition) process. Further, circZDBF2 sponged miR-362-5p and miR-500b-5p in OSCC cells to release their target ring finger protein 145 (RNF145). RNF145 expressed at a high level in OSCC cells and circZDBF2 facilitated RNF145 transcription by recruiting the transcription factor CCAAT enhancer binding protein beta (CEBPB). Moreover, RNF145 activated NFκB (nuclear factor kappa B) signaling pathway and regulated IL-8 (C-X-C motif chemokine ligand 8) transcription. Yes CircZDBF2 expressed at a high level in OSCC cells and it accelerated OSCC cell proliferation, migration, invasion as well as EMT (epithelial-mesenchymal transition) process. 35365168 hsa_circ_0014359 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction(miR-149) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay We found that circ_0014359 was highly expressed in the OSCC tissues and cell lines compared to the normal controls (P<0.05). The circ_0014359 can directly interact with the micro-RNA-149 (miR-149). Inhibition of miR-149 can rescue the inhibitory effects of circ_0014359 knock down on OSCC cells. The expression of circ_0014359 was associated with the survival of patients (P<0.05). Yes For the OSCC cell lines, circ_0014359 knock down induced apoptosis and inhibited migration, invasion, and epithelial-mesenchymal transition of OSCC cells (P<0.001). In vivo, silencing the circ_0014359 blocked the growth of OSCC tumors. 35612554 hsa_circ_0005320 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(circ_0005320-miR-486-3p/miR-637 axis ) CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Circ_0005320 expression was higher in OSCC tissues and cells. Mechanistically, miR-486-3p or miR-637 were confirmed to be a target of circ_0005320. Moreover, the inhibitory effects of circ_0005320 silencing on OSCC growth were reversed by the inhibition of miR-486-3p or miR-637. We also found that circ_0005320-miR-486-3p/miR-637 axis mediated the activation of JAK2/STAT3 pathway. Yes Knockdown of circ_0005320 suppressed OSCC cell growth, migration, invasion, and induced cell apoptosis in vitro, as well as impeded tumor growth in vivo. 34967281 circCLK1 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC patients and cell lines Interaction(miR-18b-5p/Y-box protein 2 axis) Flow Cytometry//qRT-PCR//Western Blot We found that the expression of circ-CLK1 was significantly higher in OSCC patients and cell lines.However, inhibiting miR-18b-5p or overexpression of Y-box protein 2 (YBX2) can reverse the effect of circ-CLK1 knockdown on OSCC cells. Therefore, circ-CLK1 inhibited the apoptosis of OSCC cells through the miR-18b-5p/YBX2 axis, and these findings suggest that circ-CLK1 could be a potential therapeutic target for OSCC patients. Yes Inhibition of circ-CLK1 reduced the viability and proliferation of OSCC cells while enhancing their apoptosis. 35156507 circGOLPH3 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and normal paracancerous tissues Interaction(miR-145-5p/lysine demethylase 2A (KDM2A) axis) qRT-PCR//Western Blot circGOLPH3 expression was upregulated in OSCC. circGOLPH3 downregulation inhibited cell growth, metastasis, and glycolysis in vitro, and in vivo experiments revealed that circGOLPH3 inhibited tumor growth. In addition, circGOLPH3 bound to miR-145-5p and competitively inhibited KDM2A expression, thereby regulating OSCC cell behaviors as well as glycolysis. Yes Knockdown of circGOLPH3 inhibited OSCC cell malignant phenotypes and glycolysis 36268878 circMYBL2 CircRNA Homo sapiens pancreatic adenocarcinoma PA tissues and cells Interaction(miR-19a ) qRT-PCR//Wound Healing Assay//Transwell Assay Downregulation of circ-MYBL2 and upregulation of miR-19a were observed in PA. In conclusion, circ-MYBL2 was downregulated in PA and it downregulated miR-19a through methylation to suppress PA cell proliferation. Yes In PA cells, circ-MYBL2 decreased the accumulation of miR-19a but increased its RNA gene methylation. Overexpression of circ-MYBL2 decreased PA cell proliferation and movement, while overexpression of miR-19a showed an opposite effect. In addition, circ-MYBL2 suppressed the role of miR-19a in cell proliferation, migration, and invasion. 35387554 hsa_circ_0002577 CircRNA Homo sapiens Endometrial Neoplasms EC tissues Regulation[regulating miR-197/CTNND1 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Here, we showed that hsa_circ_0002577 expression was significantly Expression[Expression[up-expression]-expression]regulated in EC tissues.In mechanism study, we revealed that hsa_circ_0002577 might act as a sponge for miR-197, and CTNND1 was revealed to be a target gene of miR-197. In addition, we revealed that the oncogenic effects of hsa_circ_0002577 were attributed to the regulation of miR-197/CTNND1/Wnt/β-catenin axis. and high hsa_circ_0002577 expression was associated with advanced FIGO stage, lymph node metastasis, and poor overall survival rate of EC patients. Yes In function assays, we demonstrated that hsa_circ_0002577 knockExpression[down-expression] significantly reduced EC cells proliferation, migration, invasion ability in vitro and decreased tumor growth in vivo. 31081718 hsa_circ_0075960 CircRNA Homo sapiens Endometrial Neoplasms cell lines regulation[miR-361-3p/SH2B1] CCK8//qRT-PCR//Wound Healing Assay//Luciferase Report Assay We first determined that hsa_circ_0075960 is aberrantly expressed in EC cells.Our cumulative results revealed that the novel tumor regulator hsa_circ_0075960 functioned as a sponge for miR-361-3p/SH2B1 in EC cells and regulated the progression of EC through the modulation of miR-361-3p. Yes Then, we uncovered that the downregulation of hsa_circ_0075960 suppressed cell proliferation and promoted cell apoptosis of EC cells, suggesting that hsa_circ_0075960 could inhibit the progression of EC in vitro. 33356989 hsa_circ_0109046 CircRNA Homo sapiens Endometrial Neoplasms EC tissues,cell line regulation[microRNA-105/SOX9/Wnt/β-catenin axis] qRT-PCR First, high expression of Circ_0109046 was found in EC tissues compared to the adjacent tissues, and it predicted unfavorable prognosis in patients. Similarly, high expression of Circ_0109046 was confirmed in EC cells relative to that in normal endometrial epithelial cells.This study evidenced that Circ_0109046 upregulates SOX9 expression through sponging miR105, leading to activation of Wnt/β-catenin signaling and the malignant growth of EC. This study may offer novel understanding in EC treatment. Yes Silencing of Circ_0109046 in AN3-CA cells inhibited proliferation and aggressiveness but increased apoptosis of cells. 33220169 hsa_circ_0067835 CircRNA Homo sapiens Endometrial Neoplasms endometrial tissues interaction[sponges miR-324-5p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay We observed circ_0067835 was markedly elevated in endometrial cancer. In conclusion, circ_0067835 can compete with miR-324-5p, resulting in HMGA1 up-regulation, and therefore induce the development of endometrial cancer. Yes Loss-of-functional assays revealed that circ_0067835 down-regulation significantly repressed RL95-1 and HEC-1B cell proliferation, migration and invasion. 33169939 hsa_circ_0000043 CircRNA Homo sapiens Endometrial Neoplasms EC tissues and cells regulation[miR-1271-5p/CTNND1 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Circ_0000043 and CTNND1 were highly expressed and miR-1271-5p was lowly expressed in EC tissues and cells.Circ_0000043 knockdown inhibited the progression of EC by regulating miR-1271-5p/CTNND1 axis, which might provide a promising circRNA-targeted therapy for EC. Yes Knockdown of circ_0000043 inhibited the progression of EC by inhibiting cell proliferation, migration, invasion and tumor growth (in vivo) and promoting apoptosis. 33128584 circTNFRSF21 CircRNA Homo sapiens Endometrial Neoplasms EC cells and tumor tissues regulation[miR-1227-MAPK13/ATF2 axis] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Colony Formation Assay In this study, we found that circTNFRSF21 was highly expressed in EC cells and tumor tissues. Mechanically, we showed that circTNFRSF21 acts as a sponge of miR-1227 in EC cells to rescue MAPK13/ATF2 signaling pathway activity. Yes In vitro and in vivo results showed that circTNFRSF21 was linked to increased EC cell growth and EC xenografts formation in nude mice. 32299063 hsa_circ_0001610 CircRNA Homo sapiens Endometrial Neoplasms EC samples (n = 30) and cells Interaction(miR-646-STAT3 axis) qRT-PCR//Wound Healing Assay//Colony Formation Assay//Transwell Assay circ_0001610 levels were upregulated in EC samples (n = 30) and cells. miR-646 is targeted by circ_0001610, and miR-646 inhibition attenuated interference of circ_0001610-mediated suppression of EC development. STAT3 was modulated by miR-646, and miR-646 upregulation restrained EC progression by decreasing STAT3. circ_0001610 silencing reduced STAT3 levels by sponging miR-646 and reduced the growth of xenograft tumor established by EC cells. Yes circ_0001610 interference restrained cell proliferation, migration, and invasion, and promoted apoptosis. circ_0001610 downregulation constrained glycolysis through reducing glucose consumption, lactate production, and levels of adenosine triphosphate, extracellular acidification, hexokinase 2, and lactate dehydrogenase A, and increasing oxygen consumption rate. 33822442 hsa_circ_0075960 CircRNA Homo sapiens Endometrial Neoplasms EC tissues Interaction(miR-202-5p/CTNND1 axis/Wnt/β-catenin) qRT-PCR//Wound Healing Assay//Western Blot Circ_0075960 and CTNND1 were upregulated, while miR-202-5p was downregulated in EC. MiR-202-5p was targeted by circ_0075960 and it directly bound to CTNND1 3'UTR. The inhibition of circ_0075960 knockdown or miR-202-5p enrichment on EC cell proliferation and migration was reversed by miR-202-5p depletion or CTNND1 overexpression, respectively. Circ_0075960 targeted miR-202-5p to positively regulate CTNND1 expression. Moreover, circ_0075960 knockdown weakened the activity of Wnt/β-catenin signaling via targeting the miR-202-5p/CTNND1 axis. Yes Knockdown of circ_0075960 induced EC cell apoptosis, suppressed cell proliferation and migration, and repressed tumor growth in animal models. 36424704 circWDR26 CircRNA Homo sapiens Endometrial Neoplasms EC tissues or cell lines Interaction(miR-212-3p/MSH2 axis) qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay The expression of circWDR26 in EC tissues or cell lines was higher than in the normal tissue or endometrial epithelial cells. Mechanistically, circWDR26 targeted and suppressed the expression of miR-212-3p. We further found that MSH2 was the novel target of miR-212-3p and was upregulated by circWDR26 via inhibiting miR-212-3p. In vivo experiment demonstrated that circWDR26 was essential for EC tumor growth. Yes Downregulation of circWDR26 resulted in attenuated proliferation, increased apoptosis, reduced migration and invasion of EC cells. 35897048 hsa_circ_0000437 CircRNA Homo sapiens Endometrial Neoplasms EC tissues ands cells Interaction(miR-626/CDKN1B Axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Circ_0000437 expression was reduced in EC tissues, and the low expression of circ_0000437 was positively correlated with the lymph node metastasis and high TNM stage of EC patients. Circ_0000437 directly targeted miR-626 and negatively modulated miR-626 expression in EC cells. CDKN1B was identified as the downstream target of miR-626 in EC cells. Besides, CDKN1B overexpression of miR-626 knockdown reversed the effects of knocking down circ_0000437 on EC cells. Yes Knocking down circ_0000437 promoted the proliferation, invasion and EMT of EC cells. 35733309 circGNG7 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues andCAL27, CAL33, SCC4, SCC9, HN6, and HN30 cells Interaction(HSP27-JNK/P38 MAPK signaling) qRT-PCR CircGNG7 was predominately localized to the cytoplasm, and its expression was downregulated in both HNSCC tissues andCAL27, CAL33, SCC4, SCC9, HN6, and HN30 cells. Our results revealed that a new intronic circRNA, circGNG7, functions as a strong tumor suppressor and that circGNG7/HSP27-JNK/P38 MAPK signaling is a novel mechanism by which HNSCC progression can be controlled. Low expression of circGNG7 was significantly correlated with poor prognosis in HNSCC patients. Yes Consistent with this finding, overexpression of circGNG7 strongly inhibited tumor cell proliferation, colony formation, in vitro migration, and in vivo tumor growth. 34498800 circOSBPL10 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(miR-299-3p/CDK6 axis) qRT-PCR//Luciferase Report Assay//Western Blot Circ_OSBPL10 was up-regulated in OSCC tissues and cells. Mechanistically, circ_OSBPL10 directly targeted miR-299-3p, and circ_OSBPL10 silencing affected cell functional properties in vitro by up-regulating miR-299-3p. CDK6 was a direct and functional target of miR-299-3p. The circ_OSBPL10/miR-299-3p axis regulated cell functional properties in vitro via CDK6. Yes Silencing of circ_OSBPL10 hindered cell proliferation, cell cycle progression, colony formation, migration, invasion, and promoted apoptosis in vitro and diminished tumor growth in vivo. 35180547 hsa_circ_0076977 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction(miR-802/MYO6) qRT-PCR//Western Blot//Colony Formation Assay//Transwell Assay Circular (circ)_0076977 was abnormally up-regulated in OSCC tissues and cell lines. miR-802 was a direct target of circ_0076977, and circ_0076977 knockdown restrained OSCC progression largely by up-regulating miR-802. miR-802 directly interacted with myosin VI (MYO6) mRNA, and MYO6 was negatively modulated by miR-802 in OSCC cells. miR-802 overexpression reduced the malignant potential of OSCC cells largely by down-regulating MYO6. Circ_0076977 could up-regulate MYO6 expression by absorbing miR-802 in OSCC cells. Yes Circ_0076977 absence inhibited the proliferation, angiogenesis, migration, and invasion and induced the apoptosis of oral squamous cell carcinoma (OSCC) cells. Circ_0076977 knockdown blocked xenograft tumor growth. 36265392 circGDI2 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(miR-454-3p/FOXF2 Axis) qRT-PCR CircGDI2 was a stable circRNA and was low expressed in OSCC tissues and cells. MiR-454-3p could be sponged by circGDI2, and its overexpression could mitigate the suppressive effects of circGDI2 overexpression on OSCC progression. Meanwhile, circGDI2 positively regulated FOXF2 expression by targeting miR-454-3p. Yes CircGDI2 overexpression could effectively inhibit the proliferation, migration, invasion and promote apoptosis in OSCC cells, and suppress OSCC tumor growth in nude mice in vivo. 33603482 circPVT1 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(miR-143-3p/SLC7A11 axis ) Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay CircPVT1 and SLC7A11 were upregulated, while miR-143-3p was downregulated in OSCC tissues and cells. CircPVT1 upregulated SLC7A11 expression via sponging miR-143-3p. SLC7A11 upregulation alleviated the effect of circPVT1 knockdown on OSCC cell progression. Besides, circPVT1 modulated MAPK signaling pathway by regulating miR-143-3p. Yes Silencing of circPVT1 or SLC7A11 suppressed proliferation, migration, and invasion and promoted apoptosis in OSCC cells. 35624316 circKIAA0907 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 59 paired OSCC cancer tissues and adjacent normal tissues Interaction(miR-96-5p/UNC13C axis) qRT-PCR//RNA Pull-Down//RIP//Western Blot Circ-KIAA0907 was a stability circRNA with lowly expression in OSCC. In the terms of mechanism, circ-KIAA0907 could sponge miR-96-5p to regulate UNC13C expression. MiR-96-5p overexpression could reverse the inhibitory effect of circ-KIAA0907 on OSCC progression, and UNC13C knockdown also could overturn the suppressive effect of miR-96-5p inhibitor on OSCC progression. Animal experiments revealed that circ-KIAA0907 could reduce the tumor growth of OSCC by regulating the miR-96-5p/UNC13C axis. Yes Overexpressed circ-KIAA0907 could inhibit migration, invasion, and glycolysis, while promoting apoptosis and radiosensitivity in OSCC cells. 33715625 circLPAR3 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(miR-643/HMGB2 Network) qRT-PCR//Western Blot Our data showed that circLPAR3 was highly expressed in OSCC tissues and cells.On the mechanism, we discovered that circLPAR3 could sponge miR-643 to positive regulate HMGB2. MiR-643 overexpression had an inhibition effect on OSCC progression, and its inhibitor could reverse the negative regulation of circLPAR3 knockdown on OSCC progression. In addition, overexpressed HMGB2 also reversed the suppressive effect of circLPAR3 silencing on OSCC progression. Yes CircLPAR3 silencing suppressed OSCC cell proliferation, metastasis and stemness, while promoted apoptosis. 34528144 hsa_circ_0004674 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Interaction(microRNA-377-3p/THBS1 axis) qRT-PCR//RIP Circ_0004674 and THBS1 levels were enhanced while miR-377-3p level was reduced in OSCC. Down-regulating Circ_0004674 restricted the growth of CAL27 cells in vivo and in vitro. Restoring miR-377-3p, the target gene of Circ_0004674, destroyed CAL27 cell progression and tumor growth. miR-377-3p suppression rescued the effects of down-regulated Circ_0004674 on OSCC. THBS1 was negatively mediated by miR-377-3p. Yes Down-regulating Circ_0004674 restricted the growth of CAL27 cells in vivo and in vitro. 33621591 hsa_circ_0036988 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression(lower expressed) CCK8//qRT-PCR Hsa_circ_0036988 was significantly downregulated in OSCC tissues compared with adjacent normal tissues. Furthermore, the altered expression of hsa_circ_0036988 have an impact on the epithelial-to-mesenchymal transition (EMT)-related protein expression levels. While low expression of hsa_circ_0036988 was highly correlated with lymph nodes metastasis. Yes Overexpression or knockdown of hsa_circ_0036988 significantly affected the proliferation, migration and invasion of OSCC cells. 33896837 circKRT1 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Interaction(miR-495-3p/PDL1 axis) qRT-PCR//RNA Pull-Down//RIP//Western Blot CircKRT1 and PDL1 were highly expressed in OSCC tissues and cells. CircKRT1 sponged miR-495-3p and miR-495-3p targeted PDL1. OSCC progression and immune evasion were regulated by circKRT1 via the miR-495-3p/PDL1 axis. CircKRT1 also facilitated OSCC progression in vivo by regulating miR-495-3p and PDL1. Yes CircKRT1 knockdown repressed OSCC cell growth, migration, invasion, epithelial-mesenchymal transition, and CD8+ T-cell apoptosis, but enhanced CD8+ T cytotoxicity and percentage. The inhibitory effects of circKRT1 downregulation on OSCC progression and immune evasion were related to PDL1 expression inhibition. 33675276 circBCL11B CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction(miR-579/LASP1 axis) CCK8 We demonstrated that circBCL11B was significantly upregulated in OSCC tissues and cell lines, and the expression level was correlated with the malignancy. miR-145 was identified as a downstream target mediating the effect of circBCL11B by targeting LASP1. miR-145 negatively regulated LASP1 expression, which could be rescued by miR-145 inhibitor. Collectively, our study uncovered a functional role of circBCL11B/miR-579/LASP1 axis in OSCC. We demonstrated that circBCL11B was significantly upregulated in OSCC tissues and cell lines, and the expression level was correlated with the malignancy. Yes Silencing cirCBCL11B inhibited cell proliferation and migration, and also included cell apoptosis in OSCC cells. 34288804 hsa_circ_0060927 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck NOM, OLK, and OSCC Interaction(miR-195-5p/TRIM14 axis) RNA Pull-Down//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The expression of hsa_circ_0060927 increased in NOM, OLK, and OSCC. The prediction of ceRNA network suggested that hsa_circ_0060927 could regulate the target gene TRIM14 through sponging miR-195-5p. AGO2 RIP indicated that hsa_circ_0060927 had a sponge mechanism. RNA pull-down and dual luciferase reporter gene assay suggested that hsa_circ_0060927 interacted with miR-195-5p. Yes Overexpression of hsa_circ_0060927 enhanced the ability of cell proliferation and migration, and decreased cell apoptosis capacity. 35087744 hsa_circ_0001461 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cell lines and tumor tissues. Interaction(miR-145/TLR4/NF-κB axis) RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay In this study, we confirmed that circ_0001461 was highly expressed in OSCC cell lines and tumor tissues. Mechanistically, we found circ_0001461 regulates OSCC cell proliferation, migration and invasion through sponging miR-145. Furthermore, circ_0001461 promotes the resistance of TNF-α-induced apoptosis of OSCC cells by modulating miR-145/TLR4/NF-κB pathway. Yes Knocking down of circ_0001461 suppressed cell proliferation, migration and invasion in vitro, and repress xenograft tumor growth in vivo. 34119822 circLPAR3 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Interaction(miR-513b-5p/VEGFC and AKT1) CCK8//qRT-PCR//IHC circ_LPAR3 was upregulated in OSCC. Circ_LPAR3 promoted VEGFC and AKT1 activity by sponging miR-513b-5p in OSCC cells. Yes Its knockdown in cells could decrease cell survival and mobility and in mice model, could inhibit the tumor growth and angiogenesis. 34922206 circDHTKD1 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(miR-326/GAB1) RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//Transwell Assay Our expression analysis revealed that circDHTKD1 was upregulated in OSCC tissues and cells.Additionally, circDHTKD1 served as a microRNA-326 (miR-326) sponge and the function of circDHTKD1 was achieved by sponging miR-326 in OSCC cells. Also, miR-326 inhibited OSCC development via targeting GRB2-associated-binding protein 1 (GAB1). Yes circDHTKD1 knockdown was shown to impede OSCC cell growth and metastasis but motivate apoptosis. 34287578 circCDR1as CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(miR-876-5p/SLC7A11 ) qRT-PCR//Transwell Assay CircCDR1as level was aberrantly elevated in OSCC tissues and cells. CircCDR1as directly targeted miR-876-5p and miR-876-5p interacted with SLC7A11. MiR-876-5p overexpression reversed the effects of circCDR1as elevation on OSCC cell autophagy, cell cycle, growth, motility, and apoptosis. Yes Overexpression of circCDR1as promoted autophagy, cell cycle, proliferation, and metastasis and repressed apoptosis in OSCC cells. 34817912 hsa_circ_0011946 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cellsOSCC tissues and cells Interaction(miR-216a-5p/BCL2L2 axis) qRT-PCR//MTT//RNA Pull-Down//Western Blot Circ_0011946 and BCL2L2 levels were increased, while miR-216a-5p level was decreased in OSCC tissues and cells. Circ_0011946 knockdown impeded proliferation, migration, and invasion, but promoted apoptosis in OSCC cells. Circ_0011946 functioned as a sponge for miR-216a-5p, and BCL2L2 was targeted by miR-216a-5p. Besides, miR-216a-5p or BCL2L2 knockdown partly attenuated the inhibitory influences of circ_0011946 silence or miR-216a-5p overexpression on OSCC cell progression. Furthermore, circ_0011946 post-transcriptionally regulated BCL2L2 through sponging miR-216a-5p. Moreover, circ_0011946 knockdown constrained OSCC tumor growth in vivo. Yes Circ_0011946 knockdown impeded proliferation, migration, and invasion, but promoted apoptosis in OSCC cells.Furthermore, circ_0011946 post-transcriptionally regulated BCL2L2 through sponging miR-216a-5p. Moreover, circ_0011946 knockdown constrained OSCC tumor growth in vivo. 34620126 circHIPK3 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction(miR-381-3p-YAP1) qRT-PCR//Western Blot//Transwell Assay CircHIPK3 was elevated in OSCC tissues and cell lines, and decrease of circ-HIPK3 suppressed OSCC cell proliferation, invasion, migration and induced apoptosis in vitro as well as inhibited tumor growth in vivo. Rescue assay indicated circ-HIPK3 silence mediated OSCC progression inhibition by sponging miR-381-3p, which was a target of circ-HIPK3. Furthermore, miR-381-3p directly interacted with YAP1 and miR-381-3p inhibition could attenuate YAP1 deletion-induced suppression on cell malignant biological behavior in OSCC. Meanwhile, co-expression analysis showed circ-HIPK3 could regulate YAP1 expression by competing for miR-381-3p. Yes Rescue assay indicated circ-HIPK3 silence mediated OSCC progression inhibition by sponging miR-381-3p, which was a target of circ-HIPK3. 33737493 circFOXK2 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck oral squamous cell carcinoma Interaction(m6A-dependent IGF2BP3/GLUT1 axis) MeRIP-seq Here, m6A-circRNA epitranscriptomic microarray analysis revealed a high-expressed m6A-modified circFOXK2 (hsa_circ_0000816, from FOXK2 gene) in oral squamous cell carcinoma (OSCC). Methylated RNA immunoprecipitation sequencing (MeRIP-Seq) demonstrated that a remarkable m6A modified site was installed on glucose transporter 1 (GLUT1) mRNA. Mechanistically, circFOXK2 promoted the GLUT1 mRNA stability through cooperating with insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) in a m6A-dependent manner. Yes For the biofunctions of OSCC, results revealed that circFOXK2 promoted the malignant phenotypes of OSCC cells. 36127411 hsa_circ_0005050 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells Interaction(miR-23a-3p/miR-625-5p/STAT3 axis/ JAK/STAT3 signaling pathway) RNA Pull-Down//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay According to the collected data, circ_0005050 was significantly up-regulated in OSCC cells compared to normal cells.As for mechanism analyses, circ_0005050 knockdown led to the reduction of STAT3 expression and JAK/STAT3 signaling pathway activity. Moreover, circ_0005050 competitively bound to miR-23a-3p and miR-625-5p to up-regulate STAT3, thus prompting malignant behaviors of OSCC cells. Yes Circ_0005050 depletion hampered proliferative ability of OSCC cells while promoting cell apoptotic ability. 36155326 hsa_circ_0001971 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(miR-186-5p/FNDC3B axis) RIP//qRT-PCR//Bioinformatics Analysis Our study displayed that circRNA_0001971 and FNDC3B were elevated in OSCC, whereas miR-186-5p was declined in OSCC. In OSCC cells, circRNA_0001971 sponged miR-186-5p to enhance FNDC3B. Due to the interaction between circRNA_0001971, miR-186-5p, and FNDC3B, FNDC3B overexpression relieved the negative function of silencing circRNA_0001971 in OSCC cells. Yes Silencing circRNA_0001971 attenuated the malignancy of OSCC cells by suppressing proliferation, migration, and invasion. 35060189 hsa_circ_0049396 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(miR-663b/ENDOU axis) qRT-PCR//RIP The expression of circ_0049396 and ENDOU was downregulated in OSCC tissues and cells, whereas miR-663b was upregulated. MiR-663b mimic enhanced the migratory and proliferative abilities of OSCC cells, but suppressed apoptosis. Furthermore, circ_0049396 or ENDOU overexpression partially reversed the malignant behavior of miR-663b-overexpressing OSCC cells. Yes Circ_0049396 overexpression weakened OSCC cell proliferation and migration but enhanced their apoptosis. Circ_0049396 overexpression suppresses tumorigenesis in vivo. 36581129 hsa_circ_0004491 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction(miR-2278/GNAS) Western Blot//Flow Cytometry//qRT-PCR//RIP//Colony Formation Assay//EdU Staining//Transwell Assay Circ_0004491 was downregulated in OSCC tissues and cell lines. Circ_0004491 acted as a molecular sponge for miR-2278, and circ_0004491 overexpression-mediated effect was partly reversed by miR-2278 mimic in OSCC cells. MiR-2278 interacted with the 3'UTR of GNAS. Circ_0004491 contributed to GNAS level by sponging miR-2278 in OSCC cells. GNAS knockdown restored miR-2278 inhibitor-mediated effect in OSCC cells. Yes Circ_0004491 overexpression suppressed the proliferation, migration and invasion whereas facilitated the apoptosis of OSCC cells.Circ_0004491 overexpression repressed xenograft tumor growth in vivo. 36643221 hsa_circ_0006948 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines Interaction( N-cadherin) CCK8//qRT-PCR Circ_0006948 was upregulated in BC tissues and cell lines. The key protein in the EMT signaling E-cadherin was upregulated by knockdown of circ_0006948 in BC cells, while N-cadherin, Vimentin, β-catenin and MMP-9 were downregulated. The interaction between circ_0006948 and N-cadherin was identified, and they were co-responsible for the malignant development of BC. High level of circ_0006948 indicated advanced tumor stage, high rates of lymph node metastasis and distant metastasis, and poor prognosis in BC. Yes . Knockdown of circ_0006948 reduced proliferative and metastatic abilities in BC cells. 34565009 hsa_circ_100984 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Interaction(miR‐432‐3p/ c‐Jun/YBX‐1/β‐catenin feedback loop) qRT-PCR//RIP Here, we found that circ_100984 and YBX‐1 were high presented, while miR‐432‐3p was low presented in BC. Mechanistically, we revealed that circ_100984 served as a competing endogenous RNA that sponged miR‐432‐3p to indirectly regulate YBX‐1 and epithelial‐mesenchymal transition (EMT)‐related molecules. Moreover, we confirmed that YBX‐1 or c‐Jun acted as a transcription regulatory factor for β‐catenin or YBX‐1, respectively, in BC cells. Knockdown of YBX‐1 inhibited the expression of β‐catenin and c‐Jun, whereas downregulated c‐Jun inversely repressed the expression of YBX‐1 and β‐catenin. Yes Silencing of circ_100984 and YBX‐1 repressed BC tumor growth, migration, and invasion in vitro and in vivo. 33314480 circZFR CircRNA Homo sapiens Urinary Bladder Neoplasms BCa cell lines Interaction(miR-545 and miR-1270) qRT-PCR//Western Blot The expression of CircZFR was up-regulated both in BCa tissues and in BCa cell lines, and was positively correlated with patient survival rates.On the other hand, overexpression of target miRNA supported that circZFR directly interact with miR-545 and miR-1270. Moreover, we demonstrated that circZFR promotes the progression of BCa by upregulating WNT5A's expression via sponging miR-545 and miR-1270. The expression of CircZFR was up-regulated both in BCa tissues and in BCa cell lines, and was positively correlated with patient survival rates. Yes Blocking of circZFR's expression by RNA inhibitors suppressed the proliferation, migration and invasion of BCa cells both in vitro and in vivo. 33928018 hsa_circ_0001756 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines Regulation( IGF2BP2-mediated RAB5A expression) qRT-PCR//RNA Pull-Down//Co-IP Herein, we detected the expression of hsa_circ_0001756 in OC tissues and cell lines with RT-qPCR assay, which showed that hsa_circ_0001756 was upregulated in OC tissues and cell lines. Moreover, RNA pull-down assay verified the binding between hsa_circ_0001756 and IGF2 mRNA binding protein 2 (IGF2BP2), and rescue experiments indicated that IGF2BP2 overexpression reversed the effects of has_circ_0001756 knockdown on OC cell functions. Co-IP assay verified IGF2BP2 could interact with RAB GTPase 5A (RAB5A) protein. Yes We found that hsa_circ_0001756 knockdown inhibited OC cell proliferation, invasion and EMT. 35113003 hsa_circ_0063804 CircRNA Homo sapiens Ovarian Neoplasms OC patients and cells Interaction(miR-1276/CLU axis) CCK8//qRT-PCR//Western Blot Circ_0063804 expression was up-regulated in OC patients and indicated poor prognosis (P < 0.05). Circ_0063804 had a stable circle structure. CLU was directly inhibited by miR-1276 and up-regulated in OC patients. Circ_0063804 exacerbated malignant phenotype and resistance to cisplatin of OC cells in vitro by enhancing CLU expression via sponging miR-1276 (P < 0.01). Circ_0063804 silencing inhibited OC cells growth, resistance to cisplatin and Ki67 expression in vivo (P < 0.01). Circ_0063804 expression was up-regulated in OC patients and indicated poor prognosis (P < 0.05). Circ_0063804 had a stable circle structure. Yes Circ_0063804 enhanced proliferation, resistance to cisplatin and reduced apoptosis of OC cells (P < 0.01). miR-1276 was down-regulated in OC patients and sponged by circ_0063804. 35687899 circRNF144B CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-342-3p/FBXL11 ) In Vivo Experiment//qRT-PCR//FISH CircRNF144B was elevated in OC tissues with low autophagy levels, and associated with poor prognosis. Mechanistically, circRNF144B acts as a sponge for miR-342-3p and inhibits miR-342-3p-induced degradation of lysine demethylase 2 A (FBXL11) mRNA, leading to elevated FBXL11 protein levels. Elevated FBXL11 promoted the ubiquitination and degradation of Beclin-1, thus inhibiting autophagy. CircRNF144B was elevated in OC tissues with low autophagy levels, and associated with poor prognosis. Yes CircRNF144B promoted the malignant biological properties of OC cells, and inhibited the autophagy. 36209140 circFNDC3B CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Regulation[miR-1178-3p/G3BP2/SRC/FAK axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//FISH We found that circFNDC3B was dramatically downregulated in BC tissues and correlated with pathological T stage, grade, lymphatic invasion and patients' overall survival rate. Mechanistically, circFNDC3B could directly bind to miR-1178-3p, which targeted the 5'UTR of the oncogene G3BP2. Moreover, circFNDC3B acted as a miR-1178-3p sponge to suppress G3BP2, thereby inhibiting the downstream SRC/FAK signaling pathway. We found that circFNDC3B was dramatically downregulated in BC tissues and correlated with pathological T stage, grade, lymphatic invasion and patients' overall survival rate. Yes Functionally, overexpression of circFNDC3B significantly inhibited proliferation, migration and invasion both in vitro and in vivo. 30458784 circUBXN7 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Regulation[circUBXN7-miR-1247-3p-B4GALT3 regulatory network] Western Blot//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Here, we identified a novel circular RNA, termed circUBXN7, which was significantly downregulated in BC tissues compared with matched nontumor tissues.The circUBXN7-miR-1247-3p-B4GALT3 regulatory network may provide a new perspective for gene-based treatment strategies for BC. Importantly, we found that decreased circUBXN7 expression was associated with pathological stage, grade and poor prognosis of BC patients. Yes Functional experiments showed that circUBXN7 overexpression dramatically inhibited proliferation, migration and invasion in vitro and suppressed tumor growth in vivo. 30312173 circCEP128 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues interaction[ miR-145-5p,SOX11 ] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay In present study, circCEP128 and SOX11 were observed significantly up-regulated in bladder cancer tissues, while the expression of miR-145-5p was decreased in cancer samples compared to normal samples. CircCEP128 functions as a ceRNA for miR-145-5p, which could up regulates SOX11 and further promotes cell proliferation and inhibits cell apoptosis of bladder cancer. Yes Knockdown of circCEP128 induced the inhibition of cell proliferation and the increased bladder cancer cell apoptosis rate. 30134837 circSLC8A1 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cell lines Regulation[circSLC8A1/miR-130b, miR-494/PTEN axis ] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In the present study, we found that circSLC8A1 was down-regulated in bladder cancer tissues and cell lines, and circSLC8A1 expression was associated with the pathological stage and histological grade of bladder cancer. CircSLC8A1 acts as a tumor suppressor by a novel circSLC8A1/miR-130b, miR-494/PTEN axis, which may provide a potential biomarker and therapeutic target for the management of bladder cancer. Yes Over-expression of circSLC8A1 inhibited cell migration, invasion and proliferation both in vitro and in vivo. 31228937 hsa_circ_403658 CircRNA Homo sapiens Urinary Bladder Neoplasms Bladder cancer tissues and the matched adjacent tissues,cell lines(CCC-HB-2,SW780, 5637, T24, J82 and RT4) Interaction[LDHA] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//Western Blot has_circRNA_403658 expression was higher in bladder cancer tissues than in the matched adjacent tissues.In addition, has-circRNA-403658 was induced by HIF1α and silencing has-circRNA-403658 inhibited LDHA-mediated aerobic glycolysis, inhibiting bladder cancer cell growth. We demonstrated that has-circRNA-403658 was an important circRNA that upregulated in bladder cancer cells under hypoxia, and higher has-circRNA-403658 levels were associated with poorer survival outcome. Yes Silencing has-circRNA-403658 in bladder cancer cells inhibited cell growth and induced cell apoptosis. 31814891 circMTO1 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and the matched adjacent tissues,cell lines (UMUC3, SVHUC1, T24, J82,5637,CCC-HB-2) Interaction[ sponging miR-221] Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay We found that circMTO1 was significantly decreased in bladder cancer tissues compared with adjacent tissues.Compared with CCC-HB-1 cells, the expression of circMTO1 was significantly downregulated in five bladder cancer cell lines.In addition, we also revealed that circMTO1 was able to sponge miR-221 and overexpression of circMTO1 negatively regulated the E-cadherin/N-cadherin pathway to inhibit bladder cancer cells' EMT by competing for miR-221. We first demonstrated that circMTO1 was an important circRNA frequently downregulated in bladder cancer tissue, and lower circMTO1 levels were positively correlated with bladder cancer patients' metastasis and poorer survival. Yes Ectopic expression of circMTO1 in bladder cancer cells inhibited cell's epithelial-to-mesenchymal transition (EMT) and metastasis. 30551873 circFoxo3 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction[miR-191-5p] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot circ-Foxo3 was Expression[down-expression]regulated in bladder cancer in vivo and in vitro, and was Expression[Expression[up-expression]-expression]regulated in response to apoptotic stress. We further characterized the interaction between circ-Foxo3 and miR-191 and its functional impact on bladder cancer cells. Yes Overexpression of circ-Foxo3 promoted bladder cancer cell apoptosis in BBN mice and in human bladder cancer cell lines. 31802888 circPTPRA CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Interaction[miR-636,KLF9] qRT-PCR//Luciferase Report Assay//FISH By using qRT-PCR analysis, we verified that circPTPRA is Expression[down-expression]-regulated in clinical BC specimens compared with the matched non-tumor samples, while correlation analyses showed that low circPTPRA expression is associated with poor prognosis, advanced tumor stage and larger tumor size.Cell transfection experiments showed that miR-636 promotes the proliferation of BC cells by decreasing the expression of Krüppel Like Factor 9 (KLF9) Expression[Expression[up-expression]-expression]on binding to the 3'UTR of its mRNA.Further analysis confirmed that circPTPRA competitively sponges miR-636 to Expression[Expression[up-expression]-expression]regulate the KLF9 expression, leading to decreased proliferation of BC cells. By using qRT-PCR analysis, we verified that circPTPRA is Expression[down-expression]-regulated in clinical BC specimens compared with the matched non-tumor samples, while correlation analyses showed that low circPTPRA expression is associated with poor prognosis, advanced tumor stage and larger tumor size. Yes Based on these findings, we conducted functional assays and revealed that circPTPRA inhibits BC cell proliferation in vitro and tumor growth in vivo. 31821171 hsa_circ_0084606 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137613 exhibited a high degree of Expression[down-expression]regulation. Yes The Transwell assays revealed that hsa_circ_0137606 knockExpression[down-expression] significantly promoted BC cell migration (Fig. 5D) and invasion (Fig. 5E) compared with the NC groExpression[Expression[up-expression]-expression]. In summary, hsa_circ_0137606 knockExpression[down-expression] promoted the proliferation and metastasis of BC cells in vitro. 30892069 circVANGL1 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Interaction[miR-605-3p/VANGL1 pathway] CCK8//Luciferase Report Assay//Western Blot We found that circ-VANGL1 was highly expressed in BC tissues compared with adjacent normal tissues.Mechanistically, we identified circ-VANGL1 as a sponge of miR-605-3p which targeted VANGL1 in BC cells. Through repressing miR-605-3p availability, circ-VANGL1 contributes to VANGL1 expression, consequently leading to BC cell proliferation, migration, and invasion. Furthermore, we showed that circ-VANGL1 could serve as a prognostic marker for patients with BC. Yes Through functional experiments, we found that circ-VANGL1 knockExpression[down-expression] significantly sExpression[Expression[up-expression]-expression]pressed BC cell proliferation, cell cycle, migration, and invasion in vitro. Besides, circ-VANGL1 silence inhibited BC cell propagation in vivo. 30146736 hsa_circ_0058063 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Interaction[sponging miR-145-5p ] qRT-PCR//Wound Healing Assay//MTT//Western Blot Circ_0058063 was significantly overexpressed in BC tissues. Circ_0058063 repressed miR-145-5p, which inhibited the expression of CDK6. Downregulation of circ_0058063 or miR-145-5p transfection contributed to more cells arresting in G0/G1 stage. MiR-145-5p suppressed cell growth and migration ability in BC, whereas CDK6 exerted the opposite influence on these cellular events. In vivo experiment also indicated that tumor development in BALB/c nude mice was repressed remarkably when circ_0058063 was downregulated. Yes The downregulation of circ_0058063 impaired BC cell proliferation and migration ability but improved cell apoptosis ability. Circ_0058063 repressed miR-145-5p, which inhibited the expression of CDK6. Downregulation of circ_0058063 or miR-145-5p transfection contributed to more cells arresting in G0/G1 stage. 30362519 hsa_circ_0001361 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues , cell lines Regulation[miR-491-5p/MMP9 axis] qRT-PCR//Luciferase Report Assay//RNA-seq In this study, we focused on the upregulated circRNAs and identified a novel circular RNA, hsa_circ_0001361 (circ0001361), was expressed at high levels in BC tissues and cell lines based on RNA-Seq data and qRT-PCR analysis, and it was positively corelated with pathologic grade and muscle invasion. Mechanistically, RNA sequencing analysis indicated that MMP9 was upregulated in circ0001361-overexpressed BC cells, and MMP9 was verified to mediate circ0001361-induced cell migration and invasion. Furthermore, we demonstrated that circ0001361 could directly interact with miR-491-5p to upregulate MMP9 expression. Collectively, our findings indicate that circ0001361 plays oncogenic role in BC invasion and metastasis through targeting the miR-491-5p/MMP9 axis, and it might be a potential novel target for BC therapy. Moreover, Kaplan-Meier survival analysis implied that BC patients with high circ0001361 expression level had a poor overall survival. Yes Functionally, circ0001361 promoted BC cell invasion and metastasis both in vitro and in vivo, but had no effect on cell cycle and proliferation. 31705065 hsa_circ_0001429 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction[binding miR-205-5p ] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Expressions of circ0001429 and VEGFA were up-regulated, whereas miR-205-5p expression was down-regulated in bladder cancer tissues in comparison with paired adjacent normal bladder tissues. Circ0001429 sponged miR-205-5p that targeted VEGFA, thereby modulating the protein level of VEGFA. Meanwhile, miR-205-5p restrained the cell viability and mobility and promoted the apoptosis in bladder cancer. Circ0001429 could accelerate cell propagation, migration and invasiveness through increasing VEGFA expression via miR-205-5p. Yes Circ0001429 enhanced the propagation and metastasis abilities of T24 cells and 5637 cells in vitro, but reduced cell apoptosis.In vivo experiments revealed the inhibitor role of sh-circ0001429 in tumor growth and lung metastasis. 30909190 hsa_circ_0068871 CircRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cell lines Interaction[targeting miR-181a-5p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay Hsa_circ_0068871 is over-expressed in BCa tissues and cell lines, whereas miR-181a-5p expression is repressed. Mechanistically, hsa_circ_0068871 upregulated FGFR3 expression and activated STAT3 by targeting miR-181a-5p to promote BCa progression. Yes Depletion of has_circ_0068871 or upregulation of miR-181a-5p inhibited the proliferation and migration of BCa cells in vitro and in vivo. 30999937 circZFR CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues,cell lines Regulation[miR-377/ZEB2 signaling] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay First, we demonstrated that the expression of circZFR was higher in bladder cancer tissues and cells compared with adjacent non-tumor tissues and normal bladder epithelial cells.Mechanistically, we observed that circZFR could directly bind to miR-377 as sponge to promote ZEB2 expression in bladder cancer cells. In addition, rescue assays demonstrated that restoration of ZEB2 significantly impaired the suppressive effects of circZFR silencing on bladder cancer cells growth, migration and invasion. Taken together, our results illuminated that circZFR could be a prognostic biomarker in bladder cancer and exerted oncogenic roles through regulating miR-377/ZEB2 axis in bladder cancer, which indicated that circZFR could be a potential therapeutic target for bladder cancer patients treatment. Yes Functionally, knockdown of circZFR could significantly prohibit cell growth, migration and invasion, arrest cell cycle as well as promote apoptosis of bladder cancer cells in vitro study. 31746333 circCEP128 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder tissue,blood Regulation[MAPK signaling pathway] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//CCK8//Luciferase Report Assay Expression of miR-145-5p was decreased in cancer samples. Overexpression of miR-145-5p or knockdown of circCEP128 promoted MAKP signaling pathway and related proteins expression. In addition, knockdown of circCEP128 suppressed the growth of bladder cancer tumor tissues in vivo. Overexpression of circCEP128 promoted bladder cancer progression through modulating miR-145-5p and MYD88 via MAKP signaling pathway. Yes Knockdown of circCEP128 induced the inhibition of cell viability and mobility and cell cycle arrest. 30939216 circNR3C1 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues,cell lines Interaction[sponging miR-27a-3p] qRT-PCR " In this study, we discovered that a circular RNA derived from NR3C1 (circNR3C1) was downregulated in bladder cancer tissues and cell lines according to RNA-Seq data and qRT-PCR analysis.Mechanistically, we demonstrated that circNR3C1 possessed four targeting sites of miR-27a-3p and could effectively sponge miR-27a-3p to suppress the expression of cyclin D1. Furthermore, we revealed that miR-27a-3p functioned as an oncogene through interacting with 5'UTR of cyclin D1 to enhance its expression, which led to promote cell cycle progression and proliferation in bladder cancer cells. Conclusively, our findings further confirm the hypothesis that circRNAs function as ""microRNA sponges"", and our data suggest that circNR3C1 and miR-27a-3p would be potential therapeutic targets for bladder cancer treatment." Yes Functionally, we found that overexpression of circNR3C1 could significantly inhibit cell cycle progression and proliferation of bladder cancer cells in vitro, as well as suppress tumor growth in vivo. 31255724 hsa_circ_0061140 CircRNA Homo sapiens Ovarian Neoplasms OC samples and cells Interaction(miR-361-5p/RAB1A) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay The circ_0061140 level was upregulated in OC samples and cells. Yes Downregulation of circ_0061140 impeded proliferation, migration, invasion, EMT, and angiogenesis of OC cells. 35181843 circAHNAK CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cells Interaction(miR-28/EIF2B5/ JAK2/STAT3 signaling pathway) qRT-PCR//Wound Healing Assay//Western Blot We reported that circAHNAK was decreased in ovarian cancer tissues. Mechanistically, circAHNAK acted as a miR-28 sponge. CircAHNAK deficiency resulted in the amassing of miR-28, which was elevated in ovarian cancer and promoted cancer cell malignancy. MiR-28 in turn inhibited EIF2B5 expression. Silence of EIF2B5 abolished the anticancer effects of miR-28 inhibitor. CircAHNAK overexpression retarded tumor growth in vivo, along with the decreased miR-28 and increased EIF2B, as well as EMT inhibition. Yes Forced expression of circAHNAK promoted apoptosis and inhibited cell proliferation, migration, invasion, EMT and JAK2/STAT3 signaling pathway. 35710311 hsa_circ_0030586 CircRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cells Interaction(miR-665/NR4A3 axis) qRT-PCR//Bioinformatics Analysis The expression of circ_0030586 was significantly decreased in BCa tissues and cells, as suggested by RT-qPCR. Circ_0030586 served as a competing endogenous RNA (ceRNA) for hsa-miR-665 to upregulate the expression of nuclear receptor subfamily 4 group A member 3 (NR4A3) which is a downstream target gene of miR-665 in BCa. Yes Colony formation, 5-Ethynyl-2'-deoxyuridine and sphere formation assays revealed that overexpression of circ_0030586 suppressed BCa cell proliferation and stemness in vitro. According to xenograft experiment, circ_0030586 overexpression suppressed tumor growth in vivo. 34175686 circNFIX CircRNA Homo sapiens Ovarian Neoplasms OC tissues, HUVECs Interaction(miR-518a-3p/TRIM44 axis) qRT-PCR//RNA Pull-Down//Western Blot CircNFIX and TRIM44 expression were higher and miR-518a-3p was lower in OC tissues than in the adjacent tissues. OC-derived exosomal circNFIX positively regulated TRIM44 expression by targeting miR-518a-3p in HUVECs. OC-derived exosomal circNFIX promoted angiogenesis by regulating the Janus-activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) pathway via miR-518a-3p/TRIM44 axis in HUVECs. Upregulated circNFIX and TRIM44 were significantly correlated with the tumor size and International Federation of Gynecology and Obstetrics (FIGO) stage of OC patients. Yes HUVECs treated OC-derived exosomes had higher proliferation, migration, and angiogenesis capacities than the control group. While OC-derived exosomal circNFIX silencing restrained HUVECs' proliferation, migration, and angiogenesis, compared with the OC-derived exosomes group. 36448712 hsa_circ_0004712 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-331-3p/FZD4 pathway) Western Blot//Flow Cytometry//qRT-PCR//RIP//CCK8//IHC//Transwell Assay In our results, hsa_circ_0004712 was aberrantly overexpressed in OC tissues and cells.Hsa_circ_0004712 directly targeted miR-331-3p whose inhibitors reversed the effects of hsa_circ_0004712 downregulation. FZD4 was targeted by miR-331-3p, and hsa_circ_0004712 could positively regulated FZD4 expression by targeting miR-331-3p. Yes Downregulation of hsa_circ_0004712 impaired OC cell proliferation, colony formation, invasion and migration, and accelerated apoptosis. 34507595 hsa_circ_0026123 CircRNA Homo sapiens Ovarian Neoplasms OVA tissues and cell lines Interaction(miR‑124‑3p/EZH2 signaling pathway) qRT-PCR//Luciferase Report Assay//FISH The results confirmed that hsa_circ_0026123 expression was upregulated in OVA tissues and cell lines, while hsa_circ_0026123 silencing suppressed cell proliferation and migration. The results revealed that hsa_circ_0026123 silencing suppressed ovarian cancer cell progression via the miR‑124‑3p/EZH2 signaling pathway. Yes it also suppressed the expression of cancer stem cell (CSC) differentiation?related markers in either in vivo or in vitro experiments. 33416105 circCRIM1 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Interaction( miR-383-5p/ZEB2 axis) qRT-PCR//Wound Healing Assay//MTT//Western Blot CircCRIM1 and CRIM1 had higher expression in ovarian cancer than in normal ovarian tissues, and both of them promoted ovarian cancer progression in vitro. CircCRIM1 and CRIM1 had a positive correlation relationship in the same cohort of ovarian cancer tissues. Bioinformatics predicted and dual luciferase assay confirmed circCRIM1 and CRIM1 bond with miR-145-5p, and circCRIM1 bond with miR-383-5p additionally. CircCRIM1 positively affected the expression of CRIM1. After circCRIM1 was over-expressed, miR-145-5p mimics transfection reversed the expression of CRIM1. Western blot discovered circCRIM1 positively affected the expression of zinc finger E-box binding homeobox 2 (ZEB2). Yes CircCRIM1 and CRIM1 had higher expression in ovarian cancer than in normal ovarian tissues, and both of them promoted ovarian cancer progression in vitro. In vivo circCRIM1 promoted the growth of tumors. 34847936 circATRNL1 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cells Interaction(miR-378/Smad4 ) qRT-PCR//Luciferase Report Assay//RIP circATRNL1 was decreased while miR-378 was increased in human ovarian cancer tissues and cells.circATRNL1 bound to miR-378 while miR-378 directly targeted Smad4. Yes Overexpression of circATRNL1 or knockdown of miR-378 suppressed angiogenesis and ovarian cancer cell proliferation, invasion, and migration via decreasing proliferation- and migration-related proteins via miR-378 or Smad4, respectively. Overexpression of circATRNL1 restrained ovarian cancer growth and abdominal metastasis in vivo. 33372356 hsa_circ_0072995 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-122-5p/SLC1A5 Axis) Flow Cytometry//qRT-PCR//RIP//Western Blot Circ_0072995 was upregulated in OC tissues and cells in a stable structure. Mechanistically, miR-122-5p was a direct target of circ_0072995, and its knockdown reversed the effects of circ_0072995 silence on inhibition of OC cell progression. Meanwhile, SLC1A5 was a downstream target gene of miR-122-5p, and miR-122-5p overexpression inhibited the progression of OC cells by targeting SLC1A5. Moreover, circ_0072995 positively regulated SLC1A5 expression via sponging miR-122-5p. Yes Functional experiments indicated that circ_0072995 knockdown suppressed cell proliferation, migration, invasion and accelerated cell apoptosis of OC cells. 34132956 hsa_circ_0000745 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(microRNA-3187-3p/ERBB4/PI3K/AKT axis) Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Circ_0000745 and ERBB4 were abundantly expressed while miR-3187-3p was poorly expressed in OC tissues and cells. Circ_0000745 sequestered miR-3187-3p and blocked its repressive effect on ERBB4.By contrast, artificial induction of circ_0000745 upregulation, miR-3187-3p upregulation and ERBB4 downregulation led to inverse trends in ES-2 cells. ERBB4 promoted the phosphorylation of the PI3K/AKT signaling pathway. Yes Downregulation of circ_0000745 reduced proliferation, aggressiveness, epithelial-mesenchymal transition, and stemness of SK-OV-3 cells, but this reduction was blocked upon miR-3187-3p inhibition or ERBB4 upregulation. 34774079 hsa_circ_0002711 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cell line Interaction(miR-1244/ROCK1 axis) qRT-PCR//MTT//RIP Circ_0002711 was upregulated in OC tissues and cell lines.Circ_0002711 contained binding sites with miR1244. Moreover, loss of miR-1244 undermined circ_0002711 downregulation-mediated function. ROCK1 contained binding sites with miR-1244. Yes Circ_0002711 downregulation inhibited cell viability, colony formation ability and aerobic glycolysis. 33737494 hsa_circ_0025033 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-184/LSM4) qRT-PCR//IHC//Transwell Assay " The expression of circ_0025033 and LSM4 was promoted in OC tissues and cells. Circ_0025033 knockdown or LSM4 knockdown blocked the ability of colony formation, migration/invasion and glycolysis metabolism in OC cells. In mechanism, circ_0025033 functioned as a ""competing endogenous RNA (ceRNA)"" to modulate LSM4 expression by targeting miR-184. LSM4 overexpression recovered the inhibitory effects on colony formation, migration/invasion and glycolysis metabolism caused by circ_0025033 knockdown. Moreover, circ_0025033 knockdown also inhibited tumor growth in vivo by regulating LSM4 and targeting miR-184." Yes Circ_0025033 knockdown or LSM4 knockdown blocked the ability of colony formation, migration/invasion and glycolysis metabolism in OC cells. 33285422 circATRNL1 CircRNA Homo sapiens Ovarian Neoplasms 20 ovarian cancer tissues Expression(lower expressed) CCK8//qRT-PCR CircATRNL1 and circZNF608 were downregulated in 20 ovarian cancer tissues compared to normal tissues. CircATRNL1 and circZNF608 are mainly located in the cytoplasm of ovarian cancer cells, and circATRNL1 is a highly conserved circRNA.However, a luciferase reporter assay showed that only miR-152-5p was sequestered by circZNF608.Bioinformatics analysis and experiments indicated that circATRNL1 contains an internal ribosome entry site and an open reading frame encoding a 131 aa protein. Yes The overexpression of circATRNL1 and circZNF608 inhibits the proliferation and invasion of ovarian cancer cells. 35281849 circZNF608 CircRNA Homo sapiens Ovarian Neoplasms 20 ovarian cancer tissues Interaction(miR-152-5p) CCK8//qRT-PCR CircATRNL1 and circZNF608 were downregulated in 20 ovarian cancer tissues compared to normal tissues. CircATRNL1 and circZNF608 are mainly located in the cytoplasm of ovarian cancer cells, and circATRNL1 is a highly conserved circRNA.However, a luciferase reporter assay showed that only miR-152-5p was sequestered by circZNF608.Bioinformatics analysis and experiments indicated that circATRNL1 contains an internal ribosome entry site and an open reading frame encoding a 131 aa protein. Yes The overexpression of circATRNL1 and circZNF608 inhibits the proliferation and invasion of ovarian cancer cells. 35281849 hsa_circ_0015756 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-145-5p/PSAT1 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay Circ_0015756 was highly expressed in OC tissues and cells. In a mechanical study, circ_0015756 directly bound to miR-145-5p, and inhibition of miR-145-5p reversed the effects of circ_0015756 knockdown on OC cells. Moreover, miR-145-5p directly targeted PSAT1, and miR-145-5p weakened OC cell growth, migration and invasion via targeting PSAT1. Yes Knockdown of circ_0015756 suppressed cancer cell growth, migration and invasion in vitro, as well as impeded tumor growth in vivo. 36327671 hsa_circ_0078607 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-32-5p/SIK1 network) Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0078607 and SIK1 were downregulated in OC tissues and cells.Furthermore, SIK1 was a target of miR-32-5p, and circ_0078607 could regulate SIK1 by sponging miR-32-5p. The inhibitory effect of circ_0078607 on OC progression also could be reversed by SIK1 silencing. In vivo experiments showed that circ_0078607 reduced OC tumorigenesis by regulating the miR-32-5p/SIK1 axis. Yes Overexpressed circ_0078607 and SIK1 could inhibit OC cell proliferation, migration, invasion, and promote apoptosis. MiR-32-5p could be sponged by circ_0078607, and its overexpression could reverse the suppressive effect of circ_0078607 on OC progression. 34983607 hsa_circ_0000144 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer cells and tissues Interaction(miR-610/ELK3 ) qRT-PCR//Wound Healing Assay//RNA Pull-Down//Colony Formation Assay Circ_0000144 was significantly upregulated in ovarian cancer cells and tissues. This study further demonstrated that circ_0000144 downregulated ELK3 levels by sponging miR-610 in ovarian cancer cells. Yes Circ_0000144 overexpression significantly promoted ovarian cancer cell proliferation, migration, and invasion. Moreover, circ_0000144 significantly promotes ovarian cancer tumorigenesis in vivo. 36243865 hsa_circ_0000497 CircRNA Homo sapiens Ovarian Neoplasms 22 samples Expression(highly expressed) qRT-PCR//RNA-seq//Western Blot Among them, hsa_circ_0000497 and hsa_circ_0000918 were significantly up-regulated in ASC. Yes Functional analysis showed that both hsa_circ_0000497 and hsa_circ_0000918 promoted metastasis of EOC via epithelial-mesenchymal transition (EMT) in vitro. 35538537 hsa_circ_0000918 CircRNA Homo sapiens Ovarian Neoplasms 22 samples Expression(highly expressed) qRT-PCR//RNA-seq//Western Blot Among them, hsa_circ_0000497 and hsa_circ_0000918 were significantly up-regulated in ASC. Yes Functional analysis showed that both hsa_circ_0000497 and hsa_circ_0000918 promoted metastasis of EOC via epithelial-mesenchymal transition (EMT) in vitro. 35538537 hsa_circ_0067934 CircRNA Homo sapiens Ovarian Neoplasms OC samples and cells Interaction(microRNA-545-3p/PPA1 axis ) RIP//qRT-PCR//Tunel Circ_0067934 was overexpressed in OC samples and associated with advanced tumor staging and lymph node metastasis. Circ_0067934 served as a sponge for miR-545-3p and diminished its suppressive effect on PPA1 translation. Artificial upregulation of PPA1 enhanced proliferation, invasion and DDP resistance of A2780/DDP cells, and it reduced phosphorylation of the pro-apoptotic JNK signaling. Circ_0067934 was overexpressed in OC samples and associated with advanced tumor staging and lymph node metastasis. Yes Downregulation of circ_0067934 reduced DDP resistance of the DDP-resistant A2780/DDP cell line and reduced cell proliferation and invasion, but the malignant behaviors of OC cells were restored after further miR-545-3p downregulation. 35179434 hsa_circ_0000119 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer cells and tissues Interaction(miR-142-5p/CDH13 ) qRT-PCR//MTT In this present study, our data shows that hsa_circ_0000119 and DNA methyltransferase 1 (DNMT1) was increased, while miR-142-5p was decreased in ovarian cancer. Moreover, the data proves that hsa_circ_0000119 negatively regulated miR-142-5p and cadherin 13 (CDH13) expression, but positively regulated DNMT1 expression. miR-142-5p could interact with hsa_circ_0000119 and DNMT1 3'-UTR. Silencing of DNMT1 could reverse the inhibition of hsa_circ_0000119 to miR-142-5p and CDH13 expression. Importantly, higher level of CDH13 promoter methylation existed in the ovarian tumors than that in matched normal tissues. DNA methyltransferase inhibitor could increase the expression of CDH13 in ovarian cancer cells. Yes Overexpression of hsa_circ_0000119 promoted tumor growth, while silencing of hsa_circ_0000119 resulted in an opposite effects. Decreasing of hsa_circ_0000119 also notably inhibited the proliferation, migration, and invasion of the ovarian cancer cells. 36482494 hsa_circ_0000471 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines Interaction(mir-135b-5p/dusp5 axis) CCK8//qRT-PCR//Colony Formation Assay//Western Blot Circ_0000471 expression was down-regulated in OC tissues and cell lines. Circ_0000471 served as a molecular sponge for microRNA-135b-5p (miR-135b-5p), and circ_0000471 overexpression-mediated anti-tumor influences in OC cells were largely reversed by the overexpression of miR-135b-5p. Dual specificity phosphatase 5 (DUSP5) was a target of miR-135b-5p, and miR-135b-5p silencing-induced anti-tumor effects were largely counteracted by the interference of DUSP5. Circ_0000471 increased DUSP5 expression by sponging miR-135b-5p in OC cells. Yes Circ_0000471 overexpression blocked the proliferation, migration, and invasion and triggered the apoptosis of OC cells. Circ_0000471 overexpression restrained the growth of xenograft tumors in vivo. 36369900 hsa_circ_0025033 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cells Interaction(hsa_miR-370-3p/SLC1A5 axis) qRT-PCR//Transwell Assay circ_0025033 was upregulated in ovarian cancer; its knockdown induced proliferation, invasion, angiogenesis, glutamine metabolism, and apoptosis in vitro, and blocked tumor growth in vivo. circ_0025033 regulated ovarian cancer cellular behaviors via sponging hsa_miR-370-3p. In parallel, SLC1A5 might abolish the anti-ovarian cancer role of hsa_miR-370-3p. Furthermore, circ_0025033 affected SLC1A5 via regulating hsa_miR-370-3p. Yes circ_0025033 was upregulated in ovarian cancer; its knockdown induced proliferation, invasion, angiogenesis, glutamine metabolism, and apoptosis in vitro, and blocked tumor growth in vivo. 36273140 circVANGL1 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines Regulation[miR-1184/IGFBP2 axis] CCK8//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay The results showed that circVANGL1 was upregulated in both BC tissues and cell lines. Mechanistically, we demonstrated that circVANGL1 upregulated the expression of miR-1184 target gene insulin-like growth factor-binding protein 2 (IGFBP2) by sponging miR-1184, which promoted the aggressive biological behaviors of BC. Taken together, our results indicate that circVANGL1 acts as a tumor promoter through the novel circVANGL1/miR-1184/IGFBP2 axis. Hopefully, our study will provide new ideas for the clinical treatment of BC. Yes Silencing the expression of circVANGL1 suppressed cell invasion, migration, and proliferation during in vitro experiments. 31758655 circSMARCA5 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissue, cell lines Expression[highly expressed] CCK8//qRT-PCR//Western Blot Circ-SMARCA5 was overexpressed in tumor tissue compared to paired adjacent tissue and it was also overexpressed in TCCSUP, 5637, J82 and UM-UC-3 cells compared to normal human urothelial cell line SV-HUC-1. Yes In UM-UC-3 cells, cell proliferation ability, migration rate and invasion cell count were increased in Circ-SMARCA5(+) group compared to Control(+) group, while reduced in Circ-SMARCA5(-) group compared to Control(-) group. 35116915 circCDYL CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cell lines Interaction[down-regulating the expression of C-MYC] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Transwell Assay It was found that circCDYL was low expressed in bladder cancer tissues and cell lines.Importantly, over-expression of circCDYL down-regulated the protein level of C-MYC in both EJ and T24T cells, while the mRNA level of C-MYC was not significantly reduced. Furthermore, over-expression of C-MYC could partly reverse the G0/G1 phase cell cycle arrest induced by circCDYL in bladder cancer cells. Our findings suggest that circCDYL functions as a tumor suppressor in bladder cancer by down-regulating the expression of C-MYC, and this circular RNA might be used as a new target for bladder cancer therapy. Yes Functionally, over-expression of circCDYL inhibited cell growth and migration. 30968727 circACVR2A CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues,cell lines Regulation[miR-626/EYA4 axis] RNA Pull-Down//qRT-PCR//FISH//Luciferase Report Assay//RNA-seq The expression of circACVR2A was lower in bladder cancer tissues and cell lines.Our in vivo and in vitro data indicated that circACVR2A suppressed the proliferation, migration and invasion of bladder cancer cells. The down-regulation of circACVR2A was positively correlated with aggressive clinicopathological characteristics, and circACVR2A served as an independent risk factor for overall survival in bladder cancer patients after cystectomy. Yes Our in vivo and in vitro data indicated that circACVR2A suppressed the proliferation, migration and invasion of bladder cancer cells. 31101108 circCASC15 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cells regulation[CREB1] qRT-PCR The data from the microarray showed that hsa_circ_0075828 (named circCASC15) was most highly expressed in 5637 and T24 cells. circCASC15 was highly expressed in BC tissues and cells.Mechanistically, circCASC15 could act as miR-1224-5p sponge to activate the expression of CREB1 to promote cell proliferation in BC. Yes Overexpression of circCASC15 was closely associated with BC tumor stage and promoted cell proliferation significantly in vitro and in vivo. 31072448 circGLIS3 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cells Interaction(miR-1273f) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Cell Apoptosis Assay//EdU Staining//Transwell Assay In this study, we screened out a circRNA-circGLIS3 with a significant upregulation trend in both bladder cancer tissues and cells. Bioinformatics prediction results showed that circGLIS3 may be involved in multiple tumor-related pathways. Mechanically, circGLIS3 upregulates the expression of SKP1 by adsorbing miR-1273f and then promotes cyclin D1 expression, ultimately promoting the proliferation of bladder cancer cells. Yes Function gain and loss experiments verified circGLIS3 can affect the proliferation, migration, and invasion of bladder cancer cells in vitro. Moreover, silencing circGLIS3 inhibited bladder cancer cell growth in vivo. 33656636 hsa_circ_0000629 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cells Interaction(MicroRNA-1290/CDC73) CCK8//qRT-PCR//Flow Cytometry//EdU Staining Circ_0000629 and CDC73 were reduced, and miR-1290 was significantly overexpressed in BC tissues and cells. Yes Moreover, circ_0000629 significantly inhibited the development and metastasis of BC cells, but further overexpression of miR-1290 or knockdown of CDC73 attenuated the inhibitory effect of circ_0000629 on BC cells. 33790645 hsa_circ_0007813 CircRNA Homo sapiens Urinary Bladder Neoplasms clinical tissue samples and cell lines Interaction(miR-361-3p) CCK8//qRT-PCR//Western Blot//Transwell Assay Based on these findings from clinical tissue samples and cell lines, we assumed that hsa_circ_0007813 functioned a vital role in bladder cancer progression. Yes Next, functional experiments revealed that knockdown of hsa_circ_0007813 inhibited proliferation, migration, and invasiveness of bladder cancer cells both in vitro and in vivo. Through extensive bioinformatic prediction and RNA pull-down assays, we identified hsa-miR-361-3p as a competing endogenous RNA of hsa_circ_0007813. 34365465 circPPP1CB CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Interaction(microRNA 409-5p) RNA Pull-Down//Western Blot//Wound Healing Assay//Tube Formation Assay//Migration Assay//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//IF CircPPP1CB is downregulated in BC and is negatively correlated with clinical stages and histological grades. CircPPP1CB is downregulated in BC and is negatively correlated with clinical stages and histological grades. Yes Functionally, circPPP1CB modulated cell growth, metastasis, and epithelial-to-mesenchymal transition (EMT) process in vitro and in vivo. Mechanically, we performed various experiments to verify the circPPP1CB/miR-1307-3p/SMG1 regulatory axis. 34595165 circEHBP1 CircRNA Homo sapiens Urinary Bladder Neoplasms 186 pairs of tumor tissues and NATs from patients with BCa Interaction(miR-130a-3p/TGFβR1/VEGF-D signaling) CCK8//qRT-PCR Novel circRNA circEHBP1 was markedly upregulated in bladder cancer and correlated positively with lymphatic metastasis and poor prognosis of patients with bladder cancer. circEHBP1 upregulated transforming growth factor beta receptor 1 (TGFBR1) expression through physically binding to miR-130a-3p and antagonizing the suppression effect of miR-130a-3p on the 3' UTR region of TGFBR1. Novel circRNA circEHBP1 was markedly upregulated in bladder cancer and correlated positively with lymphatic metastasis and poor prognosis of patients with bladder cancer. Yes  Importantly, administration of VEGF-D neutralizing antibodies remarkably blocked circEHBP1-induced lymphangiogenesis and lymphatic metastasis in vivo.  33545359 hsa_circ_100284 CircRNA Homo sapiens Urinary Bladder Neoplasms Bladder cancer tissues and tissues beyond 1 cm adjacent to the cancer tissues Interaction(microRNA-217) qRT-PCR//Western Blot With prolonged contact time with arsenite, the expression level of circRNA-100284 in cells increased continuously (P < 0.05). Flow cytometry and CCK-8 showed that circRNA-100284 accelerated cell cycle transition and cell proliferation through miR-217. Yes Flow cytometry and CCK-8 showed that circRNA-100284 accelerated cell cycle transition and cell proliferation through miR-217. 33386469 circBIRC6 CircRNA Homo sapiens Urinary Bladder Neoplasms BC cell lines Interaction(miR‑495‑3p/XBP1 signaling axis) qRT-PCR//Wound Healing Assay//Transwell Assay The results demonstrated that circ‑BIRC6 expression was upregulated in BC cell lines. It was also identified that circ‑BIRC6 sponged miR‑495‑3p to regulate XBP1 expression. Yes Moreover, circ‑BIRC6 knockdown notably attenuated the proliferation, invasion, migration and EMT of BC cells, which was blocked by the miR‑495‑3p inhibitor. In addition, results from the xenograft experiments indicated that the knockdown of circ‑BIRC6 and miR‑495‑3p expression significantly inhibited tumor growth. 34542161 circMBOAT2 CircRNA Homo sapiens Urinary Bladder Neoplasms Bca tissues Interaction(miR-433-3p) qRT-PCR//RNA Pull-Down//Transwell Assay In this research, we identified that circMBOAT2 expression was increased in Bca tissues and positively corelated with unfavorable prognosis. Mechanically, circMBOAT2 was predominantly spread in cytoplasm and it sponged miR-433-3p to strengthen CREB1 expression. In this research, we identified that circMBOAT2 expression was increased in Bca tissues and positively corelated with unfavorable prognosis.  Yes In vitro assay demonstrated that suppression of circMBOAT2 impaired the proliferation and migration of Bca cells. 34563754 circST6GALNAC6 CircRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cells Interaction(miR-200a-3p /STMN1/EMT axis) qRT-PCR//ChIP circST6GALNAC6(hsa_circ_0088708) was downregulated in BCa tissues and cells. Mechanistically, we showed that the SP1 transcription factor, which binds to the circST6GALNAC6 mRNA transcript, activates circST6GALNAC6 transcription. Next, we verified that circST6GALNAC6 serves as a sponge that directly binds miR-200a-3p to regulate stathmin (STMN1) expression. Furthermore, we found that STMN1 is involved in circST6GALNAC6/miR-200a-3p axis-regulated BCa EMT and metastasis. Yes Overexpression of circST6GALNAC6 effectively inhibited the cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in vitro and suppressed BCa metastasis in vivo. 33568625 circRHOT1 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tumor tissues and cell lines Interaction(miR-3666/SMAD5) qRT-PCR//ChIP Our findings suggest that circRHOT1 was highly expressed in BC tumor tissues and cell lines. Subsequently, we conducted bioinformatics analysis followed by RNA pull-down, ChIP, and luciferase reporter assays, from which we found that circRHOT1 expression in BC cells could be regulated by ZNF652, and circRHOT1 could promote SMAD5 expression to regulate BC cell cellular progression by sponging miR-3666. Yes The results from CCK-8, EDU, Transwell migration, and NK cell-mediated cytotoxicity detection assays suggested that circRHOT1 knockdown could markedly suppress BC cell proliferation and migration level and could aggravate the sensitivity of BC cells to NK cells. 34926705 circUBE2K CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Interaction(miR-516b-5p/ARHGAP5 axis) qRT-PCR//Luciferase Report Assay//Western Blot High circUBE2K predicted unfavorable prognoses in BCs, as well as correlated with clinical features. Further studies showed that circUBE2K promoted BC progression via sponging miR-516b-5p and enhancing ARHGAP5 expression through regulating RhoA activity. Dual-luciferase reporter, FISH and RNA pulldown assays were employed to verify the relationships among circUBE2K/miR-516b-5p/ARHGAP5/RhoA axis. Yes CCK8, transwell, EdU and wound healing assays demonstrated down-regulating circUBE2K decreased BC cell phenotype as proliferation, invasion, and migration, respectively. 34285193 hsa_circ_0014130 CircRNA Homo sapiens Urinary Bladder Neoplasms cells and tissues of bladder cancer Interaction(miR-132-3p/KCNJ12 ) qRT-PCR//Western Blot The expressions of hsa_circ_0014130 were markedly ameliorated in bladder cancer samples and linked with aggressive characteristics and unfavorable survival. The expression of hsa_circ_0014130 was tied to miR-132-3p in a negative manner with the cells and tissues of bladder cancer. The underlined data revealed that hsa_circ_0014130 exerted its biological roles by regulating miR-132-3p/KCNJ12 expression. The expressions of hsa_circ_0014130 were markedly ameliorated in bladder cancer samples and linked with aggressive characteristics and unfavorable survival. Yes Ectopic expression of hsa_circ_0014130 clearly enhanced the differentiation, proliferative, migratory, invasive potential of the cell in bladder cancer, and the development of tumor xenograft in vivo, while malignant biological behaviors were inhibited by hsa_circ_0014130 knockdown. 34755307 hsa_circ_0001495 CircRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cells Interaction(miR-527/Robo1 ) qRT-PCR//Transwell Assay It was found that circ_0001495 was highly expressed in BCa tissues and cells, and was further correlated with poor prognosis in BCa patients. In addition, circ_0001495 inhibited the activity of miR-527 by acting as a sponge to sponge miR-527, which further elevated the Robo1 expression. It was found that circ_0001495 was highly expressed in BCa tissues and cells, and was further correlated with poor prognosis in BCa patients. Yes Lastly, circ_0001495 was found to promote the proliferation, migration and invasion of BCa cells in vitro through the miR-527/Robo1 axis and promote the growth and metastasis of BCa tumors in vivo. 34021307 circNT5E CircRNA Homo sapiens Urinary Bladder Neoplasms Bca tissues Interaction(miR-502-5p/HOXC8) qRT-PCR//RNA Pull-Down In this study, we observed that circNT5E expression was augmented in Bca tissues compared with that in adjacent normal tissues, and its expression level was positively associated with larger tumor size and lower survival rate. circNT5E was mainly distributed in the cytoplasm and it captured miR-502-5p to increase HOXC8 mRNA and protein expression. Moreover, decreased miR-502-5p obviously reversed the circNT5E silencing-mediated inhibition of Bca cell growth and migration. In this study, we observed that circNT5E expression was augmented in Bca tissues compared with that in adjacent normal tissues, and its expression level was positively associated with larger tumor size and lower survival rate. Yes Further experiments showed that suppression of circNT5E restrained the growth and metastasis of Bca cells in vitro. 33758619 hsa_circ_0000326 CircRNA Homo sapiens Urinary Bladder Neoplasms BC cell lines and tissues Interaction(miR-338-3p/miR-338-3p/ETS1/PI3K/AKT pathway) qRT-PCR//Wound Healing Assay Here, we found that circ_0000326 expression was significantly elevated in BC cell lines and tissues, and circ_0000326 could promote BC cell growth and migration, and inhibit apoptosis. Dual-luciferase reporter gene assay confirmed that circ_0000326 and ETS1 could bind directly to miR-338-3p. Furthermore, circ_0000326 sponged miR-338-3p and up-regulated ETS1 expression. ETS1 was associated with the activation of PI3K/AKT pathway. Moreover, circ_0000326 could activate PI3K/AKT pathway by miR-338-3p/ETS1 axis. Yes Here, we found that circ_0000326 expression was significantly elevated in BC cell lines and tissues, and circ_0000326 could promote BC cell growth and migration, and inhibit apoptosis. 34889689 circPTPRA CircRNA Homo sapiens Urinary Bladder Neoplasms BC cells Interaction(IGF2BP1 ) qRT-PCR//RIP We demonstrated that IGF2BP1 was predominantly binded with circPTPRA in the cytoplasm in BC cells. Importantly, circPTPRA downregulated IGF2BP1-regulation of MYC and FSCN1 expression via interacting with IGF2BP1. Moreover, the recognition of m6A-modified RNAs mediated by IGF2BP1 was partly disturbed by circPTPRA through its interaction with KH domains of IGF2BP1. Yes Ectopic expression of circPTPRA abolished the promotion of cell proliferation, migration and invasion of BC cells induced by IGF2BP1. 33853613 circNUDT21 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines Interaction(miR-16-1-3p/MDM2/p53 axis) CCK8//qRT-PCR The circNUDT21 level was overexpressed in BC tissues and cell lines as compared to normal controls.Mechanistical analysis showed that circNUDT21 acted as a miR-16-1-3p sponge and that MDM2 was a potential downstream target of miR-16-1-3p. We further verified that overexpression of circNUDT21 was associated with elevated MDM2 and reduced p53 expression. CircNUDT21 promoted BC progression by acting as a sponge of miR-16-1-3p to activate the miR-16-1-3p/MDM2/p53 axis. Yes Overexpression and silencing of circNUDT21 promoted and inhibited, respectively, the proliferative and invasive abilities of BC cells. 34703648 hsa_circ_0041103 CircRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cell lines Interaction(miR-107/FOXK1 axis) CCK8//qRT-PCR Circ0041103 was abnormally upregulated in BCa tissues and cell lines. MiR-107 was the binding target of circ0041103, and FOXK1 was the downstream gene of miR-107. Overexpression of circ0041103 could reverse the inhibited proliferative and metastatic capacities of T24 and UM-UC-3 cells overexpressing miR-107. Its level was higher in BCa tissues with a larger tumor size, or worse tumor staging, or BCa cases with lymphatic metastasis. Yes Knockdown of circ0041103 inhibited proliferative and metastatic capacities of T24 and UM-UC-3 cells. 33629298 hsa_circ_0091017 CircRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cell lines interaction[microRNA-589-5p] CCK8//qRT-PCR//EdU Staining//Transwell Assay QRT-PCR results revealed that the expression level of hsa_circ_0091017 was remarkably down-regulated in BCa tissues and cell lines, while the expression level of microRNA-589-5p was remarkably increased in BCa tissues and cells. The circular RNA hsa_circ_0091017 can inhibit the proliferation, migration and invasiveness of BCa cells by regulating the expression of microRNA-589-5p. Yes Overexpression of the circular RNA hsa_circ_0091017 in BCa cells can inhibit the proliferation, migration, and invasiveness of BCa cells. 31957821 circFAM114A2 CircRNA Homo sapiens Urinary Bladder Neoplasms UCB tissue specimens and cell lines regulation[circFAM114A2/miR-762/-NP63 axis] qRT-PCR//FISH In this study, we found circFAM114A2 was significantly downregulated both in UCB tissue specimens and cell lines, and the expression level was highly correlated with pathological TNM stage and grade.Taken together, our results demonstrated that circFAM114A2 might serve as a competing endogenous RNA (ceRNA) of miR-762 in regulating the expression of ∆NP63, thus suppressed UCB progression through circFAM114A2/miR-762/∆NP63 axis. In this study, we found circFAM114A2 was significantly downregulated both in UCB tissue specimens and cell lines, and the expression level was highly correlated with pathological TNM stage and grade. Yes Functionally, overexpression of circFAM114A2 dramatically inhibited the migration, invasion and proliferation of UCB cells in vitro, and suppressed tumor growth in vivo. 31969560 circRIP2 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues regulation[miR-1305/Tgf-β2/smad3 pathway] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay circRIP2 was identified as a conserved and dramatically repressed circular RNA in bladder cancer.Taken together, our study provides the first evidence that circRIP2 expresses differentially in bladder cancer and negatively along with the cancer progression; effective circRIP2 activity accelerates bladder cancer progression via inducing EMT by activating miR-1305/Tgf-β2/smad3 pathway. Yes In vitro and in vivo studies suggest that circRIP2 enables to promote bladder cancer progression via inducing EMT. 32019579 circSEMA5A CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines regulation[upregulating ENO1 and SEMA5A expression] RNA Pull-Down//Western Blot//EdU Staining//qRT-PCR//FISH//RIP//migration assay//Luciferase Report Assay//Invasion Assay In this study, we found that circSEMA5A was upregulated in BC tissues and cell lines.To sum up, circSEMA5A is upregulated in BC and facilitates BC progression by mediating miR-330-5p/ENO1 signaling and upregulating SEMA5A expression. Yes In vitro data indicated that circSEMA5A promoted proliferation, suppressed apoptosis, facilitated migration, accelerated invasion, enhanced angiogenesis and promotes glycolysis of BC. 33176280 hsa_circ_0137439 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[highly expressed] qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay//Microarray//Cell Cycle Assay//Transwell Assay We found that hsa_circ_0137439 was significantly upregulated in bladder cancer samples.Cell assays showed that hsa_circ_0137439 knockdown contributed to the inhibition of cell proliferation and migration via hsa_circ_0137439/miR-142-5p/ MTDH axis. Moreover, increased expression of hsa_circ_0137439 was correlated with higher tumor stage, higher tumor grade, higher lymph node status, and history of muscle-invasive bladder cancer (MIBC). Additionally, hsa_circ_0137439 in urine supernatant could serve as an independent prognostic predicator of recurrence-free survival and overall survival for patients with bladder cancer. Yes Cell assays showed that hsa_circ_0137439 knockdown contributed to the inhibition of cell proliferation and migration via hsa_circ_0137439/miR-142-5p/ MTDH axis. 31777254 circZKSCAN1 CircRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cell lines Regulation[miR-1178-3p/p21 axis] RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//FISH//Luciferase Report Assay//Invasion Assay Here, we found that circ-ZKSCAN1 was downregulated in BCa tissues and cell lines.Mechanistically, we demonstrated that circ-ZKSCAN1 upregulated p21 expression by sponging miR-1178-3p, which suppressed the aggressive biological behaviors in bladder cancer. Circ-ZKSCAN1 levels were associated with survival, tumor grade, pathological T stage and tumor recurrence. Yes Overexpressed circ-ZKSCAN1 inhibits cell proliferation, migration, invasion and metastasis in vitro and in vivo. 31481066 circPICALM CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Interaction[sponges miR-1265] Co-IP//qRT-PCR//Luciferase Report Assay CircPICALM was downregulated in BC tissues.CircPICALM can inhibit BC metastasis and bind to miR-1265 to block its pro-invasion activity. CircPICALM was downregulated in BC tissues, and low circPICALM expression was related to advanced T stage, high grade, lymph node positivity and poor overall survival. Yes Overexpression of circPICALM inhibited the metastasis of BC cells, and DHX9 negatively regulated circPICALM levels. 31648990 hsa_circ_0002024 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines Interaction[sponging miR-197-3p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that the expression of hsa_circ_0002024 was downregulated, but that of miR-197-3p was upregulated in BC tissues and cell lines.In conclusion, our data demonstrated that hsa_circ_0002024 suppresses cell proliferation, migration, and invasion in BC by sponging miR-197-3p. Yes Upregulation of hsa_circ_0002024 suppressed the proliferation, migration, and invasion of EJ and T24 cells. 30972190 hsa_circ_0006332 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction[modulating MYBL2 expression via miR-143] qRT-PCR//Luciferase Report Assay//FISH Direct Sanger sequencing and quantitative RT-PCR analysis showed that circ_0006332 was significantly upregulated in bladder cancer tissues.Our study demonstrates that circ_0006332 promotes the growth and progression of bladder cancer by modulating MYBL2 expression by acting as a sponge for miR-143. Circ_0006332 is thus a potential early diagnostic marker of bladder cancer. Yes Circ_0006332 knockdown increased E-cadherin levels and decreased Vimentin, CCNB1 and P21 protein expression. This suggests that circ_0006332 promotes epithelial-mesenchymal transition and cell cycle progression. In vivo experiments in nude mice showed that circ_0006332 knockdown bladder cancer cells form significantly smaller tumors than the controls. 31756170 hsa_circ_0000735 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cells interaction[sponges miR-502-5p] CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay Circ_0000735 expression was increased in bladder cancer tissues and cells compared with paraneoplastic tissues and normal cells, and miR-502-5p expression was reduced (both P<0.05). Circ_0000735 can adsorb miR-502-5p to promote bladder cancer cell proliferation and invasion and inhibit apoptosis. Yes Circ_0000735 silencing prevented cell proliferation and invasion and facilitated apoptosis (all P<0.05). 33425100 hsa_circ_0004463 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder carcinoma tissue and cells regulation[circ_0004463/miR-380-3p/FOXO1 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay circ_0004463 is significantly downregulated, whereas miR-380-3p is upregulated in bladder carcinoma tissue samples and cells. In conclusion, the circ_0004463/miR-380-3p/FOXO1 axis could regulate mitochondrial respiration and bladder cancer cell apoptosis via FOXO1 signaling. Yes Circ_0004463 overexpression inhibits cancer cell proliferation and mitochondrial respiration in bladder cancer cell lines, while miR-380-3p overexpression dramatically reverses the roles of circ_0004463 overexpression. 33283616 circRIMS1 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissue and cell lines regulation[ circRIMS1/miR-433-3p/CCAR1 regulatory axis ] RNA Pull-Down//Western Blot//qRT-PCR//FISH//Transwell Assay We further verified by qRT-PCR that circRIMS1 is upregulated in both bladder cancer tissue and cell lines.Taken together, our research demonstrated that circRIMS1 promotes tumor growth, migration, and invasion through the miR-433-3p/CCAR1 regulatory axis, representing a potential therapeutic target and biomarker in bladder cancer. Yes Inhibition of circRIMS1 suppressed the proliferation, migration, and invasion of bladder cancer cells both in vitro and in vivo. 33230478 hsa_circ_100146 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cell lines regulation[RNF2] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay Our data showed that circRNA_100146 expression was increased in bladder cancer tissues and cell lines, and that high expression of circRNA_100146 was correlated with poor patient prognosis. Our findings indicate that circRNA_100146 functions as a sponge of miR-149-5p in promoting bladder cancer progression by regulating RNF2 expression and that circRNA_100146 may serve as a novel biomarker in human bladder cancer. Our data showed that circRNA_100146 expression was increased in bladder cancer tissues and cell lines, and that high expression of circRNA_100146 was correlated with poor patient prognosis. Yes Upregulation of circRNA_100146 promoted cell proliferation, migration, and invasion, and inhibited cell apoptosis, whereas knockdown of circRNA_100146 displayed opposite effects on bladder cancer cells. 33149615 circFUT8 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder tissues regulation[miR-570-3p/KLF10 axis] RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//FISH//Luciferase Report Assay Quantitative real-time PCR analysis demonstrated that circFUT8 was downregulated in BCa tissues and correlated with patients' prognosis, histological grade, and lymph node (LN) metastasis.In conclusion, circFUT8 functions as a tumor suppressor in BCa cells by targeting the miR-570-3p/KLF10 axis and may serve as a potential biomarker and therapeutic target for the management of BCa patients with LN metastasis. Quantitative real-time PCR analysis demonstrated that circFUT8 was downregulated in BCa tissues and correlated with patients' prognosis, histological grade, and lymph node (LN) metastasis. Yes Functionally, gain- and loss-of-function assays indicated that circFUT8 inhibited the migration and invasion of BCa cell lines in vitro and LN metastasis in vivo. 32072011 hsa_circ_103809 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines regulation[miR-516a-5p/FBXL18 Axis] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay circRNA_103809 was highly expressed in BC tissues and cell lines.circRNA_103809 promotes proliferation, migration, invasion and chemo-resistance of BC cells through regulating miR-516a-5p/FBXL18 axis. CircRNA_103809 high expression was associated with a poor progression in BC patients. Yes CircRNA_103809 knockdown impaired the growth and metastasis of BC cells. 32922071 circBC048201 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cells regulation[miR-1184/ITGA3 axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Western Blot circBC048201 was abnormally highly expressed in bladder cancer tissues and cells, and the interference with circBC048201 inhibited bladder cancer cell proliferation, migration, and invasion. In summary, our results showed that circBC048201 was abnormally highly expressed in bladder cancer tissues and cells, and the interference with circBC048201 inhibited the proliferation, migration, and invasion of bladder cancer cells through the miR-1184/ITGA3 axis. Yes circBC048201 was abnormally highly expressed in bladder cancer tissues and cells, and the interference with circBC048201 inhibited bladder cancer cell proliferation, migration, and invasion. 32789658 hsa_circ_0008532 CircRNA Homo sapiens Urinary Bladder Neoplasms BC cell lines and tissues regulation[miR-155-5p/miR-330-5p/MTGR1 axis] Western Blot//FISH//qRT-PCR//RIP//Luciferase Report Assay We found that circ_0008532 is upregulated in BC cell lines and tissues. Circ_0008532 may act as an oncogene in BC through a novel circ_0008532/miR-155-5p, miR-330-5p /MTGR1/Notch pathway axis, which in turn may provide potential biomarkers and a therapeutic target for the management of bladder cancer. Yes Moreover, overexpression of circ_0008532 promotes, and silencing of circ_0008532 inhibits the capacity for invasive in BC cells. 32460831 circKIF4A CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cell lines regulation[circKIF4A-miR-375/1231-NOTCH2 axis] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Detected by qRT-PCR analysis, circKIF4A was significantly upregulated in bladder cancer tissues and cell lines.Generally, our research unveils the essential role of circKIF4A-miR-375/1231-NOTCH2 axis in bladder cancer progression possibly via the competing endogenous RNA mechanism. Yes Functionally, knockdown of circKIF4A inhibited the proliferation and colony-formation ability of bladder cancer cells. 32457613 hsa_circ_0067934 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues regulation[miR-1304] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay circ_0067934 expression levels were significantly increased in bladder cancer tissues (P<0.001), which was associated with metastasis and a significantly decreased 5-year overall (P<0.05) and disease-free survival (P<0.05). In conclusion, circ_0067934 was demonstrated to increase bladder cancer cell proliferation, migration and invasion through promoting Myc expression levels via the suppression of miR-1304 expression. circ_0067934 expression levels were significantly increased in bladder cancer tissues (P<0.001), which was associated with metastasis and a significantly decreased 5-year overall (P<0.05) and disease-free survival (P<0.05). Yes In vitro, T24 cells in the small interfering RNA (si)circ_0067934 group demonstrated significantly reduced proliferation, migration and invasion abilities compared with the si negative control (siNC) group (P<0.01). 32346439 circRGNEF CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues regulation[miR-548/KIF2C axis] CCK8//qRT-PCR//FISH//Luciferase Report Assay//EdU Staining Expression profile analysis of human circRNAs in BC revealed that circRGNEF was upregulated significantly.In summary, the data illustrate that circRGNEF suppresses BC progression by functioning as a miR-548 sponge to enhance KIF2C expression. Yes The downregulation of circRGNEF suppressed BC cell metastasis and proliferation by targeting the miR-548/KIF2C axis in vitro and in vivo; these results were verified with luciferase reporter assays. 32305958 hsa_circ_102336 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissue samples and cell lines interaction[sponging miR-515-5p] qRT-PCR Circ_102336 was identified to be sharply increased in both BC tissue samples and cell lines, and increased circ_102336 is correlated with a worse overall survival rate of BC patients.therefore, we suggested that circ_102336 indirectly regulate apoptosis and ABC transport pathways through miR-515-5p to finally modulate BC cell proliferation and chemo-resistance. Circ_102336 was identified to be sharply increased in both BC tissue samples and cell lines, and increased circ_102336 is correlated with a worse overall survival rate of BC patients. Yes Overexpression of circ_102336 dramatically increased the cell proliferation viability of T24 and 5637 cells, while knockdown of circ_102336 exhibited opposite effects. 32208321 hsa_circ_0058063 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues regulation[miR-486-3p/FOXP4 axis] qRT-PCR//Luciferase Report Assay//RIP circRNA_0058063 was overexpressed in BC tissues compared with adjacent normal tissues.Taken together, circRNA_0058063 functions by sponging miR-486-3p in BC progression, which could act as a new biomarker and further developed to be a therapeutic target in BC. Yes Knockdown of circRNA_0058063 dramatically decreased cell proliferation and invasion, and promoted apoptosis in 5637 and BIU-87 cell lines. 32181485 hsa_circ_0032822 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tumor tissues Interaction(miR-141/EF3 Signaling Axis) In Vivo Experiment//qRT-PCR//Luciferase Report Assay//Western Blot In this study, we confirmed the upregulation of circ_0032822 in HNSCC tumor tissues. Mechanistic analysis showed that circ_0032822 acted as a competing endogenous RNA of miR-141 to diminish the repressive effect of miR-141 on its target E2F3. Yes Functionally, the overexpression of circ_0032822 significantly promoted the proliferation of HNSCC cell lines along with the S phase arrest and reduced apoptosis, while downregulation of circ_0032822 has the opposite effect in vitro. 33981611 circPARD3 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues and cell lines Interaction(circPARD3/miR-5194/ENO1) CCK8//qRT-PCR//RIP//Western Blot Upregulated circPARD3 observed in HNSCC tissues and cell lines indicated the poor prognosis of patients. Mechanistically, circPARD3 harbored miR-5194, serving as a miRNA sponge, thereby increasing ENO1 expression. Moreover, ENO1 evidently reversed miR-5194-mediated attenuated malignant behaviors. Upregulated circPARD3 observed in HNSCC tissues and cell lines indicated the poor prognosis of patients. Yes Stable knockdown of circPARD3 dramatically exerted the suppressive effects on cell viability, proliferation, migration, and invasion, as well as glucose uptake and lactate production. 35900705 circBNC2 CircRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues Interaction(miR-223-3p/ LARP4 axis) qRT-PCR The expression of circBNC2 and LARP4 was decreased in EOC tissues, while the expression of miR-223-3p was increased. CircBNC2 can sponge miR-223-3p, and LARP4 is the target of miR-223-3p. In-vitro complement experiments showed that overexpression of circBNC2 significantly decreased the malignant behavior of EOC, while co-transfection of miR-223-3p mimics partially upregulated this change. Mechanically, circBNC2 regulates LARP4 expression in EOC cells by spongy miR-223-3p. Yes In addition, LARP4 knockdown increased the proliferation, migration, and invasion of EOC cells inhibited by miR-223-3p inhibitor. 36730544 hsa_circ_0000253 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(miR-1236-3p/SP1 axis) BrdU//qRT-PCR Circ_0000253 was upregulated in OS tissues and cell lines. Circ_0000253 targeted miR-1236-3p directly and negatively modulated its expression. SP1 was miR-1236-3p's target gene and positively regulated by circ_0000253. Yes Circ_0000253 overexpression facilitated OS cell growth and suppressed apoptosis, whereas knocking down circ_0000253 inhibited OS cell growth and facilitated apoptosis. 36444162 hsa_circ_0097271 CircRNA Homo sapiens Osteosarcoma OS samples and cells Interaction(miR-640/MCAM Pathway) qRT-PCR//Western Blot Circ_0097271's expression was enhanced in OS samples and cells. Circ_0097271 targeted miR-640 and negatively modulated miR-640 expression. MiR-640 was poorly expressed in OS, and its depletion recovered OS cell growth and migration that were repressed by circ_0097271 knockdown. MiR-640 bound to MCAM 3'UTR and thus suppressed MCAM expression. MCAM knockdown repressed OS cell growth and migration, while additional miR-640 depletion partially abolished the anticancer effects of MCAM knockdown in OS cells. Yes The knockdown of circ_0097271 restrained OS cell growth and migration, and its downregulation also blocked solid tumor growth in vivo. 36340580 hsa_circ_0051079 CircRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(circ_0051079/miR-1286/MAFB axis ) qRT-PCR//Luciferase Report Assay Circ_0051079 expression was upregulated in OS. Circ_0051079 interacted with miR-1286, and the tumor-inhibitory function of si-circ_0051079 was abolished by miR-1286 inhibition in OS cells. MAFB served as a target for miR-1286. OS cell progression was suppressed by miR-1286 overexpression via downregulating MAFB. Circ_0051079/miR-1286 resulted in expression change of MAFB in OS cells. Silencing circ_0051079 inhibited tumor growth in vivo via regulating the miR-1286/MAFB axis. Yes Downregulation of circ_0051079 reduced OS cell proliferation, migration, invasion, and accelerated apoptosis. 36153605 hsa_circ_0136666 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(miR-1244/CEP55 axis) qRT-PCR//Western Blot Circ_0136666 expression was prominently elevated in OS tissues and cell lines. Circ_0136666 negatively regulated miR-1244 expression by binding to it in OS cells. MiR-1244 overexpression suppressed the malignant behaviors of OS cells. CEP55 was a target of miR-1244 in OS cells. Circ_0136666 positively regulated CEP55 expression partly by sequestering miR-1244 in OS cells. Yes Circ_0136666 absence restrained the proliferation, migration, invasion and glycolytic metabolism and promoted the apoptosis of OS cells. CEP55 overexpression largely reversed circ_0136666 silencing-mediated influences in OS cells. Circ_0136666 silencing significantly suppressed tumor growth in vivo. 36109749 circFOXM1 CircRNA Homo sapiens Osteosarcoma OS cells Interaction(miR-320a and miR-320b/Wnt signaling pathway) qRT-PCR//RIP High expression of circ-FOXM1 was detected in OS cell lines. From the aspect of molecular mechanism, circ-FOXM1 was discovered to upregulate FOXM1 expression via sponging miR-320a and miR-320b, therefore activating Wnt signaling pathway. Besides, rescue experiments elucidated that circ-FOXM1 regulated cellular activities of OS cells via FOXM1. Yes Functionally, circ-FOXM1 knockdown inhibited the proliferation, migration and EMT process, whereas induced the apoptosis of OS cells. Further, in vivo assays supported that loss of circ-FOXM1 restrained OS tumor growth. 35799265 circNASP CircRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-1253/FOXF1) qRT-PCR//Luciferase Report Assay In the present study, we screened out a novel circRNA termed circNASP which was significantly upregulated in OS tissues compared to adjacent normal tissues. Taken together, our findings demonstrated that circNASP contributes to malignant behaviors of OS cells by miR-1253/FOXF1 pathway, which suggested circNASP/miR-1253/FOXF1axis might be a potential therapeutic target. Moreover, we showed that circNASP expression was positively correlated with tumor size and metastasis in OS patients. Yes We found that circNASP knockdown dramatically inhibited the proliferation, cell cycle progression and invasion of OS cells. 29678578 hsa_circ_0070441 CircRNA Homo sapiens Parkinson Disease SH-SY5Y cells Interaction(miR-626/IRS2 axis) RNA Pull-Down//Western Blot//qRT-PCR//RIP//ELISA The levels of circ_0070441 and IRS2 were increased while miR-626 expression was decreased in MPP+-treated SH-SY5Y cells in dose- and time-dependent manners.In summary, circ_0070441 aggravated MPP+-triggered neurotoxic effect in SH-SY5Y cells by regulating miR-626/IRS2 axis. Yes Depletion of circ_0070441 alleviated MPP+-triggered neuronal damage by regulating cell apoptosis and inflammation. 34748128 hsa_circ_0004381 CircRNA Homo sapiens Parkinson Disease SK-N-SH cells Interaction(miR-185-5p/RAC1 Axis) qRT-PCR//ELISA Hsa_circ_0004381 and RAC1 were increased, and miR-185-5p was decreased in MPP+-triggered SK-N-SH cells. The mechanical analysis suggested that hsa_circ_0004381 served as a sponge of miR-185-5p to affect RAC1 expression. Hsa_circ_0004381 could contribute to MPP+-triggered neuron injury by targeting the miR-185-5p/RAC1 axis, which provided a novel insight into the pathogenesis and treatment of PD. Yes Moreover, hsa_circ_0004381 silencing promoted cell viability, and repressed apoptosis, inflammatory response, and oxidative stress in MPP+-treated SK-N-SH cells. 35726081 circHIPK3 CircRNA Homo sapiens Parkinson Disease human serum and cerebral fluids Interaction(miR-124-3p/STAT3/NLRP3 signaling pathway ) Western Blot//qRT-PCR//RIP//FISH//ELISA The expression of circHIPK3 in human serum and cerebral fluids was significantly higher than in controls, whereas miR-124 expression was drastically reduced. In addition, lipopolysaccharide (LPS)-treated BV2 cells exhibited higher expression of circHIPK3 and lower miR-124 expression. The upregulation of circHIPK3 increased IL-6, IL-1β and TNF-α secretion in BV2 cells. The protein expressions of microglia markers (CD11b and Iba-1), as well as pyroptosis-related factors, NLRP3, caspase-1, and ASC, were also increased following the expression of circHIPK3. All these effects were reversed by the addition of miR-124. Yes The SH-SY5Y cells exhibited a significantly impaired viability and elevated apoptotic rate, along with an upregulation of circHIPK3 and a downregulation of miR-124 expression after being treated with supernatants collected from LPS-treated BV2 cells. 36306116 circTLK1 CircRNA Homo sapiens Parkinson Disease PD models Interaction(miR-26a-5p/DAPK1) qRT-PCR//Luciferase Report Assay The expression of circTLK1 was notably elevated in in vitro and in vivo PD models.MiR-26a-5p acts as a sponge of DAPK1 to mediate circTLK1 functions. Luciferase reporter gene assay confirmed the interaction between circTLK1 and miR-26a-5p as well as miR-26a-5p and DAPK1. Yes Knockdown of circTLK1 significantly improved cell viability, suppressed apoptosis and cytotoxicity, whereas inhibition of miR-16a-5p and overexpression of DAPK1 abolished these effects. 35447224 circzip-2 CircRNA Homo sapiens Parkinson Disease worms Interaction [miR-60] qRT-PCR//RNA-seq We went on to sequence circzip-2 which is synthesized from functionally important gene zip-2. Studying RNAi-induced knockdown conditions of zip-2, we observed a reduced aggregation of α-synuclein protein along with an enhanced lifespan of the worms. We further carried out transcriptome analysis of zip-2 silenced worms, which suggested that zip-2 might be functioning via Daf-16 pathway. Further interaction studies revealed that circzip-2 possibly sponges microRNA molecule miR-60 towards asserting an important role in various processes associated with PD. Yes Studying RNAi-induced knockdown conditions of zip-2, we observed a reduced aggregation of α-synuclein protein along with an enhanced lifespan of the worms. 29363043 hsa_circ_0009910 CircRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow aspiration Interaction[miR-20a-5p] RNA Pull-Down//CCK8//FISH//Luciferase Report Assay//Microarray Furthermore, we found that circ_0009910 was significantly upregulated in AML patients compared with iron-deficiency anemia patients. Further experiments in vitro and in vivo demonstrated that knockdown of circ_0009910 inhibited AML cell proliferation and induced apoptosis through sponging miR-20a-5p. Our findings firstly identify that circ_0009910 is significantly upregulated in AML bone marrow samples and might serve as a novel outcome biomarker for AML. Both circ_0009910 and miR-20a-5p may be potential therapeutic targets for future AML treatment. High circ_0009910 expression predicted a poor risk and outcome of AML patients. Yes Further experiments in vitro and in vivo demonstrated that knockdown of circ_0009910 inhibited AML cell proliferation and induced apoptosis through sponging miR-20a-5p. 30612066 hsa_circ_0079480 CircRNA Homo sapiens Leukemia, Myeloid, Acute regulation[miR-654-3p/HDGF axis] CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining In this analysis, hsa_circ_0079480, a novel circRNA, has been identified as being highly expressed in AML. In summary, hsa_circ_0079480 is highly expressed in AML and drives by tumor progression via regulation of hsa_circ_0079480/miR-654-3p/HDGF axis, indicating that hsa_circ_0079480 may function as a new treatment target for AML therapy. Yes Loss-of-function assays showed that reduction of hsa_circ_0079480 decreased the growth and stimulated apoptosis of AML cells in vitro. 33290265 hsa_circ_0002483 CircRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow,cell line regulation[miR-758-3p/MYC axis] CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay Circ_0002483 expression was elevated in AML patients and cells.Circ_0002483 knockdown repressed AML cell proliferation and promoted cycle arrest and apoptosis via controlling miR-758-3p/MYC axis. Yes Circ_0002483 silence constrained AML cell proliferation and facilitated cell cycle arrest and apoptosis. 33283885 circPTK2 CircRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow regulation[miR-330-5p/FOXM1 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay Circ-PTK2 was highly expressed in AML. Circ-PTK2 promoted the proliferation and hampered the apoptosis of AML cells through targeting miR-330-5p/FOXM1 axis. Yes Circ-PTK2 interference suppressed the proliferation and triggered the apoptosis of AML cells. 33126007 circCRKL CircRNA Homo sapiens Leukemia, Myeloid, Acute AML cell lines and samples Interaction(miR-196a-5p/miR-196b-5p/p27 axis) qRT-PCR//RIP The results indicated low circCRKL expression in AML cell lines and samples. In addition, bioinformatics tools and luciferase assays revealed that circCRKL could sponge miR-196a-5p and miR-196b-5p to promote the expression of p27. Furthermore, circCRKL inhibited AML cell proliferation via the miR-196a-5p/miR-196b-5p/p27 axis, suggesting a potential new target for AML therapy. Yes Moreover, the overexpression of circCRKL inhibited the proliferation and colony-forming ability of AML cells, while its silencing promoted them. 34617876 hsa_circ_0005774 CircRNA Homo sapiens Leukemia, Myeloid, Acute blood of pediatric AML patients and AML cells Interaction(miR-192-5p/ULK1 ceRNA pathway) qRT-PCR//Luciferase Report Assay//RIP Real time-quantitative PCR revealed that circ_0005774 was highly expressed in blood of pediatric AML patients and AML cells (HL-60 and NB4), accompanied with downregulated miRNA-192-5p (miR-192-5p) which was a crucial tumor-associated and leukemia-related miRNA. Circ_0005774 was abundant in miRNA response element according to CSCD software, and miR-192-5p was identified as a target of circ_0005774, as evidenced by RNA immunoprecipitation and dual-luciferase reporter assays. Notably, ULK1 was a downstream target of miR-192-5p and indirectly modulated by circ_0005774. Yes Accordingly, blocking circ_0005774 and/or overexpressing miR-192-5p could enhance apoptosis rate of HL-60 and NB4 cells, but suppress cell viability and cell cycle entrance, accompanied with depression of proliferation markers including proliferating cell nuclear antigen (PCNA), CyclinD1 and B cell lymphoma 2 (Bcl-2). 33735626 circSPI1 CircRNA Homo sapiens Leukemia, Myeloid, Acute AML patients Interaction(miR-1307-3p, miR-382-5p, and miR-767-5p) CCK8//qRT-PCR//Western Blot Here, we found that circSPI1, the circular RNA derived from the SPI1 gene, is highly expressed in AML but not in normal counterparts. On one hand, circSPI1 contributes to myeloid differentiation of AML cells by interacting with the translation initiation factor eIF4AIII to antagonize PU.1 expression at the translation level. On the other hand, circSPI1 contributes to proliferation and apoptosis by interacting with miR-1307-3p, miR-382-5p, and miR-767-5p; this role is uncoupled with SPI1. Finally, we illustrate the clinical significance of circSPI1 by showing that circSPI1-regulated genes are associated with the clinical outcome of AML patients. Yes Unlike SPI1, a tumor suppressor and being lowly expressed in AML, we demonstrate that circSPI1 acts as an oncogene, evidenced by the observation that circSPI1 knockdown induces myeloid differentiation and apoptosis of AML cells. 33741901 hsa_circ_0001982 CircRNA Homo sapiens Osteosarcoma OS tissues and cells (MG63) Interaction(miR-143) qRT-PCR//Transwell Assay The expression of hsa_circ_0001982 was significantly increased in OS tissues and cells (MG63), as in well as chemoresistant OS tissues and cells (MG63/Dox). By contrast, knockdown of hsa_circ_0001982 markedly reduced the resistance of MG63/Dox cells to doxorubicin (IC50 evidently reduced). Bioinformatic prediction showed that miR-143 was a target miRNA of hsa_circ_0001982, and a dual-luciferase reporter assay proved this. Further experiments revealed that miR-143 expression was notably downregulated in OS tissues, chemoresistant OS tissues, and MG63/Dox cells. Moreover, miR-143 was negatively correlated with hsa_circ_0001982 in OS cells and tissues. Yes Overexpression of hsa_circ_0001982 promoted proliferation, colony formation, migration, invasion, and multidrug resistance in MG63 cells. 35576496 circNRIP1 CircRNA Homo sapiens Osteosarcoma OS cell lines Interaction(miR-1200/MIA2 ) qRT-PCR//IHC CircNRIP1 was mainly localized in OS cell cytoplasm and significantly lower in OS cell lines than in normal human osteoblasts. miR-1200 was predicted as the sponge miRNA of circNRIP1 and directly interacted with circNRIP1 confirmed by the dual-luciferase reporter assay. Moreover, miR-1200 overexpression significantly alleviated the inhibitory effect of circNRIP1 on OS cells. A protein-coding gene MIA2 was identified as the miR-1200 targeting gene and reversely associated with miR-1200 expression in OS cells. Increase in MIA2 expression in a murine OS cell xenograft model was associated with circNRIP1 expression in inhibition of OS cell xenograft growth in vivo. Yes CircNRIP1 overexpression significantly inhibited OS cell proliferation, migration, and invasion in vitro. 35812061 circPTK2 CircRNA Homo sapiens Leukemia, Myeloid, Acute AML peripheral blood samples and cells Interaction(miR-582-3p/ALG3 axis) qRT-PCR//MTT//RIP CircPTK2 level was enhanced in AML peripheral blood samples and cells.Mechanically, circPTK2 functioned as the sponge for miR-582-3p to positively ALG3 expression in AML cells. Moreover, miR-582-3p inhibition ameliorated the impacts of circPTK2 knockdown on AML cell processes. MiR-582-3p overexpression regulated cell phenotypes by targeting ALG3. Yes CircPTK2 knockdown restrained AML cell proliferation and glycolysis and promoted cell apoptosis and cell cycle arrest. 35980117 circSRSF4 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Interaction( circSRSF4/miR-224/Rac1 axis) CCK8//qRT-PCR The expression of circSRSF4 was significantly higher in osteosarcoma tissues and cell lines. A mechanistic study showed that circSRSF4 can be used as an miR-224 sponge to up-regulate the expression of Rac1, thereby promoting the development of osteosarcoma. Yes Down-regulating the expression of circSRSF4 in vitro significantly inhibited the proliferation, invasion, and migration of cells, and also reduced the expression of Rac1, while the overexpression of Rac1 and miR-224 inhibition could reverse these effects. The inhibition of circSRSF4 expression in vivo also attenuated tumor growth. 35682879 circMRPS35 CircRNA Homo sapiens Osteosarcoma osteosarcoma cells Interaction(KAT6B/FOXO3) qRT-PCR//Western Blot Mechanically, the depletion of circMRPS35 reduced the enrichment of histone H3 lysine 23 acetylation (H3K23ac) on forkhead box O3 (FOXO3) promoter in osteosarcoma cells. The interaction of circMRPS35 and KAT6B was identified. The knockdown of KAT6B reduced the enrichment of H3K23ac on FOXO3 promoter in osteosarcoma cells. Yes The colony formation numbers and Edu-positive osteosarcoma cells were repressed by the overexpression of circMRPS35. Meanwhile, the overexpression of circMRPS35 increased the apoptosis rate of osteosarcoma cells. The expression levels of autophagy markers, including LC3 and Beclin1, were enhanced by the overexpression of circMRPS35 in osteosarcoma cells.The overexpression of circMRPS35 inhibited the tumor growth in vivo , whereas the depletion of KAT6B could reverse the effect in the mice. 35503036 hsa_circ_0087302 CircRNA Homo sapiens Osteosarcoma osteosarcoma cells Regulation(Wnt/β-catenin) CCK8//qRT-PCR Using RT-PCR, we confirmed that the expression of hsa_circ_0087302 in osteosarcoma cells was lower than that in osteoblasts. Furthermore, Western blotting experiments demonstrated that hsa_circ_0087302 affected the expression of cell cycle- and Wnt/β-catenin signaling pathway-related proteins. Yes Functional validation experiments revealed that hsa_circ_0087302 overexpression inhibited proliferation, cell cycle, migration, and invasion in osteosarcoma cells. 36035366 hsa_circ_0069117 CircRNA Homo sapiens Osteosarcoma OS cell lines Interaction(miR-875-3p/PF4V1 ) qRT-PCR//Western Blot We identified hsa_circ_0069117 as the most markedly dysregulated circRNA in OS cell lines.Bioinformatics analysis indicated that hsa_circ_0069117 might inhibit the expression of miR-875-3p, thereby promoting the expression of platelet factor 4 variant 1 (PF4V1). Luciferase reporter gene assays confirmed the binding sites of miR-875-3p on hsa_circ_0069117 and PF4V1. The expression of miR-875-3p was negatively correlated to hsa_circ_0069117 and PF4V1 in clinical samples. Yes Gain/loss-of-function and rescue assays further indicated that hsa_circ_0069117 could significantly promote the expression of PF4V1 by sponging miR-875-3p, thereby inhibiting the proliferation and migration of OS cells by suppressing ERK1 and AKT. 35062989 circCSPP1 CircRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction( miR-200c ) qRT-PCR//RNA Pull-Down CircCSPP1 and premature miR-200c levels were increased while mature miR-200c level was decreased in OS. CircCSPP1 was detected in both the nuclear and cytoplasm fractions of OS cells. CircCSPP1 directly interacted with premature miR-200c. CircCSPP1 overexpression increased premature miR-200c level, glucose uptake, and cell proliferation, but decreased mature miR-200c level. MiR-200c overexpression suppressed the role of circCSPP1 in OS cells. Yes CircCSPP1 overexpression increased premature miR-200c level, glucose uptake, and cell proliferation, but decreased mature miR-200c level. 35713481 hsa_circ_0051079 CircRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-625-5p/TRIM66/Wnt/β-catenin) qRT-PCR Circ_0051079 and TRIM66 expressions were significantly upregulated, but miR-625-5p was downregulated in OS tissues and cells compared with control groups. MiR-625-5p, a target miRNA of circ_0051079, participated in regulating circ_0051079-induced effects. Also, TRIM66 was identified as a target mRNA of miR-625-5p, and partially attenuated the inhibitory effects of miR-625-5p in OS cells. Circ_0051079 modulated the Wnt/β-catenin pathway through TRIM66 in vitro. Importantly, circ_0051079 silencing reduced TRIM66 expression by interacting with miR-625-5p. Circ_0051079 expression was significantly associated with tumor-node-metastasis stage and tumor size of OS patients. Yes Circ_0051079 knockdown inhibited OS cell proliferation, migration and invasion, repressed angiogenesis but induced cell apoptosis, accompanied by the decreases of PCNA and Bcl-2 production and an increase of Bax production. Further, circ_0051079 depletion inhibited tumor formation in vivo. 35733786 hsa_circ_0001174 CircRNA Homo sapiens Osteosarcoma OS tissues and OS cell lines Interaction(miR-186-5p/MACC1 axis) Western Blot//Bioinformatics Analysis//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay the results were consistent with the sequencing data, and circ_0001174 was found to be significantly upregulated in 16 pairs of OS tissues and OS cell lines (fold change > 2.0, P value < 0.05). Additionally, circ_0001174 directly and negatively modulated the expression of miR-186-5p and positively regulated the expression of MACC1. Yes Knockdown of circ_0001174 inhibited the proliferation, migration, and invasion of OS cells. 35279159 circRASSF2 CircRNA Homo sapiens Osteosarcoma OS cells Interaction(miR-6838-5p) CCK8//qRT-PCR Compared with osteoblasts, OS cells showed lower expression of miR-6838-5p and higher expression of circRASSF2. The dual luciferase report confirmed that miR-6838-5p targeted IGF1R. Overexpression of IGF1R significantly blocked the anticancer effects of miR-6838-5p. The dual luciferase report verified that circRASSF2 targeted miR-6838-5p, and promoted the expression of IGF1R. Overexpression of circRASSF2 not only promoted the malignant biological behavior of OS cells, but also blocked the anticancer effects of miR-6838-5p. In OS tissue, circRASSF2 and IGF1R were upregulated, and the two were positively correlated. MiR-6838-5p was downregulated, which negatively correlated with both circRASSF2 and IGF1R. High levels of circRASSF2 were associated with higher stage and metastasis of OS. Yes Overexpression of IGF1R significantly blocked the anticancer effects of miR-6838-5p. 35242856 hsa_circ_0001017 CircRNA Homo sapiens Osteosarcoma OS cell lines & U2OS cells Interaction(miR-145-5p) qRT-PCR//MTT A total of 241 CDECs, including 75 upregulated and 166 downregulated CDECs, were identified in three OS cell lines compared with normal vascular endothelial cells. PCR validation showed that hsa_circ_0000704, hsa_circ_0001017 and hsa_circ_0005035 were all highly expression in the three OS cell lines, compared with osteoblast cell lines (HECC, hFOB1.19 and HFF-1). Functionally, overexpression of circ_0001017 significantly promoted the cell proliferation, migration and invasion and decreased apoptosis in U2OS cells. Knockdown of circ_0001017 obtained the opposite results. Circ_0001017 may downregulate miR-145-5p through direct binding. Furthermore, the expression of miR-145-5p was negatively regulated by circ_0001017 in OS cells. In addition, further functional studies indicated that miR-145-5p inhibitor eliminated the effects caused by si-circ_0001017 in OS cells. Yes Functionally, overexpression of circ_0001017 significantly promoted the cell proliferation, migration and invasion and decreased apoptosis in U2OS cells. Knockdown of circ_0001017 obtained the opposite results. 35346268 circUBAP2 CircRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(circ_UBAP2/miR-637/HMGB2 axis) CCK8//qRT-PCR Circ_UBAP2 showed high expression levels in OS tissues and cells, which was directly proportional to metastasis and clinical stage of OS. Furthermore, miR-637 served as a downstream target of circ_UBAP2, which played opposite roles to circ_UBAP2 in OS. More importantly, HMGB2 served as miR-637's downstream target. The xenograft experiments in nude mice also proved that knockdown of circ_UBAP2 could increase miR-637 expression, but decrease HMGB2 expression, thus alleviating OS progression. Mechanistically, circ_UBAP2 exerts a cancer-promoting effect on OS by downregulating miR-637 and upregulating the expression of HMGB2. Yes The overexpression of circ_UBAP2 enhanced the growth, invasion, and migration of OS cells, but suppressed their apoptosis. In contrast, circ_UBAP2 silencing had opposite effects. 35114890 circCYP51A1 CircRNA Homo sapiens Osteosarcoma OS cells Interaction(miR-490-3p/KLF12 axis) qRT-PCR//Western Blot CircCYP51A1 and KLF12 expression were dramatically increased, whereas miR-490-3p was decreased in OS cells under hypoxia condition. CircCYP51A1 enhanced KLF12 expression by sponging miR-490-3p. MiR-490-3p inhibitor weakened the inhibition effect of circCYP51A1 knockdown on the progression of OS under hypoxia. Besides, overexpression of miR-490-3p inhibited cell progression of OS under hypoxia condition, while the effects were attenuated by KLF12 overexpression. Yes Deficiency of circCYP51A1 hindered hypoxia-induced cell proliferation, migration, invasion and glycolysis in OS cells. 36276300 circCDK14 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(miR-198/E2F2 axis) Migration Assay//qRT-PCR//Cell Viability Assay//Invasion Assay//Transwell Assay Our data revealed that circ-CDK14 was up-regulated and miR-198 was down-regulated in OS tissues and cell lines. Mechanistically, circ-CDK14 directly targeted miR-198. Moreover, miR-198 was a functional mediator of circ-CDK14 in regulating OS cell progression in vitro. E2F2 was a direct target of miR-198, and miR-198 overexpression regulated OS cell progression in vitro by down-regulating E2F2. Furthermore, circ-CDK14 regulated E2F2 expression by functioning as a sponge of miR-198 in OS cells. Yes Circ-CDK14 silencing suppressed OS cell viability, migration, invasion, and glycolysis and promoted cell apoptosis in vitro, as well as diminished tumor growth in vivo. 35218724 hsa_circ_0078767 CircRNA Homo sapiens Osteosarcoma OS cell lines and tissues Interaction(miR-889/KLF9 ) qRT-PCR This study confirmed that circ_0078767 expression was reduced in OS cell lines and tissues. MicroRNA-889 (miR-889) was targeted and regulated by circ_0078767, and miR-889 could negatively modulate Kruppel-like factor 9 (KLF9) expression. Besides, circ_0078767 positively regulated KLF9 expression in OS cells via repressing miR-889. In conclusion, circ_0078767 enhances KLF9 expression by targeting miR-889 to inhibit OS progression. Yes Circ_0078767 overexpression remarkably inhibited OS cell growth, migration, invasion, epithelial-mesenchymal transition (EMT), and promoted apoptosis, whereas circ_0078767 knockdown resulted in the opposite effects. 35758280 circFIRRE CircRNA Homo sapiens Osteosarcoma osteosarcoma cell lines and tissues Interaction(miR-486-3p and miR-1225-5p/LUZP1) Bioinformatics Analysis In this article, a novel circular RNA, circFIRRE (hsa_circ_0001944) was screened out and identified from RNA-sequencing, and was upregulated in both osteosarcoma cell lines and tissues. Mechanistically, upregulated circFIRRE was induced by transcription factor YY1, and partially boosted the mRNA and protein level of LUZP1 by sponging miR-486-3p and miR-1225-5p. Clinically, aberrantly upregulated circFIRRE portended higher metastatic risk and worse prognosis in osteosarcoma patients. Yes " Functionally, in vitro, ex vivo and in vivo experiments demonstrated that circFIRRE could drive primary osteosarcoma progression and lung metastasis by inducing both tumor cells and blood vessels, we call as ""tumorigenic-angiogenic coupling"". " 35986280 circCTNNB1 CircRNA Homo sapiens Osteosarcoma OS tissues and cells Expression(highly expressed) qRT-PCR//Northern Blot//Western Blot Circ-CTNNB1 was highly expressed in OS tissues and predominantly detected in the nucleus of OS cells. Mechanistically, circ-CTNNB1 interacted with RBM15 and subsequently promoted the expression of hexokinase 2 (HK2), glucose-6-phosphate isomerase (GPI) and phosphoglycerate kinase 1 (PGK1) through N6-methyladenosine (m6A) modification to facilitate the glycolysis process and activate OS progression. Yes Ectopic expression of circ-CTNNB1 promoted the growth, invasion, and metastasis of OS cells in vitro and in vivo. 36181462 circTNPO1 CircRNA Homo sapiens Osteosarcoma OS cell lines Interaction(miR-338-3p) CCK8//qRT-PCR The RNA expression of circTNPO1 in OS cell lines U2OS, HOS, MG63, 143B, ZOS and ZOSM were 2.73±0.27, 3.18±0.54, 4.33±0.52, 5.75±0.65, 4.50±0.49 and 3.96±0.35, respectively, higher than 1.00±0.09 in hFOB1.19 (P<0.001).CircTNPO1 promotes the proliferation and metastasis of OS by sponging miR-338-3p, which could be a new target for OS treatments. Yes CCK-8 assay revealed that after 48 h and 72 h, the absorbance of sh-circTNPO1 #1 was 0.81±0.05 and 1.09±0.06, while sh-circTNPO1 #2 143B cells was 0.84±0.04 and 1.2±0.04, which were sharply reduced compared with the control (1.00±0.06 and 1.49±0.06, P<0.001); after 48 h and 72 h, the absorbance of 143B cells transfected with circTNPO1 #1 and miR-338-3p (0.92±0.06 and 1.32±0.07) were higher than those of cells transfected with sh-circTNPO1 cells and miR NC (0.92±0.06 and 1.32±0.07, P<0.050). Wound healing assay demonstrated that the 24 hour-migration rates of sh-circTNPO1 #1 and sh-circTNPO1 #2 cells were (24.43±2.15)% and (39.70±4.20)% respectively, which were significantly lower than that of the control [(56.51±3.27)%, P<0.010]; the migration rates of sh-circTNPO1 #1+ miR NC and sh-circTNPO1 #1+ miR-338-3p inhibitor were (26.70±2.21)% and (46.10±5.71)%, with a significant difference (P<0.005). In xenograft tumor model, the weight and size of tumors in control, sh-circTNPO1 #1+ miR NC and sh-circTNPO1 #1+ miR-338-3p inhibitor mice were (458.80±158.10) mg, (262.50±82.09) mg, (395.40±137.60) mg and (593.00±228.40) mm(2,) (203.30±144.20) mm(2,) (488.60±208.60) mm(2,) respectively. Compared with control, sh-circTNPO1 tumors were significantly smaller (P<0.01). 36164699 circAGFG1 CircRNA Homo sapiens Osteosarcoma osteosarcoma cells Interaction(miR-302a/LATS2) In Vivo Experiment//qRT-PCR The expression level of circAGFG1 was upregulated in osteosarcoma cells. CircAGFG1 was specifically bound to miR-302a to regulate the expression activity of miR-302a. MiR-302a specifically bound to the 3'UTR of LATS2 and inhibited the expression of LATS2. The overexpression of miR-302a reversed the effect of circAGFG1 on the proliferation, invasion, and migration of osteosarcoma cells. CircAGFG1 regulated the expression of LATS2 by miR-302a, thereby regulating the proliferation, migration, and invasion of osteosarcoma cells. Yes The downregulation of circAGFG1 inhibited the proliferation, invasion, and migration of osteosarcoma cells. The overexpression of circAGFG1 enhanced the stemness of osteosarcoma cells. 35958928 circLRP6 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(miR‑141‑3p/HDAC4/HMGB1 axis) qRT-PCR//Luciferase Report Assay The results confirmed that circ?LRP6 was highly expressed in OS tissues and cell lines. In addition, circ‑LRP6 negatively regulated the expression of miR‑141‑3p and, in turn, miR‑141‑3p negatively regulated HDAC4 and HMGB1 expression. Yes Functional assays revealed that circ?LRP6 knockdown inhibited the proliferation, migration and invasion of OS cells, whereas the inhibition of miR?141?3p or the overexpression of either HDAC4 or HMGB1 partly reversed the inhibitory effect of circ?LRP6 knockdown. 35211755 circKIF4A CircRNA Homo sapiens Osteosarcoma OS cells and tissues Interaction(miR-515-5p/SLC7A11) qRT-PCR//Transwell Assay In both OS cells and tissues, circKIF4A (hsa_circ_0007255) was found to be upregulated. circKIF4A enhanced OS growth as well as metastasis by sponging miR-515-5p and by upregulating SLC7A11. Yes In vitro and in vivo, circKIF4A knockdown markedly suppressed OS proliferation as well as metastasis. 35579738 hsa_circ_0003732 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells Interaction(miR-377-3p/CPEB1 axis ) qRT-PCR//Western Blot Circ_0003732 was upregulated in osteosarcoma tissues and cells. Meanwhile, miR-377-3p could bind to circ_0003732 and CPEB1 and miR-377-3p inhibitor could reverse the effects of circ_0003732 silence on osteosarcoma cell progression. Furthermore, CPEB1 overexpression could overturn the suppressive impacts of miR-377-3p on osteosarcoma progression. In addition, circ_0003732 silence restrained Wnt/β-catenin signaling pathway via regulating miR-377-3p in osteosarcoma cells. Yes Knockdown of circ_0003732 suppressed osteosarcoma cell proliferation, migration, invasion and triggered cell apoptosis in vitro, as well as reduced osteosarcoma tumor growth in vivo. 34407049 hsa_circ_0040823 CircRNA Homo sapiens Leukemia, Myeloid, Acute AML patients and leukemia cells Interaction(miR-516b/PTEN) qRT-PCR//Western Blot circ_0040823 was significantly downregulated in AML patients and leukemia cells. circ_0040823 acted as a miR-516b sponge and regulated key cellular events in leukemia cells via downregulating miR-516b. Moreover, tumor suppressor phosphatase and tensin homolog (PTEN) was a downstream target of miR-516b. The inhibition of miR-516b impaired the proliferation capacity of leukemia cells and induced apoptosis, while PTEN deficiency attenuated these effects. Yes Overexpression of circ_0040823 inhibited AML cell proliferation, and induced apoptosis and cell cycle arrest. Upregulation of circ_0040823 also repressed the growth of xenograft tumors in vivo. 34913223 hsa_circ_0059706 CircRNA Homo sapiens Leukemia, Myeloid, Acute leukemia cells Expression(lower expressed) qRT-PCR We found that circ_0059706 expression was significantly lower in AML patients than in controls (p < 0.001). Survival analysis of patients with AML divided into two groups according to high and low circ_0059706 expression showed that overall survival (OS) of patients with high circ_0059706 expression was significantly longer than that of those with low expression (p < 0.05). Further, female patients with AML and those aged >60 years old in the high circ_0059706 expression group had longer OS than male patients and those younger than 60 years. Multiple regression analysis showed that circ_0059706 was an independent factor-affecting prognosis of all patients with AML. To evaluate the prospects for application of circ_0059706 in machine learning predictions, we developed seven types of algorithm. The gradient boosting (GB) model exhibited higher performance in prediction of 1-year prognosis and 3-year prognosis, with AUROC 0.796 and 0.847. We analyzed the importance of variables and found that circ_0059706 expression level was the first important variables among all 26 factors included in the GB algorithm, suggesting the importance of circ_0059706 in prediction model. Further, overexpression of circ_0059706 inhibited cell growth and increased apoptosis of leukemia cells in vitro. We found that circ_0059706 expression was significantly lower in AML patients than in controls (p < 0.001). Survival analysis of patients with AML divided into two groups according to high and low circ_0059706 expression showed that overall survival (OS) of patients with high circ_0059706 expression was significantly longer than that of those with low expression (p < 0.05). Further, female patients with AML and those aged >60 years old in the high circ_0059706 expression group had longer OS than male patients and those younger than 60 years. Multiple regression analysis showed that circ_0059706 was an independent factor-affecting prognosis of all patients with AML. To evaluate the prospects for application of circ_0059706 in machine learning predictions, we developed seven types of algorithm. The gradient boosting (GB) model exhibited higher performance in prediction of 1-year prognosis and 3-year prognosis, with AUROC 0.796 and 0.847. We analyzed the importance of variables and found that circ_0059706 expression level was the first important variables among all 26 factors included in the GB algorithm, suggesting the importance of circ_0059706 in prediction model. Yes urther, overexpression of circ_0059706 inhibited cell growth and increased apoptosis of leukemia cells in vitro. 36338954 circMAT2B CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues and cell lines Interaction(miR-491-5p/ASCT2 axis) CCK8//qRT-PCR Remarkably overexpressed circMAT2B was observed in HNSCC tissues and cell lines, of which high abundance was positively correlated with patients' poor prognosis. miR-491-5p, interacted with ASCT2, was identified to be a downstream target of circMAT2B, thereby involving in circMAT2B-mediated biological effects. In summary, we draw a conclusion that circMAT2B could modulate the processes of cell proliferation, migration, invasion, and glutaminolysis of HNSCC cells partly via the miR-491-5p/ASCT2 axis by a molecular mechanism of competing endogenous RNA (ceRNA), implying an underlying circRNA-targeted therapy for HNSCC treatment. Remarkably overexpressed circMAT2B was observed in HNSCC tissues and cell lines, of which high abundance was positively correlated with patients' poor prognosis. Yes Silencing of circMAT2B inhibited cell proliferation, migration, and invasion, as well as glutaminolysis. 36219356 hsa_circ_0007534 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues Interaction[sponging miR-625 and miR-892b] qRT-PCR//Luciferase Report Assay As a result, circ_0007534 was overexpressed not only in PDAC tissues but also in a panel of PDAC cell lines, and this overexpression is closely associated with advanced tumor stage and positive lymph node invasion. Mechanistically, miR-625 and miR-892b were sponged by circ_0007534. The oncogenic functions of circ_0007534 is partly dependent on its regulation of miR-625 and miR-892b. As a result, circ_0007534 was overexpressed not only in PDAC tissues but also in a panel of PDAC cell lines, and this overexpression is closely associated with advanced tumor stage and positive lymph node invasion. Yes For the part of functional assays, circ_0007534 significantly increased cell proliferation, migratory, and invasive potential of PDAC cells. 30382592 circFOXK2 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues interaction[Sponging MiR-942] RNA Pull-Down//qRT-PCR//circRNA-seq//RIP//Luciferase Report Assay Among them, circFOXK2 was validated with significant upregulation in PDAC cells and 63% of primary tumors (53 of 84).circFOXK2 promoted cell growth, migration, and invasion and was involved in cell-cycle progression and apoptosis. circFOXK2 contained multiple miRNA binding sites, functioning as a sponge for miR-942, which in turn promoted expression of ANK1, GDNF, and PAX6. Yes circFOXK2 promoted cell growth, migration, and invasion and was involved in cell-cycle progression and apoptosis. 32217695 circBFAR CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues regulation[ miR-34b-5p/MET/Akt axis] qRT-PCR//RNA Pull-Down//EdU Staining//Transwell Assay In the present study, we identified a novel circRNA (termed as circBFAR, hsa_circ_0009065) that was upregulated in a 208-case cohort of patients with PDAC. Additionally, circBFAR overexpression increased the expression of MET and activated downstream phosphorylation of Akt (Ser 473) and further activated the MET/PI3K/Akt signaling pathway, which ultimately promoted the progression of PDAC cells. The ectopic expression of circBFAR correlated positively with the tumor-node-metastasis (TNM) stage and was related to poorer prognosis of patients with PDAC. Yes Moreover, circBFAR knockdown dramatically inhibited the proliferation and motility of PDAC cells in vitro and their tumor-promoting and metastasis properties in in vivo models. 32375768 hsa_circ_000684 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues and cells Interaction(miR-145 ) CCK8//qRT-PCR//Bioinformatics Analysis Expression of CircRNA_000684 and KLF5 was upregulated, whereas miR-145 expression was downregulated in PDAC tissues and cells. Taken together, the present study provided evidence clarifying that circRNA_000684 could downregulate miR-145 expression and elevate KLF5 to promote the progression of PDAC. Yes CircRNA_000684 repression or miR-145 elevation inhibited the proliferation, invasion and migration of PDAC cells and HUVEC angiogenesis, as evidenced by lower levels of MCM2, MMP2 and MMP9 and VEGFA. In-vivo, circRNA_000684 elevation or miR-145 repression promoted tumor growth. 33563550 circSLIT2 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues and cells Interaction( miR-510-5p/c-Myc/LDHA axis) CCK8//qRT-PCR//ChIP Here, our study found that the novel circRNA circSLIT2 was significantly upregulated in PDAC tissues and cells. Mechanistically, circSLIT2 acted as miRNA sponge to target miR-510-5p/c-Myc axis. Clinically, ectopic high-expression of circSLIT2 was correlated with unfavorable prognosis of PDAC patients. Yes Functional experiments demonstrated that circSLIT2 promoted the aerobic glycolysis and proliferation of PDAC cells in vitro, and circSLIT2 knockdown inhibited tumor growth in vivo. 34168116 hsa_circ_0005105 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues and cell lines Interaction(miR-20a-3p-COL11A1 axis) Wound Healing Assay//qRT-PCR//RIP//IHC//Invasion Assay We found that circ-0005105 expression was upregulated in both PDAC tissues and cell lines. Mechanistically, circ-000510 served as a competing endogenous RNA (ceRNA) of miR-20a-3p and indirectly modulated COL11A1 expression, leading to activation of epithelial-mesenchymal transition (EMT). Rescue experiments suggested that the oncogenic activity of circ-0005105 was dependent on the modulation of the miR-20a-3p-COL11A1 axis. Higher circ-0005105 expression correlated positively with the malignant clinical phenotype and poor prognosis of patients with PDAC. Yes Gain- and loss-of-function analysis showed that circ-0005105 facilitated both in vitro and in vivo cellular proliferation and invasion. 34183642 circEYA3 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues and cells Interaction(miR-1294/c-Myc axis) qRT-PCR//FISH CircEYA3 was elevated in PDAC tissues and cells, and a higher level of circEYA3 was significantly associated with a poorer prognosis in patients with PDAC.Mechanistically, circEYA3 functions as an endogenous miR-1294 sponge to elevate c-Myc expression, thus exerting its oncogenic functions. CircEYA3 was elevated in PDAC tissues and cells, and a higher level of circEYA3 was significantly associated with a poorer prognosis in patients with PDAC. Yes Functionally, circEYA3 increased energy production via ATP synthesis to promote PDAC progression in vitro and in vivo. 34419070 circNEIL3 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues and cell lines Interaction(miR-432-5p/ADAR1 axis ) qRT-PCR//RIP//Western Blot CircNEIL3 was upregulated in PDAC and promoted the progression of PDAC cells both in vitro and in vivo. Moreover, we discovered that the circNEIL3/miR-432-5p/ADAR1 axis was correlated with the PDAC clinical stage and overall survival of PDAC patients, while ADAR1 may reduce the biogenesis of circNEIL3. Moreover, we discovered that the circNEIL3/miR-432-5p/ADAR1 axis was correlated with the PDAC clinical stage and overall survival of PDAC patients, while ADAR1 may reduce the biogenesis of circNEIL3. Yes CircNEIL3 was upregulated in PDAC and promoted the progression of PDAC cells both in vitro and in vivo. 33750389 circRHOBTB3 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC cell lines and tissues Interaction(miR-600/NACC1) qRT-PCR//RNA Pull-Down//IHC circRHOBTB3 is highly expressed in PDAC cell lines and tissues, which also promotes PDAC autophagy and then progression in vitro and in vivo. Mechanistically, circRHOBTB3 directly binds to miR-600 and subsequently acts as a miRNA-sponge to maintain the expression level of miR-600-targeted gene NACC1, which facilitates the autophagy response of PDAC cells for adaptation of proliferation via Akt/mTOR pathway. Yes circRHOBTB3 is highly expressed in PDAC cell lines and tissues, which also promotes PDAC autophagy and then progression in vitro and in vivo. 34416910 circMYOF CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDA clinical specimens and cell lines Interaction(VEGFA/PI3K/AKT axis) qRT-PCR//RNA Pull-Down//Western Blot//Transwell Assay Real-time PCR indicated that it was highly expressed in PDA clinical specimens and cell lines. Gain-of- and loss-of-function assays showed that circMYOF induced progression in PDA. Mechanistically, RNA pull-down and luciferase reporter experiments elucidated that circMYOF, as a competing endogenous RNA for miR-4739, facilitated glycolysis via the VEGFA/PI3K/AKT pathway. Taken together, our findings indicate that circMYOF may work as a desirable biomarker and therapeutic target for PDA patients. Yes Gain-of- and loss-of-function assays showed that circMYOF induced progression in PDA. 34811346 circRTN4 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC patients Interaction(miR-497-5p-HOTTIP pathway) CCK8//qRT-PCR//Western Blot CircRTN4 was significantly upregulated in primary tumors from PDAC patients.The upregulated circRTN4 promotes tumor growth and liver metastasis in PDAC through the novel circRTN4-miR-497-5p-HOTTIP pathway. Also, circRTN4 stabilizes RAB11FIP1 to contribute EMT. Yes In vitro and in vivo functional studies revealed that circRTN4 promoted PDAC tumor growth and liver metastasis. 34983537 hsa_circ_0007367 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues and cells Interaction( miR-6820-3p/YAP1 axis ) CCK8//qRT-PCR//IHC We first identified that a novel circRNA, hsa_circ_0007367, was markedly upregulated in PDAC tissues and cells. Mechanistically, we confirmed that hsa_circ_0007367 could facilitate the expression of YAP1, a well-known oncogene, by sponging miR-6820-3p, which function as a tumor suppresser in PDAC cells. The results of ISH and IHC demonstrated that hsa_circ_0007367 and YAP1 were upregulated in PDAC tissues.In conclusion, our findings reveal that hsa_circ_0007367 acts as an oncogene via modulating miR-6820-3p/YAP1 axis to promote the progression of PDAC, and suggest that hsa_circ_0007367 may serve as a potential therapeutic target for treatment of PDAC. Furthermore, clinical data showed that higher hsa_circ_0007367 expression was correlated with advanced histological grade and lymph node metastasis in PDAC patients. Yes Functionally, in vivo and in vitro data indicated that hsa_circ_0007367 promotes the proliferation and metastasis of PDAC. 36008392 circUHRF1 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tumor tissues and cells Interaction(IRF3/circUHRF1/miR-1306-5p/ARL4C axis) CCK8//qRT-PCR//Western Blot Here, our results found that circUHRF1 was highly expressed in PDAC tumor tissues compared with normal tissues.Our findings suggest that circUHRF1 regulated ARL4C expression to promote PDAC progression through sponging miR-1306-5p. The role of miR-1306-5p in PDAC cellular progression has been elucidated, and the expression association between miR-1306-5p and circUHRF1 or ARL4C in PDAC tissues was analyzed. Furthermore, circUHRF1 expression in PDAC cells could be transcriptionally regulated by IRF3. Yes CircUHRF1 knockdown influenced PDAC cell proliferation, apoptosis, migration and EMT level in vitro, and tumor growth in vivo. 34983293 hsa_circ_0047744 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues and cell lines Interaction( miR-21/SOCS5 axis) ISH//qRT-PCR//FISH We found that circRNA_0047744 was weakly expressed in PDAC tissues and cell lines. Mechanistically, circ_0047744 could regulate SOCS5 expression by acting as a sponge of miR-21 to inhibit migration and invasion of PDAC cells. The expression of circ_0047744 was negatively correlated with lymph node metastasis and positively correlated with overall survival in PDAC patients. Yes Functionally, the overexpression of circ_0047744 suppressed cell migration and invasion in vitro and in vivo. 35334414 circCUL2 CircRNA Homo sapiens pancreatic ductal adenocarcinoma cancer-associated fibroblasts (CAFs) Interaction(miR-203a-3p/MyD88/NF-κB/IL6 axis) qRT-PCR//FISH We identified that circCUL2 was specifically expressed in cancer-associated fibroblasts (CAFs) but not in cancer cells. Mechanistically, circCUL2 functioned as a ceRNA and modulated the miR-203a-3p/MyD88/NF-κB/IL6 axis, thereby further activating the STAT3 signaling pathway in pancreatic cancer cells to induce PDAC progression. Moreover, the enrichment of circCUL2 in tumor tissues was significantly correlated with the poor prognosis of PDAC patients. Yes Upregulation of circCUL2 expression in normal fibroblasts (NFs) induced the iCAF phenotype, and then iCAFs promoted PDAC progression through IL6 secretion in vitro. Furthermore, circCUL2-transduced NFs promoted tumorigenesis and metastasis of PDAC cells in vivo, which was blocked by an anti-IL6 antibody. 35189958 hsa_circ_0006790 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC cells Interaction(CBX7/S100A11) Co-IP//qRT-PCR//RIP//FISH//ELISA//ChIP Exo enhanced circ_6790 expression in PDAC cells. In conclusion, our results suggest that MSC-derived exosomal circ_6790 could downregulate S100A11 in PDAC cells and hamper immune escape via CBX7-catalyzed DNA hypermethylation. Yes Knockdown of circ_6790 in Exo significantly attenuated the anti-tumor effect of Exo. 35693076 hsa_circ_8924 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissue interaction[miR-518d-5p/519-5p ] CCK8//qRT-PCR//Transwell Assay//Western Blot CircRNA8924 is highly expressed in CC tissue and can be considered a competitive endogenous RNA of the miR-518d-5p/519-5p family to promote the malignant biological behavior of CC cells. The study demonstrated that the expression level of circRNA8924 in CC was significantly higher than that in the adjacent normal tissues (P < 0.001), and that it was also associated with tumor size, FIGO staging and myometrial invasion. Yes The knockdown of circRNA8924 significantly inhibited the proliferation, migration and invasion of CC cells SiHa and HeLa. 30007986 hsa_circ_0023404 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Regulation[miR-136/TFCP2/YAP pathway] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay In the present study, we found that circRNA hsa_circ_0023404 was significantly upregulated in CC tissues compared to adjacent normal tissues.Taken together, our study for the first time demonstrated the pivot role of hsa_circ_0023404 and revealed a novel regulatory loop of hsa_circ_0023404/miR-136/TFCP2/YAP axis in CC progression. And its overexpression was correlated with poor prognosis in CC patients. Yes Functionally, we showed that knockdown of hsa_circ_0023404 significantly suppressed the proliferation, arrested the cell-cycle progression and inhibited cell migration and invasion in CC. 29738762 hsa_circ_0000285 CircRNA Homo sapiens Uterine Cervical Neoplasms "cell lines((HeLa, SiHa, C4-1,C-33a,NC104) C-33a))" Interaction[regulating FUS] CCK8//qRT-PCR//Cell Cycle Assay//Western Blot CircRNA_0000285 expression level was significantly higher in CC samples than that of corresponding normal tissues.CircRNA_0000285 could enhance the proliferation and metastasis of CC by up-regulating FUS, which might be a potential therapeutic target for CC treatment. Yes Moreover, the growth and migration abilities of CC cells were significantly inhibited after circRNA_0000285 was knocked down in vitro. 31696463 hsa_circ_0000515 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and the normal adjacent tissues,cell lines(H8,Hela, U14, SiHa, CaSki) Interaction[up-regulation of ELK1 ] Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay//Microarray//Transwell Assay We first found that hsa_circ_0000515 was highly expressed in the cervical cancer tissues and cells. Dual-luciferase reporter assay, RNA pull-down and RIP assays highlighted that hsa_circ_0000515 was able to act as a ceRNA of miR-326 to increase ELK1. Yes In vitro experiments exhibited that silencing of hsa_circ_0000515 or upregulation of miR-326 resulted in suppressed proliferation and invasion, along with induced apoptosis and autophagy of cervical cancer cells. 31772143 hsa_circ_0030235 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissue,cell lines Interaction[sponging miR-1253 and miR-1294] CCK8//qRT-PCR//Transwell Assay As a result, the data documented that circ_0030235 was upregulated in PDAC cell lines and cancerous tissues compared with HPDE and matched normal tissue specimens, respectively.Mechanistically, circ_0030235 directly sponges miR-1253 and miR-1294 in PDAC cells. What's more, the oncogenic properties of circ_0030235 was partly dependent on its suppression on miR-1253 and miR-1294. Overexpression of circ_0030235 in tumor samples is related to higher tumor stage and positive lymph node invasion. Additionally, analyses documented that high expression of circ_0030235 was associated with poor prognosis for PDAC patients. Yes Knockdown of circ_0030235 by siRNAs inhibited cell growth, migratory and invasive potential, and promoted cell apoptosis. On the contrary, overexpression of circ_0030235 caused the opposite effect. 30591218 circASH2L CircRNA Homo sapiens pancreatic ductal adenocarcinoma pancreatic ductal adenocarcinoma tissues Interaction[miR-34a,Notch 1] qRT-PCR//Transwell Assay//EdU Staining//Microarray We identified a circRNA (circ-ASH2L) based on our previous studies, detected its expression in different malignant cells and found that circ-ASH2L was highly expressed in pancreatic cells or tumor tissues and correlated with tumor malignancy.Further studies revealed that circ-ASH2L promoted tumor invasion, proliferation and angiogenesis by regulating miR-34a, thus regulate Notch 1 expression. Finally, we analyzed circ-ASH2L expression in clinical tissues and found that high circ-ASH2L expression was correlated with lymphatic invasion and TNM stage and was an independent risk factor for pancreatic patient survival. Yes "Moreover, Flow cytometry analysis showed that less cells stopped in G1 phase after overexpressing circ-ASH2L in Aspc-1 cells (Fig. ​(Fig.2i),2i), but silencing of circ-ASH2L arrested cell cycle in G1 phase in Capan-1 cells (Fig. ​(Fig.2j).2j). We further tested the effects of circ-ASH2L in angiogenesis. When HUVECs were transfected with circ-ASH2L, the tube-like structures were significantly enhanced compared to the normal or sh-circ-ASH2L groExpression[Expression[up-expression]-expression]s (Fig. ​(Fig.2k-l).2k-l). Together, the results above suggest that circ-ASH2L could promote invasion, proliferation and angiogenesis in PDAC. " 31718694 circRNF220 CircRNA Homo sapiens Leukemia, Myeloid, Acute AML cell lines Interaction(miR-330-5p/SOX4 ) qRT-PCR//MTT//RNA Pull-Down//Transwell Assay Expression detection identified that circRNF220 was overexpressed in AML.Target analysis indicated that circRNF220 directly targeted miR-330-5p, and the effects of si-circRNF220 were abrogated by miR-330-5p inhibitor. Moreover, circRNF220 targeted miR-330-5p to increase the expression of SOX4 and SOX4 promoted cell progression of AML. Yes In vitro experiments showed that silence of circRNF220 promoted cell apoptosis but impeded proliferation, cell cycle progression, invasion and glycolytic metabolism in AML cells. 35611720 circBCAR3 CircRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues and cells Interaction( miR-27a-3p/TNPO1) qRT-PCR//RIP CircBCAR3 was highly expressed in esophageal cancer tissues and cells and its expression was increased by hypoxia in vitro. Mechanistically, circBCAR3 can interact with miR-27a-3p by the competitive endogenous RNA mechanism to upregulate transportin-1 (TNPO1). Furthermore, our investigation indicated that splicing factor quaking (QKI) is a positive regulator of circBCAR3 via targeting the introns flanking the hsa_circ_0007624-formed exons in BCAR3 pre-mRNA. Hypoxia upregulates E2F7 to transcriptionally activate QKI. Yes Silencing of circBCAR3 repressed the proliferation, migration, invasion, and ferroptosis of esophageal cancer cells in vitro, as well as inhibited the growth and metastasis of esophageal xenograft in mice in vivo. The hypoxia-induced promotive effects on esophageal cancer cell migration and ferroptosis were rescued by circBCAR3 knockdown. 35840974 hsa_circ_0003602 CircRNA Homo sapiens Leukemia, Myeloid, Acute AML cell lines and tissues Interaction(miR-502-5p/IGF1R axis) qRT-PCR//RNA Pull-Down Hsa_circ_0003602 was upregulated and predicted poor survival in AML. Hsa_circ_0003602 sequestered miR-502-5p by functioning as a competitive endogenous RNA (ceRNA), thereby regulating IGF1R expression. Hsa_circ_0003602 acted as a tumor promoter in AML via miR-502-5p/IGF1R axis. Yes Knockdown of hsa_circ_0003602 in AML cell lines induced the inhibition of proliferation, migration, and invasion and caused apoptosis. 34988853 hsa_circ_0059707 CircRNA Homo sapiens Leukemia, Myeloid, Acute AML patients and cell line Interaction(miR-1287-5p) qRT-PCR//Bioinformatics Analysis In this study, we found that the expression levels of circ_0059707 were significantly decreased in AML patients with respect to normal controls (p < 0.001).Collectively, our research demonstrated that the down-regulation of circ_0059707 was highly evident in de novo AML patients. Our analysis also demonstrated that circ_0059707 inhibited cell growth and promoted apoptosis by up-regulating miR-1287-5p. Low expression levels of circ_0059707 were also associated with a poor prognosis. Yes Furthermore, circ_0059707 overexpression inhibited cell growth and promoted apoptosis in leukemia cells, compared with control cells. Circ_0059707- and empty plasmid-transfected cells were injected subcutaneously into BALB/c nude mice. We found that the tumor volume was significantly lower in mice in the circ_0059707 group than in control mice (p < 0.01). 36135094 hsa_circ_0044907 CircRNA Homo sapiens Leukemia, Myeloid, Acute AML patient-derived BM and AML cells Interaction(miR-186-5p/KIT) qRT-PCR//MTT Circ_0044907 was overexpressed in AML patient-derived BM and AML cells. Mechanically, circ_0044907 sponged miR-186-5p to block the inhibiting effect of miR-186-5p on KIT. Silenced miR-186-5p expression weakened circ_0044907 knockdown mediated suppression on AML cell viability, proliferation, and cycle progression. Also, forced KIT expression weakened miR-186-5p upregulation mediated inhibition on AML cell viability, proliferation, and cycle progression. Furthermore, circ_0044907 could distinguish AML patients from healthy controls, and high circ_0044907 expression in BM had a poor prognosis for AML patients, implying that circ_0044907 served as a diagnostic and prognostic indicator for AML. Yes Functionally, circ_0044907 silencing reduced cell viability, restrained cell proliferation, arrested cell cycle progression, and induced cell apoptosis in AML cells in vitro. Furthermore, circ_0044907 knockdown decreased AML cell growth in xenograft mouse models. 36004511 circNFIX CircRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow samples of AML patients, cell line Interaction(miR-876-3p/TRIM31 axis) qRT-PCR//RNA Pull-Down//Western Blot The expression level of circNFIX was significantly increased in the bone marrow samples of AML patients and AML cells when compared with normal controls. In addition, circNFIX indirectly regulated TRIM31 through miR-876-3p. Further, TRIM31 overexpression counteracted the effect of circNFIX silencing on AML cell proliferation and apoptosis. Yes CircNFIX silencing inhibited AML cell proliferation and promoted apoptosis. Inhibition of miR-876-3p reversed the effect of circNFIX knockdown on AML cell progression. 36094501 circRAD23B CircRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues Interaction[sponging miR-5095] qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay In the present study, we found that circular RNA-RAD23B (circRAD23B) was upregulated in specimens of patients with esophageal cancer. Next, we identified microRNA-5095 (miR-5095) as a target of circRAD23B, and found that miR-5095 was negatively correlated to the expression of circRAD23B in esophageal cancer. In addition, circRAD23B facilitated expression of PARP2 and AKT2 by sponging miR-5095, which might underlie the growth of esophageal cancer. Yes Further investigation revealed that circRAD23B promoted proliferation and invasion of esophageal cancer cells. 31208717 hsa_circ_0023397 CircRNA Homo sapiens Esophageal Neoplasms cell lines regulation[miR-106b] CCK8//qRT-PCR//Luciferase Report Assay//Flow Cytometry Compared with that in normal human esophageal epithelial cell line HET-1A, the expression of hsa_circ_RNA0023397 was down-regulated in three esophageal cancer cell lines in vitro.Hsa_circ_RNA0023397 is down-regulated in esophageal cancer cells and can act as miR-106b to affect the biological function of esophageal cancer cells. Yes Overexpression of hsa_circ_RNA0023397 overtly inhibited KYSE-150 cell proliferation and promoted its apoptosis. 32964974 hsa_circ_0008717 CircRNA Homo sapiens Esophageal Neoplasms EC cells regulation[miR-203/Slug] qRT-PCR//Luciferase Report Assay circRNA-0008717 expression was significantly upregulated in EC cells, and miR-2031 expression was decreased. The proliferation, invasion, and migration of EC cells were enhanced by circRNA-0008717 sponging the miR-203 to increase Slug expression. Yes Moreover, si-circRNA-0008717 or si-Slug inhibited the proliferation, migration, and invasion of EC cells. 32953799 circPRKCI CircRNA Homo sapiens Esophageal Neoplasms EC tissues and cells Expression[highly expressed] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay We observed that circPRKCI and PARP9 were upregulated while miR-186-5p was downregulated in EC tissues and cells. CircPRKCI regulated cell malignancy and radioresistance through modulating the miR-186-5p /PARP9 axis in EC, which provided a might target for EC treatment. Yes Furthermore, circPRKCI knockdown decreased tumor growth in vivo and constrained cell viability, colony formation, cell cycle progression, elevated cell radiosensitivity in EC cells in vitro. 32739469 hsa_circ_0003340 CircRNA Homo sapiens Esophageal Neoplasms esophageal cancer cells,tissues regulation[miR-564/TPX2 ] qRT-PCR//Western Blot Firstly, we found the expression levels of circ3340 are higher in ESCC and two esophageal cancer cells than in adjacent normal tissues and Het-1a cells. Downregulation of circ3340 had a negative influence on EC1 and EC9706 cells by affecting the miR-564/TPX2 pathway. Yes Moreover, knockdown of circ3340 or enhancement of miR-564 expression had similar effects in EC1 and EC9706 cells, i.e., inducing cell apoptosis, inhibiting cell proliferation, and arresting cell invasion. 32535036 hsa_circ_0006168 CircRNA Homo sapiens Esophageal Neoplasms EC tumors and cells regulation[miR-384/RBBP7 axis via activation of S6K/S6 pathway] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Circ_0006168 and RBBP7 were over-expressed while miR-384 was low-expressed in EC tumors and cells.Abundance of circ_0006168 contributes to cell proliferation, migration, invasion, and glycolysis in EC by competitively sponging miR-384 to facilitate RBBP7 expression, representing prospective targets for EC therapy. Yes The repression of circ_0006168 attenuated cell proliferation, migration, invasion, and glycolysis in EC. 31957828 circAGFG1 CircRNA Homo sapiens Esophageal Neoplasms ESCC cell lines Interaction(miR-4306 ) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay CircAGFG1 was observably upregulated in ESCC cell lines. Mechanistic analysis evidenced that circAGFG1 might act as a competitive endogenous RNA of miR-4306 to relieve the repressive effect of miR-4306 on its target MAPRE2. Yes Besides, circAGFG1 silencing hindered ESCC cell development in vitro, and these effects were enhanced by miR-4306 overexpression or MAPRE2 silencing. 34461454 circVIM CircRNA Homo sapiens Esophageal Neoplasms EC tissues or cells Interaction(miR-124/PD-L1 axis) qRT-PCR//Western Blot Significant upregulation of circ-VIM and PD-L1 and downregulation of miR-124 were detected in EC tissues or cells. Circ-VIM sponged miR-124 and released its suppression on the downstream target PD-L1. Yes By modulating miR-124/PD-L1 axis, silencing circ-VIM and applying sevoflurane both inhibited immune escape and multiple oncogenic activities of EC in vitro, and suppressed xenograft growth and lung metastases in vivo. The inactivation of Ras/ERK signaling pathway was involved in suppression of malignant phenotypes by silencing circ-VIM and sevoflurane treatment. 34018092 hsa_circ_0000554 CircRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues Interaction(miR-485-5p/FERMT1) qRT-PCR//Western Blot Circ_0000554 and FERMT1 expression was enhanced in esophageal cancer tissues and radioresistant esophageal cancer tissues. Importantly, circ_0000554 served as a sponge for miR-485-5p in esophageal cancer cells. And FERMT1 acted as a downstream target for miR-485-5p. Additionally, circ_0000554 modulated FERMT1 expression via miR-485-5p. Yes Both circ_0000554 and FERMT1 repression blocked cell colony formation, migration, invasion and elevated cell radiosensitivity and apoptosis in esophageal cancer cells. 33470617 hsa_circ_0004370 CircRNA Homo sapiens Esophageal Neoplasms EC tissues and cells Interaction(miR-1301-3p/COL1A1 axis) qRT-PCR//RNA Pull-Down We discovered that circ_0004370 was remarkably upregulated in EC tissues and cells.Moreover, we explored its regulatory mechanism and found that circ_0004370 directly bound to miR-1301-3p and COL1A1 was verified as a target of miR-1301-3p. Yes Knockdown of circ_0004370 inhibited cell proliferation, migration as well as invasion, and promoted apoptosis in vitro, while its effect was rescued by miR-1301-3p inhibition. And circ_0004370 mediated the EMT process in EC cells. 33506107 circSFMBT2 CircRNA Homo sapiens Esophageal Neoplasms EC samples and cells Interaction(miR-107/SLC1A5 axis) qRT-PCR//RNA Pull-Down//Transwell Assay Circ-SFMBT2 was overexpressed in EC samples and cells. Circ-SFMBT2 targeted miR-107 and the regulation of circ-SFMBT2 was achieved by sponging miR-107. SLC1A5 was a target of miR-107, and it worked as an oncogene in EC cells. Yes . Circ-SFMBT2 downregulation inhibited EC cell proliferation, invasion and glutamine metabolism. 34530825 hsa_circ_0086414 CircRNA Homo sapiens Esophageal Neoplasms EC tissues and cells Interaction(miR-1290/SPARCL1 pathway) qRT-PCR//Luciferase Report Assay Results showed that circ_0086414 and SPARCL1 expression were significantly downregulated, while miR-1290 was upregulated in EC tissues and cells. Besides, circ_0086414 acted as a miR-1290 sponge and regulated EC cell processes by binding to the miRNA. MiR-1290 also participated in EC malignant progression through SPARCL1. EC patients with low circ_0086414 expression had a poor prognosis. Yes Increasing circ_0086414 expression led to decreased EC cell proliferation, invasion and glycolysis and increased cell apoptosis, accompanied by a decrease of N-cadherin expression and an increase of E-cadherin expression. Also, the enforced expression of circ_0086414 delayed tumor tumorigenesis. 35549806 hsa_circ_0058063 CircRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues Interaction(miR-377-3p/HOXA1 axis) Flow Cytometry//qRT-PCR//Wound Healing Assay Circ_0058063 and HOXA1 were upregulated, while miR-377 was downregulated in esophageal cancer. Circ_0058063 targeted miR-377-3p, and HOX4 was a target of miR-377-3p. Yes Knockdown of circ_0058063 inhibited migration, invasion and proliferation and promoted apoptosis of esophageal cancer cells. MiR-377-3p inhibition or HOXA1 overexpression could restore the effect of si-circ_0058063 on esophageal cancer cells. Knockdown of circ_0058063 repressed the growth of esophageal cancer tumors in vivo. 36729977 hsa_circ_0001273 CircRNA Homo sapiens Esophageal Neoplasms EC tumor tissues and cells Interaction(miR-622/SLC1A5 signaling axis) Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Colony Formation Assay Circ_0001273 was upregulated in EC tumor tissues and cells.MiR-622 was targeted by circ_0001273, and its inhibition reversed the functional effects of circ_0001273 knockdown. SLC1A5 was a target gene of miR-622, and circ_0001273 targeted miR-622 to positively regulate SLC1A5 expression. The inhibitory effects of miR-622 enrichment on EC cell proliferation, migration, EMT and glutamine metabolism were recovered by SLC1A5 overexpression. Yes Knockdown of circ_0001273 repressed EC cell proliferation, migration, epithelial-mesenchymal transition (EMT) and glutamine metabolism. Circ_0001273 knockdown also blocked tumor development in animal models. 35567340 circPOLR1C CircRNA Homo sapiens Esophageal Neoplasms EC cell and tissues Interaction(miR-361-3p ) qRT-PCR//Transwell Assay//FISH Highly expressed circPOLR1C in EC was related to tumor differentiation and invasion. The enrichment of miR-361-3p was higher than that of other targeted miRNAs. circPOLR1C adsorbed miR-361-3p to regulate apoptosis- and EMT-related genes and partially reversed the tumor suppressive effect of miR-361-3p, which was lowly expressed in EC tissues. Silencing the target genes of miR-361-3p also inhibited the malignant development of EC cells. Highly expressed circPOLR1C in EC was related to tumor differentiation and invasion. Yes circPOLR1C silencing inhibited circPOLR1C expression and EC cell malignant function, while circPOLR1C overexpression promoted the growth of transplanted tumors and lung metastasis. 36590309 hsa_circ_0001060 CircRNA Homo sapiens Osteosarcoma OS tumor tissues Interaction(miR-203a-5p-TRIM21 or miR-208b-5p-MAP3K5 or miR-203a-5p-PRKX) qRT-PCR//Wound Healing Assay//Colony Formation Assay We previously found that circ_0001060 was highly expressed in OS tumor tissues. Using bioinformatics analysis, we built three circRNA-miRNA-mRNA regulatory modules (circ_0001060-miR-203a-5p-TRIM21, circ_0001060-miR-208b-5p-MAP3K5, and circ_0001060-miR-203a-5p-PRKX), suggesting that these signaling axes may be involved in the inhibitory effect of circ_0001060 on OS. In this work, we identified that high level expression of circ_0001060 was significantly associated with late clinical stage, larger tumor volume, higher frequency of metastasis, and poor prognosis in OS patients. Yes Furthermore, we confirmed that silencing circ_0001060 inhibited the proliferation and migration of OS cell. 36580535 circDOCK1 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction( miR-936/LEF1 axis) qRT-PCR//RIP Increased circDOCK1 and LEF1, and decreased miR-936 were found in OS tissues and cell lines. Bioinformatics analysis exhibited that circDOCK1 acted as a sponge for miR-936 and LEF1 was a downstream target of miR-936. Moreover, circDOCK1 functions through modulation of the miR-936/LEF1 axis. Yes Furthermore, circDOCK1 silencing might suppress OS cell proliferation, migration, invasion, and angiogenesis in vitro. 36147545 hsa_circ_0078767 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells Interaction(miR-330-3p/CDK14 ) qRT-PCR//IHC//H&E Staining Aberrant abundance of circ_0078767 was found in both osteosarcoma tissues and cells, relating to dismal prognosis in patients with osteosarcoma. Additionally, miR-330-3p targeted and decreased CDK14 expression whereby motivating the malignant phenotypes of osteosarcoma cells. Through in vivo experiments, we further confirmed that circ_0078767 targeted miR-330-3p to upregulate CDK14, whereby strengthening the in vivo tumorigenic and metastatic ability of osteosarcoma cells. Aberrant abundance of circ_0078767 was found in both osteosarcoma tissues and cells, relating to dismal prognosis in patients with osteosarcoma. Yes Functionally, circ0078767 strengthened the proliferation, invasiveness, and migration of osteosarcoma cells, which could be neutralized by miR-330-3p. 35307379 hsa_circ_0000282 CircRNA Homo sapiens Osteosarcoma OSA tissues and cell lines regulation[miR-192/XIAP axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//BrdU Circ_0000282 was highly expressed in OSA tissues and cell lines, which represented positive correlation with Enneking stage of OSA patients and negative correlation with tumor differentiation degree. Circ_0000282 was a novel oncogenic circRNA in OSA. Circ_0000282/miR-192/XIAP axis regulated OSA cell proliferation apoptosis with competitive endogenous RNA mechanism. Circ_0000282 was highly expressed in OSA tissues and cell lines, which represented positive correlation with Enneking stage of OSA patients and negative correlation with tumor differentiation degree. Yes In vitro experiments confirmed that overexpression of circ_0000282 markedly facilitated OSA cell proliferation and repressed cancer cell apoptosis in comparison to control group. Besides, knockdown of circ_0000282 repressed OSA cell proliferation and promoted apoptosis. 33097010 hsa_circ_0086996 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissue interaction[miR-125b-5p] Northern Blot//Western Blot//Flow Cytometry//qRT-PCR//RIP//FISH//Luciferase Report Assay Hsa_circ_0086996 (Circ_0086996) was found to upregulated in tumor tissue compared to adjacent tissue.Our study discovers that Circ_0086996 acts as miR-125b-5p sponge to mediate the tumorigenicity, which could act as a potential biomarker for the osteosarcoma and provides a novel insight for the mechanism in osteosarcoma. Circ_0086996 knockdown also induced cell cycle arrest in G0/G1 phaseand promoted cell apoptosis in SAOS2 and MG-63 cells. Yes Circ_0086996 knockdown significantly suppressed cell proliferation, migration, and invasion. 33053498 hsa_circ_0028171 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines regulation[circ_0028171/miR-218-5p/IKBKB axis] RNA Pull-Down//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We found that circ_0028171 displayed a remarkably higher expression in both OS tissues and cell lines. our research reveals that circ_0028171 might promote the malignant behavior of OS tissues through miR-218-5p/IKBKB axis, which could be a potential novel marker for early diagnosis of OS. Yes Knockdown of circ_0028171 suppressed OS tumor growth in vitro and in vivo, while up-regulated circ_0028171 remarkably enhanced cell proliferation, migration and invasion abilities in OS. 33041665 hsa_circ_0001721 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells regulation[miR-372-3p/MAPK7 Axis] Flow Cytometry//qRT-PCR//RIP//MTT//Transwell Assay The levels of circ_0001721 and MAPK7 were upregulated in osteosarcoma tissues and cells, while miR-372-3p was downregulated.Circ_0001721 promoted osteosarcoma development through the miR-372-3p/MAPK7 axis. Yes Knockdown of circ_0001721 inhibited glycolysis, cell proliferation, cell migration, invasion and epithelial-to-mesenchymal transition (EMT), and promoted apoptosis. 32982424 circITGA7 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines regulation[miR-370/PIM1 Axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that circITGA7 was upregulated in OS tissues and cell lines.In summary, this study shows that circITGA7 promotes OS proliferation and metastasis via miR-370/PIM1. Yes Knockdown of circITGA7 weakened the cell's ability to proliferate and metastasize. 32963582 hsa_circ_0001649 CircRNA Homo sapiens Osteosarcoma OS tissues and cells interaction[miR-338-5p, miR-647 and miR-942] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Circ_0001649 was low-expressed in OS tissues and cell lines.Circ_0001649 suppressed OS cell proliferation and STAT pathway and induced apoptosis through sponging miR-338-5p, miR-647 and miR-942. Yes Circ_0001649 overexpression suppressed U2OS and HOS cell viability and survival fraction, and induced apoptosis presented as the increasing levels of Apaf-1, cleaved-caspase-3 and cleaved-caspase-9. 32954926 circXPR1 CircRNA Homo sapiens Osteosarcoma OS tissue regulation[miR-214-5p/DDX5 axis] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay We identified one upregulated circRNA (Circ-XPR1), and RT-PCR was performed to further confirm the expression abundance in OS tissue. Therefore, the Circ-XPR1/miR-214-5p/DDX5 axis may serve as a potential therapeutically relevant target for OS. Yes Knockdown of Circ-XPR1 significantly reduced the proliferation of OS cells. Gain- and loss-of-function studies showed that Circ-XPR1 promoted OS cell proliferation by sponging miR-214-5p to regulate DDX5 expression. 32920730 circSIPA1L1 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines regulation[miR-379-5p/MAP3K9 Axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Circ_SIPA1L1 abundance was aberrantly elevated in OS tissues and cell lines. Circ_SIPA1L1 promoted the progression of OS via miR-379-5p/MAP3K9 axis. Yes Circ_SIPA1L1 accelerated the proliferation and metastasis abilities of OS cells. 32897735 circCCDC66 CircRNA Homo sapiens Osteosarcoma OS tissue samples and OS cell lines regulation[circCCDC66/miR-338-3p/PTP1B axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay High circCCDC66 expression level was found in OS patient-derived tissue samples and OS cell lines by qRT-PCR.. Collectively, our findings demonstrated that circCCDC66 contributed to malignant behaviors of OS cells by miR-338-3p/PTP1B pathway, which suggested circCCDC66/miR-338-3p/PTP1B axis might be a potential therapeutic target. Yes Through functional experiments, we found that circCCDC66 knockdown promoted the inhibition of cell proliferation and metastatic of OS cell lines. 32851074 hsa_circ_0010220 CircRNA Homo sapiens Osteosarcoma osteosarcoma cells regulation[miR-503-5p/CDCA4 axis] Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Invasion Assay//Transwell Assay Circ_0010220 expression was markedly increased in osteosarcoma cells. In conclusion, we indicated circ_0010220 can be an important biomarker for osteosarcoma via regulating miR-503-5p and CDCA4. Yes Additionally, knockdown of circ_0010220 significantly depressed tumor growth. CCK-8 analysis indicated that down-regulation of circ_0010220 inhibited osteosarcoma cells proliferation. Flow cytometry assay showed that knockdown of circ_0010220 induced cell apoptosis and blocked cell cycle in the G1 phase. 32827680 hsa_circ_0008934 CircRNA Homo sapiens Osteosarcoma cell line regulation[sponging miR-145-5p to enhance E2F3 expression] qRT-PCR//Tunel//Western Blot Hsa_circ_0008934 expression was significantly elevated in SaOS2 and MG63 cells. Elevated hsa_circ_0008934 expression promotes the proliferation and migration of osteosarcoma cells by sponging miR-145-5p to enhance E2F3 expression. Yes Hsa_circ_0008934 silencing significantly reduced proliferation, enhanced apoptosis, blocked cell cycle progression, and impaired migration and invasion capacities of SaOS2 cells. Opposite cellular alterations were achieved by overexpressing hsa_circ_0008934 in MG63 cells. 32822848 hsa_circ_0008035 CircRNA Homo sapiens Osteosarcoma OSA tissues and cells,serum regulation[upregulating microRNA-375] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Our results demonstrated that hsa_circ_0008035 was overexpressed in serum of OSA patients, OSA tissues and cells. In conclusion, silencing hsa_circRNA_0008035 exerted repressive function on OSA cell growth and migration and Notch pathway by accelerating miR-375. Yes Silencing hsa_circRNA_0008035 impeded OSA cell growth and migration, while hsa_circ_0008035 facilitated cell behaviors of hFOB1.19 cells. 32779548 circHIPK3 CircRNA Homo sapiens Osteosarcoma OS cell lines regulation[miR-637/STAT3 Axis ] qRT-PCR In this study, we performed experiments with the human OS cell lines and the results showed that the expression of circHIPK3 in OS cell lines was significantly upregulated compared to that in the normal cell line. In conclusion, our research uncovered an important role of the circHIPK3/miR-637/STAT3 pathway in the migration and invasion of OS cells and suggested that circHIPK3 may be a prognostic marker and a promising therapeutic target for OS. Yes In addition, the results showed that circHIPK3 could promote the migration, invasion, and growth of OS cells. 32775413 circFAT1(e2) CircRNA Homo sapiens Osteosarcoma OS tissues regulation[circFAT1(e2)/miR-181b/HK2 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In the present study, we identified a circRNA circFAT1(e2) with an upregulated expression level in OS tissues. On the whole, our study indicated that circFAT1(e2) exerted oncogenic roles in OS and suggested the circFAT1(e2)/miR-181b/HK2 axis might be a potential therapeutic target. Yes By functional experiments, we found that circFAT1(e2) depletion significantly suppressed the proliferation and reduced migration in OS. 32733938 circCNST CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines interaction[Sponging miR-421] qRT-PCR//MTT//RIP//FISH As a result, we found that the expression levels of circCNST were dramatically increased in OS tissues and cell lines as compared with the adjacent normal tissues, and it was associated with tumor size and poor survival in OS patients. In conclusion, our findings demonstrate that circCNST promotes the tumorigenesis of OS cells by sponging miR-421, and provides a potential biomarker for patients with OS. As a result, we found that the expression levels of circCNST were dramatically increased in OS tissues and cell lines as compared with the adjacent normal tissues, and it was associated with tumor size and poor survival in OS patients. Yes Knockdown of circCNST repressed cell viability, colony formation, and xenograft tumor growth, while restored expression of circCNST reversed these effects. 32693639 hsa_circ_0005909 CircRNA Homo sapiens Osteosarcoma OS tissues and cells regulation[miR-936/HMGB1 axis] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Circ_0005909 level was upregulated in OS tissues and cells. Circ_0005909 inhibition impeded the progression of OS via downregulating HMGB1 via sponging miR-936. Yes OS patients with high circ_0005909 expression had a lower survival rate. Circ_0005909 inhibition reduced tumor growth in vivo and constrained cell viability, colony formation, migration, invasion, and EMT of OS cells in vitro. 32684842 hsa_circ_100284 CircRNA Homo sapiens Osteosarcoma OS tissues regulation[downregulating PTEN and EMP1] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Circ100284 had a high level in OS tissues. Circ100284 promotes the progression of OS cells by downregulating PTEN and EMP1. The high expression of circ100284 was positively correlated with tumor size, pathological stage, and lung metastasis, and negatively correlated with patient survival time. Yes Knocking down circ100284 in OS cells damaged the cell viability and invasiveness, blocked cell cycle, and promoted cell apoptosis. 32633341 circEIF4G2 CircRNA Homo sapiens Osteosarcoma OS tissues and cells interaction[Sponging miR-218] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The present study identified that a novel circRNA circEIF4G2 was upregulated in OS tissues and cells. Mechanically, we found that circEIF4G2 could directly bind to miR-218, and miR-218 mediated the effect of circEIF4G2 knockdown on OS progression. Yes Loss-of-function assays showed that circEIF4G2 knockdown significantly suppressed OS cell proliferation, migration, and invasion. 32596384 hsa_circ_0003732 CircRNA Homo sapiens Osteosarcoma OS tissues regulation[miR-545/CCNA2 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//EdU Staining In the present study, we showed that hsa_circ_0003732 was up-regulated in OS tissues and elevated level of hsa_circ_0003732 was linked to poor prognosis of OS patients.Altogether, our findings demonstrate that hsa_circ_0003732 promotes OS cells proliferation via miR-545/CCNA2 axis and imply hsa_circ_0003732 may be a potential prognosis biomarker and therapeutic target for OS. In the present study, we showed that hsa_circ_0003732 was up-regulated in OS tissues and elevated level of hsa_circ_0003732 was linked to poor prognosis of OS patients. Yes Functional investigation indicated that hsa_circ_0003732 promoted proliferation of OS cells. 32537647 circUBAP2 CircRNA Homo sapiens Osteosarcoma OS tissues and cells regulation[miR-641/YAP1 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The level of circUBAP2 was significantly upregulated in OS tissues and cells compared with normal tissues and cells, which was contrary to the expression of miR-641.Knockdown of circUBAP2 impeded proliferation and invasion of OS cells by downregulating the expression of YAP1 via sponging miR-641. Yes Downregulation of circUBAP2 suppressed proliferation and invasion of OS cells and weakened the process of epithelial-mesenchymal transition (EMT). 32528231 circXPO1 CircRNA Homo sapiens Osteosarcoma OC tissues regulation[regulate XPO1 expression] qRT-PCR//Microarray Elevation of circ-XPO1 and XPO1 mRNA was identified in OS tissue specimens and cells by qRT-PCR.Taken together, we found that circ-XPO1 regulated the expression of XPO1 through sponging miRNAs as a competing endogenous (ceRNA), providing the possibility that circ-XPO1 might play as a new therapeutic target for OS. In addition, enhanced expression of circ-XPO1 and XPO1 mRNA both correlated with poor prognosis for the patients with OS, as estimated by Kaplan-Meier analysis. Yes Functionally, circ-XPO1 and XPO1 both facilitated the growth and invasion and decreased the apoptosis of OS cells. 33091396 circECE1 CircRNA Homo sapiens Osteosarcoma OS tissues and cells regulation[c-Myc/TXNIP axis] qRT-PCR//IHC//Western Blot We found that CircECE1 is highly expressed in OS tissues and cells and that CircECE1 knockdown suppresses tumor proliferation and metastasis both in vitro and in vivo. CircECE1 regulates the Warburg effect through the c-Myc/TXNIP axis. Yes We found that CircECE1 is highly expressed in OS tissues and cells and that CircECE1 knockdown suppresses tumor proliferation and metastasis both in vitro and in vivo. 33106166 circMGEA5 CircRNA Homo sapiens Osteosarcoma OS tissues Interaction(miR-153-3p and miR-8084) qRT-PCR//ChIP CircMGEA5 was significantly upregulated in metastatic OS tissues compared to primary tissues. Mechanistically, circMGEA5 acted as a competing endogenous RNA (ceRNA) to directly sponge miR-153-3p and miR-8084, resulting in increasing ZEB1 and Snail expression, respectively, thereby inducing EMT and metastasis. In turn, ZEB1 and Snail were capable to bind to circMGEA5 promoter, activating circMGEA5 transcription, thus forming a positive feedback loop. High circMGEA5 was positively related with shorter overall and disease-free survival time. Yes Knockdown of circMGEA5 suppressed OS cell migration, invasion, and epithelial-mesenchymal transition (EMT). 36564929 circCRIM1 CircRNA Homo sapiens Osteosarcoma OS tissues and cells regulation[miR-432-5p/HDAC4 axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay In OS tissues and cells, circCRIM1 was differentially up-regulated. Our findings elucidated the oncogenic function of circCRIM1 in OS via the regulation of the miR-432-5p/HDAC4 axis, affording a novel view about how circRNA participated in OS development. Yes Functionally, cell proliferation, migration and invasion were suppressed while autophagy was promoted after circCRIM1 was down-regulated in OS cells. 33116874 hsa_circ_0000264 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues and cells Interaction(hsa-let-7b-5p/HMGA2 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay hsa_circ_0000264 was upregulated in HNSCC tissues and cells, and its loop structure was confirmed. Mechanistically, hsa_circ_000026 upregulation can upregulate the expression of high mobility group AT-hook 2 (HMGA2) by sponging hsa-let-7b-5p, which in turn promotes HNSCC progression. Yes Knockdown of hsa_circ_0000264 inhibited the migration, invasion, and epithelial-to-mesenchymal transition of HNSCC cells in vivo and in vitro. 36214613 circFAT1 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines interaction[ miR-375] qRT-PCR//FISH//Western Blot In this study, we observed significant upregulation of circFAT1 originating from exon 2 of the FAT1 gene in human osteosarcoma tissues and cell lines.Mechanistic studies revealed that circFAT1 contains a binding site for the microRNA-375 (miR-375) and can abundantly sponge miR-375 to upregulate the expression of Yes-associated protein 1. Yes Inhibition of circFAT1 effectively prevented the migration, invasion, and tumorigenesis of osteosarcoma cells in vitro and repressed osteosarcoma growth in vivo. 30514309 hsa_circ_0002052 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines Regulation[miR-1205/APC2 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In the present study, we identified a novel circRNA hsa_circ_0002052 significantly downregulated in osteosarcoma (OS) tissues and cell lines. Our study suggested hsa_circ_0002052/miR-1205/APC2/Wnt/β-catenin axis might be a potential target for OS therapy. Yes Functionally, we showed that hsa_circ_0002052 overexpression significantly suppressed OS cell proliferation, migration and invasion while promoting apoptosis in vitro. 29852168 circMMP9 CircRNA Homo sapiens Osteosarcoma Osteosarcoma tissues Regulation[miR-1265/CHI3L1 Axis] CCK8//qRT-PCR//Transwell Assay circMMP9 was overexpressed in cancer tissues. Yes Overexpressed circMMP9 was correlated with advanced tumor stage and predicted poor prognosis. circMMP9 knockExpression[down-expression] exhibited a tumor-sExpression[Expression[up-expression]-expression]pressive phenotype via sExpression[Expression[up-expression]-expression]pressing proliferation, migration and invasion. 31754311 hsa_circ_0001785 CircRNA Homo sapiens Osteosarcoma cell lines Interaction[sponging miR-1200 to Expression[highly expressed]regulate HOXB2] qRT-PCR//Luciferase Report Assay//EdU Staining//Western Blot Consistent with the microarray analysis, circ-0001785 was highly expressed in osteosarcoma cell lines. Furthermore, we confirmed that circ-0001785 competitively bound to miR-1200, thus Expression[Expression[up-expression]-expression]-regulating its target gene HOXB2. Western blot analyses revealed that circ-0001785 regulated the PI3K/Akt signaling and Bcl-2 family pathway in osteosarcoma. Yes KnockExpression[down-expression] of circ-0001785 attenuated proliferative ability, but induced the apoptosis of osteosarcoma cells. 31116090 hsa_circ_0102049 CircRNA Homo sapiens Osteosarcoma OS tissues Interaction[sponging miR-1304-5p] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Circ_0102049 was overexpressed in both OS specimens and cells. Moreover, the level of circ_0102049 in OS patients was markedly correlated with larger tumor size, pulmonary metastasis and poor prognosis Yes Circ_0102049 remarkably accelerated cell proliferation, migration and invasion but attenuated cell apoptosis in OS cells analyzed by gain/loss of function experiments. 31727503 hsa_circ_0000502 CircRNA Homo sapiens Osteosarcoma OS tissue,cell lines Interaction[sponging miR-1238] CCK8//qRT-PCR//Transwell Assay Circ_0000502 was identified upregulated in both OS tissue specimens and cells. For mechanism exploration, circ_0000502 could directly sponge microRNA (miR)-1238, and the oncogenic functions of circ_0000502 is partially dependent on its regulation of miR-1238 proved by rescue assays. In summary, this study might help to develop rational predictive and therapeutic target for patients with OS. In addition, its expression predicts clinical severity and unfavorable prognosis in the 63 recruited patients with OS. Yes Circ_0000502 facilitated cell proliferation, migration, and invasion in OS cells and inhibited cell apoptosis. The animal study further confirmed the in vitro results. 30525215 circORC2 CircRNA Homo sapiens Osteosarcoma cell lines Interaction[miR-19a] RNA Pull-Down//Western Blot//RIP//qRT-PCR//Luciferase Report Assay//Transwell Assay This research showed that circ_ORC2 was generally up-regulated in various osteosarcoma cell lines, and mainly distributed in the cytoplasm.Circ_ORC2 had the binding site of miR-19a, and its expression was positively correlated with miR-19a expression. RIP experiments showed that circ_ORC2 could bind to Ago2 protein. RNA pull-down using biotinylated circ_ORC2 or miR-19a showed that circ_ORC2 could directly interact with miR-19a, and dual luciferase reporter gene assay also confirmed that miR-19a could bind to circ_ORC2. After circ_ORC2 knockdown, miR-19a expression was down-regulated, but the downstream target gene PTEN expression was up-regulated, and the phosphorylation level of Akt was reduced, which indicated that circ_ORC2 enhanced the inhibition of miR-19a on PTEN expression by combining miR-19a. When co-transfected with circ_ORC2 siRNA and miR-19a mimics or PTEN siRNA, the above cell biological behaviors did not change significantly. Therefore, circ_ORC2 binds with miR-19a and enhances its expression, thereby inhibiting downstream PTEN expression and activating Akt pathway to promote osteosarcoma cell growth and invasion. Yes Further functional experiments showed that after circ_ORC2 knockdown, cell proliferation and invasion decreased, while the apoptosis level increased. 31103262 hsa_circ_0001721 CircRNA Homo sapiens Osteosarcoma OS tissue,cell lines Interaction[sponging miR-569 and miR-599] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay We found that circ_0001721 was enhanced in OS tissue samples and cell lines and the overexpression of circ_0001721 is closely related to clinical severity. Yes What's more, loss-of-function and gain-of-function assays demonstrated circ_0001721 facilitates cell progression in OS. 30396080 circSAMD4A CircRNA Homo sapiens Osteosarcoma OS tissues Interaction[ circSAMD4A/miR-1244/MDM2] CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Then, we identified a novel circRNA(circ_101356/circ_0004846, we named circSAMD4 in the present study) and found it was highly expressed in the OS tissues compared to adjacent non-cancerous tissues.In mechanism, circSAMD4A could sponge miR-1244 in OS cells. Moreover, we verified that MDM2 was a target of miR-1244. In conclusion, circSAMD4A/miR-1244/MDM2 regulatory loop might be a promising therapeutic target for OS treatment. Yes Furthermore, we indicated that circSAMD4A promoted OS proliferation in vivo and in vitro. 31200957 circANKIB1 CircRNA Homo sapiens Osteosarcoma cell lines Interaction[SOCS3/STAT3 pathway] RIP//Luciferase Report Assay//RNA Pull-Down Further studies have shown that circ_ANKIB1 has binding sites for miR-19b, and both molecules were generally upregulated in osteosarcoma cells.Circ_ANKIB1 promoted miR-19b expression, inhibited the expression of the downstream target gene SOCS3, and then activated the STAT3 pathway. When cotransfected with circ_ANKIB1 siRNA, and miR-19b mimics, the expression of SOCS3 and the phosphorylation level of STAT3 did not change significantly.When cotransfected with circ_ANKIB1 siRNA and miR-19b mimics or SOCS3 siRNA, the cell proliferation, apoptosis, and invasion levels did not change significantly, suggesting that circ_ANKIB1 could affect the STAT3 pathway and osteosarcoma cell growth and invasion by enhancing the regulation of miR-19b on the downstream target gene SOCS3. Yes Continuous detection of cell growth and invasion showed that the downregulation of circ_ANKIB1 or miR-19b significantly inhibited cell proliferation and invasion, but increased the apoptotic level. 31667786 circLRP6 CircRNA Homo sapiens Osteosarcoma OS tissues Interaction[regulating KLF2 and APC levels ] Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Invasion Assay//ChIP CircLRP6 level markedly increased in OS tissues. Collectively, circLRP6 was highly expressed in OS and served as an oncogene by binding to LSD1 and EZH2 to inhibit expressions of KLF2 and APC. Besides, OS patients with high expression of circLRP6 showed shorter disease-free survival and over-all survival than those with low expression. Yes CircLRP6 knockdown suppressed proliferative, migratory and invasive rates of OS cells. 31396323 circMYO10 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues, cell lines Regulation[miR-370-3p/RUVBL1 axis] RNA Pull-Down//Western Blot//qRT-PCR//FISH//Luciferase Report Assay//IP CircMYO10 was significantly upregulated, while miR-370-3p was downregulated, in osteosarcoma cell lines and human osteosarcoma samples. CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to promote chromatin remodeling and thus enhances the transcriptional activity of β-catenin/LEF1 complex, which indicates that circMYO10 may be a potential therapeutic target for osteosarcoma treatment. Yes Silencing circMYO10 inhibited cell proliferation and EMT in vivo and in vitro. 31665067 hsa_circ_0003998 CircRNA Homo sapiens Osteosarcoma steosarcoma tissue and cell lines Interaction[binding to miR-197-3p ] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Compared to normal control tissues and cells, the expression of circ-0003998 was significantly up-regulated in both osteosarcoma tissue samples and cell lines.Meanwhile, circ-0003998 up-regulates the expression of KLF10 by binding to miR-197-3p, thereby promoting osteosarcoma cell growth and invasion, and accelerating the progression of osteosarcoma. Highly-expressed circ-0003998 was significantly associated with poor overall survival of patients with osteosarcoma. Yes In vitro experiments revealed that the down-regulation of circ-0003998 significantly inhibited the proliferative ability and invasiveness of osteosarcoma cells. 31858530 circCAMSAP1 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines interaction[miR-145-5p,FLI1 ] RNA Pull-Down//Western Blot//ISH//Wound Healing Assay//Colony Formation Assay//CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//IHC//Transwell Assay We found that circCAMSAP1, also named hsa_circ_0004338, is significantly upregulated in human osteosarcoma tissues and cell lines, and it is positively correlated with osteosarcoma development. Furthermore, we validated that circCAMSAP1 functions in osteosarcoma tumorigenesis through a circCAMSAP1/miR-145-5p/friend leukemia virus integration 1 (FLI1) pathway. Yes Silencing of circCAMSAP1 effectively suppresses osteosarcoma cell growth, apoptosis, migration, and invasion. 33664993 circHIPK3 CircRNA Homo sapiens Osteosarcoma OS tissue samples and OS cell lines regulation[miR-637/HDAC4 signaling] qRT-PCR//FISH//Transwell Assay It was revealed that circHIPK3 expression was upregulated in OS tissue samples and OS cell lines. It was demonstrated that circHIPK3 promoted OS cell proliferation, migration and invasion by modulating miR‑637/HDAC4 signaling. Yes Using loss‑of‑function proliferation and Transwell assays, the present study revealed that circHIPK3‑knockdown suppressed OS cell proliferation, migration and invasion. 33416147 hsa_circ_03955 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissue regulation[miR-3662/Metadherin Pathway] qRT-PCR Circ-03955 was significantly upregulated, and miR-3662 was downregulated in osteosarcoma.All these findings demonstrate that the presence of circ-03955 promotes EMT in osteosarcoma by acting as miR-3662 sponge-mediated MTDH expression. Yes Circ-03955 silencing inhibited the growth and metastasis of osteosarcoma. 33312941 hsa_circ_0000658 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines regulation[miR-1227/IRF2 axis] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//IHC//Transwell Assay The results of this study revealed that circ-0000658 exhibits low levels in OS tissues and cell lines. Conclusively, circ-0000658 modulates biological function of OS cells through the miR-1227/IRF2 axis. Yes Moreover, circ-0000658 repression promoted cell cycle, proliferation, invasion and migration but inhibited the apoptosis of OS cells. 33264494 hsa_circ_0032462 CircRNA Homo sapiens Osteosarcoma osteosarcoma cells regulation[Promoting KIF3B Expression] qRT-PCR//Wound Healing Assay//Invasion Assay//Migration Assay Using real-time polymerase chain reaction, we verified the elevated expression of circ_0032462 in osteosarcoma cells than normal cells.In addition, kinesin family member 3B inhibition was found to inhibit circ_0032462-induced enhanced osteosarcoma cell progression. Yes Functional validation experiments revealed that circ_0032462 overexpression promoted proliferation, migration, and invasion in osteosarcoma cells, whereas circ_0032462 silencing was observed to inhibit cancer cell progression (proliferation, migration, and invasion). 33153390 hsa-circ-0001146 CircRNA Homo sapiens Osteosarcoma Osteosarcoma tissues regulation[has-circ-0001146/miR-26a-5p/MNAT1 network ] qRT-PCR//RNA Pull-Down//Luciferase Report Assay Osteosarcoma tissues showed higher MNAT1 and has-circ-0001146 expression than adjacent normal tissues, although the expression of MNAT1 was not significantly up-regulated in sarcomas according to TCGA databases. The present study confirmed that has-circ-0001146 blocked miR-26a-5p targeting MNAT1 in osteosarcoma cells, thereby promoting the malignant behaviours of osteosarcoma cells. Yes The depletion of has-circ-0001146 or MNAT1 or the increase of miR-26a-5p inhibited osteosarcoma cell viability and invasion, and increased apoptosis. 32453410 hsa_circ_0136666 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines regulation[miR-593-3p/ZEB2 pathway] CCK8//qRT-PCR//Transwell Assay hsa_circ_0136666 was shown to be upregulated in OS and correlated with advanced stage and poor prognosis. Additionally, we identified hsa_circ_0136666 was a molecular sponge for miR-593-3p to facilitate ZEB2 expression. hsa_circ_0136666 was shown to be upregulated in OS and correlated with advanced stage and poor prognosis. Yes Functional investigation using CCK8, colony formation assay and Transwell assay demonstrated that hsa_circ_0136666 promoted OS proliferation, migration and invasion, but inhibited cell death. 32424109 hsa_circ_0000337 CircRNA Homo sapiens Osteosarcoma OS cell lines regulation[miR-4458/BACH1 pathway] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Circ_0000337 expression was upregulated in OS cell lines and it silence hindered OS cell proliferation and migration. This research for the first time documented that circ_0000337 promoted OS progression via sponging miR-4458 and thus elevating BACH1 expression, offering rational therapeutic target for OS. Yes Circ_0000337 expression was upregulated in OS cell lines and it silence hindered OS cell proliferation and migration. 32390598 hsa_circ_0002052 CircRNA Homo sapiens Osteosarcoma OS tissues regulation[miR-382/STX6 axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results of this research manifested that relative to that in non-tumor controls, circ-0002052 level was raised in OS tissues. Up-regulated circ-0002052 was associated with advanced stage, tumor size, and metastasis. Additionally, circ-0002052 elevation indicated a low survival rate in OS patients and silencing of circ-0002052 suppressed proliferation, migration, and invasion of OS cells. Yes Additionally, circ-0002052 elevation indicated a low survival rate in OS patients and silencing of circ-0002052 suppressed proliferation, migration, and invasion of OS cells. 32274658 circRAB3IP CircRNA Homo sapiens Osteosarcoma OS tissues and OS cells Interaction(miR-580-3p/TWIST1 axis) CCK8//qRT-PCR .In the present study, We found that circRAB3IP was highly expressed in OS tissues and OS cells. Moreover, circRAB3IP directly binds to miR-580-3p. TWIST1 is directly targeted by miR-580-3p. We also demonstrated that circRAB3IP act as the sponge of miR-580-3p to promote TWIST1 expression. CircRAB3IP promotes OS cells proliferation, migration, and invasion through modulating miR-580-3p/TWIST1 axis. High levels of circRAB3IP was correlated with advanced TNM stage, distant metastasis. Yes CircRAB3IP knockdown inhibited cell proliferation, migration, and invasion.Moreover, circRAB3IP facilitated tumor formation in vivo. 34224315 hsa_circ_0102049 CircRNA Homo sapiens Osteosarcoma OS cell lines Interaction(miR-520g-3p/PLK2 axis) CCK8//qRT-PCR Although circ_0102049 has been found to be highly expressed in OS cell lines. Here, we found that silence of circ_0102049 could significantly exacerbate the tumorigenesis of OS in vivo through sponging microRNA-520g-3p. Polo-like kinase 2 (PLK2) was predicted to be a target of miR-520g-3p, and luciferase reporter assay revealed that overexpression of miR-520g-3p dramatically suppressed the expression of PLK2, whereas miR-520g-3p inhibitor promoted the PLK2 expression. Yes Moreover, the silence of circ_0102049 could markedly promote the proliferation, invasion, migration and cell-cycle promotion while inhibiting the apoptosis of OS cell line MG63 cells in vitro through regulating miR-520g-3p/PLK2 axis. 34060415 circATRNL1 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells Interaction(miR-409-3p/LDHA) qRT-PCR//FISH Results indicated that expression of circATRNL1 was higher in osteosarcoma tissues and cells. Mechanistically, circATRNL1 up-regulated the expression level of LDHA, which was also targeted by miR-409-3p. Therefore, circATRNL1 exerted the accelerative roles of osteosarcoma aerobic glycolysis through miR-409-3p/LDHA axis. The high-expression of circATRNL1 was significantly correlated with aggressive features and acted as an independent risk factor for osteosarcoma patients' overall survival. Yes Functionally, our findings demonstrate that circATRNL1 promotes the osteosarcoma aerobic glycolysis in vitro. 34635009 circFOXP1 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues Interaction(microRNA -127-5p/CDKN2AIP signaling pathway) qRT-PCR//Western Blot We found that circFOXP1 expression was increased in osteosarcoma, and could promote angiogenesis in osteosarcoma through upregulating CDKN2AIP expression. Moreover, circFOXP1 could directly bind to miR-127-5p, which further targets CDKN2AIP directly. Yes We found that circFOXP1 expression was increased in osteosarcoma, and could promote angiogenesis in osteosarcoma through upregulating CDKN2AIP expression. 34637672 circCRIM1 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(miR-513) qRT-PCR//Luciferase Report Assay The results demonstrated that the expression of circCRIM1 was notably decreased both in OS tissues and cell lines. Further mechanistic studies indicated that circCRIM1 served as a competing endogenous RNA (ceRNA) of miR-513, leading to decreases in the proliferation, migration, and invasion of OS cells. Taken together, our data uncovered a significant role of the circCRIM1/miR-513 pathway in the proliferation, migration, and invasion of OS cell lines and suggested that circCRIM1 may serve as a possible therapeutic target for OS treatment. Depressed circCRIM1 expression was correlated with lymph node metastasis, advanced FIGO stage, and low overall survival of OS patients. Yes In addition, the results indicated that circCRIM1 could decrease the migration, invasion, and growth of OS cells. 34480205 hsa_circ_0008932 CircRNA Homo sapiens Osteosarcoma OS tumors, Interaction(miR-145-5p) qRT-PCR The results suggested that circ_0008932 was upregulated in most primary OS tumors, suggesting that circ_0008932 is associated with the development of OS. A luciferase reporter assay revealed that circ_0008932 may downregulate microRNA (miR)-145-5p through direct binding. Furthermore, the expression of miR-145-5p was negatively correlated with circ_0008932 levels in OS specimens. In addition, further functional studies indicated that miR-145-5p inhibitors eliminated the effects caused by si-circ_0008932 in OS cells. Yes In the in vitro assays, si-circ_0008932 inhibited the proliferation, migration and invasion of OS cells, while apoptosis was promoted. 34504560 circVRK1 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues Interaction(miR-337-3p/ZNF652 axis) qRT-PCR//Transwell Assay We demonstrated that circVRK1 was a stable circular transcript localized in the cytoplasm of osteosarcoma cells, and the down-regulation of circVRK1 in osteosarcoma tissues was related to poor outcome of patients. Mechanistically, circVRK1 was assumed to be a microRNA sponge for miR-337-3p, and ZNF652 was the downstream gene of miR-337-3p. CircVRK1 overexpression or miR-337-3p knockdown accelerated ZNF652 expression, and up-regulated miR-337-3p efficiently abolished the promotion of ZNF652 induced by circVRK1. We demonstrated that circVRK1 was a stable circular transcript localized in the cytoplasm of osteosarcoma cells, and the down-regulation of circVRK1 in osteosarcoma tissues was related to poor outcome of patients. Yes Meanwhile, over-expressed circVRK1 obviously restrained the growth, migration, and invasion of osteosarcoma in vitro and in vivo. 34424826 circNRIP1 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells Interaction(miR-532-3p/AKT3/PI3K/AKT Axis) qRT-PCR//Luciferase Report Assay//Transwell Assay circNRIP1 was upregulated in osteosarcoma tissues and cells. Co-culture data showed that BMSC-EVs could transfer circNRIP1 into osteosarcoma cells where it competitively bound to miR-532-3p and weakened miR-532-3p's binding ability to AKT3. By this mechanism, the PI3K/AKT signaling pathway was activated and the malignant characteristics of osteosarcoma cells were stimulated. Yes Overexpression of circNRIP1 promoted the proliferative, migratory, and invasive potential of osteosarcoma cells. 34660257 hsa_circ_0007534 CircRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-219a-5p/SOX5 axis) qRT-PCR//RIP The levels of circ_0007534 and SOX5 were increased, while the miR-219a-5p level was decreased in OS tissues and cells.Circ_0007534 targeted miR-219a-5p, and miR-219a-5p interacted with SOX5. Furthermore, circ_0007534 regulated the growth of OS cells through modulating the levels of miR-219a-5p and SOX5. Yes Circ_0007534 knockdown repressed the proliferation, colony formation, migration, and invasion in OS cells. 33552887 circATP2A2 CircRNA Homo sapiens Osteosarcoma OS tissues Regulation(miR-335-5p/MYH9) qRT-PCR//Western Blot circATP2A2 and MYH9 were upregulated while miR-335-5p was downregulated in OS. circATP2A2 accelerated OS cell malignancy and glycolysis through upregulating MYH9 via sponging miR-335-5p, offering a promising target for OS treatment. OS patients with high circATP2A2 expression displayed a shorter overall survival and the area under curve of circATP2A2 was 0.77, manifesting that circATP2A2 might be a diagnostic and prognostic biomarker. Yes circATP2A2 silencing repressed OS cell proliferation and glycolysis in vivo and constrained OS cell proliferation, glycolysis, migration, and invasion in vitro. 34901459 circATAD1 CircRNA Homo sapiens Osteosarcoma OS tissues Interaction(miR-154-5p) qRT-PCR//RNA Pull-Down Circ-ATAD1 was overexpressed in OS compared to non-tumor tissues and was detected in the nuclei of OS cells. Mature miR-154-5p, but not premature miR-154-5p, was downregulated in OS tissues compared to non-tumor tissues and was inversely correlated with circ-ATAD1.n OS cells, circ-ATAD1 overexpression decreased the expression of mature miR-154-5p, but not premature miR-154-5p. Yes Transwell assay analysis showed that circ-ATAD1 overexpression increased cell invasion and migration, and mature miR-154-5p overexpression suppressed these cell behaviors. 34857012 hsa_circ_0000073 CircRNA Homo sapiens Osteosarcoma OS cell lines Interaction(miR-1252-5p/CCNE2 and MDM2 ) qRT-PCR//Western Blot hsa_circ_0000073 was highly expressed in OS cell lines and could promote OS progression, including proliferation, migration, invasion, and cell cycle in vitro as well as tumorigenesis in vivo. Mechanically, hsa_circ_0000073 could readily downregulate the expression of CCNE2 and MDM2 through miR-1252-5p. Yes hsa_circ_0000073 was highly expressed in OS cell lines and could promote OS progression, including proliferation, migration, invasion, and cell cycle in vitro as well as tumorigenesis in vivo. 34568326 hsa_circ_0032463 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(MicroRNA 498/LEF1 Axis) qRT-PCR//Luciferase Report Assay Our findings revealed that circ_0032463 expression was upregulated in OS tissues and cell lines. Overall, this research suggested that circ_0032463 could promote OS development by regulating the miR-498/LEF1 axis. Yes We also found that circ_0032463 interacted with miR-498, thereby reducing the expression of miR-498 in OS cells. Experimental results indicated that miR-498 could directly target LEF1 in OS cells and that circ_0032463 could abrogate the tumor-inhibitory effect of miR-498 by upregulating LEF1 in OS. More specifically, by binding to miR-498 and inhibiting LEF1 expression, circ_0032463 promoted the migration and proliferation abilities of OS cells and suppressed the apoptosis ability of OS cells. 34096776 circPVT1 CircRNA Homo sapiens Osteosarcoma OS cell Interaction(miR-423-5p/Wnt5a/Ror2 signaling pathway) qRT-PCR//Western Blot circPVT1 interacted with miR-423-5p and activated Wnt5a/Ror2 signaling by sponging miR-423-5p. Yes Knockdown of circPVT1 or overexpression of miR-423-5p suppressed OS tumor growth and metastasis in vivo. miR-423-5p inhibited OS glycolysis, proliferation, migration, and metastasis by targeting and suppressing Wnt5a/Ror2 signaling pathway, while circPVT1 promoted those processes by acting as a sponge of miR-423-5p. 33369809 hsa_circ_0010220 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells Interaction(miR-198/Syntaxin 6 axis) qRT-PCR//RNA Pull-Down//RIP Circ_0010220 was elevated in osteosarcoma tissues and cells, and was related to the lower survival rate of osteosarcoma patients. Mechanistic research revealed that miR-198 is a target of circ_0010220, and directly targets STX6. Moreover, circ_0010220 upregulated the expression of STX6 by sponging miR-198 to regulate cell proliferation, migration, invasion, cell cycle, and apoptosis. Circ_0010220 was elevated in osteosarcoma tissues and cells, and was related to the lower survival rate of osteosarcoma patients. Yes Circ_0010220 knockdown inhibited cell proliferation, migration and invasion, but induced cell cycle arrest and apoptosis in vitro. Besides, circ_0010220 silence curbed the growth of xenograft osteosarcoma tumors in vivo. 33996428 hsa_circ_0005721 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Interaction(miR-16-5p/TEP1) qRT-PCR//Transwell Assay hsa_circ_0005721 was upregulated in osteosarcoma tissues and cell lines.Serving as a ceRNA, hsa_circ_0005721 upregulated the linear transcript TEP1 by competitively binding miR-16-5p, thus exerting its biological functions in regulating osteosarcoma development. Yes Knockdown of hsa_circ_0005721 suppressed proliferative and metastatic rates of U-2OS and Saos-2 cells, and stimulated apoptosis. 34565023 hsa_circ_0000527 CircRNA Homo sapiens Osteosarcoma hFOB1.19 cells Regulation(miR-646/ARL2 axis) CCK8//qRT-PCR We demonstrated that circ_0000527 sponges miR-646 in osteosarcoma cells and that ARL2 is a target gene of miR-646. MiR-646 expression was decreased and ARL2 was overexpressed in osteosarcoma cells (SAOS-2, HOS, MG-63 and U2OS) compared to hFOB1.19 cells. Overexpression of circ_0000527 was demonstrated to induce ARL2 expression in MG-63 cells. We showed that miR-646 was downregulated in osteosarcoma specimens compared to that of non-tumor specimens and that the level of circ_0000527 was negatively correlated with miR-646 expression in osteosarcoma specimens. The elevated expression of circ_0000527 was shown to promote cell growth and cell cycle progression by modulating miR-646 expression. The ectopic expression of circ_0000527 was shown to promote cell growth, cell cycle progression and the secretion of inflammatory mediators by modulating ARL2. The present study suggested that the circ_0000527/miR-646/ARL2 axis may be a potential treatment target for osteosarcoma. Yes Overexpression of circ_0000527 was demonstrated to induce ARL2 expression in MG-63 cells. 33617480 circCNST CircRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-578-LDHA/PDK1 ceRNA networks) qRT-PCR//MTT Circ-CNST was upregulated in human OS tissues and cells, accompanied with downregulation of miR-578 and upregulation of LDHA and PDK1. There were negative correlations between miR-578 expression and circ-CNST or LDHA/PDK1 in OS tissues. Physically, miR-578 was targeted by circ-CNST, and miR-578 could target LDHA/PDK1. Moreover, high circ-CNST/LDHA/PDK1 or low miR-578 might predict shorter overall survival, advanced TNM stages, and lymph node metastasis. Yes Functionally, blocking circ-CNST and restoring miR-578 enhanced apoptosis rate and suppressed cell proliferation, colony formation, migration, and invasion in 143B and U2OS cells, accompanied with decreased glucose consumption, lactate production, and adenosine triphosphate (ATP)/adenosine diphosphate (ADP) ratio. Furthermore, in vivo growth of U2OS cells was retarded by silencing circ-CNST. 33962616 circITCH CircRNA Homo sapiens Osteosarcoma 40 paired OS tissue and normal tissue samples Interaction(miR-524/RASSF6 axis) Flow Cytometry//qRT-PCR//Transwell Assay Down-regulation of circITCH and RASSF6, as well as the up-regulation of miR-524, was revealed in OS by investigating 40 paired OS tissue and normal tissue samples. circITCH sponged miR-524 to up-regulate RASSF6, causing OS progression inhibition and DXR resistance reduction. Yes Overexpression of circITCH lowered the cell viability, IC50 value of DXR, migration and invasion, whereas it facilitated apoptosis of OS cells. Additionally, circITCH up-regulation reduced tumor growth in vivo. 34151476 hsa_circ_0032463 CircRNA Homo sapiens Osteosarcoma OS tissues and OS cell lines Interaction(miR‑330‑3p/PNN axis) qRT-PCR//Transwell Assay The findings indicated that circ_0032463 and PNN were highly expressed in OS tissues and OS cell lines, and that they facilitated cell proliferation, viability, invasion and adhesion, but attenuated cell apoptosis in OS cells. It was also noted that circ_0032463 inhibited miR‑330‑3p to upregulate PNN expression. In conclusion, this study confirmed that by regulating the miR‑330‑3p/PNN axis, Yes The findings indicated that circ_0032463 and PNN were highly expressed in OS tissues and OS cell lines, and that they facilitated cell proliferation, viability, invasion and adhesion, but attenuated cell apoptosis in OS cells. 33786605 circCDK14 CircRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-520a-3p/GAB1 axis) Transwell Assay//qRT-PCR//Colony Formation Assay//Western Blot Circ_CDK14 and GAB1 expression was upregulated, while miR-520a-3p was downregulated in OS tissues and cells. Circ_CDK14 could sponge miR-520a-3p. miR-520a-3p targeted GAB1 to repress OS cell proliferation and metastasis. Yes Circ_CDK14 depletion hindered OS cell proliferation, metastasis, and tumorigenesis while facilitated apoptosis, which were all ameliorated by miR-520a-3p inhibition. Circ_CDK14 knockdown blocked OS tumor growth in vivo. 34348465 hsa_circ_0008259 CircRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-21-5p) CCK8//qRT-PCR//Transwell Assay//FISH Circ_0008259 expression and PDCD4 expression were down-regulated and miR-21-5p expression was elevated in the OS tissues and cells.Besides, PDCD4 was validated as the target gene of miR-21-5p, and circ_0008259 could competitively bind to miR-21-5p, thus up-regulating PDCD4 expression in OS cells. Yes Functional experiments showed that circ_0008259 overexpression significantly inhibited the proliferation and metastatic potential of OS cells and promoted the apoptosis. 34905503 circARF3 CircRNA Homo sapiens Osteosarcoma osteosarcoma cell lines and tumor tissues regulation[miR-1299,CDK6 ] qRT-PCR//Luciferase Report Assay In this study we found that circ_ARF3 were highly expressed in osteosarcoma cell lines and tumor tissues.In general, our study demonstrated that in the OS, highly expressed circ_ARF3 acts as a sponge of miR-1299 to inhibit miR-1299 mediated CDK6 downregulation which further promoted OS pathogenesis. Yes Knocking down circ_ARF3 greatly ceased OS cell growth, impaired cell colony formation and halted cell cycle transition from G1 to S phase. 32240746 hsa_circ_0008792 CircRNA Homo sapiens Osteosarcoma osteosarcoma cells regulation[Hsa-miR-711/ZFP1] Flow Cytometry//Wound Healing Assay//Transwell Assay Hsa_circ_0008792 is expressed at low levels in osteosarcoma cells, and up-regulation of hsa_circ_0008792 could suppress osteosarcoma cell migration and invasion and promote apoptosis.Osteosarcoma is suppressed by hsa_circ_0008792/hsa-miR-711/ZFP1 axis. Yes Hsa_circ_0008792 is expressed at low levels in osteosarcoma cells, and up-regulation of hsa_circ_0008792 could suppress osteosarcoma cell migration and invasion and promote apoptosis. 32210583 hsa_circ_0001105 CircRNA Homo sapiens Osteosarcoma OS tissues regulation[miR-766/YTHDF2 signaling pathway] Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay Data showed that circ_0001105 and YTHDF2 were significantly lower, while miR-766 was higher in OS tissues compared to adjacent tissues.Our findings suggest that circ_0001105 inhibits OS progression, at least partially, by regulating miR-766/YTHDF2 signaling pathway. Low expression of circ_0001105 or YTHDF2 was associated with poor survival of OS patients as demonstrated by the Kaplan-Meier analysis. Yes Ectopic overexpression of circ_0001105 or YTHDF2 significantly suppressed OS cell viability and invasion through regulating miR-766. Last, overexpression of circ_0001105 significantly attenuated in vivo tumor growth. 32161468 hsa_circ_0060428 CircRNA Homo sapiens Osteosarcoma cells regulation[RPBJ] CCK8//qRT-PCR//Luciferase Report Assay//Flow Cytometry In present study, we identified an elevated expressed circ-0060428 in osteosarcoma cells.Altogether, we confirmed the up-regulated circ-0060428 could improve the proliferation and survival of osteosarcoma cells by sponging miR-375 to upregulate RBPJ expression. Yes The results of CCK-8 and flow cytometry assay showed that circ-0060428 promoted cell proliferation and reduced cell apoptosis of osteosarcoma cells. 32130980 circPVT1 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines regulation[ miR-205-5p/c-FLIP Axis ] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot circPVT1 and c-FLIP were highly expressed, while miR-205-5p was lowly expressed in OS tissues and cell lines. Our study demonstrated circPVT1 functions as a sponge for miR-205-5p to promote c-FLIP expression, thereby enhancing EMT and inducing OS invasion and metastasis in vitro, implying that circPVT1 might be a potential therapeutic target for further clinical therapy of OS. Yes Knockdown of circPVT1 repressed cell proliferation, migration and invasion via inhibiting epithelial-mesenchymal transition (EMT) in OS. 32110097 circEPSTI1 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues regulation[circEPSTI1-miR-892b-MCL1 axis ] qRT-PCR We found that circEPSTI1 was significantly upregulated in osteosarcoma. Thus, the circEPSTI1-miR-892b-MCL1 axis affected osteosarcoma progression through the miRNA sponging mechanism. Yes Inhibition of circEPSTI1 suppressed the osteosarcoma cancer cell proliferation and migration in vitro. 31702512 circPIP5K1A CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues Interaction(miR-515-5p/YAP axis) Western Blot//Flow Cytometry//IF//Luciferase Report Assay//Cell Viability Assay//Transwell Assay CircPIP5K1A expression was significantly enhanced in clinical osteosarcoma tissues compared with the adjacent normal tissues. Yes The depletion of circPIP5K1A by siRNA repressed osteosarcoma cell viabilities and induced osteosarcoma cell apoptosis. The suppression of circPIP5K1A attenuated the capabilities of invasion and migration of osteosarcoma cells. The circPIP5K1A knockdown increased E-Cadherin expression and decreased Vimentin expression in osteosarcoma cells. 34774083 circUBAP2 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(miR‑204‑3p/HMGA2 axis) Western Blot//Flow Cytometry//qRT-PCR//CCK8//RIP//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay The results demonstrated that circUBAP2 expression was significantly upregulated in OS tissues and cell lines compared with paracancerous tissues and hFOB1.19 cells, respectively. In addition, high circUBAP2 expression levels in patients with OS were associated with a lower survival rate compared with lower expression levels in patients with OS. Yes The functional assays revealed that circUBAP2 knockdown significantly inhibited OS cell proliferation, migration and invasion, but increased OS cell apoptosis compared with the small interfering RNA‑negative control (si‑NC) group. The dual‑luciferase reporter and RIP assay results confirmed that circUBAP2 bound to miR‑204‑3p. 33650644 circUSP34 CircRNA Homo sapiens Osteosarcoma OS cells (KHOS and 143B cell lines) Interaction(miR-16-5p ) qRT-PCR//FISH//Western Blot Based on the inhibited effect of miR-16-5p reported on OS, circUSP34 was analyzed as a sponge of miR-16-5p via Starbase. Yes We found that circUSP34 promoted the proliferation, migration, and invasion of OS in vitro and in vivo. Function assays showed that the malignancy of OS cells, including proliferation, migration, and invasion, was inhibited after knocking out circUSP34.  34592064 circFAM120B CircRNA Homo sapiens Osteosarcoma OS tissue and cell lines Interaction(miR-1205/PTBP1 axis) CCK8//qRT-PCR//RNA Pull-Down CircFAM120B and the transcription factor, PTBP1 were elevated in OS tissue and cell lines, while miR-1205 was poorly expressed. CircFAM120B also appeared to function as an miR-1205 sponge, as miR-1205 bound to PTBP1. Interestingly, overexpressed PTBP1 (or miR-1205 inhibition) reversed the inhibitory effects mediated by circFAM120B downregulation in OS cells. Yes Silenced circFAM120B significantly suppressed in vitro OS cell proliferation and invasion, and inhibited in vivo tumor growth. 34716285 hsa_circ_0002137 CircRNA Homo sapiens Osteosarcoma osteosarcoma tumours Interaction(miR-433-3p/ IGF1R axis) qRT-PCR//Luciferase Report Assay//Transwell Assay In our study, we implicated a circRNA hsa_circ_0002137, which was higher expressed in osteosarcoma tumours compared with paracancerous tissue. In conclusion, it was demonstrated that circ_0002137 could restrain the progression of OS through regulating miR-433-3p/IGF1R axis. Yes It was proved that down-regulation of circ_0002137 suppressed the progress of OS, including cell invasion, cell cycle and cell apoptosis. 33621401 circSIPA1L1 CircRNA Homo sapiens Osteosarcoma human OS samples and OS cell lines Interaction( miR-411-5p/RAB9A Signaling Pathway ) qRT-PCR//Luciferase Report Assay Our study confirmed circSIPA1L1 to be upregulated in both human OS samples and OS cell lines. Mechanistically, circSIPA1L1 could serve as a miR-411-5p molecular sponge to increase RAB9A expression, which was confirmed to be a tumor promoter mediating carcinogenesis. Yes Silencing of circSIPA1L1 attenuated the vitality, invasion, migration and proliferation of OS cell lines both in vivo and in vitro. miR-411-5p inhibition or RAB9A overexpression reversed the anti-tumor effects caused by circSIPA1L1 knockdown. Briefly, circSIPA1L1 could function as a driver gene in OS and initiate OS tumorigenesis through the miR-411-5p/RAB9A signaling pathway, which might become a potential therapeutic biomarker for OS treatment. 33968929 hsa_circ_001422 CircRNA Homo sapiens Osteosarcoma OS cell lines and tissues Interaction(miR-195-5p/FGF2/PI3K/Akt axis) qRT-PCR//RNA-seq We characterized a novel and abundant circRNA, circ_001422, that promoted OS progression. Circ_001422 expression was dramatically increased in OS cell lines and tissues compared with noncancerous samples. Mechanistically, competitive interactions between circ_001422 and miR-195-5p elevated FGF2 expression while also initiating PI3K/Akt signaling. These events enhanced the malignant characteristics of OS cells. Higher circ_001422 expression correlated with more advanced clinical stage, larger tumor size, higher incidence of distant metastases and poorer overall survival in OS patients. Yes Circ_001422 knockdown markedly repressed the proliferation and metastasis and promoted the apoptosis of OS cells in vivo and in vitro, whereas circ_001422 overexpression exerted the opposite effects. 34271943 hsa_circ_103801 CircRNA Homo sapiens Osteosarcoma OS patients' tissues Interaction(miR-3388-3p-HIF-1/Rap1/PI3K-Akt pathway) qRT-PCR//Western Blot The results showed that the expression level of circRNA_103801 was significantly up-regulated in OS patients' tissues. The results of the luciferase reporter assay suggested that circRNA_103801 could be combined with miR-338-3p, and the RT-qPCR revealed that the miR-338-3p level in OS cells after knockdown of circRNA_103801 was elevated compared with the control group. The results of Western blotting suggested that the expression levels of HIF-1, Rap1, PI3K, and Akt were elevated in OS cells. Yes Inhibiting the expression level of circRNA_103801 could attenuate the proliferation, migration, and invasion abilities of OS cells. In addition, the down-regulated expression level of circRNA_103801 could induce cell apoptosis. 34157832 circMTO1 CircRNA Homo sapiens Osteosarcoma cell lines Interaction(miR-630/KLF6 axis) qRT-PCR//Western Blot Here, we measured 20 circRNAs which were downregulated in osteosarcoma tissues using circRNA microarray. CircMTO1 expression was decreased in osteosarcoma cell lines. Bioinformatics analysis showed that circMTO1 serves as a sponge for miR-630 and KLF6 is a direct target of miR-630. Furthermore, circMTO1 functions through regulation of miR-630/KLF6 axis. Yes Besides, circMTO1 could inhibit cell proliferation, migration and invasion, and induced apoptosis in osteosarcoma cells. 33506896 circANKIB1 CircRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-217/PAX3 axis) qRT-PCR CircANKIB1 and PAX3 were high-expressed, whereas miR-217 was low-expressed in OS tissues and cells. MiR-217 was a direct target of circANKIB1, and its inhibition reversed the inhibitory effect of circANKIB1 knockdown on the progression of OS cells. Moreover, PAX3 was a direct target of miR-217, and miR-217 exerted the anti-tumor role in OS cells by targeting PAX3. F Yes Knockdown of circANKIB1 inhibited the progression of OS by reducing cell proliferation, migration, invasion, and tumor growth (in vivo), and inducing apoptosis. 33552886 circMUC16 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer cells Interaction(miR-1182/S100B signaling pathway) Wound Healing Assay//qRT-PCR//RIP//MTT//Transwell Assay Propofol inhibited ovarian cancer cell proliferation, glycolysis metabolism, migration and invasion, which were partly recovered by circ_MUC16 overexpression. Circ_MUC16 was downregulated in Propofol-treated ovarian cancer cells. MiR-1182 was a target of circ_MUC16, and circ_MUC16 knockdown-inhibited cell proliferation, glycolysis metabolism, migration and invasion were partly restored by miR-1182 inhibition. In addition, S100B was a target of miR-1182, and miR-1182-suppressed cell proliferation, glycolysis metabolism, migration and invasion were partly restored by S100B overexpression. Yes Propofol inhibited ovarian cancer cell proliferation, glycolysis metabolism, migration and invasion, which were partly recovered by circ_MUC16 overexpression. Besides, circ_MUC16 knockdown enhanced the effects of Propofol to further inhibit tumor growth in vivo. 34837947 circPTK2 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Interaction(miR-639/FOXC1 ) qRT-PCR//IF//IHC//FISH Circ-PTK2 expression was significantly higher in the ovarian cancer tissues compared with normal ovary tissues (P < 0.001). The RNA level of miR-639 was negatively correlated to cell proliferation and migration, whereas the mRNA level of FOXC1 was positively correlated to those processes. miR-639 mimics reversed the function of circ-PTK2 overexpression; however, interference of FOXC1 mRNA also reversed the function of circ-PTK2. Yes Overexpression of circ-PTK2 enhanced tumor formation and was correlated to expression of EMT pathway markers. 34034740 hsa_circ_0013958 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-637/PLXNB2 Axis) IHC//Western Blot//CCK8//qRT-PCR//RIP//Colony Formation Assay Circ_0013958 and PLXNB2 were upregulated, while miR-637 was downregulated in OC tissues and cells. Circ_0013958 acted as a sponge for miR-637 to regulate the expression of PLXNB2 in OC cells. And miR-637 targeted PLXNB2 to suppress OC cell proliferation, migration, and invasion. Moreover, circ_0013958 silencing blocked OC tumor growth in vivo. Circ_0013958 knockdown impeded OC development through modulating the miR-637/PLXNB2 axis, highlighting a therapeutic target for OC. Yes The repression effects of circ_0013958 knockdown on cell proliferation, migration, invasion, and apoptosis in OC cells were partly attenuated by the miR-637 inhibitor. 34367233 circPRKCI CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[regulating E2E7] qRT-PCR//FISH The level of circ-PRKCI was significantly higher in HCC tissues than in tumor adjacent tissues, and in HCC cell lines than in cells lines of esophageal, liver, stomach, and colon cancers.And clinical data suggested that the distribution of circ-PRKCI rose with the depth of invasion, lymph node metastasis, distant metastasis, and TNM stage, indicating that circ-PRKCI may affect the survival and prognosis of patients with HCC by regulating E2E7. The level of circ-PRKCI was significantly higher in HCC tissues than in tumor adjacent tissues, and in HCC cell lines than in cells lines of esophageal, liver, stomach, and colon cancers.And clinical data suggested that the distribution of circ-PRKCI rose with the depth of invasion, lymph node metastasis, distant metastasis, and TNM stage, indicating that circ-PRKCI may affect the survival and prognosis of patients with HCC by regulating E2E7. Yes A series of functional tests showed that circ-PRKCI substantially inhibited cell apoptosis and promoted cell invasion. 31086464 circMAT2B CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation[ miR-338-3p/PKM2 Axis] RNA Pull-Down//Luciferase Report Assay//RIP//FISH CircMAT2B expression was up-regulated in HCC tissues and cell lines.CircMAT2B promoted HCC progression by enhanced glycolysis by activating the circMAT2B/miR-338-3p/PKM2 axis under hypoxia, which may provide a therapeutic target for HCC. HCC patients with high circMAT2B expression had shortened overall survival. Yes Functional assays were performed in HCC cells, HCC organoids, and nude mice to explore the tumor-promoting roles of circMAT2B in HCC. 31004447 circVAPA CircRNA Homo sapiens Carcinoma, Hepatocellular cell lines Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining circVAPA was upregulated in HCC cell lines and circVAPA depletion was associated with decreased HCC cell proliferation. This study revealed that circVAPA contributes to HCC cell proliferation through sponging miR-377-3p and thereby disinhibiting PSAP, shedding light on a new insight into HCC initiation and progression. Yes circVAPA was upregulated in HCC cell lines and circVAPA depletion was associated with decreased HCC cell proliferation. 31368365 hsa_circ_0005075 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[sponging miR-335] qRT-PCR We found circ_0005075 was upregulated in HCC tissues. Our data provide evidence that circ_0005705 promotes the HCC progression by sponging miR-335 and further regulating MAPK1 expression. Yes HCC progression was suppressed by downregulation of circ_0005075 in vitro and in vivo, and the suppression was partially reversed by inhibition of microRNA-335 (miR-335) expression. 31054187 circZFR CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[ regulating miR-3619-5p/CTNNB1 axis and activating Wnt/β-catenin pathway] qRT-PCR We then detect the expression of circZFR in HCC tissues using qRT-PCR. In summary, our findings indicated that circZFR may exert carcinogenic role in HCC through regulating miR-3619-5p/CTNNB1 axis and activating Wnt/β-catenin pathway. These findings may provide a novel perspective for the treatment of hepatocellular carcinoma. Furthermore, Kaplan-Meier method and log rank test revealed that high expression of circZFR was associated with the poor prognosis of patients with HCC. Yes Subsequently, loss-of-function assay indicated that circZFR knockdown significantly suppressed cell proliferation and epithelial-mesenchymal transition (EMT) in HCC. 30468709 hsa_circ_0003418 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Expression[lower expressed] CCK8//qRT-PCR//Western Blot//Transwell Assay The expression level of circ_0003418 was downregulated in HCC tissues and cell lines, and the level correlated with tumor size, TNM stage and HBsAg level in HCC patients. The expression level of circ_0003418 was downregulated in HCC tissues and cell lines, and the level correlated with tumor size, TNM stage and HBsAg level in HCC patients. Yes circ_0003418 knockdown promoted HCC cells' proliferation, migration, and invasion. 31807029 hsa_circ_0015756 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[ miR-7] MTT//Luciferase Report Assay The expression level of circ_0015756 was increased and the expression level of miR-7 was diminished in cancerous liver tissues relative to noncancerous liver tissues. Importantly, we showed circ_0015756 could up-regulate FAK via targeting miR-7. Yes Circ_0015756 knockdown was shown to increase the expression of miR-7, reduce the proliferation, invasion, migration and resistance to apoptosis, and down-regulate the expression of FAK in HCC. These in vitro findings were reproduced in vivo that circ_0015756 knockdown decreased HCC xenograft growth. 31522588 hsa_circ_0000885 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Regulation[upregulating Caprin1] Western Blot//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay Circ_0000885 was highly expressed in HCC tissues than that in adjacent samples.The expression of circ_0000885 was also higher in HCC cell lines. Circ_0000885 could enhance cell proliferation and regulate cell cycle of HCC by promoting Caprin1. The miR-532-5p expression was associated with lymphatic metastasis and TNM stage. Yes The cell growth ability of HCC cells was inhibited after circ_0000885 was silenced. 31599409 circEPHB4 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[inhibition of HIF-1α ] qRT-PCR The expression of circ-EPHB4 was found to be downregulated in HCC tumor tissues.In conclusion, circ-EPHB4 is a tumor inhibitor in HCC and functions by inhibiting HIF-1α expression. Yes The expression of circ-EPHB4 was found to be downregulated in HCC tumor tissues, whereas circ-EPHB4 overexpression suppressed cell viability, induced apoptosis, and inhibited cell migration and invasion in Huh7 and HepG2 cells. 30644610 circLARP4 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Regulation[miR-761/RUNX3/p53/p21 signaling ] Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining Downregulated circLARP4 level was observed in HCC tissues and cell lines. Our study revealed the role of circLARP4/miR-761/RUNX3/p53/p21 signaling in HCC progression, providing a potential survival predictor and therapeutic candidate for HCC. Low expression level of circLARP4 independently predicted poor survival outcome. Yes Gain-of-function and loss-of-function assays demonstrated that circLARP4 suppressed HCC cell proliferation, mediated cell cycle arrest and induced senescence in vitro. 30520539 circZFR CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Regulation[miR-511/AKT1 axis ] Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of circZFR was enhanced and the expression of miR-511 was down-regulated in HCC tissues and cells. circZFR promotes HCC progression by directly down-regulating miR-511 to activate AKT1 signaling, suggesting that circZFR is a potential target in HCC treatment. Targeting circZFR may provide therapeutic benefits for HCC. Yes Functionally, circZFR silencing or miR-511 overexpression suppressed cell proliferation, migration and invasion, and induced apoptosis of HCC cells. 31147216 hsa_circ_104348 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells interaction[miR-187-3p/RTKN2 axis, Wnt/β-catenin pathway] IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//IF//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In the present study, we clarified that hsa_circRNA_104348 was dramatically upregulated in HCC tissues and cells. Taken together, these findings indicated that circular RNA hsa_circRNA_104348 might function as a competing endogenous RNA (ceRNA) to promotes HCC progression by targeting miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway. Patients with HCC displaying high hsa_circRNA_104348 level possessed poor prognosis. Yes Has_circ_104348 facilitated proliferation, migration, and invasion, meanwhile suppressed apoptosis of HCC cell. 33311442 circASAP1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines interaction[miR-326/miR-532-5p-MAPK1/CSF-1 signaling ] circRNA-seq CircASAP1 was overexpressed in HCC cell lines with high metastatic potential and in metastatic HCCs.We identified circASAP1 as a key regulator of HCC metastasis that acts on miR-326/miR-532-5p-MAPK1/CSF-1 signaling and serves as a prognostic predictor in patients with HCC. Yes In vitro, circASAP1 promoted cell proliferation, colony formation, migration, and invasion, and in vivo, it enhanced tumor growth and pulmonary metastasis. 31838741 hsa_circ_0014717 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue and cells regulation[miR-668-3p/BTG2 Axis] RNA Pull-Down//Western Blot//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay It was shown that circ_0014717 was significantly decreased in HCC. In conclusion, our findings illustrated a novel circ_0014717/miR-668-3p/BTG2 regulatory signaling pathway in HCC. Yes Then, we observed overexpression of circ_0014717 obviously repressed HCC cell growth, migration and invasion. 33598424 hsa_circ_0004277 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines,blood Expression[highly expressed] qRT-PCR//Transwell Assay We found that circ-0004277 was significantly upregulated in HCC cells, tissues, and plasma exosomes compared to that in normal controls. Yes Overexpression of circ-0004277 enhanced the proliferation, migration, and epithelial-mesenchymal transition (EMT) of HCC cells in vivo and in vitro. 33511111 circARNT2 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines regulation[miR-155-5p/PDK1 Axis] qRT-PCR The qRT-PCR analysis was to investigate the expression pattern of circARNT2 in HCC patient tissues and cell lines. In summary, our study demonstrated that circARNT2 modulates cisplatin resistance through miR-155-5p/PDK1 pathway. Yes In vitro experiments showed that knockdown of circARNT2 inhibited cell proliferation and enhances the cisplatin sensitivity of HCC cells. 33425483 circPVT1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-377/TRIM23 Axis] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay CircPVT1 and TRIM23 levels were elevated, while miR-377 was decreased in HCC.CircPVT1 aggravated the progression of HCC by upregulating TRIM23 via sponging miR-377. Yes CircPVT1 knockdown restrained proliferation and glycolysis, but enhanced apoptosis in HCC cells. 33364841 hsa_circ_102272 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Expression[highly expressed] CCK8//qRT-PCR//Luciferase Report Assay CircRNA_102272 expression was upregulated in HCC tissues and cells. Yes CircRNA_102272 knockdown suppressed HCC cell proliferation and decreased cisplatin-resistance. 33324096 circSMYD4 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells interaction[sponging miR-584-5p] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircSMYD4 was down-regulated in HCC tissues and cells, and was not easily affected by RNase R and Actinomycin D.CircSMYD4 prevents the development of HCC through regulating multiple signaling pathways such as metastasis and apoptosis by sponging miR-584-5p. Yes Up-regulation of circSMYD4 inhibited the proliferation, invasion and migration and promoted the apoptosis of HCC cells in vitro, while it inhibited tumor growth, promoted apoptosis-related proteins, and suppressed alpha-fetoprotein (AFP) levels in vivo. 33292243 hsa_circ_0006916 CircRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues and cells regulation[miR-337-3p/STAT3 axis] qRT-PCR//Luciferase Report Assay//RIP Hsa_circ_0006916 was substantially overexpressed in hepatocellular carcinoma tissues and cells.Our data suggest a novel hsa_circ_0006916/miR-337-3p/STAT3 axis in hepatocellular carcinoma, and provide a new target for treatment. High levels of hsa_circ_0006916 in hepatocellular carcinoma patients were associated with advanced clinical characteristics. Yes Down-regulation of hsa_circ_0006916 decreased the growth and invasion of hepatocellular carcinoma cells in vitro. 33292166 hsa-circ-0046600 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[miR-640/HIF-1α Signalling Pathway] qRT-PCR//Western Blot//Luciferase Report Assay//FISH The expression level of hsa-circ-0046600 in HCC tissue was significantly higher than that in adjacent normal tissue (P < 0.05) and was associated with tumour size, TNM stage and pathological vascular invasion.hsa-circ-0046600 is present mainly in the cytoplasm and promotes the expression of proteins such as HIF-1α by competitively binding to miR-640 in HCC, thereby affecting the malignant biological behaviour of liver cancer cells. The expression level of hsa-circ-0046600 in HCC tissue was significantly higher than that in adjacent normal tissue (P < 0.05) and was associated with tumour size, TNM stage and pathological vascular invasion. Yes Moreover, the downregulated expression of hsa-circ-0046600 significantly inhibited the migration of HepG2 and SK-HEP-1 cells. 31807009 circPCNX CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[Inhibiting miR-506] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay We observed that circPCNX and Pecanex were significantly upregulated in tumor tissues of patients with HCC and correlated with clinicopathological variables or prognosis of HCC patients. Mechanistic investigations suggested that both circPCNX and Pecanex 3'UTR could bind to miR-506 and subsequently inhibited the miR-506-induced anticarcinogenic effect in HCC. Yes Functional investigations showed circPCNX and Pecanex could promote the viability of HCC cells. 32099459 circHIPK3 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[sponging miR-338-3p to induce ZEB2 expression] qRT-PCR//Luciferase Report Assay//RIP//Western Blot CircHIPK3 expression is significantly upregulated during HCC development.CircHIPK3 plays a regulatory role in metastatic HCC by sponging miR-338-3p to induce ZEB2 expression, thus promoting EMT procession. Yes Overexpression of circHIPK3 promotes cell migration, invasion, and metastases in vitro and in vivo. 33247421 hsa_circ_0085616 CircRNA Homo sapiens Carcinoma, Hepatocellular cell lines Expression[highly expressed] qRT-PCR//Western Blot//Transwell Assay We found that hsa_circ_0085616 was highly expressed in all HCC cell lines compared to the normal liver cell line. Moreover, the protein levels of β-catenin, p-ERK, and p-AKT, which play important roles in the typical proliferation pathway, were also affected by the expression of hsa_circ_0085616. Yes Upregulation or downregulation of hsa_circ_0085616 expression could strengthen or weaken the proliferative ability of HCC cells in vitro. 31496798 hsa_circ_0008450 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor and corresponding nontumor tissue Interaction[sponging miR-548p] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of circ_0008450 is Expression[Expression[up-expression]-expression]regulated in HCC tissue specimens and cell lines.In addition, circ_0008450 was proved to be a sponge of miR-548p. The oncogenic role of circ_0008450 was partially attributed to its sExpression[Expression[up-expression]-expression]pression on miR-548p. Patients with a high circ_0008450 expression usually bear a lower 5-year survival rate. Yes Silencing of circ_0008450 in Huh-7 cells inhibited cell viability, migration, and invasion, whereas cell apoptosis was increased. Conversely, its overexpression in HepG2 cells leads to absolutely inverse results. 30556306 circADD3 CircRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues Interaction[EZH2] Co-IP//qRT-PCR//RIP//Microarray//ChIP Here, we performed circRNA microarray expression profile in four paired HCC and normal tissues, and found that circ-ADD3, a novel circRNA derived from linear ADD3 exon 4 to exon 12, was significantly Expression[down-expression]regulated in HCC, which was further validated in 112 matched HCC and paracancerous tissues. Mechanistically, circ-ADD3 was capable of reinforcing the interaction between CDK1 and EZH2, resulting in increased EZH2 ubiquitination and subsequent degradation via phosphorylation at Thr-345 and Thr-487 sites. The decreased EZH2 markedly increased the expression of a cohort of anti-metastatic genes, including circ-ADD3, by reducing H3K27me3 levels on their promoter regions, which formed a regulatory circuit, thereby dampening HCC metastasis. As shown in Table 1, patients with metastatic characteristics exhibited lower circ-ADD3 expression than patients without metastatic characteristics. Moreover, low circ-ADD3 expression was positively correlated with worse overall and progression-free survival (Figure 2C, ​,2D).2D). Yes Functionally, exogenous expression of circ-ADD3 dramatically weakened HCC cell invasion and metastasis both in vitro and in vivo. 31497351 hsa_circ_101280 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues Interaction[regulating miR-375/JAK2] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Western Blot After screening differentially expressed circRNAs in HCC tissues through Gene Expression Omnibus data analysis, hsa_circ_101280 was found to be highly expressed, and its high expression was verified in HCC cell lines with qRT-PCR along with the low expression of its downstream miRNA miR-375. JAK2 was identified as a downstream mRNA target of miR-375 by RNA pull-down and dual-luciferase reporter gene assays, its expression in HCC cell lines were positively regulated by hsa_circ_101280 and negatively by miR-375 expression. Yes Colony formation and flow cytometry assays showed that both hsa_circ_101280 silencing and miR-375 overexpression restrained proliferation and promoted apoptosis in HCC cells. Furthermore, the silencing of hsa_circ_101280 significantly inhibited the growth of HCC xenografts in nude mice, with the downregulated expression of JAK2. Overall, both the in vitro and in vivo studies revealed that hsa_circ_101280 largely facilitated the tumorigenesis of HCC, characterized by the promoted proliferation and suppressed apoptosis of HCC cells, by sponging miR-375 and upregulating JAK2. 30302825 circSETD3 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[microRNA-421] qRT-PCR//Luciferase Report Assay//RNA-seq//RIP CircSETD3 (hsa_circRNA_0000567/hsa_circRNA_101436) was significantly downregulated in HCC tissues and cell lines.rthermore, we demonstrated that circSETD3 acts as a sponge for miR-421 and verified that mitogen-activated protein kinase (MAPK)14 is a novel target of miR-421. Low expression of circSETD3 in HCC tissues significantly predicted an unfavourable prognosis and was correlated with larger tumour size and poor differentiation of HCC in patients. Yes In vitro experiments showed that circSETD3 inhibited the proliferation of HCC cells and induced G1/S arrest in HCC cells. In vivo studies revealed that circSETD3 was stably overexpressed in a xenograft mouse model and inhibited the growth of HCC. 30795787 hsa_circ_103809 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[regulating miR-377-3p/FGFR1/ERK axis] qRT-PCR Our results suggested that hsa_circRNA_103809 was overexpressed in HCC patients.The investigations of molecular showed that hsa_circRNA_103809 could elevate the protein expression of a miR-377-3p target, fibroblast growth factor receptor 1 (FGFR1), through interacting with miR-377-3p and decreasing its expression level. Additionally, in vivo assays revealed hsa_circRNA_103809 short hairpin RNA served as a tumor suppressor through downregulating FGFR1 in HCC. This study systematically investigated novel regulatory signaling of hsa_circRNA_103809/miR-377-3p/FGFR1 axis, providing insights into hepatocellular carcinoma treatment from bench to clinic. Yes hsa_circRNA_103809 knockdown remarkably inhibited the proliferation, cycle progression, and migration of HCC cells. 31317555 circBIRC6 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue,cell lines Regulation[miR-3918/Bcl2 axis] Western Blot//CCK8//FISH//Flow Cytometry//RIP//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that circ-baculoviral IAP repeat-containing (BIRC)6 was upregulated in HCC tissue samples and cells; this was associated with the overall survival of HCC patients.Additionally, circ-BIRC6 overexpression negatively regulated the expression of microRNA miR-3918, which was identified as an inhibitor of B cell lymphoma (Bcl)2. The tumor-suppressive effect of circ-BIRC6 deletion was abrogated by inhibiting miR-3918. Yes circ-BIRC6 knockdown reduced HCC cell proliferation, migration, and invasion and enhanced their apoptosis. 30931701 hsa_circ_0008450 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells lines Regulation[microRNA-214-3p/EZH2 Axis ] CCK8//qRT-PCR//Wound Healing Assay//Luciferase Report Assay hsa_circ_0008450 was significantly increased in HCC tissues and cells. Mechanically, hsa_circ_0008450 promoted the expression of EZH2 protein through sponging miR-214-3p. Knockdown of circ_0008450 suppressed tumorigenesis of HCC cells in vivo. Yes Furthermore, knockdown of hsa_circ_0008450 in HCC cells inhibited cell proliferation, invasion, and migration. 31695501 hsa_circ_0001955 CircRNA Homo sapiens Carcinoma, Hepatocellular HCCtissues Interaction[sponging miR-516a-5p] RNA Pull-Down//Western Blot//qRT-PCR//MTT//Colony Formation Assay We revealed that circ_0001955, TRAF6 and MAPK11 levels were increased, while miR-516a-5p levels were decreased in HCC tumor tissues compared to adjacent normal tissues.Circ_0001955 was identified as a sponge for miR-145-5p and miR-516a-5p, and TRAF6 and MAPK11 were demonstrated to be two target genes of miR-516a-5p. In conclusion, circ_0001955 facilitated HCC tumorigenesis by sponging miR-516a-5p to release TRAF6 and MAPK11 expression. Yes Knockdown of circ_0001955 repressed HCC tumor growth in vitro and in vivo, while overexpression of circ_0001955 exhibited the opposite effect. 31822654 hsa_circ_0000267 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction[sponging miR-646] Flow Cytometry//qRT-PCR//CCK8//Colony Formation Assay//Transwell Assay As a result, circ_0000267 was enhanced in HCC tissues and cell lines.Mechanistically, circ_0000267 could directly sponge miR-646 to exert its oncogenic properties. In summary, we identified a novel HCC-associated circRNA in the progression of this fatal disease. This upregulation is associated with patients' clinical severity and poor prognosis. Yes Functionally, circ_0000267 could facilitate cell growth, migration and invasion and attenuate cell apoptosis in HCC cells. 30719761 circHIAT1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[miR-3171/PTEN axis] qRT-PCR//FISH CircHIAT1 was expressed at a significantly low level in cancerous samples.Mechanistically, circHIAT1 acted as the miR-3171 sponge to upregulate PTEN in HCC. Finally, rescue assays demonstrated the role of circHIAT1/miR-3171/PTEN pathway in regulating HCC cell growth. Taken together, this study revealed the novel mechanism of circHIAT1 in HCC. Based on Kaplan-Meier survival analysis, we determined a positive correlation between the downregulation of circHIAT1 and the poor overall survival of HCC patients. Yes Both in vitro and in vivo experiments demonstrated the suppressive effect of circHIAT1 on the HCC cell growth. 31108351 hsa_circ_0078710 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue,cell lines Interaction[sponging microRNA-31] qRT-PCR Has_circ_0078710 was significantly unregulated in HCC tissues and cells.Furthermore, overexpression of has_circ_0078710 in HCC could up-regulate HDAC and CDK2 levels by sponging miR-31, simultaneously mediating the expression of cell cycle components (cyclin A, cyclin D1, CDK4) and negative cell cycle regulator p21. Moreover, HCC patients with high level of has_circ_0078710 had the advance stage (TNM III-IV). Yes In vitro and in vivo functional studies showed that overexpression of has_circ_0078710 in HepG2, SMMC-7721 cell lines significantly promoted cell proliferation, migration, invasion and tumor growth by inducing the cell cycle progression. 30342168 circDB CircRNA Homo sapiens Carcinoma, Hepatocellular blood Regulation[USP7/Cyclin A2 signaling pathway] Western Blot//qRT-PCR//Luciferase Report Assay//IHC//EdU Staining//IF It was observed that exosome circ-deubiquitination (circ-DB) is upregulated in HCC patients with higher body fat ratios.Moreover, in vitro and in vivo studies showed that exo-circ-DB promotes HCC growth and reduces DNA damage via the suppression of miR-34a and the activation of deubiquitination-related USP7. Finally, the results showed that the effects of adipose exosomes on HCC cells can be reversed by knockdown of circ-DB. These results indicate that exosome circRNAs secreted from adipocytes promote tumor growth and reduce DNA damage by suppressing miR-34a and activating the USP7/Cyclin A2 signaling pathway. Yes Moreover, in vitro and in vivo studies showed that exo-circ-DB promotes HCC growth and reduces DNA damage via the suppression of miR-34a and the activation of deubiquitination-related USP7. 30546088 hsa_circ_0002124 CircRNA Homo sapiens Carcinoma, Hepatocellular liver cancer tissues,cell lines Interaction[MAPK pathway] Flow Cytometry//qRT-PCR//Western Blot//Transwell Assay Hsa_circ_0002124 was highly expressed in the HCC cells and liver cancer tissues. KEGG and interaction network analysis of hsa_circ_0002124 indicated that hsa_circ_0002124 could be a molecular sponge of miRNAs, which regulates the key protein expressions in the MAPK pathway. The p-JNK/JNK, p-ERK/ERK, p-P38/P38, and c-Myc expressions in knockdown hsa_circ_0002124-treated 97H cells were significantly lower than in normal 97H cells, whereas these expressions in overexpressed hsa_circ_0002124-treated 97H cells were significantly higher than in mock vector-treated 97H cells. Yes Moreover, the knockdown hsa_circ_0002124 in 97H cells resulted in the repression of cell proliferation, cell invasion, and migration, with simultaneous promotion of cell apoptosis and cell cycle transformation.The opposing situations of cell function could be detected in overexpressed hsa_circ_0002124 in 97H cells. 35116769 circPTGR1 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Interaction[miR449a-MET pathway] qRT-PCR//Western Blot LM3 exosomes enhanced the cell migration and invasion potential of HepG2 and 97 L cells. CircPTGR1, a circRNA with three isoforms, was specifically expressed in exosomes from 97 L and LM3 cells, upregulated in serum exosomes from HCC patients and was associated with the clinical stage and prognosis. Bioinformatics, co-expression analysis, and a luciferase assay indicated that circPTGR1 competed with MET to target miR449a. Yes Knockdown of circPTGR1 expression suppressed the migration and invasion of HepG2 and 97L cells induced by co-culturing with LM3 exosomes. 30630697 circSMARCA5 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR The expression of circSMARCA5 was significantly downregulated in HCC tissues compared with para-carcinoma tissues. CircSMARCA5 levels were correlated with tumor differentiation (p = 0.023), Tumor-node-metastasis (TNM) stage (p = 0.001), cancer invasion (p = 0.004), as well as cancer diameter (p = 0.018). Yes In vitro cell experiments revealed that overexpression of circSMARCA5 resulted in inhibited proliferation, increased apoptosis and suppressed invasion. 30716279 hsa_circ_0070269 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation[miR-182/NPTX1 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In the present study, we identified a novel circRNA (hsa_circ_0070269) was significantly decreased in HCC tissues and cell lines. Mechanistically, hsa_circ_0070269 increased NPTX1 expression via sponging miR-182 in HCC cells, which inhibited aggressive tumor behavior. Taken together, our findings suggest that hsa_circ_0070269 might play an important role in HCC development via miR-182/NPTX1 axis, therefore could serve as a potential therapeutic target for HCC treatment. low hsa_circ_0070269 expression was positively associated with advanced tumor stage, lymph node metastasis, and poor overall survival. Yes Hsa_circ_0070269 overexpression suppressed proliferation and invasion of HCC cells in vitro and reduced tumor growth in vivo. 31606623 hsa_circ_0000502 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[targeting microRNA-124] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay QRT-PCR results indicated that the level of circ_0000502 in HCC tissues was significantly higher than that in adjacent ones. QRT-PCR results revealed that the expression of miR-124 and circ_0000502 mRNA in HCC tissues was negatively correlated. Also, the result of luciferase reporter gene assay demonstrated that circ_0000502 could be targeted by miR-124 via this binding site.  Compared with patients with low expression of circ_0000502, patients with high expression of circ_0000502 had a lower overall survival rate compared with the negative control (NC) group. Yes The proliferation, invasion and migration ability of circ_0000502 knockdown group significantly decreased, while on the contrary cell apoptosis increased. 31983112 hsa_circ_100338 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[circRNA-100338/miR-141-3p/RHEB axis ] CCK8//qRT-PCR//IHC//Western Blot The circRNA expression profiles based on the RNA-seq data indicated that circRNA-100338 was significantly up-regulated in tumor tissues, as compared with non-tumor tissues (P-value < 0.001, Figure 1A). In conclusion, elevated circRNA-100338 activates mTOR signaling pathway in HCC via circRNA-100338/miR-141-3p/RHEB axis and associates with poor prognosis of hepatitis B-related HCC patients. Yes Cell proliferation assay demonstrated that knockdown of circRNA-100338 in highly metastatic potential HCC cell lines could significantly reduce the cancer cell proliferation (Figure 1B). Consistently, overexpression of circRNA-100338 in two HCC cell lines with low metastatic potential could increase cancer cell proliferation (P < 0.05, Figure 1C). 31157168 hsa_circ_0021093 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Regulation[miR-766-3p/MTA3 axis] qRT-PCR Upregulation of circ_0021093 was found in HCC tumor samples and cells. In conclusion, the circ_0021093/miR-766-3p/MTA3 regulatory axis may be an effective therapeutic target for HCC. Yes Furthermore, downregulated circ_0021093 attenuated cell growth, migration and invasion but increased cell apoptosis. 31330234 circGSK3B CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and HCC cell lines regulation[circGSK3B-miR-1265-CAB39 axis] qRT-PCR//RNA Pull-Down//RIP We found that circGSK3B was highly expressed in HCC tissues and HCC cell lines.In summary, we proved that the circGSK3B-miR-1265-CAB39 axis can promote the proliferation, migration, invasion of HCC cells, indicating that circGSKB may serve as a promising diagnostic and prognostic marker in HCC. Additionally, the expression level of circGSK3B significantly correlated with HCC tumor size and vascular invasion. Yes Functionally, we confirmed that circGSK3B can promote the proliferation, migration, and invasion of HCC cells in vivo and in vitro. 33262952 circSOD2 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues regulation[JAK2/STAT3 signaling pathway] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay In accordance with previous sequencing results, here, we demonstrated that circSOD2 was highly expressed in HCC tumor tissues compared with normal liver tissues. The novel signaling axis circSOD2/miR-502-5p/DNMT3a/JAK2/STAT3/circSOD2 provides a better understanding of HCC tumorigenesis. Yes SiRNA mediated circSOD2 suppression impaired liver cancer cell growth, cell migration, prohibited cell cycle progression and in vivo tumor growth. 33234142 circE2F2 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cell line Interaction(HuR/E2F2) qRT-PCR//RIP//Western Blot The results showed that one of the circRNAs (termed circE2F2) was significantly upregulated in OC tissues and cell lines, and high circE2F2 expression was associated with poor survival in OC patients. In circE2F2-deficient cells, the half-life of the E2F2 mRNA was significantly shorter than that in the control group, indicating that sufficient circE2F2 expression could strengthen the stability of the E2F2 mRNA. Further analysis revealed that circE2F2 could bind to RNA-binding protein Hu antigen R (HuR). The results showed that one of the circRNAs (termed circE2F2) was significantly upregulated in OC tissues and cell lines, and high circE2F2 expression was associated with poor survival in OC patients. Yes The knockdown of circE2F2 in OC cells suppressed cell proliferation, migration, invasion, and cellular glucose metabolism. 33894314 hsa_circ_0001445 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-942-5p/ALX4 axis] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay Herein, circ_0001445 was decreased and miR-942-5p was increased in HCC tissues and cells. In conclusion, circ_0001445 played a negative role in HCC progression by modulating miR-942-5p/ALX4 axis, which might provide a novel target for HCC therapy. Yes Circ_0001445 overexpression or miR-942-5p inhibition repressed cell cycle process, migration, invasion, epithelial-mesenchymal transition and glycolysis in HCC cells. 32856218 hsa_circ_0046599 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-1258/RPN2 Network] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Circ_0046599 was highly expressed in HCC tissues and cells, and its knockdown could suppress HCC cell proliferation, migration, invasion and glycolysis process.Our results provided new evidence that circ_0046599 could promote the progression of HCC by increasing RPN2 expression via sponging miR-1258. Yes Circ_0046599 was highly expressed in HCC tissues and cells, and its knockdown could suppress HCC cell proliferation, migration, invasion and glycolysis process. 32801909 hsa_circ_101141 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-1297/ROCK1 Pathway] Western Blot//ISH//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay In the present study, we found that the expression of human circ_101141 was upregulated in HCC tissues and cells.aken together, these findings indicated that circRNA circ_101141 acted as a ceRNA to facilitate tumorigenesis of HCC by regulating miR-1297/ROCK1 pathway. Yes In addition, downregulation of circ_101141 dramatically inhibited cell proliferation, migration, and invasion in HCC cells. 32787581 hsa_circ_0000517 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-326/SMAD6 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Colony Formation Assay//Transwell Assay Hsa_circ_0000517 and SMAD6 were up-regulated while miR-326 was down-regulated in HCC tissues and cells. Hsa_circ_0000517 depletion repressed HCC advancement via regulating the miR-326/SMAD6 axis. Yes Hsa_circ_0000517 down-regulation repressed cell proliferation, colony formation, migration, and invasion, and induced cell cycle arrest in HCC cells in vitro, and constrained tumor growth in vivo. 32774154 hsa_circ_4911 CircRNA Homo sapiens Carcinoma, Hepatocellular human umbilical vein endothelial cells Expression[lower expressed] qRT-PCR//RNA-seq Subsequently, we validated the expression of the candidate circRNAs using RT?qPCR, and selected two of the most downregulated circRNAs among them, circ_4911 and circ_4302. Yes Next, through circRNA overexpression experiments, we demonstrated that overexpression of circ_4911 and circ_4302 both inhibited the proliferation and migration of HUVECs, and arrested cells at the GO/G1 stage, while promoting adhesion. 32700752 hsa_circ_4302 CircRNA Homo sapiens Carcinoma, Hepatocellular human umbilical vein endothelial cells Expression[lower expressed] qRT-PCR//RNA-seq Subsequently, we validated the expression of the candidate circRNAs using RT?qPCR, and selected two of the most downregulated circRNAs among them, circ_4911 and circ_4302. Yes Next, through circRNA overexpression experiments, we demonstrated that overexpression of circ_4911 and circ_4302 both inhibited the proliferation and migration of HUVECs, and arrested cells at the GO/G1 stage, while promoting adhesion. 32700752 hsa_circ_103809 CircRNA Homo sapiens Carcinoma, Hepatocellular cell lines regulation[circRNA-103809/miR-1270/PLAGL2 axis] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay CircRNA-103809 was highly expressed in HCC cell lines.Thereafter, we verified the tumor-facilitating effect of circRNA-103809/miR-1270/PLAGL2 axis on biological behaviors of HCC cells. Yes After interfering circRNA-103809, the proliferation, migration, invasion and epithelial-to-mesenchymal transition process were all hindered in HCC cells. 32683589 hsa_circ_0091579 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-490-5p/CASC3 Axis] qRT-PCR//Luciferase Report Assay//Western Blot//Transwell Assay circ_0091579 and CASC3 were upregulated, while miR-490-5p was downregulated in HCC tissues and cells.circ_0091579 promoted cell proliferation, migration, invasion, and glycolysis partially through miR-490-5p/CASC3 axis in HCC cells. Yes Silencing of either circ_0091579 or CASC3 suppressed cell proliferation, migration, invasion, and glycolysis in HCC cells. 32673066 circNFATC3 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-548I,NFATC3 ] qRT-PCR//Transwell Assay Overall, the circNFATC3 can sponge miR-548I to protect NFATC3 itself, then it regulates hepatoma cell function via the JNK, c-Jun, AKT, and mTOR signaling pathways, and the circNFATC3 can be a tumor-repressor on HCC. Yes 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, apoptotic, and transwell assay proved that circNFATC3 can inhibit hepatoma cell proliferation, apoptosis, and migration/invasion in vitro. Mouse xenograft assay demonstrated that circNFATC3 suppressed tumor size and weight and reduced lung metastasis in vivo, and vice versa. 32667692 circKIAA1429 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tumor tissues regulation[m6A-YTHDF3-Zeb1] qRT-PCR In this study, we found hsa_circ_0084922, which came from KIAA1429, named circ_KIAA1429, was upregulated in HCC cells and tumor tissues. This study revealed that circ_KIAA1429 could accelerate HCC advancement, maintained the expression of Zeb1 through the mechanism of m6A-YTHDF3-Zeb1 in HCC. Yes Overexpression of circ_KIAA1429 can facilitate HCC migration, invasion, and EMT process. However, knockdown of circ_KIAA1429 lead to the opposite results. 32653519 hsa_circ_0026134 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC samples and cell lines regulation[miR-127-5p expression] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay hsa_circ_0026134 expression was increased in HCC samples and cell lines.Down-regulation of hsa_circ_0026134 suppressed TRIM25- and IGF2BP3-mediated HCC cell proliferation and invasion via promotion of miR-127-5p expression, which have been confirmed by luciferase reporter assay. Yes Down-regulation of hsa_circ_0026134 attenuated HCC cell proliferation and metastatic properties. 32648571 hsa_circ_0005394 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-507/E2F3 and miR-515-5p/CXCL6 Signaling Pathways] qRT-PCR//Luciferase Report Assay circ_0005394 expression was higher in HCC tissues and cells than noncancerous samples and normal cell line, respectively.Rescue assay indicated that circ_0005394 facilitated HCC growth and invasion by regulating miR-507/E2F3 and miR-515-5p/CXCL6 signaling pathways. High expression of circ_0005394 was associated with larger tumor size, more advanced TNM stages, and poorer overall survival for the patients with HCC. Yes Gain/loss-of function assays demonstrated its oncogenic role in cell growth, apoptosis, migration, and invasion. 32636641 circPTN CircRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tumor tissues and cell lines interaction[ Sponges miR-326] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//EdU Staining Our results indicated that circPTN was upregulated in human hepatocellular carcinoma tumor tissues and cell lines, compared with paratumor tissues and immortalized normal liver cell line.Our study indicates that circPTN acts as an oncogenic factor via sponging miR-326 in HCC. Yes circPTN could significantly promote HCC tumor growth according to gain-and loss-of-function assays. 32581550 hsa_circ_0000515 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[regulating MAPK10] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Circ_0000515 was highly expressed in HCC tissues and cell lines. Circ_0000515 aggravates the malignant progression of HCC by downregulating MAPK10. High level of circ_0000515 predicted advanced stage, high incidence of lymphatic metastasis, and low disease-free survival and overall survival in HCC. Yes Knockdown of circ_0000515 attenuated proliferative and migratory abilities in Hep3B and MHCC88H cells. 32572915 hsa_circ_0101145 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-548c-3p/LAMC2 axis] RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay//Transwell Assay The data demonstrated that hsa_circ_0101145 was significantly upregulated in both HCC tissues and cell lines. . In summary, the findings illustrated that hsa_circ_0101145 silencing suppressed HCC progression by functioning as an miR-548c-3p sponge to enhance LAMC2 expression. Yes Downregulation of hsa_circ_0101145 suppressed HCC proliferation as well as metastasis by targeting the miR-548c-3p/LAMC2 axis, which was examined using luciferase reporter and RNA pulldown assays. Silencing of hsa_circ_0101145 suppressed the epithelial-mesenchymal transition in HCC. 32554866 hsa_circ_0003998 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[ circ0003998/miR-143-3p/FOSL2 axis and circ0003998 /PCBP1/CD44v6 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Compared with adjacent normal liver tissues (ANL), circ0003998 expression was significantly upregulated in PVTT tissues and HCC tissues, and its expression correlates with the aggressive characteristics of HCC patients.Circ0003998 promotes EMT of HCC by circ0003998/miR-143-3p/FOSL2 axis and circ0003998 /PCBP1/CD44v6 axis. Yes Further assays suggested that circ0003998 promoted EMT of HCC both in vitro and in vivo. 32552766 circMTO1 CircRNA Homo sapiens Carcinoma, Hepatocellular liver cancer tissues and cell lines regulation[miR-9-5p/NOX4 Axis] CCK8//qRT-PCR//Transwell Assay//Western Blot CircMTO1 were down-regulated in the liver cancer tissues and cell lines compared to their respective normal controls. Yes Overexpression of circMTO1 and NOX4 inhibited proliferation and migration of hepatoma cells, while the overexpression of miR-9-5p had the opposite effects. In contrast, overexpression of circMTO1 and NOX4 promoted apoptosis, while that of miR-9-5p decreased the cell apoptosis rates. 32547227 circGprc5a CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues or cells regulation[YAP1/TEAD1 signaling pathway] CCK8//qRT-PCR//Western Blot CircGprc5a was highly expressed in liver cancer, and closely related poor survival of patients with liver cancer. CircGprc5a promoted the development of HCC by inhibiting the expression of miR-1283 and activating the YAP1/TEAD1 signaling pathway. CircGprc5a was highly expressed in liver cancer, and closely related poor survival of patients with liver cancer. Yes Knockout of circGprc5a inhibited proliferation of HCC and induced apoptosis. 32547082 circZNF566 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[ circZNF566/ miR-4738-3p /TDO2 axis] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//RIP//Colony Formation Assay//Transwell Assay CircZNF566 was significantly upregulated in HCC tissues and cell lines. High circZNF566 expression in HCC tissues was positively correlated with clinicopathological features and poor prognosis. Yes Functionally, in vitro experiments showed that circZNF566 promoted HCC cell migration, invasion, and proliferation, whereas in vivo experiments showed that circZNF566 promoted tumorigenesis and metastasis. 32532962 circCSPP1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues interaction[sponging miR-577] ISH//Wound Healing Assay//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In HCC patients and cells, circ-CSPP1 was aberrantly expressed, and its upregulation predicted poor prognosis, and closely correlated with tumor size and TNM stage.These findings revealed that circ-CSPP1 contributed to HCC progression by positively regulating CCNE2 via miR-577, thus established its potential as new a prognostic and therapeutic marker for HCC patients. In HCC patients and cells, circ-CSPP1 was aberrantly expressed, and its upregulation predicted poor prognosis, and closely correlated with tumor size and TNM stage. Yes Moreover, overexpression of circ-CSPP1 promoted HCC cell viability, colony formation, migration, and invasion in vitro. Knockdown of circ-CSPP1 showed contrary results. 32514247 circIL4R CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-541-3p/GPX4 network] RNA Pull-Down//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay CircIL4R was abnormally overexpressed in HCC tissues and cells. Our data suggested that circIL4R served for a tumor promoter and ferroptosis inhibitor in HCC by the miR-541-3p/GPX4 network. Yes CircIL4R knockdown impeded oncogenesis and expedited ferroptosis of HCC cells. 32808701 hsa_circ_0000517 CircRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues and cell lines regulation[miR-326/IGF1R axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay  circ_0000517 expression was elevated in hepatocellular carcinoma tissues and cell lines. circ_0000517 knockdown repressed hepatocellular carcinoma development in vitro and in vivo by modulating miR-326 and IGF1R. Yes  circ_0000517 knockdown suppressed cell viability, colony formation, migration, invasion and glycolysis. 32863763 hsa_circ_0001955 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues regulation[miR-145-5p/NRAS Axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Microarray//Transwell Assay hsa_circ_0001955 ranked as the top three most upregulated DECs in GEO: GSE78520, GSE94508, and GSE97332. Collectively, our findings demonstrate the oncogenic roles of the hsa_circ_0001955/miR-145-5p/NRAS axis in HCC, which may represent a potential therapeutic target for HCC. Moreover, hsa_circ_0001955 expression in HCC cells and tissues was significantly higher than that in corresponding normal controls. Yes Functional experiments revealed that knockdown of hsa_circ_0001955 markedly inhibited proliferation, migration, and invasion of HCC, and its overexpression led to the opposite effects. 33230448 circMYLK CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR29a/KMT5C Signaling Pathway] qRT-PCR//Luciferase Report Assay//Western Blot//FISH circMYLK was determined to be significantly upregulated in HCC tissues and cells.Our current study demonstrated that circMYLK promotes HCC progression by acting as a competing endogenous RNA of miR-29a, which regulates the downstream oncogene KMT5C. Yes Suppression of circMYLK repressed HCC cell proliferation, migration, and invasion while increasing apoptosis. 32904604 circTMEM45A CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[MicroRNA-665 ] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray We found that the level of circTMEM45A was significantly upregulated in HCC and was positively correlated with clinicopathological features and poor prognosis of patients with HCC.Mechanistically, circTMEM45A acted as a miR-65 sponge to relieve the repressive effect of miR-665 on its target IGF2. We found that the level of circTMEM45A was significantly upregulated in HCC and was positively correlated with clinicopathological features and poor prognosis of patients with HCC. Yes Functionally, circTMEM45A promoted cell mobility in vitro, as well as in vivo tumorigenesis. 33230434 circLRIG3 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[EZH2/STAT3 signaling] ChIP//Co-IP//CCK8//qRT-PCR//RIP//EdU Staining//Transwell Assay Circ-LRIG3 was notably upregulated in HCC and promoted HCC cell proliferation, migration, invasion and reduced apoptosis. Circ-LRIG3 formed a ternary complex with EZH2 and STAT3, facilitating EZH2-induced STAT3 methylation and subsequent phosphorylation, resulting in the activation of STAT3 signaling. Clinically, high circ-LRIG3 was closely linked with aggressive clinicopathological features and was identified as an independent risk prognostic factor of overall survival. Yes Circ-LRIG3 was notably upregulated in HCC and promoted HCC cell proliferation, migration, invasion and reduced apoptosis. The animal models showed that exogenous expression of circ-LRIG3 enhanced tumorigenicity and metastasis in vivo, whereas these effects were blocked after treatment with C188-9, a specific STAT3 small-molecule inhibitor. 33222697 hsa_circ_0008305 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines interaction[binding to miR-186 and inducing TMED2] RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Currently, our data showed that circ_0008305 was highly elevated in HCC cell lines and 30 paired tissue samples of HCC. Mechanistically, we demonstrated that circ_0008305 up-regulated TMED2 expression by sponging miR-186, which resulted in significantly induced HCC progression in vitro and in vivo. Yes As evidenced, suppression of circ_0008305 repressed HCC cell growth significantly. Meanwhile, up-regulation of circ_0008305 significantly reduced HCC cell growth. 33210454 circFAT1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-30a-5p/REEP3 pathway] Western Blot//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Transwell Assay In the present study, we found that circFAT1 expression is up-regulated in HCC tissues and cells.In conclusion, circFAT1 sponges miR-30a-5p to regulate the expression of REEP3, thus promoting hepatocarcinogenesis. In addition, circFAT1 level is positively correlated with TNM stage and tumour size. Yes The results show that circFAT1 inhibition reduces the proliferation and invasion of HCC cells and tumorigenesis in vivo, whereas REEP3 overexpression reverses these processes. 33179443 hsa_circ_1306 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-584-5p/CDK16 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay we found has_circRNA_001306 (circ_1306) was up-regulated in HCC tissues and cell lines.Altogether, our findings suggested that circ_1306 could promoter HCC progress by miR-584-5p/CDK16 axis, which provided a novel marker for HCC diagnosis and treatment. Yes Knockdown the expression circ_1306 significantly suppressed HCC cell proliferation and induced the cell apoptosis in vitro and in vivo. 33135290 hsa_circ_0039053 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines interaction[combining with miR-637] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Herein, hsa_circ_0039053 was upregulated in HCC tissues and cell lines. Collectively, our study confirmed that hsa_circ_0039053 could be regarded as a competing endogenous RNA (ceRNA) to positively modulate the expression of USP21 combining with miR-637, which provided a potential target in HCC treatment. Yes Downregulation of hsa_circ_0039053 decreased the invasion and proliferative ability of tumors in vitro and as well as tumor growth in vivo. 33123285 hsa_circ_102559 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-130a-5p,ANXA2] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay First, analysis of HCC-related circRNA expression profile GSE97332 and HCC patients showed a significant upregulation of hsa_circ_102559 in HCC tissues. Upregulation of hsa_circ_102559 in HCC cells was associated with the metastatic properties. Yes Second, hsa_circ_102559 significantly promoted HCC metastasis, while knockdown of hsa_circ_102559 reversed the promotive effects on HCC progression. Lastly, xenograft experiment was established and results indicated that knockdown of hsa_circ_102559 inhibited HCC growth and metastasis through the downregulation of ANXA2. 33121269 circUGGT2 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-526b-5p/RAB1A Axis] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay We observed that circUGGT2 and RAB1A were upregulated while miR-526b-5p was downregulated in HCC tissues and cells. CircUGGT2 silencing inhibited HCC development via modulating the miR-526b-5p/RAB1A axis, providing a possible target for HCC treatment. Yes CircUGGT2 silencing suppressed tumor growth in vivo and curbed proliferation, colony formation, cell cycle progression, migration, and invasion of HCC cells in vitro. 33116877 circCDR1as CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-1287/Raf1 and MEK/ERK pathways] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Expression of circ_CDR1as and Raf1 is elevated, while miR-1287 expression is decreased in HCC. Circ_CDR1as depletion inhibits HCC cell proliferation and metastasis by miR-1287/Raf1 and MEK/ERK pathways, highlighting a promising molecular target for HCC treatment. Yes Depletion of circ_CDR1as or Raf1 could inhibit proliferation and metastasis of HCC cells. 33061591 hsa_circ_0004018 CircRNA Homo sapiens Carcinoma, Hepatocellular tumor tissues,cell lines regulation[hsa_circ_0004018/miR-626/DKK3 regulatory axis] RNA Pull-Down//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay We found that the expression of hsa_circ_0004018 was lower in tumor tissues than in their paired non-tumor tissues from 28 out of 41 HCC patients.Similarly, hsa_circ_0004018 was downregulated in HCC cell lines. We revealed that hsa_circ_0004018/miR-626/DKK3 regulatory axis may be a possible novel therapeutic target for HCC. The difference in the expression between tumor tissues and non-tumor tissues was statistically significant (p<0.001). Further analysis revealed that such lower expression in tumor tissues was much more common in bigger tumor size group (≥5cm) compared with the smaller tumor size group (<5cm) (85% vs 42%, p=0.0007). Yes Furthermore, hsa_circ_0004018 blocked xenograft tumor growth in vivo through inhibiting Wnt/β-catenin signaling pathway by targeting miR-626/DKK3. 33061423 hsa_circ_0091581 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue samples and cell lines regulation[miR-591/FOSL2 Axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0091581 was highly expressed in HCC tissue samples and cell lines in contrast to that in adjacent normal tissue samples and THLE-2 cell line. Circ_0091581 acted as an oncogene to enhance the viability, colony formation, metastasis and cell cycle and inhibit the apoptosis of HCC cells through targeting miR-591/FOSL2 axis. Yes Circ_0091581 accelerated the viability, colony formation, metastasis, and cell cycle, while it impeded the apoptosis of HCC cells. Circ_0091581 interference notably suppressed HCC tumor growth in vivo. 33040214 hsa_circ_102 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines interaction[as a sponge of miR-182 and miR-184] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining//Transwell Assay We found that a novel circular RNA, circ-102,166, was down-regulated in HCC and that its expression level was significantly associated with multiple clinicopathologic characteristics, as well as the clinical prognosis of HCC patients. Down-regulation of circ-102,166 enhanced the proliferation and invasion of HCC cells by releasing the oncomiRs miR-182 and miR-184. We found that a novel circular RNA, circ-102,166, was down-regulated in HCC and that its expression level was significantly associated with multiple clinicopathologic characteristics, as well as the clinical prognosis of HCC patients. Yes In vitro and in vivo experiments revealed that circ-102,166 overexpression significantly inhibited the proliferation, invasion, migration and tumorigenicity of HCC cells. 33034848 hsa_circ_166 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines interaction[as a sponge of miR-182 and miR-184] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining//Transwell Assay We found that a novel circular RNA, circ-102,166, was down-regulated in HCC and that its expression level was significantly associated with multiple clinicopathologic characteristics, as well as the clinical prognosis of HCC patients. Down-regulation of circ-102,166 enhanced the proliferation and invasion of HCC cells by releasing the oncomiRs miR-182 and miR-184. We found that a novel circular RNA, circ-102,166, was down-regulated in HCC and that its expression level was significantly associated with multiple clinicopathologic characteristics, as well as the clinical prognosis of HCC patients. Yes In vitro and in vivo experiments revealed that circ-102,166 overexpression significantly inhibited the proliferation, invasion, migration and tumorigenicity of HCC cells. 33034848 hsa_circ_104566 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues interaction[sponged miR-338-3p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//FISH//Luciferase Report Assay//Transwell Assay First, the high expression of hsa_circ_104566 was found in HCC tissues, which was significantly associated with poor prognosis in HCC patients. In conclusion, hsa_circ_104566 sponged miR-338-3p to promote HCC progression, providing a potential therapeutic target for cancer intervention. First, the high expression of hsa_circ_104566 was found in HCC tissues, which was significantly associated with poor prognosis in HCC patients. Yes Second, Hsa_circ_104566 promoted HCC progression by decreasing apoptosis and E-cadherin, while increasing cell viability, proliferation, migration, invasion, and N-cadherin. On the other hand, HCC progression was suppressed by knockdown of hsa_circ_104566. 33028110 hsa_circ_0004913 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-184/HAMP axis] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Circ_0004913 was downregulated in HCC, and its expression impeded cell proliferation, migration, and invasion, EMT, and glycolysis in HCC cells.Circ_0004913 could inhibit JAK2/STAT3/AKT signaling pathway and tumor growth in vivo by regulating the miR-184/HAMP axis. Yes Circ_0004913 was downregulated in HCC, and its expression impeded cell proliferation, migration, and invasion, EMT, and glycolysis in HCC cells. 33021399 hsa_circ_0038718 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells interaction[sponging miR-139-3p] IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that circ-0038718 was frequently elevated in HCC specimens and cell lines.Rescue experiments suggested the oncogenic activity of circ-0038718 was partially exerted via modulating miR-139-3p expression. Inhibition of miR-139-3p abrogated the regulatory effect of circ-0038718 in HCC cells. High expression levels of circ-0038718 were correlated with unfavorable prognosis in HCC patients. Yes Furthermore, we demonstrated that knockdown of circ-0038718 attenuated HCC cell proliferation and metastatic abilities, while overexpression of circ-0038718 resulted the converse effect. Silencing circ-0038717 inhibited HCC xenograft tumor development in vivo. 33008587 circHIPK3 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-582-3p/DLX2 axis] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Transwell Assay Circ_HIPK3 and DLX2 levels were enhanced, and miR-582-3p level was reduced in HCC tissues and cells. Circ_HIPK3 facilitated HCC progression by mediating miR-582-3p/DLX2 pathway, suggesting a new potential biomarker for HCC treatment. Yes Silencing of circ_HIPK3 impeded proliferation, migration and invasion and expedited apoptosis in HCC cells. 32977948 hsa_circ_0005785 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-578/APRIL Axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay Herein, we explored the functions and potential mechanisms of hsa_circ_0005785 in HCC, which was aberrantly overexpressed in HCC and related to HCC patients' TNM stage and overall survival. Moreover, targeting to the hsa_circ_0005785/miR-578/APRIL regulatory pathway might be a promising diagnostic and therapeutic strategy for HCC clinical practice. Herein, we explored the functions and potential mechanisms of hsa_circ_0005785 in HCC, which was aberrantly overexpressed in HCC and related to HCC patients' TNM stage and overall survival. Yes . Moreover, hsa_circ_0005785 depletion could repress proliferation and metastasis of the HCC cell in vitro, lead to cell apoptosis and cell-cycle arrest, and restrain HCC cell growth in vivo. 32974140 circFBLIM1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC serum exosomes and HCC cells regulation[miR-338/LRP6 Axis] Flow Cytometry//qRT-PCR//MTT ircFBLIM1 was highly expressed in HCC serum exosomes and HCC cells. CircFBLIM1 facilitated HCC progression and glycolysis via modulating the miR-338/LRP6 axis, which may provide promising therapeutic targets for HCC. Yes Inhibition of circFBLIM1 confined HCC glycolysis and progression. CircFBLIM1 knockdown blocked tumorigenesis in vivo. 32907351 circADAMTS13 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[miR-484] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq CircADAMTS13, derived from Exon 13-14 of the ADAMTS13 gene, was significantly Expression[down-expression]regulated in HCC tumor tissues. Bioinformatic analysis and luciferase reporter assays further revealed that circADAMTS13 directly interacts with microRNA (miR)-484. Rescue experiments showed that miR-484 mimics can reverse the tumor-sExpression[Expression[up-expression]-expression]pressing roles of circADAMTS13 in HCC. Yes Furthermore, clinicopathological analysis revealed that Expression[Expression[up-expression]-expression]-regulation of circADAMTS13 was negatively associated with tumor size but positively associated with prognosis. In addition, overexpression of circADAMTS13 could markedly inhibit HCC cell proliferation in vitro. 30537115 circTRIM33 CircRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues,cell line Interaction[MicroRNA-191 ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Here, we found that circTRIM33-12, is Expression[down-expression]regulated in HCC tissues and cell lines. Mechanistically, we demonstrated that circTRIM33-12 Expression[Expression[up-expression]-expression]regulated TET1 expression by sponging miR-191, resulting in significantly reduced 5-hydroxymethylcytosine (5hmC) levels in HCC cells. The Expression[down-expression]regulation of circTRIM33-12 in HCC was significantly correlated with malignant characteristics and served as an independent risk factor for the overall survival (OS) and recurrence-free survival (RFS) of patients with HCC after surgery. Yes The reduced expression of circTRIM33-12 in HCC cells increases tumor proliferation, migration, invasion and immune evasion. 31153371 hsa_circ_0001649 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines(HHCC, H-97, HepG2, HuH-7, Li-7, SMMC-7721, HepG2.2.15 and HL-7702) Interaction[miR-127-5p, miR-612 and miR-4688] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//RNA-seq Results showed that circ-0001649 was markedly decreased in hepatocellular carcinoma cell lines and tumor tissues. More importantly, we confirmed that circ-0001649 regulated cellular behaviors of HCC cells by targeting SHPRH. Furthermore, we determined that circ-0001649 served as a ceRNA to sponge miR-127-5p, miR-612 and miR-4688, thus activating SHPRH. Yes Overexpression of circ-0001649 greatly inhibited proliferation and migration of HCC in vitro and in vivo. 31137016 hsa_circ_0003892 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(miR-326/LASP1 axis) Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay Circ_0003892 expression was raised in PTC tissues and cells, which was significantly interrelated with larger tumor size and extrathyroidal extension in PTC sufferers.Additionally, miR-326 was a downstream target of circ_0003892, and miR-326 overexpression weakened the promoting effect of circ_0003892 overexpression on the malignant progression of PTC. MiR-326 specifically inhibited LASP1. Circ_0003892 positively regulated LASP1 expression by targeting miR-326. Circ_0003892 expression was raised in PTC tissues and cells, which was significantly interrelated with larger tumor size and extrathyroidal extension in PTC sufferers. Yes Overexpression of circ_0003892 significantly promoted the malignant biological behaviors of PTC cells. 36394255 circFAM53B CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(miR-183-5p-CCDC6) qRT-PCR//MTT//Luciferase Report Assay//RIP Our data showed that circ_FAM53B expression was reduced in PTC tissues and cells. Circ_FAM53B repressed miR-183-5p expression. MiR-183-5p re-expression reversed the effects of circ_FAM53B on cell behaviors. MiR-183-5p targeted and inhibited CCDC6, and circ_FAM53B upregulated CCDC6 through miR-183-5p competition. MiR-183-5p knockdown repressed cell proliferation, migration, invasion, and tube formation and facilitated apoptosis by upregulating CCDC6. Furthermore, circ_FAM53B reduced tumor growth in vivo. Collectively, our findings suggest that circ_FAM53B affects PTC cell biological behaviors via the miR-183-5p-CCDC6 axis. Yes Circ_FAM53B expression restrained proliferation, migration, and invasion and triggered apoptosis of PTC cells, as well as hindered HUVEC tube formation. 35598218 hsa_circ_0082003 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Expression(highly expressed) CCK8//qRT-PCR//Wound Healing Assay//Colony Formation Assay RT-qPCR validation demonstrated that hsa_circ_0082003 expression was significantly increased in PTC tissues and correlated with poor clinicopathological parameters. RT-qPCR validation demonstrated that hsa_circ_0082003 expression was significantly increased in PTC tissues and correlated with poor clinicopathological parameters.Receiver operating characteristic curve analysis showed that hsa_circ_0082003 had good performance for diagnosing PTC and judging whether it was accompanied by lymph node metastasis. Yes Knockdown of hsa_circ_0082003 inhibited PTC cell proliferation, migration, and invasion. Tumor formation assays in vivo showed that downregulation of hsa_circ_0082003 significantly suppressed the growth of PTC. 36115894 hsa_circ_0002111 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(miR-363-3p/HMGB1 axis) Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay It was found that the expression of circ_0002111 was enhanced in PTC tissues and cells. For mechanism analysis, circ_0002111 adjusted the expression of HMGB1 by sponge adsorption of miR-363-3p. Moreover, miR-363-3p inhibitor regained the influence of cellular malignant phenotype caused by circ_0002111 knockdown. Additionally, miR-363-3p overexpression impacted the cell functions by targeting HMGB1 in PTC. Yes Silencing circ_0002111 apparently retarded the viability, proliferation, invasion and tube formation, as well as expedited the apoptosis of PTC cells. Besides, circ_0002111 knockdown impeded the growth of the tumor in vivo. 36136992 circNRIP1 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and PTC cell lines Interaction(miR-653-5p/PBX3 axis) RNA Pull-Down//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay circNRIP1 significantly increased in PTC tissues and PTC cell lines than that in normal ones.circNRIP1 was a miR-653-5p sponge; miR-653-5p knockdown reversed the suppressive role of circNRIP1 silence in PTC progression. PBX3, a target of miR-653-5p, was positively medicated through circNRIP1 via competitively sponging miR-653-5p. Higher circNRIP1 expression was associated with the TNM stage and poorer overall survival. Yes circNRIP1 knockdown attenuated the malignant progression of PTC, specifically by inhibiting proliferation and invasion/migration and promoting apoptosis. Knockdown of circNRIP1 attenuated the PTC tumor progression via miR-653-5p/PBX3 axis. 35646117 hsa_circ_000926 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues Interaction[bind to miR-411 to up-regulate CDH2] Western Blot//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay The expression of circ_000926, miR-411, and cadherin 2 (CDH2) was up-regulated or down-regulated in RCC cells to unearth their effects on the biological behaviors of RCC cells.circ_000926 was highly expressed in RCC tissues and cell lines, whereas CDH2 was verified to be a target of miR-411. As a competing endogenous RNA, circ_000926 could directly bind to miR-411 to up-regulate CDH2. Yes Down-regulation of circ_000926 resulted in inhibited growth, migration, and invasion abilities of RCC cells, as well as suppressed epithelial-mesenchymal transition and tumor growth. 31476285 hsa_circ_0039569 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues Interaction[miR-34a-5p/CCL22] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Hsa_circ_0039569 (circ_0039569) was verified to be up-regulated in RCC and cells compared with the controls by real time RT-PCR.The molecular mechanism of circ_0039569 in RCC cells showed that circ_0039569 promoted RCC progression by up-regulating CCL22 expression via down-regulating miR-34a-5p. Yes The assays of cellular functions showed that circ_0039569 down-regulation suppressed the proliferation and metastasis of RCC cells. 31497210 hsa_circ_001287 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines regulation[miR-144-targeted CEP55] qRT-PCR//RIP//Western Blot circ_001287 and CEP55 were highly expressed while miR-144 was decreased in RCC tissues and cell lines. circ_001287 can up-regulate CEP55 by binding to miR-144, which resulted in increased proliferative, invasive and migratory capacities and tumor growth in vivo. In addition, down-regulation of miR-144 was also observed to promote these biological activities. Yes circ_001287 can up-regulate CEP55 by binding to miR-144, which resulted in increased proliferative, invasive and migratory capacities and tumor growth in vivo. 33256799 hsa_circ_400068 CircRNA Homo sapiens Carcinoma, Renal Cell RCC plasma exosomes, tissue samples and cells regulation[miR-210-5p/SOCS1 axis] Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Upregulation of circ_400068 was detected in RCC plasma exosomes, tissue samples and cells.Collectively, the present findings provided a novel insight into the crucial regulatory functions of circ_400068 in RCC, and the circ_400068/miR‑210‑5p/SOCS1 axis could be a candidate therapeutic target for the treatment of patients with RCC. Yes Additionally, treatment with exosomal circ_400068 promoted the proliferation and inhibited the apoptosis of healthy kidney cells, which were abrogated by short hairpin RNA?circ_400068. 33173957 hsa_circ_001504 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues regulation[circ_001504/miR-149/NUCB2 feedback loop] CCK8//qRT-PCR//Flow Cytometry RT-qPCR results showed that circ_001504 was highly expressed in RCC tissues, whereas miR-149 was poorly expressed.Collectively, reduced expression of circ_001504 lowered NUCB2 expression by sponging miR-149, thereby attenuating RCC progression, providing insight into circ_001504/miR-149/NUCB2 feedback loop into RCC treatment. Yes Interestingly, downregulation of circ_001504 suppressed malignant phenotypes in RCC cells, and upregulation of miR-149 exerted a similar effect. 33110207 circPTCH1 CircRNA Homo sapiens Carcinoma, Renal Cell RCC cell lines and tumor samples regulation[miR-485-5p/MMP14 axis] RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay We observed that circPTCH1 was up-regulated in RCC cell lines and tumor samples, circPTCH1 promotes RCC metastasis via the miR-485-5p/MMP14 axis and activation of the EMT process. We observed that circPTCH1 was up-regulated in RCC cell lines and tumor samples, and higher levels of circPTCH1 were significantly correlated with worse patient survival, advanced Fuhrman grade and greater risk of metastases. Yes Elevated circPTCH1 expression led to increased migration and invasion of RCC cells both in vitro and in vivo whereas silencing circPTCH1 decreased migration and invasion and impeded the epithelial-mesenchymal transition (EMT) of RCC cells. 32929380 circNUP98 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues regulation[miR-567/ PRDX3 axis] qRT-PCR//Western Blot CircNUP98 was up-regulated in both RCC tissues and cell lines, and high expression of circNUP98 was correlated with poor prognosis of RCC patients.CircNUP98 acts as an oncogene by a novel STAT3/circ NUP98/miR-567/PRDX3 axis, which may provide a potential biomarker and therapeutic target for the treatment of RCC. CircNUP98 was up-regulated in both RCC tissues and cell lines, and high expression of circNUP98 was correlated with poor prognosis of RCC patients. Yes Silencing of circSMC3 inhibited the proliferation and promoted the apoptosis in a caspase-dependent manner in RCC cells. 32729669 hsa_circ_001842 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines regulation[microRNA-502-5p,SLC39A14] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//ChIP Our initial in silico microarray-based analysis identified that circRNA circ_001842 was highly expressed in RCC. These observations imply the involvement of circ_001842 in RCC pathogenesis through a miR-502-5p-dependent SLC39A14 mechanism, suggesting circ_001842 is a potential target for RCC treatment. Yes circ_001842 was found to elevate SLC39A14 expression by binding to miR-502-5p, consequently resulting in augmented RCC cell proliferation, migration and invasion, as well as EMT in vitro and tumour growth in vivo. 32729666 hsa_circ_0001368 CircRNA Homo sapiens Carcinoma, Renal Cell carcinoma cells and tissues interaction[miR-492 and LATS2] qRT-PCR//Western Blot The qRT-PCR results indicate that the circ_0001368 expression level was downregulated in the carcinoma cells and tissues of the renal cell.Large tumor suppressor kinase 2 (LATS2) was confirmed by Targetscan as a target gene of miR-492. Yes The transwell and CCK8 assays showed that circ_0001368 suppressed cell proliferation and invasion in the ACHN and 786-O cells. 32428698 circMYLK CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues regulation[miR-513a-5p/VEGFC signalling ] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, we observed that circMYLK is notably up-regulated in RCC. In summary, our findings demonstrate that circMYLK has an oncogenic role in RCC growth and metastasis by modulating miR-513a-5p/VEGFC signalling. Increased circMYLK expression led to a larger tumour size, distant metastasis and poor prognosis of RCC patients. Yes Moreover, circMYLK silencing repressed RCC growth and metastasis in vitro and in vivo. 32342645 circMTO1 CircRNA Homo sapiens Carcinoma, Renal Cell cell lines regulation[miR9/LMX1A Axis] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay In the research, we selected a highly expressed novel circular RNAs named circMTO1 in renal cell carcinomas.In conclusion, circMTO1 suppresses renal cell carcinoma progression by circMTO1/miR9/ LMX1A, indicating that circMTO1 may be a potential target in renal cell carcinoma therapy. Yes We investigated the roles of circMTO1 and found that circMTO1 overexpression could suppress cell proliferation and metastases in both A497 and 786-O renal cancer cells, while silencing of circMTO1 could promote the progression in SN12C and OS-RC-2 renal cancer cells. 32207384 hsa_circ_0035483 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells Interaction( miR-31-5p-Mediated HMGA1 Upregulation) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Circ_0035483 expression was upregulated in RCC tissues and cells. MiR-31-5p was identified as a target of circ_0035483 and miR-31-5p upregulation was related to the function of circ_0035483 knockdown in RCC cells. Additionally, miR-31-5p targeted HMGA1 and inhibited the malignant behaviors of RCC cells by negatively regulating HMGA1. Yes The inhibitory effects on RCC cell proliferation, migration, invasion, EMT and glycolysis were induced after circ_0035483 was downregulated. Moreover, HMGA1 expression was regulated by circ_0035483 via targeting miR-31-5p. Circ_0035483 also affected tumor growth in vivo by relying on the miR-31-5p/HMGA1 axis. 33531839 circSDHC CircRNA Homo sapiens Carcinoma, Renal Cell patients with RCC Interaction(CDKN3/E2F1 axis) Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay Clinically, high circSDHC expression was correlated with advanced TNM stage and poor survival in patients with RCC. Analysis of the mechanism underlying the effects of circSDHC in RCC demonstrated that it binds competitively to miR-127-3p and prevents its suppression of a downstream gene, CDKN3, and the E2F1 pathway, thereby leading to RCC malignant progression. Furthermore, knockdown of circSDHC caused decreased CDKN3 expression and E2F1 pathway inhibition, which could be rescued by treatment with an miR-127-3p inhibitor. Clinically, high circSDHC expression was correlated with advanced TNM stage and poor survival in patients with RCC. Yes Further, circSDHC promoted tumor cell proliferation and invasion, both in vivo and in vitro. 33468140 circAMOTL1L CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines Interaction(miR-92a-2-5p/KLLN Pathway) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay qRT-PCR showed the downregulation of circAMOTL1L in RCC tissues and cell lines. Conclusively, our findings demonstrate that circAMOTL1L has an antioncogenic role in RCC growth by modulating the miR-92a-2-5p-KLLN pathway. The decrease in circAMOTL1L expression correlated with the tumor stage, metastasis, and poor prognosis in patients with RCC. Yes Functional experiments revealed that circAMOTL1L inhibited cell proliferation and increased apoptosis in RCC cells. Subcutaneous implantation with circAMOTL1L-overexpressing cells in nude mice decreased the growth ability of the xenograft tumors. 34646428 circCCDC66 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC specimens and cell lines Interaction(miR-129-5p/LARP1 ) Western Blot//CCK8//qRT-PCR//IHC//EdU Staining//Transwell Assay We observed that circ-CCDC66 expression was upregulated in PTC specimens and cell lines and was correlated with poor clinical characteristics of PTC patients. Mechanistically, miR-129-5p was a target gene of circ-CCDC66 and was downregulated in PTC tissues. LARP1, a downstream target of miR-129-5p, was upregulated in PTC tissues. We observed that circ-CCDC66 expression was upregulated in PTC specimens and cell lines and was correlated with poor clinical characteristics of PTC patients. Yes Moreover, in vitro experiments demonstrated that knockdown of circ-CCDC66 markedly suppressed the proliferative, migratory, and invasive capacities of PTC cells. In addition, we confirmed that inhibition of circ-CCDC66 could repress xenograft tumor growth. 35264065 hsa_circ_104565 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissue and cell Interaction(miR-134/ELF2 axis) CCK8//qRT-PCR//Luciferase Report Assay//Western Blot We found that circRNA_104565 was highly expressed in PTC tissue and cell and promoted cell proliferation in vitro and in vivo. In addition, circRNA_104565 promoted cell proliferation in PTC by regulating the miR-134/ELF2 axis. Yes We found that circRNA_104565 was highly expressed in PTC tissue and cell and promoted cell proliferation in vitro and in vivo. 33500653 hsa_circ_104718 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines(SMMC-7721, HepG2, MHCC-LM3, and SK-Hep1) Regulation[microRNA-218-5p/TXNDC5 signaling pathway] Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay The present study aims at investigating the role of circRNA-104718 in HCC progression, which has been observed to be significantly Expression[Expression[up-expression]-expression]-regulated in HCC tissues. We found that, higher expression of circRNA-104718 also leds to a poor prognosis in HCC patients.Using luciferase binding assays and RNA immunoprecipitation studies, we identified circRNA-104718 is physically associated and co-expressed with microRNA (miR)-218-5p in HCC.Mechanistically, we demonstrated that circRNA-104718 functions as a competing endogenous RNAs (ceRNAs) and competes with thioredoxin domain-containing protein 5 (TXNDC5) mRNA and directly binds to miR-218-5p. Yes In vivo studies on a nude mice model showed that circRNA-104718 overexpression could increase the tumor size and the rate of metastasis. Silencing of circRNA-104718 could decrease both the tumor size and metastasis significantly. 31278132 hsa_circ_0067934 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines Interaction(miR-1301-3p/HMGB1 axis) Tunel//Colony Formation Assay//qRT-PCR//Luciferase Report Assay//IHC We found that circ_0067934 was upregulated in PTC tissues and cell lines. Moreover, circ_0067934 acted as a molecular sponge for miR-1301-3p, and depletion of miR-1301-3p abrogated the effects of circ_0067934 knockdown in PTC cells. In addition, HMGB1 was a target of miR-1301-3p, and miR-1301-3p overexpression inhibited the malignant effects of PTC cells via suppressing HMGB1. Furthermore, knockdown of circ_0067934 suppressed HMGB1 expression, PI3K/Akt, and MAPK activation by sponging miR-1301-3p. Yes Knockdown of circ_0067934 inhibited growth, colony formation, migration, invasion, EMT, and tumor xenograft growth, and induced apoptosis of PTC cells. In nude mice, circ_0067934 depletion repressed tumor xenograft growth of PTC cells. 34704451 hsa_circ_0008274 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Regulation[AMPK/mTOR signaling pathway ] Western Blot//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay We found that has_circ_0008274 was significantly upregulated in PTC tissues, and the level of has_circ_0008274 was negatively associated with TNM stage and lymph node metastasis. Has_circ_0008274/ AMPK/mTOR axis may be a novel therapeutic candidate target in PTC treatment. We found that has_circ_0008274 was significantly upregulated in PTC tissues, and the level of has_circ_0008274 was negatively associated with TNM stage and lymph node metastasis. Yes Loss-of-function assay indicated that knockdown of has_circ_0008274 suppressed PTC cells proliferation and invasion in vitro. 30575918 hsa_circ_0004458 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Regulation[miR-885-5p,RAC1] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay Our results indicated that hsa_circ_0004458 was upregulated in PTC tissues and cells, while silencing of hsa_circ_0004458 suppressed PTC cell proliferation and promoted PTC cell cycle arrest and apoptosis in vitro. We found that hsa_circ_0004458 promoted the progression of PTC by inhibition of miR-885-5p and activation of RAC1, and hsa_circ_0004458 may serve as a potential therapeutic target and biomarker for PTC. Yes Our results indicated that hsa_circ_0004458 was upregulated in PTC tissues and cells, while silencing of hsa_circ_0004458 suppressed PTC cell proliferation and promoted PTC cell cycle arrest and apoptosis in vitro. Tumor formation assay in nude mice showed that knockdown of hsa_circ_0004458 by siRNAs inhibited the growth of PTC tumor in vivo. 30086127 circFOXM1 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues, cell lines Interaction[Sponging miR-1179] qRT-PCR//Luciferase Report Assay In this study, circFOXM1 was observed to be upregulated in PTC tissues and cell lines.Bioinformatics analysis predicted that there is a circFOXM1/miR-1179/high-mobility group box 1 (HMGB1) axis in PTC. A dual luciferase reporter system validated the direct interaction of circFOXM1, miR-1179, and HMGB1. A lower level of UPF1 was observed in glioma tissues in the more advanced stage with a larger tumor size. Yes circFOXM1 downregulation inhibited tumor growth of PTC in vitro and in vivo. 31951855 circBACH2 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues, cell lines Interaction[sponging miR-139-5p] qRT-PCR//Luciferase Report Assay//FISH We found that circBACH2 was highly expressed in PTC tissues and PTC cell lines.Mechanistically, we confirmed that circBACH2 could directly bind to miR-139-5p and relieve suppression of the target LMO4. Yes Functionally, we found that inhibiting circBACH2 expression decreased cell proliferation, migration, and invasion. Finally, down-regulating circBACH2 suppressed the growth of PTC xenografts in nude mice. 30796202 circPVT1 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction[sponging miR-126] qRT-PCR High expression of circPVT1 was shown in PTC tissues and cells and was associated with poor outcomes of patients.CircPVT1 knockdown inhibited PTC progression by sponging miR-126. This may indicate circPVT1 as a novel target for treatment of PTC. High expression of circPVT1 was shown in PTC tissues and cells and was associated with poor outcomes of patients. Yes Knockdown of circPVT1 suppressed viability, migration and invasion but induced apoptosis in PTC cells. 35520785 circPSD3 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tumor tissues regulation[miR-637/HEMGN axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_PSD3 was aberrantly up-regulated in PTC tumor tissues compared with adjacent normal tissues. Circ_PSD3/miR-637/HEMGN signaling axis might be a potential target for PTC therapy. Yes Circ_PSD3 and HEMGN promoted the cell cycle progression, proliferation and metastasis and impeded the apoptosis of PTC cells. 33203523 hsa_circ_0058124 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines regulation[miR-370-3p/LMO4 axis] qRT-PCR//Luciferase Report Assay The expression of circ_0058124 was enhanced in PTC tissues and cells. Circ_0058124 promoted the development of PTC by mediating the miR-370-3p/LMO4 axis, and circ_0058124, functioned as an oncogene in PTC, might be used as a promising biomarker for PTC diagnosis and treatment. Yes Circ_0058124 knockdown inhibited viability, colony formation, migration and invasion and promoted apoptosis of PTC cells. 33061633 circEIF3I CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues regulation[ circEIF3I/miR-149/KIF2A axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay We found that the expression of circEIF3I was significantly upregulated in PTC tissues compared to adjacent normal tissues.This study suggested circEIF3I/miR-149/KIF2A axis might be a potential therapeutic target. CircEIF3I expression was positively associated with tumor size, TNM stage and metastasis. Yes CircEIF3I knockdown remarkably suppressed the proliferation, migration and invasion of PTC cells. 32368390 hsa_circ_0007694 CircRNA Homo sapiens Thyroid Cancer, Papillary pericarcinomatous tissues Expression[lower expressed] qRT-PCR We identified a circRNA, hsa_circ_0007694 that was down-regulated in PTC tissues compared to pericarcinomatous tissues. Yes Over-expression of hsa_circ_0007694 promoted apoptosis and inhibited proliferation, migration, and invasion in PTC cells in vitro, and decreased tumor growth in vivo. 32355548 hsa_circ_0005273 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines regulation[circ_0005273/miR-1183/SOX2 axis] CCK8//qRT-PCR Gene Expression Omnibus datasets (GSE93522) and qRT-PCR (quantitative real-time PCR) analyses showed that circ_0005273 were upregulated in PTC tissues and cell lines.In conclusion, circ_0005273 functioned as a tumor promoter of PTC via circ_0005273/miR-1183/SOX2 axis, suggesting a novel biomarker and therapeutic target for PTC. Moreover, circ_0005273 was located in the cytoplasm of PTC cells and suggested poor prognosis in PTC patients. Yes In vivo and in vitro functional assays indicated that knockdown of circ_0005273 inhibited PTC tumor growth and progression, respectively. 31693489 circNRIP1 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(mir-195-5p ) qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Western Blot CircRNA NRIP1 was over-expressed in PTC tissues and cells and the high levels of CircRNA NRIP1 were correlated with advanced PTC stage. In conclusion, CircRNA NRIP1 promoted PTC progression by accelerating PTC cells proliferation, invasion and tumor growth, while impeding apoptosis by way of sponging miR-195-5p and regulating the P38 MAPK and JAK/STAT pathways. CircRNA NRIP1 was over-expressed in PTC tissues and cells and the high levels of CircRNA NRIP1 were correlated with advanced PTC stage. Yes Depletion of CircRNA NRIP1 inhibited PTC cell proliferation, invasion, while accelerated apoptosis. 34689819 hsa_circ_0008274 CircRNA Homo sapiens Thyroid Cancer, Papillary Tissue samples included 60 tumor tissues and 60 matched normal tissues Interaction(miR-154-3p) qRT-PCR//Luciferase Report Assay Our data showed that the high levels of circ_0008274 and SLC7A11 were associated with poor prognosis of PTC patients.Mechanistically, circ_0008274 modulated SLC7A11 expression by acting as a sponge of miR-154-3p. Our data showed that the high levels of circ_0008274 and SLC7A11 were associated with poor prognosis of PTC patients. Yes The knockdown of circ_0008274 or SLC7A11 enhanced PTC cell apoptosis and repressed cell migration and adhesion in vitro. Circ_0008274 knockdown suppressed tumor growth in vivo. 33473055 hsa_circ_0001666 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC clinical samples and cell lines Interaction(miR‑330‑5p/miR‑193a‑5p/miR‑326/ETV4 pathway) qRT-PCR//Western Blot//RIP//FISH The results demonstrated that hsa_circ_0001666 was upregulated in both PTC clinical samples and cell lines. Additionally, luciferase reporter assays showed that hsa_circ_0001666 and ETS variant transcription factor 4 (ETV4) shared common binding sites with three microRNAs [(miRNA/miR)‑330‑5p, miR‑193a‑5p and miR‑326]. Knockdown of these miRNAs separately reversed the inhibitory effect of hsa_circ_0001666 small interfering RNAs on PTC tumor aggressiveness, and ETV4 overexpression also induced a similar effect to that of miRNA inhibitors. Its expression was associated with lymph node metastasis of patients with PTC. Yes Knocking down hsa_circ_0001666 expression inhibited cell proliferation, as evidenced by decreased cell viability, arrest of cell cycle progression at the G1 phase and an increase in cell cycle‑associated proteins. Apoptosis rates and expression levels of pro‑apoptotic proteins were also increased by silencing hsa_circ_0001666. In xenograft experiments, the oncogenic effect of hsa_circ_0001666 on tumor growth was verified. 33760216 circLDLR CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines Interaction(miR-637/LMO4 Axis) Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay In this study, circLDLR was found to be markedly upregulated in PTC tissues and cell lines, and knockdown of circLDLR inhibited PTC cell proliferation, migration, and invasion but induced apoptosis in vitro. Moreover, circLDLR acted as a sponge for miR-637, and miR-637 interference reversed the anticancer effects of circLDLR knockdown on PTC cells. LMO4 was verified to be a target of miR-637; LMO4 upregulation abolished miR-637 mediated inhibition of cell growth and metastasis in PTC. Additionally, circLDLR could indirectly modulate LMO4 via acting as a sponge of miR-637 in PTC cells. Yes In this study, circLDLR was found to be markedly upregulated in PTC tissues and cell lines, and knockdown of circLDLR inhibited PTC cell proliferation, migration, and invasion but induced apoptosis in vitro. 34925640 hsa_circ_0062389 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines. Interaction(miR-1179/high mobility group box 1 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis Besides, miR-1179 was a downstream molecule of circ_0062389. Furthermore, miR-1179 inhibitors could partially reverse the above effect of knocking down circ_0062389 on PTC cells. It was also confirmed that HMGB1 was a direct target of miR-1179 and mediated the effects of circ_0062389 and miR-1179 in PTC. The high expression of circ_0062389 was related to large tumor size and positive lymphatic metastasis. Yes Knocking down circ_0062389 could inhibit the proliferation, migration and EMT process of PTC cells. 33926347 circPVT1 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines Interaction(miR-195/VEGFA/ Wnt/β-catenin signaling pathway) qRT-PCR//Western Blot The results of RT-PCR showed that the expression level of circPVT1 was significantly upregulated in PTC tissues and cell lines. Besides, miR-195 could both bind to PVT1 and VEGFA, while PVT1 could promote the expression of VEGFA by binding to miR-195. Downregulation of VEGFA expression in PTC cells revealed weakened cell proliferation, migration, and invasion capacities, and restrained Wnt/β-catenin signaling pathway. Yes After downregulating circPVT1 expression in PTC cells, the abilities of cell proliferation, migration, and invasion were obviously suppressed, and the Wnt/β-catenin signaling pathway was also repressed. 34927541 hsa_circ_007293 CircRNA Homo sapiens Thyroid Cancer, Papillary serum and cell culture media Interaction(microRNA-653-5p/paired box 6 axis) CCK8//qRT-PCR//Wound Healing Assay Results showed that circ007293 was enriched in exosomes derived from PTC patient serum and cell culture media. Additionally, circ007293 could competitively bind with miR-653-5p to regulate PAX6 expression. Notably, miR-653-5p overexpression or PAX6 inhibition suppressed the malignant effects of exosomal circ007293. Yes Moreover, circ007293 could enter PTC cells through exosomes, and exosomal circ007293 promoted PTC cell epithelial-mesenchymal transition, invasion, migration, and proliferation. circ007293 knockdown reversed the malignant phenotype of PTC cells in vitro. 34866540 hsa_circ_0039411 CircRNA Homo sapiens Thyroid Cancer, Papillary papillary thyroid carcinoma tissues and cell lines Interaction(miR-423-5p/SOX4 signaling) qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Western Blot Circ_0039411 was highly expressed in papillary thyroid carcinoma tissues and cell lines compared with adjacent normal tissues and NTHY-ORI3.1 cells. MiR-423-5p was a target of circ_0039411 in papillary thyroid carcinoma cells. Circ_0039411 knockdown-mediated effects in papillary thyroid carcinoma cells were largely overturned by the silence of miR-423-5p. MiR-423-5p bound to the 3' untranslated region (3'UTR) of SOX4. SOX4 overexpression largely reversed circ_0039411 silencing-mediated effects in papillary thyroid carcinoma cells. Circ_0039411 positively regulated SOX4 expression by sponging miR-423-5p in papillary thyroid carcinoma cells. Yes Circ_0039411 interference suppressed the colony formation ability, migration, invasion, and glycolysis but promoted the apoptosis of papillary thyroid carcinoma cells. Circ_0039411 silencing notably suppressed the growth of xenograft tumors in vivo. 34738852 hsa_circ_0054537 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells Interaction(circ_0054537/miR-640/NPTX2 ceRNA pathway) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//IHC//ChIP we found circ_0054537 was upregulated in RCC tissues and cells, and distributed throughout the cytoplasm. Yes functional effects of circ_0054537 in RCC were detected using cell counting kit-8, transwell, flow cytometry and glycolysis stress test and adenosine Triphosphate (ATP) assays. The results uncovered that circ_0054537 knockdown inhibited cell proliferation, migration, invasion, autophagy and glycolysis, but promoted apoptosis in RCC cells. Notably, circ_0054537 was identified as a ceRNA for microRNA (miR)-640, and miR-640 could target neuronal pentraxin-2 (NPTX2), as evidenced by dual-luciferase reporter assay and RNA immunoprecipitation assay.RCC cell growth in vivo was retarded by circ_0054537 silence. 34565284 circNTNG1 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells Interaction( circNTNG1/miR-19b-3p/HOXA5 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay In all three circRNA datasets, circNTNG1, which was frequently deleted in RCC, showed significantly low expression in the tumor group. Next, the sponge effect of circNTNG1 on miR-19b-3p and the inhibition of HOXA5 by miR-19b-3p were validated. GSEA analysis indicated that HOXA5 could inactivate the epithelial–mesenchymal transition (EMT) process, and this inactivation was mediated by HOXA5-induced SNAI2 (Slug) downregulation. Finally, it was confirmed that the Slug downregulation was caused by HOXA5, along with the DNA methyltransferase DNMT3A, binding to its promoter region and increasing the methylation level. Clinically, circNTNG1 expression was associated with RCC stage and Fuhrman grade, and it also served as an independent predictive factor for both OS and RFS of RCC patients. Yes The basic properties of circNTNG1 were characterized, and phenotype studies also demonstrated the inhibitory effect of circNTNG1 on RCC cell aggressiveness. 36536414 hsa_circ_0037866 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells Interaction( miR-384/CBX5) CCK8//qRT-PCR Circ_0037866 is a stable circRNA and was found to be increased in RCC tissues and cells.Mechanistically, circ_0037866 could function as a sponge for miR-384 to elevate the expression of its target CBX5. Furthermore, a series of rescue experiments showed that miR-384 inhibition reversed the anticancer effects of circ_0037866 knockdown on RCC cells; besides that, miR-384 restoration suppressed RCC cell growth and mobility, which were attenuated by CBX5 overexpression. Yes Functionally, circ_0037866 silencing suppressed RCC cell survival, invasion, and migration in vitro, and impeded RCC cell tumorigenesis in the subcutaneous xenograft model. 35249038 circSDHC CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines Interaction(miR-130a-3p/CEP55 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay We observed an observable elevation in circSDHC expression in RCC tissues and cell lines.Mechanically, circSDHC modulated centrosomal protein 55 (CEP55) expression by functioning as a miR-130a-3p sponge. Also, miR-130a-3p silencing offset circSDHC knockdown-mediated impacts on malignant phenotypes and angiogenesis of RCC cells. Furthermore, exogenetic expression of CEP55 counteracted miR-130a-3p overexpression-mediated effects on malignant phenotypes and angiogenesis of RCC cells. Yes Functionally, circSDHC silencing decreased xenograft tumor growth and induced RCC cell apoptosis, repressed RCC cell proliferation, angiogenesis, migration, and invasion in vitro. 35506422 hsa_circ_0083429 CircRNA Homo sapiens Osteoarthritis human chondrocytes Interaction(Mir-346/ SMAD3 Axis) qRT-PCR//Western Blot In our study, we found that Circ0083429 regulates the homeostasis of the extracellular matrix (ECM) in human chondrocytes. In conclusion, Circ0083429 regulates the ECM via the regulation of the downstream miRNA-346/SMAD3 in human chondrocytes, which provides a new therapeutic strategy for OA. Yes Mechanistically, Circ0083429 affects OA by regulating the mRNA level of SMAD3 through the sponging of microRNA (miRNA)-346. Injecting adeno-associated virus Circ0083429 into the intra-junction of the mouse knee alleviated OA. 33520980 hsa_circ_0128846 CircRNA Homo sapiens Osteoarthritis OA cartilage tissues Interaction(miR-127-5p/NAMPT axis) Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay Circ_0128846 and NAMPT were upregulated and miR-127-5p was downregulated in OA cartilage tissues. Moreover, circ_0128846 positively regulated NAMPT expression by sponging miR-127-5p. Furthermore, miR-127-5p promoted cell viability and suppressed apoptosis, inflammation, and ECM degradation in OA chondrocytes by directly targeting NAMPT. Yes Knockdown of circ_0128846 increased cell viability and inhibited apoptosis, inflammation and ECM degradation in OA chondrocytes, while these effects were reversed by downregulating miR-127-5p. 33975612 hsa_circ_0037658 CircRNA Homo sapiens Osteoarthritis CHON-001 cells Expression(highly expressed) CCK8//qRT-PCR//Cell Apoptosis Assay//Western Blot The results indicated that hsa_circ_0037658 was significantly upregulated in IL-1β-treated CHON-001 cells. Yes The silencing of hsa_circ_0037658 could protect CHON-001 cell injury against IL-1β. Moreover, hsa_circ_0037658 shRNA reversed IL-1β-induced cell growth inhibition via inducing cell autophagy. Furthermore, knockdown of hsa_circ_0037658 notably alleviated the symptom of OA in vivo. 32980988 circFAM160A2 CircRNA Homo sapiens Osteoarthritis OA tissue Interaction(miR-505-3p and SIRT3) Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis We found that miR-505-3p was upregulated and circFAM160A2 was downregulated in OA. While overexpression of circFAM160A2 decreased the production of extracellular matrix (ECM) degrading enzymes and ameliorated chondrocyte apoptosis and mitochondrial dysfunction, inhibition of miR-505-3p could reverse the protective effect of circFAM160A2 on the OA phenotype both in vitro and in vivo. Yes While overexpression of circFAM160A2 decreased the production of extracellular matrix (ECM) degrading enzymes and ameliorated chondrocyte apoptosis and mitochondrial dysfunction, inhibition of miR-505-3p could reverse the protective effect of circFAM160A2 on the OA phenotype both in vitro and in vivo. 34646424 circNFKB1 CircRNA Homo sapiens Osteoarthritis inflamed chondrocytes and osteoarthritic cartilage Interaction(NFKB1) qRT-PCR//IHC//RNA Pull-Down//IF We identified a highly upregulated circRNA, termed as circNFKB1 in inflamed chondrocytes and osteoarthritic cartilage. Mechanistically, circNFKB1 interacted with α-enolase (ENO1), regulated the expression of its parental gene NFKB1 and sustained the activation of NF-κB signaling pathway in chondrocytes. Yes Furthermore, knockdown of circNFKB1 inhibited extracellular matrix (ECM) catabolism and rescued IL-1β impaired ECM anabolism whereas ectopic expression of circNFKB1 significantly promoted chondrocytes degradation in vitro. Moreover, intraarticular injection of adenovirus-circNFKB1 in mouse joints triggered spontaneous cartilage loss and OA development. 35945200 hsa_circ_0114876 CircRNA Homo sapiens Osteoarthritis OA tissues, chondrocytes Interaction(miR-1227-3p/ADAM10 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//ELISA Circ_0114876 and ADAM10 were upregulated and miR-1227-3p was decreased in OA tissues and LPS-treated chondrocytes. Mechanistically, circ_0114876 functioned in human chondrocytes through targeting miR-1227-3p and ADAM10. Furthermore, miRNA-1227-3p inhibitor reversed the effect of circ_0114876 knockdown on the OA chondrocytes, and ADAM10 overexpression reversed the effect of miR-1227-3p mimic on the OA chondrocytes. Yes Low expression of circ_0114876 promoted proliferation and inhibited apoptosis, inflammation, and extracellular matrix of the LPS-treated chondrocytes. 36436795 circCDK14 CircRNA Homo sapiens Osteoarthritis chondrocytes, OA cartilage tissues Interaction(miR-1183/KLF5 ) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining CircCDK14 and KLF5 expression were significantly decreased, while miR-1183 was increased in OA cartilage tissues and IL-1β-treated chondrocytes in comparison with controls. Additionally, miR-1183 was targeted by circCDK14, and miR-1183 mimics reversed circCDK14-mediated actions in IL-1β-treated chondrocytes. The knockdown of KLF5, a target mRNA of miR-1183, also rescued the effects of miR-1183 inhibitors in IL-1β-induced chondrocytes. Moreover, circCDK14 could induce KLF5 expression by interacting with miR-1183. Yes CircCDK14 overexpression attenuated the inhibitory effect of IL-1β treatment on cell proliferation and the promoting effects on cell apoptosis and extracellular matrix degradation. 35723551 circNT5C2 CircRNA Homo sapiens Osteoarthritis OA tissues and in a cell model Interaction(miR-142-5p/NAMPT axis) Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//EdU Staining We reported that circ-NT5C2 and NAMPT were greatly upregulated, and miR-142-5p level was constrained in OA tissues and in a cell model. The targeting relationship of miR-142-5p with either circ-NT5C2 or NAMPT was confirmed. Knockdown of miR-142-5p reversed the suppressive effects of circ-NT5C2 silencing on the OA progression in vitro, and NAMPT overexpression also attenuated the effects of miR-142-5p upregulation in an OA cell model. Yes Circ-NT5C2 silencing alleviated IL-1β-induced inhibitory effects on chondrocyte proliferation and ECM generation, meanwhile the promotional role of IL-1β on chondrocyte apoptosis and inflammation was also weakened. 36540014 hsa_circ_0022383 CircRNA Homo sapiens Osteoarthritis OA patients and chondrocytes Interaction(miR-3619-5p/SIRT1 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA//EdU Staining Circ_0022383 expression was lower in the cartilages of OA patients and IL-1β-induced primary chondrocytes. Mechanistically, circ_0022383 acted as a sponge for miR-3619-5p, which was verified to target SIRT1. Rescue experiments showed that miR-3619-5p up-regulation reversed the protective effects of circ_0022383 on IL-1β-stimulated chondrocytes. Additionally, miR-3619-5p inhibition abolished IL-1β-induced apoptosis, inflammation and ECM degeneration in chondrocytes, which were counteracted by SIRT1 silencing. Yes Functionally, ectopic overexpression of circ_0022383 alleviated IL-1β-induced proliferation arrest, apoptosis, the release of IL-6 and TNF-α, as well as the decrease of ACAN and COL2A1 and the increase of ADAMTS5 level in chondrocytes. 36194985 hsa_circ_0043947 CircRNA Homo sapiens Osteoarthritis chondrocytes Interaction(miR-671-5p/RTN3 ) Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay Interleukin 1β (IL-1β) stimulation up-regulated the expression of circ_0043947 in chondrocytes. Circ_0043947 interacted with miR-671-5p, and miR-671-5p silencing largely reversed circ_0043947 knockdown-mediated protective effects in IL-1β-induced chondrocytes. miR-671-5p interacted with the 3' untranslated region (3'UTR) of RTN3. miR-671-5p overexpression attenuated IL-1β-induced injury in chondrocytes, and these protective effects were largely overturned by the overexpression of RTN3. Circ_0043947 acted as a molecular sponge for miR-671-5p to up-regulate RTN3 level in chondrocytes. Yes IL-1β treatment restrained the viability and proliferation and induced the apoptosis, extracellular matrix degradation and inflammatory response of chondrocytes partly by up-regulating circ_0043947. 35331286 circSCAPER CircRNA Homo sapiens Osteoarthritis chondrocytes Interaction(miR-127-5p/TLR4 axis ) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//ELISA CircSCAPER was increased in OA cartilages and IL-1β-induced chondrocytes. Mechanistically, circSCAPER acted as a sponge for miR-127-5p to positively regulate TLR4 expression in chondrocytes. IL-1β treatment reduced miR-127-5p expression but up-regulated TLR4 expression, re-expression of miR-127-5p suppressed IL-1β-caused chondrocyte injury, which was abolished by TLR4 overexpression. Moreover, miR-127-5p inhibition reversed the protective action of circSCAPER knockdown on chondrocytes under IL-1β treatment. Yes Functionally, knockdown of circSCAPER attenuated IL-1β-evoked apoptosis, ECM degradation, inflammation and oxidative stress in vitro. CircSCAPER up-regulation in OA cartilages was discovered to be accompanied by decreased miR-127-5p and increased TLR4. 35993243 hsa_circ_001569 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue specimens and cells interaction[miR-411-5p and miR-432-5p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results indicated that circ_001569 was overexpressed in HCC tissue samples and cells. More importantly, circ_001569 could directly sponge miR-411-5p and miR-432-5p. This overexpression is correlated with larger tumor size, advanced TNM stages and unfavorable prognosis in the patients with HCC. Yes Additionally, circ_001569 significantly facilitated HCC cell growth, migration and invasion. The animal studies further confirmed thein vitroresults. 30086881 circRHOT1 CircRNA Homo sapiens Carcinoma, Hepatocellular  HCC tissues and adjacent normal tissues Interaction[ initiation of NR2F6] Northern Blot//ISH//qRT-PCR//RIP//FISH We identified circRHOT1 (hsa_circRNA_102034) as a conserved and dramatically upregulated circRNA in HCC tissues.Taken together, circRHOT1 inhibits HCC development and progression via recruiting TIP60 to initiate NR2F6 expression, indicating that circRHOT1 and NR2F6 may be potential biomarkers for HCC prognosis. HCC patients displaying high circRHOT level possessed poor prognosis. Yes Through in vitro and in vivo experiments, we demonstrated circRHOT1 significantly promoted HCC growth and metastasis. 31324186 hsa_circ_5692 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC and adjacent non-tumor tissues,cell lines(Huh-7、SMMC-7721、HCCLM3、MHCC997H , HepG2) Interaction[ circRNA-5692-miR-328-5p-DAB2IP regulatory pathway ] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay It was notable that the circRNA-5692 was encoded by the GLIS2 gene and most significantly downregulated in five HCC tissues and HCC cells. In conclusion, the circRNA-5692-miR-328-5p-DAB2IP regulatory pathway inhibits the progression of HCC. Our findings may provide potential new targets for the diagnosis and therapy of HCC. Yes Moreover, circRNA-5692 overexpression inhibited the growth of xenograft HCC tumors in vivo by decreasing miR-328-5p expression to enhance DAB2IP expression. 31776329 circPTPRM CircRNA Homo sapiens Carcinoma, Hepatocellular HCC samples and their corresponding adjacent non-tumorous liver (ANL) tissue Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//MTT//RNA-seq The Expression[Expression[up-expression]-expression]regulation of circPTPRM was observed in 73.3% (22/30) of HCC tissues, which was significantly higher than paired ANL tissues (p = 0.023, Fig. 2a, b). circSMAD2 expression in HCC tissues was significantly higher than paired samples (p = 0.0026, Fig. 2a, b). No statistically significant differences in circPTBP3 expression in HCC and ANL tissues were observed (p = 0.107, Fig. 2a, b). Yes In over-confluent cells, circPTPRM expression was significantly reduced (p < 0.01, Fig. 3a). To examine the functional roles of circPTPRM in HCC, we silenced its expression in Huh7 and SMMC-7721 cells using circPTPRM-siRNA-1 and circPTPRM-siRNA-2. circPTPRM silencing was confirmed by qRT-PCR 48 h post-transfection (Fig. 3b). MTT and colony-formation assays were performed to detected proliferation. Compared to control groExpression[Expression[up-expression]-expression]s, cancer cell proliferation was sExpression[Expression[up-expression]-expression]pressed in circPTPRM low-expression groExpression[Expression[up-expression]-expression]s by MTT analysis 72 h and 120 h post-transfection (p < 0.01, Fig. 3c). Consistent with the MTT data, colony-formation assay showed that low-circPTPRM expression led to a significant reduction of colony numbers in HCC cells (p < 0.01, Fig. 3d). These results confirmed that circPTPRM accelerates proliferation in HCC. 31494761 circSMAD2 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC samples and their corresponding adjacent non-tumorous liver (ANL) tissue Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//MTT//RNA-seq The Expression[Expression[up-expression]-expression]regulation of circPTPRM was observed in 73.3% (22/30) of HCC tissues, which was significantly higher than paired ANL tissues (p = 0.023, Fig. 2a, b). circSMAD2 expression in HCC tissues was significantly higher than paired samples (p = 0.0026, Fig. 2a, b). No statistically significant differences in circPTBP3 expression in HCC and ANL tissues were observed (p = 0.107, Fig. 3a, b). Yes In over-confluent cells, circPTPRM expression was significantly reduced (p < 0.01, Fig. 3a). To examine the functional roles of circPTPRM in HCC, we silenced its expression in Huh7 and SMMC-7721 cells using circPTPRM-siRNA-1 and circPTPRM-siRNA-2. circPTPRM silencing was confirmed by qRT-PCR 48 h post-transfection (Fig. 3b). MTT and colony-formation assays were performed to detected proliferation. Compared to control groExpression[Expression[up-expression]-expression]s, cancer cell proliferation was sExpression[Expression[up-expression]-expression]pressed in circPTPRM low-expression groExpression[Expression[up-expression]-expression]s by MTT analysis 72 h and 120 h post-transfection (p < 0.01, Fig. 3c). Consistent with the MTT data, colony-formation assay showed that low-circPTPRM expression led to a significant reduction of colony numbers in HCC cells (p < 0.01, Fig. 4d). These results confirmed that circPTPRM accelerates proliferation in HCC. 31494761 circPTBP3 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC samples and their corresponding adjacent non-tumorous liver (ANL) tissue Expression[No differently] qRT-PCR//MTT//RNA-seq The Expression[Expression[up-expression]-expression]regulation of circPTPRM was observed in 73.3% (22/30) of HCC tissues, which was significantly higher than paired ANL tissues (p = 0.023, Fig. 2a, b). circSMAD2 expression in HCC tissues was significantly higher than paired samples (p = 0.0026, Fig. 2a, b). No statistically significant differences in circPTBP3 expression in HCC and ANL tissues were observed (p = 0.107, Fig. 4a, b). Yes In over-confluent cells, circPTPRM expression was significantly reduced (p < 0.01, Fig. 3a). To examine the functional roles of circPTPRM in HCC, we silenced its expression in Huh7 and SMMC-7721 cells using circPTPRM-siRNA-1 and circPTPRM-siRNA-2. circPTPRM silencing was confirmed by qRT-PCR 48 h post-transfection (Fig. 3b). MTT and colony-formation assays were performed to detected proliferation. Compared to control groExpression[Expression[up-expression]-expression]s, cancer cell proliferation was sExpression[Expression[up-expression]-expression]pressed in circPTPRM low-expression groExpression[Expression[up-expression]-expression]s by MTT analysis 72 h and 120 h post-transfection (p < 0.01, Fig. 3c). Consistent with the MTT data, colony-formation assay showed that low-circPTPRM expression led to a significant reduction of colony numbers in HCC cells (p < 0.01, Fig. 5d). These results confirmed that circPTPRM accelerates proliferation in HCC. 31494761 hsa_circ_0079929 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines(SK-Hep-1，SMMC-7721，7702，LM-3,PRL-RF5) Regulation[PI3K/AKT/mTOR signaling pathway] Wound Healing Assay//CCK8//qRT-PCR//EdU Staining//Transwell Assay The expression of hsa_circ_0079299 was lower in HCC tissues. The inhibitory effect of hsa_circ_0079299 was partly mediated by PI3K/AKT/mTOR signaling pathway. Yes Overexpression of hsa_circ_0079299 sExpression[Expression[up-expression]-expression]pressed tumor growth in vitro and in vivo, retarded cell cycle progression while had no effect on cell migration and apoptosis. 30655696 circFOXP9 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues, serum and cell lines Interaction[miR-875-3p and miR-421] Other We found that circ-FOXP1 was significantly Expression[Expression[up-expression]-expression]regulated in HCC tissues, serum and cell lines., which was attributed to the Expression[Expression[up-expression]-expression]regulation of oncogenic transcription factor SOX9. Further mechanismic study revealed that circ-FOXP1 was preferentially located in the cytoplasm and could concurrently sponge miR-875-3p and miR-421, resulting in increasing levels of a cohort of their target oncogenes, including SOX9. Clinically, high circ-FOXP1 was closely correlated with larger tumor size, microvascular invasion, advanced TNM stage, and predicted poor prognosis. Yes Moreover, knockExpression[down-expression] of circ-FOXP1 evidently retarded tumor growth in vivo, but this effect was significantly abolished after silencing of miR-875-3p or miR-421. 31698267 circPDE4D CircRNA Homo sapiens Osteoarthritis OA cartilage tissues Interaction(miR-103a-3p-FGF18) FISH//Northern Blot//Luciferase Report Assay//Western Blot circPDE4D was significantly downregulated in OA cartilage tissues and during stimulation with inflammatory cytokines. echanistically, we found that circPDE4D exerted its effect by acting as a sponge for miR-103a-3p and thereby regulated FGF18 expression, which is a direct target of miR-103a-3p. Yes The knockdown of circPDE4D predominantly contributed to Aggrecan loss and the upregulation of matrix catabolic enzymes, including MMP3, MMP13, ADAMTS4, and ADAMTS5, but not proliferation or apoptosis. In a murine model of destabilization of the medial meniscus (DMM), the intraarticular injection of circPDE4D alleviated DMM-induced cartilage impairments. 33125858 hsa_circ_0001598 CircRNA Homo sapiens Osteoarthritis OA models Interaction(miR-127-3p) CCK8//qRT-PCR//Tunel//Western Blot In this study, we found that circ_0001598 was significantly upregulated in chondrocytes treated with IL-1β and in cartilage tissue from mice with severed anterior cruciate ligament surgery (ACLT) induced OA models.Mechanistically, knockdown of circ_0001598 affected chondrocyte proliferation, apoptosis, and matrix degradation by regulating miR-127-3p. Yes Interference with circ_0001598 in vitro restored IL-1β-induced chondrocyte proliferation and apoptosis. Silencing circ_0001598 significantly alleviated ACLT-induced OA in mice. 34917303 circSLC7A2 CircRNA Homo sapiens Osteoarthritis OA model and OA tissues Interaction(miR-4498/TIMP3 axis) Other circSLC7A2 was decreased in OA model and the circularization of circSLC7A2 was regulated by FUS. We further determined that miR-4498 inhibitor reversed circSLC7A2-knockdown-induced OA phenotypes. Intra-articular injection of circSLC7A2 alleviated in vivo OA progression in a mouse model of anterior cruciate ligament transection (ACLT). Yes Loss of circSLC7A2 reduced the sponge of miR-4498 and further inhibited the expression of TIMP3, subsequently leading to an inflammatory response. We further determined that miR-4498 inhibitor reversed circSLC7A2-knockdown-induced OA phenotypes. Intra-articular injection of circSLC7A2 alleviated in vivo OA progression in a mouse model of anterior cruciate ligament transection (ACLT). 33960555 hsa_circ_0136474 CircRNA Homo sapiens Osteoarthritis OA cartilage tissue Interaction[binding to miR-127-5p] qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Western Blot Our findings revealed that the expression levels of both Circ_0136474 and MMP-13 in OA cartilage tissue were significantly higher than that in normal cartilage tissue. Our study demonstrated that Circ_0136474 and MMP-13 suppressed cell proliferation, while enhanced cell apoptosis by competitive binding to miR-127-5p in OA, which may well provide us with a new therapeutic strategy for osteoarthritis. Yes Overexpression of miR-127-5p negatively regulated MMP-13 expression to enhance cell proliferation. Our study demonstrated that Circ_0136474 and MMP-13 suppressed cell proliferation, while enhanced cell apoptosis by competitive binding to miR-127-5p in OA, which may well provide us with a new therapeutic strategy for osteoarthritis. 31402547 circVAMP3 CircRNA Homo sapiens Carcinoma, Renal Cell RCC patients and cells Interaction( circVAMP3-LDHA/FGFR1) In Vivo Experiment//Invasion Assay//Migration Assay//CCK8//qRT-PCR//Bioinformatics Analysis Furthermore, circVAMP3 expression was elevated in RCC patients in correspondence with TNM stage.Mechanistically, circVAMP3 was observed to interact directly with lactate dehydrogenase A (LDHA) and modulate its activity. The circVAMP3-LDHA interaction facilitated LDHA phosphorylation at tyrosine 10 (Y10) catalyzed by the upstream kinase fibroblast growth factor receptor type 1 (FGFR1). Furthermore, circVAMP3 expression was elevated in RCC patients in correspondence with TNM stage. Yes Therefore, this study reveals a novel molecular mechanism by which circVAMP3 promotes glycolysis and proliferation through regulating the enzymatic activity of glycolytic enzyme, suggesting that circVAMP3 may represent an RCC biomarker and treatment target. 35525866 circSCNN1A CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells Interaction(miR-421/MPP7 axis ) Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The level of circSCNN1A was significantly downregulated in RCC tissues and cells.Interestingly, circSCNN1A could interact with miR-421. Overexpression of miR-421 has reversed the anti-tumor function of circSCNN1A in RCC cells. MPP7 served as a target of miR-421, and MPP7 inhibited the malignant phenotypes of RCC cells. In addition, miR-421 downregulation induced the inhibitory effect on the RCC development via elevating the MPP7 level. Yes RCC cell proliferation, invasion and angiogenesis were reduced but apoptosis was promoted by circSCNN1A overexpression. Moreover, RCC tumorigenesis was suppressed by circSCNN1A through the miR-421/MPP7 axis in vivo. 36343886 hsa_circ_0000798 CircRNA Homo sapiens Carcinoma, Renal Cell RCC patients' tumors and cells Interaction(miR-589-5p/G3BP1) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Circ_0000798 is upregulated in RCC patients' tumors and cells, and high circ_0000798 is associated with shorter overall survival. Proliferation markers Ki67 and Bcl-2 were depressed by inhibiting circ_0000798, accompanied with promoted levels of apoptosis proteins Bax and cleaved caspase-3. Of note, circ_0000798 functions as microRNA (miR) sponge for miR-589-5p and thus controls the expression of miR-589-5p-targeting Ras-GTPase-activating protein-binding protein 1 (G3BP1), a newly identified tumor-promoting gene in RCC. Circ_0000798 is upregulated in RCC patients' tumors and cells, and high circ_0000798 is associated with shorter overall survival. Yes RNA interference of circ_0000798 impedes cell metabolic viability and abilities of DNA synthesis, colony formation, wound healing, migration, and invasion in RCC cells but also induces cell cycle arrest and apoptosis. Moreover, circ_0000798 interference could delay tumor growth in vivo. 35857217 hsa_circ_0008717 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells Interaction(miR-217/FBXO17 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay Circ_0008717 was upregulated in RCC tissues and cells. MiR-217 was a target of circ_0008717 and bound to the FBXO17 3' untranslated region. The expression of FBXO17 was positively regulated by circ_0008717 but impaired by miR-217 reintroduction. The inhibitory effects of circ_0008717 knockdown on RCC cell malignant behaviors were reversed by miR-217 inhibition or FBXO17 overexpression. Circ_0008717 knockdown inhibited tumor growth in vivo by regulating miR-217 and FBXO17. Yes Silencing circ_0008717 suppressed RCC cell proliferation, migration, invasion and glycolysis but promoted cell apoptosis. 35357059 hsa_circ_0005875 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells Interaction(miR-502-5p/ETS1 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Circ_0005875 and ETS1 were upregulated and miR-502-5p was downregulated in RCC tissues and cells. MiR-502-5p was a target of circ_0005875, and miR-502-5p inhibition reversed the inhibitory effects of circ_0005875 knockdown on the malignant behaviors of RCC cells. ETS1 was a direct target of miR-502-5p, and miR-502-5p exerted its anti-tumor role in RCC cells by targeting ETS1. Moreover, circ_0005875 knockdown decreased ETS1 expression by sponging miR-502-5p. Circ_0005875 knockdown suppressed RCC progression by regulating miR-502-5p/ETS1 axis, which might provide a promising therapeutic target for RCC. Yes Knockdown of circ_0005875 suppressed RCC cell proliferation, migration and invasion, and induced apoptosis and cell cycle arrest. Additionally, circ_0005875 depletion suppressed tumor growth in vivo. 34407050 hsa_circ_000829 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells Interaction(SRSF1/SLC39A14) Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Invasion Assay Circ_000829 was poorly expressed in RCC tissues and cells, while SRSF1 was highly expressed. Mechanistically, circ_000829 directly bound to SRSF1, and SRSF1 enhanced the expression of SLC39A14B by mediating the alternative splicing of SLC39A14. SLC39A14B upregulation negated the effect of SLC39A14 knockdown on RCC cell proliferation. Yes Restoration of circ_000829 reduced the levels of SRSF1 and SLC39A14B, thereby repressing the RCC cell proliferation in vitro and tumor growth in vivo. Meanwhile, overexpression of SRSF1 and SLC39A14B promoted the proliferation and cell cycle entry of RCC cells. 36062189 hsa_circ_0000274 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells Interaction(miR-338-3p/NUCB2/JAK1/STAT3 pathway) Western Blot//Flow Cytometry//qRT-PCR//RIP//CCK8//ChIP Compared to normal tissues and cells, circ_0000274 RNA level was elevated in RCC tissues and cells. Circ_0000274 RNA sponged miR-338-3p RNA to positively regulate NUCB2 protein in RCC cells. Inhibition of miR-338-3p reversed the impacts of circ_0000274 knockdown on RCC cell malignant behaviors. MiR-338-3p RNA overexpression repressed the malignant phenotypes of RCC cells, while NUCB2 protein elevation could abrogate the effect. Moreover, circ_0000274 RNA knockdown blocked tumorigenesis in vivo. Besides, circ_0000274 RNA knockdown inactivated the JAK1/STAT3 protein signaling pathway. Yes Knockdown of circ_0000274 RNA suppressed cell viability, colony formation, metastasis and tube formation and promoted apoptosis in RCC cells in vitro. 35569717 circsafb2 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and RCC-derived exosomes Interaction(miR-620/JAK1/STAT3 axis) In Vivo Experiment//IHC//Western Blot//Tube Formation Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our data first demonstrated that circSAFB2 leads to immune escape from RCC by mediating M2 macrophage polarization via the miR-620/JAK1/STAT3 axis. These findings indicate a novel molecular mechanism of exosomal circSAFB2 in the progression of RCC and implicate circSAFB2 as a target for exosome-mediated tumor immune evasion. Yes Furthermore, we demonstrated that exosomal circSAFB2 mediates the polarization of M2 macrophages through the miR-620/JAK1/STAT3 axis to promote RCC metastasis. 35646637 circSEC24A CircRNA Homo sapiens Osteoarthritis osteoarthritic cartilage tissues Interaction(miR-26b-5p/DNMT3A) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//ELISA//IF Circ_SEC24A was upregulated in osteoarthritic cartilage tissues and IL-1β-induced chondrocytes, accompanying with miR-26b-5p downregulation and DNMT3A upregulation.Inhibiting miR-26b-5p counteracted but upregulating miR-26a-5p mimicked the functions of circ_SEC24A silencing. Reinforcing DNMT3A reversed miR-26b-5p overexpression's role in IL-1β-induced chondrocytes. Mechanically, circ_SEC24A and DNMT3A were competitive endogenous RNAs (ceRNAs) for miR-26b-5p. Yes Interfering circ_SEC24A abolished IL-1β-induced effects on proliferation inhibition, apoptosis, and ECM degradation in chondrocytes, but overexpressing circ_SEC24A had the opposite effects. 34325283 circHIPK3 CircRNA Homo sapiens Osteoarthritis OA tissues and OA chondrocytes regulation[as a sponge of miR-124 to regulate SOX8] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Western Blot High expressed CircHIPK3 and low expressed miR-124 were found in OA tissues and OA chondrocytes.Low expression of CircHIPK3 promoted the apoptosis of OA chondrocytes by promoting miR-124 to suppress SOX8 expression. Yes To our surprise, knocking down CircHIPK3 and transfected miR-124 mimics both inhibited the apoptosis of OA chondrocytes. 32767319 circPSM3 CircRNA Homo sapiens Osteoarthritis OA cartilage tissue and cells interaction[ targeting miRNA-296-5p] qRT-PCR//Luciferase Report Assay//RIP//Western Blot CircPSM3 expression was upregulated in OA cartilage tissue and cells. CircPSM3 participated in the proliferation and differentiation of OA chondrocytes through targeted binding to miRNA-296-5p. Yes Low expression of CircPSM3 promoted the proliferation and cell differentiation of OA chondrocytes. 32329819 circANKRD36 CircRNA Homo sapiens Osteoarthritis human chondrocytes Interaction(miR-599) qRT-PCR We performed circRNA sequencing in normal and OA tissues and found the expression of circANKRD36 is decreased in OA tissues. We then found miR-599 to be the target of circANKRD36 and correlate well with circANKRD36 both in vitro and in vivo. Yes knockdown of circANKRD36 promotes the apoptosis and inflammation of chondrocytes in IL-1β stress. 33205602 hsa_circ_0134111 CircRNA Homo sapiens Osteoarthritis cell lines Interaction(miR-224-5p/CCL1 axis) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//FISH//CCK8//Luciferase Report Assay//ELISA In this study, the effects of hsa_circ_0134111 knockdown were evaluated in primary human chondrocytes treated with IL-1β to simulate OA, as well as in a rat model of OA. These results suggest that hsa_circ_0134111 contributes to OA development by binding to miR-224-5p, thereby releasing the inhibition that miR-224-5p exerts over CCL1. Yes CCK-8 and flow cytometry assays showed that hsa_circ_0134111 knockdown reversed IL-1β-induced cell decline by inhibiting apoptosis.  34413269 hsa_circ_0116061 CircRNA Homo sapiens Osteoarthritis OA cartilage tissues Interaction(miR-200b-3p/SMURF2 axis) Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Cell Viability Assay//ELISA//IHC Circ_0116061 and SMURF2 were highly expressed, and miR-200b-3p was lowly expressed in OA cartilage tissues. MiR-200b-3p could be sponged by circ_0116061, and its inhibitor could reverse the regulation of circ_0116061 silencing on the biological functions of OA chondrocytes. SMURF2 was a target of miR-200b-3p, and its expression was positively regulated by circ_0116061. Yes Knockdown of circ_0116061 could promote the proliferation and inhibit the apoptosis and inflammation of OA chondrocytes. 33849596 hsa_circ_0005567 CircRNA Homo sapiens Osteoarthritis synovial tissues of osteoarthritis patients Interaction(miR-492/SOCS2 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay The results showed that the hsa_circ_0005567 expression level was downregulated in the synovial tissues of osteoarthritis patients. Hsa_circ_0005567 was proved to be a molecular sponge for miR-492, and SOCS2 was verified as the target of miR-492. Yes Overexpression of hsa_circ_0005567 inhibited M1 macrophage polarization, and promoted M2 macrophage polarization. 34652255 hsa_circ_0032131 CircRNA Homo sapiens Osteoarthritis CHON-001 cells and an OA rat model. Interaction(miR-502-5p/PRDX3 axis) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Viability Assay We investigated the functions of hsa_circ_0032131, a circRNA upregulated in OA, using CHON-001 cells and an in vivo OA rat model. Yes IL-1β-induced inhibition of CHON-001 growth was reversed by silencing hsa_circ_0032131. In addition, hsa_circ_0032131 knockdown reversed IL-1β-induced activation of Trx1, Cyclin D and PRDX3, whereas overexpression of PRDX3, a direct target of miR-502-5p, reversed this effect. 34032607 circCTNNA1 CircRNA Homo sapiens Osteoarthritis OA tissues Interaction(miR-29a ) CCK8//qRT-PCR//IF//Western Blot CircCTNNA1 was downregulated in OA, while miR-29a was overexpressed in OA. RNA pull-down assay illustrated the direct interaction between circCTNNA1 and miR-29a. Yes CircCTNNA1 overexpression suppressed the enhancing effects of miR-29a overexpression on cell apoptosis induced by LPS. 34751080 hsa_circ_0003141 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-1827/UBAP2 axis] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay Using bioinformatics analysis, we have found that the expression of circRNA hsa_circ_0003141 is significantly increased in HCC tissues. Together, our results indicate that hsa_circ_0003141 functions as an oncogene in HCC cells, and suggest that the hsa_circ_0003141/miR-1827/UBAP2 axis might represent a novel therapeutic option for the treatment of HCC. Ubiquitin-associated protein 2 (UBAP2) is the parent gene for hsa_circ_0003141, and its high expression correlates with poor overall survival rates in HCC patients. Yes Downregulation of hsa_circ_0003141 suppresses UBAP2 expression, induces apoptosis, and inhibits proliferation and invasion by HCC Huh-7 cells. 32464601 circZNF609 CircRNA Homo sapiens Carcinoma, Hepatocellular regulation[miR-15a-5p/15b-5p and GLI2 expressions] RNA Pull-Down//Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Briefly, circZNF609 enhances HCC cell proliferation, metastasis, and stemness by activating the Hedgehog pathway through the regulation of miR-15a-5p/15b-5p and GLI2 expressions. Yes Functional tests revealed that decreased expression of circZNF609 suppressed cell proliferation, metastasis and stemness, whereas induced cell apoptosis in HCC. 32398664 circMAST1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues interaction[miR-1299,CTNND1] Western Blot//Flow Cytometry//qRT-PCR//Colony Formation Assay//Transwell Assay CircMAST1 was upregulated in HCC tissues and cell lines; silencing via small interfering RNA inhibited migration, invasion, and proliferation of HCC cell lines in vitro as well as tumor growth in vivo.Moreover, circMAST1 elicits HCC progression by sponging miRNA-1299 and stabilizing CTNND1. Yes CircMAST1 was upregulated in HCC tissues and cell lines; silencing via small interfering RNA inhibited migration, invasion, and proliferation of HCC cell lines in vitro as well as tumor growth in vivo. 32393764 hsa_circ_002136 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-19a-3p/RAB1A pathway) qRT-PCR Circ_002136 was shown for the first time to be differentially upregulated in HCC tissues and cells and transferred by HCC cell-derived exosomes. Furthermore, a well-established circ_002136 ceRNA regulatory network was constructed, namely circ_002136 blocked miR-19a-3p expression, elevated RAB1A expression activity and stimulated HCC development. Finally, high levels of circ_002136 or RAB1A, as well as low levels of miR-19a-3p, negatively affected HCC patient survival. Yes More importantly, selective silencing of circ_002136 depleted the malignant biological behaviors of HCC exosome-activated Huh7 and HA22T cells. Depletion of circ_002136 in vivo effectively retarded the growth of HCC xenograft tumors. 36476239 circSNX27 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-637/FGFR1 axis) qRT-PCR The circ_SNX27 and FGFR1 levels were up-regulated, but miR-637 content was reduced in HCC. Circ_SNX27 served as a sponge of miR-637 to promote FGFR1 expression. MiR-637 reduction abolished the restrained effect of circ_SNX27 absence on HCC cell development. Moreover, miR-637 curbed HCC cell malignant phenotype by regulating FGFR1. Yes Circ_SNX27 down-regulation inhibited HCC cell proliferation, motility, and invasion and promoted apoptosis in vitro, as well as weakened tumor growth in vivo. 36029209 circWDR25 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miRNA-4474-3P-ALOX-15 and EMT axes) RNA Pull-Down//Luciferase Report Assay//FISH We found that overexpressed peritumoral circWDR25 was associated with survival and recurrence in patients with HCC and promoted the progression of HCC cells both in vitro and in vivo. Mechanistically, both exogenous and HSC exosomal-derived circWDR25 regulated the expression of ALOX15 by sponging miR-4474-3p and ultimately inducing an epithelial-to-mesenchymal transition (EMT) in HCC cells. Moreover, exogenous and HSC exosomal-derived circWDR25 promoted the expression of CTLA-4 in HSCs and PD-L1 in HCC cells. We found that overexpressed peritumoral circWDR25 was associated with survival and recurrence in patients with HCC and promoted the progression of HCC cells both in vitro and in vivo. Yes We found that overexpressed peritumoral circWDR25 was associated with survival and recurrence in patients with HCC and promoted the progression of HCC cells both in vitro and in vivo. 35934785 circRanGAP1 CircRNA Homo sapiens Carcinoma, Hepatocellular cells and clinical tissues Interaction(miR-27b-3p/NRAS Axis ) qRT-PCR Here, we found elevated circRanGAP1 in the cells and clinical tissues of patients with HCC. Moreover, circRanGAP1 is mainly located inside the cytoplasm. Mechanistically, circRanGAP1 as an oncogene promotes HCC progression by miR-27b-3p/NRAS/ERK axis, furthermore, affects the infiltration level of tumor-associated macrophages probably by sponging miR-27b-3p. Increased circRanGAP1 levels are associated with enlarged tumors and the advanced stage of TNM. Yes CircRanGAP1 promotes the growth, migration, and HCC cell invasion, concurrently with the growth and metastasis of tumors in-vivo. 36348379 hsa_circ_0090049 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Interaction(miR-605-5p or miR-548c-3p/UBE2T ) qRT-PCR Circ_0090049 and UBE2T were upregulated in liver cancer. MiR-605-5p and miR-548c-3p were identified as targets of circ_0090049, and UBE2T was the target of miR-605-5p and miR-548c-3p. Anti-miR-605-5p, anti-miR-548c-3p or UBE2T overexpression restored the inhibitory effect of circ_0090049 knockdown on HCC cells. Yes Silencing circ_0090049 reduced the proliferation, migration, invasion, and tumor spheroid formation rate of Huh7 and HCCLM3 cells. Animal experiments confirmed the antitumor effect of silence circ_0090049. 34620742 hsa_circ_0061395 CircRNA Homo sapiens Carcinoma, Hepatocellular liver cancer tissues and cells Interaction( miR-1182 sponge) qRT-PCR Circ_0061395 and SPOCK1 were significantly expressed in liver cancer tissues and cells. MiR-1182 was a target of circ_0061395. Silencing circ_0061395 inhibited the malignant behavior of HCC cells by releasing miR-1182. In addition, SPOCK1 was the target of miR-1182. Overexpression of SPOCK1 partially restored the inhibitory effect of miR-1182 on cell proliferation. Yes Silencing circ_0061395 reduced the proliferation, migration, invasion, tube formation and tumor spheroid formation rate of Huh-7 and SNU-387 cells. Animal experiments confirmed the anti-tumor effect of silence circ_0061395. Circ_0061395 induced the changes of the expression of SPOCK1 by regulating miR-1182, thereby mediating the process of HCC, and at least partially promoting the development of HCC cells, providing a novel targeted therapy for HCC. 35775884 circMAP3K4 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Expression(highly expressed) qRT-PCR We found circMAP3K4 to be an upregulated circRNA with coding potential in HCC. IGF2BP1 recognized the circMAP3K4 N6-methyladenosine modification and promoted its translation into circMAP3K4-455aa. Functionally, circMAP3K4-455aa prevented cisplatin-induced apoptosis in HCC cells by interacting with AIF, thus protecting AIF from cleavage and decreasing its nuclear distribution. Moreover, circMAP3K4-455aa was degraded through the ubiquitin-proteasome E3 ligase MIB1 pathway. Clinically, a high level of circMAP3K4 is an independent prognostic factor for adverse overall survival and adverse disease-free survival of HCC patients. Yes Functionally, circMAP3K4-455aa prevented cisplatin-induced apoptosis in HCC cells by interacting with AIF, thus protecting AIF from cleavage and decreasing its nuclear distribution. 35366894 circTOLLIP CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Interaction(miR-516a-5p/PBX3/EMT pathway) qRT-PCR circTOLLIP was significantly upregulated in HCC cells and tissues. Mechanistically, EIF4A3 promoted the biogenesis of circTOLLIP without affecting its stability. Moreover, circTOLLIP sponged miR-516a-5p to elevate the expression of PBX3, thereby activating the epithelial-to-mesenchymal transition (EMT) pathway and facilitating tumor progression in HCC. High circTOLLIP expression was correlated with poor overall survival (OS) and disease-free survival (DFS) in patients. Yes circTOLLIP promoted the proliferation and metastasis of HCC cells in vitro and in vivo. 35509064 circRASSF5 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-331-3p/PHLPP) qRT-PCR CircRASSF5 is obviously downregulated in both HCC tissues and cell lines. Mechanistically, circRASSF5 directly interacts with miR-331-3p as a sponge, and then enhances the expression of PH domain and leucine-rich repeat protein phosphatase (PHLPP), thus restraining the progression of HCC cells. Low level of circRASSF5 is negatively associated with larger tumor size, severe vascular invasion, more portal vein tumor embolus and unfavorable prognosis. Yes Loss-of-function assay reveals that circRASSF5 remarkably impedes the growth and metastasis of HCC cells in vitro and in vivo. 36217445 circCFH CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(circ-CFH/miR-377-3p/RNF38 axis) qRT-PCR circ-CFH was overexpressed in HCC tissues and cells, and the downregulation of circ-CFH inhibited the development of HCC by repressing cell proliferation, migration, invasion, and glycolysis while enhancing apoptosis in vitro, as well as inhibited tumor growth in vivo. miR-377-3p was negatively regulated by circ-CFH, and silencing of miR-377-3p abolished circ-CFH knockdown-mediated effects on HCC cells. Moreover, overexpression of miR-377-3p could impede the HCC process by targeting RNF38. Mechanistically, the circ-CFH/miR-377-3p/RNF38 axis regulated the progression of HCC cells, which might provide new diagnostic markers for HCC. Yes circ-CFH was overexpressed in HCC tissues and cells, and the downregulation of circ-CFH inhibited the development of HCC by repressing cell proliferation, migration, invasion, and glycolysis while enhancing apoptosis in vitro, as well as inhibited tumor growth in vivo. 35415236 hsa_circ_0058051 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Expression(highly expressed) qRT-PCR We found that high circ_0058051 expression was negatively correlated with the prognosis of HCC patients. Circ_0058051 knockdown attenuated the proliferation and colony formation, meanwhile inhibited migration of HCC cells. We found that high circ_0058051 expression was negatively correlated with the prognosis of HCC patients. Yes Circ_0058051 knockdown attenuated the proliferation and colony formation, meanwhile inhibited migration of HCC cells. 36114310 hsa_circ_0000285 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines and tumors Interaction( miR-582-3p/CCNB2 axis) qRT-PCR Elevated hsa_circ_0000285 and CCNB2 expressions, and a decreased miR-582-3p expression were observed among the HCC cell lines and tumors. Hsa_circ_0000285 bound to miR-582-3p competitively to improve CCNB2 levels. Inhibiting hsa_circ_0000285 or CCNB2 reversed the miR-582-3p-knockdown-mediated promotion of malignant HCC cell phenotypes. Yes Silencing of hsa_circ_0000285 promoted apoptosis and repressed proliferation and migration among HCC cells. Moreover, silencing hsa_circ_0000285 also impeded the growth of HCC tumors in vivo. 35839486 circSOD2 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-497-5p/ANXA11 Axis) qRT-PCR CircSOD2 was upregulated in HCC tissues and cells.Mechanically, circSOD2 promoted HCC development by acting as a miR-497-5p sponge and miR-497-5p played a tumor-inhibitory role in HCC cells by targeting ANXA11. Moreover, circSOD2 induced upregulation of ANXA11 expression by interacting with miR-497-5p. Also, the promoting effects of circSOD2 on immune evasion and anti-PD-1 resistance were related to miR-497-5p/ANXA11 axis. Yes Knockdown of circSOD2 resulted in HCC cell growth inhibition, apoptosis promotion, cell cycle arrest and metastasis suppression. 36008700 circLIFR CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(TBK1) qRT-PCR Among them, circRNA derived from the LIFR gene, named circLIFR, was significantly downregulated in HCC. RNA pull-down and mass spectrometry detection revealed circLIFR interacting with TANK binding kinase 1 (TBK1). Anti-TBK1 RIP confirmed the interaction between circLIFR and TBK1. TBK1 is a serine/threonine kinase that regulates several signaling pathways, including the NF-κB pathway. TBK1 inhibitors inhibit NF-κB activation. Overexpression of circLIFR overcame the in-hibitory function of TBK1, resulting in the upregulation of several genes, including MMP13, MMP3, VEGF, and MAPK. Yes Intriguingly, circLIFR overexpression in SK-Hep-1 cells promoted cell growth and invasion. 36176304 circGSE1 CircRNA Homo sapiens Carcinoma, Hepatocellular (HCC) cells Interaction( miR-324-5p/TGFBR1/Smad3 axis) qRT-PCR Collectively, we revealed that exosomal circGSE1 derived from hepatocellular carcinoma (HCC) cells promotes the progression of HCC by inducing Tregs expansion via regulating the miR-324-5p/TGFBR1/Smad3 axis. Yes In vivo animal metastasis models and bioluminescence imaging were used to verify the effect of exosomal circGSE1 on tumor progression. Collectively, we revealed that exosomal circGSE1 derived from hepatocellular carcinoma (HCC) cells promotes the progression of HCC by inducing Tregs expansion via regulating the miR-324-5p/TGFBR1/Smad3 axis. 35396771 circTTLL5 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-136-5p/KIAA1522 axis) qRT-PCR CircTTLL5 was incorporated into exosomes and highly expressed in HCC tissues and cells. Mechanically, circTTLL5 could sponge miR-136-5p, which controlled its down-stream target KIAA1522. MiR-136-5p inhibition reversed the effects of circTTLL5 knockdown on HCC cells. Besides that, miR-136-5p re-expression inhibited HCC cell growth and metastasis, which was abated by KIAA1522 overexpression. Yes CircTTLL5 knockdown suppressed HCC cell proliferation and metastasis in vitro and impeded tumor growth in mice. CircTTLL5 could be delivered to recipient cells via exosomes, and treatment of circTTLL5-elevated exosomes could attenuate the anticancer effects of circTTLL5 knockdown on HCC in vitro and in vivo. 36528986 circSYPL1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines Interaction(miR-506-3p/EZH2 ) qRT-PCR circSYPL1 expression was significantly upregulated in HCC cell lines, in addition to primary and metastatic tumors of patients with HCC. circSYPL1 sponged miR-506-3p to boost EZH2 expression levels, as indicated by luciferase and RNA pull-down assays. Furthermore, circSYPL1 overexpression could upregulate EZH2 expression, while miR-506-3p mimics or EZH2 shRNAs could reverse the circSYPL1-induced malignancy of HCC cells. Yes Additionally, it may promote HCC initiation, development as well as progression. By knocking down circSYPL1 siRNA, we were able to drastically decrease the aggressiveness of HCC cells. 35345511 circTMEM181 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-519a-5p/ARHGAP29 ) qRT-PCR In this study, we identified a novel circRNA, named circTMEM181, was downregulated in HCC tissues. CircTMEM181 overexpression reduced HCC cell migration and invasion abilities, while circTMEM181 knockdown increased cell motility. Mechanically, circTMEM181 could directly bind to miR-519a-5p and subsequently upregulate ARHGAP29 protein expression. Decreased expression of circTMEM181 was associated with shorter overall survival of patients with HCC. Yes CircTMEM181 overexpression reduced HCC cell migration and invasion abilities, while circTMEM181 knockdown increased cell motility. 36519254 hsa_circ_0006404 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC specimens and cells Interaction(miR-624) qRT-PCR Our data indicated that circ_0006404 was overexpressed in HCC specimens and cells and ectopic expression of circ_0006404 increased HCC cell growth, cycle, and migration.Moreover, we showed that miR-624 was downregulated in HCC specimens and cells and miR-624 expression was negatively correlated with circ_0006404 expression in HCC specimens. Circ_0006404 sponged miR-624 in HCC cell, and the overexpression of circ_0006404 suppressed miR-624 expression in HCC cell. Furthermore, circ_0006404 induced HCC cell growth, cycle, and migration via regulating miR-624. Yes Our data indicated that circ_0006404 was overexpressed in HCC specimens and cells and ectopic expression of circ_0006404 increased HCC cell growth, cycle, and migration. 35579835 circKIF5B CircRNA Homo sapiens Carcinoma, Hepatocellular liver cancer cell lines and tissues Interaction(miR-192 Family/XIAP Axis) qRT-PCR Importantly, we found that circKIF5B circRNA, rather than KIF5B linear mRNA, was notably upregulated in liver cancer cell lines and tissues. Moreover, we found that silencing circKIF5B markedly reduced the proliferation, invasion, and metastasis of liver cancer cells by sponging the miR-192 family, thus decreasing the expression of X-linked inhibitor of apoptosis (XIAP). Yes Moreover, we found that silencing circKIF5B markedly reduced the proliferation, invasion, and metastasis of liver cancer cells by sponging the miR-192 family, thus decreasing the expression of X-linked inhibitor of apoptosis (XIAP). 35847962 circEIF3I CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-526b-5p Axis) qRT-PCR Expression of circEIF3I was upregulated in HCC tissues. CircEIF3I could sponge miR-526b-5pto regulate downstream HGF. Functionally, circEIF3I regulation in HCC cell progression was associated with miR-526b-5p sponging function and HGF upregulation could attenuate tumor-inhibiting roles of miR-526b-5p. HCC tumor growth was delayed by interfering circEIF3I. Yes Knockdown of circEIF3I suppressed cell proliferation epithelial-mesenchymal transition, migration, invasion and tube formation ability but promoted apoptosis of HCC cells. 35723810 hsa_circ_0073181 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-548p/ PTPRE axis) qRT-PCR Circ_0073181 and PTPRE were upregulated, and miR-548p was decreased in HCC tissues and cells. Circ_0073181 silencing could inhibit HCC cell growth and metastasis partly by regulating the miR-548p/ PTPRE axis, providing a promising therapeutic target for the HCC treatment. Yes Furthermore, circ_0073181 knockdown could boost proliferation, migration, invasion and repress apoptosis of HCC cells in vitro. The mechanical analysis suggested that circ_0073181 could regulate PTPRE expression by sponging miR-548p. In addition, circ_0073181 knockdown suppressed cell growth of HCC in vivo. 34657099 hsa_circ_0006789 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-1324 and SOX12) qRT-PCR Circ_0006789 was overexpressed in HCC tissues and cell lines. miR-1324 was confirmed as a target of circ_0006789, and miR-1324 targeted SOX12 to suppress its expression. Circ_0006789 could promote SOX12 expression by sponging miR-1324. Yes Circ_0006789 overexpression accelerated the growth, migration and invasion of HCC cells, while knockdown of circ_0006789 exerted the opposite effects. 36017856 hsa_circ_0036412 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(ELAVL1/GLI2 ) qRT-PCR Circ_0036412 is overexpressed in HCC cells and features circular structure. Circ_0036412 modulates Hedgehog pathway. GLI2 propels HCC growth in vivo. Circ_0036412 up-regulates GLI2 expression by competitively binding to miR-579-3p, thus promoting the proliferation and inhibiting cell cycle arrest of HCC cells. Circ_0036412 stabilizes GLI2 expression by recruiting ELAVL1. Circ_0036412 propels the proliferation and inhibits cell cycle arrest of HCC cells in vitro through Hedgehog pathway. Yes PRDM1 activates circ_0036412 transcription to regulate the proliferation and cell cycle of HCC cells in vitro. 35382824 hsa_circ_0004658 CircRNA Homo sapiens Carcinoma, Hepatocellular Mφ-Exo Interaction(miR-499b-5p/JAM3) qRT-PCR Our results shown that hsa_circ_0004658 is upregulated in RBPJ+/+ Mφ-Exo compared to WT Mφ-Exo. The effects of RBPJ+/+ Mφ-Exo on HCC cells can be reversed by the hsa_circ_0004658 knockdown. Mechanistic investigations revealed that hsa_circ_0004658 acts as a ceRNA of miR-499b-5p, resulting in the de-repression of JAM3. Yes RBPJ+/+ Mφ-Exo and hsa_circ_0004658 inhibits proliferation and promotes apoptosis in HCC cells, whereas hsa_circ_0004658 knockdown stimulated cell proliferation and migration but restrained apoptosis in vitro and promotes tumor growth in vivo. 35013102 hsa_circ_0064288 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-335-5p/ROCK1 ) qRT-PCR Circ_0064288 and ROCK1 expression was up-modulated in HCC, while miR-335-5p was down-modulated. Additionally, circ_0064288 could competitively bind with miR-335-5p thereby up-modulate ROCK1 expression. MiR-335-5p overexpression partly counteracted the effect of circ_0064288 overexpression on HCC cells. High circ_0064288 expression was associated with shorter survival time of HCC patients. Yes It was also revealed that circ_0064288 overexpression remarkably enhanced HCC cell growth and migration, while knockdown of circ_0064288 induced opposite effects. 35287604 circRPN2 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines and HCC tissues Interaction(miR-183-5p/FOXO1 axis) circRNA-seq CircRPN2 was downregulated in highly metastatic HCC cell lines and HCC tissues with metastasis.These data support a model wherein circRPN2 inhibits HCC aerobic glycolysis and metastasis via acceleration of ENO1 degradation and regulation of the miR-183-5p/FOXO1 axis, suggesting that circRPN2 represents a possible therapeutic target in HCC. Patients with HCC with lower circRPN2 levels displayed shorter overall survival and higher rates of cumulative recurrence. Yes Mechanistic studies in vitro and in vivo revealed that circRPN2 binds to enolase 1 (ENO1) and accelerates its degradation to promote glycolytic reprogramming through the AKT/mTOR pathway, thereby inhibiting HCC metastasis. 35045986 circCCNB1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and cancer tissues Interaction(miR-106b-5p/GPM6A ) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay The expression of circCCNB1 and GPM6A were significantly down-regulated in HCC cells and cancer tissues, while miR-106b-5p expression was up-regulated. We demonstrated that circCCNB1 silencing promoted cell proliferation and metastasis of HCC cells by weakening sponging of oncogenic miR-106b-5p to induce GPM6A underexpression. DYNC1I1 gene expression was up-regulated and further led to activation of the AKT/ERK signaling pathway. Yes In addition, circCCNB1 silencing promoted the clone formation ability, the cell cycle G1-S transition, and the growth of xenograft tumors of HCC cells via GPM6A downregulation. 35002514 hsa_circ_0008194 CircRNA Homo sapiens Carcinoma, Hepatocellular tumor tissues Interaction(miR-190a/AHNAK ) RNA Pull-Down//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay In this study, the abnormal upregulated circ_0008194 in tumor tissues was detected. The positive correlation between circ_0008194 and AHNAK was also confirmed. Mechanically, circ_0008194 presented the binding ability with miR-190a causing the suppression of miR-190a expression, causing the competitive inhibition of AHNAK, resulting in the promotion of EMT. Yes Through knockdown and overexpression of circ_0008194, we conducted in vitro functional studies. We found circ_0008194 could induce the invasion of cells in vitro. 35199873 hsa_circ_0000098 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction( miR-383/MCUR1 axis) Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//cell invasion assay The expression of circ_0000098 was higher in HCC tissues compared to paired adjacent tissues. Furthermore, mechanistic investigation demonstrated that by sequestering miR-383 from the 3'-UTR of MCUR1, circ_0000098 positively regulated MCUR1 expression in HCC cells and finally promoted HCC progression. On the other hand, inhibiting circ_0000098 in HCC cells could diminish doxorubicin (DOX) resistance by decreasing P-glycoprotein (P-gp, MDR1) expression and intracellular ATP levels. Yes Our experiments indicated that circ_0000098 served as a key oncogenic circRNA to increase HCC cell proliferation and invasion in vitro and HCC progression in vivo. 36071480 hsa_circ_0005397 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-1283/HEG1) qRT-PCR Circ_0005397 was highly expressed in HCC tissues and cells, in HCC cell lines. Yes Circ_0005397 silencing inhibited proliferation, migration, invasion and angiogenesis, while induced apoptosis in HCC cells. 35500803 hsa_circ_0001459 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue and cell lines. Interaction(miR-6165/IGF1R axis) qRT-PCR We found that circ_0001459 expression was significantly elevated in HCC tissue and cell lines. Mechanistically, we revealed that circ_0001459 could sponge miR-6165 and induce the upregulation of its downstream target IGF1R, thus significantly promoting the progression of HCC. Yes . Knockdown of circ_0001459 significantly inhibited the proliferation, migration, and invasion of HCC cells, whereas upregulation of circ_0001459 had the opposite effect. 35199365 circKCNN2 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-520c-3p/MBD2 axis) qRT-PCR The expression of circKCNN2 was downregulated in HCC tissues and predicted a favorable overall survival and recurrence-free survival. The expression of circKCNN2 was positively correlated with the parental gene, potassium calcium-activated channel subfamily N member (KCNN2). Nuclear transcription factor Y subunit alpha (NFYA) was proven to inhibit the promoter activity of KCNN2, downregulate the expression of KCNN2 and circKCNN2, and predict an unfavorable recurrence-free survival. miR-520c-3p sponged by circKCNN2 could reverse the inhibitory effect of circKCNN2 on HCC cells and down-regulate the expression of methyl-DNA-binding domain protein 2 (MBD2). The expression of circKCNN2 was downregulated in HCC tissues and predicted a favorable overall survival and recurrence-free survival. Yes Ectopic expression of circKCNN2 inhibited HCC cell proliferation, colony formation, migration, and tumor formation in a mouse model. 35051313 circPAK1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues and cell lines Interaction( 14-3-3 ζ with YAP) qRT-PCR CircPAK1, a novel circRNA, is highly expressed in HCC tumor tissues and cell lines as well as correlated with poor outcomes in HCC patients. Mechanistically, circPAK1 enhanced HCC progression by inactivating the Hippo signaling pathway, and this kind of inactivation is based on its competitively binding of 14-3-3 ζ with YAP, which weakens the recruitment and cytoplasmic fixation of 14-3-3 ζ to YAP, thus promoting YAP nucleus localization. CircPAK1, a novel circRNA, is highly expressed in HCC tumor tissues and cell lines as well as correlated with poor outcomes in HCC patients. Yes Functionally, circPAK1 knockdown inhibited HCC cell proliferation, migration, invasion and angiogenesis while circPAK1 overexpression promoted HCC progression. The tumor-promoting phenotypes of circPAK1 on HCC were also confirmed by animal experiments. Importantly, the application of CS/si-circPAK1 nanocomplexes showed a better therapeutic effect on tumor growth and metastasis. 36131287 circPTTG1IP CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-16-5p/RNF125/JAK1 axis) qRT-PCR CircPTTG1IP expression was decreased in HCC compared to peritumoral tissues. Mechanistically, circPTTG1IP was shown to function as a competing endogenous RNA (ceRNA) of RNF125 by binding miR-16-5p to increase the level of the E3 ubiquitin ligase RNF125, which further ubiquitinated and degraded JAK1 protein. Finally, we demonstrated that administration of filgotinib, a JAK1 inhibitor, restricted HCC progression induced by low circPTTG1IP expression. Moreover, low circPTTG1IP expression was revealed to be associated with a poor prognosis of HCC patients. Yes Elevation of circPTTG1IP was revealed to inhibit HCC development both in vitro and in vivo. 35710093 circCPSF6 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC specimens and cells Interaction(PCBP2/YAP1) qRT-PCR Meanwhile, circCPSF6 was upregulated in HCC specimens, and elevated circCPSF6 expression served as an independent prognostic factor for worse survival of patients with HCC. circCPSF6 triggered expression of YAP1, further activating its downstream cascade. Mechanistically, circCPSF6 competitively bound PCBP2, blunting its binding to YAP1 mRNA, thereby sustaining the stability of YAP1. Meanwhile, circCPSF6 was upregulated in HCC specimens, and elevated circCPSF6 expression served as an independent prognostic factor for worse survival of patients with HCC. Yes Loss-of-function assays demonstrated that circCPSF6 maintained cell proliferation and tumorigenicity and reinforced cell motility and tumor metastasis. Functionally, removal of YAP1 reversed the effects of circCPSF6 in vitro and in vivo. 34916222 hsa_circ_0040705 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and HCC cells Interaction( miR-557/SOX2 ) Western Blot//CCK8//qRT-PCR//Bioinformatics Analysis//Transwell Assay The expression levels of circ_0040705 and SOX2 mRNA were markedly increased in HCC tissues, but miR-557 expression was down-regulated. Circ_0040705 worked as a sponge for miR-557 to down-modulate miR-557 expression, and miR-557 could specifically down-modulate SOX2 expression. Yes Circ_0040705 overexpression enhanced the growth, migration, invasion, and the expressions of E-cadherin and N-cadherin of HCC cells and promoted lung metastasis in vivo, whereas circ_0040705 knockdown exerted the opposite effects in HCC cells. 35080329 hsa_circ_0051040 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-569/ITGAV ) qRT-PCR In this study, we found that hsa_circ_0051040 was overexpressed in HCC tissues and cell lines and that its expression was correlated with poor prognosis. Moreover, our data demonstrated that hsa_circ_0051040 acted as a sponge for miR-569 to regulate ITGAV expression and induce EMT progression. In this study, we found that hsa_circ_0051040 was overexpressed in HCC tissues and cell lines and that its expression was correlated with poor prognosis. Yes Knockdown of hsa_circ_0051040 inhibited the migration, invasion, and proliferation of HCC cells in vitro and in vivo, whereas overexpression of hsa_circ_0051040 had the opposite effects. 36429000 circMDK CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-346/874-3p-ATG16L1 ) Bioinformatics Analysis Hsa_circ_0095868, derived from exon 5 of the MDK gene (named circMDK), was identified as a new oncogenic circRNA that was significantly upregulated in HCC. Mechanistically, circMDK sponged miR-346 and miR-874-3p to upregulate ATG16L1 (Autophagy Related 16 Like 1), resulting to the activation of PI3K/AKT/mTOR signaling pathway to promote cell proliferation, migration and invasion. The upregulation of circMDK was associated with the modification of N6-methyladenosine (m6A) and poor survival in HCC patients. Yes Mechanistically, circMDK sponged miR-346 and miR-874-3p to upregulate ATG16L1 (Autophagy Related 16 Like 1), resulting to the activation of PI3K/AKT/mTOR signaling pathway to promote cell proliferation, migration and invasion. 35524319 hsa_circ_0067835 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues and HCC cell lines Interaction(miR-1236-3p/Twist2 Axis) qRT-PCR In this study, our results of microarray and real-time PCR (RT-PCR) showed that it was obviously elevated in human HCC tumor tissues and HCC cell lines. Inhibition of circ_0067835 restrained cell proliferation and migration in vitro. Furthermore, miR-1236-3p was decreased in tumor samples, and it was indicated to be a target of circ_0067835. Moreover, Twist2 was established to be elevated in HCC tissues, and we identified it as the direct target of miR-1236-3p. Finally, we found that knockdown of miR-1236-3p could reverse the circ_0067835 inhibition effects in HCC cells. In conclusion, our study demonstrated that circ_0067835 contributed to promoting hepatocellular carcinoma cell proliferation and metastasis through downregulating miR-1236-3p expression and then elevating Twist2 expression, which might provide a new vision for HCC patients. Yes Inhibition of circ_0067835 restrained cell proliferation and migration in vitro. 36262967 circGPR137B CircRNA Homo sapiens Carcinoma, Hepatocellular HCC and adjacent normal tissues Interaction(CircGPR137B/miR-4739/FTO feedback loop) qRT-PCR We identified a new dramatically downregulated circGPR137B in HCC tissues, and found that downregulation of circGPR137B or upregulation of miR-4739 was associated with poor prognosis in patients with HCC. Ectopic expression of circGPR137B strikingly repressed the proliferation, colony formation and invasion, whereas knockdown of circGPR137B harbored the opposite effects. Moreover, restored expression of circGPR137B inhibited tumor growth and lung metastasis in vivo. Further investigations showed that circGPR137B, co-localized with miR-4739 in the cytoplasm, acted as a sponge for miR-4739 to upregulate its target FTO, which mediated m6A demethylation of circGPR137B and promoted its expression. Thus, a feedback loop comprising circGPR137B/miR-4739/FTO axis was formed. FTO suppressed cell growth and indicated favorable survival in patients with HCC. FTO suppressed cell growth and indicated favorable survival in patients with HCC.We identified a new dramatically downregulated circGPR137B in HCC tissues, and found that downregulation of circGPR137B or upregulation of miR-4739 was associated with poor prognosis in patients with HCC. Yes Ectopic expression of circGPR137B strikingly repressed the proliferation, colony formation and invasion, whereas knockdown of circGPR137B harbored the opposite effects. 35858900 circSETD2 CircRNA Homo sapiens Carcinoma, Hepatocellular liver cancer tissues Expression(lower expressed) Bioinformatics Analysis This study found that circular RNA circ SET domain containing 2 (circSETD2) is abnormally expressed in liver cancer tissues, but the role and molecular mechanismsin the occurrence and development of liver cancer are still unclear. The expression level of circSETD2 was evaluated through Quantitative Real-time Polymerase chain reaction (qRT-PCR) in cancerous liver tissues (30 cases), liver cancer cell lines and para-cancerous tissues. Knockdown and overexpression circSETD2 lentiviral vector was constructed and applied to transfect hepatoma cells. Cell Counting Kit-8 (CCK-8), colony formation assay, flow cytometry and Transwell assay were used to examine the effects of circSETD2 overexpression or knockdown on liver cancer migration, invasion, cell cycle and cell proliferation. The tumourigenicity in vivo was utilized to assess the effect of circSETD2 on the proliferation of liver cancer cells. circSETD2 expression is lower in cell lines and liver cancer tissues. circSETD2 knockdown can considerably increase liver cancer cells' invasion, proliferation and colony formation. While In vitro and in vivo, circSETD2 overexpression shows opposite effect. Western blot showed that circSETD2 knockdown can considerably promote E-cadherin expression and inhibit Vimentin, N-cadherin, matrix metallopeptidase-9 (MMP-9) and MMP-2 expression. Yes circSETD2 knockdown can considerably increase liver cancer cells' invasion, proliferation and colony formation. While In vitro and in vivo, circSETD2 overexpression shows opposite effect. 35260047 hsa_circ_0008583 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-1301-3p/METTL3 pathway) qRT-PCR Our data showed that hsa_circ_0008583 was upregulated in HCC tissues and cells. MiR-1301-3p is directly bound to hsa_circ_0008583 and METTL3. MiR-1301-3p overexpression or METTL3 knockdown could partially counteract hsa_circ_0008583 overexpression-mediated influence on HCC cell behaviors. In addition, hsa_circ_0008583 depletion inhibits HCC tumor growth in vivo. In conclusion, hsa_circ_0008583 promotes HCC progression through the miR-1301-3p/METTL3 axis. Yes Hsa_circ_0008583 overexpression promoted Hep3B cell proliferation, migration and invasion, but hsa_circ_0008583 silencing had an opposing influence. 35258395 circACTG1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Interaction(miR-940/RIF1 Axis /miR-940/RIF1 Axis ) qRT-PCR circACTG1 was overexpressed in HCC cells and tissues. Significantly, circACTG1 was discovered to serve as a miR-940 sponge. miR-940 activation rebated the circACTG1 level, and conversely, miR-940 inhibition boosted the circACTG1 level. However, this effect or relationship was not seen after circACTG1 mutation. Furtherly, miR-940-downregulated expression was also found in HCC patients, and importantly, miR-940 inhibition reversed circACTG1 expression in 97H cells with circACTG1 knockdown. Moreover, the expression of RIF1 was significantly reduced after inhibiting circACTG1 or overexpressing miR-940 but rescued when both circACTG1 and miR-940 were inhibited. Finally, circACTG1 and miR-940 played significant roles of regulating AKT-mTOR signaling. Yes Knockdown of circACTG1 restrained 97H and Huh7 cell migration and invasion. 35769514 circZEB1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-199a-3p/PIK3CA ) qRT-PCR Circ-ZEB1 and PIK3CA were upregulated in HCC and predicted a poor prognosis. MiR-199a-3p blocked the effect of circ-ZEB1 on HCC. Circ-ZEB1 served as a biomarker of HCC. Circ-ZEB1 promoted the expression of PIK3CA by silencing miR-199a-3p to affect the progress of HCC. Circ-ZEB1 and PIK3CA were upregulated in HCC and predicted a poor prognosis. Yes MiR-199a-3p showed low expression in HCC, whereas downregulation of circ-ZEB1 reduced HCC cell proliferation and promoted cell apoptosis. 35277182 circSEC24A CircRNA Homo sapiens Carcinoma, Hepatocellular HCCLM3 and Hep3B cells Interaction(miR-421/MMP3 axis) qRT-PCR circSEC24A expression was significantly upregulated in HCCLM3 and Hep3B cells. Meanwhile, MMP3 could bind to miR-421 to decrease the functional effects of miR-421 and induce tumor metastasis. circSEC24A interference suppressed HCC cell EMT by sponging miR-421, further regulating MMP3, and inhibiting tumor growth in vivo. Yes Silencing circSEC24A mitigated the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of HCC cells, which was abrogated by downregulation of miR-421. Knockdown of cicSEC24A suppressed tumor growth in vivo. 35400271 circUBAP2 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cell lines regulation[ miR-382-5p/PRPF8 axis] qRT-PCR circRNA-UBAP2 was upregulated in ovarian cancer tissues and cell lines. circRNA-UBAP2 acted as a ceRNA to sponged miR-382-5p, increased the expression level of PRPF8, and prompted proliferation and inhibited apoptosis in ovarian cancer cells. Yes Knockdown of circRNA-UBAP2 inhibited cell proliferation and promoted cell apoptosis, but circRNA-UBAP2 overexpressed got opposite results. 32690086 hsa_circ_9119 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines regulation[microRNA-21-5p-PTEN-Akt pathway] qRT-PCR//Luciferase Report Assay The expression of circ9119 was clearly reduced in OC tissues and cell lines, whereas the microRNA-21-5p (miR-21) levels were elevated compared with those in normal healthy control tissues and immortalized fallopian epithelial cell line FTE187. Thus, circ9119 could regulate cell proliferation and apoptosis of OC cells via by acting as an miR-21 sponge and targeting the PTEN-Akt pathway. Yes Further, circ9119 was overexpressed, causing a notable decrease in the viability and proliferation of OC cells and an increase in apoptosis. 32675386 circFGFR3 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cells regulation[miR-29a-3p/E2F1 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our results showed that circFGFR3 expression was higher in OC cells and tissues than in normal ovarian cells and adjacent normal tissues; Therefore, circFGFR3 serves as a promoter of OC by inducing OC cell EMT via the miR-29a-3p/E2F1 axis and circFGFR3 may be a prognostic biomarker for OC patients. Our results showed that circFGFR3 expression was higher in OC cells and tissues than in normal ovarian cells and adjacent normal tissues; in addition, in OC patients, a high level of CircFGFR3 was related to lower survival rates and higher recurrence rates than a low level of circFGFR3. Yes CircFGFR3 overexpression promotes OC progression by inducing epithelial-mesenchymal transition (EMT) in vitro. 32668414 circCELSR1 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer cells regulation[miR-598 ,BRD4 ] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Colony Formation Assay//Transwell Assay circCELSR1 and BRD4 were promoted, but miR-598 was suppressed in various ovarian cancer cells. Knockdown of circCELSR1 inhibited BRD4-mediated proliferation/migration related signaling via sponging miR-598, thereby repressing ovarian cancer progression. Yes Knockdown of circCELSR1 suppressed proliferation, migration, invasion and epithelial-mesenchymal transition (EMT), but promoted apoptosis in ovarian cancer cells, and these effects were reversed by miR-598 inhibition or BRD4 overexpression. 32640974 hsa_circ_0009910 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues regulation[miR-145 ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Hsa_circ_0009910, representing unfavorable prognosis, induced proliferative and motile phenotypes by suppressing miR-145 in ovarian cancer cells. Yes The ovarian cancer cell phenotypes were promoted by hsa_circ_0009910 while repressed by silencing hsa_circ_0009910. 32588730 hsa_circ_102958 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines regulation[miR-1205/SH2D3A Axis] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay hsa_circRNA_102958 was upregulated in OC tissues and cell lines.Our data suggest that hsa_circRNA_102958 promotes OC aggravation through regulation of miR-1205/SH2D3A signaling. hsa_circRNA_102958 upregulation indicated a poor prognosis in OC patients. Yes Knockdown of hsa_circRNA_102958 significantly suppressed the proliferation, migration and invasion of OC cells and vice versa. 32547237 hsa_circ_0078607 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues regulation[miR-518a-5p/Fas signaling pathway] qRT-PCR//Luciferase Report Assay In the present study, we first found that circ_0078607 was downregulated in ovarian cancer. The results of the present study revealed that circ_0078607 suppressed ovarian cancer progression by sponging oncogenic miR-518a-5p to induce Fas expression, which may provide new therapeutic approach for ovarian cancer. Yes Forced circ_0078607 expression significantly suppressed proliferation and promoted apoptosis of ovarian cancer cells. 32503653 circMYLK CircRNA Homo sapiens Ovarian Neoplasms OC tissue regulation[microRNA-652] CCK8//qRT-PCR//Luciferase Report Assay qPCR results indicated that circRNA_MYLK level in OC patients was remarkably higher than that in adjacent ones, and the difference was statistically significant. CircRNA_MYLK may promote the malignant progression of OC via regulating microRNA-652, and its expression was remarkably associated with pathological staging and poor prognosis in patients with OC. Compared with patients with low expression of circRNA_MYLK, patients with high expression of circRNA_MYLK had a higher pathological staging and a lower overall survival rate. Yes Compared with the control group (sh-NC), the OC cell proliferation ability was remarkably attenuated in the circRNA_MYLK knockdown group (sh-circRNA). 32495861 hsa_circ_0004390 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues regulation[miR-198/MET axis] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay We further identified one circRNA derived from the LPAR3 gene and termed Circ0004390, which was frequently upregulated in ovarian cancer tissues. Our findings suggested that Circ0004390 regulated ovarian cancer proliferation by miR-198/MET axis, which might provide a potential target for the treatment of ovarian cancer. Yes The knockdown of Circ0004390 can significantly reduce the proliferation of ovarian cancer cells. 32192774 circPGAM1 CircRNA Homo sapiens Ovarian Neoplasms EOC tissues regulation[miR-542-3p/CDC5L/PEAK1 pathway] ChIP//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Circ-PGAM1 was upregulated in EOC tissues, whereas linear PGAM1 was not deregulated in EOC tissues.The circ-PGAM1/miR-542-3p/CDC5L/PEAK1 pathway played an important role in the progression of ovarian cancer and might be a novel therapeutic target for ovarian cancer. Yes Silencing of circ-PAGM1 inhibited proliferation, migration, and invasion of ovarian cancer cells and promoted cell apoptosis. 32167655 hsa_circ_0013958 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cells Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Hsa_circ_0013958 was highly expressed in ovarian cancer tissues and cells, and its expression was closely related to patient FIGO stage and lymph node metastasis. Hsa_circ_0013958 was highly expressed in ovarian cancer tissues and cells, and its expression was closely related to patient FIGO stage and lymph node metastasis. Yes Further, in vitro studies showed that knockdown of hsa_circ_0013958 suppressed proliferation, migration, and invasion of ovarian cancer cells but elevated the cell apoptotic rate. 32157748 hsa_circ_0007874 CircRNA Homo sapiens Ovarian Neoplasms OVA cell lines regulation[miR-760/SOCS3 pathway] qRT-PCR//Luciferase Report Assay//FISH Results verified that hsa_circ_0007874 is downregulated in OVA cell lines. In summary, the data suggest that hsa_circ_0007874 acts as a tumor suppressor by regulating the miR-760/SOCS3 axis, highlighting its potential as an effective therapeutic target for OVA. Yes hsa_circ_0007874 overexpression decreased the OVA cell migration and proliferation in vitro and in vivo. 32023009 hsa_circ_100395 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues regulation[miR-1228/p53/EMT axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The expression of circ_100395 was found to be significantly down-regulated in ovarian cancer, while low expression of circ_100395 was highly correlated with the poor outcomes.CircRNA_100395 could inhibit cell growth and metastasis of ovarian cancer cells via regulating the miR-1228/p53/EMT axis. The expression of circ_100395 was found to be significantly down-regulated in ovarian cancer, while low expression of circ_100395 was highly correlated with the poor outcomes. Yes In addition, upregulation of circ_100395 could significantly inhibit tumor growth, metastasis and EMT signaling pathway in ovarian cancer. 31942183 circLARP4 CircRNA Homo sapiens Ovarian Neoplasms ovarian epithelial cells regulation[miR-513b-5p/LARP4 axis] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of circ_LARP4 in OC cells was much lower than that in human normal ovarian epithelial cells. Circ_LARP4 could hamper cell proliferation and migration by sponging miR-513b-5p to regulate the expression of LARP4. Yes Overexpressing circ_LARP4 impaired cell proliferation, invasion and migration abilities. 31911757 circNFATC3 CircRNA Homo sapiens Ovarian Neoplasms cell lines  Regulation(up regulation) Migration Assay//CCK8//qRT-PCR//RNA-seq//Invasion Assay Breast and ovarian cancer cells showed a greater abundance of circNFATC3 compared to normal breast cell lines, lung fibroblast cells, and LCL cells. Yes The knockdown of circNFATC3 induces a reduction in cell proliferation, invasion, migration, and oxidative phosphorylation. Gain-of-function of circNFATC3 in MDA-MB-231 and SK-OV-3 cells show a significant increase in cell proliferation, migration, and respiration. 33816459 circRAB11FIP1 CircRNA Homo sapiens Ovarian Neoplasms epithelial ovarian cancer (EOC) tissues Interaction(miR-129/DSC1) FISH//Co-IP//EdU Staining//Western Blot CircRAB11FIP1 expression was elevated in epithelial ovarian cancer (EOC) tissues than in normal ovarian tissues. Also, circRAB11FIP1 directly bound to miR-129 and regulated its targets ATG7 and ATG14. Yes Silencing circRAB11FIP1 inhibited the autophagic flux of ovarian cancer SKOV3 cells. However, circRAB11FIP1 overexpression activated the autophagic flux of ovarian cancer A2780 cells. 33637694 circLOPD2 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer (OC) tissues Interaction(miR-378 ) CCK8//qRT-PCR//Luciferase Report Assay//Western Blot The results showed that circ-LOPD2 was highly expressed in ovarian cancer (OC) tissues, circ-LOPD2 expression levels were higher in OVCAR3 and A2780, and circ-LOPD2 expression levels in CAOV3 were lower. We also found that miR-378 is a target of circ-LOPD2. Silencing circ-LOPD2 will increase the expression of miR-378, and overexpression of circ-LOPD2 will decrease the expression of miR-378. Yes After silencing circ-LOPD2, the growth ability of OVCAR3 and A2780 cells decreased, while overexpression of circ-LOPD2 led to the opposite result. 34759745 hsa_circ_0000554 CircRNA Homo sapiens Ovarian Neoplasms ovarian tumor specimens and cells Interaction( miR-567) qRT-PCR//Luciferase Report Assay//Invasion Assay We illustrated that miR-567 was downregulated in ovarian tumor specimens and cells. circ_0000554 was negatively correlated with miR-567 in ovarian tumor specimens. circ_0000554 sponged miR-567 expression in ovarian tumor. RIP assay showed that elevated expression of miR-567 could be enriched with circ_0000554 Yes Elevated expression of circ_0000554 suppressed miR-567 expression in HO8910 cell. circ_0000554 promoted ovarian tumor cell growth, invasion, and EMT via sponging miR-567. 34709546 hsa_circ_0007841 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cell lines Interaction(miR-151-3p/MEX3C axis ) qRT-PCR//Luciferase Report Assay//RIP//Transwell Assay In the current study, it was found that circ_0007841 expression was upregulated in ovarian cancer tissues and cell lines. In terms of mechanism, circ_0007841 worked as a competing endogenous RNA (ceRNA) for miR-151-3p to facilitate MEX3C expression. Restoration of MEX3C level recovered the proliferation, migration and invasion of ovarian cancer cells. Upregulation of circ_0007841 in patients with ovarian cancer predicts poor prognosis. Yes Loss-of-function experiments discovered that circ_0007841 knockdown suppressed the proliferation, migration and invasion of ovarian cancer cells in vitro and in vivo. 33896797 circRHOBTB3 CircRNA Homo sapiens Ovarian Neoplasms regulation[PI3K/AKT signaling pathway] CCK8//qRT-PCR//Western Blot//Transwell Assay CircRHOBTB3 exerted a suppressor role and inhibited the tumorigenesis by inactivating PI3K/AKT pathway in ovarian cancer. Yes Functionally, circRHOBTB3 overexpression could markedly suppress cell proliferation, metastasis and glycolysis, whereas the opposite results could be observed in the deletion of circRHOBTB3. 32720791 circMTO1 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cell lines regulation[ miR-182-5p/KLF15 Axis] qRT-PCR We demonstrated that circMTO1 was downregulated in ovarian cancer tissues and cell lines. Mechanistically, we showed that circMTO1 sponged miR-182-5p to support KLF15 expression, eventually leading to inhibition of ovarian cancer progression. Yes Upregulation of circMTO1 inhibited proliferation and invasion of ovarian cancer cells while downregulation of circMTO1 promoted these processes. 32731816 circEXOC6B CircRNA Homo sapiens Ovarian Neoplasms cell lines regulation[ miR-421,RUS1 ] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot As shown in Figure 1A, the level of circEXOC6B was significantly decreased in SKOV3 and OVCAR3 cells, compared with that in IOSE80 cells. In this study, we found that circEXOC6B suppressed the growth of ovarian cancer cells through upregulating RSU1 partially via sponging miR-421. Yes Downregulation of circEXOC6B markedly promoted the proliferation and invasion in A2780 cells. In contrast, upregulation of circEXOC6B significantly inhibited the proliferation and invasion in SKOV3 cells. Moreover, overexpression of circEXOC6B obviously induced the apoptosis of SKOV3 cells. 32884301 circPLEKHM3 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Regulation[miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis] Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Transwell Assay CircPLEKHM3 was identified as one of the most significantly down-regulated circRNAs in ovarian cancer tissues compared with normal tissues. Further analyses showed that circPLEKHM3 sponged miR-9 to regulate the endogenous expression of BRCA1, DNAJB6 and KLF4, and consequently inactivate AKT1 signaling. In addition, AKT inhibitor MK-2206 could block the tumor-promoting effect of circPLEKHM3 depletion, and potentiate Taxol-induced growth inhibition of ovarian cancer cells. Yes Functionally, circPLEKHM3 overexpression inhibited cell growth, migration and epithelial-mesenchymal transition, whereas its knockdown exerted an opposite role. 31623606 hsa_circ_0003945 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue and cells Interaction(miR-34c-5p/LGR4/β-catenin axis activity) qRT-PCR In this study, we found that Circ_0003945 was upregulated in HCC tissue, and higher Circ_0003945 expression was positively correlated with tumour size and tumour stage. Furthermore, high plasma levels of circulating Circ_0003945 were confirmed in HCC patients compared with those in non-HCC groups. Mechanistically, Circ_0003945 might exert as a miR-34c-5p sponge to upregulate the expression of leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4), activating the β-catenin pathway, and finally facilitating HCC progression. Additionally, a β-catenin activator could reverse the effect of Circ_0003945 knockdown. In this study, we found that Circ_0003945 was upregulated in HCC tissue, and higher Circ_0003945 expression was positively correlated with tumour size and tumour stage. Yes The functional experiments revealed that overexpression or knockdown of Circ_0003945 promoted or attenuated tumour growth and migration, respectively. 35170199 circCBFB CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,. HCC cell Interaction(miR-424-5p/ATG14 axis) qRT-PCR In HCC tissues, circCBFB and ATG14 were highly expressed, and miR-424-5p expression was downregulated. miR-424-5p was a target gene of circCBFB, and miR-424-5p negatively mediated ATG14. CircCBFB inhibits miR-424-5p and upregulates ATG14, thus promoting HCC cell proliferation and autophagy. Yes Transfection of pcDNA3.1-CircCBFB, miR-424-5p inhibitor, or pcDNA3.1-ATG14 into HCC cells facilitated HCC cell proliferation and autophagy, while suppressing cell apoptosis, evidenced by elevated cell viability, increased protein levels of autophagosome markers (LC3-ΙΙ/LC3-Ι and Beclin1), repressed apoptosis rate, and suppressed protein level of autophagy receptor p62. 35066780 hsa_circ_0008934 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-1305/TMTC3 axis) qRT-PCR In this study, circ_0008934 expression was found to be significantly upregulated in HCC tissues and cell lines by qRT-PCR. Mechanically, circ_0008934 was a sponge of miR-1305 to facilitate the TMTC3 expression, and the TMTC3 expression in HCC tissues was negatively associated with the survival of HCC patients. Furthermore, rescued assays revealed that the circ_0008934 facilitated HCC proliferation, invasion and migration by regulating miR-1305/ TMTC3 signaling pathways. High level of circ_0008934 is closely associated with higher serum AFP (P < 0.001), larger tumor diameter (P = 0.012), microvascular invasion (P = 0.008) and poorer prognosis (P = 0.007) of HCC patients. Yes Functionally, knockdown of circ_0008934 inhibited HCC cell proliferation, invasion and migration in vitro and vivo. 35015267 hsa_circ_0001955 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction( circ_0001955/miR-655-3p/ACER3) qRT-PCR Circ_0001955 was highly expression in HCC tissues and cells.Mechanistically, circ_0001955 could competitively sponge miR-655-3p, which targeted ACER3. Besides that, miR-655-3p silencing abolished the anticancer action of circ_0001955 silencing on HCC cells. Moreover, miR-655-3p overexpression inhibited HCC cell oncogenic phenotypes mentioned above, which were attenuated by ACER3 up-regulation. Additionally, circ_0001955 knockdown also impeded HCC growth in a mouse model. Yes Functionally, circ_0001955 deletion suppressed HCC tumorigenesis in vitro by suppressing cell growth, metastasis and angiogenesis. 35034572 circRERE CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miR-1299 or ZC3H13 ) qRT-PCR The expression of circRERE was significantly upregulated in HCC cells, and its downregulation reduced HCC cell viability and invasion while increasing apoptosis. Further study showed that circRERE bound directly to miR- 1299. After downregulating the expression of circRERE, miR-1299 expression was significantly enhanced, while the expression of its downstream target gene GBX2 was suppressed, indicating that circRERE promoted the expression of GBX2 through miR-1299. Yes The expression of circRERE was significantly upregulated in HCC cells, and its downregulation reduced HCC cell viability and invasion while increasing apoptosis. 36222159 hsa_circ_0008092 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-502-5p/CCND1 Axis) qRT-PCR Circ_0008092 was highly expressed in HCC tissues and cells, which was associated with a shorter survival time in patients with HCC. Circ_0008092 directly targeted miR-502-5p and negatively modulated miR-502-5p expression. CCND1 Conclusion: Our data suggest that circ_0008092 promotes HCC progression by regulating the miR- 502-5p/CCND1 axis. Yes Circ_0008092 overexpression promoted proliferation, migration and invasion, and inhibited apoptosis of HCC cells; circ_0008092 knockdown worked oppositely. 35899951 hsa_circ_0061140 CircRNA Homo sapiens Ovarian Neoplasms cell lines Regulation[miR-370/FOXM1 pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay Our results showed that hsa_circ_0061140 was upregulated in ovarian cancer cell lines. Thus, hsa_circ_0061140 appeared to function as a competing endogenous RNA of miR-370 that promoted cell growth and metastasis in ovarian cancer through regulation of the miR-370/FOXM1 pathway mediating EMT. Yes Knockdown of hsa_circ_0061140 suppressed cell proliferation and migration, both in vivo and in vitro, by inhibiting FOXM1 expression through sponging miR-370. 30236833 circWHSC1 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Interaction[sponging miR-145 and miR-1182] RNA Pull-Down//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay We found that circWHSC1 was up-regulated in ovarian cancer tissues.Additionally, circWHSC1 could sponge miR-145 and miR-1182 and up-regulate the expression of downstream targets MUC1 and hTERT. Exosomal circWHSC1 can be transferred to peritoneal mesothelial cells and promotes peritoneal dissemination. We found that circWHSC1 was up-regulated in ovarian cancer tissues, and circWHSC1 expression was higher in moderate & poor differentiation ovarian cancer tissues than in well differentiation ovarian cancer tissues. Yes Overexpression of circWHSC1 increased cell proliferation, migration and invasion, and inhibited cell apoptosis. Silence of circWHSC1 exerted the opposite effects. 31666098 hsa_circ_0051240 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Regulation[miR-637/KLK4 axis] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Microarray//Colony Formation Assay//Transwell Assay In this study, we identified hsa_circ_0051240 was significantly increased in ovarian cancer (OC) tissues. In addition, the inhibitory effects by blockage of hsa_circ_0051240 could be attenuated by the miR-637 inhibitor. Furthermore, we also identified that hsa_circ_0051240 act as a sponge of miR-637, and miR-637 directly targeted KLK4 mRNA in OC cells. Altogether, hsa_circ_0051240 promotes OC cell proliferation, migration and invasion through inhibiting the miR-637/KLK4 axis. Therefore, these results demonstrated that the hsa_circ_0051240/miR-637/KLK4 axis might serve as a therapeutic target for OC treatment. Yes Our results indicated that silencing of hsa_circ_0051240 inhibited OC cell proliferation, migration and invasion in vitro, and also prevented OC tumour formation in vivo. 30945557 circKRT7 CircRNA Homo sapiens Ovarian Neoplasms Ovarian cancer tissues,cell lines regulation[circKRT7-miR-29a-3p-COL1A1 Axis ] Western Blot//Wound Healing Assay//Colony Formation Assay//qRT-PCR//FISH//Luciferase Report Assay//IHC//Invasion Assay Our previous research found that KRT7 was abnormally highly expressed in ovarian cancer and plays a role in the progression of ovarian cancer.We found that circKRT7 can promote the proliferation and metastasis of ovarian cancer cells by absorbing miR-29a-3p, which leads to the up-regulation of COL1A1. Yes In vitro, knock-down of circKRT7 can inhibit the migration and invasion of ovarian cancer cells. In vivo experiments, the reduction of circKRT7 expression can also slow tumor growth, and this inhibition was partly counteracted after miR-29a-3p repression. 32982288 circPUM1 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Interaction[Sponging miR-615-5p and miR-6753-5p] qRT-PCR//Luciferase Report Assay qRT-PCR analysis showed upregulation of circPUM1 in ovarian cancer tissues compared with normal ovaries. Bioinformatics analysis and dual-luciferase reporter assays revealed that circPUM1 upregulated the expression of nuclear factor kappa B (NF-κB) and MMP2 by sponging miR-615-5p and miR-6753-5p. Further studies showed that exosomal circPUM1 acted on peritoneal mesothelial cells and increased tumor metastasis. In conclusion, our study indicates that circPUM1 not only promotes ovarian cancer proliferation, migration and invasion, but also acts on the peritoneum and contributes to metastasis of cancer in the form of cancer-derived exosomes. Yes Gain- and loss-of-function experiments indicated that circPUM1 increased cell proliferation, migration, and invasion and inhibited cell apoptosis. Intraperitoneal injection of circPUM1-knockout tumor cells in nude mice resulted in a decrease in the metastatic ability of the tumor. 31751911 hsa-circ-001567 CircRNA Homo sapiens Ovarian Neoplasms OC tissues Expression[highly expressed] qRT-PCR The results showed that VPS13C-has-circ-001567 was expressed at significantly higher levels in OC tumor tissues compared with pericarcinous tissues, and this overexpression was associated with tumor node metastasis stage and lymph node metastasis. The results showed that VPS13C-has-circ-001567 was expressed at significantly higher levels in OC tumor tissues compared with pericarcinous tissues, and this overexpression was associated with tumor node metastasis stage and lymph node metastasis. Yes We found that knockdown of VPS13C-has-circ-001567 significantly promoted apoptosis and inhibited the proliferation of SKOV3 and OV-1063 cells in vitro.Knockdown of VPS13C-has-circ-001567 significantly reduced the tumorigenicity of OC cells. 30376358 circFAM53B CircRNA Homo sapiens Ovarian Neoplasms OC tissues,cell lines Regulation[miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways] qRT-PCR circ‑FAM53B was overexpressed in OC specimens and cells and correlated with clinical severity and poor prognosis of OC patients.Collectively, the present results indicated that circ‑FAM53B could be a competing endogenous RNA (ceRNA) to competitively sponge miR‑646 and miR‑647 to upregulate VAMP2 and MDM2 expression at the post‑transcriptional level, thus mediating the cellular behaviors of OC cells. circ‑FAM53B was overexpressed in OC specimens and cells and correlated with clinical severity and poor prognosis of OC patients. Yes Subsequently, the regulatory effects of circ‑FAM53B on the proliferative, apoptotic, migratory, and invasive potential of OC cells were determined by loss/gain‑of‑function experiments. 31638250 circEPSTI1 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Interaction[sponging miR-942] RIP//Luciferase Report Assay//qRT-PCR qRT-PCR verified that circEPSTI1 was overexpressed in ovarian cancer. In summary, circEPSTI1 regulated EPSTI1 expression and ovarian cancer progression by sponging miR-942. Yes Inhibition of circEPSTI1 suppressed ovarian cancer cell proliferation, invasion but promoted cell apoptosis. 30887698 circRhoC CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Interaction[VEGFA] qRT-PCR//Luciferase Report Assay//RIP//Western Blot Our results showed that circRhoC was significantly up-regulated in ovarian cancer tissues compared to normal ovarian tissues.In conclusion, the oncogenic effect of RhoC in ovarian cancer is at least in part due to circRhoC, which functions not only as a miR-302e sponge to positively regulate VEGFA protein expression, but may also directly bind and modulate VEGFA expression. Yes Overexpression of circRhoC in CAOV3 ovarian cancer cell increased cell viability, migration and invasion ability; destroying circRhoC in A2780 had the opposite effects and inhibited ovarian tumour cell A2780 dissemination in the peritoneum in vivo. 31639291 circCSPP1 CircRNA Homo sapiens Ovarian Neoplasms ovarian cance tissues Interaction[as a miR-1236-3p sponge ] qRT-PCR Here, using quantitative reverse transcription (qRT)-PCR, we showed that circ-CSPP1 is highly expressed in ovarian cancer (OC) tissues. Altogether, our findings suggest that by acting as a miR-1236-3p sponge, circ-CSPP1 impairs the inhibitory effect of miR-1236-3p on ZEB1, which subsequently promotes EMT and OC development. Yes Subsequent silencing of circ-CSPP1 in OVCAR3 and A2780 cell lines revealed decreased cell growth, migration and invasion, while overexpression of circ-CSPP1 caused opposite results We also found that miR-1236-3p is a target of circ-CSPP1. 30965236 circSFMBT2 CircRNA Homo sapiens Carcinoma, Hepatocellular tissues Interaction(miR-665/TIMP3 axis) qRT-PCR In this study, we identified that a novel circRNA, circSFMBT2, was markedly downregulated by HBx. The mechanism of circSFMBT2 was to as a sponge of miR-665, which is a negative regulator of tissue inhibitor of metalloproteinases 3 (TIMP3). However, HBx downregulated circSFMBT2 via the interaction with DExH-box helicase 9 (DHX9), which binds to flanking circRNA-forming introns. Low expression of circSFMBT2 was correlated with poor prognosis and vascular invasion. Yes Functionally, overexpression of circSFMBT2 significantly inhibited HCC metastasis both in vitro and in vivo. 36159591 hsa_circ_002178 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation(SRSF1) qRT-PCR GEO2R-based analysis displayed that hsa_circRNA_002178 was upregulated in HCC tissues.echanically, hsa_circRNA_002178 bound to SRSF1 3'-untranslated region (UTR) and stabilized its expression. SRSF1 weakening eliminated the effects of pcDNA-hsa_circRNA_002178 on cell malignant behavior. Yes Overexpression or knockdown of hsa_circRNA_002178 encouraged or impeded HCC cell proliferation, migration, invasion, and EMT program. Finally, the knockdown of hsa_circRNA_002178 was confirmed to prevent xenograft tumor growth. 36065311 hsa_circ_0000711 CircRNA Homo sapiens Carcinoma, Hepatocellular tumor tissues interaction[targeting has-miR-103a-3p] CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining Based on the circRNA expression profile and RT-qPCR results, the expression level of hsa_circ_0000711 was overtly reduced in HCC tissues. Overexpression of hsa_circ_0000711 promoted the proliferation and inhibited the apoptosis of hepatoma cells via targeting has-miR-103a-3p. Yes The results of CCK-8 and EdU staining assays revealed that the proliferation of hepatoma cells in hsa_circ_0000711 overexpression group was evidently enhanced. 32373952 circSP3 CircRNA Homo sapiens Carcinoma, Hepatocellular 50 HCC tissues and matched adjacent nontumorous liver tissues Interaction(miR-198) Western Blot//Migration Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Invasion Assay//Transwell Assay By analyzing relevant circRNA databases (circBase, TargetScan and CircInteractome), we found that the miR-198-binding circRNA hsa_circSP3 is upregulated in HCC. CircSP3 expression correlated negatively with miR-198 expression in HCC tissues. Dual luciferase reporter assays indicated that circSP3 bound to miR-198. Yes CircSP3 overexpression in HCC cells induced expression of cyclin-dependent kinase 4, a target gene of miR-198. Silencing circSP3 inhibited HCC cell proliferation and migration by downregulating cyclin-dependent kinase 4, whereas inhibiting miR-198 reversed those effects. In vivo experiments confirmed that circSP3 promoted xenograft tumor growth. 34314379 circSLC7A11 CircRNA Homo sapiens Carcinoma, Hepatocellular Human tumor samples and The human HCC cell lines HepG2, Hep3B, HCCLM3, Huh7, and MHCC97H, and the immortalized hepatocyte cell line WRL68 Interaction(miR-330-3p/CDK1 axis) CCK8//qRT-PCR//Western Blot CircSLC7A11 (hsa_circ_0070975) was conserved and dramatically overexpressed in HCC tissues and cells. Our in vitro and in vivo experiments showed that circSLC7A11 markedly accelerated HCC progression and metastasis through the circSLC7A11/miR-330-3p/CDK1 axis. HCC patients showing high circSLC7A11 expression had worse prognoses. Yes Our in vitro and in vivo experiments showed that circSLC7A11 markedly accelerated HCC progression and metastasis through the circSLC7A11/miR-330-3p/CDK1 axis. 34844614 hsa_circ_0005397 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-326/PDK2 axis) CCK8//qRT-PCR//Colony Formation Assay//Flow Cytometry Hsa_circ_0005397 and PDK2 were up-regulated, whereas miR-326 was down-regulated in HCC tissues and cells. miR-326 was a direct target of hsa_circ_0005397, and inhibition of miR-326 reversed the inhibitory effect of hsa_circ_0005397 silencing on HCC progression. Moreover, PDK2 was a direct target of miR-326 and PDK2 overexpression abated the anti-cancer roles of miR-326 in HCC. Additionally, hsa_circ_0005397 regulated PDK2 expression by sponging miR-326. Yes Hsa_circ_0005397 knockdown inhibited cell proliferation and metastasis, and promoted apoptosis. miR-326 was a direct target of hsa_circ_0005397, and inhibition of miR-326 reversed the inhibitory effect of hsa_circ_0005397 silencing on HCC progression. 33783904 circEPB41L2 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and HCC cell linesC Interaction(miR-590-5p) CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The clinicopathological analysis revealed that down-regulation of circEPB41L2 was negatively associated with tumor size, vascular invasion and alpha-fetoprotein, while positively correlated with HCC prognosis. Bioinformatic analysis and luciferase reporter assay revealed that circEPB41L2 interacts directly with miR-590-5p and the corresponding biological functions were also verified in miRNA rescue experiments. The clinicopathological analysis revealed that down-regulation of circEPB41L2 was negatively associated with tumor size, vascular invasion and alpha-fetoprotein, while positively correlated with HCC prognosis. Yes The biological function experiments showed that overexpression of circEPB41L2 could obviously inhibit the proliferation and metastasis of HCC cells in vitro, while knockdown of circEPB41L2 induced opposite results. Moreover, we also found that circEPB41L2 inhibited HCC migration and invasion though EMT signaling pathway. Similarly, overexpression of circEPB41L2 can also significantly inhibit the proliferation of HCC cells in vivo. 33833580 circGFRA1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction( miR-498/NAP1L3 axis) qRT-PCR//IHC//Transwell Assay CircGFRA1 was greatly increased in HCC tissues and cells, and the over-expression of circGFRA1 was intimately related with the advanced clinical stage and poor survival of HCC patients. The expression of circGFRA1 was negatively correlated with the expression of miR-498, but a positive correlation was found between circGFRA1 and NAP1L3 expression in HCC tissues. CircGFRA1 was greatly increased in HCC tissues and cells, and the over-expression of circGFRA1 was intimately related with the advanced clinical stage and poor survival of HCC patients. Yes Silencing circGFRA1 inhibited the growth and invasion of hepatocellular carcinoma. Moreover, miR-498 over-expression or NAP1L3 inhibition could abrogate the oncogene role of circGFRA1 in HCC in vivo.  33431945 hsa_circ_0001806 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-125b/HK2) qRT-PCR//Luciferase Report Assay//Western Blot sa_circ_0001806 was up-regulated in HCC tissues and cells and positively associated with the advanced TNM stage, metastasis and poor overall survival. Furthermore, hsa_circ_0001806 acted as a sponge of miR-125b to up-regulate hexokinase II (HK2) expression. In addition, the inhibition of miR-125b and HK2 overexpression partly reversed the inhibitory effect of hsa_circ_0001806 silencing on HCC cell proliferation, migration and glycolysis. hsa_circ_0001806 was up-regulated in HCC tissues and cells and positively associated with the advanced TNM stage, metastasis and poor overall survival. Yes The overexpression of hsa_circ_0001806 promoted HCC cell proliferation, migration and glycolysis and inhibited cell apoptosis, while the silence of hsa_circ_0001806 showed an opposite effect. 34664737 hsa_circ_0001806 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-193a-5p/MMP16 pathway) CCK8//qRT-PCR//RIP Circ_0001806 was up-modulated in HCC tissues and cell lines. Circ_0001806 could up-regulate MMP16 expression through repressing miR-193a-5p, thereby facilitating the malignant biological behaviors of HCC. Circ_0001806 promoted HCC progression by regulating miR-193a-5p/MMP16 axis. Yes Knockdown of circ_0001806 impeded the multiplication, migration, and invasion of HCC cells. 34730679 circBACH1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-656-3p/SERBP1) Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay CircBAC- H1 and SERBP1 were upregulated in HCC tissues and cells.SERBP1 overexpression partially neutralized the repressive effect of circBACH1 silencing on malignant behaviors of HCC cells.CircBACH1 sponged miR-656-3p to elevate SERBP1 expression, thereby accelerating the progression of HCC. Yes Both circBACH1 and SERBP1 knockdown constrained proliferation, migration, invasion, and EMT(epithel-ial-mesenchymal transition), and facilitated apoptosis of HCC cells in vitro.Knockdo-wn of circBACH1 reduced HCC growth in vivo. 33831787 circZFR CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell Interaction(miR-375/HMGA2 Axis) qRT-PCR//Luciferase Report Assay//RIP CircZFR and HMGA2 were upregulated while miR-375 was downregulated in HCC tissues and cells. MiR-375 was a direct target of circZFR and its knockdown reversed the inhibitory effect of circZFR silence on the progression of HCC cells. Moreover, HMGA2 was a downstream target of miR-375, and miR-375 suppressed proliferation and glycolysis and induced apoptosis by targeting HMGA2 in HCC cells. Besides, circZFR acted as a molecular sponge of miR-375 to regulate HMGA2 expression. Yes CircZFR silence inhibited HCC progression by inhibiting cell proliferation, glycolysis and tumor growth and promoting apoptosis. 33433801 circUBAP2 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-4756/IFIT1/3 axis) qRT-PCR//MTT//IHC//IF CXCL11 stimulation upregulated circUBAP2 expression, which was significantly higher in HCC tissues than para-carcinoma tissues. Further downstream, the IFIT1 and IFIT3 levels were significantly upregulated in HCC cells upon CXCL11 stimulation, but downregulated upon circUBAP2 silencing. IFIT1 or IFIT3 silencing reduced the expression of IL-17 and IL-1β, and attenuated the migration capability of HCC cells. Herein, circUBAP2 counteracted miR-4756-mediated inhibition on IFIT1/3 via sponging miR-4756. miR-4756 inhibition reversed the effects induced by circUBAP2 silencing on the IL-17 and IL-1β levels and HCC cell migration. In orthotopic models, miR-4756 inhibition also reversed the effects on metastatic progression induced by silencing circUBAP2. Yes Silencing circUBAP2 reversed the effects of CXCL11 on the expression of IL-1β/IL-17 and HCC cell migration. 33707417 circUBE2J2 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(microRNA-370-5P/KLF7) Western Blot//qRT-PCR//RIP//FISH//IHC CircUBE2J2 expression in HCC cells was selectively regulated via luciferase reporter assays; circUBE2J2 and KLF7 were observed to directly bind to miR-370-5P. Furthermore, knockdown of circUBE2J2 in HCC could downregulate KLF7, the target of miR-370-5P, thus promoting the proliferation and migration of HCC cells. Then the related experiment suggested that circUBE2J2 could regulate the expression of KLF7 by sponging miR-370-5p. Yes Furthermore, knockdown of circUBE2J2 in HCC could downregulate KLF7, the target of miR-370-5P, thus promoting the proliferation and migration of HCC cells. 34686662 hsa_circ_0058493 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC patients Interaction(METTL3-hsa_circ_0058493-YTHDC1 ) qRT-PCR//Invasion Assay In this research, a novel circRNA, hsa_circ_0058493, was proven to be upregulated in HCC, which was correlated with the prognosis of HCC patients. Mechanistic experiments revealed that hsa_circ_0058493 contained m6A methylation sites and that methyltransferase-like 3 (METTL3) mediated the degree of methylation modification of hsa_circ_0058493. Taken together, this study explored the oncogenic role of m6A-modified hsa_circ_0058493 and found to accelerate HCC progression via the METTL3-hsa_circ_0058493-YTHDC1 axis. Yes Experimentally, hsa_circ_0058493 knockdown suppressed the growth and metastasis of HCC cells in vivo and in vitro. On the contrary, the overexpression of hsa_circ_0058493 in HCC cells had the opposite effect in vitro. 34888309 hsa_circ_0110102 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines and tissues Interaction( miR-580-5p/PPARα/CCL2 pathway) qRT-PCR//ELISA//Western Blot//ChIP The expression level of hsa_circ_0110102 was significantly downregulated in HCC cell lines and tissues, which was associated with poor prognosis. These results concluded that hsa_circ_0110102 acted as a sponge for miR-580-5p and inhibited CCL2 secretion into tumor microenvironment by decrease the expression of PPARα in HCC cells, then inhibited the pro-inflammatory cytokine release from macrophages by regulating the COX-2/PGE2 pathway. Yes Knockdown hsa_circ_0110102 significantly promoted cell proliferation, migration, and invasion. 33891564 hsa_circ_0007456 CircRNA Homo sapiens Carcinoma, Hepatocellular tumor tissue Interaction(miR-6852-3p/ICAM-1 axis) qRT-PCR//Luciferase Report Assay//Western Blot In our previous study, we performed a microarray analysis of circRNAs between the tumor tissues and the adjacent normal tissues of hepatocellular carcinoma (HCC) patients, and found that the circRNA hsa_circ_0007456 is significantly downregulated in the tumor tissues and correlated with the prognosis of HCC. Through a series of screening and validation, we found that hsa_circ_0007456 mainly functioned through sponging miR-6852-3p and regulating the expression of intercellular adhesion molecule-1 (ICAM-1) in HCC. The miR-6852-3p/ICAM-1 axis is essential for the NK cytotoxicity toward HCC mediated by hsa_circ_0007456. Yes We further investigated the relationship between the expression levels of hsa_circ_0007456 in HCC and the susceptibility of NK cells, and found that the expression levels of hsa_circ_0007456 in HCC cell lines significantly influenced their susceptibility to NK cells. 33462208 hsa_circ_0013290 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines Expression(highly expressed) qRT-PCR//Transwell Assay hsa_circ_0013290 is significantly upregulated in HCC cell lines and mainly located in cytoplasm of HCC cells. Yes Hsa_circ_0013290 overexpression promotes cell invasion and migration and inhibits cell apoptosis. In contrast, hsa_circ_0013290 knockdown impedes cell invasion and migration and accelerates cell apoptosis. However, hsa_circ_0013290 did not affect cell proliferation. 34798782 hsa_circ_0000098 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction( miR-1204/ALX4 ) qRT-PCR//Luciferase Report Assay//RIP//Transwell Assay Circ_0000098 expression level was markedly declined in HCC tissues and cells, and its underexpression was associated with larger tumor size of HCC patients. Additionally, circ_0000098 was mainly distributed in the cytoplasm of HCC cells, and up-regulated ALX4 expression through competitively decoying miR-1204. Yes Knocking down circ_0000098 observably promoted the multiplication, migration, invasion, and epithelial-mesenchymal transition (EMT) of Huh7 and SMMC-7721 cells. 34900665 hsa_circ_0001955 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-646/FZD4 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//IHC//Transwell Assay Circ_0001955 was a highly expressed circRNA in HCC tissues and cells. Meanwhile, miR-646 could be sponged by circ_0001955, and its inhibitor could reverse the negative regulation of circ_0001955 knockdown on HCC progression. Further, FZD4 was a target of miR-646, and its overexpression could invert the inhibition effect of miR-646 mimic on HCC progression. Yes Circ_0001955 knockdown inhibited the proliferation, metastasis, angiogenesis, and enhanced the apoptosis of HCC cells. 34021822 hsa_circ_0003006 CircRNA Homo sapiens Carcinoma, Hepatocellular 115 tumors and corresponding paracancerous tissue samples Interaction(miR-542-3p) qRT-PCR//Luciferase Report Assay//Western Blot The target miR‑542‑3p and target gene HIF-1A were predicted by bioinformatics analysis, then verified through biotinylated RNA pull-down and dual-luciferase reporter assays. The mechanism, circ-0003006, probably acted as a sponge of miR‑542‑3p and regulated HIF-1A levels in hepatocellular carcinoma cells. Yes Cell account kit 8 (CCK-8) and transwell assay were revealed that circ-0003006 knockdown inhibited the proliferation and metastasis in HCC cells.The subcutaneous tumor formation experiment indicated that circ-0003006 knockdown inhibited the HCC cell growth in vivo. 34675680 circEPS15 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression(lower expressed) qRT-PCR The validation of dysregulated circRNAs by qRT-PCR revealed that circEPS15 expression was downregulated in HCC tissues, and the survival curves showed that low circEPS15 levels were associated with poor overall survival in HCC patients. T The validation of dysregulated circRNAs by qRT-PCR revealed that circEPS15 expression was downregulated in HCC tissues, and the survival curves showed that low circEPS15 levels were associated with poor overall survival in HCC patients. Yes Then, the overexpression of circEPS15 suppressed tumor cell invasion and migration by inhibiting the TJP1/CDH2/VIM signaling pathway and retarded cell cycle progression, which was confirmed by the Transwell culture system, wound healing assays, flow cytometry and western blot assays. 35211158 circANTXR1 CircRNA Homo sapiens Carcinoma, Hepatocellular peripheral blood, tumor tissues and paracancerous normal tissues Expression [highly expressed] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay CircANTXR1 was a stable and highly expressed circRNA in HCC. MiR-532-5p could be sponged by circANTXR1, and its inhibitor could reverse the inhibition of circANTXR1 silencing on HCC cells progression. Yes Silenced circANTXR1 inhibited the proliferation, migration and invasion of HCC cells in vitro, and suppressed HCC tumor growth in vivo. 34786378 hsa_circ_0001178 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and HCC cells regulation[miR-382/VEGFA axis] qRT-PCR In our current work, we tested circ_0001178 expression in HCC tissues and HCC cells and found it was greatly elevated. To conclude, this research revealed that circ_0001178 induced HCC progression via modulating miR-382 and VEGFA axis. Yes Meanwhile, it was shown that HCC cell migration and invasion capacity were markedly inhibited by loss of circ_0001178. Knockdown of circ_0001178 restrained HCC tumor growth in vivo. 32240747 circMAN2B2 CircRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular tissues regulation[miRNA-217/MAPK1 axis] CCK8//qRT-PCR In this study, we investigated differences in the expression of circRNA MAN2B2 (circMAN2B2) in hepatocellular tissues and paired normal tissues. In summary, our study indicated that circMAN2B2 acted as an onco-miRNA in HCC by sponging miRNA-217 to promote MAPK1 expression. Yes We found that knockdown of circMAN2B2 expression in the HCC cell lines Hep-G2 and Huh-7 significantly inhibited cell proliferation by sponging (miRNA) miR-217 and inhibiting its function. 32231737 circABCB10 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-340-5p/miR-452-5p] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot The results revealed that the expression of circ-ABCB10 was downregulated in both HCC tissues and cell lines and was positively correlated with histological grade and tumor size. The results revealed that the expression of circ-ABCB10 was downregulated in both HCC tissues and cell lines and was positively correlated with histological grade and tumor size. Yes The overexpression of circ-ABCB10 exerted inhibitory effects on HCC cell proliferation, invasion, and migration. 32196586 hsa_circ_0009910 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-335-5p/ROCK1 axis] Western Blot//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Circ_0009910 was upregulated in HCC tissues and cell lines.Circ_0009910-silenced suppressed the growth and metastasis of HCC cells through upregulating the inhibitory effect of miR-335-5p on ROCK1. Yes Knockdown of circ_0009910 significantly inhibited the proliferation, migration, and invasion of HepG2 cells and suppressed tumor growth and metastasis in vivo. 32141540 hsa_circ_0091581 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC and adjacent normal tissues regulation[hsa_circ_0091581/miR-526b/c-Myc/hsa_circ_0091581 ] qRT-PCR Upregulation of hsa_circ_0091581 was identified by RNA-sequencing and validated by quantitative real-time polymerase chain reaction (qRT-PCR).These results revealed that hsa_circ_0091581/miR-526b/c-Myc/hsa_circ_0091581 positive feedback loop plays a vital role in HCC progression and hsa_circ_0091581 may be a potential prognostic biomarker and therapeutic target for HCC. Hsa_circ_0091581 expression was correlated with tumor size, disease-free survial and overall survival of HCC patients. Yes Functionally, hsa_circ_0091581 could promote the proliferation of HCC cells in vitro. 32116112 hsa_circ_0011946 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[inducing the EMT process] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay In this research, the expression level of hsa_circ_0011946 was significantly increased in HCC tissues compared to that in adjacent samples.The hsa_circ_0011946 could enhance cell migration and invasion of HCC by inducing the EMT process. The hsa_circ_0011946 expression was associated with lymphatic metastasis in HCC patients. Yes Knockdown of hsa_circ_0011946 led to the inhibition of cell migration and invasion in HCC. 32096173 hsa_circ_0056836 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines and tissues regulation[miR-766-3p/FOSL2 axis] qRT-PCR//Luciferase Report Assay//FISH The present study showed that hsa_circ_0056836 revealed high expressions in HCC cell lines and tissues compared with corresponding controls. In summary, the hsa_circ_0056836 / miR-766-3p / FOSL2 axis may serve as a promising strategy for HCC treatment. Yes Silencing of Hsa_circ_0056836 decreased cell migration, proliferation and invasion. Silencing of hsa_circ_0056836 inhibited the development of HCC in xenograft nude mice. 32048611 circPVT1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[circPVT1/miR-3666/SIRT7] qRT-PCR Herein, we found that circPVT1 expression was significantly upregulated in HCC tissues and cell lines. Our study highlights the involvement of circPVT1/miR-3666/SIRT7 in regulating HCC cell growth. Yes Knockdown of circPVT1 significantly reduced the growth and colony formation, and increased cell apoptosis, of HCC cells. 32017171 circBACH1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[circBACH1/HuR/p27 axis] qRT-PCR//RNA Pull-Down//RIP//FISH Here, we found that circBACH1 was significantly upregulated in HCC tissues and that high circBACH1 levels were closely associated with poor prognosis.In sum, circBACH1 plays a significant role as an oncogene through the circBACH1/HuR/p27 axis in HCC development. Yes In addition, circBACH1 could promote HCC growth by accelerating cell cycle progression in vitro and in vivo. 32003018 circTCF4.85 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-486-5p-targeted inhibition of ABCF2] qRT-PCR//FISH Circ-TCF4.85 was detected to be highly expressed in HCC tissues. Taken together, our results reveal that silencing of circ-TCF4.85 suppresses HCC progression via miR-486-5p-targeted inhibition of ABCF2. Yes Next, we found that silencing of circ-TCF4.85 repressed HCC cell proliferation, invasion, and migration, while enhancing apoptosis. 31758671 circIPO11 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues and liver CSCs Expression [highly expressed] Northern Blot//ChIP CircIPO11 is highly expressed in HCC tumor tissues and liver CSCs.CircIPO11 is required for the self-renewal maintenance of liver CSCs to initiate HCC development. Mechanistically, circIPO11 recruits TOP1 to GLI1 promoter to trigger its transcription, leading to the activation of Hedgehog signaling. Additionally, circIPO11 knockout in mice suppresses the progression of chemically induced liver cancer development. Yes Additionally, circIPO11 knockout in mice suppresses the progression of chemically induced liver cancer development. 34649567 circCAMSAP1 CircRNA Homo sapiens Carcinoma, Hepatocellular GEO(three pairs of HCC tissues and its adjacent normal tissues) Interaction(miR-1294/GRAMD1A ) In Vivo Experiment//RNA Pull-Down//Bioinformatics Analysis//Wound Healing Assay//Invasion Assay//RIP//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay The expression of circCAMSAP1 was up-regulated in HCC tissues compared with its adjacent normal tissues. Yes Up-regulation of circCAMSAP1 promoted HCC biological functions both in vitro and in vivo. The promotive effects of circCAMSAP1 on HCC progression function through miR-1294/GRAMD1A pathway. 33484498 hsa-circ_103809 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines Interaction(miR-1270) RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Transwell Assay CircRNA-103809 was highly expressed in HCC cell lines. Yes After interfering circRNA-103809, the proliferation, migration, invasion and epithelial-to-mesenchymal transition process were all hindered in HCC cells. Significantly, circRNA-103809 competed with PLAG1 like zinc finger 2 (PLAGL2) for binding with microRNA-1270 (miR-1270), which formulated a competing endogenous RNA network in HCC. 32683589 hsa_circ_0021093 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-432/Annexin A2) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Circ_0021093 was highly expressed in HCC tissues and cells, and its level was associated with poor prognosis of HCC patients. Circ_0021093 was highly expressed in HCC tissues and cells, and its level was associated with poor prognosis of HCC patients. Yes Functional experiments showed that knockdown of circ_0021093 repressed proliferation, migration and invasion in vitro and tumor growth in vivo by regulating miR-432, while upregulation of circ_0021093 reversed these results. 33675609 hsa_circ_0006602 CircRNA Homo sapiens Carcinoma, Hepatocellular plasma exosomes of primary hepatocellular carcinoma patient and healthy volunteer Expression [highly expressed] CCK8//qRT-PCR//Invasion Assay//Western Blot Among them, it is further confirmed that exo_circ_0006602 is up-regulated in the large sample cohort. Yes Cell function experiments show that exo_circ_0006602 can significantly improve the proliferation and invasion ability of liver cancer cell lines and also promoted the expression of tumor proliferation-related protein Snail.  34306340 hsa_circ_NOTCH3 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC specimens and cells Interaction(miR-875-5p) Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay It was confirmed circ_NOTCH3 was highly expressed in HCC specimens and cells. In terms of mechanism, circ_NOTCH3 directly binds to miR-875-5p, regulating its activity by targeting the 3'-UTR of ZNF146. Yes The proliferation, migration, invasion, and oxaliplatin-resistance potential of HCC could be restrained by silencing circ_NOTCH3 or by ectopic expression of miR-875-5p in vitro. 34790400 hsa_circ_0008274 CircRNA Homo sapiens Carcinoma, Hepatocellular The tissues adjacent to cancer and cancer tissues of 55 patients with HCC Interaction(microRNA -140-3p) CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Herein we reported that circ_0008274 was highly expressed in HCC, and its high expression enhanced the proliferation, migration, and invasion of HCC cells, while depleting circ_0008274 inhibited the malignant biological behaviors of HCC cells. Mechanistically, circ_0008274 upregulates GRN expressions via adsorbing miR-140-3p to expedite the progression of HCC. Yes its high expression enhanced the proliferation, migration, and invasion of HCC cells, while depleting circ_0008274 inhibited the malignant biological behaviors of HCC cells. 34002672 circDOCK1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miR-654-5p/SMAD2 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay As a result, the expression of circRNA DOCK1 and SMAD2 was increased, and miR‑654‑5p was decreased in HCC cells. circRNA DOCK1 directly targeted to miR‑654‑5p and miR‑654‑5p directly targeted to SMAD2. Yes Interference with circRNA DOCK1 inhibited the proliferation, invasion and migration of HCC cells by upregulating miR‑654‑5p expression. 34184075 circSCARB1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC and paired adjacent (within 3 cm around tumors) non-tumor tissues Interaction(miR-497) CCK8//qRT-PCR//Transwell Assay We found that circRNA SCARB1 was upregulated in HCC. In addition, mature miR-497 and miR-497 were downregulated in HCC. Yes Analysis of cellular behaviors showed that overexpression of circRNA SCARB1 increased the proliferation and migration of HCC cells, while overexpression of miR-497 decreased cell proliferation and migration. 34305409 circFAM13B CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue Interaction(miR-212/E2F5/ P53 pathway) CCK8//qRT-PCR//RIP//FISH We found that circFAM13B was the most significantly differentially expressed circRNA in HCC tissue. Further studies revealed that circFAM13B, a sponge of miR-212, is involved in the regulation of E2F5 gene expression by competitively binding to miR-212, inhibits the activation of the P53 signalling pathway, and promotes the proliferation of HCC cells. Yes Subsequently, in vitro and in vivo studies also demonstrated that circFAM13B promoted the proliferation of HCC. 34348712 hsa_circ_0091579 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-624/H3F3B axis) Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis Circ_0091579 was upregulated in HCC tissues and cells. MiR-624 was downregulated, while H3F3B was upregulated in HCC tissues and cells. Circ_0091579 acted as a miR-624 sponge and regulated H3F3B expression by adsorbing miR-624. Yes Circ_0091579 inhibition decreased xenograft tumor growth in vivo and repressed Warburg effect, migration, invasion, and induced apoptosis of HCC cells in vitro. 33934291 circGLIS2 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(EIF4A3) RNA Pull-Down//CCK8//qRT-PCR//RIP//IHC//Transwell Assay Circ_GLIS2 and linear GLIS2 mRNA were reduced in human HCC tissues and cells. GLIS2 promoter region was hypermethylated in HCC cells. EIF4A3 was directly bound with GLIS2 mRNA and promoted circ_GLIS2/GLIS2 expression. Their low levels correlated with a poor survival rate of HCC patients. Yes Overexpression of circ_GLIS2 and GLIS2 suppressed HCC cell proliferation, migration, and invasion but promoted cell apoptosis. Moreover, overexpression of circ_GLIS2 restrained HCC tumour growth and metastasis in vivo. 34743403 circMRPS35 CircRNA Homo sapiens Carcinoma, Hepatocellular 35 pairs of HCC from patients Interaction(miR-148a/STX3/PTEN) qRT-PCR//IHC In this study, we identified a functional RNA, hsa_circ_0000384 (circMRPS35), from public tumor databases using a set of computational analyses, and we further identified that circMRPS35 was highly expressed in 35 pairs of HCC from patients.Mechanically, circMRPS35 sponged microRNA-148a-3p (miR-148a), regulating the expression of Syntaxin 3 (STX3), which modulated the ubiquitination and degradation of phosphatase and tensin homolog (PTEN). Unexpectedly, we detected a peptide encoded by circMRPS35 (circMRPS35-168aa), which was significantly induced by chemotherapeutic drugs and promoted cisplatin resistance in HCC. Yes Moreover, knockdown of the expression of circMRPS35 in Huh-7 and HCC-LM3 cells suppressed their proliferation, migration, invasion, clone formation, and cell cycle in vitro, and it suppressed tumor growth in vivo as well. 34450251 hsa_circ_0091579 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-1225-5p/PLCB1 Axis) qRT-PCR Expression of circ_0091579 and PLCB1 was increased, while miR-1225-5p expression was decreased in HCC tissues and cells. Circ_0091579 sponged miR-1225-5p to upregulate PLCB1 expression in HCC cells. Silencing of miR-1225-5p contributed to HCC progression, which was mitigated by PLCB1 depletion. Yes Circ_0091579 or PLCB1 depletion had inhibitory effects on HCC cell proliferation and metastasis. Circ_0091579 deficiency could suppress HCC tumor growth in vivo. 33559088 hsa_circ_0074854 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and HCC cell lines Expression(highly expressed) qRT-PCR Hsa_circ_0074854 expression was upregulated in HCC tissues and HCC cell lines. Mechanistically, hsa_circ_0074854 knockdown inhibited the migration and invasion of HCC cells via interacting with human antigen R (HuR) to reduce its stability. Yes Additionally, hsa_circ_0074854 knockdown was found to inhibit HCC growth in vitro and in vivo. 33880025 hsa_circ_0003410 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-139-3p/CCL5 axis) qRT-PCR Using high-throughput RNA sequencing, we demonstrated that hsa_circ_0003410 was clearly upregulated in HCC. Mechanistically, we identified CCL5 as the target gene of hsa_circ_0003410. RNA-FISH showed the co-expression of hsa_circ_0003410 and CCL5. Western blot and ELISA also verified that hsa_circ_0003410 could upregulate the expression of CCL5 protein. Yes 5-Ethynyl-2'-deoxyuridine and transwell assays showed that hsa_circ_0003410 facilitated the proliferation and migration of HCC cells in vitro. 34890089 hsa_circ_0013958 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC patients Interaction(miR-532-3p/WEE1 Axis) qRT-PCR It revealed that circ0013958 was significantly up-regulated in HCC, which was positively correlated with poor prognosis of HCC patients. Circ0013958 acted as a miR-532-3p sponge to regulate WEE1 expression, thus promoting the progression of HCC. It revealed that circ0013958 was significantly up-regulated in HCC, which was positively correlated with poor prognosis of HCC patients. Yes Circ0013958 promoted HCC cell proliferation and invasion, inhibited cell apoptosis in vitro, and promoted tumorigenesis in vivo. 33937016 circSEC24A CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miR-455-3p/PPM1F) qRT-PCR circSEC24A acted as a molecular sponge to sequester miR-455-3p, resulting in elevating the expression of PPM1F. miR-455-3p inhibitor reversed the suppressive impact of circSEC24A silencing on malignant behaviors of HCC cells. PPM1F overexpression offsets the inhibitory effect of miR-455-3p mimic on malignant behaviors of HCC cells. circSEC24A sponged miR-455-3p to elevate the PPM1F expression, resulting in accelerating malignant behaviors of HCC cells. The study provided a potential therapeutic target for patients with HCC. Yes circSEC24A silencing decreased xenograft tumor growth in vivo and repressed proliferation, metastasis, invasion, epithelial-to-mesenchymal transition (EMT), induced cell cycle arrest, and apoptosis of HCC cells in vitro. The relationship between circSEC24A or PPM1F and miR-455-3p was verified by a dual-luciferase reporter and/or RNA immunoprecipitation (RIP) assays. 34459207 circNFIX CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miR-3064-5p/HMGA2 axis) qRT-PCR Our results showed that circNFIX was remarkably up-regulated in HCC and was associated with a poor survival. Knockdown of circNFIX repressed proliferation, invasion and glutaminolysis of HCC cells. Moreover, circNFIX directly sponged miR-3064-5p to release HMGA2 expression, and thus conferred the malignant development of HCC. circNFIX directly sponged miR-3064-5p to release HMGA2 expression, and thus conferred the malignant development of HCC. Yes Knockdown of circNFIX repressed proliferation, invasion and glutaminolysis of HCC cells. 34539988 hsa_circ_0072088 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue and cell lines Regulation(miR-375/JAK2/STAT3 signaling pathway) qRT-PCR Circ_0072088 and JAK2 mRNA expressions were highly expressed in HCC tissues and cell lines while miR-375 expression was remarkably downregulated. Circ_0072088 was resistant to RNase R treatment and mainly located in the cytoplasm of HCC cells. The transfection of circ_0072088 overexpression plasmid or miR-375 inhibitors promoted the proliferation, migration, and invasion, and inhibited the apoptosis of HCC cells, whereas transfection of circ_0072088 siRNA or miR-375 mimics exerted opposite effects. Besides, miR-375 was confirmed as a target of circ_0072088 and miR-375 could further downregulate the expression of JAK2. MiR-375 mimics could reverse the upregulation of JAK2 and p-STAT3 protein induced by circ_0072088 overexpression. Circ_0072088 can enhance the proliferation, migration, and invasion, and impede apoptosis of HCC cells. Mechanistically, circ_0072088 activates JAK2/STAT3 signaling pathway by serving as a molecular sponge of miR-375. Yes MiR-375 mimics could reverse the upregulation of JAK2 and p-STAT3 protein induced by circ_0072088 overexpression. 34148288 hsa_circ_0004018 CircRNA Homo sapiens Carcinoma, Hepatocellular THLE-3 & HUVECs Interaction( FUS/TIMP2 ) qRT-PCR circ_0004018 was definitely down-regulated in HCC.estrogen receptor 1 (ESR1) mediated circ_0004018 regulated TIMP2 by recruiting FUS. A series of rescue assays verified that circ_0004018 participated in angiogenesis in HCC via modulating TIMP2. In summary, this paper disclosed that ESR1 activated circ_0004018 inhibited angiogenesis in HCC via binding to FUS and stabilizing TIMP2 expression. Yes we found that overexpression of circ_0004018 significantly inhibited angiogenesis in HCC. 34487732 circLRIG3 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-449a/LRIG3 axis) qRT-PCR circ_LRIG3 expression was upregulated in HCC tissues and cells. Knockdown of circ_LRIG3 suppressed proliferation, migration and invasion and facilitated cell apoptosis in HCC cells in vitro and blocked tumor growth of HCC in vivo. RNF38 overexpression reversed the effects of circ_LRIG3 knockdown on the malignant behaviors of HCC cells. Moreover, circ_LRIG3 could sponge miR-449a to positively modulate RNF38 expression in HCC cells. circ_LRIG3 knockdown inhibited the progression of HCC cells by sponging miR-449a. In addition, circ_LRIG3 silencing might inhibit the Smad2/3 pathway. Yes Knockdown of circ_LRIG3 suppressed proliferation, migration and invasion and facilitated cell apoptosis in HCC cells in vitro and blocked tumor growth of HCC in vivo. RNF38 overexpression reversed the effects of circ_LRIG3 knockdown on the malignant behaviors of HCC cells. 33880997 hsa_circ_0003288 CircRNA Homo sapiens Carcinoma, Hepatocellular L02 and HCC cells Interaction(hsa_circ_0003288/miR-145/PD-L1 axis) qRT-PCR miR-145 directly targeted the PD-L1 3'-untranslated region (UTR) region, and hsa_circ_0003288 acted as a miR-145 sponge to regulate PD-L1 expression. Overexpression of hsa_circ_0003288 increased PD-L1 levels and promoted EMT, migration, and invasiveness of L02 cells. These observations were reversed after knockdown of hsa_circ_0003288 in HepG2 and Huh7 cells. Overexpression of PD-L1 rescued EMT, migration, and invasiveness of HepG2 and Huh7 cells after knockdown of hsa_circ_0003288. Furthermore, hsa_circ_0003288 knockdown reduced EMT in in vivo studies. Hsa_circ_0003288/PD-L1 axis was found to mediate the metastatic phenotypes via the PI3K/Akt pathway in HCC. Additionally, expression levels of hsa_circ_0003288 were increased and positively correlated with PD-L1 expression in HCC tissues. Yes Overexpression of hsa_circ_0003288 increased PD-L1 levels and promoted EMT, migration, and invasiveness of L02 cells. These observations were reversed after knockdown of hsa_circ_0003288 in HepG2 and Huh7 cells. Overexpression of PD-L1 rescued EMT, migration, and invasiveness of HepG2 and Huh7 cells after knockdown of hsa_circ_0003288. Furthermore, hsa_circ_0003288 knockdown reduced EMT in in vivo studies. 33858418 circETFA CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues, plasma, and cells Interaction(miR-612) qRT-PCR CircETFA was overexpressed in HCC tissues, plasma, and cells. Clinicopathological data revealed that abnormally high circETFA expression was associated with a poor prognosis. In function, circETFA promotes the malignant phenotype of HCC cells in vivo and in vitro, inhibits cycle arrest, and decreases the proportion of apoptotic cells. In mechanism, it can upregulate C-C motif chemokine ligand 5 (CCL5) in HCC cells, thereby regulating the phosphoinositide 3-kinase (PI3K)/Akt pathway and other key downstream effectors (e.g., FoxO6). Furthermore, circETFA prolonged the half-life of CCL5 mRNA by recruiting the eukaryotic initiation factor 4A3 (EIF4A3) and acted as a sponge of hsa-miR-612 to suppress the silencing effect of hsa-miR-612 on CCL5. In conclusion, CircETFA can increase the expression of CCL5 to promote the progression of HCC by sponging hsa-mir-612 and recruiting EIF4A3, and is promising as a novel biomarker and therapeutic target. Clinicopathological data revealed that abnormally high circETFA expression was associated with a poor prognosis. Yes In function, circETFA promotes the malignant phenotype of HCC cells in vivo and in vitro, inhibits cycle arrest, and decreases the proportion of apoptotic cells. 34716323 circCCND1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-497-5p/HMGA2 Axis) qRT-PCR Circ-CCND1 and HMGA2 expressions in HCC were significantly up-regulated and miR-497-5p expression was markedly decreased. Mechanistically, miR-497-5p was a direct target of circ-CCND1 and miR-497-5p specifically modulated HMGA2 expression. Furthermore, miR-497-5p inhibitors and or HMGA2 overexpression partially counteracted the suppressing effect induced by si-circ-CCND1 on the malignant phenotype of HCC cells. Circ-CCND1 plays a cancer-promoting role in HCC by modulating the miR-497-5p/HMGA2 axis. High circ-CCND1 expression was associated with relatively large tumor size and lymph node metastasis in HCC patients. I Yes Functionally, knockdown of circ-CCND1 remarkably suppressed HCC cell proliferation, migration, and invasion. 34564768 hsa_circ_0016788 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-506-3p/PARP14) qRT-PCR The levels of hsa_circ_0016788 and PARP14 were upregulated, and the miR-506-3p level was decreased in HCC tissues in contrast to that in normal tissues. Moreover, miR-506-3p was confirmed to repress the progression of HCC cells by suppressing PARP14. In mechanism, hsa_circ_0016788 acted as a miR-506-3p sponge to regulate the level of PARP14. In addition, hsa_circ_0016788 knockdown also inhibited tumor growth in vivo. Yes For functional analysis, hsa_circ_0016788 deficiency inhibited cell glycolysis metabolism, cell vitality, cell proliferation, colony formation, and invasion in HCC cells whereas promoted cell apoptosis. 34340259 hsa_circ_0062682 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC patients Interaction(YBX1) qRT-PCR By implementing available transcriptomic analyses of HCC patients, we identified an upregulated circRNA hsa_circ_0062682. Pathway enrichment analysis and gene set enrichment analysis of the transcriptome data from hsa_circ_0062682 knockdown explained the observed phenotypes and exposed transcription factors E2F1, Sp1, HIF-1α, and NFκB1 as potential downstream targets. Biotinylated oligonucleotide pulldown combined with proteomic analyses identified protein interaction partners of which YBX1, a known oncogene, was confirmed by RNA immunoprecipitation. Yes Stable perturbations of hsa_circ_0062682 in Huh-7 and SNU-449 cell lines influenced colony formation, migration, cell proliferation, sorafenib sensitivity, and additionally induced morphological changes in cell lines, indicating an important role of hsa_circ_0062682 in oncogenesis. 36139684 hsa_circ_0032683 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(microRNA-338-5p) qRT-PCR In GEO (Gene Expression Omnibus) database, hsa_circ_0032683 expression was significantly lower in HCC tissues than in normal liver tissues. Mechanically, hsa_circ_0032683 primarily exists in the cytoplasm and competes with microRNA-338-5p (miR-338-5p) to regulate reticulon 4(RTN4). Our experiments revealed that hsa_circ_0032683 receded the proliferation ability of HCC via ceRNA (competing endogenous RNAs) mechanism, which provided potential biomarkers and therapeutic targets for HCC patients. Yes In vitro and in vivo functional tests revealed that hsa_circ_0032683 could inhibit HCC cells proliferation and promote their apoptosis. 35030979 circITCH CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miR-184) qRT-PCR CircITCH (hsa_circ_0001141) was a stable circRNA and downregulated in HCC cells.. Mechanistically, miR-184 could be sponged by circITCH, and its overexpression could mitigate the suppressive effects of circITCH overexpression on HCC progression. Yes Overexpression of circITCH inhibited cell proliferation, migration, invasion, and promoted apoptosis in vitro and in vivo, whereas knockdown of circITCH had the opposite effects. 35400275 hsa_circ_0008285 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-384/RRM2 axis ) qRT-PCR Circ_0008285 expression is elevated to HCC tissues and cell lines.In this study, circ_0008285 could promote the malignant biological behaviors of HCC cells through miR-384/RRM2 axis and has the potential to become a therapeutic target for HCC, providing a new idea for targeted therapy of HCC. Yes Silencing of circ_0008285 inhibited the proliferation, migration and invasion of HCC cells but accelerated cell apoptosis in vitro and impeded HCC tumorigenesis in vivo. 35964907 hsa_circ_101555 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-145-5p/CDCA3) qRT-PCR hsa_circ_101555 showed greater stability than the linear RNA; while in vitro and in vivo results demonstrated that hsa_circ_101555 silencing significantly suppressed cell proliferation, migration, and invasion of HCC cells. Rescue experiments further demonstrated that suppression of miR-145-5p significantly attenuated the biological effects of hsa_circ_101555 knockdown in HCC cells. We also identified a putative oncogene CDCA3 as a potential miR-145-5p target. Yes hsa_circ_101555 showed greater stability than the linear RNA; while in vitro and in vivo results demonstrated that hsa_circ_101555 silencing significantly suppressed cell proliferation, migration, and invasion of HCC cells. 33824281 hsa_circ_0008305 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-660/BAG5 axis) qRT-PCR First, it was demonstrated that circ_0008305 was greatly increased in HCC tissues and cells. To sum up, it was illustrated by our study that circ_0008305-mediated miR-660-5p/BAG5 axis triggered HCC progression, which could provide a novel insight on the underlying mechanism of HCC progression. Yes Moreover, we observed silencing circ_0008305 markedly repressed HCC cells in vitro growth and reduced tumor growth in vivo. 33481351 hsa_circ_0046600 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-1258/SERBP1 ) qRT-PCR Circ_0046600 was highly expressed in HCC tissues and cells. Mechanistically, circ_0046600 could competitively target miR-1258 to prevent the degradation of its target gene SERBP1. Yes Silencing of circ_0046600 impaired HCC cell growth and metastasis in vitro, as well as impeded HCC tumor growth in vivo. 34784519 circMTO1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC and adjacent nontumor tissue Interaction( miR-541-5p/ZIC1 axis by regulating Wnt/β-catenin signaling pathway) CCK8//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC CircMTO1 is downregulated in HCC as compared to adjacent nontumor tissue, which may suppress the HCC progression by certain signal pathways.These findings indicated that circMTO1 suppressed HCC progression via the circMTO1/ miR-541-5p/ZIC1 axis by regulating Wnt/β-catenin signaling and epithelial-to-mesenchymal transition, making it a novel therapeutic target. Yes The results depicted that silencing circMTO1 or upregulating miR-541-5p expression facilitated HCC cell proliferation, migration, and invasion and inhibited apoptosis. CircMTO1 silencing upregulated the expression of downstream ZIC1 regulators of the Wnt/β-catenin pathway markers, β-catenin, cyclin D1, c-myc, and the mesenchymal markers N-cadherin, Vimentin, and MMP2, while the epithelial marker E-cadherin was downregulated. MiR-541-5p knockdown had the opposite effect and reversed the effect of circMTO1 silencing on the regulation of downstream ZIC1 regulators. 34930906 circRHOBTB3 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-18a ) qRT-PCR CircRHOBTB3 was under-expressed in HCC compared to normal tissues. In HCC cells, circRHOBTB3 overexpression decreased mature miR-18a level but not miR-18a precursor. Yes Cell proliferation analysis showed that circRHOBTB3 overexpression decreased cell proliferation while miR-18a overexpression increased cell proliferation. Moreover, circRHOBTB3 suppressed the role of miR-18a in cell proliferation. 34187598 circWHSC1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-142-3p/HOXA1 ) qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP CircWHSC1 was elevated in HCC tissues and cells, and high level of circWHSC1 was associated with worse overall survival of HCC patients.CircWHSC1 functioned as the sponge for miR-142-3p, which directly targeted HOXA1. Inhibition of miR-142-3p ameliorated the effects of circWHSC1 knockdown on HCC cell proliferation and metastasis. Moreover, miR-142-3p overexpression restrained the growth and motility of HCC cells, with HOXA1 elevation reversing the impacts. CircWHSC1 was elevated in HCC tissues and cells, and high level of circWHSC1 was associated with worse overall survival of HCC patients. Yes Knockdown of circWHSC1 suppressed HCC cell proliferation and metastasis in vitro and restrained tumorigenesis in vivo. 33410156 circC16orf62 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-138-5p/PTK2/AKT axis) qRT-PCR//Western Blot//Transwell Assay Bioinformation analysis and qRT-PCR indicated that CircC16orf62 was prominent upregulated in HCC of which the expression level was positively associated to cancer's malignant progression. The bioinformatic analysis found that miR-138-5p and PTK2 were the downstream target of CircC16or62. Then, the FISH(Fluorescence immunoin situ hybridization) and cell nucleoplasmic separation determined that CircC16orf62 located in the cell cytoplasm. CircC16orf62 functioned as a molecular sponge for miR-138-5p, and a competitive endogenous RNA for PTK2, promoting AKT/mTOR pathway activation. Bioinformation analysis and qRT-PCR indicated that CircC16orf62 was prominent upregulated in HCC of which the expression level was positively associated to cancer's malignant progression. Yes Gain or loss-of-function studies indicated that the reduction of CircC16orf62 expression promotes the proliferation, invasion, and glycolysis of HCC in vitro and in vivo. 34108451 circHPS5 CircRNA Homo sapiens Carcinoma, Hepatocellular CC tissues Interaction(miR-370/HMGA2 ) In Vivo Experiment//Western Blot//CCK8//Luciferase Report Assay//IHC The present study identified a circRNA with m6A modification, circHPS5, which was increased in neoplasm HCC tissues and indicated poor patient survival. Notably, METTL3 could direct the formation of circHPS5, and specific m6A controlled the accumulation of circHPS5. YTHDC1 facilitated the cytoplasmic output of circHPS5 under m6A modification. In addition, we demonstrated that circHPS5 can act as a miR-370 sponge to regulate the expression of HMGA2 and further accelerate HCC cell tumorigenesis. The present study identified a circRNA with m6A modification, circHPS5, which was increased in neoplasm HCC tissues and indicated poor patient survival. Yes Silencing of circHPS5 inhibited epithelial-mesenchymal transition (EMT) and cancer stem-like cell (CSC) phenotypes. 34703649 circFOXM1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miR-1179/SPAG5 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay Luciferase reporter gene activity assay showed that miR-1179 had complementary binding sites with circFOXM1 and SPAG5. CircFOXM1 silencing inhibited malignant phenotypes in HCC cells were partly rescued by either miR-1179 silencing or SPAG5 overexpression. CircFOXM1 promoted HCC cell proliferation and metastasis by regulating miR-1179/SPAG5 axis. Yes CCK8 assay, tumor volume and tumor weight showed that circFOXM1 effectively promoted HCC cell proliferation. Transwell assay showed that circFOXM effectively promoted migration and invasion abilities of HCC cells. 34903799 circUBAP2 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction( miR-194-3p/MMP9 pathway) Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay Among 91 HCC patients, circUBAP2 was significantly upregulated in HCC tissues, and negatively correlated with aggressive clinical characteristics and prognosis. Mechanistically, circUBAP2 acts as a competing endogenous RNA (ceRNA) for miR-194-3p, a tumor suppressor in HCC. We confirmed that MMP9 was direct target for miR-194-3p, which was regulated by circUBAP2. Among 91 HCC patients, circUBAP2 was significantly upregulated in HCC tissues, and negatively correlated with aggressive clinical characteristics and prognosis. Yes Functional assays demonstrated that circUBAP2 promoted cell proliferation, colony formation, migration, and invasion in vitro. Moreover, circUBAP2 enhanced tumor growth and pulmonary metastasis in vivo. 34239873 circTP63 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-155-5p/ZBTB18 ) In Vivo Experiment//CCK8//qRT-PCR//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay circTP63 was significantly upregulated in HCC tissues and cell lines. Mechanically, circTP63 was a sponge of miR-155-5p to facilitate the ZBTB18 expression, and the ZBTB18 expression in HCC tissues was negatively associated with the survival rate of HCC patients. High circTP63 expression is closely associated with the tumor stages, lymph node metastasis, and poor prognosis of HCC patients. Yes Functionally, knockdown of circTP63 inhibited cell proliferation, migration, invasion, and promoted cell apoptosis of HCC. Meanwhile, overexpression of circTP63 enhanced HCC progression. 33685441 hsa_circ_0097009 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-1261/SLC7A11 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Microarray analysis and qRT-PCR verified that circRNA, circ0097009, was significantly upregulated in HCC tissues and cell lines. Luciferase reporter assays showed that circ0097009 and SLC7A11 directly bound to miR-1261. Subsequent experiments showed that circ0097009 and SLC7A11 reciprocally regulated their expression via miR-1261 sponging by circ0097009. Yes Knockdown of circ0097009 inhibited the proliferation and invasion of HCC cells. 33987373 circSTIL CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-345-5p/AQP3 Axis) qRT-PCR Circ-STIL was upregulated in HCC tissues and cells. MiR-345-5p was a direct target of circ-STIL, and AQP3 was targeted by miR-345-5p in HCC. Circ-STIL knockdown or miR-345-5p overexpression impeded cell malignant behaviors in HCC cells, and the effects could be reversed by miR-345-5p silence or AQP3 enhancement, respectively. Meanwhile, circ-STIL regulated AQP3 expression by sponging miR-345-5p. Yes Circ-STIL knockdown inhibited HCC cell progression by reducing cell proliferation, migration and invasion and promoting cell apoptosis. Besides, circ-STIL downregulation retarded HCC tumor growth in vivo. 34231101 hsa_circ_0061395 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues, serum, cells, and serum-derived exosomes Interaction(miR-877-5p/PIK3R3 axis) Flow Cytometry//qRT-PCR//RIP//IHC//Transwell Assay Circ_0061395 was upregulated in HCC tissues, serum, cells, and serum-derived exosomes.MiR-877-5p was downregulated while PIK3R3 was upregulated in HCC. Circ_0061395 regulated PIK3R3 expression via competitively binding to miR-877-5p. MiR-877-5p inhibitor overturned circ_0061395 knockdown-mediated influence on malignant behaviors of HCC cells. PIK3R3 overexpression reversed the suppressive influence of miR-877-5p mimic on malignant behaviors of HCC cells. Yes Circ_0061395 silencing decreased tumor growth in vivo, and induced cell cycle arrest, apoptosis, repressed proliferation, invasion, and migration of HCC cells in vitro. 33407443 circZNF83 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miR-324-5p/CDK16-mediated JAK2/STAT3 signal ) qRT-PCR GL63 inhibited the circZNF83 expression in HCC cells. CircZNF83 served as a sponge of miR-324-5p and circZNF83/miR-324-5p axis was involved in the functional regulation of GL63 in HCC progression. Moreover, CDK16 was a downstream target of miR-324-5p and circZNF83 could regulate the CDK16 expression by sponging miR-324-5p. In addition, GL63 inactivated the JAK2/STAT3 pathway via downregulating circZNF83 to mediate the miR-324-5p/CDK16 axis. GL63 also repressed tumor growth in vivo through the circZNF83/miR-324-5p/CDK16-mediated JAK2/STAT3 signal inhibition. Yes CircZNF83 overexpression attenuated the inhibitory effects of GL63 on HCC cell growth, cell cycle progression, migration, and invasion but the promoting effect on cell apoptosis. 33982329 circRNF13 CircRNA Homo sapiens Carcinoma, Hepatocellular HBV-infected human HCC tissues and HBV-expressing cells (Huh7-HBV and Hep3B-HBV) Interaction(miR-424-5p/TGIF2) qRT-PCR First of all, real-time quantitative PCR (RT-qPCR) was utilized to examine RNA expression, and circ-RNF13 was upregulated in HBV-infected human HCC tissues and HBV-expressing cells (Huh7-HBV and Hep3B-HBV), accompanied with TGFβ-induced factor homeobox 2 (TGIF2) upregulation and microRNA (miR)-424-5p downregulation. In conclusion, circ-RNF13 might sponge miR-424-5p to suppress HBV-associated HCC cells malignant progression and HBV infection by regulating TGIF2, providing a novel insight into the occurrence and treatment of HBV-associated HCC. Yes As a result, blocking circ-RNF13 enhanced the apoptosis rate of Huh7-HBV and Hep3B-HBV cells, but inhibited cell proliferation, colony formation, migration, and invasion in vitro, along with suppressed tumor growth in vivo. 33714261 hsa_circ_0001588 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction( miR-874/CDK4 Signaling) qRT-PCR//Luciferase Report Assay//RIP//Western Blot Our current study is aimed at investigating the function of circ_0001588 in HCC, which was observed to significantly increase in HCC tissues and cells. Moreover, miR-874 was predicted as a target of circ_0001588. Using luciferase binding assays, we proved that circ_0001588 functions as a molecular ceRNA of miR-874 and that CDK4 acts as a downstream target of miR-874 in HCC. Yes We demonstrated that the knockdown of circ_0001588 resulted in repressed cell proliferation, migration, and invasion. In vivo studies using a nude mouse model showed that circ_0001588 downregulation reduced tumor size. 34722778 circPRKCI CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cell line Interaction(miR-1294 and miR-186-5p / FOXK1 ) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results of the present study revealed that miR-1294 and miR-186-5p expression levels were downregulated in the HCC cell line, HCCLM3, and were subsequently downregulated by circ-PRKCI overexpression and upregulated by the knockdown of circ-PRKCI. In addition, the overexpression of circ-PRKCI upregulated FOXK1 expression levels, while the overexpression of miR-1294 and miR-186-5p downregulated FOXK1 expression levels. Yes circ-PRKCI overexpression promoted the viability, invasion and migration of HCCLM3 cells, which was also reversed by the overexpression of miR-1294 and miR-186-5p. 33880589 hsa_circ_0001306 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-527/FBXW7) CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay//Transwell Assay Firstly, the downregulation of hsa_circ_0001306 was identified by high‑throughput RNA sequencing and further verified by qRT-PCR. Mechanistic studies indicated that hsa_circ_0001306 acts as a ceRNA for miR-527, which resulted in the reduction of its endogenous target, FBXW7. Yes Knockdown of hsa_circ_0001306 could downregulate F-box and WD repeat domain containing 7(FBXW7), a target of miR-527, thereby promoting HCC cell proliferation and invasion. Furthermore, hsa_circ_0001306 siRNA increased the multiplication rate of HCC tumors. 34659544 hsa_circ_0088364 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC patients' tumors Interaction(miR-1270-COL4A1 ceRNA pathway) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Expression of circ_0088364 and COL4A1 was upregulated, and miR-1270 was downregulated in HCC patients' tumors; moreover, there were linear correlations among circ_0088364, miR-1270, and COL4A1 expression. Essentially, circ_0088364 and COL4A1 were ceRNAs for miR-1270 via target binding. Yes In function, silencing circ_0088364 or upregulating miR-1270 could suppress cell proliferation, cell cycle entrance, transwell migration and invasion in Huh7 and HCCLM3 cells, as well as promote apoptosis rate. Moreover, above-mentioned effects were accompanied with reduced B-cell lymphoma (Bcl)-2, N-cadherin and Vimentin levels, and elevated Bcl-2-associated X protein (Bax) and E-cadherin levels. Contrarily, exhausting miR-1270 and restoring COL4A1 could severally abrogate the tumor-suppressive roles of circ_0088364 knockdown and miR-1270 overexpression in HCC cells in vitro. In vivo, silencing circ_0088364 retarded xenograft tumor growth in nude mice induced by Huh7 cells by upregulating miR-1270 and downregulating COL4A1. 34951563 circSOX4 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues or in cell lines Interaction(microRNA-432) Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay CircSOX4 was abnormally highly expressed either in HCC tissues or in cell lines, which was positively correlated with the poor prognosis of HCC patients. Bioinformatics analysis revealed that microRNA-432 contained the binding site pairing to circSOX4 3'UTR, and their binding relationship was confirmed by Luciferase assay. Their expression levels were negatively correlated. In addition, downregulation of microRNA-432 can partially reverse the effect of silenced circSOX4 on regulating apoptosis, proliferation and migration of HCC cells. CircSOX4 was abnormally highly expressed either in HCC tissues or in cell lines, which was positively correlated with the poor prognosis of HCC patients. Yes Transfection of small interfering RNA against circSOX4 in HCC cells resulted in inhibited migration and proliferation of HCC cells, while an increase in cell apoptosis. 33660794 circNOP10 CircRNA Homo sapiens Stomach Neoplasms GC tissue Interaction(miR-204/SIRT1 pathway) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Cell Apoptosis Assay//Microarray//Cell Cycle Assay//Transwell Assay The results indicated that increased circNOP10 in GC tissue was involved in tumor stage and prognosis. In addition, circNOP10 sponged microRNA-24 (miR-204)-mediated biological processes through sirtuin 1 (SIRT1), which further confirmed that the circNOP10/miR-204/SIRT1 pathway promoted proliferation and migration as well as epithelial-mesenchymal transition (EMT) through the NF-κβ pathway in GC cell lines. Yes In addition, circNOP10 sponged microRNA-24 (miR-204)-mediated biological processes through sirtuin 1 (SIRT1), which further confirmed that the circNOP10/miR-204/SIRT1 pathway promoted proliferation and migration as well as epithelial-mesenchymal transition (EMT) through the NF-κβ pathway in GC cell lines. 34532100 hsa_circ_0000751 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(microRNA-488) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//Invasion Assay//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//Microarray//Colony Formation Assay//EdU Staining//Transwell Assay The results showed that hsa_circ_0000751 levels were markedly downregulated in GC tissues and cell lines, which were also inversely proportional to the stage of tumor-node-metastasis (TNM) classification, tumor volume, and lymph node metastasis in GC patients. which were also inversely proportional to the stage of tumor-node-metastasis (TNM) classification, tumor volume, and lymph node metastasis in GC patients. Yes Conversely, hsa_circ_0000751 overexpression suppressed tumor progression, migration, and invasion in vitro and in vivo. From our results, we showed that hsa_circ_0000751 may serve as a miRNA sponge to suppress the activity of miR-488, thereby increasing the expression of the miR-488-target gene, UQCRC2, and limiting GC progression. 34565283 hsa_circ_0044516 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-149) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Viability Assay Upregulated circRNA_0044516 was found in GC tissues and cell lines. Yes Downregulating circRNA_0044516 inhibited the viability and promoted apoptosis of GC cells. CircRNA_0044516 targeted miR-149, and its downregulation elevated miR-149 level in GC cells. 33140323 CRNDE LncRNA Homo sapiens Precursor Cell Lymphoblastic Leukemia-Lymphoma bone marrow, cell lines regulation[ miR-345-5p/CREB Axis] RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay In this study, long non-coding RNA colorectal neoplasia differentially expressed (LncRNA CRNDE) was upregulated in the bone marrow of BCP-ALL patients and BCP-ALL cell lines (NALM-6 and RS4;11).In conclusion, LncRNA CRNDE upregulated CREB expression by suppressing miR-345-5p, thus promoting cell proliferation and reducing cell apoptosis in BCP-ALL. Yes Functionally, LncRNA CRNDE knockdown restrained cell proliferation and boosted cell apoptosis in NALM-6 and RS4;11 cells. 32868489 CRNDE LncRNA Homo sapiens Wilms Tumor tumor tissues regulation[ regulating microRNA-424] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay RT-qPCR results revealed that the expression level of lncRNA CRNDE in tumor tissues of patients with Wilms' tumor was remarkably higher than that of adjacent normal tissues. In addition, CRNDE might accelerate the progression of Wilms' tumor via modulating microRNA-424. Compared with patients with low expression of CRNDE, the risk of lymph node metastasis was significantly higher in patients with high CRNDE expression (p<0.05). Yes Similarly, compared with control group, the proliferation and metastasis abilities of cells in CRNDE knockdown group were remarkably down-regulated (p<0.05). However, opposite results were observed in CRNDE overexpression group. 32096178 CRNDE LncRNA Homo sapiens Liver Diseases, Alcoholic ALD tissues Expression(highly expressed) In Vivo Experiment Three lncRNAs (CRNDE, RBMS3-AS3, and LINC01088) were demonstrated to be potentially useful diagnostic markers in ALD. Among them, the expression of CRNDE is up-regulated. The result showed ALD tissues in mice had significantly higher CRNDE levels than normal tissues. Yes In addition, alcohol can induce apoptosis, and knockdown of CRNDE can reduce apoptosis. 34633988 CRNDE LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-455-3p/HDAC2 axis) Western Blot//Transfection//RIP//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The data revealed that the expression of CRNDE was upregulated in NSCLC tissues, while miR-455-3p was downregulated. Moreover, inhibition of miR-455-3p exhibited the opposite effect. CRNDE bound with miR-455-3p, and HDAC2 was found to be targeted by miR-455-3p. Meanwhile, miR-455-3p downregulation reversed the effect of CRNDE knockdown on NSCLC cell function. Furthermore, miR-455-3p notably inhibited the growth and invasion of NSCLC cells via downregulation of HDAC2. Knockdown of CRNDE attenuated NSCLC progression via modulation of the miR-455-3p/HDAC2 axis. Yes CRNDE knockdown inhibited the viability, migration and invasion of NSCLC cells or epidermal growth factor receptor gene (EGFR)-mutant NSCLC cells. 35611803 Crnde LncRNA Mus musculus Osteosarcoma Tumor tissues Interaction(miR-136-5p/MRP9 axis) Western Blot//ISH//Wound Healing Assay//CCK8//Luciferase Report Assay//Transwell Assay The expression of CRNDE in OS tissues was higher than that in normal tissues. High lncRNA CRNDE expression was significantly associated with clinical stage, lung metastasis, and poor prognosis in OS patients. Additionally, overexpression of lncRNA CRNDE promoted proliferation and migration of OS cells. Bioinformatics analysis showed that lncRNA CRNDE competitively inhibited miR-136-5p through acting as a competitive endogenous RNA (ceRNA). It was also revealed that miR-136-5p is a binding target gene of lncRNA CRNDE and that MRP9 is involved in this process as a downstream target gene of miR-136-5p. High lncRNA CRNDE expression was significantly associated with clinical stage, lung metastasis, and poor prognosis in OS patients. Yes Additionally, overexpression of lncRNA CRNDE promoted proliferation and migration of OS cells. 36034978 Crnde LncRNA Mus musculus Neuralgia spinal cord tissues Regulation[miR-136/IL6R axis ] RNA Pull-Down//Western Blot//RIP//Luciferase Report Assay//PCR//ELISA " As found, at postoperative days 3, 6, 9 and 12, CRNDE was increased in CCI rats compared to the sham group (Figure 1a).Overall, it was implied that CRNDE promoted neuropathic pain progression via modulating miR-136/IL6R axis in CCI rat models." Yes Interestingly, overexpression of CRNDE enhanced neuropathic pain behaviors. 31131445 CRLM1 LncRNA Homo sapiens Colorectal Neoplasms CRC cells and Balb/C nude mice Regulation ChIP//Western Blot//qRT-PCR//RIP//FISH//IF CRLM1 inhibited apoptosis of CRC cells and promoted liver metastasis in Balb/C nude mice. Yes CRLM1 inhibited apoptosis of CRC cells and promoted liver metastasis in Balb/C nude mice. 35907898 CREBBP CircRNA Homo sapiens Liver Cirrhosis epatic stellate cell Interaction(hsa-miR-1291/LEFTY2 Axis) Western Blot//qRT-PCR//PCR//Microarray//RNA Network For example, circCREBBP was significantly down-regulated in primary hepatic stellate cells (HSCs) and liver tissue of HF mice induced by CCl4 compared to those in the vehicle group. Mechanically, circCREBBP acts as a sponge for hsa-miR-1291 and subsequently promotes LEFTY2 expression. Yes Overexpression of circCREBBP with AAV8-circCREBBP in vivo prevented CCl4-induced HF worsening by reducing serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) contents, liver hydroxyproline levels, collagen deposition, and levels of pro-fibrosis genes and pro-inflammatory cytokines. Furthermore, in vitro function loss and function gain analysis showed that circCREBBP inhibited HSCs activation and proliferation. 34887753 CRCAL-3 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Expression[highly expressed] PCR As a result, analyses on TCGA datasets showed an upregulated CRCAL-3 expression in 14 solid tumors, including CRC. PCR assay on 253 cases of CRC tissue and 114 cases of normal adjacent tissue confirmed this expression upregulation. Also, CRCAL-3 expression was exhibited by survival analyses on the 253 CRC patients, to have a negative correlation with patients' overall and progression-free survivals. Yes In vitro knockdown of CRCAL-3 resulted in an obvious retardation of proliferation and migration in two CRC cell lines (HCT116 and DLD-1). Moreover, CRCAL-3 knockdown was observed in xenograft models to repress cell proliferation and enhance cisplatin sensitivity. 31038794 CRART16 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction(miR-122-5p/FOS axis) IHC//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//ELISA//Colony Formation Assay We found that CRART16 was substantially overexpressed in gastric cancer tissues compared with normal tissues, based on the TCGA database and our clinical samples. CRART16 was found to downregulate miR-122-5p by acting as a sponge, upregulating the target oncogene FOS. Afterward, the increased FOS expression led to the upregulation of VEGFD. High expression of CRART16 correlated with more advanced tumor stages and poor prognosis. Yes Overexpression of CRART16 in gastric cancer cells promoted proliferation, colony formation, angiogenesis, and bevacizumab resistance in vitro, and it promoted tumor growth and angiogenesis in vivo, and vice versa. 35537818 cRAPGEF5 CircRNA Homo sapiens Carcinoma, Renal Cell  RCC and adjacent nontumor tissues Interaction[miR-27a-3p/TXNIP pathway ] RIP//IP//qPCR//PCR In this study, we found cRAPGEF5 to be significantly downregulated in RCC tissues. In conclusion, cRAPGEF5 plays a role in suppressing RCC via the miR-27a-3p/TXNIP pathway and may serve as a promising prognostic biomarker and novel therapeutic target for RCC patients. Among 245 RCC cases, cRAPGEF5 downregulation correlated positively with aggressive clinical characteristics and independently predicted poor overall survival and recurrence-free survival. Yes Functional assays demonstrated that cRAPGEF5 suppresses RCC proliferation and migration in vitro and in vivo. 31629934 CR594175 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] CCK8//qRT-PCR//Invasion Assay//Western Blot We found that lncRNA-CR594175 was lower in adjacent non-cancerous tissues than in primary HCC, and was lower in primary HCC than in its metastasis. Yes Silencing of lncRNA-CR594175 inhibited the proliferation and invasion of HepG2 cells and growth of subcutaneous tumors. 32983253 CPS1-IT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Expression [lower expressed] qRT-PCR//Luciferase Report Assay//Western Blot Expression of CPS1-IT1 were significantly reduced, while HIF-1α and LC3-II were increased in CRC tissues and cell lines. Then, in vitro assays revealed that CPS1-IT1 suppresses EMT and autophagy by inhibiting the activation of HIF-1α in CRC. An in vivo animal model also demonstrated the tumor suppressor mechanism of CPS1- IT1. Yes Then, in vitro assays revealed that CPS1-IT1 suppresses EMT and autophagy by inhibiting the activation of HIF-1α in CRC. An in vivo animal model also demonstrated the tumor suppressor mechanism of CPS1- IT1. 29017924 CPS1-IT1 LncRNA Homo sapiens Glioma Glioma tissues Expression[lower expressed] CCK8//qRT-PCR//Transwell Assay In our study, we observed CPS1-IT1 levels were decreased in glioma tissues and cells compared with paired normal brain tissues and human astrocyte cell line, respectively. Moreover, we analyzed the associations of CPS1-IT1 expression with clinicopathological characteristics, and found low CPS1-IT1 expression was correlated with high World Health Organisation (WHO) grade and large tumor size in glioma patients. Survival analysis showed glioma patients in low CPS1-IT1 expression group had shorter overall survival than those in high CPS1-IT1 expression group, and low CPS1-IT1 expression was an independent prognostic factor for overall survival in glioma patients. Yes The in vitro studies suggested up-regulation of CPS1-IT1 expression resulted in the decrease of proliferation, migration and invasion abilities of glioma cells. In conclusion, CPS1-IT1 plays an anti-oncogenic role in glioma. 31545272 CPA4 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Expression[highly expressed] qRT-PCR Circ-CPA4 and PD-L1 were high-expressed, while let-7 miRNA was low-expressed in NSCLC cells and cancer tissues compared to the human bronchial epithelial (HBE) cells and their paired clinical normal adjacent tissues, respectively. Yes Besides, knock-down of circ-CPA4 inhibited cell growth, mobility and epithelial-mesenchymal transition (EMT), and promoted cell death in NSCLC cells by downregulating PD-L1 through serving as a RNA sponge for let-7 miRNA. 32746878 CP LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] CCK8//qRT-PCR//Western Blot//Transwell Assay Here, the expression of lncRNA AB073614 in CRC tissues was evaluated by quantitative real-time PCR (qRT-PCR). A difference analysis in the lncRNA AB073614 expression in CRC patient group suggested that the expression of lncRNA AB073614 was independently associated with higher possibilities of high grade (P = 0.0005), tumor size (> 5 cm) (P = 0.0001), distant metastasis (P = 0.0009), and differentiation level (P = 0.0037). Yes "In vitro studies demonstrated that the knockdown of {""type"": ""entrez-nucleotide"", ""attrs"":{""text"": ""AB073614"", ""term_id"": ""51555790"", ""term_text"": ""AB073614""}}AB073614 suppressed SW480 cell proliferation. Meanwhile, the overexpression of {""type"": ""entrez-nucleotide"", ""attrs"":{""text"": ""AB073614"", ""term_id"": ""51555790"", ""term_text"": ""AB073614""}}AB073614 in SW480 cells accelerated cell growth and invasion, and suppressed cell apoptosis." 31934121 CP LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissue Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR In present study, we demonstrated that lncRNA AB073614 was significantly Expression[Expression[up-expression]-expression]regulated in ovarian cancer tissues compared to adjacent normal tissues in patients. Yes Moreover, we demonstrated that lncRNA AB0736141 knockExpression[down-expression] sExpression[Expression[up-expression]-expression]pressed EOC cell proliferation ability and cell colony formation in vitro. In vivo, we showed that AB0736141 knockExpression[down-expression] sExpression[Expression[up-expression]-expression]pressed tumor growth. 30909184 COX7C-5 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-581/ZEB2 axis) IHC//Western Blot//Migration Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//Invasion Assay Here, we show that Lnc-COX7C-5 was significantly upregulated in HCC tissues, which was correlated with poor prognosis in HCC patients. Mechanistically, lnc-COX7C-5 function as a competing endogenous RNA (ceRNA) for miR-581 in HCC cells. Over-expression or knockdown of miR-581 could alter cell phenotypes caused by Lnc-COX7C-5 in HCC. Further investigations indicated that ZEB2 was demonstrated as a downstream target of miR-581. Here, we show that Lnc-COX7C-5 was significantly upregulated in HCC tissues, which was correlated with poor prognosis in HCC patients. Yes Lnc-COX7C-5 positively regulated proliferation, migration, and invasion of HCC cells. In mouse model, over-expression of Lnc-COX7C-5 facilitate lung metastasis of HCC. 36273755 cox-2 LncRNA Homo sapiens Carcinoma, Hepatocellular macrophages Expression [highly expressed] qRT-PCR The M1 macrophages had higher lncRNA cox-2 expression than that in the non-polarized macrophages and M2 macrophages. These findings indicate that lncRNA cox-2 inhibits HCC immune evasion and tumor growth by inhibiting the polarization of M2 macrophages. Yes The lncRNA cox-2 siRNA decreased the expression levels of IL-12, iNOS, and TNF-α in M1 macrophages, increased the expression levels of IL-10, Arg-1, and Fizz-1 in M2 macrophages (all P < 0.05). The lncRNA cox-2 siRNA reduces the ability of M1 macrophages to inhibit HCC cell proliferation, invasion, migration, EMT, angiogenesis and facilitate apoptosis while strengthening the ability of M2 macrophages to promote proliferation HCC cell growth and inhibit apoptosis. 29131381 CRNDE LncRNA Homo sapiens Leukemia, Promyelocytic, Acute Expression[highly expressed] qRT-PCR//Luciferase Report Assay We found that CRNDE was highly expressed in the disease state but not in the preleukemic stage of APL, suggesting that CRNDE might be a secondary event coordinating with PML/RARα to promote APL development. Yes Functional analysis showed that CRNDE knockdown induced differentiation and inhibited proliferation of APL cells, and prolonged survival of APL mice. 33298855 CRNDE LncRNA Homo sapiens Asthma neutrophils Regulation(NF-κB) Western Blot//Wound Healing Assay//Transfection//qRT-PCR//RIP//Luciferase Report Assay//ELISA//EdU Staining//Transwell Assay CRNDE was upregulated in LPS-EXO and successfully transferred from LPS-treated neutrophils to ASMCs through exosome. Mechanically, CRNDE loaded in LPS-EXO reinforced TAK1-mediated IKKβ phosphorylation, thereby activating the nuclear factor kappa B (NF-κB) pathway. In the end, the in vivo experiment demonstrated that CRNDE knockdown in neutrophils effectively reduced the thickness of bronchial smooth muscle in a mouse model for asthma. Yes Functionally, silencing CRNDE in LPS-EXO, an IKKβ inhibitor, and an NF-κB inhibitor all removed the upregulation of cell viability, proliferation and migration induced by LPS-EXO in ASMCs. 34590683 CORO1C CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC samples and cells Interaction(miR-654-3p/USP7 Axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//PCR//EdU Staining//IF Circ_CORO1C expression was elevated in LSCC samples and cells. USP7 is highly expressed in LSCC tissues and cells, and its expression was suppressed by circ_CORO1C silencing. Besides, the up-regulation of USP7 attenuated the influence of circ_CORO1C silencing on LSCC cell progression. Both circ_CORO1C and USP7 could bind to miR-654-3p. circ_CORO1C regulated USP7 expression by modulating miR-654-3p. miR-654-3p knockdown mitigated the influence of circ_CORO1C silence on LSCC cell progression. Yes circ_CORO1C silencing constrained cell proliferation and promoted apoptosis via reducing cell proliferation, inducing cell cycle arrest, inhibiting epithelial-mesenchymal transition, and promoting apoptosis, as well as restraining cell migration and invasion. Furthermore, circ_CORO1C silencing reduced tumor growth in vivo. 35064359 CRNDE LncRNA Homo sapiens Leukemia, Lymphocytic, Chronic, B-Cell MEC-1 and HG3 cells Interaction(miR-28/NDRG2 axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay Compared with normal B lymphocytes, CRNDE was down-regulated and the methylation level of CRNDE was increased in MEC-1 and HG3 cells. Moreover, CRNDE functioned as a competing endogenous RNA to repress miR-28, which controlled its down-stream target NDRG2. CRNDE overexpression inhibited cell proliferation and promoted apoptosis via miR-28/NDRG2 axis in CLL. Yes Then, 5-Aza-CdR treatment caused an increase of CRNDE expression in MEC-1 and HG3 cells by demethylation. The overexpression or demethylation of CRNDE inhibited cell proliferation and promoted apoptosis in MEC-1 and HG3 cells by up-regulating CRNDE expression. 33857783 CRNDE LncRNA Homo sapiens Leukemia, Myeloid, Acute AML and U937 cells Expression [highly expressed] CCK8//qRT-PCR The expression of lncRNA-CRNDE in patients with AML and U937 cells was significantly higher than that in non-malignant hematological controls. Meanwhile, after transfection of pcDNA-CRNDE, the proliferation ability of U937 cells increased significantly, which indicated that the expression of lncRNA-CRNDE might play an essential role in promoting the proliferation of U937 cells. Results of clinical data showed that the expression of lncRNA-CRNDE was associated with the classification and total survival of myeloid leukemia in clinical patients. Yes After transfection of siRNA-CRNDE, the proliferation and cloning ability of U937 cells decreased, while the apoptosis increased (p < 0.01) and cells were arrested in G0-G1 phase. Meanwhile, after transfection of pcDNA-CRNDE, the proliferation ability of U937 cells increased significantly, which indicated that the expression of lncRNA-CRNDE might play an essential role in promoting the proliferation of U937 cells. 29461608 CRNDE LncRNA Homo sapiens Uterine Cervical Neoplasms clinical tissues and cell lines interaction[PI3K/AKT] qRT-PCR//Western Blot This study confirmed that CRNDE is markedly up-regulated in clinical tissues and cell lines of cervical cancer. Loss-of-function assays revealed that CRNDE influences proliferation and apoptosis in cervical cancer cells, and Western blot assays revealed that the PI3K/AKT pathway was inactivated in response to CRNDE knockdown. The high expression of CRNDE positively correlates with advanced FIGO stage and lymph node metastasis. Furthermore, the overall survival rate in the group with highly expressed CRNDE was worse, and the high level of CRNDE may be regarded a prognostic factor because of its results from proportional hazard analysis. Yes Loss-of-function assays revealed that CRNDE influences proliferation and apoptosis in cervical cancer cells, and Western blot assays revealed that the PI3K/AKT pathway was inactivated in response to CRNDE knockdown. 30334449 CRNDE LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and adjacent non-cancerous tissues,cell lines(SiHa，HeLa，CaSki，Ms751，C33a,c4-1,Ect1 / E6E7) Interaction[suppressing PUMA ] RNA Pull-Down//Western Blot//RIP//qRT-PCR//Cell Viability Assay CRNDE expression was markedly increased in cervical cancer tissues compared to the corresponding non-cancerous tissues.Our study demonstrated that CRNDE, combined with PUMA, could be utilized as factor for the clinical diagnosis and prognosis of cervical cancer, and might be potential target for developing effective therapeutic strategy to prevent cervical cancer progression. Yes Through loss-of-function and gain-of-function approaches, we found that CRNDE knockdown markedly reduced cervical cancer cell proliferation, while CRNDE overexpression significantly promoted cervical cancer cell growth. Consistently, CRNDE decreasing obviously inhibited tumorigenicity of cervical cancer cells in vivo, whereas CRNDE increasing markedly promoted cervical cancer progression. 31202167 CRNDE LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines regulation[CRNDE/miR-183/CCNB1-axis] qRT-PCR//Luciferase Report Assay//Western Blot Systematic analyses of bioinformatics from several databases predicted that CRNDE, miR-183 and CCNB1 were in the same network path. Their expressions were up-regulated in CC tissues and cells.Our study highlighted a role for the CRNDE/miR-183/CCNB1-axis in CC and offered a promising diagnostic strategy for CC treatment. Yes Silencing CRNDE-inhibited cell proliferation, migration and invasion, restricted solid tumor growth and promoted cell apoptosis. 31605132 CRNDE LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells Interaction(miR-4262/ZEB1 Axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CRNDE and ZEB1 were up-regulated, while miR-4262 was down-regulated in cervical cancer tissues and cells. We found that CRNDE sponged miR-4262 and ZEB1 was a target of miR-4262. Furthermore, ZEB1 rescued the effects of miR-4262 overexpression or CRNDE deletion on cervical cancer progression. Yes miR-4262 inhibitor abolished CRNDE silencing-induced repression on cell proliferation, EMT, migration, invasion and promotion on cell apoptosis. 33469312 CRNDE LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction(miR-3163/TWIST1 Axis) In Vivo Experiment//IHC//Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Here, we discovered that CRNDE level was increased in NPC tissues and cell lines.Mechanically, CRNDE could serve as a molecular sponge of miR-3163 to regulate the expression of TWIST1. Additionally, elevated CRNDE positively correlated with large tumor size, advanced TNM stage, distant metastasis, EBV infection and worse prognosis. Yes Furthermore, depletion of CRNDE significantly impaired the capacity of proliferation, migration and invasion in NPC cells. 34796452 CRNDE LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues/cell lines Interaction(miR-545-5p/CCND2 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay This study demonstrated up-regulated expression of CRNDE and CCND2 within NPC tissues/cell lines. Meanwhile, miR-545-5p was down-regulated. All inhibiting functions generated by CRNDE down-regulation upon NPC progression could be counterbalanced or synergistically exacerbated, depending on miR-545-5p down-regulation or up-regulation, respectively. Multiple-level investigations revealed CRNDE to serve as a sponge for miR-545-5p, and can target CCND2 within NPCs. Yes CRNDE knock-down or miR-545-5p over-expression drastically reduced NPC proliferative, migrative and invasive properties, promoted apoptosis/altered cell cycle, and inhibited CCND2 expression. However, miR-545-5p down-regulation had opposing effects. 34863152 CRNDE LncRNA Homo sapiens Multiple Myeloma blood regulation[IL6 signalling pathway] qRT-PCR//MTT In this study, we have performed CRISPR-mediated deletion of the locus encoding the lncRNA Colorectal Neoplasia Differentially Expressed (CRNDE), a known oncogenic lncRNA that is overexpressed in plasma cells of MM patients and is a marker of poor prognosis.Altogether this study reveals the IL6 signalling pathway as a novel mechanism by which CRNDE impacts upon MM cell growth and disease progression. Yes We found that CRISPR-mediated deletion of the CRNDE locus in MM cells decreases proliferation and adhesion properties, increases sensitivity to Dexamethasone and reduces tumour growth in an in vivo xenograft model. 32879426 CRNDE LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues and cell lines Interaction(miR-451a/CDKN2D axis) In Vivo Experiment//Western Blot//Transfection//Tube Formation Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//ELISA//Colony Formation Assay//Transwell Assay The results showed that CRNDE was significantly up-regulated in pancreatic cancer tissues as well as cell lines. In addition, CRNDE was found to positively regulate CDKN2D expression and mediate pancreatic cancer cell proliferation and angiogenesis through miR-451a/CDKN2D axis. Yes CRNDE overexpression promoted the progression and angiogenesis of pancreatic cancer cells in vitro and in vivo. 33882369 CRNDE LncRNA Homo sapiens Osteoporosis, Postmenopausal osteoclast from patients with OP Expression[highly expressed] Flow Cytometry//qRT-PCR//MTT//Western Blot We found that the CRNDE was highly expressed in the osteoclast from patients with OP, compared with OH. Yes We also found that overexpressing CRNDE increased the viability in OH whilst reducing CRNDE in OP decreased the viability. The cell cycle was arrested in G0/G1 phase and the apoptosis rate was improved in OP after transfection with siRNA. 30280760 CRNDE LncRNA Homo sapiens Prostatic Neoplasms Pca tissues and cells regulation[miR-101/Rap1A] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay High expression of CRNDE was shown in Pca tissues and cells and predicted poor outcomes of patients. CRNDE contributed to cell proliferation, migration, and invasion by regulating the miR-101/Rap1A axis in Pca, providing a novel strategy for Pca treatment. High expression of CRNDE was shown in Pca tissues and cells and predicted poor outcomes of patients. Yes Overexpression of CRNDE promoted cell proliferation, migration, and invasion but decreased apoptosis in Pca cells, while its knockdown showed an opposite effect. 32182086 CRNDE LncRNA Homo sapiens Prostatic Neoplasms PC tissues Interaction(microRNA-146a-5p) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In PC tissues, the expression level of lncRNA CRNDE was upregulated. miR-146a-5p was verified as a direct target of lncRNA CRNDE. Moreover, the inhibition of miR-146a-5p partially counteracted the effects of lncRNA CRNDE on PC cell proliferation, migration, and invasion. Yes Moreover, knockdown of lncRNA CRNDE suppressed PC cell proliferation and migration and induced apoptosis in vitro. 34232111 CRNDE LncRNA Homo sapiens Colorectal Neoplasms HCT-116 cells Regulation(Akt/mTORC1 pathway) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry The results demonstrated that CRNDE inhibition decreased the proliferation and increased the apoptosis and cisplatin sensitivity of HCT-116 cells. In addition, CRNDE inhibition attenuated the Warburg effect in HCT-116 cells, as verified by a decrease in ATP production, lactic acid levels, glucose uptake, and the expression of Warburg effect-related enzymes (GLUT1, LDHA, HK2, and PKM2).CRNDE inhibition also suppressed the activity of the Akt/mTORC1 pathway, as demonstrated by the decreased phosphorylation of Akt, S6K, S6, and mTOR and the increased phosphorylation of 4EBP-1 and EIF-4E. Yes The results demonstrated that CRNDE inhibition decreased the proliferation and increased the apoptosis and cisplatin sensitivity of HCT-116 cells. In addition, CRNDE inhibition attenuated the Warburg effect in HCT-116 cells, as verified by a decrease in ATP production, lactic acid levels, glucose uptake, and the expression of Warburg effect-related enzymes (GLUT1, LDHA, HK2, and PKM2). 35069879 CRNDE LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and cell lines Regulation[PI3K/AKT/mTOR pathway] CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay The results showed CRNDE was upregulated in TSCC tissues and cell lines.In conclusion, high levels of CRNDE might promote TSCC progression at least partly through regulating the PI3K/AKT/mTOR pathway. Yes CRNDE knockdown repressed the proliferation, colony formation, migration and invasion and promoted apoptosis in TSCC cells. 35521355 CRNDE LncRNA Homo sapiens Inflammatory Bowel Diseases colitis tissues,cell lines (HT-29, LOVO, and Caco-2) Interaction[suppressing miR-495] qRT-PCR CRNDE and SOCS1 were highly expressed, but miR-495 was lowly expressed in the DSS-induced colitis tissues and colonic epithelial cell lines.The interaction between CRNDE and miR-495 was confirmed by RNA immunoprecipitation and RNA pull-down assay. The target relationship between miR-495 and SOCS1 was confirmed by the luciferase reporter assay. CRNDE promoted DSS-induced colonic epithelial cell apoptosis via miR-495/SOCS1. CRNDE interference in DSS-induced colitis mouse model alleviated clinical manifestations of IBD. Yes Interference of CRNDE inhibited cell apoptosis of DSS-induced colonic epithelial cells. 31251902 CRNDE LncRNA Homo sapiens Sepsis renal tissues Interaction[increasing MiR-181a-5p] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//ELISA We demonstrated that CRNDE was markedly down-regulated while miR-181a-5p was significantly up-regulated in sepsis models. For mechanism, miR-181a-5p directly targeted the 3' untranslated region of PPARα, and depressed its protein level, and PPARα was regulated indirectly by CRNDE. We concluded that CRNDE protected renal cell from sepsis-induced injury via miR-181a-5p/PPARα pathway. Yes Knockdown of CRNDE or transfection of miR-181a-5p significantly inhibited proliferation and promoted apoptosis of HK-2 and HEK293 cells, while overexpression of CRNDE and transfection of miR-181a-5p inhibitors had opposite effects. 31877497 CRNDE LncRNA Homo sapiens Neuroblastoma SH-SY5Y and SK-N-AS cells, neuroblastoma tissues Regulation( ERK/MAPK signaling pathway) Other The relative expression of CRNDE was significantly higher in neuroblastoma tissues than in the adjacent normal tissues. At the mechanistic level, western blotting showed that CRNDE exerted its oncogenic role by affecting the ERK/MAPK signaling pathway. Yes Moreover, knockdown of CRNDE inhibited tumor cell proliferation and induced apoptosis and cell cycle arrest, whereas elevation of CRNDE promoted cell growth and inhibited apoptosis in neuroblastoma cells. In addition, depletion of CRNDE suppressed migration and invasion, whereas overexpression of CRNDE enhanced the migratory and invasive potential of SH-SY5Y and SK-N-AS cells. Furthermore, animal experiments confirmed that CRNDE promotes tumor growth and inhibits apoptosis in neuroblastoma in vivo. 36564069 CRNDE LncRNA Homo sapiens Cholangiocarcinoma IHCC cell lines and tissues Expression [highly expressed] Western Blot//Transfection//Migration Assay//qRT-PCR//Cell Proliferation Assay//Invasion Assay Firstly, the relative expression of CRNDE was observed to be upregulated in IHCC cell lines and tissues. Mechanistically, CRNDE was revealed to facilitate the epithelial-mesenchymal transition (EMT) of IHCC cells. And high CRNDE expression was statistically associated with IHCC differentiation grade, lymph node metastasis, tumor-nodes-metastasis (TNM) stage and size. Survival analysis identified that high CRNDE expression is a predictor of worse overall survival (OS) and progression-free survival (PFS) in patients with IHCC. Yes Further studies of in vitro assays suggested that CRNDE silencing could suppress the proliferation of HuCCT1 cells following CCK-8 and colony formation assays, while CRNDE ectopic expression in HCCC9810 cells promoted proliferation. Moreover, the migration and invasion of HuCCT1 cells were greatly repressed with CRNDE deficiency following Transwell and Matrigel assays. Accordingly, the motility of HCCC9810 cells was notably accelerated with CRNDE overexpression. 29556285 COX10-DT LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(COX10-DT/miR-206/BDNF axis) Western Blot//Migration Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//BrdU//Cell Cycle Assay//Transwell Assay Clinically, we found that the lncRNA COX10-DT was commonly overexpressed in breast cancer tissues compared to paired peritumoural tissues. Mechanistically, the lncRNA COX10-DT did not play a role by regulating the expression of its divergent gene COX10 but acted as a competitive endogenous RNA (ceRNA) by directly sponging miR-206, which further regulated the expression of brain-derived neurotrophic factor (BDNF). Yes Functionally, the lncRNA COX10-DT might promote the proliferation and migration of breast cancer cells. 36463760 COMETT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[miR-339-5p-mediated regulation of CDK14] Western Blot//ISH//Wound Healing Assay//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//IHC//Transwell Assay Here we found that LINC01510 was highly expressed in NSCLC tissues.Furthermore, mechanistic studies revealed that LINC01510 exerted its oncogenic functions in NSCLC through miR-339-5p-mediated regulation of CDK14. Besides, Fisher's exact test showed that high expression of LINC01510 was associated with larger tumor size, advanced TNM stage and lymph node metastasis. Kaplan-Meier survival analysis showed that patients with high LINC01510 expression had a much lower overall survival rate. Yes Gain- and loss-of-function approaches were employed to investigate the effects of LINC01510 on NSCLC cell phenotypes. Functional studies demonstrated that LINC01510 over-expression promoted NSCLC cell proliferation, cell cycle progression, migration and invasion, but shRNA-mediated LINC01510 depletion inhibited NSCLC cell proliferation, cell cycle progression, migration and invasion. Notably, LINC01510 ablation suppressed tumorigenicity of NSCLC cells in a murine xenograft model. 30399588 cHP1BP3 CircRNA Homo sapiens Urinary Bladder Neoplasms BLCA tissue and YTS-1 cells Interaction( miR-1-3p) colony Formation Assay//Western Blot//ISH//Proliferation Assay//FISH//IF//Microarray//ELISA//Colony Formation Assay//Transwell Assay " cHP1BP3 was upregulated in BLCA tissues, and served as an miR-1-3p ""sponge"". " Yes cHP1BP3 was shown to modulate migratory ability, proliferation, and colony formation of YTS-1 cells, and displayed tumor-suppressing activity in BLCA. Target glycoproteins of C1GALT1, including integrins and MUC16, were identified. 35864552 ciRS-7 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines regulation[iR-7/EGFR axis] colony Formation Assay//Western Blot//Wound Healing Assay//qPCR//PCR//Colony Formation Assay//IF ciRS-7 was highly expressed in PTC tissues and cell lines compared with the corresponding controls. ciRS-7 was significantly upregulated in PTC tissues, and it promoted the progression of PTC by regulating the miR-7/EGFR axis. Yes In vitro study showed that ciRS-7 silencing suppressed proliferation, migration, and invasion of TPC-1 and BCPAP. 32685551 ciRS-7 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues Interaction(miR-432-5p/DNMT3B axis) Western Blot//ISH//Transfection//Flow Cytometry//qRT-PCR//RIP//FISH//PCR//IP//Transwell Assay//IF Higher ciRS-7 expression in LSCC tissues was closely associated with higher clinical stage, and exacerbated infiltration and lymph node metastasis in LSCC patients. When miR-432-5p was inhibited or DNMT3B was overexpressed, the growth and EMT of LSCC cells were stimulated despite ciRS-7 silencing. Downregulation of ciRS-7 restrained the growth of xenograft tumors in vivo. Higher ciRS-7 expression in LSCC tissues was closely associated with higher clinical stage, and exacerbated infiltration and lymph node metastasis in LSCC patients. Yes Silencing ciRS-7 inhibited LSCC cell viability, epithelial-mesenchymal transition (EMT), and promoted the apoptosis. 36356335 ciRS-7 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Expression[highly expressed] qRT-PCR//Western Blot ciRS-7 was overexpressed in ccRCC tissues compared with that in matched adjacent normal tissues. In addition, ciRS-7 up-regulation was closely associated with tumor diameter (P = 0.050), clinical stage (P = 0.009), and distant metastasis (P = 0.007). Yes ciRS-7 knockdown in 786O and 769P cells markedly inhibited their proliferative and invasive abilities. 32496306 ciRS-7 CircRNA Homo sapiens Arthritis, Rheumatoid 3 patients with RA and 3 healthy participants Interaction( miR-7) Transfection//RIP//PCR//IP//Invasion Assay//IF We identified distinct miRNA features in RA-FLS, including miR-7, which was significantly lower expressed. Furthermore, we discovered the negative regulatory relationship between ciRS-7 and miR-7 in RA-FLS. Finally, we overexpressed miR-7 in RA-FLS and discovered that miR-7 inhibited RA-FLS hyperproliferation, migration, invasion, and apoptosis, whereas ciRS-7 overexpression reversed these effects. Yes We identified distinct miRNA features in RA-FLS, including miR-7, which was significantly lower expressed. Furthermore, we discovered the negative regulatory relationship between ciRS-7 and miR-7 in RA-FLS. Finally, we overexpressed miR-7 in RA-FLS and discovered that miR-7 inhibited RA-FLS hyperproliferation, migration, invasion, and apoptosis, whereas ciRS-7 overexpression reversed these effects. 35752700 ciRS-7 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cells and tissues Interaction [miR-876-5p/MAGE-A ] colony Formation Assay//Western Blot//Wound Healing Assay//Colony Formation Assay//qRT-PCR//RIP//MTT//PCR//IP//IHC//Invasion Assay//IF Here, we showed that ciRS-7 is up-regulated in esophageal squamous cell carcinoma (ESCC), and is associated with the poor clinicopathological parameters of ESCC patients. Mechanistic studies revealed that ciRS-7 contains nineteen miR-876-5p binding sites and acts as a miR-876-5p sponge. Over-expression of ciRS-7 resulted in the reduced tumor-repressive function of miR-876-5p on its downstream target MAGE-A family. Here, we showed that ciRS-7 is up-regulated in esophageal squamous cell carcinoma (ESCC), and is associated with the poor clinicopathological parameters of ESCC patients. Yes Moreover, over-expression of ciRS-7 increased the proliferation, migration and invasion of ESCC cells. In animal experiments, enforced ciRS-7 increased ESCC tumor growth and metastasis through targeting miR-876-5p/MAGE-A family axis. 29635069 ciRs-6 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction[sponging miR-653 ] qPCR//CCK8//RNA-seq//PCR//IF ciRs-6 is expressed at low levels in cancer tissues and advanced tumor grades and stages, and its expression correlates with better outcomes for bladder cancer patients.In vitro and in vivo, ciRs-6 was shown to suppress bladder cancer growth by sponging miR-653 to elevate March1 levels. ciRs-6 is expressed at low levels in cancer tissues and advanced tumor grades and stages, and its expression correlates with better outcomes for bladder cancer patients. Yes In vitro and in vivo, ciRs-6 was shown to suppress bladder cancer growth by sponging miR-653 to elevate March1 levels. 31819015 CIRPIL LncRNA Mus musculus Myocardial Reperfusion Injury s I/R injury in mice Expression(lower expressed) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//FISH//IF The microarray screening identifies a down-regulated heart-enriched lncRNA-CIRPIL (Cardiac ischemia reperfusion associated p53 interacting lncRNA, lncCIRPIL) from the hearts of I/R mice. Cardiac-specific transgenic overexpression of lncCIRPIL alleviates I/R injury in mice, while knockout of lncCIRPIL exacerbates cardiac I/R injury. Yes LncCIRPIL inhibits apoptosis of cultured cardiomyocytes exposed to anoxia/reoxygenation (A/R). 35851102 CIRKIL LncRNA Homo sapiens Heart Injuries I/R myocardium, cardiomyocytes Interaction(Ku70) RNA Pull-Down//RIP The expression of CIRKIL was increased in I/R myocardium and H2O2-treated cardiomyocytes. Mechanistically, CIRKIL directly bound to Ku70 to subsequently decrease nuclear translocation of Ku70 and impair DNA double-strand breaks repair. Concurrent overexpression of Ku70 mitigated CIRKIL overexpression-induced myocardial I/R injury. Yes Overexpression of CIRKIL increased the expression of γH2A.X, a specific marker of DNA double-strand breaks and aggravated cardiomyocyte apoptosis, whereas knockdown of CIRKIL produced the opposite changes. Transgenic overexpression of CIRKIL aggravated cardiac dysfunction, enlarged infarct area, and worsened cardiomyocyte damage in I/R mice. Knockout of CIRKIL alleviated myocardial I/R injury. Furthermore, knockdown of human CIRKIL significantly suppressed cell damage induced by H2O2 in adult human ventricular cardiomyocytes and human induced pluripotent stem cell-derived cardiomyocytes. 35105170 cir-ITCH CircRNA Homo sapiens Prostatic Neoplasms PCa tissue,cell lines regulation[Wnt/β-catenin and PI3K/AKT/mTOR pathways] Western Blot//qPCR//Proliferation Assay//PCR//Cell Proliferation Assay//IF We found that cir-ITCH expression was typically downregulated in the tissues and cell lines of PCa compared to that in the peritumoral tissue and in RWPE-1 cells, respectively. Taken together, these data demonstrated that cir-ITCH plays a tumor-suppressive role in human PCa cells, partly through the Wnt/β-catenin and PI3K/AKT/mTOR pathways. Yes The results showed that cir-ITCH overexpression significantly inhibits the proliferation, migration, and invasion of human PCa cells and that reciprocal inhibition of expression occurred between cir-ITCH and miR-17. 32904490 circMAPK1 LncRNA Rattus norvegicus Atherosclerosis VSMCs Interaction(miR-22-3p/ methyl-CpG binding protein 2 axis) In Vivo Experiment//Wound Healing Assay//CCK8//qRT-PCR//RIP//RNA-seq//Luciferase Report Assay//Transwell Assay//IF Six circRNAs were up-regulated and 12 circRNAs were down-regulated in the atherosclerotic plaque tissues. Then we focused on circMAPK1, which showed a high level in atherosclerosis. Silencing circMAPK1 suppressed the proliferation and migration of VSMCs. Further study showed that circMAPK1 bound with miR-22-3p. CircMAPK1 silencing increased the level of miR-22-3p and suppressed the level of MECP2, a known target of miR-22-3p. Interestingly, suppression of miR-22-3p rescued the effect of circMAPK1 silencing on the proliferation and migration of VSMCs. Yes Silencing circMAPK1 suppressed the proliferation and migration of VSMCs. Further study showed that circMAPK1 bound with miR-22-3p. CircMAPK1 silencing increased the level of miR-22-3p and suppressed the level of MECP2, a known target of miR-22-3p. 34059381 cir-CCDC66 CircRNA Homo sapiens Hirschsprung Disease HSCR tissues Interaction[sponging miR-488-3p] qRT-PCR Thus, we discovered the cir-CCDC66 was downregulated in HSCR compared with the normal gut tissues. In conclusion, this is the first report revealing that cir-CCDC66 modulates DCX expression through sponging miR-488-3p and thus participates in the onset of HSCR. Yes The cir-CCDC66 reduction might inhibit cells' proliferation and migration in vitro. 30443988 cicrRNA_105040 CircRNA Homo sapiens Stomach Neoplasms GEO(GC tissues and matched normal tissues) Interaction(miR-324-5p/HMGA1 axis) RNA Pull-Down//Western Blot//ISH//qPCR//PCR//IF Hsa_circ_0091994 (cicrRNA_105040) was identified as a highly upregulated circRNA in GC tissues, whose host gene is negatively associated with the overall survival of patients. Bioinformatics analysis and a luciferase assays revealed that hsa_circ_0091994 knockdown inhibits GC progression by suppressing miR-324-5p and HMGA1 expression. Hsa_circ_0091994 knockdown inhibited the progression of GC by inhibiting the miR-324-5p/HMGA1 axis. Hsa_circ_0091994 (cicrRNA_105040) was identified as a highly upregulated circRNA in GC tissues, whose host gene is negatively associated with the overall survival of patients. Yes Using cell counting kit-8 and Annexin V assays, we observed that hsa_circ_0091994 knockdown inhibited the viability of AGS and HGC-27 cells by inducing apoptosis. Scratch wound healing assays showed that hsa_circ_0091994 knockdown also inhibited GC cell healing. The antitumor effect of hsa_circ_0091994 knockdown was confirmed in vivo using a mouse xenograft model. 34483139 cia-MAF CircRNA Homo sapiens Liver Neoplasms Liver cancer and liver TICs Expression [highly expressed] Northern Blot//Microarray Here, we have identified a functional circular RNA, termed circRNA activating MAFF (cia-MAF), that is robustly expressed in liver cancer and liver TICs. cia-MAF-KO primary cells and cia-maf-KO liver tumors harbor decreased ratios of TICs, and display impaired liver tumorigenesis, self-renewal, and metastatic capacities. In contrast, cia-MAF overexpression drives liver TIC propagation, self-renewal, and metastasis. Mechanistically, cia-MAF binds to the MAFF promoter, recruits the TIP60 complex to the MAFF promoter, and finally promotes MAFF expression. MAFF is highly expressed in liver tumors and liver TICs, and its antisense oligo (ASO) has therapeutic potential in treating liver cancer without MAFA/MAFG gene copy number alterations (CNAs). cia-MAF was highly expressed in liver cancer, and its expression levels were correlated with the clinical severity (Figure 1A), as well as tumor relapse (Figure 1B), patient prognosis (Figure 1C), Yes cia-MAF-KO primary cells and cia-maf-KO liver tumors harbor decreased ratios of TICs, and display impaired liver tumorigenesis, self-renewal, and metastatic capacities. 34403373 CHST15 CircRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell lines Interaction(miR-155-5p and miR-194-5p / PD-L1) colony Formation Assay//RNA Pull-Down//Western Blot//Transfection//qPCR//Flow Cytometry//PCR//ELISA//Colony Formation Assay//Bioinformatics Analysis//IF CircCHST15 and PD-L1 were high-expressed in lung cancer, and the two was positively correlated. CircCHST15 targeted miR-155-5p and miR-194-5p, the later further targeted PD-L1. Yes Lung cancer cell viability and proliferation were increased by miR-155-5p and inhibited by miR-194-5p. 33777742 Chrnb2 LncRNA Mus musculus Dry Eye Syndromes DED mice Regulation In Vivo Experiment//qRT-PCR//RNA-seq//Bioinformatics Analysis Chrnb2, Gabarapl2, and Usp31 were thereby confirmed as the most significantly altered lncRNAs. Pathway analysis revealed that the neuroactive ligand-receptor interaction signaling pathway was the most enriched, followed by the calcium signaling pathway and cytokine-cytokine receptor interaction. Yes Following treatment of Gabarapl2 siRNA and Chrnb2 siRNA, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 were significantly downregulated in the HCECs. 34957168 CHRF LncRNA Homo sapiens Stomach Neoplasms GC tissue regulation[EMT ] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay LncRNA CHRF expression was significantly higher in 103 GC tissue samples compared with the adjacent para-tumor samples. Yes Inhibition of lncRNA CHRF reduced the invasion and migration of MKN-7 cells while the over-expression of lncRNA CHRF promoted HGC-27 cells metastasis. 32096147 CHRF LncRNA Homo sapiens Prostatic Neoplasms cell line Interaction[microRNA-10b] qRT-PCR LncRNA CHRF promoted mesenchymal transition (EMT), showing down-regulation of E-cadherin and up-regulation of N-cadherin, vimentin and ZEB1. Afterwards, we found miR-10b expression was positively correlated with lncRNA CHRF expression, and miR-10b inhibition could reverse the effects of lncRNA CHRF on PC3 and LNCaP cell proliferation and EMT. Finally, lncRNA CHRF was found to activate the GSK3β/AKT and NF-κB pathways via up-regulation of miR-10b. LncRNA CHRF silence repressed proliferation and EMT while promoted apoptosis in PC3 cells via positive regulation of miR-10b. The GSK3β/AKT and NF-κB pathways were activated by lncRNA CHRF, possibly through up-regulation of miR-10b. Yes LncRNA CHRF silence repressed cell number (%), down-regulated expression of cyclinD1, CDK4 and CDK6, and promoted apoptosis along with activation of the casapse-3 and caspase-9. 30844757 CHRF LncRNA Homo sapiens Myocardial Reperfusion Injury myocardial I/R injury models Interaction(miR-182-5p/ATG7 pathway) RNA Pull-Down//Western Blot//Transfection//Tunel//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//IF In our current work, we found that the expression of CHRF was upregulated in myocardial I/R injury models. To sum up, our results suggested that CHRF exacerbated myocardial I/R injury by enhancing autophagy via modulation of the miR-182-5p/ATG7 pathway. Yes Suppression of CHRF relieved myocardial I/R injury in vivo. In addition, in vitro silencing of CHRF enhanced cell viability and attenuated lactate dehydrogenase activity (LDH) as well as apoptosis in H9C2 cells treated with hypoxia/reoxygenation injury. Autophagy has been studied to play an important role in myocardial I/R injury. Thus, experiments related to autophagy were done, and the results showed that CHRF knockdown decreased autophagy. 33491285 CHRF LncRNA Mus musculus Cerebral Ischemia/Reperfusion Injury brain tissue Regulation[miR-126/SOX6 signaling pathway] Transfection//Immunoblotting//Tunel//qRT-PCR//Luciferase Report Assay//IF In this study, we found that CHRF was significantly correlated with miR-126, and miR-126 expression was decreased in the ischemic core following ischemia, while CHRF expression was increased according to the in vivo and in vitro experiments. Moreover, CHRF played as a competing endogenous RNA (ceRNA) and competed with Sex-determining region Y box 6 (SOX6) to direct binding with miR-126, subsequently regulating ischemic neuronal death. CHRF knockdown in vivo markedly prevented ischemic damage and alleviated neurological dysfunctions. Yes CHRF knockdown in vivo markedly prevented ischemic damage and alleviated neurological dysfunctions. 31060778 ciRS-7 CircRNA Homo sapiens Pancreatic Neoplasms PDAC tissues Regulation[EGFR/STAT3 signaling pathway] qRT-PCR//MTT//PCR//Western Blot ciRS-7 expression was significantly higher in PDAC tissues than paracancerous tissues (P = 0.002). Furthermore, ciRS-7 knockExpression[down-expression] sExpression[Expression[up-expression]-expression]pressed cell proliferation and invasion of PDAC cells (P < 0.05), and the Expression[down-expression]regulation of ciRS-7 resulted in miR-7 overexpression and subsequent inhibition of epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3). Yes Furthermore, ciRS-7 knockExpression[down-expression] sExpression[Expression[up-expression]-expression]pressed cell proliferation and invasion of PDAC cells (P < 0.05), and the Expression[down-expression]regulation of ciRS-7 resulted in miR-7 overexpression and subsequent inhibition of epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3). 30898507 ciRS-7 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines regulation[MAPK/AKT signaling pathways] qPCR//Western Blot//PCR//IF We found that ciRS-7 was highly expressed in OSCC tissues and cell lines compared with normal counterparts. Our results suggested that ciRS-7 can interact directly with miR-7, resulting in upregulation of RAF-1/PIK3CD expression and enhancing metastatic progression of OSCC. Yes Ectopic expression of ciRS-7 significantly promoted OSCC cell proliferation, migration and invasion through in vitro and in vivo. 32956704 COMETT LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation(MET) Western Blot//ISH//qRT-PCR//MTT//Colony Formation Assay In the present study, we found that LINC01510 was significantly upregulated in CRC tissues and cell lines. Further study indicated that LINC01510 was positively correlated with the expression of MET, and its effects were most likely at the transcriptional level. The LINC01510 expression level were associated with the clinicopathological grade and stage. Yes Meanwhile, gain- and loss-of-function assays demonstrated that LINC01510 overexpression increased CRC cell proliferation, and promoted cell cycle progression from the G1 phase to the S phase. 29581707 CiRS-7 CircRNA Homo sapiens Ovarian Neoplasms OC cells and tissues regulation[ciRS-7/miR-641/ZEB1 or ciRS-7/miR-641/MDM2 axis] IP//qPCR//PCR CiRS-7 expression was significantly higher in OC cells and tissues, Targeting ciRS-7/miR-641/ZEB1 or ciRS-7/miR-641/MDM2 axis may be a novel diagnostic, prognostic and therapeutic strategy for OC. CiRS-7 expression was significantly higher in OC cells and tissues, which was significantly associated with the TNM stages, lymph node metastasis status and overall survival rate in OC patients. Yes CiRS-7 silence inhibited OC cell growth and metastasis. 32667627 COMETT LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines Interaction[modulating miR-335/SHH and activating Hedgehog pathway] RNA Pull-Down//ChIP//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay In this study, we firstly reported that LINC01510 was highly expressed in both PTC tissues and cell lines. Moreover, down-regulation of LINC01510 resulted in accelerated apoptosis by promoting the expression of Caspase3/9. In particular, LINC01510 acted as an endogenous sponge by directly binding miR-335, resulting in the suppression of miR-335 expressions. Besides, we confirmed that SHH was a target of miR-335 and miR-335 over-expression distinctly reduced SHH expression in PTC cells. Finally, in the cytoplasm, we provided evidenced that LINC01510 acted as a sponge for miR-335, reducing its ability to promote SHH expression. In addition, the results of Western blot indicated that knockdown of LINC01510 inhibited the expression of SHH and GLI1, suggesting that Hedgehog pathway was suppressed. Taken together, our findings revealed that the newly identified LINC01510/miR-335/SHH axis could be a therapeutic target for PTC. Yes Functional assays with a series of cell experiments indicated that knockdown of LINC01510 suppressed the proliferation, migration and invasion of SW1736 and TPC-1 cells. 31590919 COMETT LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines Regulation[Wnt/β-catenin signaling] qRT-PCR Moreover, the down-regulated LINC01510 was further confirmed in our fresh tissues and cell lines.Taken together, we found that LINC01510 regulates cell proliferation and invasion by modulating Wnt/β-catenin signaling in RCC. Yes Biological functions assays shown that Ectopic expression of LINC01510 not only inhibits RCC cell proliferation both in vitro and in vivo, but also impairs cell invasion ability. 30224058 COL4A2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell line Interaction(miR-20b-5p/HIF1A axis) qRT-PCR//RIP The data revealed an upregulated expression of COL4A2-AS1 in CRC tissues and cell lines than paired adjacent tissues and normal cell line.In CRC cells, miR-20b-5p was sponged by COL4A2-AS1 and hypoxia-inducible factor 1 alpha subunit (HIF1A). Restoration of HIF1A expression reversed the inhibitory effects of silencing COL4A2-AS1 on aerobic glycolysis and proliferation of CRC cells. Yes Silencing COL4A2-AS1 inhibited proliferation, aerobic glycolysis, and promoted apoptosis of CRC cells in vivo and in vitro. However, overexpression of COL4A2-AS1 significantly promoted CRC cell proliferation and aerobic glycolysis. 34477476 COL1A1-014 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Regulation[CXCL12-CXCR4 axis ] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that COL1A1-014 was frequently upregulated in GC tissues as well as cells. Overexpression of COL1A1-014 increased the mRNA expression of chemokine (CXCmotif) ligand (CXCL12) and high levels of CXCL12 and CXCR4 proteins in GC cells. The levels of miR-1273h-5p showed an inverse correlation with COL1A1-014 and CXCL12 in GC cells transfected with miR-1273h-5p. The mRNAs of wild-type COL1A1-014 and CXCL12 showed reduction in HEK293 cells transfected with miR-1273h-5p. This suggested that COL1A1-014 functions as an efficient miR-1273h-5p sponge and as a competing endogenous RNA (ceRNA) to regulate CXCL12. The proliferative activity of COL1A1-014 on GC cells was blocked by CXCL12-CXCR4 axis inhibitor AMD-3100. Yes COL1A1-014 increased cell proliferation, colony forming efficiency, migration ability, invasion ability, and weight and volume of grafted tumors, while reduced cell apoptosis. 31650323 COL18A1-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cells Interaction(miR-1286/KLF12 axis) In Vivo Experiment//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//IHC//IF "In this study, we found lncRNA COL18A1-AS1 was downregulated in ccRCC and that higher COL18A1-AS1 expression indicated better prognosis. Decreased COL18A1-AS1 expression was caused by DNA methylation at the CpG islands within its promoter. Mechanistically, COL18A1-AS1 could competitively bind miR-1286 to increase the expression of Krüppel-like factor 12 (KLF12). Downregulation of COL18A1-AS1 in ccRCC resulted in the low expression of KLF12. COL18A1-AS1/KLF12 positively regulated uncoupling protein 1 (UCP1)-mediated lipid browning, which promotes tumor cell ""slimming"" and inhibits tumor progression. When tumor cell ""slimming"" occurred, lipid droplets turned into tiny pieces, and lipids were consumed without producing ATP energy. " Yes Restoring the epigenetically silenced COL18A1-AS1 repressed tumor progression, promoted lipid browning and consumption in vitro and in vivo. 35787628 CNOT2 CircRNA Homo sapiens Breast Neoplasms BC tissues Interaction(miR-153-3p/ANLN Axis) Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The results assured that circCNOT2 and Twist Family BHLH Transcription Factor (TWIST1) were elevated in BC, while microrNA (miR)-409-3p was reduced. CircCNOT2 was positively correlated with TWIST1 and negatively correlated with miR-409-3p. Elevated circCNOT2 is associated with poor prognosis of BC. Yes Knockdown circCNOT2 or augmented miR-409-3p could promote apoptosis but repress proliferation, invasion, migration and EMT of BC cells. In addition, overexpression of circCNOT2 or TWIST1 accelerated BC invasion, migration and EMT, which could be reversed by simultaneous transfection of miR-409-3p-mimic.  34698000 CNALPTC1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-6788-5p/PAK1 pathway) Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The elevated expression level of CNALPTC1 was observed in GC tissues and cell lines. In addition, we observed that CNALPTC1 functions as a molecular sponge for miR-6788-5p, and the level of expression of CNALPTC1 exhibited a negative correlation with miR-6788-5p. Moreover, it was revealed that the miR-6788-5p's direct target was PAK1, which could reverse the inhibitory function of miR-6788-5p. Yes The in vitro analysis indicated that gene silencing of CNALPTC1 resulted in inhibition, whereas upregulation of CNALPTC1 resulted in the promotion of invasion, proliferation, and migration of GC cells, respectively. 36636079 cMras CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction[miR-567/PTPRG regulatory pathway] Western Blot//qRT-PCR//PCR//IP//IF Thirty-six paired LUAD and healthy tissues were collected and cMras resulted significantly downregulated in cancerous tissues. Bioinformatics analysis and experimental evidence confirmed that cMras was a sponge of miRNA-567 and released its direct target, PTPRG. cMras overexpression decreased miR-567 expression and subsequently increased PTPRG expression, while increased miRNA-567 expression blocked the effects induced by cMras. Moreover, PTPRG was downregulated in LUAD and patients with low PTPRG expression exhibited significantly poor prognosis. These results suggested that cMras/miR-567/PTPRG regulatory pathway might be associated to LUAD tumorigenesis and development. Thirty-six paired LUAD and healthy tissues were collected and cMras resulted significantly downregulated in cancerous tissues. Its expression was negatively associated with tumour stages. Yes cMras overexpression suppressed LUAD growth and metastasis, while endogenous cMras silencing resulted in the opposite effects. 31012177 cMras CircRNA Homo sapiens Adenocarcinoma of Lung LAC tissues and cells regulation[ABHD5/ ATGL Axis Using NF-κB Signaling Pathway] Western Blot//qPCR//Flow Cytometry//MTT//PCR Low levels of circ_cMras, ABHD5, and ATGL were observed in LAC tissues and cells.Circ_cMras exerted its function through ABHD5/ATGL axis using NF-κB signaling pathway in LAC, which might provide a novel insight for the diagnosis and prognosis of LAC. Yes Upregulation of circ_cMras could hamper tumor aggression in vitro and in vivo, exhibiting as the inhibition of cell proliferation, migration, invasion, and promotion of cell apoptosis, as well as the inhibition on tumor growth in vivo. 32822232 CLSPN CircRNA Homo sapiens Glioblastoma GBM tumor tissues and cells Interaction(miR-370-3p-USP39 pathway) RNA Pull-Down//Western Blot//Transfection//qPCR//Flow Cytometry//RIP//IF//PCR//IP//Transwell Assay First, we examined expression of circCLSPN using GSE109569 database and RT-qPCR, and circCLSPN level was upregulated in human GBM tumor tissues and cells (A172 and LN18); moreover, circCLSPN showed a stable structure stability. According to dual-luciferase reporter assay and RNA pull-down assay, miR-370-3p was identified to be targeted and sponged by circCLSPN, and further targeted and negatively regulated USP39. Yes Consequently, circCLSPN silencing suppressed cell viability, colony formation ability, cell cycle progression, migration, and invasion of A172 and LN18 cells in vitro, and promoted apoptosis rate. Allied with those were decreased B cell lymphoma-2 (Bcl-2), matrix metalloproteinase-2 (MMP2) and MMP9 expression, and elevated Bcl-2-associated X protein (Bax) level. 34269180 CLRN1-AS1 LncRNA Homo sapiens Prolactinoma pituitary prolactinoma tissues Regulation[Wnt/β-catenin signaling pathway] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Microarray//Colony Formation Assay//EdU Staining//ChIP LncRNA clarin 1 antisense RNA 1 (CLRN1-AS1) was downregulated in 42 patient samples and inactivated the Wnt/β-catenin signaling pathway. In summary, this study revealed that FOXP1-induced CLRN1-AS1 regulated cellular functions in pituitary prolactinoma by sponging miR-217 to release the DKK1/Wnt/β-catenin signaling pathway. Yes Functionally, CLRN1-AS1 suppressed cell proliferation, promoted apoptosis, and inhibited autophagy. 31235696 CKMT2-AS1 CircRNA Homo sapiens Colorectal Neoplasms Cell lines Regulation(AKT/mTOR Signaling Pathway) qRT-PCR//Western Blot We found CKMT2-AS1 was the most significant=0.0105 for SW480 and P=0.0071 for HCT116) difference lncRNA between colorectal cancer treated with autophagy inducer and colorectal cancer without any treatment. Furthermore, we found the phosphorylation of mTOR, AKT was enhanced in SW480, and HCT116 cells treated with autophagy inducer + shRNA-CKMT2-AS1 compared to the cells treated with autophagy inducer of autophagy inducer + shRNA-NC. Yes Following, we found the treatment of autophagy inducer and autophagy inducer + shRNA-NC were able to suppress the proliferation of both SW480 and HCT116 cells. In addition, the treatment of autophagy inducer + shRNA-CKMT2-AS1 significantly reduced the apoptosis of SW480 and HCT116 cells induced by autophagy. 35866106 cis-HOX CircRNA Homo sapiens Colorectal Neoplasms colorectal tumor-initiating cells Interaction(HOXC10) Northern Blot//Western Blot//IF//PCR//IP//Transwell Assay Here we find that cis-HOX (circular RNA stabilizing HOXC10) is robustly expressed in colorectal tumor-initiating cells (TICs). Mechanistically, cis-HOX binds to HOXC10 mRNA to attenuate its decay through blocking the K-homology splicing regulatory protein (KSRP)-binding sequence of HOXC10 3' UTR. HOXC10 is highly expressed in colorectal tumors and TICs and triggers Wnt/β-catenin activation by activating FZD3 expression. Yes cis-HOX knockout decreases colorectal TIC numbers and impairs the self-renewal, tumorigenesis, and metastatic capacities of TICs, whereas cis-HOX overexpression drives colorectal TIC self-renewal and metastasis. 34320348 CiRS-7 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction( ciRS-7/miR-7/NF-kB axis ) Western Blot//Transfection//qPCR//MTT//PCR//IF Moreover, remarkably up-regulated ciRS-7 and RELA expressions, as along with down-regulated miR-7 expressions, were found within NSCLC tissues and cells in comparison with normal ones (P < .05). More than that, ciRS-7 specifically targeted miR-7 to reduce its expressions (P < .05). Ultimately, the NSCLC cells within miR-7 + RELA group were observed with superior proliferative, migratory and invasive capabilities than those within miR-7 group (P < .05), and RELA expression was also significantly modified by both ciRS-7 and miR-7 (P < .05). In conclusion, the ciRS-7/miR-7/NF-kB axis could exert pronounced impacts on the proliferation, migration, invasion and apoptosis of NSCLC cells. Yes Besides, overexpressed ciRS-7 and underexpressed miR-7 were correlated with increased proliferation, migration and invasion, yet reduced apoptosis rate of NSCLC cells (P < .05). 29532994 ciRS-7 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cancer tissues Regulation[miR-7/HOXB13] colony Formation Assay//Western Blot//PCR//Colony Formation Assay//IF In this study, we found that the ciRS-7 expression was significantly upregulated in ESCC cancer tissues compared with matched normal tissues and associated with poor patient survival.Mechanistically, ciRS-7 functioned as the sponge of miR-7 and reactivated its downstream HOXB13-mediated NF-κB/p65 pathway. In this study, we found that the ciRS-7 expression was significantly upregulated in ESCC cancer tissues compared with matched normal tissues and associated with poor patient survival. Yes Overexpression of ciRS-7 abrogated the tumor-suppressive roles of miR-7 including cell proliferation, migration and invasion in vitro as well as tumor growth and lung metastasis in vivo. 30082829 ciRS-7 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissue Interaction[miR-7/KLF4 and NF-κB signals] qRT-PCR//Western Blot The expression of ciRS-7 was significantly increased in the ESCC tissues and cells as compared with their corresponding controls.Over expression of miR-7, one of well-known targets of ciRS-7, can attenuate ciRS-7 induced invasion of ESCC cells and over expression of matrix metalloproteinase 2 (MMP2). The expression of stem cell marker KrExpression[Expression[up-expression]-expression]pel-like factor-4 (KLF-4), which has been reported as the target of miR7, increased significantly in ciRS-7 transfected ESCC cells. KnockExpression[down-expression] of KLF-4 also attenuated over expression of ciRS-7 induced cell invasion. In addition, BAY 11-7082, the inhibitor of NF-κB, partially reversed ciRS-7 induced cell invasion. Mechanically studies indicated that ciRS-7 increased the expression of p65 via increasing the phosphorylation of IKK-α. Yes In vitro study showed that ciRS-7 can promote the migration and invasion of ESCC cells. 30207835 ciRS-7 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tumor tissues and cell lines Interaction(miR-139-3p/TAGLN axis and activating the PI3K/AKT signaling pathway) PCR "ciRS-7 was highly expressed in RCC tumor tissues and cell lines, and high ciRS-7 expression correlated with tumor size, high Fuhrman grade and poor survival. Depletion of ciRS-7 significantly inhibited RCC cell proliferation, invasion, tumor growth and metastasis in vivo, while overexpression of ciRS-7 had the opposite effect. Mechanistically, ciRS-7 acts as a ""ceRNA"" for miR-139-3p to prevent TAGLN degradation and promoting RCC progression and metastasis via the PI3K/AKT signaling pathway. In addition, miR-139-3p mimics or inhibitor could reverse the altered malignant tumor behavior caused by ciRS-7 overexpression or silencing. Furthermore, the PBAE/siciRS-7 nanocomplexes could significantly inhibit RCC tumor progression and metastasis in vivo. ciRS-7 acts as a tumor promoter by regulating the miR-139-3p/TAGLN axis and activating the PI3K/AKT signaling pathway to promote RCC progression and metastasis. Drug development of PBAE/si-ciRS-7 nanocomplexes targeting ciRS-7 may represent a promising gene therapeutic strategy for RCC." Yes In addition, miR-139-3p mimics or inhibitor could reverse the altered malignant tumor behavior caused by ciRS-7 overexpression or silencing. 34740354 ciRS-7 CircRNA Homo sapiens Osteoarthritis blood Regulation[ciRS-7/miR-7 axis ] Western Blot//qRT-PCR//MTT//PCR//ELISA Decreased ciRS-7 expression and increased miR-7 expression were observed in OA blood samples. These findings demonstrate that the ciRS-7/miR-7 axis can possibly serve as a regulator in mediating proliferation, apoptosis and inflammation in chondrocytes in the process of OA development. Yes Transfection of ciRS-7 siRNA and miR-7 mimic enhanced the impact of IL-1β on inflammatory cytokine release and cell apoptosis as quantified using ELISA and flow cytometry. Conversely, ciRS-7 cDNA and miR-7 inhibitor induced the reverse effect. 30925324 ciRS-7 CircRNA Homo sapiens Carcinoma, Hepatocellular cells and tissues Interaction(miR-944/NOX4 Pathway) RNA Pull-Down//Western Blot//qRT-PCR//PCR//IF The results showed that ciRS-7 was highly expressed in both hepatocellular carcinoma cells and tissues. Further study showed that ciRS-7 regulated the miR-944 level through acting as a microRNA sponge. q-RT-PCR, Western blot, RNA pull-down and dual luciferase activity assays showed that miR-944 targeted and regulated the expression of NOX4. Yes Overexpression of ciRS-7 could promote the proliferation, migration, and invasion of HCC. 36004692 CRNDE LncRNA Homo sapiens Osteosarcoma OS tissues Interaction(miR-335-3p) CCK8//qRT-PCR lncRNA CRNDE expression was upregulated and miR-355-3p expression was downregulated in OS. We revealed that miR-335-3p was the target of lncRNA CRNDE. In patients with OS, low lncRNA CRNDE expression demonstrated higher overall survival, whereas high lncRNA CRNDE expression was an independent poor prognostic factor. Yes It also demonstrated that knockdown of lncRNA CRNDE inhibited OS cell proliferation, migration, and invasion, and inhibition of miR-355-3p promoted this effect. Finally, miR-335-3p partially mediated the stimulatory effects of lncRNA CRNDE in OS. 33522065 CRNDE LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines regulation[Wnt/β-catenin signaling pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay The results demonstrated that the expression of CRNDE was high in OS tissues and cell lines, and partly induced by SP1.The mechanistic investigations showed that CRNDE promoted glycogen synthase kinase-3β phosphorylation to activate the Wnt/β-catenin pathway. Yes CRNDE knockdown attenuated OS cell proliferation and invasion and induced apoptosis and G0/G1 arrest. 31898343 CRNDE LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck CD8 + T cells Interaction(miR-545-5p and TIM-3) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Here, CRNDE was obviously elevated and negatively correlated with IFN-γ production in tumour-infiltrating CD8 + T cells isolated from OSCC patients. Mechanistically, CRNDE specifically sponged miR-545-5p to induce T-cell immunoglobulin and mucin domain-3 (TIM-3), thus contributing to CD8 + T-cell exhaustion. TIM-3 is a significant immune checkpoint, and it inhibits cancer immunity. TIM-3 can demonstrate an important role in CD8 + T-cell exhaustion. In summary, loss of CRNDE could induce miR-545-5p and inhibit TIM3 expression, thus significantly activated the anti-tumour effect of CD8 + T cells. Yes TIM-3 is a significant immune checkpoint, and it inhibits cancer immunity. TIM-3 can demonstrate an important role in CD8 + T-cell exhaustion. In summary, loss of CRNDE could induce miR-545-5p and inhibit TIM3 expression, thus significantly activated the anti-tumour effect of CD8 + T cells. 34729919 CYTOR LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Interaction(miRNA-105/PTEN axis) CCK8//qRT-PCR//Western Blot Real-time quantitative PCR (qRT-PCR) disclosed that expression of CYTOR was significantly decreased in colon cancer tissues, compared with that of adjacent normal tissues, while miRNA-105 was significantly increased. Correlation study found that CYTOR was negatively correlated with miR-105. The Starbase database predicted the targeting of miR-105 by CYTOR, and qRT-PCR and dual luciferase reporter gene method were used to verify the targeting relationship of CYTOR and miRNA-105/PTEN axis. Yes The proliferation, migration, and invasion rates of the LoVo cells with highly expressed CYTOR were significantly slower. miR-105 mimic could suppress the decrease in proliferation, migration, and invasion rates of colon cancer cells caused by overexpression of CYTOR. 33936365 CYTOR LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines Interaction(miR-136-5p/MAT2B axis) In Vivo Experiment//RNA Pull-Down//ChIP LncRNA CYTOR was up-regulated in RCC tissues and cell lines, and miR-136-5p was down-regulated in renal carcinoma cell lines and tissues.miR-136-5p was sponged by lncRNA CYTOR, which negatively regulated the development of RCC. MAT2B was a target gene of miR-136-5p. MAT2B protein interacted directly with BAG3 protein to affect the proliferation, invasion and apoptosis of RCC cells. Yes Downregulation of CYTOR inhibited cell proliferation and invasion and promoted apoptosis. miR-136-5p was sponged by lncRNA CYTOR, which negatively regulated the development of RCC. MAT2B was a target gene of miR-136-5p. MAT2B protein interacted directly with BAG3 protein to affect the proliferation, invasion and apoptosis of RCC cells. 35597301 CYTOR LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Regulation[LINC00152/miR-215/CDK13 axis ] qRT-PCR In our current investigation, we observed LINC00152 was obviously upregulated in HCC cells.Therefore, it was revealed that LINC00152 contributed to the progression of HCC by the modulation of miR-215 and CDK13. Yes Subsequently, the in vivo results demonstrated that silence of LINC00152 restrained HCC development via modulating miR-215 to up-regulate CDK13. 31297882 CYTOR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-125b-5p/KIAA1522 axis] CCK8//qRT-PCR//Flow Cytometry//Western Blot As a result, The Cancer Genome Atlas (TCGA) database indicated that expression of CYTOR and KIAA1522 was increased in HCC tissues and high expression of CYTOR and KIAA1522 was related to worse overall survival.In conclusion, CYTOR interference suppressed the proliferation and cell cycle, and promoted the apoptosis of HCC cells by regulating the miR-125b-5p/KIAA1522 axis. Yes The proliferation and cell cycle of HCC cells were suppressed by CYTOR interference while promoted by miR-125b-5p interference and KIAA1522 overexpression. 33318318 CYTOR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-139/PIK3CA] qRT-PCR Herein, we identified a significant up-regulation of LINC00152 in both HCC tissues and cell lines.Taken together, our study revealed a crucial regulatory network of LINC00152/miR-139/PIK3CA axis in the tumorigenesis of HCC, implying that LINC00152 may be a biomarker and novel therapeutic target for further clinical therapy of HCC. Yes Functional studies showed that knockdown of LINC00152 inhibited cell proliferation, migration, and invasion, but promoted cell apoptosis, indicating its oncogenic functions in HCC tumorigenesis. 31954697 CYTOR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-125b/SEMA4C axis) CCK8//qRT-PCR//EdU Staining//Western Blot The results demonstrated that CYTOR was significantly increased in HCC tissues compared with non-tumor tissues and that CYTOR expression was associated with the poor prognosis of patients with HCC. In addition, CYTOR could directly interact with and negatively regulate miR-125b. Furthermore, semaphorin 4C (SEMA4C) was the target of miR-125b and CYTOR regulated SEMA4C expression by modulating miR-125b. The results demonstrated that CYTOR was significantly increased in HCC tissues compared with non-tumor tissues and that CYTOR expression was associated with the poor prognosis of patients with HCC. Yes Furthermore, CYTOR silencing could inhibit the proliferation and promote the apoptosis of HCC cells. CYTOR overexpression had the opposite effects. The results from in vivo xenograft demonstrated that CYTOR knockdown suppressed tumor growth. 34584571 CYTOR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Interaction( LINC00152-miR-143a-3p-KLC2 axis ) qRT-PCR We identified an epigenetic mechanism leading to upregulation of the long intergenic non-coding RNA 152 (LINC00152) expression in human hepatocellular carcinoma (HCC). LINC00152 was confirmed to sponge miR143a-3p in human HCC cell lines, thereby limiting its binding to their respective target genes, like KLC2. KLC2 was identified as a central mediator promoting pro-tumorigenic effects of LINC00152 overexpression in HCC cells. Furthermore, co-expression of LINC00152 and KLC2 was observed in human HCC cohorts and high KLC2 expression was associated with shorter patient survival. The LINC00152-miR-143a-3p-KLC2 axis may represent a therapeutic target in human HCC. Furthermore, co-expression of LINC00152 and KLC2 was observed in human HCC cohorts and high KLC2 expression was associated with shorter patient survival. Yes Functional assays demonstrated that KLC2 promoted cell proliferation, clonogenicity and migration in vitro. 35563834 CYTOR LncRNA Homo sapiens Ovarian Neoplasms Ovarian Cancer tissues Expression[Expression[highly expressed]-expression] CCK8//qRT-PCR//Microarray LINC00152 is Expression[up-expression]regulated in epithelial ovarian cancer tissues comparing to normal tissues. To determine the function of LINC00152 in ovarian cancer, we knocked down the expression of LINC00152 in epithelial ovarian cancer cell line SKOV3 with small interference RNAs (siRNAs). The effects of LIN00152 on the proliferation and cell cycle were determined by comparing the cell viability of SKOV3 cells with LIN00152 knockdown and the control cells with negative siRNA. The cell viability was assessed using Cell Counting Kit-8 (CCK-8) and flow cytometry assay. RNA microarray assay was used again in control and LINC00152 knockdown SKOV3 cells to identify downstream signaling pathways. Yes Knockdown of LINC00152 expression inhibits cell proliferation and induces cell cycle arrest. 31799647 CYTOR LncRNA Homo sapiens Urinary Bladder Neoplasms bladder carcinoma tissues ,cell lines Regulation[Wnt/β-Catenin Signaling Pathway ] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Colony Formation Assay//Transwell Assay We found that Linc00152 was highly expressed in 126 cases of bladder carcinoma tissues (p<0.001) and 4 cell lines (p<0.01), and Linc00152 is more commonly expressed in patients with advanced-stage cancer (p=0.021). This research shows that Linc00152 is highly expressed in patients with bladder cancer and the possible carcinogenic effect of Linc00152 in bladder cancer occurs through activating the Wnt/ß-Catenin signaling pathway, and could be a new biomarker for diagnosis and prevention of this cancer. Yes Knockdown of Linc00152 by using siRNAs in bladder cancer cell lines (T24 and HT-1197) suppressed cell viability and growth by causing cell cycle arrest and apoptosis (p<0.001), as well as inhibiting cell migration and invasion (p<0.001). 31042695 CYTOR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck tumor cell Interaction(LINC00152-USF1/MRPL52 axis) qRT-PCR//Luciferase Report Assay NR_024206.2 was the dominant isoform that accounts for 80% of all transcripts of LINC00152. LINC00152 upregulation was associated with unfavorable survival of patients with OSCC. LINC00152 knockdown significantly impaired OSCC cell growth in vitro and in vivo. RNA FISH assay confirmed nuclear and cytoplasmic distribution of LINC00152. It physically interacted with Upstream Transcription Factor 1 (USF1), a common transcription factor in mammalian cells. USF1 could bind to the promoter region of MRPL52 (Mitochondrial Ribosomal Protein L52) and activate its transcription. LINC00152 could enhance the binding, thereby indirectly elevating MRPL52 expression. USF1 or MRPL52 knockdown slowed the proliferation of OSCC cells and partly canceled LINC00152-mediated growth-promoting effects. LINC00152 upregulation was associated with unfavorable survival of patients with OSCC. Yes LINC00152 knockdown significantly impaired OSCC cell growth in vitro and in vivo. RNA FISH assay confirmed nuclear and cytoplasmic distribution of LINC00152. 34664331 CYTOR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck oral cancer cells Regulation(HNRNPC-mediated ZEB1 stabilization) In Vivo Experiment Here, we report a survival-related long non-coding RNA, CYTOR, which is highly expressed in the lesions of oral cancer patients. We found that CYTOR can promote both migration and invasion in oral cancer cells as well as the epithelial-mesenchymal transition (EMT). RNA-sequencing of CYTOR-knockdown oral cancer cells revealed that CYTOR can regulate mitochondrial respiration and RNA splicing. Mechanistically, we found that nuclear-localized CYTOR interacts with HNRNPC, resulting in stabilization of ZEB1 mRNAs by inhibiting the nondegradative ubiquitination of HNRNPC. By synthesizing CYTOR-targeting small interfering RNAs (siRNAs) encapsulated in Nanoscale Metal Organic Frameworks (NMOFs), we demonstrate the targeted suppression of CYTOR to inhibit invasion and metastasis of oral cancer cells in a nude mouse model. Cumulatively, this study reveals the potential role of the CYTOR-HNRNPC-ZEB1 axis in regulating mitochondrial metabolism and glycolysis of oral cancer cells, and illustrates the effective use of lncRNA targeting in anti-metastatic cancer therapies. Yes RNA-sequencing of CYTOR-knockdown oral cancer cells revealed that CYTOR can regulate mitochondrial respiration and RNA splicing. Mechanistically, we found that nuclear-localized CYTOR interacts with HNRNPC, resulting in stabilization of ZEB1 mRNAs by inhibiting the nondegradative ubiquitination of HNRNPC. 35963855 CYTOR LncRNA Homo sapiens Osteosarcoma cell lines Interaction[sponging miR-193b-3p] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay The current study revealed that LINC00152 is overexpressed in osteosarcoma cells, leading to increased cell proliferation, and decreased G0/G1 cell cycle arrest and apoptosis.These results suggested that LINC00152 binds to miR-193b-3p and reduces its expression level, leading to increased cell proliferation and decreased G0/G1 cell cycle arrest and apoptosis in osteosarcoma cells. Yes The current study revealed that LINC00152 is overexpressed in osteosarcoma cells, leading to increased cell proliferation, and decreased G0/G1 cell cycle arrest and apoptosis. 31579407 CYTOR LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow Interaction[Promoting CDK9 Through miR-193a] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay LINC00152 is determined to be upregulated in the AML samples, and the overexpression of LINC00152 is also authenticated in the advanced French-American-British (FAB) AML patients and closely correlated with the poor outcome of AML patients.The mechanical experiments state that LINC00152 and CDK9 were both targeted by miR-193a with the complementary binding sites at 3'-UTR. Moreover, in the rescue experiments, the enhanced LINC00152 expression could regain the suppression of tumor behavior induced by LINC00152 knockdown. In conclusion, this research reveals the important role of lncRNA LINC00152 in the AML leukemogenesis through targeting miR-193a/CDK9 axis. This finding could indicate the important pathogenesis of ncRNA and the vital roles of epigenetic regulation. Yes LINC00152 is determined to be upregulated in the AML samples, and the overexpression of LINC00152 is also authenticated in the advanced French-American-British (FAB) AML patients and closely correlated with the poor outcome of AML patients. 30707636 CYTOR LncRNA Homo sapiens Leukemia, Myeloid, Acute AML patients Expression(highly expressed) qRT-PCR//Colony Formation Assay Importantly, LINC00152 upregulation was correlated with the expression of 16 genes within a 17-gene LSC biomarker panel, which contributed to the accurate prediction of initial therapy resistance in AML. Upregulation of LINC00152 or PARP1 was associated with poor prognosis in AML patients. Yes Knockdown of LINC00152 markedly increased the drug sensitivity of leukemia cells. Furthermore, LINC00152 expression was found to be correlated with poly (ADP-ribose) polymerase 1 (PARP1) expression in AML, whereas LINC00152 knockdown significantly decreased the expression of PARP1. 34295821 CYTOR LncRNA Homo sapiens Glioma Regulation[miR-612/AKT2/NF-κB pathway] qRT-PCR//IF//Western Blot LINC00152 acted as a tumor oncogene with prognostic value for patients with glioblastoma through LINC00152/miR-612/AKT2/NF-κB axis. LINC00152 was closely associated with glioma WHO classification and poor prognosis, and indicated a poor prognosis in glioblastoma patients. Yes Tumor growth and invasion were suppressed both in vitro and vivo after LINC00152 was blocked. 30043319 CYTOR LncRNA Homo sapiens Glioma glioma tissues and cell lines regulation[PI3K/AKT signaling pathway] qRT-PCR//MTT//RIP//Transwell Assay The levels of LINC00152 and CD164 were obviously increased while miR-613 was especially decreased in glioma tissues and cell lines.Low-expression of LINC00152 modified cell proliferation, apoptosis migration and invasion through LINC00152/miR-613/CD164 axis via PI3K/AKT signaling pathway in glioma, thus providing new therapeutic target in the clinical treatment of glioma. Yes The downregulation of LINC00152 and CD164, as well as the upregulation of miR-613 induced cell apoptosis, repressed viability, migration, and invasion. 32726126 CYTOR LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction[binding to miR-613] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that CYTOR expression was elevated both in NPC tissues and cells. Mechanically, we found that the subcellular localization of CYTOR mostly occurred in the cell cytoplasm. Luciferase reporter and RIP assays confirmed that CYTOR functioned as the molecular sponge of miR-613. Subsequent experiments confirmed that ANXA2 was directly targeted by miR-613. Yes Gain- and loss-of-function studies further confirmed that CYTOR induced the upregulation of ANXA2 by competitively binding to miR-613, thus leading to NPC metastasis. 31859457 CYTOR LncRNA Homo sapiens Glioblastoma U87-MG and LN229 glioblastoma cells Regulation FISH//qRT-PCR//migration assay//Cell Viability Assay//Cell Proliferation Assay//Cell Cycle Assay//Invasion Assay SiRNA-based knockdown of LINC00152 enhanced malignant tumor behaviors including proliferation, cell cycle entry, migration, and invasion, contradicting previous studies using U87-MG and LN229 glioblastoma cells. Furthermore, LINC00152 knockdown had no influence on survival of A172 glioblastoma cells. Yes SiRNA-based knockdown of LINC00152 enhanced malignant tumor behaviors including proliferation, cell cycle entry, migration, and invasion, contradicting previous studies using U87-MG and LN229 glioblastoma cells. Furthermore, LINC00152 knockdown had no influence on survival of A172 glioblastoma cells. 34531451 CYTOR LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues regulation[miR-205-5p/CDK6 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay The expression of LncRNA CYTOR was significantly elevated in PC. CYTOR can promote PC progression by modulating the miR-205-5p/CDK6 axis, which may be a potential therapeutic target for PC. Yes Knockdown of CYTOR significantly inhibited cell proliferation and migration of PC cells. In vivo animal studies showed that CYTOR promoted tumor growth. 32732173 CYTOR LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues interaction[miRNA-193b-3p] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay The present study revealed that long intergenic non-coding RNA 00152 (LINC00152) expression was significantly increased in human TSCC tissues compared with in tissues from matched controls using RT-qPCR. Overall, the results of the present study suggested that increased LINC00152 expression in TSCC tissues may act as a sponge of miR-193b-3p to promote cancer progression in vitro. Yes In TSCC cell lines, CAL-27 and SCC-9, LINC00152 was revealed to promote TSCC cell proliferation, enhance cell cycle progression and inhibit cell apoptosis. 32194700 CYTOR LncRNA Homo sapiens Thyroid Cancer, Papillary PTC cells Interaction(E2F1) CCK8//qRT-PCR//Colony Formation Assay//Western Blot Both LINC00152 and E2F1 were highly expressed in PTC cells.In addition, E2F1 induced LINC00152 overexpression, which accelerated cell proliferation, migration, and invasion by activating the PI3K/AKT axis, whereas the administration of LY294002, the inhibitor of PI3K, led to reversal of the same. Yes Knockdown of LINC00152 led to reduced cell activity, while LINC00152 overexpression brought about the opposing trends. Likewise, E2F1 knockdown quenched cell proliferation, migration, and invasion. However, the combination of E2F1 knockdown and LINC00152 overexpression resulted in augmented cell growth. Finally, xenograft transplantation validated that E2F1 inhibition could suppress LY294002, thereby discouraging tumor growth. 35592867 CYTOR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[YAP1/LINC00152/FSCN1 Signaling Axis] RNA Pull-Down//CCK8//qRT-PCR//RIP//Luciferase Report Assay//ChIP "Here, a YAP1 target gene, long intergenic noncoding RNA 00152 (LINC00152), which is highly expressed in colorectal cancer (CRC), is identified. This finding provides a new regulatory model of the ""YAP1-lncRNA"" in CRC, which gives rise to a new perspective, ""YAP1/LINC00152/miR-632-miR-185-3p/FSCN1,"" to explore the cancer-promoting mechanism of YAP1 involved in CRC." Yes The oncogenic functions of LINC00152 in CRC are demonstrated by a panel of in vitro and in vivo experiments. 32042551 CRNDE LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Expression[highly expressed] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Transwell Assay CRNDE expression was increased in OSCC tissues and cell lines compared with that in normal tissues and cell lines. Compared with the control group, the si-CRNDE group displayed a reduction in the expression of CRNDE, in the proliferation, migration and invasion of cells, in the protein expression of N-cadherin, vimentin and Snail, and in the expression of proteins in the Wnt/β-catenin pathway. Yes In conclusion, silencing CRNDE may inhibit EMT, thus decreasing the migration and invasion of human OSCC cells by repressing the activation of the Wnt/β-catenin signaling pathway, thereby restricting cell growth and promoting cell apoptosis. 30867767 CYTOR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Regulation[ miR-107/Rab10 Axis ] CCK8//qRT-PCR//Transwell Assay//Western Blot LINC00152, Rab10 was significantly upregulated, and miR-107 was strikingly down-regulated in ESCC tissues and cell lines (TE-1 and KYSE30).In this study, we found that LINC00152 modulated Rab10 to promote cell proliferation, migration and invasion in ESCC by sponging miR-107. Yes LINC00152 depletion decreased cell viability and abilities of migration and invasion by regulating miR-107 in vitro and blocked xenograft tumor growth in vivo. 31802892 DANCR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[inhibiting p21] qRT-PCR DANCR expression level was increased in human NSCLC. DANCR knockdown inhibited EZH-2-mediated epigenetic silencing of p21 promoter and increased p21 expression. Moreover, DANCR knockdown inhibited NSCLC cell proliferation, migration, and invasion in a p21-dependent manner. Yes The knockdown of DANCR inhibited NSCLC cell proliferation by inducing cell apoptosis and cell cycle arrest. In addition, DANCR knockdown suppressed NSCLC cell migration and invasion via inhibition of epithelial-mesenchymal transition (EMT).On the contrary, DANCR overexpression had the opposite effects. 30613152 DANCR LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cells regulation[ miR-345-5p/Twist1 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay We found that the expression of DANCR was significantly induced in CCA tissues and cells.In this study, we verified that LncRNA DANCR affected cell proliferation, migration, invasion, angiogenesis, epithelial-mesenchymal transition (EMT) and induced apoptosis through modulating miR-345-5p/Twist1 axis in Cholangiocarcinoma. Yes Inhibition of DANCR remarkably suppressed CCA cell proliferation, migration, invasion, EMT and angiogenesis as well as induced cell apoptosis in vitro and in vivo. 32196584 DANCR LncRNA Homo sapiens Prostatic Neoplasms PC patients' serum and cell lines Interaction(miR-214-5p) RNA Pull-Down//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay DANCR was up-regulated in PC patients' serum and cell lines, while miR-214-5p was opposite, showing negative correlation. We found that DANCR high levels or miR-214-5p low levels were related to PC patients' poor prognosis. DANCR regulates miR-214-5p in a targeted manner, and DANCR over-expression can reduce the cancer inhibitory effect of miR-214-5p on PC cells. Besides, DANCR was significantly correlated with PSA, Gleason score and T stage in PC patients. The area under the curve (AUC) of DANCR and miR-214-5p for diagnosing PC was not less than 0.850, while the AUC for predicting poor prognosis was more than 0.800. Cox analysis results also revealed that the two might be prognostic indicators of PC patients. Yes Up-regulating DANCR or down-regulating miR-214-5p could promote PC cells' malignant proliferation and migration, prevent apoptosis, and activate TGF-β signaling pathway, while reverse treatment of DANCR or miR-214-5p can reverse the above results. 34017385 DANCR LncRNA Homo sapiens tongue squamous cell carcinoma Regulation[miR-135a-5p/KLF8 axis ] Western Blot//Wound Healing Assay//qRT-PCR//IF//MTT//Luciferase Report Assay//Transwell Assay These findings, for the first time, suggest that DANCR plays an oncogenic role in TSCC progression via targeting miR-135a-5p/KLF8 axis, which provides a promising biomarker and treatment approach for preventing TSCC. Yes DANCR knockdown reduced the viability and inhibited the migration and invasion of TSCC cells in vitro, while ectopic expression of DANCR induced opposite effects. 31827393 DANCR LncRNA Homo sapiens cervical squamous cell carcinoma Interaction[HIF‑1α] CCK8//qRT-PCR//Western Blot It was observed that ANCR was downregulated in human papillomavirus (HPV)‑negative patients with CSCC compared with in normal female cases and HPV‑positive patients with CSCC in cervical tissues and in the serum, and the downregulation of ANCR effectively distinguished HPV‑negative patients with CSCC from healthy controls. ANCR overexpression inhibited HIF‑1α expression in HPV‑negative CSCC cells, while HIF‑1α overexpression exhibited no significant effect on ANCR expression. It was therefore concluded that ANCR may inhibit the growth of HPV‑negative cervical squamous cell carcinoma under hypoxic conditions by downregulating HIF‑1α. Yes ANCR overexpression inhibited the proliferation of HPV‑negative CSCC cells under hypoxic conditions, whilst HIF‑1α overexpression reversed this effect. 31746351 DANCR LncRNA Homo sapiens Pre-Eclampsia placental tissues of patients Interaction(microRNA-214-5p/ PI3K/AKT) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Cell Cycle Assay//Transwell Assay Studies have shown that lncRNA DANCR is down-regulated in placental tissues of patients with preeclampsia (PE). Further, the targeted interaction between lncRNA DANCR and miR-214-5p was confirmed by the dual-luciferase reporter gene assay. In addition, the expression of PI3K/AKT signaling pathway-related proteins was analyzed by Western blot. Overexpression of lncRNA DANCR can increase the phosphorylation of PI3K/AKT protein and activate this signaling pathway. Yes The results showed that overexpression of lncRNA DANCR significantly increased the proliferation, invasion, migration, and EMT process of trophoblast cells. Interfering with lncRNA DANCR showed the opposite result. 34652251 DANCR LncRNA Homo sapiens Carcinoma, Basal Cell BCC tissues Interaction(PTCH) In Vivo Experiment//RNA Pull-Down//cell invasion assay//Western Blot//Wound Healing Assay//Tunel//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay ANCR and Hedgehog pathway were more highly expressed in BCC tissues than in adjacent normal tissues. An RNA pull-down assay further revealed that ANCR is specifically bound to PTCH. In vivo experiments also showed that ANCR overexpression significantly increased tumor growth and decreased apoptosis, which was reversed by cyclopamine, a specific inhibitor of the Hedgehog signaling pathway. Yes ANCR overexpression substantially promoted BCC cell proliferation, invasion, and migration, inhibited apoptosis, and up-regulated BCL2 and decreased the expression of BAX and Cleaved-caspase3 proteins. Additionally, the upregulation of N-cadherin, vimentin, β-catenin, PTCH, GLI1, and SMO expression, and downregulation of E-cadherin expression were observed after ANCR overexpression. Moreover, ANCR knockdown had the opposite effects. 35642174 DACH1 LncRNA Homo sapiens Pulmonary Fibrosis lungs of IPF patients, mouse model of lung fibrosis Interaction(SRSF1/CTNNB1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//FISH//IHC//EdU Staining//IF Here we report that lncRNA DACH1 (dachshund homolog 1) is downregulated in the lungs of IPF patients and in an experimental mouse model of lung fibrosis. Mechanistically, LncDACH1 binding to the serine/arginine-rich splicing factor 1 (SRSF1) protein decreases its activity and inhibits the accumulation of Ctnnb1. Enhanced expression of SRSF1 blocked the anti-fibrotic effect of LncDACH1 in lung fibroblasts. Furthermore, loss of LncDACH1 promoted proliferation, differentiation, and extracellular matrix (ECM) deposition in mouse lung fibroblasts, whereas such effects were abolished by silencing of Ctnnb1. In addition, a conserved fragment of LncDACH1 alleviated hyperproliferation, ECM deposition and differentiation of MRC-5 cells driven by TGF-β1. Yes LncDACH1 knockout mice develop spontaneous pulmonary fibrosis, whereas overexpression of LncDACH1 attenuated TGF-β1-induced aberrant activation, collagen deposition and differentiation of mouse lung fibroblasts. Similarly, forced expression of LncDACH1 not only prevented bleomycin (BLM)-induced lung fibrosis, but also reversed established lung fibrosis in a BLM model. 36176913 cZNF532 CircRNA Homo sapiens Diabetic Retinopathy pericytes under diabetic stress, in the retinal vessels of a diabetic murine model, and in the vitreous humor of diabetic patients Expression[highly expressed] Microarray Yes cZNF532 silencing reduced the viability, proliferation, and differentiation of pericytes and suppressed the recruitment of pericytes toward endothelial cells in vitro. 32343678 CYTOR LncRNA Homo sapiens Stomach Neoplasms GC tissues ,cell lines Regulation[microRNA-193b-3p/ETS1 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Linc00152 expression was notably upregulated in GC tissues and cells. Linc00152 upregulation inhibited miR-193b-3p expression by direct interaction and abolished miR-193b-3p-mediated anti-proliferation, anti-migration and anti-invasion effects in GC cells. ETS1 was a target of miR-193b-3p and linc00152 could promote ETS1 expression by downregulating miR-193b-3p. Yes The proliferative, migratory and invasive abilities of GC cells were weakened by linc00152 depletion, miR-193b-3p overexpression or ETS1 knockdown. 30404587 CYTOR LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines,blood Interaction[bind with Bcl-2] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Transwell Assay The results revealed that LINC00152 was overexpressed in tissues, serum, and PBMCs of patients with gastric cancer. LINC00152 could bind with Bcl-2 directly to induce the activation of cell cycle signaling, and this may be a potential target for the therapy of gastric cancer in the future. Yes Moreover, LINC00152 could promote the migration and invasive abilities and suppress the apoptosis, of gastric cancer cells through regulating the Bcl-2 protein family. 30304559 CYTOR LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(miR-138/SIRT2 axis) Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Transwell Assay We found that LINC00152, a newly identified lncRNA, was significantly upregulated in GC tissues and affected clinicopathological characteristics in GC patients. Further bioinformatic analysis indicated that LINC00152 competitively bound with miR-138 and regulated the expression of miR-138. Moreover, SIRT2 was further proved to be a downstream target of miR-138. We found that LINC00152, a newly identified lncRNA, was significantly upregulated in GC tissues and affected clinicopathological characteristics in GC patients. Yes Furthermore, we observed that LINC00152 knockdown can significantly reduce cell proliferation and promote apoptosis in human gastric cancer cells. 34697541 CYTOR LncRNA Homo sapiens Stomach Neoplasms GC patients Interaction( EZH2 /CXCL9, 10/CXCR3 axis) CCK8//qRT-PCR//Western Blot//ChIP In this study, we found increased LINC00152 expression levels are positively associated with the poor prognosis of GC patients and negatively associated with the CD8 levels. ChIP assay verified that LINC00152 recruits EZH2 to the promoters of CXCL9 and CXCL10, thus the silencing of LINC00152 promoted the production of CXCL9 and CXCL10. In this study, we found increased LINC00152 expression levels are positively associated with the poor prognosis of GC patients and negatively associated with the CD8 levels. Yes Knockdown of LINC00152 suppressed tumor cells growth in vivo and in vitro, increased tumor-infiltrating CD8+ T cells numbers and promoted the expression of CXCL9, CXCL10 and C-X-C Motif Chemokine Receptor 3 (CXCR3) in xenograft tumors. 33709190 CYTOR LncRNA Homo sapiens Stomach Neoplasms cancer samples and cells Interaction(miR-103/RAB10) qRT-PCR We found that CYTOR expression was increased in metastatic gastric cancer biopsies compared with that in primary samples. CYTOR expression was significantly positively correlated with the invasiveness, lymph node metastasis, and advanced stages of gastric cancer. Furthermore, CYTOR sponged miR-103 and diminished miR-103 expression, thus rescuing oncogene RAB10 expression. We found that CYTOR expression was increased in metastatic gastric cancer biopsies compared with that in primary samples. CYTOR expression was significantly positively correlated with the invasiveness, lymph node metastasis, and advanced stages of gastric cancer. Yes In addition, downregulation of CYTOR expression hampered cell proliferation and migration but induced cell apoptosis.Knockdown of CYTOR suppressed tumor growth in human BGC823 mouse models. 34110382 CYTOR LncRNA Homo sapiens Stomach Neoplasms GC cells Interaction(HMGA1 ) CCK8//qRT-PCR//Cell Cycle Assay//Western Blot Treating GC cell lines with LINC00152 siRNAs downregulated the expression of HMGA1. The cell cycle was arrested in the S phase following a reduction in LINC00152 or HMGA1 expression, whereas the expression of the cell cycle inhibitor P27 increased. Yes In this study, we showed that acting as a ceRNA of HMGA1, LINC00152 has the same function as HMGA1, considering that it could control the cell cycle and promote GC cell proliferation. 35014092 CYTOR LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Western Blot//Transwell Assay The results showed that Linc00152 was highly expressed in the breast cancer tissues compared to their adjacent normal tissues, and Linc00152 was also up-regulated in the breast cancer cell lines compared to normal cell lines. Yes Knock-down of Linc00152 by using siRNAs in breast cancer cell lines (MDA-MB-231 and MCF-7) significantly suppressed cell viability, cell growth, cell invasion and migration as measured by the CCK-8, colony formation, transwell invasion, and migration assays. 29863253 CYTOR LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(KLF5 ) RNA Pull-Down//Western Blot//ISH//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay Our study found that LINC00152 is significantly upregulated in breast cancer, and that it acts as an indicator of poor survival prognosis. Mechanistic analyses demonstrated that LINC00152 directly binds to KLF5 protein and increases KLF5 stability. Moreover, LINC00152 is also a KLF5-responsive lncRNA, and KLF5 activates LINC00152 transcription by directly binding to its promoter. Our study found that LINC00152 is significantly upregulated in breast cancer, and that it acts as an indicator of poor survival prognosis. Yes Further studies revealed that LINC00152 knockdown suppresses cell proliferation and tumorigenicity in vitro and in vivo. 33842324 CYTOR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissue and peripheral blood Expression[highly expressed] qRT-PCR In NSCLC, the high expression of LINC00152 in tumor tissue and peripheral blood samples has been shown to be associated with worse prognoses of NSCLC patients. In NSCLC, the high expression of LINC00152 in tumor tissue and peripheral blood samples has been shown to be associated with worse prognoses of NSCLC patients. Yes Overexpression of LINC00152 has been confirmed to promote the proliferation, invasion, and migration of NSCLC cells in vitro, as well as increase tumor growth in vivo. 32133796 CYTOR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tumor tissues Regulation[miR-153-3p/FYN axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay Our results revealed that LINC00152 expression was up-regulated in ESCC, and correlated with advanced TNM stage, lymph node metastasis, and poor prognosis of ESCC patients.Taken together, LINC00152 contributed to ESCC progression by down-regulating miR-153-3p and promoting FYN expression, uncovering a novel LINC00152/miR-153-3p/FYN regulatory pathway in ESCC. Our results revealed that LINC00152 expression was up-regulated in ESCC, and correlated with advanced TNM stage, lymph node metastasis, and poor prognosis of ESCC patients. Yes Functionally, LINC00152 knockdown suppressed proliferation, decreased colony forming ability, and induced apoptosis in ESCC cells. 30784933 CYTOR LncRNA Homo sapiens Cardiomegaly Regulation[miR-155-mediated IKKi signaling] Transfection//Immunoblotting//qRT-PCR//RIP//Luciferase Report Assay//H&E Staining In the present study, microarray analysis results from GEO database were analyzed, and upregulated lncRNAs in cardiac hypertrophy were identified. Taken together, CYTOR might play a protective role in cardiac hypertrophy through miR-155 and downstream IKKi and NF-κB signaling, most possibly through serving as a ceRNA for miR-155 to counteract miR-155-mediated repression of IKBKE. Yes CYTOR knockdown significantly enhanced the inducible effect of AB operation on mice myocardial hypertrophy and Angiotensin II on cardiomyocyte hypertrophy. 30794866 CYTOR LncRNA Homo sapiens Laryngeal Neoplasms LSCC tissues interaction[Sponging MiR-613] qRT-PCR//Luciferase Report Assay LINC00152 levels in LSCC tissues were significantly higher than those in adjacent normal tissue, and patients with lymph node metastasis or an advanced clinical stage displayed higher LINC00152 expression.LINC00152 exerts an oncogenic effect on the tumorigenesis of LSCC by sponging miR-613 and may serve as a potential target for treating LSCC. LINC00152 levels in LSCC tissues were significantly higher than those in adjacent normal tissue, and patients with lymph node metastasis or an advanced clinical stage displayed higher LINC00152 expression. Yes Moreover, siRNA-mediated LINC00152 knockdown significantly inhibited the proliferation, migration and invasion of LSCC cells and induced apoptosis in those cells. 32266320 CYTOR LncRNA Homo sapiens capillary hemangioma infantile skin hemangioma tissues Interaction[miR-139-5p] Western Blot//ISH//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Linc00152 was overexpressed in the proliferating-phase hemangioma tissues when compared with that in involuting-phase. ubsequent analysis revealed that linc00152 bound with miR-139-5p and linc00152 expression was inversely correlated with the level of miR-139-5p in IH. Same effects of miR-139-5p transfection on HemECs cells were observed as downregulation of linc00152. Moreover, tumor protein D52 (TPD52) was confirmed to be the target of miR-139-5p. Besides, the anti-tumor effect of linc00152 silence on hemangioma cell was reversed by rexpression of TPD52. Yes Downregulation of linc00152 strikingly suppressed the cell viability, migration and invasion of hemangioma cells. Furthermore, silence of linc00152 repressed the growth and lung metastasis of hemangioma cell in vivo. 31542613 CYTOR LncRNA Homo sapiens capillary hemangioma IH tissues Regulation[Akt/mTOR and Notch1 pathways ] CCK8//qRT-PCR//Western Blot The results demonstrated Linc00152 was up-regulated in clinical IH tissues and HemECs.Knockdown of Linc00152 suppressed HemECs proliferation and induced apoptosis via inhibiting Akt/mTOR and Notch1 signaling pathways. Yes Knockdown of Linc00152 in HemECs suppressed the activation of Akt/mTOR and Notch1 signaling pathways and caused reduction in cell proliferation and Ki67 expression in HemECs. Besides, Linc00152 knockdown resulted in a significant increase in apoptotic rate, caspase-3/7 activity, and Bax expression level, as well as a decrease in Bcl-2 expression level. 30851338 CTBP1-DT LncRNA Homo sapiens Ovarian Neoplasms a cohort of HGSOC tissues Interaction(miR-188-5p/MAP3K3 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis//ChIP Based on public databases and bioinformatics analyses, the overexpression of lncRNA CTBP1-DT in HGSOC tissues was detected and validated in a cohort of HGSOC tissues. Mechanistically, lncRNA CTBP1-DT could competitively bind to miR-188-5p to protect MAP3K3 from degradation. Moreover, our results revealed that ETV5 could specifically interact with the promoter of lncRNA CTBP1-DT and activate its transcription. High expression of lncRNA CTBP1-DT was associated with poor prognosis and was an independent risk factor for survival. Yes Overexpression of lncRNA CTBP1-DT promoted malignant biological behaviour of HGSOC cells, whereas its depletion induced growth arrest of HGSOC cells by vitro and in vivo assays. 34887384 CTBP1-AS2 LncRNA Mus musculus Cardiomyocyte Hypertrophy heart tissues Regulation[ regulating TLR4] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//ChIP We revealed the up-regulation of CTBP1-AS2 and TLR4 in cardiomyocyte hypertrophy models. In conclusion, our study uncovered CTBP1-AS2 as a novel regulator of cardiomyocyte hypertrophy through regulating TLR4, providing a new potential treatment target for cardiomyocyte hypertrophy. Yes Loss-of-function assays confirmed that inhibiting CTBP1-AS2 attenuated the Ang II-induced cardiomyocyte hypertrophy. 31220774 CTBP1-AS LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines Interaction[microRNA-940] Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The results showed that LncRNA CTBP1-AS was aberrantly overexpressed in breast cancer tissues and breast cancer cells compared to the control group.Bioinformatics analysis and dual-luciferase reporter gene system results validated that microRNA-940 was the downstream target of LncRNA CTBP1-AS. Interestingly, overexpressed microRNA-940 abrogated the effects of LncRNA CTBP1-AS on cell proliferation, apoptosis, and invasion. In conclusion, overexpressed LncRNA CTBP1- AS promoted breast cancer cell proliferation, invasion as well as migration, inhibited cell apoptosis and accelerated breast cancer development by sponging microRNA-940. Moreover, the expression levels of LncRNA CTBP1-AS were positively related with tumor size, histological grade and the expression levels of Ki-67 and Her2. Yes Of note, overexpressed LncRNA CTBP1-AS promoted breast cancer cell proliferation and invasion as well as migration, and decreased cell apoptosis ratio. 31165609 CTB-193M12.5 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell line Regulation(WNT10B/Wnt/β-catenin signaling) qRT-PCR CTB-193M12.5 was upregulated in HCC and its high expression was correlated with alpha fetoprotein, large tumor size, aggressive clinical characteristics, and poor survival. Mechanistic investigation demonstrated that CTB-193M12.5 was mainly distributed in nucleus. Histone methyltransferase NSD1 was identified as a CTB-193M12.5 interactor. CTB-193M12.5 bound and recruited NSD1 to the promoter of WNT10B, leading to an increase in di-methylation of histone H3 at lysine 36 (H3K36me2) and the reduction of tri-methylation of histone H3 at lysine 27 (H3K27me3) at WNT10B promoter. Therefore, CTB-193M12.5 epigenetically activated WNT10B transcription. Through upregulating WNT10B, CTB-193M12.5 further activated Wnt/β-catenin signaling. Functional rescue experiments demonstrated that overexpression of WNT10B reversed the tumor suppressive roles of CTB-193M12.5 knockdown, while Wnt/β-catenin signaling inhibitor ICG-001 abolished the oncogenic roles of CTB-193M12.5 overexpression. CTB-193M12.5 was upregulated in HCC and its high expression was correlated with alpha fetoprotein, large tumor size, aggressive clinical characteristics, and poor survival. Yes Functional experiments showed that CTB-193M12.5 enhanced HCC cellular proliferation, suppressed HCC cellular apoptosis, and promoted HCC cellular migration and invasion. CTB-193M12.5 knockdown exerted opposite effects in HCC. 35698644 CTA-217C2.1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[lower expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 CRYBG3 LncRNA Homo sapiens Lung Neoplasms plasma of NSCLC patients Interaction(eEF1A1/MDM2/MTBP Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Co-IP//qRT-PCR//IP//Transwell Assay Exogenously overexpressed LNC CRYBG3 increased the metastatic ability and the protein expression level of the metastasis-associated proteins Snail and Vimentin in low metastatic lung cancer HCC827 cell line. In conclusion, the LNC CRYBG3/eEF1A1/MDM2/MTBP axis is a novel signaling pathway regulating tumor metastasis and may be a potential therapeutic target for NSCLC treatment. Yes In addition, LNC CRYBG3 contributed to HCC827 cell metastasis in vivo. 33809929 CRNDE LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[miR-641/CDK6 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay CRNDE level was upregulated in NSCLC. CRNDE promoted proliferation and inhibited apoptosis of NSCLC cells at least in part by regulating the miR-641/CDK6 axis, suggesting that CRNDE is a potential therapeutic target for NSCLC treatment. Yes CRNDE level was upregulated in NSCLC, and its knockdown suppressed NSCLC cells proliferation and enhanced apoptosis, whereas miR-641 antagonized the regulatory effect of CRNDE knockdown by directly binding to CRNDE. 30982057 CRNDE LncRNA Homo sapiens Colorectal Neoplasms Th17 cell Regulation RNA Pull-Down//Flow Cytometry//qRT-PCR//FISH//ELISA CRC exosomes contained abundant CRNDE-h and transmitted them to CD4+ T cells to increase the Th17 cell proportion, RORγt expression, and IL-17 promoter activity. The underlying mechanism is that, CRNDE-h bound to the PPXY motif of RORγt and impeded the ubiquitination and degradation of RORγt by inhibiting its binding with the E3 ubiquitin ligase Itch. Yes CRC exosomes contained abundant CRNDE-h and transmitted them to CD4+ T cells to increase the Th17 cell proportion, RORγt expression, and IL-17 promoter activity. The in vivo experiments confirmed that the targeted silence of CRNDE-h in CD4+ T cells attenuated the CRC tumor growth in mice. 33495437 CRNDE LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues regulation[miR-136-5p] qRT-PCR//Western Blot CRNDE was overexpressed and miR-136-5p was low-expressed in RCC. CRNDE can mediate miR-136-5p, promote the development of EMT and RCC cells, showing the potential to serve as a novel biomarker and therapeutic target in RCC treatment. Yes Upregulation of CRNDE could promote the viability, migration, invasion of RCC, while downregulation of CRNDE produced the opposite effects. 32808846 CRNDE LncRNA Homo sapiens Osteoarthritis bone marrow mesenchymal stem cells Regulation(SIRT1/SOX9) RNA Pull-Down//Western Blot//RIP//qRT-PCR//Luciferase Report Assay//Cell Viability Assay With the prolongation of induction time, the expression of lncRNA-CRNDE, SIRT1, cartilage marker genes Aggrecan and collagen 2 (α1) in BMSC osteogenic differentiation was gradually increased. lncRNA-CRNDE regulates BMSC chondrogenic differentiation to promote cartilage repair in osteoarthritis through SIRT1/SOX9. Yes With the prolongation of induction time, the expression of lncRNA-CRNDE, SIRT1, cartilage marker genes Aggrecan and collagen 2 (α1) in BMSC osteogenic differentiation was gradually increased. 33479807 CRNDE LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[modulating miR-337-3p] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Western Blot LncRNA CRNDE was overexpressed in tumor tissues of patients with HCC.Mechanistic investigations demonstrated that lncRNA CRNDE interacted with miR-337-3p and decreased its expression, thereby increasing the protein expression of miR-337-3p's target, SIX1. In addition, in vivo experiments using a xenograft tumor mouse model revealed that lncRNA CRNDE served as an oncogene, partly through sponging miR-337-3p and upregulating SIX1 in HCC. Yes LncRNA CRNDE downregulation significantly suppressed cell proliferation and migration. 31099050 CRNDE LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[Wnt/β-catenin signaling pathway ] Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//IHC//Invasion Assay CRNDE was significantly upregulated in tumor tissues compared with adjacent normal tissues.Thus, CRNDE could modulate EMT of HCC cells and knockdown of CRNDE impaired the mesenchymal properties. CRNDE increased invasion of HCC cells might be through activating the Wnt/β-catenin signaling pathway. Yes In vitro, we revealed that knockdown of CRNDE inhibited cell proliferation, migration, and cell invasion capacities in HCC. Animal studies indicated that CRNDE knockdown represses both growth and metastasis of HCC tumors in vivo. 30430650 CRNDE LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-33a-5p/CDK6 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay CRNDE and CDK6 were upregulated in HCC tissues and cells, while miR-33a-5p was downregulated. Overall, the present work indicated that CRNDE plays an oncogenic function in HCC through regulating the miR-33a-5p/CDK6 axis, revealing a potential therapeutic target in HCC. Yes Inhibition of CRNDE suppressed the invasion, migration, and proliferation of HCC cells and enhanced apoptosis by modulating proteins associated with mitochondrial apoptosis (caspase 3, Bax, cytochrome-c, Bcl-2), which were the same as the function of miR-33a-5p overexpression. 32621257 CRNDE LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and HCC tissues interaction[miR-539-5p] RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay lncRNA CRNDE was highly expressed in HCC cells and HCC tissues compared with normal cells and the corresponding adjacent normal tissues.lncRNA CRNDE promotes the expression of POU2F1 by adsorbing miR-539-5p, thus promoting the progression of HCC. Yes lncRNA CRNDE promoted the cell viability, migration and invasion of HCC cells, while inhibited the apoptosis and promoted the EMT process of HCC cells. 32252678 CRNDE LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR‑29c‑3p/NASP ) Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//IHC//Bioinformatics Analysis//Transwell Assay CRNDE was found to be upregulated in HCC tissues and cells, and to be positively associated with the poor prognosis of patients with HCC. Bioinformatics and RT‑qPCR analysis indicated miR‑29c‑3p as a potential target of CRNDE. In line with previous reports, as a tumor suppressor, downregulated expression of miR‑29c‑3p was observed in HCC. In addition, the present study revealed that miR‑29c‑3p directly targeted NASP. CRNDE was found to be upregulated in HCC tissues and cells, and to be positively associated with the poor prognosis of patients with HCC. Yes Furthermore, CRNDE?knockdown suppressed cell proliferation, migration and invasion abilities. 34633056 CRNDE LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-136-5p/ILF2 ) qRT-PCR//Western Blot In addition, we showed that long noncoding RNA colorectal neoplasia differentially expressed-h (lncRNA CRNDE-h) transcript expression was significantly up-regulated in HCC, and a miR-136-5p binding site was newly found in the lncRNA CRNDE-h transcript sequence using IntaRNA tool. In terms of mechanism, highly-expressed lncRNA CRNDE-h transcript can sponge miR-136-5p, thereby preventing it from interacting with target ILF2 mRNA while promoting the proliferation of HCC cells. Yes In terms of mechanism, highly-expressed lncRNA CRNDE-h transcript can sponge miR-136-5p, thereby preventing it from interacting with target ILF2 mRNA while promoting the proliferation of HCC cells. 34153299 CRNDE LncRNA Homo sapiens Carcinoma, Hepatocellular clinical specimens of HCC Interaction(CRNDE/p300/YY1 axis) qRT-PCR In this study, we showed that CRNDE expression is significantly positively correlated with that of epidermal growth factor receptor (EGFR) in clinical specimens of HCC and induces proliferation and sorafenib resistance of HCC via EGFR-mediated signaling. Mechanistically, CRNDE stabilized the p300/YY1 complex at the EGFR promoter and simultaneously enhanced histone H3K9 and H3K27 acetylation, which serve as markers of relaxed chromatin. EGFR was positively upregulated by the epigenetic complex, p300/YY1, in a manner dependent on CRNDE expression, leading to enhanced tumor cell proliferation and sorafenib resistance. Furthermore, C646, a p300 inhibitor, suppressed EGFR transcriptional activity by decreasing chromatin relaxation and YY1 binding, which effectively reduced proliferation/sorafenib resistance and prolonged overall survival. Yes In this study, we showed that CRNDE expression is significantly positively correlated with that of epidermal growth factor receptor (EGFR) in clinical specimens of HCC and induces proliferation and sorafenib resistance of HCC via EGFR-mediated signaling. 35999564 CRNDE LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer cells Interaction( miR-423-5p/FSCN1 axis) qRT-PCR//Western Blot CRNDE and FSCN1 were upregulated in ovarian cancer cells (SKOV3, CAOV-3, IGROV1, A2780 and C13K), while miR-423-5p was downregulated. In addition, CRNDE could sponge miR-423-5p, and FSCN1 was confirmed to be the direct target of miR-423-5p. Furthermore, CRNDE knockdown-induced inhibition of FSCN1 was notably reversed by miR-423-5p downregulation. Knockdown of CRNDE inhibited cell proliferation, migration and invasion of ovarian cancer via miR-423-5p/FSCN1 axis. Thus, CRNDE may serve a new target for ovarian cancer. Yes Moreover, silencing of FSCN1/CRNDE significantly decreased proliferation, migration and invasion of ovarian cancer cells (SKOV3 and CI3K) via suppressing MMP-2 and MMP-9. 35166986 CRNDE LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cells Expression [highly expressed] qRT-PCR//Cell Apoptosis Assay//Migration Assay In this work, we have presented evidence that CRNDE was significantly increased in bladder cancer, and overexpressed expression of CRNDE was positively related with advanced TNM stage of bladder cancer patients. In this work, we have presented evidence that CRNDE was significantly increased in bladder cancer, and overexpressed expression of CRNDE was positively related with advanced TNM stage of bladder cancer patients. Yes In addition, in vitro experiments showed that CRNDE strengthened cell migration/proliferation and inhibited cell apoptosis in bladder cancer. 29710461 CTBP1-DT LncRNA Homo sapiens Pancreatic Carcinoma pancreatic carcinoma tissues and cell line Interaction(miR-141-3p and USP22 ) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay It was demonstrated that CTBP1-AS2 expression was markedly increased in pancreatic carcinoma tissues and cell lines. In terms of mechanism, it was found that CTBP1‑AS2 adsorbed miR‑141‑3p as a molecular sponge to upregulate the expression level of USP22. High CTBP1‑AS2 expression was associated with advanced clinical stage and lymph node metastasis of patients. Yes High CTBP1‑AS2 expression was associated with advanced clinical stage and lymph node metastasis of patients. 35039872 CTBP1-DT LncRNA Homo sapiens Nasopharyngeal carcinoma NPC cells Interaction(miR-140-5p/BMP2 Axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay CTBP1-AS2 was upregulated in NPC cells.cCTBP1-AS2 silencing in SUNE-1 cells raised miR-140-5p expression and repressed BMP2 level. CTBP1-AS2 overexpression in CNE-1 cells suppressed miR- 140-5p expression and elevated BMP2 levels. Yes CTBP1-AS2 silencing suppressed NPC cell proliferation and promoted apoptosis. 35894463 CTBP1-DT LncRNA Homo sapiens Glioma glioma tissues regulation[miR-370-3p-Wnt7a axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//migration assay The lncRNA CTBP1-AS2 had increased expression profiles in tumor tissues, which is associated with poor prognosisThis study provides new insights that a novel lncRNA, CTBP1-AS2, regulates EMT of glioma by modulating the miR-370-3p-Wnt7a axis. The lncRNA CTBP1-AS2 had increased expression profiles in tumor tissues, which is associated with poor prognosis Yes In detail, CTBP1-AS2 knockdown decreased proliferation and migration phenotypes in both U87-MG and LN229 cells. 33150795 CTXND1 LncRNA Homo sapiens Stomach Neoplasms GC cells Regulation[Wnt/β-catenin signaling pathway] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Microarray//Transwell Assay LINC01314 was poorly expressed in GC cells and KLK4 was revealed to be a direct target gene of LINC01314. Overexpressed LINC01314 or silencing of KLK4 led to inhibited GC cell migration and invasion, corresponding to decreased Wnt-1, β-catenin, cyclin D1 and N-cadherin while increased E-cadherin. Yes Overexpressed LINC01314 or silencing of KLK4 led to inhibited GC cell migration and invasion, corresponding to decreased Wnt-1, β-catenin, cyclin D1 and N-cadherin while increased E-cadherin. 31007611 CYTOR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Expression[highly expressed] CCK8//qRT-PCR Finally, the potential function of two lncRNAs (CASC9 and LINC00152) that were upregulated in OC tissues and associated with patients' survival time was verified by loss-of-function assays in OC cells. Moreover, lots of lncRNAs expression levels are associated with OC patients' overall survival and recurrence-free survival; for example, higher CASC9, LINC01232, and MIR4435-1HG expression levels are related to shorter overall survival and recurrence-free survival in OC patients. Yes Next, CCK8 assays showed that knockdown of CASC9 and LINC00152 inhibited SCC4 and SCC25 cells’ proliferation compared with control cells (Fig. 4c–f). 30543527 CYTOR LncRNA Homo sapiens Glioma gliomas tissues Interaction(miR-107/RAB10 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis In this study, we found that LINC00152 was upregulated in gliomas and its expression was significantly associated with high tumor aggressiveness and poor outcomes for glioma patients.Mechanistically, results of the bioinformatics analysis and experimental studies confirmed that LINC00152 and RAB10 as the targets of miR-107, and LINC00152 might act as a sponge for miR-107 to regulate the expression of RAB10 in glioblastoma. Additionally, silencing miR-107 reversed the effects induced by LINC00152 knockdown on glioblastoma cells both in vitro and in vivo. In this study, we found that LINC00152 was upregulated in gliomas and its expression was significantly associated with high tumor aggressiveness and poor outcomes for glioma patients. Yes Functionally, the knockdown of LINC00152 not only inhibited malignant behaviors of glioma, such as proliferation and invasion of glioma cells and induced apoptosis in vitro but also suppressed tumorigenesis in vivo. 34478013 CYTOR LncRNA Homo sapiens Leukemia, Lymphoid normal B cells and Chronic Lymphocytic Leukemia B cell clones Expression(highly expressed) qRT-PCR Higher LINC00152 levels were consistently observed in memory B cell populations when compared to naïve B cells in the normal tissues analyzed [peripheral blood (PB), tonsils, and spleen]. In addition, independent stimulation via Immunoglobulins (IG), CD40, or Toll-like Receptor 9 (TLR9) upregulated LINC00152 in PB B cells. The expression of LINC00152 in a cohort of 107 early stage Binet A CLL patients was highly variable and did not correlate with known prognostic markers or clinical evolution. TLR9 stimulation, but not CD40 or IG challenge, was able to upregulate LINC00152 expression in CLL cells. In addition, LINC00152 silencing in CLL cell lines expressing LINC00152 failed to induce significant cell survival or apoptosis changes. These data suggest that, in normal B cells, the expression of LINC00152 is regulated by immunomodulatory signals, which are only partially effective in CLL cells. The expression of LINC00152 in a cohort of 107 early stage Binet A CLL patients was highly variable and did not correlate with known prognostic markers or clinical evolution.LINC00152 does not appear to contribute to CLL cell expansion and/or survival in a cohort of newly diagnosed CLL patients. Yes LINC00152 silencing in CLL cell lines expressing LINC00152 failed to induce significant cell survival or apoptosis changes. 34679195 CYP24A1 LncRNA Homo sapiens Ovarian Neoplasms Ovarian Cancer tissues Regulation qRT-PCR Moreover, we found that the most upregulated lncBCAS1-4_1 showed 75% same transcripts with CYP24A1 (metabolic enzyme of 1α,25(OH)2D3). Furthermore, lncBCAS1-4_1 could resist the antitumor effect of 1α,25(OH)2D3, which was associated with upregulated ZEB1. Yes Finally, the lncBCAS1-4_1 gain-of-function cell model was established, which demonstrated that the knockdown of lncBCAS1-4_1 inhibited the proliferation and migration of ovarian cancer cells. 34422647 CYB561-5 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(Bsg) qRT-PCR//Western Blot Lnc-CYB561-5 is highly expressed in human NSCLC and is associated with a poor prognosis in lung adenocarcinoma. In addition, RNA pulldown and RNA immunoprecipitation (RIP) assays show that basigin (Bsg) protein interacts with lnc-CYB561-5. Overall, this study demonstrates that lnc-CYB561-5 is an oncogene in NSCLC, which is involved in the regulation of cell proliferation and metastasis. Lnc-CYB561-5 is highly expressed in human NSCLC and is associated with a poor prognosis in lung adenocarcinoma. Yes In vivo, downregulation of lnc-CYB561-5 significantly decreases tumour growth and metastasis. In vitro, lnc-CYB561-5 knockdown treatment inhibits cell migration, invasion and proliferation ability, as well as glycolysis rates. 35064752 CWC27 CircRNA Homo sapiens Alzheimer Disease AD mice and patients Interaction(Pur-α) ChIP//Transfection//RIP//PCR//IP//IF CircCwc27 was a neuronal-enriched circRNA that abundantly expressed in the brain and significantly upregulated in AD mice and patients. CircCwc27 directly bound to purine-rich element-binding protein A (Pur-α), increased retention of cytoplasmic Pur-α, and suppressed Pur-α recruitment to the promoters of a cluster of AD genes, including amyloid precursor protein (APP), dopamine receptor D1 (Drd1), protein phosphatase 1, regulatory inhibitor subunit1B (Ppp1r1b), neurotrophic tyrosine kinase, receptor, type 1 (Ntrk1), and LIM homeobox 8 (Lhx8). Downregulation of circCwc27 enhanced the affinity of Pur-α binding to these promoters, leading to altered transcription of Pur-α targets. Yes Knockdown of circCwc27 markedly improved AD-related pathological traits and ameliorated cognitive dysfunctions. 34504314 CUX1 CircRNA Homo sapiens Neuroblastoma NB tissues regulation[miR-16-5p/DMRT2 Axis] colony Formation Assay//Flow Cytometry//qRT-PCR//RIP//MTT//PCR//IP//Colony Formation Assay//IF Circ-CUX1 was highly expressed in NB tissues (n = 50) than that in FAM tissues (n = 50) (Fig. 1a). In conclusion, circ-CUX1 accelerated the proliferation, migration, invasion and glycolysis of NB cells through targeting miR-16-5p/DMRT2 signaling cascade. Yes Circ-CUX1 promoted the proliferation, migration, invasion and glycolysis of NB cells. 33000435 CUL2 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cell lines Interaction(miR-208a-3p/PPP6C) Northern Blot//Western Blot//Transfection//Flow Cytometry//PCR//IP//ChIP The expression level of circCUL2 was down-regulated in colorectal cancer tissues and cell lines. Luciferase assay verified that miR-208a-3p could bind with circCUL2/PPP6C. Overexpression of circCUL2 could inhibit cancer progression via targeting the miR-208a-3p/PPP6C signal pathway. Yes Forcing expression of circCUL2 inhibited proliferation ability, induced apoptosis, and autophagy in colorectal cancer cells. 35027503 cTFRC CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Interaction[MicroRNA-107] qRT-PCR//Western Blot//PCR//IF We detected circular RNA-cTFRC Expression[Expression[up-expression]-expression]-regulated and correlated with tumor grade and poor survival rate of BC patients. Furthermore, the expression of cTFRC correlated with TFRC and negatively correlated with miR-107 both in BC cell lines and BC clinical samples. In addition, Expression[Expression[up-expression]-expression]-regulation of cTFRC promoted TFRC expression and contributed to an epithelial to mesenchymal transition phenotype in BC cells. Finally, we found that cTFRC acts as a competing endogenous RNA (ceRNA) for miR-107 to regulate TFRC expression. We detected circular RNA-cTFRC Expression[Expression[up-expression]-expression]-regulated and correlated with tumor grade and poor survival rate of BC patients. Yes Knock Expression[down-expression] of cTFRC inhibited invasion and proliferation of BC cell lines in vitro and tumor growth in vivo. 30782157 CTBP1-DT LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines regulation[miR-3163 ,ZNF217] RNA Pull-Down//TUNEL//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay CTBP1-AS2 was significantly overexpressed in CC cell lines.CTBP1-AS2 regulates CC progression via sponging miR-3163 to up-regulate ZNF217. Yes Knockdown of CTBP1-AS2 curbed cell proliferation, migration and invasion, while stimulated cell apoptosis in vitro. CTBP1-AS2 facilitated xenograft tumor growth in vivo. 32742190 CTD-3252C9.4 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer cells and tissues Interaction(IFI/IRF1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Invasion Assay//ChIP CTD-3252C9.4 was found remarkably decreased in pancreatic cancer cells and tissues. Then, IFI6 was identified as a downstream target that could be down-regulated by CTD-3252C9.4 and IFI6 overexpression could counteract the effects of CTD-3252C9.4 upregulation on the survival and apoptosis of pancreatic cancer cells. Furthermore, mechanism experiments revealed that IRF1 was a transcriptional factor of IFI6 that can be blocked by CTD-3252C9.4 to inhibit IFI6 transcription. Yes Overexpression of CTD-3252C9.4 suppressed migration, invasion and proliferation, yet facilitated apoptosis of pancreatic cancer cells both in vitro and in vivo. 34399768 CTD-2245E15.3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation(ACC1 and PC ) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Colony Formation Assay CTD-2245E15.3 was significantly upregulated in NSCLC and was mainly located in the cytoplasm. CTD-2245E15.3 exerted its oncogenic function by binding ACC1 and PC, which are key anabolic factors for biomolecule synthesis in rapidly proliferating tumor cells. Knockdown of CTD-2245E15.3 increased phosphorylation of ACC1 at an inhibitory site for enzymatic activity and promoted PC degradation via ubiquitination. Yes Knockdown of CTD-2245E15.3 by specific antisense oligonucleotides suppressed cell growth in vitro and in vivo, largely due to cell-cycle arrest and induction of apoptosis. Overexpression of CTD-2245E15.3 in an orthotopic model of lung cancer led to a significant increase in total tumor burden. 33941610 CTC-497E21.4 LncRNA Homo sapiens Stomach Neoplasms GC tissues,cell lines Regulation[RhoA signaling pathway] qRT-PCR//FISH CTC-497E21.4 was upregulated in GC tissues and GC cell lines (P < 0.05).Mechanistic investigations indicated that CTC-497E21.4 acted as a ceRNA for miR-22 and regulated NET1 expression. CTC-497E21.4/miR-22-3p/NET1 participated in the RhoA signaling pathway in the GC progression. CTC-497E21.4 was upregulated in GC tissues and GC cell lines (P < 0.05), and the expression was associated with depth of invasion, lymph node metastasis, and neurological invasion. Yes Besides, knockdown of CTC-497E21.4 inhibited cell proliferation, invasion and promoted cell cycle arrest in vitro and inhibited tumorigenesis in vivo. 31451992 CTC-338M12.3 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 CTBP1-DT LncRNA Homo sapiens Stomach Neoplasms GC tissues, cell lines regulation[miR-139-3p/MMP11 Axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining CTBP1-AS2 was highly expressed in GC, and its high expression was strongly associated with increased TNM stage, increased tumor size and low degree of differentiation of the tumor tissues. CTBP1-AS2 was highly expressed in GC, and its high expression was strongly associated with increased TNM stage, increased tumor size and low degree of differentiation of the tumor tissues. Yes Meanwhile, CTBP1-AS2 promoted GC cell proliferation, metastasis and suppressed apoptosis, while miR-139-3p could weaken these effects. 33204108 CTBP1-DT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC samples and cells regulation[SP1/CTBP1-AS2/miR-195-5p/CEP55 axis] qRT-PCR We found that CTBP1-AS2 expressions were increased in HCC samples and cells. Overall, an emerging regulatory mechanism of SP1/CTBP1-AS2/miR-195-5p/CEP55 axis was reported in the paper, which possibly served as a new therapeutic HCC treatment target. As revealed by the clinical assays, high CTBP1-AS2 expression usually related to lymph node metastasis, clinical stage and weaker prognosis specific to HCC patients. Yes Functionally, CTBP1-AS2 knockdown suppressed HCC cells in terms of the proliferation, migration, invasion, chemotherapy resistance as well as EMT progress, but promoted apoptosis. 32988587 CTBP1-DT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-623/Cyclin D1 Axis] CCK8//qRT-PCR The downregulation of CTBP1-AS2 in HCC was confirmed by measuring the expression level of CTBP1-AS2 in both HCC and nontumor tissues from HCC patients. Therefore, CTBP1-AS2 promotes cell proliferation in HCC by regulating the miR-623/cyclin D1 axis. Yes CCK-8 analysis showed that CTBP1-AS2 and cyclin D1 overexpression promoted the proliferation of HCC cells. 32522013 CTBP1-DT LncRNA Homo sapiens Ovarian Neoplasms OC tissues regulation[miR-216a/ PTEN] qRT-PCR//Luciferase Report Assay We found that CTBP1-AS2 was downregulated in OC and predicted poor survival. CTBP1-AS2 regulates miR-216a/PTEN to suppress OC cell proliferation. We found that CTBP1-AS2 was downregulated in OC and predicted poor survival. Yes CTBP1-AS2 and PTEN overexpression resulted in the reduced proliferation rate of OC cells and reduced effects of miR-216a overexpression. 32711584 chr2:206992521|206994966 CircRNA Homo sapiens Psoriasis psoriatic lesions skin Expression[differently expression] qRT-PCR//PCR To explore potential circRNA-mediated mechanisms of S-MSCs in the pathogenesis of psoriasis, we sequenced mRNAs and circRNAs of MSCs from normal skin and psoriatic lesions, followed by functional prediction and interaction analyses. In total, 129 circRNAs were differentially expressed, including 123 Expression[Expression[up-expression]-expression]-regulated and 6 Expression[down-expression]-regulated circRNAs, in MSCs from psoriatic lesions. Yes KnockExpression[down-expression] of the circRNA gene chr2:206992521|206994966 reduced the capacity of S-MSCs to inhibit T-cell proliferation Expression[Expression[up-expression]-expression]on co-culture in normal as well as lesion-derived S-MSCs. 30664808 CHEK1 CircRNA Homo sapiens Multiple Myeloma MM cells Expression(highly expressed) In Vivo Experiment//Western Blot//Transfection//Co-IP//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay//IF We demonstrated that CHEK1 expression was significantly increased in human MM samples relative to normal plasma cells, and that in MM patients, high CHEK1 expression was associated with poor outcomes. Increased CHEK1 expression induced MM cellular proliferation and evoked drug-resistance in vitro and in vivo. CHEK1-mediated increases in cell proliferation and drug resistance were due in part to CHEK1-induced CIN. CHEK1 activated CIN, partly by phosphorylating CEP170. Interestingly, CHEK1 promoted osteoclast differentiation by upregulating NFATc1 expression. Intriguingly, we discovered that MM cells expressed circCHEK1_246aa, a circular CHEK1 RNA, which encoded and was translated to the CHEK1 kinase catalytic center. Transfection of circCHEK1_246aa increased MM CIN and osteoclast differentiation similarly to CHEK1 overexpression, suggesting that MM cells could secrete circCHEK1_246aa in the BM niche to increase the invasive potential of MM cells and promote osteoclast differentiation. and that in MM patients, high CHEK1 expression was associated with poor outcomes. Yes Increased CHEK1 expression induced MM cellular proliferation and evoked drug-resistance in vitro and in vivo. 34090465 CBR3-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-145-5p) qRT-PCR//Western Blot High-expression levels of CBR3-AS1 were found in CRC tissues and cell lines. Moreover, we observed that CBR3-AS1 could directly bind to miR-145-5p and negatively regulated its expression in CRC. Further experiments also demonstrated that inhibition of miR-145-5p reverted the effects of CBR3-AS1 knockdown on CRC cells. In addition, compared with the parental cells, CBR3-AS1 expression was strikingly increased in oxaliplatin- (OXA-) resistant CRC cells, and the OXA resistance was notably diminished by CBR3-AS1 knockdown. Upregulated CBR3-AS1 was closely associated with poor prognosis and adverse clinicopathological features of CRC patients. Yes . Artificial knockdown of CBR3-AS1 markedly suppressed the proliferation, migration, invasion, and stem-like properties but promoted the apoptosis of CRC cells. 35466320 CCHE1 LncRNA Homo sapiens Urinary Bladder Neoplasms UBC cell and patients Regulation(ROCK1 ) qRT-PCR During the follow-up, plasma CCHE1 levels were significantly increased in UBC patients with DR but slightly decreased in patients with LR and NR. CCHE1 overexpression increased ROCK1 level in UBC cell lines, while ROCK1 overexpression failed to significantly affect CCHE1 expression. Moreover, CCHE1 and ROCK1 overexpression increased UBC cell migration and invasion, and ROCK1 silencing reduced the enhancing effects of CCHE1 overexpression on UBC cell migration and invasion. CCHE1 overexpression on the day of discharge distinguished DR patients from LR and NR patients and healthy controls. Moreover, significant and positive correlations between CCHE1 and ROCK1 on the day of discharge and during the follow-up were found across patients with DR. Yes CCHE1 overexpression increased ROCK1 level in UBC cell lines, while ROCK1 overexpression failed to significantly affect CCHE1 expression. Moreover, CCHE1 and ROCK1 overexpression increased UBC cell migration and invasion, and ROCK1 silencing reduced the enhancing effects of CCHE1 overexpression on UBC cell migration and invasion. 36017913 CCEPR LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Expression[highly expressed] Western Blot//Migration Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The results demonstrated that CCEPR expression was significantly higher in colorectal cancer tissues when compared with paired adjacent normal tissues.Finally, silencing of CCEPR downregulated matrix metalloproteinase (MMP)-2 and MMP-9 expression and suppressed epithelial-mesenchymal transition in colorectal cancer cells. In addition, CCEPR expression was significantly higher in patients with advanced colorectal cancer (stage III/IV) than those with early-stage colorectal cancer (stage I/II). High CCEPR expression was significantly associated with poor differentiation, advanced clinical stage, positive lymph node metastasis and distant metastasis. Yes In vitro experiments demonstrated that the expression of CCEPR was increased in colorectal cancer cell lines when compared with a normal colon cell line. Knockdown of CCEPR significantly inhibited colorectal cancer cell proliferation, colony formation and cell cycle progression, as well as cell migration and invasion. 31602230 CCEPR LncRNA Homo sapiens Ovarian Neoplasms OC tissues regulation[ Wnt/β-catenin signaling pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay CCEPR expression levels were significantly elevated in OC tissues compared with adjacent non?cancer tissues.In conclusion, the present study demonstrated that increased expression levels of CCEPR may predict poor prognosis in patients with OC and contribute to the progression of OC through regulating the Wnt/β‑catenin signaling pathway. The increased expression levels of CCEPR were associated with increased invasion, higher International Federation of Gynecology and Obstetrics stage and a poorer overall survival rate. Yes In vitro, the genetic silencing of CCEPR decreased the cell proliferation rate and invasive ability of OC cells, and promoted apoptosis. 32319633 CCDC66 CircRNA Homo sapiens Colorectal Neoplasms CRC tissue Interaction(miR-370/MDM4 ) qRT-PCR//Luciferase Report Assay//Transwell Assay This study showed that circRNA CCDC66 was overexpressed in CRC tissues, and after knockdown, it inhibited the proliferation, migration, and invasion of CRC cells (RKO and HCT-116) in vitro. In addition, the dual-luciferase reporter assay showed that there was a binding site between circCCDC66 and miR-370, as well as between miR-370 and murine double minute 4 (MDM4). That is, circCCDC66 upregulated the expression of MDM4 through competitively binding to miR-370. The expression of circCCDC66 in CRC tissues was positively correlated with MDM4 and negatively correlated with miR-370. Yes This study showed that circRNA CCDC66 was overexpressed in CRC tissues, and after knockdown, it inhibited the proliferation, migration, and invasion of CRC cells (RKO and HCT-116) in vitro. 35069793 CCDC66 CircRNA Homo sapiens Osteoarthritis OA cartilage tissues Interaction(miR-3622b-5p/SIRT3 axis) Transfection//Western Blot//PCR//IF It was found that circCCDC66 expression in OA cartilage tissues was upregulated. CircCCDC66 promoted OA chondrocyte apoptosis by regulating the miR-3622b-5p/SIRT3 axis. CircCCDC66 may be a new therapeutic target of OA. Yes CircCCDC66 overexpression inhibited proliferation and promoted apoptosis of chondrocytes and increased IL-6 and TNF-α levels in chondrocytes. 34979511 CCDC26 LncRNA Homo sapiens Thyroid Neoplasms patients' thyroid cancer tissues and thyroid cancer cell lines Interaction(miR-422a/EZH2/Sirt6 Axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//BrdU//Colony Formation Assay//Transwell Assay CCDC26 expression was elevated in patients' thyroid cancer tissues and thyroid cancer cell lines. Tumorigenicity analysis in nude mice revealed that CCDC26 contributed to thyroid tumor growth via miR-422a/EZH2/Sirt6 axis in vivo. Yes CCDC26 depletion remarkably reduced proliferation, invasion, and migration but induced apoptosis of thyroid cancer cells. 34007185 CCDC196 LncRNA Homo sapiens Liver Neoplasms cells Interaction(miR‑522) In Vivo Experiment//RNA Pull-Down//Transfection//Immunoblotting//Migration Assay//qRT-PCR//Colony Formation Assay//Invasion Assay LINC00238 was identified as a downregulated molecule in The Cancer Genome Atlas liver hepatocellular carcinoma dataset through Gene Expression Profiling Interactive Analysis software.Mechanistically, RNA pull‑down assays showed that LINC00238 sponged microRNA (miR)‑522 and then reversed the inhibitory effects on two downstream targets, secreted frizzled related protein 2 and dickkopf1. Yes Through gain? and loss?of?function experiments, LINC00238 was confirmed as a tumor suppressor that could not only decrease cell viability, migration and invasion in vitro, but also tumorigenesis and tumor metastasis in vivo. 35014686 CCDC183-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-589-5p/SKP1 ) qRT-PCR Significantly upregulated expression of CCDC183-AS1 was observed in both HCC tissues and cell lines. HCC patients with higher expression of CCDC183-AS1 had a poorer overall survival rate. Mechanistically, CCDC183-AS1 acted as a ceRNA through sponging miR-589-5p to offset its inhibitory effect on the target gene SKP1, then promoted the tumorigenesis of HCC. Significantly upregulated expression of CCDC183-AS1 was observed in both HCC tissues and cell lines. HCC patients with higher expression of CCDC183-AS1 had a poorer overall survival rate. Yes Functionally, overexpression of CCDC183-AS1 markedly promoted HCC cell proliferation, migration and invasion in vitro and tumor growth and metastasis in vivo, whereas the downregulation of CCDC183-AS1 exerted opposite effects. MiR-589-5p inhibitor counteracted the proliferation, migration and invasion inhibitory effects induced by CCDC183-AS1 silencing. 33541391 CCDC183-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Regulation(TCF7L2) qRT-PCR//Luciferase Report Assay Novel molecular mechanisms for developing effective diagnostic and therapeutic strategies are urgently needed; therefore, we screened the lncRNA expression profile in four pairs of BC tissues, showing that CCDC183-AS1 was the most upregulated lncRNA. Subsequently, results of CCK-8, EdU, Transwell, and aerobic glycolysis detection showed that CCDC183-AS1 plays an oncogene role in BC progression. Furthermore, an investigation of the downstream and upstream factors of CCDC183-AS1 identified a novel MITF/CCDC183-AS1/miR-4731-5p/TCF7L2 axis in BC progression, which might furnish novel insights for developing effective diagnostic and therapeutic strategies for BC. Yes Subsequently, results of CCK-8, EdU, Transwell, and aerobic glycolysis detection showed that CCDC183-AS1 plays an oncogene role in BC progression. 35957803 CCDC144NL-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[CCDC144NL-AS1/miR-143-3p/MAP3K7 axis] IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Herein, we report lncRNA CCDC144NL-AS1, which has not been explored in GC, and it is markedly upregulated in GC tissues, which may serve as an independent predictor of poor prognosis. Taken together, our results elucidate the oncogenic roles of CCDC144NL-AS1/miR-143-3p/MAP3K7 axis in GC progression, providing inspiration for further understanding of the mechanism of GC and making CCDC144NL-AS1 as a potential novel diagnostic and therapeutic target for GC. We found that CCDC144NL-AS1 expression was significantly positively associated with a larger tumor size and more pronounced lymph node metastasis. Yes Through a series of in vivo and in vitro functional experiments, we observed that CCDC144NL-AS1 could facilitate cell proliferation, invasion and migration and inhibit cell apoptosis in GC. 32647147 CCDC144NL-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer cells Expression(highly expressed) CCK8//qRT-PCR//Wound Healing Assay The survival analysis showed that high expression of CCDC144NL antisense RNA 1 (CCDC144NL-AS1) and LINC01614 was positively correlated with the poor prognosis of patients with gastric cancer. The in vitro validation results showed that CCDC144NL-AS1 and LINC01614 were both up-regulated in the gastric cancer cells. The survival analysis showed that high expression of CCDC144NL antisense RNA 1 (CCDC144NL-AS1) and LINC01614 was positively correlated with the poor prognosis of patients with gastric cancer. Yes Silence of CCDC144NL-AS1 and LINC01614 both significantly suppressed the cell proliferation and migration of gastric cancer cells, and also promoted the chemosensitivity of gastric cancer cells to 5-fluorouracil. 35083139 CCDC144NL-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-490-3p) Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay The expression of lncRNA CCDC144NL-AS1 was enhanced in both NSCLC tissues and cell lines. LncRNA CCDC144NL-AS1 might target miR-490-3p. Patients with overexpression of lncRNA CCDC144NL-AS1 have a poor prognosis, and lncRNA CCDC144NL-AS1 is an independent prognostic factor for NSCLC. Yes Increased the relative expression level of lncRNA CCDC144NL-AS1 can promote the proliferation, migration, and invasion of NSCLC cells. 34115289 CCDC144NL-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-363-3p/GALNT7) qRT-PCR//Luciferase Report Assay//IHC//FISH CCDC144NL-AS1 was up-regulated in CRC tissues and cells. The study demonstrated that the CCDC144NL-AS1/miR-363-3p/GALNT7 axis exerts on key roles in cell proliferation and presents an emerging target for CRC therapy and prognostic biomarker. High CCDC144NL-AS1 was connected with the adverse clinicopathological features and worse prognosis of CRC. Yes Furthermore, knockdown of CCDC144NL-AS inhibited the cell proliferation and led to the cell cycle G0-1/S arrest, whereas upregulated CCDC144NL-AS1 obtained the inverse results. Further study found that CCDC144NL-AS1 functioned as ceRNAs in regulating CRC proliferation. 35154444 CCDC144NL-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue Interaction(miR-940/WDR5-regulated epigenetic pathway) CCK8//qRT-PCR//IHC//ChIP CCDC144NL-AS1 was significantly upregulated in HCC tissue and had a marked relationship with the 5-year prognosis. In vitro study revealed that CCDC144NL-AS1 was highly expressed in HCC cell line MHCC97H but lowly expressed in normal hepatic cell line L02. CCDC144NL-AS1 was found to sponge miR-940 to induce the expression of WD repeat domain 5 (WDR5). ChIP-seq analysis identified that matrix metalloproteinase (MMP) 2, MMP9, and cyclin-dependent kinase (CDK) 1, CDK2, and CDK4 were all targets of WDR5. Yes Overexpression of CCDC144NL-AS1 in L02 enhanced the invasion and proliferation abilities of cells but inhibited the apoptosis rate. Knockdown of CCDC144NL-AS1 in MHCC97H weakened the invasion and proliferation abilities of cells but increased the apoptosis rate. 33977095 CCDC144NL-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck rOSCC and OSCC-LNM Regulation(PI3K-AKT-mTOR pathway) qRT-PCR//Western Blot//Transwell Assay The expressions of the lncRNAs, namely MAGI2-AS3 and CCDC144NL-AS1, were significantly upregulated in rOSCC and OSCC-LNM. MAGI2-AS3 was overexpressed in cancer tissue compared to other control groups. MAGI2-AS3 and CCDC144NL-AS1 might promote cell proliferation, invasion, and migration in OSCC cells by regulating the PI3K-AKT-mTOR pathway. Yes MAGI2-AS3 and CCDC144NL-AS1 might promote cell proliferation, invasion, and migration in OSCC cells by regulating the PI3K-AKT-mTOR pathway. 36401978 CCDC144NL-AS1 LncRNA Homo sapiens Endometriosis EC tissues Expression[highly expressed] qRT-PCR CCDC144NL-AS1 expression was upregulated in EC tissues compared to EU and normal endometrial (NE) tissues. Yes CCDC144NL-AS1 depletion suppressed the migration and invasion of hEM15A cells, but exerted no effects on cell adhesion, proliferation, apoptosis, or cell cycle. 30496345 CCAT2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction(β-catenin/WISP1 axis) CCK8//qRT-PCR//Transwell Assay//Western Blot CCAT2 was overexpressed in ESCC tissues compared with corresponding adjacent tissues. Furthermore, knockdown of CCAT2 could suppress the mRNA and protein levels of β-catenin and Wnt-induced-secreted-protein-1 (WISP1), as well as the mRNA levels of their downstream targets VEGF-A, MMP2, and ICAM-1. High expression of CCAT2 and WISP1 were associated with poor prognosis of ESCC patients. Yes CCAT2 knockdown could suppress cell proliferation and invasion in vitro. 34057837 CCAT2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cells and tissue Interaction(miR-200b / IGF2BP2/TK1 Axis) qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Upregulated CCAT2, IGF2BP2, and TK1 expression and inhibited miR-200b expression were observed in ESCC cells and tissues. CCAT2 bound to miR-200b and reduced its expression, leading to upregulated IGF2BP2 expression. IGF2BP2 improved TK1 mRNA stability to enhance its expression by recognizing its m6A modification. Yes CCAT2 promoted the migration and invasion of ESCC cells in vitro, and tumorigenesis in vivo by upregulating TK1 expression, while overexpression of miR-200b reversed these effects of CCAT2. 34386421 CCAT2 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Expression[highly expressed] Flow Cytometry//qRT-PCR It was found through differential expression analysis that the expression of lncRNA CCAT2 showed a significant difference in CRC tissues, and CRC patients with a high expression level of lncRNA CCAT2 had poor prognosis.Based on the results of qRT-PCR assay, lncRNA CCAT2 was significantly highly expressed in CRC tissues. It was found through differential expression analysis that the expression of lncRNA CCAT2 showed a significant difference in CRC tissues, and CRC patients with a high expression level of lncRNA CCAT2 had poor prognosis. Yes LncRNA CCAT2 can promote the growth and proliferation and suppress the apoptosis of CRC cells. 33099922 CCAT2 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation(RAB14/AKT/GSK3β signaling pathway) CCK8//qRT-PCR//Western Blot Our results showed that CCAT2 was upregulated in CRC tissues and cell lines as com-pared to controls. Ectopic expression of CCAT2 promoted CRC cell proliferation, migration and invasion, likely through direct interaction with TAF15, transcriptional activation of RAB14, and activation of the AKT/GSK3β signaling pathway. Yes Ectopic expression of CCAT2 promoted CRC cell proliferation, migration and invasion, likely through direct interaction with TAF15, transcriptional activation of RAB14, and activation of the AKT/GSK3β signaling pathway. In vivo, CCAT2 promoted CRC cell growth and metastasis in nude mice. 34868956 CCEPR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Expression[highly expressed] Western Blot//CCK8//qRT-PCR//migration assay//Colony Formation Assay//Invasion Assay In the present study, CCEPR mRNA expression level was upregulated in ESCC tissues and cell lines, and overexpression of CCEPR was associated with advanced TNM stage, lymph node metastasis, and poor prognosis in ESCC. In the present study, CCEPR mRNA expression level was upregulated in ESCC tissues and cell lines, and overexpression of CCEPR was associated with advanced TNM stage, lymph node metastasis, and poor prognosis in ESCC. Yes In vitro experiments showed that silencing CCEPR mRNA expression levels significantly suppressed the proliferation, migration, and invasion of ESCC cells, while inducing ESCC cell apoptosis. 32934710 CCHE1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue and cells Expression(highly expressed) CCK8//qRT-PCR//Western Blot We found that the CCHE1 was highly expressed in the NSCLC tissue, compared with the adjacent tissue. We also found that the expression of CCHE1 was closely related to the size and survival time of patients. Yes Moreover, CCHE1 could promote the proliferation, metastasis, and invasion of NSCLC cell line via increasing the expression of ERK/MAPK signaling pathway. 29630113 CCAT2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissue regulation[CCAT2/miR-145/MDM2 axis ] qRT-PCR//Luciferase Report Assay In the present study, we found that CCAT2 was abnormally upregulated in HCC cells and tissue specimens, exhibiting an inverse correlation with microRNA (miR)-145 expression. Furthermore, a novel CCAT2/miR-145/MDM2 axis was revealed in HCC development and might provide a new target in the molecular treatment of HCC. Yes Both the in vitro and in vivo effects of CCAT2 knockdown on the proliferation and metastasis of HCC cells were reversed by miR-145 inhibitor, indicating that miR-145 modulation accounts for CCAT2-meditated HCC progression. 32037568 CCHE1 LncRNA Homo sapiens Colonic Neoplasms blood Interaction[interleukin-17A] CCK8//qRT-PCR//Western Blot In the present study, the expression levels of CCHE1 and interleukin (IL)-17A were increased in the plasma of patients with metastatic and non-metastatic colon adenocarcinoma (MC and NMC, respectively) compared with the healthy controls. Transfection of small interfering RNA against IL-17A partially reversed the effects of CCHE1 overexpression on cancer cell proliferation. Upregulation of IL-17A was observed after CCHE1 overexpression, while IL-17A overexpression did not significantly change the expression level of CCHE1. Therefore, CCHE1 may promote growth of colon adenocarcinoma through interactions with IL-17A. The plasma expression levels of CCHE1 and IL-17A were positively associated with the primary tumor diameter. Yes CCHE1 and IL-17A overexpression promoted colon adenocarcinoma cell proliferation. 31423215 CDC6 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[target CDC6 by sponging microRNA-215] qRT-PCR Clinically, lncRNA-CDC6 was highly expressed in tumor tissues and was positively correlated with clinical stages of breast cancers.Moreover, lncRNA-CDC6 could function as competitive endogenous RNA (ceRNA) via directly sponging of microRNA-215 (miR-215), which further regulating the expression of CDC6. Taken together, our results proved that lncRNA-CDC6 could function as ceRNA and promote the proliferation and metastasis of breast cancer cells, which provided a novel prognostic marker for breast cancers in clinic. Clinically, lncRNA-CDC6 was highly expressed in tumor tissues and was positively correlated with clinical stages of breast cancers. Yes Functionally, the ectopic expression of lncRNA-CDC6 promoted proliferation via regulation of G1 phase checkpoint, and further promoting the migration capability. 30362551 Cdc14a CircRNA Mus musculus Ischemic Stroke plasma and peri-infarct cortex of tMCAO mice Expression(highly expressed) In Vivo Experiment//FISH//qPCR The expression of circCDC14A in plasma and peri-infarct cortex of tMCAO mice significantly increased, and circCDC14A was mainly localized in neutrophils peripherally while in astrocytes in peri-infarct cortex centrally. Yes Tail vein injection of lentivirus to interfere with the expression of circCDC14A significantly reduced the infarct volume (P < 0.01) at 72 h after reperfusion and density of activated astrocytes in peri-infarct cortex at 3 days, 5 days and 7 days after tMCAO modeling (all P < 0.0001). Moreover, mNSS (P < 0.0001) and survival rate (P < 0.001) were significantly improved within 7 days in si-circCDC14A group compared to circCon group. Additionally, morphology analysis showed the volume and surface area of each activated astrocytes significantly decreased (P < 0.0001). 34876161 CD82-AS1 LncRNA Homo sapiens Diabetic Nephropathies DKD patients and high-glucose-induced human podocytes Interaction(HuR) Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Transwell Assay In this study, we found that the expression of lncRNA 254693 was increased in both DKD patients and high-glucose-induced human podocytes. Then, we did bioinformatics analysis via RBPDB and found that lncRNA 254693 can combine with HuR, a RNA binding protein. Meanwhile, immunofluorescence and in situ hybridization double staining was used to prove the existence of colocalization between them. Intriguingly, lncRNA 254693 knockdown decreased HuR levels, while HuR knockdown also decreased the level of lncRNA 254693 and its stability. Yes Downregulation of lncRNA 254693 remarkably reversed the elevation of inflammation, apoptosis, and podocyte injury caused by high glucose. 35493610 CD27-AS1-208 LncRNA Homo sapiens Melanoma melanoma cell Regulation(STAT3) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//migration assay//Colony Formation Assay//Invasion Assay Further, we identified lncRNA CD27-AS1-208 as a novel nuclear-localized factor with prominent facilitative role in melanoma cell proliferation, invasion and migration. Mechanistically, CD27-AS1-208 could directly interact with STAT3 and contribute to melanoma progression in a STAT3-dependent manner. Yes Further, we identified lncRNA CD27-AS1-208 as a novel nuclear-localized factor with prominent facilitative role in melanoma cell proliferation, invasion and migration. Ultimately, the role of CD27-AS1-208 in melanoma progression in vivo was also investigated. 35096622 CD27-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML patients (N = 40) Interaction(miR-224-5p/PBX3 signaling) qRT-PCR//Luciferase Report Assay In present study, we found that the expression of CD27-AS1 examined by quantitative real-time PCR was markedly increased in the AML patients (N = 40) compared with healthy volunteers (N = 40). Additionally, CD27-AS1 was proved to increase PBX3 expression through sponging miR-224-5p. CD27-AS1 knockdown blocked the MAPK signaling through PBX3 silencing and further inhibited the cell growth of AML cells. The overall survival time was significantly shorter in patients with higher CD27-AS1 expression than that in patients with lower CD27-AS1 (P < 0.01). Yes Furthermore, downregulation of CD27-AS1 in AML cells suppressed proliferative ability, arrested cell cycle in G0/G1 phase, and induced apoptosis. However, CD27-AS1 overexpression further enhanced the malignant phenotype of AML cells. 34006845 CD226 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung serum exosomes, tissues and cells of NSCLC Interaction( miR-1224-3p/HMGA2 axis) RNA Pull-Down//Western Blot//Transfection//Cell Viability Assay//PCR//IP//Invasion Assay//IF The abundance of circCD226 was elevated in serum exosomes, tissues and cells of NSCLC. Mechanistically, circCD226 sponged miR-1224-3p, and miR-1224-3p targeted HMGA2. CircCD226 involved the posttranscriptional regulation of HMGA2 through miR-1224-3p. Moreover, the miR-1224-3p/HMGA2 axis was identified as a functionally downstream effector of circCD226 in regulating NSCLC cell behaviors. Yes NSCLC serum exosomes enhanced NSCLC cell proliferation, migration, invasion and stemness. Loss of circCD226 impeded cell proliferation, migration, invasion and stemness in vitro , as well as tumor growth in vivo . 35946568 CD209 LncRNA Homo sapiens Stomach Neoplasms cell lines Regulation[JAK2/STAT3 signaling pathway] qRT-PCR//MTT//Colony Formation Assay//Western Blot In this study, the results showed that DC-SIGN was highly expressed in GC cells and significantly correlated with advanced clinical stage and lymphatic metastasis. Mechanistically, knockdown of DC-SIGN inactivated the JAK2/STAT3 signaling pathway, and overexpression of DC-SIGN activated the JAK2/STAT3 signaling pathway. In addition, through LncPath microarray analysis, we identified a lncRNA, RP11-181G12.2, that was significantly upregulated after knockdown of DC-SIGN; this was also confirmed by qRT-PCR. Furthermore, RP11-181G12.2 knockdown enhanced DC-SIGN expression in GC cells, further activating the JAK2/STAT3 signaling pathway. In contrast, DC-SIGN overexpression suppressed RP11-181G12.2 expression. Yes Downregulation of DC-SIGN significantly inhibited the proliferation, cell cycle progression, migration and invasion of GC cells in vitro. 31766099 cCSC1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,colorectal cancer stem cells Regulation[Hedgehog signaling pathway] IHC//Western Blot//Wound Healing Assay//qRT-PCR//FISH//Colony Formation Assay we identified a novel lncRNA (lncRNA-cCSC1) that is highly expressed in CRC and colorectal cancer stem cells (CRCSCs). Furthermore, aberrant lncRNA-cCSC1 expression resulted in a concomitant alteration of smoothened (SMO) and GLI family zinc finger 1 (Gli1) expression in the Hedgehog (Hh) signaling pathway. Our study is the first to identify a novel lncRNA-cCSC1 in CRC and to indicate that it may regulate CSC-like properties via the Hh signaling pathway. Thus, lncRNA-cCSC1 could be a potential biomarker and promising therapeutic target for CRC. Yes The depletion of lncRNA-cCSC1 markedly inhibited the self-renewal capacity of the CRCSCs and reduced their drug resistance to 5-fluorouracil. In contrast, lncRNA-cCSC1 overexpression increased the self-renewal effect. 31680315 cCSC1 LncRNA Homo sapiens Colorectal Neoplasms CRC cell lines Interaction(lncRNA-cCSC1/miR-124-3p axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Our results showed that cell proliferation of CRC was promoted by lncRNA-cCSC1 upregulation and inhibited by lncRNA-cCSC1 downregulation. In addition, miR-124-3p is predicted to be the target of lncRNA-cCSC1 and is negatively correlated with lncRNA-cCSC1. Moreover, the addition of miR-124-3p mimics or inhibitor reversed the effects induced by lncRNA-cCSC1 overexpression or silencing on cell proliferation of CRC. Additionally, lncRNA-cCSC1 regulated the expression level of CD44, a target gene of miR-124-3p. Finally, we studied the effects of the lncRNA-cCSC1/miR-124-3p axis on CD44. Yes Our results showed that cell proliferation of CRC was promoted by lncRNA-cCSC1 upregulation and inhibited by lncRNA-cCSC1 downregulation. 33887588 cCNTNAP3 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma esophageal tissue regulation[p53] Western Blot//ISH//qRT-PCR//RIP//FISH//PCR//Microarray//IP//IHC//IF However, we found that the cCNTNAP3 expression level was significantly downregulated in ESCC tissues. In conclusion, the cCNTNAP3-TP53 positive feedback loop may provide a potential target for the management of ESCC, which also reveals the important role of circRNAs in the regulation of p53. Yes In vitro and in vivo studies revealed that cCNTNAP3 inhibited proliferation and increased apoptosis in p53 wild-type ESCC cells, but not in mutant cells. 33239613 CCND2-AS1 LncRNA Homo sapiens Breast Neoplasms BC epithelial cells Expression(highly expressed) Migration Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay CCND2-AS1 expression was significantly over-expressed compared to normal breast epithelial cells. Yes Gain-and loss-of-function experiments were performed in vitro to investigate the role of CCND2-AS1, where we found that CCND2-AS1 knockdown in MDA-MB-231 significantly suppressed cell proliferation, migration, and invasion. In contrast, CCND2-AS1 overexpression in BT-549 had the opposite effects. 31938243 CCND2-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical tissues Expression[lower expressed] qRT-PCR CCND2 AS1 expression was lower in cervical cancer compared with normal cervical tissues, and the level was significantly correlated with the patient age and tumor size. Yes CCND2 AS1 overexpression inhibited the proliferation and cell cycle progression of HeLa cells in vitro and/or in vivo, whereas CCND2 AS1 silencing had the opposite effects. 32607313 CCND1 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cell lines interaction[HuR and miR-646] Western Blot//qPCR//RIP//PCR//IP//IF circ-CCND1 was found to be markedly up-regulated in laryngeal squamous cell carcinoma (LSCC) and closely associated with aggressive clinical features and adverse prognosis. Regarding the mechanism, circ-CCND1 physically bound to human antigen R (HuR) protein to enhance CCND1 mRNA stability; on the other hand, circ-CCND1 could act as an effective sponge for miR-646 to alleviate the repression of miR-646 on CCND1 mRNA. circ-CCND1 was found to be markedly up-regulated in laryngeal squamous cell carcinoma (LSCC) and closely associated with aggressive clinical features and adverse prognosis. Yes Depletion of circ-CCND1 significantly inhibited LSCC cell proliferation in vitro and retarded tumour growth in vivo. 31951319 CCMAlnc LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines interaction[CCMAlnc/miR-5001-5p/HES6 signaling] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Elevated CCMAlnc was detected in CRC cells as well as in clinical CRC tissue samples, and the expression of this lncRNA positively correlated with the poor prognosis of CRC patients. Elevated CCMAlnc was detected in CRC cells as well as in clinical CRC tissue samples, and the expression of this lncRNA positively correlated with the poor prognosis of CRC patients. Yes Functional validation assays revealed that downregulation of CCMAlnc impaired CRC cell proliferation and invasion in vitro, but upregulation of CCMAlnc reversed this effect. 33681178 CCL2 LncRNA Homo sapiens Stomach Neoplasms tumor cell lines (HGC-27 and MKN-45) Interaction(miR-128/ PARP2 signal pathway) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay CCL2 expression and PARP2 protein levels were up-regulated, while miR-128 expression was obviously lower. All over these results showed lncRNA CCL2 played importance of role in gastric tumor via miR-128/PARP2 axis signal pathway. Yes Meanwhile, CCL2 down-regulating significantly repressed the proliferation, migration, and invasion by regulating miR-128. PARP2-si obviously suppressed in gastric cancer proliferation, migration, and invasion. Meanwhile, miR-128 mimic and the knockout of CCL2 distinctly decreased PARP2 protein level. 35000531 CCHE1 LncRNA Homo sapiens Stomach Neoplasms tumor cell lines Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay Expression of lncRNA CCHE1 in the tumor cell lines was increased (p<0.05). Yes Up-regulated lncRNA CCHE1 increased proliferative activity and colony formation capacity. 29771412 CCHE1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells interaction[PAK2,miR-922] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay qRT-PCR analysis identified the upregulation of CCHE1 in OSCC cells.CCHE1 increases the expression of PAK2 to promote the progression of OSCC by competitively binding to miR-922 in OSCC cells. Yes Knockdown of CCHE1 curbed the proliferation, migration, and invasion and hastened the apoptosis in OSCC cell lines. 31981240 CCHE1 LncRNA Homo sapiens pancreatic adenocarcinoma blood Interaction[ROCK1] ELISA//Transwell Assay//Western Blot The results of the present study demonstrated that, compared with healthy controls, CCHE1 and ROCK1 were upregulated in the serum of patients with metastatic pancreatic adenocarcinoma.ROCK1 small interfering RNA-induced silencing partially reversed the enhancing effects of CCHE1 overexpression on cancer cell migration and invasion. Therefore, lncRNA-CCHE1 may be involved in migration and invasion but not in proliferation of pancreatic adenocarcinoma cells, possibly by interacting with ROCK1. Yes CCHE1 overexpression promoted the migration and invasion of human pancreatic adenocarcinoma cell lines, but no significant effects on cell proliferation were identified. 31423182 CCHE1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC cell lines regulation[MEK/ERK/c-MYC pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay Elevated levels of CCHE1 were verified in NPC cell lines.The present study suggested that downregulation of lncRNA CCHE1 could inhibit cell proliferation, migration and invasion by suppressing MEK/ERK/c-MYC pathway in nasopharyngeal carcinoma. Yes Downregulation of CCHE1 significantly inhibited tumor growth and suppressed A549 cell proliferation, migration and invasion. 32964977 CCAT2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction[up-regulating NDRG1] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this study, we found that CCAT2 were significantly elevated in HCC tissues and cell lines.All these observations demonstrate that CCAT2 acts as an oncogene by up-regulating NDRG1, which may have the potential to be used as a promising prognostic biomarker and therapeutic target for HCC. Yes In this study, we found that CCAT2 were significantly elevated in HCC tissues and cell lines, and it promoted HCC cells proliferation and metastasis both in vitro and in vivo. 30922920 CCAT2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue Interaction(miR-4496/Atg5 Axis) qRT-PCR//Western Blot In our study, we found that lncRNA CCAT2 expression was significantly increased in HCC tissue and was correlated with advanced stage and venous invasion. Mechanistic investigations found that CCAT2 involved in HCC by regulating miR-4496/Atg5 in cytoplasm. In nucleus, CCAT2 bound with ELAVL1/HuR to facilitate HCC progression. In our study, we found that lncRNA CCAT2 expression was significantly increased in HCC tissue and was correlated with advanced stage and venous invasion. Yes Further experiments revealed that CCAT2 induced autophagy and promoted migration and invasion in vitro and in vivo. 34409736 CHASERR LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues regulation[NF-κB/YY1 axis] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//ChIP LINC01578 was upregulated in colon cancer, associated with metastasis, advanced clinical stages, poor overall survival, disease-specific survival, and disease-free survival. Collectively, this study demonstrated that LINC01578 promoted colon cancer metastasis via forming a positive feedback loop with NF-κB/YY1 and suggested that LINC01578 represents a potential prognostic biomarker and therapeutic target for colon cancer metastasis. LINC01578 was upregulated in colon cancer, associated with metastasis, advanced clinical stages, poor overall survival, disease-specific survival, and disease-free survival. Yes Gain-of-function and loss-of-function assays revealed that LINC01578 enhanced colon cancer cell viability and mobility in vitro and colon cancer liver metastasis in vivo. 33040438 CCAT1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[highly expressed] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay CCAT1 was signifi cantly upregulated in bladder cancer (P < 0.05). CCAT1 upregulation was positively related to tumor stage (P = 0.004), tumor grade (P = 0.001) and tumor size (P = 0.042). Yes Cell proliferation, migration and invasion were promoted by abnormally expressed CCAT1 31038865 CCAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cell lines regulation[ERK/AKT pathway] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry The findings revealed that CCAT1expression was upregulated in OSCC cell lines. Downregulation of CCAT1 suppressed TCA-8113 cell proliferation, invasion, and migration by inactivation of the ERK/AKT pathway via inhibition of DDR2, suggesting the value of CCAT1 in diagnosis and treatment of patients with OSCC. Yes Knockdown of CCAT1 repressed cell proliferation, blocked the cell cycle, and suppressed the invasion and migration of TCA-8113 cells. 32009633 CCAT1 LncRNA Homo sapiens Endometrial Neoplasms cell lines Interaction[sponge of miR-181a-5p] CCK8//qRT-PCR//Western Blot//Transwell Assay The expression level of CCAT1 was significantly upregulated in EC tissue samples compared with matched adjacent healthy tissue samples from patients with endometrial cancer. The results suggest that CCAT1 promotes EC progression by acting as a molecular sponge of miR-181a-5p. Yes Cell counting kit-8 and Transwell migration assays demonstrated that CCAT1 knockdown significantly decreased EC cell proliferation and migration. 30988798 CCAT1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Regulation[miR-181a-5p/MMP14 axis] CCK8//qRT-PCR//Transwell Assay The expression of CCAT1 in the cervical cancer tissues was higher than in the adjacent normal tissues. Elevated CCAT1 suppressed miR-181a expression, which was accompanied by an increased expression of MMP14 and HB-EGF. In contrast, knocking down CCAT1 resulted in increased expression of miR-181a, along with decreased expression of MMP14 and HB-EGF. Thus, CCAT1 is a key oncogenic lncRNA associated with cervical cancer and plays a role in promoting cervical cancer cell proliferation and invasion by regulating the miR-181a-5p/MMP14 axis. Yes Overexpressing CCAT1 promoted cervical cancer cell proliferation, colony formation, and invasion in vitro. 31084453 CCAT1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Regulation[miR-218/ZFX signaling] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay Additionally, CCAT1 expression was higher in TNBC patient tumor tissue than adjacent normal breast tissue. Bioinformatics analysis revealed that microRNA-218 (miR-218) is a potential target of CCAT1. Silencing CCAT1 resulted in an increase in miR-218 expression and inhibited TNBC cell proliferation, migration, and invasion. Silencing miR-218 reversed the effects of CCAT1 knockdown on cell proliferation, migration, and invasion, suggesting that CCAT1 promotes TNBC progression by downregulating miR-218 expression. We identified the zinc finger protein ZFX as a putative downstream target of miR-218 through bioinformatics analysis. ZFX expression was higher in TNBC than normal breast cell lines and higher in TNBC tumor tissue than adjacent normal breast tissue. Overexpression of ZFX reversed the tumor-suppressive effects of miR-218 on TNBC cell proliferation, migration, and invasion. Yes Silencing CCAT1 inhibited TNBC cell proliferation, migration, and invasion in vitro, and tumor growth and progression in vivo. 31310241 CCAT1 LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues Expression[highly expressed] qRT-PCR//Transwell Assay//Western Blot In the current study, the expression of CCAT1 was identified to be increased in lung adenocarcinoma tissues (n=96) by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and its expression level was associated with epidermal growth factor receptor (EGFR) expression (P=0.011), lymphatic metastasis (P=0.003) and tumor node metastasis (TNM) stage (P=0.003). In the current study, the expression of CCAT1 was identified to be increased in lung adenocarcinoma tissues (n=96) by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and its expression level was associated with epidermal growth factor receptor (EGFR) expression (P=0.011), lymphatic metastasis (P=0.003) and tumor node metastasis (TNM) stage (P=0.003). Yes In vitro, by using Transwell assays, the overexpression of CCAT1 was demonstrated to promote the migration and invasion of H358 lung adenocarcinoma cells; while downregulation of CCAT1 expression inhibited H1650 cell migration and invasion. 30008869 CCAT1 LncRNA Homo sapiens Adenocarcinoma of Lung LAD tissue regulation[Suppressing miR-219-1] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//cell invasion assay In this study, we found LAD tissue samples had a higher expression of CCAT1 but a lower expression of miR-219-1 compared to their adjacent non-tumor tissues. In summary, our findings suggested that CCAT1 promotes the progression of LAD via sponging miR-219-1, providing a potential therapeutic target for LAD. Yes Knockdown of CCAT1 inhibited the proliferation, migration, and invasion of A549 and H1299 cells, which were reversed by the miR-219-1 inhibitor. 33193573 CCAT1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and LUAD cells Regulation(PI3K/AKT/mTOR signalling) In Vivo Experiment//Western Blot//ISH//Transfection//Co-IP//qRT-PCR//RIP//IF//Luciferase Report Assay//EdU Staining//ChIP We identified the upregulation of CCAT1 in LUAD tissues and LUAD cells. Moreover, we found that CCAT1 regulated the activity of AKT by promoting the ubiquitination of FKBP51 through binding with USP49. Yes Subsequently, cell function assays revealed the enhancement of CCAT1 on LUAD cell proliferation and angiogenesis in vitro and in vivo. 34431227 CCAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Hep-2 and TU177 cells Interaction(miR-218-5p/BMI1) Western Blot//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay Our results depicted that CCAT1 was highly-expressed in Hep-2 and TU177 cells. Mechanically, CCAT1 regulated the BMI1 expression by competitively binding to miR-218-5p as a competing endogenous RNA (ceRNA), and thus facilitated the growth of Hep-2 and TU177 cells. Downregulation of miR-218-5p or upregulation of BMI1 inhibited the inhibitory effect of silencing CCAT1 on Hep-2 and TU177 cell proliferation, invasion, and migration. Yes Silencing CCAT1 inhibited the proliferation, migration, and invasion of Hep-2 and TU177 cells. 35261819 CCAT1 LncRNA Homo sapiens Prostatic Neoplasms Expression[highly expressed] qRT-PCR//MTT//Transwell Assay Increased CCAT1 was significantly related to lymph node metastasis in prostate cancer. Increased CCAT1 was significantly related to lymph node metastasis in prostate cancer. Yes Low-expression of CCAT1 could suppress cell proliferation. Knockdown of CCAT1 inhibited the migration of PC-3 cells. Down-regulation of CCAT1 attenuated the invasion of PC-3 cells. 29863242 CCAT1 LncRNA Homo sapiens Prostatic Neoplasms Interaction[DDX5 and MIR-28-5P] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//ChIP In this study, we found from The Cancer Genome Atlas and Memorial Sloan Kettering Cancer Center database that CCAT1 is highly upregulated in castration-resistant prostate cancer (CRPC) compared with androgen-dependent prostate cancer (ADPC). Mechanistically, in cytoplasm, CCAT1 sponges MIR-28-5P to prevent the anticancer effect. In nucleus, CCAT1 acts as a scaffold for DDX5 (P68) and AR transcriptional complex to facilitate the expression of AR-regulated genes, thus stimulating CRPC progression. Our findings suggest that CCAT1 is an oncogenic factor in the progression of CRPC with different regulatory mechanisms in the nucleus and cytoplasm of cells. Yes In vitro and in vivo studies show that CCAT1 promotes prostate cancer cell proliferation as well as the tumor growth of prostate cancer xenografts. 31387890 CCAT1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC cell line and tissues Interaction(miR-130a-3p axis) qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Transwell Assay CCAT1 was upregulated and miR-130a-3p was downregulated in ccRCC cell line and tissues (all P < 0.05). There was a negative association between CCAT1 and miR-130a-3p expression (r = - 0.373, P = 0.010). MiR-130a-3p mimic and si-CCAT1 inhibited ccRCC cell proliferation and invasion, and induced apoptosis. High CCAT1 and low miR-130a-3p expression was correlated with larger tumor size and advanced TNM stage in ccRCC patients. High CCAT1 level suggested a poor survival prognosis. Yes There was a negative association between CCAT1 and miR-130a-3p expression (r = - 0.373, P = 0.010). MiR-130a-3p mimic and si-CCAT1 inhibited ccRCC cell proliferation and invasion, and induced apoptosis. 33482824 CCAT1 LncRNA Homo sapiens Retinoblastoma RB cell lines Interaction(miR-218-5p/MTF2 axis) Western Blot//Transfection//qPCR//migration assay//Luciferase Report Assay//cell invasion assay Previously, we have demonstrated that lncRNA colon cancer-associated transcript 1 (CCAT1) in two RB cell lines SO-RB50 and Y79 was obviously overexpressed, and notably, lncRNA CCAT1 attenuated miR-218-5p expressionand induced proliferation, cell migration and invasion. Functional analysis and rescue analysis showed that lncRNA CCAT1 via competitive binding to miR-218-5p to modulate MTF2 expression thus accelerate EMT, cell migration and invasion of RB. Yes Previously, we have demonstrated that lncRNA colon cancer-associated transcript 1 (CCAT1) in two RB cell lines SO-RB50 and Y79 was obviously overexpressed, and notably, lncRNA CCAT1 attenuated miR-218-5p expressionand induced proliferation, cell migration and invasion. 34265414 CCAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues regulation[suppressing miR-152] qRT-PCR//MTT//Western Blot//Transwell Assay CCAT1 expression levels significantly increased in NSCLC tumor tissues and were associated with poor overall survival of NSCLC patients. Long non-coding RNA CCAT1 regulates tumor cell proliferation and invasion in NSCLC through suppressing miR-152. CCAT1 expression levels significantly increased in NSCLC tumor tissues and were associated with poor overall survival of NSCLC patients. Yes CCAT1 promotes cell proliferation, cell invasion and epithelial-mesenchymal transition of NSCLC cell lines. 32227563 CCAT1 LncRNA Homo sapiens Osteoporosis bone tissues and osteoblasts of ovariectomized rats with osteoporosis Interaction(miR-34a-5p/SMURF2) In Vivo Experiment//RNA Pull-Down//Western Blot//Tunel//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay CCAT1 and SMURF2 were amplified while miR-34a-5p expression was inhibited in bone tissues and osteoblasts of ovariectomized rats with osteoporosis. LncRNA CCAT1 could competitively bind with miR-34a-5p to prevent the degradation of its target gene SMURF2. Yes Inhibited CCAT1 improved pathology and restricted osteocyte apoptosis of bone tissues in ovariectomized rats with osteoporosis in vivo, and also enhanced differentiation, mineralization abilities, and proliferation, and suppressed apoptosis of osteoblasts from ovariectomized rats in vitro through upregulating miR-34a-5p expression. 33402731 CCAL LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Regulation[CCAL/miR-149/FOXM1 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay We observed that CCAL was upregulated in gastric cancer tissues and was associated with the tumour-node-metastasis stage. These results demonstrated that the CCAL/miR-149/FOXM1 axis functions as a key regulator in gastric cancer metastasis and CCAL potentially represents a biomarker for diagnosis and potential target for therapy in the future. We observed that CCAL was upregulated in gastric cancer tissues and was associated with the tumour-node-metastasis stage. Yes Functional experiments showed that CCAL promoted gastric cancer cell proliferation and metastasis in vitro and in vivo. 30250169 CCAL LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues regulation[MiR-29b/ANGPTL4 Axis ] Western Blot//qRT-PCR//Luciferase Report Assay//ELISA//IHC Compared with noncancerous tissues, the expression of CCAL was markedly upregulated in osteosarcoma tissues.Our results show that CCAL promotes angiogenesis by regulating the miR-29b/ANGPTL4 axis in osteosarcoma. Higher CCAL expression levels were closely related to shorter overall survival in patients with osteosarcoma. Yes Additionally, functional analysis indicated that CCAL could facilitate tumour angiogenesis in vitro and in vivo in osteosarcoma. 33122950 CBR3-AS1 LncRNA Homo sapiens Breast Neoplasms breast tissues Expression[Expression[highly expressed]-expression] qRT-PCR//MTT Our results showed that CBR3-AS1 was overexpressed in breast cancer tissues and cell lines and predicted the prognosis of breast cancer patients. Yes We first examined the effect of CBR3-AS1 on cell proliferation in the four breast cancer cell lines. MTT assay revealed that CBR3-AS1 knockdown significantly inhibited cell viability in breast cancer cells at 48 or 72 h after treatment with si-CBR3-AS1 (Fig. 3B–E). At the same time, ectopic expression of CBR3-AS1 in breast cancer cells obviously accelerated the cell proliferation (Fig. 3G–J). Furthermore, stable knockdown of CBR3-AS1 resulted in decreased colony formation (Fig. 4A, P < 0.001), as well as CBR3-AS1 overexpression obviously promoted the colony formation of breast cancer cells (Fig. 4B, P < 0.001). In addition, it was also found that CBR3-AS1 was involved in the regulation of cell apoptosis in breast cancer. Stable knockdown of CBR3-AS1 significantly inducted cell apoptosis (Fig. 4C, P < 0.001), whereas overexpression of CBR3-AS1 possessed an obvious reduction in the proportion of apoptotic cells (Fig. 4D, P < 0.001). 34530987 CBR3-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Expression[highly expressed] qRT-PCR//MTT Our results showed that CBR3-AS1 was overexpressed in breast cancer tissues and cell lines and predicted the prognosis of breast cancer patients. Yes And CBR3-AS1 exerted biological function as an oncogenic lncRNA, involved in the regulation of cell proliferation, colony formation, apoptosis and tumor growth in breast cancer. 32550547 CBR3-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue Interaction(miR-409-3p/SOD1 axis) Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot Here, we demonstrate CBR3-AS1 overexpression in NSCLC tissue compared with adjacent normal tissue. CBR3-AS1 may regulate the expression and functions of the miR-409-3p target gene SOD1.CBR3-AS1 downregulation decreased post-irradiation SOD1 expression, increased γH2AX formation, raised levels of reactive oxygen species, and promoted apoptosis. Yes CBR3-AS1 downregulation reduced proliferation, invasion, and migration; inhibited cell cycle progression; and promoted apoptosis of NSCLC cells. CBR3-AS1 also promoted tumor growth in vivo. 34801596 CCAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Regulation[Wnt/β-catenin signaling pathway] RIP//Western Blot//qRT-PCR CCAT1 was upregulated in OSCC tissues and cell lines.Luciferase and RIP assays revealed that miR-181a was a direct target of CCAT1. Inhibition of miR-181a partially reversed the efficacy of sh-CCAT1. Moreover, sh-CCAT1 inhibited OSCC tissues growth through inhibiting Wnt signaling in a miR-181a-dependent manner in vivo. lncRNA CCAT1 activated Wnt/β-catenin signaling via inhibiting miR-181a, resulting in the cell proliferation, migration and invasion of OSCC, suggesting that CCAT1 might serve as a potential target of OSCC treatment. Yes Knockdown of CCAT1 inhibited the proliferation, migration and invasion of OSCC cells, while the cell apoptosis was enhanced. 31599709 CCAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[as miR-30c-2-3p sponge] qRT-PCR//MTT//Luciferase Report Assay//Western Blot In this study, we demonstrated that CCAT1 was highly expressed in HCC tissues and remarkably associated with metastasis. In general, CCAT1 regulate the expression of CCNE1 by acting as a ceRNA to sponge miR-30c-2-3p in regulating the cell proliferation of HCC. Yes ". MTT assay in Hep3B and HepG2 cells showed that overexpressing CCAT1 promoted the cell proliferation (Figures 2C and S1A in the Supporting Information), whereas knock down of CCAt1 suppressed the cell proliferation (Fig_x0002_ures 2D and S1B)." 30773676 CCAT2 LncRNA Homo sapiens Esophageal Neoplasms cell lines Regulation[Wnt signaling pathway] qRT-PCR//Wound Healing Assay//MTT//Transwell Assay The expression of CCAT2 was significantly decreased in si-CCAT2 Eca-109 cells. Treatment with si-CCAT2 and FH535 alone or in combination significantly inhibited the proliferation, migration and invasion of Eca-109 cells. The treatments also promoted apoptosis, upregulated the expression of Bax and APC proteins, and downregulated β-catenin, PCNA, cyclin D1 and c-Myc proteins. Yes Treatment with si-CCAT2 and FH535 alone or in combination significantly inhibited the proliferation, migration and invasion of Eca-109 cells. 31423241 CCAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[sponging miR-181] Luciferase Report Assay//IF CCAT1 levels were higher in tissue and cell lines of HCC. Our results show that, mechanistically, CCAT1 promotes autophagy through functioning as a sponge for miR-181a-5p, and then regulating ATG7 expression. Yes In function research, we found that CCAT1 facilitates HCC cell autophagy and cell proliferation. 31218739 CCAT2 LncRNA Homo sapiens Glioma NHA cells interaction[sponging miR-424] Flow Cytometry//qRT-PCR//Colony Formation Assay//Western Blot LncRNA CCAT2 and VEGFA were highly expressed, while miR-424 was expressed at low levels in NHA cells.The oncogenic lncRNA CCAT2 is highly associated with the development of glioma and exerts its function by upregulating VEGFA via miR-424. Yes Furthermore, knockdown of lncRNA CCAT2 decreased cell proliferation, increased cell apoptosis and inhibited endothelial angiogenesis in glioma. 32236863 CCAT2 LncRNA Homo sapiens Thyroid Neoplasms TC tissues and cell lines regulation[Wnt/β-catenin pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay CCAT2 expression was increased in TC tissue samples and cell lines compared with the controls. In summary, the present study demonstrated that CCAT2 knockdown suppresses TC progression via inactivating the Wnt/β‑catenin cascade, indicating that suppressing CCAT2 and the Wnt/β‑catenin signaling pathway may be a promising therapeutic strategy for treating TC. Tissue CCAT2 level was associated with T stage and tumor?node?metastasis stage of TC. Yes Silencing CCAT2 inhibited TC cell proliferation, migration and invasion, and promoted TC cell cycle arrest and apoptosis. 33125134 CCAT2 LncRNA Homo sapiens Adenocarcinoma of Lung cell lines Interaction[binding miR-23b-5p] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay The expression of CCAT2 was upregulated obviously in lung adenocarcinoma cells.These findings indicated that CCAT2 may act as a competitive endogenous RNA (ceRNA) to regulate FOXC1 expression by competitively binding miR-23b-5p in lung adenocarcinoma. Yes Cell function analysis showed that upregulation of CCAT2 significantly promoted cell proliferation and migration, and reduction of CCAT2 inhibited cell migration and proliferation. 30548656 CCAT2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissue and serum samples Expression [highly expressed] RNA Pull-Down//IHC//CCK8//qRT-PCR//Flow Cytometry//IF//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CCAT2 was significantly upregulated in human LSCC tissue and serum samples, associated with larger tumor volume, higher clinical stage, and poorer differentiation status. CCAT2 was significantly upregulated in human LSCC tissue and serum samples, associated with larger tumor volume, higher clinical stage, and poorer differentiation status. Yes Lentivirus-mediated CCAT2 knockdown notably repressed the cell viability, colony formation, and DNA synthesis rate of LSCC. Screening of transcription factors revealed that YAP/TEAD activity was affected by CCAT2 in LSCC cells. 34515990 CCAT2 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues, cell lines regulation[Wnt/β-catenin signaling pathway] qRT-PCR//Western Blot In the present study, the reverse transcription-quantitative PCR (RT-qPCR) results indicated that CCAT2 expression was significantly upregulated in PCa tissues, and DU145 and PC3 cell lines compared with normal prostate tissues and the epithelial RWPE-1 cell line, respectively.Overall, the results indicated that CCAT2 regulated PCa via the Wnt/β-catenin signaling pathway; therefore, CCAT2 may exhibit key role during the progression of PCa and may serve as a therapeutic target for the disease. Yes Functional assays indicated that CCAT2 downregulation inhibited DU145 and PC3 cell proliferation, cell cycle, migration and invasion. 32831916 CCAT2 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells and tissues Interaction(microRNA-493-5p/CREB1 axis) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of CCAT2 was upregulated in CC cells and tissues.Mechanistically, CCAT2 functions as a competing endogenous RNA (ceRNA) to upregulate the expression of CREB1 by binding to miR-493-5p. The overexpression of CREB1 or downregulation of miR-493-5p antagonized the effect of CCAT2 knockdown on the proliferation and EMT of CC cells. Yes However, the knockdown of CCAT2 inhibited the proliferation and epithelial-mesenchymal transition (EMT) of CC cells in vitro and suppressed tumor growth in vivo. 34499007 CCAT2 LncRNA Homo sapiens Neuroblastoma cancer tissues of children with neuroblastoma Expression [highly expressed] Western Blot//Transfection//qRT-PCR//MTT//Transwell Assay lncRNA CCAT2 expression in cancer tissues of children with neuroblastoma was notably higher than that in corresponding paracancerous tissues (P < 0.05), and children with different tissue differentiation, tumor staging, and lymph node metastasis (LNM) showed notably different lncRNA CCAT2 expression (P < 0.05). Compared with HUVEC cells, SH-SY5Y and SK-N-SH cells showed notably up-regulated lncRNA CCAT2, and the expression of it in SH-SY5Y was higher than that in SK-N-SH cells (P < 0.05). In addition, children with neuroblastoma in the high lncRNA CCAT2 expression group showed lower 3-year survival rate than those in the low expression group (P < 0.05). Multivariate analysis revealed that tissue differentiation, tumor-node-metastasis staging, LNM, and lncRNA CCAT2 expression were all independent risk factors affecting the prognosis of children with neuroblastoma (all P < 0.05). Yes Moreover, according to the MTT assay, the si-CCAT2 group showed notably weakened cell viability and proliferation than the CCAT2-NC group (both P < 0.05), and SH-SY5Y cells in the former group were less active than those in the latter group in terms of migration and invasion. The cell apoptosis rate of SH-SY5Y cells in the si-CCAT2 was higher than that in the CCAT2-NC. 33475889 CCAT1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[ targeting miR-219-1 ] qRT-PCR The results exhibited the fact that CCAT1 was expressed higher in 57 GC tissue samples than in 57 paired adjacent normal tissue samples. The expression of CCAT1 was also increased in GC cell lines (MKN45, Hs746T, and SGC-7901) compared with the gastric epithelial cell line GES-1. In conclusion, these results suggested that CAT1 promotes the tumorigenesis and progression of GC by negatively regulating miR-219-1. Yes Finally, in vivo experiment indicated that tumor growth of GC was suppressed through knockdown of CCAT1. 31478245 CCAT1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer cells Interaction( miR-140-3p/ATG5) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//H&E Staining//IHC//Invasion Assay//Transwell Assay LncRNA CCAT1 was highly expressed in gastric cancer cells. LncRNA CCAT1 can bind to miR-140-3p and regulate its expression, while miR-140-3p further regulates the expression of ATG5. Yes LncRNA CCAT1 can promote the proliferation, migration, invasion, and autophagy activity of gastric cancer cells. Overexpression of LncRNA CCAT1 can promote tumor growth in nude mice. After LncRNA CCAT1 silencing, the positive expression rate of ATG5 in nude mice was low. 34417924 CCAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell line regulation[CCAT1/miR-490 molecular axis] qRT-PCR//Wound Healing Assay//Transwell Assay High expression of CCAT1 was observed in NSCLC tissues and cells, with low expression of miR-490.The CCAT1/miR-490 molecular axis has been shown to be important for the treatment of NSCLC. Yes CCAT1 promoted the proliferation and metastasis of H1299 and A549 cells, while miR-490 had the opposite effect. CCAT1 could specifically bind to miR-490 and regulate its expression. 33325119 CCAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-216a-5p/RAP2B axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay The expression of CCAT1 was elevated in NSCLC, and CCAT1 deletion could inhibit NSCLC cell proliferation, migration, and invasion but induce apoptosis in vitro as well as imped tumor growth in vivo. Taken together, CCAT1 deletion could inhibit cell progression in NSCLC through miR-216a-5p/RAP2B axis, indicating a novel pathway underlying NSCLC cell progression and providing new potential targets for NSCLC treatment. Yes The expression of CCAT1 was elevated in NSCLC, and CCAT1 deletion could inhibit NSCLC cell proliferation, migration, and invasion but induce apoptosis in vitro as well as imped tumor growth in vivo. 33023331 CCAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[ microRNA-218] CCK8//qRT-PCR//Cell Apoptosis Assay//Western Blot In the present study, we showed that lncRNA?CCAT1 was upregulated in NSCLC tissues. lncRNA‑CCAT1 enhances tumor growth in NSCLC by directly inhibiting miR‑218 and indirectly increasing BMI‑1 expression. High expression of lncRNA?CCAT1 was related to tumor growth and reduced survival rate. Yes In vitro and in vivo results demonstrated that lncRNA?CCAT1 knockdown suppressed tumor proliferation and induced apoptosis. 32323859 CCAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[miR-181b-5p/TUSC3 Axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay The relative mRNA expression levels of CCAT1 were significantly higher in CRC tissues and cell lines compared with the normal tissues or cells. Bioinformatics and luciferase reporter assays showed that miR-181b-5p was a direct target of CCAT1, and the expression of miR-181b-5p was negatively correlated with the expression of CCAT1 in CRC tissues. Furthermore, CCAT1 positively regulated the level of tumor sExpression[up-expression]pressor candidate 3 (TUSC3) by competing with miR-181b-5p in CRC cells. Yes CCAT1 knockdown significantly inhibited CRC cell proliferation in vitro and in vivo. 31807005 CCAT1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues regulation[miR-181a-5p] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay//Microarray//IHC Compared with matched adjacent normal tissues, CCAT1 expression in CRC tissues was significantly increased (P<0.001, Figure 1C).CCAT1 promoted cell proliferation, growth and mobility by targeting miR-181a-5p and the silence of CCAT1 increased the cell apoptosis. The CCAT1 expression was positively associated with cancer stage (American Joint Committee on Cancer stage, P<0.05). Yes Furthermore, Xenograft model was used to show that knockdown of CCAT1 inhibits tumor growth in vivo. 32380476 CCAT1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues regulation[CCAT1/miR-218 axis ] qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The present study revealed that CCAT1 is highly expressed in colorectal cancer tissues.Taken together, the present results identified that the CCAT1/miR-218 axis serves a key role in the regulation of colorectal cancer progression, which may be used as potential therapeutic target for the treatment of colorectal cancer. Yes The results revealed that when compared with the control group, CCAT1-short hairpin (sh)RNA significantly inhibited colorectal cancer cell (SW480) viability and decreased migration and invasiveness. 32256733 CCAT1 LncRNA Homo sapiens Colorectal Neoplasms colorectal tissues and cell lines Interaction(miR-4679/GNG10) qRT-PCR//Western Blot//H&E Staining In this study, we found that in both colorectal tissues and cell lines the level of lncRNA CCAT1 was increased.We then found that hsa-miR-4679 could bind to lncRNA CCAT1 directly, and with further functional analyses, we confirmed that lncRNA CCAT1 sponged hsa-miR-4679 to promote the progression of colorectal cancer. Next, we found that hsa-miR-4679 was directly bound to 3'UTR of GNG10 (guanine nucleotide-binding protein, gamma 10). GNG10 overexpression promoted the progression of colorectal cancer, and this phenotype could be reversed by miR-4679 mimics. Yes Downregulation of lncRNA CCAT1 inhibited the proliferation, migration, and invasion of colorectal cell lines and promoted apoptosis. 35005034 CCAT1 LncRNA Homo sapiens Colonic Neoplasms tumour tissues and cells Interaction(microRNA-24-3p and FSCN1) qRT-PCR//Luciferase Report Assay//Tunel//Western Blot LncRNA-CCAT1 and FSCN1 mRNA/protein were overexpressed, whereas miR-24-3p was down-regulated in the CT-genotyped patients and cells compared with those in the CC-genotyped patients and cells. MiR-24-3p was validated to target lncRNA-CCAT1 and FSCN1 mRNA, and the overexpression of CCAT1 could reduce the expression of miR-24-3p although elevating the expression of FSCN1. Yes Knockdown of lncRNA-CCAT1 partly reversed the suppressed growth of CT-genotyped tumours. And the knockdown of lncRNA-CCAT1 partly reversed the dysregulation of lncRNA-CCAT1 and FSCN1 mRNA/protein in rs67085638-CT + NC shRNA mice. 33709519 CDCA3P1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(CDCA3 mRNA at 1423-1455 region) qRT-PCR In this study, we found CDCA3 was a potential oncogenic factor in HCC and characterized the lncCDCA3L, which could inhibit CDCA3. LncCDCA3L is significantly downregulated in HCC and its expression level is associated with tumour size and can act as an independent risk factor affecting postoperative survival time in HCC patients. Mechanistically, lncCDCA3L can repress CDCA3 protein level and inhibit hepatocarcinogenesis by directly binding to CDCA3 mRNA at 1423-1455 region via a novel manner based on a hairpin structure motif. In this study, we found CDCA3 was a potential oncogenic factor in HCC and characterized the lncCDCA3L, which could inhibit CDCA3. LncCDCA3L is significantly downregulated in HCC and its expression level is associated with tumour size and can act as an independent risk factor affecting postoperative survival time in HCC patients. Yes Mechanistically, lncCDCA3L can repress CDCA3 protein level and inhibit hepatocarcinogenesis by directly binding to CDCA3 mRNA at 1423-1455 region via a novel manner based on a hairpin structure motif. 35230745 CDIPTOSP LncRNA Homo sapiens Liver Neoplasms HCC tissues and cells Interaction(hnRNP K/YAP1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Migration Assay//qRT-PCR//FISH//RIP//RNA-seq//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//ChIP Here, we discovered a conserved CT-lncRNA, named lnc-CTHCC, which was highly expressed in the testes and HCC. Mechanistically, lnc-CTHCC bound to heterogeneous nuclear ribonucleoprotein K (hnRNP K), which was recruited to the YAP1 promoter for its activation. Additionally, the N6-methyladenosine (m6A) modification was mediated by N6-adenosine-methyltransferase 70-kDa subunit (METTL3) and recognized by insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)/IGF2BP3, which maintained lnc-CTHCC stability and increased its expression in HCC. Yes A lnc-CTHCC-knockout (KO) mouse model further confirmed that the global loss of lnc-CTHCC inhibited the occurrence and development of HCC. In vitro and in vivo assays also showed that lnc-CTHCC promoted HCC growth and metastasis. 35122073 CDK6 CircRNA Homo sapiens Uterine Cervical Neoplasms several cervical cancer cells Interaction( miR-449a) colony Formation Assay//Western Blot//Flow Cytometry//qRT-PCR//RIP//PCR//IP//Colony Formation Assay//Invasion Assay//IF Finally, the results showed that circCDK6 level remarkably increased in several cervical cancer cells, especially in Hela and CaSki cells. The miR-449a was further confirmed to be a potential target of circCDK6, and its expression increased by silencing circCDK6. Yes The circCDK6 participated in tumorigenesis and cancer progression and might serve as a tumor suppressive factor in cervical cell progression via Epithelial-MesenchymalTransition (EMT) process by regulating miR-449a. 35152839 CERNA2 LncRNA Homo sapiens Glioma Glioma Tissue,cell lines( U251 and U87) Interaction[let-7b;PBX3 ] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Results showed that HOST2 and PBX3 were highly expressed in glioma tissue whereas let-7b was expressed at much lower levels. The expression of let-7b and PBX3 was detected by RT-qPCR and Western blot analysis after the silencing of lncRNA HOST2. The results showed (Fig. 3E) that the expression of let-7b increased and PBX3 decreased significantly (all P < 0.05) in the si-lncRNA HOST2 groExpression[Expression[up-expression]-expression] compared with the blank groExpression[Expression[up-expression]-expression] and the si-Con groExpression[Expression[up-expression]-expression]. These results suggested that lncRNA HOST2 functioned as a ceRNA and regulated the expression of PBX3 by competitively binding to let-7b. Yes Results showed that the high expression of HOST2 in gliomas inhibits the expression of target gene PBX3 induced by let-7b and promotes the development of gliomas. Our results were consistent with recent reports of some related lncRNA RNAs. For instance, knockExpression[down-expression] of lncRNA FOXD3 antisense RNA 1 inhibited the cell growth, migration, and invasion of malignant glioma cells 25. Another study showed that Expression[down-expression]-regulation of lncRNA CCAT2 inhibited cellular proliferation and invasion in glioma cells 26. However, our investigation was the first to demonstrate that knockExpression[down-expression] of lncRNA HOST2 expression may inhibit the growth, migration, and invasion in glioma cells. 30290058 CERNA2 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical carcinoma tissues Expression[highly expressed] qRT-PCR In our study, we found the CERNA2 expression was obviously increased in cervical carcinoma tissues compared with adjacent normal cervical tissues. In addition, we observed that metastatic lymph nodes exhibited high levels of CERNA2 expression in contrast to primary cervical carcinoma tissues. Furthermore, high CERNA2 expression was associated with advanced clinical stage, lymph node metastasis, distant metastasis poor histological grade, and short overall survival in cervical carcinoma patients. Moreover, high CERNA2 expression acted as an independent unfavorable predictor for overall survival in cervical carcinoma patients. Yes The cell migration and invasion assays in vitro suggested that knockdown of CERNA2 remarkably inhibited cell migration and invasion in cervical carcinoma. 30793356 CERNA2 LncRNA Homo sapiens Uterine Cervical Neoplasms HPV-positive CC tissues and cells Interaction[inhibition of let-7b ] Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay HOST2 was upregulated in HPV-positive CC tissues and cells, which could promote the proliferation, migration and invasion, but inhibit the apoptosis of HPV-positive CC cells via inhibition of let-7b. Yes Over-expressed HOST2 reduced let-7b expression, promoted proliferation migration and invasion and inhibited the apoptosis of CaSki and HeLa cells,silencing HOST2 or overexpressing let-7b enhanced the expression of let-7b, inhibited proliferation migration and invasion, and promoted the apoptosis of CaSki and HeLa cells, and let-7b mimic could reverse the promoting effect of HOST2 on the growth of CC cells. 30964163 CEP85L CircRNA Homo sapiens Stomach Neoplasms GC tissues regulation[NFKBIA,miR-942-5p] ISH//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that circ-CEP85L, which has not been studied in GC, was significantly downregulated in GC tissues and that decreased circ-CEP85L expression correlated significantly with a worse prognosis. Therefore, we conclude that circ-CEP85L promotes NFKBIA expression by acting as a sponge of miR-942-5p; thus, inhibiting GC proliferation and invasion. circ-CEP85L is a potential target in the treatment of GC. We found that circ-CEP85L, which has not been studied in GC, was significantly downregulated in GC tissues and that decreased circ-CEP85L expression correlated significantly with a worse prognosis. Yes The knockdown of circ-CEP85L promoted the proliferation and invasion of GC cells, which was reversed by overexpression of circ-CEP85L. 32026471 CEP128 CircRNA Homo sapiens Glioma glioma tissues,cell lines Expression[highly expressed] qRT-PCR Circular RNA CEP128 was upregulated in glioma tissues and cell lines. Yes Knockdown of circular RNA CEP128 inhibited cell proliferation 31599823 Cenpm-202 LncRNA Rattus norvegicus Heart Failure H9c2 cells Interaction(miR-215-5p/ZEB2 Axis) RNA Pull-Down//Luciferase Report Assay//Western Blot We found out that SOX2-OT level was increased by oxygen glucose deprivation/reoxygenation treatment in H9c2 cells. Silencing of SOX2-OT ameliorated cell injury by promoting cell viability, inhibiting cell apoptosis and reducing productions of collagens. Mechanistically, miR-215-5p was confirmed to bind with SOX2-OT after prediction and screening. In addition, we discovered that miR-215-5p negatively regulated zinc finger E-box binding homeobox 2 (ZEB2) protein level by directly binding with ZEB2 3' untranslated region. Finally, we verified that SOX2-OT aggravated cell injury by targeting ZEB2 in H9c2 cells. In conclusion, SOX2-OT aggravated heart failure in vivo and promoted H9c2 cell injury via the miR-215-5p/ZEB2 axis in vitro, implying a novel insight into heart failure treatment. Yes Silencing of SOX2-OT ameliorated cell injury by promoting cell viability, inhibiting cell apoptosis and reducing productions of collagens. Finally, we verified that SOX2-OT aggravated cell injury by targeting ZEB2 in H9c2 cells. 34321385 CELF1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung primary cancer tissues Interaction(miR-491-5p/EGFR axis) Western Blot//ISH//Wound Healing Assay//Transfection//CCK8//qRT-PCR//RIP//FISH//PCR//cell invasion assay//IP//Invasion Assay//IF circ_CELF1 is upregulated in primary cancer tissues from patients with NSCLC, and a high level of circ_CELF1, is associated with malignant characteristics and poor outcomes of patients with NSCLC. Mechanistically, through directly interacting with miR-491-5p, circ_CELF1 acted as a miRNA sponge that increased the expression of the miR-491-5p target gene EGFR, eventually promoting the progression of NSCLC and increasing cancer resistance to immunotherapy. primary cancer tissues Yes Enforced expression of circ_CELF1 exacerbated the malignant transformation of NSCLC cells. 34788230 C-E-Cad CircRNA Homo sapiens Glioblastoma GBM tissues Regulation(EGFR-STAT3 signalling) Northern Blot//ISH//Transfection//Immunoblotting//RIP//RNA-seq//PCR//IP//Invasion Assay//IF C-E-Cad is overexpressed in GBM and promotes glioma stem cell tumorigenicity. C-E-Cad activates EGFR independent of EGF through association with the EGFR CR2 domain using a unique 14-amino-acid carboxy terminus, thereby maintaining glioma stem cell tumorigenicity. Notably, inhibition of C-E-Cad markedly enhances the antitumour activity of therapeutic anti-EGFR strategies in GBM. Yes C-E-Cad activates EGFR independent of EGF through association with the EGFR CR2 domain using a unique 14-amino-acid carboxy terminus, thereby maintaining glioma stem cell tumorigenicity. Notably, inhibition of C-E-Cad markedly enhances the antitumour activity of therapeutic anti-EGFR strategies in GBM. 33664496 CEBPA-DT LncRNA Homo sapiens Liver Neoplasms liver cancer tissues Expression[highly expressed] qRT-PCR//MTT//Western Blot//Transwell Assay The expression of lncRNA CEBPA-AS1 increased significantly in liver cancer tissues (p<0.05). Meanwhile, CEBPA-AS1 expression was associated with tumor size, portal vein tumor thrombus and invasion and metastasis (p<0.05). Yes In vitro experiments indicated that downregulation of lncRNA CEBPA-AS1 could effectively reduce cell proliferation, invasion and EMT process. 31646559 CEBPA-DT LncRNA Homo sapiens Liver Neoplasms human HCC tissues Interaction(CEBPA-DT-hnRNPC-DDR2/β-catenin axis) Western Blot//Transfection//qRT-PCR//RNA-seq//Microarray//IHC//IF Our results suggested that CEBPA-DT promoted HCC metastasis through DDR2/β-catenin mediated activation of Snail1 via interaction with hnRNPC, indicating that the CEBPA-DT-hnRNPC-DDR2/β-catenin axis may be used as a potential therapeutic target for HCC treatment. CEBPA-DT was upregulated in human HCC tissues with postoperative distant metastasis and intimately related to the worse prognosis of HCC patients. Yes Silencing of CEBPA-DT inhibited the growth, migration and invasion of hepatoma cells in vitro and in vivo, while enhancement of CEBPA-DT played a contrasting role. Mechanistic investigations demonstrated that CEBPA-DT could bind to heterogeneous nuclear ribonucleoprotein C (hnRNPC), which facilitated cytoplasmic translocation of hnRNPC, enhanced the interaction between hnRNPC and DDR2 mRNA, subsequently promoted the expression of DDR2. 36471363 CEBPA-AS1 LncRNA Rattus norvegicus Reperfusion Injury rat model Interaction(miR-340-5p/APPL1/LKB1/AMPK pathway) RNA Pull-Down//Tunel//qRT-PCR//RIP//MTT//Luciferase Report Assay We found that overexpression of CEBPA-AS1 could attenuate MCAO/IR-induced nerve damage and neuronal apoptosis in the rat model. Upon examining the molecular mechanisms, we found that CEBPA-AS1 stimulated APPL1 expression by combining with miR-340-5p, thereby regulating the APPL1/LKB1/AMPK pathway. In the rescue experiments, CEBPA-AS1 overexpression was found to attenuate OGD/R-induced cell apoptosis and MCAO/IR induced nerve damage, while miR-340-5p reversed these effects of CEBPA-AS1. Yes Knockdown of CEBPA-AS1 aggravated cell apoptosis and enhanced the production of LDH and MDA in the OGD/R cells. 34919285 CDYL CircRNA Homo sapiens Multiple Myeloma MM cells and plasma interaction[sponges miR-1180] RNA Pull-Down//Western Blot//qPCR//PCR//Cell Apoptosis Assay//IF Here, we described an important MM-related circular RNA (circRNA), circ-CDYL. It was remarkably increased in both MM cells and plasma.Circ-CDYL could absorb miR-1180 and alleviated the repression of miR-1180 on YAP, leading to increased YAP expression, ultimately triggering MM uncontrolled growth. Yes Depletion of circ-CDYL evidently stunted MM growth. 32321304 CDR1as CircRNA Homo sapiens Stomach Neoplasms GC cell Interaction(miR-876-5p/GNG7 Axis) Western Blot//qPCR//RIP//PCR//IP//Invasion Assay//IF In summary, our findings indicate that CDR1as suppresses GC metastasis through the CDR1as/miR-876-5p/GNG7 axis. Yes Here, we found that CDR1as knockdown facilitated GC cell migration and invasion while its overexpression inhibited the migration and invasion abilities of GC cells in vitro and in vivo.Moreover, epithelial-mesenchymal transition- (EMT-) associated proteins and MMP2 and MMP9 were downregulated by CDR1as. 34221006 CDR1as CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Interaction[as a sponge of miR-135b-5p] Western Blot//CCK8//qRT-PCR//MTT//PCR CDR1as expression in ovarian tissues was significantly lower in ovarian cancer patients than in patients without ovarian cancer. CDR1as, acting as a sponge of miR-135b-5p, promotes the expression of HIF1AN and therefore plays a role in tumor inhibition. Yes CDR1as overexpression inhibited the proliferation, invasion and migration of ovarian cancer cells. 31190886 Cdr1as CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cells Regulation Western Blot//ISH//qRT-PCR//FISH//PCR//IP//IF Cdr1as was significantly down-regulated in bladder cancer tissues compared with adjacent normal tissues. Cdr1as sponged multiple miRNAs in bladder cancer. Moreover, Cdr1as directly bound to miR-135a and inhibited its activity in bladder cancer. Yes Overexpression of Cdr1as inhibited the proliferation, invasion and migration of bladder cancer cells in vitro and slowed down tumour growth in vivo. 29694981 CDR1as CircRNA Homo sapiens Pancreatic Neoplasms PC tissues. Interaction(miR-432-5p/E2F3 axis) colony Formation Assay//Western Blot//Transfection//Flow Cytometry//IF//PCR//Microarray//Colony Formation Assay//Transwell Assay We found that circCDR1as was highly expressed in PC tissues. The levels of circCDR1as in PC tissues and cells were higher than those in controls. CircCDR1as promoted the migration, invasion and proliferation of PC cells in vitro and tumor growth in vivo via mediating E2F3 expression by sponging miR-432-5p. Yes CircCDR1as promoted the migration, invasion and proliferation of PC cells in vitro and tumor growth in vivo via mediating E2F3 expression by sponging miR-432-5p. 33593338 CDR1as CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues interaction[ miR-7] Flow Cytometry//PCR//Western Blot CDR1as levels was robustly increased with the development of NSCLC (P<0.001) and the NSCLC tissues harbored highest expression of CDR1as, which negatively correlated to the expression of miR-7. Mechanistically, CDR1as functioned as miR-7 sponges to up-regulate the key target genes of miR-7 including EGFR, CCNE1 and PIK3CD. Patients with high expression of CDR1as had high TNM stage (P=0.004), more lymph nodes metastasis (LNM) (P=0.021) and shorted overall survival time (OS) (P=0.0135). The CDR1as level was an independent prognostic factor for the patients with NSCLC. Yes Overexpression of CDR1as induced increased cell vitalities and growth, which could be abrogated by knockdown of CDR1as or overexpressed miR-7 to induce apoptosis and G1/S arrest. 30022841 CDR1as CircRNA Homo sapiens Cholangiocarcinoma CCA cell lines interaction[MicroRNA 641 ] colony Formation Assay//qPCR//RIP//PCR//IP//Colony Formation Assay//IF In vitro, the CDR1as level was significantly increased in CCA cell lines.In conclusion, our findings indicated that CDR1as might exert oncogenic properties, at least partially, by regulating miR-641 in CCA. CDR1as and miR-641 could be considered therapeutic targets for CCA. Yes The results showed that CDR1as promoted the cell proliferation, migration, invasion, and activation of the AKT3/mTOR pathway in CCA cells. 32423991 CDR1as CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC cells Regulation[miR-7 signals] colony Formation Assay//IHC//Western Blot//Flow Cytometry//PCR//Colony Formation Assay The CDR1as and miR-7 were overexpressed in LSCC cells to investigate its function and mechanism in vitro and in vivo.CDR1as is an oncogene that promotes LSCC progression by regulating miR-7 signals. Patients with high TNM stages, poorly differentiated tumours, lymph node metastases and poor prognosis had high CDR1as levels but low miR-7 levels. Yes Overexpression of CDR1as in vitro enhanced cell vitality, and promoted the proliferation, migration, and invasion of two LSCC cell lines (Hep2 and AMC-HN-8.) 30182381 CDKN2B-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Regulation[NF-kB signaling] qRT-PCR//Western Blot TET2 suppressed tumor growth by regulating ANRIL, and ANRIL supported tumor progress as indicated above, but its mechanism was unclear. NF-kB signaling was critical in cancer progression. To identify the relationship between NF-kB and ANRIL, we evaluated p65 protein levels in the nucleus of MG803 cells. Unlike the total protein level in the whole cell, knockdown of ANRIL resulted in a decrease of p65 protein in the nucleus (Figure 4(a)), suggesting that ANRIL could promote p65 to enter nucleus from the cytoplasm. Furthermore, NF-kB inhibitor sc75741 could inhibit migration of gastric cancer cells, and ANRIL could not further suppress migration in the presence of sc75741 (Figure 4(b)). Real-time qPCR indicated knockdown of ANRIL resulted in a decrease in the mRNA levels of NF-kB target genes (Figure 4(c)). All the above results suggested that the function of ANRIL depended on NF-kB signaling. To confirm the functions of TET2 and ANRIL in human patients, 192 gastric cancer patients were followed up, and the mRNA levels of TET2, ANRIL, and NF-kB target genes in the tumor samples were evaluated with real-time qPCR. There were 125 patients grouped to low TET2 expression and 67 patients arranged to high TET2 expression, and patients with high TET2 expression had significantly longer survival time. For analysis of the relationship between ANRIL and patient survival (Figure 5(a)), 123 patients were grouped to low ANRIL expression, and 69 patients were high ANRIL expression. On the contrary, patients with low ANRIL had a longer survival time (Figure 5(a)). In the tumor samples, expression of TET2 and ANRIL was negatively correlated (Figure 5(b)), and ANRIL was expressed positively related to NF-kB target genes p21, cIAP1, uPA, and MMP2 (Figure 5(c) to (f)). These results further indicated that ANRIL enhanced NF-kB signaling. Yes In this study, we found the long non-coding RNA ANRIL was critical for the progression of gastric cancer. Knockdown of ANRIL (also known as CDKN2B-AS) with shRNA increased apoptosis, inhibited tumor growth, and suppressed migration of cancer cells. TET2 (Tet Methylcytosine Dioxygenase 2), a methylcytosine dioxygenase suppressed ANRIL function and prevented cancer progression. 31242038 CERNA2 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tumor tissues and adjacent normal tissues Interaction[let-7b;CDK6 ] CCK8//qRT-PCR//Western Blot The results revealed increased expression levels of HOST2 in tumor tissues from patients with TNBC.The silencing of HOST2 induced cell proliferation inhibition and cell cycle redistribution in MDA‑MB‑231 and MDA‑MB‑468 TNBC cells. In these two cell lines, HOST2 silencing caused a decrease in the phosphorylation of RB1 and CDK6, which was observed at the mRNA and protein levels. However, the silencing of CDK6 did not alter the expression of HOST2. It was hypothesized and confirmed that let‑7b, a previously reported target miRNA of HOST2, was able to directly bind to the 3'UTR of CDK6 and repress its expression. The expression of let‑7b was negatively correlated with the expression of HOST2 and CDK6 in tumor tissues. Overall, the data suggested that lncRNA HOST2 acts as an oncogene in TNBC via the Expression[Expression[up-expression]-expression]regulation of CDK6. Yes The silencing of HOST2 induced cell proliferation inhibition and cell cycle redistribution in MDA‑MB‑231 and MDA‑MB‑468 TNBC cells. 30483747 CERNA2 LncRNA Homo sapiens Triple Negative Breast Neoplasms BC tissues and cell lines Expression[highly expressed] Western Blot//ISH//qRT-PCR//RIP//FISH//MTT//Colony Formation Assay//Transwell Assay The results showed that HOST2 was up-regulated in BC tissues and cell lines.HOST2 could function as a oncogene and promoted STAT3-mediated proliferation and migration through acting as a competing endogenous RNA, which might act as a potential biomarker for TNBC patients. Clinical outcome analysis demonstrated that high expression of HOST2 was associated with poor prognosis of TNBC patients. Yes Functional experiments illustrated that knockdown of HOST2 significantly suppressed TNBC cell proliferation and migration. 32248842 CDK6-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML cells Regulation qRT-PCR//Colony Formation Assay CDK6-AS1 silencing triggered hematopoietic commitment in healthy CD34+ cells, whereas in AML cells the pathological undifferentiated state was rescued. Yes By CDK6-AS1 silencing in vitro, AML mitochondrial mass decreased with augmented pharmacological sensitivity to mitochondria-targeting drugs. In vivo, the combination of tigecycline and cytarabine reduced leukemia progression in the AML-PDX model with high CDK6-AS1 levels, supporting the concept of a mitochondrial vulnerability. 34816103 CERNA2 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Interaction [ Bcl-2/Bax] qRT-PCR//MTT The expression levels of lnc-HOST2 in osteosarcoma tissues were significantly higher than those in corresponding noncancerous bone tissues (p < 0.01). Notably, we confirmed that up-regulation of lnc-HOST2 led to Bcl-2 downregulation and Bax upregulation in osteosarcoma cells. Statistical assay indicated that the expression level of lnc-HOST2 was positively correlated with tumor stage (p = 0.003) and distant metastasis (p = 0.000). Furthermore, Kaplan-Meier analysis suggested that patients with high lnc-HOST2 showed poorer overall survival than those with low lnc-HOST2 (p = 0.000). The univariate and multivariate analysis further revealed that lnc-HOST2 expression was an independent prognostic factor for overall survival. Yes Then, functionally, down-regulation of lnc-HOST2 suppressed proliferation and induced cell apoptosis in osteosarcoma cells. 29509239 CHAER1 LncRNA Homo sapiens Atherosclerosis blood Regulation[mTOR signaling] CCK8//qRT-PCR//RIP//ChIP We found that the Chaer was highly expressed in serum samples from 28 patients with atherosclerosis, compared with 28 healthy volunteers. Mechanistically, Chaer interacts with Polycomb Repressor Complex 2 (PRC2) through inhibiting histone H3 lysine 27 methylation. Further, this interaction is induced upon mTOR signaling pathway. Yes Through loss- and gain-of-function approaches, we showed that Chaer promotes cell proliferation and induces apoptosis in vitro. 31539156 cFUT8 LncRNA Homo sapiens Liver Neoplasms HCC tissue Interaction(miR-548c/FUT8 axis) qRT-PCR The results showed that cFUT8 and miR-548c were predominantly co-localized in the HCC cell cytoplasm (Fig. 1o). To determine whether endogenous cFUT8 may serve as a binding platform for miR-548c, we conducted RNA immunoprecipitation (RIP) in HepG2 and Huh7 cells. Strikingly, endogenous miR-548c binding to cFUT8 increased more than 30-fold (Supplementary Fig. S5a). Similarly, endogenous cFUT8, pulled down by miR-548c, was also significantly increased at almost 40-fold in these cells (Supplementary Fig. S5b). With similar processing, expression of FUT8 was significantly enhanced when miR-548c was present (Supplementary Fig. S5c). However, this enrichment was attenuated when coupled with cFUT8 (Fig. 1p). When the free miR-548c level was increased, we identified that FUT8 expression was significantly inhibited at both the mRNA and protein levels (Supplementary Fig. S5d, e). Meanwhile, we performed a dual-luciferase reporter assay to assess whether FUT8 is a direct target of miR-548c. As shown in Fig. 1q, the luciferase activity in both HepG2 and Huh7 cells was significantly reduced by miR-548c mimic transfection, compared with the negative control. Yes Similarly, endogenous cFUT8, pulled down by miR-548c, was also significantly increased at almost 40-fold in these cells (Supplementary Fig. S5b). 33500381 Cfast LncRNA Mus musculus Cardiac Fibrosis heart tissues interaction[COTL1 ,TRAP1 ,TGF-β signaling ] qRT-PCR//RNA Pull-Down//RIP//Western Blot Using unbiased transcriptome profiling in a mouse model of myocardial infarction (MI), we identified a cardiac fibroblast-enriched lncRNA (AK048087) named cardiac fibroblast-associated transcript (Cfast), which is significantly elevated after MI.Mechanistically, Cfast competitively inhibits the COTL1 interaction with TRAP1 (transforming growth factor-β receptor-associated protein 1), which enhances TGF-β signaling by augmenting SMAD2/SMAD4 complex formation. Yes Silencing Cfast expression by small interfering RNAs (siRNAs) or lentiviral short hairpin RNAs (shRNAs) resulted in suppression of fibrosis-related gene expression and transdifferentiation of myofibroblasts into cardiac fibroblasts. Depletion of Cfast by lentiviral shRNAs in mouse hearts significantly attenuated cardiac fibrosis induced by MI or isoproterenol-infusion. Importantly, inhibition of Cfast ameliorated cardiac function following cardiac injury. 33473324 CFAR LncRNA Homo sapiens Cardiac Fibrosis cardiac fibroblasts and tissues Interaction(miR-449a-5p/LOXL3/mTOR axis) Other CFAR was upregulated in cardiac fibrosis and its knockdown attenuated the expression of fibrotic marker genes and the proliferation of cardiac fibroblasts, thereby ameliorating cardiac fibrosis. Moreover, CFAR acted as a ceRNA sponge for miR-449a-5p and derepressed the expression of LOXL3, which we experimentally established as a target gene of miR-449a-5p. In contrast to CFAR, miR-449a-5p was found to be significantly downregulated in cardiac fibrosis, and artificial knockdown of miR-449a-5p exacerbated fibrogenesis, whereas overexpression of miR-449a-5p impeded fibrogenesis. Furthermore, we found that LOXL3 mimicked the fibrotic factor TGF-β1 to promote cardiac fibrosis by activating mTOR. Yes CFAR was upregulated in cardiac fibrosis and its knockdown attenuated the expression of fibrotic marker genes and the proliferation of cardiac fibroblasts, thereby ameliorating cardiac fibrosis. 36334219 CES1P1 LncRNA Homo sapiens Diabetic Nephropathies C57BL/6 mice, HUVECs Interaction(miR-214-3p/ IL-17) qRT-PCR//Luciferase Report Assay//Western Blot In vitro experiments using high glucose (HG) stimulation of HUVECs cell revealed increased expression of lncRNA-CES1P1, decreased expression of miR-214-3p, and increased expression of the inflammatory factors IL-17, IκB, NF-κB, and IL-6. Luciferase reporter assays showed direct targets of miR-214-3p interaction with lncRNA-CES1P1 and IL-17. Yes Exogenous knockdown of lncRNA-CES1P1 expression decreased renal inflammatory infiltration. 35834955 CERS6-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction(miR-567) CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The expression of lncRNA CERS6-AS1 was elevated in gastric cancer tissues and cells. Yes In addition, the ability of gastric cancer cells to proliferate, migrate and invade could be reduced by knockdown CERS6-AS1. After CERS6-AS1 knockdown, the expression level of miR-567 in gastric cancer tissues decreased, while the expression level of miR-567 increased. 34852705 CERS6-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction[binding to IGF2BP3] RNA Pull-Down//Western Blot//Tunel//CCK8//qRT-PCR//FISH//RIP//Colony Formation Assay//EdU Staining//Transwell Assay In this study, it was discovered that CERS6-AS1 was overexpressed in BC tissues and cells. Taken together, these evidences suggested that CERS6-AS1 promoted the progression of BC by binding to IGF2BP3 and thus enhancing the stability of CERS6 mRNA, providing a new underlying therapeutic target for BC to improve prognosis. Yes CERS6-AS1 accelerated cell proliferation and suppressed cell apoptosis in BC. 31701672 CERS6-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues regulation[miR-125a-5p,BAP1 ] qRT-PCR Then we found CERS6-AS1 was upregulated in BC tissues.Our results indicated CERS6-AS1 promote BC cell proliferation and inhibit cell apoptosis via sponging miR-125a-5p to upregulate BAP1 expression. Yes Experimental results of tumor growth in nude mice show that CERS6-AS1 promotes tumor growth. 32808708 CERS6-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(CERS6-AS1/miR-16-5p/UBE2C axis) In Vivo Experiment//Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay It was found that CERS6-AS1 and UBE2C were meaningfully upregulated in BC, and knockdown of both CERS6-AS1 and UBE2C inhibited the BC cell proliferation and migration, whereas induced apoptosis. Mechanistically, CERS6-AS1 could facilitate BC progression by sponging miR-16-5p for upregulation of the UBE2C expression. Yes It was found that CERS6-AS1 and UBE2C were meaningfully upregulated in BC, and knockdown of both CERS6-AS1 and UBE2C inhibited the BC cell proliferation and migration, whereas induced apoptosis. 36136991 CERS6-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Interaction(microRNA-1202 Axis) qRT-PCR High expression of IGF2BP3, CERS6-AS1 and GDPD5, and low expression of miR-1202 levels were witnessed in lung cancer tissues. IGF2BP3 positively modulated CERS6-AS1 to regulate miR-1202-targeted GDPD5. Inhibition of CERS6-AS1 or promotion of miR-1202 depressed lung cancer aggravation. CERS6-AS1 silencing or miR-1202 overexpression reversed the impacts induced by IGF2BP3 on lung cancer. Yes Suppression of IGF2BP3 restrained lung cancer progression. 35702784 CERS6-AS1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cells Interaction(miR-15b-5p/SPTBN2) Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay We found that CERS6-AS1 and SPTBN2 were highly expressed in colorectal cancer tissues and cells. Moreover, SPTBN2 levels were positively regulated by CERS6-AS1 and negatively regulated by miR-15b-5p in colorectal cancer cells. Rescue assays revealed that SPTBN2 reversed the inhibitory effect of CERS6-AS1 deficiency on the malignant behaviors of colorectal cancer cells. Overall, the lncRNA CERS6-AS1 facilitates malignant phenotypes of colorectal cancer cells by targeting miR-15b-5p to upregulate SPTBN2. Yes CERS6-AS1 depletion inhibited cell viability, proliferation, migration, and invasion; the epithelial-mesenchymal transition process and stemness. It suppressed xenograft tumor growth in colorectal cancer. 35146902 CERS6-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary papillary thyroid cancer tissues and cells Interaction(miR-497-5p/LASP1 Axis) qRT-PCR//RNA Pull-Down//RIP High level of CERS6-AS1 and LASP1 was detected in papillary thyroid cancer tissues and cells and predicted poor prognosis. In contrast, miR-497-5p was decreased in papillary thyroid cancer tissues and cells, which was positively correlated with prognosis. LASP1 was modulated by CERS6-AS1 through sponging miR-497-5p. Up-regulation of LASP1 or silencing miR-497-5p could weaken the effect of CERS6-AS1 on papillary thyroid cancer cells. High level of CERS6-AS1 and LASP1 was detected in papillary thyroid cancer tissues and cells and predicted poor prognosis. In contrast, miR-497-5p was decreased in papillary thyroid cancer tissues and cells, which was positively correlated with prognosis. Yes Silencing CERS6-AS1 suppressed cell viability and increased ferroptosis in papillary thyroid cancer. Silencing CERS6-AS1 restrained the growth of xenografted tumors. 35777805 CERS6-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation(MDM2/p53 signaling pathway) qRT-PCR CERS6-AS1 was highly expressed in HCC tissues and cell lines.Bioinformatics analyses combining with PCR analysis identified miR-30b-3p as the potential target of CERS6-AS1, and MDM2 mRNA was verified as the target of miR-30b-3p. The expression of miR-30b-3p was negatively correlated with CERS6-AS1, whereas MDM2 was positively associated with CERS6-AS1. Mechanistic studies showed that CERS6-AS1 may sponge miR-30b-3p to elevate MDM2, thus promoting the MDM2-mediated ubiquitin-dependent degradation of the p53 tumor suppressor. MDM2 overexpression or miR-30b-3p inhibitors blocked the inhibitory effect of CERS6-AS1 knockdown on proliferation, migration and glycolysis. Upregulated CERS6-AS1 expression was remarkably correlated with poor prognosis of HCC patients. Yes High CERS6-AS1 expression facilitated cell growth, invasion and glycolysis of HCC cells. CERS6-AS1 depletion reduced tumor formation in the in vivo mouse model. 35927226 CERS6-AS1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues and cell lines Interaction(microRNA-15a-5p/FGFR1 axis) qRT-PCR//RIP CERS6-AS1 expression was evidently increased in PDAC tissues and cell lines. Mechanistically, CERS6-AS1 could competitively bind to microRNA-15a-5p (miR-15a-5p) and effectively work as a molecular sponge in PDAC cells, resulting in the upregulation of fibroblast growth factor receptor 1 (FGFR1), a direct target of miR-15a-5p. Rescue experiments revealed that miR-15a-5p downregulation or FGFR1 restoration rescued the effects of CERS6-AS1 knockdown on the behaviors of PDAC cells. Patients with PDAC having high CERS6-AS1 expression had shorter overall survival periods than those having low CERS6-AS1 expression. Yes Functionally, the knockdown of CERS6-AS1 attenuated the proliferation, migration, and invasion and stimulated apoptosis of PDAC cells in vitro. Additionally, CERS6-AS1 depletion decreased PDAC tumor growth in vivo. 33581689 CERS6-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines Interaction(miR-217/YWHAG/RAF1 signaling axis) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//RIP//FISH//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay//IF We found that lncRNA CERS6-AS1 was highly expressed in PC tissues and cells. Additionally, high expression of CERS6-AS1 was obviously associated with poor prognosis. high expression of CERS6-AS1 was obviously associated with poor prognosis. Yes Functional assays demonstrated that CERS6-AS1 downregulation significantly inhibited PC cell growth and migration. Moreover, CERS6-AS1 exerted as a molecular sponge for miR-217-5p (miR-217), and miR-217 was confirmed as a potential target of CERS6-AS1. 34168120 CERS6-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC cells and tissues Interaction(miR-195-5p/WIPI2 axis) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis As shown by RT-qPCR, CERS6-AS1 was significantly upregulated in PC cells and tissues.Mechanistically, CERS6-AS1 interacted with miR-195-5p to elevate the expression level of the WD repeat domain phosphoinositide interacting 2 (WIPI2), which is a downstream target gene of miR-195-5p in PC. Moreover, miR-195-5p expression was negatively associated with CERS6-AS1 expression (or WIPI2 expression) in PC tissues. Rescue assays revealed that WIPI2 overexpression rescued the effects of CERS6-AS1 deficiency on cell viability, proliferation, and apoptosis. Yes Silencing CERS6-AS1 suppressed PC cell viability and proliferation while enhancing cell apoptosis according to colony formation assays, EdU assays, and flow cytometry analyses. 35199935 CERS6-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissue and cell lines Interaction(miR-16-5p) Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay Compared with the adjacent tissues, the relative level of CERS6-AS1 in prostate cancer tissue was increased (P < 0.05), and the relative level of miR-16-5p was decreased (P < 0.05). Compared with RWPE-1 cells, the relative level of CERS6-AS1 in DU145 cells was increased (P < 0.05), and the relative level of miR-16-5p was decreased (P < 0.05). Yes Compared with the control group and the si-NC group, the HMGA2 protein expression, the colony formation number, and the scratch healing rate of DU145 cells in the si-CERS6-AS1 group and the miR-16-5p mimic group were reduced (P < 0.05), and the relative level of miR-16-5p and the proliferation inhibition rate and apoptosis were increased (P < 0.05). miR-16-5p is specifically bound to CERS6-AS1 and HMGA2, respectively. Compared with the si-CERS6-AS1 group, the HMGA2 protein expression, the colony formation number, and the scratch healing rate of DU145 cells in the si-CERS6-AS1+miR-16-5p inhibitor group were increased (P < 0.05), and the cell proliferation inhibition rate and apoptosis rate were reduced (P < 0.05). 35706508 CERS6-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction(miR-6838-5p/FOXP2 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Here, we found that the expression of CERS6-AS1 was upregulated in CC tissues and cell lines compared with adjacent tissues and normal human cervical epithelial cells.CERS6-AS1 was verified as a sponge of miR-6838-5p by RNA pull-down and luciferase reporter gene assays.Functional investigations revealed that CERS6-AS1 knockdown inhibited proliferation and invasion, and promoted apoptosis in CC cells, which was reversed by miR-6838-5p inhibitor. Furthermore, forkhead box P2 (FOXP2) was identified as a target for miR-6838-5p, and overexpression of miR-6838-5p decreased the expression level of FOXP2. Yes CERS6-AS1 overexpression promoted proliferation and invasion, and inhibited apoptosis in CC cells, while silencing of CERS6-AS1 led to the opposite results.Besides, CERS6-AS1 was able to sponge miR-6838-5p to accelerate CC cell proliferation and invasion and inhibited cell apoptosis through upregulating FOXP2 expression. 36444938 CERNA2 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Expression[highly expressed] qRT-PCR//MTT In this study, we found that CERNA2 expression was significantly increased in GC tissues and cell lines compared to adjacent non-cancerous tissues and normal gastric epithelial cells, respectively. High levels of CERNA2 were correlated with poor clinical parameters and an unfavorable prognosis of GC patients. Yes Moreover, silencing CERNA2 expression effectively inhibited gastric cancer cell growth and induced cell apoptosis in vitro. Collectively, our results demonstrate that the up-regulation of CERNA2 is associated with malignant status and poor prognosis in patients with GC, and silencing CERNA2 expression inhibits gastric cancer cell growth and promotes cell apoptosis, suggesting CERNA2 could possibly be a promising diagnostic and treatment target for GC. 31949664 CDKN2B-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and adjacent normal tissues Interaction(miR-122-5p/STK39 axis) Western Blot//Colony Formation Assay//qRT-PCR//Luciferase Report Assay//IHC As for the results, there is a relative rich expression of CDKN2B-AS1 in breast cancer tissues compared with the corresponding adjacent normal tissues. Compared with the human breast epithelial cell line, the abundant expression of CDKN2B-AS1 in breast cancer cells were revealed as well. In mechanism, CDKN2B-AS1 sponged the miR-122-5p to regulate STK39 expression. Furthermore, the inhibition effect with sh-CDKN2B-AS1 on breast cancer cells was alleviated by miR-122-5p inhibitor. Yes Then, knockdown CDKN2B-AS1 inhibited the malignant biological behaviors of MCF7 and T47D cells. 34374638 CDKN2B-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell lines regulation[miR-378b/NR2C2] qRT-PCR//Transwell Assay//Western Blot The expression of lncRNA CDKN2B-AS1 was significantly upregulated in lung cancer tissues and cell lines. Taken together, our results comprehensively analyzed the function of CDKN2B-AS1 in lung cancer and provided a possible mechanism that CDKN2B-AS1 facilitates lung cancer development by regulating miR-378b and NR2C2. Yes Overexpression of CDKN2B-AS1 promoted cell proliferation, invasion and reduced cell apoptosis. Knockdown of CDKN2B-AS1 inhibited cell proliferation, invasion and increased cell apoptosis. 33116641 CDKN2B-AS1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-378b/CAPRIN2 axis) RNA Pull-Down//Western Blot//Transfection//Migration Assay//Proliferation Assay//qRT-PCR//RIP//migration assay//PCR//Cell Proliferation Assay//IP//IF We found that the expression of CDKN2B-AS1 and CAPRIN2 was upregulated in CRC and they were linked to the poor differentiation and distant metastasis in CRC patients. Notably, the results of Starbase 2.0 database analysis and in vitro experiments demonstrated that CDKN2B-AS1 could interact with miR-378b and regulate its expression. Furthermore, CAPRIN2 acted as a downstream target of CDKN2B-AS1/miR-378b that involved in modulating β-catenin expression in CRC cells. We found that the expression of CDKN2B-AS1 and CAPRIN2 was upregulated in CRC and they were linked to the poor differentiation and distant metastasis in CRC patients. Yes CDKN2B-AS1 knockdown attenuated while CDKN2B-AS1 overexpression promoted CRC cell proliferation and migration. 34511033 CDKN2B-AS1 LncRNA Homo sapiens Osteoarthritis cell lines Regulation[ miR-122-5p/DUSP4 axis] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP We indicated that the expression of ANRIL was significantly improved in OAS compared to NS. Moreover, ANRIL could regulate the proliferation and apoptosis of OAS via miR-122-5p/DUSP4 axis. Yes The expression of ANRIL was decreased and the cell proliferation was reduced in OAS after transfected with siRNA. 31799639 CDKN2B-AS1 LncRNA Homo sapiens Thyroid Neoplasms CSCs-derived exosomal Interaction(miR-122-5p/P4HA1 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis//Transwell Assay Exosomal CDKN2B-AS1 up-regulated P4HA1 expression through miR-122-5p. CDKN2B-AS1 and P4HA1 expressions were up-regulated, and miR-122-5p expression was down-regulated in thyroid cancer. MiR-122-5p inhibitor reversed the function of exosomal CDKN2B-AS1, while P4HA1 silencing attenuated the effect of miR-122-5p inhibitor. Exosomal CDKN2B-AS1 affected the growth and metastasis of thyroid cancer through the miR-122-5p/P4HA1 axis. Yes Silent CDKN2B-AS1 reduced cell viability and stemness. CDKN2B-AS1 was found to be abundant in CSCs and CSCs-derived exosomes. Exosomal CDKN2B-AS1 silencing could transfer to thyroid cancer cells to elevate E-cadherin level, and diminish P4HA1, N-cadherin and Vimentin levels, thus impeding cell migration and invasion. 36582605 CDKN2B-AS1 LncRNA Homo sapiens Multiple Myeloma multiple myeloma tissues regulation[HIF-1α,miR-411-3p] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//BrdU In this study, compared with normal tissues from healthy donors, lncRNA ANRIL and HIF-1α expressions were up-regulated in tumor tissues from multiple myeloma patients. Our results demonstrate that lncRNA ANRIL mediated by miR-411-3p promotes the malignant proliferation and tumor stem cell like property of multiple myeloma through regulating HIF-1α. Yes Further transfection experiments showed that knockdown of ANRIL or overexpression of miR-411-3p significantly inhibited cell proliferation, tumor formation ability and tumor stem cell like property, promoted cell apoptosis in vitro. 32961145 CDKN2B-AS1 LncRNA Homo sapiens Multiple Myeloma MM patients and cell lines Interaction(EZH2) In Vivo Experiment//Western Blot//BrdU//Flow Cytometry//qRT-PCR//RIP//RNA-seq//Cell Proliferation Assay//ChIP We found that ANRIL was upregulated in MM patients and cell lines, and associated with advanced international staging system (ISS) stage and poor overall survival. Our results indicated that ANRIL exerted oncogenic functions and conferred chemoresistance of MM cells by EZH2-mediated epigenetically silencing of PTEN. We found that ANRIL was upregulated in MM patients and cell lines, and associated with advanced international staging system (ISS) stage and poor overall survival. Yes Enforced ANRIL expression promoted proliferation and tumor xenograft growth of MM cells, while knockdown of ANRIL exhibited opposite effects. Moreover, ANRIL overexpression increased the half-maximal inhibitory concentration (IC50) of bortezomib and reduced bortezomib-induced apoptosis in MM cells. 34034498 CDKN2B-AS1 LncRNA Homo sapiens Idiopathic Pulmonary Fibrosis TGF-β-treated cells and BLM-treated mice Interaction( CDKN2B-AS1/miR-199a-5p/SESN2 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay We found that the expression of CDKN2B-AS1 was decreased in TGF-β-treated cells and BLM-treated mice. Mechanistically, CDKN2B-AS1 acts as a miR-199a-5p sponge to regulate SESN2 expression. Our results indicate the importance of the CDKN2B-AS1/miR-199a-5p/SESN2 axis. Yes Overexpression of CDKN2B-AS1 inhibited cell proliferation and migration, promoted apoptosis, decreased the expression of fibrosis-related proteins and promoted autophagy. In addition, overexpression of CDKN2B-AS1 alleviated pulmonary fibrosis in BLM-treated mice. 35291918 CDKN2B-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues Regulation[miR-181a/Snai2 axis] CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay ANRIL was up-regulated while miR-181a was down-regulated in LSCC tissues.Dual luciferase reporter assay showed ANRIL could directly sponge miR-181a to counteract its suppression on Snai2, serving as a positive regulator of Snai2. Either knockdown of ANRIL or overexpression of miR-181a significantly inhibited the proliferation, clonogenicity, invasion, migration and epithelial mesenchymal transformation (EMT), as well as promoted the apoptosis of LSCC cells, and knockdown of miR-181a reversed the effects. Yes knockdown of ANRIL or overexpression of miR-181a significantly inhibited the proliferation, clonogenicity, invasion, migration and epithelial mesenchymal transformation (EMT), as well as promoted the apoptosis of LSCC cells, and knockdown of miR-181a reversed the effects. 31667207 CDKN2B-AS1 CircRNA Homo sapiens Endometrial Neoplasms EC tissues and cell lines Expression [highly expressed] In Vivo Experiment//cell invasion assay//Transfection//FISH//qRT-PCR//Cell Proliferation Assay Real-time quantitative polymerase chain reaction showed that CDKN2B-AS1 was significantly overexpressed in EC, whereas its knockdown inhibited the proliferation and invasion of EC cells and the in vivo growth of transplanted tumors in nude mice. Yes Real-time quantitative polymerase chain reaction showed that CDKN2B-AS1 was significantly overexpressed in EC, whereas its knockdown inhibited the proliferation and invasion of EC cells and the in vivo growth of transplanted tumors in nude mice. 34712660 CDKN2B-AS1 LncRNA Homo sapiens acute myocardial infarction cell lines Regulation[miR-7-5p/SIRT1 axis] Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay ANRIL expression was dramatically enhanced in hypoxia-injured H9c2 cells, and silencing ANRIL aggravated hypoxia-induced H9c2 cell injury. Our findings disclosed that ANRIL plays a protective part in hypoxia-induced H9c2 cell injury via modulating the miR-7-5p/SIRT1 axis, suggesting the great potential of ANRIL as a protective target for AMI. Yes ANRIL expression was dramatically enhanced in hypoxia-injured H9c2 cells, and silencing ANRIL aggravated hypoxia-induced H9c2 cell injury. 31264206 CDKN2B-AS1 LncRNA Homo sapiens Liver Neoplasms LC cases Interaction(miR-199a-5p) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay CDKN2B-AS1 in LC cases presented high expression and dropped after therapy (P < 0.05), and the opposite situation of miR-199a-5p was found in the LC cases (P < 0.05). The DLR assay revealed suppressed fluorescence activity of CDKN2B-AS1-WT by miR-199a-5p (P < 0.05). Moreover, according to the rescue assay, the impacts of silencing CDKN2B-AS1 on LC cells could be completely offset by silencing miR-199a-5p (P < 0.05). According to the clone formation and WB assay, the growth and autophagy of LC cells were under the regulation of CDKN2B-AS1 targeting miR-199a-5p (P < 0.05). Yes In vitro assays, after silencing of CDKN2B-AS1 and upregulation of miR-199a-5p, LC cells presented weaker viability, invasion and migration activities, and stronger apoptotic activity (all P < 0.05). 36081669 CDKN2B-AS1 LncRNA Homo sapiens Rhinitis, Allergic AR cell model Interaction(miR-16-5p/TLR4 Axis) qRT-PCR//Luciferase Report Assay//RIP//Western Blot Moreover, knockdown of ANRIL reversed the effect of AR on autophagy-related protein and tight junction proteins MiR-16-5p was found to be bound with ANRIL and miR-16-5p inhibitor could reverse ANRIL knockdown-induced downregulation of autophagy-related proteins and epithelial barrier dysfunction. In addition, miR-16-5p directly targeted TLR4. Furthermore, knockdown of ANRIL reversed miR-16-5p and TLR4 expression, autophagy level, and tight junction protein levels in nasal mucosa of AR mice. Yes Moreover, knockdown of ANRIL reversed the effect of AR on autophagy-related protein and tight junction proteins MiR-16-5p was found to be bound with ANRIL and miR-16-5p inhibitor could reverse ANRIL knockdown-induced downregulation of autophagy-related proteins and epithelial barrier dysfunction. In addition, miR-16-5p directly targeted TLR4. Furthermore, knockdown of ANRIL reversed miR-16-5p and TLR4 expression, autophagy level, and tight junction protein levels in nasal mucosa of AR mice. 35404176 CDKN2B-AS1 LncRNA Homo sapiens Diabetic Nephropathies SV40-MES13 cells Regulation(Wnt/β-catenin and MEK/ERK pathways ) qRT-PCR//Transfection Lnc-ANRIL expression was significantly higher in HG-treated SV40-MES13 cells compared with normal glucose-treated SV40-MES13 cells and osmotic control-treated SV40-MES13 cells. Lnc-ANRIL knock-down suppressed cell proliferation and promoted cell apoptosis in HG-treated SV40-MES13 cells. As for fibrosis, lnc-ANRIL knock-down reduced fibronectin and collagen I expressions in HG-treated SV40-MES13 cells. Besides, the expressions of supernatant tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-1β, IL-6, IL-8 and IL-18 were reduced in Sh-ANRIL group compared with Sh-NC group. Furthermore, Wnt3, β-catenin, p-MEK1 and p-ERK1 expressions were suppressed in Sh-ANRIL group compared with Sh-NC group, which suggested that lnc-ANRIL knock-down inhibited Wnt/β-catenin and MEK/ERK pathways in HG-treated SV40-MES13 cells. Yes Lnc-ANRIL knock-down suppressed cell proliferation and promoted cell apoptosis in HG-treated SV40-MES13 cells. As for fibrosis, lnc-ANRIL knock-down reduced fibronectin and collagen I expressions in HG-treated SV40-MES13 cells. Besides, the expressions of supernatant tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-1β, IL-6, IL-8 and IL-18 were reduced in Sh-ANRIL group compared with Sh-NC group. Furthermore, Wnt3, β-catenin, p-MEK1 and p-ERK1 expressions were suppressed in Sh-ANRIL group compared with Sh-NC group, which suggested that lnc-ANRIL knock-down inhibited Wnt/β-catenin and MEK/ERK pathways in HG-treated SV40-MES13 cells. 32726814 CDKN2B-AS1 LncRNA Homo sapiens endometriosis of ovary endometrial stromal cells and Ishikawa cells Interaction(miR-424-5p) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay The relative expression level of CDKN2B-AS1 was up-regulated in eutopic and ectopic endometria. In endometrial stromal cells and Ishikawa cells, CDKN2B-AS1 overexpression promoted cellular proliferation and invasion, and increased the protein expression of vimentin but decreased the expression of E-cadherin. miR-424-5p was confirmed the target of CDKN2B-AS1 through bioinformatics tools and luciferase reporter assays. In addition, the enhanced effect of cellular phenotype of CDKN2B-AS1 overexpression was significantly attenuated by miR-424-5p overexpression. Furthermore, miR-424-5p was able to directly target AKT3 through luciferase reporter assay. Mechanistically, CDKN2B-AS1 acts as a ceRNA by sponging miR-424-5p and targets AKT3. Yes In endometrial stromal cells and Ishikawa cells, CDKN2B-AS1 overexpression promoted cellular proliferation and invasion, and increased the protein expression of vimentin but decreased the expression of E-cadherin.Furthermore, miR-424-5p was able to directly target AKT3 through luciferase reporter assay. 33820740 CDKN2B-AS1 LncRNA Homo sapiens laryngeal squamous cell carcinoma LSCC tissues Interaction[miR-497/CDK6 Pathway] qRT-PCR//Luciferase Report Assay The expression of CDKN2B-AS1 was significantly higher in LSCC tissues than in adjacent normal tissues. Mechanically, CDKN2B functions as an oncogenic lncRNA in LSCC via regulating miR-497/CDK6 axis. Higher CDKN2B-AS1 was closely associated with lymph node metastasis and advanced clinical stage. Yes Moreover, CDKN2B-AS1 knockdown by siRNA significantly inhibited the proliferation, induced cell apoptosis, and suppressed migration and invasion in LSCC cells. 31754305 CDKN2B-AS1 LncRNA Homo sapiens laryngeal squamous cell carcinoma LSCC tissues regulation[CDKN2B-AS1/miR-324-5p/ROCK1 axis ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay CDKN2B-AS1 was upregulated in LSCC tissues, and the upregulation of CDKN2B-AS1 was correlated with overall survival, advanced clinical stage, and lymph node metastasis. The upregulation of CDKN2B-AS1 was correlated with overall survival, advanced clinical stage, and lymph node metastasis and promoted LSCC cell growth via miR-324-5p/ROCK1 axis. CDKN2B-AS1 was upregulated in LSCC tissues, and the upregulation of CDKN2B-AS1 was correlated with overall survival, advanced clinical stage, and lymph node metastasis. Yes In AMC-HN-8 cells, the knockdown of CDKN2B-AS1 by siRNA inhibited cell viability, blocked cell cycle in G1 phase, and increased the expression levels of cyclin-dependent kinase inhibitor 1A (p21), cleaved caspase3, and cleaved PPoly (ADP-Ribose) polymerase 1. 31960744 CDKN2B-AS1 LncRNA Homo sapiens Burkitt Lymphoma regulation[TGF-β1 signaling pathway] qRT-PCR In conclusion, the findings of the present study suggested that the knockdown of ANRIL may inhibit cell proliferation and promote cell apoptosis in BL by regulating the TGF?β1 signaling pathway, which may provide a novel target for the treatment of BL. Yes The results revealed that ANRIL silencing inhibited the proliferation and promoted the apoptosis of BL cells. 33325535 CDKN2B-AS1 LncRNA Homo sapiens T-cell acute lymphoblastic leukemia blood regulation[LncRNA ANRIL/miR-7-5p/TCF4 axis ] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay ANRIL was significantly up-regulated in T-ALL samples. LncRNA ANRIL can modulate malignant phenotypes of T-ALL cells, possibly by regulating miR-7-5p/TCF4 axis, and it serves as a potential therapeutic target for T-ALL. Yes Its knockdown markedly inhibited viability, migration and invasion of T-ALL cells, but its overexpression exerted the opposite effects. 32714094 CDKN2B-AS1 LncRNA Homo sapiens clear cell renal cell carcinoma KIRC tissues Interaction(IGF2BP3/CDKN2B-AS1/NUF2 axis) In Vivo Experiment//IHC//Western Blot//Transwell Assay//Wound Healing Assay//Colony Formation Assay//qRT-PCR//RIP//ChIP-seq//ChIP Here, according to the integrated analysis of RNA sequencing and survival data in TCGA-KIRC datasets, cyclin-dependent kinase inhibitor 2B antisense lncRNA (CDKN2B-AS1) was discovered to be the most upregulated among the 14 lncRNAs that were significantly overexpressed in KIRC and related to shorter survival. Thus, we conclude that the stabilization of CDKN2B-AS1 by IGF2BP3 drives the malignancy of KIRC through epigenetically activating NUF2 transcription and that the IGF2BP3/CDKN2B-AS1/NUF2 axis may be an ideal prognostic and diagnostic biomarker and therapeutic target for KIRC. Here, according to the integrated analysis of RNA sequencing and survival data in TCGA-KIRC datasets, cyclin-dependent kinase inhibitor 2B antisense lncRNA (CDKN2B-AS1) was discovered to be the most upregulated among the 14 lncRNAs that were significantly overexpressed in KIRC and related to shorter survival. Yes Functionally, CDKN2B-AS1 depletion suppressed cell proliferation, migration, and invasion both in vitro and in vivo. 33608495 CDKN2B-AS1 LncRNA Homo sapiens Renal Insufficiency, Chronic plasma of patients with CKD Interaction(EZH2/BDNF ) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Transfection//qRT-PCR//RIP//FISH//ELISA//IHC//IF In this study, we found that the circulating ANRIL level was increased and correlated with vascular endothelial dysfunction in patients with CKD, also negatively correlated with plasma brain-derived neurotrophic factor (BDNF) concentration. We constructed the ANRIL knockout mice model, and found that ANRIL deficiency reversed the abnormal expression of BDNF, along with endothelial nitric oxide synthase (eNOS), vascular adhesion molecule 1 (VCAM-1) and Von Willebrand factor (vWF). To explore the specific mechanism, RNA pull-down and RNA-binding protein immunoprecipitation (RIP) were used to explore the binding of ANRIL to histone methyltransferase Enhancer of zeste homolog 2 (EZH2). Further experiments found increased EZH2 and histone H3 lysine 27 trimethylation (H3K27me3) levels at the BDNF promoter region. Yes We constructed the ANRIL knockout mice model, and found that ANRIL deficiency reversed the abnormal expression of BDNF, along with endothelial nitric oxide synthase (eNOS), vascular adhesion molecule 1 (VCAM-1) and Von Willebrand factor (vWF). Meanwhile, mitochondrial dynamics-related proteins, Dynamin-related protein 1 (Drp1) and mitofusins (Mfn2) level were also recovered. In addition, in vitro, serum derived from CKD patients and uremia toxins induced abnormal expression of ANRIL. By making use of the gain- and loss-of-function approaches, we observed that ANRIL mediated endothelial dysfunction through BDNF downregulation. 35906216 CDKN2A-DT LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues and cells Interaction(SOSTDC1 axis) qRT-PCR//Luciferase Report Assay//Western Blot//FISH Herein, we unearthed that CDKN2A-AS1, BMP2/4/7, SMAD1/5/9 and phosphorylation of SMAD1/5/9 (p-SMAD1/5/9) were upregulated in EOC tissues and cells, whereas SOSTDC1 was downregulated in EOC tissues and cells. We firstly demonstrated that CDKN2A-AS1 bound directly with the SOSTDC1. CDKN2A-AS1 downregulated the expression of SOSTDC1, but upregulated the expression of BMP2/4/7, SMAD1/5/9, and p-SMAD1/5/9. Yes CDKN2A-AS1 downregulated the expression of SOSTDC1, but upregulated the expression of BMP2/4/7, SMAD1/5/9, and p-SMAD1/5/9. CDKN2A-AS1 promoted the proliferation, migration, invasion of EOC cells and tumor growth in vivo, whereas SOSTDC1 inhibited the proliferation, migration, invasion of EOC cells. Knockdown SOSTDC1 rescued the inhibitory effect of si-lncRNA CDKN2A-AS1 on the EOC cells proliferation, migration and invasion. 34110955 CDKN2B-AS1 LncRNA Homo sapiens Atherosclerosis blood plasma Interaction(let-7b/TGF-βR1 signalling pathway) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//ELISA ANRIL levels were increased in patients with acute coronary syndrome. The expression of ANRIL is associated with the inflammatory cytokines monocyte chemoattractant protein-1 and interleukin-10, which are secreted in response to endothelial dysfunction. Knockdown of ANRIL significantly promoted cell proliferation and tubule formation and inhibited inflammatory activation and apoptosis of human umbilical vein endothelial cells (HUVEC). ANRIL-mediated inhibition of let-7b regulates HUVEC dysfunction by targeting the TGF-βR1/Smad signalling pathway. Yes Knockdown of ANRIL significantly promoted cell proliferation and tubule formation and inhibited inflammatory activation and apoptosis of human umbilical vein endothelial cells (HUVEC). 32783191 CDKN2B-AS1 LncRNA Homo sapiens Glioma glioma cells Interaction(miR-34a/Sirt1/PI3K/AKT and mTOR pathways) Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Invasion Assay ANRIL was upregulated in glioma cells and its suppression inhibited cell proliferation, migration and invasion but promoted cell apoptosis. ANRIL acted as a sponge of miR-34a, and Sirt1 is a target of miR-34a. Then, Sirt1 was proved to function through activation of the PI3K/AKT and mTOR signaling pathways. Yes ANRIL was upregulated in glioma cells and its suppression inhibited cell proliferation, migration and invasion but promoted cell apoptosis. 29057547 CDKN2B-AS1 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-199a-5p/DDR1 axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay CDKN2B-AS1 is significantly upregulated in glioma tissues and cell lines.Further, a miR-199a-5p inhibitor attenuates the inhibitory effects of sh-CDKN2B-AS1 on these cell phenotypes. CDKN2B-AS1 positively regulates DDR1 expression by directly sponging miR-199a-5p. Yes CDKN2B-AS1 knockdown significantly inhibits cell proliferation, invasion, and migration, while promoting apoptosis of glioma cell lines U251 and U87. Moreover, CDKN2B-AS1 knockdown efficiently inhibits U87 tumor xenograft growth in mice. 34559933 CDKN2B-AS1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues interaction[GAS6] CCK8//qRT-PCR//RIP//Transwell Assay CDKN2BAS was upregulated in ovarian cancer tissues, especially those with advanced FIGO stage and high pathological grade. LncRNA CDKN2BAS is upregulated in ovarian cancer. By positively interacting with GAS6, CDKN2BAS triggers the progression of ovarian cancer. CDKN2BAS was upregulated in ovarian cancer tissues, especially those with advanced FIGO stage and high pathological grade. Yes The overexpression of CDKN2BAS enhanced proliferative and migratory potentials in HEY and SKOV-3 cells. 32572907 CDKN2B-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[miR-153-5p/ARHGAP18 signaling axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay CDKN2BAS was remarkably up-regulated in metastatic HCC tissues compared with the adjacent non-tumor tissues. Our study revealed that lncRNA CDKN2BAS promotes HCC metastasis by regulating the miR-153-5p/ARHGAP18 signaling. Yes CDKN2BAS promotes HCC cell growth and migration in vitro and in vivo. 30510148 CDKN2B-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular Regulation[NF-κB and Wnt/β-catenin pathways,miR-191] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay These data demonstrated that ANRIL knockdown suppressed proliferation, migration, invasion, and promoted apoptosis in HepG2 cells by down-regulating miR-191 and inactivating NF-κB and Wnt/β-catenin signaling pathways. Yes Knockdown of ANRIL inhibited proliferation, induced apoptosis, meanwhile suppressed migration and invasion of HepG2 cells. 30249208 CDKN2B-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[let-7c-5p/NAP1L1 axis] qRT-PCR Here, we identified a novel oncogenic lncRNA CDKN2B-AS1, which was highly expressed in HCC and positively associated with large tumor size, microvascular invasion, high tumor grade, advanced tumor stage and reduced survival of HCC patients.CDKN2B-AS1, an oncogenic lncRNA of HCC, promoted NAP1L1-mediated PI3K/AKT/mTOR signaling by acting as a molecular sponge of let-7c-5p. Here, we identified a novel oncogenic lncRNA CDKN2B-AS1, which was highly expressed in HCC and positively associated with large tumor size, microvascular invasion, high tumor grade, advanced tumor stage and reduced survival of HCC patients. Yes CDKN2B-AS1 knockdown inhibited cell proliferation, migration and invasion, and induced G1 arrest and apoptosis of HCC cells in vitro, and CDKN2B-AS1 silencing suppressed tumor growth and metastasis of HCC in vivo. 30165194 CDKN2B-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Regulation[MiR-199a-5p/ARL2 axis] qRT-PCR First, we found that lncRAN ANRIL expression was significantly increased in HCC tissues or cells compared with the normal adjacent tissues and normal tissues or cells. Mechanistically, lncRNA ANRIL acted as a competing endogenous RNA to increase ARL2 (ADP-ribosylationfactor-like 2) expression via sponging miR-199a-5p. Notably, the miR-199a-5p/ARL2 axis is necessary for ANRIL-mediated promoting effects on HCC cell mitochondrial function. This work reveals a novel ANRIL-miR-199a-5p-ARL2 axis in HCC cell progression, which might provide potential targets for HCC treatment. Yes Functional experiment showed that overexpression of lncRNA ANRIL promoted mitochondrial function in HCC cells, evident by the increased mitochondrial DNA copy numbers, ATP (Adenosine triphosphate) level, mitochondrial membrane potential, and the expression levels of mitochondrial markers, while ANRIL knockdown exerted the opposite effects. 31670868 CDKN2B-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Interaction[targeting of miR-384 and STAT3] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay ANRIL expression was upregulated in HCC cells, including SMCC7721, HepG2, MHCC-97H, SNU449 and HUH-7 cells, in comparison to the normal human liver cells LO2. ANRIL is involved in HCC progression by direct targeting of miR-384 and STAT3. Also, ANRIL could act as a potential candidate for HCC diagnosis, prognosis, and therapy. Yes Knockdown of ANRIL suppressed HCC cell proliferation and induced cell cycle arrest and apoptosis. HCC cell migration and invasion capacity were inhibited by inhibition of ANRIL. 31679275 CDKN2B-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Interaction[sponging miR-144] qRT-PCR ANRIL was highly expressed in MHCC97 and Li-7 cells when compared to THLE-3 cells. One of the possible mechanisms responsible for the tumour-promoting actions is that ANRIL sponging miR-144 to derepress PBX3. Yes ANRIL overexpression promoted cell viability, migration, invasion and suppressed apoptosis of MHCC97 and Li-7 cells. 31609763 CDKN2B-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells interaction[Sponging miR-424-5p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay CDKN2B-AS1 expression was increased in HCC tissues and cells.The present study revealed that high-expressed CDKN2B-AS1 may associate with the progression of HCC by affecting the cell viability, migration, invasion, and EMT of HCC cells by negatively regulating miR-424-5p. Yes Silencing of CDKN2B-AS1 suppressed cell viability, migration, invasion, and EMT, while overexpression of CDKN2B-AS1 produced the opposite results. 32801906 CDKN2B-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HepG2 cells Regulation(Wnt/β-catenin pathway) qRT-PCR Knocking down of ANRIL led to alleviated cell growth and increased cell apoptosis of HepG2 cells through markedly increased expression levels of Bax and Bad. In contrast, dramatically diminished the expressions of anti-apoptotic factors including Bid and Bcl-2 in comparison to the scrambled control group (si-NC). Furthermore, ANRIL silencing resulted in an inactivated Wnt/β-catenin pathway by suppressing key genes associated with this pathway. Yes Knocking down of ANRIL led to alleviated cell growth and increased cell apoptosis of HepG2 cells through markedly increased expression levels of Bax and Bad. 34111289 CDKN2B-AS1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues regulation[miR-143-3p/SMAD3 axis ] CCK8//qRT-PCR//Transwell Assay//Western Blot CDKN2B-AS1 was upregulated in OC and correlated with clinicopathologic features. In conclusion, CDKN2B-AS1 promoted tumor growth, invasion, and migration of OC by regulation of miR-143-3p/SMAD3 axis, hinting that CDKN2B-AS1 might be a potential biomarker for OC diagnosis and treatment. Yes The knockdown of CDKN2B-AS1 hampered the development of OC, as reflected by the suppression of cell proliferation, migration, and invasion, and the enhancement of cell apoptosis, whereas the effects could be rescued by the overexpression of SMAD3. 32305052 CDKN2B-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cell lines Regulation[miR-181a-5p/TGFβI axis] Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//IHC//Invasion Assay//Transwell Assay In the present study, RT-PCR showed that the mRNA level of CDKN2B-AS1 was significantly upregulated while the miR-181a-5p was downregulated in cervical cancer cell lines. In summary, our study demonstrated that the CDKN2B-AS1/miR-181a-5p/TGFβI axis might play a vital role in cervical cancer development. Yes In addition, the interference of CDKN2B-AS1 by shRNA resulted in the suppression of cell proliferation, invasion, migration and promotion of apoptosis and senescence, and either CDKN2B-AS1 overexpression or miR-181a-5p showed reversed results. 30884187 CDKN2B-AS1 LncRNA Homo sapiens Ovarian Neoplasms OVCAR-3 cell lines Interaction(Wnt/β-catenin) CCK8//qRT-PCR//Western Blot ANRIL down-regulating in OVCAR-3 cell lines resulted in significant inhibition of cellular proliferation, apoptosis induction, as well as suppression of cellular invasion. More importantly, we observed that ANRIL inhibition suppressed the vital components expression of the Wnt/β-catenin cascade. Yes ANRIL down-regulating in OVCAR-3 cell lines resulted in significant inhibition of cellular proliferation, apoptosis induction, as well as suppression of cellular invasion. Besides, knockdown of ANRIL led to pro-apoptotic genes up-regulation, Bad and Bax and anti-apoptotic genes down-regulation, Bid and Bcl-2. 33772549 CDKN2B-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and blood Interaction[TGF-β/Smad pathway] Flow Cytometry//MTT//Western Blot The lncRNA ANRIL was highly expressed in the tissues and serum of patients.The lncRNA ANRIL regulates the TGF-β/Smad signaling pathway to promote the proliferation and suppress the apoptosis of OSCC cells. Yes The proliferation ability of the cells transfected with si-ANRIL was significantly reduced, while that of the cells transfected with ANRIL-OE was overtly increased. 31364119 CDKN2B-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues Regulation[miR-125a-3p/FGFR1/MAPK signaling] IHC//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay In this study, we found that ANRIL expression was upregulated in HNSCC and correlated with tumor progression. Thus, it could be concluded that ANRIL promoted the progression of HNSCC via miR-125a-3p/FGFR1/MAPK signaling, which might provide a new target for the diagnosis and treatment of HNSCC. Yes Further functional analysis showed that knockdown of ANRIL significantly inhibited proliferation in vivo and in vitro. 30555745 CDKN2B-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay CDKN2B-AS1 was found to be markedly up-regulated in OS tissues and cell lines. Clinical data further demonstrated highly expressed CDKN2B-AS1 tended to be strongly positively correlated with tumor size, distant metastasis and TNM stage. Yes Loss-of-function of CDKN2B-AS1 leaded to inhibited cell proliferation and induced cell cycle G0/G1 phase arrest. In addition, CDKN2B-AS1 knockdown significantly suppressed OS cells migration and invasion. 31724892 CDKN2B-AS1 LncRNA Homo sapiens Osteosarcoma OS samples and cells regulation[microRNA-122/CCNG1 axis] CCK8//qRT-PCR//EdU Staining//Transwell Assay In the current investigation, RT-qPCR showed that CDKN2B-AS1 was enhanced in OS samples and cells.We displayed that CDKN2B-AS1 repressed miR-122-5p to restore CCNG1 expression. Yes Those in vitro investigations specified that silencing of CDKN2B-AS1 with shRNAs obviously impeded the proliferation and invasion of MG63 cells. 33283575 CDKN2B-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells interaction[MAP3K3,miR-4458] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay In this study, we firstly assessed the expression of CDKN2B-AS1 in OS tissues and cells, showing that CDKN2B-AS1 expression were remarkably upregulated in OS tissues and cells.Our results suggested that CDKN2B-AS1 facilitated OS progression by sponging miR-4458 to enhance MAP3K3 expression, which provides a novel insight into improving diagnostic and therapeutic strategies for patients with OS. Yes Moreover, CDKN2B-AS1 knockdown suppressed cell proliferation, migration, and EMT progress in OS. 31950433 CDKN2B-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow Regulation[regulating miR-34a] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining//Transwell Assay ANRIL was up-regulated both in the BM samples from AML patients and cell lines (HL-60 and THP-1), of which expression was negatively correlated with miR-34a expression.ANRIL promotes AML development through HDAC1-mediated epigenetic suppression of ASPP2 via negatively regulating miR-34a, which might serve as a therapeutic target for AML treatment. Yes ANRIL knockdown inhibited cell proliferation, migration and invasion but promoted apoptosis of AML cells, while overexpression of miR-34a exerted opposite effects. miR-34a was verified as a downstream gene targeted by ANRIL. 31830533 CDKN2B-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Expression[highly expressed] qRT-PCR Then further verification was obtained by means of RT-qPCR that ANRIL was highly expressed in CC tissues. Yes In addition, high expression of ANRIL was related to increased E-cadherin expression, high migration of CC as well as decreased cell apoptosis rate. 30198868 DANCR LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues and cells Interaction( miR-496/mTOR) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//IHC In this study, we demonstrated that differentiation antagonizing non-protein coding RNA (DANCR) was up-regulated in lung adenocarcinoma (ADC) and that the knockdown of DANCR inhibited tumour cell proliferation, migration and invasion and restored cell apoptosis rescued; cotransfection with a miR-496 inhibitor reversed these effects. Luciferase reporter assays showed that miR-496 directly modulated DANCR; additionally, we used RNA-binding protein immunoprecipitation (RIP) and RNA pull-down assays to further confirm that the suppression of DANCR by miR-496 was RISC-dependent. Our study also indicated that mTOR was a target of miR-496 and that DANCR could modulate the expression levels of mTOR by working as a competing endogenous RNA (ceRNA). Yes In this study, we demonstrated that differentiation antagonizing non-protein coding RNA (DANCR) was up-regulated in lung adenocarcinoma (ADC) and that the knockdown of DANCR inhibited tumour cell proliferation, migration and invasion and restored cell apoptosis rescued; cotransfection with a miR-496 inhibitor reversed these effects. Furthermore, the knockdown of DANCR reduced tumour volumes in vivo compared with those of the control group. 29266795 DANCR LncRNA Homo sapiens Adenocarcinoma of Lung LAD tissue and cell lines Regulation[DANCR/HMGA2 axis ] qRT-PCR//IHC//Western Blot//Transwell Assay In the present study, it was revealed that the lncRNA DANCR was upregulated in LAD tissue and cell lines, compared with para‑tumor tissue and a normal lung cell line. Furthermore, HMGA2 was overexpressed in LAD tissue and in SPCA1 and A549 cells, compared with para‑tumor tissue and a normal lung cell line. Inhibition of HMGA2 suppressed the invasive ability of SPCA1 and A549 cells, and DANCR promoted the invasive ability via regulation of HMGA2 in SPCA1 and A549 cells. The findings of the present study revealed that DANCR promoted the invasion of LAD cells by positively regulating HMGA2. Thus, a DANCR/HMGA2 axis may be a novel potential target in the molecular treatment of LAD. Yes Functionally, the study revealed that knockdown of DANCR inhibited invasion and HMGA2 expression in the LAD cell lines, SPCA1 and A549. 30535487 DANCR LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines Interaction[miR-33b/MMP16] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the current study, we demonstrate that DANCR was increased in PC tissues and cell lines. In addition, we identified direct binding to the predicted miR-33b binding site on DANCR. We also showed that there is reciprocal repression between DANCR and miR-33b. Furthermore, a miR-33b inhibitor partially abrogated knockdown of DANCR and caused inhibitory effects. We also demonstrated that DANCR functions as a miR-33b sponge to positively regulate MMP16 expression in PC cells. Collectively, the data reveal that DANCR exerts its function by regulating miR-33b/MMP16 expression, implying an important role for a lncRNA-miRNA-mRNA functional network and suggesting a novel potential therapeutic target for PC. Yes Knockdown of DANCR significantly suppressed cell proliferation, migration, and invasion and influenced the levels of epithelial-to-mesenchymal transition-associated proteins, as demonstrated by the observation of enhanced E-cadherin levels and reduced N-cadherin levels in PC cells. 31515968 DSCAM-AS1 LncRNA Homo sapiens stomach carcinoma GC tissues and cell lines Interaction(miR-204/TPT1 axis) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay//Transwell Assay In this study, we found that DSCAM-AS1 was significantly overexpressed in GC tissues and cell lines. We identified miR-204 as a target of DSCAM-AS1 and found that it targeted TPT1 in GC cells, which further led to decreased expression of miR-204 in GC tissues and cell lines. A rescue assay revealed that knocked-down DSCAM-AS1 hindered GC progression, which was reversed upon miR-204 downregulation or TPT1 overexpression. Yes Functional experiments indicated that GC cells with DSCAM-AS1 silencing exhibited a dynamic reduction in proliferation and migration. 34372727 DSCAM-AS1 LncRNA Homo sapiens endometrial adenocarcinoma endometrial cancer Expression(highly expressed) Western Blot//Transfection//qRT-PCR//Cell Apoptosis Assay//Microarray Initial analysis of open-source data revealed DSCAM-AS1 overexpression in endometrial cancer (EC) (p < 0.01) and a significant association with shorter overall survival of EC patients (HR = 1.78, p < 0.01). Yes DSCAM-AS1 knockdown triggered an anti-tumoral transcriptome response as revealed by Affymetrix microarray analysis, emerging from down-regulation of tumor-promoting genes and induction of tumor-suppressive networks. Finally, several genes regulated upon DSCAM-AS1 silencing in vitro were found to be inversely correlated with this lncRNA in EC tissues. 35885035 DRHC LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[miR-8075 ] CCK8//qRT-PCR The present study revealed that lncRNA DRHC was Expression[down-expression]regulated and lncRNA Hox transcript antisense RNA (HOTAIR) was Expression[Expression[up-expression]-expression]regulated in tumor tissues compared with adjacent healthy tissues in patients with triple negative breast cancer (TNBC).The results obtained in the current study suggested that lncRNA DRHC may inhibit the proliferation of TNBC cells by Expression[down-expression]regulating the expression of lncRNA HOTAIR. Yes In vitro overexpression of lncRNA DRHC in TNBC cell lines resulted in decreased expression of lncRNA HOTAIR; however, lncRNA HOTAIR overexpression did not affect the expression level of lncRNA DRHC. Overexpression of lncRNA DRHC inhibited, while overexpression of lncRNA HOTAIR promoted the proliferation of the TNBC cell lines. In addition, lncRNA HOTAIR overexpression attenuated the inhibitory effects of lncRNA DRHC overexpression on cancer cell proliferation. 31516593 DRHC LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Regulation[MEK/ERK signaling] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH Here, we reported a novel lncRNA, CTC-505O3 (lncRNA DRHC), that was downregulated in HCC and its low expression was associated with dismal survival. oreover, we found that lncRNA DRHC interacted with MYBBP1A and modulated MEK/ERK signaling via c-Myb. Here, we reported a novel lncRNA, CTC-505O3 (lncRNA DRHC), that was downregulated in HCC and its low expression was associated with dismal survival. Yes Gain-of-function studies indicated that it inhibited proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in HCC cell lines in vitro. lncRNA DRHC also inhibited tumorigenicity in vivo. 30362626 DRAIC LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines interaction[UCHL5 and NFRKB ] Western Blot//Co-IP//CCK8//qRT-PCR//Transwell Assay DRAIC is down-regulated in GC tissues and cell lines while its potential interacting molecules UCHL5 and NFRKB are up-regulated, and DRAIC is positively correlated with NFRKB protein instead of mRNA. DRAIC suppresses GC proliferation and metastasis via interfering with the combination of UCHL5 and NFRKB and mediating ubiquitination degradation. Lower DRAIC and higher UCHL5 and NFRKB indicated advanced progression of GC patients. Yes DRAIC combined with UCHL5 and attenuated binding of UCHL5 and NFRKB, meanwhile promoting the degradation of NFRKB via ubiquitination, and then inhibited the proliferation and metastasis of GC cells, which can be rescued by oeNFRKB. 32351584 DRAIC LncRNA Homo sapiens Esophageal Neoplasms EC cells regulation[miR-149-5p/NFIB] qRT-PCR//RNA Pull-Down DRAIC and NFIB showed high expression in EC cells, while miR-149-5p showed low expression. Moreover, DRAIC has an effect on the autophagy of EC cells through miR-149-5p/NFIB. Yes Down-regulating DRAIC, NFIB and over-expressing miR-149-5p can inhibit EC cells' proliferation and invasion, and improve apoptosis and autophagy. 32659236 DRAIC LncRNA Homo sapiens Glioma glioma tissues,cell lines interaction[ targeting miR-18a-3p] ChIP//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Compared with adjacent non-cancerous normal tissues, SET7/9 and DRAIC were both downregulated and miR-18a-3p was upregulated in glioma cells. In this research, we discovered that the expression of SET7/9 was low in glioma cells and SET7/9-mediated H3K4me3 enrichment on the DRAIC promoter regulated the growth and metastasis of glioma cells by targeting miR-18a-3p. Yes In U251 cells, SET7/9 and DRAIC overexpression inhibited cell proliferation, migration and invasion. The inhibition of DRAIC promoted the growth and metastasis of U251 cells, while the co-transfection of si- DRAIC and miR-18a-3p further promoted the growth and metastasis of U251 cells. 33336743 DRAIC LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Regulation[DRAIC-miR-122-SATB1 axis ] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP In this study, we found that DRAIC was significantly increased in NPC tissues. In conclusion, these findings revealed the important roles of DRAIC-miR-122-SATB1 axis in NPC and suggested that DRAIC may be a potential therapeutic target for NPC. Yes Functional assays revealed that ectopic expression of DRAIC enhances NPC cell growth, migration and invasion. DRAIC knockdown represses NPC cell growth, migration and invasion. 31497998 DRAIC LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(miR-3940-3p axis) Transfection//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay lnc DRAIC was upregulated in LUAD tissues and cells, but miR-3940-3p was downregulated. Lnc-DRAIC and miR-3940-3p have the potential as independent prognostic factors for LUAD. Furthermore, the inhibition of lnc DRAIC can inhibit cell proliferation, migration, and invasion of LUAD partly as a ceRNA of miR-3940-3p. Both of them showed significant associations with and TNM stage, lymph node metastasis, and a poor prognosis. Yes Lnc-DRAIC and miR-3940-3p have the potential as independent prognostic factors for LUAD. Furthermore, the inhibition of lnc DRAIC can inhibit cell proliferation, migration, and invasion of LUAD partly as a ceRNA of miR-3940-3p. 34764698 DRAIC LncRNA Homo sapiens Hirschsprung Disease colon tissue Interaction(miR-34a-5p/ITGA6 signal axis) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The lncRNA DRAIC was significantly increased in colon tissue from HSCR patients. The RNA pull-down and dual-luciferase reporter assays have proven the competitive relationship between DRAIC and ITGA6 through their association with miR-34a-5p. Yes The overexpression of DRAIC inhibited SH-SY5Y cell and human 293T cell proliferation and migration. Knockdown of DRAIC, however, promoted cell proliferation and migration. 34471485 DQ786243 LncRNA Homo sapiens Carcinoma, Hepatocellular liver cancer and HCC cell Interaction(miR‑15b‑5p/Wnt3A axis) qRT-PCR lncDQ and Wnt3A expression were significantly increased in HCC tissues, whereas miR‑15b‑5p was downregulated in HCC tissues. Low expression of miR‑15b‑5p was also associated with poor prognoses for patients with HCC. lncDQ was able to bind with miR‑15b‑5p and served as a competing endogenous RNA. As the target gene of miR‑15b‑5p, Wnt3A was correlated with poor prognoses for patients with HCC. lncDQ inhibited miR‑15b‑5p so as to promote HCC cell invasion and proliferation through activation of the Wnt3A/β‑catenin/EMT pathway. Low expression of miR‑15b‑5p was also associated with poor prognoses for patients with HCC. Yes Silencing of lncDQ expression significantly attenuated proliferation and invasion of liver cancer and HCC cells, however the inhibition of miR‑15b‑5p was able to reverse this effect. However, silencing of lncDQ and miR‑15b‑5p expression simultaneously resulted in the partial rescue of the inhibitory effect in the liver cancer and HCC cells. 33760109 DPP10-AS1 LncRNA Homo sapiens Lung Neoplasms cancer tissues Interaction(DPP10) In Vivo Experiment//qRT-PCR//MTT//Cell Cycle Assay//Colony Formation Assay The novel antisense lncRNA DPP10-AS1 was found to be highly expressed in cancer tissues (P < 0.0001), and its upregulation predicted poor prognosis in patients with lung cancer (P = 0.0025).Importantly, DPP10-AS1 positively regulated DPP10 gene expression, and both were coordinately upregulated in lung cancer tissues. Mechanically, DPP10-AS1 was found to associate with DPP10 mRNA but did not enhance DPP10 mRNA stability. The novel antisense lncRNA DPP10-AS1 was found to be highly expressed in cancer tissues (P < 0.0001), and its upregulation predicted poor prognosis in patients with lung cancer (P = 0.0025). Yes Notably, DPP10-AS1 promoted lung cancer cell growth, colony formation, and cell cycle progression, and repressed apoptosis in lung cancer cells by upregulating DPP10 expression. Additionally, DPP10-AS1 facilitated lung tumor growth via upregulation of DPP10 protein in a xenograft mouse model. 34106559 DPP10-AS1 LncRNA Homo sapiens Colonic Neoplasms CCSCs Interaction(miR-127-3p and ADCY1) CCK8//qRT-PCR//Western Blot//Transwell Assay Poorly expressed DPP10-AS1 and ADCY1, while highly expressed miR-127-3p were found in CCSCs. Taken together, this study demonstrates that DPP10-AS1 inhibits CCSC proliferation by regulating miR-127-3p and ADCY1, providing fresh insight into a promising novel treatment strategy for colon cancer. Low expression of DPP10-AS1 was correlated with TNM stage, lymphatic node metastasis, and tumor differentiation. Yes Upregulation of DPP10-AS1 increased ADCY1 protein expression, decreased the protein expression of CCSC-related factors, inhibited sphere formation, colony formation, proliferation, invasion and migration, and accelerated apoptosis of HT-29 and SW480 cells by suppressing the expression of miR-127-3p. Further, the above in vitro findings were also confirmed by in vivo assays. 33744851 DOCK9-DT LncRNA Homo sapiens Thyroid Cancer, Papillary exosomes regulation[ Wnt/β-catenin pathway] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Based on the result of differentially expressed lncRNAs in PTC via bioinformatics databases, we discovered that DOCK9-AS2 was upregulated in PTC, and presented elevation in plasma exosomes of PTC patients. In conclusion, PTC-CSCs-derived exosomal lncRNA DOCK9-AS2 activated Wnt/β-catenin pathway to aggravate PTC progression, indicating that DOCK9-AS2 was a potential target for therapies in PTC. Yes Functionally, DOCK9-AS2 knockdown reduced proliferation, migration, invasion, epithelial-to-mesenchymal (EMT) and stemness in PTC cells. 32917852 DOCK1 CircRNA Homo sapiens bladder carcinoma BC tissues,cell lines Interaction[circDOCK1/hsa-miR-132-3p/Sox5 pathway] Western Blot//qPCR//Luciferase Report Assay//Microarray//EdU Staining//Transwell Assay CircDOCK1 was Expression[Expression[up-expression]-expression]regulated in BC tissues and cell lines. CircDOCK1 played its role via regulation of circDOCK1/hsa-miR-132-3p/Sox5 pathway in BC cells. Yes Repression of circDOCK1 reduced cell viability, inhibited cell proliferation and curbed the cell migration potential of BC cell. SExpression[Expression[up-expression]-expression]pression circDOCK1 inhibited the tumour growth in vivo. 30983072 DNM3OS LncRNA Homo sapiens Stomach Neoplasms GC tissues,cell lines Expression[Expression[highly expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH We observed that DNM3OS was Expression[Expression[up-expression]-expression]regulated in GC tissues and cell lines, and high DNM3OS expression was correlated with malignant features and served as an indicator of a poor prognosis for GC patients. We observed that DNM3OS was Expression[Expression[up-expression]-expression]regulated in GC tissues and cell lines, and high DNM3OS expression was correlated with malignant features and served as an indicator of a poor prognosis for GC patients Yes DNM3OS knockExpression[down-expression] inhibited the proliferation of GC cells, and reduced DNM3OS sExpression[Expression[up-expression]-expression]pressed tumor growth in vivo. 30770102 DNM3OS LncRNA Homo sapiens Osteoarthritis OA tissues Interaction[sponging miR-126] qRT-PCR//Luciferase Report Assay//RIP//Western Blot The expression of DNM3OS was down-regulated in OA patients. Our results showed that DNM3OS could affect the CHON-001 cell proliferation and apoptosis by regulating IGF1 by sponging miR-126. Yes Functional assays demonstrated that ectopic expression of DNM3OS promoted the proliferation and inhibited apoptosis of CHON-001 cells, and that knocking down DNM3OS suppressed cell proliferation and induced apoptosis. 31526393 DNM3OS LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(KDM6B/TIAM1 axis) qRT-PCR DNM3OS was significantly upregulated in HCC compared to adjacent liver tissues. Biochemically, DNM3OS was mainly localized in the nucleus and physically interacted with KDM6B. The association of DNM3OS with KDM6B induced the expression of TIAM1 through reduction of H3K27me3 at the TIAM1 promoter. High DNM3OS expression was associated with TNM stage, vascular invasion, and poor prognosis of HCC patients. Yes Silencing of DNM3OS inhibited HCC cell proliferation and invasion in vitro and tumorigenesis and metastasis in vivo. Overexpression of DNM3OS enhanced HCC cell proliferation, invasion, and metastasis. 33472090 DNM3OS LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines Interaction( miR-193a-3p/MAP3K3 Axis) qRT-PCR//Bioinformatics Analysis//RIP//Western Blot DNM3OS expression was remarkably increased in OC tissues and cell lines, which was associated with the unfavorable prognosis of the patients. DNM3OS directly interacted with miR-193a-3p, and miR-193a-3p targeted MAP3K3 by directly binding to 3'UTR. DNM3OS could up-regulate the expression of MAP3K3 via repressing miR-193a-3p expression. DNM3OS expression was remarkably increased in OC tissues and cell lines, which was associated with the unfavorable prognosis of the patients. Yes DNM3OS overexpression enhanced OC cell proliferation, migration, and invasion; suppressed E-cadherin protein expression; and facilitated N-cadherin protein expression, while the transfection of miR-193a-3p mimics had the opposite effects. 34027641 DNM3OS LncRNA Homo sapiens Mouth Neoplasms oral cancer tissues and cells regulation[DNM3OS/miR-204-5p/HIP1 axis ] RNA-seq//Microarray DNM3OS was upregulated in oral cancer tissues and cells.Within oral carcinoma tissue samples, expression of DNM3OS and HIP1 was increased whereas the miR-204-5p expression was downregulated; miR-204-5p had a negative correlation with DNM3OS and HIP1, respectively, while DNM3OS and HIP1 were positively correlated with each other. Yes DNM3OS knockdown in CAL27 and SCC-9 cells inhibited cell viability and migration. 32463958 DSCAM-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical carcinoma specimens Interaction(miR-338-3p) Cell Proliferation Assay//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay DSCAM-AS1 was upregulated in cervical carcinoma specimens compared to control no-tumor specimens.Moreover, our data revealed that miR-338-3p expression was downregulated in cervical carcinoma cells and specimens. There was a negative correlation between miR-338-3p expression and DSCAM-AS1 expression in cervical carcinoma specimens. Elevated expression of miR-338-3p decreased cervical carcinoma cell growth and cycle and invasion. Yes Overexpression of DSCAM-AS1 induced cervical carcinoma cell growth and cycle. 35378649 DSCAM-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and cells Interaction(miR-136-5p) In Vivo Experiment//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay It was revealed that DSCAM-AS1 was expressed at a high level in EC tissues and cells after analyzing patient data and data obtained from The Cancer Genome Atlas. Furthermore, it was revealed that DSCAM-AS1 acted as a microRNA (miR)-136-5p sponge to exert its oncogenic roles in EC. Notably, it was also revealed that high DSCAM-AS1 expression was associated with a less favorable overall survival in patients with EC. Yes Knockdown of DSCAM-AS1 was able to suppress EC cell proliferation by upregulating cell apoptosis in vitro. 34691252 DNAJC3-DT LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[receptor/phosphatidylinositol 3-kinase/protein kinase B/nuclear factor κB signaling pathway] Western Blot//ISH//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay By constructing a differential lncRNA expression profile, we screened gene chips and found that DNAJC3-AS1 was highly expressed in CRC tissues and was associated with poor prognosis in patients with CRC. Mechanically, we found that DNAJC3-AS1 regulates fatty acid synthase to promote the progression of CRC via the epidermal growth factor receptor/phosphatidylinositol 3-kinase/protein kinase B/nuclear factor κB signaling pathway. By constructing a differential lncRNA expression profile, we screened gene chips and found that DNAJC3-AS1 was highly expressed in CRC tissues and was associated with poor prognosis in patients with CRC. Yes Further, we proved through assays such as wound healing, colony formation, and Cell Counting Kit-8 (CCK8) that interfering with DNAJC3-AS1 could reduce the proliferation, migration, and invasion of CRC cells. 33604287 DSCAM-AS1 LncRNA Homo sapiens Melanoma melanoma tissues and cell lines Interaction[sponging miR-136] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this research, we showed that the expression of DSCAM-AS1 was significantly upregulated in melanoma samples and cell lines. Furthermore, mechanistic investigations indicated that DSCAM-AS1 could interact with miR-136 and negatively influence the expression of miR-136. Clinical investigation indicated that higher expression of DSCAM-AS1 was associated with ulceration and advanced stage and led to significantly poorer survival time. High DSCAM-AS1 expression in melanoma was confirmed to be an independent predictor of poor survival of patients using univariate and multivariate analysis. Yes  Functional investigations revealed that knockdown of DSCAM-AS1 inhibited the ability of cell proliferation, colony formation, migration, invasion, whereas promoted cell apoptosis. 31002140 DUXAP10 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[HuR/Sox12 axis] qRT-PCR//RIP//IF Here, we show that DUXAP10 is overexpressed in glioma tissues and cells. Further rescuing experiments show that the HuR/Sox12 axis is responsible for DUXAP10-mediated effects on glioma cell stemness. Yes Loss of function experiments reveal that DUXAP10 knockdown has little effects on glioma cell viability, but significantly reduces the stemness of glioma cells, which is characterized as the decrease of stemness marker expression, tumor sphere-forming ability, and ALDH activity. 33340249 DUXAP10 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells Interaction( EZH2 and LSD1) In Vivo Experiment//Transfection//Invasion Assay//Migration Assay//Flow Cytometry//qRT-PCR//RIP//Microarray//Colony Formation Assay//Bioinformatics Analysis In this study, we found that DUXAP10 was overexpressed in PC tissues compared with normal tissues. Mechanistic studies revealed that DUXAP10 has a crucial role in G2/M arrest. We further showed that DUXAP10 regulated PC cell proliferation through interact with RNA-binding protein EZH2 and LSD1. DUXAP10 expression was significantly higher in patients with an advanced TNM stage and positive lymph node metastasis. Yes Bioinformatic analysis showed that cell cycle progression was increased in patients with high DUXAP10 expression. In vitro and in vivo assays of DUXAP10 alterations revealed a complex integrated phenotype affecting cell growth, apoptosis, migration, and invasion. 29286182 DUXAP10 LncRNA Homo sapiens Prostatic Neoplasms cell lines Expression[highly expressed] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay Results showed that the expression of DUXAP10 was higher in PC3 and DU145 cell lines than that in the 22RV1 cell line. Yes Additionally, the knockdown of DUXAP10 could remarkably inhibit the proliferation, migration, and induce apoptosis of prostate cancer cells, and significantly increase the number of G0/G1 cells in PC3 and DU145 cell lines. 31114994 DUXAP10 LncRNA Homo sapiens Melanoma MM tissues and cells Interaction[Suppressing CADM1 ] RIP//Wound Healing Assay//qRT-PCR//Transwell Assay Here, we found that LNMAT1 was upregulated in MM tissues and cells, and its expression levels were further enhanced in MM patients with lymph node metastasis and metastatic MM cells.Lastly, rescue assays demonstrated that LNMAT1 promoted cell migration and invasion of MM by suppressing CADM1 expression. Here, we found that LNMAT1 was upregulated in MM tissues and cells, and its expression levels were further enhanced in MM patients with lymph node metastasis and metastatic MM cells. Yes Using loss-of-function assays, we found that LNMAT1 promoted cell migration and invasion and lung metastasis in MM in vitro and in vivo. 31334110 DUSP5P1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(ARHGAP5 ) FISH We demonstrated that gastric cancer (GC) patients with high DUSP5P1 expression had shortened survival in two independent cohorts. Mechanistically, DUSP5P1 activated ARHGAP5 transcription by directly binding to the promoter of ARHGAP5 with a binding motif of TATGTG. RNA-seq revealed that ARHGAP5 activated focal adhesion and MAPK signaling pathways to promote GC metastasis. Yes DUSP5P1 promoted GC cell migration and invasion in vitro and metastasis in vivo. 36307394 DUSP16 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-432-5p/E2F6 Axis) Western Blot//Transfection//qPCR//Flow Cytometry//RIP//IF//PCR//IP//Bioinformatics Analysis//Transwell Assay CircDUSP16 expression was upregulated in CRC tissues and cell lines. CircDUSP16 caused a negative regulation in miR-432-5p expression. In addition, E2F6 expression was elevated in CRC tissues.Inhibition of miR-432-5p promoted the proliferative and metastatic activity of CRC cells and inhibited the induction of apoptosis. Inhibition of E2F6 expression partially abolished the effects caused by miR-432-5p depletion. Moreover, circDUSP16 upregulated E2F6 expression by reducing miR-432-5p expression. High circDUSP16 expression was correlated with low survival rate. Yes Furthermore, circDUSP16 silencing repressed CRC tumor growth in vivo. Furthermore, circDUSP16 knockdown repressed cell proliferation, migration, and invasion and induced apoptosis in CRC. 34456589 DUBR LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cell lines (H1975, A549) Regulation(c-Myc/DUBR/ZBTB11 axis) Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay//ChIP Analysis of mRNA expression in The Cancer Genome Atlas (TCGA) LUAD database and in-house LUAD cohort (n = 94) showed that DUBR was significantly downregulated in LUAD, and was associated with poor prognosis. In LUAD cell lines (H1975, A549), overexpression of DUBR significantly suppressed the migration and invasion of the LUAD cells. We demonstrated that c-Myc could bind to the promoter of DUBR, and transcriptionally suppressed its expression. Knockdown of c-Myc almost completely blocked the invasion and migration of LUAD cells, whereas knockdown of DUBR partially rescued c-Myc-knockdown suppressed cell migration and invasion. Furthermore, DUBR overexpression significantly increased the expression of a downstream protein of DUBR, zinc finger, and BTB domain containing 11 (ZBTB11), in H1975 and A549 cells; knockdown of ZBTB11 partially rescued the DUBR-overexpression suppressed cell migration and invasion; knockdown of c-Myc significantly upregulated the expression of ZBTB11 in LUAD cells. Finally, we revealed that DUBR/ZBTB11 axis suppressed oxidative phosphorylation in LUAD cells. In short, we demonstrate that c-Myc/DUBR/ZBTB11 axis suppresses migration and invasion of LUAD by attenuating cell oxidative phosphorylation, which provides new insights into the regulatory mechanism of DUBR. Analysis of mRNA expression in The Cancer Genome Atlas (TCGA) LUAD database and in-house LUAD cohort (n = 94) showed that DUBR was significantly downregulated in LUAD, and was associated with poor prognosis. Yes Knockdown of c-Myc almost completely blocked the invasion and migration of LUAD cells, whereas knockdown of DUBR partially rescued c-Myc-knockdown suppressed cell migration and invasion. Furthermore, DUBR overexpression significantly increased the expression of a downstream protein of DUBR, zinc finger, and BTB domain containing 11 (ZBTB11), in H1975 and A549 cells; knockdown of ZBTB11 partially rescued the DUBR-overexpression suppressed cell migration and invasion; knockdown of c-Myc significantly upregulated the expression of ZBTB11 in LUAD cells. 33758355 DSCR8 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(miR-137/Cdc42) In Vivo Experiment//RNA Pull-Down//Western Blot//Invasion Assay//Tunel//qRT-PCR//RIP//FISH//MTT//Luciferase Report Assay//Cell Cycle Assay//IHC//Bioinformatics Analysis//Transwell Assay Here, qRT-PCR detected upregulated expression of DSCR8 and Cdc42 and downregulated expression of miR-137 in GC. Dual-luciferase reporter gene, RNA immunoprecipitation, and biotin pull-down assays showed that DSCR8 could bind to miR-137 could bind to Cdc42. Statistical analysis showed that DSCR8 was closely associated with some malignant clinicopathological features (such as tumor size, metastasis, and stage) in GC patients. Yes In vitro and in vivo assays showed that DSCR8 could promote proliferation, invasion, and the cycle of GC cells and inhibit cell apoptosis. In addition, a rescue experiment showed that DSCR8 regulated progression of GC cells via miR-137. 34553033 DSCR8 LncRNA Homo sapiens Ovarian Neoplasms OC tissues regulation[DSCR8/miR-98-5p/STAT3/HIF-α axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay DSCR8 was remarkedly increased in OC tissues and associated with poorer survival of OC patients. The present results suggested a positive feedback loop of lncRNA DSCR8/miR-98-5p/STAT3/HIF-α axis in the progression of OC. DSCR8 was remarkedly increased in OC tissues and associated with poorer survival of OC patients. Yes Overexpressing DSCR8 promoted cell proliferation, invasion, and EMT but inhibited apoptosis. 32984052 DSCAM-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-577/HMGB1 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay DSCAM-AS1 and HMGB1 were upregulated, while miR-577 was downregulated in NSCLC tissues and cells. In conclusion, DSCAM-AS1 facilitated NSCLC progression by regulating the HMGB1-mediated Wnt/β-catenin pathway, providing a promising therapeutic target for NSCLC. Yes DSCAM-AS1 promoted cell proliferation, migration and invasion, and restrained cell apoptosis in NSCLC cells. 32386483 DSCAM-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC samples regulation[DSCAM-AS1/miR-122-5p Axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay FSTL3 and DSCAM-AS1 were remarkably up-regulated in NSCLC samples, and miR-122-5p was down-regulated. Taken together, our study identified that FSTL3 was a new oncogene of NSCLC, which was regulated by DSCAM-AS1 and miR-122-5p. FSTL3 was associated with worse prognosis of NSCLC patients. Yes FSTL3 knockdown markedly inhibited the viability, migration and invasion of NSCLCs in vitro and in vivo. 32280246 DSCAM-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines interaction[miR-384,AKT3] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//Transwell Assay Here, we discovered that the expression of DSCAM-AS1 exhibited a significant upregulation in CRC tissues and cell lines in comparison with the corresponding control. In summary, DSCAM-AS1 exerted an oncogenic role in CRC by functioning as a competing endogenous RNA of miR-384 to bring about regulation of AKT3 expression. Increased DSCAM-AS1 expression was associated with poor prognosis for those diagnosed with CRC. Yes Loss-of function assay illustrated that knockdown of DSCAM-AS1 resulted in significant inhibition of cell proliferation, invasion and migration in vitro, and impaired tumor growth in vivo. 32453706 DSCAM-AS1 LncRNA Homo sapiens Colonic Neoplasms CC tissues regulation[ miR-204/SOX4 Axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay DSCAM-AS1 was significantly upregulated in CC and high expression of DSCAM-AS1 was associated with poor prognosis in patients with colon cancer. The present study demonstrated that DSCAM-AS1 acted as an oncogenic lncRNA in CC progression by regulating miR-204/SOX4 axis and DSCAM-AS1 may serve as a novel therapeutic target in the treatment of colon cancer. Yes Knockdown of DSCAM-AS1 significantly suppressed CC cells proliferation and migration. 32606930 DSCAM-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-124 ) Other DSCAM-AS1 was upregulated, while miR-124 was downregulated in HCC tissues. DSCAM-AS1 and miR-124 were inversely correlated across HCC tissues but not normal tissues. miR-124 overexpression increased DSCAM-AS1 level while DSCAM-AS1 overexpression decreased miR-124 level. DSCAM-AS1 level increased, while miR-124 level decreased along with the clinical stage increasing. Yes In addition, miR-124 overexpression decreased HCC cell proliferation, while DSCAM-AS1 increased HCC cell proliferation. 35695605 DSCAM-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction(miR-138-5p/EZH2 axis.) qRT-PCR//MTT//Transwell Assay//Western Blot DSCAM-AS1 expression was remarkably increased in OSCC tissues and cell lines, and DSCAM-AS1 knockdown could significantly restrain OSCC cell proliferation, migration, and invasion.MiR-138-5p was identified as a target of DSCAM-AS1, and its inhibitor could reverse the suppressive effects of DSCAM-AS1 knockdown on OSCC progression. EZH2 was verified as a target of miR-138-5p, and EZH2 knockdown could counteract the promotional impact of miR-138-5p inhibitor on OSCC progression. Additionally, DSCAM-AS1, as a ceRNA, could regulate EZH2 expression via miR-138-5p. Yes DSCAM-AS1 expression was remarkably increased in OSCC tissues and cell lines, and DSCAM-AS1 knockdown could significantly restrain OSCC cell proliferation, migration, and invasion. 35717565 DSCAM-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells interaction[sponging miR-101] qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay In the present study, it was demonstrated that DSCAM-AS1 expression was significantly upregulated in OS tissues and cells and high expression of DSCAM-AS1 predicted poor prognosis in OS patients. The present study demonstrated that DSCAM-AS1 accelerated OS cell progression by sponging miR-101, which might provide a new sight in the treatment of OS. In the present study, it was demonstrated that DSCAM-AS1 expression was significantly upregulated in OS tissues and cells and high expression of DSCAM-AS1 predicted poor prognosis in OS patients. Yes In addition, the silencing of DSCAM-AS1 suppressed the viability and invasion of OS cells, while DSCAM-AS1 overexpression promoted cell viability and invasion. 32744697 DSCAM-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells regulation[miR-877-5p/ATXN7L3 axis] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay In this research, our findings presented that DSCAM-AS1 expression was up-regulated in CC cells. Our findings clarified that DSCAM-AS1 played as an oncogenic lncRNA by targeting miR-877-5p/ATXN7L3 axis to promote CC progression, which may provide insights into the prevention of CC. Yes DSCAM-AS1 led to the development of CC by enhancing cell proliferation, migration and invasion ability. 31737900 DSCAM-AS1 LncRNA Homo sapiens Pancreatic Neoplasms tumor tissues and cell lines Interaction(miR-136-5p/PBX3 axis) In Vivo Experiment//Western Blot//ISH//Transfection//qRT-PCR//Luciferase Report Assay//IF Our results showed that DSCAM-AS1 was elevated in tumor tissues of pancreatic cancer patients and cell lines. DSCAM-AS1 could promote PBX3 expression by sponging miR-136-5p, and its function in pancreatic cancer was partially mediated by the miR-136-5p/PBX3 axis. Yes knockdown efficiently inhibited PANC-1 cell proliferation, migration, and invasion and suppressed tumor growth. 35142595 DNM3OS LncRNA Homo sapiens Huntington Disease HD PC12 cells Interaction(miR-196b-5p/GAPDH pathway ) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay Our results show that GAPDH and DNM3OS were upregulated in HD PC12 cells, downregulation of which lead to inhibition of aggregate formation accompanied by a decreased apoptosis rate and increased relative ROS levels and cell viability. Moreover, upregulated DNM3OS decreased the expression of miR-196b-5p by sponging, and GAPDH was a direct target of miR-196b-5p, playing an important pathogenic role in the formation of aggregates in the HD cell model. Yes Our results show that GAPDH and DNM3OS were upregulated in HD PC12 cells, downregulation of which lead to inhibition of aggregate formation accompanied by a decreased apoptosis rate and increased relative ROS levels and cell viability. 34369082 DANCR LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues,cell lines Regulation[miR-135a/NLRP37 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In pancreatic cancer, DANCR was up-regulated while miR-135a was down-regulated. A negative relationship was found between DANCR and miR-135a expression. Moreover, we found that miR-135a reversed the effects of DANCR in the promoting of pancreatic cancer cells, which was achieved by regulating the downstream protein of NLRP3. The correlations among DANCR, miR-135a and NLRP3 were confirmed in animal experiments. Conclusion DANCR promoted proliferation and invasion through the regulating of miR-135a / NLRP3 axis in pancreatic cancer cell. Our results suggest that DANCR may be a potential target for the therapy of pancreatic cancer. Yes The over-expression of DANCR promoted the proliferation and invasion of pancreatic cancer cells. 31267381 DLX6-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-513c/Cul4A/ANXA10 axis] qRT-PCR Our data show that lncRNA DLX6-AS1 and Cul4A were highly expressed, while miR-513c and ANXA10 were poorly expressed in HCC tissues and cells.In vivo experiments verified that lncRNA DLX6-AS1 promoted the progression of HCC through the miR-513c/Cul4A/ANXA10 axis. Yes Moreover, the silencing of lncRNA DLX6-AS1 impeded the viability, invasion, and migration of HCC cells, while stimulating cell apoptosis. 33277615 DLX6-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells regulation[FHL2 ,miR-195-5p] CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay DLX6-AS1 and FHL2 were up-regulated in OC tissues and cells, DLX6-AS1, as an oncogene in OC, accelerated tumor progression by up-regulating FHL2 via mediating miR-195-5p, suggesting that DLX6-AS1 was a hopeful target for the lncRNA-targeted therapy in OC. Yes DLX6-AS1 knockdown inhibited proliferation, migration, and invasion but induced apoptosis of OC cells. 32774164 DLX6-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and bladder cell lines Regulation[Wnt/β-catenin signaling pathway] qRT-PCR//Western Blot Our results showed the up-regulation of DLX6-AS1 in cancerous bladder cancer tissues and bladder cell lines, and high expression of DLX6-AS1 was correlated with advance TNM stage, lymphatic node metastasis and distant metastasis.The results from in vitro and in vivo assays implied that DLX6-AS1 exerted enhanced effects on bladder cancer cell proliferation, invasion and migration partly via modulating EMT and the activity of Wnt/β-catenin signaling pathway. Our results showed the up-regulation of DLX6-AS1 in cancerous bladder cancer tissues and bladder cell lines, and high expression of DLX6-AS1 was correlated with advance TNM stage, lymphatic node metastasis and distant metastasis. Yes The in vitro experimental data showed that DLX6-AS1 overexpression promoted bladder cancer cell growth, proliferation, invasion, migration and epithelial-to-mesenchymal transition (EMT); while DLX6-AS1 inhibition exerted tumor suppressive actions on bladder cancer cells. 31787849 DLX6-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues regulation[miR-195-5p/VEGFA signaling pathway] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP DLX6-AS1 was highly expressed in BC tissues and significant negative correlation with the 5-year survival in the BC patients. Our study demonstrated that DLX6-AS1 played an oncogenic role in BC through miR-195-5p-mediated VEGFA/Ras/Raf/MEK/ERK pathway. DLX6-AS1 was highly expressed in BC tissues and significant negative correlation with the 5-year survival in the BC patients. Yes The results showed that the proliferation, migration and invasion activities of BC cells were promoted by DLX6-AS1 overexpression, while cell apoptosis was repressed. 32756011 DLX6-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and OS cell lines Regulation[miR-641/HOXA9 signaling pathway] qRT-PCR DLX6-AS1 was found to be significantly upregulated in OS tissues and OS cell lines. Our results suggested that DLX6-AS1 functions as a ceRNA by targeting miR-641/HOXA9 signal pathway to suppress OS cell proliferation and metastasis. High expression of DLX6-AS1 was significantly correlated with advanced TNM stage, high tumor grade, and distant metastasis of patients with OS. Yes Knockdown of DLX6-AS1 suppressed OS cell proliferation, invasion, and migration, and induced cell apoptosis. Knockdown of DLX6-AS1 also suppressed in vivo tumor growth. 30838699 DLX6-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Regulation[DLX6-AS1/miR-141-3p axis] RNA Pull-Down//Western Blot//RIP//qRT-PCR//Luciferase Report Assay In conclusion, the knockdown of DLX6-AS1 might suppress OS progression via sponging miR-141-3p and downregulating Rab10, suggesting a novel DLX6-AS1/miR-141-3p/Rab10 pathway in OS progression. Yes Functionally, cell proliferation, migration and invasion were evaluated by utilizing the MTT assay and transwell assays. Xenograft experiments depicted that DLX6-AS1 knockdown restrained the tumor growth of MG-63 cells in vivo. 35528911 DLX6-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues ,cell lines Interaction[targeting miR‑199a] CCK8//qRT-PCR//Luciferase Report Assay In the present study, DLX6‑AS1 expression was identified to be significantly upregulated in cervical cancer tissues and cell lines by reverse transcription‑quantitative polymerase chain reactions.Bioinformatics analysis predicted that micro RNA (miR)‑199a was a direct target of DLX6‑AS1. Yes Knockdown of DLX6‑AS1 inhibited cell proliferation and induced cell apoptosis. Overexpression of miR‑199a counteracted the role of DLX6‑AS1 in facilitating proliferation and inhibiting apoptosis in in vitro rescue assays. 30535431 DLX6-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells regulation[miR-16-5p/ARPP19 Axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Elevated DLX6-AS1 expression was disclosed in CC cells. DLX6-AS1 accelerates the progression of CC through sponging miR-16-5p and upregulates ARPP19, which offers a novel insight into prognosis and remedy of CC. Yes DLX6-AS1 silence attenuated proliferation, migration, and epithelial-mesenchymal transition program as well as enhanced CC cell apoptosis. 32077747 DLX6-AS1 LncRNA Homo sapiens Glioma glioma cells and tissue Interaction[sponging miR-197-5p ] qRT-PCR Here, we demonstrated that DLX6-AS1 expression was both high-expressed in the glioma cells and tissue, and the overexpression of DLX6-AS1 was clinically correlated with the poor outcome of glioma patients. Overall, our finding supports that DLX6-AS1 accelerates the glioma carcinogenesis by competing endogenous sponging miR-197-5p to relieve E2F1, acting as a novel therapeutic target for glioma. Here, we demonstrated that DLX6-AS1 expression was both high-expressed in the glioma cells and tissue, and the overexpression of DLX6-AS1 was clinically correlated with the poor outcome of glioma patients. Yes In the cellular functional assays, silenced DLX6-AS1 expression by siRNAs inhibited the proliferation, invasion and tumor growth in vitro and in vivo, while the enhanced DLX6-AS1 expression by plasmids promotes them. 30366080 DLX6-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction[targeting MiR-199a-5p] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expression of lncRNA DLX6-AS1 was up-regulated in NPC tissues and cells.We found that DLX6-AS1 was a cancer-promoting lncRNA to facilitate the progression of NPC, and its underlying mechanism was suppressing miR-199a-5p expression. This study can provide novel clues for the treatment of NPC. Yes The proliferation, migration, and invasion of NPC were enhanced by overexpressed DLX6-AS1 but inhibited by DLX6-AS1 knockdown. 31782911 DLX6-AS1 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues interaction[miR-181b] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The high expression of DLX6-AS1 was observed in pancreatic cancer tissues, and high expression of DLX6-AS1 was positively correlated with larger tumor size, advanced TNM stage and lymph node metastasis.Collectively, our data suggested that DLX6-AS1 promotes cancer cell proliferation and invasion by attenuating the endogenous function of miR-181b in pancreatic cancer. The high expression of DLX6-AS1 was observed in pancreatic cancer tissues, and high expression of DLX6-AS1 was positively correlated with larger tumor size, advanced TNM stage and lymph node metastasis. Yes Knockdown of DLX6-AS1 dramatically impaired cancer cell proliferation, migration and invasion. 30250401 DLX6-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and PC cell lines Interaction[miR-497-5p/FZD4/FZD6/Wnt/β-catenin pathway] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay We observed that DLX6-AS1 was highly expressed in PC tissues and PC cell lines, and was negatively correlated with the survival of PC patients. Collectively, these findings suggested that DLX6-AS1/miR-497-5p/FZD4/FZD6/Wnt/β-catenin signaling pathway is involved in the pathogenesis of PC, and DLX6-AS1 could be a potential biomarker and target for PC treatment. We observed that DLX6-AS1 was highly expressed in PC tissues and PC cell lines, and was negatively correlated with the survival of PC patients. Yes We found that overexpression of DLX6-AS1 promoted proliferation, migration, and invasion of PC cells, inhibited apoptosis, increased Bcl-2, cyclin D1, and MMP-2 expression, and decreased cleaved caspase 3, p27, and E-cadherin expression in PC cells. In addition, overexpression of DLX6-AS1 promoted PC growth by increasing tumor volume and weight and increasing the number of liver and lung metastatic foci. Knockdown of DLX6-AS1 showed an opposite effect in all the experiments. 31118816 DLX6-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung non-small-cell lung cancer (NSCLC) cell Regulation(wnt/β-catenin pathway) Other In conclusion, the exogenous overexpression of a DLX6-AS1-encoded peptide could facilitate NSCLC cell growth by activating wnt/β-catenin pathway. Yes The exogenous overexpression of this ORF-encoded peptide promoted NSCLC cell proliferation, migration, and invasion. 36017915 DLX6-AS1 LncRNA Homo sapiens Thyroid Neoplasms TC tissues Interaction(miR-193b-3p/HOXA1) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay DLX6-AS1 and HOXA1 were up-regulated, and miR-193b-3p was down-regulated in TC.DLX6-AS1 targeted miR-193b-3p and positively regulated HOXA1. miR-193b-3p inhibition mitigated the impaired tumorigenesis induced by down-regulated DLX6-AS1. Yes Depleted DLX6-AS1 or restored miR-193b-3p disturbed cell growth and promoted autophagy. 34514705 DLX6-AS1 LncRNA Homo sapiens Endometrial Neoplasms endometrial cancer tissues and cells interaction[ p300/E2F1] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//FISH//RIP//CHIP//EdU Staining//Transwell Assay DLX6-AS1 and DLX6 were highly expressed in endometrial cancer tissues and cells, and their silencing weakened the proliferative and invasive abilities of endometrial cancer cells and tumours, while promoting apoptosis. Mechanistic investigations indicated that DLX6-AS1 formed a triplex structure with DLX6 via interaction with p300/E2F1 acetyltransferase. Yes DLX6-AS1 and DLX6 were highly expressed in endometrial cancer tissues and cells, and their silencing weakened the proliferative and invasive abilities of endometrial cancer cells and tumours, while promoting apoptosis. 32951317 DLX6-AS1 LncRNA Homo sapiens Liver Neoplasms liver cancer tissues and cell lines Interaction[targeting miR-424-5p] RNA Pull-Down//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay In this study, we first demonstrated that lncRNA DLX6 antisense RNA 1 (DLX6-AS1) was upregulated in cancer tissues and cells lines compared with normal adjacent and cell line. Taken together, these results suggested that upregulated DLX6-AS1 promoted cell proliferation, migration, and invasion of HCC through increasing expression of WEE1 via targeting miR-424-5p. Yes Knock-down DLX6-AS1 by transfection with small interfering RNA (siRNA) suppressed cell proliferation, migration, and invasion of HCC cells. 30805988 DLX6-AS1 LncRNA Homo sapiens Laryngeal Neoplasms tumor tissues regulation[miR-26a/TRPC3 Pathway] qRT-PCR//Luciferase Report Assay//Western Blot lncRNA DLX6-AS1 had increased expression in tumor tissues compared with adjacent normal tissues and in higher clinical stages compared with lower stages, which was associated with poor prognosis.This study provides new evidence that a novel lncRNA, DLX6-AS1, regulates mitochondrial calcium homeostasis, respiration and tumor proliferation via modulating the miR-26a/TRPC3 axis in laryngeal cancer. ncRNA DLX6-AS1 had increased expression in tumor tissues compared with adjacent normal tissues and in higher clinical stages compared with lower stages, which was associated with poor prognosis. Yes In detail, DLX6-AS1 knockdown decreased cell proliferation and affected key mitochondrial metabolic parameters in both HEp-2 and Tu-177 cells. 32368147 DLX6-AS1 LncRNA Homo sapiens Neuroblastoma NB tissues and cell lines Interaction[miR-107/BDNF pathway] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Microarray//Colony Formation Assay//Transwell Assay The expression of DLX6-AS1 was increased in NB tissues and derived cell lines, and high expression of DLX6-AS1 was positively correlated with advanced TNM stage and poor differentiation.Overall, our finding supports that DLX6-AS1 promotes NB progression by regulating miR-107/BDNF pathway, acting as a novel therapeutic target for NB. The expression of DLX6-AS1 was increased in NB tissues and derived cell lines, and high expression of DLX6-AS1 was positively correlated with advanced TNM stage and poor differentiation. Yes Knockdown of DLX6-AS1 induced neuronal differentiation, apoptosis and inhibited the growth, invasion, and metastasis of NB cells in vitro and impaired tumor growth in vivo. 31787850 DLX6-AS1 LncRNA Homo sapiens Neuroblastoma NB tissues and cells regulation[miR-513c-5p/PLK4 axis] qRT-PCR Our data showed that DLX6-AS1 was significantly overexpressed in NB tissues and cells. Our findings identified a novel regulatory mechanism, the DLX6-AS1/miR-513c-5p/PLK4 axis, in NB progression, highlighting a strong rationale for developing DLX6-AS1 as a new target for NB management. Yes Moreover, DLX6-AS1 silencing repressed NB cell viability, colony formation, migration, and invasion, and promoted cell cycle arrest and apoptosis in vitro, as well as decreased tumor growth in vivo. 33031637 DLX6-AS1 LncRNA Homo sapiens Neuroblastoma NB tissues and cells regulation[STAT2,miR-506-3p] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay DLX6-AS1 expression was highly elevated in NB tissues and cells.DLX6-AS1 regulated cell proliferation, cell cycle and glycolysis in vitro and tumor growth in vivo to promote the development of NB by upregulating STAT2 via targeting miR-506-3p. Yes DLX6-AS1 deficiency inhibited NB cell proliferation, cell cycle and glycolysis in vitro.Moreover, DLX6-AS1 deficiency weakened tumor growth in vivo. 32904436 DLX6-AS1 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues and cells Regulation[Notch signaling pathway] qRT-PCR//Western Blot We first verified the increased expression of DLX6-AS1 in EOC patient samples and cell lines.Mechanistic studies revealed that the knockdown of DLX6-AS1 down-regulated Notch1, p21, and Hes1, indicating that the activity of the Notch signaling pathway was inhibited. Clinical assays indicated that high DLX6-AS1 was significantly associated with FIGO stage, lymph node metastasis and poor prognosis. Furthermore, multivariate Cox regression analysis confirmed DLX6-AS1 as an independent prognostic factor in EOC patients. Yes Functionally, the down-regulation of DLX6-AS1 decreased EOC cells proliferation, migration, invasion and induced cell cycle G1/S phase arrest and cell apoptosis. 31081076 DNAJC3-DT LncRNA Homo sapiens Colonic Neoplasms colon cancer cells regulation[miR-214-3p/LIVIN axis] Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The highest level of DNAJC3-AS1 was found in LoVo cells, followed by Caco-2 cells (Figure 1(a)). These findings suggested that DNAJC3-AS1 may promote colon cancer progression by regulating the miR-214-3p/LIVIN axis. Yes We found that the down-regulation of DNAJC3-AS1 inhibited the proliferation of colon cancer cells and induced growth arrest. Down-regulation of DNAJC3-AS1 also inhibited the migration, invasion, and epithelial-mesenchymal transition (EMT) of colon cancer cells. 32352854 DLX6-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[PI3K/AKT/mTOR pathway] CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay DLX6-AS1 was up-regulated in 60 CRC tissues when compared to normal adjacent colorectal tissues.In summary, our data indicated that DLX6-AS1 promoted CRC cell proliferation, invasion, and migration but inhibited cell apoptosis via targeting PI3K/AKT/mTOR signalling pathway, suggesting the key role of DLX6-AS1 in CRC progression. DLX6-AS1 was up-regulated in 60 CRC tissues when compared to normal adjacent colorectal tissues, and high expression of DLX6-AS1 was correlated with advanced T stage and distant metastasis in CRC patients. Yes The gain-of-function assays showed that DLX6-AS1 overexpression promoted HCT116 cell proliferation, invasion, and migration, but inhibited cell apoptosis; while the loss-of-function assays showed that DLX6-AS1 knockdown exerted the opposite effects in SW480 cells. In vivo studies revealed that DLX6-AS1 knockdown suppressed tumor growth in the nude mice xenograft model. 31646562 DNAJC3-DT LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cell lines Interaction(miR-27a-3p/PRDM14 axis) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Invasion Assay The expression of DNAJC3-AS1 was upregulated in ccRCC tissues and cell lines compared to their normal counterparts. Moreover, we also found that DNAJC3-AS1 acted as a sponge of miR-27a-3p and identified PRDM14 as a target of miR-27a-3p. Yes In vitro, silencing DNAJC3-AS1 reduced the proliferation, migration and invasion of ccRCC cells. Downregulation of DNAJC3-AS1 also led to the apoptosis of ccRCC cells. 33629299 DNAJC3-DT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-27b ) BrdU//qRT-PCR//RNA Pull-Down DNAJC3-AS1 was overexpressed in HCC and predicts the poor survival. MiR-27b was downregulated at mature miRNA level, but upregulated at premature level. DNAJC3-AS1 directly interacted with premature miR-27b and was localized to both nuclear and cytoplasm. DNAJC3-AS1 overexpression upregulated premature miR-27b and downregulated mature miR-27b, while DNAJC3-AS1 knockdown led to the opposite results. Yes DNAJC3-AS1 suppressed the role of miR-27b in inhibiting cell proliferation. 34815712 DNAH17-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC specimens and cell lines regulation[miR-877-5p/CCNA2 pathway] qRT-PCR We observed that the expression of DNAH17-AS1 and CCNA2 mRNA was distinctly upregulated in NSCLC specimens and cell lines, while miR-877-5p expression was significantly decreased.Overall, we identified a novel NSCLC-related lncRNA, DNAH17-AS1 which may exert an oncogenic function via serving as a sponge for miR-877-5p to upregulate CCNA2. Clinical assays revealed that high DNAH17-AS1 was associated with TNM stage, distant metastasis and shorter overall survival and disease-free survival. Yes Functional assays indicated that knockdown of DNAH17-AS1 suppressed the proliferation, migration and invasion of H1299 and 95D cells, and promoted apoptosis. 32981678 DNAH17-AS1 LncRNA Homo sapiens Pancreatic Carcinoma PC cells regulation[ miR-432-5p/PPME1 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay DNAH17-AS1 was upregulated in PC cells and was associated with aggressive tumor behavior and poor prognosis for patients. DNAH17-AS1 was upregulated in PC cells and was associated with aggressive tumor behavior and poor prognosis for patients. DNAH17-AS1 functions in PC as a tumor promoter by regulating the miR-432-5p/PPME1 axis. Yes Silencing DNAH17-AS1 promoted the apoptosis and reduced the viability, invasion, and migration of PC cells. 32351291 DNACR LncRNA Homo sapiens Osteosarcoma osteosarcoma tissue and cell lines Interaction[regulating miR-216a-5p] Flow Cytometry//qRT-PCR//Western Blot//Transwell Assay We found that a significantly elevated of DNACR was detected in osteosarcoma tissue and cell lines.DANCR was a sponge of miR-216a-5p activity. DANCR regulated survival of osteosarcoma through targeting miR-216a-5p. Additionally, SOX5 was a direct target of miR-216a-5p, overexpression miR-216a-5p exerted inhibition effects via down-regulating SOX5 expression. Furthermore, DANCR regulated SOX5 expression by sponging to miR-216a-5p. In conclusion, LncRNA DANCR silence inhibits SOX5-medicated progression and autophagy in osteosarcoma via regulating miR-216a-5p which indicating DANCR may act as a potential prognostic biomarker and therapeutic target for osteosarcoma. Yes Functional experiments suggested that down-regulation of DANCR inhibited cells proliferation, migration, invasion and autophagy but induced apoptosis in osteosarcoma in vitro.Additionally, we also determined knockdown of DANCR inhibited the growth and autophagy of osteosarcoma in vivo. 31918278 DMTF1v4 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissue Expression[highly expressed] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay Compared with para-carcinoma tissue, lncRNA DMTF1v4 in colon cancer tissue was highly expressed (p<0.001). Yes Downregulating lncRNA DMTF1v4 in HT-29 cells showed that lncRNA DMTF1v4 promotes cell proliferation and migration, and suppresses apoptosis (p<0.05). 29949153 DMTF1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-17-5p/SRSF2 Axis] qRT-PCR The results showed that MRUL was overexpressed in NSCLC samples and correlated with the poor prognosis of patients who had NSCLC. By combining bioinformatics analysis and experimental validation, we found that MRUL regulated NSCLC progression through promoting SRSF2 by sponging miR-17 in NSCLC cells. The results showed that MRUL was overexpressed in NSCLC samples and correlated with the poor prognosis of patients who had NSCLC. Yes Knockdown of MRUL considerably repressed NSCLC cell proliferation, invasion, and migration. 33123591 DMTF1 LncRNA Homo sapiens Osteosarcoma cancer tissues and cell lines regulation[ miR-125a-5p/FUT4 Axis] qRT-PCR We found that lncRNA MRUL was up-regulated in cancer tissues and cell lines. In conclusion, these results demonstrated that OS-upregulated lncRNA MRUL promoted cell proliferation, and metastasis via negatively regulating miR-125a-5p, and imply that lncRNA MRUL may be a potential biomarker for OS. Yes Functional experiments showed that knockdown of lncRNA MRUL inhibited OS cell proliferation, and metastasis. 32670359 DLX6-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay The data revealed that the expression of DLX6-AS1 was significantly upregulated in GC tissues compared with adjacent paired noncancerous tissues. Furthermore, the expression of DLX6-AS1 was higher in advanced GC tissue samples (III/IV) compared with the expression in early-stage samples (I/II). Furthermore, the current study demonstrated that a high expression of DLX6-AS1 was significantly associated with advanced clinical stage, lymph node metastasis and distant metastasis. Yes In vitro experimental data indicated that DLX6-AS1 was upregulated in GC cell lines and that the inhibition of DLX6-AS1 markedly reduced GC cell proliferation, colony formation, cell cycle progression, migration and invasion. Further investigation revealed that knockdown of DLX6-AS1 inhibited EMT in GC cells. 31105791 DLX6-AS1 LncRNA Homo sapiens Stomach Neoplasms cell lines Interaction[FUS-regulated MAP4K1] Western Blot//CCK8//qRT-PCR//RIP//Colony Formation Assay//Transwell Assay Firstly, we measured DLX6-AS1 expression in GC and then found the elevated level of DLX6-AS1.In summary, DLX6-AS1 modulated GC progression through FUS-regulated MAP4K1. Yes The silencing of DLX6-AS1 suppressed cell proliferation, migration and EMT process of GC cells. 31591939 DLX6-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Regulation[ miR-204-5p/OCT1 axis ] qRT-PCR//ChIP//Luciferase Report Assay//Western Blot We first demonstrated that DLX6-AS1 was upregulated in GC tissues and cell lines and was associated with T3/T4 invasion, distant metastasis and poor clinical prognosis.This study revealed that OCT1-induced DLX6-AS1 promoted GC progression and the EMT via the miR-204-5p/OCT1 axis, suggesting that this lncRNA might be a promising prognostic biomarker and therapeutic target for GC. We first demonstrated that DLX6-AS1 was upregulated in GC tissues and cell lines and was associated with T3/T4 invasion, distant metastasis and poor clinical prognosis. Yes Further functional analysis showed that downregulation of DLX6-AS1 inhibited GC cell proliferation, migration, invasion and EMT in vitro. 31463827 DLX6-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines interaction[Targeting microRNA-4290] qRT-PCR DLX6-AS1 was overexpressed in GC tissues and cell lines. LncRNA DLX6-AS1 regulated tumor growth and aerobic glycolysis in GC by targeting miR-4290 and PDK1, suggesting DLX6-AS1 might serve as a novel potential therapeutic target for GC treatment from bench to clinic. Yes DLX6-AS1 knockdown by short hairpin RNA (shRNA) significantly inhibited cell viability and colony formation, and induced apoptosis. DLX6-AS1 silencing impaired aerobic glycolysis but stimulated mitochondrial respiration in GC cells. 32239379 DLX6-AS1 LncRNA Homo sapiens Breast Neoplasms bladder cancer tissues Regulation[miR-505-3p/RUNX2 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay In the current study, the expression of DLX6-AS1 in the BC tissue samples was evaluated and the correlation between DLX6-AS1 expression and clinicopathological parameters were also analyzed. Moreover, luciferase reporter assay validated that DLX6-AS1 acted as an endogenous sponge to miR-505-3p and negatively regulated its expression. Additionally, miR-505-3p inhibited runt-related transcription factor 2 (RUNX2) expression by directly bind to its 3'- untranslated region (3'-UTR) and overexpression of RUNX2 partially reversed the effect of miR-505-3p mimics on BC cell proliferation and invasion. Furthermore, in BC tissues, miR-505-3p expression level was inversely associated with DLX6-AS1 and RUNX2, respectively. In conclusion, these findings demonstrated that DLX6-AS1 functioned as an oncogenic role that promoted BC proliferation and invasion through miR-505-3p/RUNX2 axis, which might serve as a potential therapeutic target for BC treatment. We found that DLX6-AS1 expression was much higher in tumor tissues than that in adjacent normal tissues and was positively associated with poor prognosis in BC patients. Yes DLX6-AS1 knockdown significantly suppressed BC cell proliferation, invasion, migration, and promoted apoptosis. 31705901 DLX6-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[downregulating PRR11 expression and upregulating miR-144] qRT-PCR//MTT//Luciferase Report Assay//Western Blot DLX6-AS1 and PRR11 were elevated in NSCLC tissues and cells. In addition, DLX6-AS1 and PRR11 were demonstrated to interact with microRNA-144 (miR-144) and DLX6-AS1 upregulated PRR11 expression by acting as a competing endogenous RNA (ceRNA) of miR-144 in NSCLC cells. Furthermore, DLX6-AS1 knockdown suppressed tumor growth in NSCLC in vivo by upregulating miR-144 and downregulating PRR11. Yes Knockdown of DLX6-AS1 and PRR11 significantly suppressed cell proliferation, migration and invasion and induced apoptosis in NSCLC cells, which was reversed by PRR11 overexpression. 30551440 DLX6-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation[miR-27b-3p/ GSPT1 axis] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay DLX6-AS1 was over-expressed in NSCLC tumor tissues and cell lines and its level of expression was found to be associated with tumor size and advanced clinical stage in patients with NSCLC.DLX6-AS1 was found to interact with miR-27b-3p/GSPT1. DLX6-AS1 expression was negatively correlated with miR-27b-3p expression, but positively correlated with GSPT1 expression in NSCLC samples. DLX6-AS1 knockdown also effectively suppressed tumor growth in an in vivo xenograft model. Conclusion: DLX6-AS1 regulated NSCLC progression by targeting the miR-27b-3p/GSPT1 axis, which may provide novel insights for NSCLC prognosis and therapy. DLX6-AS1 was over-expressed in NSCLC tumor tissues and cell lines and its level of expression was found to be associated with tumor size and advanced clinical stage in patients with NSCLC. Yes Downregulation of DLX6-AS1 inhibited cell proliferation, cell clone formation, migration, and invasion of NSCLC cells. 31190891 DLX6-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,blood,cell lines Expression[highly expressed] qRT-PCR First, it was revealed that the expression levels of DLX6-AS1 were significantly increased in tumor tissues compared with in adjacent normal tissues. In addition, DLX6-AS1 was highly expressed in NSCLC cell lines compared with in BEAS-2B cells. It was subsequently demonstrated that the serum DLX6-AS1 level was significantly higher in patients with NSCLC compared with in healthy controls. Additionally, the higher DLX6-AS1 expression was associated with advanced disease stage, positive lymph node metastasis and poor tumor differentiation of NSCLC. ROC analysis demonstrated that the sensitivity and specificity of DLX6-AS1 were higher than those of CYFRA21-1, which is a serum marker for NSCLC. Yes DLX6-AS1-knockdown inhibited cell proliferation and migration in vitro. 31612030 DLX6-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells  Interaction(miR-16-5p/BMI1 axis) IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay DLX6-AS1 was overexpressed in NSCLC tissues and cells, and was inextricably linked with the poor prognosis of NSCLC patients. Yes Depletion of DLX6-AS1 oppressed cell proliferation, migration, invasion, epithelial-mesenchymal transition (EMT) but promoted apoptosis in NSCLC. 35116677 DLX6-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma Expression[highly expressed] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay Compared with the paired adjacent noncancerous tissues, DLX6‑AS1 expression was upregulated in the ESCC tissues and significantly associated with differentiation status, Tumor‑Node‑Metastasis stage, distant metastasis, and lymph node metastasis. Compared with the paired adjacent noncancerous tissues, DLX6‑AS1 expression was upregulated in the ESCC tissues and significantly associated with differentiation status, Tumor‑Node‑Metastasis stage, distant metastasis, and lymph node metastasis. Yes Knockdown of DLX6‑AS1 significantly suppressed cell proliferation, invasion and migration abilities, and enhanced the apoptotic rate in the two ESCC cell lines. 30592268 DUXAP10 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(SOX18) Invasion Assay//Migration Assay//qRT-PCR//MTT//Colony Formation Assay//EdU Staining In this study, we identified an lncRNA called DUXAP10 by analysis of GEO data, which was significantly up-regulated in OS tissues and cell lines. Mechanistically, DUXAP10 mainly localized in cytoplasm and could specifically bind to HuR to increase the stability of SOX18 mRNA. Meanwhile, SOX18 knockdown largely reversed increased proliferation of OS cells induced by DUXAP10 overexpression. Yes Experiments in vitro revealed that lncRNA DUXAP10 promoted proliferation, migration, and invasion of OS cells and inhibited their apoptosis. We also demonstrated that DUXAP10 promoted the formation and growth of OS by tumor formation assay. 36053455 DUXAP10 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Regulation[ Wnt/β-catenin and PI3K/Akt signaling pathways ] Western Blot//CCK8//qRT-PCR//MTT//Transwell Assay The results showed that DUXAP10 is dramatically elevated in HCC tumor tissues and cell lines. Collectively, DUXAP10 plays a critical role in regulating HCC development, potentially by regulating EMT and cell proliferation through the PI3K/Akt and Wnt/β-catenin signaling. Yes Knockdown of DUXAP10 by DUXAP10 si-RNA significantly inhibited the cell viability, proliferation and induce the apoptosis of HCC cell line. 30996112 DUXAP10 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines Expression[highly expressed] qRT-PCR//Western Blot The data from TCGA showed that the expression of DUXAP10 was upregulated in tissues of RCC compared with normal tissues. Moreover, ONCOMINE database analysis indicated that high DUXAP10 levels were correlated with high clinical stages, inferior TNM classification, and poor overall survival. Yes Furthermore, the results indicated that knockdown of DUXAP10 remarkably inhibited the RCC cell growth, mobility, and invasion, in association with the upregulation of E-cadherin and downregulation of cyclin D, cyclin E, CDK4, N-cadherin, and vimentin. 33215419 EIF1AX-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC cell Interaction(EIF1AX/PCBP1) In Vivo Experiment//Western Blot//Flow Cytometry//FISH//qRT-PCR//RNA-seq//IHC Here, using RNA sequencing analysis, we systemically screened and identified the lncRNA eukaryotic translation initiation factor 1A, X-linked (EIF1AX)-AS1, which is aberrantly downregulated in clinical EC tissues and closely correlated with tumor type.Mechanistically, EIF1AX-AS1 interacts with EIF1AX mRNA and poly C binding protein 1 (PCBP1), which promote EIF1AX mRNA degradation. Intriguingly, by interacting with internal ribosome entry site-related protein Y-box binding protein 1 (YBX-1), EIF1AX promotes c-Myc translation through the internal ribosome entry site pathway. c-Myc promotes EIF1AX transcription and thus forms a feed-forward loop to regulate EC cell proliferation. Yes EIF1AX-AS1 markedly inhibited EC cell proliferation and promoted apoptosis in vitro and in vivo. 35080085 EGOT LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines regulation[Hedgehog pathway] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay We observed that EGOT is significantly down-regulated in breast cancer tissues and cell lines, and EGOT expression is negatively correlated with the Ki67 expression. We conclude that lncRNA EGOT may inhibit breast cancer cell viability and migration via inactivation of the Hh pathway. Yes Overexpression of EGOT in BT549 cells decreased cell viability and migration. 32150666 EGOT LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-33b-5p/CROT axis] qRT-PCR Data from this study revealed that EGOT expression was obviously upregulated in CRC tissues and cell lines, and high EGOT expression indicated poor overall survival of CRC patients. In conclusion, lncRNA EGOT mediates the tumor-facilitating part in CRC via miR-33b-5p/CROT pathway. Data from this study revealed that EGOT expression was obviously upregulated in CRC tissues and cell lines, and high EGOT expression indicated poor overall survival of CRC patients. Yes Besides, functional assays proved that EGOT knockdown inhibited cell proliferation and promoted cell apoptosis in CRC. 32373939 EGOT LncRNA Homo sapiens Colonic Neoplasms Colon Cancer tissues,blood interaction[microRNA-33a-5p and microRNA-33b-5p] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The online database and qRT-PCR detection showed that EGOT was highly expression in patients with CC and had good diagnostic value. However, the tumor in nude mice was significantly lessened after knockout of EGOT. Bioinformatic analysis showed that microRNA-33a-5p and microRNA-33b-5p had targeted binding sites with EGOT. The five-year survival rate of patients with high expression of EGOT decreased. EGOT and TNM staging were independent prognostic factors of patients with CC. Yes Functional analysis revealed that the growth and invasion abilities of cells increased, and the apoptosis rate decreased after overexpression. Upregulation of EGOT inhibited autophagy of CC cells and promoted cell growth. 33408522 EGLN3 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines interaction[IRF7 ,miR-1299] qPCR//PCR The results indicated that circ-EGLN3 was elevated in RCC tissues and cell lines and predicted unfavorable prognosis for the patients with RCC.Collectively, our study suggested that circ-EGLN3 knockdown suppressed RCC progression through acting as a ceRNA to regulate the IRF7 expression by targeting miR-1299. Yes Silenced circ-EGLN3 hindered cell proliferation, migration, and invasion but facilitated apoptosis of RCC cells. 31904147 EGLN3 CircRNA Homo sapiens Carcinoma, Renal Cell RCC cells and tissues Interaction(miR-1224-3p/HMGXB3 axis) Western Blot//Transfection//qRT-PCR//PCR//IF circ-EGNL3 acts as a sponge for miR-1224-3p, which targeted HMGXB3. Circ-EGNL3 indirectly upregulated HMGXB3 by targeting miR-1224-3p, and overexpression of circ-EGLN3 reversed the repressive effects of miR-1224-3p on RCC. Circ-EGLN3 was upregulated in RCC cells and tissues and correlated with poor overall survival. Yes "Silencing of circ-EGNL3 decreased RCC cell proliferation, migration, and invasion. Mechanistic studies indicated that circ-EGNL3 acts as a sponge for miR-1224-3p, which targeted HMGXB3. Circ-EGNL3 indirectly upregulated HMGXB3 by targeting miR-1224-3p, and overexpression of circ-EGLN3 reversed the repressive effects of miR-1224-3p on RCC. " 34274607 EGFR-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Regulation[EGFR expression] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//EdU Staining In our study, EGFR-AS1 significantly up-regulated in GC tissues and correlated with tumor size. Mechanismly, depletion of EGFR-AS1 was found to decrease EGFR expression by reduction of EGFR mRNA stability. In our study, EGFR-AS1 significantly up-regulated in GC tissues and correlated with tumor size. Yes Moreover, knock-down of EGFR-AS1 inhibited the proliferation of GC cells via suppressing EGFR-dependent PI3K/AKT pathway in vitro and in vivo. 30138934 EGFR-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction[Sponging miR-145 ] Transwell Assay//qRT-PCR//Luciferase Report Assay//Western Blot Their data showed that EGFR-AS1 and ROCK1 were upregulated in ESCC and positively correlated. Therefore, EGFR-AS1 may upregulate ROCK1 by sponging miR-145 to promote ESCC cell invasion and migration. Survival analysis showed that high EGFR-AS1 and ROCK1 expression levels predicted poor survival. Yes In esophageal squamous cell carcinoma (ESCC) cells, EGFR-AS1 and ROCK1 overexpression mediated the increased rates of ECSS cell invasion and migration. 31702393 EGFR-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues interaction[micorRNA-381,ROCK2 ] qRT-PCR//Transwell Assay//Western Blot It was revealed that epidermal growth factor receptor-antisense RNA 1 (EGFR-AS1) was upregulated in BC and positively associated with rho associated coiled-coil containing protein kinase 2 (ROCK2). Therefore, EGFR-AS1 may sponge miR-381 to upregulate ROCK2 in BC, thereby promoting cell invasion and migration. Analysis of data collected in follow-ups indicated that EGFR-AS1 expression was significantly associated with poorer overall survival of patients with BC. Yes In addition, EGFR-AS1 and ROCK2 overexpression resulted in the promotion of cell invasiveness and migration of HT-1197 BC cells. 32194685 EGFR-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cell lines Interaction(miR-2355-5p/ACTN4-mediated WNT pathway) RNA Pull-Down//Western Blot//Transfection//Invasion Assay//Tunel//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay EGFR-AS1 was notably overexpressed in CC cell lines. Mechanistically, up-regulation of EGFR-AS1 was attributed to the activation of H3K27 acetylation (H3K27ac). Further, EGFR-AS1 was revealed to function as miR-2355-5p sponge. Additionally, miR-2355-5p was down-regulated in CC cells and ACTN4 was identified as a target gene of miR-2355-5p. Ultimately, overexpressed ACTN4 could reserve the suppressive role of EGFR-AS1 silencing in CC cell growth. Last but not least, EGFR-AS1 facilitated CC cell growth via ACTN4-mediated WNT pathway. Yes Loss-of-functional experiments revealed that EGFR-AS1 promoted CC cell proliferation, migration and invasion, and suppressed cell apoptosis. Ultimately, overexpressed ACTN4 could reserve the suppressive role of EGFR-AS1 silencing in CC cell growth. Last but not least, EGFR-AS1 facilitated CC cell growth via ACTN4-mediated WNT pathway. 34998421 EGFR-AS1 LncRNA Homo sapiens Glioma glioma cells and tissues Interaction[miR-133b/RACK1 ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC The results indicated that lnc-EGFR-AS1 expression was increased in glioma cells and tissues.These findings elucidated that EGFR-AS1 accelerated cell proliferation, migration, invasion and prevented apoptosis in glioma cells by regulating miR-133b/RACK1, providing new insights for the diagnosis and molecular therapy of GBM. Yes EGFR-AS1 knockdown suppressed proliferation, migration and invasion of glioma cells, but induced apoptosis. Additionally, lnc-EGFR-AS1 functioned as a sponge for miR-133b. 31545240 EGFR-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR It was found that EGFR?AS1 was abnormally upregulated in NSCLC tissues compared with adjacent normal lung tissues. Furthermore, patients with NSCLC with increased expression of EGFR?AS1 had a poor prognosis. Yes EGFR?AS1 knockdown significantly inhibited NSCLC malignancy in vitro, including cell proliferation and chemoresistance. 30431074 EGFR-AS1 LncRNA Homo sapiens Kidney Neoplasms RCC tissues Expression[highly expressed] qRT-PCR//RNA Pull-Down In our validation cohort (n = 204), EGFR-AS1 was significantly upregulated in RCC tissues (P < 0.001). Multivariate analysis suggested that higher EGFR-AS1 expression predicted a poor prognosis in RCC patients (high vs low: P = 0.018, HR = 2.204, 95% CI: 1.145-4.241). Yes Gain-of-function and loss-of-function studies showed that EGFR-AS1 promoted cell proliferation and invasion in vitro and in vivo. 30770799 EGFEM1P LncRNA Homo sapiens Thyroid Neoplasms papillary thyroid tumors and thyroid cancer cells Interaction(miR-369-3p/TCF4 axis) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Bioinformatics Analysis The results demonstrated that EGFEM1P was upregulated in papillary thyroid tumors and thyroid cancer cells compared with normal adjacent tissues and human normal thyroid epithelial Nthy-ori 3-1 cell line. In the examined thyroid cancer cells, EGFEM1P was demonstrated to interact with miR-369-3p and decreased miR-369-3p expression levels. Thereafter, TCF4 was determined to be a target gene of miR-369-3p and EGFEM1P promoted TCF4 expression via regulating miR-369-3p expression levels. Yes At last, it was found that EGFEM1P expression promoted rapid cell proliferation and inhibited cell apoptosis in thyroid cancer cells via acting as a miR-369-3p sponge. 36380872 EFNA1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[ eIF4B] qRT-PCR We found that lncRNA-GMAN was significantly overexpressed in HCC tissues.The results demonstrated the stability of p-eIF4B and the elevation of mRNA translation and anti-apoptosis-related protein expression, which further induced proliferation and metastasis of HCC. GMAN expression is associated with vascular invasion, histological grade, tumor, node, metastasis (TNM) stage, short overall survival, and disease-free survival. Yes Knockdown of GMAN induced apoptosis and suppressed invasive and migration potential in vitro and vivo, whereas ectopic GMAN expression produced the opposite effect. 31875526 EBLN3P LncRNA Homo sapiens Colorectal Neoplasms Ninety-five paired CRC tissue samples Interaction( miR-323a-3p) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay EBLN3P was highly expressed in CRC, and its high expression was distinctly associated with increased tumor size, histology/differentiation and advanced TNM stage, and poor clinical outcome of CRC patients. Mechanistically, overexpression of EBLN3P exhibited tumorigenic effects through downregulating the inhibitory effects of miR-323a-3p on UHMK1 expression. EBLN3P was highly expressed in CRC, and its high expression was distinctly associated with increased tumor size, histology/differentiation and advanced TNM stage, and poor clinical outcome of CRC patients Yes EBLN3P silencing significantly inhibited the proliferation and metastasis and induced the apoptosis of CRC cells. 34109193 EBLN3P LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Interaction(miR-224-5p/Rab10 signaling axis) CCK8//qRT-PCR The increased expression of EBLN3P and Rab10 and decreased expression of miR-224-5p were observed in osteosarcoma tissues and cell lines.Bioinformatics analysis and luciferase assay revealed that EBLN3P could directly interacted with miR-224-5p to attenuate miR-224-5p binding to the Rab10 3'-untranslated region. Furthermore, the mechanistic investigations revealed activation of the miR-224-5p/Rab10 regulatory loop by knockdown of miR-372-3p or overexpression of Rab10, thereby confirming the in vitro role of EBLN3P in promoting osteosarcoma cell proliferation, migration and invasion. Yes Besides, the overexpression of EBLN3P or knockdown of miR-224-5p were revealed to promote the proliferation, migration and invasion of osteosarcoma cells. 33479458 EBLN3P LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cell lines Interaction( miR-655-3p/Bcl-2 axis) Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay//Bioinformatics Analysis The results revealed that EBLN3P was upregulated, whereas miR-655-3p was downregulated in LUAD cell lines (A549 and NCI-H23).Bioinformatics analysis and dual-luciferase reporter assays indicated that EBLN3P interacted with miR-655-3p. Mechanistically, miR-655-3p inhibits cell viability and induces apoptosis by inhibiting Bcl-2 expression. The high expression of Bcl-2 reversed the impact of miR-655-3p on the inhibition of cell bioactivity and induction of apoptosis in A549 cells. Yes Knockdown of EBLN3P notably inhibited the bioactivity and induced apoptosis in A549 cells by upregulating miR-655-3p. 35473552 EBLN3P LncRNA Homo sapiens Liver Neoplasms regulation[microRNA-144-3p/DOCK4 Signal] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The present study is the first to demonstrate that EBLN3P may act as a ceRNA to modulate DOCK4 expression by competitively sponging miR-144-3p, leading to the regulation of liver cancer progression, which provides new insights for liver cancer diagnosis and treatment. Yes The present results revealed that overexpression of EBLN3P or knockdown of miR-144-3p promoted liver cancer cell proliferation, migration and invasion. 33061623 EBLN3P LncRNA Homo sapiens T-cell acute lymphoblastic leukemia human T-ALL cell lines Interaction(miR-655-3p) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay The expression of lncRNA EBLN3P was upregulated while that of miR-655-3p was downregulated in human T-ALL cell lines and lncRNA EBLN3P negatively regulated miR-655-3p. Yes LncRNA EBLN3P knockdown significantly inhibited proliferation, invasion, and migration of Jurkat cells and induced their apoptosis. Downregulating miR-655-3p reversed the effects of lncRNA EBLN3P knockdown on Jurkat cells. 35220878 EGOT LncRNA Homo sapiens Stomach Neoplasms GC tissue,cell lines Interaction[Hedgehog Pathway ] CCK8//qRT-PCR//Flow Cytometry//Western Blot The expression of EGOT was observably elevated in GC. Moreover, EGOT mediated cyclin D1 expression in GC cells which was regulated by Hedgehog pathway. Further, loss of EGOT downregulated Hedgehog signaling pathway in GC cells. EGOT functions as an oncogene in GC, and may be useful as a conceivable diagnostic and prognostic biomarker for GC tumorigenesis. Upregulation of EGOT was related with lymphatic metastasis and TNM stage. Yes In addition, knockdown of EGOT by siRNA could significantly inhibit GC cell proliferation and arrest cycle progression in G1 phase. 29209988 EIF3J-DT LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(EIF3J-AS1/MAFG) qRT-PCR//Western Blot//Invasion Assay//Migration Assay In this study, we investigated the high level of EIF3J-AS1 in PCa tissues and cells, and used functional assays to show that knocking down EIF3J-AS1 inhibited PCa cell proliferation and metastatic ability. A preliminary mechanistic investigation also showed that EIF3J-AS1 may increase the expression of MAF bZIP transcription Factor G (MAFG) in PCa. The expression correlation between EIF3J-AS1 and MAFG was found to be positive in PCa tissues. Yes In this study, we investigated the high level of EIF3J-AS1 in PCa tissues and cells, and used functional assays to show that knocking down EIF3J-AS1 inhibited PCa cell proliferation and metastatic ability. 34976178 DUXAP10 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells interaction[p21] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//ChIP In this study, DUXAP10 was certified to be upregulated in ESCC tissues and cells.Results of mechanism experiments suggested that DUXAP10 motivated ESCC progression through recruiting enhancer of zeste homolog 2 (EZH2) to the promoter of p21. Besides, it was positively correlated with short survival time. Yes Moreover, down-expression of DUXAP10 contributed to decreased cell proliferation and metastasis. Silenced DUXAP10 led to increased apoptosis rate and stagnation of cell cycle. 30215547 EIF3J-DT LncRNA Homo sapiens Esophageal Neoplasms Eca tissues interaction[sponging miR-373-3p] CCK8//qRT-PCR//RIP//Transwell Assay Here, we show that EIF3J-AS1 is up-regulated in ECa and that its expression correlates with advanced TNM stage (P = 0.014), invasion depth (P = 0.001), positive lymph node metastasis (P < 0.001) and poor survival (OS: P = 0.0059; DFS: P = 0.0037) in ECa. Overall, EIF3J-AS1 may exhibit an oncogenic function in ECa via acting as a sponge for miR-373-3p to up-regulate AKT1 mRNA level, and may serve as a potential therapeutic target and a prognostic biomarker for ECa patients. Here, we show that EIF3J-AS1 is up-regulated in ECa and that its expression correlates with advanced TNM stage (P = 0.014), invasion depth (P = 0.001), positive lymph node metastasis (P < 0.001) and poor survival (OS: P = 0.0059; DFS: P = 0.0037) in ECa. Yes Functional experiments showed that knockdown EIF3J-AS1 inhibited ECa growth and metastasis through in vitro and in vivo experiments. 32811869 ELFN1-AS1 LncRNA Homo sapiens Colonic Neoplasms CC cells and tissues Interaction( ELFN1-AS1/miR-4270/AURKB axis) qRT-PCR//RIP//Western Blot It was found that AURKB and ELFN1-AS1 expression was upregulated, whereas miR-4270 was downregulated in CC cells and tissues. MiR-4270 was predicted to be a target of ELFN1-AS1 and AURKB as a target of miR-4270. Their interactions were further elucidated using luciferase reporter and RNA RIP assays. More importantly, treatment with a miR-4270 inhibitor not only rescued the tumor-suppressing effect of ELFN1-AS1 silencing but also abrogated the tumor suppressor functions of AURKB silencing in CC cells. Taken together, the ELFN1-AS1/miR-4270/AURKB axis facilitates CC tumorigenesis; therefore, targeting this axis might be a promising intervention in preventing CC progression. Yes ELFN1-AS1 silencing exhibited anti-proliferative, anti-migratory, and pro-apoptotic effects in CC cells. The tumor-suppressive effect of ELFN1-AS1 silencing was verified using in vivo assays. 36561847 ELFN1-AS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer cells Interaction(miR-191-5p/TRIM14 ) Western Blot//Invasion Assay//CCK8//FISH//Luciferase Report Assay//Bioinformatics Analysis MiR-191-5p contains a binding sequence with ELFN1-AS1 and is downregulated by ELFN1-AS1 in colon cancer cells. The expression of TRIM14 is inhibited by ELFN1-AS1 siRNA or miR-191-5p mimics in LoVo and HT29 cells. The treatment of the miR-191-5p inhibitor in ELFN1-AS1 knockdown cells can significantly increase cell proliferation and invasion ability. Overexpression of TRIM14 in miR-191-5p-mimic-treated cells can rescue the inhibition of proliferation and invasion caused by miR-191-5p mimics. Yes The expression of TRIM14 is inhibited by ELFN1-AS1 siRNA or miR-191-5p mimics in LoVo and HT29 cells. The treatment of the miR-191-5p inhibitor in ELFN1-AS1 knockdown cells can significantly increase cell proliferation and invasion ability. Overexpression of TRIM14 in miR-191-5p-mimic-treated cells can rescue the inhibition of proliferation and invasion caused by miR-191-5p mimics. 35652045 ELFN1-AS1 LncRNA Homo sapiens Ovarian Neoplasms OV tissues and cell lines regulation[miR-497-3p/CLDN4 axis ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that ELFN1-AS1 was significantly upregulated in OV tissues and cell lines. Taken together, our findings indicated that ELFN1-AS1 acted as an oncogene in ovarian cancer through regulating the expression of CLDN4 by directly interacting with miR-497-3p. High expression of ELFN1-AS1 was associated with poor prognosis in OV patients. Yes Knockdown of ELFN1-AS1 inhibited the proliferation, migration and invasion of SKOV3 cell lines and repressed tumor growth in xenografted ovarian models. 32779991 ELFN1-AS1 LncRNA Homo sapiens Osteosarcoma OS and in OS cells Interaction(miR-138-5p and miR-1291) qRT-PCR The level of ELFN1-AS1 was markedly upregulated in patients with advanced OS and in OS cells. Exosomal ELFN1-AS1 from 143B cells was able to promote macrophage M2 polarization, and M2 macrophage in return facilitated OS progression. Mechanistically, overexpression of ELFN1-AS1 upregulated CREB1 level via sponging miR-138-5p and miR-1291 in macrophage via. Yes In addition, overexpression of ELFN1-AS1 significantly promoted the proliferation, migration and invasion of OS cells, while knockdown of ELFN1-AS1 exhibited the opposite effects. 35785218 ELFN1-AS1 LncRNA Homo sapiens Esophageal Neoplasms ESCA tissues and cell lines regulation[GFPT1 ,miR-183-3p] qRT-PCR The lncRNA ELFN1-AS1 was significantly up-regulated in ESCA tissues and cell lines when compared with the counterparts. In summary, the results of this study suggest that the lncRNA ELFN1-AS1 facilitates the progression of ESCA by acting as a competing endogenous RNA (ceRNA) to promote GFPT1 expression via sponging miR-183-3p. Yes Down-regulation of ELFN1-AS1 restrained cell proliferation, migration, and invasion of ESCA in vitro. 32229685 ELFN1-AS1 LncRNA Homo sapiens Pancreatic Neoplasms The Cancer Genome Atlas (TCGA)-Pancreatic Adenocarcinoma (PAAD) data set Expression [highly expressed] In Vivo Experiment//Western Blot//Wound Healing Assay//Transfection//Flow Cytometry//CCK8//qRT-PCR//IF//IHC//Transwell Assay Through bio-information analysis and in vitro and in vivo experiments, we found that LncRNA ELFN1-AS1 was highly enriched in pancreatic cancer data sets and highly expressed in pancreatic cancer cell lines and tissues. Yes The knocking down of lncRNA ELFN1-AS1 significantly increased cancer cell death and growth arrest. Xenografts in nude mice showed that the growth of SW1990 cells in the mice group with a stable knock down of lncRNA ELFN1-AS1 was significantly slower than that in the control group. 34164511 ELFN1-AS1 LncRNA Homo sapiens Retinoblastoma retinoblastoma tissues and cell lines Interaction(miR-4270/SBK1 Axis) CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay ELFN1-AS1 was highly expressed in retinoblastoma tissues and cell lines. ELFN1-AS1 was the competing endogenous RNA for miR-4270 and promoted SBK1expression. ELFN1-AS1 was positively correlated with retinoblastoma progression and prognosis. Yes ELFN1-AS1 knockdown curtailed retinoblastoma proliferation, migration and invasion. 33574704 ELF3-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(hnRNPK) In Vivo Experiment//ChIP//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Transwell Assay We observed that ELF3-AS1 was highly expressed in GC tissues, and high ELF3-AS1 expression predicted poor prognosis. Mechanistic investigations revealed that ELF3-AS1 may regulate the downstream target gene, C-C motif chemokine 20, by binding with the RNA-binding protein hnRNPK. We observed that ELF3-AS1 was highly expressed in GC tissues, and high ELF3-AS1 expression predicted poor prognosis. T Yes The knockdown of ELF3-AS1 significantly inhibited cell proliferation, migration, and epithelial-mesenchymal transition and promoted apoptosis. 34418240 ELF3-AS1 LncRNA Homo sapiens Stomach Neoplasms GC cell and tissues Interaction(SNAI2-ELF3-AS1 feedback loop ) RNA Pull-Down//Western Blot//FISH//RIP//RNA-seq The ELF3 gene and antisense lncRNA ELF3-AS1 were both transcriptionally repressed by SNAI2 or SNAI1. Down-regulation of ELF3-AS1 and ELF3 predicted poor prognosis in GC. ELF3-AS1 mainly inhibited GC metastasis by repressing SNAI2 signaling. Additionally, ELF3-AS1 modulated ELF3 mRNA stability by RNA-RNA interaction. The RNA duplexes formed by ELF3 mRNA and lncRNA ELF3-AS1 directly interacted with the double-stranded RNA (dsRNA) binding protein complex ILF2/ILF3 (NF45/NF90). In turn, the ILF2/ILF3 complex dynamically regulated the expression of ELF3-AS1 and ELF3 by affecting the dsRNA stability. Down-regulation of ELF3-AS1 and ELF3 predicted poor prognosis in GC. Yes lncRNA ELF3-AS1 negatively regulated GC cell cycle progression via suppressing G1/S transition and histone synthesis. 36457025 ELF3-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[Downregulating miR-212] qRT-PCR//Colony Formation Assay//Transwell Assay In this study, the authors observed that ELF3-AS1 was upregulated in NSCLC tissues in comparison with that in paired nontumor tissues collected from 68 NSCLC patients.Therefore, ELF3-AS1 is upregulated in NSCLC and promotes cancer cell invasion and migration by downregulating miR-212 through methylation. Yes In addition, overexpression of ELF3-AS1 inhibited the role of miR-212 in suppressing cancer cell invasion and migration. 32598181 ELF3-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissue Regulation[ELF3-AS1/KLF8 signaling] RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Microarray ELF3-AS1 was highly expressed in bladder cancer and correlated with poor prognosis.Furthermore, ELF3-AS1 could interact with KLF8 to stabilize KLF8 by protecting it from proteasome-mediated degradation. KLF8 in turn could bind ELF3-AS1 promoter and transactivate ELF3-AS1 expression. The positive feedback loop between ELF3-AS1 and KLF8 enhanced KLF8 signaling by increasing MMP9 expression. Collectively, our study has unraveled a novel mechanism of ELF3-AS1-mediated oncogenesis in bladder cancer by reinforcement of ELF3-AS1/KLF8 signaling with potential implications for therapeutic intervention. Yes ELF3-AS1 could increase viability and migration of bladder cancer cells in vitro and promoted xenograft tumor growth in vivo. 30528231 ELF3-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues regulation[KLF12,miR-205 ] CCK8//qRT-PCR//Western Blot It was found that ELF3-AS1 was upregulated in OS tissues, and ELF3-AS1 expression level increased with increasing clinical stage. It was found that ELF3-AS1 was upregulated in OS tissues, and ELF3-AS1 expression level increased with increasing clinical stage. Yes ELF3-AS1 and KLF12 overexpression resulted in an increased proliferation rate in OS cells, while miR-205 played an opposite role and attenuated the effects of ELF3-AS1 overexpression. 32194747 ELF3-AS1 LncRNA Homo sapiens Glioma glioma specimens Expression[highly expressed] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The ELF3-AS1 expression level was significantly higher in glioma specimens compared with adjacent nontumor specimens (p < 0.01). A high expression of ELF3-AS1 was shown to be associated with the WHO grade (p = 0.023) and KPS score (p = 0.012). ROC assays revealed that high ELF3-AS1 expression had an AUC value of 0.8073 (95% CI: 0.7610 to 0.8535) for glioma. Using the Kaplan-Meier analysis, we found that patients with a high ELF3-AS1 expression had significantly poor OS (p = 0.006) and DFS (p = 0.0002). In a multivariate Cox model, we confirmed that ELF3-AS1 expression was an independent poor prognostic factor for glioma patients. Yes The functional assay revealed that knockdown of ELF3-AS1 suppressed the proliferation and invasion of glioma cells. 33014189 ELF209 LncRNA Homo sapiens Carcinoma, Hepatocellular Interaction[HNRNPAB] Western Blot//ISH//Migration Assay//qRT-PCR//FISH//RIP//Microarray//Invasion Assay//ChIP Furthermore, we found lnc-ELF209 could stabilize TPI protein expression. We also found that lnc-ELF209 overexpression in HCCLM3 cell resulted in a lower rate of lung metastatic, which suggested a less aggressive HCC phenotype. Collectively, these findings offer new insights into the regulatory mechanisms that underlie HNRNPAB cancer-promoting activities and demonstrate that lnc-ELF209 is a HNRNPAB-regulated lncRNA that may play an important role in the inhibition of HCC progression. Yes Up/downregulation assays and rescue assays indicate that lnc-ELF209 inhibits cell migration, invasion and epithelial-mesenchymal transition regulated by HNRNPAB. 31090062 ELDR LncRNA Homo sapiens Mouth Neoplasms OSCC samples and cell lines regulation[ILF3-cyclin E1 signaling] Flow Cytometry//qRT-PCR//RNA Pull-Down//FISH Here, we show that ELDR is highly expressed in OSCC patient samples and in cell lines. We further show that the ELDR-ILF3 axis regulates Cyclin E1 expression and phosphorylation of the retinoblastoma (RB) protein. Yes Overexpression of ELDR in normal non-tumorigenic oral keratinocytes induces cell proliferation, colony formation, and PCNA expression. We also show that ELDR depletion reduces OSCC cell proliferation and PCNA expression. 33043604 EIF4G3 CircRNA Homo sapiens Stomach Neoplasms GC tissues Interaction( miR-4449/SIK1 axis) Transfection//Co-IP//RIP//IP//IHC//IF Downregulated expression of circular RNA EIF4G3 (circEIF4G3; hsa_circ_0007991) was found in GC and was associated with poor clinical outcomes. Mechanistic studies revealed that circEIF4G3 bound to δ-catenin protein to promote its TRIM25-mediated ubiquitin degradation and interacted with miR-4449 to upregulate SIK1 expression. Downregulated expression of circular RNA EIF4G3 (circEIF4G3; hsa_circ_0007991) was found in GC and was associated with poor clinical outcomes. Yes Overexpression of circEIF4G3 suppressed GC growth and metastasis through the inhibition of β-catenin signaling, whereas knockdown of circEIF4G3 showed the opposite effects. 35780119 EIF3J-DT LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Regulation[miR-3163/YAP1 axis] Western Blot//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay Results showed that EIF3J-AS1 was upregulated in CRC tissues and cell lines. In conclusion, we first found that H3K27 acetylation-induced lncRNA EIF3J-AS1 improved proliferation and impeded apoptosis of colorectal cancer through the miR-3163/YAP1 axis, which might potentially provide a novel molecular-targeted strategy for CRC treatment. Yes The silence of EIF3J-AS1 led to reduced proliferation and facilitated apoptosis of CRC cells. 31709617 EIF3J-DT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[miR-122-5p/CTNND2 axis] qRT-PCR In the current study, we demonstrated that EIF3J-AS1 expression was obviously upregulated in HCC tissues compared to adjacent noncancerous tissues. Mechanistically, EIF3J-AS1 inversely regulated miR-122-5p expression via acting as a competing endogenous RNA (ceRNA) in HCC cells. Furthermore, catenin delta 2 (CTNND2) was recognized as a novel target of miR-122-5p. CTNND2 restoration partially reversed EIF3J-AS1 knockdown-induced inhibitory effects on HCC cell proliferation, migration and invasion. Importantly, we found that hypoxia induced EIF3J-AS1 and CTNND2 expression, and led to miR-122-5p downregulation in HCC cells. Notably, the expression of EIF3J-AS1 was correlated with prognostic features including tumor size, vascular invasion and tumor stage. Yes EIF3J-AS1 knockdown remarkably suppressed the proliferation, migration and invasion of HCC cells. 31421822 E2F4as LncRNA Homo sapiens Ovarian Neoplasms blood Expression[highly expressed] qRT-PCR Results: The expression of E2F4as was significantly higher in the serum of OC patients than in that of control patients (p < 0.05). Yes The knockdown of E2F4as in ovarian cancer cells led to a decrease in cell proliferation, invasion and migration and an increase in apoptosis. 33287341 E2F LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction[RUNX2] CCK8//qRT-PCR//IHC//Western Blot We found that lncRNA EPEL and Runt-related transcription factor 2 (RUNX2) were both Expression[Expression[up-expression]-expression]regulated in gastric cancer. EPEL and RUNX2 were positively correlated in tumor. Consistently, EPEL overexpression resulted in Expression[Expression[up-expression]-expression]regulated RUNX2 expression, while RUNX2 overexpression did not affect lncRNA EPEL expression. Patients with high expression level of lncRNA EPEL showed poor survival. Yes LncRNA EPEL and RUNX2 overexpression promoted, while lncRNA EPEL siRNA silencing inhibited the migration, proliferation, and invasion of gastric cancers. 31584135 DXL6-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Regulation[miR-223-HSP90B1 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Moreover, lncRNA DXL6-AS1 was upregulated in BC tissues and functioned as a sponge for miR-223 and reduced its expression in BC cells, thereby enhancing cell proliferation and invasion. Yes Moreover, lncRNA DXL6-AS1 was upregulated in BC tissues and functioned as a sponge for miR-223 and reduced its expression in BC cells, thereby enhancing cell proliferation and invasion. 31615303 DUXAP9 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue Interaction[ LINC01296/miR-598/Twist1 ] qRT-PCR "The results illustrated that the elevated LINC01296 expression in NSCLC tissue specimens and cell lines were closely correlated with the poor prognosis of patients with NSCLC.Mechanical studies showed that INC01296 harbored miR-598, acting as a microRNA ""sponge."" Besides, miR-598 targeted the 3'-UTR of Twist1. Interestingly, transcription factor Twist1 could bind with the promoter of INC01296 and activate its transcriptional level. In summary, we conclude that INC01296/miR-598/Twist1 constitutes a positive feedback loop to promote the tumorigenesis of NSCLC, providing a novel insight and a valuable therapeutic strategy." Yes Functional studies revealed that LINC01296 knockdown silenced by small interfering RNAs inhibited proliferation, accelerated apoptosis in vitro, and impaired tumor growth in vivo. 30240003 DUXAP8 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines interaction[EZH2 and H3K27me3] RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//EdU Staining//Transwell Assay The levels of lncRNA DUXAP8 were significantly increased in CRC tissues and CRC cell lines. Our data indicated that lncRNA DUXAP8 could induce the progression of CRC by negatively regulating E-cadherin via interaction with EZH2 and H3K27me3. Yes Knockdown of lncRNA DUXAP8 inhibited cell proliferation and the EMT process, and increased cell apoptosis, and overexpression of lncRNA DUXAP8 had an opposite effect. 33149618 DUXAP8 LncRNA Homo sapiens Colorectal Neoplasms human colorectal cancer tissues and cell lines Interaction(miR-519b/ZNF277 Axis) CCK8//qRT-PCR//Western Blot We found that the expression level of Duxap8 in colorectal cancer was closely correlated with tumor size (P = 0.024), tumor depth (P = 0.035) and lymphatic invasion (P =0.067) among 50 colorectal cancer patients. Then, we proved that the expression level of Duxap8 was significantly increased in human colorectal cancer tissues and cell lines. Mechanically, we found that Duxap8 was principally located in the cytoplasm. Furthermore, Duxap8 functioned as a competing endogenous RNA to induce the development and progression of colorectal cancer through sponging miR-519b-3p to upregulate ZNF277. We found that the expression level of Duxap8 in colorectal cancer was closely correlated with tumor size (P = 0.024), tumor depth (P = 0.035) and lymphatic invasion (P =0.067) among 50 colorectal cancer patients. Then, we proved that the expression level of Duxap8 was significantly increased in human colorectal cancer tissues and cell lines. Yes Functionally, Duxap8 knockdown inhibited the proliferation and induced the apoptosis of colorectal cancer cells, while Duxap8 overexpression facilitated the proliferation and suppressed the apoptosis in colorectal cancer in vitro. Moreover, knockdown of Duxap8 inhibited the size and weight of tumors in mice injected with colorectal cancer cells, overexpression of Duxap8 promoted the growth of colorectal cancer cells in vivo. 34511937 DUXAP8 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC cells Interaction(miR-223-3p/CXCR4 axis) CCK8//qRT-PCR//Wound Healing Assay We found that knockdown of DUXAP8 inhibited the proliferation, migration, and invasion of PTC cells. DUXAP8 could sponge miR-223-3p through the specific binding site. CXCR4 was a target of miR-223-3p. Yes We found that knockdown of DUXAP8 inhibited the proliferation, migration, and invasion of PTC cells. DUXAP8 could sponge miR-223-3p through the specific binding site. CXCR4 was a target of miR-223-3p.  33522355 DUXAP8 LncRNA Homo sapiens Thyroid Cancer, Papillary  tissues Interaction(miR‑20b‑5p/SOS1 axis) qRT-PCR//Luciferase Report Assay//RIP The analysis of the TCGA‑THCA data revealed that DUXAP8 was one of the most significantly upregulated lncRNAs in PTC. This finding was further confirmed in tissues from patients with PTC. The results of the present study also revealed that miR‑20b‑5p could directly target DUXAP8. Increased DUXAP8 expression was associated with higher grade and poorer prognosis in patients with PTC. Yes In PTC cell lines, silencing of DUXAP8 expression with small interfering RNA‑DUXAP8 (si‑DUXAP8) induced cell apoptosis and attenuated cell proliferation. Additionally, transfection of PTC cells with si‑DUXAP8 decreased the phosphorylation levels of MEK1/2 and ERK1/2, as well as downregulated the expression of son of sevenless 1 (SOS1), cyclin D1 (CCND1) and c‑Myc. 33760128 DUXAP8 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues interaction[Sponging MiR-490-5p] Flow Cytometry//qRT-PCR//Western Blot In this study, we found that lncRNA DUXAP8 was upregulated in tumor samples and served as an oncogene in HCC.Mechanically, the present study showed that DUXAP8 serves as a sponge of MiR-490-5p to promote the expression of BUB1 in HCC. Yes The knockdown of DUXAP8 significantly suppresses cell proliferation and the cell cycle but induces cell apoptosis in HCC. 32849765 DUXAP8 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC clinical samples regulation[miR-422a/PDK2 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay DUXAP8 expression HCC clinical samples was significantly increased and this was correlated with unfavorable pathological indexes.DUXAP8 was a sponge of tumor suppressor miR-422a in HCC, enhanced the expression of PDK2 indirectly, and functioned as an oncogenic lncRNA. High expression of DUXAP8 was associated with shorter overall survival time of patients. Yes Its overexpression remarkably facilitated the proliferation, metastasis, and epithelial-mesenchymal transition of HCC cells. Accordingly, knockdown of it suppressed the malignant phenotypes of HCC cells. 32022476 DUXAP8 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-9-3p/IGF1R axis) qRT-PCR//Luciferase Report Assay//RIP//Western Blot DUXAP8 and IGF1R were upregulated and miR-9-3p was downregulated in HCC tissues and cells compared with adjacent healthy tissues and a normal liver cell line, respectively. In addition, compared with the corresponding control groups, DUXAP8 knockdown and miR-9-3p overexpression suppressed proliferation, migration and invasion, which was reversed by miR-9-3p inhibitor and IGF1R overexpression, respectively. Yes In addition, compared with the corresponding control groups, DUXAP8 knockdown and miR-9-3p overexpression suppressed proliferation, migration and invasion, which was reversed by miR-9-3p inhibitor and IGF1R overexpression, respectively. 34035852 DUXAP8 LncRNA Homo sapiens Ovarian Neoplasms cells interaction[targeting miR-590-5p] qRT-PCR//Luciferase Report Assay//Western Blot Compared with normal ovarian cells, the expression of DUXAP8 in ovarian cancer cells was significantly increased, while the expression of miR-590-5p was decreased (p < 0.05).Taken together, lncRNA DUXAP8 can regulate the proliferation and apoptosis of ovarian cancer cells, and its mechanism may be related to the regulation of YAP1 gene by targeting miR-590-5p. Yes After DUXAP8 interference, cell proliferation and colony formation were decreased, and apoptosis was increased. The results of in vivo experiment are consistent with the in vitro experiments. 32749665 DUXAP8 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Regulation[PTEN] CCK8//qRT-PCR//Colony Formation Assay LncRNA DUXAP8 expression was higher in bladder cancer tissues; it was in a positive correlation with the TNM stage and tumor size, but negatively correlated with the total survival time.Our results pointed out that lncRNA DUXAP8 was overexpressed in bladder cancer tissues, which can promote the progression of bladder cancer through inhibiting PTEN. LncRNA DUXAP8 expression was higher in bladder cancer tissues; it was in a positive correlation with the TNM stage and tumor size, but negatively correlated with the total survival time. Yes Knockdown of DUXAP8 decreased cell viability and cellular proliferation. 29917188 DUXAP8 LncRNA Homo sapiens Osteosarcoma  OS samples and OS cell lines  Interaction(miR‑635/TOP2A axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The expression of lnc‑DUXAP8 was significantly upregulated in OS samples and OS cell lines compared with normal tissues. Yes Knockdown of lncRNA DUXAP8 inhibited proliferation, migration and invasion in OS cells. Notably, mechanistic investigation revealed that lncRNA DUXAP8 predominantly acted as a competing endogenous RNA in OS by regulating the miR‑635/topoisomerase alpha 2 (TOP2A) axis. 33982765 DUXAP8 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells Interaction( miR-1297/RCN2) In Vivo Experiment//RNA Pull-Down//Transfection//Tube Formation Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay DUXAP8 was notably upregulated in CC cells. Mechanically, DUXAP8 boosted the expression of reticulocalbin-2 (RCN2) through relieving the binding of miR-1297 to RCN2 3'-UTR. Moreover, miR-1297 inhibition and RCN2 overexpression could counteract the inhibitory effects of DUXAP8 knockdown on the malignant phenotypes of CC cells. Yes Downregulation of DUXAP8 repressed cell malignant behaviors and angiogenesis in CC. 34774078 DUXAP8 LncRNA Homo sapiens Glioma glioma tissues Expression[highly expressed] CCK8//qRT-PCR//Colony Formation Assay In the present study, it was revealed that pseudogene DUXAP8 is significantly upregulated in glioma tissues, compared with adjacent normal tissues. Patients with increased DUXAP8 expression were associated with higher Karnofsky Performance Status, advanced World Health Organization grade, poor disease-free survival and overall survival rates of patients with glioma. Yes Furthermore, in vitro assays, Cell-Counting Kit-8 cell viability and cell colony forming assays demonstrated that reduced DUXAP8 expression significantly suppressed proliferation capacity. 30867791 DUXAP8 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cells Interaction(miR-26b-5p) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay our results elucidated that that DUXAP8 promoted tumor progression in LUAD by targeting miR-26b-5p, which provide a novel therapeutic target for diagnosis and therapy of LUAD. Yes Loss-of-function experiments were performed to assess the function of DUXAP8 proliferation and apoptosis of H1975 and A549 cells. Functionally, silencing DUXAP8 inhibited proliferation and induced apoptosis of LUAD cells. 33269379 DUXAP8 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-409-3p/HK2/LDHA axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay DUXAP8 was highly expressed in NSCLC, while miR-409-3p was downregulated. DUXAP8 promoted cell viability, migration and glycolysis by regulating miR-409-3p/HK2/LDHA axis. High expression of DUXAP8 was positively related to the grade division and negatively associated with the 5-year survival rate of NSCLC patients. Yes Downregulated DUXAP8 significantly suppressed cell growth, metastasis and glycolysis. 32801745 DUXAP8 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[TRIM44-mediated AKT/mTOR pathway] qRT-PCR//MTT//RNA Pull-Down//Transwell Assay DUXAP8 and TRIM44 were upregulated in NSCLC tissues and cell lines, while miR-498 was downregulated.Our results identified that LncRNA DUXAP8 could regulate cell proliferation, metastasis and EMT in NSCLC cells by inhibiting miR-498 through the activation of TRIM44-mediated AKT/mTOR pathway. Yes Functionally, knockdown of DUXAP8 could repress proliferation, migration, invasion, Epithelial-Mesenchymal Transition (EMT) and phosphorylation of AKT/mTOR in NSCLC cells. 32271433 DUXAP8 LncRNA Homo sapiens Melanoma melanoma tissue and cells Interaction( miR-3182/NUPR1 pathway) RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay lncRNA DUXAP8 was upregulated in melanoma tissue and cells compared with normal tissues and cells. lncRNA DUXAP8 targeted miR-3182, while miR-3182 targeted NUPR1. The overexpression of NUPR1 reversed the effects of DUXAP8 knockdown or miR-3182 mimic on melanoma progression. The levels of DUXAP8 inversely correlated with survival time of patients with melanoma. Yes Knockdown of lncRNA DUXAP8 inhibited proliferation, migration and invasion of melanoma cells. 33981357 DUXAP8 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay DUXAP8 was overexpressed in ESCC tissues than that of normal adjacent tissues. DUXAP8 expression was positively correlated to tumor stage and lymph node metastasis, whereas negatively correlated to the survival rate of ESCC patients. Yes Cell proliferation, colony formation and invasion abilities were significantly decreased after knockdown of DUXAP8 in ESCC cells. 29771416 DUXAP8 LncRNA Homo sapiens Neuroblastoma NB tissues regulation[miR-29 ,NOL4L ] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay Collectively, DUXAP8 deteriorated NB through serving as a sponge for miR-29 to up-regulate the expression of NOL4L in vitro and in vivo. We found the expression of DUXAP8 was positively related to the stage of NB tumors, and it was negatively associated with the survival rate of NB patients. Yes DUXAP8 knockdown inhibited the proliferation, colony formation, cycle and motility of NB cells. 32522628 DUXAP8 LncRNA Homo sapiens Sinonasal Squamous Cell Carcinoma SNSCC cells Interaction(miR-584-5p/FNDC3B Pathway) RNA Pull-Down//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay DUXAP8 is overexpressed in SNSCC cells. Furthermore, DUXAP8 up-regulates the expression of FNDC3B via sponging miR-584-5p. Rescue experiments demonstrated that DUXAP8 mediates the progression of SNSCC via up-regulating FNDC3B expression. Yes Functionally, DUXAP8 silencing suppresses the malignant progression of SNSCC. 35695194 DUXAP8 LncRNA Homo sapiens Colorectal Neoplasms colorectal tissues Interaction[DUXAP8 ] CCK8//qRT-PCR//Luciferase Report Assay//ChIP In this study, we first provided evidence that DUXAP8 was overexpressed in CRC and increasing expression of DUXAP8 indicates advanced clinical progression and poor survival of CRC patients. Furthermore, an inverse relationship between DUXAP8 and miR-577 was found. In addition, we confirmed that DUXAP8 served as competing endogenous RNA to modulate miR-577, which can modulate RAB14, a well-studied oncogene. Yes Functional assays via in vitro assays revealed that DUXAP8 knockdown through shRNA in HCT116 and LOVO cells inhibited cell proliferation, migration and invasion, and promoted apoptosis. 31364111 DUXAP8 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[EZH2/LSD1] CCK8//qRT-PCR//RIP//EdU Staining//Transwell Assay LncRNA DUXAP8 was Expression[Expression[up-expression]-expression]regulated in CRC tissues and cell lines. Its level remained higher in CRC with larger tumor size or higher tumor grade.RIP assay further demonstrated the interaction between DUXAP8 and LSD1, EZH2. Yes KnockExpression[down-expression] of DUXAP8 sExpression[Expression[up-expression]-expression]pressed the proliferative, migratory and invasive abilities of DLD-1 and SW480 cells. 31786844 DUXAP8 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues and the normal tissue,cell lines(A549，SPC-A1，SK-MES-1,NCI-H1299) Expression[highly expressed] CCK8//qRT-PCR//Invasion Assay//Transwell Assay The expression of LncRNA DUXAP8 in tumor tissues was significantly higher than that of the normal tissue (P<0.001).Among 4 lung cancer cell lines, LncRNA DUXAP8 in A549 cells was the highest (P<0.001). Yes The results indicated that LncRNA DUXAP8 overexpression significantly promoted the A549 cells' proliferation, enhanced invasion and induced tumor growth. Conversely, LncRNA DUXAP8 knockout significantly suppressed A549 cells' proliferation, weakened invasion and inhibited tumor growth. 33817152 DUXAP9 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Regulation[miR-485-5p/PAK4 axis ] Western Blot//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay Our study showed that LINC01296 was over-expressed in OSCC tissues and cell lines. Knockdown of LINC01296 effectively inhibits cell viability, migration and invasion but promotes cell apoptosis in vitro. The in vivo experiment showed that LINC01296 knockdown inhibited OSCC tumor growth. The level of LINC01296 was positively correlated with the patient's tumor node metastasis (TNM) stage and nodal invasion. Yes Knockdown of LINC01296 effectively inhibits cell viability, migration and invasion but promotes cell apoptosis in vitro. The in vivo experiment showed that LINC01296 knockdown inhibited OSCC tumor growth. 35591837 DUXAP9 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[sponging miR-5095] CCK8//qRT-PCR//Wound Healing Assay//Luciferase Report Assay In our study, we indicate that the expression of LINC01296 was overexpressed in NSCLC samples compared to adjacent non-tumor tissues. Yes Ectopic expression of LINC01296 promoted NSCLC cell proliferation and migration. 30899389 DUXAP9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Regulation[KLF2] qRT-PCR//RIP//ChIP In the current study we showed that LINC01296 expression is significantly higher in ESCC tissues when compared with corresponding adjacent normal tissues.Moreover, RNA immunoprecipitation (RIP) and chromatin immunoprecipitation (ChIP) assays demonstrated that LINC01296 promotes cell proliferation and invasion by epigenetic suppression of KLF2 expression via an interaction with EZH2 in ESCC cells. Higher LINC01296 expression was associated with lymph node metastasis, TNM stage, and worse overall survival rate in ESCC patients. Yes Furthermore, functional assays in vitro demonstrated that knockdown of LINC01296 inhibited ESCC cell proliferation, colony formation, migration, and invasiveness. 30416853 DUXAP9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cell lines and cancerous tissues Expression[highly expressed] qRT-PCR//MTT//Transwell Assay We found that LINC01296 was upregulated in ESCC cell lines and cancerous tissues, as compared with normal esophagus cells and adjacent normal tissue samples. High LINC01296 expression was significantly correlated with differentiation grade (p=0.000), lymph nodes metastasis (p=0.002), distant metastasis (p=0.002), and TNM stage (p = 0.015). Moreover, ESCC patients with high LINC01296 expression experienced shorter OS and DFS (p=0.0009 and p=0.0005, respectively). Yes Functionally, the results of in vitro assay indicated that down-regulation of LINC01296 significantly suppressed ESCC cells proliferation, migration, and invasion, suggesting that LINC01296 contributed to tumorigenesis of ESCC. 30058683 DUXAP9 LncRNA Homo sapiens Carcinoma, Hepatocellular LCa tissues Regulation[regulating microRNA-760 ] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay LINC01296 expression was remarkably higher in LCa tissues than that of normal liver tissues. LINC01296 could promote the proliferative ability and invasiveness of hepatoma cells by inhibiting the expression of microRNA-760. Meanwhile, LINC01296 expression was associated with poor prognosis of LCa. Patients with high LINC01296 expression were more likely to have lymph node metastasis. Yes In vitro experiments showed that the knockdown of LINC01296 significantly inhibited the proliferation and migration of HCC cells. 31799652 DUXAP9 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue samples and cell lines regulation[miR-26a/PTEN axis] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Transwell Assay Linc01296 expression was increased in both HCC tissue samples and cell lines. These findings indicated that Linc01296 is involved in HCC progression via regulating miR-26a/PTEN. Yes Knockdown of Linc01296 suppressed HCC cell processes, such as proliferation, migration and invasion, and enhanced apoptosis in vitro; these effects were reversed by a miR-26a mimic or PTEN overexpression. 31318685 DUXAP9 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Interaction(3' untranslated region (UTR) of sox9) Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Invasion Assay We found that DUXAP9 positively regulated HCC cell stemness, as characterized by the change of sphere-formation ability, ALDH activity and stemness marker expression. Yes We found that DUXAP9 overexpression increased the expression of stemness markers(Nanog, Oct4, ABCG2) (Figure 1(B)–(D)), while DUXAP9 knockdown decreased it. 34086387 DUXAP9 LncRNA Homo sapiens Ovarian Neoplasms Interaction[regulating EMT] Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Cell Cycle Assay//Colony Formation Assay//Invasion Assay We found that LINC01296 was over-expressed in ovarian cancer tissues and cell lines, when comparing with adjacent normal tissue samples and normal cells. Moreover, western blotting analysis displayed that knockdown of LINC01296 significantly increased E-cadherin, but reduced N-cadherin and vimentin expressions in SKOV3 and OVCAR3 cells, compared with no-transfection cells. Higher LINC01296 expression was significantly correlated with shorter progression-free survival and overall survival. Yes For the functional experiments, knockdown of LINC01296 suppressed cell proliferation, inhibited colony formation ability, abrogated cell migration and invasion potential, and enhanced cell apoptosis. 31176022 DUXAP9 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[highly expressed] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Microarray//Colony Formation Assay//Transwell Assay The expression of LINC01296 was significantly higher in most cancer tissues than that in adjacent normal tissues, The expression of LINC01296 was significantly higher in most cancer tissues than that in adjacent normal tissues, and was positively correlated with clinical stages of the cancer (P=0.016), lymph node metastasis (P=0.034), and pathologic grades (P=0.012). The increased level of LINC01296 was associated with a poorer prognosis and shorter survival of the patients. Multivariate analysis showed that the LINC01296 expression was an independent predictor of overall survival in bladder cancer. Yes Additionally, LINC01296 knockdown inhibited the proliferation, migration and progression of cell cycle of bladder cancer cells, and was involved in the regulation of epithelial-mesenchymal transition. 30588032 DUXAP9 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck clinical samples and cell lines Interaction(SRSF1) qRT-PCR//FISH LINC01296 was highly expressed in clinical samples and cell lines of oral squamous cell carcinoma. In mechanism, LINC01296 plays a tumor-promoting role by binding to SRSF1 protein. Yes Overexpression of LINC01296 promoted the proliferation, invasion, and migration of oral squamous cell carcinoma cells and accelerated the formation of xenografts, while silencing LINC01296 inhibited tumor progression. 34195277 DUXAP9 LncRNA Homo sapiens Neoplasm Metastasis The matched lung cancer tissue (n=40) and the matched normal lung tissue, Paired colorectal cancer tissue (n=40) and matched normal bowel tissue (n=40) Interaction(miR-141-3p/ZEB1-ZEB2 axis) Transfection//Luciferase Report Assay//Western Blot In this study, we used non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) as the research objects, LINC01296 was found to be highly expressed in NSCLC and CRC tissues and positively related to poor prognosis. We also demonstrated LINC01296 regulated NSCLC and CRC invasion and metastasis by modulating epithelial-mesenchymal transition (EMT) by up-regulating ZEB1 and ZEB2. Consequently, LINC01296 acted as a sponge of miR-141-3p, which negatively regulates EMT process. In this study, we used non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) as the research objects, LINC01296 was found to be highly expressed in NSCLC and CRC tissues and positively related to poor prognosis. Yes We also demonstrated LINC01296 regulated NSCLC and CRC invasion and metastasis by modulating epithelial-mesenchymal transition (EMT) by up-regulating ZEB1 and ZEB2. Consequently, LINC01296 acted as a sponge of miR-141-3p, which negatively regulates EMT process. 33854632 DUXAP9 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell line Regulation(Wnt and MAPK signaling) qRT-PCR//Wound Healing Assay LINC01296 was overexpressed in the TCGA-OSCC datasets. LINC01296 was overexpressed in OSCC tissues compared with para-carcinoma tissues. Moreover, the expression of linc01296 was higher in CAL-27, HSC-2, and SCC-25 cells than in normal human oral keratinocytes (NHOKs). Functional analysis suggested that LINC01296might be involved in the regulation of the Wnt and MAPK signaling pathways. High LINC01296expression was strongly correlated with poor outcomes of OSCC patients. Yes Additionally, LINC01296 deficiency suppressed the growth, migration, and invasion of OSCC cells, whereas overexpression of TFAP2A-AS1 cause opposite results. 35154446 DUXAP9 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues Expression(highly expressed) qRT-PCR//Transwell Assay LINC01296 expression was notably up-regulated in HNSCC, which was associated with promoter hypomethylation. A Also, it was positively correlated with the HNSCC pathological stage and patients with higher LINC01296 expression levels had a poor prognosis. Yes LINC01296 silencing inhibits HNSCC cell migration and invasion. LINC01296 also participate in the HNSCC progression mainly through protein phosphorylation and microtubule-based process regulation. 34515611 DUXAP9 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissue,cell lines Interaction[Bcl-2/caspase-3 pathway] qRT-PCR LINC01296 was enhanced in PDAC tissues and cell lines. Moreover, silencing of LINC01296 followed by treatment with small interfering RNAs suppressed cell proliferation and promoted cell apoptosis by affecting the Bcl-2/caspase-3 pathway. Importantly, LINC01296 attenuation impaired the migratory and invasive potential partly by reversing EMT. LINC01296 was enhanced in PDAC tissues and cell lines, and this overexpression was correlated with advanced tumor stages and positive lymph node metastasis in patients with PDAC. In addition, upregulation of LINC01296 was an independent prognostic predictor for patients with PDAC after surgery. Yes Moreover, silencing of LINC01296 followed by treatment with small interfering RNAs suppressed cell proliferation and promoted cell apoptosis by affecting the Bcl-2/caspase-3 pathway. 30203487 DUXAP9 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells and patient tissues Interaction(miR-143-3p/ATG2B) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//Colony Formation Assay LINC01296 is the one with the most significant overexpression. LINC01296 also acts as the sponge of miR-143-3p. Lowering the expression of LINC01296 leads to decreased expression of autophagy-related 2B (ATG2B), a target gene of miR-143-3p. These results demonstrated that the LINC01296/miR-143-3p/ATG2B axis is crucial in promoting the development of NSCLC and paclitaxel resistance. Yes Knockdown of LINC01296 inhibits the growth and migration, arrests the cell cycle, and promotes the apoptosis of NSCLC cells. Knocking down LINC01296 in vivo suppresses tumor growth and metastasis. 34695177 DUXAP9 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cells Interaction(LINC01296/miR-5095/MYCN ) In Vivo Experiment//Western Blot//ISH//Transfection//Migration Assay//FISH//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Invasion Assay Microarray data analysis and reverse transcription-quantitative polymerase chain reaction analysis demonstrated that LINC01296 was significantly upregulated in human CCA compared with nontumor tissues.Mechanistically, LINC01296 was demonstrated to sponge microRNA-5095 (miR-5095), which targets MYCN proto-oncogene bHLH transcription factor (MYCN) mRNA in human CCA. By inhibition of miR-5095, LINC01296 overexpression upregulated the expression of MYCN and promoted cell viability, migration and invasion in CCA cells. Furthermore, the expression of LINC01296 in human CCA was positively associated with tumor severity and clinical stage. Yes Knockdown of LINC01296 dramatically suppressed the viability, migration and invasion of RBE and CCLP1 cells, and promoted cell apoptosis in vitro. Furthermore, LINC01296 knockdown inhibited tumor growth in a xenograft model. 29620172 DUXAP9 LncRNA Homo sapiens Kidney Neoplasms 112 pairs of localized ccRCC tumor tissues Regulation(IGF2BP2/PI3K/AKT ) RNA Pull-Down//Wound Healing Assay//Flow Cytometry//FISH//CCK8//Colony Formation Assay In this study, we characterized a lncRNA DUXAP9 and the upregulation of DUXAP9 was analyzed by quantitative real-time PCR in 112 pairs of localized ccRCC tumor tissues compared with adjacent normal tissues. Pull-down, RNA immunoprecipitation and RNA stability assays (involving actinomycin D) showed that DUXAP9 was methylated at N6-adenosine and binds to IGF2BP2, which increases its stability. DUXAP9 activate PI3K/AKT pathway and Snail expression in renal cancer cells. DUXAP9 expression was an independent risk factor for poor prognosis in localized ccRCC (p<0.05). Yes DUXAP9 knockdown in renal cancer cells inhibited renal cancer cells proliferation and motility capacities in vitro and reversed epithelial-mesenchymal transition (EMT), whereas overexpression of DUXAP9 promoted renal cancer cells proliferation and motility capacities in vitro and induced EMT. 34168980 DUXAP9 LncRNA Homo sapiens Neuroblastoma NB tissues and cell line Interaction( miR-584-5p, miR-34a-5p/TRIM59 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The level of LINC01296 and TRIM59 were increased, whereas miR-584-5p and miR-34a-5p levels were reduced in NB tissues in contrast to that in normal tissues. Moreover, miR-584-5p and miR-34a-5p were validated to act as a tumor repressive effect in NB cells by restraining TRIM59. The results also showed that LINC01296 could regulate the development of NB. In mechanism, LINC01296 acted as a miR-584-5p and miR-34a-5p sponge to modulate TRIM59 expression. In addition, LINC01296 knockdown also attenuated tumor growth in vivo. LINC01296 promotes the progression of NB by increasing TRIM59 expression via regulating miR-584-5p and miR-34a-5p, which also offered an underlying targeted therapy for NB treatment. Yes For functional analysis, LINC01296 deficiency inhibited the cell vitality, cell proliferation, migration and invasion in NB cells, whereas promoted cell apoptosis. 35305236 DLX6-AS1 LncRNA Homo sapiens Pre-Eclampsia PE placenta tissues regulation[ DLX6-AS1/miR-149-5p/ERP44] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Higher levels of DLX6-AS1 and ERP44, lower level of miR-149-5p were observed in PE placenta tissues.DLX6-AS1 inhibited proliferation and invasion of trophoblast cells, and suppressed angiogenesis of HUVEC cells by miR-149-5p/ERP44 pathway. Yes The inhibitory impact of DLX6-AS1 overexpression or ERP44 overexpression on proliferation and invasion of trophoblast cells as well as angiogenesis of HUVEC cells was reversed by up-regulating miR-149-5p. 32250737 DLX6-AS1 LncRNA Mus musculus Parkinson Disease PD mice Interaction(miR-223-3p/NRP1 axis) Flow Cytometry//qRT-PCR//MTT//Western Blot DLX6-AS1 was overexpressed in PD mice. DLX6-AS1 acted as the ceRNA of miR-223-3p to promote NRP1. Down-regulation of miR-223-3p or overexpression of NRP1 partially annulled the effect of silencing DLX6-AS1 on BV2 microglial inflammation. Overall, DLX6-AS1 promotes the microglial inflammatory response in PD through the ceRNA mechanism of miR-223-3p/NRP1. Yes Silencing DLX6-AS1 improved neurological function and alleviated microglial inflammation in PD mice. Silencing DLX6-AS1 inhibited LPS-induced inflammation of BV2 microglia. 35550840 DLX6-AS1 LncRNA Mus musculus Reperfusion Injury brain tissues regulation[miR-149-3p] qRT-PCR//Luciferase Report Assay//Tunel//Western Blot DLX6-AS1 levels were upregulated during ischemia/reperfusion (I/R) and downregulation of DLX6-AS1 reduced acute injury and ameliorated long-term neurological impairments induced by cerebral I/R in mice.Therefore, this suggests that miR-149-3p sponging by DLX6-AS1 may lead to cerebral neuron I/R-induced impairments through upregulation of apoptotic BOK activity, which offers a new approach to the treatment of stroke impairment. Yes Additionally, silencing of DLX6-AS1 significantly decreased the neuronal apoptosis in vivo and in vitro. 33216728 DCST1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[AKT/mTOR signaling pathways] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay LncRNA DCST1-AS1 was confirmed hyper-expression both in HCC tissues and HCC cells. Our results suggested that lncRNA DCST1-AS1, as a carcinogenic factor in HCC, promoted cell proliferation, and invasion, inhibited apoptosis and autophagy by modulating the AKT/mTOR signaling cascade. High expression of lncRNA DCST1-AS1 was significantly correlated with inferior prognosis. Yes Moreover, lncRNA DCST1-AS1 depletion suppressed proliferation and accelerated apoptosis, activated cycle arrest, restrained cell migration, and stimulated autophagy in HCC cells. 31364110 DCST1-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissue interaction[Sponge miR-92a-3p] qRT-PCR//Transwell Assay//Western Blot We in this study found that DCST1-AS1 was upregulated in EC. DCST1-AS1 is downregulated in EC and may sponge miR-92a-3p, thereby promoting cancer cell invasion and migration. Survival analysis revealed that high levels of DCST1-AS1 expression predicted poor survival of EC patients. Yes Moreover, DCST1-AS1 overexpression led to upregulated Notch1 and increased cancer cell invasion and migration rates. 32110096 DCST1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells regulation[miR-874-3p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay DCST1-AS1 expression was increased in cervical cancer tissues and cells. Inhibition of DCST1-AS1 suppressed the proliferation, migration and invasion of cervical cancer cells by increasing miR-874-3p expression, which could be alleviated by the inhibition of miR-874-3p. Yes Inhibition of DCST1-AS1 suppressed the proliferation, invasion and migration of cervical cancer cells and decreased the expression of KI67, proliferating cell nuclear antigen, matrix metalloproteinase (MMP)-2 and MMP-9. 33025624 DCST1-AS1 LncRNA Homo sapiens Glioblastoma GBM tissues regulation[miR-29b] qRT-PCR It was observed that the upregulation of DCST1-AS1 in GBM predicted poor survival. Yes Overexpression of DCST1-AS1 resulted in increased cell proliferation. 32418155 DCST1-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC patients Interaction(MiR-665/HOXB5 and MiR-873-5p/CADM1 Pathways) In Vivo Experiment//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Invasion Assay In this work, we identified a novel lncRNA DC-STAMP domain-containing 1-antisense 1 (DCST1-AS1), which is highly upregulated and correlated with poor survival in EC patients. Mechanistically, DCST1-AS1 mediated EC progression by inducing the expression of homeobox B5 (HOXB5) and cell adhesion molecule 1 (CADM1), via acting as a competing endogenous RNA for microRNA-665 (miR-665) and microRNA-873-5p (miR-873-5p), respectively. In addition, we found that the expression of miR-665 and miR-873-5p was significantly downregulated, while HOXB5 and CADM1 expression levels were increased in EC tissues. Yes Overexpression of DCST1-AS1 significantly enhanced EC cell proliferation, colony formation, migration, and invasion in vitro and promoted tumor growth of EC in vivo. 34497766 DCST1-AS1 LncRNA Homo sapiens cervical squamous cell carcinoma CSCC tissues regulation[ miR-107,CDK6 ] Western Blot//CCK8//qRT-PCR//MTT//Luciferase Report Assay We found that DCST1-AS1 was upregulated in CSCC and predicted poor survival.DCST1-AS1 may sponge miR-107 to upregulate CDK6 in CSCC. We found that DCST1-AS1 was upregulated in CSCC and predicted poor survival. Yes Moreover, overexpression of DCST1-AS1 led to upregulate CDK6 and increase cell proliferation rate, while overexpression of miR-107 played an opposite role and attenuate the effects of overexpression of DCST1-AS1. 32943926 DCAF1 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells Interaction(miR-93-5p/FRMD6 axis) colony Formation Assay//RNA Pull-Down//IHC//Western Blot//Transfection//qPCR//Colony Formation Assay//Flow Cytometry//RIP//MTT//PCR//IP//Transwell Assay//IF Circ_VPRBP was down-regulated in cervical cancer tissues and cells, and overexpression of circ_VPRBP inhibited proliferation and promoted apoptosis of Caski and C33A cells. MiR-93-5p was a target of circ_VPRBP, and miR-93-5p mimic reversed the effect of circ_VPRBP on cell behavior. FRMD6 was a downstream target of miR-93-5p, and down-regulated FRMD6 reversed the cell viability, migration and invasion of cervical cancer cells inhibited by anti-miR-93-5p. Circ_VPRBP inhibited tumor growth by regulating miR-93-5p and FRMD6 in vivo. Yes Circ_VPRBP was down-regulated in cervical cancer tissues and cells, and overexpression of circ_VPRBP inhibited proliferation and promoted apoptosis of Caski and C33A cells. 35501594 DBH-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Regulation[miR-138/FAK/Src/ERK pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay DBH-AS1 expression was upregulated and miR-138 expression was downregulated in HCC tissues and cells. DBH-AS1 facilitated the development of HCC via miR-138/FAK/Src/ERK pathway, establishing the molecular basis of DBH-AS1 in clinical application for HCC. Yes DBH-AS1 silencing and miR-138 overexpression reduced cell viability, inhibited colony formation, and induced apoptosis. 30142544 DBH-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissue and cell lines Regulation[PI3K-AKT signaling pathways] CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//EdU Staining We observed that DBH-AS1 was distinctly overexpressed in osteosarcoma tissue and cells, and associated with lymph node status and metastasis status.Moreover, suppression of DBH-AS1 could inhibit the activation of the PI3K/Akt pathway, which was demonstrated by examining the expression levels of p-PI3K and p-Akt. Osteosarcoma patients with a higher DBH-AS1 expression showed significantly poorer overall survival than those with lower DBH-AS1 expression. Yes Functional assays revealed that knockdown of DBH-AS1 inhibited cell proliferation, migration and invasion, while promoted apoptosis in osteosarcoma. 30840262 DBH-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells Interaction(miR-3163/USP44 axis) In Vivo Experiment//MeRIP//qPCR//Luciferase Report Assay//Colony Formation Assay We found that PC tissues exhibited DBH-AS1 downregulation that was particularly pronounced in gemcitabine-resistant PC tissues and cells. Mechanistically, DBH-AS1 was able to increase PC cell sensitivity to gemcitabine by sequestering miR-3163 and thus upregulating USP44 in these tumor cells. Clinically, patient-derived PC tumor xenografts exhibiting high levels of DBH-AS1 expression were found to be responsive to gemcitabine treatment. This DBH-AS1 downregulation was negatively correlated with the malignancy of PC tumors and with patient survival outcomes. Yes Additionally, decreased DBH-AS1 expression in PC was found to be linked to the METTL3-dependent m6A methylation of the lncRNA, with functional analyses revealing that DBH-AS1 was able to suppress the growth of PC cells. 35433957 DBH-AS1 LncRNA Homo sapiens Melanoma melanoma tumor tissues and cell lines regulation[miR-223-3p/EGFR/AKT axis] colony Formation Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Herein, we observed significant reductions in DBH-AS1 expression in melanoma tumor tissues and cell lines. These findings therefore suggest that DBH-AS1 can enhance glycolytic activity in melanoma cells, thereby disrupting melanoma progression via miR-223-3p/EGFR/AKT axis. Yes Knockdown DBH-AS1 in melanoma cells impaired their proliferative, migratory, and invasive potential. 32744696 DBH-AS1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBC tissues and cells regulation[DBH-AS1/BUD13/FN1 axis] qRT-PCR In this research, long non-coding RNA dopamine β hydroxylase antisense RNA 1 (DBH-AS1) was found to be upregulated in DLBC tissues and cells. In this way, DBH-AS1/BUD13/FN1 axis was confirmed. Yes Knockdown of DBH-AS1 suppressed the proliferation, migration, and invasion of cancer cells. 32091157 DATOC-1 LncRNA Mus musculus Carcinoma, Ovarian Epithelial EOC tissues Interaction( miR7) qRT-PCR We identified the lncRNA RP5-1120P11.1 as DATOC-1, which highly expressed in EOC tissues than in adjacent. Furthermore, knockdown of DATOC-1 increased the expression of miR7. The evidence showed that miR7 functioning as a tumor suppressor gene in EOC. And Kaplan-Meier analysis indicated that the patients with EOC that expressed high levels of DATOC-1 had a worse prognosis and shorter disease OS compared with DATOC-1 low-expressed patients. Yes In addition, DATOC-1 were further identified participating in EOC cell proliferation, cell cycle regulation and cell invasion. And knockdown of DATOC-1 inhibits tumor progression in vivo. 35116553 DARS1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-3200-5p/CKAP2 and FAK-ERK pathway) qRT-PCR DARS-AS1 was overexpressed in HCC tissues (vs. that in non-tumor tissues) and was closely correlated with the patients' tumor stage. DARS-AS1 up-regulated CKAP2, which aggravated HCC. Further investigation illustrated that either DARS-AS1 or CKAP2 activated FAK-ERK pathway, and miR-3200-5p was competitively restrained by DARS-AS1. miR-3200-5p exerted tumor-suppressive effects in HCC and inactivated CKAP2 and FAK-ERK pathway. DARS-AS1 was overexpressed in HCC tissues (vs. that in non-tumor tissues) and was closely correlated with the patients' tumor stage. Yes DARS-AS1 facilitated HCC cell proliferation and hampered apoptosis. HCC cell migration and EMT were enhanced by DARS-AS1. 34596006 DARS1-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC cell model Interaction(miR-194-5p/TSPAN1 and ITGA2 ) qRT-PCR//ChIP//Western Blot The OC cell model exhibited overexpressed lncRNA DARS-AS1 compared to normal cells. lncRNA DARS-AS1 positively regulated TSPAN1 expression by binding with miR-194-5p and TSPAN1-mediated ITGA2 hypomethylation in OC cells. Further rescue function studies demonstrated that lncRNA DARS-AS1 affected OC cell viability, migration, invasion, and apoptosis ability by modulating miR-194-5p and TSPAN1 expressions. Yes lncRNA DARS-AS1 knockdown led to reduced OC cell growth and metastasis while inducing the apoptosis in the OC cell model. 36187230 DARS1-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma specimens, osteosarcoma cell lines (Saos-2, SOSP-9607, U2OS, and MG-63) Interaction(miR-532-3p/CCR7) qRT-PCR//Luciferase Report Assay We firstly showed that DARS-AS1 expression is upregulated in 73.5% (25/34) of cases with osteosarcoma. Moreover, DARS-AS1 expression is overexpressed in osteosarcoma specimens than in nontumor samples. The DARS-AS1 is overexpressed in the osteosarcoma cell lines (Saos-2, SOSP-9607, U2OS, and MG-63) compared to hFOB. These data firstly suggested that DARS-AS1 exerted as one oncogene in osteosarcoma partly via regulating miR-532-3p/CCR7. Yes Overexpression of DARS-AS1 promotes cell growth and invasion in MG-63 osteosarcoma cell. 35422889 DARS1-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow tissues interaction[Binding to microRNA-425] qRT-PCR//Western Blot DARS-AS1 was overexpressed in bone marrow tissues of AML patients and cells, and DARS-AS1 knockdown suppressed the proliferation of AML cells and induced apoptosis.All in all, we highlighted here that DARS-AS1 enhanced the expression of TGFB1 through binding to miR-425 to modulate AML progression via the Smad2/3 pathway, which might perform as a therapeutic target for AML. Yes DARS-AS1 was overexpressed in bone marrow tissues of AML patients and cells, and DARS-AS1 knockdown suppressed the proliferation of AML cells and induced apoptosis. 33073700 DARS1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines regulation[Downregulating HMGB1 via Sponging miR-188-5p] Flow Cytometry//qRT-PCR//IF//Luciferase Report Assay//Transwell Assay Downregulation of DARS-AS1 markedly inhibited the proliferation and invasion of cervical cancer cells.In this study, we found that DARS-AS1 knockdown suppressed the growth of cervical cancer cells via downregulating HMGB1 via sponging miR-188-5p. Yes Downregulation of DARS-AS1 markedly inhibited the proliferation and invasion of cervical cancer cells. Moreover, DARS-AS1 knockdown obviously induced the apoptosis of SiHa and HeLa cells. 33176595 DARS1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cells Regulation(IGF2BP3) In Vivo Experiment//RNA Pull-Down//Western Blot//Transwell Assay//Transfection//CCK8//qRT-PCR//FISH//Flow Cytometry//Colony Formation Assay//Invasion Assay//IF Downregulation of DARS-AS1 significantly induced apoptosis and cell cycle arrest in cervical cancer cells. Meanwhile, the invasion ability of cervical cancer cells was inhibited by DARS-AS1 knockdown as well. RNA pull-down and FISH results showed that DARS-AS1 interacted with IGF2BP3. Mechanistically, DARS-AS1 positively regulated IGF2BP3 expression via stabilization of IGF2BP3 mRNA. Yes Downregulation of DARS-AS1 significantly induced apoptosis and cell cycle arrest in cervical cancer cells. Meanwhile, the invasion ability of cervical cancer cells was inhibited by DARS-AS1 knockdown as well. In addition, in vivo experiments revealed that downregulation of DARS-AS1 inhibited tumor growth in SiHa xenograft model. 33658798 DCST1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cell Regulation(NF-κB signaling) CCK8//qRT-PCR//IHC//Western Blot Here, we reported that DCST1-AS1 was significantly increased in OSCC cells. Then, we observed that loss of DCST1-AS1 suppressed OSCC progression via inactivating NF-κB signaling. As well established, NF-κB signaling exerts critical roles in tumor progression, and our study proved that DCST1-AS1 could regulate NF-κB signaling. Yes We found that loss of DCST1-AS1 obviously inhibited the proliferation, migration, and invasion of OSCC cells and xenograft tumor growth. Meanwhile, silencing of DCST1-AS1 also repressed the percentage of macrophages expressing M2 markers CD206 and CD11b. DCST1-AS1 shRNA enhanced the percentage of macrophages expressing M1 markers CD80 and CD11c. T 34414241 DCST1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[sponging miR-1254] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay LncRNA DCST1-AS1 was highly expressed in HCC tissues.DCST1-AS1 up-regulates the expression of FAIM2 by up-regulating the expression of miR-1254, ultimately promoting the proliferation of HCC cells. Dual‑luciferase reporter assays demonstrated that SPRY4‑IT1 may have regulated the expression of ZEB1 and ZEB2 by sponging miR‑101. In conclusion, SPRY4‑IT1 inhibition increased miR‑101 levels, resulting in downregulation of ZEB1/2 expression and thus exerting anti‑tumour effects in OS. LncRNA DCST1-AS1 was highly expressed in HCC tissues, and the high expression of DCST1-AS1 was significantly correlated with larger tumours and shorter survival time. Yes Moreover, DCST1-AS1 knockout significantly inhibited proliferation, promoted apoptosis and cycle arrest of HCC cells, and inhibited tumour growth in vivo 30617187 DGCR5 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Interaction(miR-211-5p/Snail Signal Axis) Western Blot//qPCR//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//EdU Staining//Transwell Assay Quantitative polymerase chain reaction further demonstrated that the expression level of DGCR5 major isoform (isoform-1) was higher in ccRCC tissues than that in papillary/chromophobe RCC and other multiple solid malignant tumors. Thus, our study indicates that DGCR5 isoform-1 could contribute to ccRCC progression by sponging miR-211-5p through regulating the expression of Snail protein and could serve as a reliable diagnostic biomarker in ccRCC. Yes Thus, our study indicates that DGCR5 isoform-1 could contribute to ccRCC progression by sponging miR-211-5p through regulating the expression of Snail protein and could serve as a reliable diagnostic biomarker in ccRCC. 34322486 DCST1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(hsa-miR-582-5p/HMGB1 axis ) RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//cell invasion assay//Colony Formation Assay We found that the expression of lncRNA DCST1-AS1 was up-regulated in CRC tissues and cell lines, and CRC patients with high lncRNA DCST1-AS1 expression were associated with a poor prognosis. Functional assay further confirmed the crucial role of lncRNA DCST1-AS1/hsa-miR-582-5p/HMGB1 axis in modulating the malignant phenotype of CRC cells. We found that the expression of lncRNA DCST1-AS1 was up-regulated in CRC tissues and cell lines, and CRC patients with high lncRNA DCST1-AS1 expression were associated with a poor prognosis. Yes . Loss-of-function and gain-of-function experiment in CRC cell lines confirmed that lncRNA DCST1-AS1 promoted the malignant phenotype of CRC cells, including cell proliferation, colony formation, migration, and invasion. 34967274 DEPDC1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(F11R) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//IF//Colony Formation Assay//Transwell Assay DEPDC1-AS1 was overexpressed in GC tissues and cell lines, and associated with a worse prognosis in GC patients. Mechanistically, DEPDC1-AS1 served as a scaffold by combining with HuR to target the specific mRNA F11R. DEPDC1-AS1 was overexpressed in GC tissues and cell lines, and associated with a worse prognosis in GC patients. Yes In vitro and in vivo assays showed that DEPDC1-AS1 promoted HGC-27 cell proliferation and migration. 35466755 DENND1B CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC cells Interaction(miR-122-5p/TIMP2 axis) colony Formation Assay//Western Blot//Transfection//Colony Formation Assay//Flow Cytometry//qRT-PCR//IF//MTT//PCR//IP//IHC//Transwell Assay circ_DENND1B was downregulated in ccRCC and circ_DENND1B overexpression suppressed the malignant behaviors of ccRCC cells. circ_DENND1B acted as a sponge of miR-122-5p. miR-122-5p upregulation reversed the effects of circ_DENND1B on cell proliferation, migration, invasion and apoptosis.TIMP2 was a target of miR-122-5p. Overexpression of circ_DENND1B regulated TIMP2 level by inhibiting miR-122-5p expression in ccRCC cells. Yes circ_DENND1B acted as a sponge of miR-122-5p. miR-122-5p upregulation reversed the effects of circ_DENND1B on cell proliferation, migration, invasion and apoptosis. circ_DENND1B overexpression inhibited the tumor growth of ccRCC in vivo. 36578555 DDX3ILA1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[DDX3/YY1/MMP1/PI3K-AKT axis ] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//RIP//Colony Formation Assay//EdU Staining//Transwell Assay Elevated expression of TCONS_00012883 was confirmed in CRC and positively associated with a poor prognosis. TCONS_00012883 significantly promoted CRC progression via the DDX3/YY1/MMP1 axis, and thus, may act as a major role in diagnosis and therapy of CRC. Elevated expression of TCONS_00012883 was confirmed in CRC and positively associated with a poor prognosis. Yes Functionally, gain- and loss-of-function assays indicated that TCONS_00012883 promoted proliferation and metastasis of CRC cell lines in vitro and in vivo. 33135346 DDX21 LncRNA Homo sapiens Breast Neoplasms BC cell lines Interaction(miR‐1264/QKI axis) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Wound Healing Assay//qRT-PCR//FISH//IF//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircDDX21 expression was downregulated in the normal mammary gland cell line MCF10A compared with other BC cell lines Interestingly, low expression of circDDX21 indicated prolonged survival in TNBC patients Yes Overexpression of circDDX21 repressed the proliferation, migration, invasion and clone formation abilities of the two TNBC cell lines, whereas circDDX21 knockdown promoted these abilities 35522944 DDX11‑AS1 LncRNA Homo sapiens Breast Neoplasms MCF‑7 and MDA‑MB‑231 cells Regulation(microRNA‑497) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//IF//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The present study demonstrated that the expression levels of lncRNA DDX11‑AS1 were markedly increased in paclitaxel (PTX)‑resistant breast cancer cell lines. By contrast, knockdown of DDX11‑AS1 expression inhibited PTX resistance of breast cancer cells, and suppressed the proliferation, invasion and migration of breast cancer cells, which was achieved via upregulation of miR‑497 expression. In conclusion, knockdown of lncRNA DDX11‑AS1 could inhibit the proliferation, migration and PTX resistance of breast cancer cells by upregulating miR‑497 expression. Yes By contrast, knockdown of DDX11‑AS1 expression inhibited PTX resistance of breast cancer cells, and suppressed the proliferation, invasion and migration of breast cancer cells, which was achieved via upregulation of miR‑497 expression. 35169864 DDX11-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tumour tissues and cells regulation[miR-873-5p/SPC18 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining In this study, we found that DDX11-AS1 expression was up-regulated in GC tumour tissues and cells. In conclusion, DDX11-AS1 may serve as an oncogene in GC progression by sponging miR-873-5p and promoting SPC18 expression, providing a new insight into the mechanisms of DDX11-AS1 and elucidating a promising therapy target in GC. Increased DDX11-AS1 expression was associated with advanced TNM stage and lymph node metastasis. Yes Functionally, knockdown of DDX11-AS1 repressed cell proliferation and clone formation, while induced cell cycle arrest and apoptosis. 32054332 DDX11-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumour tissues and cells regulation[PI3K/AKT signalling] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay The level of lncRNA DDX11-AS1 was up-regulated in NSCLC tumour tissues and cells. All in all, DDX11-AS1 promotes NSCLC development via regulating PI3K/AKT signalling. Yes In function aspect, knockdown of DDX11-AS1 caused an apparent inhibitive effect on cell proliferation in vitro and in vivo. DDX11-AS1 inhibition promoted cell apoptosis in vitro. 32298476 DDX11-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation[miR-873/CLDN7 axis] qRT-PCR//ChIP We identified DDX11-AS1 as a new CRC-related lncRNA whose levels were distinctly up-regulated in CRC specimens and cell lines, partly induced by YY1. Mechanistic studies showed that the up-regulation of DDX11-AS1 competitively bound to miR-873 prevented CLDN7 from miRNAs-mediated degradations, thus facilitated the CRC progress. Further rescue assays were carried out to achieve confirmation. Clinical explorations suggested that increased expressions of DDX11-AS1 in CRC were positively associated with lymph nodes metastasis and TNM stage and had a distinct influence on the overall survival. Further multivariate assays indicated that DDX11-AS1 was an independent prognostic parameter implying a poorer clinical outcome for patients with CRC. Yes Functional assays revealed that the knockdown of DDX11-AS1 suppressed the proliferation, migration, and invasion of CRC cells, and stimulate apoptosis. 31298324 DDX11-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[ miR-195-5p/MACC1 pathway] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay DDX11-AS1 was upregulated in HCC tissues and cells,In addition, MACC1 was a target of miR-195-5p, and its overexpression reversed the suppression effect of miR-195-5p on HCC cell progression. Yes DDX11-AS1 was upregulated in HCC tissues and cells, and its silencing could inhibit HCC cell proliferation, migration, invasion and glucose metabolism, and promote apoptosis in vitro. Also, DDX11-AS1 knockdown reduced HCC tumor growth in vivo. 32961346 DDX11-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell line Interaction(miR-34a-3p/TRAF5 ) qRT-PCR Elevated DDX11-AS1 and TRAF5 and reduced miR-34a-3p exhibited in HCC. In addition, DDX11-AS1 bound to miR-34a-3p to target TRAF5. Silencing TRAF5 or elevating miR-34a-3p expression mitigated up-regulated DDX11-AS1-mediated promotion of tumor growth. Yes Silenced DDX11-AS1 or up-regulated miR-34a-3p inhibited the proliferation, migration, invasion, promoted apoptosis of HCC cells and repressed the tumor growth in nude mice. 33752668 DDX11-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma cells regulation[DDX11] RNA Pull-Down//IHC//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In this research, a dramatically upregulated expression of DDX11-AS1 was detected in osteosarcoma cells.To sum up, DDX11-AS1 contributes to osteosarcoma progression via stabilizing DDX11. Yes Loss-of-function assays revealed that decreased expression of DDX11-AS1 impaired osteosarcoma cell proliferation, metastasis as well as epithelial-mesenchymal transition (EMT) process. 32014424 DDX11-AS1 LncRNA Homo sapiens Glioma glioma tissues Interaction(HNRNPC axis) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Cell Apoptosis Assay//IHC//Bioinformatics Analysis In this study, we found that the expression of DDX11-AS1 was elevated in glioma tissues, and patients with high expression of DDX11-AS1 had poor prognosis.Mechanistically, DDX11-AS1 interacted with RNA-binding protein heterogeneous nuclear ribonucleoprotein C (HNRNPC) to promote Wnt/β-catenin and AKT pathways and the epithelial-mesenchymal transition process. In this study, we found that the expression of DDX11-AS1 was elevated in glioma tissues, and patients with high expression of DDX11-AS1 had poor prognosis.DDX11-AS1 was a potential prognostic marker. Yes Functionally, DDX11-AS1 promoted glioma cell proliferation and migration. 35614994 DDX11-AS1 LncRNA Homo sapiens esophageal carcinoma ESCA tissues and cell lines Interaction(miR-514b-3p/RBX1 axis) Bioinformatics Analysis We found that the expression of lncRNA DDX11-AS1 in ESCA tissues and cell lines was significantly upregulated. In terms of mechanism, our data showed that miR-514b-3p/RING box protein 1 (RBX1) axis played a crucial role in the oncogenic function of lncRNA DDX11-AS1. LncRNA DDX11-AS1 expression impaired the inhibitory function of miR-514b-3p on RBX1 through sponging effect. Yes Subsequently, silencing lncRNA DDX11-AS1 significantly inhibited the proliferation, migration and invasion of ESCA cells, and induced the level of cell apoptosis. 34281459 DDX11-AS1 LncRNA Homo sapiens Liver Neoplasms HCC tissues and cells Interaction(PARP1/p53 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Co-IP//Migration Assay//qRT-PCR//FISH//RIP//RNA-seq//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//IHC Upregulation of DDX11-AS1 expression through demethylation was significantly associated with a poor prognosis. Further mechanistic studies revealed that DDX11-AS1 promoted the growth of HCC by interacting with PARP1 through attenuating its binding to p53, leading to downregulated expression of p53 for inhibiting the transcription of downstream genes such as p21. Upregulation of DDX11-AS1 expression through demethylation was significantly associated with a poor prognosis Yes Knockdown of DDX11-AS1 expression in xenograft mice using anti-DDX11-AS1 oligonucleotide suppressed liver tumor proliferation. These findings indicate that DDX11-AS1 plays a role in the development of liver cancer by affecting the cell cycle. 34371129 DDX11 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Interaction(miR-30d-5p/SNAI1/ZEB2 ) qRT-PCR//Bioinformatics Analysis//RIP In this research, high DDX11-AS1 expression was detected in ESCC cells as well as tissues and was linked to the poor prognosis of patients with ESCC. Mechanistic analysis depicted that DDX11-AS1 may function as a ceRNA through sponging miR-30d-5p to upregulate the expression of SNAI1 and ZEB2. Meanwhile, overexpression of DDX11-AS1 might cause the activation of the Wnt/β-catenin signaling pathway via targeting miR-30d-5p. In this research, high DDX11-AS1 expression was detected in ESCC cells as well as tissues and was linked to the poor prognosis of patients with ESCC. Yes DDX11-AS1 promoted cell proliferation, migration, invasion ability and epithelial mesenchymal transition (EMT) process in vitro. 34866524 DDN-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Interaction[DDN-AS1-miR-15a/16-TCF3 ] qRT-PCR On the basis of the data of The Cancer Genome Atlas, lncRNA DDN and PRKAG1 antisense RNA 1 ( DDN-AS1) that is overexpressed in CC tissues predicted poor prognosis for patients with CC. Moreover, quantitative reverse transcription PCR analysis further identified the upregulation of DDN-AS1 in CC tissues and cell lines.Mechanism investigations revealed that DDN-AS1 was upregulated by its upstream transcription activator transcription factor 3 ( TCF3). Moreover, DDN-AS1 increased the expression of TCF3 by competitively binding miR-15a and miR-16. In conclusion, DDN-AS1-miR-15a/16-TCF3 feedback loop contributes to cell proliferation, migration, and invasion in CC. Yes Loss-of-function assays revealed that knockdown of DDN-AS1 suppressed CC progression by efficiently inhibiting cell proliferation, migration, and invasion. 30582201 DDGC LncRNA Homo sapiens primary ovarian insufficiency GCs from patients with biochemical premature ovarian insufficiency Interaction(RAD51 and WT1) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Co-IP//CCK8//qRT-PCR//FISH//RIP//RNA-seq//Luciferase Report Assay//Cell Cycle Assay//EdU Staining//IF Here, we recognized a minimally expressed lncRNA RP4-545C24.1 (which we named DDGC) in GCs from patients with biochemical premature ovarian insufficiency (bPOI). Mechanistically, silencing DDGC downregulated RAD51 by competitively binding with miR-589-5p, and this resulted in significant inhibition of DNA damage repair capacity.In addition, decreased expression of DDGC promoted ubiquitin-mediated degradation of Wilms tumor 1 (WT1) protein through interactions with heat shock protein 90 (HSP90), which led to aberrant differentiation of GCs. Yes Mechanistically, silencing DDGC downregulated RAD51 by competitively binding with miR-589-5p, and this resulted in significant inhibition of DNA damage repair capacity. In addition, decreased expression of DDGC promoted ubiquitin-mediated degradation of Wilms tumor 1 (WT1) protein through interactions with heat shock protein 90 (HSP90), which led to aberrant differentiation of GCs. Moreover, DDGC was able to ameliorate the etoposide-induced DNA damage and apoptosis in vivo. 34786213 DCST1-AS1 LncRNA Homo sapiens Breast Neoplasms TNBC tissue samples and cell lines interaction[miR-873-5p,MYC] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Colony Formation Assay//Transwell Assay Consistent with the microarray results, we found that DCST1-AS1 was up-regulated in both TNBC tissue samples and cell lines.MYC, DCST1-AS1 and miR-873-5p form a positive regulatory loop to promote TNBC cell proliferation and metastasis. Yes Knockdown of DCST1-AS1 inhibits TNBC cell proliferation and metastasis, while overexpression of DCST1-AS1 promotes TNBC cell proliferation and metastasis. 31897227 DARS1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction(ATP1B2/cGMP-PKG pathway) Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Invasion Assay//Transwell Assay DARS-AS1 was expressed at high levels in CC tissues and cell lines, and high expression of DARS-AS1 indicated a lower survival rate.Then, biological function experiments exhibited that the promotion of cell proliferation, invasion, and migration resulted due to the upregulation of DARS-AS1 could be canceled by ATP1B2 overexpression. Finally, Western blot revealed that upregulation of DARS-AS1 could activate the cGMP-PKG pathway, while overexpression of ATP1B2 reversed this activation. DARS-AS1 was expressed at high levels in CC tissues and cell lines, and high expression of DARS-AS1 indicated a lower survival rate. Yes Then, biological function experiments exhibited that the promotion of cell proliferation, invasion, and migration resulted due to the upregulation of DARS-AS1 could be canceled by ATP1B2 overexpression. Finally, Western blot revealed that upregulation of DARS-AS1 could activate the cGMP-PKG pathway, while overexpression of ATP1B2 reversed this activation. 33634536 DARS1-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC clinical tumors and cells Interaction(miR-129-2-3p/CDK1/ NF-κB/STAT3 signaling pathway) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Tunel//qRT-PCR//Luciferase Report Assay//H&E Staining//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay In this study, DARS-AS1, a newly reported CUMS-responsive lncRNA, was found to be enriched in TNBC clinical tumors and cells and positively correlated with late clinical stage in patients with TNBC. DARS-AS1 overexpression significantly enhanced the migration and invasion of TNBC tumors by inhibiting miR-129-2-3p and upregulated CDK1 to activate the NF-κB/STAT3 signaling pathway both in vitro and in vivo. In this study, DARS-AS1, a newly reported CUMS-responsive lncRNA, was found to be enriched in TNBC clinical tumors and cells and positively correlated with late clinical stage in patients with TNBC. Yes DARS-AS1 overexpression significantly enhanced the migration and invasion of TNBC tumors by inhibiting miR-129-2-3p and upregulated CDK1 to activate the NF-κB/STAT3 signaling pathway both in vitro and in vivo. 35688263 DARS1-AS1 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues Interaction[microRNA-129] CCK8//qPCR//Transwell Assay qPCR results revealed that the level of DARS-AS1 in tumor tissues of thyroid cancer patients was remarkably higher than that in adjacent tissues, and the difference was statistically significant.qPCR results indicated that there was a negative correlation between the level of microRNA-129 and DARS-AS1 in thyroid cancer tissues. In addition, cell proliferation and migration ability in the microRNA-129 overexpression group were remarkably decreased. The recovery experiment also found that there was a mutual regulation between DARS-AS1 and microRNA-129, which together affected the malignant progression of thyroid cancer. Compared with patients with low expression of DARS-AS1, patients with high DARS-AS1 expression had a higher incidence of high tumor stage, distant metastasis, and a lower overall survival rate. Yes Besides, compared with NC group, the proliferation and migration ability of shRNA-AS1 expression knockdown group sh-DARS-AS1 was remarkably decreased.  31841198 DARS1-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues regulation[miR-194-5p/DARS signaling] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining However, Gene Expression Profiling Interactive Analysis (GEPIA) and starBase databases revealed the up-regulation of DARS-AS1 in ccRCC. Moreover, DARS was testified as the oncogene in ccRCC and DARS-AS1 worked as a tumor-facilitator in ccRCC through miR-194-5p/DARS signaling. Yes Functional assays including colony formation assay, EdU assay, caspase-3 activity detection, flow cytometry analysis and JC-1 assay were implemented to identify the role of DARS-AS1 in ccRCC. 32526457 DANCR LncRNA Homo sapiens Ovarian Neoplasms ovarian malignant tissues,cell lines Regulation[miR-145/VEGF axis] qRT-PCR DANCR was upregulated in ovarian malignant tissues and ovarian cancer cells.Collectively, DANCR plays a promotional role in tumor angiogenesis in ovarian cancer through regulation of miR-145/VEGF axis. Yes Knockdown of DANCR efficiently impaired ovarian tumor growth through inhibition of tumor angiogenesis. Furthermore, the conditional culture medium from DANCR-knockdown ovarian cells significantly inhibited tube formation and invasion of HUVEC in vitro. 31545000 DANCR LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer cell lines Interaction(miR-335/VEGF-C axis) qRT-PCR//Luciferase Report Assay In this study, DANCR was highly expressed in bladder cancer cell lines. Dual luciferase assay confirmed that DANCR targets miR-335/VEGF-C. Transfection of miR-335 mimic promotes the proliferation, migration, invasion and lymphatic metastasis of bladder cancer cells, overexpression of DANCR eliminates the promotion of miR-335 mimic on bladder cancer cells. Yes Transfection of si-DANCR significantly inhibits the proliferation, migration, invasion and lymphatic metastasis of bladder cancer cells. 33968662 DANCR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells interaction[ sponging miR-216a-5p] qRT-PCR//Luciferase Report Assay Up-regulated DANCR expression and down-regulated miR-216a-5p expression were observed in both OSCC tissues and cells,We concluded that DANCR may promote the growth and metastasis of OSCC cells and suppress OSCC cell apoptosis by sponging miR-216a-5p. Up-regulated DANCR expression and down-regulated miR-216a-5p expression were observed in both OSCC tissues and cells, and they were proven strongly correlated to the histological grade, clinical staging and lymph node metastasis of OSCC patients. Yes Both DANCR shRNA and miR-216a-5p mimic decreased proliferative, migration and invasive abilities of OSCC cells with increased cell apoptosis. However, DANCR group showed completely opposite trends. 32860589 DANCR LncRNA Homo sapiens Endometrial Neoplasms EC tissues Interaction[sponging miR-214] CCK8//qRT-PCR//Luciferase Report Assay//Flow Cytometry DANCR expression was up-regulated in EC tissues as compared to the normal control tissues.DANCR played an important role in promoting tumorigenesis of EC via sponging miR-214. Yes Knockdown of DANCR in AN3CA and HEC-1B cells markedly suppressed cell proliferation and induced cell apoptosis. 31161373 DANCR LncRNA Homo sapiens Osteosarcoma OS tissues,cell lines Interaction[p38MAPK signalling pathway] CCK8//qRT-PCR//EdU Staining//Transwell Assay ANCR was up-regulated in OS cells and tissues.Inhibition of the p38MAPK signalling pathway (SB203580) in MG-63 and U2OS cells rescued si-ANCR-induced inhibition of cell migration and invasion. Yes ANCR silencing significantly inhibited the proliferation rate, decreased the percentage of migration and invasion cells, down-regulated N-cadherin, and up-regulated E-cadherin and p-p38MAPK in MG-63 and U2OS cells. 31727012 DANCR LncRNA Homo sapiens Osteosarcoma osteosarcoma tissue and cells regulation[miR-149/MSI2 axis] qRT-PCR//Western Blot//Transwell Assay DANCR was significantly up-regulated in both osteosarcoma tissue and cells.It may be used as a potential target in the treatment of osteosarcoma in the future, by targeting the miR-149/MSI2 axis to regulate the occurrence and development of osteosarcoma. The high expression of DANCR was significantly positively correlated with tissue typing and advanced TNM stage. Yes DANCR can significantly reduce the migration and invasion of osteosarcoma cells. 32633342 DANCR LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC cells and tissues Regulation[microRNA-33a-5p/AXL signaling pathway ] CCK8//qRT-PCR//Colony Formation Assay DANCR was revealed to promote PDAC progression, with relatively higher expression levels in PDAC cell lines and tissues.Besides, microRNA-33a-5p/AXL signaling pathway may be involved in mediating the function of DANCR. Correlation analysis of the clinicopathological features and DANCR expression found that high DANCR expression was statistically correlated with vascular invasion (P=0.013), advanced T stage (P=0.005), lymph node metastasis (P<0.001) and advanced TNM stage (P<0.001). Notably, survival analysis discovered that high DANCR expression predicted lower OS rate and shorter PFS period. In addition, high DANCR expression was identified as an independent risk factor for poor OS (HR=1.199, 95% CI=1.113-1.290, P<0.001) and PFS (HR=1.199, 95% CI=1.114-1.290, P<0.001) of PDAC. Yes Moreover, in vitro assays detected that the migration and invasion of Panc1 cells with DANCR deficiency were significantly suppressed in the Transwell assay and the Matrigel assay. However, the motility of BxPC3 cells with DANCR overexpression was obviously increased. In addition, the loss of DANCR suppressed the proliferation of Panc1 cells in the CCK-8 assay and the colony formation assay, while ectopic expression of DANCR in BxPC3 cells promoted the proliferation. 30519037 DANCR LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells Interaction[sponging miR-335-5p] qRT-PCR In this study, we discovered that DANCR was significantly elevated in cervical cancer tissues and cells, and was closely correlated with poor prognosis of cervical cancer patients. In summary, this study demonstrated that DANCR promoted cervical cancer progression by functioning as a competing endogenous RNA (ceRNA) to regulate ROCK1 expression via sponging miR-335-5p, suggesting a novel potential therapeutic target for cervical cancer. In this study, we discovered that DANCR was significantly elevated in cervical cancer tissues and cells, and was closely correlated with poor prognosis of cervical cancer patients. Yes In addition, knockdown of DANCR inhibited proliferation, migration, and invasion of cervical cancer cells in vitro, indicating that DANCR functioned as an oncogene in cervical cancer. 30362591 DANCR LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines regulation[Wnt/β-catenin signaling pathway] CCK8//qRT-PCR//EdU Staining//Western Blot DANCR is increased in cervical cancer tissues and cell lines.Our findings suggest DANCR as an oncogenic lncRNA in cervical cancer through activating the Wnt/β-catenin signaling pathway, and imply that DANCR may be a promising prognostic biomarker and therapeutic target for cervical cancer. Increased expression of DANCR is associated with large tumor size, advanced FIGO stage, and poor overall survival of cervical cancer patients. Yes Functional experiments showed that enhanced expression of DANCR promotes cervical cancer cell proliferation in vitro and xenograft growth in vivo. Conversely, DANCR knockdown inhibits cervical cancer cell proliferation in vitro and xenograft growth in vivo. 32123519 DANCR LncRNA Homo sapiens Uterine Cervical Neoplasms 112 cases of CC tissues  Interaction(microRNA-145-3p/ZEB1 axis) In Vivo Experiment//ChIP//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay KLF5, DANCR, and ZEB1 were upregulated but miR-145-3p was downregulated in CC tissues. KLF5 activated DANCR expression and the high DANCR expression was related to tumor staging, infiltrating muscle depth and lymphatic metastasis of CC patients. MiR-145-3p was targeted by DANCR and ZEB1 was targeted by miR-145-3p. KLF5 activated DANCR expression and the high DANCR expression was related to tumor staging, infiltrating muscle depth and lymphatic metastasis of CC patients.  Yes Reduced DANCR or elevated miR-145-3p repressed malignant behaviors of CC cells. The tumor diameter and weight were also repressed by DANCR silencing or miR-145-3p elevation.  34233586 DANCR LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and breast cancer cells Interaction[targetting miR-216a-5p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay Our results showed that DANCR was up-regulated in TNBC tissues and breast cancer cells compared with normal breast tissues and cells. To deeply understand its molecular mechanism, miRNA-216a-5p was identified as a target of DANCR by bioinformatic analysis. Experiments demonstrated that miRNA-216a-5p interacted with DANCR and its inhibitor could weaken the influences induced by DANCR knockdown for cancer cells, including cell proliferation and invasion, and the expression of Nanog, SOX2, and OCT4. Therefore, DANCR might act as a tumor promoter by targetting miRNA-216a-5p, which might provide a potential therapy target for breast cancer treatment. Yes Further study indicated that DANCR overexpression significantly promoted cell proliferation and invasion in vitro and contributed to tumor growth in vivo 30910842 DANCR LncRNA Homo sapiens Glioma glioma tissues and cells interaction[miR-33a-5p] qRT-PCR The results showed that LncRNA DANCR was increased in glioma tissues and cells compared with normal brain tissues and cells.In tumor tissues, knockdown of DANCR increased the expression of miR-33a-5p, reduced EMT and increased apoptosis. DANCR expression was positively correlated with the malignancy and poor prognosis of glioma patients. Yes Knockdown of DANCR remarkably reduced the increase of tumor volumes in xenograft mouse models. 29940760 DANCR LncRNA Homo sapiens Glioma glioma tissues and cell lines interaction[EZH2,PTEN] qRT-PCR//RNA Pull-Down//RIP Our results indicated that ANCR and EZH2 were upregulated and PTEN was downregulated in glioma tissues and cell lines. In conclusion, we have found that restrained ANCR could repress invasion, migration, and proliferation, as well as promote apoptosis of glioma cells through interacting with EZH2 and regulating the expression of PTEN, offering an effective therapeutic target for patients with glioma. Yes Inhibited ANCR, reduced EZH2, or elevated PTEN could reduce the ability of invasion, migration, and proliferation, and promote apoptosis of glioma cells. 33293663 DANCR LncRNA Homo sapiens Glioma glioma tissues and cell lines (U251, U118, LN229, and U87MG) Interaction(miR-634/RAB1A ) Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay Our results showed that DANCR was significantly up-regulated in glioma tissues and cell lines (U251, U118, LN229, and U87MG). In addition, we verified that DANCR could directly interact with miR-634 in glioma cells and this interaction resulted in the inhibition of downstream of RAB1A expression. The present study demonstrated that DANCR/miR-634/RAB1A axis plays crucial roles in the progression of glioma, and DANCR might potentially serve as a therapeutic target for the treatment of glioma patients. High DANCR expression was correlated with advanced tumor grade. Yes Inhibition of DANCR suppressed the glioma cells proliferation and induced cells arrested in the G0/G1 phase. 29301870 DANCR LncRNA Homo sapiens Nasopharyngeal carcinoma cell lines Expression[highly expressed] CCK8//qRT-PCR//Wound Healing Assay//Colony Formation Assay Reverse transcription‑quantitative polymerase chain reaction results suggested that DANCR was significantly upregulated in NPC cells. Yes Overexpression of DANCR promoted 5‑8F cell proliferation and migration, as detected by Cell Counting Kit‑8, colony formation and wound healing assays. DANCR knockdown suppressed cell proliferation and migration, and promoted cell apoptosis in SUNE‑1 cell. Knockdown of DANCR decreased tumor growth in a xenograft model following subcutaneous injection of SUNE‑1 cells. 30720067 DANCR LncRNA Homo sapiens Nasopharyngeal carcinoma cell lines Regulation[IL-6/JAK1/STAT3 signaling] RNA Pull-Down//Western Blot//Co-IP//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Invasion Assay//ChIP In the current study, we investigated the expression and biological functions of DANCR in NPC cells and found that DANCR is highly expressed in NPC cells and IL-6 stimulation upregulates DANCR expression through an STAT3-dependent manner. Taken together, the present study for the first time demonstrates that DANCR, acting as an oncogene in NPC, promotes NPC progression by interacting with STAT3 and enhancing JAK1 binding to STAT3 to strengthen IL-6/JAK1/STAT3 signaling, suggesting that it may be a potential target to be used as a novel strategy to develop NPC therapeutics. Yes Besides, DANCR knockdown attenuates IL-6-induced proliferation and invasion of NPC cells. 30849642 DANCR LncRNA Homo sapiens Atherosclerosis blood samples of AS patients, VSMCs and HUVECs Interaction(miR-214-5p/COX20 signaling pathway) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//ELISA DANCR was significantly increased in the blood samples of AS patients and ox-LDL treated VSMCs and HUVECs. DANCR regulated COX20 expression by acting as a competing endogenous RNA (ceRNA) of miR-214-5p. Rescue experiments demonstrated that miR-214-5p downregulation obviously attenuated si-DANCR-induced protective effects on ox-LDL-caused endothelial injury. Yes DANCR downregulation obviously increased viability and reduced apoptosis of ox-LDL-treated VSMCs and HUVECs. Meanwhile, DANCR downregulation reduced the levels of inflammatory cytokines, including interleukin (IL)-6 (IL-6), IL-1beta (IL-1β), IL-6 and tumor necrosis factor (TNF)-alpha (TNF-α) and MDA while increasing the SOD level in ox-LDL-treated VSMCs and HUVECs. 35177003 DANCR LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines Interaction[Sponging miR-214-5p] CCK8//qRT-PCR//Western Blot//Transwell Assay DANCR was markedly upregulated in clinical tissues and cell lines of PC. Furthermore, DANCR acted as sponge to regulate miR-214-5p, and miR-214-5p inhibitor reversed the effects of DANCR knockdown on PC cells. Moreover, DANCR positively modulated E2F2 expression through miR-214-5p in PC cells. High DANCR expression exhibited a significant correlation with poor prognosis. Yes DANCR knockdown inhibited growth and metastasis of PC cells. 31213582 DANCR LncRNA Homo sapiens Ovarian Neoplasms Ovarian Cancer tissues Interaction[Expression[Expression[highly expressed]-expression]F1] qRT-PCR//RIP DANCR was Expression[Expression[up-expression]-expression]regulated in OC tissues and cell lines.Expression[Expression[up-expression]-expression]F1 was found to be Expression[down-expression]regulated in OC tissues and negatively correlated to DANCR. DANCR was mainly distributed in the cytoplasm and interacted with Expression[Expression[up-expression]-expression]F1. Yes Overexpression of DANCR accelerated HO8910 and HEY cells to proliferate and migrate. 31858532 DANCR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell Interaction(miR-125b-5p) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay In HCC cells, DANCR was highly expressed and miR-125b-5p was decreased. evels of p-p38/p38, p-ERK1/2/ERK1/2, and p-JNK/JNK were suppressed by sh-DANCR and miR-125b-5p mimic. LncRNA DANCR negatively targeted and directly bound to miR-125b-5p. Knockdown of miR-125b-5p could reverse the inhibitory effects of sh-DANCR on HCC cells. Yes sh-DANCR or miR-125b-5p mimic stimulation reduced HepG2 or Huh-7 cell progression while promoted cell apoptosis evidenced by increased apoptotic rate, elevated levels of Bax and cleaved-caspase-3, and decreased Bcl-2. Moreover, the migration rate and invasiveness of HCC cells were also inhibited by sh-DANCR and miR-125b-5p mimic. 33272103 DANCR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[HNRNPA1 ] RNA Pull-Down//qRT-PCR//RIP//Luciferase Report Assay//ChIP The results indicated that ANCR was highly expressed in HCC tissues and cells, which promoted the proliferation and migration/invasion of HCC cells. In conclusion, ANCR promoted HCC metastasis by upregulating HNRNPA1, inhibiting HNRNPA1 degradation and sponging miR-140-3p. Yes The results indicated that ANCR was highly expressed in HCC tissues and cells, which promoted the proliferation and migration/invasion of HCC cells. 31868085 DANCR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[DANCR/miR-138/Sox4] ChIP//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Transwell Assay Here, we demonstrated that differentiation antagonizing noncoding RNA (DANCR) was overexpressed in NSCLC tissues. In addition, we found that Sox4 bound to the promoter regions of DANCR gene to activate DANCR expression, suggesting a positive feedback loop of DANCR/miR-138/Sox4 in NSCLC. Upregulation of DANCR expression was significantly associated with larger tumor size, advanced TNM stage and lymph node metastasis, and also predicted poor prognoses of patients with NSCLC. Yes Functional experiments showed that DANCR enhanced NSCLC growth and metastasis both in vitro and in vivo. 30906628 DARS1-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cell lines Interaction(miR-188-5p/ KLF12 axis) Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//BrdU//Colony Formation Assay//Invasion Assay Cell functional experiments revealed that lncRNA DARS-AS1 participated in enhancing LUAD proliferation, invasion, and migration by inhibiting miR-188-5p. The investigation on DARS-AS1/miR-188-5p led to the discovery of KLF12 as a downstream target of miR-188-5p, and the regulatory pathway was established as DARS-AS1/miR-188-5p/KLF12. Yes Cell functional experiments revealed that lncRNA DARS-AS1 participated in enhancing LUAD proliferation, invasion, and migration by inhibiting miR-188-5p. The investigation on DARS-AS1/miR-188-5p led to the discovery of KLF12 as a downstream target of miR-188-5p, and the regulatory pathway was established as DARS-AS1/miR-188-5p/KLF12. 34644678 DANCR LncRNA Homo sapiens Stomach Neoplasms Gastric Cancer Tissue regulation[FoxO1 ] RNA Pull-Down//Western Blot//qRT-PCR//RIP//ELISA//Transwell Assay LncRNA ANCR was highly expressed in GC. Based on these results, the overexpression of LncRNA ANCR promoted the invasion and metastasis of GC cells via down-regulating FoxO1 to inhibit macrophage polarization to M1. Yes The overexpression of LncRNA ANCR in macrophages reduced the concentrations of M1 macrophage polarized marker molecules IL-1β and IL-6 in the supernatant of cells, and inhibited the polarization of macrophages to M1, while the knockdown of LncRNA ANCR produced the opposite effect. 31894487 DANCR LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells regulation[miR-4319/VAPB axis] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay DANCR and VAPB were upregulated, while miR-4319 was downregulated in breast cancer tissues and cells. DANCR facilitated breast cancer cell progression through regulating the miR-4319/VAPB axis, indicating that DANCR might be a potential biomarker and therapeutic target for breast cancer treatment. Yes Knockdown of DANCR hindered proliferation, migration, and invasion and promoted apoptosis of breast cancer cells. 32818383 DANCR LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines regulation[DANCR-miR-758-3p-PAX6] qRT-PCR DANCR and PAX6 were up-regulated in BC tissues and cell lines, while miR-758-3p was opposite. DANCR-miR-758-3p-PAX6 molecular network plays a key regulatory role in BC cell apoptosis and autophagy, which may provide reference for treating patients. Yes Down-regulating DANCR inhibited the malignant proliferation of BC cells and also promoted apoptosis and autophagy, which showed that caspase-3, caspase-9, Bax/Bcl-2, LC3B, Atg5 transcription and protein levels increased, while Beclin-1 transcription and protein levels decreased. 32581581 DANCR LncRNA Homo sapiens Breast Neoplasms breast cancer tissue,cell lines regulation[SOCS3 ] qRT-PCR//MTT//ELISA//Transwell Assay//ChIP DANCR was significantly up-regulated in tissue samples from patients with breast cancer, as well as in breast cancer cell lines, as compared with normal tissues and breast epithelial cells, respectively. Mechanistically, DANCR promoted the binding of enhancer of zeste homolog 2 (EZH2) to the promoter of SOCS3, thereby epigenetically inhibiting SOCS3 expression. The highest DANCR expression levels were associated with advanced tumor grades or lymph node metastasis. Yes DANCR was necessary and sufficient to control multiple malignant phenotypes of breast cancer cells in vitro and xenograft growth in vivo. 31860165 DANCR LncRNA Homo sapiens Breast Neoplasms Forty-eight breast cancer and paracancerous tissue samples, cell lines Interaction(miR-331) Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of lncRNA ANCR in breast cancer tissue was significantly lower than that in adjacent normal tissue (p < 0.05). LncRNA ANCR was lowly expressed in various human breast cancer cell lines, being lowest in high-metastatic cell line (MDA-MB-231HM) (p < 0.05). ANCR bound miR-331 targetedly, and the former negatively regulated the expression of the latter. Yes Silencing lncRNA ANCR significantly enhanced the proliferation and invasion capacities of breast cancer cells, and promoted their tumor formation abilities in nude mice (p < 0.05).  34783641 DANCR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung biopsies and plasma Regulation[ TGF-β Pathway] qRT-PCR//Western Blot//Transwell Assay ANCR was significantly downregulated in NSCLC patients compared with healthy controls in lung biopsies and plasma. ANCR can inhibit NSCLC cell migration and invasion by downregulating TGF-β1 expression. Downregulated expression of ANCR distinguishes NSCLC patients from healthy controls and low NSCLC expression level indicates shorter postoperative survival time of NSCLC patients. Yes ANCR overexpression inhibited NSCLC cell migration and invasion and downregulated TGF-β1 expression, while TGF-β1 treatment showed no significant effects on ANCR expression but promoted NSCLC cell migration and invasion. 30154397 DANCR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung A549 and NCI-H1299 cells Regulation qRT-PCR//Western Blot Over 90% DANCR silencing was observed along with inhibition of cell migration, invasion, and spheroid formation relative to transfection with negative control siRNA in RGD-PEG-ECO nanoparticles. DANCR knockdown further showed efficacy in reducing migration and invasion of epidermal growth factor receptor (EGFR)-inhibitor resistant NSCLC along with resensitization to the inhibitor. Yes Over 90% DANCR silencing was observed along with inhibition of cell migration, invasion, and spheroid formation relative to transfection with negative control siRNA in RGD-PEG-ECO nanoparticles. DANCR knockdown further showed efficacy in reducing migration and invasion of epidermal growth factor receptor (EGFR)-inhibitor resistant NSCLC along with resensitization to the inhibitor. 35811871 DANCR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and HCC cells regulation[Wnt/β-Catenin Signaling Pathway] Western Blot//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay Our results showed that ANCR was lowly expressed in both HCC tissues and HCC cells.Our study demonstrated that ANCR can suppress cell proliferation, migration and invasion, as well as promote apoptosis of HCC cells via modulation of the Wnt/β-catenin signaling pathway. ANCR expression was closely associated with tumor size, tumor-node-metastasis (TNM) stages and vascular invasion in HCC. Yes ANCR could dramatically inhibit cell proliferation, migration and invasion, as well as promote apoptosis in MHCC97H and HCCLM3 cells. 32982283 DANCR LncRNA Homo sapiens Lung Neoplasms lung cancer tissue Expression[highly expressed] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP Compared with paracancerous tissue, ANCR expression in lung cancer tissue significantly increased, and FOXO1 significantly decreased (P<0.01), being negatively correlated (P<0.01). The patients with higher TNM stage, lower differentiation degree and lymph node metastasis had higher relative expression of ANCR lncRNA. Yes Compared with the NC group, sh-ANCR lncRNA and FOXO1 groups had fewer proliferative cells, more significant arrest in the G0/G1 phase, more apoptotic cells, increased expressions of Bax and P27, and reduced expressions of Bcl-2 and cyclin D1 (P<0.05). Compared with the sh-ANCR lncRNA group, the above results of the sh-ANCR lncRNA + sh-FOXO1 group were reversed (P<0.05). 35117833 DANCR LncRNA Homo sapiens Lung Neoplasms high-grade lung cancer tissues and aggressive cancer cells Interaction(miR-216a) qRT-PCR//RNA Pull-Down//Colony Formation Assay DANCR upregulation was seen in lung cancer, particularly in high-grade lung cancer tissues and aggressive cancer cells. The miR-216a level in cancer cells was negatively correlated with DANCR expression. Yes Ectopic DANCR expression induced lung cancer cell proliferation and colony formation, whereas DANCR silencing induced opposing effects. The miR-216a level in cancer cells was negatively correlated with DANCR expression. 29651883 DANCR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-185-5p/HMGA2 axis) Western Blot//Wound Healing Assay//qRT-PCR//RIP//Transwell Assay In this study, we demonstrated that the expression of DANCR was elevated in CRC tissues and cell lines, and its high expression was significantly associated with increased TNM stage and positive lymph node metastasis. DANCR was further identified as a molecular sponge for miR-185-5p, and DANCR could indirectly increase the expression of HMGA2 via repressing miR-185-5p. In conclusion, DANCR/miR-185-5p/HMGA2 axis participated in the progression of CRC. In this study, we demonstrated that the expression of DANCR was elevated in CRC tissues and cell lines, and its high expression was significantly associated with increased TNM stage and positive lymph node metastasis. Yes DANCR overexpression promoted CRC cell proliferation, migration, invasion and cell cycle progression, but inhibited apoptosis; while knocking down DANCR caused the opposite effects. 33481014 DANCR LncRNA Homo sapiens Colonic Neoplasms CC tissues and cell lines regulation[DANCR/microRNA-518a-3p/MDMA] qRT-PCR DANCR was highly-expressed in CC tissues and cell lines, and higher levels of DANCR were linked with worse prognosis and less survival time of CC patients.This study provided evidence that silencing of DANCR might inhibit the growth and metastasis of CC cells through the DANCR/miR-518a-3p/MDM2 ceRNA network and the defect of Smad2/3 while activation of the p53 signaling pathways. DANCR was highly-expressed in CC tissues and cell lines, and higher levels of DANCR were linked with worse prognosis and less survival time of CC patients. Yes Silencing of DANCR inhibited proliferation, viability, metastasis and resistance to death of CC cells. 32423468 DANCR LncRNA Homo sapiens Osteoarthritis OA tissues and cells Interaction(miR-577/SphK2 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay The present study found that DANCR was significantly upregulated in patients with OA. The study also showed that DANCR acted as a competitive endogenous RNA to sponge miR-577, which targeted the mRNA of SphK2 to regulate the survival of OA chondrocytes. Yes Functional assays demonstrated that DANCR inhibition suppressed the proliferation of OA chondrocytes and induced cell apoptosis. 29678573 DANCR LncRNA Homo sapiens Carcinoma, Hepatocellular Interaction[ROCK1/LIMK1/COFILIN1 pathway] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay The results of qRT-PCR and bioinformatic analysis revealed the high expression of DANCR in HCC. Next, the antineoplastic effect of miR-27a-3p on cell growth and motility of HCC was confirmed. In addition, we clarified that DANCR acted as a ceRNA to decoy miR-27a-3p via mediating ROCK1/LIMK1/COFILIN1 pathway. In the end, we validated that DANCR/miR-27a-3p axis regulates EMT progression by cell immunofluorescence and Western blot. Yes DANCR accelerated proliferation and metastasis of HCC cells and the knockdown of DANCR had the opposite effect. Meanwhile, xenograft tumours in sh-DANCR group grow slower and have smaller volumes compared with negative control group. 31038266 DANCR LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Interaction[targeting miR-216a-5p and KLF12] qRT-PCR We found that DANCR was significantly upregulated in HCC cell lines in comparison to LO2 cells.Here, the correlation between miR-216a-5p and DANCR was confirmed using dual-luciferase reporter assay and radioimmunoprecipitation assay. Subsequently, Kruppel-like factor 12 (KLF12) exerts an important role in different tumor types. KLF12 can function as a downstream target of miR-216a-5p. Yes Then, we observed that knockdown of DANCR could greatly inhibit Huh7 and HepG2 cell proliferation. In addition, HCC cell apoptosis was increased by silence of DANCR and meanwhile, cell cycle progression was blocked in G1 phase. Apart from these, downregulation of DANCR repressed HCC cell migration and invasion ability obviously.Finally, the in vivo experiments were used and the data proved that DANCR also strongly suppressed HCC tumor growth in vivo via targeting miR-216a-5p and KLF12. 30430564 DGCR5 LncRNA Mus musculus Chronic Sciatic Nerve Injury dorsal spinal cord Regulation[DGCR5/miR-330-3p/PDCD4 axis] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//ELISA Here, it was observed that DGCR5 was significantly decreased in chronic sciatic nerve injury (CCI) rat models. Taken these together, it was implied that DGCR5/miR-330-3p/PDCD4 axis participated in neuropathic pain treatment. Yes DGCR5 overexpression was able to alleviate neuropathic pain development including mechanical and thermal hyperalgesia. 30317600 DGCR5 LncRNA Homo sapiens Prostatic Neoplasms PC Tissues Interaction[TGF-β1] qRT-PCR//Western Blot we found that DGCR5 was Expression[down-expression]-regulated in tumor tissues than in adjacent healthy tissues of PC patients.DGCR5 and TGF-β1 were inversely correlated in tumor tissues but not in adjacent healthy tissues. DGCR5 expression was not affected by clinical stages, but low DGCR5 level in the tumor was correlated with poor survival. Yes DGCR5 over-expression resulted in Expression[down-expression]-regulation of TGF-β1, while TGF-β1 treatment did not significantly affect DGCR5 expression. DGCR5 over-expression led to decreased stemness of PC cells, but TGF-β1 treatment played a reverse role and attenuated the effects of DGCR5 over-expression. 31920375 DLGAP1-AS2 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(Six3/Wnt1/β-catenin signaling axis) IHC//Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//ChIP In agreement with previous studies, our findings demonstrated that DLGAP1-AS2 was significantly up-regulated in GC and its high expression was associated with poor prognosis, suggesting that DLGAP1-AS2 might be a putative oncogenic lncRNA of GC.Taken together, our results suggest that DLGAP1-AS2 functions as an oncogenic factor by directly interacting with Six3 to relieve its suppression on Wnt1 expression, thereby driving the malignancy of GC. DLGAP1-AS2/Six3/Wnt1/β-catenin signaling axis might serve as a promising diagnostic and therapeutic target for GC. In agreement with previous studies, our findings demonstrated that DLGAP1-AS2 was significantly up-regulated in GC and its high expression was associated with poor prognosis, suggesting that DLGAP1-AS2 might be a putative oncogenic lncRNA of GC. Yes Loss of DLGAP1-AS2 restricted cell proliferation, migration, and invasion in GC cell lines. 34545072 DLEU2 LncRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(RARB /MAPK) qRT-PCR//Transwell Assay//RIP//ChIP DLEU2 was highly expressed in CRC according to the bioinformatic analysis and its high expression was detected in CRC cells compared to the normal colon epithelial cells (FHC). Retinoic acid receptor beta (RARB) expression was elevated in cells after DLEU2 downregulation. The promoter methylation of RARB was enhanced in CRC cells compared to normal FHC cells. DLEU2 induced promoter methylation of RARB to downregulate its expression. Further silencing of RARB restored proliferation and invasiveness of cells blocked by sh-DLEU2. Upregulation of DLEU2 activated the mitogen activated kinase-like protein (MAPK) signaling pathway to trigger CRC progression. Yes Downregulation of DLEU2 in CRC SW480 and HT29 cells suppressed viability, migration, invasiveness, and resistance to apoptosis of cells. 35611845 DLEU2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue samples and cell line Interaction(miR-30a-5p/PTP4A1 axis) qRT-PCR As a consequence, we found that lncRNA DLEU2 was upregulated in HCC tissue samples and associated with distant metastasis and poor survival in patients with HCC. Furthermore, lncRNA DLEU2 harbored a negative correlation and specific binding with miR-30a-5p in HCC cells. Knockdown of lncRNA DLEU2 upregulated miR-30a-5p, but downregulated its target PTP4A1, and miR-30a-5p abrogated lncRNA DLEU2-induced tumor-promoting effects and PTP4A1 upregulation. As a consequence, we found that lncRNA DLEU2 was upregulated in HCC tissue samples and associated with distant metastasis and poor survival in patients with HCC. Yes Knockdown of lncRNA DLEU2 impaired HCC cell proliferation, colony formation and invasion, but ectopic expression of lncRNA DLEU2 abolished these effects. 36049439 DLEU2 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells interaction[miR-337-3p] qRT-PCR//Luciferase Report Assay//RIP In osteosarcoma tissues and cells, DLEU2 expression level was raised remarkably in comparison with that in para-carcinoma normal tissues, and DLEU2 high expression had associations with poor prognosis, tumour stages, and TS of osteosarcoma cases.This study is the first to demonstrate the roles of DLEU2 in osteosarcoma and revealed that DLEU2 may serve as a ceRNA to sponge miR-337-3p and then promote the progression of osteosarcoma, providing a potential therapeutic target for osteosarcoma. In osteosarcoma tissues and cells, DLEU2 expression level was raised remarkably in comparison with that in para-carcinoma normal tissues, and DLEU2 high expression had associations with poor prognosis, tumour stages, and TS of osteosarcoma cases. Yes Cell migration ability and viability were blocked by DLEU2 knockdown but enhanced by ectopic DLEU2 expression in vitro and in vivo. 32196715 DLEU2 LncRNA Homo sapiens Esophageal Neoplasms EC tissues Regulation[miR-30e-5p/E2F7 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay With the help of GEPIA analysis, we observed that lncRNA DLEU2 was up-regulated in EC tissues and associated with poor prognosis. Yes Loss-of-function assay showed that silencing lncRNA DLEU2 inhibited the proliferation, migration and invasion of EC cells, and induced apoptosis by regulating the Bcl-2/Bax axis and Caspase cascade. Overexpression of lncRNA DLEU2 increased the proliferation, migration and invasion abilities of TE-1 cells, as well as decreased cell apoptosis. 31884338 DLEU2 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tumor tissues interaction[Targeting miR-128-3p] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay We demonstrated that DLEU2 was upregulated in cervical cancer tumor tissues. Taken together, these results suggested knockdown of DLEU2 inhibited cervical cancer progression via targeting miR-128-3p. Yes Downregulation of DLEU2 inhibited cell proliferation, induced apoptosis and cell cycle arrest at G2/M phase of cervical cancer cells in vitro, and suppressed tumor growth in vivo. 33116599 DLEU2 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Interaction(ZFP36) Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//migration assay//RNA-seq//Cell Proliferation Assay//Colony Formation Assay Here, the results of RNA microarray and RNA-sequencing dataset analysis showed that lncRNA DLEU2 was significantly upregulated in CC tissues. Mechanistically, lncRNA DLEU2 promoted the progression of the cell cycle and inhibited the activity of the Notch signaling pathway by inhibiting p53 expression. Additionally, lncRNA DLEU2 probably interacted with ZFP36 Ring Finger Protein (ZFP36) to inhibit the expression of p53. Yes Functional experiments and bioinformatics analysis revealed that lncRNA DLEU2 promoted CC cell proliferation and accelerated the cell cycle. 33675808 DLEU2 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues and cell lines Interaction(miR-205-5p/TNFAIP8 axis) In Vivo Experiment//Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Bioinformatics Analysis//Transwell Assay DLEU2 and tumor necrosis factor-α-induced protein 8 (TNFAIP8) were highly expressed in thyroid cancer tissues and cell lines. DLEU2/miR-205-5p/TNFAIP8 signaling axis was identified in thyroid cancer cells. Yes DLEU2 and TNRAIP8 promoted the proliferation, migration and aerobic glycolysis and restrained the apoptosis of thyroid cancer cells. 33764889 DLEU2 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and PC cell lines Interaction[upregulating microRNA-455] CCK8//qRT-PCR//Western Blot In this study, we found that the DLEU2 level was substantially upregulated in PC tissues and PC cell lines, and significantly associated with poor clinical outcomes in PC patients. Furthermore, bioinformatics analysis, luciferase reporter assay, and RNA immunoprecipitation assay revealed that DLEU2 directly bond to microRNA-455 (miR-455) and functioned as an endogenous sponge for miR-455, which could remarkably suppress cell growth and invasion. We also determined that SMAD2 was a direct target of miR-455, and the restoration of SMAD2 rescued cell growth and invasion that were reduced by DLEU2 knockdown or miR-455 overexpression. In addition, low miR-455 expression and high SMAD2 expression was correlated with poor patient survival. These results indicate that DLEU2 is an important promoter of PC development, and targeting the DLEU2/miR-455/SMAD2 pathway could be a promising therapeutic approach in the treatment of PC. Yes Overexpression of DLEU2 significantly induced PC cell proliferation and invasion, whereas knockdown of DLEU2 impaired cell proliferation and invasion in vitro. 30838724 DLEU2 LncRNA Homo sapiens Idiopathic Pulmonary Fibrosis IPF tissues Interaction(miR‑369‑3p / TRIM2) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//IHC//IF As a result, DLEU2 expression was found to be upregulated in IPF and in transforming growth factor (TGF)‑β1‑stimulated A549 cells. DLEU2 directly targeted miR‑369‑3p. The effect of the silencing of DLEU2 on TGF‑β1‑stimulated A549 cells was suppressed by the silencing of miR‑369‑3p. TRIM2 was the target protein of miR‑369‑3p. Yes The silencing of DLEU2 inhibited the TGF‑β1‑induced proliferation, migration and epithelial‑mesenchymal transition (EMT) of A549 cells and bleomycin (BLM)‑induced pulmonary fibrosis in mice. 33760118 DLEU2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCCs tissues regulation[miR-30c-5p/PIK3CD/Akt axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC//EdU Staining We found that DLEU2 was significantly upregulated and predicted poor clinical outcomes in LSCC patients.DLEU2 and its targeted miR-30c-5p/PIK3CD/Akt axis may represent valuable prognostic biomarkers and therapeutic targets for LSCCs. Yes In addition, ectopic overexpression of DLEU2 promoted the proliferation and migration of LSCC cells both in vivo and in vitro. 32555190 DLEU2 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Interaction(miR-582-5p/SGK1 axis) In Vivo Experiment//ChIP//Western Blot//Transfection//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay Our results showed that DLEU2 was upregulated in advanced prostate cancer tissues. Mechanistically, DLEU2 promoted serum and glucocorticoid-induced protein kinase 1 (SGK1) expression by acting as an miR-582-5p sponge, and the transcription of DLEU2 was activated by the dysregulation of E2F transcription factor 2 (E2F2) expression in prostate cancer. Furthermore, knockdown of DLEU2 attenuated prostate cancer tumorigenesis in vivo. Patients with prostate cancer displaying high expression of DLEU2 had a poor prognosis. Yes Moreover, we demonstrated that overexpression of DLEU2 facilitated the proliferation, migration, and invasion of prostate cancer in vitro. 35075115 DLEU2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[sponging miR-30a-5p] Western Blot//FISH//RIP//qRT-PCR//Transwell Assay Herein, the expression of lncRNA DLEU2 was elevated in NSCLC tissues.Furthermore, lncRNA DLEU2 harboured a negative correlation with miR-30a-5p expression in NSCLC tissues and acted as a sponge of miR-30a-5p, which reversed the tumour-promoting effects of lncRNA DLEU2 by targeting putative homeodomain transcription factor 2 in NSCLC. Altogether, lncRNA DLEU2 promoted the tumorigenesis and invasion of NSCLC by sponging miR-30a-5p. Yes Silencing of lncRNA DLEU2 repressed the tumorigenesis and invasive potential of NSCLC, whereas re-expression of lncRNA DLEU2 showed the opposite effects. 31721438 DLEU2 LncRNA Homo sapiens Mouth Neoplasms OC cells Interaction(miR-30a-5p/RAP1B Axis) Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Microarray//Invasion Assay//Transwell Assay Our research shows that, in contrast to miR-30a-5p, DLEU2 or RAP1B was upregulated in OC cells, and high expression of DLEU2 or RAP1B was associated with poorer overall survival.miR-30a-5p was predicted to interact with DLEU2 or RAP1B by bioinformatics, and dual-luciferase analysis confirmed this interaction. Notably, si-DLEU2 suppressed RAP1B expression and protein level, and after overexpression of RAP1B in OC cells, reversal of suppressed DLEU2 expression was observed. Our research shows that, in contrast to miR-30a-5p, DLEU2 or RAP1B was upregulated in OC cells, and high expression of DLEU2 or RAP1B was associated with poorer overall survival. Yes Inhibiting the expression of DLEU2 slowed the proliferation and reduced the ability of migration and invasion of Tca8113 and CAL-27 cells. 36277988 DLEU2 LncRNA Homo sapiens Wilms Tumor Wilm's tumor tissues and in vitro cell lines Interaction(miR-539-3p/HOXB2 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Transwell Assay DLEU2 and HOXB2 were significantly highly expressed in primary Wilm's tumor tissues and in vitro cell lines.MiR-539-3p was confirmed to be a target of DLEU2. DLEU2 silencing inhibited the malignant behaviors of Wilm's tumor cells by releasing miR-539-3p. In addition, HOXB2 was a target of miR-539-3p. Overexpression of HOXB2 partially restored the inhibitory effects of miR-539-3p on Wilm's tumor cell malignant behaviors. Yes Silencing of DLEU2 reduced the proliferation, migration and invasion of Wilm's tumor cells, and promoted cell apoptosis. Animal experiments also confirmed the anti-tumor effects of DLEU2 silencing in vivo. 36209036 DLEU1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[DLEU1/microRNA-300/RAB22A axis] qRT-PCR//Luciferase Report Assay//Western Blot//Transwell Assay DLEU1 expression remains higher in breast cancer tissues than in normal adjacent tissues, and has a certain diagnostic value. Dual-luciferase reporter gene assay confirmed that DLEU1 and RAB22A could bind to microRNA-300. Further verification showed that RAB22A expression was positively regulated by DLEU1, but negatively regulated by microRNA-300. Finally, we found that DLEU1 overexpression could reverse the inhibitory effects of microRNA-300 on proliferation, migration, and EMT of breast cancer cells. The overall survival of breast cancer patients was negatively correlated with DLEU1 expression. Yes Overexpression of DLEU1 or RAB22A, or microRNA-300 knockdown could enhance the migratory and invasive capacities, as well as increase EMT ofBT549 cells. On the contrary, knockdown of DLEU1 or RAB22A, or microRNA-300 overexpression in MCF-7 cells obtained the opposite trends of cellular behaviors. 31841195 DLEU1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Regulation(HIF-1α/CKAP2 ) In Vivo Experiment//RNA Pull-Down//Transwell Assay//RIP//Colony Formation Assay//ChIP We demonstrated that up-regulation of DLEU1 was detected in breast cancer tissues and cells, particularly in tumors of higher malignancy. Mechanistically, DLEU1 interacted with HIF-1α to collectively activate the transcription of CKAP2. By activating ERK and STAT3 signaling, CKAP2 essentially mediated the pro-tumor activities of DLEU1. Yes DLEU1 knockdown inhibited the growth and the motility of breast cancer cells. 35853854 DLEU1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues Expression[highly expressed] Western Blot//Wound Healing Assay//EdU Staining//qRT-PCR//RIP//Invasion Assay The expression of DLEU1 was up-regulated in NSCLC tumor tissues.DLEU1 overexpression promoted the proliferation, migration, and invasion, but inhibited the apoptosis of NSCLC cells by upregulating CDK1 expression, binding with SRC and altering the expression of P70(S6K), MMP2 and E-cadherin. Yes DLEU1 overexpression promoted the proliferation, migration, and invasion, but inhibited the apoptosis of NSCLC cells by upregulating CDK1 expression, binding with SRC and altering the expression of P70(S6K), MMP2 and E-cadherin. Besides, xenograft tumors in nude mice demonstrated that DLEU1 overexpression accelerated tumor growth. 30551552 DLEU1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissue and cells Interaction(DLEU1/DYNLL1 axis ) RNA Pull-Down//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay In a screen for differentially expressed lncRNAs in ESCC, we determined that DLEU1 was one of the most overexpressed lncRNAs in ESCC tissues and that upregulated DLEU1 expression was associated with a worse prognosis. Mechanistically, DLEU1 could bind and stabilize DYNLL1 by interfering with RNF114-mediated ubiquitination and proteasomal degradation. The DLEU1/DYNLL1 axis subsequently upregulated antiapoptotic BCL2 and promoted cell survival. Furthermore, DLEU1 upregulation was at least partly facilitated by promoter hypomethylation. In a screen for differentially expressed lncRNAs in ESCC, we determined that DLEU1 was one of the most overexpressed lncRNAs in ESCC tissues and that upregulated DLEU1 expression was associated with a worse prognosis. Yes Functional assays showed that DLEU1 promoted tumor growth by inhibiting cell apoptosis. 35619131 DLEU1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction( miR-320b/PRPS1) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Transwell Assay In our study, the level of DLEU1 in CRC tissues is investigated by qRT-PCR. Our data exhibited that DLEU1 level was observably increased in CRC tissues and CRC cell lines and was closely associated with bad prognosis of CRC patients.Mechanistically, through interacting with miR-320b in CRC, DLEU1 promoted the level of PRPS1 which was a target of miR-320b. The rescue experiment confirmed that knockdown of DLEU1 repressed cell proliferation, migration and invasion while stimulated cell apoptosis via miR-320b/phosphoribosyl pyrophosphate synthetase 1 (PRPS1) axis. In our study, the level of DLEU1 in CRC tissues is investigated by qRT-PCR. Our data exhibited that DLEU1 level was observably increased in CRC tissues and CRC cell lines and was closely associated with bad prognosis of CRC patients. Yes CRC cell proliferation was repressed by sh-LncRNA DLEU1, whereas cell apoptosis was markedly stimulated. Moreover, knockdown of DLEU1 inhibited cell migration and invasion. 34113562 DLEU1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation[DLEU1/miR-133a/IGF-1R axis] qRT-PCR//Luciferase Report Assay//RIP In this study, real-time quantitative polymerase chain reaction (qRT-PCR) in HCC tissues and cell lines revealed that DLEU1 expression was up-regulated, and the increased DLEU1 was closely associated with advanced tumour-node-metastasis stage, vascular metastasis and poor overall survival. Luciferase reporter gene assay and RNA immunoprecipitation (RIP) assay demonstrated that DLEU1 could sponge miR-133a. Moreover, miR-133a inhibition significantly reversed the suppression effects of DLEU1 knockdown on HCC cells. Besides, we found that silenced DLEU1 significantly decreased insulin-like growth factor 1 receptor (IGF-1R) expression (a target of miR-133a) and its downstream signal PI3K/AKT pathway in HCC cells, while miR-133a inhibitor partially reversed this trend. Furthermore, DLEU1 knockdown impaired tumour growth in vivo by regulating miR-133a/IGF-1R axis. Collectively, these findings indicate that DLEU1 promoted HCC progression by sponging miR-133a to regulate IGF-1R expression. Deleted in lymphocytic leukaemia 1/miR-133a/IGF-1R axis may be a novel target for treatment of HCC. In this study, real-time quantitative polymerase chain reaction (qRT-PCR) in HCC tissues and cell lines revealed that DLEU1 expression was up-regulated, and the increased DLEU1 was closely associated with advanced tumour-node-metastasis stage, vascular metastasis and poor overall survival. Yes Function experiments showed that knockdown of DLEU1 significantly inhibited HCC cell proliferation, colony formation, migration and invasion, and suppressed epithelial to mesenchymal transition (EMT) process via increasing the expression of E-cadherin and decreasing the expression of N-cadherin and Vimentin. 31207081 DLEU2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[binding to EZH2] Western Blot//CCK8//qRT-PCR//RIP//Colony Formation Assay//EdU Staining//Transwell Assay DLEU2 was upregulated in HCC tissues.DLEU2 accelerates the proliferative, migratory and invasive abilities of HCC cells via binding to EZH2, thus aggravating the progression of HCC. DLEU2 was upregulated in HCC tissues, especially in those larger than 5 cm in tumor size, accompanied with vascular invasion and in worse tumor stage. Yes Knockdown of DLEU2 attenuated proliferative, migratory and invasive abilities of SMMC7721 and HCLM3 cells.Knockdown of EZH2 attenuated the inhibited proliferation in HCC cells with DLEU2 knockdown. 31376657 DLEU2 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-375-3p/FOXF1 ) CCK8//qRT-PCR//Transwell Assay//Western Blot LINC00022 was highly expressed in CRC tissues compared with paired para-carcinoma tissues (n = 41). Conversely, LINC00022 overexpression showed that opposite effect. We further demonsrtaed that LINC00022 could upregulate FOXF1 expression through sponging miR-375-3p. Moreover, miR-375-3p knockdown reversed the effects of LINC00022 down-regulation. Yes CRC cells with LINC00022 knockdown exhibited decreased cell proliferation, migration, and invasion abilities but increased apoptosis accompanied by decreased protein levels of c-Myc, cyclin D1, cleaved caspase 3, cleaved poly(ADP-ribose) polymerase, matrix metalloproteinase (MMP) 2, and MMP9. Additionally, LINC00022 downregulation in CRC cells suppressed the tube formation of human umbilical vein endothelial cells (HUVECs) as evidenced by decreased vascular endothelial growth factor A levels in LINC00022-silenced cells. The inhibitory effect of LINC00022 knockdown on tumor growth was also observed in an in vivo model. 35468741 DGCR5 LncRNA Homo sapiens Gallbladder Neoplasms GBC tissues and cell lines regulation[MEK/ERK1/2 and JNK/p38 MAPK Pathways] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Here, we found that DGCR5 was upregulated in GBC tissues and cell lines.Taken together, it was uncovered in our study that DGCR5 exerts an oncogenic role by sponging miR-3619-5p and activating MEK/ERK1/2 and JNK/p38 MAPK pathways in GBC progression. Yes Through functional experiments, it was demonstrated that silence of DGCR5 significantly suppressed the cell proliferation, migration, invasion, and induced apoptosis and cell cycle arrest in GBC cells. 32742494 DLEU2 LncRNA Homo sapiens Colorectal Neoplasms 45 pairs of CRC tissues Interaction(CDK6/CDKN1A) CCK8//qRT-PCR//Transwell Assay//Western Blot This study sought to investigate the effects of DLEU2 on CRC pathogenesis, and the underlying mechanism involved. Using a quantitative real-time polymerase chain reaction (qRT-PCR) assay, we demonstrated that the expression levels of DLEU2 in 45 pairs of CRC tissues were higher than those in the corresponding normal colon mucosal tissues. When DLEU2 was silenced using short interfering RNA (siRNA) in CRC cell line, the results demonstrated that DLEU2 silencing suppressed CRC cell tumorigenesis in vitro, which was associated with decreased expression of cyclin dependent kinase 6(CDK6), ZEB1, and ZEB2 as well as enhancing the expression of Cyclin-dependent kinase inhibitor 1A (CDKN1A). In addition, CRC patients with high DLEU2 expression levels exhibited poor overall survival (OS) and recurrence-free survival (RFS), as determined by analyses and measurements from the GEO and GEPIA databases. Yes When DLEU2 was silenced using short interfering RNA (siRNA) in CRC cell line, the results demonstrated that DLEU2 silencing suppressed CRC cell tumorigenesis in vitro, which was associated with decreased expression of cyclin dependent kinase 6(CDK6), ZEB1, and ZEB2 as well as enhancing the expression of Cyclin-dependent kinase inhibitor 1A (CDKN1A). 33391439 DLGAP1-AS2 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(AFF3/ER) RNA Pull-Down//Western Blot//Tunel//Flow Cytometry//qRT-PCR//RIP//Colony Formation Assay Our results showed that DLGAP1-AS2 is significantly upregulated in breast cancer and that tamoxifen can induce DLGAP1-AS2 expression. Mechanistically, DLGAP1-AS2 can bind to the AFF3 protein to inhibit its degradation, which further promotes ER signalling. Yes Further investigation suggested that upregulation of DLGAP1-AS2 can increase cell viability and inhibit apoptosis, while downregulation of DLGAP1-AS2 results in the opposite effects. 35449318 DLGAP1-AS2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC and paired non-tumor tissues from 64 NSCLC patients Interaction(miR-503/cyclin D1) CCK8//qRT-PCR//Colony Formation Assay//Western Blot DLGAP1-AS2 was upregulated in NSCLC and predicted poor survival.Interaction between DLGAP1-AS2 and miR-503 was confirmed by dual luciferase activity assay. Overexpression experiments showed that DLGAP1-AS2 and miR-503 overexpression failed to significantly affect the expression of each other. Interestingly, DLGAP1-AS2 overexpression upregulated cyclin D1, a target of miR-503, increased cell proliferation and reduced the effects of miR-503 overexpression on cyclin D1 expression and cell proliferation. DLGAP1-AS2 was upregulated in NSCLC and predicted poor survival. Yes Overexpression experiments showed that DLGAP1-AS2 and miR-503 overexpression failed to significantly affect the expression of each other. Interestingly, DLGAP1-AS2 overexpression upregulated cyclin D1, a target of miR-503, increased cell proliferation and reduced the effects of miR-503 overexpression on cyclin D1 expression and cell proliferation. 34454450 DLGAP1-AS2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells. Epigenetics(m6A-modified) qRT-PCR//MeRIP//RIP//Western Blot Clinical data showed that DLGAP1-AS2 high-expression was correlated with advanced pathological stage and poor prognosis. Mechanistically, m6A methyltransferase METTL3 enhanced the stability of DLGAP1-AS2 via m6A site binding. Moreover, DLGAP1-AS2 interacted with YTHDF1 to enhance the stability of c-Myc mRNA through DLGAP1-AS2/YTHDF1/m6A/c-Myc mRNA. Clinical data showed that DLGAP1-AS2 high-expression was correlated with advanced pathological stage and poor prognosis. Yes Functionally, DLGAP1-AS2 overexpression promoted the aerobic glycolysis and DLGAP1-AS2 knockdown suppressed the tumor growth of NSCLC cells. 35972892 DLGAP1-AS2 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(CTCF/Myc) MeRIP//qRT-PCR//RIP//Luciferase Report Assay//IHC//ChIP DLGAP1-AS2 was significantly increased in CRC tissues and cell lines. Mechanistically, DLGAP1-AS2 directly bound CTCF, a well-known transcriptional repressor of Myc, resulting in reduced binding of CTCF on Myc promoter and activating Myc transcription. The second hairpin structure of DLGAP1-AS2 was critical for the interaction between DLGAP1-AS2 and CTCF in the nucleus. Yes Knockdown of DLGAP1-AS2 inhibited CRC cell proliferation, migration, invasion in vitro, and tumor growth in vivo. 36222892 DLGAP1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-515-5p/MARK4 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay DLGAP1-AS1 was up-regulated in GC tissues and cell lines, and its high expression was closely associated with larger tumor size, higher TNM stage, and lymph node metastasis. Yes Furthermore, DLGAP1-AS1 overexpression enhanced cell proliferation, migration, and invasion, and miR-515-5p could reverse these effects. DLGAP1-AS1 participated in the regulation of the MARK4 signaling pathway by targeting miR-515-5p. 34037089 DLGAP1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC cells  Interaction(miR-149-5p/TGFB2 axis) CCK8//qRT-PCR//Western Blot These new findings indicate that DLGAP1-AS1 knockdown inhibited the progression of CRC and enhanced the 5-FU sensitivity of CRC cells through miR-149-5p/TGFB2 regulatory axis, suggesting that DLGAP1-AS1 may be a promising therapeutic target for CRC. Yes Functional assays showed that silencing DLGAP1-AS1 expression remarkably inhibited cell proliferation and aggressiveness ability and enhanced apoptosis rate and cell chemosensitivity to 5-FU. 33816780 DLGAP1-AS1 LncRNA Homo sapiens Glioma glioma tissues Interaction( miR-1297/EZH2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay This study seeks to characterize the expression of DLGAP1-AS1 in glioma tissues, which we found to be raised in both glioma samples and cell lines.DLGAP1-AS1 was found to function as a miR-1297 sponge, based on information from luciferase reporter assays, RNA pull-down assays and publicly available online databases. miR-1297 was in turn found to functionally target EZH2. DLGAP1-AS1 modulated EZH2 expressions through miR-1297 sponging. Yes Functional experiments revealed that DLGAP1-AS1 promoted in vitro glioma cell invasion, migration and proliferation. 33901010 DLGAP1-AS1 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(DLGAP1-AS1/miR-628-5p/DDX59 axis) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay The authors observed increased DLGAP1-AS1 expression in glioma tissues and cell lines with higher WHO grades and shorter survival time. The authors identified DLGAP1-AS1 as a molecular sponge of miR-628-5p in glioma cells as the biological functions of DLGAP1-AS1 are partially mediated via miR-628-5p. In addition, DLGAP1-AS1 upregulated DDX59 expression by inhibiting miR-628-5p expression. The authors observed increased DLGAP1-AS1 expression in glioma tissues and cell lines with higher WHO grades and shorter survival time. Yes DLGAP1-AS1 promoted the proliferation, migration, invasion, and EMT of glioma cells, while miR-628-5p counteracted these effects. 35113786 DLGAP1-AS1 LncRNA Homo sapiens Glioblastoma GBM cells Interaction(miR-515-5p/ROCK1/NFE2L1 axis ) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining DLGAP1-AS1 was distinctly upregulated in GBM cells. MiR-515-5p could be sponged by DLGAP1-AS1 in GBM cells and to repress cell proliferation in GBM. Further, Rho-associated coiled-coil containing protein kinase 1 (ROCK1) and Nuclear factor erythroid-2 like 1 (NFE2L1) were confirmed as the target gene of miR-515-5p. Wnt signaling pathway could be activated by DLGAP1-AS1 via regulating ROCK1 and NFE2L1 expression. Yes DLGAP1-AS1 depletion inhibited cell proliferation, but induced apoptosis. 34536977 DLGAP1-AS1 LncRNA Homo sapiens Glioblastoma glioma samples, U87 cell and U251 cell Regulation(ATG4A) CCK8//qRT-PCR//Transfection//Bioinformatics Analysis The results demonstrated that DLGAP1-AS1 was higher in WHO IV glioma than in WHO II and WHO III gliomas, higher in WHO III glioma than in WHO II glioma samples, higher in IDH1 wildtype glioma than in IDH1-mutant glioma samples, and higher in 1p/19q noncodeletion glioma than in 1p/19q codeletion glioma samples. Our conclusion suggested that DLGAP1-AS1 may be a potential prognosis biomarker and facilitated the occurrence and development of glioma via ATG4A in GBM. Moreover, we observed that higher expression levels of DLGAP1-AS1 were correlated to shorter OS time in both low-grade and high-grade gliomas. Yes The data revealed that DLGAP1-AS1 knockdown greatly hindered U87 cell and U251 cell proliferation. 35341001 DLGAP1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cancerous tissues Interaction(microRNA-193a-5p/DTL axis) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//RIP//Flow Cytometry//Luciferase Report Assay//IHC//Bioinformatics Analysis//Transwell Assay The lncRNA DLGAP1-AS1 and denticleless protein homolog (DTL) presented upregulated expression, but microRNA-193a-5p (miR-193a-5p) showed downregulated expression in cancerous tissues of human lung samples from 48 patients with NSCLC. In conclusion, our study highlights a novel regulatory network of the lncRNA DLGAP1-AS1/miR-193a-5p/DTL axis in NSCLC, providing a potential therapeutic strategy for NSCLC. Yes Partial loss of lncRNA DLGAP1-AS1 reduced malignant cell viability, migration, and invasion but induced apoptosis. 36183046 DLG1-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines regulation[ DLG1-AS1/miR-497/YAP1 axis ] RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay The long non-coding RNA (lncRNA), DLG1-AS1, is upregulated in papillary thyroid cancer (PTC) tissues and cell lines. These findings demonstrate that the DLG1-AS1-miR-497-YAP1 axis promotes the growth and metastasis of PTC by forming a ceRNA network. Here, we found that increased expression of DLG1-AS1 caused lymph node metastasis and advanced tumor-node-metastasis (TNM) stage. Yes DLG1-AS1 knockdown inhibited proliferation, invasion, and migration of PTC cells, and impaired tumorigenesis in vivo in mouse xenografts. 33197895 DLG1-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells regulation[Downregulating miR-203] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay We found that DLG1-AS1 was upregulated whereas miR-203 was downregulated in tumor tissues of patients and in TNBC cells compared to the adjacent healthy tissues of patients with TNBC and in normal breast MCF-10A cells, respectively.These results indicate that DLG1-AS1 may promote cancer cell proliferation in TNBC by downregulating the tumor suppressor miR-203. Yes TNBC cell migration was promoted by DLG1-AS1 overexpression and inhibited by miR-203 overexpression or DLG1-AS1 knockdown. 32908786 DLG1-AS1 LncRNA Homo sapiens Thyroid Nodule blood Expression[highly expressed] qRT-PCR In this study, upregulation of DLG1-AS1 distinguished PTC patients from BTN patients and healthy controls Yes In addition, DLG1-AS1 overexpression promoted the proliferation of PTC cells. 31718630 DLEUI LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues ,cell lines regulation[miR-421,ROCK1 ] RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//IF DLEU1 levels were higher in PTC cell lines (BHP5-16, TPC-1,8505C, and SW1736) and patient tissues (n=54) than in a human thyroid follicular epithelial cell line (Nthy-ori3-1) or adjacent normal thyroid tissues.These findings demonstrate that DLEU1 promotes PTC progression by sponging miR-421 and increasing ROCK1 expression. High DLEU1 expression correlated positively with lymph node metastasis and advanced clinical stages in PTC patients. Yes CCK-8, flow cytometry, wound healing, and Transwell invasion assays demonstrated that DLEU1 silencing decreases TPC-1 cell proliferation, survival and progression, but they can be rescued by miR-421 knockdown or ROCK1 overexpression. DLEU1 knockdown in TPC-1 cells decreased in vivo xenograft tumor size and weight compared to controls in nude mice. 32910787 DLEU2 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues Interaction(miR-23b-3p/NOTCH2 axis and Notch signaling pathway) RNA Pull-Down//ChIP//Western Blot//Tunel//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay The expression of long non-coding RNA (lncRNA) DLEU2 was observably high in GC cells and tissues. Moreover, DLEU2 was activated by signal transducer and activator of transcription 1 (STAT1) and sequestered microRNA-23b-3p (miR-23b-3p) to modulate the expression of notch receptor 2 (NOTCH2), thereby stimulating Notch signaling pathway. More importantly, DLEU2 contributed to GC progression via targeting miR-23b-3p/NOTCH2 axis. Yes DLEU2 silence depressed the capacities of proliferation, migration and invasion but promoted apoptosis in GC cells. 33785336 DLEU2 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-30a-5p) IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay DLEU2 was significantly up-regulated in GC tissues and cell lines. The expression of DLEU2 was significantly associated with pathological grading and TNM stage of GC patients. Furthermore, knockdown of DLEU2 inhibited the proliferation, migration, and invasion of AGS and MKN-45 cells, while overexpression of DLEU2 promoted the proliferation, migration, and invasion of HGC-27 cells. MiR-30a-5p could directly bind to the 3' UTR region of ETS2. Moreover, DLEU2 bound to miR-30a-5p through the same binding site, which facilitated the expression of ETS2. Knockdown of DLEU2 reduced the protein level of intracellular ETS2 and inhibited AKT phosphorylation, while overexpression of DLEU2 induced the expression of ETS2 and the phosphorylation of AKT. ETS2 was highly expressed in GC tissues. The expression of ETS2 was significantly associated with age, pathological grading, and TNM stage. ETS2 overexpression promoted cell proliferation and migration of AGS and MKN-45 cells. Furthermore, ETS2 overexpression rescued cell proliferation and migration inhibition induced by DLEU2 down-regulation and miR-30a-5p up-regulation in AGS and MKN-45 cells. The expression of DLEU2 was significantly associated with pathological grading and TNM stage of GC patients. Yes Furthermore, knockdown of DLEU2 inhibited the proliferation, migration, and invasion of AGS and MKN-45 cells, while overexpression of DLEU2 promoted the proliferation, migration, and invasion of HGC-27 cells. 34261460 DLEU2 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(DLEU2/PI3K/Akt axis) CCK8//qRT-PCR//Western Blot//Transwell Assay The expression of DLEU2 was aberrantly up-regulated in GC tissues and cells, which was correlated with the degree of tumor differentiation, cancer antigen 19-9 (CA19-9) and Lauren histologic classification of patients with GC. Mechanistically, the DLEU2/PI3K/Akt axis promoted the progression of GC and the EMT by down-regulating the expression of E-Cadherin and up-regulating those of N-Cadherin and Vimentin. The expression of DLEU2 was aberrantly up-regulated in GC tissues and cells, which was correlated with the degree of tumor differentiation, cancer antigen 19-9 (CA19-9) and Lauren histologic classification of patients with GC. Yes Silencing of DLEU2 induced apoptosis, attenuated viability, migration and invasion as well as inhibited the PI3K/Akt signaling pathway in GC cells. 35736813 DLEU2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation[miR-30c-5p/SOX9 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our studies confirmed that lncRNA DLEU2 was highly expressed in NSCLC tissues and cell lines. lncRNA DLEU2 directly interacted with miR-30c-5p, which further targeted SOX9 and exerted oncogenic functions in NSCLC. Mechanistically, overexpression of lncRNA DLEU2 exhibits tumorigenic effects through downregulating the inhibitory effect of miR-30c-5p on SOX9 expression. In conclusion, Our finding confirmed that lncRNA DLEU2 as a novel oncogenic in NSCLC, which provide a potential novel diagnostic and therapeutic target for NSCLC. Our studies confirmed that lncRNA DLEU2 was highly expressed in NSCLC tissues and cell lines, which was correlated with shorter overall survival in NSCLC patients. Yes In vitro, knockdown of lncRNA DLEU2 inhibited proliferation, invasion, migration and induced apoptosis of both A549 and LLC cells; In vivo, it suppressed tumor growth and metastasis. 31541993 DLEU1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues regulation[miR-429/TFAP2A axis] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay The expression of lncRNA DLEU1 and TFAP2A were upregulated, and miR-429 was downregulated in OC tissues.Silencing of DLEU1 inhibited the proliferation, migration, and invasion of OC cells by regulating miR-429/TFAP2A axis, indicating a potential therapeutic target for OC. Yes Silencing of DLEU1 inhibited the proliferation, migration, and invasion of OC cells. 33170430 DLEU1 LncRNA Homo sapiens Urinary Bladder Neoplasms BLCA tissues Regulation[Regulating the miR-99b/HS3ST3B1 Axis] qRT-PCR//Western Blot Here, we found that DLEU1 was Expression[up-expression]regulated in BLCA tissues and BCA patients with high DLEU1 expression exhibited a shorter survival time.Furthermore, mechanistic analysis and functional assays validated that DLEU1 induced cell proliferation, invasion, and cisplatin resistance of BCA cells by de-repressing the expression of HS3ST3B1 through sponging miR-99b. Low miR-99b and high HS3ST3B1 levels were correlated with worse prognosis in patients with BCA. Here, we found that DLEU1 was Expression[up-expression]regulated in BLCA tissues and BCA patients with high DLEU1 expression exhibited a shorter survival time Yes Ectopic expression of HS3ST3B1 or inhibition of miR-99b reversed DLEU1 knockdown-mediated sExpression[up-expression]pression of cell proliferation, invasion, and cisplatin resistance. 30984249 DLEU1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells Interaction(miR‑149‑5p/CDK6 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Meanwhile, DLEU1 directly bound to miR‑149‑5p, and CDK6 was found to be the direct target of miR‑149‑5p. Furthermore, DLEU1 knockdown‑induced inhibition of OSCC cell proliferation was significantly reversed by the miR‑149‑5p antagomir. Knockdown of lncRNA DLEU1 reversed the proliferation of OSCC cells via regulation of the miR‑149‑5p/CDK6 axis. DLEU1 expression was negatively associated with the survival rate of patients with OSCC. Yes In addition, silencing of DLEU1 notably inhibited the proliferation of OSCC cells by inducing apoptosis. 33880596 DIAPH1-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC cells and tissues Epigenetics(m6A methylation) ChIP//Western Blot//Transfection//Migration Assay//qRT-PCR//Invasion Assay//Transwell Assay Mechanistically, lncRNA DIAPH1-AS1 was identified as a bona fide m6A target of WTAP. WTAP-mediated m6A modification of DIAPH1-AS1 enhanced its stability relying on the m6A reader IGF2BP2-dependent pathway. Furthermore, DIAPH1-AS1 acted as a molecular adaptor that promoted MTDH-LASP1 complex formation and upregulated LASP1 expression, ultimately facilitating NPC growth and metastasis. Yes Furthermore, DIAPH1-AS1 acted as a molecular adaptor that promoted MTDH-LASP1 complex formation and upregulated LASP1 expression, ultimately facilitating NPC growth and metastasis. 34999731 DHRS4-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[ TP53- and TET1-associated DHRS4-AS1/miR-224-3p axis] qRT-PCR//Luciferase Report Assay//Colony Formation Assay//RIP Real-time PCR showed that DHRS4-AS1 was downregulated in cancerous tissues, and bioinformatics analysis revealed that high DHRS4-AS1 expression indicated a good prognosis for NSCLC patients.In conclusion, TP53- and TET1-associated DHRS4-AS1/miR-224-3p axis is an essential mechanism by which NSCLC modulates cancer cell stemness. Real-time PCR showed that DHRS4-AS1 was downregulated in cancerous tissues, and bioinformatics analysis revealed that high DHRS4-AS1 expression indicated a good prognosis for NSCLC patients. Yes DHRS4-AS1 partially reversed the miR-224-3p-decreased TP53 and TET1, resulting in the inhibition of tumor growth in vivo. 33425890 DHRS4-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-522-3p/SOCS5 axis) CCK8//qRT-PCR//BrdU//Western Blot Firstly, it was discovered that DHRS4-AS1 was significantly down-regulated in HCC tissues compared to normal tissues based on the database TCGA. It was also detected in a lower-than-usual expression quantity in HCC tissues we collected and HCC cell lines.Our study subsequently lucubrated that miR-522-3p was a negative target of DHRS4-AS1. Increased expression level of miR-522-3p was examined in HCC tissues and cell lines. Similarly, miR-522-3p mimics could reverse the inhibitory effect on HCC brought by DHRS4-AS1. SOCS5 was then discovered as a down-stream target of miR-522-3p, which suggested that SOCS5 participated in DHRS4-AS1/miR-522-3p axis to collectively mediate the development of HCC. Kaplan-Meier survival analysis revealed that high expression of DHRS4-AS1 contributed to higher overall survival rate of HCC patients. Yes CCK-8, BrdU and colony-forming assays collectively demonstrated that overexpression of DHRS4-AS1 significantly restrained HCC cell proliferation. In vivo xenograft animal experiment showed that DHRS4-AS1 could efficiently preclude the tumor growth of HCC. Further investigation performed using flow cytometry and western blot showed that DHRS4-AS1 exerted its effects by accelerating cell apoptosis and capturing cell cycle in G0/G1 phase. 34666613 DHRS4 LncRNA Homo sapiens Endometriosis EC-ESCs and tissues Interaction(DHRS4-AS1/miR-139-5p/ARRDC3 axis ) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Compared with the EN group, DHRS4-AS1 levels were lower and miR-139-5p levels were higher in EC-ESCs and tissues obtained from patients with endometriosis. Functional assays validated that DHRS4-AS1 targets miR-139-5p, with ARRDC3 being a downstream target of miR-139-5p.Rescue experiments demonstrated that DHRS4-AS1 inhibited EC-ESC proliferation, migration, and invasion, but promoted apoptosis, by targeting miR-139-5p in endometriosis. cleaved-Caspase3 expression level and the cleaved-Caspase 3/Caspase 3 ratio increased, while the expression levels of MMP-9 decreased, after transfection with DHRS4-AS1 overexpression plasmids; however, the effects induced by DHRS4-AS1 overexpression could be partially reversed by co-transfection with the miR-139-5p mimic. Yes Rescue experiments demonstrated that DHRS4-AS1 inhibited EC-ESC proliferation, migration, and invasion, but promoted apoptosis, by targeting miR-139-5p in endometriosis. cleaved-Caspase3 expression level and the cleaved-Caspase 3/Caspase 3 ratio increased, while the expression levels of MMP-9 decreased, after transfection with DHRS4-AS1 overexpression plasmids; however, the effects induced by DHRS4-AS1 overexpression could be partially reversed by co-transfection with the miR-139-5p mimic. 35414313 DGUOK-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cell lines interaction[miR-653-5p] qRT-PCR//RIP We found that DGUOK-AS1 was aberrantly upregulated in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) tissues through TCGA database. Real-time quantitative polymerase chain reaction (RT-qPCR) also verified the high expression of DGUOK-AS1 in CC cell lines. DGUOK-AS1 sequesters miR-653-5p to elevate EMSY in CC. Yes Loss-of-function assays indicated that DGUOK-AS1 silence repressed CC cell growth. 32283566 DGUOK-AS1 LncRNA Homo sapiens cervical squamous cell carcinoma CESC tissues and cells Interaction(miR-499a-5p/ SPRR1B ) Western Blot//Transfection//CCK8//qRT-PCR//RIP//migration assay//Luciferase Report Assay//BrdU DGUOK-AS1 and SPRR1B expressions were obviously elevated, whereas the expression of miR-499a-5p was reduced in both CESC tissues and cells. Notably, DGUOK-AS1 inhibited miR-499a-5p to release SPRR1B, which significantly accelerated the development of CESC. Yes Silencing of DGUOK-AS1 attenuated cell growth and boosted apoptosis of CESC cells. Notably, DGUOK-AS1 inhibited miR-499a-5p to release SPRR1B, which significantly accelerated the development of CESC. 34808501 DGCR5 LncRNA Homo sapiens Stomach Neoplasms blood Interaction[binding to miR-23b] qRT-PCR In this study, we demonstrated that DGCR5 was downregulated in cancerous tissues and plasma samples from patients with GC. In conclusion, our results show that DGCR5 is a tumor-suppressive lncRNA that regulates PTEN and BTG1 expression through directly binding to miR-23b. This mechanism may contribute to a better understanding of GC pathogenesis and provide a potential therapeutic strategy for GC. In this study, we demonstrated that DGCR5 was downregulated in cancerous tissues and plasma samples from patients with GC, and its downregulation was associated with advanced TNM stage and positive lymphatic metastasis. Yes Gain- and loss-of-function of DGCR5 revealed that DGCR5 functioned as a competing endogenous RNA for miR-23b to suppress GC cell proliferation, invasion and migration, and facilitate apoptosis by regulating PTEN and BTG1 in vitro. Furthermore, the overexpression of DGCR5 suppressed tumor growth, and inhibited the expression of miR-23b and proliferation antigen Ki-67, but increased the expression of PTEN and BTG1 in vivo. 30515803 DGCR5 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines Regulation[miR-211-5p/EPHB6 axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay RT-qPCR revealed that DGCR5 expression in NSCLC cells was significantly lower than in normal cell. These findings collectively identified DGCR5/miR-211-5p/EPHB6 triple axis in NSCLC, which may novel understanding regarding the tumorigenesis of NSCLC. Yes DGCR5 overexpression suppresses NSCLC cell growth, migration, and invasion. 31241800 DGCR5 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC clinical samples Interaction(SRSF1) CCK8//qRT-PCR//Western Blot In this study, we found that lncRNA DiGeorge syndrome critical region gene 5 (DGCR5) was upregulated in ESCC clinical samples, which associated with poor prognosis. Mechanistically, DGCR5 could directly bind with SRSF1 to increase its stability and thus stimulate alternative splicing events. Furthermore, we clarified that SRSF1 regulated the aberrant splicing of myeloid cell leukemia-1 (Mcl-1) and initiated a significant Mcl-1L (antiapoptotic) isoform switch, which contributed to the expression of the full length of Mcl-1. In this study, we found that lncRNA DiGeorge syndrome critical region gene 5 (DGCR5) was upregulated in ESCC clinical samples, which associated with poor prognosis. Yes Through RNA interference and overexpression approaches, we confirmed that DGCR5 contributed to promote ESCC cell proliferation, migration, and invasion while inhibited apoptosis in vitro. Moreover, the cell-derived xenograft (CDX) model was validated that DGCR5 could facilitate the tumorigenesis of ESCC in vivo. 34099633 DGCR5 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[miR-21] CCK8//qRT-PCR It was revealed that the expression of DGCR5 was Expression[down-expression]regulated, while microRNA (miR)-21 was Expression[Expression[up-expression]-expression]regulated in CRC. The expression level of DGCR5 in tumor tissue decreased, while expression levels of miR-21 increased, with advancing stages of the disease. miR-21 overexpression increased cancer cell proliferation and attenuated the effects of DGCR5 overexpression. Yes DGCR5 overexpression showed no significant effects on cancer cell migration and invasion, but sExpression[Expression[up-expression]-expression]pressed cancer cell proliferation in vitro. 31452812 DGCR5 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Interaction[sequestering miR-2861] qPCR//PCR//IF In the present study, it was revealed that DGCR5 was significantly downregulated in PTC tissues compared with that in adjacent normal tissues. Taken together, the present results demonstrated that DGCR5 inhibits PTC progression via sponging miR-2861, indicating DGCR5 may serve as a therapeutic target. Yes Through functional experiments, it was demonstrated that ectopic overexpression of DGCR5 markedly suppressed PTC cell growth and invasion. 30651878 DGCR5 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC cells Regulation [EGFR] Western Blot//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay We found that knockdown of LINC00037 resulted in inhibited cell proliferation with activated apoptosis and cell cycle arrest in vitro. LINC00037 could bind to epidermal growth factor receptor (EGFR) and increase the protein level of EGFR. Yes We found that knockdown of LINC00037 resulted in inhibited cell proliferation with activated apoptosis and cell cycle arrest in vitro. Over-expression of LINC00037 in LINC00037 knockdown cells restored and enhanced cell proliferation. In vivo mouse model indicated reduced tumor progression by LINC00037 depletion and promoted tumor progression by LINC00037 overexpression. 29393141 DGCR5 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and HCC cells Regulation[Wnt signaling pathway] qRT-PCR It was indicated that DGCR5 was decreased in HCC tissues and HCC cells including HepG2, Hep3B, MHCC-97L, SNU-449, and SNU-182 cells compared with the normal human liver cell line LO2. Taken these together, it was uncovered in our research that DGCR5 could play tumor suppressive role by targeting Wnt signaling in HCC progression. Yes Overexpression of DGCR5 was able to restrain HCC growth, migration, and invasion capacity in HepG2 and SNU-449 cells. 30230592 DGCR5 LncRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues Interaction[ promotes P21] qRT-PCR Here, we found that DGCR5 expression was significantly downregulated in BCa tissues compared with adjacent normal tissues. In summary, our study demonstrated that DGCR5 transcriptionally promotes P21 expression to suppress BCa progression. Higher expression of DGCR5 predicted higher survival rate in BCa patients. Yes Functional experiments indicated that DGCR5 overexpression markedly inhibited that proliferation, colony formation, and cell-cycle progression in BCa cells. 30238982 DGCR5 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines RegulationWnt signaling pathway] qRT-PCR Here, in our current study, we observed that DGCR5 was downregulated in human cervical cancer cell lines (MS751, SiHa, HeLa, and HT-3) compared with the primary normal cervical squamous cells (NCSC1 and NCSC2). In conclusion, we reported that DGCR5 was involved in cervical cancer progression via modulating the Wnt pathway. Yes Silence of DGCR5 obviously induced cervical cancer cell viability and cell proliferation. Reversely, upregulation of DGCR5 inhibited HeLa and C33A cell survival and proliferation. Furthermore, silencing of DGCR5 increased cervical cancer cell colony formation ability and decreased cell apoptosis, whereas its overexpression exhibited an opposite process. 30552671 DGCR5 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues regulation[Wnt/β-catenin signaling pathway] qRT-PCR//Transwell Assay In this study, DGCR5 expression was obviously higher in TNBC tissues when compared with that in adjacent non-tumor samples.Our study suggests that DGCR5 enhances TNBC cell proliferation and metastasis via inducing Wnt/β-catenin signaling pathway in vitro and in vivo. Yes Cell proliferation, migration and invasion in TNBC were inhibited after knockdown of DGCR5 in vitro. 32521856 DGCR5 LncRNA Homo sapiens Glioma glioma tissues regulation[miR-21/Smad7 and miR-23a/PTEN axes] Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Herein, we identified lncRNA DGCR5 as a downregulated lncRNA in glioma that was negatively regulated by NF-κB1 in an NF-κB1 RE-dependent manner. In conclusion, lncRNA DGCR5 suppresses the capacity of glioma cells to migrate and invade via miR-21/Smad7, whereas it inhibits the proliferation and enhances the apoptosis of glioma cells through miR-23a/PTEN. Yes LncRNA DGCR5 overexpression significantly inhibited the capacity of glioma cells to proliferate, migrate, and invade, whereas promoted the apoptosis of glioma cells. 33085646 DGCR5 LncRNA Homo sapiens Glioblastoma Glioblastoma Tissues Expression[lower expressed] Immunoblotting//Migration Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay LncRNA DGCR5 was down expressed in glioblastoma. Yes Transfection of DGCR5 markedly repressed cell viability and colony formation ability of U87 and U251 cells. Additional, DGCR5 overexpression caused cell cycle arrest and increased cell apoptosis.Moreover, upregulation of DGCR5 suppressed the growth and promoted cell apoptosis of U87 cell in vivo.Finally, overexpression of DGCR5 impaired the migration, invasiveness, and reversed epithelial-to-mesenchymal transition (EMT) process of glioblastoma cell. 31799672 DGCR5 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and LUAD cell lines Interaction(hsa-mir-22-3p) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Bioinformatics Analysis It was observed that DGCR5 was upregulated in LUAD tissues and LUAD cell lines.Both mRNA expression and protein levels of BCL-2 were increased by DGCR5 downregulation while reversely BAX was increased. Additionally, a novel microRNA target of DGCR5, hsa-mir-22-3p was identified through bioinformatics search and confirmed by dual-luciferase reporter system. Gain and loss-of-function studies were performed to verify whether DGCR5 exerts its biological functions through regulating hsa-mir-22-3p in vitro. Overexpression of DGCR5 was able to reverse the tumor inhibitory effect of hsa-mir-22-3p mimics. Downregulated DGCR5 expression was greatly associated with smaller tumor size, implying a favorable prognosis of LUAD patients. Yes Inhibition of DGCR5 can prevent LUAD progression via playing anti-apoptosis roles. Furthermore, in vivo tests tumor xenografts were established to detect the function of DGCR5 in LUAD tumorigenesis. 29030962 DICER1-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC cells Interaction(miR-5586-5p/YTHDF3 ) RNA Pull-Down//MeRIP Bio-information analysis indicated that DICER1-AS1 was downregulated in PC and negatively correlated with glycolytic genes expression. Mechanistically, DICER1-AS1 promoted transcription of its sense gene DICER1 by recruiting transcriptional factor YY1 to the DICER1 promoter. Meanwhile, DICER1 promoted maturation of miR-5586-5p which consequently inhibited glycolytic gene expression including LDHA, HK2, PGK1, and SLC2A1. Notably, enhanced interaction between N6-methyladenosine (m6A) reader YTHDF3 and DICER1-AS1 led to degradation of DICER1-AS1 in response to glucose depletion. Moreover, our data revealed that YTHDF3 was a critical target for miR-5586-5p, by which forming a negative feedback with DICER1-AS1 to regulate glycolysis of PC. Yes Meanwhile, overexpression of DICER1-AS1 inhibited glycolysis, proliferation, and metastasis of PC cells both in vitro and in vivo. 35183226 DICER1-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma cells Regulation[miR-30b/ATG5] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Results showed that lncRNA DICER1-AS1 was up-regulated in osteosarcoma cells using microarray analysis and RT-PCR. In summary, all the results conclude that DICER1-AS1 regulates the proliferation, invasion and autophagy of osteosarcoma via miR-30b/ATG5 axis, providing a novel insight for osteosarcoma tumorigenesis. Yes Cellular functional experiments revealed that DICER1-AS1 knockdown suppressed the proliferation, migration, invasion and autophagy of osteosarcoma cells in vitro. 29772430 DICER1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-296-5p/STAT3 Axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The expressions of DICER1-AS1 and STAT3 mRNA were significantly up-regulated while miR-296-5p expression was remarkably down-regulated in CRC tissues and cell lines.DICER1-AS1 acts as an oncogenic lncRNA in CRC via modulating miR-296-5p/STAT3 axis. Yes Over-expression of DICER1-AS1 or transfection of miR-296-5p inhibitors could promote the proliferation, migration and invasion and inhibit apoptosis of CRC cells, whereas knockdown of DICER1-AS1 or transfection of miR-296-5p mimics had the opposite effects. 33116860 DLEU1 LncRNA Homo sapiens Premature Ovarian Failure 7 POF and control ovary tissues Interaction( MiR-146b-5p) qRT-PCR//Transfection//RNA Pull-Down//Cell Apoptosis Assay Increased DLEU1 expression and decreased miR-146b-5p expression were observed in POF.DLEU1 directly interacted with MiR-146b-5p and was expressed in both nuclear and cytoplasm samples of KGN cells. Yes In KGN cells, DLEU1 and miR-146b-5p failed to regulate the expression of each other. However, DLEU1 promoted cell apoptosis and reduced the inhibitory effects of miR-146b-5p on cell apoptosis. 34740384 DLEU1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck oral squamous cell carcinoma (OSCC) cells Regulation( JAK-STAT signaling) qRT-PCR//ChIP//Western Blot We previously reported that DLEU1 (deleted in lymphocytic leukemia 1) is one of the lncRNAs overexpressed in oral squamous cell carcinoma (OSCC) cells, where it exhibits oncogenic activity. Chromatin immunoprecipitation-sequencing (ChIP-seq) analysis revealed that DLEU1 knockdown induced significant changes in the levels of histone H3 lysine 4 trimethylation (H3K4me3) and H3K27 acetylation (H3K27ac) in OSCC cells. Notably, DLEU1 knockdown suppressed levels of H3K4me3/ H3K27ac and expression of a number of interferon-stimulated genes (ISGs), including IFIT1, IFI6 and OAS1, while ectopic DLEU1 expression activated these genes. Western blot analysis and reporter assays suggested that DLEU1 upregulates ISGs through activation of JAK-STAT signaling in OSCC cells. Yes Notably, DLEU1 knockdown suppressed levels of H3K4me3/ H3K27ac and expression of a number of interferon-stimulated genes (ISGs), including IFIT1, IFI6 and OAS1, while ectopic DLEU1 expression activated these genes. Moreover, IFITM1, one of the ISGs induced by DLUE1, was frequently overexpressed in primary OSCC tumors, and its knockdown inhibited OSCC cell proliferation, migration and invasion. 34650128 DLEU1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells Interaction(miR-126-5p/GAB1 axis) qRT-PCR//MTT//Western Blot Our results indicated that DLEU1 and GAB1 were upregulated, while miR-126-5p was downregulated in OSCC cells. DLEU1 mediated biological effects in OSCC through binding to miR-126-5p, which directly targeted GAB1. miR-126-5p knockdown rescued the inhibitory function of DLEU1 depletion on proliferation, migration and invasion. Meanwhile, the miR-126-5p mimic exerted suppressive functions in the progression of OSCC, which were neutralized after GAB1 overexpression. Yes Silencing DLEU1 reduced OSCC cell proliferation, migration, and invasion, while DLEU1 overexpression had the opposite effects. 36039933 DLEU1 LncRNA Homo sapiens Endometrial Neoplasms interaction[mTOR] qRT-PCR//RIP//Western Blot In order to focus on the role and mechanism of lncRNA DLEU1 in endometrial carcinoma, we used qRT-PCR to detect the expression of lncRNA DLEU1 and found that lncRNA DLEU1 was highly expressed in endometrial carcinoma compared to normal endometrium.RiP confirmed that lncRNA DLEU1 could bind to mTOR. Yes In addition, up-regulation of lncRNA DLEU1 promoted cell viability, migration, invasion, and reduced the proportion of apoptosis. Otherwise, down-regulation of lncRNA DLEU1 produced opposite results. Xenograft nude mice model assay showed that lncRNA DLEU1 can promote tumorigenesis in vivo. 29745433 DLEU1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissue, cell line Regulation[regulating the miR-671-5p/DDX5 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our results showed that DLEU1 was highly expressed in osteosarcoma tissue specimens and cells. In conclusion, DLEU1 acted as an oncogene in osteosarcoma by directly sponging miR-671-5p and regulating the expression of DDX5. Yes Downregulation of DLEU1 in osteosarcoma cells inhibited the cell proliferation, migration and invasion. 31379208 DLEU1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissue Regulation[miR-381/CXCR4 axis] qRT-PCR Our studies indicated that the DLEU1 expression level was upregulated in PDAC tissue samples compared with adjacent normal tissue.Bioinformatics analysis predicted that miR-381 potentially targeted the DLEU1 3'-untranslated region (UTR), suggesting an interaction between miR-381 and DLEU1. Furthermore, miR-381 also targeted the chemokine receptor-4 (CXCR4) messenger RNA 3'-UTR, which was validated by luciferase reporter assay. Taken together, our study demonstrated the oncogenic role of DLEU1 in clinical PDAC specimens and cellular experiments, showing the potential involvement of DLEU1/miR-381/CXCR4 pathway. These results provide novel insight into PDAC tumorigenesis. Moreover, the aberrant overexpression of DLEU1 indicated poor prognosis of patients with PDAC. Yes Loss-of-function experiments revealed that DLEU1 knockdown inhibited the proliferation, migration, and invasion of PDAC cells in vitro and decreased tumor growth in vivo. 30382579 DLEU1 LncRNA Homo sapiens Glioblastoma Interaction[SP1-DLEU1-miR-4429 ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//ChIP We found that DLEU1 was up-regulated in GBM and DLEU1 knockdown significantly inhibited GBM cell proliferation and induced apoptosis. As predicted by bioinformatics analysis and validated in mechanistic assays, SP1 could bind to the promoter region of DLEU1 to activate DLEU1 transcription. Additionally, miR-4429 was verified as a target gene of DLEU1 and negatively modulated by DLEU1. More importantly, miR-4429 overexpression repressed the mRNA and protein levels of SP1 via binding to the 3'UTR of SP1. Overexpression of SP1 or miR-4429 inhibitor could partly abolish the effect of DLEU1 knockdown on cell viability and apoptosis in GBM. Accordingly, our experimental data revealed that SP1-DLEU1-miR-4429 formed a feedback loop to promote GBM development, providing a new evidence for the role of DLEU1 in GBM. Yes We found that DLEU1 was up-regulated in GBM and DLEU1 knockdown significantly inhibited GBM cell proliferation and induced apoptosis. 31713587 DLEU1 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cells Interaction(miR-149-5p/YAP1/TEAD2/SOX2 axis) Cell Proliferation Assay//qRT-PCR//In Vivo Experiment//Western Blot In this study, TCGA data analysis showed upregulation of DLEU1 expression in CCA. Furthermore, we confirmed that DLEU1 expression was increased in CCA tissues and cells compared with corresponding controls. Mechanistically, DLEU1 expression was transcriptionally facilitated by transcription factor YY1. Moreover, DLEU1 promoted oncogene YAP1 expression by functioning as a sponge to competitively bind to miR-149-5p. YAP1 promoted CCA proliferation, invasion and stemness maintenance, whereas miR-149-5p inhibited malignant biological behavior of CCA. Rescue experiments confirmed that the cancer-promoting effect of DLEU1 was saved by interfering miR-149-5p or YAP1. Furthermore, YAP1 promoted tumor stemness maintenance partly by acting as a transcriptional coactivator to promote TEAD2-induced SOX2 expression. Upregulated DLEU1 was related to poor clinicopathological characteristics. Yes Functionally, silencing DLEU1 inhibited CCA proliferation, invasion, stemness maintenance and chemo-resistance, whereas amplifying DLEU1 promoted malignant biological behavior of CCA cells. 35864972 DLEU1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and cells interaction[miR-490 ] qRT-PCR DLEU1 was upregulated in EC tissues and cells. Our findings indicate that DLEU1 contributes to EC development by sponging miR-490 to regulate SP1 expression. Yes Suppression of DLEU1 significantly inhibited Ishikawa cell viability, promoted cell apoptosis, decreased BCL-2 expression and increased the expression of Bax, cleaved-caspase-3 and cleaved-caspase-3, suppressed cell migration and invasion, and inhibited EMT via increasing the expression of E-cadherin and decreasing the expression of N-cadherin, Snail and Vimentin. 30001771 DKFZp434J0226 LncRNA Homo sapiens pancreatic ductal adenocarcinoma clinical specimens Interaction(SF3B6) In Vivo Experiment//RNA Pull-Down//Western Blot//Co-IP//Migration Assay//qRT-PCR//RIP//Microarray//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//IF Clinical analyses revealed that overexpression of DKFZp434J0226 was associated with worse tumor grading, frequent perineural invasion, advanced tumor-node-metastasis stage, and decreased overall survival and time to progression. Mechanistically, DKFZp434J0226 interacted with the splicing factor SF3B6 and promoted its phosphorylation, which further regulated the alternative splicing of pre-mRNA. Clinical analyses revealed that overexpression of DKFZp434J0226 was associated with worse tumor grading, frequent perineural invasion, advanced tumor-node-metastasis stage, and decreased overall survival and time to progression. Yes Functional assays demonstrated that DKFZp434J0226 promoted PDAC cell migration, invasion, and growth in vitro and accelerated tumor proliferation in vivo. 34470609 DICER-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction(microRNA-650/CSR1 ) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay DICER-AS1 and CSR1 expression levels were significantly decreased in gastric cancer tissues compared with normal tissues, and qPCR analysis showed that miR-650 was upregulated in gastric cancer tissues. Bioinformatic analysis and dual luciferase reporter assays revealed that DICER-AS1 functioned as a competing endogenous RNA that sponged miR-650, which in turn regulated CSR1 expression. Yes . Importantly, ectopic DICER-AS1 and CSR1 expression inhibited cell proliferation and migration in vitro and suppressed xenograft tumorgenicity in vivo. 34586953 DIRC1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Regulation[AKT/mTOR signaling] CCK8//qRT-PCR//Western Blot//Transwell Assay The results showed that high expression of DIRC1 was found in GC tissues compared with normal gastric tissues.Mechanically, the activity of AKT/mTOR signaling was suppressed by the knockdown of DIRC1. High expression of DIRC1 was associated with more cases of severer tumor malignancy and shorter OS; besides, high-level of DIRC1 was suggested to be an independent prognostic factor for GC. Yes Furthermore, the knockdown of DIRC1 inhibited SGC-7901 GC cells proliferation, migration and invasion. 30575946 DIRC1 LncRNA Homo sapiens gastric adenocarcinoma macrophages, dendritic cells, and Th1 cells Regulation qRT-PCR//RNA-seq//Bioinformatics Analysis Increased DIRC1 expression in STAD was associated with T stage (P = .004), race (P = .045), histologic grade (P = .029) and anatomic neoplasm subdivision (P = .034). Increased DIRC1 expression in STAD was associated with T stage (P = .004), race (P = .045), histologic grade (P = .029) and anatomic neoplasm subdivision (P = .034). Yes DIRC1 is related to epidermis, collagen-containing extracellular matrix, receptor-ligand activity, protein digestion and absorption, etc. 36401393 DIO3OS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Regulation(hnRNPK-MYC-CDC25A axis) RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis//ChIP DIO3OS is downregulated in NSCLC, and its low expression is related to poor prognosis. DIO3OS competitively bound heterogeneous nuclear ribonucleoprotein K (hnRNPK), repressed the binding of hnRNPK to MYC DNA and MYC mRNA, reduced the promoting roles of hnRNPK on MYC transcription and translation, led to the repression of MYC transcription and translation, and therefore remarkably decreased the expression of MYC and CDC25A, a downstream target of MYC. DIO3OS is downregulated in NSCLC, and its low expression is related to poor prognosis. Yes Ectopic expression of DIO3OS repressed NSCLC cell growth and motility and promoted NSCLC cell apoptosis in vitro. DIO3OS also repressed NSCLC tumorigenesis and metastasis in vivo. 34761103 DIO3OS LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[microRNA-328/Hhip Axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay DIO3OS was lower in HCC tissues and cells, while upregulation of DIO3OS repressed malignant biological behavior both in vitro and in vivo. All in all, the obtained data suggested that DIO3OS interacted with Hhip-dependent Hh signaling pathway to inhibit HCC progression through binding to miR-328, which may be a potent therapeutic target for HCC. Yes DIO3OS was lower in HCC tissues and cells, while upregulation of DIO3OS repressed malignant biological behavior both in vitro and in vivo. 32547226 DIO3OS LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissue samples and cells regulation[ DIO3OS/let-7d/NF-κB2 axis] Wound Healing Assay//Immunoblotting//CCK8//qRT-PCR//Luciferase Report Assay//ELISA//IHC//Transwell Assay DIO3OS showed to be considerably increased within thyroid cancer tissue samples and cells. In conclusion, DIO3OS/let-7d/NF-κB2 axis regulates the viability, DNA synthesis capacity, invasion, and migration of thyroid cancer cells. Yes Knocking down DIO3OS within thyroid carcinoma cells suppressed cancer cell viability, the capacity of DNA synthesis, cell invasion, as well as cell migration; besides, proliferating markers, ki-67 and PCNA, were decreased by DIO3OS knockdown. 33058043 DIO3OS LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and PC cell lines Interaction[upregulating ALDOA] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Our results showed that DIO3OS was highly expressed in human PC tissues and PC cell lines. Through online predictive tools and functional experiments, we found that DIO3OS could bind directly to microRNA-122 (miR-122) and inhibited its expression, which functioned as a tumor suppressor in PC cells. We also verified that ALDOA was the direct target of miR-122, and the tumor suppressive effects caused by DIO3OS knockdown or miR-122 overexpression could be rescued by re-expression of ALDOA in PC cells. Yes DIO3OS exhibited oncogenic properties in stimulating PC cell proliferation and invasion in vitro and promoting cancer growth in vivo. 31384177 DINOL LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction[modulating p21 and Bax] qRT-PCR It was manifested that DINO was significantly downregulated in GC tissues. Taken these, DINO might exert a tumor inhibitory role in the progression of GC through modulating p21 and Bax. Yes Moreover, it was displayed that GC cell proliferation was suppressed by DINO overexpression, whereas silencing DINO increased cell proliferation significantly. 30775800 CBR3-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-29a) qRT-PCR//RNA Pull-Down//Transwell Assay CBR3-AS1 was downregulated, and miR-29a was upregulated in CRC. CBR3-AS1 and miR-29a directly interacted with each other. CBR3-AS1 was localized in both nucleus and cytoplasm fractions. CBR3-AS1 is downregulated in CRC and inhibits miR-29a-mediated cell migration and invasion by sponging miR-29a. Yes CBR3-AS1 overexpression failed to alter miR-29a expression but reduced its enhancing effects on cell invasion and migration. 35107754 CBR3-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues regulation[ miR-136-5p/Smad3 axis] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//IHC PlncRNA-1 was found to be overexpressed in 71.43% of bladder cancer tissues. Moreover, the expression level correlated with tumor invasion, T stage, age, and number of tumors, but not with gender, recurrent status, preoperative treatment, pathological grade, and tumor size. Yes Inhibiting PlncRNA-1 expression impaired the proliferation, migration, and invasion of T24 and 5637 bladder cancer cells in vitro and in vivo. 33288752 circRAB31 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and gastric cancer cell lines Interaction(miR-885-5p) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Wound Healing Assay//Invasion Assay//Tunel//Migration Assay//CCK8//Flow Cytometry//FISH//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining circRAB31 was downregulated in gastric cancer tissues and gastric cancer cell lines compared with normal tissues and a human gastric epithelial cell line (GES-1). Yes Overexpression of circRAB31 suppressed gastric cancer proliferation and metastasis in vitro and in vivo, whereas silencing of circRAB31 had the opposite effects. Bioinformatic analysis as well as pull-down and luciferase assays revealed that circRAB31 exerted tumor-suppressive functions by binding directly to miR-885-5p. 34901392 AFAP1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung blood Regulation[ IRF7 and the RIG-I-like receptor signaling pathway] Flow Cytometry//qRT-PCR//MTT//EdU Staining//Transwell Assay A high expression of AFAP1-AS1 was identified in NSCLC, alongside with a reduced level of IL-12 and increased levels of IL-10 and interferon (IFN)-γ.lncRNA AFAP1-AS1 promotes migration and invasion of non-small cell lung cancer via up-regulating IRF7 and the RIG-I-like receptor signaling pathway. Aberrant expressions of AFAP1-AS1 were associated with pathological grade, TNM staging and metastatic potential of NSCLC. Yes Over-expression of AFAP1-AS1 promoted NSCLC cell proliferation, invasion and migration while inhibiting cell apoptosis. 30278439 AFAP1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Expression[highly expressed] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay It was found that AFAP1-AS1 expression was upregulated in NSCLC tissues and cells. Yes Knockdown of AFAP1-AS1 and overexpression of miR-139-5p inhibited NSCLC cell proliferation, colony formation and chemotherapy resistance and increased cell apoptosis. 31696057 AFAP1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells regulation[miR-498/VEGFA Axis] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expression levels of lncRNA AFAP1-AS1 and VEGFA mRNA were upregulated, but miR-498 was downregulated in ESCC tissues and cells.Downregulation of AFAP1-AS1 impeded the proliferation and migration and induced apoptosis of ESCC cells by regulating miR-498/VEGFA axis, which might serve as a novel biomarker for the diagnosis and treatment of ESCC. Yes Functionally, AFAP1-AS1 silencing inhibited the proliferation and migration and induced apoptosis of ESCC cells. 32801880 AFAP1-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer clinical tissues Interaction(SNIP1/c-Myc) RNA Pull-Down//Western Blot//ISH//Wound Healing Assay//FISH//qRT-PCR//H&E Staining//IP//Transwell Assay AFAP1-AS1 was highly expressed in lung cancer clinical tissues and its expression was positively correlated with lung cancer patients' poor prognosis.AFAP1-AS1 promoted lung cancer cells migration and invasion through interacting with Smad nuclear interacting protein 1 (named SNIP1), which inhibited ubiquitination and degradation of c-Myc protein. AFAP1-AS1 was highly expressed in lung cancer clinical tissues and its expression was positively correlated with lung cancer patients' poor prognosis.In vivo experiments confirmed that AFAP1-AS1 could promote lung cancer metastasis. Yes In vivo experiments confirmed that AFAP1-AS1 could promote lung cancer metastasis. 34168109 AFAP1-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cells Interaction(miR-545-3p/HDGF axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//migration assay//Invasion Assay The expression levels of AFAP1-AS1 and HDGF were increased, while miR-545-3p was decreased in lung cancer tissues and cells. Furthermore, AFAP1-AS1 mediated cell progression through regulating miR-545-3p expression. In addition, miR-545-3p negatively regulated the expression level of HDGF via binding 3'-untranslated region of HDGF. As expected, AFAP1-AS1 knockdown inhibited lung cancer progression via affecting miR-545-3p/HDGF axis. Yes AFAP1-AS1 knockdown suppressed lung cancer cell proliferation, migration, and invasion and induced apoptosis. 33290312 AFAP1-AS1 LncRNA Homo sapiens Colorectal Neoplasms blood Interaction[LncRNA GAS8-AS ] CCK8//qRT-PCR LncRNA AFAP1-AS1 was upregulated in CRC patients and was inversely correlated with GAS8-AS1 only in CRC patients but not in healthy controls.GAS8-AS1 overexpression mediated the downregulation of AFAP1-AS1 in colon cancer cells, while AFAP1-AS1 overexpression did not significantly affect GAS8-AS1 expression. Expression level of GAS8-AS1 decreased, while expression level of AFAP1-AS1 increased with the increase of primary tumor diameters. Yes GAS8-AS1 overexpression led to inhibited, while AFAP1-AS1 overexpression led to promoted proliferation of CRC cells, and AFAP1-AS1 overexpression reduced the inhibitory effects of GAS8-AS1 overexpression on cancer cell proliferation. 31132513 AFAP1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-195-5p and WISP1) Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay AFAP1-AS1 and WISP1 expressions were notably increased, and miR-195-5p expression was markedly reduced in CRC. The dual-luciferase assay verified that AFAP1-AS1 could bind to miR-195-5p. miR-195-5p could target and regulate WISP1 expression. Overexpression of WISP1 or miR-195-5p inhibition reversed the inhibition effect of AFAP1-AS1 knockdown on the biological activity of CRC cells. Yes AFAP1-AS1 knockdown could inhibit the malignant behavior of CRC cells. 34335760 AFAP1-AS1 LncRNA Homo sapiens Colonic Neoplasms CC tissues Expression[highly expressed] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay We analyzed the lncRNA expression patterns in Gene Expression Omnibus (GEO) datasets and the Cancer Genome Atlas (TCGA) RNA-seq datasets, and found that the expression level of AFAP1-AS1 was significantly elevated in CC tissues. High levels of AFAP1-AS1 were associated with poor disease-free survival and overall survival in CC patients. Yes In vitro experiments demonstrated that AFAP1-AS1 knockdown significantly inhibited the cell invasive and migration capability in CC cell line HT-29. 30588252 AFAP1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular tumorous tissues,cell line Expression[highly expressed] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay AFAP1-AS1 was upregulated in surgical tumorous tissues from hepatocarcinoma patients compared with the paired paracancerous non-tumor liver tissues, and in hepatocarcinoma Huh7, HCCLM3 and HepG2 cell lines compared with LO2, a normal liver cell line. Yes AFAP1-AS1 knockdown noticeably suppressed the proliferative, migratory and invasive properties, and the epithelial-mesenchymal transition (EMT) process of HepG2 and HCCLM3 through upregulating E-cadherin and downregulating N-cadherin and vimentin. 32280542 AFAP1-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC cells and tissues Interaction(miR-107/PDK4 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The present study revealed that AFAP1-AS1 expression was elevated in OC cells and tissues. AFAP1-AS1 functioned as a sponge of miR-107, and miR-107 reversed the effects of AFAP1-AS1 on OC cells. It was validated that miR-107 was able to bind to PDK4, and AFAP1-AS1 regulated PDK4 expression by competitively binding with miR-107. AFAP1-AS1 expression and FIGO stage were positively correlated. Yes AFAP1-AS1 knockdown repressed OC cell proliferation, migration and invasion. 33926489 AFAP1-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues,cell Expression[highly expressed] CCK8//qRT-PCR//EdU Staining//Transwell Assay No matter in BCa tissues or in cell samples, compared to the corresponding normal controls, AFAP1-AS1 was found highly expressed; at the same time, in invasive bladder cancer tissues, the expression level of AFAP1-AS1 was also higher than that in non-invasive tissues. Meanwhile, survival analysis revealed that patients with BCa with high expression of AFAP1-AS1 owned a shorter overall survival rate than those with low expression, indicating a negative interplay between AFAP1-AS1 expression and patients' prognosis. Yes In addition, in BCa cell lines, according to the results of CCK-8, EDU, and transwell assays, the proliferative capacity, as well as the invasive ability of BCa cells, were found weakened after downregulation of AFAP1-AS1. 32964963 AFAP1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues,cell lines Regulation[up-regulated] CCK8//qRT-PCR//Western Blot The expression of AFAP1-AS1 was higher in the OSCC tissues than in the NOK cells, and the relative expression of AFAP1-AS1 was higher in the SCC25 cells than in the NOK cells (P<0.001). AFAP1-AS1 expression was associated with the degree of diffe-rentiation, TNM stage, lymphatic metastasis, and poor prognosis of OSCC (P<0.05). Patients with a high expression of AFAP1-AS1 had lower survival rates than those with a low expression of AFAP1-AS1 (P<0.05). Yes The inhibition of AFAP1-AS1 expression consequently suppressed the proliferation, invasion, and migration of SCC25. 31875436 AFAP1-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues regulation[miR-545-3p/VEGFA pathway] qRT-PCR Herein, we found the high expression of AFAP1-AS1 in human EC tissues, and AFAP1-AS1 was correlated with EC patients' prognosis and clinical features. We further showed that AFAP-AS1 could promote the expression of VEGFA through the adsorption of miR-545-3p, thus promoting the angiogenesis and invasion of EC, and contribute to tumor growth and metastasis in vivo. Herein, we found the high expression of AFAP1-AS1 in human EC tissues, and AFAP1-AS1 was correlated with EC patients' prognosis and clinical features. Yes AFAP-AS1 could affect EC cell proliferation, migration, and invasion, and contributed to endothelial cell angiogenesis. 32504788 AFAP1-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Regulation[RhoC/ROCK1/p38MAPK/Twist1 signaling pathway] qRT-PCR//Western Blot AFAP1-AS1 expression is upregulated in human OS tissues and cell lines.AFAP1-AS1 knockdown elicits a signaling inhibition including decreased levels of RhoC, ROCK1, p38MAPK and Twist1. Moreover, AFAP1-AS1 interacts with RhoC. Overexpression of RhoC can partly reverse AFAP1-AS1 downregulation-induced cell EMT inhibition. Yes AFAP1-AS1 knockdown induces OS cell apoptosis and cell cycle G0/G1 arrest, suppresses OS cells growth, migration, invasion, vasculogenic mimicry formation and epithelial-mesenchymal transition (EMT), and affects actin filament integrity. AFAP1-AS1 knockdown suppresses OS tumor formation and growth in nude mice. 31443665 AFAP1-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines regulation[ miR-497/IGF1R axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay In this study, quantitative real time polymerase chain reaction (qRT-PCR) revealed that AFAP1-AS1 was upregulated in OS tissues and cell lines. Taken together, these findings indicate that AFAP1-AS1 promotes OS progression by regulating miR-497/IGF1R axis, providing a therapeutic target for OS. Increased AFAP1-AS1 was associated with poor prognosis. Yes Loss-of-function experiments demonstrated that knockdown of AFAP1-AS1 inhibited the proliferation, colony formation, migration, invasion and induced cell apoptosis. 32509208 AFAP1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms Expression[highly expressed] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Cell Cycle Assay//Transwell Assay In the present study, we found that AFAP1‑AS1 was elevated and hypomethylated in cervical cancer and was associated with a poor prognosis of patients with cervical cancer by analyzing the Cancer RNA‑Seq Nexus (CRN), MethCH and UCSC XENA databases. Yes Wound healing experiments and matrigel invasion experiments revealed that the downregulation of AFAP1‑AS1 suppressed the migration and invasion of cervical cancer cells. 30816545 AFAP1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CD44v6(+) CC cells Interaction(miR-27b-3p/VEGF-C axis) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Microarray//Cell Cycle Assay CD44v6(+) CC cells had remarkable stemness and a high level of AFAP1-AS1. In the mechanism study, miR-27b-3p/VEGF-C signaling was demonstrated to be a key downstream of AFAP1-AS1 in the CD44v6(+) CC cells. Yes However, AFAP1-AS1 knockdown with siAFAP1-AS1 suppressed the cell cycle transition of G(1)/S phase and inhibited self-renewal of CD44v6(+) CC cells, the levels of the stemness markers octamer-binding transcription factor 4 (OCT4), osteopontin (OPN), and cluster of differentiation 133 (CD133), and the epithelial-mesenchymal transition (EMT)-related proteins Twist1, matrix metalloprotease (MMP)-9, and VEGF-C. 34334630 AFAP1-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Regulation[Wnt/β-Catenin Signaling Pathway ] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay We found that AFAP1-AS1 was overexpressed in TNBC tissues and cells.Our results also revealed that upregulation of AFAP1-AS1 activated Wnt/β-catenin pathway to promote tumorigenesis and cell invasion by increasing the expression of C-myc and epithelial-mesenchymal transition-related molecules in TNBC. Overexpression of LncRNA AFAP1-AS1 was associated with poor prognosis in TNBC patients. Yes Moreover, we demonstrated that upregulation of AFAP1-AS1 promoted cell proliferation and invasion, and inhibited cell apoptosis in vitro, while overexpression of AFAP1-AS1 promoted tumor growth in vivo. 30505272 AFAP1-AS1 LncRNA Homo sapiens Glioma glioma tissues Expression[highly expressed] qRT-PCR AFAP1-AS1 was upregulated in the glioma tissues compared with that in the control tissues, and the expression level was correlated with glioma grading and KPS scores. Yes After knockdown of AFAP1-AS1, the invasion capacities of the glioma cells declined significantly, and the expressions of invasion-related proteins MMP2 and MMP9 also decreased significantly. 30178845 AFAP1-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues interaction[binds to KAT2B] RNA Pull-Down//qRT-PCR//RIP//Luciferase Report Assay//ChIP AFAP1-AS1 is upregulated in NPC and is a poor prognostic indicator for survival in NPC patients. Mechanistic investigations suggested that AFAP1-AS1 binds to KAT2B and promotes acetyltransferase activation at two residues (E570/D610). KAT2B further promotes H3K14 acetylation and protein binding to the bromo domain of TIF1α. Consequently, TIF1α acts as a nuclear transcriptional coactivator of RBM3 transcription, leading to YAP mRNA stabilization and enhanced NPC tumorigenicity. AFAP1-AS1 is upregulated in NPC and is a poor prognostic indicator for survival in NPC patients. Yes AFAP1-AS1 was required for NPC proliferation in vitro and tumorigenicity in vivo. 33330099 AFAP1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[p21 ] qRT-PCR//RIP//ChIP AFAP1-AS1 expression was increased in NSCLC tissues and was correlated with clinical outcomes of NSCLC.Mechanistic investigations found that AFAP1-AS1 could interact with EZH2 and recruit EZH2 to the promoter regions of p21, thus epigenetically repressing p21 expression. Yes Further experiments revealed that inhibition of its expression in NSCLC cells resulted in diminished cell growth in vitro and in vivo. 29793547 AFAP1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Regulation[AFAP1 ] qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay In this study, we conducted global lncRNA profiling and identified that AFAP1-AS1 is significantly upregulated in NSCLC, suggesting that AFAP1-AS1 may be important for lung cancer development.Mechanistically, AFAP1-AS1 functions through positively regulating the expression of AFAP1 protein. Yes Through gain- and loss-of-function studies, AFAP1-AS1 was demonstrated to promote cell migration and invasion. 30293090 AFAP1-AS1 LncRNA Homo sapiens Thyroid Neoplasms TC tissues and cells Interaction(miR-204-3p/DUSP4 axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay Highly expressed AFAP1-AS1 was in association with advanced TNM stage and positive lymph node metastasis. MiR-204-3p was targetedly repressed by AFAP1-AS1, and miR-204-3p could negatively regulate DUSP4 expression. AFAP1-AS1 augmented the expression of DUSP4 via repressing miR-204-3p, and the effects of AFAP1-AS1 overexpression on thyroid cancer cells were also partly abolished by miR-204-3p restoration. Highly expressed AFAP1-AS1 was in association with advanced TNM stage and positive lymph node metastasis. Yes Knockdown of AFAP1-AS1 suppressed the proliferation, migration and invasion of thyroid cancer cells, and overexpression of AFAP1-AS1 induced a reversed effect. 34652441 AFAP1-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(miR-497-5p) In Vivo Experiment//Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay AFAP1-AS1 was upregulated in breast cancer tissues and cells, and AFAP1-AS1 knockdown could hinder proliferation and migration of breast cancer cells, and contribute to cell apoptosis. MiR-497-5p, which was downregulated in breast cancer, was verified to be a target of AFAP1-AS1 and inversely correlated with AFAP1-AS1 expression. SEPT2, as a target gene of miR-497-5p, was negatively regulated by miR-497-5p and positively correlated with AFAP1-AS1 expression. Importantly, AFAP1-AS1 could upregulate SEPT2 expression by sponging miR-497-5p, and modulate cell progression by regulation of the miR-497-5p/SEPT2 axis in breast cancer. Yes AFAP1-AS1 was upregulated in breast cancer tissues and cells, and AFAP1-AS1 knockdown could hinder proliferation and migration of breast cancer cells, and contribute to cell apoptosis. 32955920 AGAP2-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues interaction[binding to miRNA-425-5p] Western Blot//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay We found that AGAP2-AS1 expression was significantly higher in human PTC tissues than adjacent noncancerous tissues (n=110; p<0.01) and correlated with lymph node metastasis (p=0.01) and tumor-node-metastasis stage (p=0.006). These results demonstrate that AGAP2-AS1 expression is significantly elevated in PTC tissues and that, by binding to miRNA-425-5p, it upregulates the MMP2 expression, thereby increasing the invasiveness and migration capacity of PTC cells. We found that AGAP2-AS1 expression was significantly higher in human PTC tissues than adjacent noncancerous tissues (n=110; p<0.01) and correlated with lymph node metastasis (p=0.01) and tumor-node-metastasis stage (p=0.006). Yes AGAP2-AS1 downregulation decreased migration and invasion by PTC cells, and reduced expression of matrix metalloproteinase-2 (MMP2). 32960785 AGAP2-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues Interaction[suppressing ANKRD1 and ANGPTL4] ChIP//Flow Cytometry//qRT-PCR//RIP//MTT//Colony Formation Assay//EdU Staining//Transwell Assay Increased expression of AGAP2-AS1 was associated with tumor size and pathological stage progression in patients with PC.Furthermore, AGAP2-AS1 epigenetically inhibited the expression of ANKRD1 and ANGPTL4 by recruiting zeste homolog 2 (EZH2), thereby promoting PC proliferation and metastasis. In summary, our data show that RREB1-induced upregulation of AGAP2-AS1 regulates cell proliferation and migration in PC partly through suppressing ANKRD1 and ANGPTL4 by recruiting EZH2. AGAP2-AS1 represents a potential target for the diagnosis and treatment of PC in the future. Increased expression of AGAP2-AS1 was associated with tumor size and pathological stage progression in patients with PC. Yes AGAP2-AS1 affected proliferation, apoptosis, cycle arrest, invasion, and metastasis of PC cells in vitro, and AGAP2-AS1 regulated PC proliferation in vivo. 30814490 AGAP2-AS1 LncRNA Homo sapiens Cholangiocarcinoma 32 intrahepatic tumor tissues Expression [highly expressed] Western Blot//qPCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//IHC//ChIP AGAP2-AS1 was significantly upregulated in CCA tumor tissues. SP1 induced AGAP2-AS1 plays an important role in tumorigenesis. Yes AGAP2-AS1 knockdown significantly inhibited proliferation and caused apoptosis in CCA cells. 33522895 AGAP2-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cell lines Interaction(miR-193a-3p/LOXL4 axis) cell invasion assay//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay Our results showed that AGAP2-AS1 expression was remarkably increased in human LSCC tissues and cell lines. In addition, AGAP2-AS1 sponged miR-193a-3p and regulated its expression in LSCC cells. Inhibition of miR-193a-3p reversed the effects of AGAP2-AS1 knockdown on LSCC cells. Furthermore, Lysyl oxidase-like 4 (LOXL4) was a target gene of miR-193a-3p and the role of miR-193a-3p was mediated by LOXL4. Yes Knockdown of AGAP2-AS1 significantly inhibited the proliferation and invasion of LSCC cells. 35113007 AGAP2-AS1 LncRNA Homo sapiens Prostatic Neoplasms Prostate cancer tissues regulation[AGAP2-AS1/miR-195-5p/PDLIM5] RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//IHC//Transwell Assay LncRNA AGAP2-AS1 was found to be highly expressed in prostate cancer.Taken together, the key findings of our study demonstrated that lncRNA AGAP2-AS1 silencing exerted suppressive effects on the development of prostate cancer via the miR-195-5p-dependent downregulation of PDLIM5. Yes Silencing of lncRNA AGAP2-AS1 contributed to the suppression of proliferation, migration and invasion of cancer cells in vitro. 33101368 AGAP2-AS1 LncRNA Homo sapiens Prostatic Neoplasms PCa cells Interaction(miR-628-5p/FOXP2 feedback loop) In Vivo Experiment//Western Blot//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay AGAP2-AS1 was confirmed to be highly expressed in PCa cells. According to mechanism assays, AGAP2-AS1 sponged miR-628-5p, which was found to restrain PCa cell growth. Besides, FOXP2 was identified as a target gene of miR-628-5p, and its expression was negatively regulated by miR-628-5p and positively modulated by AGAP2-AS1. Yes Functionally, AGAP2-AS1 silencing inhibited cell proliferation, migration, invasion and epithelial–mesenchymal transition process and induced apoptosis. 34255057 AGAP2-AS1 LncRNA Homo sapiens ovarian carcinoma tumors and adjacent healthy tissues Interaction[ lncRNA MEG3] qRT-PCR Compared with adjacent healthy tissues, AGAP2-AS1 was significantly upregulated in tumor tissues.lncRNA AGAP2-AS1 is upregulated in ovarian carcinoma and negatively regulates lncRNA MEG3 to participate in the regulation of cancer cell proliferation. Yes AGAP2-AS1 overexpression led to downregulation of MEG3, while MEG3 overexpression failed to affect AGAP2-AS1. AGAP2-AS1 overexpression promoted proliferation of OC cells, while MEG3 overexpression inhibited proliferation of OC cells. 31233485 AGAP2-AS1 LncRNA Homo sapiens Melanoma melanoma tissues and cells Interaction(IGF2BP2/SLC7A11) CCK8//qRT-PCR//Flow Cytometry//Western Blot In the current study, the findings revealed that AGAP2-AS1 was considerably greater in melanoma than in healthy tissues and that the level of AGAP2-AS1 in cancer tissue was significantly linked to the cancerous TNM stage of patients. The mechanistic results suggest AGAP2-AS1 increases SLC7A11 mRNA stability through the IGF2BP2 pathway. In the current study, the findings revealed that AGAP2-AS1 was considerably greater in melanoma than in healthy tissues and that the level of AGAP2-AS1 in cancer tissue was significantly linked to the cancerous TNM stage of patients. Individuals with high AGAP2-AS1 had a considerably shorter survival duration than patients with low AGAP2-AS1, regardless of progression-free survival or overall survival. Yes Functionally, downregulating the expression of AGAP2-AS1 can inhibit the growth of melanocytes. Compared with the control group, AGAP2-AS1 knockdown increased Erastin-mediated iron death in melanoma cells. However, iron death inhibitor FERSINT-1 restored this effect, while Erastin induced melanoma cell death. Besides, intracellular iron and Fe2+ levels increased after AGAP2-AS1 knockdown in melanoma cells treated with Erastin compared with the si-NC group. In addition, AGAP2-AS1 silencing resulted in a significant decrease in glutathione (GSH) content in Erastin-treated melanoma cells. 35707044 AGAP2-AS1 LncRNA Homo sapiens Coronary Artery Disease EV recipient cells Regulation(VEGFA-dependent mechanism) qRT-PCR A human lncRNA array revealed that certain EV-lncRNAs are significantly dysregulated in CAD patients. Circulating small EVs (sEVs) from patients with (n = 30) or without (n = 30) CAD were used to quantify PUNISHER (also known as AGAP2-antisense RNA 1 [AS1]), GAS5, MALAT1, and H19 RNA levels. PUNISHER (p = 0.002) and GAS5 (p = 0.02) were significantly increased in patients with CAD, compared to non-CAD patients. Fluorescent labeling and quantitative real-time PCR of sEVs demonstrated that functional PUNISHER was transported into the recipient cells. Mechanistically, the RNA-binding protein, heterogeneous nuclear ribonucleoprotein K (hnRNPK), interacts with PUNISHER, regulating its loading into sEVs. Knockdown of PUNISHER abrogated the EV-mediated effects on endothelial cell (EC) migration, proliferation, tube formation, and sprouting. Angiogenesis-related gene profiling showed that the expression of vascular endothelial growth factor A (VEGFA) RNA was significantly increased in EV recipient cells. Protein stability and RNA immunoprecipitation indicated that the PUNISHER-hnRNPK axis regulates the stability and binding of VEGFA mRNA to hnRNPK. Loss of PUNISHER in EVs abolished the EV-mediated promotion of VEGFA gene and protein expression. Intercellular transfer of EV-incorporated PUNISHER promotes a pro-angiogenic phenotype via a VEGFA-dependent mechanism. Yes Knockdown of PUNISHER abrogated the EV-mediated effects on endothelial cell (EC) migration, proliferation, tube formation, and sprouting. 34484864 AGAP2-AS1 LncRNA Homo sapiens Psoriasis skin tissue of psoriasis patients Interaction(miR-424-5p/AKT3 axis) Western Blot//Transfection//MeRIP//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay We found that AGAP2-AS1 level was upregulated in the skin tissue of psoriasis patients than that of healthy controls and AGAP2-AS1 could promote proliferation and inhibit apoptosis of keratinocytes. Methyltransferase like 3(METTL3)-mediated m6A modification suppressed the expression of AGAP2-AS1 via YTHDF2-dependent AGAP2-AS1 stability. Thus, downregulation of METTL3 resulted in the upregulation of AGAP2-AS1 in psoriasis. AGAP2-AS1 functioned as a competitive endogenous RNA by sponging miR-424-5p to upregulate AKT3, activate AKT/mTOR pathway, as well as promote cell proliferation in keratinocytes. Yes We found that AGAP2-AS1 level was upregulated in the skin tissue of psoriasis patients than that of healthy controls and AGAP2-AS1 could promote proliferation and inhibit apoptosis of keratinocytes. 34930676 AGAP2-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines Interaction(MiR-628-5p) Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay Our results showed that AGAP2-AS1 was significantly upregulated in PTC tissues. MiR-628-5p was found to act as a target miRNA of AGAP2-AS1 in PTC. The expression level of miR-628-5p in PTC tissues was negatively associated with that of AGAP2-AS1. Yes Knockdown of AGAP2-AS1 inhibited the proliferation, migration and invasion of PTC cells. In vivo experiment showed that AGAP2-AS1 knockdown inhibited the tumorigenesis of PTC. 33604734 AFAP-AS1 LncRNA Homo sapiens Thyroid Carcinoma, Anaplastic cell lines Interaction(miR-155-5p/ ETS1/ERK pathway) In Vivo Experiment//IHC//Western Blot//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay Firstly, we showed that relative RNA expression of AFAP-AS1 in ATC cells was higher than in immortalized thyroid cells. miR-155-5p was negatively regulated by AFAP-AS1. Moreover, AFAP-AS1 regulated ETS1/ERK pathway by sponging miR-155-5p. Yes Next, AFAP-AS1 was verified as an oncogene in ATC since knock-down of AFAP-AS1 inhibited cell proliferation and accelerated apoptosis. Finally, we confirmed knock-down of AFAP-AS1 significantly suppressed tumor proliferation in vivo. 33999777 AFAP1-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Expression[highly expressed] Flow Cytometry//qRT-PCR//Wound Healing Assay//MTT The results indicated that AFAP1-AS1 expression levels were significantly increased in GC tissues and cell lines compared with the corresponding noncancerous tissues and normal gastric cells. In addition, the patients with GC with increased AFAP1-AS1 expression exhibited an advanced clinical stage and an association with the occurrence of lymph node metastasis compared with those with decreased AFAP1-AS1 expression. Yes In vitro assays demonstrated that knockdown of AFAP1-AS1 decreased levels of cell proliferation and migration. 31452798 AFAP1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissue and cell lines regulation[miR-155-5p/FGF7 Axis] qPCR//RIP//PCR//IP//IF AFAP1-AS1 was upregulated in GC tissues and cell lines and was closely correlated with poor prognosis of GC patients.AFAP1-AS1 might be an oncogenic lncRNA that promoted GC progression by acting as a competing endogenous RNA (ceRNA) that regulates the expression of FGF7 through sponging miR-155-5p, suggesting that AFAP1-AS1 may be a novel potential therapeutic target for GC. AFAP1-AS1 was upregulated in GC tissues and cell lines and was closely correlated with poor prognosis of GC patients. Yes AFAP1-AS1 knockdown inhibited proliferation, migration, and invasion of GC cells, indicating that AFAP1-AS1 acts as an oncogene in GC. 32051698 AFAP1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[KLF2] qRT-PCR//ChIP//Western Blot AFAP1-AS1 was upregulated in GC tissues, and its expression in lymph node metastasis and progressive gastric cancer tissues were much higher. LncRNA AFAP1-AS1 accelerates the proliferative and migratory abilities of GC cells by downregulating the expression of KLF2, thus promoting the progression of GC. AFAP1-AS1 was upregulated in GC tissues, and its expression in lymph node metastasis and progressive gastric cancer tissues were much higher. Yes Knockdown of AFAP1-AS1 reduced the viability, proliferative and migratory abilities, but induced apoptosis of GC cells. 32016968 AFAP1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tumor tissues and also GC cell lines Interaction(miR-205-5p/AFAP1) Western Blot//EdU Staining//Migration Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Microarray//Colony Formation Assay//Invasion Assay qPCR results showed that AFAP1-AS1 was significantly overexpressed in GC tumor tissues and also GC cell lines, comparing to their paired non-GC tissues. Mechanical analysis suggested that AFAP1-AS1 is involved in regulation of its maternal gene, AFAP1, at both mRNA level and protein level. Luciferase reporter gene assay indicated that lncRNA AFAP1-AS1, as a ceRNA, is able to sponge miR-205-5p. Moreover, miR-205-5p has been well demonstrated to participate in the regulation of AFAP1 expression and the phenotypes of GC cells, including proliferation, migration and invasion. Furthermore, statistical analysis revealed that the overexpression of AFAP1-AS1 was significantly correlated with tumor size (p=0.018) and grade of differentiation (p=0.042). Yes Subsequently, artificially decreasing the expression of AFAP1-AS1 with its specific siRNA dramatically inhibited the proliferation, migration and invasion of GC cell lines (SGC-7901 and BGC-823 cells). 34234560 AFAP1-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissue,cell lines (MCF-7, SK-RB-3, MDA-MB-231and MDA-MB-468) Expression[highly expressed] qRT-PCR//Wound Healing Assay The expression of AFAP1-AS1 was up-regulated in human breast cancer tissue and associated with malignancy status, high expression of AFAP1-AS1 had a poor prognosis in breast cancer patients. The expression of AFAP1-AS1 was up-regulated in human breast cancer tissue and associated with malignancy status, high expression of AFAP1-AS1 had a poor prognosis in breast cancer patients. Yes AFAP1-AS1 knockdown can inhibit the proliferation, metastasis and promote apoptosis of MCF-7. 29974352 AFAP1-AS1 LncRNA Homo sapiens Breast Neoplasms TNBC tissues Interaction(miR-2110/Sp1 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Expression of the lncRNA actin filament-associated protein 1 antisense RNA1 (AFAP1-AS1) has been found to be significantly higher in TNBC than in other subtypes or in normal tissue samples. Mechanistically, the dual-LRA highlighted that miR-2110 was an inhibitory target of AFAP1-AS1, and that AFAP1-AS1 functioned as a miR-2110 sponge to increase Sp1 expression. Yes We found that silencing AFAP1-AS1 and Sp1 or upregulating miR-2110 suppressed the proliferation, migration, and invasion of MDA-MB-231 and MDA-MB-468 cells in vitro as well as tumor growth in vivo. 34145213 AFAP1-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma nasopharyngeal carcinoma tissues and cells Interaction(miR-497-5p/CELF1 pathway) Western Blot//Transfection//Wound Healing Assay//qPCR//CCK8//RIP//Luciferase Report Assay//Transwell Assay//ChIP In current study, AFAP1-AS1 was found to be up-regulated in nasopharyngeal carcinoma tissues and cells. The interaction between AFAP1-AS1 and miR-497-5p was confirmed. AFAP1-AS1 was demonstrated to regulate CELF1, a target gene of miR-497-5p. Further functional analysis revealed that AFAP1-AS1 knockdown attenuated SP1-induced nasopharyngeal carcinoma progression. Yes AFAP1-AS1 overexpression and knockdown were conducted in nasopharyngeal carcinoma cells. The results proved that AFAP1-AS1 promoted the survival and migration of nasopharyngeal carcinoma cells. Additionally, specificity protein 1 (SP1) was enhanced in nasopharyngeal carcinoma tissues and cells, and induced AFAP1-AS1 expression. 33400247 AFAP1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[AFAP1-AS1/LSD1/HBP1 axis] qRT-PCR//RIP//ChIP Here we reported that AFAP1-AS1, recruiting and binding to lysine-specific demethylase 1 (LSD1), was generally overexpressed in human non-small-cell lung cancer (NSCLC) tissues using quantitative real-time PCR. In conclusion, our results indicate that AFAP1-AS1 is carcinogenic and that the AFAP1-AS1/LSD1/HBP1 axis could constitute a new therapeutic direction for NSCLC. Higher AFAP1-AS1 expression was significantly correlated with larger tumor size (P = .008), lymph node metastasis (P = .025), higher TNM stage (P = .024), and worse overall survival in NSCLC patients. Yes In vitro experiments revealed that AFAP1-AS1 downregulation inhibited cell migration and induced apoptosis; AFAP1-AS1 knockdown also hindered tumorigenesis in vivo. 31069893 ADAMTS9-AS1 LncRNA Homo sapiens Glioma glioma tissues and cells Regulation(Wnt1, β-catenin, c-myc and PCNA) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Invasion Assay//Transwell Assay Using quantitative real-time PCR analysis, we found that ADAMTS9-AS1 was upregulated in glioma tissues and cells in comparison to corresponding controls. Furthermore, we demonstrated that knockdown of ADAMTS9-AS1 suppressed Wnt1, β-catenin, c-myc and PCNA, while upregulating E-cadherin expression. . ADAMTS9-AS1 expression level was correlated to tumor size (p=0.005) and WHO grade (p=0.002). Kaplan-Meier analysis and Cox multivariate analysis showed that ADAMTS9-AS1 could serve as an independent prognostic factor affecting the overall survival of glioma patients. Yes Functionally, depletion of ADAMTS9-AS1 significantly suppressed the proliferation, migration and invasion in glioma cell lines (U251 and U87), as shown via CCK-8 assay, Edu corporation assay, wound healing assay and transwell assay. 34923953 ADORA2A-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(FSCN1/AKT Axis) RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Invasion Assay ADORA2A-AS1 was identified as an HCC-related lncRNA, whose low expression was correlated with advanced stage and poor outcome in HCC.Mechanistically, ADORA2A-AS1 competitively bound HuR (Hu Antigen R), repressed the binding of HuR to FSCN1 transcript, decreased FSCN1 transcript stability, and downregulated FSCN1 expression. The expression of FSCN1 was negatively correlated with ADORA2A-AS1 in HCC tissues. Through downregulating FSCN1, ADORA2A-AS1 repressed AKT pathway activation. Functional rescue assays showed that blocking of FSCN1/AKT axis abrogated the roles of ADORA2A-AS1 in HCC. ADORA2A-AS1 was identified as an HCC-related lncRNA, whose low expression was correlated with advanced stage and poor outcome in HCC. Yes Gain- and loss-of functional experiments demonstrated that ADORA2A-AS1 inhibited HCC cell proliferation, induced cell apoptosis, repressed cell migration and invasion, and repressed xenograft growth and metastasis in vivo. 34733789 ADIRF-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-761/IRS1 axis.) CCK8//qRT-PCR ADIRF-AS1 was found to be overexpressed in OS, and the overall survival of patients with OS who had high ADIRF-AS1 levels was shorter than that of those with low levels. Mechanistically, ADIRF-AS1 acted as a competitive endogenous RNA for microRNA-761 (miR-761) that siphoned miR-761 away from its target, namely insulin receptor substrate 1 (IRS1), leading to IRS1 overexpression. Rescue experiments showed that low levels of miR-761 or restoration of IRS1 could neutralize the effects of ADIRF-AS1 ablation in OS cells. ADIRF-AS1 was found to be overexpressed in OS, and the overall survival of patients with OS who had high ADIRF-AS1 levels was shorter than that of those with low levels. Yes ADIRF-AS1 knockdown led to restricted proliferation, migration, and invasiveness of OS cells and increased apoptosis. Additionally, ADIRF-AS1 downregulation impeded tumor growth in vivo. 35030964 ADIRF-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cells Interaction(PBAF) qRT-PCR//RNA Pull-Down//Luciferase Report Assay ADIRF-AS1 expression correlates with survival in human ccRCC, particularly in PBRM1 wild-type, but not mutant, tumors. Our findings suggest that ADIRF-AS1 functions partly through PBAF to regulate specific genes as a BMAL1-CLOCK-regulated, oncogenic lncRNA. Yes Loss of ADIRF-AS1 eliminates in vivo tumorigenesis, partially rescued by concurrent loss of PBRM1 only when co-injected with Matrigel, suggesting a PBRM1-independent function of ADIRF-AS1. 36261012 ADIPOQ LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and Caco-2 cells regulation[miR-219c-3p/TP53 pathway] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results suggested that the expression of ADIPOQ and TP53 was downregulated in human colorectal cancer tissues and Caco-2 cells. For the first time, we found that lncRNA-ADIPOQ was downregulated in human colorectal cancer cells, which could facilitate tumor proliferation, migration and invasion as a ceRNA by sponging with miR-219c-3p. Yes qRT-PCR and CCK-8 assay showed that ADIPOQ expression is correlated with the proliferation of colorectal cancer cells. Transwell assay showed that ADIPOQ regulated the migration ability of colorectal cancer cells. 32744690 ADAMTS9-AS2 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cells Interaction(miR-223-3p and TGFBR3) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Microarray//Cell Cycle Assay//Invasion Assay//Transwell Assay qRT-PCR results demonstrated that lncADAMTS9-AS2 was lowly expressed in lung cancer tissues. In vivo assay found that ADAMTS9-AS2 suppressed the lung tumor growth. Bioinformatics predicted that miR-223-3p bound directly to the ADAMTS9-AS2 and TGFBR3, which was later confirmed by luciferase reporter system. ADAMTS9-AS2 transfection increased TGFBR3 mRNA and protein expressions in lung cancer cells, but miR-223-3p transfection significantly decreased them. Besides, our results showed that miR-223-3p induced cellular apoptosis while TGFBR3 group showed the complete opposite effect. It was proved that ADAMTS9-AS2 and TGFBR3 were the direct genes of miR-223-3p. MiR-223-3p promotes proliferation, migration and invasion of lung cancer cells by targeting TGFBR3. Yes High expression of ADAMTS9-AS2 in lung cancer cells significantly reduced proliferation ability and inhibited migration, as well as elevating their apoptosis rate. 29707897 ADAMTS9-AS2 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Expression[lower expressed] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay ADAMTS9-AS2 was down-regulated in CRC patients according to the gene microarray analysis, which was confirmed in CRC tissues and cells. High expression of ADAMTS9-AS2 was associated with a higher 5-year RFS rate (83.8% vs 73.5%, P=0.041) and it was an independent prognostic factor for RFS [hazard ratio (HR)=0.528; 95% CI 0.299 to 0.932; P=0.028] at the early stage of CRC. Yes ADAMTS9-AS2 overexpression in CRC cells inhibited cell proliferation, migration, and invasion, while suppression of ADAMTS9-AS2 showed opposite effects. 31413211 ADAMTS9-AS2 LncRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues and cells Interaction[CDH3 ] qRT-PCR//RNA Pull-Down//RIP//ChIP Esophageal cancers expressed low levels of ADAMTS9-AS2 and high levels of CDH3.Overexpressed ADAMTS9-AS2 aids in the suppression of esophageal cancer development, which is achieved via inducing CDH3 promoter methylation. Yes Furthermore, proliferation, invasion, and migration of esophageal cancer cells were inhibited by ADAMTS9-AS2 via downregulation of CDH3. Suppressed esophageal cancer development in vivo was also detected after ADAMTS9-AS2 overexpression. 31621118 ADAMTS9-AS2 LncRNA Homo sapiens Esophageal Neoplasms EC tissue and cells Interaction(miR-196b-5p/PPP1R12B ) qRT-PCR//Western Blot ADAMTS9-AS2 was significantly lowly expressed while miR-196b-5p was increased in EC tissue and cells. ADAMTS9-AS2 bound to miR-196b-5p and constrained its expression. Overexpressed ADAMTS9-AS2 inhibited EC cell malignant progression via downregulating miR-196b-5p, while overexpressed miR-196b-5p reversed this inhibitory effect. ADAMTS9-AS2 modulated PPP1R12B level by competitively inhibiting miR-196b-5p. PPP1R12B played a modulatory role in EC by inhibiting cell cycle pathway. Overexpressed ADAMTS9-AS2 regulated the tumor-forming ability of EC cells in vivo through miR-196b-5p/PPP1R12B/cell cycle signaling pathway axis. ADAMTS9-AS2 downregulated PPP1R12B by adsorbing miR-196b-5p, so as to regulate the cell cycle signaling pathway to inhibit EC malignant progression. Yes Overexpressed ADAMTS9-AS2 inhibited EC cell malignant progression via downregulating miR-196b-5p, while overexpressed miR-196b-5p reversed this inhibitory effect. ADAMTS9-AS2 modulated PPP1R12B level by competitively inhibiting miR-196b-5p. PPP1R12B played a modulatory role in EC by inhibiting cell cycle pathway. 35503407 ADAMTS9-AS2 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tumor samples Regulation(RPL22/ TGF-β signaling) In Vivo Experiment//RNA Pull-Down//Western Blot//Bioinformatics Analysis//Transfection//Wound Healing Assay//Invasion Assay//Migration Assay//CCK8//qRT-PCR//Microarray//Colony Formation Assay//EdU Staining The expression of ADAMTS9-AS2 was decreased in TNBC tumor samples (P < 0.05), with such downregulation being correlated with TNM stage, age, and tumor size. From a mechanistic perspective, ADAMTS9-AS2 was found to control the expression of RPL22 and to thereby modulate TGF-β signaling to control TNBC progression. The expression ofADAMTS9-AS2 was decreased in TNBC tumor samples (P < 0.05), with such downregulation being correlated with TNM stage, age, and tumor size. Yes Overexpressing ADAMTS9-AS2 promoted the apoptotic death and cell cycle arrest of tumor cells in vitro and inhibited tumor growth in vivo. 34178640 ADAMTS9-AS2 LncRNA Homo sapiens Carcinoma, Adenoid Cystic cells Regulation[PI3K/Akt and MEK/Erk Signaling] RNA Pull-Down//Western Blot//ISH//qRT-PCR//Luciferase Report Assay//ChIP In our study, we found that ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9) antisense RNA 2 (ADAMTS9-AS2) was significantly upregulated in SACC patients with metastasis and SACC-lung metastasis (LM) cells.Overexpression of ADAMTS9-AS2 competitively bound to miR-143-3p that inhibited ITGA6 from miRNA-mediated degradation, and thus it activated the activity of PI3K/Akt and MEK/Erk signaling and facilitated SACC metastasis. Moreover, ADAMTS9-AS2 expression was closely associated with the prognosis and distant metastasis in SACC patients. Yes Knockdown of ADAMTS9-AS2 significantly inhibited migration and invasion of SACC cells in vitro and distant lung metastasis in vivo. 30217729 ADAMTS9-AS2 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues Regulation[miR-600/EZH2 axis] Western Blot//ISH//qRT-PCR//RIP//Luciferase Report Assay Our results indicate that the lncRNA ADAMTS9-AS2 is most significantly upregulated in TSCC tissues from patients with lymph node metastasis and is closely associated with poor prognosis. In summary, our results demonstrate an explicit oncogenic role of ADAMTS9-AS2 in TSCC tumorigenesis via competition with miR-600, suggesting a new regulatory mechanism of ADAMTS9-AS2 and providing a potential therapeutic target for TSCC patients. Yes Furthermore, ADAMTS9-AS2 knockdown in TSCC cells leads to a inhibition of cell migration and invasion and reverses TGF-β1 induced EMT. ADAMTS9-AS2 knockdown also inhibits TSCC cell growth in vitro and in vivo. 30970517 ADAMTS9-AS2 LncRNA Homo sapiens Liver Neoplasms liver cancer cell Regulation Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay The results suggested that ADAMTS9-AS2 downregulated the phosphorylation of AKT and mTOR, the protein expression level of PIK3CB, as well as the expression levels of autophagy protein SQSTM1 and antiapoptotic protein Bcl-2. Yes The results demonstrated that ADAMTS9-AS2 inhibited liver cancer cell proliferation, migration and invasion. Finally, the effect of ADAMTS9 on PI3K/AKT/mTOR signaling pathway-associated proteins [AKT, phosphorylated-AKT, phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit β (PIK3CB), mTOR and phosphorylated-mTOR], several key autophagy-related proteins [light chain 3-I/II (LC3-I/II), beclin 1 (BECN1) and sequestosome 1 (SQSTM1)] and apoptosis-related proteins (Bax and Bcl-2) was detected via western blotting. 33850531 ADAMTS9-AS2 LncRNA Homo sapiens Oral Submucous Fibrosis OSCC tissues regulation[AKT signalling pathway] Western Blot//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay lncRNA ADAMTS9-AS2 is down-regulated in OSCC tissues compared with OSF and normal mucous tissues. Through profiling miRNA expression profile regulated by exosomal ADAMTS9-AS2, significantly enriched pathways include metabolic pathway, PI3K-Akt signalling pathway and pathways in cancer, indicating that exosomal ADAMTS9-AS2 exerts its functions through interacting with miRNAs during OSF progression. Low ADAMTS9-AS2 expression is associated with poor overall survival. Yes Functional studies reveal that exosomal ADAMTS9-AS2 suppresses OSCC cell growth, migration and invasion in vitro. 33345447 ADAMTS9-AS2 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder tumor cells regulation[PI3K/AKT/mTOR signal pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay First, ADAMTS9-AS2 downregulation in bladder tumor cells was identified.Third, ADAMTS9-AS2 was linked with PI3K/AKT/mTOR pathway related-molecules, several key autophagy, and apoptotic proteins. Yes Second, ADAMTS9-AS2 contributed to the inhibition of proliferation, migration, and invasion in bladder tumor cells. 32801743 ADAMTS9-AS2 LncRNA Mus musculus Ischemic Stroke MCAO mice Interaction(miR-185-5p/IGFBP-2 Axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Transfection//qRT-PCR//RIP//Luciferase Report Assay//IF The results showed that ADAMTS9-AS2 was decreased in the plasma of acute ischemic stroke (AIS) patients and in the brain tissue and plasma of MCAO mice, and the low expression of ADAMTS9-AS2 was associated with the increase in infarct size.Molecular mechanism results indicated that ADAMTS9-AS2 and miR-185-5p affected the pathological process of ischemic stroke through ceRNA mechanism, and IGFBP-2 was a downstream target gene of miR-185-5p. These findings demonstrated that ADAMTS9-AS2 promoted angiogenesis through regulating miR-185-5p/IGFBP-2 axis, suggesting that ADAMTS9-AS2 may be a potential marker for the diagnosis and treatment of neurological diseases. Yes Besides, compared with the control group, MCAO treatment slightly promoted angiogenesis, which was enhanced by the overexpression of ADAMTS9-AS2. 35098480 ADAMTS9-AS1-202 LncRNA Homo sapiens Mouth Neoplasms oral cancer tissues Expression[lower expressed] qRT-PCR LncRNAs were aberrantly expressed in oral cancer tissues. The expression levels of ENST00000470447.1 and ENST00000412353.1 in oral cancer tissues were significantly lower than those in matched adjacent noncancerous tissues (P < .001). Furthermore, ENST00000470447.1 expression was significantly correlated with tumor differentiation (P = .030). Cox regression analyses demonstrated that high ENST00000470447.1 expression was associated with better disease-free survival for patients with oral cancer (hazard ratio: 0.25, 95% CI: 0.06-0.95; P = .041). Yes in vitro assays indicated that overexpression of ENST00000470447.1 significantly inhibited the proliferation, migration, and invasion ability of Tca-8113 cells, whereas promoted the apoptosis of Tca-8113 cells. 30969450 ADAMTS9-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction( miR-301b-3p/TGFBR2/JAK STAT pathway) Luciferase Report Assay//Transwell Assay//EdU Staining//Western Blot Markedly inactivated ADAMTS9-AS1 in breast cancer pertained to patient's prognosis. MiR-301b-3p was capable of binding TGFBR2/ADAMTS9-AS1. However, overexpression of ADAMTS9-AS1 stimulated miR-301b-3p binding ADAMTS9-AS1 and repressed miR-301b-3p binding TGFBR2 mRNA. ADAMTS9-AS1 could sequester miR-301b-3p to inhibit progression of breast cancer via TGFBR2/JAK STAT pathway. Markedly inactivated ADAMTS9-AS1 in breast cancer pertained to patient's prognosis. Yes ADAMTS9-AS1 interference enhanced cancer proliferation and invasion, facilitated levels of KI67, PCNA, MMP-9 and MMP-2, and activated the JAK STAT signaling pathway. While silencing miR-301b-3p reversed the effect of ADAMTS9-AS1 interference. 34900984 ADAMTS9-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Expression[highly expressed] CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay Our data showed that ADAMTS9-AS1 expression level was significantly up-regulated in CRC tissues and cell lines compared with corresponding controls. High ADAMTS9-AS1 level was associated with TNM stage, lymph node invasion and worse survival prognosis. Yes Depletion of ADAMTS9-AS1 significantly suppressed cell proliferation, G1/S transition, migration and invasion, as well as suppressed CDK4/Cyclin D1 and epithelial-mesenchymal transition (EMT). 32918700 ADAMTS9-AS1 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC cells Interaction( miR-587/SLC7A11 axis ) CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting results showed that ADAMTS9-AS1 expression was elevated in EOC cells; microRNA-587 expression was up-regulated and SLC7A11 expression was down-regulated after knocking down ADAMTS9-AS1 by transfection with siRNAs; however, microRNA-587 inhibitor reversed SLC7A11 expression in ADAMTS9-AS1 knocking down cells. Additionally, micoRNA-587 inhibitor reversed the effect of ADAMTS9-AS1 silence on the ferroptosis and cell function. Moreover, dual-luciferase reporter gene assay and RNA immunoprecipitation assay confirmed that miR-587 was as a sponge for ADAMTS9-AS1 and SLC7A11. Yes Ferroptosis related marker detection and cell function assay confirmed that knocking down ADAMTS9-AS1 inhibited EOC cells proliferation and migration by promoting ferroptosis. Overexpression of micoRNA-587 also promoted ferroptosis while inhibited cells proliferation and migration in EOC cells. 35311457 ADORA2A-AS1 LncRNA Homo sapiens Leukemia, Myelogenous, Chronic, BCR-ABL Positive CML tissues and cells Interaction(TGFBR1/ABCC2) Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay We found that the expression of ADORA2A-AS1 was upregulated in CML. Besides, ADORA2A-AS1 promoted the expression of transforming growth factor-beta receptor 1 (TGFBR1) and ATP binding cassette subfamily C member 2 (ABCC2) via sponging miR-665, thereby exerting a tumor-promoting activity. Yes Further, knockdown of ADORA2A-AS1 inhibited the proliferation, induced apoptosis, arrested cell cycle, and enhanced imatinib sensitivity in CML cells. 35034552 ADPGK-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells Interaction(miR-205-5p/ZEB1) In Vivo Experiment//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//Microarray//IHC//Transwell Assay MiR-205-5p was low-expressed while ZEB1 and ADPGK-AS1 were high-expressed in PC tissues and cells compared with the normal. Dual-luciferase reporter gene assay proved that ADPGK-AS1 could directly target miR-205-5p and miR-205-5p could directly target ZEB1 3'UTR. Yes The expression of MiR-205-5p was negatively correlated with proliferation, migration and invasion, and positively correlated with apoptosis rate of PC cells, while ZEB1 and ADPGK-AS1 had an inversed effect. Further in vitro and in vivo investigation indicated that epithelial-mesenchymal transition (EMT) could be restrained by miR-205-5p through targeting ZEB1. ADPGK-AS1 strongly promoted the tumorigenesis via downregulating miR-205-5p expression and induced the EMT process in vivo. 29667486 AFAP1-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells interaction[ targeting miR-145 ] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The results showed that miR-145 expression was low, whereas AFAP1-AS1 and MTH1 expression was high in TNBC cells and that miR-145 mimics reduced TNBC cell proliferation and invasion, whereas miR-145 knockdown exerted the opposite activity in TNBC cells.This study revealed that AFAP1-AS1 could promote TNBC cell proliferation and invasion via regulation of MTH1 expression through targeting of miR-145. Yes Moreover, knockdown of AFAP1-AS1 reduced tumor cell proliferation and invasion, but miR-145 co-transfection rescued tumor cell viability and colony formation ability. 32376943 ADPGK-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction[targeting miR-542-3p ] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay LncRNA ADPGK-AS1 expression was induced while miR-542-3p expression was reduced in OS tissues and cells.ADPGK-AS1 affected cell proliferation, invasion, migration, and apoptosis via targeting miR-542-3p in OS, providing a theoretical basis and a new therapeutic target for the diagnosis and treatment of OS. Yes Functional experiments showed that inhibition of ADPGK-AS1 could decrease cell proliferation, migration, and invasion, as well as promoted cell apoptosis in OS cells. 31696461 AFAP1-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissue and cells Interaction[suppressing RBM5 ] qRT-PCR//Transwell Assay//Western Blot The expression level of AFAP1-AS1 was significantly higher in prostate cancer samples than that in corresponding ones. AFAP1-AS1 acts as an oncogene in prostate cancer by enhancing cell metastasis and proliferation via suppressing RBM5, which might be a novel therapeutic strategy in treatment for prostate cancer. Yes Additionally, the cell proliferation, migration, and invasion capacities were inhibited after AFAP1-AS1 was knocked down in prostate cancer cells. 31081081 AFAP1-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues and cell lines Interaction[targeting miR-512-3p] Western Blot//Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay AFAP1-AS1 is highly expressed in prostate cancer tissues and cell lines. AFAP1-AS1 regulates miR-512-3p, so as to realize the regulation effect on the proliferation, invasion and migration of prostate cancer cells, and thereby promote the occurrence and development of prostate cancer, so as to provide the corresponding program for the treatment of prostate cancer. The expression level of AFAP1-AS1 is correlated with histological grade and distant metastasis.The overall level of patients with high expression of AFAP1-AS1 is low, and their survival rate is relatively low. Yes Silencing AFAP1-AS1 can significantly increase the proliferation and migration of prostate cancer cells. AFAP1-AS1 silencing induces cell cycle arrest at G0/G1 phase. 31669642 AFAP1-AS1 LncRNA Homo sapiens Prostatic Neoplasms castration-resistant C4-2 cells and NE-like cells Interaction(miR-15b/IGF1R Axis) CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay AFAP1-AS1 level was markedly increased in castration-resistant C4-2 cells and NE-like cells (PC3, DU145, and NCI-H660), compared with androgen-sensitive LNCaP cells. Mechanistically, AFAP1-AS1 functioned as an oncogene in PCa through binding to miR-15b and destroying its tumor suppressor function. Yes Functionally, AFAP1-AS1 knockdown repressed tumor cell proliferation and invasion.  34126893 AFAP1-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Regulation[PTEN-dependent signaling] CCK8//qRT-PCR//Western Blot//Transwell Assay We observed that AFAP1-AS1 expression was significantly upregulated in ccRCC tissues and that patients with high-level expression of AFAP1-AS1 had a shorter overall survival. Downregulation of AFAP1-AS1 resulted in an increase in E-cadherin and a decrease in vimentin. Noticeably, we found that PTEN has a negative correlation with the lncRNA AFAP1-AS1 expression. Further studies verified that PTEN deficiency effectively attenuated the ability of AFAP1-AS1 in promoting ccRCC cell proliferation, invasion, migration, and EMT. Moreover, the similar biological response of silencing AFAP1-AS1 was observed in our ccRCC mice model. Knockdown of AFAP1-AS1 evidently suppressed tumor growth. Taken together, our results provide the evidences that silencing of AFAP1-AS1 inhibits cell proliferation, EMT, and metastasis through PTEN-dependent signaling, and our findings elucidate a novel potential therapeutic target or biomarker for the treatment of ccRCC. We observed that AFAP1-AS1 expression was significantly upregulated in ccRCC tissues and that patients with high-level expression of AFAP1-AS1 had a shorter overall survival. Yes Knockdown of AFAP1-AS1 markedly suppressed the progression of proliferation, invasion, migration, and EMT in ccRCC cells. 30832752 AFAP1-AS1 LncRNA Homo sapiens Retinoblastoma RB tissues and cells Interaction(miR-545-3p/GNB1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Increased AFAP1-AS1 and GNB1 expression in RB tissues and cells was confirmed by RT-qPCR;conversely, miR-545-3p was found to be downregulated in RB tissues and cells.Moreover, AFAP1-AS1 was found to target miR-545-3p. The anti-miR-545-3p treatment phenocopied the effect of AFAP1-AS1 overexpression and promoted RB cell growth in vivo. miR-545-3p was found to directly target GNB1. GNB1 silencing resulted in reduced proliferation and migration of RB cells and attenuated the oncogenic effect of the miR-545-3p inhibitor. Yes AFAP1-AS1 overexpression resulted in increased proliferation and migration of RB cells, whereas AFAP1-AS1 silencing resulted in decreased proliferation and migration of RB cells. 35193469 AFAP1-AS1 LncRNA Homo sapiens Melanoma melanoma cell lines regulation[miR-653-5p/RAI14 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay AFAP1-AS1 was highly expressed in melanoma cell lines. AFAP1-AS1 exerts its oncogenic function in melanoma by targeting miR-653-5p/RAI14 axis. Yes Suppression of AFAP1-AS1 impaired cell proliferation, migration, invasion and EMT in melanoma. 32228518 AFAP1-AS1 LncRNA Homo sapiens Pituitary Neoplasms pituitary adenoma tissues Regulation Western Blot//Transfection//qRT-PCR//Cell Proliferation Assay//Cell Cycle Assay We observed that the expression of AFAP1-AS1 was considerably higher in the pituitary adenoma tissues as compared to its expression in the adjacent tissues. Finally, knockdown of AFAP1-AS1 also promoted the expression of PTEN and inhibited the expression of PI3K and p-AKT. Yes Additionally, knockdown of AFAP1-AS1 inhibited the proliferation, arrested the cell cycle in the G1-to-S transition phase, and promoted apoptosis in GH3 and MMQ cells. 31938218 AFAP1-AS1 LncRNA Homo sapiens laryngeal carcinoma LC patients Expression(highly expressed) Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay Herein, a remarkable elevation of lncRNA AFAP1-AS1 was observed in LC patients. And higher lncRNA AFAP1-AS1 level was correlated to worse clinical pathological characteristics. Yes Moreover, lncRNA AFAP1-AS1 silencing was revealed to repress TU212 malignant phenotypes. 35968243 AFAP1-AS1 LncRNA Homo sapiens Endometriosis ectopic endometrial tissues Interaction[ZEB1] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//ELISA//IHC//EdU Staining//Transwell Assay AFAP1-AS1 levels were much higher in ectopic endometrial tissues than that in eutopic tissues.The knockdown of AFAP1-AS1 significantly inhibited expression from promoter site pGL3-P886 of the EMT-related transcription factor ZEB1. The size of subcutaneous tumours in nude mice was significantly reduced after down-regulation of AFAP1-AS1 expression. Yes After knockdown of AFAP1-AS1, the morphology of endometrial epithelial cells varied from spindle fiber shaped to polygon epithelioid and proliferation, migration, and invasion were each inhibited. 30506548 AFAP1-AS1 LncRNA Homo sapiens Endometriosis ESCs Interaction(miR-424-5p/ STAT3/TGF-β/Smad signaling pathway) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay AFAP1-AS1 knockdown or miR-424-5p overexpression inhibited proliferation and migration, and promoted apoptosis in ESCs. Moreover, AFAP1-AS1 activated the STAT3/transforming growth factor-β1 (TGF-β1)/Smad2 axis via directly targeting miR-424-5p. Yes In addition, knockdown of AFAP1-AS1 repressed the expression of ki-67 and Bcl-2, and promoted the levels of cleaved caspase-3 and Bax. Furthermore, knockdown of AFAP1-AS1 inhibited the conversion of E-cadherin to N-cadherin and the expression of Snail. 33949053 AFAP1-AS1 LncRNA Homo sapiens Endometriosis Exo of ESCs Interaction(miR-15a-5p/BCL9) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay//Bioinformatics Analysis//IF The Exo was successfully isolated from ESCs and we observed high expression of AFAP1-AS1 and BCL9 but low expression of miR-15a-5p in EMS. AFAP1-AS1 bound to BCL9, which was targeted by miR-15a-5p in EMS. In vivo experiments in nude mice revealed that inhibition of Exosomal AFAP1-AS1 suppressed migration and invasion of EcESCs through miR-15a-5p/BCL9. Yes Moreover, Exo derived from EcESCs could deliver AFAP1-AS1 to EcESCs and thus promoting proliferation, migration, and invasion of ESCs. 35513844 AFAP1-AS1 LncRNA Homo sapiens gallbladder carcinoma GBC cell Interaction(AFAP1-AS1/hsa-miR-15a-5p/bcl-2 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay In SGC-996 and NOZ cells, AFAP1-AS1 was significantly expressed and hsa-miR-15a-5p was modestly expressed. In addition, AFAP1-AS1 bound hsa-miR-15a-5p and hsa-miR-15a-5p targeted bcl-2. Increased bcl-2 expression was observed in the GBC cells. AFAP1-AS1 may regulate GBC cell proliferation and apoptosis via has-miR-15a-5p to mediate bcl-2 expression. Yes Transfection of the hsa-miR-15a-5p inhibitor elevated proliferation of SGC-996 and NOZ cells and decreased apoptosis, whereas transfection of si-AFAP1-AS1 reduced the proliferation rate and increased apoptosis. 35404727 AFAP1-AS1 LncRNA Homo sapiens Hirschsprung Disease intestinal tissue regulation[AFAP1-AS1/microRNA-195/E2F3 axis ] CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay AFAP1-AS1 was reduced in HSCR patients. Altogether, AFAP1-AS1 silencing acts as an endogenous RNA by interacting with miR-195 to alter E2F3 expression, thus conferring repressive effects on ENCSC activity and promoting HSCR progression. Yes Meanwhile, knockdown of AFAP1-AS1 reduced the cell migratory and proliferative capacities and facilitated cell apoptosis along with G0/G1 phase arrest. 32959905 AFAP1-AS1 CircRNA Homo sapiens Thyroid Cancer, Papillary Expression [highly expressed] qRT-PCR//Wound Healing Assay//Colony Formation Assay//Transwell Assay Results Compared with the paracancerous tissue, the expression level of AFAP1-AS1 mRNA in the papillary thyroid carcinoma tissue significantly increased. Yes Knockdown of AFAP1-AS1 significantly reduced the colony-forming ability, invasion and migration ability of TPC-1 cells. Compared with shNC group and control group, knockdown of AFAP1-AS1 significantly reduced the mRNA and protein expression of snail2, vimentin and β-catenin. 33441229 AFAP1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissuses Interaction(CCNA2) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RNA-seq//Cell Cycle Assay Bioinformatics analyses indicated that AFAP1-AS1 was upregulated in OSCC. Further research indicated that AFAP1-AS1 regulated OSCC cell proliferation by targeting CCNA2. Overexpression of AFAP1-AS1 was positively correlated with lymph node metastasis, tumor stage, and pathological grade. Yes Down-regulation of AFAP1-AS1 in OSCC led to decreased proliferation in vitro and, notably, inhibition of tumor growth in vivo. 34703311 AFAP1-AS1 LncRNA Mus musculus Pancreatic Neoplasms PC tissues Interaction[binding to miR-384] RNA Pull-Down//Western Blot//ISH//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay High expression of AFAP1-AS1 and ACVR1 with low expression of miR-384 were detected in PC tissues. Taken together, AFAP1-AS1 functions as an endogenous RNA by competitively binding to miR-384 to regulate ACVR1, thus conferring inhibitory effects on PC cell stemness and tumorigenicity. Yes The knockdown of AFAP1-AS1 or overexpression of miR-384 was confirmed to impair PC cell self-renewal ability, tumorigenicity, invasion, migration and stemness. 30819221 ADPGK-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[sponging miR-3196] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay ADPGK-AS1 was increased in GC tissues and cell lines. GC patients with an increased expression of ADPGK-AS1 had a poor prognosis compared to those with a reduced expression. We unveiled that ADPGK-AS1 could promote GC progression via sponging miR-3196 and therefore upregulating KDM1B, providing a novel prognostic biomarker and therapeutic target for GC patients. Yes ADPGK-AS1 knockdown led to inhibition of GC cell proliferation and migration. 30944080 ADPGK-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Regulation[miR-3196/OTX1 axis ] qRT-PCR//Luciferase Report Assay//RIP ADPGK-AS1 expression level was upregulated in BC tissues and cell lines. Currently, ADPGK-AS1 acted as a competing endogenous RNA (ceRNA) via modulating miR-3196/OTX1 axis in BC. High expression of ADPGK-AS1 predicted poor prognosis for BC patients. Yes Functionally, ADPGK-AS1 promoted cell proliferation, migration, induced epithelial-mesenchymal transition (EMT) process, and suppressed cell apoptosis. 31264061 ADPGK-AS1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cells regulation[ADPGK-AS1/miR-525/FUT1] qRT-PCR//Luciferase Report Assay ADPGK-AS1 was upregulated in CRC tissues and cells.ADPGK-AS1 is upregulated in CRC. The regulatory loop ADPGK-AS1/miR-525/FUT1 exacerbates the progression of CRC by promoting the proliferation, migration, and invasion of tumor cells. Yes Knockdown of ADPGK-AS1 attenuated the proliferative, migratory, and invasive abilities of CRC cells. 32196589 AGAP2-AS1 LncRNA Homo sapiens Glioblastoma GBM tissues and cells Interaction(miR-9-5p-MMP2/MMP9) Bioinformatics Analysis Herein, based on a variety of bioinformatics tools for the reverse prediction of target genes associated with the prognosis of GBM, a ceRNA network of AGAP2-AS1-miR-9-5p-MMP2/MMP9 was constructed, and a potential therapeutic target for GBM was identified. Yes Enrichment analysis predicted that the ceRNA regulatory network participates in the processes of cell proliferation, differentiation, and migration. 33889541 AGAP2-AS1 LncRNA Homo sapiens Glioma glioma tissue and cell lines Regulation[Wnt/β-catenin signaling pathway] qRT-PCR In this study, we found that lncRNA AGAP2-AS1 was differentially expressed in glioma tissue samples and cell lines.Higher expression of AGAP2-AS1 was correlated with the lower overall survival of glioma patients. Mechanistically, AGAP2-AS1 upregulated HDGF by sponging miR-15a/b-5p. The function of AGAP2-AS1-miR-15a/b-5p-HDGF axis was confirmed by performing rescue assays. Experimental results suggested that miR-15a/b-5p and HDGF involved in AGAP2-AS1-mediated glioma cell proliferation. Moreover, AGAP2-AS1 and HDGF were found to activate Wnt/β-catenin signaling pathway in glioma cell lines. In summary, this study demonstrated that AGAP2-AS1 promoted glioma cell proliferation by sponging miR-15a/b-5p to upregulate the expression of HDGF. Higher expression of AGAP2-AS1 was correlated with the lower overall survival of glioma patients. Yes Functionally, AGAP2-AS1 knockdown inhibited glioma cell proliferation and accelerated glioma cell apoptosis. 30684575 AGAP2-AS1 LncRNA Homo sapiens Glioma glioma tissues Expression[Expression[Expression[highly expressed]-expression]-expression] CCK8//qRT-PCR In our results, we found AGAP2-AS1 expression was increased in GBM compared with adjacent normal brain tissues or low-grade glioma tissues, and there was no significantly different between low-grade glioma tissues and normal tissues. Kaplan-Meier survival analysis indicated patients with GBM having high-expression of AGAP2-AS1 had shorter overall survival time than those with low expression of AGAP2-AS1. Yes The loss-of-function studies showed that Expression[down-expression]regulation of AGAP2-AS1 depressed cell proliferation, migration, and invasion, and promoted cell apoptosis in GBM. 30525219 APCDD1L-DT LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Epigenetics(hypermethylation) In Vivo Experiment//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay The expression of APCDD1L-AS1 was downregulated in ccRCC. APCDD1L-AS1 was able to inhibit the progression of ccRCC, and its decreased expression could be caused by DNA hypermethylation and loss of VHL protein expression. Decreased APCDD1L-AS1 expression was related to higher tumor stage and histological grade and shorter RFS (Relapse-free survival). Yes Besides, APCDD1L-AS1 overexpression restrained the growth and metastasis of ccRCC cells in vitro and in vivo. 35414787 AP000695.2 LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues and cell lines Expression(highly expressed) Cell Proliferation Assay//qRT-PCR Here, we discovered that AP000695.2 was significantly upregulated in lung adenocarcinoma tissues compared with healthy adjacent lung tissue and higher in LUAD cell lines than in normal human bronchial epithelial cell lines. A higher expression of AP000695.2 was positively correlated with aggressive clinicopathological characteristics, and AP000695.2 served as an independent prognostic indicator for the overall survival, disease-free survival, and progression-free survival in patients with LUAD. Yes Our in vivo data confirmed that AP000695.2 promotes the proliferation, migration, and invasion of LUAD cells. GSEA results suggested that AP000695.2 co-expressed genes were mainly enriched in immune-related biological processes such as JAK-STAT signaling pathway and toll-like receptor signaling pathway. 35685240 AP000439.2 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC-exo Interaction(STAT3 /TGF-β and IL-10 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//migration assay//RNA-seq LncRNA AP000439.2 was highly enriched in the ccRCC-exo. Nuclear-localized AP000439.2 directly interacted with signal transducer and activator of transcription 3 (STAT3) proteins and phosphorylated STAT3 in macrophages. RNA-Seq results showed overexpression of AP000439.2 activated NF-κB signaling pathway. Silencing of STAT3 suppressed overexpression of AP000439.2-induced up-regulation of TGF-β and IL-10 expression, and p65 phosphorylation. Yes Overexpression of exosomal AP000439.2 promoted M2 macrophage polarization whereas AP000439.2-deficient exosome had the opposite effects. AP000439.2-deleted exosome inhibited tumor growth in vivo. 36153596 AOC4P CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Regulation[MAPK signaling pathway] Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay The expression of lncRNA AOC4P in gastric cancer tissues was higher than that in adjacent tissues.Inhibition of lncRNA AOC4P expression can inhibit cell proliferation, migration and invasion, promoting cell apoptosis to some extent. Inhibition of lncRNA AOC4P expression also can result in the decreased expression levels of extracellular-signal-regulated kinase 1 (ERK1), c-Jun N-terminal kinases (JNK) and p38 proteins. OS or DFS time were significantly shortened in patients with gastric cancer with high expression of lncRNA AOC4P. Yes Inhibition of lncRNA AOC4P expression can inhibit cell proliferation, migration and invasion, promoting cell apoptosis to some extent. 31696472 AOC4P LncRNA Homo sapiens Stomach Neoplasms GC tissue and cell lines Interaction(UHRF1) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay UPAT was overexpressed in GC tissue and cell lines. UPAT expression in GC was positively correlated with UHRF1 expression. UHRF1 overexpression offset the inhibitory effects of UPAT down-regulation on cell proliferation, migration, invasion and cell cycle, and partially reversed the positive effect of UPAT down-regulation on apoptosis. Decreased UPAT level was associated with higher overall survival. Yes Down-regulation of UPAT diminished cell proliferation, Cyclin D1 expression, and migration and invasion rates, increased apoptosis rate and cleaved caspase-3 expression, and blocked cell cycle in AGS and NCI-N87 cells. 35294719 AOC4P LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC samples and cells regulation[Wnt/β-catenin pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay AOC4P was lowly expressed in NSCLC samples and cells. In conclusion, AOC4P overexpression suppresses viability and invasion and induces apoptosis in NSCLC cells via inhibition of the Wnt/β-catenin pathway. Yes Overexpression of AOC4P inhibited viability, the expression of MMP-2 and MMP-9, and invasion of NSCLC cells. Apoptosis and caspase-3/7 activity were suppressed in response to AOC4P overexpression in NSCLC cells. AOC4P overexpression suppressed tumor growth in a xenograft mouse model. 32325081 AOC4P LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues and cell lines Expression[lower expressed] qRT-PCR//Western Blot//Transwell Assay The results showed that AOC4P expression levels were decreased in EOC tissues and cell lines, and that the under-expression of AOC4P was positively correlated with FIGO stage and lymph node metastasis. The results showed that AOC4P expression levels were decreased in EOC tissues and cell lines, and that the under-expression of AOC4P was positively correlated with FIGO stage and lymph node metastasis. Yes Furthermore, the knockdown of AOC4P expression in poorly metastatic EOC cell lines remarkably facilitated cell migration/invasion while the overexpression of AOC4P in highly metastatic EOC cell lines reduced the metastatic ability of these cells in vitro. 32334623 ANXA2P2 LncRNA Homo sapiens Glioblastoma glioma tissue samples and cells regulation[ANXA2P2/miR-9/LDHA axis ] qRT-PCR//MTT//Luciferase Report Assay The expression of ANXA2P2 showed to be dramatically upregulated within glioma tissue samples and cells. In conclusion, ANXA2P2/miR-9/LDHA axis modulates the aerobic glycolysis progression in glioma cells, therefore affecting glioma cell proliferation. Yes Knocking down ANXA2P2 within glioma cells significantly inhibited cell proliferation and aerobic glycolysis, as manifested as decreased lactate and increased glucose in culture medium, and downregulated protein levels of glycolysis markers, GLUT1, HK2, PFK, as well as LDHA. miR-9 was predicted to target both lncRNA ANXA2P2 and LDHA. 32707073 ANXA2 CircRNA Homo sapiens Lung Neoplasms lung cancer cell lines and tissues Interaction(miR-33a-5p/PDPK1 ) TUNEL//Western Blot//Transfection//Tunel//qRT-PCR//PCR//IF The expression abundance of circANXA2 is high in lung cancer cell lines and tissues. circANXA2 further affects downstream PDPK1 expression by regulating miR-33a-5p and thereby affecting the malignancy of the lung cancer cells. circANXA2 inhibits miR-33a-5p activity by directly interacting with miR-33a-5p. circANXA2 regulates the transcription of the miR-33a-5p downstream target gene PDPK1 and affects the malignant progression of lung cancer. Yes Knocking down of circANXA2 inhibits the proliferation and clonogenesis of the lung cancer cells. Knocking down circANXA2 promotes apoptosis. 34992655 ANKRD40CL LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cells interaction[sponging miR-490-3p] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay LINC00483 and MAPK1 levels were increased in gastric cancer tissues and cells.Besides, inhibition of LINC00483 decreased xenograft tumor growth by regulating miR-490-3p/MAPK1 axis. Yes Knockdown of LINC00483 or MAPK1 inhibited cells viability, migration and invasion but promoted apoptosis in gastric cancer cells. Moreover, MAPK1 overexpression attenuated the effect of LINC00483 knockdown on gastric cancer development. 32293550 ANKRD40CL LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[LINC00483/miR-204-3p/FMNL2 axial] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay In the present study, we found a novel lncRNA, long intergenic non-protein coding RNA 483 (LINC00483), which was upregulated in CRC. LINC00483/miR-204-3p/FMNL2 axial might be a novel target in molecular treatment of CRC. We also illustrated that upregulated LINC00483 was correlated with poor clinicopathological features of patients with CRC. Yes Functionally, we displayed that a knockdown of LINC00483 suppressed LOVO and HT29 cells proliferation and metastatic ability. 30594388 ANKRD40CL LncRNA Homo sapiens Colorectal Neoplasms CRC biopsies Regulation(HNF4α) qRT-PCR LINC00483 was downregulated in CRC biopsies and metastases and its decreased levels were associated with severe clinical features.Moreover, we found that LINC00483 is potentially under negative control of transcription factor HNF4α. In conclusion, we propose that LINC00483 is a tumor suppressor in CRC that, through an RNA-RNA network, may control cell migration and participate in proliferation signaling. Yes Inhibition of the MAPK pathway and cell cycle arrest by starvation induced an upregulation of LINC00483, while the epithelial to mesenchymal transition activation by TGFβ-1 and IL-6 caused its down-modulation.Moreover, enforced expression of LINC00483 provoked a slowing down of cell migration rate without affecting cell proliferation. 33552987 ANKRD40CL LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues and cells Interaction(miR-19a-3p/TBK1/MAPK axis) qRT-PCR//Luciferase Report Assay//IHC//EdU Staining Our data showed that LINC00483 was significantly upregulated in PDAC compared to normal tissue. Subsequently, we found that miR-19a-3p binds to TBK1 in PDAC and LINC00483 could regulate PDAC cell progression by regulating miR-19a-3p via the TBK1/MAPK pathway. High level of LINC00483 was correlated with advanced clinical stage, tumor invasion and metastasis, and adverse prognosis in PDAC patients. Yes LINC00483 suppression inhibited proliferation and invasion in vitro and tumor development in vivo via modulation of miR-19a-3p expression. 35433983 ANKRD40CL LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Regulation[miR-508-3p/RGS17 axis] Wound Healing Assay//Tunel//qRT-PCR//Luciferase Report Assay//Transwell Assay Linc00483 aberrantly overexpressed in both cervical cancer tissues and cell lines comparing to the Control groups. Knock-down of Linc00483 inhibited the development of cervical cancer by regulating miR-508-3p/RGS17 axis. Yes Knock-down of Linc00483 inhibited cervical cancer cell proliferation, invasion as well as migration, and promoted cell apoptosis. 31454494 ANKRD12 CircRNA Homo sapiens Neoplasms cell line Expression[Expression[Expression[highly expressed]-expression]-expression] PCR//Invasion Assay//Western Blot We performed Real-time PCR analysis on 12 different cell lines from breast, ovarian and lung cancer and normal breast and lung to assess the cell-type specific expression of circANKRD12 (Additional file 1: Figure S1:Fig. ​S1:Fig.2c).2c). Most of these cell lines show a high abundance of both ANKRD12 circRNA and mRNA. Ovarian cancer cell lines show a higher abundance of ANKRD12 circRNA compared to breast and lung cancer cell lines. Yes Silencing of circANKRD12 induces a strong phenotypic change by significantly regulating cell cycle, increasing invasion and migration and altering the metabolism in cancer cells. 31185953 ANAPC7 CircRNA Homo sapiens Pancreatic Neoplasms human pancreatic cancer cells, 3-dimensional spheroids and organoids, mouse models, and clinical specimens Interaction(CREB-miR-373-PHLPP2 axis) In Vivo Experiment//RNA Pull-Down//Luciferase Report Assay//RIP We identified circANAPC7 as a sponge for miR-373, which inhibited tumor growth and muscle wasting in vitro and in vivo. This study identified circANAPC7 as a novel tumor suppressor, which functions through the CREB-miR-373-PHLPP2 axis, leading to AKT dephosphorylation, and cyclin D1 and transforming growth factor-β down-regulation to suppress tumor growth and muscle wasting in pancreatic cancer. Yes We identified circANAPC7 as a sponge for miR-373, which inhibited tumor growth and muscle wasting in vitro and in vivo. 35176309 ALOX12-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cells and tissues Interaction(miR-3171/AGO2) Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay ALOX12-AS1 expression is downregulated in cervical cancer, and over-expression of ALOX12-AS1 could inhibit cervical cancer cells proliferation in vitro. Further, mechanistically investigation revealed that ALOX12-AS1 could interact with AGO2 and sponge miR-3171, thereby antagonizing its' repression of tumor suppressor phosphatase and tensin homolog expression in cervical cancer cell. Yes ALOX12-AS1 expression is downregulated in cervical cancer, and over-expression of ALOX12-AS1 could inhibit cervical cancer cells proliferation in vitro. 34407056 ALMS1-IT1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD patients Regulation(AVL9) Western Blot//Bioinformatics Analysis//Migration Assay//qRT-PCR//Cell Proliferation Assay//Invasion Assay We report that ALMS1-IT1 and AVL9 were both highly expressed in LUAD and correlated with poor outcomes in LUAD patients. In summary, ALMS1-IT1/AVL9 may promote the malignant progression of LUAD, at least in part by regulating the cyclin-dependent kinase pathway. Of note, the prognosis of LUAD patients with low expression of both ALMS1-IT1 and AVL9 was superior to that of other patients. Yes Furthermore, the proliferation, migration and invasion of LUAD cells were decreased in cells lacking ALMS1-IT1, and this decrease could be almost completely reversed through overexpression of AVL9. Gene set enrichment analysis revealed that expression of genes related to the cell cycle pathway is closely related to both the high expression of ALMS1-IT1 and AVL9 in LUAD. 33683834 ALKBH3-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC patients, Huh7 cells Interaction(HIF-1α/ALKBH3-AS1/ALKBH3 ) qRT-PCR The high ALKBH3-AS1 expression was markedly associated with a decreased survival rate of HCC patients. A significant positive correlation between ALKBH3-AS1 and ALKBH3 mRNA levels was confirmed in HCC specimens. ALKBH3-AS1 silencing reduced ALKBH3 expression by stabilizing its mRNA stability in HCC cells. Notably, the impact of ALKBH3 silencing on HCC cells was similar to that of ALKBH3-AS1 knockdown. ALKBH3 restoration prominently attenuated the suppressive effects resulting from ALKBH3-AS1 silencing in HCCLM3 cells. Hypoxia-inducible factor-1α (HIF-1α) transcriptionally activated ALKBH3-AS1 expression in hypoxic HCC cells. ALKBH3-AS1 knockdown markedly attenuated cell proliferation and invasion in hypoxic Huh7 cells. The high ALKBH3-AS1 expression was markedly associated with a decreased survival rate of HCC patients. Yes ALKBH3-AS1 knockdown repressed and ALKBH3-AS1 overexpression enhanced HCC cell invasion and proliferation. ALKBH3-AS1 silencing restricted HCC growth in vivo. 36098205 ALAHM LncRNA Homo sapiens Adenocarcinoma of Lung serum EVs Interaction(AUF1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transwell Assay//Wound Healing Assay//qRT-PCR//FISH//RIP//ELISA//Colony Formation Assay//IF Highly enriched lncRNA-ALAHM was identified from serum EVs of lung adenocarcinoma (LUAD) patients with liver metastasis by high-throughput sequencing. As results, ALAHM expression in LUAD cell EVs was significantly increased. LUAD-cell-derived EVs overexpressing ALAHM significantly promoted lung cancer liver metastasis in model mice. ALAHM of LUAD cell EVs also promotes hepatocyte parasecretion of HGF by binding with AUF1 and increases the proliferation, invasion, and migration of LUAD cells. Yes The effects of ALAHM on hepatocyte paracrine HGF as well as proliferation, invasion, and migration of LUAD cells were observed in vitro. 35281743 AP001625.6 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[lower expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 APOA1-AS LncRNA Homo sapiens Pre-Eclampsia placental tissues of EOSPE patients and cells Expression(highly expressed) qRT-PCR//ELISA Increased APOA1-AS was found in the placental tissues of EOSPE patients. Furthermore, APOA1-AS siRNA improved pregnancy outcomes in PE rats with increased expression of vascular endothelial growth factor, placental growth factor, and fms-like tyrosine kinase receptor (Flt-1) but decreased expression of E-cadherin, intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Yes Furthermore, APOA1-AS siRNA improved pregnancy outcomes in PE rats with increased expression of vascular endothelial growth factor, placental growth factor, and fms-like tyrosine kinase receptor (Flt-1) but decreased expression of E-cadherin, intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). 35130745 AGAP2-AS1 LncRNA Homo sapiens Esophageal Neoplasms tumor tissues regulation[miR-195-5p] qRT-PCR The expression of AGAP2-AS1, miR-195-5p, and FOSL1 in tumor tissues isolated from EC patients and EC cell lines was determined by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), the results of which illustrated that AGAP2-AS1 and FOSL1 were increased while miR-195-5p was reduced in EC. Yes Next, the ectopic expression, knockdown, and reporter assay experiments were all employed to elucidate the mechanism of AGAP2-AS1/miR-195-5p/FOSL1 in the processes of EC cell proliferation, cell cycle, apoptosis, invasion, and migration as well as tumor growth. Knockdown of AGAP2-AS1 or overexpression of miR-195-5p reduced EC cell proliferation, migration, and invasion, blocked cell cycle entry, and elevated apoptosis. 32199129 APOC1P1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Expression[highly expressed] Cell Proliferation Assay//qRT-PCR LncRNA APOC1P1 expression was increased in ccRCC tissues compared with normal kidney tissues (P < 0.001). Its expression was higher in the Fuhrman grade III and IV group than in the Fuhrman grade I and II group (P < 0.05) and significantly upregulated in the advanced stage group (P < 0.05). Kaplan-Meier analyses revealed that elevated LncRNA APOC1P1 expression was significantly associated with poor overall survival (P < 0.05) but may not be an independent prognostic factor. Yes Knockdown of LncRNA APOC1P1 inhibited cell proliferation, induced apoptosis, and arrested cells at the G1/S phase (P < 0.05). Silencing of LncRNA APOC1P1 also led to decreased cell migration and invasion (P < 0.05). 31871500 ARHGAP10 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues ,cell lines Regulation[miR-150-5p/GLUT-1 Axis ] CCK8//FISH//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay Thus, the present study aims at investigating the role of circARHGAP10 in NSCLC progression, which has been observed to be significantly upregulated in both NSCLC tissues and cell lines with profile analysis.Silencing circARHGAP10 also suppressed proliferation and metastasis by targeting the miR-150-5p/GLUT1 axis in NSCLC, which was confirmed with a luciferase reporter assay. Overexpression of GLUT1 or downregulation miR-150-5p will recover NSCLC cell proliferation and metastasis after a knockdown of circARHGAP10. A higher expression of circARHGAP10 also leads to a poor prognosis in NSCLC patients with fluorescence in situ hybridization (FISH). Yes Silencing circARHGAP10 also suppressed proliferation and metastasis by targeting the miR-150-5p/GLUT1 axis in NSCLC, which was confirmed with a luciferase reporter assay. Overexpression of GLUT1 or downregulation miR-150-5p will recover NSCLC cell proliferation and metastasis after a knockdown of circARHGAP10. 31561126 ARFRP1 LncRNA Homo sapiens Osteoarthritis OA cartilage tissues regulation[miR-15a-5p/TLR4 axis] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay ARFRP1 and TLR4 levels were increased and miR-15a-5p level was decreased in OA cartilage tissues and lipopolysaccharides (LPS)-induced chondrocytes. ARFRP1 knockdown inhibited LPS-induced the injury of chondrocytes. Our findings confirmed that ARFRP1 mediated LPS-induced the injury of chondrocytes through regulating NF-κB pathway by modulation of miR-15a-5p/TLR4 axis, providing theoretical basis for the treatment of OA patients. Yes ARFRP1 knockdown inhibited LPS-induced the injury of chondrocytes. 32931797 ARAP1-AS1 LncRNA Homo sapiens Breast Neoplasms BC cell lines regulation[miR-2110/HDAC2/PLIN1 axis] RNA Pull-Down//ChIP//Western Blot//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay First of all, the GEPIA data suggested that ARAP1-AS1 was highly expressed in breast invasive carcinoma (BRAC) tissues compared with the normal breast tissues. Meanwhile, the expression of ARAP1-AS1 was greatly up-regulated in BC cell lines.To sum up, ARAP1-AS1 serves a tumor-promoter in BC development through modulating miR-2110/HDAC2/PLIN1 axis, which may help to develop novel effective targets for BC treatment. Yes ARAP1-AS1 knockdown led to repressed proliferation, strengthened apoptosis and blocked migration of BC cells. 32110804 ARAP1-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell lines Expression[highly expressed] Flow Cytometry//MTT//Western Blot LncRNA ARAP1-AS1 is highly expressed in lung cancer tissues and cells. Yes Knockdown of LncRNA ARAP1-AS1 can significantly inhibit the proliferation and clonal formation of lung cancer cells and induce G0/G1 cell cycle arrest.Furthermore, knockdown of ARAP1-AS1 can also notably inhibit the growth of lung cancer cells and substantially reduce the expression of Ki-67 in tumor-bearing tissues in nude mice. 33447422 ARAP1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation[Wnt/β-Catenin Signaling Pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay ARAP1-AS1 was highly expressed in CRC tissues and cell lines. YY1 transcription factor (YY1) enhanced the transcription activity of ARAP1-AS1. The YY1/ARAP1-AS1 axis promoted CRC cell migration and invasion. YY1/ARAP1-AS1 could regulate the Wnt/β-catenin signaling pathway. Yes ARAP1-AS1 knockdown suppressed cell migration, invasion, and epithelial-mesenchymal transition (EMT). 31173500 ARAP1-AS1 LncRNA Homo sapiens Ovarian Neoplasms tissues and cells Interaction(miR-4735-3p /PLAGL2) qRT-PCR//MTT//RIP Compared to normal samples and cells, upregulation of ARAP1-AS1 was observed in tissues and cells of ovarian cancer. Of note, ARAP1-AS1 contributed to the malignant phenotypes of ovarian cancer cells through modulation of miR-4735-3p/PLAGL2 axis, revealing ARAP1-AS1 as a promising therapeutic target for ovarian cancer patients. Yes Therewith, it was disclosed that knockdown of ARAP1-AS1 alleviated the carcinogenicity of ovarian cancer cells. 34149172 ARAP1-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cells Interaction(miR-3918/KIF20A Axis) qRT-PCR//RIP ARAP1-AS1 and KIF20A were overexpressed in bladder cancer, while miR-3918 was underexpressed. miR-3918 was sponged by ARAP1-AS1, and targeted KIF20A. In addition, miR-3918 expression was inversely correlated with ARAP1-AS1 and KIF20a expression levels in bladder cancer tissues. In addition, the rescue experiment showed that interference with miR-3918 could reverse the effect of low ARAP1-AS1 or KIF20A expression on bladder cancer cell malignancy. Yes The downregulation of ARAP1-AS1 or KIF20A expression significantly inhibited the viability and proliferation of cancer cells and promoted apoptosis, whereas low expression of miR-3918 or high expression of ARAP1-AS1/KIF20A showed the opposite effect. 35556220 ARAP1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cells regulation[ARAP1-AS1/EZH2/DUSP5 axis ] CCK8//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay In the current research, ARAP1-AS1 was discovered to exhibit a high level in cervical cancer cells. Finally, rescue assays certified the oncogenic function of ARAP1-AS1/EZH2/DUSP5 axis in cervical cancer. Yes Besides, the knockdown of ARAP1-AS1 repressed cell proliferative and migratory capacities in cervical cancer, as detected by loss-of-function assays including CCK-8, EdU, colony formation, and transwell assays. 32985327 ARAP1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer (CC) tissues, cell lines and serum Expression[highly expressed] RNA Pull-Down//ChIP//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Here, we focused on an oncogenic lncRNA, ARAP1 antisense RNA 1 (ARAP1-AS1), which was notably upregulated in cervical cancer (CC) tissues, cell lines and serum. High ARAP1-AS1 expression was closely associated with larger tumor size, advanced FIGO stage as well as lymph node metastasis. Yes In vitro and in vivo assays showed that knockdown of ARAP1-AS1 inhibited, while overexpression of ARAP1-AS1 promoted CC cell growth and dissemination. 31953923 ARAP1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC samples Interaction(miR-149-3p and POU2F2) In Vivo Experiment//IHC//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of ARAP1-AS1 was enhanced in CC samples, while miR-149-3p was markedly suppressed. ARAP1-AS1 downregulated miR-149-3p via sponging it. ARAP1-AS1 and miR-149-3p exhibited a negative correlation in CC samples. On the other hand, ARAP1-AS1 enhanced the expression of POU2F2, which was validated as a target gene of miR-149-3p. Yes Additionally, ARAP1-AS1 overexpression enhanced the viability, migration, and invasion of CC cells. 33965958 ARAP1-AS1 LncRNA Homo sapiens Thyroid Neoplasms TC cell lines and tissues Interaction(miR-516b-5p/PDE5A axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay ARAP1-AS1 and PDE5A were evidently upregulated in the TC cell lines and tissues whereas miR-516b-5p was poorly expressed. ARAP1-AS1 had been revealed to be correlated negatively to miR-516b-5p. Finally, we demonstrated that the miR-516b-5p inhibitor was capable of reversing ARAP1-AS1-knockdown's repressive effects on TC cell development by means of regulating PDE5A expression. Yes ARAP1-AS1 silencing in TC cells hampered cell proliferation, reduced their viability and boosted apoptosis. Moreover, it inhibited tumor growth in vivo. 36730555 ARAP1-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC cells Interaction(miR-361-3p/placental growth factor axis) RNA Pull-Down//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay The results showed that the levels of ARAP1-AS1 and PGF increased in ccRCC cells, while miR-361-3p expression decreased. Moreover, ARAP1-AS1 sponges miR-361-3p to increase PGF expression. In conclusion, our study revealed that ARAP1-AS1 enhanced the malignancy of ccRCC cells by regulating the miR-361-3p/PGF axis. Yes Cell functional experiments showed that cell proliferation and migration were inhibited by silencing ARAP1-AS1 or PGF, while miR-361-3p inhibitor or PGF overexpression could relieve the inhibitory effect of silencing ARAP1-AS1 on ccRCC cells. 34516333 AQP4-AS1 LncRNA Homo sapiens Diabetes Mellitus clinical samples, Müller cells Regulation(AQP4) In Vivo Experiment//Transfection AQP4-AS1 was significantly increased in the clinical samples of diabetic retinopathy patients, high glucose-treated Müller cells, and diabetic retinas of a murine model. Mechanistically, AQP4-AS1 regulated retinal neurovascular dysfunction through affecting AQP4 levels. Yes AQP4-AS1 silencing in vivo alleviated retinal neurodegeneration and vascular dysfunction as shown by improved retinal capillary degeneration, decreased reactive gliosis, and reduced RGC loss. AQP4-AS1 directly regulated Müller cell function and indirectly affected endothelial cell and RGC function in vitro. 35172268 APTR LncRNA Homo sapiens Stomach Neoplasms gastric tumor samples Expression(lower expressed) Bioinformatics Analysis LncRNA APTR is lower expressed in gastric tumor samples and low expression of APTR predicts a poor diagnosis and outcome in GC patients. Silencing APTR promotes gastric cancer proliferation and invasiveness. APTR expression is negatively correlated with inflammatory signaling in the gastric tumor microenvironment. LncRNA APTR is lower expressed in gastric tumor samples and low expression of APTR predicts a poor diagnosis and outcome in GC patients. Yes Silencing APTR promotes gastric cancer proliferation and invasiveness. APTR expression is negatively correlated with inflammatory signaling in the gastric tumor microenvironment. 36075114 APTR LncRNA Homo sapiens Osteosarcoma OS tissues and OS cell lines Regulation[APTR/miR-132-3p/YAP1 axis] qRT-PCR Herein, APTR expression was demonstrated to be significantly upregulated in OS tumor tissues and four OS cell lines (including MG63, 143B, Saos-2, and HOS) compared with the adjacent tissues and human osteoblast cell line hFOB1.19, respectively. Also, Yes-associated protein 1 (YAP1) was determined as an inhibitory target of miR-132-3p. Moreover, our findings demonstrated that the repression of YAP1 protein expression and the suppression of Ki-67, MMP9, and Bcl2 expression induced by APTR knockdown required increased miR-132-3p. Thus, APTR contributed to OS progression through repression of miR-132-3p and upregulation of YAP1 expression. Therefore, we have uncovered a novel regulatory mechanism by which the APTR/miR-132-3p/YAP1 axis can regulate OS progression. Yes In functional terms, knockdown of APTR and overexpression of miR-132-3p both, remarkably repressed human OS cell proliferation, invasion and migration, and induced apoptosis. 30317613 APTR LncRNA Homo sapiens uterine fibroid UL tumor tissues Interaction(Erα/Wnt pathway ) In Vivo Experiment//Western Blot//RIP//FISH//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay We found that lncRNA Alu-mediated p21 transcriptional regulator (APTR) showed higher expression in UL tumor tissues compared with that in normal uterine tissues. The results showed that APTR function was suppressed. APTR increased the expressions of the proteins in the Wnt pathway, and inhibiting ERα eliminated these responses. In conclusion, our data suggest that APTR promoted leiomyoma cell proliferation through the Wnt pathway by targeting ERα, suggesting a new role of APTR in the Wnt signaling pathway in UL. Yes APTR induced cell proliferation and colony formation both in vitro and in vivo. 33777725 APPAT LncRNA Homo sapiens Breast Neoplasms cell lines regulation[ miR-328a/Pkp1 signal pathway ] qRT-PCR//Luciferase Report Assay//Western Blot The expressions of lncRNA APPAT, Pkp1 protein levels and miR-328a were commonly expressed in breast cancer cells. LncRNA APPAT regulated the proliferation, migration, invasion of breast cancer by regulating miR-328a/Pkp1 signaling pathway, providing a novel possible strategy for the treatment of breast cancer. Yes The inhibition of lncRNA APPAT expression repressed cell proliferation, migration and invasion in breast cancer and reverse results were found after lncRNA APPAT overexpressing. 32495884 APPAT LncRNA Homo sapiens Atherosclerosis HASMCs Interaction(miR-647) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay APPAT and miR-647 have inverse effects on human aortic smooth muscle cells' (HASMCs) proliferation and migration. APPAT negatively regulated the cell activity, whereas miR-647 did it in a positive way (p<0.05). Three pairs of molecular interplay were found: mutual negative regulation between APPAT and miR-647, APPAT downregulated FGF5, miR-647 regulation on FGF5 (p<0.05). Subcellular location assay confirmed the molecular interaction of APPAT and miR-647. Yes APPAT and miR-647 have inverse effects on human aortic smooth muscle cells' (HASMCs) proliferation and migration. APPAT negatively regulated the cell activity, whereas miR-647 did it in a positive way (p<0.05). 35880306 APP LncRNA Homo sapiens Prostatic Neoplasms Regulation[ lncAPP/miR218 axis] RIP//Luciferase Report Assay The underlying mechanism of lncRNA was investigated by RNA immunoprecipitation, dual-luciferase reporter system assay, etc. Upregulation of lncAPP promoted cell migration and invasion via competitively binding miR218 to facilitate ZEB2/CDH2 expression. In addition, in vivo subcutaneous tumor xenograft models and tail intravenously injection metastatic models were constructed to evaluate lncRNA function. Targeting lncAPP/miR218 axis in cell lines and tumor xenografts restrained tumor progression properties both in vitro and in vivo. These results establish that lncAPP/miR218 axis plays a critical role in PCa progression, and they also suggest new strategies to prevent tumor progression for therapeutic purposes. Yes In vitro and in vivo studies demonstrated that lncAPP enhanced cell proliferation and promoted migration and invasion. 31107971 AL592284.1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Interaction(miR-30a-5p/Vimentin/EMT axis) In Vivo Experiment//IHC//Western Blot//ISH//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay We observed that the levels of AL592284.1 in CC were distinctly increased. Luciferase reporter assay confirmed that miR-30a-5p/Vimentin regulatory axis is the direct downstream of AL592284.1. Rescue experiments indicated that AL592284.1 induced overexpression of Vimentin via sponging miR-30a-5p, resulting in the promotion of CC progression. Yes Functional assays revealed that knockdown of AL592284.1 suppressed the proliferation, migration, invasion and EMT progress of CC cells. 34509725 AL355338 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction( ENO1/EGFR) RNA Pull-Down//Co-IP//Flow Cytometry//qRT-PCR//FISH//RIP//IHC//IF AL355338 was an upregulated glycolysis-associated lncRNA in NSCLC. Mechanistic investigations showed that AL355338 directly bound with alpha-enolase (ENO1) and enhanced the protein's stability by modulating its degradation and ubiquitination. A positive correlation was observed between AL355338 and ENO1 in NSCLC, and ENO1 was subsequently confirmed to be responsible for the oncogenic role of AL355338. Yes Functional assays revealed that AL355338 was critical for promoting aerobic glycolysis and NSCLC progression. 34627260 AL161431.1 LncRNA Homo sapiens Endometrial Neoplasms EC patients, tissues, and cells interaction[targets miR-1252-5p ] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay High expression levels of AL161431.1 were observed in EC patients, tissues, and cells. Our novel results indicate that AL161431.1 targets and binds to miR-1252-5p, resulting in the de-repression of MAPK signaling in EC cells. Yes Loss-of-function experiments validated the carcinogenic role of AL161431.1. 32196580 AL161431.1 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer cells and tissues Expression(highly expressed) In Vivo Experiment//Western Blot//Transwell Assay//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//IHC//IF We found that lncRNA AL161431.1 was highly expressed in pancreatic cancer cells and tissues. Yes Knock down of lncRNA AL161431.1 led to increased cancer cell death and cell cycle arrest. Xenograft growth of SW1990 cells with stable knockdown of lncRNA AL161431.1 in mice was significantly slower than that of SW1990 cells with scrambled control shRNA. 34395245 AK001058 LncRNA Mus musculus Colorectal Neoplasms colorectal cancer tissues Interaction[ADAMTS12] qRT-PCR//Western Blot The results showed that AK001058 overexpression notably accelerated tumor growth. AK001058 overexpression also decreased cell apoptosis, worsened microvessel morphology and increased the expression of VEGFA and angiopoietin II. Moreover, AK001058 decreased the expression of ADAMTS12 by increasing its methylation level. Nevertheless, AK001058 knockdown exerted the opposite function. Therefore, AK001058 knockdown could effectively inhibit tumor growth mostly accounting for decreased cell apoptosis and tumor angiogenesis, which was partly dependent on the high methylation level of ADATS12. Yes The results showed that AK001058 overexpression notably accelerated tumor growth. AK001058 overexpression also decreased cell apoptosis, worsened microvessel morphology and increased the expression of VEGFA and angiopoietin II. Moreover, AK001058 decreased the expression of ADAMTS12 by increasing its methylation level. Nevertheless, AK001058 knockdown exerted the opposite function. Therefore, AK001058 knockdown could effectively inhibit tumor growth mostly accounting for decreased cell apoptosis and tumor angiogenesis, which was partly dependent on the high methylation level of ADATS12. 31632580 AIVR CircRNA Homo sapiens Orthomyxoviridae A549 cells Interaction(CREBBP) Western Blot//ISH//qRT-PCR//FISH//PCR//IP//IF We characterized a novel intronic circRNA, AIVR, that was upregulated in influenza virus-infected A549 cells and found that silencing of AIVR significantly promoted influenza virus replication in A549 cells. We further found that AIVR predominantly localizes in the cytoplasm and works as a microRNA (miRNA) sponge. One of the miRNAs absorbed by AIVR binds the mRNA of CREBBP, which is an important component of the large nucleoprotein complex interferon beta (IFN-β) enhanceosome that accelerates IFN-β production. Yes We characterized a novel intronic circRNA, AIVR, that was upregulated in influenza virus-infected A549 cells and found that silencing of AIVR significantly promoted influenza virus replication in A549 cells. 34281396 AIRN LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Regulation(CUL4A/AIRN ) qRT-PCR Using a quantitative real-time polymerase chain reaction, we corroborated that LncRNA AIRN expression was raised in the HCC tissues and cells. In the cycloheximide-chase assay, the knockdown of LncRNA AIRN enhanced the stability of STAT1 protein. In the immunoprecipitation assay, the knockdown of LncRNA AIRN restrained the cullin 4A (CUL4A)-mediated ubiquitination of STAT1 protein. Yes The cell transfection, MTT and flow cytometry assays expounded that the LncRNA AIRN/STAT1 axis was bound up with the regulation of the proliferation and apoptosis of HCC cells. The in vivo experiments corroborated that the knockdown of LncRNA AIRN restrained the tumor growth of HCC. 33759138 AIRN LncRNA Homo sapiens Diabetic Cardiac Fibrosis diabetic hearts and high glucose (HG)-treated cardiac fibroblasts (CFs) Regulation(m6A-IMP2-p53 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//Cell Cycle Assay//EdU Staining//IF Diabetic hearts showed a significant impairment in cardiac function, accompanied by obviously increased cardiac fibrosis. Interestingly, lncRNA Airn expression was significantly decreased in both diabetic hearts and high glucose (HG)-treated cardiac fibroblasts (CFs). AAV-mediated Airn reconstitution prevented cardiac fibrosis and the development of DCM, while Airn knockdown induced cardiac fibrosis phenotyping DCM. As in vitro, Airn reversed HG-induced fibroblast-myofibroblast transition, aberrant CFs proliferation and section of collagen I. In contrast, Airn knockdown mimicked a HG-induced CFs phenotype. Mechanistically, we identified that Airn exerts anti-fibrotic effects by directly binding to insulin-like growth factor 2 mRNA-binding protein 2 (IMP2) and further prevents its ubiquitination-dependent degradation. Moreover, we revealed that Airn/IMP2 protected p53 mRNA from degradation in m6A manner, leading to CF cell cycle arrest and reduced cardiac fibrosis. As a result, ablation of p53 blunted the inhibitory effects of Airn on fibroblast activation and cardiac fibrosis. Yes AAV-mediated Airn reconstitution prevented cardiac fibrosis and the development of DCM, while Airn knockdown induced cardiac fibrosis phenotyping DCM. As in vitro, Airn reversed HG-induced fibroblast-myofibroblast transition, aberrant CFs proliferation and section of collagen I. 36384975 Airn LncRNA Mus musculus Fatty Liver, Alcoholic liver tissues of AFL C57BL/6mice Regulation( mTOR ubiquitination) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Co-IP//qRT-PCR//RIP//MTT//ELISA LncRNA-AIRN was highly expressed in the liver tissues of AFL C57BL/6mice and oleic acid+alcohol (O+A)treated AML-12cells by using quantitative real-timePCR.Furthermore, the knockdown of lncRNA-AIRN reducedmTOR protein level by promoting the E3 ubiquitin ligase FBXW7-mediated ubiquitination.The lncRNA-AIRN/mTORaxis was involved in the regulation of the mitophagy of O+A treated hepatocytes, which was confirmed by the cell transfection and the MTT assay. Yes Furthermore, the knockdown of lncRNA-AIRN reducedmTOR protein level by promoting the E3 ubiquitin ligase FBXW7-mediated ubiquitination.The lncRNA-AIRN/mTORaxis was involved in the regulation of the mitophagy of O+A treated hepatocytes, which was confirmed by the cell transfection and the MTT assay. 33676386 AIM1-3 LncRNA Homo sapiens Diabetes Mellitus, Type 2 peripheral blood mononuclear cells Regulation(lower expressed) qRT-PCR The microarray analysis revealed that there were 55 lncRNAs and 36 mRNAs differentially expressed in patients with T2DM compared with healthy controls. Notably, lnc-HIST1H2AG-6 was significantly upregulated and lnc-AIM1-3 was significantly downregulated in patients with T2DM, which was validated in a large-scale qRT-PCR examination (90 controls and 100 patients with T2DM). Spearman's rank correlation coefficient revealed that both lncRNAs were correlated with 36 differentially expressed mRNAs. Furthermore, functional enrichment (KEGG and GO) analysis demonstrated that the two lncRNA-related mRNAs might be involved in multiple biological functions, including cell programmed death, negative regulation of insulin receptor signal, and starch and sucrose metabolism. Multivariate logistic regression analysis revealed that lnc-HIST1H2AG-6 and lnc-AIM1-3 were significantly correlated with T2DM (OR = 5.791 and 0.071, respectively, both P = 0.000). Furthermore, the ROC curve showed that the expression of lnc-HIST1H2AG-6 and lnc-AIM1-3 might be used to differentiate patients with T2DM from healthy controls (area under the ROC curve = 0.664 and 0.769, respectively). Yes Notably, lnc-HIST1H2AG-6 was significantly upregulated and lnc-AIM1-3 was significantly downregulated in patients with T2DM, which was validated in a large-scale qRT-PCR examination (90 controls and 100 patients with T2DM). Spearman's rank correlation coefficient revealed that both lncRNAs were correlated with 36 differentially expressed mRNAs. Furthermore, functional enrichment (KEGG and GO) analysis demonstrated that the two lncRNA-related mRNAs might be involved in multiple biological functions, including cell programmed death, negative regulation of insulin receptor signal, and starch and sucrose metabolism. 34092238 AGO2 LncRNA Homo sapiens Breast Neoplasms 26 female breast cancer patients’ tumor tissues and paired paracancerous tissues Interaction(miR-21-5p/FASLG axis) In Vivo Experiment//IHC//Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay By analyzing the CASC7 expression in breast cancer cell lines, both the expression levels of CASC7 in cancer tissues and cell lines were obviously downregulated compared to those in paired paracancerous tissues and normal human epithelial MCF10A cells. We further confirmed that CASC7 functions by regulating miR-21-5p/FASLG axis. Yes A series of functional experiments were conducted to show that the cell proliferation, migration, and invasion were inhibited when CASC7 overexpressed in breast cancer cells. 34889164 AGO2 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Regulation( PI3K/Akt signaling pathway ) qRT-PCR//Transwell Assay//Western Blot The LncRNA-CASC7 expression in colon cancer was considerably decreased than in nearby healthy tissues (P<0.01).Similarly, the expression of lncRNA-CASC7 was decreased in 5 colon cancer cell lines. Overexpression of lncRNA-CASC7 significantly inhibited the expression of proteins Ki-67 and PNCA (associated with proliferation) and proteins N-cadherin, E-cadherin, and vimentin (linked with metastasis). Further studies showed that overexpression of LncRNA-CASC7 could significantly inhibit the PI3K/Akt signaling pathway in colon cancer cells. Its expression level was linked to survival rate, lymph node metastasis, and tumor node metastasis (TNM) stage. Yes The proliferative, invasive, and migratory potential of cells was considerably decreased by lncRNA-CASC7 overexpression. 35070408 AGO2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Interaction(miR-30a-5p/ KLF10/TGF-β/SMAD3 pathway) RNA Pull-Down//IHC//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression levels of CASC7 were increased and the expression levels of miR-30a-5p were reduced in HCC cells and tissues. In HCC tumor tissues, the expression of miR-30a-5p was negatively correlated with the expression of CASC7. Moreover, as a target of miR-30a-5p, KLF10 was regulated by CASC7 and miR-30a-5p, and CASC7 regulated the KLF10/TGF-β/SMAD3 pathway via binding to miR-30a-5p, thereby promoting HCC cell progression. Yes Knockdown of CASC7 and overexpression of miR-30a-5p reduced tumor growth as well as HCC cell proliferation, invasion and migration. 35484972 AGO2 LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[Wnt/β-catenin signaling pathway] Western Blot//qPCR//CCK8//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay We found that CASC7 was downregulated in glioma tissues and cell liens and predicted poor prognosis for patients with glioma. Taken together, all research findings suggested that CASC7 inhibited the progression of glioma via regulating Wnt/β-catenin signaling pathway. We found that CASC7 was downregulated in glioma tissues and cell liens and predicted poor prognosis for patients with glioma. Yes To determine the involvement of CASC7 in the biological processes of glioma, we conducted gain or loss-of function assays in two glioma patients. We found that CASC7 suppressed glioma cell proliferation and induced glioma cell apoptosis. 30661904 AGO2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines interaction[sponging miR-92a] Western Blot//ISH//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Marked downregulation of CASC7 was observed in NSCLC tissues and cell lines, and this downregulation of CASC7 was closely associated with distant metastasis, lymph node involvement and poor overall survival in NSCLC patients. Collectively, the results of the present study indicated that CASC7 may act as a tumor‑suppressive lncRNA that inhibits NSCLC progression by sponging miR‑92a. Marked downregulation of CASC7 was observed in NSCLC tissues and cell lines, and this downregulation of CASC7 was closely associated with distant metastasis, lymph node involvement and poor overall survival in NSCLC patients. Yes Furthermore, overexpression of CASC7 significantly suppressed the proliferation, invasion and migration of the NSCLC cells A549 and H358, and promoted cell apoptosis in vitro. 32626930 AGO2 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Interaction(miR-34a-5p/TP73) Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay CASC7 and TP73 expression were significantly lower, whereas miR-34a-5p expression was higher in PTC tissues than the adjacent normal tissues. Mechanistically, CASC7 acted as a sponge of miR-34a-5p to upregulate TP73 expression. Moreover, miR-34a-5p mimic transfection could abate the CASC7-regulated PTC cell proliferation, migration, and apoptosis. Yes Furthermore, CASC7 overexpression inhibited cell proliferation and migration, whereas facilitated cell apoptosis in human PTC cell lines (K1 and TPC-1). 33706708 AGO2 LncRNA Homo sapiens Neuroblastoma neuroblastoma tissues regulation[downregulating miR-10a] qRT-PCR We observed the downregulation of CASC7 in neuroblastoma tissues compared to non-cancer tissues of neuroblastoma patients. We therefore concluded that lncRNA CASC7 may upregulate phosphatase and tensin homolog by downregulating miR-10a to inhibit neuroblastoma cell proliferation. Yes CASC7 overexpression resulted in inhibition, while miR-10a overexpression resulted in increased proliferation rate of neuroblastoma cells. 32101951 AGAP2-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(HuR/MTA1 ) RNA Pull-Down//IHC//Western Blot//Tunel//CCK8//RIP//Flow Cytometry//qRT-PCR//Colony Formation Assay//ChIP AGAP2-AS1 was overexpressed in BC tissues and cells, and AGAP2-AS1 silencing inhibited cell proliferation but facilitated apoptosis.Physiologically, AGAP2-AS1 bound to HuR to stabilize its own expression, and AGAP2-AS1-HuR complex upregulated H3K27ac levels in the MTA1 promoter region to elevate MTA1 promoter activity and MTA1 expression. H3K27ac upregulation partially-annulled the promotive effect of si-AGAP2-AS1 on BC apoptosis by upregulating MTA1. Yes AGAP2-AS1 was overexpressed in BC tissues and cells, and AGAP2-AS1 silencing inhibited cell proliferation but facilitated apoptosis. si-AGAP2-AS1 in vivo inhibited MTA1 expression to enhance apoptosis and suppress tumor growth. 35369814 AGAP2-AS1 LncRNA Homo sapiens Lung Neoplasms MRC-5 cells Interaction(MyD88/NF-κb signaling) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay We demonstrated that exosomes from the LC patients (cancer-exo) notably increased the metastatic ability of MRC-5 cells, promoting the expressions of the CAF biomarkers and lncRNA AGAP2-AS1. Overexpression of lncRNA AGAP2-AS1 prominently activated MRC-5 cells. Moreover, EIF4A3 was upregulated in the cancer-exo-treated MRC-5 cells, and EIF4A3 was verified to bind with lncRNA AGAP2-AS1 to improve its stability. The MyD88/NF-κB signaling pathway was subsequently proved to be positively regulated by lncRNA AGAP2-AS1, and the promotive role of lncRNA AGAP2-AS1 in LC and activating CAFs was confirmed in vivo. Yes We demonstrated that exosomes from the LC patients (cancer-exo) notably increased the metastatic ability of MRC-5 cells, promoting the expressions of the CAF biomarkers and lncRNA AGAP2-AS1. 36541122 AGAP2-AS1 LncRNA Homo sapiens Colorectal Neoplasms cell lines regulation[miR-4,668-3p/SRSF1 axis] RNA Pull-Down//CCK8//qRT-PCR//RIP//Colony Formation Assay//Transwell Assay In the present study, AGAP2-AS1 was unveiled as highly expressed in CRC cell lines compared to normal cells.AGAP2-AS1 facilitates cell proliferation, motility and EMT in CRC via targeting the miR-4,668-3p/SRSF1 axis. Yes AGAP2-AS1 knockdown suppressed cell proliferation, migration, invasion and the epithelial-to-mesenchymal transition process. 32639657 AGAP2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC cell Interaction(miR-182-5p/CFL1 axis) qRT-PCR//FISH//RIP//Colony Formation Assay//ChIP AGAP2-AS1 expression was significantly elevated in CRC cells and could be transcriptionally activated by E2F Transcription Factor 4 (E2F4). MicroRNA-182-5p (miR-182-5p) was the target downstream molecule of AGAP2-AS1. Furthermore, Cofilin 1 (CFL1) was proved as the target of miR-182-5p. Mechanically, AGAP2-AS1 could boost the CFL1 expression via competitively binding to miR-182-5p in CRC. Yes Down-regulated AGAP2-AS1 could weaken CRC cell growth, migration, invasion, and epithelial-mesenchymal transition (EMT). 34838479 AGAP2-AS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Regulation(LINC-PINT) qRT-PCR//Transwell Assay The expression of AGAP2-AS1 was upregulated in colon cancer tissues compared with that in adjacent normal tissues, and the expression of AGAP2-AS1 in colon cancer tissues was not significantly affected by tumor stages. In addition, we found that the expression of LINC-PINT was downregulated in colon cancer tissues compared with that in adjacent normal tissues and had a reverse correlation with the expression of AGAP2-AS1 in colon cancer tissues. Yes Furthermore, overexpression of AGAP2-AS1 could increase the proliferation, invasion and migration of colon cancer cells, while overexpression of LINC-PINT could attenuate the effects of overexpression of AGAP2-AS1 on the proliferation, migration and invasion of colon cancer cells. We also found that AGAP2-AS1 promoted colon cancer cell proliferation, migration and invasion through the Hippo signaling. 33688258 AGAP2-AS1 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues Expression[lower expressed] qRT-PCR Clinically, AGAP2-AS1 expression was decreased in EOC tissues compared to that in the controls. Low expression of AGAP2-AS1 was associated with advanced FIGO stage, high histological grade, serous subtype and lymph node metastasis in patients with EOC. Yes AGAP2-AS1 inhibited cell migration, invasion and proliferation in vitro. AGAP2-AS1 suppressed tumor growth in vivo. 32742478 AK001058 LncRNA Homo sapiens Colorectal Neoplasms cell lines Interaction[ ADAMTS12] CCK8//qRT-PCR//Western Blot The results indicated that the expression of AK001058 was significantly increased in CRC. In conclusion, AK001058 promotes the proliferation, invasion, migration, and prolonged S stage of CRC by regulating methylation of ADAMTS12. Yes AK001058 also significantly promoted cell proliferation, migration and invasion, and prolonged S stage of CRC, while silencing the expression of AK001058 showed contrary effects. 31632555 AK001903 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Expression[highly expressed] CCK8//qRT-PCR//ISH The findings of the study confirmed that lncRNA-AK001903 was upregulated in CC cells and tissues compared with normal cell line H8 and peritumoral tissues. Yes Knockdown of lncRNA-AK001903 inhibited cell proliferation, invasion and migration in Ca Ski cells. 33363614 AK002107 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[AK002107/miR-140-5p/TGFBR1/EMT ] Western Blot//ISH//qRT-PCR//MTT//Luciferase Report Assay//Microarray//Colony Formation Assay//Transwell Assay The expression of lncRNA AK002107 is frequently upregulated in HCC samples and cell lines. In summary, lncRNA AK002107 functions as an oncogene in tumors by inhibiting miR-140-5p, targeting TGFBR1, and then inducing EMT. The lncRNA AK002107/miR-140-5p/TGFBR1/EMT regulatory network may be a valuable target for the development of novel diagnostic and treatment methods for HCC. Patients with HCC who have elevated lncRNA AK002107 expression exhibit poorer overall survival and disease-free survival. Yes Silencing lncRNA AK002107 expression significantly inhibited HCC cell proliferation, colony formation, and invasion both in vitro and in vivo. 30943320 AK12348 LncRNA Rattus norvegicus Myocardial Reperfusion Injury A/R cardiomyocytes Regulation( PARP and Caspase-3) Western Blot//Transfection//Flow Cytometry//qRT-PCR//IHC The relative level of lncRNA AK12348, LDH release and cell apoptotic rate in A/R cardiomyocytes was significantly higher than that in normal cardiomyocytes. After transfection with siRNA-lncRNA AK12348, LDH release and cell apoptotic rates in A/R cardiomyocytes were reduced, while the values in normal cardiomyocytes had almost no change. The protein expression values of PARP and Caspase-3 in A/R cardiomyocytes were much higher than the Control. After knockdown of lncRNA AK12348, the values decreased. Yes After transfection with siRNA-lncRNA AK12348, LDH release and cell apoptotic rates in A/R cardiomyocytes were reduced, while the values in normal cardiomyocytes had almost no change. The protein expression values of PARP and Caspase-3 in A/R cardiomyocytes were much higher than the Control. After knockdown of lncRNA AK12348, the values decreased. 29398472 AL139385.1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cancer tissues and cell lines. Interaction(hsa-miR-532-5p) Transfection//CCK8//qRT-PCR//migration assay//BrdU In this study, we investigated the role of AL139385.1 in LUAD and found that DNA hypomethylation was positively correlated with AL139385.1 expression in LUAD. Moreover, we uncover that the expression of AL139385.1 in LUAD tissues was significantly higher than that of AL139385.1 expression in adjacent normal tissues.We also found that AL139385.1 was upregulated in LUAD cancer tissues and cell lines. Finally, we constructed a ceRNA network that includes hsa-miR-532-5p and four mRNAs (GALNT3, CYCS, EIF5A, and ITGB4) specific to AL139385.1 in LUAD. Yes Knockdown of AL139385.1 significantly inhibited cell proliferation and migration abilities of LUAD. 35651789 AL110200 LncRNA Homo sapiens Ischemic Stroke THP-1 cells and peripheral blood of coronary heart disease group Mutation(rs901681) qRT-PCR//Transfection//ELISA//Genotyping Increased expression of AL110200 was observed in THP-1 cells under oxidized low-density lipoprotein treatment. AL110200 expression in peripheral blood was significantly higher in the coronary heart disease group than in the controls. Patients carrying rs901681 GG had a lower risk for stroke recurrence at age ≥60 years (p = 0.001), cardiovascular stroke death (p = 0.022) and all-cause mortality (p = 0.034) in the all-age group. Patients carrying rs901681 GG had a lower risk for stroke recurrence at age ≥60 years (p = 0.001), cardiovascular stroke death (p = 0.022) and all-cause mortality (p = 0.034) in the all-age group. Yes Knockdown of AL110200 reduced the adhesive and invasive ability of THP-1 cells. 33934454 AL033381.2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation(PRKRA ) qRT-PCR qRT-PCR analysis revealed that AL033381.2 is upregulated in HCC tissues.Mechanistically, RNA pull-down experiments, mass spectrometry, PathArray™, and RIP were used to determine that AL033381.2 binds to PRKRA and may be involved in AL033381.2-mediated oncogenic functions in HCC cells. Moreover, rescue experiments demonstrated that PRKRA overexpression rescues the abilities of HCC cell proliferation, migration, and invasion that were affected by AL033381.2 knockdown. Yes Through in vitro and in vivo experiments, we found that AL033381.2 dramatically facilitates the growth and metastasis of HCC. 35035655 AKT3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Expression[highly expressed] CCK8//qRT-PCR//Microarray We found that CASC15 was upregulated in NSCLC tissues and cell lines. High expression levels of CASC15 were correlated with malignancies and poor survival rate in NSCLC patients. Yes In addition, we demonstrated that CASC15 knockdown inhibited NSCLC cell proliferation, migration and invasion in vitro. Xenograft model showed CASC15 knockdown significantly suppressed NSCLC tumor growth. 31396336 AKT3 CircRNA Homo sapiens Esophageal Neoplasms esophageal cancer cell and Clinical samples Interaction( miR-17-5p/ RHOC and STAT3) qRT-PCR//Luciferase Report Assay//Western Blot Furthermore, miR-17-5p was screened as the target of circAKT3, and miR-17-5p antagonized the effects of circAKT3 on esophageal cancer cells. Moreover, we identified RHOC and STAT3 as the direct target molecules of miR-17-5p, and circAKT3 facilitated expression of RHOC and STAT3 by inhibiting miR-17-5p. Yes In vitro assays showed that proliferative, migratory, and invasive capacities of esophageal cancer cells were significantly enhanced by circAKT3 overexpression. In vivo assays showed circAKT3 knockdown inhibited growth of esophageal cancer. 33519139 AKT1 CircRNA Homo sapiens Uterine Cervical Neoplasms CC samples and cell lines regulation[circ-AKT1/miR-942-5p/AKT1 axis] colony Formation Assay//RNA Pull-Down//Northern Blot//Western Blot//ISH//qPCR//FISH//RIP//PCR//IP//Colony Formation Assay//IF We discovered the new circRNA, circ-0033550, upregulated in CC. Its associated gene was AKT (also known as protein kinase B) serine/threonine kinase 1 (AKT1), so we renamed circ-0033550 as circ-AKT1.Mechanically, we illustrated that circ-AKT1 upregulated AKT1 by sponging miR-942-5p. Rescue assays confirmed the role of the circ-AKT1/miR-942-5p/AKT1 axis in CC progression. Yes Functionally, gain- and loss-of-function experiments indicated that circ-AKT1 and AKT1 promoted CC cell proliferation and invasion. 32193155 AK137033 LncRNA Rattus norvegicus Diabetic Osteoporosis ASCs Interaction(Wnt signaling pathway via DNA methylation) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//IF Compared with CON-ASCs, AK137033 expression, the DNA methylation level of the sFrp2 promoter region, Wnt signaling pathway markers, and the osteogenic differentiation potential were decreased in DOP-ASCs. In vitro experiments showed that AK137033 silencing inhibited the Wnt signaling pathway and osteogenic ability of CON-ASCs by reducing the DNA methylation level in the sFrp2 promoter region. Additionally, overexpression of AK137033 in DOP-ASCs rescued these changes caused by DOP. Moreover, the same results were obtained in vivo. Yes AK137033 small interfering RNA (SiRNA) and an AK137033 overexpression plasmid were used to regulate the expression of AK137033 in CON-ASCs and DOP-ASCs in vitro. Lentiviruses that carried shRNA-AK137033 or AK137033 cDNA were used to knockdown or overexpress AK137033, respectively, in CON-ASCs and DOP-ASCs in vivo.Compared with CON-ASCs, AK137033 expression, the DNA methylation level of the sFrp2 promoter region, Wnt signaling pathway markers, and the osteogenic differentiation potential were decreased in DOP-ASCs. 34953002 AK136714 LncRNA Homo sapiens Atherosclerosis the plaque and plasma of the atherosclerosis patients Interaction(HuR/ TNF-α, IL-1β and IL-6 ) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//PCR//H&E Staining Compared with the healthy group, lncRNA AK136714 expression was elevated in the plaque and plasma of the atherosclerosis patients in a GEO dataset. Moreover, AK136714 was found to bind directly to HuR to increase the mRNA stability of TNF-α, IL-1β and IL-6 mRNAs. In addition, AK136714 promoted the transcription of Bim. Yes AK136714 silencing inhibited atherosclerosis formation in ApoE-/- mice. AK136714 silencing also protected the endothelial barrier and inhibited endothelial cell inflammation. In vitro assays showed that knockdown of AK136714 suppressed the inflammatory response and apoptosis in human umbilical vein endothelial cells (HUVECs). 34015766 AK093407 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissue and cells Expression(highly expressed) Flow Cytometry//qRT-PCR//MTT//Western Blot The results showed that the expression of AK093407 in human colon cancer tissue was higher than in para-carcinoma tissue. The amount of AK093407 in HCT-15 and HCT-116 cells was higher than that in normal colorectal epithelial NM460 cells. Yes When AK093407 was silenced, the proliferation of HCT-15 and HCT-116 cells decreased, the apoptosis rate increased, the cell cycle was arrested in the G1/S phase, the expression of caspase-3, caspase-8, caspase-9, bax, cyclin-A1, cyclin- B1, p21, p27 increased, and the expression of bcl-2, cyclin-D1, cyclin-E1, p-Stat3 decreased. 35400339 AK006774 LncRNA Homo sapiens Myocardial Reperfusion infarct area Interaction(miR-448/bcl-2 signaling axis) In Vivo Experiment//RNA Pull-Down//Tunel//Flow Cytometry//qRT-PCR//Luciferase Report Assay We first found that AK006774 overexpression reduced I/R-induced infarct area and cardiomyocyte apoptosis in vivo. Accordingly, AK006774 inhibited apoptosis and oxidative stress in cardiomyocytes subjected to H/R treatment in vitro. Mechanistically, AK006774 modulated the expression of bcl-2 by sponging miR-448. Overexpression of miR-448 antagonized the effects of AK006774 on cardiomyocyte apoptosis. Yes We first found that AK006774 overexpression reduced I/R-induced infarct area and cardiomyocyte apoptosis in vivo. Accordingly, AK006774 inhibited apoptosis and oxidative stress in cardiomyocytes subjected to H/R treatment in vitro. 34369259 AK087124 LncRNA Mus musculus Atherosclerosis plasma and plaque from atherosclerotic mice Interaction(miR-224-5p/PTEN axis) RNA Pull-Down//Western Blot//Transfection//qPCR//Luciferase Report Assay//ELISA We investigated the roles of lncRNA AK087124 and miR-224-5p in atherosclerotic pathogenesis and found that AK087124 was up-regulated while miR-224-5p was down-regulated in in the plasma and plaque from atherosclerotic mice compared with normal mice. Bioinformatic prediction combining with luciferase assays indicated that AK087124 could sponge miR-224-5p and enhance the PTEN expression which is a target of miR-224-5p.RNA pull down assays also showed that biotin-miR-224-5p probe could interacted directly with AK087124 and PTEN. Yes The function study indicated that knockdown of AK087124 inhibited ox-LDL induced endothelial apoptosis and inflammatory response. 33974917 AK077216 LncRNA Homo sapiens colorectal adenocarcinoma CRA tissues Interaction(miR-34a) qRT-PCR//Transwell Assay AK077216 was downregulated in CRA tissues compared to that in non-tumor tissues of CRA patients. MiR-34a was upregulated in CRA tissues and inversely correlated with AK077216. Overexpression of AK077216 decreased the expression levels of miR-34a, while overexpression of miR-34a did not affect the expression of AK077216. During a 5-year follow-up, patients with lower expression levels of AK077216 in CRA tissues showed significantly lower overall survival. Yes Overexpression of AK077216 inhibited CRA cell migration and invasion, while overexpression of miR-34a accelerated cancer cell migration and invasion and attenuated the effects of overexpression on AK077216 on cell behaviors. 35484046 AK058003 LncRNA Homo sapiens esophageal carcinoma EC tissues Expression[highly expressed] qRT-PCR//Wound Healing Assay LncRNA AK058003 was highly expressed EC tissues compared with para-carcinoma tissues (p<0.01). Yes LncRNA AK058003 is highly expressed in EC patients, which promotes proliferation, migration, invasion, and metastasis of EC cells. 32495875 AK035396 LncRNA Homo sapiens Myocardial Reperfusion Injury MIRI models Interaction(Mterf1) In Vivo Experiment//RNA Pull-Down//Western Blot//Tunel//qRT-PCR//Cell Apoptosis Assay In vivo and in vitro MIRI models, AK035396 was up-regulated after myocardial infarction. AK035396 directly interacts with Mterf1 and inhibits the level of Mterf1. Further experiments have shown that inhibiting Mterf1 will promote the expression of mitochondrial genes COXII and CYTb and cause cell apoptosis. Yes Functional studies have shown that knockdown of AK035396 reduces the apoptosis of primary cardiomyocytes and mouse myocardial tissue. 34820386 AK027294 LncRNA Homo sapiens Stomach Neoplasms GC tissue,cell lines Interaction[upregulating PCNA] qRT-PCR//MTT//EdU Staining AK027294 expression level was significantly higher in GC tissue samples and cell lines.Furthermore, the expression of PCNA was downregulated via silence of AK027294 in GC cells, while the expression of PCNA was upregulated via overexpression of AK027294 in GC cells. The correlation analysis showed that PCNA expression was positively correlated with AK027294 expression in GC tissues. Yes Results of MTT assay, colony formation assay, and EdU incorporation assay showed that cell proliferation was inhibited through the silence of AK027294 in GC cells, while cell proliferation was promoted through overexpression of AK027294 in GC cells. 31298327 AK025387 LncRNA Homo sapiens Stomach Neoplasms Gastric Cancer tissues Expression[highly expressed] qRT-PCR In this research, we identify one kind of lncRNA, called AK025387, which is highly expressed in metastatic gastric cancer samples compared with non-metastatic gastric cancer samples. The expression of AK025387 is significantly positively correlated with lymph node metastasis. Yes The in situ hybridization demonstrates that AK025387 is located in both nucleus and cytoplasm, but mostly in cytoplasm. AK025387 promotes gastric cancer cells migratory and invasive ability, but it inhibits apoptosis in vitro. 32509569 AK024094 LncRNA Homo sapiens Breast Neoplasms BCa tissues and cell lines regulation[miRNA-181a] qRT-PCR//Luciferase Report Assay AK024094 was significantly upregulated in BCa tissues and cell lines. In addition, AK024094 accelerates the proliferation and metastasis of BCa cells by targeting miRNA-181a. Meanwhile, the rate of distant metastasis was significantly higher, and the overall survival was shorter in BCa patients with high expression of AK024094. Yes The knockdown of AK024094 significantly attenuated the proliferative, migratory, and invasive abilities of MDA-MB-468 and MCF-7 cells. 32141560 AK021443 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Expression [highly expressed] qRT-PCR AK021443 expression was increased in HCC tissues and cell lines. However, these functions could be reversed by overexpression of AK021443. AK021443 significantly controlled HepG2 and Bel-7402 cell proliferation, colony formation, invasion, and migration by repressing EMT, which might provide a potential therapeutic target for HCC diagnosis. Yes Knockdown of AK021443 significantly reduced HepG2 and Bel-7402 cell proliferation, invasion, and migration. Furthermore, inhibition of AK021443 in HepG2 and Bel-7402 cells significantly repressed EMT ability. Knockdown of AK021443 in vivo also significantly inhibited tumor growth with decreased Ki-67 levels and EMT phenotype in tumor tissues. 29638164 ADAMTS9-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction(PI3K/AKT/mTOR signaling pathway) Flow Cytometry//qRT-PCR In this study, we detected that ADAMTS9-AS1 is highly expressed in bladder cancer. Interestingly, the up-regulation of ADAMTS9-AS1 was accompanied by the activation of PI3K/AKT/mTOR signaling pathway, while the down-regulation of ADAMTS9-AS1 lead to an opposite effect. Yes We observed that the up-regulation of ADAMTS9-AS1 promoted cell proliferation, migration and invasion, and reduced the apoptosis and autophagy of 5637 and T42 cell lines. Meanwhile, the down-regulation of ADAMTS9-AS1 increased the apoptosis and autophagy, and suppressed their proliferation, migration and invasion. 34428588 ADAMTS9-AS1 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-128 and miR-150/Ras/MAPK and Wnt pathways) Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay Then, RT-qPCR verified the upregulation of ADAMTS9-AS1 in glioma tissues and cell lines. Furthermore, dual-luciferase assay supported that cytoplasmic ADAMTS9-AS1 is capable of sponging miR-128 and miR-150, which are known as regulators of Ras/MAPK, PI3K, and Wnt pathways. Overall, these results introduced ADAMTS9-AS1 as an oncogene that upregulates Ras/MAPK and Wnt pathways through sponging of the miR-128 and miR-150 in glioma cells. Yes Finally following the ADAMTS9-AS1 overexpression, upregulation of Ras/MAPK and Wnt signaling pathways was verified through western blotting and Top/Fop flash assay, respectively. At the cellular level, ADAMTS9-AS1 overexpression brought about reduced sub-G1 cell population, increased proliferation rate, reduced apoptosis level, increased migration rate, shortened Bax/Bcl2 ratio, induced EMT, and stemness characteristics of transfected cells, detected by flow cytometry, MTT assay, scratch test, and RT-qPCR. 36449154 CBR3-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma cells and tissues Interaction(miR-140-5p/DDX54-NUCKS1-mTOR signaling pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Co-IP//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay The obtained data showed that CBR3-AS1 demonstrated a high expression in osteosarcoma cells. Mechanically, CBR3-AS1 sponged miR-140-5p and recruited DDX54 to upregulate NUCKS1, thus activating the mTOR signaling pathway. Yes CBR3-AS1 could promote stemness and EMT of osteosarcoma cells as well as osteosarcoma tumor growth. 35592388 circEIF4G3 CircRNA Homo sapiens Stomach Neoplasms GC tissues Interaction[sponging miR-335 ] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//FISH A total of 3 hepatocellular carcinoma (HCC) tissues and their matched non-cancerous tissues were collected and screened for dysregulated circRNA using human circRNA microarray and the result showed circ-EIF4G3 was significantly up-regulated in hepatocellular carcinoma. Our study demonstrates that circ-EIF4G3 promotes the proliferation, invasion and migration of gastric cancer via sponging miR-335. An increase level in the circ-EIF4G3 expression was associated with higher TNM stage and lymphatic metastasis. Yes In vitro assays of the GC cell lines AGS and BGC-823 demonstrated that knockdown of circ-EIF4G3 inhibited cell proliferation, invasion and migration significantly. 31257089 hsa_circ_0001829 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-155-5p/SMAD2 axis] ISH//qRT-PCR We found that hsa_circ_0001829 was significantly upregulated in GC tissues and cell lines. Taken together, our findings firstly demonstrated a novel oncogenic role of hsa_circ_0001829 in GC progression through miR-155-5p-SMAD2 axis, and our study may offer novel biomarkers and therapeutic targets for GC. Yes Loss- and gain-of- function assays showed that hsa_circ_0001829 promotes GC cells proliferation, migration and invasion, and the affected cell cycle progression and apoptosis rates may account for the effect of hsa_circ_0001829 on GC proliferation. 33308284 circB3GNTL1 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cell lines regulation[miR-598] Flow Cytometry//qRT-PCR The results showed that CircB3GNTL1 expression was up-regulated and miR-598 expression was up-regulated in gastric cancer tissues and cell lines;It was concluded that CirB3GNTL1 prevents decomposition of glutamines and induces apoptosis by controlling miR-598 in gastric cancer cells. Yes Knockdown circB3GNTL1 prevented proliferation and glutamine decomposition of the gastric cancer cells and induced apoptosis compared with normal para-cancers and gastric cancer cell lines. 33287917 circASAP2 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cell lines regulation[miR-770-5p/CDK6 axis] qRT-PCR//MTT//Transwell Assay The expression levels of circ_ASAP2 and CDK6 were increased, and miR-770-5p level was decreased in GC tissues and cells.Circ_ASAP2 knockdown can repress the development of GC cells partly through regulating the miR-770-5p/CDK6 axis, suggesting an underlying circRNA-targeted therapy for GC treatment. Yes Furthermore, circ_ASAP2 knockdown inhibited cell viability, migration, and invasion of GC cells. 33284890 hsa_circ_100876 CircRNA Homo sapiens Stomach Neoplasms GC tissues regulation[miR-665/YAP1 Signaling] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Our study confirmed that circRNA_100876 was highly expressed in GC lesions compared with the adjacent normal tissues (P < 0.001).Therefore, we demonstrated that circRNA_100876 over-expression in GC could promote GC tumor growth, migration and invasion and exert its effects through miR-665/YAP1 signaling. High circRNA_100876 expression was negatively associated with survival outcome (P = 0.000). Yes Furthermore, the down-regulation of circRNA_100876 could inhibit GC cell proliferation, invasion, and migration by suppressing the EMT pathway. 33262782 circCUL3 CircRNA Homo sapiens Stomach Neoplasms Gastric Cancer tissues,cell lines regulation[STAT3/HK2 Axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//ChIP High-regulated expression of circCUL3 was observed in both GC tissues and cell lines. In summary, the present findings provide mechanistic insights into circCUL3/miR-515-5p/STAT3/HK2 axis regulation on the GC Warburg effect, providing a novel possibility for an understanding of GC pathogenesis. Clinically, the high expression of circCUL3 was closely correlated with advanced clinical stage and overall survival in GC patients. Yes Functionally, cellular experimental investigations demonstrated that circCUL3 promoted the proliferation, glucose consumption, lactate production, ATP quantity, and extracellular acidification rate (ECAR) of GC cells. In vivo, circCUL3 knockdown repressed tumor growth. 33230436 circPRRX1 CircRNA Homo sapiens Stomach Neoplasms GC tissues, cell lines regulation[MicroRNA-665/YWHAZ Axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Compared with normal tissues and cells, circ-PRRX1 and YWHAZ levels were upregulated, and miR-665 was downregulated in GC tissues and cells. Circ-PRRX1 knockdown suppressed GC development by targeting miR-665 to inhibit YWHAZ expression, and the potential molecular mechanism may provide a theoretical basis for GC therapy. Yes Functionally, circ-PRRX1 knockdown inhibited the viability, migration, and invasion and promoted apoptosis in GC cells, whereas anti-miR-665 abolished these effects. 33201331 hsa_circ_0004872 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[hsa_circ_0004872/miR-224/Smad4/ADAR1] ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//EdU Staining//Transwell Assay In this study, we found that hsa_circ_0004872 was dramatically downregulated in GC tissues compared with adjacent noncancerous tissues. Our findings showed that hsa_circ_0004872 acted as a tumor suppressor in GC by forming a negative regulatory loop consisting of hsa_circ_0004872/miR-224/Smad4/ADAR1. Thus, hsa_circ_0004872 may serve as a potential biomarker and therapeutic target for GC. The expression level of hsa_circ_0004872 was associated with tumor size and local lymph node metastasis. Yes Enforced expression of hsa_circ_0004872 inhibited the proliferation, invasion and migration of GC cells, whereas knockdown of hsa_circ_0004872 had the opposite effects. Nude mice experiments showed that ectopic expression of hsa_circ_0004872 dramatically inhibited tumor growth and metastasis in vivo. 33172486 circPDZD8 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cells interaction[ sponging miR-197-5p] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay CircPDZD8 was up-regulated in gastric cancer tissues and cells, Kaplan-Meier survival analysis indicated that gastric patients had a poor overall survival when circPDZD8 levels were high. Importantly, circPDZD8 could up-regulate CHD9 expression by sponging miR-197-5p, and modulate cell progression by regulation of the miR-197-5p/CHD9 axis in gastric cancer. CircPDZD8 was up-regulated in gastric cancer tissues and cells, Kaplan-Meier survival analysis indicated that gastric patients had a poor overall survival when circPDZD8 levels were high. Yes CircPDZD8 knockdown could hinder proliferation and migration of gastric cancer cells. 33049714 hsa_circ_0005556 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cell lines regulation[ hsa_circ_0005556/miR-4270/MMP19 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay The expression of hsa_circ_0005556 in gastric cancer tissues and gastric cancer cell lines was higher compared to normal controls. Our study shows that the hsa_circ_0005556/miR-4270/MMP19 axis is involved in proliferation, migration, and invasion of gastric cancer cells through the competing endogenous RNA (ceRNA) mechanism. Yes In vitro, the downregulation of hsa_circ_0005556 significantly inhibited proliferation, migration, and invasion of gastric cancer cells. In vivo, the downregulation of hsa_circ_0005556 suppressed tumor growth in nude mice. 33024586 circC16orf62 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[ miR-421/TUBB2A axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay "Circ_C16orf62 andTUBB2A were downregulated in GC tissues and cells.These findings demonstrate that circ_C16orf62 impeded proliferation, migration, and invasion in vitro and retarded tumor growth in vivo by the miR-421/TUBB2A axis in GC, providing a potential therapeutic strategy for patients with GC. " Yes Circ_C16orf62 was predominantly located in the cytoplasm of GC cells, and repressed proliferation, migration, and invasion of GC cells. 33006960 hsa_circ_001653 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells interaction[binding to microRNA-377] qRT-PCR//Luciferase Report Assay//Western Blot hsa_circ_001653 was found to be an up-regulated circRNA in GC tissues and cells. Collectively, the demonstration that hsa_circ_001653 exerts its anticancer effects by regulating the miR-377-NR6A1 axis increases our understanding of gastric cancer pathophysiology. Yes Down-regulation of hsa_circ_001653 inhibited GC cell proliferation, migration and invasion, while stimulating cell apoptosis. 33006200 circFLNA CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells interaction[as a Sponge of miR-646] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Transwell Assay Our results found that circFLNA was upregulated in GC tissues and cells. Further experiments revealed that circFLNA could sponge miR-646, and miR-646 could target PFKFB2. Yes Silencing of circFLNA could suppress the proliferation, migration, invasion, glycolysis, and enhance the apoptosis of GC cells. Also, circFLNA knockdown reduced GC tumor volume and weight in vivo. 32982406 hsa_circ_100782 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cells interaction[miR-574-3p] CCK8//qRT-PCR//Luciferase Report Assay In the current study, compared with adjacent non-cancerous normal tissues, the expressions of circRNA_100782 and Rb were both downregulated in human gastric cancer cells.In this research, we discovered that circRNA_100782 was downregulated in gastric cancer cells and is associated with cell proliferation and invasion by inhibiting tumor suppressor gene Rb by interacting with miR-574-3p. Yes Through qRT-PCR and CCK-8 assay, we found that the expression of circRNA_100782 is related to the proliferation of gastric cancer cells. Besides, we also found that circRNA_100782 regulated the migration ability of gastric cancer cells through transwell assay. 32964973 circRIMS CircRNA Homo sapiens Stomach Neoplasms Gastric Cancer tissues interaction[hsa-miR-148a-5p and hsa-miR-218-5p] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay We observed that circRIMS expression was markedly upregulated in T3N3M0 GC tissues and significantly correlated with clinical stage in the RNA sequencing data. CircRIMS remarkably promoted GC cell metastasis in vitro, functioning as a sponge for hsa-miR-148a-5p and hsa-miR-218-5p. Yes CircRIMS remarkably promoted GC cell metastasis in vitro, functioning as a sponge for hsa-miR-148a-5p and hsa-miR-218-5p. 32954174 circNHSL1 CircRNA Homo sapiens Stomach Neoplasms GC tissues, and cells,exosomes regulation[miR-149-5p/YWHAZ Axis] RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Transwell Assay CircNHSL1 was highly expressed in GC cell-derived exosomes, GC tissues, and cells. Our studies disclosed that circNHSL1 knockdown repressed migration, invasion, and glutaminolysis in vitro and inhibited tumor growth in vivo by miR-149-5p/YWHAZ axis in GC, implying an underlying circRNA-targeted therapy for GC treatment. Yes Its knockdown impeded GC cell migration, invasion, and glutaminolysis. 32848466 circHIPK3 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[CircHIPK3/miR-876-5p/PIK3R1 axis ] qRT-PCR//MTT//Luciferase Report Assay//Western Blot CircHIPK3 was upregulated in GC tissues and cells compared with controls, and circHIPK3 was more resistance to RNase R than linear homeodomain interacting protein kinase 3 (HIPK3) mRNA.The circHIPK3 mediated the proliferation, migration, invasion, and glutaminolysis of GC cells partly through regulation of miR-876-5p/PIK3R1 axis by the mechanism of competing endogenous RNAs (ceRNA), indicating circHIPK3 was a GC-associated circRNA that promoted GC development. Yes Silencing of circHIPK3 inhibited GC cells proliferation, migration, invasion, and glutaminolysis as well as tumor tumorigenic ability. 32817745 hsa_circ_0000144 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[GPRC5A ,miR-623] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our data indicated that circ_0000144 was up-regulated and miR-623 was down-regulated in GC tissues and cells.Our study indicated that circ-0000144 knockdown repressed GC progression at least partly by regulating GPRC5A expression via sponging miR-623, illumining a novel therapeutic target for GC treatment. Yes Moreover, the knockdown of circ_0000144 weakened GC cell proliferation, colony formation, migration, invasion and glutaminolysis and accelerated cell apoptosis by up-regulating miR-623. Additionally, circ_0000144 depletion inhibited tumor growth in vivo. 32766708 circMRPS35 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues interaction[circMRPS35/KAT7/FOXO1/3a pathway ] RNA Pull-Down//CCK8//qRT-PCR//RNA-seq//Invasion Assay//ChIP Our findings not only reveal the pivotal roles of circMRPS35 in governing histone modification in anticancer treatment, but also advocate for triggering circMRPS35/KAT7/FOXO1/3a pathway to combat gastric cancer. Yes Biologically, circMRPS35 suppresses the proliferation and invasion of gastric cancer cells in vitro and in vivo. 32164722 circDLST CircRNA Homo sapiens Stomach Neoplasms GC tissues Regulation[NRAS/MEK1/ERK1/2 signaling] Western Blot//FISH//RIP//qRT-PCR//Luciferase Report Assay The expression levels of circDLST were dramatically elevated in GC tissues as compared with the adjacent normal tissues, and acted as an independent prognostic factor of poor survival in patients with GC. CircDLST promotes the tumorigenesis and metastasis of GC cells by sponging miR-502-5p to activate the NRAS/MEK1/ERK1/2 signaling. The expression levels of circDLST were dramatically elevated in GC tissues as compared with the adjacent normal tissues, and acted as an independent prognostic factor of poor survival in patients with GC. Yes Knockdown of circDLST inhibited the cell viability, colony formation, DNA synthesis, cell invasion and liver metastasis in vitro and in vivo, whereas overexpression of circDLST had the opposite effects. 30953514 circNHSL1 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[miR-1306-3p/SIX1/vimentin axis] ISH//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We found that the level of circNHSL1 was significantly up-regulated in gastric cancer, and positively correlated with clinicopathological features and poor prognosis of patients with gastric cancer. CircNHSL1 promotes gastric cancer progression through miR-1306-3p/SIX1/Vimentin axis, and may serve as a novel diagnostic marker and target for treatment of gastric cancer patients. We found that the level of circNHSL1 was significantly up-regulated in gastric cancer, and positively correlated with clinicopathological features and poor prognosis of patients with gastric cancer. Yes Functionally, circNHSL1 promoted cell mobility and invasion, as well as in vivo tumorgenesis and metastasis. 31438963 circSPECC1 CircRNA Homo sapiens Stomach Neoplasms cell lines Interaction[KDM4A/YAP1 pathway] RNA Pull-Down//Luciferase Report Assay//RIP This study showed that circ_SPECC1 was down-regulated in various GC cell lines, significantly inhibited GC cell proliferation and invasion, and promote apoptosis, which might play an anti-oncogene role. Circ_SPECC1 was mainly located in the cytoplasm, and its sequence contained multiple potential binding sites of miR-526b. Pull-down experiments with biotinylated miR-526b mimics and circ_SPECC1 probe showed that they could enrich each other. RIP experiments found hat anti-AGO2 antibody could significantly enrich circ_SPECC1. Further dual luciferase reporter gene assay also confirmed that miR-526b could bind directly to circ_SPECC1. miR-526b was also down-regulated in GC cells, and one of its important target genes was KDM4A. Both circ_SPECC1 and miR-526b inhibited the expression of KDM4A and its downstream effector YAP1, but miR-526b inhibitors terminated the above-mentioned inhibition of circ_SPECC1, and KDM4A overexpression reversed the inhibition of circ_SPECC1 and miR-526b on YAP1 expression. Both miR-526b and KDM4A siRNA inhibited GC cell proliferation and invasion, and promote apoptosis; KDM4A overexpression had the opposite effects, and significantly blocked the regulation of miR-526b on cell growth and invasion. Therefore, circ_SPECC1 can enhance miR-526b inhibitory effect on downstream KDM4A/YAP1 pathway by adsorbing it, thus inhibiting GC cell growth and invasion. These findings enrich the mechanism of circRNAs in GC and will provide more new targets for the prevention and treatment of GC. Yes This study showed that circ_SPECC1 was down-regulated in various GC cell lines, significantly inhibited GC cell proliferation and invasion, and promote apoptosis, which might play an anti-oncogene role. 31349968 circHECTD1 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[targeting miR-1256 and activating β-catenin/c-Myc signaling] Western Blot//CCK8//qRT-PCR//FISH//RIP//RNA-seq//Luciferase Report Assay//Transwell Assay In this study, we showed that circHECTD1 expression was markedly upregulated in gastric cancer (GC) and was associated with lymph node metastasis and American Joint Committee on Cancer stage.Dual-luciferase and RNA immunoprecipitation assays demonstrated that miR-1256 was a direct downstream target of circHECTD1. circHECTD1 targeted miR-1256 and subsequently increased the expression level of USP5. The circHECTD1/miR-1256/USP5 axis exerted its tumor-promoting effects by activating the downstream β-catenin/c-Myc signaling pathway. In vivo mouse models further verified the oncogenic roles of circHECTD1 in GC. In this study, we showed that circHECTD1 expression was markedly upregulated in gastric cancer (GC) and was associated with lymph node metastasis and American Joint Committee on Cancer stage. The circHECTD1 expression level was found to be an independent prognostic factor for GC patients. Yes circHECTD1 knockdown inhibited GC cell glutaminolysis, proliferation, migration, and invasion, whereas circHECTD1 overexpression promoted GC progression. 31371702 hsa_circ_0000144 CircRNA Homo sapiens Stomach Neoplasms cell lines Expression[highly expressed] CCK8//qRT-PCR//Transwell Assay Hsa_circ_0000144 was highly expressed in GSE78902 samples from the GEO database (Fig. 5a). To further verify the results, we chose two cell lines and found that the expression of hsa_circ_0000144 was upregulated in MGC-803 GC cancer cells lines compared to GES-1 normal cells (Fig. 5b). Yes Hsa_circ_0000144 knockdown suppressed tumor growth in vitro. 31636511 circERBB2 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Interaction[miR-503/CACUL1 and miR-637/MMP-19 signaling] CCK8//qRT-PCR//Invasion Assay//Transwell Assay We found circ-ERBB2 was strikingly increased in GC tissues and cells. We further predicted and identified circ-ERBB2 sponged miR-503 and miR-637 by bioinformatics analysis and luciferase reporter system. CACUL1 and MMP-19 were then predicted and confirmed as the target of miR-503 and miR-637, respectively. Furthermore, rescue assays indicated that circ-ERBB2 promoted tumor growth and invasion via miR-503/CACUL1 and miR-637/MMP-19 pathways, respectively. Noticeably, circ-ERBB2 upregulation in tumorous tissues was linked to patients' tumor size, depth of invasion, and overall survival. Yes A series of gain and loss-of-function assays indicated its oncogenic role in GC cells, including cell proliferation, apoptosis, migration and invasion. 30853181 circCOL6A3 CircRNA Homo sapiens Stomach Neoplasms cell lines Interaction[miR-3064-5p] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Both circCOL6A3 and COL6A3 were highly expressed in GC cells, while miR-3064-5p was down-regulated. CircCOL6A3 regulated the expression of miR-3064-5p, and the effect of si-circCOL6A3 on cell biological behaviors was abolished by miR-3064-5p inhibitor. MicroRNA-3064-5p targets COL6A3 to regulate its expression. Yes Depleted circCOL6A3 significantly decreased cell viability and mobility, and increased cell apoptosis.. Taken together, the present study indicated that overexpressed circCOL6A3 promoted cell proliferation, migration and apoptosis of gastric cancer through rescission of miR-3064-5p-induced inhibitory effect on COL6A3. 31122696 hsa_circ_0000467 CircRNA Homo sapiens Stomach Neoplasms GC tissues,cell lines,blood Expression[highly expressed] qRT-PCR Hsa_circ_0000467 was significantly upregulated in GC tissue compared to adjacent nontumor tissue (n = 51, P < 0.05). Similar results were detected in the HGC-27, MGC-803, AGS, NUGC-3, GES-1 cell lines (n = 15, P < 0.001), and in the plasma samples from GC patients (n = 20, P < 0.05). Moreover, the hsa_circ_0000467 expression level is closely associated with TNM stage. Additionally, Cox multivariate analysis showed that hsa_circ_0000467 is a novel independent prognostic factor. Yes Furthermore, in vitro experiments demonstrated that knockdown of hsa_circ_0000467 markedly inhibited the proliferation, migration, and invasion of GC cells. Moreover, hsa_circ_0000467 silencing increased tumor apoptosis in vitro. 30461077 hsa_circ_006100 CircRNA Homo sapiens Stomach Neoplasms cell lines Interaction[miR-195/GPRC5A signalling] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay An upregulated hsa_circ_006100 level and downregulated miR‐195 level were found in all four GC cell lines (Figure ​(Figure3A).3A). Forced hsa_circ_006100 expression promoted the migration and invasion of MGC-803 and AGS cells, while those activities were inhibited by miR-195. Mechanistically, GPRC5A was predicted as a target of miR-195 and was upregulated in gastric cancer. A miR-195 inhibitor restored cell viability, proliferation, migration and invasion, and repressed apoptosis via GPRC5A. In vivo studies showed that knockdown of hsa_circ_006100 delayed tumour growth, reduced PCNA expression and upregulated miR-195 and BCL-2 expression which was restored by miR-195 inhibition due to GPRC5A/EGFR signalling, and changed the EMT phenotype in vivo. Patients with a high hsa_circ_006100 level or low miR-195 level had tumours with a high TNM stage, poor cellular differentiation and lymph node metastasis. miR-195 was targeted and inhibited by hsa_circ_006100. Yes Overexpression of hsa_circ_006100 enhanced cellular viability and proliferation, while miR-195 suppressed hsa_circ_006100-enhanced cell growth and induced apoptosis in MGC-803 and AGS cells. In vivo studies showed that knockdown of hsa_circ_006100 delayed tumour growth 31318114 circHIPK3 CircRNA Homo sapiens Stomach Neoplasms GC tissues,cell lines Interaction[Wnt/β-catenin pathway] CCK8//qRT-PCR//Wound Healing Assay//Colony Formation Assay CircHIPK3 level was higher in GC tissues relative to paracancerous tissues.Identically, its level was higher in GC cells compared with that of GES cells.CircHIPK3 promotes GC cells to proliferate and migrate by regulating the Wnt/β-catenin pathway. Upregulation of circHIPK3 indicates poor prognosis of GC patients. The expression level of circHIPK3 was negatively correlated to the overall survival of GC patients. Yes Silence of circHIPK3 weakened proliferative and migratory abilities of GC cells. 31599413 hsa_circ_101882 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Regulation[EMT signaling pathway] Migration Assay//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Invasion Assay Hsa_circ_101882 expression levels were significantly increased in GC tissue and GC cell lines. Mechanically, the dysregulated expression of hsa_circ_101882 affects EMT signaling pathway, which was examined by detecting E-cadherin, N-cadherin, vimentin, and Snail expression levels. Yes Functionally, low expression of hsa_circ_101882 revealed anti-tumor effects via inhibiting cell growth, migration, and invasion and promoting cell apoptosis. 31420917 hsa_circ_0000291 CircRNA Homo sapiens Stomach Neoplasms cell lines Regulation[ miR-183/ITGB1 Axis] qRT-PCR//Luciferase Report Assay//Western Blot Our data showed that hsa_circ_0000291 was upregulated in GC cell lines.Taken together, hsa_circ_0000291 knockdown inhibited GC cell metastasis and growth by regulating the miR-183/ITGB1 axis. Yes Our data showed that hsa_circ_0000291 was upregulated in GC cell lines, whereas hsa_circ_0000291 silencing suppressed cell metastasis and proliferation in in vivo and in vitro studies. 31814763 circSMARCA5 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Expression[lower expressed] CCK8//qRT-PCR//Transwell Assay The circSMARCA5 level was decreased in GC tissues and cell lines. The low expression level of circSMARCA5 was correlated to poorer overall survival and disease-free survival. Low circSMARCA5 expression was revealed as an independent unfavorable predictive factor for GC. Yes Upregulation of circSMARCA5 dampened the proliferation, migration, and invasion of GC cells, whereas circSMARCA5 knockdown promoted GC progression. 30956729 circPRKCI CircRNA Homo sapiens Stomach Neoplasms GC tissues,cell lines Interaction[binding to microRNA-545] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ-PRKCI was significantly highly expressed in GC tissues, as well as cell lines. These results indicated that circ-PRKCI might promote the development of GC by adsorbing microRNA-545 in a sponge manner. High expression of circ-PRKCI was positively associated with a poor prognosis of GC patients. Yes Overexpression of circ-PRKCI significantly promoted the proliferation and invasion of GC cells, whereas reduced the proportion of apoptotic GC cells. 31773680 circPRMT5 CircRNA Homo sapiens Stomach Neoplasms GC tissues Regulation[circ-PRMT5/miR-145/miR-1304/MYC axis] qRT-PCR//Luciferase Report Assay Circ-PRMT5 expression was significantly higher in GC than in adjacent normal tissues, and GC patients with circ-PRMT5 high expression had shorter survival times. High circ-PRMT5 expression may provide a poor prognostic indicator of survival in GC patients and targeting circ-PRMT5/miR-145/miR-1304/MYC axis may be a novel therapeutic strategy for GC. Circ-PRMT5 expression was significantly higher in GC than in adjacent normal tissues, and GC patients with circ-PRMT5 high expression had shorter survival times. Yes Functionally, circ-PRMT5 silence inhibited GC cell growth and invasion. 31701767 circZNF609 CircRNA Homo sapiens Stomach Neoplasms GC tissues Interaction[inhibiting miRNA-145-5p] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay QRT-PCR data revealed a higher level of circ-ZNF609 in GC tissues relative to ANT. Circ-ZNF609 promotes proliferative and invasive abilities of gastric cancer cells by inhibiting miRNA-145-5p expression as a ceRNA, thus accelerating gastric cancer progression. Yes The knockdown of circ-ZNF609 in BGC823 and MGC803 cells suppressed proliferative and invasive abilities. 31773689 circLMTK2 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[miR-150-5p/c-Myc axis] qRT-PCR//Luciferase Report Assay//Western Blot circLMTK2 was frequently upregulated in GC tissues.Our findings demonstrate that circLMTK2 functions as a tumour promoter in GC through the miR-150-5p/c-Myc axis and could thus be a prognostic predictor and therapeutic target for GC. circLMTK2 was frequently upregulated in GC tissues, and high circLMTK2 expression was associated with poor prognosis, lymph node metastasis and poor TNM stage in GC patients. Yes Functionally, circLMTK2 overexpression promoted GC cell proliferation and tumourigenicity in vitro and in vivo. 31722712 circRBMS3 CircRNA Homo sapiens Stomach Neoplasms GC tissues Regulation[miR-153-SNAI1 axis] qRT-PCR//Microarray In the current study, high throughput microarray assay showed that circRBMS3 was upregulated in GC tissues, which was further confirmed by quantitative reverse transcription polymerase chain reaction. Collectively, these results suggested that circRBMS3 promoted GC cells proliferation and invasion via regulating miR-153/SNAI1 axis. Correlation analysis revealed that high circRBMS3 expression was associated with advanced TNM stage, depth of invasion, and lymph-node metastasis. Kaplan-Meier analysis indicated that GC patients with high circRBMS3 expression have a poor overall survival (OS). Yes Function assays showed that circRBMS3 silencing reduced GC cells proliferation and invasion in vitro, and inhibited the tumor growth in vivo. 30132886 circDB CircRNA Homo sapiens Stomach Neoplasms GCa tissues Interaction[binding microRNA-34a] qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay The expression of circ-DB and MET in GCa tissues was significantly higher than that in the corresponding adjacent tissues. Circ-DB may regulate MET level through microRNA-34a and affect the proliferative ability and migration of GCa cells. Yes In vitro cell experiments showed that low expression of circ-DB inhibited cell migration, which could be recovered by the co-transfection with microRNA-34a inhibitor. 31799656 circDUSP16 CircRNA Homo sapiens Stomach Neoplasms Interaction[sponging miR-145-5p] Western Blot//FISH//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression levels of circDUSP16 were markedly increased in GC tissue samples and acted as an independent prognostic factor of poor survival in patients with GC. CircDUSP16 facilitates the tumorigenesis and invasion of GC cells by sponging miR-145-5p, and may provide a novel therapeutic target for GC. The expression levels of circDUSP16 were markedly increased in GC tissue samples and acted as an independent prognostic factor of poor survival in patients with GC. Yes Knockdown of circDUSP16 repressed the cell viability, colony formation, and invasive potential in vitro and in vivo, but ectopic expression of circDUSP16 reversed these effects. 31776711 hsa_circ_0000190 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cells regulation[miR-1252/PAK3 pathway] qRT-PCR//Luciferase Report Assay//FISH Circ_0000190 was down-regulated in gastric cancer tissues and cells, with a major location in cytoplasm.Circ_0000190 suppresses gastric cancer progression potentially via inhibiting miR-1252/PAK3 pathway, employing circ_0000190 might be a promising therapeutic strategy for the treatment of gastric cancer. Yes Circ_0000190 inhibited gastric cancer cell viability, proliferation and migration, and induced apoptosis and cell cycle arrest by regulating the expression of capase-3, p27 and cyclin D. 32742198 hsa_circ_0005556 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[miR-767-5p] circRIP//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The upregulation of circ_0005556 was validated by qRT-PCR in GC tissues and cells, and a higher circ_0005556 level indicated a poorer prognosis.The in vitro knockdown of circ_0005556 remarkably repressed GC cell progression by increasing the expression of miR-767-5p. The upregulation of circ_0005556 was validated by qRT-PCR in GC tissues and cells, and a higher circ_0005556 level indicated a poorer prognosis. Yes Knockdown of circ_0005556 was revealed to repress GC cell viability, invasion, and migration and to promote GC cell apoptosis. 32728015 ADAMTS9-AS1 LncRNA Homo sapiens Prostatic Neoplasms Pca tissues Interaction(miR-142-5p/CCND1 axis) qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Bioinformatics Analysis ADAMTS9-AS1 expression is down-regulated in PCa. Importantly, microRNA-142-5p (miR-142-5p) mimic and small-interfering RNA targeting cyclin D1 (CCND1, si-CCND1) could attenuate the inhibitory effects of ADAMTS9-AS1 overexpression on PCa cell growth. Yes Forcing ADAMTS9-AS1 expression impedes PCa cell proliferation via initiating cell apoptosis. 33704879 circPIP5K1A CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[CircPIP5K1A/miR-671-5p/KRT80 axis] Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircPIP5K1A was up-regulated in GC tissues and cells with a circular structure.CircPIP5K1A/miR-671-5p/KRT80 axis contributes to GC progression through PI3K/AKT pathway, implying this axis may be a potential therapeutic target for the treatment of GC patients. Yes Functionally, circPIP5K1A silence limited cell proliferation, invasion, migration and EMT process. 32169757 hsa_circ_0005075 CircRNA Homo sapiens Stomach Neoplasms GC tissues,GC cell lines regulation[miR-431/p53/epithelial-mesenchymal transition axis ] Western Blot//CCK8//qRT-PCR//EdU Staining//Transwell Assay Then, our data revealed that CircRNA_0005075 was found to be significantly up-regulated in GC tissues as well as GC cell lines, and the GC patients with higher CircRNA_0005075 expression were more likely to have poor outcomes. Briefly, circRNA_0005075 could directly inhibit the expression level of miR-431, then regulate the p53/Epithelial-mesenchymal transition axis, and finally inhibit cell growth and metastasis in GC. Then, our data revealed that CircRNA_0005075 was found to be significantly up-regulated in GC tissues as well as GC cell lines, and the GC patients with higher CircRNA_0005075 expression were more likely to have poor outcomes. Yes Down-regulation of CircRNA_0005075 could significantly suppress the GC cell proliferation and cell metastasis ability, while the addition of miR-431 inhibitors could counteract this effect. 32133664 circHIPK3 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells interaction[Sponging miR-107,Regulating BDNF] CCK8//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay circHIPK3 was further confirmed to be upregulated in all GC tissues and cells tested. Furthermore, circHIPK3 levels were associated with Tumor & Lymph Node & Metastasis(TNM) stage (P = 0.032). The area under the receiver operating characteristic curve (ROC) was 0.743 (95% confidence interval 0.615-0.872; P = 0.001). Yes CCK-8, colony formation, Transwell and EdU assays were performed to evaluate the effects of circHIPK3 on cell proliferation and migration in GC. 32110057 hsa_circ_0006282 CircRNA Homo sapiens Stomach Neoplasms GC tissues regulation[miR-155,FBXO22] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The expression of circ_0006282 in GC tissues was significantly higher than its adjacent non-cancer tissues and over-expression of circ_0006282 was associated with tumor size, lymph nodes metastasis and TNM stage, but no obvious links with other pathological parameters.Our findings indicated that over-expression of circ_0006282 down‑regulated miR-155 to activate the expression of FBXO22, thus promoting proliferation and metastasis of GC cells, which provides a promising therapeutic target for GC treatment. The expression of circ_0006282 in GC tissues was significantly higher than its adjacent non-cancer tissues and over-expression of circ_0006282 was associated with tumor size, lymph nodes metastasis and TNM stage, but no obvious links with other pathological parameters. Yes Knockdown of circ_0006282 inhibited the proliferation and metastasis ability of GC cells in vitro and suppressed the tumor growth in vivo. 32099403 hsa_circ_0010882 CircRNA Homo sapiens Stomach Neoplasms plasma of GC patients and GC cell lines regulation[PI3K/Akt/mTOR signaling pathway] qRT-PCR//Western Blot We found that hsa_circ_0010882 expression was significantly upregulated in the plasma of GC patients and GC cell lines. It plays an important role in proliferation, migration, and invasive genotypes of GC cell lines via regulation of the PI3K/Akt/mTOR signaling pathway. In addition, GC patients with higher expression of hsa_circ_0010882 had significantly lower overall survival than patients with lower expression of hsa_circ_0010882. Yes The proliferation, migration, and invasiveness of GC cell lines were inhibited following hsa_circ_0010882 knock-down, while GC cellular apoptosis increased. 32096170 circSMAD7 CircRNA Homo sapiens Stomach Neoplasms GC tissues regulation[EMT process] qRT-PCR//Wound Healing Assay//Transwell Assay In this study, RT-qPCR results showed that circ-SMAD7 expression was significantly lower in GC tissues compared to that in adjacent ones.These results indicate that upregulation of circ-SMAD7 inhibits GC cell migration and invasion via reversing the EMT process. Yes Cell migration and invasion of GC were inhibited via upregulation of circ-SMAD7. 32096163 hsa_circ_0000467 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues interaction[Binding to MicroRNA miR-326-3p] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Invasion Assay This study showed that hsa_circ_0000467 expression was higher in gastric cancer tissues than in corresponding adjacent tissues (P < 0.050) and that hsa_circ_0000467 expression levels were correlated with gastric cancer histological grade (P < 0.050). In conclusion, hsa_circ_0000467 plays a regulatory role in the development and progression of gastric cancer by regulating miR-326-3p, and this circRNA may be a potential diagnostic marker and therapeutic target of gastric cancer. Yes Cell function experiments indicated that hsa_circ_0000467 downregulation decreased the proliferation and invasion ability of BGC-823 and SGC-7901 cells and the number of cells entering the G2/M phase. 32090087 circRBM33 CircRNA Homo sapiens Stomach Neoplasms GC specimens and cell lines interaction[targeting miR-149] qRT-PCR//Luciferase Report Assay//RIP CircRBM33 was distinctly upregulated in GC specimens and cell lines and a close correlation between circRBM33 expression and clinical characteristics of GC was observed.Rescue experiments indicated that circRBM33 manipulates biological function in GC cells through the circRBM33/miR-149/IL-6 axis. Yes After silencing circRBM33, the apoptosis of GC cells increased, while proliferation, migration, and invasion decreased. 32044717 hsa_circ_104433 CircRNA Homo sapiens Stomach Neoplasms GC tissues interaction[miR-497-5p] qRT-PCR//Luciferase Report Assay The level of circRNA_104433 showed upregulation in GC tissues, and the expression of it showed a positive correlation with the degree of differentiation and the size of the tumor.CircRNA_104433 directly binds to miR-497-5p, which directly regulates CDC25A. The level of circRNA_104433 showed upregulation in GC tissues, and the expression of it showed a positive correlation with the degree of differentiation and the size of the tumor. Yes Knockdown of circRNA_104433 inhibited cell cycle transition, and cell proliferation, while promoted cell apoptosis in GC. 32021419 circHIAT1 CircRNA Homo sapiens Stomach Neoplasms GC tissues regulation[ miR-21] CCK8//qRT-PCR//Flow Cytometry//Western Blot Our findings demonstrated that circHIAT1 was lowly expressed in GC tissues.CircHIAT1 functioned as a tumor inhibitor in GC cells through downregulating miR-21, and could be a novel target for GC treatment. Yes After transfection with PLCDH-circHIAT1 in MKN28 and MKN45 cells, cell viability was decreased, while the expression levels of p53 and p21 were raised, as well as apoptosis. 32020707 circMAN2B2 CircRNA Homo sapiens Stomach Neoplasms GC tissues regulation[miR-145,PI3K/AKT and JNK pathways] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay As relative to paracancerous tissues, circMAN2B2 was high-expressed in GC tissues. CircMAN2B2 exerted its function possibly through regulating miR-145 as well as PI3K/AKT and JNK pathways. Yes Silence of circMAN2B2 clearly declined SNU-16 and AGS cells viability, survival, migration but enhanced apoptosis. 32020674 circATXN7 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines interaction[miR-4319,ENTPD4] RNA Pull-Down//Tunel//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//EdU Staining//Transwell Assay The results showed an upregulated circATXN7 expression in GC tissues and cell lines.CircATXN7 promoted GC development through sponging miR-4319 and regulating ENTPD4, which identified circATXN7 as a new biomarker in GC. Yes Besides, silenced circATXN7 hampered the proliferation and invasion as well as promoted the apoptosis in GC cells. 31997941 circRHOBTB3 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines interaction[ miR-654-3p] qRT-PCR//RNA Pull-Down//Luciferase Report Assay The expression of circRHOBTB3 was lower in GC tissues and cell lines. Taken together, this study revealed that circRHOBTB3 might function as competing endogenous RNA (ceRNA) for miR-654-3p, which could contribute to growth inhibition of GC through activating p21 signaling pathway. Downregulation of circRHOBTB3 was significantly correlated with poor differentiation and unfavorable prognosis in patients with GC. Yes Overexpression of circRHOBTB3 in GC cells led to decreased proliferation and induced G1/S arrest in vitro, accompanied with inhibited xenograft tumor growth in vivo, while the opposite effects were achieved in circRHOBTB3-silenced cells. 31928527 hsa_circ_102231 CircRNA Homo sapiens Stomach Neoplasms Gastric cancer tissues and plasma Expression [highly expressed] qRT-PCR CircRNA_102231 expression was significantly upregulated in GC tissue and plasma samples, which can be used as a biomarker for GC diagnosis and prognosis. The function assays showed that circRNA_102231 knockdown inhibited GC cell proliferation and invasion both in vitro and in vivo. CircRNA_102231 was able to bind to IRTKS, increasing IRTKS protein stability, leading to GC progression. In sum, our data demonstrate that circRNA_102231 is a novel oncogene in GC and acts as a potential biomarker and therapeutic target for GC patients. high expression of circRNA_102231 was observed more often in patients with larger tumor volume, lymph node metastasis and higher clinical stage. Moreover, Kaplan–Meier plotter showed that GC patients with high circRNA_102231 had shorter survival time than those with low circRNA_102231 Yes The function assays showed that circRNA_102231 knockdown inhibited GC cell proliferation and invasion both in vitro and in vivo. 34374630 circAXIN1 CircRNA Homo sapiens Stomach Neoplasms  GC tumor Expression [highly expressed] Western Blot//Co-IP//Migration Assay//Colony Formation Assay//qRT-PCR//RNA-seq//IHC//Invasion Assay//ChIP "CircAXIN1 is highly expressed in GC tissues compared with its expression in paired adjacent normal gastric tissues. CircAXIN1 overexpression enhances the cell proliferation, migration, and invasion of GC cells, while the knockdown of circAXIN1 inhibits the malignant behaviors of GC cells in vitro and in vivo. Mechanistically, AXIN1-295aa competitively interacts with APC, leading to dysfunction of the ""destruction complex"" of the Wnt pathway." The expression of circAXIN1 is positively associated with lymph node metastasis. Yes CircAXIN1 overexpression enhances the cell proliferation, migration, and invasion of GC cells, while the knockdown of circAXIN1 inhibits the malignant behaviors of GC cells in vitro and in vivo. 34863211 hsa_circ_101996 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction( miR-143) In Vivo Experiment//qRT-PCR//Invasion Assay//ChIP The result showed that hsa_circRNA_101996 expression was significantly upregulated in GC tissues compared to that in the adjacent tissues, and its level in cancer tissue was correlated with tumor size, lymphatic metastasis, and distant metastasis. Compared with the low hsa_circRNA_101996 expression group, the three-year survival rate of patients in the high hsa_circRNA_101996 expression group was significantly lower. and its level in cancer tissue was correlated with tumor size, lymphatic metastasis, and distant metastasis. Compared with the low hsa_circRNA_101996 expression group, the three-year survival rate of patients in the high hsa_circRNA_101996 expression group was significantly lower. Yes The knockdown of hsa_circRNA_101996 dramatically suppressed the cell migration, invasion, and proliferation of GC cells by sponging to absorb miR-143 and elevated the expression of TET2. 34659556 hsa_circ_0009172 CircRNA Homo sapiens Stomach Neoplasms tissues and cell lines Interaction(miR-485-3p/NTRK3 axis) RNA Pull-Down//Luciferase Report Assay The hsa_circRNA_0009172 expression was downregulated in gastric cancer tissues and cell lines, indicating a positive association with patient prognosis. The hsa_circRNA_0009172 expression was downregulated in gastric cancer tissues and cell lines, indicating a positive association with patient prognosis. Yes Functionally, hsa_circ_0009172 overexpression inhibited proliferative, invasive and migrative potential of gastric cancer cells as well as epithelial-mesenchymal transition (EMT)-related proteins by sponging miR-485-3p to inhibit NTRK3, while miR-485-3p overexpression could reverse the inhibitory effect of hsa_circ_0009172 on gastric cancer. Furthermore, either up-regulation of hsa_circ_0009172 or down-regulation of miR-485-3p led to the suppression of xenograft tumor growth in nude mice. 33531648 hsa_circ_0081146 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-144) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay//Transwell Assay Circ_0081146 was upregulated in GC tissues and cells. Patients with high expression of circ_0081146 had a significantly reduced 5-year overall survival rate. Yes Circ_0081146 knockdown restrained the growth, migration and invasion of GC cells in vitro as well as tumorigenesis in vivo. Circ_0081146 targeted miR-144 and HMGB1 was targeted by miR-144. Circ_0081146 was negatively correlated with miR-144 expression, while positively correlated with HMGB1 expression in GC tissues. 33496921 hsa_circ_0000039 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-1292-5p) CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay Circ_0000039 expression was up-regulated in GC tissues and cell lines, and it was significantly related with poor differentiation of tumor tissues. Circ_0000039 expression was up-regulated in GC tissues and cell lines, and it was significantly related with poor differentiation of tumor tissues. Yes In addition, circ_0000039 overexpression enhanced the proliferation, migration and invasion of GC cells, while circ_0000039 depletion inhibited these malignant biological behaviors. In terms of mechanism, it was found that circ_0000039 promoted the proliferation and progression of GC cells by adsorbing miR-1292-5p and up-regulating the expression of DEK. 33104023 hsa_circ_100269 CircRNA Homo sapiens Stomach Neoplasms gastric cancer (GC) samples and cells Interaction(PI3K/Akt axis) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Cell Cycle Assay//Transwell Assay Our findings revealed downregulation of hsa_circRNA_100269 in GC tissues compared to non-cancerous control. Additionally, the levels of PI3K were remarkably elevated in GC tissues, where hsa_circRNA_100269 and PI3K was negatively correlated. Moreover, the expression of hsa_circRNA_100269 was associated with histology grade and occurrence of metastasis in GC patients. Yes In addition, hsa_circRNA_100269 was downregulated in GC cells compared to normal gastric epithelial cells. Overexpressed hsa_circRNA_100269 notably inhibited the proliferation, migration, invasion and EMT of GC cells, whereas cell cycle arrest at G0/G1 phase was promoted and cell apoptosis was enhanced.  33901239 hsa_circ_0032821 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[MEK1/ERK1/2 signaling pathway] CCK8//qRT-PCR//Transwell Assay//Western Blot Circ_0032821 was significantly upregulated in human GC tumors and cells.Circ_0032821 expression induced cell proliferation, EMT, migration, invasion, and autophagy inhibition in human GC cells in vitro and in vivo through activating MEK1/ERK1/2 signaling pathway, suggesting circ_0032821 as an oncogenic role in GC. Moreover, circ_0032821 might be a biomarker for the advanced Tumor node metastasis (TNM) stage, lymphoid node metastasis and poor prognosis in gastric cancer. Yes Knockdown of circ_0032821 by transfection induced decrease of cell proliferation, EMT, migration and invasion, but increase of autophagy of AGS and HGC-27 cells in vitro, as well as induced tumor growth inhibition in vivo. 32165864 hsa_circ_0001649 CircRNA Homo sapiens Stomach Neoplasms GC cells and tissues regulation[miR-20a,ERK and Wnt/β-catenin pathways] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Hsa_circ_0001649 was downregulated in GC cells and tissues.Upregulation of hsa_circ_0001649 restrained GC cell growth and metastasis by downregulating miR-20a and thereby inactivated ERK and Wnt/β-catenin pathways. Yes Upregulation of hsa_circ_0001649 restrained viability, proliferation, migration, and invasion, while promoted apoptosis. 32212290 circKIAA0907 CircRNA Homo sapiens Stomach Neoplasms GC tissue regulation[miR-452-5p/KAT6B Axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Western Blot CircKIAA0907 was downregulated in GC and had higher stability than its linear isoform. This work demonstrated that circKIAA0907 has diagnostic and therapeutic value in GC by acting as an oncogenic molecule via the miR-452-5p/KAT6B axis. Yes Functionally, circKIAA0907 upregulation resulted in the repression of proliferation, cell cycle, and autophagy and promotion of apoptosis in GC cells. 32722658 circCCDC66 CircRNA Homo sapiens Stomach Neoplasms GC tissues regulation[c-Myc and TGF-β signaling pathways] Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Colony Formation Assay//Transwell Assay CircCCDC66 expression was elevated in both GC tissues and cell lines compared to adjacent normal tissues and normal gastric epithelial cell line.CircCCDC66 promotes GC growth and metastasis by activating c-Myc and TGF-β signaling pathways, suggesting that it may serve as a potential biomarker for GC. The upregulation of circCCDC66 in GC tissues was related to tumor stage and lymphatic metastasis. Yes CircCCDC66 knockdown significantly inhibited GC cell proliferation, migration and invasion and induced cell apoptosis in GC cells. 32226494 circREPS2 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[RUNX3/β-catenin Signaling] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP In the present study, we found that circREPS2 was downregulated in GC tissues and cell lines. In conclusion, circREPS2 suppresses the progression of GC via miR-558/RUNX3/β-catenin signaling and is a novel promising biomarker and target for GC treatment. Low expression of circREPS2 was associated with a higher tumor-node-metastasis (TNM) stage, poor tumor differentiation, and larger tumor size in GC patients. Yes Functionally, circREPS2 significantly inhibited GC cell proliferation, migration, invasion, and epithelial-mesenchymal transformation (EMT) in vitro and tumorigenesis in vivo. 32721878 hsa_circ_0081143 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[miR-497-5p/EGFR Axis] qRT-PCR//Luciferase Report Assay//Western Blot//Transwell Assay These data indicated that circ_0081143 expression was increased in GC tissues and cells.The present work suggested that circ_0081143 knockdown ameliorated hypoxia-induced migration, invasion, and EMT in GC cells at least partly by the miR-497-5p/EGFR axis, illuminating a novel molecular target for GC treatment. Yes The knockdown of circ_0081143 relieved hypoxia-induced GC cell migration, invasion, and epithelial/mesenchymal transition (EMT). 32678674 circNRIP1 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-182/ROCK1 Axis] Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay circNRIP1 expression was enhanced in gastric cancer tissues and cells and high expression of circNRIP1 indicated poor survival of patients.Knockdown of circNRIP1 suppressed cell migration and invasion, arrested cell cycle at G0-G1 phase and promoted apoptosis in gastric cancer cells. circNRIP1 expression was enhanced in gastric cancer tissues and cells and high expression of circNRIP1 indicated poor survival of patients. Yes Silence of circNRIP1 inhibited progression of gastric cancer by increasing miR-182 and decreasing ROCK1, providing a novel target for the treatment of gastric cancer. 32636647 hsa_circ_0032627 CircRNA Homo sapiens Stomach Neoplasms cell lines regulation[ miR-502-5p expression] qRT-PCR//Luciferase Report Assay//MTT//Colony Formation Assay Compared with that in gastric mucosal cell lines, the expression level of circ_0032627 was upregulated in the selected four GC cell lines, The expression level of circ_0032627 is raised in GC cells, and circ_0032627 affects the proliferation and apoptosis of GC cells by sponging miR-502-5p. Yes Compared with that in gastric mucosal cell lines, the expression level of circ_0032627 was upregulated in the selected four GC cell lines, and circ_0032627 knockdown substantially inhibited the proliferation of GC cells, but promoted their apoptosis. 32633357 circFGD4 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-532-3p/APC/β-catenin signalling pathway] RNA Pull-Down//ISH//qRT-PCR//RIP//Luciferase Report Assay circFGD4 expression was down-regulated the most in human GC tissues and cell lines. circFGD4 suppressed GC progression through sponging miR-532-3p and enhancing APC expression to inactivate the β-catenin signalling. Low expression of circFGD4 was correlated with poor tumour differentiation, lymphatic metastasis, and poor prognosis of GC patients. Yes circFGD4 suppressed GC cell viability, colony formation, migration, induced epithelial-mesenchymal transition (EMT), and tumorigenesis and metastasis in vivo. 32633323 circHN1 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Expression[highly expressed] qRT-PCR//Luciferase Report Assay//Transwell Assay We found that circHN1 was upregulated in GC tissues and cell lines compared to adjacent non-tumor tissues and normal gastric epithelial cells. Yes Additionally, circHN1 silencing significantly promoted GC cell growth, colony formation, migration, and invasion, whereas circHN1 overexpression had the opposite effects.CircHN1 overexpression also suppressed gastric cancer growth in the mouse xenograft tumor model. 32608539 circSHKBP1 CircRNA Homo sapiens Stomach Neoplasms GC tissues and serum regulation[miR-582-3p/HUR/VEGF pathway] RNA Pull-Down//Western Blot//ISH//qRT-PCR//RIP//Luciferase Report Assay Increased expression of circSHKBP1(hsa_circ_0000936) was revealed in GC tissues and serum and was related to advanced TNM stage and poor survival. Our findings demonstrate that exosomal circSHKBP1 regulates the miR-582-3p/HUR/VEGF pathway, suppresses HSP90 degradation, and promotes GC progression. Increased expression of circSHKBP1(hsa_circ_0000936) was revealed in GC tissues and serum and was related to advanced TNM stage and poor survival. Yes Overexpression of circSHKBP1 promoted GC cell proliferation, migration, invasion and angiogenesis in vitro and in vivo, while suppression of circSHKBP1 plays the opposite role. 32600329 hsa_circ_103809 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells interaction[binding to microRNA-101-3p] qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Transwell Assay Hsa_circ_103809 showed an increased expression both in GCa tissues and cell lines, predicting a poor prognosis of GCa patients. Hsa_circ_103809, highly expressed in GCa, may promote the migration capacity of GCa cells by adsorbing microRNA-101-3p and thus become a new therapeutic target for GCa. Hsa_circ_103809 showed an increased expression both in GCa tissues and cell lines, predicting a poor prognosis of GCa patients. Yes Meanwhile, the invasive and migration capacities of GCa cells were remarkably reduced after the knockdown of hsa_circ_103809. 32572921 hsa_circ_0023642 CircRNA Homo sapiens Stomach Neoplasms GC tissues interaction[sponging microRNA-223] qRT-PCR//RNA Pull-Down The current study showed that hsa_circ_0023642 was upregulated in GC and presented a high positive correlation with the malignant progression of GC. We confirmed that hsa_circ_0023642 could serve as a sponge of miR-223, subsequently promoting GC progression. Yes In addition, in vitro experiments showed that the silencing of hsa_circ_0023642 in GC cell lines MKN-45 and SGC-7901 significantly reduced the proliferation, invasion, and migration of GC cells. 32562304 circRPL15 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-502-3p/OLFM4/STAT3 pathway] qRT-PCR//Luciferase Report Assay//FISH circ-RPL15 was upregulated in GC tissues and cell lines, and the overexpressed circ-RPL15 was correlated with poorer survival of GC patients.circ-RPL15 promotes GC progression and predicts poor prognosis of GC patients, and regulates the malignant phenotypes of GC cells by mediating the miR-502-3p/OLFM4/STAT3 axis. circ-RPL15 was upregulated in GC tissues and cell lines, and the overexpressed circ-RPL15 was correlated with poorer survival of GC patients. Yes Functionally, circ-RPL15 upregulation distinctly promoted the proliferation, migration and invasion of GC cells and inhibited apoptosis. 32559850 hsa-circ-0000670 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell line regulation[microRNA-384/SIX4 axis] Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The expression of hsa-circ-0000670 was determined by RT-qPCR to be highly expressed in gastric cancer tissues relative to corresponding adjacent normal tissues, as well as in gastric cancer cell lines relative to normal gastric mucosal epithelial cell line. Dual-luciferase reporter gene and RIP assays identified the binding of hsa-circ-0000670 to microRNA-384 (miR-384) and the binding of miR-384 to sine oculis-related homeobox 4 (SIX4). Yes Additionally, silencing of SIX4 delayed tumor growth and progression, which were reversed by overexpression of hsa-circ-0000670. 32535033 circCYFIP2 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[miR-1205/E2F1 axis] qRT-PCR circCYFIP2 was found to be significantly upregulated in GC tissues and cell lines. Collectively, our findings suggested that circCYFIP2 might serve as an oncogenic circRNA to promote GC progression via the miR-1205/E2F1 axis, which provided a potential therapeutic target for the treatment of GC. High expression of circCYFIP2 was associated with metastasis and poor prognosis of GC patients. Yes Function assays revealed that overexpression or knockdown of circCYFIP2 significantly enhanced or reduced GC cell proliferation and invasion abilities. 32526476 circMAT2B CircRNA Homo sapiens Stomach Neoplasms GC tissues regulation[miR-515-5p/HIF-1α axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//ChIP Circ-MAT2B was notably increased in GC and could be used as a sensitive and specific indicator of GC diagnosis and prognosis. Circ-MAT2B was notably increased in GC and could be used as a sensitive and specific indicator of GC diagnosis and prognosis. Yes Stable knockdown of circ-MAT2B dramatically inhibited GC cell viability, colony formation, DNA synthesis, glucose uptake and lactate production in vitro, and retarded tumor growth in vivo. 32467667 hsa_circ_000684 CircRNA Homo sapiens Stomach Neoplasms GC cell lines and clinical tissues interaction[microRNA-186 ] qRT-PCR Expression of hsa-circ-000684 and that of ZEB1 mRNA were elevated while microRNA-186 (miR-186) expression was downregulated in GC cell lines and clinical tissues.Collectively, our data show that hsa-circ-000684 reduces the miR-186 expression which leads to an increase in the ZEB1 expression and, consequently, promotion of GC progression. Yes In addition, the effects of hsa-circ-000684 on the proliferation, migration, invasion, and tube formation of GC cells were examined through gain-and loss-of-function experiments. Furthermore, we introduced tumor xenografts into nude mice to better understand these effects in vivo. Either knockdown of hsa-circ-000684 or upregulation of miR-186 inhibited GC cell proliferation, migration, invasion, and tube formation in vitro, and reduced the xenograft tumor growth in nude mice. 32388910 circCCDC9 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-6792-3p/CAV1 axis] RNA Pull-Down//qRT-PCR//RIP//FISH//Luciferase Report Assay Evidently down-regulated expression of circCCDC9 was observed in both GC tissues and cell lines.CircCCDC9 functions as a tumor suppressor in inhibiting the progression of GC through miR-6792-3p/CAV1 axis, which has provided an exploitable biomarker and therapeutic target for patients with GC. Expression of circCCDC9 was negatively correlated with tumor size, lymph node invasion, advanced clinical stage and overall survival in GC patients. Yes Functionally, overexpression of circCCDC9 significantly inhibited the proliferation, migration and invasion of GC cell lines in vitro and tumor growth and metastasis in vivo, whereas miR-6792-3p mimics counteracted these effects. 32386516 hsa_circ_0017639 CircRNA Homo sapiens Stomach Neoplasms GC cell regulation[miR-224-5p/USP3 axis] qRT-PCR//RNA Pull-Down//FISH The data illustrated that in hsa_circ_assays, expression was enhanced in GC cell. Our collective findings advised that hsa_circ_0017639 takes part in GC progression through regulating the miR-224-5p/USP3 axis, highlighting its potential as an effective GC therapeutic target. Yes Downregulation of hsa_circ_0017639 decreased GC cell proliferation and migration in in vitro and in vivo experiments. 32376451 circSMC3 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues regulation[miR-4720-3p/TJP1 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay Using circRNAs microarray, we detected the dysregulated circRNAs and identified an upregulated circRNA, circSMC3 (hsa_circ_0000260), in gastric cancer tissues.Thus, our results indicate that circSMC3 promotes gastric cancer cell proliferation and motility through miR-4720-3p/TJP1. Patients with high circSMC3 expression levels had a poor overall survival via Kaplan-Meier survival analysis implied that gastric cancer. Yes Functionally, loss of circSMC3 abolished the proliferation and motility of gastric cancer cells. 32314520 hsa_circ_100876 CircRNA Homo sapiens Stomach Neoplasms GC tissues interaction[miR-136 and MIEN1] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our data indicated that the expression of circRNA_100876 was raised in GC tissues.Collectively, our data identified that the promotion of GC growth and metastasis induced by circRNA_100876 interacted with miR-136 and MIEN1, indicating an emerging announcement for uncovering the potential mechanism of GC progression. Yes In vitro, functional experiments confirmed that cell proliferation, invasion along with migration was promoted by circRNA_100876 in GC tissues. 32305633 circDONSON CircRNA Homo sapiens Stomach Neoplasms GC tissues Regulation[up-regulated] Northern Blot//ChIP//Transwell Assay//ISH//CCK8//qRT-PCR//Colony Formation Assay//EdU Staining//IF Elevated expression of circ-DONSON was observed in GC tissues and positively associated with advanced TNM stage and unfavorable prognosis.circ-DONSON was localized in the nucleus, recruited the NURF complex to SOX4 promoter and initiated its transcription. Silencing of the NURF complex subunit SNF2L, BPTF or RBBP4 similarly attenuated GC cell growth and increased apoptosis. circ-DONSON knockdown inhibited GC growth in vivo. Yes Silencing of circ-DONSON significantly suppressed the proliferation, migration and invasion of GC cells while promoting apoptosis. 30922402 hsa_circ_0067997 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[inhibition of miR-515-5p] qRT-PCR qRT-PCR was used to validate the expression of circ_0067997 in GC tissues and cell lines. The results revealed that circ_0067997 was upregulated in GC, and high circ_0067997 expression was associated with the poor overall survival rate of GC patients. qRT-PCR was used to validate the expression of circ_0067997 in GC tissues and cell lines. The results revealed that circ_0067997 was upregulated in GC, and high circ_0067997 expression was associated with the poor overall survival rate of GC patients. Yes Knockdown of circ_0067997 significantly reduced cell viability, inhibited colony formation, and attenuated invasive ability, whereas overexpression of circ_0067997 exhibited opposed effects. Circ_0067997 was identified to be a sponge for miR-515-5p directly. 30688097 circHuR CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cell lines Interaction[inhibiting CNBP] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Western Blot Circ-HuR (hsa_circ_0049027) was predominantly detected in the nucleus, and was down-regulated in gastric cancer tissues and cell lines. Mechanistically, circ-HuR interacted with CCHC-type zinc finger nucleic acid binding protein (CNBP), and subsequently restrained its binding to HuR promoter, resulting in down-regulation of HuR and repression of tumor progression. Yes Ectopic expression of circ-HuR suppressed the growth, invasion, and metastasis of gastric cancer cells in vitro and in vivo. 31718709 AC118344.1 LncRNA Homo sapiens Stomach Neoplasms regulation[AC118344.1-AKT2-HK2/MMP2 axis] CCK8//qRT-PCR//Western Blot//Transwell Assay Therefore, our findings provide a novel mechanism of the AC118344.1-AKT2-HK2/MMP2 axis in regulating the development of gastric cancer cells. Yes Upregulating the expression of AC118344.1 induces cell proliferation, invasion in vitro, and lung metastasis in vivo whereas downregulating the expression of AC118344.1 inhibits these effects. 33324106 AC104958.2 LncRNA Homo sapiens Carcinoma, Hepatocellular 65 HCC samples and 30 paired adjacent non-tumor liver tissue Interaction(PCBP2 ) RNA Pull-Down//Western Blot//qRT-PCR//RIP//RNA-seq//Transwell Assay By RNA sequencing (RNA-seq) in a series of 65 HCC samples and 30 paired adjacent non-tumor liver tissue, we identified a novel lncRNA AC104958.2 that was significantly upregulated in HCC tissues and associated with MVI. In addition, the interaction between AC104958.2 and Poly (rC) binding protein 2 (PCBP2) was identified by RNA pull down and mass spectrometry (MS), which was further validated by RNA immunoprecipitation (RIP). PCBP2 was also upregulated in HCC and associated with MVI. High expression of both AC104958.2 and PCBP2 was correlated with tumor size, TNM stage and MVI in HCC. Yes Overexpression of AC104958.2 obviously elevated cell viability, metastasis, invasion and epithelial-mesenchymal transition (EMT), while knockout of AC104958.2 mediated by CRISPR/Cas9 technique showed the opposite effects. 34418457 AC104041.1 LncRNA Homo sapiens head and neck squamous cell carcinoma regulation[Wnt2B/β-catenin pathway] qRT-PCR//Luciferase Report Assay//RIP//FISH In this work, we identified a novel lncRNA AC104041.1 which is highly upregulated and correlated with poor survival in HNSCC patients.Moreover, we demonstrate that salinomycin, which as a highly effective antibiotic in the elimination of cancer stem cells through the Wnt/β-catenin signaling, could enhance the inhibition of tumor growth by antisense oligonucleotides (ASO) targeting AC104041.1 in HNSCC cells and PDXs (patient-derived xenograft) model. In this work, we identified a novel lncRNA AC104041.1 which is highly upregulated and correlated with poor survival in HNSCC patients. Yes Moreover, AC104041.1 overexpression significantly promoted tumor growth and metastasis of HNSCC in vitro and in vivo. 32826863 AC098934 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(METTL3) In Vivo Experiment//Wound Healing Assay//Invasion Assay//CCK8//qRT-PCR//Bioinformatics Analysis//Transwell Assay Compared to the normal tissues, AC098934 was more highly expressed in LUAD tissues.Mechanistically, AC098934 could bind to the m6A antibody and METTL3 protein. METTL3 overexpression promoted the m6A modification on AC098934, thereby increasing the interaction of m6A modification. Yes After AC098934 was knocked down by siRNA, the proliferation, invasion, migration as well as tumorigenesis abilities of both A549 and H1299 cells were reduced. 35711823 AC092839.1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[lower expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 AC092718.4 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Regulation( PI3K-Akt signaling) BrdU//qRT-PCR In this study, we found that AC092718.4 was highly expressed in LUAD and high expression of AC092718.4 was correlated with poor overall survival (OS) and disease-specific survival (DSS) in LUAD.Kyoto Encyclopedia of Genes and Genomes (KEGG) results showed that AC092718.4 was involved in the PI3K-Akt signaling pathway, Th17 cell differentiation, and cell apoptosis. AC092718.4 expression was correlated with immune cell infiltration. In this study, we found that AC092718.4 was highly expressed in LUAD and high expression of AC092718.4 was correlated with poor overall survival (OS) and disease-specific survival (DSS) in LUAD. Yes Finally, we found that the knockdown of AC092718.4 inhibited lung adenocarcinoma (LUAD) cell growth and promote cell apoptosis. 36490353 AC092171.4 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues regulation[microRNA-1271,GRB2] qRT-PCR AC092171.4 was significantly upregulated in HCC tumor tissues compared to normal liver tissues. These findings demonstrate that AC092171.4 promotes growth and progression of HCC by sponging miR-1271 and upregulating GRB2. Yes In vitro cell proliferation, migration and invasiveness were all higher in AC092171.4-overexpressing HCC cells, but lower in AC092171.4-silenced HCC cells, than in controls. Balb/c nude mice injected with AC092171.4-silenced HCC cells had smaller xenograft tumors, which showed less growth and pulmonary metastasis than control tumors. 32692718 AC092127.1 LncRNA Homo sapiens Breast Neoplasms BC cells Interaction(AC092127.1/miR-451a/AEBP2 axis) RNA Pull-Down//Western Blot//In Vitro Experiment//qRT-PCR//RIP//RNA-seq//Luciferase Report Assay//Colony Formation Assay//Transwell Assay MiR-451a was expressed at a low level in BC cells. Overexpression of miR-451a repressed BC cells proliferation, migration and invasion. Moreover, long non-coding RNA AC092127.1 acted as a sponge of miR-451a to enhance the expression level of AE binding protein 2 (AEBP2) that was demonstrated to be the target gene of miR-451a in BC cells. Finally, rescue experiments validated that miR-451a and AEBP2 involved in AC092127.1-mediated BC cell growth, migration and invasion. Yes rescue experiments validated that miR-451a and AEBP2 involved in AC092127.1-mediated BC cell growth, migration and invasion. 34352938 AC087588.2 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(hsa-miR-30a-5p) CCK8//qRT-PCR//migration assay In this study, we found that AC087588.2 was upregulated and associated with a poor prognosis in LUAD. Finally, we constructed a ceRNA network that included hsa-miR-30a-5p and four mRNAs (ANLN, POLR3G, EHBP1, and ERO1A) specific to AC087588.2 in LUAD. The Kaplan-Meier survival analysis showed that lower expression of hsa-miR-30a-5p and higher expression of ANLN, POLR3G, EHBP1, and ERO1A were associated with adverse clinical outcomes in patients with LUAD. Yes Functionally, the knockdown of AC087588.2 restrained LUAD cell proliferation and migration in vitro. 35769906 AC087388.1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression(highly expressed) qRT-PCR//Wound Healing Assay//Colony Formation Assay//Invasion Assay The results demonstrated that the lncRNA SLC16A1-AS1, AC087388.1, and ELFN1-AS1 were significantly overexpressed in the CRC tissues in comparison to their normal counterpart margins. Yes Downregulation of lncRNA AC087388.1 remarkably decreased the cell proliferation and viability of the CRC cells. In addition, the data demonstrated that the downregulation of lncRNA AC087388.1 significantly suppressed cell growth and colony formation capability in the cells. Also, downregulation of lncRNA AC087388.1 attenuated motility and invasion of CRC cells, and significantly decreased the expression of invasion genes. 35193569 AC083843.1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 AC079630.4 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Expression(lower expressed) CCK8//qRT-PCR//Colony Formation Assay//Western Blot AC079630.4 was significantly down-regulated in lung cancer tissues, including in its subtypes. Samples with low AC079630.4 expression had a more advanced pathological stage and a worse prognosis than those with high expression. Yes In experimental validation, AC079630.4 over-expression could significantly inhibit the proliferation and clonality, and up-regulated the receptors of TRAIL (TRAIL-R1 and TRAIL-R2) in lung cancer cells. 34282054 AC079061.1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(VIPR1 axis) qRT-PCR Experimental results suggested that lncRNA-AC079061.1 and VIPR1 were frequently downregulated in HCC cells, while hsa-miR-765 was significantly upregulated. Moreover, the lncRNA-AC079061.1/VIPR1 axis suppressed the proliferation and invasion of HCC cells. Yes Experimental results suggested that lncRNA-AC079061.1 and VIPR1 were frequently downregulated in HCC cells, while hsa-miR-765 was significantly upregulated. Moreover, the lncRNA-AC079061.1/VIPR1 axis suppressed the proliferation and invasion of HCC cells. 36038907 AC073352.1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(YBX1) RNA Pull-Down//Western Blot//ISH//Wound Healing Assay//EdU Staining//Migration Assay//qRT-PCR//FISH//RIP//Cell Viability Assay//Invasion Assay Here we identified a novel lncRNA AC073352.1 that was significantly upregulated in breast cancer tissues and was associated with advanced TNM stages and poor prognosis in breast cancer patients. Collectively, our results demonstrated that AC073352.1 promoted breast cancer metastasis and angiogenesis via binding YBX1, and it could serve as a promising, novel biomarker for prognosis and a therapeutic target in breast cancer. Here we identified a novel lncRNA AC073352.1 that was significantly upregulated in breast cancer tissues and was associated with advanced TNM stages and poor prognosis in breast cancer patients. Yes In addition, AC073352.1 was found to promote the migration and invasion of breast cancer cells in vitro and enhance breast cancer metastasis in vivo. 34218256 AC068039.4 LncRNA Homo sapiens Pulmonary Arterial Hypertension PASMCs Interaction(miR-26a-5p/TRPC6) Western Blot//Transfection//qRT-PCR//migration assay//Luciferase Report Assay//Microarray//Cell Proliferation Assay//Cell Cycle Assay Consistent with microarray analysis, quantitative PCR verified that AC068039.4 was obviously up-regulated in hypoxia-induced PASMCs. Further experiment indicated AC068039.4 promoted hypoxic PASMCs proliferation via sponging miR-26-5p. In addition, transient receptor potential canonical 6 (TRPC6) was confirmed to be a target gene of miR-26a-5p. Yes Knocking down AC068039.4 alleviated proliferation and migration of PASMCs and regulated cell cycle progression through inhibiting cells entering the G0/G1 cell cycle phase. 33026218 AC025180.1 LncRNA Homo sapiens Breast Neoplasms breast tumours Interaction(ITGA2/CCND1 and ACLY) RNA-seq A novel lncRNA (AC025180.1;ENSG00000249899), named herein I2ALR, was identified at the ITGA2 gene locus, and was variably expressed in breast tumours and breast cancer cell subtypes. I2LAR knockdown resulted in upregulation of ITGA2 gene expression, whilst over-expression of I2ALR resulted in downregulation of ITGA2 mRNA. Further, examination of two downstream targets of ITGA2 associated with breast tumor stemness and metastasis (CCND1 and ACLY), revealed concomitant gene expression changes in response to I2ALR modulation. Yes I2LAR knockdown resulted in upregulation of ITGA2 gene expression, whilst over-expression of I2ALR resulted in downregulation of ITGA2 mRNA. Further, examination of two downstream targets of ITGA2 associated with breast tumor stemness and metastasis (CCND1 and ACLY), revealed concomitant gene expression changes in response to I2ALR modulation. 35098437 AC023794.4-201 LncRNA Homo sapiens laryngeal squamous cell carcinoma Expression[lower expressed] Flow Cytometry//qRT-PCR//Transwell Assay In our previous study, it was demonstrated that the expression level of the long non-coding RNA (lncRNA) AC023794.4-201 were decreased in laryngeal squamous cell carcinoma, particularly in cases of LSCC with lymphatic metastasis. In conclusion, the findings of the present study suggested that AC023794.4-201 may exert tumor-suppressive functions in the progression of LSCC and may serve as a potential prognostic biomarker for LSCC. Moreover, low expression levels of AC023794.4-201 were revealed to be an adverse prognostic factor for patients with LSCC. Yes AC023794.4-201 inhibited the proliferation and the cloning capacity of LSCC cells compared with the negative control group as indicated by real-time cell analysis and the plate colony formation assay. 32566004 AC020978 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[PKM2/HIF-1α axis] RNA Pull-Down//Western Blot//Co-IP//qRT-PCR//FISH//RIP//Luciferase Report Assay//ChIP The present study indicated that AC020978 was upregulated in NSCLC, significantly correlated with advanced TNM stage and poor clinical outcomes, representing as an independent prognostic predictor. The present study indicated that AC020978 was upregulated in NSCLC, significantly correlated with advanced TNM stage and poor clinical outcomes, representing as an independent prognostic predictor. Yes Functional assays revealed AC020978's role in promoting cell growth and metabolic reprogramming. 32308748 AC020978 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(MDH2 stability) In Vivo Experiment//RNA Pull-Down//Wound Healing Assay//RIP//FISH//IF//IHC//Transwell Assay In this study, we evaluated the expression levels of AC020978 in a series of NSCLC tissues using FISH assays and found that higher AC020978 expression levels were closely associated with metastasis and unfavorable prognosis. Further investigation demonstrated that AC020978 interacted with malate dehydrogenase 2 (MDH2) and maintained MDH2 stability. Knockdown of MDH2 weakened the facilitating effect on cell metastasis and 2-hydroxyglutarate (2-HG) metabolism in AC020978-overexpressed NSCLC cells. Yes Functional studies showed that AC020978 promoted NSCLC migration and invasion both in vitro and in vivo. 34424600 AC016405.3 LncRNA Homo sapiens Breast Neoplasms BRCA tissues and cells Interaction(miR-22-3p/ERBB3 ) Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The results showed that AC016405.3 is highly expressed in BRCA tissues as well as cells and positively correlated with poor prognosis in BRCA patients. Mechanistically, AC016405.3 functioned as a competing endogenous RNA (ceRNA) for miR-22-3p in the cytoplasm and sponged miR-22-3p to release its suppression of ERBB3. The results showed that AC016405.3 is highly expressed in BRCA tissues as well as cells and positively correlated with poor prognosis in BRCA patients Yes Silencing AC016405.3 obviously repressed the malignant behaviors of BRCA cells. 34403532 AC114812.8 LncRNA Homo sapiens Urinary Bladder Neoplasms cell lines(T24，UM-UC-3，J82) Regulation[miR-371b-5p/FUT4 axis] CCK8//Wound Healing Assay//Luciferase Report Assay//Transwell Assay Our findings revealed that AC114812.8 was significantly upregulated in BC and could markedly facilitate the proliferation, migration, and invasion of bladder cancer cells both in vitro and in vivo. Furthermore, duel-luciferase reporter assay revealed that AC114812.8 could regulate the FUT4 expression level by sponging miR-371b-5p to facilitate BC progression. We detected the levels of EMT-related biomarkers in AC114812.8-overexpressing BC cells by western blot analysis and found that AC114812.8 could promote EMT process. Rescue experiments showed that miR-371b-5p could rescue the effect of AC114812.8 on proliferation and metastasis of BC. Our results suggest that AC114812.8 could be a novel prognostic biomarker and therapeutic target for bladder cancer. Yes Our findings revealed that AC114812.8 was significantly upregulated in BC and could markedly facilitate the proliferation, migration, and invasion of bladder cancer cells both in vitro and in vivo. 31706102 AC136007.2 LncRNA Homo sapiens Cerebral Ischaemia/Reperfusion Injury SH-SY5Y cells Regulation(AMPK/mTOR) Western Blot//Tunel//qRT-PCR//Cell Apoptosis Assay//EdU Staining//IF OGD/R downregulated AC136007.2 expression in SH-SY5Y cells, decreased viability by inducing apoptosis, and stimulated secretion of TNF-α, IL-6, and IL-1β. We conclude that AC136007.2 alleviates cerebral I/R injury by suppressing AMPK/mTOR-dependent autophagy. Yes OGD/R downregulated AC136007.2 expression in SH-SY5Y cells, decreased viability by inducing apoptosis, and stimulated secretion of TNF-α, IL-6, and IL-1β. 34419936 circCACTIN CircRNA Homo sapiens Stomach Neoplasms Gastric Cancer tissues Interaction[Sponging MiR-331-3p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Microarray//IHC//Invasion Assay CircCACTIN expression was obviously up-regulated in GC tissues and cell lines.Binding interactions were detected between circCACTIN and miR-331-3p, and between miR-331-3p and TGFBR1 by Dual-luciferase reporter assays. Mechanistically, we demonstrated that circCACTIN promoted gastric cancer progression by sponging miRNA-331-3p and regulating TGFBR1 mRNA expression. Yes Knockdown of circCACTIN inhibited GC cells proliferation, migration, invasion and EMT. Enforced-expression of circCACTIN promoted GC cells migration, invasion and EMT, but had no effect on GC cells proliferation. Moreover, in vivo experiments, circCACTIN up-regulation promoted GC tumor growth and EMT, and circCACTIN down-regulation inhibited GC tumor growth and EMT. 31182928 AC245100.4 LncRNA Homo sapiens Prostatic Neoplasms PCa cells Regulation qRT-PCR//migration assay//Western Blot The AC245100.4 or PAR2 knockdown resulted in a decrease in Vimentin but an increase in E-cadherin protein levels, while the AC245100.4 or PAR2 overexpression got the opposite results. Moreover, we discovered that AC245100.4 activated the p38-MAPK via regulating PAR2. In brief, these results have suggested that AC245100.4 and PAR2 served as oncogenic factors in cellular migration in PCa cells. Yes We found that AC245100.4 promoted the migration of prostate cancer cells via regulating PAR2. 35570225 ADAMTS9-AS1 LncRNA Homo sapiens Endometriosis murine model of EMs Interaction(miR-6516-5p/GPX4-dependent ferroptosis) RNA Pull-Down//Western Blot//Tunel//Migration Assay//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay The current data showed that ADAMTS9-AS1 expression was significantly upregulated in ecEM compared with eutopic endometrium (euEM) in patients with EMs and in a murine model of EMs. Taken together, these results demonstrate that upregulated ADAMTS9-AS1 accelerates ESC proliferation and migration by regulating miR-6516-5p/GPX4-dependent ferroptosis and may be a potential target for the treatment of EMs. Yes Functionally, ADAMTS9-AS1 knockdown in ectopic ESCs (EESCs) decreased cell viability and migration, whereas ADAMTS9-AS1 overexpression in normal ESCs (NESCs) enhanced cell viability and migration. More importantly, the effect of ADAMTS9-AS1 inhibition on decreasing ESC viability was significantly blocked by ferrostatin-1 (Fer-1, a ferroptosis inhibitor), and ADAMTS9-AS1 overexpression repressed erastin (a ferroptosis activator)-induced cell death. 35173188 ADAMTS9-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines interaction[Sponging miR-513a-5p] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay ADAMTS9-AS1 was downregulated in breast cancer tissues as well as cell lines. In conclusion, lncRNA ADAMTS9-AS1 inhibited the aggressive phenotypes of breast carcinoma cells via sponging miR-513a-5p and regulating ZFP36. Yes Upregulation of ADAMTS9-AS1 suppressed the growth and invasiveness of breast carcinoma cells in vitro as well as inhibiting cellgrowth in vivo. 33149676 ADAMTS14 CircRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues,cell lines Interaction[miR-572/ RCAN1] Microarray//PCR//IF CircADAMTS14 and RCAN1 were lowly expressed in HCC clinical specimens and cell lines using microarrays and qRT-PCR, but miR-572 inversely. Yes Overexpressed circADAMTS14 and RCAN1 induced apoptosis of HCC cells and inhibited cell proliferation and invasion. But overexpressed miR-572 could decrease apoptosis of HCC cells and promote proliferation and invasion. In vivo, circADAMTS14 inhibited the tumor growth, correlated positively with the protein expression levels of RCAN1 30317540 ADAM9 CircRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines Interaction[ADAM9/miR-217/PRSS3] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay In this research, low miR-217 and high circ-ADAM9 expression were found in PC tissues and cell lines, which was closely associated with advanced clinical stage and lymph node metastasis.Stepwise mechanism studies indicated that circ-ADAM9 alleviated the inhibitory effect of miR-217 on PRSS3 by directly sponging miR-217 to increase the expression level of PRSS3, resulting in the activation of ERK/VEGF signalling pathway. In vivo, circ-ADAM9 silencing or miR-217 overexpression evidently retarded the growth of tumour, and the combination of them exhibited an additive inhibitory effect on tumourigenicity. Briefly, the ceRNA regulatory network of circ-ADAM9/miR-217/PRSS3 plays a pivotal role in PC progression by the regulation of ERK/VEGF signalling pathway. In this research, low miR-217 and high circ-ADAM9 expression were found in PC tissues and cell lines, which was closely associated with advanced clinical stage and lymph node metastasis. Patients with low miR-217 or high circ-ADAM9 expression had shorter survival time than those with high miR-217 or low circ-ADAM9 expression. Yes Functionally, manipulation of miR-217 and circ-ADAM9 expression showed opposite effects on cell proliferation, migration and invasion. 31810373 ACVR2A CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-1290 ) colony Formation Assay//RNA Pull-Down//Transfection//Colony Formation Assay//CCK8//qRT-PCR//RIP//PCR//IP//Transwell Assay//IF The relative level of circACVR2A in GC tissues and cell lines is remarkably upregulated. The downregulation of circACVR2A promotes GC cell proliferation and metastasis and suppressed the expression level of E-cadherin and Vimentin. The miR-1290 inhibitor reversed the effect of circACVR2A on cell progression in GC cell. Yes The downregulation of circACVR2A promotes GC cell proliferation and metastasis and suppressed the expression level of E-cadherin and Vimentin. 35186081 acv3UTR LncRNA Homo sapiens Stomach Neoplasms GC tissue regulation[miR-590-5p/YAP1 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay Here, we found that acvr1b gene 3'UTR (acv3UTR) was elevated in GC tissue, the expression of which was significantly correlated with advanced pTNM-stage and poor outcome in clinical patients.Mechanistically, our results suggested that acv3UTR functioned as an oncogenic competing endogenous RNA via sponging miR-590-5p and enhancing YAP1 level. Here, we found that acvr1b gene 3'UTR (acv3UTR) was elevated in GC tissue, the expression of which was significantly correlated with advanced pTNM-stage and poor outcome in clinical patients. Yes Forced expression of acv3UTR promoted GC cells growth in vitro and in vivo. 32066878 ACTA2-AS1 LncRNA Homo sapiens Stomach Neoplasms GC cells Interaction(miR-378a-3p/PLCXD2 axis) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Reverse transcription-quantitative polymerase chain reaction analyses and subcellular fractionation assays showed that ACTA2-AS1 was lowly expressed in GC cells and was mainly distributed in the cytoplasm. Mechanistically, ACTA2-AS1 served as a competing endogenous RNA (ceRNA) to bind with miR-378a-3p and thereby, antagonized the inhibitory effect of miR-378a-3p on the expression of messenger RNA phosphatidylinositol specific phospholipase C X domain containing 2 (PLCXD2). The binding capacity between miR-378a-3p and ACTA2-AS1 (or PLCXD2) was detected by RNA pulldown assays, luciferase reporter assays and RNA immunoprecipitation assays. Moreover, PLCXD2 knockdown rescued the inhibitory effect of ACTA2-AS1 overexpression on malignant behaviors of GC cells. Overall, ACTA2-AS1 inhibits malignant phenotypes of GC cells by acting as a ceRNA to target miR-378a-3p/PLCXD2 axis. Yes Overexpressed ACTA2-AS1 inhibited GC cell viability, proliferation, migration, invasion, and epithelial-mesenchymal transition process, as suggested by cell counting kit-8 assays, colony formation assays, wound healing assays, Transwell assays and Western blot analyses. 35274046 ACTA2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression(lower expressed) RNA Pull-Down//Western Blot//ISH//Wound Healing Assay//CCK8//qRT-PCR//FISH//Colony Formation Assay//Transwell Assay ACTA2-AS1 expression was downregulated in CRC. Collectively, ACTA2-AS1 inhibits the viability, proliferation, migration and invasion of CRC cells to effectively suppress the progression of CRC. Yes Overexpressed ACTA2-AS1 repressed the cell viability, proliferation, migration and invasion, increased cleaved caspase-3 level yet decreased PCNA, Bcl-2, MMP-2 and MMP-9 levels. ACTA2-AS1 silencing, however, did oppositely. 35325674 ACTA2-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-532-5p /CXCL2) Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Compared with paracancerous tissues and HOSEpiC cells, OC tissues and cells showed increased ACTA2-AS1 and CXCL2 expression and decreased miR-532-5p expression (all P<0.05). ACTA2-AS1 acted as ceRNA in OC by negatively regulating miR-532-5p. Moreover, CXCL2, positively correlated with ACTA2-AS1 in expression (P<0.0001, r=0.7385), was the target of miR-532-5p, and its overexpression could partially offset the influence of miR-532-5p on OC cells. Yes Additionally, upregulating ACTA2-AS1 intensified the proliferation and invasion of cancer cells and suppressed their apoptosis (all P<0.05), and inhibition of it resulted in opposite results. In contrast, overexpressing miR-532-5p suppressed the proliferation, invasion, and clone formation of the cells and promoted their apoptosis (all P<0.05). The effect of ACTA2-AS1 on OC cells can be partially reversed by overexpressing miR-532-5p. 34093945 ACTA2-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells regulation[ ACTA2-AS1/miR-143-3p/SMAD3 axis ] CCK8//qRT-PCR//Flow Cytometry//Cell Cycle Assay//Colony Formation Assay//Transwell Assay ACTA2-AS1 was significantly increased in CC tissues and cells and miR-143-3p was down-regulated. The ACTA2-AS1/miR-143-3p/SMAD3 axis can play a crucial role in cervical carcinogenesis, providing new clues for the early diagnosis and treatment of CC. Clinically, the higher expression of ACTA2-AS1 was significantly correlated with higher FIGO stage. Yes Loss-of-function assay revealed that silencing of ACTA2-AS1 inhibited cell proliferation, colony formation, migration and promoted apoptosis in CC. 32774166 ACTA2-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms 119 patients and cell lines Interaction(miR-532-5p) Cell Proliferation Assay//qRT-PCR//Transfection//Luciferase Report Assay The TNBC tissues were collected from 119 patients, where the reduced level of ACTA2-AS1 and increased level of miR-532-5p were observed by PCR and showed a significantly negative correlation (P < 0.001). Moreover, in TNBC cell, overexpressing ACTA2-AS1 was found to suppress cell proliferation and metastasis, which was reversed by the upregulation of miR-532-5p. Both ACTA2-AS1 and miR-532-5p were closely associated with the malignant development and poor prognosis of TNBC patients. Yes Moreover, in TNBC cell, overexpressing ACTA2-AS1 was found to suppress cell proliferation and metastasis, which was reversed by the upregulation of miR-532-5p. 35896973 ACTA2-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD samples and cells regulation[miR-378a-3p and miR-4428,SOX7 ] qRT-PCR In this paper, ACTA2-AS1 was identified as a downregulated lncRNA in LUAD samples and cells. To summarize, ACTA2-AS1 suppresses the malignant processes of LUAD cells through sequestering miR-378a-3p and miR-4428 to augment SOX7 expression. Yes Functionally, ACTA2-AS1 overexpression restrained cell proliferation but accelerated cell apoptosis in LUAD. In addition, we determined the suppressive effect of ACTA2-AS1 on LUAD cell invasion, migration, and epithelial-mesenchymal transition progress. 32808728 ACTA2-AS1 LncRNA Homo sapiens Liver Neoplasms liver cancer tissues and cell lines Expression[lower expressed] Flow Cytometry//qRT-PCR//Western Blot//Transwell Assay As demonstrated in Fig. 1, the expression level of ACTA2-AS1:4 in cancerous tissues collected from 17 patients with liver cancer was significantly downregulated compared with the corresponding adjacent non-cancerous tissues (P<0.05; Fig. 1A). Yes This inhibition of ACTA2‑AS1:4 expression significantly promoted the proliferation, cell cycle progression, migration and invasion of LM3 cells. 30664183 ACTA2-AS1 LncRNA Homo sapiens Colonic Neoplasms human colon adenocarcinoma tissues and colon adenocarcinoma cell lines Interaction(miR-4428/BCL2L11) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis ACTA2-AS1 was obviously downregulated in human colon adenocarcinoma tissues and colon adenocarcinoma cell lines. In addition, luciferase reporter assay revealed that ACTA2-AS1 interacted with miR-4428 and suppressed its expression. miR-4428 could bind to 3' untranslated region of BCL2L11 and modulated the expression of BCL2L11 negatively. Knockdown of ACTA2-AS1 and over-expression of BCL2L11 reversed the biological function that ACTA2-AS1 mediated by knockdown ACTA2-AS1 alone. Yes Silence or over-expression of ACTA2-AS1 promoted or inhibited cell proliferation and colony formation abilities, and regulated apoptosis. The silence of ACTA2-AS1 resulted in the decrease of Bax and increase of Bal2, while restored in OE ACTA2-AS1 group when compared with the control transfected cells. 33845844 ACAP2 CircRNA Homo sapiens Colonic Neoplasms colon cancer tissue and colon cancer SW480 cells Regulation[ACAP2/Hsa-miR-21-5p/ Tiam1] Western Blot//PCR//IF CircRNA-ACAP2 and Tiam1 were shown to be highly expressed in colon cancer tissue and colon cancer SW480 cells, but miR-21-5p was expressed at a low level.The present study shows that the circRNA-ACAP2/hsa-miR-21-5p/Tiam1 regulatory feedback circuit could affect the proliferation, migration, and invasion of colon cancer SW480 cells. Yes SW480 cell proliferation was suppressed when the expression of circRNA-ACAP2 and Tiam1 was decreased and the expression of miR-21-5p was increased in vivo and in vitro. 30212824 ACACA CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-1183 and PI3K/PKB pathway] Western Blot//qPCR//PCR//IP//IF The level of circ?ACACA was markedly upregulated in NSCLC tissues and cells, which was contrary to the expression of miR?1183.Knockdown of circ‑ACACA impeded NSCLC progression by sponging miR‑1183 and inactivating the PI3K/PKB signaling pathway. Yes Knockdown of circ?ACACA inhibited proliferation and migration of NSCLC cells and also reduced the glycolysis rate. 32236577 AC245100.4 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines regulation[microRNA-145-5p/RBBP5 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The present study identified that AC245100.4 expression was significantly upregulated in PCa tissues and cell lines.Overall, the present study proposed a novel model in which the AC245100.4/miR‑145‑5p/RBBP5 ceRNA network induced the development of PCa, providing novel insights for PCa treatment. Yes Knockdown of AC245100.4 impaired tumor growth in an animal model. Biological function analysis indicated that AC245100.4 overexpression notably promoted cell proliferation and migration, while knockdown of AC245100.4 suppressed cell proliferation and migration. 33416179 AC245100.4 LncRNA Homo sapiens Prostatic Neoplasms prostate tissues interaction[binds HSP90 ] CCK8//qRT-PCR//RIP//FISH AC245100.4 expression was upregulated in prostate cancer and mainly located in the cytoplasm. AC245100.4 promotes the proliferation of prostate cancer via binding of HSP90. Yes Knockdown of AC245100.4 inhibited proliferation of prostate cancer. 32811161 AC016405.3 LncRNA Homo sapiens Glioblastoma GBM tissue,cell lines Interaction[modulation of TET2 by microRNA-19a-5p sponging ] Western Blot//ISH//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Microarray//Transwell Assay It showed that AC016405.3 was downregulated in GBM tissue specimens and cell lines, and it also illustrated that the downregulated AC016405.3 was closely correlated with several aggressive features of patients with GBM. In summary, the findings of the current study identified a novel lncRNA and illustrated that AC016405.3, acting as an anti-oncogene, suppressed GBM cell proliferation and metastasis by regulating TET through miR-19a-5p sponging. Our present study might provide a new axis in the molecular treatment of GBM. Yes Functionally, we found that overexpression of AC016405.3 suppressed GBM cells' proliferation and metastasis using a gain of function experiment. 30888082 AC012668 LncRNA Mus musculus Non-alcoholic Fatty Liver Disease free fatty acid-treated LO2 cells and high-fat diet-fed mice Interaction(miR-380-5p/LRP2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Microarray//Oil Red O Staining//ELISA AC012668 expression levels were significantly suppressed in NAFLD models, whereas AC012668 overexpression inhibited lipogenesis-related gene (SCD1, SREBP1, FAS) expression and TG/lipid accumulation in vitro.Subsequently, miR-380-5p was predicted and verified to target AC012668, and its expression was notably increased in the NAFLD cell model. AC012668 inhibited NAFLD progression via the miR-380-5p/LRP2 axis. Yes AC012668 expression levels were significantly suppressed in NAFLD models, whereas AC012668 overexpression inhibited lipogenesis-related gene (SCD1, SREBP1, FAS) expression and TG/lipid accumulation in vitro. 34511037 AC009948.5 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD samples and cells Interaction(miR-186-5p/NCAPG2) In Vivo Experiment//RNA Pull-Down//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Bioinformatics Analysis//Transwell Assay LncRNA expression microarray data indicate that LncRNA-AC009948.5 is upregulated in LUAD samples. The present study confirmed the upregulation of LncRNA-AC009948.5 in LUAD tissues and cells. Conversely, LncRNA-AC009948.5 upregulated had opposite effects. Mechanistically, we elucidated that LncRNA-AC009948.5 could directly bind to miR-186-5p and subsequently suppress expression of the target gene of NCAPG2. Encreased expression of LncRNA-AC009948.5 was correlated with tumor size, lymph nodes, distant metastasis and histological grade, and poor prognosis. Yes LncRNA-AC009948.5 knockdown significantly inhibited cell proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. 36059662 AC009022.1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction[suppressing miR-497-5p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay AC009022.1 expression was abnormally elevated in CRC tissues and cells. AC009022.1 enhanced CRC cell proliferation, migration, and invasion by promoting ACTR3B expression via suppressing miR-497-5p. High AC009022.1 expression in CRC patients was significantly associated with poor prognosis. Yes Much lower subcutaneous tumor volume and weight were found in the siAC009022.1 group compared with siNC group (P < .001). 31637768 91H LncRNA Homo sapiens Osteosarcoma Five pairs of osteosarcoma tissues and adjacent normal tissues Interaction(CDK4) CCK8//qRT-PCR//Western Blot Knockdown of 91 H significantly inhibited the growth of osteosarcoma cells via inducing the cell apoptosis. Meanwhile, knockdown of 91 H inhibited the progression of osteosarcoma via inducing methylation of CDK4 promoter. Yes Knockdown of 91 H significantly inhibited the growth of osteosarcoma cells via inducing the cell apoptosis. In addition, 91 H siRNA notably suppressed the migration and invasion of osteosarcoma cells. 33499776 34936303 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction(miR182/Foxo3a axis) Western Blot//Transfection//qPCR//PCR//IF The expression of CRIM1 in adjacent tissues was significantly down-regulated and negatively correlated with distal migration. After circRNA CRIM1 was overexpressed, the miR-182 was significantly down-regulated. The expression levels of Foxo3a mRNA and proteins were up-regulated after miR-182 silencing of bladder cancer cell line UMUC3. Yes . The overexpression of circRNA CRIM1 reduced migration and invasion processes in bladder cancer cells. 34994952 17A LncRNA Homo sapiens Alzheimer Disease cell lines Expression[highly expressed] Western Blot//Migration Assay//qRT-PCR//Cell Apoptosis Assay//Cell Cycle Assay//ELISA//Invasion Assay//IF As shown in Figure 1., our data found that the expression level of 17A was significantly enhanced in negative control (NC) cells which had been treated with Aβ 1-42 peptide, compared with that of the normal cells (P < 0.05). Yes These data demonstrated that 17A depletion inhibited cell apoptosis, whereas the up-regulation of 17A promoted apoptosis, as shown in Figure 2. 30652945 1700020I14Rik LncRNA Homo sapiens Hepatitis, Alcoholic AML12 cell Interaction(miR-137/AKR1B10 /Erk signaling) In Vivo Experiment//Western Blot//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//ELISA//Bioinformatics Analysis//IF We found elevated AKR1B10 and 1700020I14Rik but reduced miR-137 in AH.1700020I14Rik was able to elevated miR-137-mediated AKR1B10. In vitro cell experiments and in vivo animal experiments validated that 1700020I14Rik reduced ethanol-induced hepatocyte damage and inflammation in AH mice through regulation of miR-137-mediated AKR1B10/Erk axis. Yes In vitro cell experiments and in vivo animal experiments validated that 1700020I14Rik reduced ethanol-induced hepatocyte damage and inflammation in AH mice through regulation of miR-137-mediated AKR1B10/Erk axis. 36028503 hsa_circ_0009910 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Expression[highly expressed] qRT-PCR//Western Blot Circ_0009910 expression level was elevated in GC tissues and cell lines and associated with clinical stage (p = 0.032), distant metastasis (p = 0.028) and differentiation (p = 0.007). Circ_0009910 expression level was elevated in GC tissues and cell lines and associated with clinical stage (p = 0.032), distant metastasis (p = 0.028) and differentiation (p = 0.007).Kaplan-Meier survival analysis indicated that circ_0009910 expression in positive group has a worse overall survival compared to the negative group (p = 0.0013). Multivariate analysis showed that circ_0009910 was an independent risk factor for GC (HR = 2.346, 95% CI: 1.673-3.775, p = 0.006). Yes Knockdown of circ_0009910 expression can suppress BGC823 and AGS cells proliferation, migration and invasion in vitro experiments. 30556864 hsa_circ_0027599 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues interaction[miR-101-3p.1] qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Western Blot The circRNA expression profile in the gastric cancer tissues by circRNA microarray showed that hsa_circ_0027599 (circ_0027599) was significantly down-regulated in gastric cancer patients and cells when comparing with the controls.The study uncovered that PHLDA1 was regulated by circ_0027599/miR-101, which suppressed gastric cancer survival and metastasis in gastric cancer. Yes Circ_0027599 overexpression suppressed gastric cancer cell proliferation and metastasis. 30410722 circYAP1 CircRNA Homo sapiens Stomach Neoplasms GC tissues Regulation[miR-367-5p/p27 Kip1 axis] qRT-PCR//FISH//Luciferase Report Assay//Western Blot CircYAP1 expression level was significantly lower in GC tissues than the adjacent normal tissues, and GC patients with circYAP1 low expression had shorter survival times as compared with those with circYAP1 high expression. Our findings demonstrate that circYAP1 functions as a tumor suppressor in GC cells by targeting the miR-367-5p/p27 Kip1 axis and may provide a prognostic indicator of survival in GC patients. CircYAP1 expression level was significantly lower in GC tissues than the adjacent normal tissues, and GC patients with circYAP1 low expression had shorter survival times as compared with those with circYAP1 high expression. Yes Functionally, circYAP1 overexpression inhibited cell growth and invasion in vitro and in vivo, but its knockdown reversed these effects. 30336780 hsa_circ_102958 CircRNA Homo sapiens Stomach Neoplasms CRC tissues and adjacent normal tissues Regulation[miR-585/CDC25B axis ] Western Blot//ISH//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that hsa_circRNA_102958 level was increased in tumor tissues (n=58) compared to adjacent normal tissues.Taken together, our findings revealed the novel oncogenic roles of hsa_circRNA_102958 in CRC through miR-585/CDC25B axis. Yes We showed that hsa_circRNA_102958 silencing markedly suppressed CRC growth, migration and invasion. 31413634 circOSBPL10 CircRNA Homo sapiens Stomach Neoplasms GC tissues and adjacent tissues Expression[highly expressed] Western Blot//FISH//Luciferase Report Assay//RNA-seq//PCR The expression levels of circOSBP10 were significantly higher in GC tissues than in noncancerous tissues (P = 0.0118, Fig. 2a). Furthermore, the level of circOSBPL10 was observed to be a prognostic marker of the overall survival and disease-free survival of patients with GC. Yes In vivo experiments showed that circOSBPL10 promotes tumor growth and metastasis in mice. 31409903 circGRAMD1B CircRNA Homo sapiens Stomach Neoplasms GC tissues and noncancerous tissues Interaction[miR-149] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining We screened differentially expressed circRNAs and found that circGRAMD1B expression was Expression[down-expression]regulated in GC tissues and cell lines. Functionally, circGRAMD1B acted as an anti-oncogene and inhibited the proliferation, migration, and invasion abilities of GC cells. Then, we verified that circGRAMD1B served as a sponge that targeted miR-130a-3p in GC cells; circGRAMD1B alleviated GC cell proliferation, migration, and invasion by targeting miR-130a-3p. A mechanistic analysis showed that PTEN and p21 were involved in circGRAMD1B/miR-130a-3p axis-inhibited GC tumorigenesis. Our findings suggest that circGRAMD1B plays an important role in GC progression by regulating miR-130a-3p-PTEN/p21, which may provide a potential biomarker and therapeutic target for GC. Yes  We screened differentially expressed circRNAs and found that circGRAMD1B expression was Expression[down-expression]regulated in GC tissues and cell lines. Functionally, circGRAMD1B acted as an anti-oncogene and inhibited the proliferation, migration, and invasion abilities of GC cells. Then, we verified that circGRAMD1B served as a sponge that targeted miR-130a-3p in GC cells; circGRAMD1B alleviated GC cell proliferation, migration, and invasion by targeting miR-130a-3p. A mechanistic analysis showed that PTEN and p21 were involved in circGRAMD1B/miR-130a-3p axis-inhibited GC tumorigenesis. Our findings suggest that circGRAMD1B plays an important role in GC progression by regulating miR-130a-3p-PTEN/p21, which may provide a potential biomarker and therapeutic target for GC. 31719211 hsa_circ_0001461 CircRNA Homo sapiens Stomach Neoplasms GC tissues Regulation[ miR-346/ FBXL2 axis] qRT-PCR//FISH We verified that circFAT1(e2) was significantly Expression[down-expression]regulated in GC tissues and cell lines and was correlated with overall survival of GC patients.Then, we investigated whether circFAT1(e2) acts as a sponge of microRNA-549g(miR-548g) and regulates the expression of tumor sExpression[Expression[up-expression]-expression]pressor RUNX1 in GC cells. Moreover, we found that nucleus-located circFAT1(e2) could directly interact with Y-box binding protein-1 (YBX1) and inhibit its function. Yes Functional assays indicated that overexpression of circFAT1(e2) inhibited GC cell proliferation, migration and invasion. 30419346 circNF1 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[miR-16] qRT-PCR//RNA-seq//Western Blot We analyzed next-generation RNA sequencing data from GC tissues and cell lines, identifying 75,201 candidate circRNAs. Among these, we focused on one novel circRNA, circNF1 , which was Expression[Expression[up-expression]-expression]regulated in GC tissues and cell lines. Furthermore, luciferase reporter assays showed that circNF1 binds to miR-16, thereby derepressing its Expression[down-expression]stream target mRNAs, MAP7 and AKT3. Targeted silencing or overexpression of circNF1 had no effect on levels of its linear RNA counterpart, NF1. Yes Loss- and gain-of-function studies demonstrated that circNF1 significantly promotes cell proliferation. 30576282 circLMTK2 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Western Blot//Transwell Assay CircLMTK2 expression was significantly Expression[down-expression]-regulated in gastric carcinoma tissue specimens (P<0.001) compared with its expression in paired normal tissues. Furthermore, a Kaplan-Meier analysis revealed that lower levels of circLMTK2 expression were associated with decreased overall survival (OS) (P<0.001), and a multivariate Cox hazards analysis showed that high circLMTK2 expression was an independent factor for OS. Yes Afterward, overexpression of circLMTK2 was performed in gastric cancer cell line MGC-803, and results indicated that malignant biological properties were inhibited by circLTMK2 overexpression. 30988068 hsa_circ_0001368 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Regulation[miR-6506-5p/FOXO3 axis ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Microarray In the current study, we found a broad Expression[down-expression]regulation of hsa_circ_0001368 in GC tissues and cells, which correlates with a worse prognosis in GC patients. Mechanically, we demonstrated that hsa_circ_0001368 served as a competing endogenous RNA (ceRNA) to sponge miR-6506-5p. Subsequently, FOXO3 may act as the functional target of miR-6506-5p, and the knockExpression[down-expression] of hsa_circ_0001368 decreased the expression of the tumor-sExpression[Expression[up-expression]-expression]pressive gene FOXO3. Yes Functional experiments suggested that the knockExpression[down-expression] of hsa_circ_0001368 promoted cell viability and motility by cell proliferation and invasion assays.In addition, the knockExpression[down-expression] of hsa_circ_0001368 led to accelerated tumor growth in vivo. 30853185 circNRIP1 CircRNA Homo sapiens Stomach Neoplasms GC tissues Interaction[AKT1/mTOR pathway] RNA Pull-Down//Western Blot//CCK8//Luciferase Report Assay//RNA-seq We detected higher circNRIP1 expression in gastric cancer by performing RNA-seq analysis.Western blot analysis and immunofluorescence assays were performed to demonstrate that the circNRIP1-miR-149-5p-AKT1/mTOR axis is responsible for the altered metabolism in GC cells and promotes GC development. Yes We discovered that knockdown of circNRIP1 successfully blocked proliferation, migration, invasion and the expression level of AKT1 in GC cells. 30717751 hsa_circ_001569 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[absorbing miR-145] RNA Pull-Down//Western Blot//CCK8//Luciferase Report Assay//PCR Both circRNA_001569 and NR4A2 were overexpressed in tissues and cells of gastric cancer, while miR-145 was down-regulated.CircRNA_001569 regulated the expression of miR-145, the effect of pcDNA-circRNA_001569 was abolished by miR-145 mimic and the effect of si-circRNA_001569 was abolished by miR-145 inhibitor. MiR-145 targets NR4A2 to regulate its expression. Overexpressed miR-145 sExpression[up-expression]pressed cell viability and promoted cell apoptosis. Yes Overexpressed circRNA_001569 significantly increased cell viability, and decreased cell apoptosis, while down-regulated circRNA_001569 dramatically decreased cell viability and promoted cell apoptosis. 30304349 hsa_circ_0000267 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[sponging MiR-503-5p and regulating HMGA2] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//BrdU//Transwell Assay Circ_0000267 showed a significant upregulation in GC tissues and cell lines, and its high expression level was extremely linked to the increased tumor diameter and local lymph node metastasis. dual-luciferase reporter gene assay was adopted to verify the targeting relationship between circ_0000267 and miR-503-5p.From the perspective of mechanism, circ_0000267 promoted the progression of GC through adsorbing miR-503-5p and upregulating HMGA2 expression. Circ_0000267 showed a significant upregulation in GC tissues and cell lines, and its high expression level was extremely linked to the increased tumor diameter and local lymph node metastasis. Yes Circ_0000267 overexpression accelerated GC cell proliferation, metastasis, and EMT processes, while knocking down circ_0000267 led to the opposite effect. 31845519 hsa_circ_0008035 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissue Regulation[miR-375/YBX1 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay This study aims to uncover the mechanism by which circRNAs regulate gastric cancer tumorigenesis. Among the microarray data, we screened dysregulated circRNAs and identified an up-regulated circRNA, hsa_circ_0008035. Functionally, the hsa_circ_0008035 silencing by the siRNA transfection inhibited the proliferation and invasion of gastric cancer cells. Yes Functionally, the hsa_circ_0008035 silencing by the siRNA transfection inhibited the proliferation and invasion of gastric cancer cells. 31105852 circRanGAP1 CircRNA Homo sapiens Stomach Neoplasms blood Interaction[targeting miR-877-3p] Western Blot//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Microarray//IHC Here, we identified that circ-RanGAP1 was significantly upregulated in both GC tissues and exosomes from the plasma of GC patients.Mechanistically, circ-RanGAP1 sponged miR-877-3p to upregulate VEGFA expression. Overexpression of miR-877-3p reversed the biological functions mediated by circ-RanGAP1 in GC cells. Interestingly, we demonstrated that circ-RanGAP1 was upregulated in plasma exosomes from preoperative GC patients. More importantly, the plasma exosomes derived from these patients enhanced the migration and invasion potential of GC cells. High circ-RanGAP1 expression was closely associated with an advanced TNM stage, lymph node metastases, and worse survival. Yes Inhibition of circ-RanGAP1 decreased GC cell invasion and migration in vitro. Overexpression of circ-RanGAP1 had the opposite effect. Additionally, circ-RanGAP1 silencing remarkably suppressed tumor growth and metastasis of GC in vivo. 31811909 A1BG-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[targeting miR-216a-5p] qRT-PCR Further analyses confirmed that A1BG-AS1 expression in HCC was markedly lower than that in noncancerous tissues based on our HCC cohort. A1BG-AS1 positively regulated the levels of phosphatase and tensin homolog and SMAD family member 7, which were reduced by miR-216a-5p in HCC cells. Clinical association analysis revealed that low A1BG-AS1 expression correlated with poor prognostic features, such as microvascular invasion, high tumor grade, and advanced tumor stage. Follow-up data indicated that low A1BG-AS1 level evidently correlated with poor clinical outcomes of HCC patients. Yes Moreover, forced expression of A1BG-AS1 repressed proliferation, migration, and invasion of HCC cells in vitro. Conversely, A1BG-AS1 knockdown promoted these malignant behaviors in HepG2 cells. 30556161 A1BG-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction(miR-485-5p/FLOT1 pathway) Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Invasion Assay//Transwell Assay We found A1BG-AS1 to be highly expressed in breast cancer tissues and cell lines. Mechanistic investigations confirmed that A1BG-AS1 directly interacted with miR-485-5p as a molecular sponge. We demonstrated that FLOT1 is a direct target of miR-485-5p, which could be positively regulated by A1BG-AS1 by competing for miR-485-5p. Yes In terms of function, depleted A1BG-AS1 markedly suppressed cell proliferation, accelerated cell apoptosis, and hindered cell migration and invasion in breast cancer. Furthermore, A1BG-AS1 interference reduced tumor growth in vivo. 34115333 A2M-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction( miR-587/BMP3) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay In this study, A2M-AS1 was downregulated in LUAD tissues and cells and related to poor prognosis in LUAD patients. Mechanistically, A2M-AS1 directly bound with miR-587 to promote BMP3 expression in LUAD cells. In this study, A2M-AS1 was downregulated in LUAD tissues and cells and related to poor prognosis in LUAD patients. Low expression of BMP3 was found in LUAD tissues and cells and was closely correlated with poor prognosis in LUAD patients. Yes A2M-AS1 overexpression suppressed LUAD cell proliferation, migration and invasion in vitro and inhibited tumor growth in vivo. 36461613 ABCB10 CircRNA Homo sapiens Carcinoma, Ovarian Epithelial cell lines Interaction(miR‑1271‑mediated Capn4/Wnt/β‑catenin signaling pathway ) Western Blot//Transfection//qPCR//PCR//IF circ‑ABCB10 expression was significantly increased in OVCAR3, SKOV3 and CAOV3 cells compared with IOSE80 cells, but was not significantly altered in UWB1.289 cells. miR‑1271 expression was significantly decreased in OVCAR3, UWB1.289, SKOV3 and CAOV3 cells compared with IOSE80 cells. In both SKOV3 and UWB1.289 cells, circ‑ABCB10 negatively regulated miR‑1271, whereas miR‑1271 did not affect circ‑ABCB10. Moreover, miR‑1271 attenuated the proproliferative, proinvasive and antiapoptotic effects of circ‑ABCB10, and reversed the positive regulation of circ‑ABCB10 on the Capn4/Wnt/β‑catenin signaling pathway. Besides, the luciferase activity assay indicated that circ‑ABCB10 directly bound to miR‑1271. Yes Furthermore, circ‑ABCB10 enhanced cell proliferation, invasion and the Capn4/Wnt/β‑catenin signaling pathway, but inhibited cell apoptosis, whereas miR‑1271 suppressed cell proliferation, invasion and the Capn4/Wnt/β‑catenin signaling pathway, but facilitated cell apoptosis. 33760208 AC008972.1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues and cell lines Interaction( miR-143-3p/TAOK2) In Vivo Experiment//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Colony Formation Assay//Transwell Assay High expression of lncRNA AC008972.1 was associated with low overall survival in prostate cancer patients.LncRNA AC008972.1 bound with miR-143-3p and negatively regulated miR-143-3p expression. MiR-143-3p overexpression suppressed prostate cancer malignant behaviors in vitro. TAOK2 expression was decreased by miR-143-3p through the complementary targeting of TAOK2 mRNA. Downregulation of lncRNA AC008972.1 mitigated prostate cancer malignant behaviors in vitro based on miR-143-3p/TAOK2 node. High expression of lncRNA AC008972.1 was associated with low overall survival in prostate cancer patients. Yes Downregulation of lncRNA AC008972.1 suppressed prostate cancer progression by inhibiting cell viability, proliferation, migration, and invasion, in addition to the EMT process, whereas cell apoptosis was significantly promoted. Furthermore, the data of xenograft model experiment showed that inhibition of lncRNA AC008972.1 suppressed tumor growth in vivo. 36094409 AC007639.1 LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues Expression(highly expressed) qRT-PCR//Western Blot We found that lncRNA AC007639.1 was overexpressed in hepatocellular carcinoma. Yes Knocking down of lncRNA AC007639.1 by specific siRNAs or shRNAs promoted cancer cell death. The growth of mouse xenograft tumor created using lncRNA AC007639.1 deficient HepG2 cells was significantly slowed down. 34540685 AC007207.2 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(miR-1306-5p/SIRT7 Axis) qRT-PCR//Transwell Assay We found lncRNA AC007207.2 was over-expressed in OS tissues and cell lines, and this phenomenon was associated with the worse prognosis of OS.Moreover, we found that AC007207.2 promotes proliferation and metastasis of OS cells via the miR-1306-5p/SIRT7 axis. Meanwhile, we found miR-1306-5p remarkably inhibits the malignant behavior of OS cells. We found lncRNA AC007207.2 was over-expressed in OS tissues and cell lines, and this phenomenon was associated with the worse prognosis of OS. Yes Moreover, we found that AC007207.2 promotes proliferation and metastasis of OS cells via the miR-1306-5p/SIRT7 axis. Meanwhile, we found miR-1306-5p remarkably inhibits the malignant behavior of OS cells. 34584454 AC005592.2 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Regulation(OLFM4) CCK8//qRT-PCR//Western Blot//Transwell Assay AC005592.2 was significantly increased in CRC tissues and cells. In addition, AC005592.2 positively regulated the expression of olfactomedin 4 (OLFM4), which was also upregulated in CRC tissues. High expression of AC005592.2 was significantly associated with TNM stage and tumor differentiation in CRC patients. Yes Knockdown of AC005592.2 suppressed CRC cell proliferation, invasion and migration but promoted apoptosis, while AC005592.2 overexpression exerted the opposite effects on CRC cells. 33622275 AC002454.1 LncRNA Homo sapiens Endometriosis endometrium tissues Interaction[CDK6 ] qRT-PCR We confirmed AC002454.1 and CDK6 mRNA and protein were highly expressed in ectopic and eutopic endometrial tissue from patients with EMS and were clearly correlated. AC002454.1 and CDK6 may have synergistic effects, thereby affecting the biological behavior of endometrial cells, and thus promote the progression of EMS. Yes In vitro, both AC002454.1 and CDK6 positively regulated the proliferation, migration and invasion ability of eutopic endometrial cells and could promote the transformation of cells from G0/G1 phase to S phase. 30884467 ABCC6P2 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines Interaction[HNF4A ] qRT-PCR Quantitative real-time polymerase chain reaction (RT-PCR) implied that NR_023387 was significantly downregulated in RCC tissues and cell lines.Our combined analysis identifies a tumor-suppressive and prognosis-related lncRNA NR_023387, which is silenced in RCC via promoter hypermethylation and HNF4A deficiency, and may exert its tumor-suppressive roles by downregulating the oncogenic MGP. Quantitative real-time polymerase chain reaction (RT-PCR) implied that NR_023387 was significantly downregulated in RCC tissues and cell lines, and lower expression of NR_023387 was correlated with shorter overall survival. Yes Functional experiments demonstrated NR_023387 exerted tumor-suppressive roles in RCC via suppressing the proliferation, migration, invasion, tumor growth, and metastasis of RCC. 31432508 ABCC6P1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Regulation(Wnt/β-catenin pathway) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay//Transwell Assay The expression of ABCC6P1 was upregulated in PTC tissues and cells. In addition, knockdown of ABCC6P1 caused a significant decrease in levels of Wnt/β-catenin signaling pathway members (including β-catenin, c-myc, and cyclin D1) in PTC cells. Yes ABCC6P1 silencing could significantly suppress the proliferation, colony formation ability, migratory and invasive ability in PTC cells. Moreover, knockdown of ABCC6P1 induced cell cycle arrest at G0/G1 phase and inhibited epithelial-mesenchymal transition (EMT) process of PTC cells by increasing the E-cadherin expression, but downregulating N-cadherin and vimentin expression. 33987362 ABCB10 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-1915-3p/Rac1 axis) colony Formation Assay//Western Blot//Transfection//Colony Formation Assay//Flow Cytometry//qRT-PCR//IF//PCR//IHC//Transwell Assay Circ-ABCB10 expression was upregulated in GC tissues and cell lines and positively correlated with poor survival of GC patients. Circ-ABCB10 could upregulate Rac1 expression by directly sponging miR-1915-3p. Rescue experiments revealed that miR-1915-3p inhibitor obviously reversed the inhibitory effect of si-circ-ABCB10, and Rac1 overexpression obviously reversed the inhibitory effect of miR-1915-3p mimics on cell growth, invasion, migration, apoptosis, and cell cycle progression. Yes Circ-ABCB10 downregulation decreased cell viability, inhibited cell growth, invasion, and migration, while promoted cell apoptosis of GC cell lines SGC-7901 and MKN-48. Moreover, si-circ-ABCB10 effectively inhibited tumor growth in a xenograft model. 34987010 ABCB10 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC cells Interaction(miR-588/CXCR4 axis) colony Formation Assay//Western Blot//Wound Healing Assay//Colony Formation Assay//qRT-PCR//RIP//MTT//PCR//IP//Transwell Assay//IF Here, we were interested in the role of circABCB10 in the modulation of LSCC progression. Mechanically, circABCB10 served as a sponge for microRNAs-588 (miR-588) and miR-588 could target and down-regulated chemokine receptor 4 (CXCR4) expression in LSCC cells. Thus, we concluded that circABCB10 was involved in the malignant progression of LSCC by regulating miR-588/CXCR4 axis. Yes Our data demonstrated that the depletion of circABCB10 significantly inhibited the proliferation and induced the apoptosis of LSCC cells.Meanwhile, circABCB10 knockdown was able to remarkably reduce the invasion and migration of LSCC cells. 34015764 A2M-AS1 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer cells Interaction(PCBP3) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining The overexpression of A2M-AS1 promoted ferroptosis in the pancreatic cancer, which was inhibited by the silencing of A2M-AS1. Mechanically, A2M-AS1 could directly interact with the poly (rC) binding protein 3 (PCBP3), which plays an important role in the process of iron metabolism, thereby promoting the ferroptosis in pancreatic cancer. In addition, the A2M-AS1/PCBP3 axis could facilitate the p38 activation and inhibit the phosphorylation of the AKT-mTOR signaling pathway; all these participate in regulating ferroptosis. In conclusion, the regulation of ferroptosis by targeting the A2M-AS1/PCBP3 axis might provide a novel target for the treatment of pancreatic cancer in the future. Yes The overexpression of A2M-AS1 promoted ferroptosis in the pancreatic cancer, which was inhibited by the silencing of A2M-AS1. Mechanically, A2M-AS1 could directly interact with the poly (rC) binding protein 3 (PCBP3), which plays an important role in the process of iron metabolism, thereby promoting the ferroptosis in pancreatic cancer. 35920801 ABCA15P LncRNA Homo sapiens Stomach Neoplasms gastric cancer cells and tissues Interaction(CRYM) Western Blot//qRT-PCR//RIP//MTT//ChIP CRYM-AS1 was low expressed in gastric cancer cells and tissues compared with normal gastric cells and tissues respectively. Forced expression of CRYM rescued the decreased aerobic glycolysis and cell proliferation induced by CRYM-AS1 in gastric cancer cells. CRYM-AS1 was negatively correlated with TNM staging, tumor size, and overall survival (OS) rate in gastric cancer patients. Yes CRYM-AS1 inhibited gastric cancer cell aerobic glycolysis and cell proliferation. CRYM-AS1 directly bound to EZH2 and mediated the CRYM promoter methylation and consequently negatively regulated the expression of CRYM. 35414504 AB209371 LncRNA Homo sapiens ovarian carcinoma OC tissues Regulation[down-regulating miR-203 ] CCK8//qRT-PCR//Western Blot We found that AB209371 gene and Survivin gene were up-regulated in OC and positively correlated with OC development.Therefore, AB209371 may down-regulate miR-203 to up-regulate Survivin, thereby promoting OC cell proliferation. Our study provided novel insights into the pathogenesis of OC. AB209371 over-expression led to up-regulated Survivin in OC cells, while Survivin over-expression failed to affect AB209371. Yes In addition, over-expressions of AB209371 and Survivin resulted in the increased proliferation rate of OC cells. 31601255 AATBC LncRNA Homo sapiens Breast Neoplasms breast cancer patients Interaction(YBX1 and activating the YAP1/Hippo signaling pathway) RNA Pull-Down//Western Blot//ISH//Wound Healing Assay//Co-IP//RIP//IF//Luciferase Report Assay//IHC//Transwell Assay In this study, the lncRNA apoptosis-associated transcript in bladder cancer (AATBC) was found to be significantly highly expressed in breast cancer patients. Further studies revealed that AATBC activated the YAP1/Hippo signaling pathway through the AATBC-YBX1-MST1 axis. This is also an important supplement to the composition of the YAP1/Hippo signaling pathway. Yes In vitro and in vivo experiments indicated that AATBC promoted breast cancer metastasis. 33951538 AATBC LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells Interaction(miR-1245b-5p) Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Significant upregulation of AATBC and reduced miR-1245b-5p level in cervical cancer were observed, which showed a negative correlation between their expression levels. Close relationships of AATBC and miR-1245b-5p with the FIGO stage and lymph node metastasis were revealed. AATBC showed a significant prognostic value and miR-1245b-5p was found to mediate the tumor inhibitory effect of AATBC knockdown, which is speculated to be the underlying molecular mechanism of AATBC in cervical cancer development. Upregulation of AATBC indicted the malignant development and adverse prognosis of cervical cancer. Yes Close relationships of AATBC and miR-1245b-5p with the FIGO stage and lymph node metastasis were revealed. AATBC showed a significant prognostic value and miR-1245b-5p was found to mediate the tumor inhibitory effect of AATBC knockdown, which is speculated to be the underlying molecular mechanism of AATBC in cervical cancer development. 36420764 AATBC LncRNA Homo sapiens Nasopharyngeal carcinoma regulation[miR-1237-3p-PNN-ZEB1 axis] Western Blot//ISH//qRT-PCR//Luciferase Report Assay//Transwell Assay AATBC was found to be highly expressed in nasopharyngeal carcinoma (NPC), and increased AATBC expression was associated with poor survival in patients with NPC. Collectively, our results indicate that AATBC promotes NPC progression through the miR-1237-3p-PNN-ZEB1 axis. AATBC was found to be highly expressed in nasopharyngeal carcinoma (NPC), and increased AATBC expression was associated with poor survival in patients with NPC. Yes Furthermore, AATBC promoted migration and invasion of NPC cells in vitro, as well as metastasis in vivo. 32364663 AATBC LncRNA Homo sapiens Prostatic Neoplasms Pca tissues Interaction(miR-1245b-5p/CASK Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay Firstly, we certified that the expression of AATBC was augmented in PCa, and knockdown of AATBC could significantly inhibit the growth of PCa in vitro and in vivo. Mechanistically, our results manifested that AATBC could directly bind to miR-1245b-5p. In addition, miR-1245b-5p played cancer-suppressive role in PCa cells. Moreover, CASK was attested as the target of miR-1245b-5p, and CASK was demonstrated to exert as oncogene in the progression of PCa. Yes Firstly, we certified that the expression of AATBC was augmented in PCa, and knockdown of AATBC could significantly inhibit the growth of PCa in vitro and in vivo. 34234553 A2M-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells interaction[Sponging microRNA-146b to Upregulate MUC19] RNA Pull-Down//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay A2M-AS1 and MUC19 were highly expressed in BC, while miR-146b was poorly expressed. Taken above together, an oncogenic role for A2M-AS1 in BC was elicited by acting as a miR-146b sponge to promote MUC19 expression. The findings will present some cues for a further approach to BC. Yes A2M-AS1 accelerated BC cell proliferation, invasion, and colony formation and suppressed apoptosis via the miR-146b/MUC19/Hippo axis, which was confirmed in vivo. 33273850 A2M-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay Of these lncRNAs, A2M-AS1, a lncRNA that has not been previously reported, was significantly upregulated in human breast cancer tissues compared with adjacent nontumour tissues. Yes The results revealed that A2M-AS1 significantly promotes human breast cancer cell proliferation, invasion, and migration. 32352014 ARHGAP10 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues, cells, and serum-derived exosomes Interaction( miR-638/FAM83F Axis) qRT-PCR//MTT//Luciferase Report Assay//Western Blot circARHGAP10 was upregulated in NSCLC tissues, cells, and serum-derived exosomes.Serum-derived exosomes boosted the expression of circARHGAP10 in NSCLC cells. Also, miR-638 acted as a target of circARHGAP10, miR-638 overexpression overturned circARHGAP10 upregulation-mediated acceleration of proliferation, migration, invasion, and glycolysis of NSCLC cells. Besides, miR-638 targeted FAM83F and FAM83F overexpression abolished miR-638 enhancement-mediated proliferation, migration, invasion, and glycolysis of NSCLC cells. Yes circARHGAP10 depletion repressed proliferation, migration, invasion, and glycolysis of NSCLC cells in vitro, and curbed tumor growth in vivo. 32783691 ARHGAP27P1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines,blood Interaction[regulating p15 and p16] IHC//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//FISH//RIP//Cell Cycle Assay//Colony Formation Assay//Invasion Assay//ChIP Herein, we confirmed that ARHGAP27P1 was significantly downregulated in GC tissues, plasma and cells. Mechanistic investigations showed that ARHGAP27P1 had a key role in G0/G1 arrest. We further demonstrated that ARHGAP27P1 was associated with Jumonji-domain containing 3 (JMJD3) and that this association was required for the demethylation of H3K27me3, thereby epigenetically activating expression of p15, p16 and p57. Moreover, knockdown of JMJD3, p15, or p16 consistently reversed the inhibitory effects of ARHGAP27P1 in cell proliferation and cell cycle progression. Low expression of ARHGAP27P1 was closely associated with advanced TNM stage, increased invasion depth and lymphatic metastasis. Low ARHGAP27P1 expression also predicted a poor prognosis in GC patients. Yes Functionally, overexpression of ARHGAP27P1 inhibited proliferation, invasion, and migration in GC cells, while silencing of ARHGAP27P1 showed the opposite effects. 31665700 ARHGAP42 LncRNA Homo sapiens Nasopharyngeal carcinoma nasopharyngeal carcinoma tissues and cell lines Regulation[PI3K/Akt signaling pathway] Transwell Assay//qRT-PCR//IHC//Western Blot We confirmed the elevated expression of ARHGAP42 in metastatic NPC tissues of mRNA and protein for the first time. Immunohistochemical analysis indicated that NPC patients with highly ARHGAP42 expression were significantly associated with shorter metastasis-free survival. Yes Knockdown of ARHGAP42 resulted in significant inhibition of nasopharyngeal cancer cell migration and invasion in vitro, and the overexpression of ARHGAP42 showed the opposite effects. 29936709 CASC15 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues Interaction[downregulate miR-124] qRT-PCR We found that CASC15 was upregulated, while miR-124 was downregulated in TSCC tissues than in non-cancer tissues of TSCC patients. CASC15 and miR-124 predict TSCC patients' survival and CASC15 may downregulate miR-124 to inhibit TSCC cell migration and invasion. Yes CASC15 overexpression resulted in the increased, while miR-124 overexpression resulted in the decreased migration and invasion rates of TSCC cells. 31665008 CASC15 LncRNA Homo sapiens Ischemic Stroke AIS patients Interaction(miR-338-3p/ETS1 Axis) Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//ELISA The expression of CASC15 was increased and the levels of miR-338-3p were decreased in AIS patients.. A positive association between CASC15 and NIHSS score and an inverse association between CASC15 and miR-338-3p were revealed by Pearson correlation. Silenced CASC15 exerted neuroprotective roles on cell viability, apoptosis, and inflammation via the miR-338-3p/ETS1 axis. A positive association between CASC15 and NIHSS score and an inverse association between CASC15 and miR-338-3p were revealed by Pearson correlation. Yes Silenced CASC15 exerted neuroprotective roles on cell viability, apoptosis, and inflammation via the miR-338-3p/ETS1 axis. 34629895 CASC15 LncRNA Homo sapiens Cholangiocarcinoma ICC tissues Regulation(PRDX2/PI3K/AKT Axis) Western Blot//Transfection//qPCR//Flow Cytometry//FISH//IF//Transwell Assay CASC15 is highly expressed in ICC tissues and is related to higher TNM stage. Downregulation of CASC15 inhibited phosphoinositide 3-kinase (PI3K)/AKT/c-Myc pathway through downregulating of PRDX2 and overexpressed PRDX2 rescued the block. CASC15 is highly expressed in ICC tissues and is related to higher TNM stage. Yes Knockdown of CASC15 in ICC cells reduced cell proliferation, migration, invasiveness and increased apoptosis, and G1/S block. PRDX2 bound to CASC15. Knockdown of CASC15 decreased PRDX2 expression which was rescued by the inhibition of proteasome formation. Downregulation of PRDX2 resulted in G1/S block, reduced ICC cell invasion. CASC15 knockout in ICC xenografts suppressed tumor development in vivo, decreased the expression of PRDX2 and Ki67 and inhibited PI3K/AKT pathway. 33017884 CASC15 LncRNA Homo sapiens Neonatal Sepsis Serum Interaction(miR-144-3p ) qRT-PCR//Transfection//ELISA//Luciferase Report Assay Serum CASC15 was upregulated in NS patients, and it had the ability to distinguish NS patients from NP patients. Besides, serum miR-144-3p was reduced in NS patients, and luciferase reporter genes showed that miR-144-3p was a direct target of CASC15. Yes LPS stimulation increased the expression of CASC15 and simultaneously stimulated the secretion of inflammatory cytokines, while the knockdown of CASC15 alleviated the inflammatory response induced by LPS stimulation. 34870560 CASC11 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[highly expressed] qRT-PCR//Transwell Assay LINC01116 and lncRNA CASC11 were both upregulated in cancer tissues compared to cancer-adjacent tissues. Expression levels of LINC01116 and CASC11 were increased with the increase in clinical stages. Yes Overexpression of LINC01116 and CASC11 led to promoted invasion and migration of gastric cancer cells. 31632064 CASC11 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues ,cell lines (A547, H157 and SPC-A-1) Regulation[microRNA-302/CDK1 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay CASC11 and CDK1 were highly expressed, whereas microRNA-302 was lowly expressed in lung cancer tissues. Identically, CASC11 was highly expressed in lung cancer cell lines (A547, H157 and SPC-A-1) than controls as well.Dual-luciferase reporter gene assay verified that CASC11 could bind to microRNA-302 and microRNA-302 could bind to CDK1. CDK1 expression in lung cancer cells was negatively regulated by CASC11. MicroRNA-302 knockdown reversed the inhibitory effect of CASC11 on CDK1 expression. The proliferation of lung cancer cells co-transfected with microRNA-302 inhibitor and si-CASC11 decreased compared with those transfected with microRNA-302 inhibitor. Yes CASC11 knockdown attenuated proliferative capacity of lung cancer cells. 31378894 CASC11 LncRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(miR-646 and miR-381-3p/RAB11FIP2 axis) CCK8//qRT-PCR//Western Blot We found that CASC11 binds to miR-646 and miR-381-3p in the cytoplasm of CRC cells.We further confirmed that RAB11FIP2 is a mutual target of miR-646 and miR-381-3p. The expression levels of CASC11 and RAB11FIP2 in CRC were positively correlated and reciprocally regulated. Further study showed that CASC11 played an important role in regulating PI3K/AKT pathway by miR-646 and miR-381-3p/RAB11FIP2 axis. Yes Moreover, miR-646 and miR-381-3p inhibitors reversed the suppressive effect of CASC11 silencing on CRC growth and metastasis in vitro and in vivo. 33937069 CASC11 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[inhibiting miRNA-188-5p] CCK8//qRT-PCR In the present study, we found that CASC11 was up-regulated, while miR-188-5p was down-regulated in tumor tissues of HCC patients.Expression levels of CASC11 and miR-188-5p were inversely correlated in tumor tissues. CASC11 overexpression mediated the down-regulation of miR-188-5p, while miR-188-5p overexpression failed to affect CASC11 expression. In addition, miR-188-5p overexpression attenuated the enhancing effects of CASC11 overexpression on cancer cell proliferation. Therefore, LncRNA CASC11 promoted cancer cell proliferation in HCC possibly by inhibiting miR-188-5p. Follow-up study showed that high levels of CASC11 were significantly correlated with poor survival. Yes CASC11 overexpression led to promoted, while miR-188-5p overexpression led to inhibited proliferation of cells of HCC cell lines. CASC11 overexpression showed no significant effects on cancer cell migration and invasion. 30910841 CASC11 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[binding with EZH2] Northern Blot//ChIP//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay//IF CASC11 was found to be overexpressed in HCC tissues and cell lines and predicted a poor prognosis.Mechanically, the enhancer of zeste homolog 2 (EZH2) was found to be a binding partner of CASC11. Moreover, CASC11 epigenetically silenced PTEN by binding with EZH2. CASC11 was found to be overexpressed in HCC tissues and cell lines and predicted a poor prognosis. Yes  Loss of CASC11 function efficiently suppressed cell migration, invasion and epithelial-mesenchymal transition (EMT).  30503497 CASC11 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(UBE2T) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay In this context, here, it was found that CASC11 was upregulated in HCC tissues and associated with tumor grades, metastasis, and prognosis of HCC patients. Mechanistically, CASC11 associated with and stabilized Ubiquitin-conjugating enzyme E2T (UBE2T) mRNA. In this context, here, it was found that CASC11 was upregulated in HCC tissues and associated with tumor grades, metastasis, and prognosis of HCC patients. Yes Functionally, CASC11 facilitated HCC cell proliferation, migration, and invasion in vitro, and enhanced tumor growth and metastasis in vivo. 34900723 CASC11 LncRNA Homo sapiens Urinary Bladder Neoplasms blood Interaction[miRNA-150 ] CCK8//qRT-PCR//Transwell Assay In this study we showed that plasma lncRNA CASC11 was upregulated.Altered expression of plasma lncRNA CASC11 and miRNA-150 separated patients with bladder cancer from healthy controls. lncRNA CASC11 expression was inversely correlated with miRNA-150 expression in patients with bladder cance but not in healthy controls. Overexpression of lncRNA CASC11 mediated the inhibition of miRNA-150 expression in cancer cells, while miRNA-150 overexpression did not significantly alter lncRNA CASC11 expression. Yes lncRNA CASC11 overexpression promoted, while miRNA-150 overexpression inhibited cancer cell proliferation. 30916832 CASC11 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines regulation[Wnt/β-catenin and JAK2/STAT3 signaling pathways] Western Blot//Flow Cytometry//qRT-PCR//BrdU//Transwell Assay CARLo-7 was dramatically upregulated in BC tissues and cell lines.Collectively, CARLo-7 plays a critical role in regulating BC development by regulating cell proliferation, migration, invasion, and EMT through Wnt/β-catenin and JAK2/STAT3 signaling. Therefore, CARLo-7 might be a promising therapeutic target for BC. Yes Silencing CARLo-7 by sh-CARLo-7 significantly suppressed proliferation and induced apoptosis of BC cells, while enforced CARLo-7 expression promoted cell proliferation. 33209690 CASC11 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues , cell lines Regulation[activating Wnt/beta-catenin signaling pathway] qRT-PCR//Luciferase Report Assay//Western Blot We discovered that CASC11, the expression of which was positively associated with the tumor size and the FIGO staging and negatively related to the patients' survival rate, was Expression[Expression[up-expression]-expression]-regulated in the cervical cancer tissues and cell lines. Yes Silencing CASC11 inhibited the proliferation, migration as well as invasion and promoted the cell apoptosis. Conversely, overexpression of CASC11 facilitated the cancer cell's proliferation, migration and invasion ability and sExpression[Expression[up-expression]-expression]pressed the apoptosis. 31255182 CASC11 LncRNA Homo sapiens Glioma glioma tissues and cells Interaction[SP1/CASC11/miR-498/FOXK1] ChIP//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this work, we found that lncRNA CASC11 was significantly up-regulated in the glioma specimens and cells, and the ectopic overexpression indicated the poor prognosis of glioma patients. Taken together, the data suggest the regulation of SP1/CASC11/miR-498/FOXK1 in the gliomagenesis, which might provide a potential therapeutic strategy for glioma. Yes In vivo and vitro, the knockdown of CASC11 impaired the proliferation, migration and tumor growth of glioma cells. 31121483 CASC11 LncRNA Homo sapiens Atherosclerosis blood Regulation[downregulating IL-9 ] qRT-PCR In the present study we found that CASC11 was downregulated, while IL-9 was upregulated in plasma of atherosclerosis patients compared with healthy controls. Therefore, CASC11 may improve atherosclerosis by downregulating IL-9 and regulating VSMC apoptosis and proliferation. Yes CASC11 overexpression also resulted in the downregulation of proliferation and promoted apoptosis of VSMC. 30915898 CASC11 LncRNA Homo sapiens esophageal carcinoma ECa tissues Interaction[regulating KLF6] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay In this work, the qPCR results showed that the expression level of lncRNA CASC11 in the ECa tissues was remarkably higher than that of the adjacent normal tissues, and the difference was statistically significant (p<0.05).The Western Blot results revealed that protein expression of KLF6 was remarkably up-regulated after lncRNA CASC11 knockdown. In addition, the recovery experiments found that lncRNA CASC11 and KLF6 had mutual regulation, thereby promoting the malignant progression of ECa. Compared with patients with a low level of lncRNA CASC11, the pathological stage of patients with high expression was significantly higher, while the overall survival rate was lower (p<0.05). Yes Compared with negative control (NC) group, the proliferation ability of the cells in the lncRNA CASC11 knockdown group CASC11 significantly decreased, whereas cell apoptosis remarkably increased (p<0.05). 31696474 CASC11 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(YBX1/p53 signaling axis) In Vivo Experiment//Wound Healing Assay//Flow Cytometry//qRT-PCR//RNA-seq The present results revealed that CASC11 was dominantly distributed in the nuclei of PCa cells, and was highly expressed in PCa tissues and cells. In conclusion, the present study suggested that CASC11 may regulate PCa progression and elucidated a novel CASC11/YBX1/p53 signaling axis, providing a potential lncRNA‑directed therapeutic strategy particularly for the treatment of patients with PCa. Yes Overexpression of CASC11 was markedly associated with increased tumor proliferation and migratory ability. Functionally, decreased proliferation and migration, as well as inhibited xenograft tumor growth, were observed in CASC11?silenced PCa cells, whereas the opposite effects were detected in CASC11?overexpressing cells. 35904175 CASC11 LncRNA Homo sapiens Small Cell Lung Carcinoma blood Interaction[TGF-β1] qRT-PCR Plasma CASC11 and TGF-β1 were upregulated and positively correlated in SCLC patients, but not in healthy controls. Overexpression of CASC11 and TGF-β1 also resulted in the increased percentage of CDD133+ cells of SCLC cell lines, while TGF-β inhibitor attenuated the effects of CASC11 overexpression. CASC11 overexpression mediated the upregulation of TGF-β1 in SCLC cells, while treatment with exogenous TGF-β1 showed no significant effect on CASC11. Upregulation of plasma CASC11 and TGF-β1 predicted poor survival of SCLC patients. Yes Overexpression of CASC11 and TGF-β1 also resulted in the increased percentage of CDD133+ cells of SCLC cell lines, while TGF-β inhibitor attenuated the effects of CASC11 overexpression. 30965130 CASC11 LncRNA Homo sapiens Pituitary Neoplasms PA tissues and cell Interaction( lncRNA MYMLR/miR-197-3p/CBR1) In Vivo Experiment//IHC//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay LncRNA MYMLR was highly expressed in PA tissues compared with that in normal tissues. Mechanistically, MYMLR functioned as a competing endogenous RNA (ceRNA) sponging microRNA miR-197-3p. Furthermore, miR-197-3p exerted its tumor inhibitory role via negatively regulating carbonyl reductase 1 (CBR1). Overexpression of CBR1 antagonized the inhibitory effect of lncRNA MYMLR knockdown or miR-197-3p overexpression. In addition, xenograft tumor model revealed that knockdown of lncRNA MYMLR suppressed PA tumor development in vivo via regulating CBR1. Yes Knockdown of MYMLR suppressed cell proliferation, migration and invasion, while promoting PA cell apoptosis. 36206098 CASC11 LncRNA Homo sapiens Neuroblastoma neonatal neuroblastoma tissues and cells Interaction[sequestered miR-676-3p] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Highly expressed CASC11 was observed in neonatal neuroblastoma tissues and cells. CASC11 sequestered miR-676-3p from NOL4L to facilitate neonatal neuroblastoma progression, hinting a CASC11-mediated therapeutic target for neonatal neuroblastoma. High level of CASC11 indicated unsatisfactory survival of neonatal neuroblastoma patients. Yes CASC11 depletion inhibited cell proliferation and invasiveness. 31645055 CASC15 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC samples and cell lines interaction[miR-33a-5p] qRT-PCR//Western Blot Here, we identified that CASC15 expression was upregulated in TSCC samples and cell lines. These results suggested that lncRNA CASC15 and miR-33a-5p might be exploited as new markers of TSCC and were potential treatment targets for TSCC patients. Yes We showed that overexpression of CASC15 promoted cell proliferation, cycle, and migration in TSCC. 29804249 CASC15 LncRNA Homo sapiens Melanoma melanoma tissues and cells Regulation[Wnt/β-Catenin Signaling Pathway] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The expression of CASC15 and β-catenin was upregulated in melanoma tissues and cells. Our study demonstrated that CASC15 promoted the proliferation, migration, and invasion of melanoma cells via activating Wnt/β-catenin signaling pathway, implying that CASC15 might be a potential therapeutic target and prognostic biomarker for melanoma. Yes Furthermore, inhibition of CASC15 decreased proliferation and increased apoptosis of melanoma cells by downregulating Survivin and Bcl-2 and upregulating Bax in A375 and SK-MEL-28 cells. Silencing of CASC15 inhibited migration and invasion of melanoma cells by repressing EMT process. 31838468 CARMN miRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation[Wnt signaling pathway] Western Blot//qPCR//CCK8//PCR//IF miR143HG expression was markedly downregulated in HCC tissues and cells.miR143HG inhibits miR-155 expression; miR-155 directly targets APC, which is a negative regulator of the Wnt/β-catenin pathway, so miR143HG can act on the Wnt pathway. miR143HG was further found to reduce the expression of β-catenin and block the nuclear accumulation of β-catenin, ultimately inhibiting the activation of the Wnt pathway. It inhibits the expression of Wnt downstream target gene ZEB1, and then E-cadherin expression is increased and cell motility is inhibited. Furthermore, miR143HG exerts its antiproliferative function by influencing the MAPK signaling pathway and then inducing G2 /M arrest in cells. Additionally, miR143HG expression predicted a good prognosis and acted as an independent prognostic factor in HCC for overall survival. Yes Overexpression of miR143HG suppressed HCC cell proliferation and metastasis, and induced cell cycle arrest and apoptosis. Consistently, the depletion of miR143HG resulted in the opposite phenomenon of the aforementioned results. 30945380 CASC15 LncRNA Homo sapiens Melanoma melanoma tissues interaction[PDCD4] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//cell invasion assay//Cell Cycle Assay We found that CASC15 expression was up-regulated in melanoma tissues and associated with advanced pathological stages. CASC15 acts as an oncogene by negatively regulating PDCD4 expression via recruiting EZH2 and subsequently increasing H3K27me3 level. Yes Function experiments displayed that CASC15 knockdown hindered proliferation, facilitated apoptosis and suppressed invasion, while CASC15 overexpression facilitated proliferation and invasion in melanoma cells. 30013768 CASC19 LncRNA Homo sapiens Osteoarthritis OA tissues and cells Interaction(miR-152-3p/DDX6 axis) CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA CASC19 was verified to exhibit higher expression in OA tissues and cells. Moreover, inhibition of CASC19 weakened proinflammatory cytokine (IL-6, IL-8, and TNF-α) production and cell apoptosis but facilitated cell viability. Experiments of the ceRNA mechanism elucidated that miR-152-3p was a sponge for CASC19, and miR-152-3p targeted DDX6, suggesting that CASC19 sponged miR-152-3p to release DDX6. Finally, results from rescue assays proved that the impacts of CASC19 silencing on chondrocytes apoptosis and proinflammatory cytokine production could be reversed by DDX6 overexpression. Yes CASC19 was verified to exhibit higher expression in OA tissues and cells.Finally, results from rescue assays proved that the impacts of CASC19 silencing on chondrocytes apoptosis and proinflammatory cytokine production could be reversed by DDX6 overexpression. 34158095 CASC19 LncRNA Homo sapiens Glioma glioma tissues and cell lines regulation[miR-454-3p/RAB5A axis ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU//Transwell Assay The results revealed that CASC19 expression was significantly upregulated in glioma tissues and cell lines. The results demonstrated that the CASC19/miR‑454‑3p/RAB5A axis is involved in the promotion of glioma progression. CASC19 expression was also positively associated with tumor diameter and pathological grade. Additionally, its high expression was closely associated with tumor MRI signal heterogeneity and peritumoral edema. Yes CASC19 upregulation promoted glioma cell proliferation and metastasis, while CASC19?knockdown demonstrated the opposite effect. 33416169 CASC19 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines regulation[miR-148b/E2F7 axis] qRT-PCR//MTT//Tunel//Transwell Assay The results elucidated that CASC19 expression was markedly increased in PC tissues and cell lines. The CASC19/miR-148b/E2F7 axis might be a new study direction for PC treatment. Patients with high expression of CASC19 had a short survival time. Yes Silencing of CASC19 attenuated PC cell proliferation, migration, and invasion. 33155202 CASC19 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cell lines regulation[CASC19/miR-532/ETS1 regulatory pathway] qRT-PCR//MTT//Colony Formation Assay CASC19 was overexpressed in ccRCC tissues and cell lines.The CASC19/miR-532/ETS1 regulatory pathway is crucial for the malignant manifestations of ccRCC, which makes it an attractive target for potential treatments of ccRCC. High expression of CASC19 was closely associated with unfavorable clinicopathological parameters and predicted negative clinical outcomes in patients with ccRCC. Yes Knockdown of CASC19 decreased ccRCC cell proliferation, colony formation, migration, and invasiveness, as well as attenuated tumor growth in vivo. 32273759 CASC19 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction[regulating miRNA-130b-3p] qRT-PCR//Luciferase Report Assay LncRNA CASC19 was upregulated in NSCLC tissues and cell lines. NSCLC patients with high expression of CASC19 presented a worse survival. NSCLC patients with high expression of CASC19 presented a worse survival. Yes Knockdown of CASC19 attenuated proliferative, migratory, and invasive capacities of A549 and PC9 cells. CASC19 sponged miRNA-130b-3p and negatively regulated its level. 31389608 CASC15 LncRNA Homo sapiens Breast Neoplasms breast cancer tissue specimens and cells Regulation[miR-153-3p/KLF5 positive feedback loop] ChIP//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay This study uncovered that CASC15 expression level was aberrantly high-expressed in breast cancer tissue specimens and cells. In conclusion, we validated the positive feedback loop of KLF5/CASC15/miR-153-3p/KLF5 in the acceleration of breast cancer malignant behaviors and tumorigenesis, suggesting the important biologic roles of CASC15 on the breast cancer tumorigenesis. Yes Functionally, the loss-of-functional experiments showed that knockdown of CASC15 suppressed the malignant behaviors of breast cancer cells, such as proliferation, invasion and tumor growth in vitro and vivo. 30389133 CASC15 LncRNA Homo sapiens Breast Neoplasms MCF-7 cells Interaction(miR-654-5p/MEF2D axis) qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Western Blot In this study, high expression of CASC15 in MCF-7 CSCs was reported, relative to MCF-7 cells, and this phenomenon was associated with metastatic lymph nodes, higher TNM stage, and shorter breast cancer survival rates. Overall, breast cancer stemness and tumor development are regulated via the CASC15/miR-654-5p/MEF2D axis. Accordingly, this pathway can be explored for breast cancer therapy. miR-654-5p/MEF2D axis Yes Further experiments revealed that CASC15 promoted the acquisition of stemness properties of breast cancer cells (BSCCs) by competing with endogenous RNA for miR-654-5p, resulting in overexpression of MEF2D in BCSCs. 35235236 CASC15 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues regulation[ SIM2 stability] Flow Cytometry//qRT-PCR//MTT//Western Blot The results revealed that CASC15 expression was elevated in ESCC tissues, and patients with ESCC exhibiting high CASC15 expression had a poor prognosis. In conclusion, CASC15 promoted ESCC tumorigenesis by decreasing SIM2 stability via FTO‑mediated demethylation. The results revealed that CASC15 expression was elevated in ESCC tissues, and patients with ESCC exhibiting high CASC15 expression had a poor prognosis. Yes CASC15?knockdown inhibited ESCC cell proliferation and facilitated apoptosis. Additionally, CASC15?knockdown decreased the growth of ESCC xenograft tumors. 33650646 CASC15 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Interaction(miR-33a-5p/PTGS2 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay CASC15 was upregulated in ESCC tissues and cell lines. Mechanistically, it was confirmed that CASC15 acts as competing endogenous RNA for miR-33a-5p to regulate PTGS2 expression. In addition, rescue assay showed that miR-33a-5p knockdown or PTGS2 overexpression abolished the cell proliferation, migration, and invasion inhibition role of CASC15 knockdown. CASC15 overexpression was associated with poorer prognosis in ESCC patients. Yes Functionally, CASC15 knockdown inhibited cell proliferation, migration, and invasion of ESCC cells. 36111503 CASC15 LncRNA Homo sapiens Lung Neoplasms lung cancer tissue and cells Regulation[miR-766-5p/ KLK12 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In lung cancer tissue and cells, CASC15 was upregulated, while miR-766-5p was downregulated. CASC15 promotes lung cancer through the miR-766-5p/KLK12 axis, indicating that CASC15 is a potential therapeutic in lung cancer. Yes Overexpression of CASC15 promoted lung cancer cell proliferation and invasion. 31378128 CASC15 LncRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(miR-582-5p/HMGB2) qRT-PCR//RNA Pull-Down//RIP//Transwell Assay The CASC15 level is revealed to be significantly elevated in CRC cells compared to that in normal cells. Furthermore, CASC15 can bind with microRNA-582-5p (miR-582-5p) to modulate high mobility group box 2 (HMGB2) expression. We also showed that silencing of CASC15 inhibits tumor growth. Yes In vitro assays revealed that CASC15 overexpression stimulates cell growth and invasion, whereas its down-expression has opposite effects. 33395735 CASC15 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Interaction(miR-7151-5p/WNT7A axis) qRT-PCR//Colony Formation Assay//Western Blot The present study results showed that CASC15 was overexpressed in PTC tissues compared with normal tissues and acted as a potent oncogene to promote the proliferation and tumorigenesis of PTC cells both in vitro and in vivo. Mechanistic studies demonstrated that CASC15 could serve as an endogenous miRNA sponge to absorb and downregulate miR-7151-5p, thereby preventing the inhibition of WNT7A during PTC progression. Furthermore, the study demonstrated that CASC15 activated the WNT/β‑catenin signaling pathway by upregulating WNT7A in PTC. Yes The present study results showed that CASC15 was overexpressed in PTC tissues compared with normal tissues and acted as a potent oncogene to promote the proliferation and tumorigenesis of PTC cells both in vitro and in vivo. 34325316 CASC15 LncRNA Homo sapiens Ovarian Neoplasms Ovarian Cancer tissues Regulation[miR-221/ARID1A Axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, we found that the expression of CASC15 was lower in ovarian cancer tissues and cells by qRT-PCR.In addition, bioinformatics analysis, luciferase reporter assay, and biotin pull-Expression[down-expression] assay confirmed that CASC15 straightly interacted with miR-221. In addition, low expression of CASC15 was closely correlated with advanced TNM stage, moderate/poor differentiation, and larger size. Moreover, Kaplan-Meier survival analysis showed that patients with low CASC15 expression level had poorer overall survival and progression-free survival than those with high CASC15 expression. Yes Overexpression of CASC15 prohibited the malignancy of ovarian cancer cells, including proliferation, colony formation, cell cycle, migration, and invasion, and promoted cell apoptosis. 31695430 CASC15 LncRNA Homo sapiens Ovarian Neoplasms OC cells Interaction( miR-23b-3p/miR-24-3p/SMAD3) qRT-PCR//Luciferase Report Assay//Western Blot In vitro and in vivo experiments validated CASC15 as an oncogenic lncRNA in ovarian cancer, which could enhance metastasis through TGF-β-induced epithelial-mesenchymal transition progress. MiR-23b-3p and miR-24-3p, which are members of the miR-23b cluster, were identified to directly target CASC15 through luciferase assays. Further mechanistic investigations indicated that CASC15-mediated miR-23b-3p/miR-24-3p sequestration cooperatively upregulated SMAD3 expression, which, in turn, would permit increased CASC15 mRNA level as a transcription activation factor. Yes In vitro and in vivo experiments validated CASC15 as an oncogenic lncRNA in ovarian cancer, which could enhance metastasis through TGF-β-induced epithelial-mesenchymal transition progress. MiR-23b-3p and miR-24-3p, which are members of the miR-23b cluster, were identified to directly target CASC15 through luciferase assays. Further mechanistic investigations indicated that CASC15-mediated miR-23b-3p/miR-24-3p sequestration cooperatively upregulated SMAD3 expression, which, in turn, would permit increased CASC15 mRNA level as a transcription activation factor. 35342355 CASC15 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines,blood regulation[miR-338-3p/RAB14 axis ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Upregulated CASC15 was observed in OS plasma exosomes compared with control, and the same expression was observed in the OS tissues and cell lines. Overall, our findings indicate that CASC15 plays a key role in OS progression by targeting the miR-338-3p/RAB14 axis and can serve as a possible therapeutic target for OS patients. Yes Further assays indicated that CASC15 knockdown could restrain the proliferation, migration, and invasion of OS cells, and inhibit the growth of OS in xenograft models. 33262606 CASC15 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and adjacent tissues,cell lines(g HeLa, Caski and C33A) Expression[Expression[Expression[highly expressed]-expression]-expression] CCK8//qRT-PCR//Western Blot We demonstrated that lncRNA CASC15 expression was higher in cervical cancer tissues compared to adjacent normal tissues. "By Chi-square test, we found that higher lncRNA CASC15 expression associated with lymph node metastasis and FIGO stage (All of p<0.05, Table I). Moreover, survival plots results showed that higher lncRNA CASC15 expression predicted a poor prognosis of cervi_x0002_cal cancer compared to lower lncRNA CASC15 expression in cervical cancer patients (Figure 1C, log rank test, p<0.05). Thus, these results indicated that higher lncRNA CASC15 expression showed an important role in cervical cancer." Yes Functional assays showed that knockExpression[down-expression] of lncRNA CASC15 sExpression[Expression[up-expression]-expression]pressed cell proliferation and cell cycle progression in cervical cancer. Moreover, we also found that knockExpression[down-expression] of lncRNA CASC15 inhibited cell invasion ability and Epithelial-Mesenchymal Transition (EMT) signaling pathway by Expression[Expression[up-expression]-expression]regulating E-cadherin and Expression[down-expression]regulating N-cadherin expression in cervical cancer. 30720157 CASC15 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cells Interaction(miR-365/cyclin D1) Cell Proliferation Assay//qRT-PCR//Western Blot CASC15 was upregulated in LSCC and high expression levels of CASC15 predicted poor survival. In LSCC tissues, CASC15 was negatively correlated with miR-365 but positively correlated with cyclin D1. In LSCC cells, overexpression of CASC15 resulted in downregulation of miR-365 and upregulation of cyclin D1. Overexpression of miR-365 did not affect the expression of CASC15 but downregulated cyclin D1. Overexpression of Cyclin D1 did not affect the expression of miR-365 and CASC15. CASC15 was upregulated in LSCC and high expression levels of CASC15 predicted poor survival. Yes Overexpression of CASC15 and cyclin D1 led to promoted, while overexpression of miR-365 led to inhibited LSCC cell proliferation. In addition, overexpression of miR-365 reduced the effects of overexpression of CASC15. 35216636 CARMN-208 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues,cell lines Expression[lower expressed] qRT-PCR//RNA-seq Subsequently, four lncRNAs (upregulated ENST00000433108; downregulated ENST00000598996, ENST00000524265 and ENST00000398461) and two mRNAs (upregulated CCNB1 and CDK1) in 64 pairs of BC and adjacent normal tissues and four BC cell lines were detected using reverse transcription?quantitative PCR and these results were consistent with the sequencing data. The low expression level of ENST00000598996 and ENST00000524265 was correlated with unfavorable clinicopathological parameters, and shorter progression?free and overall survival time, whereas, ENST00000433108 was not associated with either. Yes The in vitro functional experiments also revealed that the overexpression of ENST00000598996 and ENST00000524265 decreased the proliferation, migration, and invasion abilities of BC cells. 33000254 CARMN LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Regulation[miR-1275/AXIN2 axis] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay In the present study, we found that miR143HG expression was significantly downregulated in bladder cancer tissues (BCa) compared with normal tissues. In summary, our findings demonstrated that miR143HG/miR-1275/AXIN2 axis regulates BCa development by modulating the Wnt/β-catenin pathway. We showed that miR143HG high expression was associated with a high survival rate in BCa patients. Yes Gain-of-function assays demonstrated that miR143HG overexpression suppressed the proliferation, arrested cell cycle progression, and attenuated migration and invasion of BCa cells in vitro. In vivo assay illustrated that ectopic expression of miR143HG inhibited BCa growth in vivo. 30471109 ZSCAN16-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction( miR-181 c-5p/SPAG9 axis/JNK pathway) qRT-PCR ZSCAN16-AS1 was significantly up-regulated in HCC cells. ZSCAN16-AS1 worked as a competing endogenous RNA (ceRNA) to regulate sperm associated antigen 9 (SPAG9) expression through sponging miR-181 c-5p. Moreover, SPAG9 could activate the c-Jun-N-terminal kinase (JNK) pathway. Yes ZSCAN16-AS1 silence inhibited HCC cell proliferation, migration and invasion, while it accelerated HCC cell apoptosis. 34097562 CA3-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer cell lines and tissues Interaction(miR-93-5p/BTG3) qRT-PCR//Luciferase Report Assay//Western Blot//Transwell Assay Firstly, we found that the expression level of CA3-AS1 was decreased in gastric cancer cell lines and tissues. Then, the relationship between CA3-AS1 and miR-93-5p was explored. Luciferase reporter assays results showed that miR-93-5p was a direct target of CA3-AS1 in SGC-7901 and BCG-823. Furthermore, BTG3 was identified as a direct target gene of miR-93-5p. Restore experiments showed that CA3-AS1 upregulated the expression level of BTG3 and inhibited the gastric cancer cells invasion by sponging miR-93-5p. Yes Then, CA3-AS1 overexpression inhibited the gastric cancer cells migration and invasion and knockdown of CA3-AS1 enhanced the gastric cancer cells migration and invasion. Finally, we found that CA3-AS1 inhibited the metastasis ability of gastric cancer cells in vivo. 33051589 C3orf85 LncRNA Homo sapiens Stomach Neoplasms GC tissues and their adjacent tissues Expression[lower expressed] CCK8//qRT-PCR//Western Blot//Microarray The lncRNA FLJ22763 was found to be significantly downregulated with the largest fold change Yes The ectopic expression of lncRNA FLJ22763 significantly suppressed the biological malignant behavior of GC cells and inhibited xenograft tumor growth (both P < 0.001). 30716442 C2dat2 LncRNA Homo sapiens Cerebral Ischaemia/Reperfusion Injury cell lines Interaction(miR-30d-5p/DDIT4/mTOR axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Tunel//qRT-PCR//FISH//Luciferase Report Assay//Bioinformatics Analysis Mechanistically, C2dat2 acts as a competing endogenous RNA (ceRNA) to negatively regulate miR-30d-5p expression. More specifically, miR-30d-5p targeted the 3'-untranslated region of DNA damage-inducible transcript 4 (DDIT4) and silenced its target mRNA DDIT4. Additionally, C2dat2 binding with heat shock cognate 70/heat shock protein 90 blocked RNA-induced silencing complex assembly to abolish the miR-30d-5p targeting of DDIT4 and inhibited miR-30d-5p to silence its target mRNA DDIT4. Further analysis showed that C2dat2 knockdown conspicuously inhibited the up-regulation of DDIT4 and Beclin-1 levels and LC3B II/I ratio and the down-regulation of P62 and phosphorylated mammalian target of rapamycin (mTOR)/mTOR and phosphorylated-P70S6K/P70S6K ratio in Neuro-2a cells after oxygen-glucose deprivation/reoxygenation. Yes C2dat2 up-regulation facilitated neuronal autophagy and apoptosis induced by CIRI. 33833132 C2CD4D-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines. Interaction(miR-3681-3p/NEK2 axis) RNA Pull-Down//ChIP//Western Blot//Transfection//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay C2CD4D-AS1 was dramatically overexpressed in LUAD tissues and cell lines. To conclude, C2CD4D-AS1 up-regulation induced by ETV4 enhanced NEK2 expression by sequestering miR-3681-3p to contribute to the malignant behaviors of LUAD cells. Yes As a result, depletion of C2CD4D-AS1 significantly repressed cell proliferation, migration, invasion and stimulated cell apoptosis in LUAD. 34850664 C20orf204-203 LncRNA Homo sapiens Hematologic Neoplasms leukemia cell lines and THP-1 cell line Regulation RNA-seq Here, we used short hairpin RNA (shRNA) library combined with high-throughput sequencing to screen lncRNAs that may affect the proliferation of leukemia cell lines, and identified lncRNA C20orf204-203 among 74 candidate lncRNAs in this study. We observed the increased mRNA level of BAD gene while decreased protein level of TP53 and BCL2. The expression of Caspase 3 decreased and Caspase 3-cleaved protein increased in THP-1 cell line. However, their changes were inconsistent in the two cell lines. Yes C20orf204-203 knockdown decreased the proliferation of K562 and THP-1 cell lines accompanied with the increased proportion of early apoptotic cells. Our experimental results showed that knockdown of lncRNA C20orf204-203 in leukemia cell lines affected cell proliferation although the mechanism of action in different cell lines may differ. 36151809 C20orf204 LncRNA Homo sapiens Carcinoma, Hepatocellular 20 primary HCC Expression(highly expressed) qRT-PCR We report here that a protein, C20orf204-189AA, was detected in the nucleus of 14 out of 20 primary HCC, but not in control livers. Furthermore, the expression of C20orf204-189AA upregulates the protein level of nucleolin. Nucleolin and C20orf204 mRNA levels in HCC are correlated with tumor differentiation grade and patient survival, suggesting that C20orf204-189AA is a cancer type-specific fine tuner in some HCC that presents itself for potential targeting therapy and cancer biomarker. Yes Strikingly, overexpression of C20orf204-189AA enhanced cell proliferation and ribosomal RNA transcription. 33731669 C20orf204 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues,cell lines Regulation[LINC00176/BCL3/CP axis] qRT-PCR Bioinformatics prediction in combination with RT-qPCR analysis for the expression pattern of LINC00176 revealed that LINC00176 was highly expressed in ovarian cancer tissues as well as in ovarian cancer cell lines, respectively. Investigations with regard to the correlation between LINC00176 and promoter region of CP turned out to be positive via B-cell CLL/lymphoma 3 (BCL3) by means of dual-luciferase reporter gene assay, ChIP and RIP assays. Furthermore, oncogenic properties of the LINC00176/BCL3/CP axis were also demonstrated by tumour formation in vivo generated upon injecting cells in nude mice. Our results demonstrate that restored LINC00176 initiates tumorigenesis in ovarian cancer by increasing CP expression via recruiting BCL3, the mechanism of which represented a potential and promising therapeutic target for the disease. Yes Promoted proliferation, migration and invasion along with reduced apoptosis were observed in cells treated with oe-LINC00176, while si-BCL3 and si-CP were able to block the promoting effects. 31668012 C1RL-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[AKT/β-Catenin/c-Myc Pathway] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay C1RL-AS1 was upregulated in GC tissues, and high expression levels of C1RL-AS1 were associated with poor prognosis.C1RL-AS1 probably exerts its biological function by mediating the AKT/β-catenin/c-Myc pathway, indicating a novel therapeutic target in GC. C1RL-AS1 was upregulated in GC tissues, and high expression levels of C1RL-AS1 were associated with poor prognosis. Yes Further in vitro functional assays revealed that silencing C1RL-AS1 attenuated the proliferation rate and migration ability and enhanced the apoptotic rate and the senescence of GC cells. 32983994 C10orf95-AS1 LncRNA Homo sapiens Colonic Neoplasms CRC tissues and multiple CRC cell lines Interaction(miR125a-5p Axis) CCK8//qRT-PCR In the study, we found that the expression of RPARP-AS1 was significantly up-regulated in CRC tissues and multiple CRC cell lines, which was closely related to poor prognosis of CRC patients.Results of research on the mechanisms showed that RPARP-AS1 functioned as a competitive endogenous RNA (ceRNA) to sponge miR-125a-5p, therefore promoting CRC procession. In the study, we found that the expression of RPARP-AS1 was significantly up-regulated in CRC tissues and multiple CRC cell lines, which was closely related to poor prognosis of CRC patients. Yes Loss-of-function studies indicated that knockdown of RPARP-AS1 inhibited CRC cell proliferation, migration and invasion in HCT116 and LoVo cell lines. 34675548 BX357664 LncRNA Homo sapiens Stomach Neoplasms cancer specimens Interaction( miR-183-3p/PTEN/PI3K/AKT pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Invasion Assay It was found that BX357664 level was lowered in cancer specimens than adjacent non-cancer tissues and correlated with tumor size and TNM stage. In the dual-luciferase report analysis, BX357664 acted as a miR-183-3p ceRNA to target and regulate the expression of PTEN and affect the PI3K/AKT pathway. It was found that BX357664 level was lowered in cancer specimens than adjacent non-cancer tissues and correlated with tumor size and TNM stage. Yes Also, we used cell counting kit 8 (CCK8), cell clone formation assay and transwell assay, which affirmed that up-regulation of BX357664 inhibited the proliferation, migration, and invasion of GC cells, but promoted apoptosis. 33607219 BX357664 LncRNA Homo sapiens Lung Neoplasms Tumor tissues and their adjacent non-cancerous tissues,cell lines(A549，H1975,H-125,95D,SPC-A-1,293T) Expression[lower expressed] Wound Healing Assay//CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay In the present study, it was initially demonstrated that BX357664 was downregulated in clinical lung cancer tissues and in a series of lung cancer cell lines. Yes Transwell analysis and a wound-healing assay also demonstrated that overexpression of BX357664 in A549 and 95D cells significantly inhibited cell migration and invasion. 30854036 BX357664 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cell lines Expression[lower expressed] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Transwell Assay The results demonstrated that BX357664 was significantly downregulated in clinical colorectal cancer tissues and cell lines. Yes Overexpression of BX357664 decreased cell proliferation rates and cell colony formation capacities in HCT116 and HT-29 cells. 29844809 BTN3A2 LncRNA Homo sapiens Bacterial Infections cecum tissue and DF-1 cells Expression(highly expressed) In Vivo Experiment//qRT-PCR//ELISA//RNA-seq Moreover, through cis regulation network analysis of the differentially expressed lncRNAs, we found that a novel lncRNA termed lncRNA BTN3A2 was significantly increased in both cecum tissue and DF-1 cells after coccidia infection or sporozoite stimulation. Yes Functional test data showed that the overexpression of lncRNA BTN3A2 reduced the production of inflammatory cytokines, including IL-6, IL-1β, TNF-α and IL-8, while lncRNA BTN3A2 knockdown promoted the production of these inflammatory cytokines. 36091044 BTG3-7:1 LncRNA Homo sapiens Triple Negative Breast Neoplasms regulation[GRB2-RAS-RAF-MEK-ERK and GRB2-PI3K-AKT-GSK3β-β-catenin pathways] Flow Cytometry//FISH//Western Blot Abundant Lnc-BTG3-7:1, which targets gene C21ORF91, was specifically observed in TNBC biopsies and cell lines.Meanwhile, investigation of molecular mechanism indicated that Lnc-BTG3-7:1, cooperated with transcription factor JUND, cis-regulated the transcription of C21ORF91 gene, and down-regulation of Lnc-BTG3-7:1/C21ORF91 suppressed GRB2-RAS-RAF-MEK-ERK and GRB2-PI3K-AKT-GSK3β-β-catenin pathways. Yes Knockdown of Lnc-BTG3-7:1 or C21ORF91 strongly inhibited cell proliferation, promoted cell apoptosis and cell cycle G1-arrested. 33585557 BTG2 LncRNA Homo sapiens Glioma RBP-J OE Mφ-Exos Interaction(miR-25-3p/PTEN) In Vivo Experiment//cell invasion assay//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Microarray//Cell Proliferation Assay We found that circRNA BTG (circBTG2) is upregulated in RBP-J OE Mφ-Exos compared to WT Mφ-Exos. In conclusions, Exo-circBTG2 secreted from RBP-J OE Mφ inhibits tumor progression through the circBTG2/miR-25-3p/PTEN pathway, and circBTG2 is probably a diagnostic biomarker and potential target for glioma therapy. Yes RBP-J OE Mφ-Exos co-culture and circBTG2 overexpression inhibited proliferation and invasion of glioma cells, whereas circBTG2 knockdown promotes tumor growth in vivo. The effects of RBP-J OE Mφ-Exos on glioma cells can be reversed by the circBTG2 knockdown. 35643814 BSN-DT LncRNA Homo sapiens Osteosarcoma OS cells regulation[miR-654-3p/SYTL2 axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP Our study identified that BSN-AS2 expression was boosted in spinal OS tissues and cell lines. In conclusion, the availability of miR-654-3p was antagonized by E2F1-induced BSN-AS2 for SYTL2-meidated spinal OS progression. Yes Afterwards, loss-of-function assays indicated that BSN-AS2 depletion reduced cell proliferation, migration and invasion as well as promoted cell apoptosis in spinal OS. 32351327 BSG-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular tissues with high hypoxia score. Regulation(BSG ) qRT-PCR//RNA Pull-Down//Western Blot We found that lncRNA BSG-AS1 was highly expressed in tissues with high hypoxia score. RNA-seq was used to find the downstream target genes of lncRNA BSG-AS1. Sequencing data and wet experiments showed that mRNA of BSG decreased after knockout of lncRNA BSG-AS1, and mediated the promotive effect of lncRNA BSG-AS1 on proliferation and migration in HCC cells. Yes Then we verified the response of lncRNA BSG-AS1 to hypoxia in the cell hypoxia model in vitro. Through functional phenotypic analysis, we found that lncRNA BSG-AS1 can mediate the promoting effect of hypoxia on the proliferation and migration in HCC cells. 34119821 BRE-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation[NR4A3] RNA Pull-Down//Western Blot//RIP//qRT-PCR//EdU Staining//ChIP In this study, using public NSCLC microarray data we identified a novel lncRNA BRE antisense RNA 1 (BRE-AS1). BRE-AS1 is significantly down-regulated in NSCLC tissues and cell lines. Collectively, our data demonstrate that BRE-AS1 represses NSCLC cell growth and survival via up-regulating NR4A3 and suggest that enhancing BRE-AS1 may be potential therapeutic strategy for NSCLC. Yes Gain-of-function and loss-of-function assays showed that BRE-AS1 reduces NSCLC cell viability, represses NSCLC cell proliferation, and induces NSCLC cell apoptosis in vitro, and represses NSCLC tumor growth in vivo. 30227111 BRE-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues regulation[ mediating STAT3] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay LncRNA BRE-AS1 showed significantly decreased expression in BC tissues than the paired normal tissues.Over-expression of lncRNA BRE-AS1 inhibited BC cell proliferation in vitro and in vivo via repressing the phosphorylation of STAT3. Yes In vitro experiments demonstrated that over-expression of lncRNA BRE-AS1 inhibited cell proliferation but promoted cell apoptosis of EJ and T24 cells. STAT3 was determined as a target for lncRNA BRE-AS1. In vivo, up-regulation of lncRNA BRE-AS1 reduced cancer growth in nude mice bearing BC via repressing the phosphorylation of STAT3. 32495865 CA3-AS1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues,cell lines(HCT-116，SW480，SW620，SW1116,HT29) Regulation[miRNA-93/PTEN axis] CCK8//qRT-PCR//Transwell Assay//Western Blot We found that lncRNA CA3-AS1 mainly located in cytoplasm, and overexpression of lncRNA CA3-AS1 inhibits cell proliferation, invasion and promotes cell apoptosis. Our results revealed that miR-93 could directly bind to CA3-AS1, and verified the oncogenic role of miR-93. Furthermore, we found that miR-93 played its role through regulating PTEN, the tumor-sExpression[Expression[up-expression]-expression]pressor gene, which was inversely correlated with miR-93. Yes We found that lncRNA CA3-AS1 mainly located in cytoplasm, and overexpression of lncRNA CA3-AS1 inhibits cell proliferation, invasion and promotes cell apoptosis. Our results revealed that miR-93 could directly bind to CA3-AS1, and verified the oncogenic role of miR-93. Furthermore, we found that miR-93 played its role through regulating PTEN, the tumor-sExpression[Expression[up-expression]-expression]pressor gene, which was inversely correlated with miR-93. 30415006 CARMN LncRNA Homo sapiens Endometrial Neoplasms EC tissues Interaction[sponging miR-125a ] qRT-PCR//Cell Apoptosis Assay//Western Blot We found that the down-regulation of miR143HG in EC predicted poor survival.MiR143HG may up-regulate p53 in EC by sponging miR-125a to promote cancer cell apoptosis. We found that the down-regulation of miR143HG in EC predicted poor survival. Yes Cell apoptosis analysis showed that miR143HG and p53 over-expression led to an increased cell apoptotic rate. 31819644 CACNA1C-AS2 LncRNA Homo sapiens Glioma glioma cells Regulation(Fbxo45) In Vivo Experiment//Western Blot//Wound Healing Assay//Tunel//Migration Assay//qRT-PCR//MTT//Invasion Assay//Transwell Assay In the current study, we discovered that an antisense lncRNA, CACNA1C-AS2, suppressed growth, migration and invasion of glioma cells, suggesting that CACNA1C-AS2 functions as a tumor suppressor.Furthermore, we found that CACNA1C-AS2 negatively regulated Fbxo45 protein expression in glioma cells. Yes In the current study, we discovered that an antisense lncRNA, CACNA1C-AS2, suppressed growth, migration and invasion of glioma cells, suggesting that CACNA1C-AS2 functions as a tumor suppressor. 36038736 CARMN LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(miR-92a-3p/BTG2/Wnt/β-catenin axis) Flow Cytometry//qRT-PCR//MTT//Transwell Assay RT-qPCR and clinical analysis revealed that CARMN and B-cell translocation gene 2 (BTG2) were downregulated, whereas miR-92a-3p was upregulated in CC tissues and cells and their expressions were correlated with clinicopathological characteristics and prognosis. Mechanically, CARMN repressed miR-92a-3p to promote BTG2 transcription. Functional rescue assays revealed that miR-92a-3p overexpression or BTG2 downregulation reversed the inhibitory role of CARMN overexpression in CC cell growth. Western blot analysis elicited that Wnt3a and β-catenin were elevated in CC cells and CARMN blocked the Wnt/β-catenin signaling pathway via the miR-92a-3p/BTG2 axis. RT-qPCR and clinical analysis revealed that CARMN and B-cell translocation gene 2 (BTG2) were downregulated, whereas miR-92a-3p was upregulated in CC tissues and cells and their expressions were correlated with clinicopathological characteristics and prognosis. Yes MTT assay, flow cytometry, and Transwell assays revealed that CARMN overexpression reduced proliferation, migration, and invasion and increased apoptosis rate in CC cells. 36314369 CARMN LncRNA Homo sapiens Glioblastoma GBM tissues Interaction(miR-504/p53 ) Cell Proliferation Assay//qRT-PCR//Western Blot We found that miR143HG was downregulated in GBM and predicted poor survival. We found that miR143HG was downregulated in GBM and predicted poor survival. The mRNA expression levels of miR143HG and p53 were positively correlated in GBM tissues.Bioinformatics analysis suggested that miR143HG could form base paring with miR-504, which has been reported to target p53. Yes Moreover, overexpression of miR143HG and p53 decreased GBM cell proliferation, while overexpression of miR-504 increased GBM cell proliferation. In addition, overexpression of miR-504 attenuated the effect of miR143HG overexpression on GBM cell proliferation. 33461388 CARMN LncRNA Homo sapiens Triple Negative Breast Neoplasms breast tissue Interaction(miR143-3p/MCM5) Cell Proliferation Assay//qRT-PCR//Western Blot CARMN is downregulated at different phase of malignant transformation of breast tissue. We confirmed CARMN can produce miR143-3p from its exon5 which is DROSHA and DICER dependent, resulting binding and decrease of MCM5. CARMN can predict both better prognosis and higher response rate of cisplatin-based neoadjuvant chemotherapy in breast cancer. Yes Through in vitro and in vivo studies, we confirmed CARMN can also inhibit tumorigenesis and enhance sensitivity to cisplatin in TNBC cells. 34162418 CARD8-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung tissues and cell lines Interaction(miR-650) Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay The expression of CARD8-AS1 was decreased in lung adenocarcinoma tissues and cell lines (p < 0.001). The Bcl-2 protein levels were decreased while Bax levels were increased by overexpression of CARD8-AS1 (p < 0.001). miR-650 may thus be a direct target of CARD8-AS1 and Bax may be a direct target of miR-650. Low expression of CARD8-AS1 was related to tumor size (p = 0.042), TNM stage (p = 0.021), lymph node metastasis (p = 0.025), and poor overall survival (p < 0.05). Yes Elevated expression of CARD8-AS1 could suppress cellular viability, migration potential, and invasion ability (p < 0.05). 35996500 CARD11 LncRNA Homo sapiens Uveal melanoma immune cells Expression(highly expressed) qRT-PCR CARD11 expression had notable correlation with UVM clinicopathological features, which was also an independent predictor for overall survival (OS). Intriguingly, CARD11 had a positively correlation to autophagy, cellular senescence and apoptosis. Infiltration of monocytes was significantly higher in low CARD11 expression group, and infiltration of T cells regulatory was lower in the same group. Functional enrichment analyses revealed that CARD11 was positively related to T cell activation pathways and cell adhesion molecules. The expressions of hub-genes were all increased in the high CARD11 expression group and the ceRNA network showed the interaction among mRNA, miRNA and lncRNA. These findings show that high CARD11 expression in UVM is associated with poor OS high CARD11 expression in UVM is associated with poor OS Yes Functional enrichment analyses revealed that CARD11 was positively related to T cell activation pathways and cell adhesion molecules. The expressions of hub-genes were all increased in the high CARD11 expression group and the ceRNA network showed the interaction among mRNA, miRNA and lncRNA. 34370778 CAR10 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Regulation(Non-Small Cell Lung Cancer) RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay The present study demonstrated that CAR10 was upregulated in patients with NSCLC, which was also associated with a poor prognosis. Functionally, CAR10 was confirmed to be oncogenic and promoted NSCLC cell migration and invasion, using overexpression and knockdown Transwell assays. Furthermore, GJB2 expression was revealed to be upregulated and was positively correlated with CAR10 expression in NSCLC. A further mechanistic study revealed that GJB2 was a downstream target of CAR10, which induced the migration and invasive potential of the A549 and H1299 cell lines. More specifically, miR-892a was found to serve as a bridge between CAR10 and GJB2, via similar miRNA response elements. The RNA pull-down and luciferase assays indicated that miR-892a directly binds both CAR10 and GJB2. The present study demonstrated that CAR10 was upregulated in patients with NSCLC, which was also associated with a poor prognosis. Yes Functionally, CAR10 was confirmed to be oncogenic and promoted NSCLC cell migration and invasion, using overexpression and knockdown Transwell assays. 33664589 CAR10 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells regulation[CAR10/miR-125b-5p/PDPK1 network ] Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay We found that CAR10 is significantly increased in4 cervical cancer tissues and cells, which can promote the proliferation of cervical cancer cells in vitro and in vivo, indicating that CAR10 is involved in the progression of cervical cancer as an oncogene. In addition, our study also suggests that intervention of CAR10/miR-125b-5p/PDPK1 network may be a new strategy for targeted therapy of cervical cancer. Yes We found that CAR10 is significantly increased in4 cervical cancer tissues and cells, which can promote the proliferation of cervical cancer cells in vitro and in vivo, indicating that CAR10 is involved in the progression of cervical cancer as an oncogene. 32025520 CAR10 LncRNA Homo sapiens Melanoma melanoma tissues and cell lines regulation[miR-125b-5p/RAB3D axis] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay LncRNA CAR10 was upregulated in melanoma tissues and cell lines.Our work suggests that lncRNA CAR10 promotes melanoma growth and metastasis through modulating miR-125b-5p/RAB3D axis. Upregulation of CAR10 predicted a poor prognosis in patients with melanoma. Yes CAR10 knockdown suppressed proliferation, migration and invasion of melanoma cells in vitro. 32636644 CAMK2B LncRNA Homo sapiens Carcinoma, Renal Cell infiltrating stromal cells Interaction(GUSBP11/miR-432-5p/CAMK2B) qRT-PCR//Transfection//Immunoblotting//IHC We further evaluated the relationship between immune scores (ISs) and stromal scores (SSs) and disease progression and found that high SSs were associated with a poor prognosis in KIRP. Differentially expressed genes (DEGs) were therefore screened based on SS scores, resulting in 2509 DEGs, including 1668 mRNAs, 783 long noncoding (lnc)RNAs, and 58 micro (mi)RNAs. DEGs were then filtered using the random variance and subjected to hierarchical clustering using EPCLUST. Weighted gene co-expression network analysis (WGCNA) was used to assess the prognostic capacity of these DEGs and identify target ceRNA networks, and lncRNA GUSBP11/miR-432-5p/CAMK2B in the turquoise module was selected as a promising ceRNA network. From this analysis CAMK2B was selected as the core gene predicted to be involved in stromal TMA regulation. We therefore explored the expression and function of CAMK2B in vitro and in vivo and provide evidence that this protein promotes stromal TME remodulation and inhibits proliferation in KIRP. Lastly, we show that vascular endothelial growth factor (VEGF), transforming growth factor (TGF)β, and close homolog of L1 (CHL1) act as downstream effectors of CAMK2B in KIRP. Thus, in this study, we show that the TME determines prognosis of KIRP patients via the core effector molecule CAMK2B, which mediates both microenvironmental remodeling and tumor progression. Based on these findings, we propose that remodeling of the stromal microenvironment could represent an improved therapeutic approach relative to immunotherapy for KIRP. We further evaluated the relationship between immune scores (ISs) and stromal scores (SSs) and disease progression and found that high SSs were associated with a poor prognosis in KIRP. Yes We therefore explored the expression and function of CAMK2B in vitro and in vivo and provide evidence that this protein promotes stromal TME remodulation and inhibits proliferation in KIRP. 35127542 CALML3-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Interaction[ Wnt/β-catenin pathway] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay We found that CALML3-AS1 was upregulated in CC tissues and this upregulation was associated with FIGO stage, histological grade, and reduced overall survival.Mechanistic investigations revealed that inhibiting the expression of CALML3-AS1 decreased the levels of β-catenin, cyclin D1, and c-myc via Western blot. We found that CALML3-AS1 was upregulated in CC tissues and this upregulation was associated with FIGO stage, histological grade, and reduced overall survival. Yes Functional assays suggested that knockdown of CALML3-AS1 suppressed the proliferation, migration, and invasion of CC cells, and induced apoptosis. 31298313 CALML3-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(miR-20a-5p/RBM38 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The results indicated that the expression of both CALML3A-S1 and RBM38 were significantly downregulated in PTC tissues (p < 0.01), while the expression of miR-20a-5p was increased in PTC (p < 0.01). Mechanistically, CALML 3-AS1 sponged miR-20a-5p, which in turn leads to the suppression of RBM38 expression and PTC progression. Yes Functionally, CALML3-AS1 overexpression inhibited PTC cell proliferation in vitro and in vivo. 35351042 CAIF LncRNA Rattus norvegicus Myocardial Infarction cardiomyocytes Interaction(miR‑488/AVEN ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Flow Cytometry//RIP//FISH//Luciferase Report Assay//H&E Staining//IHC//EdU Staining CAIF was downregulated in the myocardium of I/R rats and cardiomyocytes treated with hydrogen peroxide (H2O2). Mechanistically, CAIF sponged microRNA (miR)‑488‑5p; this interaction was confirmed by rescue experiments. Moreover, miR‑488‑5p targeted apoptosis and caspase activation inhibitor (AVEN) and inhibited its expression. In summary, the present data identified a novel CAIF/miR‑488‑5p/AVEN signaling axis as a key regulator of myocyte apoptosis, which may be a potential therapeutic target for the treatment of MI. Yes Further experiments demonstrated that CAIF overexpression inhibited I/R‑induced cardiac infarction and apoptosis in vivo. CAIF decreased H2O2‑induced apoptosis and oxidative stress of cardiomyocytes. 35795990 CAHM LncRNA Homo sapiens Intervertebral Disc Degeneration BMSC-Exo, THP-1 and NPCs Expression(highly expressed) qRT-PCR//ELISA//Western Blot Compared with BMSCs, the expression of CAHM in BMSC-Exo was significantly higher. Using co-cultured experiments, we proved that BMSC-Exo reduced apoptosis and ECM degradation of NPCs by inhibiting M1-type macrophage polarization by delivering CAHM. In addition, BMSC-Exo could improve IDD in vivo, including increased proteoglycan content, reduced macrophage infiltration and ECM degradation, and decrease expression of inflammatory factors by delivering CAHM. Yes Using co-cultured experiments, we proved that BMSC-Exo reduced apoptosis and ECM degradation of NPCs by inhibiting M1-type macrophage polarization by delivering CAHM. In addition, BMSC-Exo could improve IDD in vivo, including increased proteoglycan content, reduced macrophage infiltration and ECM degradation, and decrease expression of inflammatory factors by delivering CAHM. 36334792 CADM1-AS1 LncRNA Homo sapiens Liver Neoplasms liver cancer tissue, cell lines Regulation[PTEN/AKT/GSK-3β axis] Western Blot//Wound Healing Assay//CCK8//Cell proliferation assay//PCR//Microarray//Colony Formation Assay//EdU Staining//Transwell Assay CADM1-AS1 expression was reduced in HCC. Meanwhile, we revealed that CADM1-AS1 inhibited the phosphorylation of AKT and GSK-3β. Furthermore, our study showed that CADM1-AS1 decreased the cell cycle associated proteins expression of cyclinD, cyclinE, CDK2 CDK4, CDK6, and enhanced the levels of p15, p21 and p27. More importantly, SC79, a specific activator for AKT;, apparently attenuated the effects of CADM1-AS1 on above cell-cycle associated proteins, confirming that CADM1-AS1 inhibited cell cycles through the AKT signaling pathway. And we also found the CADM1-AS1 has antitumor effect in vivo by a xenograft HCC mouse model. In conclusion, the present findings show that the CADM1-AS1 inhibits proliferation of HCC by inhibiting AKT/GSK-3β signaling pathway, then upregulate p15, p21, p27 expression and downregulate cyclin, CDK expression to inhibit the G0/G1 to S phase transition both in vitro and in vivo. Clinical data showed that this downregulation was associated with advanced tumor stage, high TNM stage and reduced survival in HCC patients. Yes CADM1-AS1 overexpression inhibited HCC cells proliferation, migration and invasion, while inducing G0/G1 phase arrest. 31118799 CACS15 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines Interaction[recruiting EZH2] RNA Pull-Down//ChIP//CCK8//qRT-PCR//RIP//Transwell Assay CACS15 was upregulated in OC tissues and cell lines relative to matched ones. LncRNA CACS15 inhibits the expression of APC by recruiting EZH2, thus accelerating the progression of ovarian cancer as an oncogene. Yes Knockdown of CACS15 attenuated proliferative, migratory and invasive abilities of OC cells. 31737207 CACNA1G-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[downregulating p53] qRT-PCR//Western Blot//RIP//ChIP CACNA1G-AS1 was upregulated in CRC tissues compared to adjacent normal ones. CACNA1G-AS1 downregulates p53 level by forming a carcinogenic complex with EZH2, thereby enhancing the proliferative and invasive abilities of CRC cells. Yes Knockdown of CACNA1G-AS1 reduced proliferative and invasive abilities of HTC116 and SW480 cells. 31957825 CACNA1G-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[miR-2392/C1orf61 pathway] RNA Pull-Down//ISH//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Invasion Assay Through bioinformatics analysis, we found that CACNA1G-AS1 expression was significantly upregulated in HCC tissues compared with that in the adjacent normal tissues. Collectively, CACNA1G-AS1 promotes HCC progression through regulating the miR-2392/C1orf61 pathway. Yes Knockdown of CACNA1G-AS1 attenuated the proliferation, migration, and invasion of HCC cells. In vivo assay also showed that CACNA1G-AS1 silencing HCC cells have smaller tumor volumes and weights. 30908634 CACNA1G-AS1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues and cells Interaction( miR-3160-5p) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis It was revealed that CACNA1G-AS1 was highly expressed in DLBCL tissues and cells and that expression of CACNA1G-AS1 was associated with the clinical stage of DLBCL. In addition, CACNA1G-AS1 could downregulate miR-3160-5p by targeting binding in DLBCL cells. Overexpression of miR-3160-5p had the same effects on the cytotoxicity and apoptosis of DLBCL cells as CACNA1G-AS1-knockdown. It was revealed that CACNA1G-AS1 was highly expressed in DLBCL tissues and cells and that expression of CACNA1G-AS1 was associated with the clinical stage of DLBCL. Yes Functionally, CACNA1G-AS1-knockdown was demonstrated to increase cytotoxicity and expedite apoptosis in DLBCL cells in vitro and in vivo. 36160896 CACNA1G-AS1 LncRNA Homo sapiens Keloid keloid tissues regulation[miR-205] CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay CACNA1G-AS1 level was up-regulated in keloid tissues and keloid fibroblasts.CACNA1G-AS1 suppressed miR-205 expression to promote proliferation and invasion and inhibit apoptosis in human keloid fibroblasts. Yes CACNA1G-AS1 overexpression promoted proliferation and invasion and suppressed apoptosis of keloid fibroblasts. 32495824 CASC19 LncRNA Homo sapiens Colorectal Neoplasms colon tissues,cell lines Regulation[CASC19/miR-140-5p/CEMIP axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Transwell Assay CASC19 expression was markedly upregulated in CRC tissues and CRC cell lines (P < 0.05).MiR-140-5p was found to be able to bind directly to CASC19 and CEMIP. Overexpression of miR-140-5p reversed the effect of CASC19 on cell proliferation and tumor migration, as well as suppressed CASC19-induced CEMIP expression. qRT-PCR revealed that CASC19 expression was higher in 25 tissue samples from patients with aggressive CRC compared with the 27 tissue samples from patients with nonaggressive CRC (P < 0.05). Higher CASC19 expression was associated with poorer patient prognoses. Yes Furthermore, in vitro experiments demonstrated that CASC19 overexpression enhanced CRC cell invasion, migration, and proliferation. CASC19 overexpression enhanced the expression of cell migration inducing hyaluronidase 1 (CEMIP) and epithelial-mesenchymal transition markers. 31011255 CASC19 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cells regulation[miR-301b-3p/LDLR axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay CASC19 is markedly overexpressed in NSCLC.CASC19 facilitates NSCLC cell proliferation and metastasis by targeting the miR-301b-3p/LDLR axis, offering a possible strategy for lncRNA-targeted treatment in NSCLC. Yes Finally, rescue experiments showed that miR-301b-3p inhibition or LDLR overexpression counteracted the CASC19 knockdown-mediated function on cell proliferation and metastasis in NSCLC. 32677267 CASC19 LncRNA Homo sapiens Stomach Neoplasms cell lines (AGS, BGC-823, MGC-803, and HGC-27) Expression[highly expressed] CCK8//qRT-PCR//Transwell Assay Furthermore, quantitative real-time PCR assay confirmed that CASC19 expression in four human gastric cancer cells (AGS, BGC-823, MGC-803, and HGC-27) was significantly upregulated compared with human normal gastric mucosal epithelial cell line (GES-1). Cancer susceptibility 19 (CASC19) was the top hub lncRNA among the lncRNAs included in the gene module most significantly correlated with AGC's pathological variables. CASC19 was upregulated in AGC clinical samples and was significantly associated with higher pathologic TNM stage, pathologic T stage, lymph node metastasis, and poor overall survival.Multivariable Cox analysis confirmed that CASC19 overexpression is an independent prognostic factor for overall survival. Yes Functionally, CASC19 knockdown inhibited GC cell proliferation and migration in vitro. 31422382 CASC9 LncRNA Homo sapiens Colonic Neoplasms CC cells and tissues Interaction[sponging miR-145-5p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay LncRNA CASC9 was high-expressed in CC cells and tissues, especially in CC at advanced TNM stages.LncRNA CASC9 is an oncogene in CC cells through sponging miR-145-5p. The findings in the current study provide a new understanding on CASC9 in CC. Yes In HCT116 and SW480 cells, knockdown of CASC9 suppressed cell proliferation, promoted cell apoptosis and arrested cell cycle at G0/G1 phase. 35117034 CASC9 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues/ cells regulation[down-regulating miR-424-5p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Higher expression of CASC9 was observed in HCC tissues/ cells than in adjacent normal tissues/ human hepatic epithelial cells, and was closely linked to poor prognosis of HCC, tumor size, TNM stage, differentiation degree, lymph node metastasis and alpha-fetoprotein (AFP). CASC9 promoted proliferation, invasion and migration and inhibited apoptosis in HCC cells by inhibiting miR-424-5p. Higher expression of CASC9 was observed in HCC tissues/ cells than in adjacent normal tissues/ human hepatic epithelial cells, and was closely linked to poor prognosis of HCC, tumor size, TNM stage, differentiation degree, lymph node metastasis and alpha-fetoprotein (AFP). Yes Down-regulation of CASC9 decreased the proliferation, invasion and migration of HCC cells while enhancing apoptosis. 33346094 CASC9 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues,cell lines interaction[FZD6/Wnt/β-catenin signaling pathway] CCK8//qRT-PCR//FISH This study found that CASC9 expression was markedly upregulated in bladder cancer and related to histological grade, TNM stage and prognosis. In summary, lncRNA CASC9 plays a critical regulatory role in bladder cancer. The CASC9/miR-497-5p/ FZD6 axis provides insights for regulatory mechanism of bladder cancer, and new strategies for clinical practice. This study found that CASC9 expression was markedly upregulated in bladder cancer and related to histological grade, TNM stage and prognosis. Yes Knockdown of CASC9 inhibited tumor growth and metastasis of bladder cancer in vitro and in vivo. 32677984 CASC9 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder tissues,cell lines interaction[sponges miR-758-3p] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//FISH//EdU Staining//Transwell Assay CASC9 expression was significantly upregulated in BC cell lines and specimens compared to that in adjacent normal bladder tissues.Collectively, these results indicated that CASC9 sponged miR‑758‑3p to regulate the expression of TGF‑β2, which activated the TGF‑β signaling pathway and promoted proliferation and EMT in BC. Upregulated CASC9 was associated with increased invasion ability and poor prognosis of BC. Yes CASC9 knockdown inhibited BC cell proliferation, migration and invasion. 33200222 CASC9 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines interaction[EZH2 ] Wound Healing Assay//CCK8//qRT-PCR//RIP//Colony Formation Assay//Transwell Assay CASC9 was upregulated in BC tissues and cell lines, and correlated with the staging and metastasis in BC. Upregulation of CASC9 induced by STAT3 promoted the progression of BC by interacting with EZH2 and affecting the expression of PTEN, representing a novel regulatory mechanism for BC progression. CASC9 was upregulated in BC tissues and cell lines, and correlated with the staging and metastasis in BC. Yes Knockdown of CASC9 inhibited the proliferation, migration, and invasion of BC cells. Similarly, silencing of CASC9 inhibited tumor growth in vivo. 32982303 CASC9 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Regulation[AKT/mTOR pathway] Western Blot//ISH//Tunel//Flow Cytometry//qRT-PCR//MTT//IHC In this study, we found for the first time that CASC9 was remarkably upregulated in OSCC tissues and cell lines compared with paired noncancerous tissues and normal oral epithelial cells. In conclusion, our findings demonstrate that lncRNA CASC9 promotes OSCC progression through enhancing cell proliferation and suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway. Highly expressed CASC9 is strongly associated with tumor size, clinical stage, regional lymph node metastasis and overall survival time in OSCC patients. Yes In vitro, CASC9 knockdown in OSCC cells SCC15 and CAL27 significantly promotes autophagy and apoptosis, while inhibiting proliferation. 30674868 CASC9 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Interaction(microRNA-545-3p/LAMC2) Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Colony Formation Assay//Bioinformatics Analysis Our study confirmed that lncRNA CASC9 and LAMC2 were upregulated in OSCC, whereas miR-545-3p expression was reduced. In addition, we proved for the first time that lncRNA CASC9 can sponge miR-545-3p to upregulate LAMC2. Yes After performing a series of cell functional experiments, it was found that knockdown of lncRNA CASC9 or LAMC2 resulted in the inhibition of proliferation, colony formation, and migration of OSCC cells, but their negative effects could be partly impaired by the miR-545-3p inhibitor. 34612783 CASC9 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction( miR-874-3p/SOX12 axis) In Vivo Experiment//IHC//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LncRNA CASC9 was found to be up-regulated in OS.Besides, miR-874-3p was identified as the target of CASC9, and SOX12 acted as a potential target of miR-874-3p. The down-regulation of miR-874-3p recovered the reduction in cell invasion and proliferation in vitro which were induced by CASC9 knockdown and delayed the tumor progression in vivo. Yes Knockdown of CASC9 inhibited the proliferation and invasion of OS cells. 36266695 CASC9 LncRNA Homo sapiens Glioma glioma specimens and cells Regulation[CASC9/miR-519d/STAT3] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Results manifested that CASC9 was highly expressed in glioma specimens and cells, moreover, the ectopic overexpression was correlated with glioma patients' clinic. In conclusion, our results concluded that CASC9 promotes STAT3 expression via sponging miR-519d, in return, STAT3 activate CASC9 transcription, forming a positive feedback loop of CASC9/miR-519d/STAT3. Results manifested that CASC9 was highly expressed in glioma specimens and cells, moreover, the ectopic overexpression was correlated with glioma patients' clinic. Yes Functional studies found that siRNA-mediated CASC9 silencing inhibited the proliferative ability, invasion in vitro, and impaired the tumour growth in vivo. 30270508 CASC9 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction[regulating miR-145] Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The expression level of CASC9 was upregulated in NPC tissues and cells. CASC9 knockdown inhibited cell migration and invasion but increased cell apoptosis in NPC cells by regulating miR-145, providing a novel insight for the treatment of NPC. Yes knockdown of CASC9 evidently suppressed migration and invasion but promoted apoptosis in NPC cells. 31933798 CASC9 LncRNA Homo sapiens Nasopharyngeal carcinoma nasopharyngeal carcinoma cells Interaction(miR-497-5p/Wnt3a/β-catenin Signaling Pathway) In Vivo Experiment//Western Blot//Invasion Assay//Migration Assay//Flow Cytometry//qRT-PCR//FISH//MTT//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis Mechanism research confirmed CASC9 regulated the malignant biological behavior of nasopharyngeal carcinoma cells by targeting miR-497-5p/Wnt3a/β-catenin signaling pathway. In this study, we found that CASC9 was overexpressed and associated with worse prognosis in NPC. Yes CASC9 knockdown significantly inhibited the cell proliferation, migration and invasion in vitro and enhanced the sensitivity of tumor cells to cisplatin and paclitaxel. 35419295 CASC9 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells regulation[miR-488-3p/ADAM9 pathway] Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We found that CASC9 expression was augmented in human PTC tissues and cells.In conclusion, lncRNA CASC9 promoted the malignant phenotypes of PTC via modulating miR-488-3p/ADAM9 pathway. Higher CASC9 expression was associated with large tumor size, advanced stage, or lymph node metastasis. Yes Downregulation of CASC9 significantly attenuated the proliferative, migrative, and invasive abilities of PTC cells, and suppressed tumorigenesis in vivo. 31943867 CASC9 LncRNA Homo sapiens Retinoblastoma RB tissues and cells interaction[interacting with miR-145-5p] qRT-PCR//Luciferase Report Assay//RIP We found that CASC9 expression was elevated in RB tissues and cells.These findings suggested that CASC9 contributed to RB development by regulating E2F3 via sponging miR-145-5p. Yes Overexpression of CASC9 significantly facilitated the proliferation, invasion and EMT of RB cells. On the contrary, knockdown of CASC9 inhibited the proliferation, invasion and EMT, while enhanced the apoptosis of RB cells. 32772636 CASC9 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and cells regulation[ miR-423-5p/SOX12 Axes] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay CASC9 was up-regulated in the TSCC tissues and cells, and predicted a poor prognosis. miR-423-5p was predicted as the targeting miRNA of CASC9; this was verified by a luciferase reporter assay. CASC9 expression showed a negative correlation with miR-423-5p expression and a positive correlation with SOX12 expression. CASC9 was up-regulated in the TSCC tissues and cells, and predicted a poor prognosis. Yes CASC9 silencing significantly inhibited cell proliferation, migration, and invasion of the TSCC cells compared with the non-targeting control small interfering RNA (siCtrl) treatment. 32021442 CASC9 LncRNA Homo sapiens laryngeal carcinoma laryngeal carcinoma tissues,cell lines Interaction[GLUT-1] qRT-PCR//MTT//Transwell Assay Using quantitative reverse transcriptase PCR, we found higher expression of CASC9 and GLUT-1 in laryngeal carcinoma tissues and cells, compared to adjacent tissues and cells. The results showed that transfection with an overexpressed GLUT-1vector reversed the effects of silencing CASC9 on proliferation, migration, and apoptosis in TU212 and Hep-2 cells. Yes An MTT assay of TU212 and Hep-2 cells showed increased cell proliferation after transfection with overexpressed CASC9 and decreased cell proliferation after transfection with silenced CASC9.A Transwell assay showed that overexpressing CASC9 increased and silencing CASC9 decreased cell migration of TU212 and Hep-2 cells. A flow cytometry assay showed that overexpressing CASC9 reduced and silencing CASC9 increased cell apoptosis. In other words, we found that overexpressing CASC9 increased cell proliferation and cell migration and decreased apoptosis both in TU212 and Hep-2 cells, whereas silencing CASC9 had the opposite effects. 31669650 CASC9 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Expression[highly expressed] CCK8//qRT-PCR Finally, the potential function of two lncRNAs (CASC9 and LINC00152) that were upregulated in OC tissues and associated with patients' survival time was verified by loss-of-function assays in OC cells. Moreover, lots of lncRNAs expression levels are associated with OC patients' overall survival and recurrence-free survival; for example, higher CASC9, LINC01232, and MIR4435-1HG expression levels are related to shorter overall survival and recurrence-free survival in OC patients. Yes Next, CCK8 assays showed that knockdown of CASC9 and LINC00152 inhibited SCC4 and SCC25 cells’ proliferation compared with control cells (Fig. 4c–f). 30543527 CASC9 LncRNA Homo sapiens Ovarian Neoplasms OC cells Interaction(miR-488-3p/cyclinG1/TP53/MMP7 signaling) Bioinformatics Analysis The results of our study revealed that CASC9 expression was upregulated while miR-488-3p and CCNG1 expression was downregulated in OC cells with significant higher TP53 and MMP7 protein levels compared with normal ovarian surface epithelial cells. Additionally, luciferase reporter assay confirmed CASC9 bond to miR-488-3p/CCNG1. Yes CASC9 silencing inhibited cell proliferation, migration, and invasion whereas promoted cell inhibition rate and apoptosis in vitro and in vivo . However, CASC9 overexpression showed the opposite effects. 34595994 CASC9 LncRNA Homo sapiens Pneumonia serum samples Expression(lower expressed) Transfection//CCK8//qRT-PCR//Cell Apoptosis Assay//ELISA The relative expression of CASC9 was downregulated in serum samples of severe pneumonia patients. The low expression of CASC9 in severe pneumonia was negatively correlated with several clinical data. The CASC9 had the relatively high area under ROC curve (AUC) values for distinguishing severe pneumonia from pneumonia children and healthy control. Yes The elevated expression of CASC9 accelerated cell viability and diminished apoptosis in LPS-induced MRC-5 cells. The CASC9 expression was decreased in serum samples of severe pneumonia, and upregulation of CASC9 facilitated LPS-induced cell viability and inhibited apoptosis. 35587261 CASC9 LncRNA Homo sapiens Colonic Neoplasms serum Expression(highly expressed) qRT-PCR Patients with CC showed notably higher lncRNA CASC9 expression than controls ncRNA CASC9 presented an association with the clinical stage of the patients. In addition, lncRNA CASC9 demonstrated a clinical value in predicting efficacy on patients and acted as one independent prognostic factor for PFS in patients with ACC. Yes lncRNA CASC9 demonstrated a clinical value in predicting efficacy on patients and acted as one independent prognostic factor for PFS in patients with ACC. 34589129 CASC9 LncRNA Homo sapiens Colorectal Neoplasms CRC specimens and cell lines Interaction(MiR-542-3p/ILK) CCK8//qRT-PCR//Western Blot//Transwell Assay We demonstrated long non-coding RNA cancer susceptibility candidate 9 in CRC specimens and cell lines overexpressed via real-time quantitative polymerase chain reaction. This study testified that silencing long non-coding RNA cancer susceptibility candidate 9 could inhibit proliferation and invasion of CRC cells by miR-542-3p/integrin-linked kinase. Yes Once long non-coding RNA cancer susceptibility candidate 9 was knocked down, it significantly inhibited proliferation, invasion, and migration of CRC cells in real-time quantitative polymerase chain reaction, cell counting kit-8, 5-ethynyl-2'-deoxyuridine, and transwell assays, which also was validated in vivo. 35427373 CASC2 LncRNA Mus musculus Hypertension, Pulmonary pulmonary artery smooth muscle cells Expression[lower expressed] qRT-PCR//Wound Healing Assay//EdU Staining//Western Blot The expression of lncRNA CASC2 was decreased in hypoxia-induced rat pulmonary arterial tissues and pulmonary artery smooth muscle cells (PASMCs). Western blot analysis and immunochemistry showed that up-regulation of lncRNA CASC2 greatly decreased the expression of phenotype switch-related marker α-SMA in hypoxia-induced PH. Furthermore, it was indicated by the pulmonary artery morphometric analysis that lncRNA CASC2 suppressed vascular remodeling of hypoxia-induced rat pulmonary arterial tissues. Yes Up-regulation of lncRNA CASC2 inhibited cell proliferation, migration yet enhanced apoptosis in vitro and in vivo in hypoxia-induced PH. 30857524 CASC9 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[CASC9/miR-576-5p/AKT3 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining In this study, we found that CASC9 was significantly upregulated in CRC tissues and cell lines compared to normal controls and that aberrant expression was associated with the tumor-node-metastasis (TNM) stage of CRC.In summary, we identified CASC9 as an oncogenic lncRNA in CRC and defined the CASC9/miR-576-5p/AKT3 axis, which might be considered a potential therapeutic target for CRC patients, as a novel molecular mechanism implicated in the proliferation and apoptosis of CRC. In this study, we found that CASC9 was significantly upregulated in CRC tissues and cell lines compared to normal controls and that aberrant expression was associated with the tumor-node-metastasis (TNM) stage of CRC. Yes Functionally, CASC9 depletion efficiently inhibited the proliferation of CRC cells and induced cell apoptosis in vitro. 33298846 CBR3-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Interaction(miR-3163/LASP1 pathway) Other Besides, we identified that lncRNA CBR3-AS1 interacted with miR-3163, and miR-3163 targeted to LASP1. Moreover, the correlation between lncRNA CBR3-AS1 and miR-3163, as well as the correlation between miR-3163 and LASP1 was confirmed. Yes LncRNA CBR3-AS1 knockdown suppressed cervical cancer cell viability and inhibited cancer stem cell-like properties. Finally, lncRNA CBR3-AS1 knockdown inhibited tumor growth and suppressed cancer stem cell-like properties of cervical cancer in vivo. 36591804 CBR3-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LAD and cell lines Regulation(Wnt/β-catenin signaling) RNA Pull-Down//Western Blot//qRT-PCR//RIP//Colony Formation Assay LncRNA CBR3-AS1 is highly-expressed in LAD and cell lines. LncRNA CBR3-AS1 shows physical association with β-catenin. CBR3-AS1 could facilitate Wnt/β-catenin signaling activation thought promoting nuclear localization of β-catenin. Yes CBR3-AS1 promotes LAD cell proliferation, migration and invasion by targeting Wnt/β-catenin signaling. 33422081 CBR3-AS1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues Regulation(PTEN/Akt axis) In Vivo Experiment//Western Blot//qRT-PCR//FISH//Cell Cycle Assay//IHC We found that PlncRNA-1 was up-regulated in 85.29% of PCa tissues and could predict the T stage of PCa patients to a certain extent. PlncRNA-1 can promote the occurrence and development of PCa via the PTEN/Akt pathway. Yes Results showed that inhibition of PlncRNA-1 expression potentially promoted cell apoptosis, suppressed the proliferation, migration, and invasion of cells, and triggered G2/M cycle arrest in vitro and in vivo. 33848262 CBR3-AS1 CircRNA Homo sapiens gestational choriocarcinoma GC cells Interaction(PTBP1/SETD4 ) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay CBR3-AS1 was markedly upregulated in GC cells, and its downregulation suppressed cell proliferation, induced cell cycle arrest, but promoted cell apoptosis in GC. . SETD4 was determined as the downstream mRNA of CBR3-AS1 and positively regulated by CBR3-AS1 in GC cells. Furthermore, CBR3-AS1 could interact with its RNA binding protein (RBP) PTBP1, thereby stabilizing SETD4 mRNA. Rescue assays verified that CBR3-AS1 facilitates GC cell malignant proliferation via SETD4. Yes CBR3-AS1 was markedly upregulated in GC cells, and its downregulation suppressed cell proliferation, induced cell cycle arrest, but promoted cell apoptosis in GC. 35655916 CATIP-AS1 LncRNA Homo sapiens Thyroid Neoplasms THCA tissues and cells Interaction(miR-515-5p/Smad4 ) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay The result shows that the CATIP-AS1 was significantly downregulated in THCA tissues and cells and was associated with a poor prognosis of patients diagnosed with THCA.Summarily, we demonstrated that the CATIP-AS1 promotes the progression and metastasis of THCA via EMT pathway partly through regulating the miR-515-5p and Smad4 expression in THCA cell. The result shows that the CATIP-AS1 was significantly downregulated in THCA tissues and cells and was associated with a poor prognosis of patients diagnosed with THCA. Yes The overexpression of CATIP-AS1 significantly inhibited THCA cell proliferation, migration, and epithelial-mesenchymal transition (EMT) but increased the THCA cell apoptosis. We found that CATIP-AS1 endogenously sponges miR-515-5p and its overexpression could inhibit miR-515-5p regulatory effect. 35264071 CASP5 LncRNA Homo sapiens Glioblastoma GBM tissues and cell lines Expression [highly expressed] CCK8//Transwell Assay//Flow Cytometry//Western Blot We observed that lncRNA CASP5 was highly expressed in GBM tissues and cell lines.We demonstrate for the first time the potential oncogenic role of lncRNA CASP5 which may be helpful for identifying novel therapeutic targets in GBM. Yes Knockdown of CASP5 greatly inhibited GBM proliferation and resulted in G1 cell cycle arrest along with higher apoptosis ratios in vitro and in vivo, while overexpression led to the opposite phenomenon. Furthermore, the migration and invasion ability of GBM cells were significantly decreased after CASP5 down-regulation, while increased migration and invasion can be observed after CASP5 up-regulation. 29715460 CASC9-1 LncRNA Homo sapiens cervical squamous cell carcinoma cervical SCC cells Interaction( miR-383-5p/MAPKAP1) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tunel//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay CASC9-1 was up-regulated in cervical SCC cells. In terms of mechanism, CASC9-1 directly targeted miR-383-5p, and MAPKAP1 was the target gene of miR-383-5p in cervical SCC cells. CASC9-1 could exacerbate malignant behaviors of cervical SCC cells via binding to miR-383-5p and regulating MAPKAP1. Yes CASC9-1 knockdown repressed cervical SCC cell proliferation, migration and invasion while elevating apoptosis. Via in-vivo experiments, CASC9-1 down-regulation was proved to restrict cervical SCC tumor growth. 34857398 CASC9 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[Regulating BMI1] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP LncRNA CASC9 was upregulated in GC tissue and GC cells.LncRNA CASC9 could interact with BMI1 and positively regulate BMI1 expression. Silencing CASC9 promoted the ubiquitination of BMI1. In addition, lncRNA CASC9 regulated the apoptosis of GC cells through BMI1. Furthermore, interfering CASC9 inhibited the tumor growth of GC. LncRNA CASC9 could interact with BMI1 to regulate the degradation of BMI1, thus to affect the apoptosis of GC cells and suppressed tumor growth. LncRNA CASC9 was upregulated in GC tissue and GC cells, and high CASC9 expression was positively correlated with TNM stage and lymph node metastasis. Yes Silencing CASC9 promoted the apoptosis of GC cells. 31642035 CASC9 CircRNA Homo sapiens Stomach Neoplasms Eighty GC tissues and paired adjacent normal tissues Interaction(miR-370/EGFR axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Bioinformatics Analysis//CCK8//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Cell Apoptosis Assay//Cell Cycle Assay//Colony Formation Assay//Invasion Assay Our results showed that CASC9 was up-regulated significantly in both GC tissues and cell lines. Further analysis indicated that CASC9 directly targeted miR-370 and negatively regulated miR-370 expression in GC. Besides, EGFR (epidermal growth factor receptor) was identified as a direct target gene of miR-370. Yes Conversely, CASC9 knockdown inhibited GC growth in vitro. 33478874 CASC9 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction[sponging miR‑195/497] Western Blot//ISH//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay In the present study, lncRNA CASC9 was found to be significantly upregulated in both BC tissues and cell lines. Moreover, mechanical experiments demonstrated that lncRNA CASC9 positively regulated checkpoint kinase 1 (CHK1) by competitively binding to the miR‑195/497 cluster in BC cells. Additionally, the knockdown of lncRNA CASC9 was observed to suppress breast tumor growth in vivo. Taken together, the results of this study indicate that lncRNA CASC9 plays an oncogenic role in BC through sponging the miR‑195/497 cluster, and that lncRNA CASC9 may be used as a novel therapeutic target and as a potential diagnostic marker for BC. Yes Furthermore, functional analyses revealed that lncRNA CASC9 accelerated BC cell proliferation, promoted cell cycle progression and suppressed cell apoptosis. 30816435 CASC9 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction(miR-590-3p) CCK8//qRT-PCR//Flow Cytometry//Transwell Assay CASC9 protein was overexpressed in BC cells and tissues, while CASC9 knockdown inhibited BC cell growth, invasion, and migration and promoted apoptosis. Yes CASC9 protein was overexpressed in BC cells and tissues, while CASC9 knockdown inhibited BC cell growth, invasion, and migration and promoted apoptosis. 34711117 CASC9 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction(STAT3-activated CASC9 ) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay//ChIP CASC9 was found to be highly expressed in BC tissues and cell lines, and ectopic overexpression was positively associated with tumor volume, TNM stage, and lymph node metastasis.Mechanical studies demonstrated that CASC9 could be transcriptionally activated by STAT3 and elevate SOX4 expression by enhancing the acetylation of its promoter region. Our results illustrated that STAT3-activated CASC9 served as a tumor-promoting gene involved in promoting BC invasion and BC-associated formation of lymphatic vessels by upregulating SOX4 through altering H3K27ac level. CASC9 was found to be highly expressed in BC tissues and cell lines, and ectopic overexpression was positively associated with tumor volume, TNM stage, and lymph node metastasis. Yes In addition, CASC9 silencing significantly inhibited the proliferation and invasion of BC cells, as well as BC-associated invasion and formation of lymphatic vessels of human dermal lymphatic endothelial cells. 35860965 CASC9 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues interaction[Binding to HuR] CCK8//qRT-PCR//RIP//Flow Cytometry//Transwell Assay CASC9, CDC6 and HuR expression were found significantly upregulated in NSCLC tissues, which predicted poorer 5-year overall survival in NSCLC patients. CASC9, CDC6 and HuR expression were found significantly upregulated in NSCLC tissues, which predicted poorer 5-year overall survival in NSCLC patients. Yes Inhibition of CASC9 significantly reduced the malignancy of NSCLC cells, such as proliferation, migration and cell cycle. In vivo experiments further demonstrated that CASC9 knockdown reduced the tumor growth and the Ki-67 expression. 33061598 CASC9 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[miR-335-3p/S100A14 axis] qRT-PCR In this study, we found CASC9 expression was upregulated in NSCLC tissues and cell lines. Taken together, our study suggested CASC9 could promote NSCLC progression via miR-335-3p/S100A14 axis. High CASC9 expression was identified as a predictor for poorer overall survival of NSCLC patients. Yes Furthermore, functional assays showed CASC9 knockdown suppressed NSCLC cell proliferation, migration, and invasion, while CASC9 overexpression caused opposite effects. 32606808 CASC9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues regulation[APOBEC3G] Western Blot//Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay The expression of lncRNA ESCCAL-1 is upregulated in esophageal squamous cell carcinoma (ESCC). This study demonstrates that the lncRNA ESCCAL-1 promotes malignant features of ESCC by relieving the inhibitory effect of miR-590-3p on APOBEC3G expression and identifies potential biomarkers or therapeutic targets to improve ESCC treatment outcomes. Yes Furthermore, depletion of ESCCAL-1 in ESCC models inhibited the cellular processes associated with malignancy, including proliferation, migration and invasion, resistance to apoptosis, and impaired tumor growth in mice. 32905814 CASC9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(ESCCAL-1/miR-590/LRP6 signaling pathway ) CCK8//qRT-PCR//Western Blot The present work discovered the ESCCAL-1 up-regulation within ESCC. . Furthermore, ESCCAL-1 was found to interact with miR-590 and consequently restrict its expression. Importantly, it was confirmed that LRP6 was miR-590's downstream target and LRP6 over-expression also partly abolished the role of miR-590 overexpression in ESCC cells. Yes Functionally, knocking down ESCCAL-1 or over-expressing miR-590 hindered ESCC cell growth, invasion, and migration in vitro. Moreover, inhibition of miR-590 could reverse the effect of knockdown of ESCCAL-1 on cells. 35655441 CASC9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(Gal-1/NF-κB signaling) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//Cell Proliferation Assay//IP//Transwell Assay Multiple LncRNA expression datasets as well as our own data together reveal that ESCCAL-1 is evidently up-regulated in ESCC tissues and exhibits promising diagnostic value. Mechanistically, LncRNA ESCCAL-1 directly binds to Gal-1 and positively regulates its protein level without affecting its mRNA level. Up-regulation of Gal-1 facilitated ESCC cell proliferation and cell-cycle progress. Knockdown of Gal-1 mitigated the effects of ESCCAL-1-mediated high cellular proliferation, NF-κB signaling activation and tumorigenicity of ESCC cells. Yes Over-expression of ESCCAL-1 augmented ESCC cell proliferation and cell-cycle progression, whereas down-regulation of ESCCAL-1 resulted in the opposite effects. 35233069 CASC9 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell lines Interaction[CASC9/HIF-1α axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Colony Formation Assay//Transwell Assay CASC9 was overexpressed in lung cancer specimens and cell lines. Our findings demonstrated a novel regulatory signaling pathway, namely the CASC9/HIF-1α axis, which was involved in lung cancer progression. Yes Knockdown of CASC9 inhibited cell proliferation, migration, invasion and EMT in lung cancer cells. While overexpression of CASC9 in normal lung epithelial cells did the opposite. 31802910 CASC9 LncRNA Homo sapiens Colorectal Neoplasms Regulation[CASC9-CPSF3-TGFβ2 axis] qRT-PCR//RNA Pull-Down//RIP//Western Blot CASC9 was frequently upregulated in CRC, which was correlated with advanced TNM stage, and higher CASC9 levels were associated with poor patient outcomes.CASC9 is a promising prognostic predictor for patients with CRC and the CASC9-CPSF3-TGFβ2 axis is a potential therapeutic target for CRC treatment. CASC9 was frequently upregulated in CRC, which was correlated with advanced TNM stage, and higher CASC9 levels were associated with poor patient outcomes. Yes Knockdown of CASC9 inhibited growth and promoted apoptosis in CRC cells, whereas ectopic CASC9 expression promoted cell growth in vitro and in vivo. 31186036 CASC9 LncRNA Rattus norvegicus Spinal Cord Injuries SCI rats and LPS-induced PC12 cells. Interaction(miR-383-5p/ Furthermore, miR-383-5p was a direct target of CASC9 and was negatively regulated by CASC9. LDHA was a direct target of miR-383-5p and was negatively regulated by CASC9. ) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//ELISA The results showed that lncRNA CASC9 was downregulated and miR-383-5p was upregulated in SCI rats and LPS-induced PC12 cells. Furthermore, miR-383-5p was a direct target of CASC9 and was negatively regulated by CASC9. LDHA was a direct target of miR-383-5p and was negatively regulated by CASC9. Yes Severe histological injury and increased water content were also found in SCI rats. Increased levels of LDH, MDA, lactic acid, TNF-α, and IL-1β were found in SCI rats and LPS-induced PC12 cells. These changes could be reversed by MP treatment in vivo or overexpression of CASC9 in vitro.Besides, overexpression of CASC9 decreased cell apoptosis and protein expression of LDHA and increased protein expression of Nrf2 and HO-1 in LPS-induced PC12 cells. 33438067 CASC8 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction(hnRNPL/Bcl2/caspase3 pathway) ISH//qRT-PCR//RNA Pull-Down//RIP CASC8 was highly overexpressed in ESCC tissues and upregulation of CASC8 predicted poor prognosis in ESCC patients. Mechanistically, CASC8 interacted with heterogeneous nuclear ribonucleoprotein L (hnRNPL) and inhibited its polyubiquitination and proteasomal degradation, thus stabilizing hnRNPL protein levels and activating the Bcl2/caspase3 pathway. Additionally, AlkB Homolog 5, RNA demethylase (ALKBH5)-mediated m6A demethylation stabilized the CASC8 transcript, resulting in CASC8 upregulation. CASC8 was highly overexpressed in ESCC tissues and upregulation of CASC8 predicted poor prognosis in ESCC patients. Yes Moreover, CASC8 decreased the cisplatin sensitivity of ESCC cells and promoted ESCC tumor growth in vivo. 35982900 CASC2c LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and corresponding non-cancer tissues,cell lines(H292、H226、H1975、H460) Regulation[ERK1/2 and β-catenin signaling pathways ] qRT-PCR//MTT//Transwell Assay//Western Blot The results showed that CASC2c expression was significantly down-regulated in NSCLC tissues compared to matched adjacent non-tumor tissues (2.765 ± 1.605 v.s. 1.137 ± 0.754, p < 0.05, Fig. 1a). Furthermore, the expression of CASC2c in NSCLC cell lines (including H292, H226, H1975 and H460) were significantly lower than that in BEAS-2B cells (p < 0.05).Western blot assay showed that the high-expressed CASC2c can decrease the expression of phosphorylated-ERK1/2 (p-ERK1/2) and β-catenin. In addition, the CASC2c expression was remarkably correlated with TNM staging, tumor cell differentiation, lymph node metastasis, smoking and other pathological indicators of patients with NSCLC (p < 0.05). Yes What's more, it inhibited the proliferation and migration of NSCLC cells by inhibiting the expression of p-ERK1/2 and β-catenin and reversed NSCLC cells' resistance to the chemotherapy drug cisplatin. 31300295 CASC2c LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Regulation[ERK1/2 and Wnt/β-catenin signaling pathway] qRT-PCR In the present work, we observed that CASC2c was significantly down-regulated in HCC tissues and cells.Furthermore, we demonstrated that CASC2c overexpression decreased p-ERK1/2 levels in HCC, GC, and CRC cells. Interestingly, while overexpression of CASC2c decreased β-catenin expression in HCC and GC cells, it increased that in CRC cells. Yes Moreover, its overexpression remarkably inhibited the growth, migration, and invasion of HCC cells in vitro and promoted their apoptosis. 31625123 CASC2 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines Regulation[PTEN/Akt signaling] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//BrdU//ChIP According to recent studies, long noncoding RNA-CASC2 is involved in the development and progression of many malignant tumors; in the present study, we demonstrated that lncRNA-CASC2 was specifically downregulated in PC tissues and cell lines, and a lower CASC2 expression in PC was related with a poorer prognosis.CASC2 suppressed PC cell proliferation. Yes CASC2 suppressed PC cell proliferation. 28865121 CASC2 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues,cell lines regulation[miR‑24/MUC6 axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay CASC2 and MUC6 were downregulated, and miR?24 was upregulated in pancreatic cancer specimens and cell lines. CASC2 exerted tumor‑suppressive functions in pancreatic cancer through the miR‑24/MUC6 axis, which may be a promising target for pancreatic cancer therapy. Yes Functionally, CASC2 overexpression or miR?24 knockdown suppressed pancreatic cancer cell proliferation, colony formation, migration and invasion, and promoted apoptosis. 31894271 CASC2 LncRNA Homo sapiens Adenocarcinoma of Lung adenocarcinoma tissues,cell lines Interaction[miR-4735-3p and mTOR] qRT-PCR We found that long noncoding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2), a putative tumor suppressor, was downregulated in both patient adenocarcinoma tissues and cultured lung cancer cells. Furthermore, the lncRNA and miR-4735-3p interplay likely the suppressed tumor growth through the downstream mammalian target of rapamycin signaling pathway. The results have revealed molecular details that may be critical for the development of lung adenocarcinoma, opening opportunities for the development of novel, and therapeutic tools. Yes Changing the levels of CASC2 and miR-4735-3p in the cultured adenocarcinoma cells could affect the malignant phenotypes as well as growth of tumors derived from the cells injected into nude mice. 30450692 CASC2 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD patients and LUAD cell lines Interaction(miR-21/p53 axis) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay CASC2 was expressed at a low level in LUAD patients and LUAD cell lines. Mechanistically, CASC2 overexpression dramatically inhibited miR-21 expression and increased p53 expression by directly targeting miR-21. Yes CASC2 overexpression markedly suppressed cell proliferation and enhanced apoptosis. 34337857 CASC2 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cells regulation[miR-18a/SOCS5 axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot It was found that CASC2 was expressed at a significantly lower level in CCA tissues and cell lines. CASC2 was downregulated in CCA tissues and cells. It could inhibit cell proliferation, invasion, migration and EMT via sponging miR-18a/SOCS5 axis. Yes The overexpression of CASC2 inhibited QBC939 cell proliferation, invasion and migration when the knockdown of CASC2 accelerated HUCCT1 cell growth and metastasis. 32894543 CASC2 LncRNA Homo sapiens Prostatic Neoplasms PC tissues and cell lines Expression[lower expressed] qRT-PCR Herein, CASC2 and SPRY2 expression was down-regulated in PC tissues and cell lines Yes the overexpression of CASC2 and SPRY2 could suppress PC cell proliferation, promote PC cell apoptosis 29373811 CASC2 LncRNA Homo sapiens Melanoma MM tissues Interaction[miR-18a-5p/RUNX1] MTT//Luciferase Report Assay//Transwell Assay The levels of CASC2 and RUNX1 were significantly reduced in MM tissues compared with normal skin tissues or cells, while the miR-18a-5p level was obviously increased (all p < 0.01). The luciferase reporter assay revealed that CASC2 acted as a molecular sponge for miR-18a-5p, and RUNX1 was a target gene of miR-18a-5p. Moreover, CASC2 overexpression promoted the expression of RUNX1, while upregulated miR-18a-5p significantly reversed the effect of CASC2 on the RUNX1 level (all p < 0.05). Upregulated CASC2 may inhibit cell proliferation, migration, and invasion through regulating miR-18a-5p and its target gene RUNX1 in MM. Yes Cell viability, colony number, migration, and invasion were significantly decreased in cells with pc-CASC2 compared with cells transfected with pcDNA3.1 (all p < 0.05). 29422114 CASC2 LncRNA Homo sapiens Diabetic Nephropathies serum regulation[miR-133b/FOXP1 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay The expression of CASC2 was reduced in serum from DN patients and HG-induced HMCs.CASC2 upregulation suppressed HG-induced proliferation, ECM accumulation and oxidative stress of HMCs through miR-133b /FOXP1 regulatory axis, suggesting that CASC2 was a novel biomarker for DN treatment. Yes CASC2 upregulation inhibited HG-induced HMCs proliferation, ECM accumulation and oxidative stress. 32016985 CASC2 LncRNA Homo sapiens stomach carcinoma GC tissues and cell lines Regulation[E2F6/CASC2 axis] Flow Cytometry//qRT-PCR//Transwell Assay//Western Blot Our data revealed that CASC2 was downregulated while E2F6 was upregulated in GC tissues and cell lines. Furthermore, downregulation of E2F6 decreased the expression of MMP-2 and increased the activity of caspase-3. However, these changes triggered by E2F6 knockdown could be reversed by inhibition of CASC2. Moreover, we also proved that downregulation of CASC2 reverses the effect of E2F6 knockdown on tumor growth in vivo. Remarkably, lower expression of CASC2 was associated with poor survival in GC patients. Yes Subsequently, reliable data showed that downregulation of E2F6 suppressed the proliferation and invasion, and promoted the apoptosis of GC cells. 31301415 CASC2 LncRNA Homo sapiens Sepsis serum regulation[miR-155 and NF-κB pathway] qRT-PCR The present study demonstrated that the expression of CASC2 was significantly decreased in the serum of patients with sepsis compared with healthy subjects. In conclusion, the results of the present study suggested that CASC2 may serve as a potential target for treating sepsis‑induced AKI by inhibiting the miR‑155 and NF‑κB pathway‑mediated inflammation. Yes Further experiments revealed that CASC2 promoted cell viability and inhibited inflammatory factor secretion, apoptosis and oxidative stress in lipopolysaccharide?stimulated human renal tubular epithelial HK?2 cells. 32323747 CASC2 LncRNA Homo sapiens Asthma ASMCs Interaction(miR-31-5p) CCK8//qRT-PCR//Luciferase Report Assay//ELISA//Transwell Assay CASC2 was at a low level in asthma children in comparison with the healthy controls. Serum CASC2 can distinguish healthy individuals from asthma children. In PDGF-BB treated ASMCs, the reduced expression of contractile phenotype marker (α-SMA) was detected, but the trend was reversed by CASC2 upregulation. LncRNA CASC2 serves as a ceRNA of miR-31-5p, overexpression of miR-31-5p reversed the influence of CASC2 on asthma in vitro. Yes Overexpression of CASC2 inhibited PDGF-BB induced cell proliferation and migration. CASC2 upregulation inhibited the release of Th2 related cytokines (IL-4 and IL-10), but promoted the release of Th1-related cytokine (IFN-γ). 35185342 CASC2 LncRNA Homo sapiens Arthritis, Rheumatoid plasma regulation[downregulating IL-17] Flow Cytometry//qRT-PCR//ELISA//Western Blot Our preliminary microarray data showed that lncRNA CASC2 was downregulated in the plasma of patients with rheumatoid arthritis (RA), indicating the involvement of this lncRNA in RA.Therefore, downregulation of lncRNA CASC2 is involved in RA and lncRNA CASC2 overexpression may promote the apoptosis of HFLS by downregulating IL‑17. Yes Overexpression of lncRNA CASC2 promoted, while treatment with IL?17 inhibited the apoptosis of human fibroblast?like synoviocytes (HFLSs) isolated from RA patients. 32186765 CASC2 LncRNA Homo sapiens Arthritis, Rheumatoid patients with RA Interaction(miR-18a-5p/BTG3 signaling axis ) Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//ELISA Compared with the healthy subjects, lncRNA CASC2 was downregulated, whereas miR-18a-5p was upregulated in patients with RA. Overall, lncRNA CASC2 alleviated RA by adjusting the miR-18a-5p/BTG3 signaling axis and could serve as a novel therapeutic option for RA. Yes Overexpression of lncRNA CASC2 decreased the viability of human fibroblast-like synoviocytes (HFLSs) and induced apoptosis, as revealed by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and flow cytometry analyses. F 35045800 CASC2 LncRNA Homo sapiens Pulmonary Disease, Chronic Obstructive Serum of fifty smokers with COPD and another 50 smokers without COPD Interaction(miR-18a-5p/IGF1 axis) CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//ELISA Serum CASC2 was dramatically decreased in COPD patients compared with smokers without COPD, and was positively associated with FEV1 (forced expiratory volume in one second). CASC2 was overexpressed in severe COPD patients, and had the diagnostic accuracy to distinguish COPD patients from smokers. CASC2 functions as a ceRNA of miR-18a-5p. Upregulation of miR-18a-5p reversed the influence of CASC2 on cell apoptosis and inflammation in 16HBE cells. IGF1 was the target gene of miR-18a-5p. Yes CASC2 overexpression alleviated CSE-induced apoptosis and inflammation in 16HBE cells. CASC2 functions as a ceRNA of miR-18a-5p. Upregulation of miR-18a-5p reversed the influence of CASC2 on cell apoptosis and inflammation in 16HBE cells. IGF1 was the target gene of miR-18a-5p. 34266334 CASC2 LncRNA Homo sapiens Diabetic Foot tissues of ulcers of DFU mice and patients Interaction(miRNA-155/HIF-1 α) Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay According to our study, the lncRNA CASC2's expression was low in the tissues of ulcers of DFU mice and patients. In addition, lncRNA CASC2 directly targets miR-155 and HIF-1α functions as miR-155's target gene. Overexpression of miR-155 abrogated the function of lncRNA CASC2. Yes lncRNA CASC2's overexpression promoted fibroblasts migration, proliferation, and inhibited apoptosis and was beneficial for the healing of wounds, preferably in the DFU mice. 35845734 CASC2 LncRNA Homo sapiens Lymphoma, Non-Hodgkin cell lines regulation[LncRNA-CASC2/miR-155-5p/APC Axis ] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay CASC2 was downregulated in NHL cell lines.Overexpression of CASC2 suppresses the proliferation and invasion of NK-92 cells, promote the apoptosis of NK-92 cells via targeting miR-155-5p and upregulating APC expression. Yes Overexpression of CASC2 could inhibit the proliferation and invasion of NK-92 cells, and promote its apoptosis. 33283723 CASC2 LncRNA Homo sapiens Acute Lung Injury Serum specimens Interaction(miR-152-3p/PDK4 Axis) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//ELISA CASC2 and PDK4 were down-regulated, while miR-152-3p was up-regulated in sepsis patients and LPS-stimulated HPAEpiC. In addition, miR-152-3p was a miRNA target of CASC2 and CASC2 alleviated cell injury in LPS-disposed HPAEpiC by sponging miR-152-3p. Moreover, miR-152-3p directly targeted PDK4 and CASC2 increased the PDK4 expression by depending on the sponge effect on miR-152-3p. Yes Overexpression of CASC2 relieved the LPS-resulted cell viability inhibition, apoptosis promotion, inflammatory and oxidative damages in HPAEpiC. 34165388 CASC2 LncRNA Homo sapiens Acute Kidney Injury sepsis patients' serums and LPS-treated HK2 and HEK293 cells Interaction(MiR-545-3p/PPARA Axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay CASC2 level was decreased in sepsis patients' serums and LPS-treated HK2 and HEK293 cells.CASC2 was identified as a sponge for miR-545-3p to regulate PPARA expression. MiR-545-3p overexpression restored the impact of CASC2 on LPS-induced injury in HK2 and HEK293 cells. Moreover, miR-545-3p overexpression aggravated LPS-induced cell injury in HK2 and HEK293 cells by targeting PPARA. Yes CASC2 overexpression facilitated cell viability and restrained cell apoptosis, migration, epithelial-mesenchymal transition (EMT) and oxidative stress in LPS-triggered HK2 and HEK293 cells. 33957574 CASC2 LncRNA Mus musculus Diabetic Nephropathies urine regulation[miR-144/SOCS2 axis] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot The expression of CASC2 in diabetic mouse models and HG-induced HRMCs was lower than that in the control (p < 0.05). CASC2 could alleviate the degree and process of apoptosis, inflammation, and fibrosis in diabetic nephropathic models by regulating the miR-144/SOCS2 axis. Yes Overexpression of CASC2 resulted in a decrease in the apoptosis rate, inflammatory factor release (TNF-α, IL-6, and IL-1β), expression of cleaved caspase-3, and fibrotic proteins (fibronectin, Col-IV, and TGF-β1) and an increase in Bcl-2 expression. 33227790 CASC2 LncRNA Homo sapiens Pancreatic Neoplasms cell lines Interaction[downregulating miR-21] qRT-PCR//Transwell Assay CASC2 expression was downregulated in the pancreatic cancer cell lines CAPAN-1, BxPC-3, JF305, PANC-1 and SW1990 compared with levels in normal human pancreatic HPDE6-C7 cells. MiR-21 was a direct target of CACS2. The overexpression of miR-21 significantly abolished the antimetastatic effects of CASC2 on PANC-1 cells. Moreover, the downregulation of PTEN significantly abolished the antimetastatic effects of CASC2. Yes CACS2 overexpression inhibited the migration and invasion of PANC-1 cells and significantly inhibited the expression of miR-21 and PTEN. 30675129 CASC2 LncRNA Homo sapiens Thyroid Cancer, Papillary tumor tissues and plasma Regulation[EMT pathway] CCK8//qRT-PCR//Western Blot//Transwell Assay We demonstrated that lncRNA CASC2 expression was significantly downregulated in tumor tissues and plasma samples in patients with PTC compared with those in nodular goiters (P< 0.05). Moreover, we demonstrated that overexpression of lncRNA CASC2 suppressed cell epithelial-mesenchymal transition (EMT) process of PTC by increasing the E-cadherin expression, but downregulating ZEB1 and N-cadherin expression. Decreased plasma lncRNA CASC2 expression associated with lymph node metastasis (LNM) of PTC patients and was identified as an independent risk for patients with LNM (P< 0.05). Yes Furthermore, functional assays demonstrated that overexpression of lncRNA CASC2 inhibited cell proliferation, migration and invasion of PTC. 30175973 CASC2 CircRNA Homo sapiens Thyroid Neoplasms thyroid cancer Interaction( miR-18a-5p/FIH1 axis) Western Blot//Transfection//Migration Assay//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay We demonstrated that CASC2 was downregulated in thyroid cancer. Bioinformatics analysis predicted that hypoxia inducible factor 1 subunit alpha inhibitor (FIH-1) was potentially targeted by miR-18a-5p, which was confirmed by luciferase reporter assay. Upregulation of FIH-1 abrogated the promotive effect of miR-18a-5p on the growth and invasion of thyroid cancer cells. Yes e noted that CASC2 overexpression restrained the growth, migration, and invasion of thyroid cancer cells, whereas CASC2 depletion caused opposite trends. 33336500 CASC2 LncRNA Homo sapiens Colonic Neoplasms cancer cell lines Interaction(miR-19a) CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Expression of lncRNA CASC2 lower in cancer cell lines and the overexpression reduced the cell viability of HT29 and SW480. Yes Furthermore, Bcl-2 was suppressed by overexpressed lncRNA CASC2, while Bax was upregulated. LC3-Ⅰ and p62 were both inhibited, but LC3-Ⅱ was promoted. MiR-19a was predicted to bind lncRNA CASC2 and expressed higher in cancer cell lines.  33983643 CASC21 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Regulation[miR-7-5p/YAP1 axis] Western Blot//Wound Healing Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay By bioinformatics analysis, CASC21 was found to be significantly up-regulated in colorectal cancer tissues.Mechanistically, CASC21 could competently bind to miR-7-5p, resulting in increased YAP1 expression. Furthermore, up-regulation of YAP1 could rescue the inhibitory effects of CASC21 knockdown on EMT and cell invasion. Yes Moreover, CASC21 knockdown displayed significant depression in cell viability, proliferation, migration, and invasion in colorectal cancer cells, as well as EMT process, while cell apoptosis was promoted by regulating the Bcl-2/Bax axis and Caspase cascade. 31731190 CASC21 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues regulation[regulating CDK6] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//ChIP CASC21 is overexpressed in CRC and high CASC21 expression is associated with poor survival.Mechanistically, we found that CASC21 expressed predominantly in the cytoplasm. CASC21 could interact with miR-539-5p and regulate its target CDK6. CASC21 is overexpressed in CRC and high CASC21 expression is associated with poor survival. Yes Functional experiments revealed that CASC21 promotes CRC cell growth. 32584787 CASC21 LncRNA Homo sapiens Colorectal Neoplasms CRC cell Interaction(miR-485-5p/POU5F1B) RNA Pull-Down//qRT-PCR//RIP//IF//Luciferase Report Assay//IHC//ChIP In addition, CASC21 was co-expressed with and bound to transcription factor POU5F1B (POU class 5 homeobox 1B). CASC21 recruited POU5F1B to HGH1 promoter to activate the transcription of HGH1 homolog. Also, CASC21 served as a competitive endogenous RNA (ceRNA) to up-regulate HGH1 via endogenously sponging miR-485-5p. Yes The results revealed that CASC21 facilitated CRC cell proliferation, migration, epithelial-mesenchymal transition (EMT) and stemness. 34375566 CASC20 LncRNA Homo sapiens Stomach Neoplasms GC tumor tissues and various GC cell lines Interaction(miR-143-5p/MEMO1 molecular axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of CASC20 was increased in GC tumor tissues and various GC cell lines.Mechanistic studies revealed that CASC20 exhibits oncogenic functions by regulating MEMO1 expression through competitive endogenous binding to miR-143-5p, leading to induction of epithelial-mesenchymal transition. High CASC20 expression was correlated with a high risk of lymphatic metastasis and poor prognosis in GC patients. Yes In vitro assays showed that silencing CASC20 reduced cell proliferation, migration, and invasion in GC cells 35581960 CASC2 LncRNA Homo sapiens Breast Neoplasms Breast Cancer tissues,cell line( HCC1937 , LCC9, MDA-MB-231,MCF-7) Interaction[TGF-β] qRT-PCR//MTT//Western Blot In the present study, lncRNA CASC2 was found to be significantly Expression[down-expression]regulated in breast cancer tissues and cell lines using real-time quantitative PCR.Additionally, based on the above research, we illustrated that inactivation of the TGF-β signaling pathway was involved in the function of lncRNA CASC2. Yes Furthermore, gain-of-function assays demonstrated that overexpression of lncRNA CASC2 significantly repressed breast cancer cell proliferation and metastasis. 29523222 CASC2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction[increasing SOCS1 ] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP In the present study, we found that CASC2 was significantly downregulated in ESCC tissues and positively correlated with overall survival time of patients with ESCC.Conclusively, these results demonstrated that CASC2 could exert as a tumor suppressive lncRNA in ESCC progression via regulating SOCS1. In the present study, we found that CASC2 was significantly downregulated in ESCC tissues and positively correlated with overall survival time of patients with ESCC. Yes Functional assays demonstrated that CASC2 suppressed proliferation, migration and invasion, as well as enhanced drug sensitivity in ESCC cells. 31728180 CASC2 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-18a-5p/BTG3 Pathway) Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay CASC2 was decreased in CRC tissues and cell lines, and its low expression in CRC tissues was associated with larger tumor size and lymph node metastasis. CASC2 could function as a molecular sponge for miR-18a-5p and repress the expression of miR-18a-5p. Furthermore, the inhibitory effects of CASC2 on the malignant phenotypes of CRC cells was counteracted by miR-18a-5p mimics. Additionally, CASC2 could positively regulate BTG3 expression via suppressing miR-18a-5p. Yes CASC2 overexpression restrained proliferative, migrative and invasive capabilities of CRC cells. 36377216 CASC2 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues and cell lines regulation[TRIM16 expression] qRT-PCR//Luciferase Report Assay//Western Blot The gene expression analysis showed that LncRNA CASC2 is significantly suppressed in colon cancer tissues and cell lines. Additionally, silencing of TRIM16 resulted in the inhibition of HT-29 cell growth similar to that of CASC2 overexpression. Yes Overexpression of CASC2 inhibited the growth of HT-29 cells. 32655801 CASC2 LncRNA Homo sapiens Osteoarthritis blood Interaction[IL-17] qRT-PCR Our new findings showed that both lncRNA CASC2 and IL-17 were up-regulated in plasma of osteoarthritis patients. Therefore, lncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis. ® Yes In addition, overexpression of lncRNA CASC2 inhibited the proliferation, and promoted the apoptosis of chondrocyte. 31015370 CASC2 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues,cell lines interaction[ sponging miR-24-3p] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay CASC2 was significantly downregulated in thyroid cancer. In addition, upregulation of CASC2 could inhibit the tumorigenesis of TC via sponging miR-24-3p. Yes Overexpression of CASC2 inhibited the proliferation, migration, and invasion of thyroid cancer cells. 33194032 CASC2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Expression[lower expressed] Western Blot//Wound Healing Assay//Flow Cytometry//Colony Formation Assay//Transwell Assay In tissues and cells of HCC, decreased CASC2 expressions were confirmed. Yes Meanwhile, the overexpression of CASC2 played significant roles in inhibiting the proliferation, migration, and invasion of HCC cells. Furthermore, In vivo experiment indicated that CASC2 restrained the growth of tumors. 30362539 CASC2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation[Wnt/β-catenin signaling pathway] qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CASC2 was down-regulated in HCC tissues and cell lines, while miR-183 was up-regulated. Overexpression of CASC2 inhibited cell viability, colony formation, migration, and invasion in HCC cells, as well as Wnt/β-catenin signaling pathway activity. CASC2 inhibited cell viability and the colony formation, migration, and invasion abilities of HCC cells by directly downregulating miR-183 through inactivation of the Wnt/β-catenin signaling pathway. Yes Overexpression of CASC2 inhibited cell viability, colony formation, migration, and invasion in HCC cells, as well as Wnt/β-catenin signaling pathway activity. 31538425 CASC2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissue Interaction[PDCD4 ] qRT-PCR//MTT//Luciferase Report Assay//Western Blot The results demonstrated that CASC2 was significantly downregulated in clinical OSCC tissue samples and cultured OSCC cell lines.Furthermore, bioinformatics analysis and dual-luciferase reporter assay showed that CASC2 might act as a competing endogenous RNA of miR-21 to promote the expression of PDCD4. Rescue experiments also showed that miR-21 blocked the tumor-suppressive role that CASC2 exerted in OSCC cells. Finally, in vivo study indicated that overexpression of CASC2 restrained OSCC tumor growth in volume and weight. Yes Functionally, overexpression of CASC2 remarkably inhibited cell proliferation partly through inducing cell cycle arrest and cell apoptosis. 31123403 CASC2 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Interaction[MAPK pathway] CCK8//qRT-PCR//Western Blot CASC2 levels in human cervical cancer tissues and cell lines were significantly downregulated compared to para-cancerous tissues and the immortalized human keratinocyte line HaCaT. Moreover, the expression of p-JNK and p-ERK1 levels in the MAPK pathway was significantly decreased in pcDNA3.1-CASC2 group. Yes Compared to scramble group, CASC2 overexpression significantly inhibited the proliferation, migration, invasion, and angiogenesis of cervical cancer cells. However, the inhibition of CASC2 had the opposite effect. 31081078 CASC2 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues, cell lines Regulation[CASC2/miR‑18a‑5p axis] CCK8//qRT-PCR//Luciferase Report Assay//RIP We showed that the CASC2 level is reduced in NPC tissues and cells.There were putative binding sites of microRNA (miR)‑18a‑5p in the promoter of CASC2. The level of miR‑18a‑5p was upregulated in NPC tissues and cells. We further confirmed that CASC2 could directly bind with miR‑18a‑5p and inhibit miR‑18a‑5p expression, using reporter gene and RNA immunoprecipitation assays. miR‑18a‑5p suppressed CASC2 upregulation‑mediated decrease in proliferation and increase in apoptotic cell death. Bioinformatics predicted the putative binding site of miR‑18a‑5p in the 3' untranslated region of C‑terminal binding protein interacting protein (CtIP)/RBBP8. It was further confirmed that miR‑18a‑5p could directly bind with RBBP8 and inhibit RBBP8 expression. Downregulation of RBBP8 inhibited the anti‑miR‑18a‑5p‑mediated increase in apoptosis and decrease in proliferation. Downregulation of CASC2 increased tumor growth, increased the level of miR‑18a‑5p and decreased RBBP8 expression in vivo. In summary, CASC2 regulates NPC malignancy through modulation of RBBP8 via sponging miR‑18a‑5p. Yes CASC2 downregulation promoted proliferation and inhibited apoptotic cell death in NPC cells. In contrast, CASC2 upregulation inhibited proliferation and increased apoptosis. 30569153 CASC2 LncRNA Homo sapiens Glioblastoma glioblastoma tumor tissues and cells (T98 and A172) regulation[CASC2- miR-18a axis] Western Blot//Flow Cytometry//qRT-PCR//RIP//Colony Formation Assay//Transwell Assay As a result, CASC2 was downregulated and miR-18a was upregulated in glioblastoma tumor tissues and cells (T98 and A172). Collectively, this study demonstrated that CASC2 served as tumor suppressor in glioblastoma by inhibiting cell growth, metastasis and EMT both in vitro and in vivo partially via CASC2- miR-18a axis. Yes Overexpression of CASC2 promoted apoptosis rate and E-cadherin expression, but suppressed cell viability, colony-forming ability, migration, invasion, and expression of N-cadherin and Vimentin in T98 and A172 cells, accompanied with tumor growth inhibition in vivo; whereas, silencing of CASC2 exerted the opposite effect on cell growth, metastasis and EMT of T98 and A172 cells in vitro. 32975234 CASC2 LncRNA Homo sapiens Atherosclerosis blood regulation[miR-532-3p/PAPD5] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression levels of CASC2 were decreased, while the expression levels of miR-532-3p were elevated in AS patient samples and VSMCs.CASC2 suppressed cell reproduction and promoted cell apoptosis by regulating the miR-532-3p/PAPD5 axis in ox-LDL-mediated VSMCs. This might be important for AS therapeutics. Yes Overexpression of CASC2 inhibited the proliferation and migration of VSMCs and enhanced cell apoptosis. 32698757 BRE-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Interaction(miR-21) RNA Pull-Down//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay//Invasion Assay//Transwell Assay BRE-AS1 was downregulated in TNBC, while miR-21 was highly expressed in TNBC. Low expression levels of lncRNA BRE-AS1 and high expression levels of miR-21 were significantly correlated with unfavorable survival outcomes. BRE-AS1 and miRNA-21 were inversely correlated across TNBC samples, not control samples. BRE-AS1 decreased miR-21 expression and increased PTEN expression while miR-21showed no role in BRE-AS1 expression. RNA pull-down assay illustrated that BRE-AS1 may sponge premature miR-21 to suppress it maturation. Yes Overexpression of BRE-AS1 decreased cell behaviors, while overexpression of miR-21 promoted cell behaviors. MiR-21 34182945 BRE-AS1 LncRNA Homo sapiens prostate carcinoma prostate carcinoma tissues Interaction[miR-145-5p] CCK8//PCR In the present study we found that plasma BRE-AS1 and miR-145-5p were both down-regulated in PC patients than in healthy controls.BRE-AS1 overexpression mediated miR-145-5p Expression[up-expression]-regulation in PC cells, while miR-145-5p overexpression did not significantly affect BRE-AS1. miR-145-5p inhibitor attenuated the effects of BRE-AS1 overexpression on cancer cell behaviors. Down-regulation of BRE-AS1 and miR-145-5p effectively distinguished early-stage PC patients from healthy controls. Yes Overexpression of BRE-AS1 and miR-145-5p led to inhibited proliferation and promoted apoptosis of PC cells. 30833361 BORG LncRNA Homo sapiens Breast Neoplasms murine and human TNBC cells Interaction(TRIM28 complexes ) Flow Cytometry//qRT-PCR//RNA-seq Indeed, we found BORG expression to: (i) correlate with stem cell markers Nanog, Aldh1a3, and Itga6 (α6 integrin/CD49f); (ii) enhance stem cell phenotypes in murine and human TNBC cells, and (iii) promote TNBC tumor initiation in mice. Collectively, these findings implicate BORG:TRIM28 complexes as novel drivers of BCSC phenotypes in developing and progressing TNBCs. Yes Indeed, we found BORG expression to: (i) correlate with stem cell markers Nanog, Aldh1a3, and Itga6 (α6 integrin/CD49f); (ii) enhance stem cell phenotypes in murine and human TNBC cells, and (iii) promote TNBC tumor initiation in mice. 34497119 B3GALT5-AS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Regulation[B3GALT5-AS1/miR-203/EMT axis] qRT-PCR In this study, we identified a novel lncRNA B3GALT5-AS1, which is reduced in colon cancer tissues and further reduced in colon cancer liver metastasis tissues.Our data suggested that the activating B3GALT5-AS1/miR-203/EMT axis may be potential therapeutic strategy for colon cancer liver metastasis. Reduced expression of B3GALT5-AS1 is associated with liver metastasis and poor outcome of colon cancer patients. Yes Gain-of-function and loss-of-function assays revealed that B3GALT5-AS1 inhibited proliferation but promoted migration and invasion of colon cancer cells. 30530918 AY343892 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells regulation[BRCA1-mediated transcription of PTEN] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//ChIP In this research, we found that lncRNA AY343892 was significantly down-regulated in breast cancer tissues and cells. In conclusion, this study illustrated that AY343892 inhibited breast cancer development by positively regulating BRCA1-mediated transcription of PTEN. Yes Functional assays indicated that overexpression of AY343892 significantly inhibited proliferation and promoted apoptosis in breast cancer cells. 32754899 AXL CircRNA Homo sapiens Alzheimer Disease AD models, cell line Interaction(miR-328/BACE1) Western Blot//Transfection//qPCR//PCR//IF Additionally, circ-AXL negatively regulated miR-328 but positively modulated BACE1; besides, miR-328 negatively regulated BACE1; further luciferase reporter gene assay presented that circ-AXL directly bound miR-328, and miR-328 directly bound BACE1. Furthermore, miR-328 overexpression decreased apoptosis rate, elevated neurite outgrowth, and declined inflammatory cytokines in cellular AD models; but miR-328 knockdown presented opposite effects. Notably, miR-328 knockdown attenuated the effect of circ-AXL knockdown on cellular AD models. Yes Circ-AXL overexpression increased apoptosis rate and declined neurite outgrowth, as well as elevated inflammatory cytokines in cellular AD models; but circ-AXL knockdown exhibited opposite effects. 35167942 AWPPH LncRNA Homo sapiens Stomach Neoplasms GC tissues and adjacent normal tissues Regulation[miR-203a/DKK2 axis] qRT-PCR//Luciferase Report Assay//Western Blot It turned out that lncRNA AWPPH was significantly decreased in GC tissues, comparing to adjacent noncancerous gastric tissues. Upregulation of miR-203a attenuated the repressive effects of AWPPH on GC cell proliferation and invasion. AWPPH inhibited GC cell proliferation and invasion via miR-203a/DKK2 axis. Yes CCK8 and transwell assays proved that AWPPH inhibited cell proliferation and invasion in GC cells. 31489578 AWPPH LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[ TGF-β1] qRT-PCR//ELISA//Western Blot It was observed that AWPPH was significantly Expression[Expression[up-expression]-expression]regulated in patients with NSCLC, while AWPPH expression level did not increase with the increase of tumor size. AWPPH overexpression promoted TGF-β1 expression in NSCLC cells, while TGF-β1 treatment showed no significant effects on AWPPH expression. AWPPH overexpression promoted NSCLC cell migration and invasion, while TGF-β signaling inhibition reduced this enhancing effect. Yes AWPPH overexpression promoted TGF-β1 expression in NSCLC cells, while TGF-β1 treatment showed no significant effects on AWPPH expression. AWPPH overexpression promoted NSCLC cell migration and invasion, while TGF-β signaling inhibition reduced this enhancing effect. 31516619 AWPPH LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues interaction[miRNA-204 ,CDK6] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Upregulated AWPPH and downregulated miRNA-204 were determined in NSCLC tissues. LncRNA AWPPH serves as the miRNA-204 sponge to upregulate CDK6 level, thus aggravating the progression of NSCLC. AWPPH level was negatively correlated to overall survival in NSCLC patients and miRNA-204 level in NSCLC tissues. Yes Silence of AWPPH attenuated proliferative, migratory, and invasive capacities in A549 cells. 32373964 AWPPH LncRNA Homo sapiens Colonic Neoplasms cc tissues Interaction[GLUT-1] CCK8//qRT-PCR//ELISA//Western Blot It was observed that serum levels of lncRNA AWPPH and GLUT-1 were significantly higher in patients with colon cancer patients compared with healthy controls. AWPPH-silencing significantly inhibited GLUT-1 expression and inhibited cancer cell proliferation. GLUT-1 overexpression promoted cancer cell proliferation and attenuated the inhibitory effects of AWPPH-silencing on cancer cell proliferation. Yes Furthermore, AWPPH-silencing significantly inhibited GLUT-1 expression and inhibited cancer cell proliferation. GLUT-1 overexpression promoted cancer cell proliferation and attenuated the inhibitory effects of AWPPH-silencing on cancer cell proliferation. 31423271 AWPPH LncRNA Homo sapiens Carcinoma, Hepatocellular bone marrow interaction[ROCK2 ] CCK8//qRT-PCR//Western Blot The results of the present study revealed that the expression levels of lncRNA AWPPH and Rho-associated protein kinase 2 (ROCK2) were upregulated in the bone marrow of patients with pediatric T-cell acute lymphoblastic leukemia compared with healthy controls. Yes lncRNA AWPPH and ROCK2 overexpression promoted the proliferation and inhibited the apoptosis of Loucy cells, an acute lymphoblastic leukemia cell line. 32973953 AWPPH LncRNA Homo sapiens colorectal adenocarcinoma colorectal adenocarcinoma tissues Interaction[TGF-β1] qRT-PCR AWPPH was significantly upregulated in tumor tissues compared with adjacent healthy tissues.AWPPH overexpression promoted and silencing inhibited TGF-β1 expression. Therefore, lncRNA-AWPPH promoted colorectal adenocarcinoma by promoting tumor growth, increasing tumor cell viability and activating the TGF-β1 signaling. Yes AWPPH overexpression in colorectal adenocarcinoma cell lines promoted cell proliferation and increased cell viability, while AWPPH silencing resulted in opposite effects. 31611981 AWPPH LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction[PI3K/AKT pathway] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay The results demonstrated that AWPPH was highly expressed in OS tissues and cells.Furthermore, AWPPH downregulation significantly inhibited the PI3K/AKT pathway. The present study demonstrated that AWPPH was highly expressed in OS, and that AWPPH promoted OS cell proliferation and migration, and inhibited OS cell apoptosis, which may be mediated by PI3K/AKT pathway activation. Yes Functional analyses revealed that AWPPH depletion significantly inhibited OS cell proliferation and migration, and promoted OS cell apoptosis. 31612016 AWPPH LncRNA Homo sapiens Osteosarcoma OS tissues Regulation[miR-93-3p/FZD7 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this research, results indicated AWPPH levels were increased in OS tissues in contrast to paracancerous controls.Mechanistically, AWPPH was demonstrated to sponge miR-93-3p and promote FZD7 expression, causing activation of Wnt/β-catenin. Inhibition of miR-93-3p effectively reversed the effects of AWPPH knockdown on OS cells. Collectively, our findings suggested AWPPH may be a prognostic biomarker and potential therapeutic target. AWPPH enhances FZD7-mediated activation of Wnt/β-catenin by sponging miR-93-3p to promote OS progression. Up-regulated AWPPH was associated with advanced stage, tumor size and metastasis. Besides, AWPPH up-regulation indicated a low survival rate in OS patients. Yes Silencing of AWPPH suppressed proliferation, migration and invasion of OS cells. 31092328 AWPPH LncRNA Homo sapiens Triple Negative Breast Neoplasms blood Interaction[miRNA-21] CCK8//qRT-PCR//MTT The current study aimed to explore the involvement of AWPPH in triple-negative breast cancer (TNBC). In the current study, we found that plasma levels of lncRNA AWPPH and microRNA-21 (miRNA-21) were Expression[Expression[up-expression]-expression]regulated in patients with TNBC than in healthy controls, and the Expression[Expression[up-expression]-expression]regulation of plasma lncRNA AWPPH and miRNA-21 distinguished early-stage patients with TNBC from healthy controls Yes LncRNA AWPPH and miRNA-21 overexpression led to promoted cancer cells proliferation and improved cancer cell viability under carboplatin treatment, while lncRNA AWPPH small interfering RNA (siRNA) silencing played an opposite role. In addition, miRNA-21 overexpression attenuated the effects of lncRNA AWPPH siRNA silencing on of cancer cell behaviors. LncRNA AWPPH overexpression led to Expression[Expression[up-expression]-expression]regulated miRNA-21 in TNBC cells, while miRNA-21 overexpression also led to significantly Expression[Expression[up-expression]-expression]regulated lncRNA AWPPH expression. 31033015 AWPPH LncRNA Homo sapiens Glioma blood Interaction[TGF-β pathway] qRT-PCR//ELISA//Western Blot//Transwell Assay It was identified that AWPPH expression levels in tumor tissues were higher in patients with metastatic glioma.The plasma levels of AWPPH were positively correlated with the plasma levels of TGF-β1 in patients with glioma but not in healthy controls. In addition, AWPPH overexpression enhanced cancer cell migration and invasion, and upregulated TGF-β1 expression. Treatment with TGF-β1 demonstrated no significant effect on AWPPH expression; however, a TGF-β inhibitor attenuated the effects of AWPPH overexpression on cell migration and invasion. Therefore, the present study proposed that AWPPH may promote the migration and invasion of glioma cells by activating the TGF-β pathway. Yes In addition, AWPPH overexpression enhanced cancer cell migration and invasion, and upregulated TGF-β1 expression. 31788066 AWPPH LncRNA Homo sapiens Nasopharyngeal carcinoma NPC cells interaction[interacting with LSD1 and EZH2] ChIP//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//EdU Staining//Transwell Assay In this study, AWPPH expression was markedly upregulated in NPC cells. Collectively, our study shows that AWPPH inhibits PTEN expression to drive NPC progression through interacting with LSD1 and EZH2, providing potential biomarkers for NPC treatment. Yes Further, loss- and gain-of-function assays indicated that AWPPH facilitates cell proliferation and migration and hinders apoptosis in NPC cells. 32663416 AWPPH LncRNA Homo sapiens ovarian carcinoma ovarian carcinoma tissues,blood Regulation[Wnt/β‑catenin signaling pathway] CCK8//qRT-PCR//Western Blot//Transwell Assay It was revealed that the expression levels of AWPPH were significantly upregulated in OC tissues and serum compared with healthy controls. Therefore, it was revealed that AWPPH may promote OC via activation of the Wnt/β‑catenin signaling pathway. The serum levels of AWPPH were able to effectively diagnose and predict the prognosis of patients with OC.  Yes AWPPH overexpression promoted the proliferation, migration and invasion of OC cells, and upregulated β‑catenin expression. Treatment with a Wnt agonist markedly altered AWPPH expression; however, inhibition of Wnt suppressed the effects of AWPPH overexpression on proliferation, migration and invasion of OC cells. 30896797 AWPPH LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung tissues,blood Regulation[Wnt/β‑catenin signaling pathway] Cell Proliferation Assay//qRT-PCR//Cell Apoptosis Assay//Western Blot The results demonstrated that AWPPH expression levels were significantly upregulated in the lung tissues and serum samples of patients with NSCLC compared with in healthy controls. Therefore, it was concluded that lcRNA AWPPH could promote the growth of NSCLCs by activating the Wnt/β‑catenin signaling pathway. In addition, patients with high expression levels of AWPPH had significantly shorter survival time. Yes AWPPH overexpression in NSCLC cells promoted proliferation and inhibited apoptosis, and activated the Wnt/β‑catenin signaling pathway, which is a classic signaling pathway involved in the development and progression of different types of cancers. 30942396 AWPPH LncRNA Homo sapiens Osteoporosis osteoporosis patients Expression(lower expressed) qRT-PCR//Transfection//Western Blot We observed that the expression of lncRNA AWPPH was downregulated in osteoporosis patients than that in healthy controls. Downregulated expression of lncRNA AWPPH distinguished osteoporosis patients from healthy controls. Yes In vitro cell experiments showed that knockdown of lncRNA AWPPH led to upregulated α1 but downregulated expression of α2 in osteoblasts, which made the α1 to α2 ratio higher than 2:1. In contrast, overexpression of lncRNA AWPPH led to downregulated α1 but upregulated α2 in osteoblasts, which made the α1 to α2 ratio lower than 2:1. 32552067 AWPPH LncRNA Homo sapiens Femur Head Necrosis mesenchymal stem cells,blood Regulation[upregulating Runx2] qRT-PCR It was demonstrated that AWPPH was significantly downregulated in non-traumatic ONFH patients compared with in healthy controls in both MSCs and serum.Therefore, it was concluded that lncRNA AWPPH may participate in the development of ONFH by upregulating Runx2. Yes AWPPH overexpression promoted, while AWPPH short hairpin RNA silencing inhibited the expression of Runx2 expression in hMSC-BM cells. 31853285 AURKAP1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCCtissues Interaction[regulating miR-142, miR-155 and miR-182] qRT-PCR//Luciferase Report Assay//Western Blot The mRNA expression of AURKAPS1 in HCC tumor tissues was significantly higher, which is associated with tumor size and TNM stage. AURKAPS1 can increases the protein expression of RAC1, promotes the activation of ERK, and enhance the formation of membrane ruffles by binding with miR-182, miR-155 and miR-142 competively. Thus, AURKAPS1 could be a useful marker, and the combination of AURKAPS1/miRNAs (miR-142, miR-155 and miR-182) may be a new theoretical basis for the treatment of HCC. The mRNA expression of AURKAPS1 in HCC tumor tissues was significantly higher, which is associated with tumor size and TNM stage. Yes The high expression of AURKAPS1 promotes cell movement, migration and invasion. 31873123 B3GALT5-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-934/UFM1 Axis) CCK8//qRT-PCR//Western Blot We found that the B3GALT5-AS1 expression level was of significant reduction in both HCC tissues and cell lines; B3GALT5-AS1 overexpression (ov) may inhibit the malignant features of HCC. Our results demonstrated that B3GALT5-AS1 was an excellent HCC suppressant by regulating miR-934 and UFM1 to achieve negative regulation of HCC cell proliferation, invasion, and metastasis, indicating that B3GALT5-AS1 is a promising potential therapeutic target for HCC treatment. We found that the B3GALT5-AS1 expression level was of significant reduction in both HCC tissues and cell lines; B3GALT5-AS1 overexpression (ov) may inhibit the malignant features of HCC. Yes Our results demonstrated that B3GALT5-AS1 was an excellent HCC suppressant by regulating miR-934 and UFM1 to achieve negative regulation of HCC cell proliferation, invasion, and metastasis, indicating that B3GALT5-AS1 is a promising potential therapeutic target for HCC treatment. 34721576 B3GALT5-AS1 LncRNA Homo sapiens Stomach Neoplasms MKN-45 cells Regulation(CSNK2A1) RNA Pull-Down//Western Blot//Invasion Assay//Migration Assay//CCK8//RIP//qRT-PCR//Cell Apoptosis Assay//Bioinformatics Analysis The results showed that B3GALT5-AS1 expression was upregulated in MKN-45 cells compared with the control group. In addition, B3GALT5-AS1 could bind to CSNK2A1 to regulate its expression.B3GALT5-AS1 knockdown attenuated cell viability, invasion and migration, whilst promoting cell apoptosis. These effects were partly reversed by CSNK2A1 overexpression. Yes B3GALT5-AS1 knockdown attenuated cell viability, invasion and migration, whilst promoting cell apoptosis. These effects were partly reversed by CSNK2A1 overexpression. 34306196 BANCR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells regulation[IGF1R/Raf/MEK/ERK pathway] qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay It was found that BANCR and IGF1R were upregulated, while miR?338?3p was downregulated in ESCC tissues and cells.On the whole, the findings of the present study demonstrate that BANCR inhibition blocks ESCC progression by inactivating the IGF1R/Raf/MEK/ERK pathway by sponging miR‑338‑3p. Yes Both BANCR and IGF1R knockdown suppressed the proliferation, migration, invasion and epithelial?mesenchymal transition (EMT) of ESCC cells. IGF1R enhancement reversed BANCR knockdown?mediated effects on the proliferation, migration, invasion and EMT of ESCC cells. 32945416 B4GALT1-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells spheres Regulation[YAP] RIP//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Transwell Assay LncRNA B4GALT1-AS1 expression was significantly increased in OS tissues and cells spheres. Mechanistically, B4GALT1-AS1 recruited HuR to enhance YAP mRNA stability and thus its transcriptional activity. Yes Knockdown of B4GALT1-AS1 inhibited OS cells proliferation, migration, stemness and chemotherapeutic sensitivity. 30182452 BANCR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(LINC00586/LSD1/ASXL1 axis ) qRT-PCR LINC00586 was overexpressed in CRC tissues and associated with patient survival. Overall, discovery of the LINC00586/LSD1/ASXL1 axis partially explains epigenetic mechanism regulating EMT in CRC, providing a therapeutic target to limit CRC metastasis. LINC00586 was overexpressed in CRC tissues and associated with patient survival. Yes LINC00586 knockdown repressed HCT116 and LoVo cell viability, migration, their phenotypic switch from epithelial to a mesenchymal, and tumorigenesis in vivo. 35586041 BANCR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines regulation[MAPK signaling pathway] qRT-PCR In this study, we found that the expression of BANCR was upregulated in OSCC tissues and cell lines compared to the negative control. The results also showed that the expression of MAPK signaling-related proteins (p-erk, p-akt, and p-p-38) was positively correlated with that of BANCR. Yes The decreased expression of BANCR in vitro markedly inhibited OSCC cell proliferation, migration, and invasion while the opposite was observed for the overexpression of BANCR. 31654433 BANCR LncRNA Homo sapiens Atherosclerosis plasma and HASMCs Interaction(miR-34c methylation ) CCK8//qRT-PCR//Transfection//Luciferase Report Assay In this study, we found that BANCR was upregulated, while miR-34c was downregulated in atherosclerosis.Bioinformatics analysis showed that BANCR and miR-34c could directly interact with each other. Moreover, overexpression of BANCR could decrease the expression of miR-34c in HASMCs, but overexpression of miR-34c could not affect the expression of BANCR. Furthermore, overexpression of BACNR increased miR-34c methylation, and knockdown of endogenous BANCR decreased miR-34c methylation. Yes In addition, overexpression of BANCR reduced the effects of miR-34c on HASMCs proliferation and reversed the effects of miR-34c on HMGB1, TNF-ɑ and Bcl-2 expression. BANCR overexpression could induce HASMCs proliferation by downregulating the miR-34c methylation. 33151462 BANCR LncRNA Homo sapiens Thyroid Cancer, Papillary thyroid tumor tissues Regulation[RAF/MEK/ERK signaling pathway] Flow Cytometry//qRT-PCR//Western Blot We observed that BANCR was expressed at a higher level in human thyroid tumor tissues than that noted in the adjacent normal tissues.Taken together, these results suggest that BANCR plays a role in PTC development by regulating the expression of cancer stem cell markers LGR5 and EpCAM via the c-Raf/MEK/ERK signaling pathway. Yes In the xenograft mouse model, BANCR overexpression in the thyroid cancer cells significantly increased tumor growth. 29917164 BANCR LncRNA Homo sapiens Pancreatic Neoplasms SW1990 and PANC-1 PC cell lines Interaction(HIF-1α/VEGF-C/VEGFR-3 pathway ) qRT-PCR//Transfection//Western Blot The results showed that the expression of BANCR in the SW1990 and PANC-1 PC cell lines was significantly higher than that in human pancreatic duct endothelial cells. Additionally, the expression of BANCR was significantly increased in PC cells under hypoxic conditions compared with normoxic conditions. These results indicate that BANCR positively regulated the expression of HIF-1α in PC cells at the transcriptional and translational levels. Finally, the expression levels of VEGF-C and VEGFR-3 in PC cells were significantly reduced when BANCR or HIF-1α expression was knocked down. Yes These results indicate that BANCR positively regulated the expression of HIF-1α in PC cells at the transcriptional and translational levels. Finally, the expression levels of VEGF-C and VEGFR-3 in PC cells were significantly reduced when BANCR or HIF-1α expression was knocked down. 36284647 BANCR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines Expression[highly expressed] Western Blot//CCK8//qRT-PCR//BrdU//IHC//Transwell Assay Overexpression of BANCR in these six NSCLC cell lines attenuated the cell viability and invasion. Yes Furthermore, we identified the effect of BANCR overexpression on tumor growth in NSCLC mouse model. 31114383 BANCR LncRNA Homo sapiens Polycystic Ovary Syndrome granulosa cells Interaction[upregulation of Bax and p53] CCK8//qRT-PCR//MTT//Western Blot The results revealed that the expression levels of lncRNA BANCR in GCs were significantly higher in patients with PCOS compared with in non‑PCOS patients.Transfection with the BANCR expression vector significantly inhibited proliferation and promoted apoptosis of KGN cells, and significantly promoted the expression levels of pro‑apoptotic Bax and p53. Yes Transfection with the BANCR expression vector significantly inhibited proliferation and promoted apoptosis of KGN cells, and significantly promoted the expression levels of pro‑apoptotic Bax and p53. 30592281 BAIAP2-DT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Interaction(miR-361-3p/SOX4 Axis) CCK8//qRT-PCR//Colony Formation Assay//EdU Staining In this study, the expressions of BAIAP2-AS1 and SOX4 were distinctly upregulated in HCC cells and tissues, and high BAIAP2-AS1 may be a novel biomarker for HCC. E2F1 activated BAIAP2-AS1 expression. Assays for relationship verification showed that BAIAP2-AS1 regulated the expression of SOX4 and miR-361-3p. Rescue experiments further confirmed the positive interaction between miR-361-3p and BAIAP2-AS1 as well as between miR-361-3p and SOX4. In this study, the expressions of BAIAP2-AS1 and SOX4 were distinctly upregulated in HCC cells and tissues, and high BAIAP2-AS1 may be a novel biomarker for HCC. Yes The silence of BAIAP2-AS1 inhibited the proliferation and metastasis of HepG2 and PLC5 cells. 34616498 BACE1-AS LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-377-3p/CELF1 axis) Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay This study found that BACE1-AS was overexpressed in HCC tissues and cell lines. MiR-377-3p was negatively modulated by BACE1-AS in HCC tumor tissues and cells. Moreover, CELF1 was identified as a downstream regulator of miR-377-3p and served as an oncogene in HCC cells. Yes Knockdown of BACE1-AS could restrain HCC progression in vitro, and inhibit pulmonary metastasis in vivo. 33667514 BACE1-AS LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines, HCC tissues, and serum samples of HCC patients Interaction(miR-214-3p/APLN axis) qRT-PCR In the present study, we found that the relative expression of BACE1-AS in HCC cell lines, HCC tissues, and serum samples of HCC patients was significantly increased, and its high expression was correlated with the poor prognosis of HCC patients.These findings suggest that the BACE1-AS/miR-214-3p/APLN axis is a novel signaling pathway that facilitates HCC. In the present study, we found that the relative expression of BACE1-AS in HCC cell lines, HCC tissues, and serum samples of HCC patients was significantly increased, and its high expression was correlated with the poor prognosis of HCC patients. Yes In addition, overexpression of BACE1 promoted HCC cell proliferation, cell cycle progression, migration, and invasion, but inhibited cell apoptosis, while knockdown of BACE1 exerted the opposite role. 34636395 BACE1-AS LncRNA Homo sapiens Osteosarcoma OS cells Interaction(miR-762/SOX7 axis) qRT-PCR//Western Blot//Transwell Assay In addition, LncRNA BACE1-AS is validated as a sponge of miR-762 through the prediction of lncRNASNP. Further, luciferase reporter and RIP assays are conducted to confirm the binding sites between LncRNA BACE1-AS and miR-762. SRY-box transcription factor 7 (SOX7) target to miR-762 and regulated by LncRNA BACE1-AS. Moreover, inhibition of miR-762 attenuate the role of sh-LncRNA BACE1-AS in OS cells, at meanwhile reduce the expression of SOX7. Yes Furthermore, using Cell counting kit-8 (CCK-8), transwell, wound healing and westernblot assays, overexpression LncRNA BACE1-AS remarkably reduce cell proliferation, migration and invasion abilities in OS. 35332412 BACE1-AS LncRNA Homo sapiens Parkinson Disease SH-SY5Y cells Interaction(miR-214-3p/CDIP1 signaling axis) qRT-PCR//Luciferase Report Assay Results suggested that lncRNA BACE1-AS was over-expressed and miR-214-3p was under-expressed in MPP+-stimulated SH-SY5Y cells.In addition, we found that CDIP1 was directly targeted by miR-214-3p and up-regulated in MPP+-stimulated SH-SY5Y cells. Further functional assays suggested that CDIP1-plasmid reversed the effects of miR-214-3p mimic on MPP+-stimulated SH-SY5Y cells. Yes Further analyses revealed that MPP+ inhibited cell viability; enhanced cell apoptosis, Cleaved Caspase-3 expression and Cleaved Caspase-3/GAPDH ratio; induced oxidative stress and inflammation in SH-SY5Y cells were inhibited by lncRNA BACE1-AS-siRNA transfection; and all these inhibitions were reversed by miR-214-3p inhibitor. 35481549 BACE1-AS LncRNA Homo sapiens Alzheimer Disease blood samples from AD patients Expression[highly expressed] CCK8//qRT-PCR//ELISA//Western Blot It was demonstrated that lncRNA BACE1-AS expression was highly expressed in blood samples from AD patients, and also upregulated in peripheral blood samples and hippocampi from an AD animal model. Yes Knockdown of BACE1-AS by short interfering RNA increased the primary hippocampal neurons proliferation in vitro. Knockdown of BACE1-AS mediated by lentivirus in vivo improved the memory and learning behaviors of SAMP8 mice, inhibited BACE1 and amyloid precursor protein production, and phosphorylation of tau protein in hippocampi. 30186443 BACE1-AS LncRNA Homo sapiens Alzheimer Disease blood regulation[iR-214-3p/ATG5 Signalling Axis] qRT-PCR The BACE1-AS level was found to be upregulated in serum samples of AD patients, brain tissues of AD transgenic (Tg) mice and Aβ1-42-treated SH-SY5Y cells.Our findings demonstrate that silencing of BACE1-AS alleviated neuronal injury by regulating autophagy through the miR-214-3p/ATG5 signalling axis in AD. Yes BACE1-AS knockdown alleviated Aβ1-42-induced cell injury. 33197504 BAALC-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma Interaction(G3BP2/c-Myc feedback loop ) RNA Pull-Down//Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay The expression of BAALC-AS1 was highly up-regulated and associated with malignant phenotypes in ESCC tissues and cell lines. BAALC-AS1 directly interacted with G3BP2, and thereby inhibited the degradation of c-Myc RNA 3'-UTR by G3BP2, thus leading to the accumulation of c-Myc expression. Additionally, c-Myc acted as a transcription factor that can induce the expression of BAALC-AS1 by directly binding to its promoter region. Yes In vivo and in vitro assays showed that BAALC-AS1 promoted ESCC cell proliferation, migration, and invasion. 33476486 B4GALT1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[B4GALT1-AS1/miR-30e/SOX9 axis ] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay An elevated B4GALT1-AS1 mRNA level was observed in NSCLC tissues compared with adjacent healthy tissues (Fig. 1A).The findings of the present study indicated that the B4GALT1-AS1/miR-30e/SOX9 axis maybe an effective target for NSCLC treatment and management. Yes The results of the present study demonstrated that knockdown of B4GALT1-AS1 significantly attenuated the proliferative ability and clonality of H1299 and A549 cells. 33014162 B4GALT1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines and tissues Interaction(miR-144-3p/ZEB1 ) CCK8//qRT-PCR We showed significant upregulation of B4GALT1-AS1 in cell lines and tissues of NSCLC. The demonstration of the binding capacity of B4GALT1-AS1 and miR-144-3p was predicted by bioinformatics and luciferase reporter activity assay. The B4GALT1-AS1 and miR-144-3p interaction was shown by using rescue experiments. NSCLC has a positive association with its target, zinc finger e-box binding homeobox 1 (ZEB1). Yes B4GALT1-AS1 knockdown impeded the in vitro proliferation-related characteristics of the NSCLC cells. 35402178 ATXN8OS LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines Interaction[sequestering miR‑204] qRT-PCR//Luciferase Report Assay It was found that ATXN8OS was markedly up‑regulated in BC tissue and cell lines, and that its level of overexpression was inversely linked with the overall survival rate of patients with BC. In conclusion, the present study suggested that ATXN8OS acts as a tumour promoter by sequestering miR‑204 during the development of BC, therefore providing a mechanistic insight which may facilitate the diagnosis and treatment of BC. It was found that ATXN8OS was markedly up‑regulated in BC tissue and cell lines, and that its level of overexpression was inversely linked with the overall survival rate of patients with BC. Yes Knockdown of ATXN8OS inhibited proliferation, viability and invasion in the human MCF7 and MDA‑MB‑231 BC cell lines. 31173245 ATXN7 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR The results revealed that circATXN7 was upregulated in 45 NSCLC tissues compared with its expression in non-tumor tissues. It was also observed that the survival time of patients with high circATXN7 levels was shorter compared with that of patients with low circATXN7 levels, although the difference was not statistically significant (P>0.05). Yes Furthermore, silencing of circATXN7 by small interfering RNA inhibited the proliferation and invasion of NSCLC cells in vitro. 31186686 Atxn2l-203 CircRNA Rattus norvegicus Neuralgia NP rat and cell models  Interaction(miR-216a-5p/TXNIP axis) Western Blot//ISH//Transfection//qPCR//Flow Cytometry//RIP//PCR//IP//ELISA//IF The results exposed that circSMEK1 and TXNIP were up-regulated in NP, while miR-216a-5p was down-regulated. The claw retraction threshold and claw retraction latency in rats were elevated and reduced separately via knockdown circSMEK1 and miR-216a-5p. Mechanism studies demonstrated that circSMEK1 mediated TXNIP expression through competitive adsorption of miR-216a-5p. Functional rescue experiments manifested that the suppressive effect of circSMEK1 knockdown on NP was reversed by declined miR-216a-5p simultaneously. Yes Meanwhile, knockout circSMEK1 or elevated miR-216a-5p declined inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL6 in spinal cord, and the activation of microglia, but promoted the polarization of microglia into anti-inflammatory type, while up-regulation of circSMEK1 or knockdown of miR-216a-5p was opposite. 34517790 ATP1A1-AS1 LncRNA Homo sapiens Thyroid Neoplasms THCA cells and tissues Interaction(miR-620/IRF2BP2 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//FISH//Luciferase Report Assay ATP1A1-AS1 was decreased in THCA cells and tissues. MiR-620, which was upregulated in THCA, was identified as a direct target of ATP1A1-AS1. Furthermore, IRF2BP2 was discovered to be a target of miR-620, which displayed low expression in THCA cells and tissues. Importantly, IRF2BP2 knockdown reversed the influence of ATP1A1-AS1 overexpression on THCA cell proliferation and apoptosis. Yes ATP1A1-AS1 overexpression attenuated cell growth and promoted apoptosis. 36002076 ASB16-AS1 LncRNA Homo sapiens Stomach Neoplasms GC samples Regulation(NF-kappa B (NF-κB) pathway ) In Vivo Experiment//RNA Pull-Down//Northern Blot//IHC//Western Blot//Co-IP//CCK8//qRT-PCR//FISH//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//IF ASB16-AS1 was upregulated in GC samples according to GEO data and qRT-PCR analysis.Mechanistically, ASB16-AS1 strengthened TRIM37 expression by sequestering miR-3918 and miR-4676-3p. ASB16-AS1 activated NF-kappa B (NF-κB) pathway by cooperating with ATM serine/threonine kinase (ATM) to induce TRIM37 phosphorylation. Yes ASB16-AS1 strengthened the proliferative ability and stem cell-like characteristics in GC cells. More importantly, ASB16-AS1 encouraged GC cell growth in vivo. 32572790 ASB16-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(miR-185-5p/TEAD1 axis) RNA Pull-Down//Western Blot//Tunel//RIP//qRT-PCR In our research, we discovered that ASB16-AS1 was with high expression in CRC cells. In addition, ASB16-AS1 silencing restrained the proliferation, migration, invasion, and stemness while accelerating cell apoptosis of CRC cells. Mechanism experiments were applied to explore the regulatory mechanism of ASB16-AS1. It turned out that miR-185-5p could interact with ASB16-AS1 and inhibited the progression of CRC cells. TEAD1 (TEA domain transcription factor1) - a major effector of the Hippo signaling was proved to serve as the target of miR-185-5p and promote CRC development. Yes In addition, ASB16-AS1 silencing restrained the proliferation, migration, invasion, and stemness while accelerating cell apoptosis of CRC cells. 34870557 ASB16-AS1 LncRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues Interaction(miR-1258) qRT-PCR//MTT The expression levels of ASB16-AS1 and miR-1258 in esophageal cancer tissues were 2.95±0.27 and 0.62±0.06, respectively. ASB16-AS1 targeted negative regulation of miR-1258 expression. Yes The cell viability of the si-NC group at 48 h and 72 h were 0.81±0.07 and 1.15±0.11, while those of si-ASB16-AS1 group were 0.46±0.04 and 0.62±0.06 (P<0.05). The numbers of cell migration and invasion in the si-NC group were 86.32±8.24 and 71.29±7.15, respectively, while those of si-ASB16-AS1 group were 43.22±4.31 and 32.36±3.58, respectively, the differences were statistically significant (P<0.05). The cell viability of the miR-NC group at 48 h and 72 h were 0.84±0.08, 1.18±0.12, while those of miR-1258 group were 0.55±0.05, 0.71±0.07 (P<0.05). The migration and invasion numbers of the miR-NC group were (83.15±8.31) and (75.33±7.51), while those of miR-1258 group were (49.58±4.23) and (38.42±3.84), respectively, the differences were statistically significant (P<0.05). The cell viability of the si-ASB16-AS1+ anti-miR-NC group at 48 h and 72 h were 0.45±0.04, 0.61±0.06, while those of si-ASB16-AS1+ anti-miR-1258 group were 0.72±0.07, 0.98±0.08; The migration and invasion numbers of cells in the si-ASB16-AS1+ anti-miR-NC group were 44.36±4.41 and 31.69±3.85, respectively, while those of si-ASB16-AS1+ anti-miR-1258 group were 72.65±7.27 and 61.22±6.14, respectively, and the differences were statistically significant (P<0.05). 34289570 ASB16-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and CC cells regulation[miR-1305/Wnt/β-catenin axis ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In our study, we showed that the expression of ASB16-AS1 was increased while miR-1305 reduced was re in CC.This study reveals that ASB16-AS1 promotes cell proliferation, migration, invasion via binding miR-1305 with Wnt2, and enhancing the Wnt/β-catenin pathway. ASB16-AS1 may play a new therapeutic target for CC. Clinically, ASB16-AS1 and miR-1305 were correlated with poor-associated clinicopathological features of CC patients. Yes Knockdown of ASB16-AS1 reduced CC cells proliferation, migration and invasion abilities by regulating miR-1305 in vitro and in vivo. 32058219 ASB16-AS1 LncRNA Homo sapiens Glioma Glioma tissues Expression[highly expressed] Flow Cytometry//qRT-PCR//Western Blot RT-qPCR was used to detect the expression of ASB16-AS1 in human glioma tissues. The results indicated that the expression of ASB16-AS1 was obviously increased in 77 glioma tissues in comparison with 15 normal tissues. Yes It was observed that the proliferation, invasion, and migration abilities of the cells were significantly suppressed upon knocking down ASB16-AS1 in U87GS and U251GS cells (Figure 4). 30949502 ASB16-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues interaction[miR-185-5p/miR-214-3p] RNA Pull-Down//Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay In this study, we found that the expression of the long noncoding RNA (lncRNA) ASB16-AS1 was downregulated in ccRCC tissues compared with non-diseased tissues and was also associated with advanced tumor stage and larger tumors.ASB16-AS1 promotes ccRCC progression via a miR-185-5p-miR-214-3p-LARP1 pathway. Yes By constructing cell and mouse models, it was found that downregulated lncRNA ASB16-AS1 enhanced cell proliferation, migration, invasion, and promoted tumor growth and metastasis. 33680937 ASB16-AS1 LncRNA Homo sapiens Adrenocortical Carcinoma adrenocortical carcinoma tissues regulation[HuR] RNA Pull-Down//ISH//Immunoblotting//CCK8//qRT-PCR//RIP//RNA-seq//Cell Cycle Assay//IHC//EdU Staining Here, we found that lncRNA ASB16-AS1 was down-regulated in adrenocortical carcinoma and ASB16-AS1 functions as tumor suppressor in vitro and in vivo. We then found that inhibition of ASB16-AS1 attenuates the binding of ubiquitin E3 ligase BTRC to HuR and subsequently inhibits HuR protein unbiquitination and degradation. BTRC knock-down could reverse the effect of AB16-AS1 on HuR, CDK6, and IGF1R levels. Yes Here, we found that lncRNA ASB16-AS1 was down-regulated in adrenocortical carcinoma and ASB16-AS1 functions as tumor suppressor in vitro and in vivo. 33219221 ASB16-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular tumor tissues Regulation cell invasion assay//Transfection//Migration Assay//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay In terms of comprehensive analysis, compared with non-tumor tissues, ASB16-AS1 was highly expressed in tumor tissues, and indicated the value of poor prognosis in multiple cancer types. Yes Functional assays, such as counting kit-8 assay, transwell assay and scratch-wound assay verified that high ASB16-AS1 expression promoted tumor progression in LIHC. 34709970 ASAP1‑IT1 LncRNA Homo sapiens Ovarian Neoplasms ovarian tumor samples and ovarian cancer cells Interaction(miR‑2278/LATS2) CCK8//qRT-PCR//Luciferase Report Assay//Western Blot The analysis indicated that lncRNA ASAP1‑IT1 expression was downregulated in ovarian tumor samples and ovarian cancer cells. Bioinformatics analysis predicted that miR‑2278, a previously reported upregulated miRNA in ovarian tumors, may bind to ASAP1‑IT1. Dual luciferase assay confirmed the direct regulatory association between ASAP1‑IT1 and miR‑2278. In addition, the data demonstrated that large tumor suppressor 2 (LATS2) was a target gene of miR‑2278, whose expression was upregulated by ASAP1‑IT1 in ovarian cancer cells. Yes The overexpression of ASAP1‑IT1 inhibited ovarian cancer cell proliferation and induced cell apoptosis.  33576454 ASAP1-IT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues, cancer cells and spheres of cancer stem cells Interaction(miR-509-3p/YAP1 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay knockdown of ASAP1-IT1 or overexpression of miR-509-3p repressed tumor growth in nude mice via reducing expression of tumorigenic genes. Yes knockdown of ASAP1-IT1 or overexpression of miR-509-3p repressed tumor growth in nude mice via reducing expression of tumorigenic genes. 34715859 ASAP1-IT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-221-3p) qRT-PCR ASAP1-IT1 levels were significantly increased in HCC tissues and cells compared with controls. Mechanistically, ASAP1-IT1 might exert its role in HCC progression, at least in part, by directly interacting with miR-221-3p. Notably, higher ASAP1-IT1 levels were significantly associated with poorer prognosis of HCC patients. Yes Furthermore, knockdown of ASAP1-IT1 significantly suppressed cell proliferation and migration, while its overexpression significantly promoted cell proliferation and migration of HCC cells. 35712508 ASAP1-IT1 LncRNA Homo sapiens Cholangiocarcinoma Cholangiocarcinoma tissues and cells Regulation( Smo and Gli1 ) Cell Proliferation Assay//qRT-PCR//migration assay//Western Blot The high expression level of ASAP1-IT1 was tested in Cholangiocarcinoma tissues and cells with qRT-PCR.As a results, the Cholangiocarcinoma progression was inhibited. Hedgehog signaling pathway has been discovered to be a treatment target in Cholangiocarcinoma. In this study, the interaction between ASAP1-IT1 and hedgehog pathway was specifically investigated. Smo and Gli1, two hedgehog-related proteins were examined in Cholangiocarcinoma cells. The results of qRT-PCR and western blot assay suggested that ASAP1-IT1 could positively modulate Smo and Gli1 in Cholangiocarcinoma. Finally, rescue assays were carried out to prove that ASAP1-IT1 could improve Cholangiocarcinoma progression and development via hedgehog signaling pathway. Upregulation of ASAP1-IT predicted the unfavorable prognosis for Cholangiocarcinoma patients. Yes Next, ASAP1-IT1 was knocked down in cancerous cells for loss-of function assay. MTT, colony formation and transwell and western bot assays were performed to demonstrate the specific impacts of ASAP1-IT1 on proliferation, migration and EMT progression of Cholangiocarcinoma. Cells. 29653361 AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cells and prostate cancer cells (PCCs) Expression(highly expressed) Cell Cycle Assay//qPCR//Transwell Assay//Western Blot LncRNA NCK1-AS1 is highly expressed in PCa, so its down-regulation can inhibit PCCs from proliferating and reduce the number of invasive cells. The prognosis of patients with high LncRNA NCK1-AS1 expression was remarkably poorer than that of those with low expression. Yes Compared with the Blank group, cell proliferation and the number of plate cloned cells remarkably reduced in the sh-NCK1-AS1 group. 34151833 ARRDC1-AS1 LncRNA Homo sapiens Glioma glioma specimens and cell lines regulation[miR-432-5p/PRMT5 axis ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay In this study, we firstly reported that ARRDC1-AS1 expression was distinctly increased in both glioma specimens and cell lines, and high ARRDC1-AS1 expression was associated with advanced clinical progression and poor prognosis of glioma patients.Overall, our findings highlighted the importance of STAT1/ARRDC1-AS1/miR-432-5p/PRMT5 axis in glioma progression and offered novel strategies for glioma treatments. In this study, we firstly reported that ARRDC1-AS1 expression was distinctly increased in both glioma specimens and cell lines, and high ARRDC1-AS1 expression was associated with advanced clinical progression and poor prognosis of glioma patients. Yes Functional studies revealed that knockdown of ARRDC1-AS1 suppressed the proliferation, migration and invasion of glioma cells. 33220929 ARRDC1-AS1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues and cell lines Interaction(miR-2355-5p to regulate ATG5) Western Blot//Flow Cytometry//qRT-PCR//Colony Formation Assay//Transwell Assay We found that ARRDC1-AS1 was upregulated in DLBCL tissues and cell lines. ARRDC1-AS1 was activated by transcription factor PAX5. Yes Knockdown of ARRDC1-AS1 suppressed DLBCL autophagy to aggravate proliferation, repress apoptosis, and facilitate invasion and migration. Furthermore, ARRDC1-AS1 sponged miR-2355-5p to upregulate ATG5. 34499929 ARHGEF26-AS1 LncRNA Homo sapiens Esophageal Neoplasms EC patients Interaction(miR-372-3p) qRT-PCR//Luciferase Report Assay The findings revealed that low expression of ADAM23 and ARHGEF26-AS1 as well as high expression of miR-372-3p was associated with poor prognosis and a lower FPI score in EC patients. Mechanistically, ARHGEF26-AS1 upregulated the expression of ADAM23 by competitively binding to miR-372-3p. The findings revealed that low expression of ADAM23 and ARHGEF26-AS1 as well as high expression of miR-372-3p was associated with poor prognosis and a lower FPI score in EC patients. Yes Functionally, overexpression of ADAM23 and ARHGEF26-AS1 and the miR-372-3p inhibitor not only promoted ferroptosis in ESCC cells in vitro but also inhibited the proliferation and migration of cells. 35003396 ARHGAP5-AS1 LncRNA Homo sapiens Breast Neoplasms cell lines Interaction(SMAD7) RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//FISH//IF//RIP//Luciferase Report Assay//Transwell Assay We analyzed the RNA-seq data of MDA-MB-231 and its highly metastatic derivative MDA-MB-231-LM2 cell lines (referred to as LM2) and identified a novel lncRNA (NR_027263) named as ARHGAP5-AS1, which expression was significantly downregulated in LM2 cells. Afterwards, SMAD7 was further identified to interact with ARHGAP5-AS1 by its PY motif and thus its ubiquitination and degradation was blocked due to reduced interaction with E3 ligase SMURF1 and SMURF2. Yes Further functional investigation showed ARHGAP5-AS1 could inhibit cell migration via suppression of stress fibers in breast cancer cell lines. 34370213 ASMTL-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cells Regulation(U2AF2/SAT1 ) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//IF//Colony Formation Assay//Transwell Assay Results showed that ASMTL-AS1 was down-regulated in LUAD cells and ASMTL-AS1 up-regulation resulted in retarded LUAD cell and xenograft tumor growth along with stimulated ferroptosis. ASMTL-AS1 recruited U2AF2 to stabilize SAT1 mRNA. Furthermore, SAT1 exerted a cancer suppressor role in LUAD cells. In conclusion, we first demonstrated that ASMTL-AS1 positively regulated SAT1 to promote ferroptosis and could stabilize SAT1 mRNA via recruiting U2AF2, shedding a light on a novel molecular mechanism in LUAD progression. Yes Results showed that ASMTL-AS1 was down-regulated in LUAD cells and ASMTL-AS1 up-regulation resulted in retarded LUAD cell and xenograft tumor growth along with stimulated ferroptosis. 34658100 ASMTL-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Interaction(miR-1228-3p/SOX17/β-catenin axis ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay ASMTL-AS1 was significantly downregulated in TNBC tissues compared to normal tissues, which was closely associated with aggressive clinical features and unfavorable prognosis. RNA pull-down and luciferase reporter assays revealed that miR-1228-3p directly bound to ASMTL-AS1, ASMTL-AS1 increased SOX17 expression via sponging and repressing miR-1228-3p. Subsequently, the upregulated SOX17 trans-suppressed β-catenin expression, resulting in the inactivation of carcinogenic Wnt/β-catenin signaling, thereby restraining TNBC cell growth and dissemination. Yes Lentivirus-mediated ASMTL-AS1 overexpression evidently reduced the ability of TNBC cell colony formation, activity and invasion by more than 2.5 times. 34006305 ASMTL-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues Interaction(miR-342-3p/ADAM9 axis.) CCK8//qRT-PCR ASMTL-AS1 expression in OS was elevated in both TCGA database and our own cohort. Mechanistically, ASMTL-AS1 could act as a competing endogenous RNA for microRNA-342-3p (miR-342-3p) and inhibit its activity in OS cells, consequently causing an increase in ADAM metallopeptidase domain 9 (ADAM9) levels. Furthermore, inhibiting miR-342-3p or upregulating ADAM9 abated silenced ASMTL-AS1-induced antitumour activity in OS cells. Yes Interfering with ASMTL-AS1 restricted cell proliferation, migration and invasion while increasing cell apoptosis in vitro. Additionally, silencing ASMTL-AS1 blocked tumour growth in vivo. 34597997 ATB LncRNA Homo sapiens Ovarian Neoplasms OC tissues Interaction(EZH2) RNA Pull-Down//Western Blot//qRT-PCR//RIP//IHC//ChIP n our research, lnc-ATB expression in OC tissues was elevated compared with adjacent normal tissues and high expression of lnc-ATB was associated with poor outcomes of OC patients. RNA immunoprecipitation and RNA pull-down results showed that lnc-ATB positively regulated the expression of EZH2 via directly interacting with EZH2. n our research, lnc-ATB expression in OC tissues was elevated compared with adjacent normal tissues and high expression of lnc-ATB was associated with poor outcomes of OC patients. Yes The silencing of lnc-ATB blocked cell proliferation, invasion and migration in SKOV3 and A2780 cells. 33336896 ATB LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction[increasing miR-141-3p] qRT-PCR//Western Blot Here, we found that lnc-ATB was highly expressed, whereas there was low expression of miR-141-3p in breast cancer tissues and cells. Knockdown of lnc-ATB in two breast cancer cell lines (MDA-MB-231 and BT549) significantly increased miR-141-3p expression. Down-regulation of lnc-ATB resulted in a morphological change of breast cancer cells from spindle-like to a round shape, and in a remarkable inhibition of cell migration and invasion, which were reversed by miR-141-3p inhibitor. Furthermore, we demonstrated that lnc-ATB knockdown decreased ZEB1, ZEB2, N-cadherin, and vimentin expression, and promoted E-cadherin expression, while miR-141-3p inhibitor could reverse those effects. Moreover, we proved that miR-141-3p directly bound to the 3' untranslated region (UTR) of ZEB1 and ZEB2 and negatively regulated ZEB1 and ZEB2 expression. Taken together, our results show that knockdown of lnc-ATB significantly inhibits the EMT process of breast cancer cells by increasing the expression of miR-141-3p, indicating that lnc-ATB might serve as a novel therapeutic target for breast cancer. Yes Down-regulation of lnc-ATB resulted in a morphological change of breast cancer cells from spindle-like to a round shape, and in a remarkable inhibition of cell migration and invasion, which were reversed by miR-141-3p inhibitor. 30352165 ATB LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[suppressing miR-141-3p] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay In this study, lncRNA-ATB was significantly up-regulated in NSCLC tissues and cell lines, and high lncRNA-ATB expression indicated poor prognosis.Further mechanism studies demonstrated that lncRNA-ATB was a target of miR-141-3p. MiR-141-3p expression was negatively related to lncRNA-ATB expression in NSCLC tissues. In this study, lncRNA-ATB was significantly up-regulated in NSCLC tissues and cell lines, and high lncRNA-ATB expression indicated poor prognosis. Yes Knockdown of lncRNA-ATB suppressed NSCLC cell growth, colony formation, migration, invasion and reversed epithelial-mesenchymal transition. In vivo study showed that silencing lncRNA-ATB inhibited tumor growth. 32092085 ATB LncRNA Homo sapiens Colorectal Neoplasms CRC tissues ,cell lines interaction[ sponging miR-141-3p] IHC//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay lncRNA-ATB was upregulated in CRC tissues and cell lines compared with healthy tissues and cells, respectively. Moreover, high expression of lncRNA-ATB was significantly associated with advanced TNM stage and metastasis in CRC. In addition, the results indicated that lncRNA-ATB expression predicted the prognosis and overall survival of patients with CRC. Yes Compared with small interfering RNA-negative control, lncRNA-ATB knockdown inhibited CRC cell proliferation, migration and invasion, whereas, compared with vector, lncRNA-ATB overexpression promoted CRC cell proliferation, migration and invasion. Furthermore, the in vivo experiment suggested that lncRNA-ATB knockdown inhibited tumor growth. 33199986 ATB LncRNA Homo sapiens Thyroid Cancer, Papillary tumor tissues interaction[TGF-β1] qRT-PCR//Western Blot//Transwell Assay lncRNA-ATB expression level was higher in tumor tissues than in adjacent healthy tissues in most PTC patients.Upregulation of lncRNA-ATB by TGF-b1 promotes migration and invasion of PTC cells. Yes lncRNA-ATB overexpression promoted tumor cell migration and invasion, lncRNA-ATB overexpression showed no significant effects on TGF-β1 expression, and TGF-β1 treatment increased the expression level of lncRNA-ATB. 30042377 ATB LncRNA Homo sapiens Carcinoma, Renal Cell Interaction[downregulating p53 via binding to DNMT1] IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//EdU Staining//Transwell Assay Our previous study found that lncRNA ATB was highly expressed in renal cell carcinoma (RCC). To sum up, our study revealed that high expression of lncRNA ATB could accelerate the proliferative and migratory rates of RCC cells and inhibit cell apoptosis through downregulating p53 via binding to DNMT1. Yes The results showed that lncRNA ATB knockdown in RCC cell line ACHN inhibited proliferative and migratory capacities and promoted apoptosis. 30536843 ATB LncRNA Homo sapiens Osteoarthritis cell line( ATDC5) Interaction[microRNA-5] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//ELISA Additionally, we observed that lncRNA-ATB expression was Expression[down-expression]-regulated in LPS-injured cells, and lncRNA-ATB overexpression significantly alleviated LPS-induced inflammatory injury in ATDC5 cells. Yes Additionally, we observed that lncRNA-ATB expression was Expression[down-expression]-regulated in LPS-injured cells, and lncRNA-ATB overexpression significantly alleviated LPS-induced inflammatory injury in ATDC5 cells. 30771739 ATB LncRNA Homo sapiens Ovarian Neoplasms cell line(SKOV3) Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay The results indicated that lncRNA-ATB was expressed at significantly higher levels in SKOV3 cells compared with the healthy cell line. Yes LncRNA-ATB downregulation significantly reduced SKOV3 cell proliferation, invasion and migration, promoted apoptosis, decreased the expression of p-STAT3 and vimentin, and increased E-cadherin expression. 32010258 ATB LncRNA Homo sapiens Ovarian Neoplasms tissues or cells interaction[Targeting miR-204-3p] RNA Pull-Down//Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay//Transwell Assay In addition, luciferase activity suggested that lncRNA-ATB negatively regulated miR-204-3p in ovarian cancer. Besides, Nidogen 1 (NID1) was the direct target of miR-204-3p. Yes LncRNA-ATB silencing significantly inhibited the proliferation and induced apoptosis of ovarian cancer cells. 32021299 ATB LncRNA Homo sapiens Ovarian Neoplasms HUVECs Interaction(miR-204-3p/TGFβR2 Axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Ovarian cancer cells-derived exosomes promoted the viability, angiogenesis and migration of HUVECs; however, knockdown of lncRNA ATB in HUVECs reversed these phenomena. In addition, exosomal lncRNA ATB promoted the tumorigenesis of ovarian cancer via regulating miR-204-3p/TGFβR2 axis. Furthermore, ovarian cancer cells-secreted exosomal lncRNA ATB increased tumor growth in vivo. Yes Ovarian cancer cells-derived exosomes promoted the viability, angiogenesis and migration of HUVECs; however, knockdown of lncRNA ATB in HUVECs reversed these phenomena. Furthermore, ovarian cancer cells-secreted exosomal lncRNA ATB increased tumor growth in vivo. 35115831 ASMTL-AS1 LncRNA Homo sapiens Ovarian Neoplasms tumorous tissues and cell lines Interaction(miR-1228-3p) qRT-PCR In tumorous tissues and cell lines, ASMTL-AS1 was lowly expressed compared with normal ones. ASMTL-AS1 overexpression strongly decreased cell proliferation, migration, and invasion in vitro partly by moderating miR-1228-3p. This downregulation was associated with the advanced FIGO stage, positive ascites cytology, and lymph node. In particular, low levels of ASMTL-AS1 were revealed to have a high prognostic impact on EOC. Yes ASMTL-AS1 overexpression strongly decreased cell proliferation, migration, and invasion in vitro partly by moderating miR-1228-3p. 35835145 ATB LncRNA Homo sapiens Cholangiocarcinoma CCA tissues Interaction[miR-200c signals] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot CCA tissues have increased Lnc-ATB and reduced miR-200a/b/c levels, but the down-regulated miR-200c was most prominent. Overexpressed Lnc-ATB functioned as an oncogene for CCA growth and metastasis via miR-200 signals. Yes Inhibition of Lnc-ATB significantly impaired cell vitality and induced apoptosis and G0/G1 arrest, which, however, was rescued by miR-200c inhibitor. 31571907 ATB LncRNA Homo sapiens Melanoma MM tissues and cells interaction[miR-590-5p] qRT-PCR In the present study, it was identified that lncRNA activated by transforming growth factor?β (lncRNA?ATB) was upregulated in MM tissues and cells compared with benign nevus cells and human melanocytes, via comparative lncRNA screening from Gene Expression Omnibus datasets and reverse transcription?quantitative polymerase chain reaction analysis. Yes Furthermore, lncRNA?ATB promoted the cell proliferation, cell migration, and cell invasion of MM cells in vitro, and tumor growth in vivo. 29956757 ATB LncRNA Homo sapiens lung squamous cell carcinoma LSC tissues and cell lines regulation[microRNA-590-5p/NF90 Axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//IF//Colony Formation Assay//Transwell Assay In our study, lncRNA-ATB expression also markedly increases in LSC tissues and cell lines in comparison to the adjacent normal tissues and normal lung epithelial cells, respectively.Taken together, our initial data suggest that lncRNA-ATB overexpression may promote the progression of LSC by modulating the microRNA-590-5p/NF-90 axis. Yes Functional experiments indicate that lncRNA-ATB overexpression improves the proliferative, migratory, and invasive capabilities of normal lung epithelial cells compared with control group. 31934791 ATAD1 CircRNA Homo sapiens Leukemia, Myeloid, Acute patients with AML Interaction(miR-34b) BrdU//qRT-PCR circ-ATAD1 expression was found to be elevated, and inversely correlated with that of miR-34b, in patients with AML. In addition, circ-ATAD1 overexpression in AML cells decreased miR-34b expression and increased miR-34b gene methylation. Yes Moreover, AML cell proliferation was increased by circ-ATAD1 overexpression, but decreased by miR-34b overexpression, and the effect of circ-ATAD1 overexpression on AML cell proliferation was reduced by miR-34b overexpression. 34630706 ASNR LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues Interaction(miR-519e-5p/FGFR2) In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Invasion Assay High expressed Lnc_ASNR was detected in both GC cells and tissues using qRT-PCR. The bioinformatics analysis, luciferase assay, and Western blot demonstrated that Lnc_ASNR inhibited miR-519e-5p expression but increased FGFR2 expression. Lnc_ASNR and FGFR2 were both targeted to miR-519e-5p, and they were negatively correlated with the expression of miR-519e-5p. Yes Downregulated Lnc_ASNR could reduce proliferation, migration, and invasion in GC cells, while upregulated Lnc_ASNR could promote the cell proliferation, migration, and invasion. Moreover, the effect of Lnc_ASNR on migration and invasion ability is closely related to epithelial-mesenchymal transition (EMT). 34307360 ASMTL-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cell lines Interaction(ASMTL-AS1/microRNA-1270 ) RNA Pull-Down//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay ASMTL-AS1 was significantly downregulated while miR-1270 was upregulated in gastric cancer tissues as compared with normal tissue and cell lines.In summary, ASMTL-AS1 and miR-1270 are associated with poor prognosis of patients with gastric cancer. ASMTL-AS1 inhibited gastric cancer progression by regulating miR-1270. According to the studies, ASMTL-AS1 and miR-1270 were related to unfavorable clinical parameters, such as the advanced TNM stage. Downregulated ASMTL-AS1 and upregulated miR-1270 were associated with reduced 5-year overall survival. Yes Functional studies suggested that ASMTL-AS1 inhibits proliferation, migration, and invasion of HGC-27 and NCI-N87 cells by regulation of miR-1270. 34986743 ASMTL-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissue regulation[miR-93-3p/miR-660/FOXO1 axis ] qRT-PCR In the current study, we found that a novel lncRNA, ASMTL antisense RNA 1 (ASMTL-AS1), was significantly downregulated in PTC.Collectively, our data clearly indicate that ASMTL-AS1 functions as a novel tumor suppressor in PTC through regulation of miR-93-3p/miR-660/FOXO1 pathway. And its downregulation was positively linked to larger tumor size, advanced clinical stage and unfavorable outcome. Yes Overexpression of ASMTL-AS1 evidently inhibited PTC cell proliferation and glycolysis, while knockdown of ASMTL-AS1 resulted in the opposite effect. 31953163 ASMTL-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells, Interaction(miR-1343-3p/LAMC1 axis) qRT-PCR ASMTL-AS1 and LAMC1 were highly expressed in HCC tissues and cells, whereas miR-1343-3p showed low expression. Clinically, miR-1343-3p expression in HCC tissues showed a negative correlation with ASMTL-AS1 or LAMC1 expression. More interestingly, ASMTL-AS1 sponged miR-1343-3p and miR-1343-3p to target the 3'-UTR of LAMC1, thereby interfering with the malignant behavior of HCC cells. In conclusion, ASMTL-AS1 acts as a carcinogen in HCC through competing endogenous RNA (ceRNA) activity in the miR-1343-3p/LAMC1 axis. Yes Functional assays demonstrated that ASMTL-AS1 silencing suppressed HCC cell proliferation and migration and increased cell apoptosis. 34859735 BANCR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cell lines Expression [highly expressed] qRT-PCR//MTT//Western Blot The results revealed that lncRNA BANCR was highly expressed in ESCC cells compared with in normal esophageal cells. Yes BANCR overexpression enhanced proliferation, migration and invasion of ESCC cells, and BANCR silencing exerted opposite effects. Moreover, BANCR overexpression induced activation of the Raf/MEK/ERK signaling pathway in ESCC cells. 33880577 BANCR LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Expression(highly expressed) Western Blot//Migration Assay//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay The expression level of lncRNA BANCR in breast cancer tissues was significantly higher than that in para-carcinoma normal tissues. Results of Western blotting revealed that the expressions of B-cell lymphoma 2 associated X protein (BAX), cleaved-Caspase-3 and cleaved-poly adenosine diphosphate-ribose polymerase (PARP) in knockdown group were significantly up-regulated compared with those in control group. Both wound-healing assay and transwell migration assay showed that the down-regulation of lncRNA BANCR could inhibit the invasion and metastasis capacities of MCF-7 cells, whose mechanism was related to the inhibition of EMT process and down-regulation of MMP expressions in cells. The prognosis of patients in low-expression BANCR group was significantly superior to that of patients in high-expression BANCR group. Yes After BANCR knockdown in breast cancer MCF-7 cells, the cell proliferation and colony formation capacities were significantly inhibited. Further mechanism research showed that inhibiting BANCR could promote the apoptosis of MCF-7 cells. 29565494 BMPR1B-DT LncRNA Homo sapiens Endometrial Neoplasms EC cells Interaction(miR-7-2-3p/DCLK1 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//IHC//Transwell Assay In this study, we analyzed the RNA transcripts of EC cells from The Cancer Genome Atlas (TCGA) and first reported a novel lncRNA, BMPR1B-AS1, that was more highly expressed in endometrial cancer tissues than in adjacent tissues, and BMPR1B-AS1 could promote endometrial cancer cell proliferation and metastasis. Bioinformatics prediction and experimental results both suggested that BMPR1B-AS1 could modulate the malignant behaviors of endometrial cancer cell lines by sponging miR-7-2-3p to modulate DCLK1, and a DCLK1 inhibitor blocked the activation of the PI3K/Akt/NF-κB signaling pathway. Yes Bioinformatics prediction and experimental results both suggested that BMPR1B-AS1 could modulate the malignant behaviors of endometrial cancer cell lines by sponging miR-7-2-3p to modulate DCLK1, and a DCLK1 inhibitor blocked the activation of the PI3K/Akt/NF-κB signaling pathway. 35404759 BISPR LncRNA Homo sapiens Thyroid Cancer, Papillary TPC tissues Regulation[miR-21-5p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay BISPR in TPC tissues was over-expressed. BISPR stimulated propagation and invasiveness of TPC cells by depressing miR-21-5p. Yes BISPR knockdown restrained the propagation and invasiveness and enhanced the iodine uptake of TPC cells. The tumor-forming rate reduced after BISPR knockdown. 29856242 BICDL3P LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction[miR-1254-WNT11 pathway] qRT-PCR In the study, we found that ABHD11-AS1 was highly expressed in CRC tissues and cell lines. Investigation of the underlying mechanism showed that ABHD11-AS1 could act as a molecular sponge of miR-1254, and WNT11 was a downstream target of miR-1254 in CRC. Moreover, there was a negative association between ABHD11-AS1 expression (or WNT11) and miR-1254 in CRC tissues. The rescue assays showed that WNT11 overexpression partially rescued the effects of ABHD11-AS1 inhibition on CRC progression. High ABHD11-AS1 expression was correlated with poor overall survival of patients with CRC. Yes High ABHD11-AS1 expression was correlated with poor overall survival of patients with CRC. 30537177 BICDL3P LncRNA Homo sapiens Colorectal Neoplasms CRC and normal tissues Interaction( ITGA5/Fak/PI3K/Akt signaling pathway) CCK8//qRT-PCR//Western Blot In the present study, public database analysis and quantitative reverse transcription PCR of CRC and normal tissues showed that ABHD11-AS1 was overexpressed in CRC and associated with poor prognosis in CRC patients. Taken together, our studies suggest that lncRNA ABHD11-AS1 promotes proliferation, migration, and invasion in CRC by activating the ITGA5/Fak/PI3K/Akt signaling pathway, and that the ITGA5/Fak/PI3K/Akt axis is a promising target for CRC therapy. Yes Additionally, we noted that ABHD11-AS1 deficiency reduced integrin subunit alpha (ITGA)5 expression, and impaired the phosphorylation of P85, focal adhesion kinase (FAK), and Akt1 in CRC cell lines and tumor tissues of nude mice. Furthermore, we observed that ITGA5 overexpression abrogated the effect of ABHD11-AS1 knockdown on the proliferation and invasion abilities of CRC cells. 34375304 BICDL3P LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines Regulation[ PI3K/AKT signalling pathway and miR-1301-3p/STAT3 axis] Other High expression of ABHD11-AS1 predicted poor prognosis for patients with PTC and promoted cell proliferation and metastasis in vitro and in vivo. STAT3-induced lncRNA ABHD11-AS1 promoted PTC progression by regulating PI3K/AKT signalling pathway and miR-1301-3p/STAT3 axis. High expression of ABHD11-AS1 predicted poor prognosis for patients with PTC and promoted cell proliferation and metastasis in vitro and in vivo. Yes High expression of ABHD11-AS1 predicted poor prognosis for patients with PTC and promoted cell proliferation and metastasis in vitro and in vivo. 30657221 BICDL3P LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Regulation(EPS15L1/EGFR signaling pathway) qRT-PCR//MTT//Western Blot High expression of ABHD11-AS1 was found in PTC tissues (P < 0.01), which was significantly correlated with lymph node metastasis (P < 0.05). ABHD11-AS1 positively regulated EGFR/EPS15L1 pathway, as EGFR, EPS15L1, STAT3, and p-STAT3 were activated. Yes ABHD11-AS1 overexpression noticeably promoted cell proliferation, migration, and invasion capabilities, which were obviously decreased upon ABHD11-AS1 knockdown. 35098448 BICDL3P LncRNA Homo sapiens Ovarian Neoplasms EOC tissues and cell lines Interaction[suppressing TIMP2] qRT-PCR//Wound Healing Assay//Colony Formation Assay//Transwell Assay EGFR and ABHD11-AS1 were highly expressed in EOC tissues and cell lines.We defined the regulatory relationship between the EGFR signaling pathway, ABHD11-AS1, EZH2, and TIMP2 suggesting that ABHD11-AS1 may act as an oncogene and a potential target for antitumor therapies in ovarian cancer. Yes Knockdown of EGFR or ABHD11-AS1 inhibited cell growth, migration, and invasion of EOC cells. 31568657 BICDL3P LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer samples Interaction(EZH2/ABHD11-AS1/miR-133a-3p axis ) qRT-PCR//Transwell Assay The expression of ABHD11-AS1 was significantly upregulated in ovarian cancer samples, and its levels were closely associated with lymph node metastasis, tumor stage and 3-year survival rate. In summary, EZH2-mediated enrichment of H3K27me3 on ABHD11-AS1 promoter could regulate the progression of ovarian cancer via miR-133a-3p. The expression of ABHD11-AS1 was significantly upregulated in ovarian cancer samples, and its levels were closely associated with lymph node metastasis, tumor stage and 3-year survival rate. Yes Furthermore, interference of ABHD11-AS1 suppressed the proliferation, migration and invasion of ovarian cancer cells, while cell apoptosis was promoted 33491971 BICDL3P LncRNA Homo sapiens Endometrial Neoplasms endometrial tissue interaction[cyclin D1] qRT-PCR//RNA Pull-Down lncRNA ABHD11-AS1 was significantly overexpressed in endometrial carcinoma. LncRNA ABHD11-AS1 functions as an oncogene to promote cell proliferation and invasion in endometrial carcinoma by positively targeting cyclin D1. Yes Overexpression of lncRNA ABHD11-AS1 promoted the proliferation, G1-S progression, invasion and migration of endometrial cancer cells; inhibited apoptosis; up-regulated cyclin D1, CDK1, CDK2, CDK4, Bcl-xl and VEGFA; and down-regulated p16, while ABHD11-AS1 down-regulation has the opposite effect. 29799152 BICDL3P LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells Interaction(miR-330-5p/MARK2 axis) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//ISH//Transfection//Tunel//qRT-PCR//FISH//RIP//Luciferase Report Assay//H&E Staining//Colony Formation Assay//EdU Staining//Transwell Assay ABHD11-AS1 expression was abnormally high in CC cells. Moreover, miR-330-5p was corroborated to bind with ABHD11-AS1 in CC cells and microtubule affinity regulating kinase 2 (MARK2) was confirmed to be targeted by miR-330-5p. Yes In vitro experiments showed ABHD11-AS1 downregulation restrained CC cell malignant phenotypes. In vivo experiments proved ABHD11-AS1 knockdown impeded tumor growth. 34793775 BICDL3P LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues,cell lines Regulation[miR-199a-5p/SLC1A5 axis] qRT-PCR We found that ABHD11-AS1 was remarkably overexpressed in PTC, and high expression was related to tumor size, lymph node metastasis, extrathyroidal extension and advanced TNM stage. Taken together, the data show that ABHD11-AS1 acts as a competing endogenous RNA (ceRNA) to exert malignant properties in PTC through the miR-199a-5p/SLC1A5 axis. We found that ABHD11-AS1 was remarkably overexpressed in PTC, and high expression was related to tumor size, lymph node metastasis, extrathyroidal extension and advanced TNM stage. Yes Moreover, ABHD11-AS1 enhanced the abilities of cell proliferation, migration, and invasion, inhibited apoptosis in vitro, promoted tumorigenesis in vivo via sponging miR-199a-5p and then induced SLC1A5 activation. 31409775 BICDL3P LncRNA Homo sapiens Pancreatic Neoplasms interaction[Sponging miR-1231] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay To explore the gene expression data of pancreatic cancer and adjacent normal tissue, TCGA data were used. As indicated in Figure 1A, the expression of ABHD11-AS1 in pancreatic cancer tissues was significantly upregulated, compared with adjacent normal tissues. In addition, high expression of ABHD11-AS1 was negatively correlated with the survival rate of patients with pancreatic cancer (Figure 1B). Meanwhile, ABHD11-AS1 bound to miR-1231 and cyclin E1 was found to be the target of miR-1231. Moreover, ABHD11-AS1 knockdown-induced G1 arrest in pancreatic cancer cells was reversed by miR-1231 antagomir. ABHD11-AS1 was found to be negatively correlated with the survival rate of patients with pancreatic cancer. Yes ABHD11-AS1 silencing significantly inhibited the proliferation and induced the apoptosis of pancreatic cancer cells. Additionally, knockdown of ABHD11-AS1 greatly inhibited the migration and invasion of pancreatic cancer cells. Finally, knockdown of ABHD11-AS1 obviously inhibited the tumor growth of pancreatic cancer in vivo. 33177842 BICDL3P LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue specimens and cells Expression[highly expressed] qRT-PCR//MeRIP Here, lncRNA ABHD11-AS1 was upregulated in NSCLC tissue specimens and cells and the ectopic overexpression was closely correlated with unfavorable prognosis of NSCLC patients. Here, lncRNA ABHD11-AS1 was upregulated in NSCLC tissue specimens and cells and the ectopic overexpression was closely correlated with unfavorable prognosis of NSCLC patients. Yes Functionally, ABHD11-AS1 promoted the proliferation and Warburg effect of NSCLC. 32892348 BICDL3P LncRNA Homo sapiens Uterine Cervical Neoplasms serum and carcinoma tissues of cervical carcinoma patients, cells Interaction(miR-1254) Transfection//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay ABHD11-AS1 was upregulated, and miR-1254 was reduced in serum and carcinoma tissues of cervical carcinoma patients (P < 0.05). The expression levels of the two were negatively correlated (P < 0.001). ENCORI online website found that LncRNA ABHD11-AS1 and miR-1254 had binding sites. Bifluorescein reporter enzyme experiment found that ABHD11-AS1-WT fluorescence activity was inhibited by transfected miR-1254-mimics (P < 0.05). LncRNA ABHD11-AS1 accelerates proliferation, invasion, and migration of cervical carcinoma cells through targeted regulation of miR-1254, which may become the key to the treatment of cervical carcinoma. High ABHD11-AS1 and low miR-1254 had a close correlation with the poor prognosis of cervical carcinoma patients (P < 0.05). Yes Silencing LncRNA ABHD11-AS1 could inhibit the activity of cervical carcinoma cells (P < 0.05), while inhibiting miR-1254 could promote the activity of cervical carcinoma cells (P < 0.05). 35186240 BGLT3 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Regulation(PTEN stability) qRT-PCR//Wound Healing Assay//Co-IP//Western Blot BGL3 was significantly decreased in PTC tissues compared to adjacent normal thyroid tissues, and it was transcriptionally repressed by oncogene Myc. BGL3 was mainly located in the cytoplasm, in which interacted with PTEN and recruited OTUD3, enhancing the de-ubiquitination effect of OTUD3 on PTEN, resulting in increasing PTEN protein stability and inactivating carcinogenic PI3K/AKT signaling. Low BGL3 is positively related to larger tumor size, lymph node metastasis, later TNM stage and poor prognosis. Yes Overexpression of BGL3 inhibited PTC cell proliferation and migration in vitro, and reduced tumor size and lung metastasis nodules in vivo. 33543443 BG981369 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell line Interaction(SOX4 ) Migration Assay//qRT-PCR//MTT//Cell Cycle Assay//Colony Formation Assay//Invasion Assay The results indicated that lncRNA BG981369 was significantly higher in GC tissues than in normal tissues. Furthermore, we found that SOX4 may act as a downstream mediator of BG981369, suggesting that BG981369 inhibits proliferation, migration, and invasion, and promotes apoptosis by targeting SOX4 in the GC cell lines. Yes Overexpression of BG981369 inhibited the proliferation, migration, and invasion and promoted apoptosis of gastric adenocarcinoma (AGS) cells, and silencing of BG981369 promoted proliferation, migration, and invasion, and inhibited cell apoptosis of SNU-5 cells. 29398692 BE503655 LncRNA Homo sapiens Osteosarcoma cell lines Regulation[Wnt/β-catenin pathway] qRT-PCR//Western Blot//Transwell Assay LncRNA BE503655 is overexpressed in human osteosarcoma and osteosarcoma cell lines.Moreover, we also provided evidences that lncRNA BE503655 played its functions dependent on regulation of Wnt/β-catenin signaling in osteosarcoma. Yes Knockdown lncRNA BE503655 suppresses cell proliferation, invasion and migration. 31316000 BDNF-AS LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction[repressing GSK-3β] qRT-PCR//ChIP//RIP//Transwell Assay LncRNA BDNF-AS expression was significantly decreased, while GSK-3β was highly expressed in human CRC tissues and cell lines. Mechanistically, BDNF-AS led to GSK-3β promoter silencing in CRC cells through recruitment of EZH2. In conclusion, lncRNA BDNF-AS functioned as an oncogene in CRC and shed new light on lncRNA-directed therapeutics in CRC. Yes Moreover, lncRNA BDNF-AS induced inhibition of proliferation, migration, and invasion of CRC cells via inhibiting GSK-3β expression. 31062382 BDNF-AS LncRNA Homo sapiens Glioblastoma glioblastoma tissues and cells regulation[PABPC1-BDNF-AS-RAX2-DLG5] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Cell Apoptosis Assay//ChIP In this study, we confirmed that lncRNA brain-derived neurotrophic factor antisense (BDNF-AS) was downregulated in glioblastoma tissues and cells, interacted and stabilized by polyadenylate-binding protein cytoplasmic 1 (PABPC1). In general, this study elucidated that the PABPC1-BDNF-AS-RAX2-DLG5 mechanism may contribute to the anticancer potential of glioma cells and may provide potential therapeutic targets for human glioma. Yes Overexpression of BDNF-AS inhibited the proliferation, migration, and invasion, as well as induced the apoptosis of glioblastoma cells. 32015336 BDNF-AS LncRNA Homo sapiens Multiple Myeloma MM serum and corresponding cancer cell lines Interaction(miR-125a/b-5p-BCL2 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//EdU Staining BDNF-AS was significantly upregulated, while miR-125a-5p and miR-125b-5p were downregulated in MM serum and corresponding cancer cell lines. Knockdown of BDNF-AS effectively inhibited the proliferation and migration of MM.1S and U266 cells, and co-transfection of miR-125a-5p or miR-125b-5p inhibitor and sh-BDNF-AS enhanced cell proliferation and migration compared with that in sh-BDNF-AS group. Knockdown of miR-125a-5p or miR-125b-5p significantly enhanced the proliferation and migration of MM.1S and U266 cells, and co-transfection of sh-Bcl-2 and miR-125a/b-5p inhibitor inhibited cell proliferation compared with that in miR-125a/b-5p inhibitor group. Moreover, knockdown of BDNF-AS increased the expression levels of apoptosis-related proteins (cleaved caspase 3 and cleaved PARP), while knockdown of miR-125a-5p or miR-125b-5p reduced the expression levels of these apoptosis-related proteins compared with knockdown of BDNF-AS. Furthermore, knockdown of BDNF-AS effectively suppressed MM tumor growth in vivo. Yes Knockdown of BDNF-AS effectively inhibited the proliferation and migration of MM.1S and U266 cells, and co-transfection of miR-125a-5p or miR-125b-5p inhibitor and sh-BDNF-AS enhanced cell proliferation and migration compared with that in sh-BDNF-AS group. 34980181 BICDL3P LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[miR-361-3p/PDPK1 signalling] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay In summary, ABHD11-AS1 boosts GC development by regulating miR-361-3p/PDPK1 signalling. Yes ABHD11-AS1 knockdown repressed cell proliferation but enhanced cell apoptosis in function. 32678870 BLACAT1 LncRNA Homo sapiens Glioma glioma tissues Regulation[BLACAT1/miR-605-3p/VASP axis] qRT-PCR BLACAT1 levels were increased in glioma tissues.Summarily, this study highlights the important roles of BLACAT1/miR-605-3p/VASP axis in glioma progression. Yes Silencing of BLACAT1 markedly repressed glioma proliferation, migration, and invasion, and suppressed glioma growth in vivo. 31093978 BASP1-AS1 LncRNA Homo sapiens Melanoma melanoma tissues Interaction(YBX1/NOTCH3) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//RIP//CHIP//Colony Formation Assay//Invasion Assay The expression of BASP1-AS1 was upregulated in melanoma tissues and various melanoma cell lines. Mechanically, BASP1-AS1 interacted with YBX1 and recruited it to the promoter of NOTCH3, initiating its transcription process. The activation of the Notch signaling then resulted in the transcription of multiple oncogenes, including c-MYC, PCNA, and CDK4, which contributed to melanoma progression. Yes Functionally, the ectopic expression of BASP1-AS1 promoted cell proliferation, migration, and invasion in both A375 and SK-MEL-2 cells. 34533860 BLACAT1 LncRNA Homo sapiens cervical squamous cell carcinoma CSCC tissue Expression[highly expressed] qRT-PCR//Transwell Assay We showed that BLACAT1 was upregulated in CSCC tissue comparing to adjacent non-cancer tissue of CSCC patients. Patients with higher BLACAT1 level in CSCC tissues showed a significantly lower overall 5-year survival rate. Yes Overexpression of miR-424 and miR-143 led to inhibited migration and invasion, while BLACAT1 overexpression led to promoted migration and invasion of CSCC cells. 32046460 BMI1 CircRNA Homo sapiens Esophageal Neoplasms serum and tissues of esophageal cancer patients Expression [lower expressed] Transfection//qPCR//Proliferation Assay//RIP//Cell Apoptosis Assay//PCR//Cell Proliferation Assay//IP//IF Expression of circ-BMI1 in serum and tissues of esophageal cancer patients was significantly decreased compared to controls (P < 0.001 and P = 0.003, respectively). Area under the receiver operating characteristic curve (ROC) was 0.726. Yes Cell proliferation, migration and colony forming ability of circBMI1-Eca109 cells were obviously decreased than that of NC-Eca109 cells (P < 0.05). circBMI1-Eca109 cells were more sensitive to 5-fluorouracil and cisplatin, and tumor volume of nude mice in circBMI1-Eca109 group was smaller (P < 0.05). 34278876 BM466146 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[lower expressed] CCK8//qRT-PCR//EdU Staining It was found that the expression of lncRNA BM466146 in breast cancer tissues was significantly lower than that in normal breast tissues (P < 0.001). Kaplan-Meier survival analysis showed that breast cancer patients with overexpression of BM466146 had longer overall survival. Yes EDU and CCK8 experiments showed that overexpression of BM466146 inhibited the proliferation of breast cancer cells. 33585256 Blnc1 LncRNA Mus musculus Cerebral Hemorrhage brain tissue regulation[PPAR-γ/SIRT6/FoxO3 pathway] Western Blot//CCK8//qRT-PCR//Cell Apoptosis Assay//ELISA//Transwell Assay Blnc1 was upregulated in perihematomal edema, hematoma and microvessel in the brain of ICH mice. Silencing Blnc1 alleviated nerve injury and inflammatory response caused by ICH through activating PPAR-γ/SIRT6/FoxO3 pathway. Yes Silencing Blnc1 restrained OGD plus hemin-caused reduction of BMVEC viability and migration and the induction of apoptosis, permeability and inflammation response, and suppressed PPAR-γ/SIRT6-mediated FoxO3 activation, which could be reversed by T0070907 (PPAR-γ inhibitor). 33359247 BLACAT2 LncRNA Homo sapiens Stomach Neoplasms Primary gastric cancer tissues and the normal samples Interaction(miR-193b-5p/METTL3 pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Our study discovered that lncRNA-BLACAT2 was significantly upregulated in gastric cancer. Furthermore, BLACAT2 was verified to perform its function through interaction with miR-193b-5p using a luciferase reporter assay. Additional studies also discovered that Methyltransferase Like 3 (METTL3) was the downstream target of miR-193b-5p. Yes Different studies have illustrated that BLACAT2 promoted gastric cancer progression through regulating proliferation, migration, invasion, and apoptosis in terms of biological function. 33976730 BLACAT1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[miR-150-5p/CCR2] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay We found BLACAT1 took part in breast cancer cell aggressive phenotype. The real-time PCR result showed that BLACAT1 was up-regulated in tumor tissues compared to adjacent normal tissues. The molecular mechanism experiments demonstrated that BLACAT1 down-regulation suppressed the proliferation and metastasis of human breast cancer cells by regulating miR-150-5p targeting CCR2. The clinical studies indicated that lack of BLACAT1 was related to tumor size, metastasis. Yes The molecular mechanism experiments demonstrated that BLACAT1 down-regulation suppressed the proliferation and metastasis of human breast cancer cells by regulating miR-150-5p targeting CCR2. 30733855 BLACAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Expression[highly expressed] qRT-PCR In our results, BLACAT1 expression was increased in SCLC tissues and cell lines compared with paired adjacent normal tissues and bronchial epithelial cell lines, respectively. In addition, BLACAT1 high-expression was obviously associated with advanced clinical stage, large tumor size, more lymph node metastasis, present distant metastasis, and poor prognosis. Yes The loss-of-function studies suggested that of BLACAT1 suppressed SCLC cell proliferation, migration, and invasion, and induced G0/G1 phase arrest. 30203450 BLACAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues Regulation(Sonic Hedgehog Pathway) qRT-PCR//Western Blot//Colony Formation Assay//Transwell Assay Here, we reported BLACAT1 was significantly up-regulated in lung cancer tissues in comparison to the adjacent normal tissues, which suggested BLACAT1 might act as an oncogene in lung cancer. Sonic hedgehog (shh) signaling is able to exert a significant role in carcinogenesis, including lung cancer. Currently, we proved that up-regulation of BLACAT1 activated shh signaling pathway, via inducing shh, Gli-1 and Smo expression. shh pathway inhibitor GANT-61 reversed the effect of overexpression of BLACAT1 on non-small cell lung cancer. Yes As shown, we proved up-regulation of BLACAT1 greatly induced the growth of non-small cell lung cancer cells. Reversely, knockdown of BLACAT1 reduced A549 and PC9 cell proliferation, migration and invasion. 33937028 BLACAT1 LncRNA Homo sapiens Colorectal Neoplasms colon tissues,cell lines Expression[highly expressed] CCK8//qRT-PCR BLACAT1 level was higher in CRC tissues and cell lines than in normal colon mucosal tissues and cell lines. Correlation of data from the GEO and GEPIA databases with several clinical parameters revealed that CRC patients with high BLACAT1 expression showed poor OS. Multivariate analysis indicated that high BLACAT1 expression is an independent risk factor in patients with CRC. Yes Furthermore, siRNA-mediated knockdown of BLACAT1 suppressed proliferation and invasion of CRC cells in vitro. 35116731 BLACAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[BLACAT1/miR-519d-3p/CREB1 Axis ] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay The expression of BLACAT1 was promoted in CRC tissues and cells, and correlated to the TNM (tumor, node, metastasis) stage, distant metastasis, and overall survival rate. Moreover, our data showed that miR-519d-3p directly targeted CREB1 and BLACAT1 sponged miR-519d-3p to regulate CREB1 expression. Besides, CREB1 disrupted the bio-functional results above from BLACAT1 suppression. The expression of BLACAT1 was promoted in CRC tissues and cells, and correlated to the TNM (tumor, node, metastasis) stage, distant metastasis, and overall survival rate. Yes Silencing of BLACAT1 limited the proliferation, migration, and invasion, facilitated the apoptosis, and re-sensitized OXA-resistance in CRC cells. 33376405 BLACAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Regulation[BLACAT1/ has-miR-485-5p regulatory axis ] qRT-PCR//Luciferase Report Assay BLACAT1was found to be overexpressed in both HCC cells and human HCC tumors.The BLACAT1/ has-miR-485-5p regulatory axis may be a molecular target for future HCC therapy. Yes In HeG2 and MHCC97 L cells, lentivirus-induced BLACAT1 downregulation inhibited cancer cellin vitro proliferation and invasion, and in vivo xenograft growth. 31174090 BLACAT1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues regulation[Wnt/β-catenin signaling pathway,miR-519d-3p] Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay Quantitative RT-PCR showed that BLACAT1 was aberrantly up-regulated in ovarian cancer tissues compared with normal tissues.Taken together, BLACAT1 knockdown inhibited the progression of ovarian cancer by suppressing the Wnt/β-catenin signaling pathway via regulating miR-519d-3p. Yes In vitro, BLACAT1 knockdown induced cell cycle arrest and inhibited the proliferation, migration and invasion of ovarian cancer cells using flow cytometry, MTT and EdU assays, wound healing assay and transwell assay, respectively. 32095930 BLACAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cell lines Interaction[targeting miR-142-5p] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expression of BLACAT1 was increased and the expression of miR-142-5p was decreased in OSCC cells.LncRNA BLACAT1 knockdown suppressed the viability, migration and invasion of OSCC cells by sponging miR-142-5p, indicating that BLACAT1 might be a novel target for the treatment of OSCC. Yes The knockdown of BLACAT1 suppressed the viability, migration and invasion of OSCC cells. 31841186 BLACAT1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction[regulating STAT3] qRT-PCR//RNA Pull-Down//Western Blot BLACAT1 was upregulated in OS tissues and cells. Upregulation of BLACAT1 predicted unfavorable prognosis for patients with OS. More importantly, BLACAT1 could interact with STAT3 and regulat the phosphorylation of STAT3. Yes Downregulation of BLACAT1 inhibited cell proliferation and invasion, whereas upregulation of BLACAT1 accelerated cell proliferation and invasion. 30665678 BLACAT1 LncRNA Homo sapiens Glioma lioma tissues and adjacent non-tumor tissues,cell lines (NHA,U251, T98G, H4, A172, LN229) Regulation[Wnt/β-catenin signaling pathway ] Western Blot//Wound Healing Assay//qPCR//Cell Proliferation Assay//Transwell Assay Results demonstrated that BLACAT1 mRNA expression was significantly increased in glioma tissues compared to adjacent non-tumor (ANT) tissues.Results determined that BLACAT1 was highly expressed in glioma cell lines (U251, T98G, H4, A172 and LN229) compared with the NHA cell line.In conclusion, BLACAT1 may serve as an oncogenic lncRNA in glioma progression via activation of the Wnt/β-catenin signaling pathway. Yes Functional assays determined that BLACAT1 promoted glioma cell proliferation, migration, invasion and epithelial-mesenchymal transition in vitro. 31086604 BLACAT1 LncRNA Homo sapiens Pancreatic Neoplasms regulation[Repressing CDKN1C via EZH2-Induced H3K27me3] qRT-PCR//Western Blot Based on bioinformatic prediction, EZH2 and BLACAT1 were highly expressed in PC, while CDKN1C was lowly expressed (all P < 0.05). Interference with BLACAT1 inhibits H3K27 trimethylation of CDKN1C gene by blocking EZH2 recruitment to promote CDKN1C expression and inhibit CCNE expression, thus suppressing PC cell proliferation, migration and aerobic glycolysis, and promoting mitochondrial oxidative phosphorylation. Yes Interference with EZH2 and BLACAT1 inhibited cell proliferation, migration and aerobic glycolysis, and promoted mitochondrial oxidative phosphorylation (all P < 0.05).In vivo results showed that BLACAT1 interference inhibited tumor formation (all P < 0.05). 33072570 BLACAT1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer samples Interaction(miR-29a-3p/DVL3 Axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay BLACAT1 expression was significantly up-regulated in cancerous tissues of prostate cancer samples and positively correlated with the expression of DVL3, while negatively associated with miR-29a-3p. the luciferase activity of BLACAT1 reporter was inhibited by miR-29a-3p, and DVL3 was validated as a target gene of miR-29a-3p. Yes After the transfection of BLACAT1 shRNAs into prostate cancer cells, the proliferative ability and metastatic ability of cancer cells were significantly inhibited; BLACAT1 shRNAs could reduce the expression of DVL3 on both mRNA and protein expressions levels, 33641528 BLACAT1 LncRNA Homo sapiens Melanoma Melanoma tissue and noncancerous tissue Interaction(miR-374b-5p/U2-associated factor homology motif kinase 1 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay the collected data showed that BLACAT1 was highly expressed in melanoma.BLACAT1 upregulated UHMK1 expression by acting as a competing endogenous RNA for miR-374-5b. BLACAT1 deficiency resulted in the upregulation of miR-374b-5p expression and the downregulation of UHMK1 expression in melanoma cells. Moreover, BLACAT1 activated PI3K and AKT signaling by upregulating UHMK1 expression, as shown by western blotting analyses. Yes Functionally, UHMK1 overexpression or miR-374b-5p knockdown reversed the suppressive effect of BLACAT1 depletion on melanoma cell proliferation and invasion. 34708547 BDNF-AS LncRNA Homo sapiens Prostatic Neoplasms CaP tumors, CaP cell lines Expression(lower expressed) qRT-PCR BDNF-AS was downregulated in human CaP tumors. BDNF-AS was also found to be lowly expressed in CaP cell lines. In LNCaP and PC-3 cells, lentivirus-driven BDNF-AS overexpression exerted significantly tumor-suppressing effects on hindering cancer cell proliferation and invasion in vitro, and explant growth in vivo. Low BDNF-AS expression was correlated with CaP patients' poor prognosis and shorter overall survival. Yes In LNCaP and PC-3 cells, lentivirus-driven BDNF-AS overexpression exerted significantly tumor-suppressing effects on hindering cancer cell proliferation and invasion in vitro, and explant growth in vivo. 29710528 BCYRN1 LncRNA Homo sapiens Breast Neoplasms breast cancer cells and tissue Expression[highly expressed] qRT-PCR//RNA-seq Our results show that BC200 is upregulated in nulliparous women, and breast cancer cells and tissue.  Yes When overexpressed in luminal and triple negative breast cancer cell lines, BC200 shows increased proliferation, migration, and invasion in vitro.In vivo, overexpression of BC200 increased tumor size. 31646972 BCYRN1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines(A549, SPC-A1, H460 and H1650) Interaction [Wnt/β-catenin pathway] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that BCYRN1 was increased in NSCLC, and its Expression[down-expression]regulated expression could sExpression[Expression[up-expression]-expression]press NSCLC cell proliferation and cell cycle progression by inhibiting the Wnt/β-catenin pathway. Our results showed that the expression of BCYRN1 was higher in lung cancer cells compared with a normal bronchial epithelial cell line. Moreover, Expression[down-expression]regulation of BCYRN1 expression could inhibit cell proliferation and migration and induce apoptosis. Yes KnockExpression[down-expression] of BCYRN1 in NSCLC cells reduced a cohort of molecules (β-catenin, c-Myc and cyclin D1) which are critical for cell proliferation and apoptosis. 30486938 BCYRN1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[PI3K/AKT pathway] CCK8//qRT-PCR//Western Blot//Transwell Assay Higher expression of BC200 was found in NSCLC tissues than that of adjacent normal tissues. Western blot results showed that protein expressions of PI3K, AKT and STAT3 were downregulated after BC200 knockdown in LC cells. Additionally, the IC50 in H1299/DDP cells transfected with si-BC200 was lower than in those transfected with si-NC. The apoptotic rate in H1299 cells transfected with si-BC200 was remarkably lower than those transfected with si-NC. BC200 expression was positively correlated with tumor stage, lymph node metastasis and distant metastasis of NSCLC patients, whereas not correlated to age and sex. Yes Knockdown of BC200 inhibited proliferation, invasion and migration of LC cells. 30779077 BCAR4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR-139-3p) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Here, we unraveled that lncRNA BCAR4 was upregulated in ESCC and predicted poor prognosis. Mechanistically, lncRNA BCAR4 sponged miR-139-3p to upregulate ELAVL1, thereby inhibiting p53/p21 pathway in ESCC cells. Here, we unraveled that lncRNA BCAR4 was upregulated in ESCC and predicted poor prognosis. Yes Functionally, lncRNA BCAR4 knockdown induced cell apoptosis and G1/S arrest, while inhibited cell proliferation and migration in vitro; conversely, overexpressing lncRNA BCAR4 promoted proliferation and metastasis. 33602031 BCAN-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical carcinoma tissues and cell lines regulation[RP11-284F21.9/miR-769-3p/PPWD1 axis ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay We found that RP11-284F21.9 was down-regulated in cervical carcinoma tissues and cell lines. Taken together, our results demonstrate that RP11-284F21.9 functions as tumor suppressor and regulates PPWD1 expression through competitively binding to miR-769-3p in cervical carcinoma, suggesting that RP11-284F21.9/miR-769-3p/PPWD1 axis could serve as a promising prognostic biomarker and therapeutic target for cervical carcinoma. Yes Overexpression of RP11-284F21.9 inhibits proliferation, invasion and migration of cervical carcinoma cells in vitro. 32936290 BCAN-AS1 LncRNA Homo sapiens lung carcinoma lung cell lines and tissues regulation[miR-627-3p/CCAR1] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay An increased expression of RP11?284F21.9 was identified in both lung carcinoma tissues and cells.Mechanistically, it was demonstrated that RP11‑284F21.9 promoted the proliferation and invasiveness of lung carcinoma cells, in part, via the regulation of miR‑627‑3p. Furthermore, cell division cycle and apoptosis regulator 1 (CCAR1) was identified as a target gene of miR‑627‑3p. Yes Knockdown of RP11?284F21.9 in lung carcinoma cells inhibited cell proliferation and invasion, but promoted cell apoptosis. 32945522 BC050642 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Interaction[down-regulating the expression of c-myc] CCK8//qRT-PCR//Colony Formation Assay//Cell Apoptosis Assay BC050642 levels showed distinctive increases in osteosarcoma tissues and cell lines compared with controls. BC050642 is up-regulated in osteosarcma and its over-expression promotes tumor development via down-regulating the expression of c-myc. Yes Up-regulated BC050642 could promote cell proliferation, induce colony formation and meanwhile inhibit cell apoptosis. 31397185 BC037916 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues regulation[miR-3145-3p] qRT-PCR Quantitative RT-PCR analysis showed that 86.0% (74/86) pancreatic cancer tissues had increased BC037916 expression as compared with normal counterparts.Further experiments suggested that BC037916 positively regulated the expression of Twist through miR-3145-3p. Yes Functionally, knockdown of BC037916 repressed cell proliferation, inhibited cell invasion, halted cell cycle progression, and promoted apoptosis in both PANC-1 and SW1990 cells. 33447050 BBOX1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-361-3p/Mucin 13 signaling axis) RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis The results showed that BBOX1-AS1 was significantly upregulated in GC tissues. MiR-361-3p was significantly downregulated in GC and counteracted the inhibitory effects of BBOX1-AS1 on GC progression. MUC13, which is targeted by miR-361-3p, is significantly upregulated in GC. MUC13 silencing inhibited GC progression was aborgated by miR-361-3p inhibitor. Yes Silencing of BBOX1-AS1 inhibited GC cell proliferation and invasion and inhibited tumor growth in vivo, whereas it promoted apoptosis. 36700475 BBOX1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction(HOXB7/β-catenin axis) Western Blot//Migration Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay Herein, we validated that BBOX1-AS1 was notably overexpressed in ESCC tissues compared to the adjacent non-tumor tissues and significantly correlated with tumor sizes. Mechanistically, BBOX1-AS1 regulated HOXB7 expression, and rescue experiments indicated that silencing of HOXB7 could abolish the malignant phenotypes mediated by BBOX1-AS1 to a certain extent. Moreover, HOXB7 participated in the activation of the Wnt/β-catenin signaling pathway. Yes BBOX1-AS1 enhanced the malignant behavior of ESCC cells in vitro, such as cell proliferation, migration, and invasion. In addition, knockdown of BBOX1-AS1 augmented the proportion of apoptotic cells in ESCC cells. 35351402 BBOX1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC cell lines Interaction(hsa-miR-361-3p/SH2B1) qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Western Blot We observed that BBOX1-AS1 is overexpressed in CRC cell lines, and BBOX1-AS1 knockdown enhances cell proliferation, migration and invasion while reducing cell apoptosis. miR-361-3p is present at a low level in CRC and is negatively modified by BBOX1-AS1. Moreover, miR-361-3p was validated to be targeted by BBOX1-AS1. Src homology 2 B adaptor protein 1 (SH2B1) was notably upregulated in CRC cell lines and was identified as a downstream gene of miR-361-3p. In addition, we found that miR-361-3p amplification can suppress the expression of SH2B1. Yes We observed that BBOX1-AS1 is overexpressed in CRC cell lines, and BBOX1-AS1 knockdown enhances cell proliferation, migration and invasion while reducing cell apoptosis. 31984680 BBOX1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-361-3p/PHF8 axis.) In Vivo Experiment Previously, we showed that lncRNA BBOX1-AS1 was highly expressed and played an oncogenic role in HCC. This study revealed that BBOX1-AS1 could promote tumor progression, autophagy, and drug resistance by upregulating PHF8 in HCC cells.Mechanistically, BBOX1-AS1 enhanced the stability of PHF8 mRNA by targeting the PHF8 inhibitor miR-361-3p to regulate tumor progression and autophagy in HCC. The functional rescue experiments showed that PHF8 acted as a key factor in regulating the biological effects induced by BBOX1-AS1 and miR-361-3p in HCC, indicating that BBOX1-AS1 promotes tumor progression and sorafenib resistance by regulating miR-361-3p/PHF8. Yes This study revealed that BBOX1-AS1 could promote tumor progression, autophagy, and drug resistance by upregulating PHF8 in HCC cells. 36699616 BBOX1-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells regulation[miR-361-3p/PODXL pathway] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay As a result, we demonstrated the extremely high BBOX1-AS1 expression in OC tissues and cells. All the results above explained that BBOX1-AS1 was overexpressed in OC and that BBOX1-AS1 caused carcinogenic influences on OC cell growth via miR-361-3p/PODXL pathway, highlighting BBOX1-AS1 as a novel potential target for OC treatment. Yes BBOX1-AS1 silence inhibited OC progression by suppressing cell proliferation and promoting cell apoptosis. 33159291 BBOX1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues regulation[HOXC6,miR-361-3p] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Microarray//Colony Formation Assay//Transwell Assay BBOX1 antisense RNA 1 antisense RNA 1 was revealed to be highly expressed in CC. Decreased expression of BBOX1-AS1 had suppressive effects on CC cell growth and migration.BBOX1 antisense RNA 1 facilitates CC progression by upregulating HOXC6 expression via miR-361-3p and HuR. Yes BBOX1 antisense RNA 1 antisense RNA 1 was revealed to be highly expressed in CC. Decreased expression of BBOX1-AS1 had suppressive effects on CC cell growth and migration. 32515533 BBOX1-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma carcinoma tissues&NPC cells Interaction(BBOX1-AS1/miR-3940-3/KPNA2 axis) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//EdU Staining//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay High BBOX1-AS1 levels were detected in the nasopharyngeal carcinoma tissues. BBOX1-AS1 silencing considerably suppressed the proliferative, migratory, and invasive abilities of NPC cells in vitro. Interestingly, BBOX1-AS1 could specifically bind to miR-3940-3 and abrogate the inhibition of KPNA2 induced by miR-3940-3. Additionally, analysis of tissue samples showed that miR-3940-3 was inversely correlated with BBOX1-AS1 and KPNA2. Yes BBOX1-AS1 silencing considerably suppressed the proliferative, migratory, and invasive abilities of NPC cells in vitro. 34938119 BBOX1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cells Interaction(miR-513a-3p/SLC7A11 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//IHC//EdU Staining//Transwell Assay BBOX1-AS1 expression was significantly higher in ESCC tissues, indicating poor prognosis.miR-513a-3p was verified as a specific target of BBOX1-AS1 in ESCC, whereas knockdown of miR-513a-3p reversed the suppressive function of BBOX1-AS1 silencing in TE-1 cells. Moreover, solute carrier family 7 member 11 (SLC7A11) is regulated by miR-513a-3p, which is mediated by BBOX1-AS1 in ESCC cells. BBOX1-AS1 expression was significantly higher in ESCC tissues, indicating poor prognosis. Yes Inhibition of BBOX1-AS1 reduced cell proliferation, slowed cell invasion and migration, and promoted apoptosis and ferroptosis in vitro. 36216119 BBOX1-AS1 LncRNA Homo sapiens lung squamous cell carcinoma LUSC tissues Expression(highly expressed) CCK8//qRT-PCR//Wound Healing Assay//Flow Cytometry The results of the RT-qPCR analysis and data obtained from the TCGA database, GEO datasets, in-house gene microarray and standard mean deviation analysis all supported the upregulated expression level of BBOX1-AS1 in LUSC. Yes Furthermore, silencing of BBOX1-AS1 inhibited the proliferation and migration of LUSC cells according to in vitro assays. In addition, the cells were arrested in S-phase after knockdown of BBOX1-AS1. 34820016 BBOX1-AS1 LncRNA Homo sapiens Pituitary Neoplasms pituitary adenoma tissues and cells Interaction(miR-361-3p/E2F1 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The expression of BBOX1-AS1 in pituitary adenoma tissues and cells has been increased, according to our findings. We identify BBOX1-AS1 bind to miR-361-3p and to suppress its expression in a negative way. Moreover, miR-361-3p has been shown to bind with E2F1 and inhibit its expression. E2F1 also corrected miR-361-3p-mediated cell invasion, proliferation and apoptosis in BBOX1-AS1-dysregulated pituitary adenoma cells in rescue tests. Yes Furthermore, it is also noted that downregulation of BBOX1-AS1causes the inhibition of pituitary adenoma cells which result in invasion, apoptosis and proliferation, as well as boosting tumor development in vivo . In addition, BBOX1-AS1 knockdown inhibited tumor development in vivo . 35324526 BBOX1-AS1 LncRNA Homo sapiens Primary Ovarian Insufficiency POF patients and granulosa cells Interaction(miR-146b) RNA Pull-Down//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay We found that the expression levels of BBOX1-AS1 were increased, while the expression levels of miR-146b were decreased in POF patients. BBOX1-AS1-WT, but not BBOX1-AS1-mut, directly interacted with miR-146b. Yes BBOX1-AS1 suppressed the role of miR-146b in cell apoptosis. Therefore, BBOX1-AS1 may increase the apoptosis of granulosa cells in POF by sponging miR-146b. 35188872 BBOX1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma EC tissues and cells Interaction(miR-361-3p/COL1A1 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay BBOX1-AS1 was remarkably elevated in EC tissues and cells.Moreover, BBOX1-AS1 was found to be a sponge of miR-361-3p, which downregulated miR-361-3p expression. MiR-361-3p inhibitor rescued the anti-tumour effect of BBOX1-AS1 knockdown on the progression of EC. Furthermore, we discovered that miR-361-3p specially bound to COL1A1 3'UTR and downregulated COL1A1 and COL1A1 reduction declined the promoting effect of silencing miR-361-3p on EC cell malignant phenotypes. Yes In addition, the silencing of BBOX1-AS1 attenuated the cell viability, cell migration and enhanced cell apoptosis of EC, as well as suppressed EC tumour formation in vivo. 36453878 BCAR4 LncRNA Homo sapiens Liver Neoplasms liver cancer tissues interaction[sponging miR-1261] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, the expression of lncRNA BCAR4 was notably elevated in liver cancer compared with adjacent non?tumor tissues. Collectively, the results of the present study demonstrated that lncRNA BCAR4 may promote liver cancer development by directly binding to miR‑1261 and targeting ANAPC11. Yes Functional in vitro assays demonstrated that knockdown of lncRNA BCAR4 inhibited the proliferation, migration and invasion of Huh?7 cells. 32319544 BCAR4 LncRNA Homo sapiens Liver Neoplasms LC tissues Expression[highly expressed] qRT-PCR//MTT//Colony Formation Assay//Transwell Assay The present study measured the expression levels of BCAR4 in LC cells and tissues, and discovered that BCAR4 was upregulated in LC tissues compared with adjacent normal tissues. Furthermore, high BCAR4 expression was associated with the presence of multiple tumors and advanced Tumor-Node-Metastasis stages (III/IV). Survival analysis found that high BCAR4 expression indicated poor overall survival (OS) and progression-free survival (PFS). By analyzing the risk factors of poor OS and PFS using univariate analysis and multivariate analysis, high BCAR4 expression was revealed to be an independent risk factor of poor prognosis. Yes In addition, the role of BCAR4 was further investigated in vitro, which revealed overexpression of BCAR4 to markedly promote the proliferation, migration and invasion of LC cells. Conversely, the loss of BCAR4 expression repressed the proliferation, migration and invasion of LC cells. 32782595 BCAR4 LncRNA Homo sapiens Glioma glioma tissues,cell lines Regulation[BCAR4/miR-2276/MMP7 axis] RNA Pull-Down//Western Blot//qPCR//CCK8//Transwell Assay BCAR4 expression was increased in glioma tissues and GBM cell lines, and its high expression positively correlated with advanced grades and worse prognosis.Our findings identified the essential roles of the BCAR4/miR-2276/MMP7 axis in gliomagenesis and provided novel insights on glioma therapy. BCAR4 expression was increased in glioma tissues and GBM cell lines, and its high expression positively correlated with advanced grades and worse prognosis. Yes Functional assays verified that knockdown of BCAR4-inhibited cell growth and invasion in vitro, and impaired tumor formation in vivo. 31849498 BCYRN1 LncRNA Homo sapiens Glioma regulation[miR-125a-5p] qRT-PCR//Wound Healing Assay//Transwell Assay Mechanistically, upregulated expression of BCYRN1 in glioma acts as a sponge to sequester the endogenous tumor suppressor miR-125a-5p and to further increase the expression TAZ. Yes The upregulation of BCYRN1 promoted the proliferation, migration and invasion of glioma cells. 32104095 BCYRN1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-30b-3p/ROCK1 axis) qRT-PCR//Luciferase Report Assay//Transwell Assay//Western Blot The expression levels of BCYRN1 and ROCK1 were upregulated in NSCLC tissues and cells, while miR-30b-3p was downregulated.LncRNA BCYRN1 was involved in the metastasis of NSCLC through modulating the miR-30b-3p/ROCK1 axis. Higher BCYRN1 expression indicated lymph node metastasis and advanced tumor-node-metastasis (TNM) stage of NSCLC patients. Yes Loss of BCYRN1 suppressed cell migration and invasion. In vivo, BCYRN1 silencing reduced the growth of A549 cells. 35225646 BCYRN1 LncRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues Regulation[NPR3 ] qRT-PCR The results showed that BCYRN1 expression was significantly upregulated in 96 CRC tumor tissues compared with para-carcinoma control tissues. Furthermore, NPR3 was identified to be a target of BCYRN1 and was downregulated by BCYRN1 knockdown. Additionally, BCYRN1 overexpression was associated with larger tumor size and advanced pathological stages in CRC patients. Yes In vitro BCYRN1 knockdown significantly inhibited the proliferation and apoptosis of CRC cells. 30114690 BCYRN1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines(HIEC,SW620) Expression[Expression[lower expressed]-expression] qRT-PCR//Western Blot " The results showed that the expres_x0002_sion level of lncRNA BCYRN1 in CRC tissues was significantly higher than that in para-cancer tissues (Figure 1). " "We performed a 60-month prognostic follow-Expression[Expression[up-expression]-expression] of these patients and analyzed their prognosis using the Kaplan-Meier method. Fortunately, no patient was lost to follow-Expression[Expression[up-expression]-expression]. The results were shown in Figure 2. Patients with high expression of lncRNA BCYRN1 had a poor prognosis, and their survival curve was significantly weaker than patients with low expression of lncRNA BCYRN1" Yes In vitro study, Expression[down-expression]-regulation of lncRNA BCYRN1 expression by si-BCYRN1 could significantly inhibit invasion and migration of CRC cells. 31773686 BCYRN1 LncRNA Homo sapiens Colorectal Neoplasms CRC tumour tissues and cell lines regulation[miR-204-3p/KRAS axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay " We found that compared with normal tissues and human intestinal epithelial cells (HIECs), CRC tumour tissues and cell lines had significantly increased BCYRN1 levels.Our findings suggest that BCYRN1 plays a carcinogenic role in CRC by regulating the miR-204-3p/KRAS axis. " Yes We further determined that knockdown of BCYRN1 inhibited the proliferation, migration, and invasion and promoted the apoptosis of CRC cells. 32944001 BCYRN1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC samples regulation[BCYRN1/miR-490-3p/POU3F2] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our results exhibited that BCYRN1 was over expressed in HCC samples, which was connected with unfavorable prognosis in HCC patients.BCYRN1, served as a competing endogenous RNA, up-regulated the expression of POU3F2 to promote the development of HCC through sponging miR-490-3p, supplying novel molecular targets and underlying prognostic biomarkers for HCC therapy. Yes In addition, a series of experiments exhibited that overexpression of BCYRN1 significantly expedited HCC cells growth, clone formation, and movement abilities, and vice versa. 31920461 BCYRN1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell and tissues Interaction(TM4SF1/BATF ) qRT-PCR BCYRN1 upregulation was associated with poorer clinical outcomes in HCC patients, and knocking down this lncRNA impaired HCC cell migration and invasion. From a mechanistic perspective, BATF was recruited to the TM4SF1 promoter by BCYRN1, and reducing the expression of this lncRNA was sufficient to constrain xenograft tumor growth in mice. BCYRN1 upregulation was associated with poorer clinical outcomes in HCC patients, and knocking down this lncRNA impaired HCC cell migration and invasion. Yes BCYRN1 upregulation was associated with poorer clinical outcomes in HCC patients, and knocking down this lncRNA impaired HCC cell migration and invasion. 35730016 BCYRN1 LncRNA Homo sapiens Urinary Bladder Neoplasms urinary-EXO from patients with BCa Regulation（WNT5A/VEGF-C/VEGFR3 ） qRT-PCR//ChIP LncRNA BCYRN1 was substantially upregulated in urinary-EXO from patients with BCa, and associated with the LN metastasis of BCa. Mechanistically, BCYRN1 epigenetically upregulated WNT5A expression by inducing hnRNPA1-associated H3K4 trimethylation in WNT5A promoter, which activated Wnt/β-catenin signaling to facilitate the secretion of VEGF-C in BCa. Yes We demonstrated that exosomal BCYRN1 markedly promoted tube formation and migration of human lymphatic endothelial cells (HLECs) in vitro and lymphangiogenesis and LN metastasis of BCa in vivo. 34323412 BCYRN1 LncRNA Homo sapiens Glioma glioma tissues regulation[PTEN/AKT/p21 pathway] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//migration assay//Colony Formation Assay Among them, BCYRN1 was the most downregulated lncRNA, and its low expression positively correlated with glioma progression. BCYRN1 functioned as a ceRNA to inhibit glioma progression by sponging miR-619-5p to regulate CUEDC2 expression and PTEN/AKT/p21 pathway. Yes Functionally, BCYRN1 overexpression inhibited cell proliferation, migration in glioma cell lines, whereas BCYRN1 depletion resulted in the opposite way. 32978519 BCYRN1 LncRNA Homo sapiens Liver Neoplasms HCC tissues Expression[highly expressed] CCK8//qRT-PCR//Western Blot//Transwell Assay In the present study, it was found that BC200 expression level was higher in hepatocellular carcinoma (HCC) tissues than that in adjacent tissues. Interestingly, it was found that BC200 affected the expression of c‑Myc protein but did not affect the mRNA expression level of c‑MYC. BC200 KO cells exhibited a reduced protein expression level of Bax protein and an increased protein expression level of Bcl‑xL. Conversely, BC200 overexpression reduced the expression of Bcl‑xL protein and increased the expression of Bax protein. Importantly, it was found that BC200 affected the formation of subcutaneous tumors in nude mice. In conclusion, the present results suggested that lncRNA BC200 may play an important role in liver cancer. Yes Cell function was examined by constructing BC200 knockout (KO) and BC200‑overexpression in vitro models. It was found that BC200 affected the proliferation and migration of HepG2 cells. 31894342 BCAR4 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer cell lines interaction[miR-644a,TLX1 ] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The expression of BCAR4 was higher in bladder cancer cell lines than normal urothelial cell line. We showed that BCAR4 sponged miR-644a to modulate the expression of TLX1 and promote bladder cancer development. Moreover, the expression of BCAR4 was associated with the advanced stage and metastasis of bladder cancer. Yes Through knockdown of BCAR4, we discovered that knockdown of BCAR4 significantly decreased the proliferation, migration and invasive abilities of bladder cancer cells. 32273720 BCYRN1 LncRNA Homo sapiens stomach carcinoma GC samples and cell lines Regulation(EpCAM) Western Blot//Transfection//Flow Cytometry//qRT-PCR//migration assay//Cell Proliferation Assay//Colony Formation Assay We found BCYRN1 was significantly upregulated in GC samples, and its expression was positively correlated with advanced TNM stage (p = 0.0012) and tumor size (p = 0.027).Moreover, the results of RT-qPCR and western blotting indicated that knockdown of BCYRN1 notably decreased the expression of epithelial cell adhesion molecules (EpCAM). Otherwise, overexpression of BCYRN1 in GC cells (BGC-823 and SGC-7901) could reverse the effects of BCYRN1 knockdown. We found BCYRN1 was significantly upregulated in GC samples, and its expression was positively correlated with advanced TNM stage (p = 0.0012) and tumor size (p = 0.027). Yes Functionally, BCYRN1 knockdown by siRNA could inhibit cell proliferation, induce G1/G0 cell cycle arrest, increase apoptosis and impair migratory ability of AGS cells. 29435146 BCYRN1 LncRNA Homo sapiens Myelodysplastic Syndromes MDS patients, MDS cells Interaction(LncRNA BC200/miR-150-5p/MYB ) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//EdU Staining//ChIP we found that BC200 was highly expressed in MDS patients compared with normal individuals. Mechanistic investigations revealed that BC200 functioned as a miRNA sponge to positively regulate the expression of MYB through sponging miR-150-5p and subsequently promoted malignant proliferation of MDS cells. Conversely, we found that BC200 was a direct transcriptional target of MYB, and knockdown of MYB abolished the oncogenic effect of BC200/miR-150-5p. Yes Knockdown of BC200 inhibited MDS cell proliferation, colony formation, and cell cycle progression in vitro and suppressed the growth and invasiveness of MDS cells in vivo. 35136029 BCRC-3 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cell lines Regulation[miR-182-5p/p27 axis] Flow Cytometry//Western Blot//PCR//IF BCRC-3 was lowly expressed in bladder cancer tissues and cell lines.BCRC-3 functions as a tumor inhibitor to suppress BC cell proliferation through miR-182-5p/p27 axis, which would be a novel target for BC therapy. Yes Proliferation of BC cells was suppressed by ectopic expression of BCRC-3 in vitro and in vivo. 30285878 BCLIN25 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[upregulating ERBB2] Western Blot//Tunel//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay Mechanistically, BCLIN25 was shown to increase the expression of ERBB2 by enhancing promoter CpG methylation of miR-125b, leading to miR-125b downregulation. In turn, ERBB2 mRNA degradation was found to be abolished due to decreased binding of miR-125b to the 3'-untranslated region (UTR) of ERBB2. These findings reveal the role of novel lincRNAs in breast cancer and provide a comprehensive landscape of breast cancer MS-lincRNAs, which may complement the current molecular classification system in breast cancer. Yes BCLIN25 was found to contribute to tumorigenesis in vitro and in vivo. 31801944 BCAR4 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[MAPK/ERK signaling] CCK8//qRT-PCR//Colony Formation Assay//Flow Cytometry LncRNA BCAR4 was highly expressed in both GC tissues and cell lines.Besides, Western blotting revealed that lncRNA BCAR4 played an oncogenic role in GC via regulating MAPK/ERK signaling. Yes CCK-8 assay, colony formation assay, and flow cytometry results indicated that up-regulated lncRNA BCAR4 significantly promoted cell proliferation and suppressed cell apoptosis in GC. 32329841 BCAR4 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction[GLI2] qRT-PCR//IHC//Transwell Assay qRT-PCR was used to determine the expression of BCAR4 and GLI2 downstream genes in NSCLC tissues and cell lines. The expression of BCAR4 in NSCLC tissues and cells was significantly higher than the normal level. In summary, the cooperative mechanism of lncRNA BCAR4 and GLI2 might provide a new opportunity for treating NSCLC. Yes The overexpression of BCAR4 promoted NSCLC cell viability, migration, and invasion. The suppression of BCAR4 and GLI2 showed the opposite effects. 29615150 BCAR4 LncRNA Homo sapiens Carcinoma, Hepatocellular LO2 cells Regulation(LATS2) Luciferase Report Assay//Invasion Assay//Migration Assay The relative expression of LncRNA BCAR4 in HepG2 cells was critically higher than that in LO2 cells (P<0.05), while LATS2 mRNA in HepG2 cells was significantly less than that in LO2 cells (P<0.05).LncRNA BCAR4 can regulate the LATS2 expression, and inhibiting the expression of LncRNA BCAR4 can inhibit proliferation, invasion of HepG2 cells and induce its apoptosis, which finding provides a certain reference for the targeted therapy of liver cancer. Yes LncRNA BCAR4 can regulate the LATS2 expression, and inhibiting the expression of LncRNA BCAR4 can inhibit proliferation, invasion of HepG2 cells and induce its apoptosis, which finding provides a certain reference for the targeted therapy of liver cancer. 34150042 BCAR4 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Regulation[Wnt signaling] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay In the present study, elevated levels of lncRNA breast cancer anti‑estrogen receptor 4 (BCAR4) were identified in BC tissues compared with matched healthy tissues.Downregulation of BCAR4 led to the inactivation of Wnt signaling. Mechanistically, BCAR4 directly sponged microRNA (miR)‑370‑3p and elevated Wnt7a expression. Endogenous expression of Wnt7a reversed BCAR4 silencing‑mediated cell growth arrest and induction of apoptosis in BC cells accompanied with a re‑activation of Wnt signaling. Reverse transcription‑quantitative PCR indicated that there was a strong association between BCAR4, miR‑370‑3p and Wnt7a expression in tumors from patients with BC compared with healthy control tissues. Yes Silencing of BCAR4 inhibited cell proliferation and induced apoptosis in BC cell lines 5637 and T24. 31894304 MANCR LncRNA Homo sapiens Thyroid Carcinoma, Anaplastic ATC tissues,cell lines Expression[highly expressed] CCK8//qRT-PCR//Transwell Assay One of the lncRNAs, mitotically associated long non-coding RNA (MANCR; LINC00704), was significantly overexpressed in ATC cell lines and patient samples compared with NT and papillary thyroid cancer (PTC). Yes MANCR depletion in ATC cells significantly inhibited cancer cell proliferation and invasion, and induced apoptosis. 33178758 MANCR LncRNA Homo sapiens esophageal carcinoma esophageal carcinomas tissues Interaction(PDE4D) Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay MANCR was highly expressed in esophageal carcinomas tissues than non-tumoral ones. PDE4D was the target gene binding MANCR, which was downregulated in esophageal carcinoma tissues. Its level was negatively regulated by MANCR. Importantly, PDE4D could abolish the role of MANCR in stimulating the malignant progression of esophageal carcinoma. Yes MANCR promoted proliferative ability and inhibited apoptosis in TE-1 and EC-109 cells. In nude mice with xenografted esophageal carcinoma, knockdown of MANCR markedly slowed down tumor growth. 34565013 SLC16A1-AS1 LncRNA Homo sapiens Glioblastoma GBM tissues Interaction(miR-149) CCK8//qRT-PCR//Colony Formation Assay We found that SLC16A1-AS1 expression was upregulated in GBM tissues, and the upregulated expression of SLC16A1-AS1 predicted poor survival of GBM patients. MiR-149 was downregulated in GBM tissues and inversely correlated with the expression of SLC16A1-AS1. In GBM cells, overexpression of SLC16A1-AS1 downregulated the expression of miR-149 and increased the methylation of miR-149 gene. We found that SLC16A1-AS1 expression was upregulated in GBM tissues, and the upregulated expression of SLC16A1-AS1 predicted poor survival of GBM patients. Yes . In cell proliferation and colony formation assay, overexpression of SLC16A1-AS1 reduced the inhibitory effects of miR-149 on GBM cell proliferation. 33603467 SLC16A1-AS1 LncRNA Homo sapiens Breast Neoplasms BC patients and cells Interaction(miR-552-5p/WIF1 Signaling Pathway) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Transwell Assay Lower SLC16A1-AS1 expression in BC tissues was related to poor prognosis of BC patients. Lower SLC16A1-AS1 expression in BC tissues was related to poor prognosis of BC patients. Lower SLC16A1-AS1 expression in BC tissues was related to poor prognosis of BC patients. Yes Lower SLC16A1-AS1 expression in BC tissues was related to poor prognosis of BC patients. 35372039 SLC16A1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Expression[lower expressed] Western Blot//ISH//CCK8//qRT-PCR//Flow Cytometry//MTT//IHC It was showed that SLC16A1-AS1 was remarkably downregulated in NSCLC tissues and cell lines. Clinical sample analysis showed that SLC16A1-AS1 had a favorable impact on the overall survival and progression-free survival of patients with NSCLC. Yes Functionally, SLC16A1-AS1 overexpression could inhibit the viability and proliferation of lung cancer cell, block the cell cycle and promote cell apoptosis in vitro which may result from reduced phosphorylation of rat sarcoma (RAS)/ proto-oncogene serine/threonine-protein kinase (RAF)/ mitogen-activated protein kinase kinase (MEK)/ extracellular regulated protein kinases (ERK) pathway caused by elevated expression of SLC16A1-AS1. 31371390 SLC16A1-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC cells and tissues Interaction(miR-143-3p/SLC7A11 Signaling) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//FISH//Flow Cytometry//Luciferase Report Assay//IHC//Transwell Assay Our study revealed that SLC16A1-AS1 has high expression and was associated with overall survival in renal cancer. The present results suggest that silencing lncRNA SLC16A1-AS1 can induce ferroptosis through miR-143-3p/SLC7A11 signaling in renal cancer. Our study revealed that SLC16A1-AS1 has high expression and was associated with overall survival in renal cancer. Yes Knockdown SLC16A1-AS1 inhibited cell viability, proliferation, and migration of renal cancer cells. 35167383 SLC16A1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC patients and cells Interaction(miR-141) qRT-PCR SLC16A1-AS1 was upregulated in HCC and its high expression levels predicted poor survival of HCC patients. Expression levels of miR-141 were lower in HCC patients and were inversely correlated with the expression levels of SLC16A1-AS1. In HCC cells, overexpression of SLC16A1-AS1 led to downregulation of miR-141, while overexpression of miR-141 did not regulate the expression of SLC16A1-AS1. In addition, overexpression of SLC16A1-AS1 led to increased methylation of miR-141. SLC16A1-AS1 was upregulated in HCC and its high expression levels predicted poor survival of HCC patients. Yes And overexpression of SLC16A1-AS1 attenuated the inhibitory effects of miR-141 on HCC cell proliferation. 33744723 SLC16A1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-411/MITD1 axis) Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Invasion Assay The expression of SLC16A1-AS1 markedly increased in HCC tissues and cell lines. Subsequent studies identified SLC16A1-AS1 as a downstream target of miR-411. In addition, SLC16A1-AS1 knockdown and miR-411 overexpression significantly stagnated the progression of HCC cells. SLC16A1-AS1 knockdown also downregulated MITD1 levels. Yes In addition, SLC16A1-AS1 knockdown and miR-411 overexpression significantly stagnated the progression of HCC cells. 35293026 SLC16A1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC samples Expression[highly expressed] Flow Cytometry//qRT-PCR//Western Blot To identify the differentially expressed lncRNAs between OSCC tissue and normal tissue, RNA-Seq data were used. lncRNA SLC16A1-AS1 was significantly highly expressed in OSCC samples than that in normal samples. Systematic bioinformatics analysis revealed that SLC16A1-AS1 was associated with histological tumor grades and overall survival status, as well as copy number variation, somatic mutation, tumor mutation burden, tumor stemness, tumor microenvironment and infiltrating immune cells. Yes Loss-of-function experiments were performed to determine the biological functions of SLC16A1-AS in OSCC cells. Silencing SLC16A1-AS1 significantly reduced the cell proliferation rate and colony-forming ability in both CAL27 and SCC25 cell lines. 32450050 SLC16A1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissue samples, OSCC cells Interaction(miR-5088-5p) BrdU//qRT-PCR//RNA Pull-Down OSCC tissue samples exhibited decreased expression levels of SLC16A1-AS1 and premature miR-5088-5p, but increased the expression levels of mature miR-5088-5p. SLC16A1-AS1 was detected in both nucleus and cytoplasm samples of OSCC cells and its direct interaction with premature miR-5088-5p was confirmed. Overexpression of SLC16A1-AS1 in OSCC cells resulted in inhibited maturation of miR-5088-5p. SLC16A1-AS1 suppressed the enhancing effects of miR-5088-5p on cell proliferation. SLC16A1-AS1 was downregulated in OSCC and it may inhibit cell proliferation by suppressing maturation of miR-5088-5p. Yes SLC16A1-AS1 was detected in both nucleus and cytoplasm samples of OSCC cells and its direct interaction with premature miR-5088-5p was confirmed. Overexpression of SLC16A1-AS1 in OSCC cells resulted in inhibited maturation of miR-5088-5p. SLC16A1-AS1 suppressed the enhancing effects of miR-5088-5p on cell proliferation. SLC16A1-AS1 was downregulated in OSCC and it may inhibit cell proliferation by suppressing maturation of miR-5088-5p. 35829849 SLC16A1-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Interaction(miR-182/PDCD4 axis) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay SLC16A1-AS1 expression was downregulated in TNBC tissues. SLC16A1-AS1 interacted with miR-182, whereas SLC16A1-AS1 and miR-182 overexpression failed to affect their expression. SLC16A1-AS1 overexpression upregulated the expression of PDCD4, a downstream target of miR-182. SLC16A1-AS1 and PDCD4 overexpression suppressed cell cycle progression from the G1 phase to the G2 phase. MiR-182 and silencing of PDCD4 played the opposite role. Yes Additionally, miR-182 overexpression inhibited the role of SLC16A1-AS1 overexpression on cell cycle progression in both BT-549 and BT20 cells. The cell proliferation assay showed that SLC16A1-AS1 and PDCD4 overexpression decreased the cell proliferation rate. 35316129 SLC16A1-AS1 LncRNA Homo sapiens Glioblastoma LN-229 , LN-18 cells and tissues Interaction( miR-1269 ) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//BrdU//Transwell Assay SLC16A1-AS1 was also overexpressed in GBM. The direct interaction of SLC16A1-AS1 with premature miR-1269 was observed. SLC16A1-AS1 partly reversed the effects of miR-1269 on GBM cell proliferation, movement and apoptosis. Yes SLC16A1-AS1 suppressed miR-1269 maturation and promoted cell proliferation, migration, and invasion, and inhibited cell apoptosis, while miR-1269 displayed the opposite trend. Moreover, SLC16A1-AS1 overexpression increased the level of ki-67, CDK4 and Bcl-2 in LN-229 and LN-18 cells. 35609320 SLC25A21-AS1 LncRNA Homo sapiens Glioma glioma specimens and cell lines Interaction(miR-221-3p/miR-222-3p) Transfection//Invasion Assay//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis//Transwell Assay SLC25A21-AS1 was significantly downregulated in glioma specimens and cell lines compared to non-cancerous ones. miR-221-3p/miR-222-3p were the target miRNAs for SLC25A21-AS1. Overexpression of SLC25A21-AS1 inhibited glioma cell growth, invasion, and migration while miR-221-3p/miR-222-3p-overexpressed groups could offset this effect.Downregulation of SLC25A21-AS1 in gliomas carries a universally poor prognosis. Overexpression of SLC25A21-AS1 inhibited glioma progression via miR-221-3p/miR-222-3p. Significant associations were found between SLC25A21-AS1 downregulation and WHO stage, IDH status, poor disease-free survival/overall survival. Yes miR-221-3p/miR-222-3p were the target miRNAs for SLC25A21-AS1. Overexpression of SLC25A21-AS1 inhibited glioma cell growth, invasion, and migration while miR-221-3p/miR-222-3p-overexpressed groups could offset this effect. 35266110 SLC16A1-AS1 LncRNA Homo sapiens cervical squamous cell carcinoma CSCC and non-tumor tissue samples Interaction(miR-194/SOCS2 Axis) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay SLC16A1-AS1 was down-regulated in CSCC and correlated with poor survival. In addition, SLC16A1-AS1 could sponge miR-194 and increase the expression levels of SOCS2, ultimately inhibiting the proliferation of cervical cancer cells. SLC16A1-AS1 was down-regulated in CSCC and correlated with poor survival. Yes Overexpression of SLC16A1-AS1 could inhibit the proliferation of cervical cancer cells. 33603475 hsa_circ_0119872 CircRNA Homo sapiens Uveal melanoma UM cell lines and tissues Interaction(circ_0119872/miR-622/G3BP1 axis) qRT-PCR//Luciferase Report Assay//Western Blot We found that circ_0119872 is upregulated in UM cell lines and tissues. Moreover, overexpression of circ_0119872 promotes the malignancy of UM cells, while silencing of circ_0119872 inhibits it. In addition, circ_0119872 can directly interact with miR-622 as a miRNA sponge that regulates the expression of the miR-622 target gene G3BP1 as well as downstream Wnt/β-catenin and mTOR signalling pathways. Yes overexpression of circ_0119872 promotes the malignancy of UM cells, while silencing of circ_0119872 inhibits it. 33579337 SH3PXD2A-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation(p53) ISH//Wound Healing Assay//qRT-PCR//RIP//FISH//ChIP RNA ISH revealed that SH3PXD2A-AS1 was overexpressed in CRC compared with adjacent normal colon tissues and indicated poor prognosis in CRC. Mechanistically, SH3PXD2A-AS1 can directly interact with p53 protein and regulate p53-mediated gene transcription in CRC. RNA ISH revealed that SH3PXD2A-AS1 was overexpressed in CRC compared with adjacent normal colon tissues and indicated poor prognosis in CRC. Yes Functional analyses showed that SH3PXD2A-AS1 enhanced cell proliferation, angiogenesis, and metastasis. 34131400 circFNDC3B CircRNA Homo sapiens microinvasive gastric cancer gastric cancer (GC) cells and patients Interaction(miR-942/CD44 and miR-510/CDH1) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//IHC In summary, our study demonstrated that a higher level of circFNDC3B could lead to the increased expression of CD44 and CDH1 via modulating the signaling pathways of miR-942/CD44 and miR-510/CDH1 in EGC patients. Yes And circFNDC3B was proved to increase the migration and invasion of gastric cancer (GC) cells. 35418175 SGO1-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML patients and cell Regulation qRT-PCR We demonstrated that SGOL1-AS1 interacts with chromatin-modifying proteins involved in gene repression and that SGOL1-AS1 knockdown is associated with increased heterochromatin formation. In AML patients, high expression of SGOL1-AS1 correlates with both pro-inflammatory gene expression and poor survival. Altogether, our data reveal that SGOL1-AS1 is an essential regulator of cell survival in AML cell lines and a possible regulator of pro-inflammatory signaling in AML patients. In AML patients, high expression of SGOL1-AS1 correlates with both pro-inflammatory gene expression and poor survival. Yes We also observed that loss of SGOLl-AS1 results in increased apoptosis and the downregulation of pro-inflammatory genes. 36387443 SGO1-AS1 LncRNA Homo sapiens stomach carcinoma gastric carcinoma tissues Interaction(TGFB1/2/PTBP1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//ISH//Transfection//qRT-PCR//RIP//RNA-seq//Luciferase Report Assay//Microarray//Cell Proliferation Assay//ChIP SGO1-AS1 was downregulated in gastric carcinoma tissues compared to adjacent normal tissues, and its downregulation was positively correlated with advanced clinical stage, metastasis status and poor patient prognosis. Mechanistically, SGO1-AS1 facilitated TGFB1/2 mRNA decay by competitively binding the PTBP1 protein, resulting in reduced TGFβ production and, thus, preventing the epithelial-to-mesenchymal transition (EMT) and metastasis. In addition, in turn, TGFβ inhibited SGO1-AS1 transcription by inducing ZEB1. Yes The functional experiments revealed that SGO1-AS1 inhibited GC cell invasion and metastasis in vitro and in vivo. 34706749 SGMS1-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cells and tissues Interaction(miR-106a-5p/MYLI9 axis) qRT-PCR//Luciferase Report Assay//Migration Assay//Colony Formation Assay SGMS1-AS1 was downregulated in LUAD tissue as well as cells, which was related to good prognosis of patients with lung adenocarcinoma. Furthermore, miR-106a-5p was the direct target of SGMS1-AS1 and transfecting miR-106a-5p inhibitor could reversed the impact induced by knockdown of SGMS1-AS1. Subsequently, we found that MYLIP was the target of miR-106a-5p, which was negatively correlated with miR-106a-5p, but had high positive correlation with SGMS1-AS1. SGMS1-AS1 was downregulated in LUAD tissue as well as cells, which was related to good prognosis of patients with lung adenocarcinoma. Yes Additionally, knockdown of SGMS1-AS1 promoted proliferation, migration, invasion, and epithelial mesenchymal transition (EMT) progression of LUAD cells, which meant that SGMS1-AS1 inhibited the progression of LUAD cells. 34061466 circCTNNB1 CircRNA Homo sapiens Cerebral Ischemia/Reperfusion Injury OGD/R-treated mAS cells Interaction(miR-96-5p/SRB1 ) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//ELISA//IF CircCTNNB1 and SRB1 interacted with miR-96-5p, and the overexpression of miR-96-5p efficiently reversed the function of circCTNNB1 in OGD/R-treated mAS cells. CircCTNNB1 protected against cerebral ischemia-reperfusion injury by up-regulating SRB1 in vivo. Yes Overexpression of circCTNNB1 alleviated cell apoptosis, oxidative stress and the inflammatory response induced by OGD/R in vitro. Up-regulation of circCTNNB1 increased SRB1 expression levels to protect mAS cells from OGD/R-induced damage. 35435123 circLPAR1 CircRNA Homo sapiens Urinary Bladder Neoplasms MIBC tissues Interaction[miR-762] qRT-PCR//Wound Healing Assay//Luciferase Report Assay//RNA-seq circLPAR1 was identified to be lowly expressed in MIBC tissues in a cohort of 125 cases, and predicted a poor disease-specific survival time, compared with patients with high circLPAR1 expression (52.4 vs. 56.0 months; P=0.001) by univariate and multivariate Cox regression analyses. circLPAR1 was identified to be lowly expressed in MIBC tissues in a cohort of 125 cases, and predicted a poor disease-specific survival time, compared with patients with high circLPAR1 expression (52.4 vs. 56.0 months; P=0.001) by univariate and multivariate Cox regression analyses. Yes Matrigel and wound healing assays also demonstrated that the invasion of 5637 and T24 bladder cancer cells were significantly enhanced following the knockdown of circLPAR1 by small interfering RNA (si-circLPAR1-1 in T24 cell line, P=0.01; si-circLPAR1-2 in 5637 cell line, P=0.003; si-circLPAR1-2 in T24 cell line, P=0.002; si-circLPAR1-2 in 5637 cell line, P=0.006). 30867795 SLC25A21-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma PA tisssues Interaction(NPM1/c-Myc axis and SLC25A21) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//ChIP LncRNA SLC25A21-AS1 expression was downregulated by PA and associated with the proliferation and migration of ESCC cells in vitro and in vivo. SLC25A21-AS1 promotes the proliferation and migration of ESCC cells by regulating the NPM1/c-Myc axis and SLC25A21 expression. Yes LncRNA SLC25A21-AS1 expression was downregulated by PA and associated with the proliferation and migration of ESCC cells in vitro and in vivo. 35735113 SFTA3 LncRNA Homo sapiens Pulmonary Arterial Hypertension PAs of PAH patients and hypoxic human pulmonary artery smooth muscle cells (PASMCs) Interaction(miR-23a-3p) Western Blot//Transfection//CCK8//RIP//Flow Cytometry//qRT-PCR//Luciferase Report Assay//H&E Staining//Cell Proliferation Assay//Cell Cycle Assay//EdU Staining LncRNA PAHRF was down-regulated in both the PAs of PAH patients and hypoxic human pulmonary artery smooth muscle cells (PASMCs). Luciferase activity assay proved molecular binding between PAHRF and hsa-miR-23a-3p. Moreover, MST1 was confirmed to be the putative target gene and regulated by PAHRF/miR-23a-3p. In addition, we explored the molecular mechanism regulating the expression of miR-23a-3p, and found that lncRNA PAHRF acted as an endogenous sponge for miR-23a-3p, and silencing lncRNA PAHRF could up-regulate the expression of miR-23a-3p. Yes The overexpression of PAHRF inhibited the proliferation and promoted the apoptosis of PASMCs. Similarly, we also found PAHRF overexpression decreased the proliferation under hypoxia condition. Knockdown of PAHRF exerted the opposite effects. 34126237 SLC44A3-AS1 LncRNA Homo sapiens Glioblastoma GBMs Regulation( NF-κB signaling ) In Vivo Experiment//cell invasion assay//Western Blot//ISH//Transfection//Flow Cytometry//qRT-PCR//RIP//Cell Proliferation Assay//IHC//IF Here, we report that LINC01057 as a lncRNA is overexpressed in GBMs, especially in MES subtype. LINC01057 interacts with IKKα and maintains IKKα nucleus localization, leading to effective chromatin accessibility at NF-κB responsive promoters via histone modification and final NF-κB activation. IKKα knockdown disrupts the effect of LINC01057 overexpression on PN to MES transition (PMT). LINC01057 level is negatively correlated with patient prognosis in MES-subtype GBM. Yes LINC01057 knockdown suppresses proliferation, invasion and radioresistance of GBM cells in vitro, and tumor growth in vivo. LINC01057 knockdown leads to loss of MES signature in MES subpopulation of GBM cells, but LINC01057 overexpression promotes MES differentiation in proneural (PN) subpopulation. 33130316 SLCO4A1 LncRNA Homo sapiens Mucocutaneous Lymph Node Syndrome serum of KD patients, HUVECs Interaction(miR-335-5p/POU5F1 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Tunel//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA//Bioinformatics Analysis LncRNA Slco4a1 was significantly upregulated in the serum of KD patients compared with healthy controls. LncRNA Slco4a1 was upregulated in human umbilical vein endothelial cells (HUVECs) stimulated with KD serum.lncRNA Slco4a1 is a sponge of miR-335-5p and negatively regulated the expression of miR-335-5p. POU5F1 was the downstream target of miR-335-5p, and miR-335-5p overexpression could upregulate the expression of POU5F1. Yes LncRNA Slco4a1 overexpression could promote the expression of inflammatory factors and apoptosis in HUVECs. The number of inflammatory cells and the infiltration area of the coronary artery in KD rats were decreased after lncRNA Slco4a1 silencing. 35282018 Slco3a1-206 LncRNA Rattus norvegicus Arthritis, Gouty THP-1 cell line Regulation(AP3D1) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//H&E Staining//ELISA SNHG8 expression was identified to be upregulated after MSU treatment. Ablation of SNHG8 decreased the MSU-induced enhancement of paw swelling and foot thickness. In addition, SNHG8 depletion decreased the protein levels of proinflammatory factors in GA mice. Mechanically, SNHG8 was verified to be a sponge of miR-542-3p, and miR-542-3p targeted AP3D1 3' untranslated region. SNHG8 competitively bound with miR-542-3p to upregulate AP3D1 expression. Finally, results of rescue assays illustrated that AP3D1 upregulation offset the SNHG8-mediated inhibition on paw swelling and protein levels of proinflammatory factors in GA mice. In conclusion, SNHG8 accelerates acute GA development by upregulating AP3D1 in an miR-542-3p-dependent way in mice, providing an effective therapeutic approach to treat acute GA. Yes Ablation of SNHG8 decreased the MSU-induced enhancement of paw swelling and foot thickness. In addition, SNHG8 depletion decreased the protein levels of proinflammatory factors in GA mice. Mechanically, SNHG8 was verified to be a sponge of miR-542-3p, and miR-542-3p targeted AP3D1 3' untranslated region. 34874227 SLCC1 LncRNA Homo sapiens Colorectal Neoplasms CRC patients Regulation(HK2) qRT-PCR//RNA Pull-Down Further validation in two independent CRC cohorts confirmed the upregulation of lncSLCC1 in CRC tissues, and revealed that increased lncSLCC1 expression was associated with poor survival in CRC patients. Mechanistically, lncRNA-SLCC1 interacted with AHR and transcriptionally activated HK2 expression, the crucial enzyme in glucose metabolism, thereby driving the glycolysis pathway and accelerating CRC tumor growth. The functional assays revealed that lncSLCC1 induced glycolysis activation and tumor growth in CRC mediated by HK2. Further validation in two independent CRC cohorts confirmed the upregulation of lncSLCC1 in CRC tissues, and revealed that increased lncSLCC1 expression was associated with poor survival in CRC patients. Yes Mechanistically, lncRNA-SLCC1 interacted with AHR and transcriptionally activated HK2 expression, the crucial enzyme in glucose metabolism, thereby driving the glycolysis pathway and accelerating CRC tumor growth. 33602893 SLC9A3-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(microRNA-760 ) CCK8//qRT-PCR SLC9A3-AS1 was upregulated in NSCLC tissues and cell lines. Mechanistically, SLC9A3-AS1 acted as competing endogenous RNA for miR-760 to regulate NSCLC progression. In addition, rescue assay showed that downregulation of miR-760 could reverse the modulatory activity of SLC9A3-AS1 knockdown on NSCLC cells. SLC9A3-AS1 possessed a favorable ability in diagnosing NSCLC. A high level of SLC9A3-AS1 was associated with poor prognosis in NSCLC patients. Yes Functionally, SLC9A3-AS1 knockdown inhibited cell proliferation, migration, and invasion of NSCLC cells. 35300063 SLC8A1-AS1 LncRNA Homo sapiens Glioma glioma tissues Expression [highly expressed] In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Invasion Assay A validation experiment was conducted to confirm a high expression level of lncRNA SLC8A1-AS1 in glioma tissues. Yes Down-regulation of lncRNA SLC8A1-AS1 suppressed the proliferation, colony formation, migration, and invasion of glioma cells in vitro and in vivo. Moreover, lncRNA SLC8A1-AS1 silencing decreased the activity of the Wnt/β-catenin pathway and suppressed the epithelial to mesenchymal transition (EMT) in glioma cells. 34474120 SLC8A1-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary clinical PTC samples and PTC cell lines Interaction(FUS/Numbl axis) Western Blot//Wound Healing Assay//qPCR//CCK8//RIP//Cell Apoptosis Assay//Bioinformatics Analysis//Transwell Assay We observed that the expression of SLC8A1-AS1 was downregulated in clinical PTC samples and PTC cell lines compared to that in normal controls. Mechanistically, SLC8A1-AS1 maintained NUMB like endocytic adaptor protein (Numbl) mRNA stability by interacting with FUS RNA Binding Protein (FUS) in PTC cells. Depletion of Numbl reversed the inhibitory effect of SLC8A1-AS1 overexpression on PTC. Thus, we concluded that SLC8A1-AS1 suppresses PTC progression via the FUS/Numbl axis. Yes Cell counting kit (CCK)-8 assays demonstrated that the overexpression of SLC8A1-AS1 significantly reduced the proliferation of PTC cells. Consistently, apoptosis of PTC cells was enhanced by SLC8A1-AS1 overexpression. SLC8A1-AS1 overexpression attenuated the invasion and migration of PTC cells. 35599603 SLC7A11-AS1 LncRNA Homo sapiens Lung Neoplasms Lung cancer tissues regulation[Inhibiting miR-4775, Facilitating TRAIP ] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The up-regulated SLC7A11-AS1 in lung cancer patients was associated with metastasis and advanced tumor stage (P < 0.05). SLC7A11-AS1 promoted lung cancer development by enhancing TRAIP expression via suppressing miR-4775. The up-regulated SLC7A11-AS1 in lung cancer patients was associated with metastasis and advanced tumor stage (P < 0.05). Yes Silencing of SLC7A11-AS1 prominently inhibited H1299 and A549 cells proliferation, migration and invasion in vitro (P < 0.05). 32636648 SLC30A10 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cell lines regulation[miR-21c/APC axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay SLC30A10 was down-regulated in colorectal cancer tissues and cell lines, and its low expression was positively correlated with colorectal cancer progression and metastasis.Bioinformatics prediction and luciferase assay indicated that miR-21c is a direct target of SLC30A10, which plays the role of ceRNA in regulating colorectal cancer metastasis. In addition, miR-21c specifically targets APC gene. SLC30A10 was down-regulated in colorectal cancer tissues and cell lines, and its low expression was positively correlated with colorectal cancer progression and metastasis. Yes Functionally, SLC30A10 depletion promotes cell proliferation and migration in colorectal cancer cells, while SLC30A10 overexpression has the opposite effect. 32633358 SLC25A21-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell line regulation[miR-324-3p/IL-6 Axis] CCK8//qRT-PCR In this study, we found that SLC25A21-AS1 expression was increased in NPC tissues and cell line, and knockdown of SLC25A21-AS1 inhibited cell growth and MDR in NPC cell.Our findings demonstrated the role of SLC25A21-AS1/miR-324-3p/IL-6 axis in cell growth and MDR in NPC, which might be a potential prognostic and diagnostic marker in NPC patients and provide new insight into the molecular mechanism of MDR in NPC chemotherapy. Yes In this study, we found that SLC25A21-AS1 expression was increased in NPC tissues and cell line, and knockdown of SLC25A21-AS1 inhibited cell growth and MDR in NPC cell. 32547230 SLC2A1-DT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC samples regulation[ STAT3/FOXM1/GLUT1 pathway] ChIP//ISH//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the current study, we report that lncRNA SLC2A1-AS1 is frequently downregulated in HCC samples, as shown by quantitative real-time polymerase chain reaction analysis. Results from fluorescence in situ hybridization, ChIP and luciferase reporter assays demonstrated that SLC2A1-AS1 exerts its regulatory role on GLUT1 by competitively binding to transketolase and signal transducer and activator of transcription 3 (STAT3) and inhibits the transactivation of Forkhead box M1 (FOXM1) via STAT3, thus resulting in inactivation of the FOXM1/GLUT1 axis in HCC cells. SLC2A1-AS1 deletion is significantly associated with recurrence-free survival in HCC. Yes In vitro Cell Counting Kit-8, colony formation, transwell assays as well as in vivo tumorigenesis and metastasis assays showed that SLC2A1-AS1 overexpression significantly suppressed proliferation and metastasis in HCC through the transcriptional inhibition of GLUT1. 32174012 SLC26A4-AS1 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[NPTX1,NFKB1 ] qRT-PCR We determined that SLC26A4-AS1 was downregulated in human glioma tissues and cells. Taken together, we demonstrate that SLC26A4-AS1 promotes NPTX1 transcriptional activity by recruiting NFKB1 and thus exerting antiangiogenic effects on glioma cells. Yes Furthermore, overexpression of SLC26A4-AS1 or NPTX1 restrained the aggressiveness of glioma cells and their pro-angiogenic ability. 32255252 SLC26A4-AS1 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues interaction[DDX5] RNA Pull-Down//Western Blot//Co-IP//qRT-PCR//RIP//Transwell Assay//IF We found that lncRNA SLC26A4-AS1 was continuously, significantly down-regulated in normal tissues, thyroid cancer, and lymph node metastasis specimens. Intriguingly, SLC26A4-AS1 could simultaneously interact with DDX5 and the E3 ligase TRIM25, which promoting DDX5 degradation through the ubiquitin-proteasome pathway. We found that lncRNA SLC26A4-AS1 was continuously, significantly down-regulated in normal tissues, thyroid cancer, and lymph node metastasis specimens. Low SLC26A4-AS1 levels in tissues were significantly associated with poor prognosis of thyroid cancer patients. Yes LncRNA SLC26A4-AS1 markedly inhibited migration, invasion, and metastasis capability of cancer cells in vitro and in vivo. 32939012 SLC26A4 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(microRNA-15a) Transfection//qPCR//RIP//PCR//IP circSLC26A4 expression was upregulated in NSCLC tissues, and its high expression was significantly associated with poor survival of patients with NSCLC. The expression levels of circSLC26A4 were correlated with the expression levels of mature miR-15a, but not the expression levels of miR-15a precursor in NSCLC tissues. Yes A cell proliferation assay revealed that overexpression of circSLC26A4 reduced the inhibitory effects of overexpression of miR-15a on cell proliferation. 34429762 SLC25A5-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[miR-19a-3p/PTEN/PI3K/AKT signalling pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Microarray The results showed that the expressions of SLC25A5-AS1 in GC were significantly lower than that of adjacent normal tissues. Dual-luciferase reporter assay confirmed the direct interaction between SLC25A5-AS1 and miR-19a-3p, rescue experiment showed that co-transfection miR-19a-3p mimics and pcDNA-SLC25A5-AS1 could partially restore the ability of GC cell proliferation and the inhibition of cell apoptosis. The mechanism analyses further found that SLC25A5-AS1 might act as a competing endogenous RNAs (ceRNA), which was involved in the derepression of PTEN expression, a target gene of miR-19a-3p, and regulate malignant phenotype via PI3K/AKT signalling pathway in GC. Taken together, this study indicated that SLC25A5-AS1 was down-regulated in GC and functioned as a suppressor in the progression of GC. Moreover, it could act as a ceRNA to regulate cellular behaviours via miR-19a-3p/PTEN/PI3K/AKT signalling pathway. Thus, SLC25A5-AS1 might be served as a potential target for cancer therapeutics in GC. The results showed that the expressions of SLC25A5-AS1 in GC were significantly lower than that of adjacent normal tissues, which were significantly associated with tumour size, TNM stage and lymph node metastasis. Yes Moreover, SLC25A5-AS1 could inhibit GC cell proliferation, induce G1/G1 cell cycle arrest and cell apoptosis in vitro, as well as GC growth in vivo. 30793479 SLC25A25-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues regulation[EMT pathway] qRT-PCR Here, we identified one lncRNA HRCEG, whose expression was decreased in the gastric cancer tissues compared with adjacent normal tissues.These findings suggest that HRCEG might be regulated by HDAC1 to inhibit gastric cancer progress and metastatic capability via EMT pathway. Yes Overexpression of HRCEG significantly promoted cell apoptosis and inhibited cell proliferation. 31964588 SLC25A25-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines. Interaction(microRNA-195-5p/ITGA2 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay As compared with normal lung tissues, increased expression of SLC25A25-AS1 was demonstrated in NSCLC tissues using The Cancer Genome Atlas database.. In addition, SLC25A25-AS1 was overexpressed in both NSCLC tissues and cell lines.Mechanistically, SLC25A25-AS1 was demonstrated to be an miR-195-5p sponge in NSCLC cells. miR-195-5p mimics decreased ITGA2 expression in NSCLC cells by directly targeting ITGA2, and SLC25A25-AS1 interference decreased ITGA2 expression by sequestering miR-195-5p. High SLC25A25-AS1 expression was markedly associated with shorter overall survival time of patients with NSCLC. Yes SLC25A25-AS1 silencing impeded NSCLC cell proliferation and triggered apoptosis, while restricting cell migration and invasion. Tumour growth in vivo was also impaired by SLC25A25-AS1 silencing. 34055094 SFTA1P LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[PI3K-AKT signaling pathway ] qRT-PCR We found that the expression of SFTA1P was significantly downregulated in NSCLC tissues with high diagnostic value (AUC = 0.87), which was consistent with the results of TCGA and microarray data.Taken together, this work supported that SFTA1P may play a suppressing role in the tumorigenesis of NSCLC by modulating PI3K-AKT signaling pathway to influence cell cycle, which provides a potential and prospective biomarker for NSCLC. Yes Furthermore, the cell function results suggested that the overexpression of SFTA1P triggered cell cycle arrest in the S-phase (P < 0.05). 32825934 SLCO4A1-AS1 LncRNA Homo sapiens Melanoma melanoma cell Interaction(miR-1306-5p/PCGF2) qRT-PCR//Transfection Our study suggested that SLCO4A1-AS1 promoted the melanoma cell malignant behaviours via targeting miR-1306-5p/PCGF2, which might facilitate the discovery of novel biomarkers for melanoma treatment. Yes Additionally, proliferation, migration and invasion of melanoma cells were weakened but apoptosis was facilitated due to SLCO4A1-AS1 down-regulation. 35427425 hsa_circ_0132817 CircRNA Homo sapiens Neuroblastoma NB tissues and cells Regulation(miR-432-5p/NOL4L axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay//Transwell Assay In this paper, the levels of circ_0132817 and NOL4L were induced in NB tissues and cells, and miR-432-5p expression was on the contrary. MiR-432-5p was verified as a target of circ_0132817 and miR-432-5p could bind to NOL4L. The inhibitory effects of miR-432-5p overexpression on cell proliferation, migration, invasion and glycolysis could be reversed by circ_0132817 facilitation. The suppression of NOL4L knockdown on NB cells progression could be rescued by miR-432-5p inhibition. Besides, knockdown of circ_0132817 repressed tumor growth in vivo. Thus, we came to a conclusion that circ_0132817 promoted the tumorigenesis of NB cells by up-regulating NOL4L and acting as a sponge for miR-432-5p. Yes The inhibitory effects of miR-432-5p overexpression on cell proliferation, migration, invasion and glycolysis could be reversed by circ_0132817 facilitation. The suppression of NOL4L knockdown on NB cells progression could be rescued by miR-432-5p inhibition. Besides, knockdown of circ_0132817 repressed tumor growth in vivo. 33837793 circHIPK3 CircRNA Homo sapiens Diabetic Cardiomyopathies AC16 cells Regulation(PTEN ) Western Blot//Transfection//qRT-PCR//Cell Apoptosis Assay//ELISA The result showed that CircHIPK3 was downregulated in diabetes and further downregulated in DC. Across DC samples, the expression of circHIPK3 was inversely correlated with PTEN. In AC16 cells, overexpression of circHIPK3 decreased the expression levels of PTEN. Yes CircHIPK3 may suppress AC16 cell apoptosis induced by high glucose and inhibited the role of PTEN in cell apoptosis. Therefore, circHIPK3 may downregulate PTEN to protect cardiomyocytes from high glucose-induced cell apoptosis. 35200097 circTRPS1 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues or cell lines regulation[miR-124-3p/EZH2 axis-mediated stemness] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//IHC//Transwell Assay The result showed that circ-TRPS1 was upregulated significantly in high-grade PCa tissues or cell lines. In summary, data demonstrated that circ-TRPS1 suppressed PCa progression through functioning similar to a miR-124-3p sponge to enhance EZH2 expression and cancer stem-like cell differentiation. Yes Knockdown of circ-TRPS1 suppressed PCa proliferation and metastasis through targeting miR-124-3p/EZH2 axis-mediated stemness in PCa, which was validated by luciferase reporter assays. 33415005 SDPR-AS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction[p38 MAPK/ERK signals] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay SDPR-AS was lowly expressed in NSCLC tissues and cells, but had no changes in SCLC tissues and cells. Our findings indicate that SDPR-AS was lowly expressed in NSCLC cells and down-regulation of SDPR-AS may promote the malignant behaviors of NSCLC cells possible through regulating SDPR expression and involving in p38 MAPK/ERK signaling pathway. SDPR-AS may serve as a prospective target for NSCLC diagnosis and therapy. Yes Down-regulation of SDPR-AS enhanced the proliferation, migration and invasion and inhibited apoptosis of NSCLC cells (H522, H661 and H520). Overexpression of SDPR-AS exhibited opposite effects. 31352804 hsa_circ_0135889 CircRNA Homo sapiens Neuroblastoma NB cells Interaction(miR-127-5p/NEUROD1) In Vivo Experiment//RNA Pull-Down//Western Blot//qPCR//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//IHC//Transwell Assay " Circ_0135889 and neuronal differentiation 1 (NEUROD1) were upregulated whilst microRNA (miR)-127-5p, was downregulated in NB tumors and immortalized NB cells. Circ_0135889 was a sponge for miR-127-5p, and inhibition of miR-127-5p counteracted the inhibitory impact of circ_0135889 knockdown on the malignant behaviors of NB cells. Moreover, NEUROD1 was a direct target of miR-127-5p, and miR-127-5p exerted the anti-tumor role in NB cells by targeting NEUROD1. Furthermore, circ_0135889 regulated NEUROD1expression by sponging miR-127-5p. " Yes Silencing of circ_0135889 could suppress cell proliferation, migration and invasion, but enhance apoptosis rate of NB cells in vitro. More importantly, circ_0135889 depletion inhibited xenograft tumor growth of NB cells. 35772185 hsa_circ_0125803 CircRNA Homo sapiens Neuroblastoma neuroblastoma samples Interaction(miR-197-5p-E2F1 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We identified hsa_circ_0125803 (circ0125803) as an extremely upregulated circRNA in neuroblastoma samples. Our data demonstrated upregulation of circ0125803 promotes the neuroblastoma progression by blocking miR-197-5p and upregulating E2F1 expression. Yes Knockdown of circ0125803 significantly decreased the growth rate and invasion rate in neuroblastoma. 35358781 SDCBP-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(hnRNP K to destabilize β-catenin) RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//RIP//RNA-seq//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//IF SDCBP2-AS1 was significantly downregulated in GC tissues and predictive of poor patient prognosis. Mechanically, SDCBP2-AS1 physically bound to hnRNP K to repress SUMOylation of hnRNP K and facilitated ubiquitination of hnRNP K and β-catenin, thereby promoting the degradation of β-catenin in the cytoplasm. SDCBP2-AS1 was significantly downregulated in GC tissues and predictive of poor patient prognosis. Yes Silencing of SDCBP2-AS1 promoted the proliferation and migration of GC cells both in vitro and in vivo. 36209503 SDCBP2-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and OC cell lines (COC1, A2780, and SKOV3) Interaction(miR-100-5p) Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay  LncRNA SDCBP2-AS1 and EPDR1 levels were suppressed whilst miR-100-5p level was elevated in OC. Yes After upregulating lncRNA SDCBP2-AS1 or EPDR1, viability, migration, and invasion of OC cells were impaired, and apoptosis rate was increased. Downregulating EPDR1 or upregulating miR-100-5p partially mitigated upregulated lncRNA SDCBP2-AS1-induced impacts on the biological functions of OC cells.  34218800 circKIF2A CircRNA Homo sapiens Neuroblastoma 21 neuroblastoma tissues and cells Interaction( miR-377-3p/PRPS1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Invasion Assay//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//EdU Staining The expression levels of CircKIF2A and PRPS1 were increased and that of miR-377-3p were decreased in 21 neuroblastoma tissues and cells.Mechanically, circKIF2A could work as a sponge of miR-377-3p to enhance PRPS1 expression. CircKIF2A knockdown impedes cell proliferation, metastasis, and glycolysis partly by regulating the miR-377-3p/PRPS1 axis, suggesting that targeting circKIF2A can be a feasible therapeutic strategy for neuroblastoma. Yes Functionally, the silencing of circKIF2A inhibited cell proliferation, migration, invasion, and glycolysis, boosted apoptosis in neuroblastoma cells in vitro, and blocked the growth of subcutaneously transplanted tumors in nude mice. 35039981 circACAP2 CircRNA Homo sapiens Neuroblastoma neuroblastoma tissues and cell lines Interaction(neuroblastoma cells) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay The abundances of ACAP2 and HK2 were remarkedly increased in neuroblastoma tissues and cell lines. Yes silencing ACAP2 significantly constrained neuroblastoma cell migration, invasion, and glycolysis, and promoted apoptosis. Bioinformatics prediction, luciferase assay, and RNA pull-down assay consistently demonstrated that ACAP2 sponged miR-143-3p to downregulate its expression in neuroblastoma cells. 35070838 SEMA3B LncRNA Homo sapiens Glioblastoma glioblastoma cells Interaction(miR-195/cyclin D1) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//BrdU We observed downregulation of SEMA3B-AS1 in GBM. The expression of SEMA3B-AS1 was inversely correlated with the expression of cyclin D1 but positively correlated with the expression of miR-195. In GBM cells, overexpression of SEMA3B-AS1 and miR-195 caused reduced expression levels of cyclin D1. MiR-195 inhibitor reduced the effects of overexpression of SEMA3B-AS1 on the expression of cyclin D1. Moreover, overexpression of SEMA3B-AS1 increased the expression levels of miR-195. Yes Cell proliferation data showed that, SEMA3B-AS1 and miR-195 decreased cell proliferation, while overexpression of cyclin D1 increased GBM cell proliferation. In addition, miR-195 inhibitor inhibited the role of overexpression of SEMA3B-AS1 in cancer cell proliferation. 35287551 hsa_circ_0013401 CircRNA Homo sapiens Neuroblastoma NB tissues and cells Interaction( miR-195/PAK2) In Vivo Experiment//Transfection//Colony Formation Assay//CCK8//FISH//qRT-PCR//Flow Cytometry//IHC//Transwell Assay hsa_circ_0013401 was highly expressed, miR-195 was lowly expressed, and there was a negative correlation between hsa_circ_0013401 and miR-195 in NB. Luciferase reporter assays showed that miR-195 was a direct target of hsa_circ_0013401, and PAK2 was the downstream target gene of miR-195. Yes The inhibitory effects of hsa_circ_0013401 knockdown suppressed the proliferation, migration, and invasion and induced the apoptosis and autophagy of NB cells by targeting miR-195 to downregulate PAK2 expression. In vivo studies showed that hsa_circ_0013401 promotes tumor formation. 34853631 circPDE5A CircRNA Homo sapiens Neuroblastoma NB tissues and cells Interaction(miR-362-5p/NOL4L axis) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay Our results revealed that circPDE5A was up-regulated in NB tissues and cells. Moreover, circPDE5A directly targeted miR-362-5p by binding to miR-362-5p. CircPDE5A silencing impeded NB malignant progression in vitro through up-regulating miR-362-5p. Furthermore, NOL4L was a direct target of miR-362-5p, and NOL4L mediated the regulation of miR-362-5p on NB malignant progression in vitro. Additionally, circPDE5A functioned as a regulator of NOL4L expression via targeting miR-362-5p. Yes The silencing of circPDE5A suppressed NB cell proliferation, migration, invasion, and glycolysis in vitro and diminished tumour growth in vivo. 33635749 SCIRT LncRNA Homo sapiens Lung Neoplasms cancer cell exosomes Interaction(miR-665) qRT-PCR We further demonstrated that lncRNA SCIRT was also increased in cancer cell exosomes and may facilitate the exosomal loading of miR-665 with the help of hnRNPA1. Yes In addition, we found that miR-665 and SCIRT were significantly upregulated in tumor tissue and plasma of patients with lung cancer, and both of them showed increased expression in metastatic disease samples. 34349799 SCIRT LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Interaction(miR-221/lncRNA GAS5) qRT-PCR//RNA Pull-Down SCIRT and GAS5 were downregulated, while miR-221 was overexpressed in OSCC. CIRT was detected in both nucleus and cytoplasm and directly interacted with miR-221, while SCIRT overexpression failed to affect miR-221 expression. In addition, GAS5 expression was increased by SCIRT and decreased by miR-221. Yes Moreover, SCIRT suppressed the role of miR-221 in suppressing GAS5 expression and OSCC cell apoptosis. 34547134 SCIRT LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Expression(highly expressed) Western Blot//Transfection//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay//Transwell Assay LncRNA SCIRT was highly expressed in CC tissues and cells, and significantly linked with clinical/pathology-based characteristics of patients, including Federation Internationale of Gynecologie and Obstetrigue (FIGO) stage, tumor dimensions, and lymph-node metastasis. Western blotting analysis demonstrated that SCIRT knockdown upregulated e-cadherin and downregulated n-cadherin, vimentin, MMP-9, and MMP-2. Meanwhile, overexpressing SCIRT of lncRNA SCIRT had the opposite effect. LncRNA SCIRT was highly expressed in CC tissues and cells, and significantly linked with clinical/pathology-based characteristics of patients, including Federation Internationale of Gynecologie and Obstetrigue (FIGO) stage, tumor dimensions, and lymph-node metastasis. Yes SCIRT knockdown markedly reduced CC proliferative, colony forming, and invasive properties, while overexpressing SCIRT promoted the proliferative and invasive properties of CC.Western blotting analysis demonstrated that SCIRT knockdown upregulated e-cadherin and downregulated n-cadherin, vimentin, MMP-9, and MMP-2. Meanwhile, overexpressing SCIRT of lncRNA SCIRT had the opposite effect. Tumorigenic experiment showed that SCIRT knockdown could markedly reduce CC proliferative property the nude mouse. 35979035 SCIRT LncRNA Homo sapiens Atherosclerosis HAOSMCs Regulation(miR-146a) BrdU//qRT-PCR//Transfection//RNA Pull-Down SCIRT was downregulated by atherosclerosis, while miR-146a was upregulated by atherosclerosis. SCIRT was detected in both cytoplasm and nuclear samples, and it directly interacted with miR-146a. In HAOSMCs, overexpression of SCIRT and miR-146a did not affect the expression of each other. Interestingly, SCIRT suppressed the proliferation of HAOSMCs and reduced the enhancing effects of miR-146a on cell proliferation. Yes In HAOSMCs, overexpression of SCIRT and miR-146a did not affect the expression of each other. 34742341 SCHLAP1 LncRNA Homo sapiens Glioblastoma glioma tissue Regulation[NF-κB signaling] RNA Pull-Down//ISH//Co-IP//Colony Formation Assay//qRT-PCR//RIP//Luciferase Report Assay//IHC SChLAP1 was increased in primary GBM samples and cell lines. SChLAP1 was found to bind heterogeneous nuclear ribonucleoprotein L (HNRNPL), which stabilized the lncRNA and led to an enhanced interaction with the protein actinin alpha 4 (ACTN4). ACTN4 was also highly expressed in primary GBM samples and was associated with poorer overall survival in glioma patients. The SChLAP1-HNRNPL complex led to stabilization of ACTN4 through suppression of proteasomal degradation, which resulted in increased nuclear localization of the p65 subunit of NF-κB and activation of NF-κB signaling, a pathway associated with cancer development. Yes SChLAP1 was increased in primary GBM samples and cell lines, and knockdown of the lncRNA suppressed growth. 31492748 SCHLAP1 LncRNA Homo sapiens Triple Negative Breast Neoplasms 50 paired TNBC tissues and matched adjacent normal tissues Interaction(miR‑524‑5p/HMGA2 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Bioinformatics Analysis The present study determined that SChLAP1 was upregulated in TNBC tissues and was associated with the long‑distant lymph node metastasis of patients with TNBC. Bioinformatics analysis suggested that SChLAP1 acted as a sponge of microRNA (miR)‑524‑5p and negatively modulated the expression of miR‑524‑5p. An inverse correlation was also identified between the expression levels of SChLAP1 and miR‑524‑5p in TNBC tissues. The present study determined that SChLAP1 was upregulated in TNBC tissues and was associated with the long‑distant lymph node metastasis of patients with TNBC. Yes Knockdown of SChLAP1 significantly inhibited cell viability and colony formation, and triggered apoptosis of TNBC cells. 33846810 SEMA3B LncRNA Homo sapiens gastric cardia adenocarcinoma GCA tissues,cell lines Interaction[ZNF143 ] qRT-PCR//RNA Pull-Down//IHC//Western Blot Frequent downregulation of SEMA3B, SEMA3B-AS1, and miR-6872 was detected in GCA tissues and gastric cancer cells. ZNF143 might be the target gene of miR-6872-5p and miR-6872-5p functioning synergistically with SEMA3B to suppress cell invasion. Yes Overexpression of SEMA3B and SEMA3B-AS1 inhibited gastric cancer cell proliferation, migration, and invasion in vitro. 30656427 SEMA3B-AS1 LncRNA Homo sapiens gastric cardia adenocarcinoma GCA tissues,cell lines Interaction[MLL4] qRT-PCR Frequent downregulation of SEMA3B, SEMA3B-AS1, and miR-6872 was detected in GCA tissues and gastric cancer cells. SEMA3B-AS1 induced the expression of SEMA3B by interacting with MLL4. Yes Overexpression of SEMA3B and SEMA3B-AS1 inhibited gastric cancer cell proliferation, migration, and invasion in vitro. 30656427 SFTA1P LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines Interaction( Hippo-YAP/TAZ signaling) qRT-PCR//RNA Pull-Down//Western Blot Using non-small cell lung cancer (NSCLC) cell lines, we show that SFTA1P is transcriptionally activated by YAP/TAZ in a TEAD-dependent manner. Mechanistically, SFTA1P knockdown decreased TAZ protein abundance and consequently, the expression of YAP/TAZ transcriptional targets. Yes Functionally, knockdown of SFTA1P in NSCLC cell lines inhibited proliferation, induced programmed cell death, and compromised their tumorigenic potential. 34845189 circRANBP9 CircRNA Homo sapiens Polycystic Ovary Syndrome plasma of patients with PCOS Interaction(microRNA-136-5p/ XIAP axis) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay First, the circ_RANBP9 level was found to be increased in the plasma of patients with PCOS and ovarian granulosa cells (GCs) using Reverse Transcription-Quantitative Polymerase Chain Reaction (RT-qPCR). Furthermore, bioinformatics analysis showed that circ_RANBP9 and XIAP can be targeted by the microRNA, miR-136-5p. Yes In GCs, loss of circ_RANBP9 decelerated proliferation and accelerated apoptosis of KGN and COV434 cells, as determined by MTT assay, colony formation assay, and flow cytometry. 34546853 SFTA1P LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-4766-5p via PI3K/AKT/mTOR Signaling Pathway] qRT-PCR//Luciferase Report Assay//Western Blot SFTA1P was up-regulated in HCC tissues and cell lines. lncRNA SFTA1P could promote tumor development in HCC by down-regulating miR-4766-5p expression via PI3K/AKT/mTOR signaling pathway. It may be a potential therapeutic target for HCC. SFTA1P expression was closely related to tumor size, vascular invasion and TNM stage. Yes Knockdown of SFTA1P inhibited HCC cell viability, migration and invasion and promoted cell apoptosis. 33061455 SFTA1P LncRNA Homo sapiens Uterine Cervical Neoplasms tumor tissues and cells Interaction( SFTA1P-PTBP1-TPM4 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Migration Assay//qRT-PCR//Survival Analysis//RIP//RNA-seq//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay//Invasion Assay SFTA1P is upregulated in cervical tumor tissues and its high expression is associated with poor prognosis. Mechanistically, SFTA1P was shown to interact with polypyrimidine tract binding protein 1 (PTBP1) to regulate the stability of tropomyosin 4 (TPM4) mRNA, thereby resulting in malignant cell phenotypes. TPM4 knockdown could attenuate the suppression of cell progression induced by either SFTA1P or PTBP1 knockdown. SFTA1P is upregulated in cervical tumor tissues and its high expression is associated with poor prognosis. Yes Biologically, knockdown of SFTA1P inhibited the proliferation, migration, and invasion of cervical cancer cells in vitro, as well as tumorigenesis and metastasis in vivo. 36344495 SFTA1P LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cell and tissues Interaction(miR-4766-5p/LATS1/YAP pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR "SFTA1P was lowly expressed in LUAD, which was associated with the poor prognosis of patients with LUAD. MiR-4766-5p acted as an intermediate ""bridge"" for SFTA1P to regulate LATS1. " SFTA1P was lowly expressed in LUAD, which was associated with the poor prognosis of patients with LUAD. Yes Up-regulated SFTA1P prevented the metastasis of LUAD cells and the nuclear translocation of YAP. Hypoxia-induced exosomes stimulated LUAD cell metastasis, but inhibited the SFTA1P and LATS1/YAP axes. SFTA1P repressed xenograft growth and LUAD cell metastasis. 36283586 hsa_circ_0043532 CircRNA Homo sapiens Polycystic Ovary Syndrome GCs and KGN cells Interaction(miR-182/SGK3 axis ) Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//EdU Staining irc_0043532 was markedly elevated in PCOS granulosa cells (GCs) and KGN cells. Silencing of circ_0043532 suppressed cell proliferation and cell cycle process and promoted cell apoptosis in PCOS GCs and KGN cells. For mechanistic analysis, circ_0043532 was identified as a sponge of miR-182 and SGK3 was confirmed to be a target gene of miR-182. Inhibition of miR-182 rescued the impacts of circ_0043532 interference on PCOS GCs and KGN cell progression. Moreover, miR-182 overexpression suppressed cell proliferation and cell cycle process and promoted cell apoptosis in PCOS GCs and KGN cells by targeting SGK3. Yes For mechanistic analysis, circ_0043532 was identified as a sponge of miR-182 and SGK3 was confirmed to be a target gene of miR-182. Inhibition of miR-182 rescued the impacts of circ_0043532 interference on PCOS GCs and KGN cell progression. 34740363 SERPINE2 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[sponging miR-375 and modulating YWHAZ] RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//EdU Staining Circ-SERPINE2 and YWHAZ were upregulated, and miR-375 was downregulated in GC tissues and cells. Circ-SERPINE2 and YWHAZ targetedly bound to miR-375. Circ-SERPINE2 promoted cell proliferation and cell cycle progress and inhibited cell apoptosis by sponging miR-375 and regulating YWHAZ expression in vitro. Yes Circ-SERPINE2 repressed solid tumour growth through enhancing miR-375 expression and reducing YWHAZ expression in vivo. 31199037 SERPINE2 CircRNA Homo sapiens Glioblastoma glioblastoma cell lines and tissues Interaction(miR-361-3p/miR-324-5p/ BCL2) colony Formation Assay//RNA Pull-Down//Western Blot//Transfection//qPCR//RIP//Cell Apoptosis Assay//PCR//IP//Colony Formation Assay//IF In our study, we identified a novel upregulated circRNA, circSERPINE2, through analyzing circRNAs microarray data of glioblastoma from GEO datasets (GSE146463).Mechanistically, circSERPINE2 could directly sponge miR-324-5p and miR-361-3p. BCL2, known as a novel anti-apoptosis gene, is a target gene both of miR-324-5p and miR-361-3p. Yes Silencing circSERPINE2 inhibits glioblastoma proliferation in vivo and in vitro through cell counting kit-8 (CCK-8) assay, colony formation assay, flow cytometry analysis, and western blot analysis and xenograft tumor model. 34553034 SERPINB9P1 LncRNA Homo sapiens Ischemic Stroke patients with IS Mutation(rs375556 ) qRT-PCR//Genotyping We found that the SERPINB9P1 expression was significantly downregulated in patients with IS compared with that in healthy controls. After stratification by gender, the rs375556 polymorphism was significantly associated with susceptibility to female IS in the recessive model, and the significant association remained after adjusting for age. Yes After adjusting for gender and age, rs318429 was significantly associated with FPG and D-D levels, and rs375556 was significantly associated with INR and PTA levels in IS cases. Besides, the lncRNA SERPINB9P1 expressed downregulated in OGD/reoxygenation-treated human A172 cells. In conclusion, the lncRNA SERPINB9P1 may protect against cerebral ischemia-reperfusion injury and neurological impairment after IS. 34273050 circFURIN CircRNA Homo sapiens Polycystic Ovary Syndrome GCs Interaction(miR-195-5p/BCL2 axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay Circ-FURIN was upregulated in PCOS patients and granular cells (GCs). Knockdown of circ-FURIN inhibited cell proliferation and promoted apoptosis of KGN cells, along with the increased expression of caspase-3 and Bax and the decreased levels of p-PI3K. Gene ontology (GO) analysis indicated circ-FURIN is associated with apoptotic signaling pathway and cell death. Subsequently, BCL2 expression was elevated in patients with PCOS and positively regulated by circ-FURIN. Furthermore, circ-FURIN was served as a sponge of miR-195-5p to directly target to BCL2. The levels of miR-195-5p were reduced in PCOS and KGN cells. Knockdown of circ-FURIN decreased the expression of BCL2, which was abolished by miR-195-5p inhibitor. At last, rescue experiments revealed that overexpression of BCL2 reversed the effects of circ-FURIN knockdown on cell proliferation and apoptosis of KGN cells. Yes Knockdown of circ-FURIN inhibited cell proliferation and promoted apoptosis of KGN cells, along with the increased expression of caspase-3 and Bax and the decreased levels of p-PI3K. 34784951 circRHBG CircRNA Homo sapiens Polycystic Ovary Syndrome granular cells of PCOS patients Interaction(miR-515/SLC7A11 axis) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Microarray//EdU Staining CircRNA high-throughput chips and qRT-PCR verified that circRHBG was significantly upregulated in granular cells of PCOS patients. Luciferase reporter assays and Ago2-RIP detection showed that circRHBG competes with SLC7A11 to bind to miR-515-5p. Yes Knockdown of circRHBG inhibits KGN and SVOG cell proliferation. 34532485 SEMA3B-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[PTEN ] qRT-PCR//Western Blot We found that SEMA3B-AS1 was downregulated in HCC tissues compared with noncancer tissues and was not affected by hepatitis B virus (HBV) and hepatitis C virus (HCV) infections.Therefore, miR-718 may mediate the indirect interaction between lncRNA SEMA3B-AS1 and PTEN to regulate the proliferation of hepatocellular carcinoma cells. Yes SEMA3B-AS1 and PTEN overexpression resulted in a reduced proliferation rate of HCC cells 31251699 circPSMC3 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues regulation[ circPSMC3/miR-296-3p/PTEN axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//H&E Staining//EdU Staining In this study, we determined the abnormal reduction in circPSMC3 expression by comparing the ovarian tissue samples of PCOS patients and normal individuals. Collectively, we preliminarily characterized the role and possible insights of circPSMC3/miR-296-3p/PTEN axis in the proliferation and apoptosis of KGN cells. Yes In vitro functional experiments confirmed that circPSMC3 can inhibit cell proliferation and promote apoptosis by blocking the cell cycle in human-like granular tumour cell lines. 32808450 SENCR LncRNA Homo sapiens Aortic Aneurysm, Abdominal VSMCs & aortic tissues Expression(lower expressed) In Vivo Experiment//qRT-PCR//Transfection//Western Blot SENCR was decreased in AAA. Overexpression of SENCR inhibited AAA formation via inhibition of VSMC apoptosis and extracellular matrix degradation. Yes Overexpression of SENCR inhibited AAA formation via inhibition of VSMC apoptosis and extracellular matrix degradation. 32903173 SENCR LncRNA Homo sapiens Coronary Disease blood Expression[lower expressed] qRT-PCR The results showed that SENCR was downregulated in the peripheral blood of CHD, and negatively related to the Gensini score. Yes Overexpression of SENCR significantly inhibited HA-VSMCs proliferation, migration, and block cell cycle, while the knockdown of SENCR had the opposite effects. 32401347 circCTNNA1 CircRNA Homo sapiens Lymphoma, Mantle-Cell MCL patientsand cells Interaction(miR-34a) RNA Pull-Down//Transfection//qPCR//Cell Proliferation Assay//BrdU The results showed that circCTNNA1 was upregulated in MCL and high expression levels of circCTNNA1 predicted the poor survival of MCL patients. MiR-34a was downregulated in MCL and inversely correlated with circCTNNA1. CircCTNNA1 was predicted to interact with miR-34a, and the interaction between them was confirmed by RNA pull-down assay. Interestingly, overexpression of circCTNNA1 and miR-34a did not affect the expression of each other. The results showed that circCTNNA1 was upregulated in MCL and high expression levels of circCTNNA1 predicted the poor survival of MCL patients Yes Cell proliferation analysis showed that overexpression of circCTNNA1 reversed the inhibitory effects of overexpression of miR-34a on cell proliferation. 35865405 circCDYL CircRNA Homo sapiens Lymphoma, Mantle-Cell blood Expression[highly expressed] qRT-PCR CircCDYL was high expressed in the plasma of MCL patients. Yes Functionally, circCDYL knockdown inhibited MCL cell proliferation. 31819653 SEMA3B-AS1 LncRNA Homo sapiens Stomach Neoplasms PM tissues and cell line Interaction(SEMA3B-AS1/HMGB1/FBXW7 Axis) RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The mRNA expression level of SEMA3B-AS1 was downregulated in GC and PM tissues compared to normal stomach tissues; however, BGN was highly expressed at the mRNA level.Mechanistically, SEMA3B-AS1 could combine with HMGB1 to regulate the transcription of FBXW7, thus facilitating the ubiquitination of BGN. In conclusion, our study demonstrated that the SEMA3B-AS1/HMGB1/FBXW7 axis plays an inhibitory role in the PM of GC by regulating BGN protein ubiquitination. It also provides a new biological marker for the diagnosis and treatment of the PM of GC. SEMA3B-AS1 was closely related to PM and the overall survival (OS) of GC patients. Yes Functionally, the overexpression of SEMA3B-AS1 was related to GC progression, PM, and prognosis. 35273678 SEMA3B-AS1 LncRNA Homo sapiens Breast Neoplasms TNBC tissues and cells Interaction(SMAD3/lncRNA SEAS1/miR-3940-3p/KLLN axis) ChIP//Western Blot//CCK8//qRT-PCR//FISH//Flow Cytometry//RIP//RNA-seq//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay SEAS1 was downregulated in the triple-negative breast cancer (TNBC) tissues compared with the para-carcinoma tissues, which was associated with poor prognosis of TNBC patients. Bioinformatics analysis demonstrated that microRNA (miR)-3940-3p was a potential target of SEAS1. Mechanistically, RNA immunoprecipitation (RIP) and luciferase reporter assays confirmed that lncRNA SEMA3B-AS1 acted as sponge for miR-3940-3p, preventing the degradation of its target gene KLLN, which acts as a tumor-inhibiter in TNBC. Moreover, RNA pulldown, mass spectrometry, ChIP, and luciferase reporter assays confirmed that SMAD3 directly interacted with the promoter of SEAS1 and suppressed its transcription, thereby promoting TNBC progression. SEAS1 was downregulated in the triple-negative breast cancer (TNBC) tissues compared with the para-carcinoma tissues, which was associated with poor prognosis of TNBC patients. The clinical samples of TNBC confirmed SEAS1 was correlated inversely with lymphatic and distant metastasis. Yes We demonstrated that SEAS1 knockdown significantly increased the proliferation, migration, and invasion of TNBC cell lines, whereas SEAS1 overexpression reversed these effects. 36123344 SEMA3B-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues ,cell lines Expression[lower expressed] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//ChIP Frequent downregulation of SEMA3B and SEMA3B-AS1 was detected in esophageal cancer cells and ESCC tissues, SEMA3B and SEMA3B-AS1 shared the same CpG island in the promoter region and the expression of both genes might be regulated by the promoter methylation status. Furthermore, transcription factor Sp1 activated SEMA3B or SEMA3B-AS1 transcription and the promoter hypermethylation of SEMA3B and SEMA3B-AS1 influenced Sp1 binding ability. Moreover, over-expression of SEMA3B and SEMA3B-AS1 suppressed the viability and invasion of esophageal cancer cells in vitro. SEMA3B-AS1 influenced the protein expression of SEMA3B. SEMA3B or SEMA3B-AS1 expression and promoter methylation status were correlated with ESCC patients' survival. the expression level of SEMA3B and SEMA3B-AS1 in ESCC tissues was correlated with TNM stage and lymph node metastasis. Yes Moreover, over-expression of SEMA3B and SEMA3B-AS1 suppressed the viability and invasion of esophageal cancer cells in vitro. 30915595 SLCO4A1-AS1 LncRNA Homo sapiens Precursor Cell Lymphoblastic Leukemia-Lymphoma ALL tissues and cell lines Interaction(miR-876-3p/RBBP6 axis) RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining SLCO4A1-AS1 was upregulated in ALL tissues and cell lines. Our result confirmed that SLCO4A1-AS1 acted as a ceRNA by sponging microRNA 876-3p (miR-876-3p) to upregulate retinoblastoma binding protein 6 (RBBP6) expression in ALL cells. Moreover, SLCO4A1-AS1 activated the JNK signaling pathway by upregulating RBBP6. Yes We found that suppression of SLCO4A1-AS1 suppressed ALL cell proliferation and facilitated cell apoptosis. 33683013 SLCO4A1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-223-3p/IKKα/NF-κB signaling] qRT-PCR qRT-PCR revealed that SLCO4A1-AS1 level was upregulated in NSCLC. In conclusion, SLCO4A1-AS1 drove NSCLC progression by activating NF-κB signaling pathway via sponging miR-223-3p to enhance IKKα expression. Yes Function assays manifested that silence of SLCO4A1-AS1 attenuated NSCLC cell proliferation, migration and invasion but promoted NSCLC cell apoptosis. 32687454 circTBC1D4 CircRNA Homo sapiens Neuroblastoma Five paired neuroblastoma tumor and adjacent normal fetal adrenal medulla samples Expression(lower expressed) qRT-PCR//circRNA-seq//migration assay//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis A total of 4704 differentially expressed circRNAs were found, including 2462 up-regulated and 2242 down-regulated circRNAs. According to our previous studies, the predicted target circRNAs of miR-21 involved in tumorigenic signaling pathways were selected, including circRNA-TBC1D4, circRNA-NAALAD2 and circRNA-TGFBR3. These circRNAs were associated with clinical features, and the circRNA expression was significantly lower (P < 0.05) in the NB tissues than in normal adrenal tissues. Yes Overexpression of circRNA-TBC1D4 promotes NB cell migration, but not proliferation and colony-formation in vitro.Besides that, xenograft analysis showed that circLDLR knockdown suppressed tumor growth in vivo via regulating LMO4 and miR-637. 34093041 Snhg1 LncRNA Mus musculus Epilepsy EP tissues,cell line regulation[miR-181a/BCL-2 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay SNHG1 expression was down-regulated in EP tissues and kainic acid (KA)-induced CTX-TNA2 cells. SNHG1 alleviated the progression of EP by modulating the miR-181a/BCL-2 axis in vitro, thus SNHG1 could act as a possible therapeutic target for treating EP. Yes Both the up-regulation of miR-181a and down-regulation of BCL-2 reversed the inhibiting effects of SNHG1 on apoptosis and inflammatory response of KA-induced CTX-TNA2 cells, and the promoting effect upon cell viability. 33359246 SNHG1 LncRNA Homo sapiens oral cavity cancer regulation[miR-421/HMGB2 axis] qRT-PCR In this research, we found that lncRNA SNHG1 was up-regulated in oral cancer. Then we revealed a new mechanism that lncRNA SNHG1 regulated the growth of oral cancer via controlling the miR-421/HMGB2 axis, which provided new therapy for patients with oral cancer. Yes Knockdown of lncRNA SNHG1 would inhibit the proliferation of oral cancer cells. 34174971 SNHG1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissue and cells Expression[highly expressed] CCK8//qRT-PCR We found that SNHG1 was overexpressed in OSCC tissue and cells and was associated with OSCC progression. Yes In addition, knockdown of SNHG1 suppressed cell proliferation in vitro and in vivo. 33376352 SNHG1 LncRNA Homo sapiens Stomach Neoplasms GC tumor tissues Interaction(SOCS2/JAK2/STAT pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//RIP//FISH//RNA-seq//Cell Proliferation Assay//Invasion Assay//Transwell Assay In this study, we investigated the clinical significance and function of lncRNA SNHG1 in GC. SNHG1 was significantly downregulated in GC tumor tissues compared with adjacent noncancerous tissues. Mechanically, SNHG1 was found interacted with ILF3, NONO and SFPQ. RNA-seq combined with bioinformatic analysis identified a serial of downstream genes of SNHG1, including SOCS2, LOXL2, LTBP3, LTBP4. Yes Overexpression of SNHG1 in BGC-823 cells remarkably inhibited not only cell proliferation, migration, invasion in vitro, but also tumorigenesis and lung metastasis in the chick embryo chorioallantoic membrane (CAM) assay in vivo. Conversely, inhibition of SNHG1 by transfection of siRNA in AGS cells resulted in opposite phenotype changes. 34179518 SNHG1 LncRNA Homo sapiens Arthritis, Rheumatoid RA-FLSs Interaction(PTBP1 ) RNA Pull-Down//Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//RIP//Cell Cycle Assay//Invasion Assay//IF Here, we found that lncRNA small nucleolar RNA host gene 1 (SNHG1) is up-regulated in RA-FLSs compared with FLSs from trauma arthritis and osteoarthritis patients. Furthermore, the regulation mechanism depends on the interaction between SNHG1 and polypyridine tract-binding protein 1 (PTBP1). This interaction influences PTBP1 expression that participates in the regulation of RA-FLSs biological behaviors. Yes The results suggest that SNHG1 in RA-FLSs helps to sustain the cellular functions of proliferation, migration and invasion. 33218941 circZNF91 CircRNA Homo sapiens Leukemia, Lymphocytic, Chronic, B-Cell CLL samples and cells Interaction(miR-1283/WEE1 Axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//EdU Staining circZNF91 was upregulated in CLL samples. circZNF91 could sponge miR-1283 to suppress its activity, which in turn upregulated WEE1 expression. Silencing circ-TTBK2 reduced WEE1 expression, while the inhibitor of miR-1283 enhanced WEE1 expression. The miR-1283/WEE1 axis mediated the effects of circZNF91 on cell proliferation and apoptosis, as well as induced cell cycle regulation. Yes Silencing circZNF91 attenuated CLL cell proliferation and induced apoptosis and cell cycle arrest. 35572733 SNHG1 LncRNA Homo sapiens oral squamous cell carcinoma OSCC samples and cells Interaction(SNHG1/miR-145-5p/KLF5 Axis) Migration Assay//Transection//qRT-PCR//CCK8//Luciferase Report Assay//EdU Staining//Transwell Assay SNHG1 was abnormally upregulated in OSCC samples and linked to a poor prognosis of OSCC patients. miR-145-5p was a key downstream target inducing the oncogenic role of SNHG1 in the OSCC process with KLF5 as its downstream gene. SNHG1/miR-145-5p/KLF1 axis is responsible for driving the malignant process of OSCC. SNHG1 was abnormally upregulated in OSCC samples and linked to a poor prognosis of OSCC patients. Yes Serving as an oncogene, SNHG1 strengthened proliferative and migratory functions of Tca8113 and CAL-27 cells. 35281530 Snhg1 LncRNA Mus musculus Parkinson Disease brain tissue,cell line Regulation[miR-221/222 /p27/mTOR pathway ] Western Blot//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//IHC We observed that SNHG1 expression was gradually upregulated in PD cellular and animal models. In conclusion, these results demonstrated that downregulation of SNHG1 attenuated MPP-induced decreases in LC3-II (an autophagic marker) levels and cytotoxicity through the miR-221/222/p27/mTOR pathway, suggesting that SNHG1 may be a therapeutic target for neuroprotection and disease treatment in PD. ++ Yes Furthermore, silencing SNHG1 promoted autophagy and prevented MPP-induced cell death, similar to the overexpression of the miR-221/222 cluster. 31499060 Snhg1 LncRNA Mus musculus Neuralgia spinal regulation[regulating CDK4 level] qRT-PCR//ELISA//Luciferase Report Assay//RIP SNHG1 was upregulated in rats undergoing SNL.SNHG1 induced NP by directly regulating CDK4 level. Yes Knockdown of SNHG1 alleviated the development of NP and overexpression of SNHG1 was capable of inducing NP symptoms in uninjured rats. 33336721 Snhg1 LncRNA Mus musculus Epilepsy hippocampus tissue regulation[miR-154-5p/TLR5 axis] Tunel//qRT-PCR//Luciferase Report Assay//H&E Staining//ChIP Elevated SNHG1 and decreased miR-154-5p were observed in both in vivo mouse model and in vitro cell model of epilepsy. In summary, SP1 transcriptionally activated-SNHG1 contributes to the development of epilepsy via directly regulating miR-154-5p/TLR5 axis, which provides novel targets in treatment of epilepsy. Yes Knockdown of SNHG1 or transfection with miR-154-5p mimics significantly ameliorated Mg2+ free-induced neuronal injury in SH-SY5Y cells. 33096314 SNHG1 LncRNA Homo sapiens gallbladder carcinoma GBC tissues and cells Interaction(miR-194-5p/ LIF and PDGFA) Other High expression of SNHG1 was observed in both GBC tissues and cells, and it was associated with tumor sizes. MiR-194-5p could competitively bind with SNHG1 and was low-expressed in GBC, revealing the negative correlation between SNHG1 and miR-194-5p. Downregulated miR-194-5p reversed the effects of SNHG1 silencing on viability, proliferation, invasion and EMT-related marker expressions in GBC cells. Additionally, LIF and PDGFA were the target genes of miR-194-5p. High expression of SNHG1 was observed in both GBC tissues and cells, and it was associated with tumor sizes. Yes ShSNHG1 inhibited SNHG1 expression and retarded the viability, proliferation and invasion of GBC cells, accompanied with downregulated N-Cadherin and Vimentin yet upregulated E-Cadherin. 36261179 Snhg1 LncRNA Mus musculus Abortion, Spontaneous trophoblast cells, RSA mice Interaction(microRNA-183-5p/ZEB2 axis) Western Blot//Transfection//Wound Healing Assay//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray//EdU Staining//Transwell Assay Microarray analysis was applied in RSA mice, and SNHG1 was identified as a significantly downregulated lncRNA. Mechanistically, SNHG1 bound to miR-183-5p in trophoblast cells. Moreover, miR-183-5p directly targeted ZEB2. Rescue experiment showed that ZEB2 silencing reversed the ameliorative effect of SNHG1 on pregnancy outcome and the promotion of trophoblast activity in RSA mice by impaired the Wnt/β-catenin pathway. Yes SNHG1 improved pregnancy outcome and reduced embryo resorption in RSA mice. Trophoblast cell proliferation, apoptosis, migration, and invasion were investigated by CCK8, EdU, TUNEL, wound healing, and Transwell assays. SNHG1 promoted proliferation, migration, and invasion of trophoblast cells, and reduced apoptosis. 35121558 SNGH3 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cell lines Expression [highly expressed] qRT-PCR//ELISA LncRNA SNGH3 (small nucleolar RNA host gene 3) is highly expressed in numerous forms of cancer, serving as an oncogene in cancer progression. Herein, the findings exhibited upregulation of SNGH3 in bladder cancer tissues, along with the cell lines. Furthermore, overexpressed SNGH3 was positively linked to the TNM stage, as well as the histological grade of bladder cancer. Yes Moreover, the silencing of SNGH3, using CRISPR-dCas9, suppressed cell growth along with migration, but elevated bladder cancer cell apoptosis. 33859998 SNG16 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[miR-302a-3p/FGF19 axis] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//Western Blot Here, we showed that SNG16 was up-regulated and associated with poor prognosis in HCC.Moreover, our result indicated that SNHG16/miR-302a-3p axis regulated the expression of FGF19 in liver cancer cells. Finally, we investigated the biological function of SNHG16 in HCC and showed that SNHG16 promoted liver cancer cells proliferation via the SNHG16/miR-302a-3p/FGF19 axis. Yes Finally, we investigated the biological function of SNHG16 in HCC and showed that SNHG16 promoted liver cancer cells proliferation via the SNHG16/miR-302a-3p/FGF19 axis. 30784284 SND1-IT1 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues Interaction(miR-1245b-5p/DDX54/USP3/SNAIL1) RNA Pull-Down//Western Blot//Wound Healing Assay//Co-IP//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Long non-coding RNA (lncRNA) SND1 intronic transcript 1 (SND1-IT1) is highly expressed in exosomes secreted by GC cells. SND1-IT1 was verified to bind to microRNA-1245b-5p (miR-1245b-5p) through competitive adsorption to promote ubiquitin specific protease 3 (USP3) messenger RNA (mRNA) expression. SND1-IT1 was validated to recruit DEAD-box helicase 54 (DDX54) to promote USP3 mRNA stability. SND1-IT1 induces malignant transformation of GES-1 cells through USP3. USP3 mediates the deubiquitination of snail family transcriptional repressor 1 (SNAIL1). Yes Exosome-mediated lncRNA SND1-IT1 from GC cells enhances malignant transformation of GES-1 cells via up-regulating SNAIL1. 35739527 SND1-IT1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells. Interaction(SND1-IT1/miR-124/COL4A1 axis ) CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay LncRNA SND1-IT1 was upregulated in GC tissues and cells. LncRNA SND1-IT1 participated in TGF-β1-stimulated EMT in GC by sponging miR-124. MiR-124 attenuated TGF-β1-stimulated EMT in GC by targeting COL4A1. Yes TGF-β1-stimulated EMT and regulated lncRNA SND1-IT1, miR-124, and COL4A1 expressions in HGC-27 cells. LncRNA SND1-IT1 knockdown tempered HGC-27 cell viability, migration and invasion. 35184134 circSOS2 CircRNA Homo sapiens cervical squamous cell carcinoma SCC tissues and cells Interaction(miR-543/FNDC3B axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircSOS2 was highly expressed in SCC tissues and cells; besides, its expression level was closely associated with poor prognosis. Loss-of-functional experiments revealed that suppression of circSOS2 repressed proliferation, cell cycle process, migration, invasion, and glycolysis while induced apoptosis in SCC cells, which was overturned by inhibition of miR-543. CircSOS2 was highly expressed in SCC tissues and cells; besides, its expression level was closely associated with poor prognosis. Yes Loss-of-functional experiments revealed that suppression of circSOS2 repressed proliferation, cell cycle process, migration, invasion, and glycolysis while induced apoptosis in SCC cells, which was overturned by inhibition of miR-543. 34023283 SND1-IT1 LncRNA Homo sapiens Retinoblastoma RB specimens and cells Interaction(miR-132-3p/SMAD2 axis) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We observed that SND1-IT1 was highly expressed in both RB specimens and cells, and associated with poorer prognosis of RB patients.MiR-132-3p was predicted to interact with SND1-IT1. RT-qPCR and dual-luciferase reporter assays verified the regulation of miR-132-3p by SND1-IT1 in RB cells. In addition, SND1-IT1 enhanced the expression of SMAD2 by sponging miR-132-3p. Yes Functional investigation revealed that downregulation of SND1-IT1 suppressed RB cell proliferation, migration and invasion in vitro and restrained RB tumorigenesis in vivo. 34969359 hsa_circ_0065898 CircRNA Homo sapiens cervical squamous cell carcinoma CSCC cell lines Expression(highly expressed) CCK8//qRT-PCR//Transwell Assay Hsa_circ_0065898 was significantly overexpressed in the CSCC cell lines. Hsa_circ_0065898 facilitated cell proliferation, migration, and invasion in CSCC. Yes Hsa_circ_0065898 was significantly overexpressed in the CSCC cell lines. Hsa_circ_0065898 facilitated cell proliferation, migration, and invasion in CSCC. 35116238 SNHG1 LncRNA Homo sapiens Epilepsy EP tissues Interaction(miR-181a/BCL-2 axis ) In Vivo Experiment//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//ELISA SNHG1 expression was down-regulated in EP tissues and kainic acid (KA)-induced CTX-TNA2 cells. In addition, we confirmed that SNHG1 targeted miR-181a, whereas BCL-2 was a target gene of miR-181a. Negative correlations between SNHG1 and miR-181a, as well as miR-181a and BCL-2 were exhibited. Yes The apoptosis and release of inflammatory factors (TNF-α, IL-1β, IL-6, and COX-2) in KA-induced CTX-TNA2 cells were suppressed by SNHG1 overexpression and promoted by miR-181a up-regulation. 33359246 SNHG1 LncRNA Homo sapiens Meningioma cell lines Regulation[Wnt signaling pathway] qRT-PCR In this work, it was discovered that SNHG1 was overexpressed in meningioma cell lines.Then mechanism experiments demonstrated that SNHG1 functioned as the role of sponging miR-556-5p and negatively regulated miR-556-5p expression. Moreover, it was verified that TCF12 is the direct downstream target of miR-556-5p. Furthermore, SNHG1/miR-556-5p/TCF12 axis promoted cell proliferation and suppressed cell apoptosis in meningioma via activating the Wnt signaling pathway. In the end, it was confirmed that TCF12 expression was positively regulated by SNHG1, and TCF12 could promote transcription of SNHG1 through binding with the promoter region of SNHG1. In conclusion, the SNHG1/miR-556-5p/TCF12 feedback loop promotes the tumorigenesis of meningioma through the Wnt signaling pathway. Yes SNHG1 deficiency restrained cell growth as well as accelerated apoptosis. 31692066 snaR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck blood Interaction[TGF-β1] qRT-PCR In the present study, we found that plasma levels of snaR were upregulated in patients with laryngeal squamous cell carcinoma (LSCC) than in healthy controls.Therefore, overexpression of lncRNA snaR is correlated with progression and predicts poor survival of LSCC and the mechanism of its actions is likely related to TGF-β1. Follow-up study showed that high plasma levels of snaR were correlated with poor overall survival. Yes snaR overexpression and exogenous TGF-β1 treatment promoted LSCC cell proliferation, migration, and invasion. 30506952 SNHG1 LncRNA Homo sapiens Prostatic Neoplasms cancer tissues regulation[miR-195-5p ] qRT-PCR SNHG1 was enhanced in PC, while miR-195-5p was decreased (p<0.05). SNHG1 can mediate the proliferation, invasion and EMT of PC by regulating miR-195-5p expression. Yes After transfection of DU-145 and PC-3, it was found that silence of SNHG1 or overexpression of miR-195-5p could evidently inhibit the proliferation and invasion, increase the apoptosis (p<0.05). 33090391 SNHG1 LncRNA Homo sapiens Pancreatic Neoplasms PCa tissues,cell lines Interaction[miR-195] qRT-PCR//Western Blot The results demonstrated that the expression levels of SNHG1 were increased in PCa cell lines and human tissue samples.We further confirmed that, in PCa cells, SNHG1 can negatively regulate miR-195 expression by acting as a ceRNA, and Cyclin D1 is a direct target of miR-195. Overexpression of miR-195 abrogated the oncogenic role of SNHG1 in PCa cells. High SNHG1 expression was notably correlated with adverse characteristics and poor survival of PCa patients. Yes Knockdown of SNHG1 sExpression[up-expression]pressed PCa cell proliferation in vitro and PCa tumor growth in vivo, and these effects might be associated with the induction of cell cycle arrest. 31933880 SNHG1 LncRNA Homo sapiens Pancreatic Neoplasms cell lines Regulation[Notch-1 signaling pathway ] Western Blot//Wound Healing Assay//qPCR//MTT//Transwell Assay SNHG1 was significantly upregulated in PC cells.Furthermore, SNHG1 knockdown inhibited the activation of the Notch-1 signaling pathway and inhibited the expression of N-cadherin, Hes1, Vimentin, Notch-1. The inhabitation was reversed when Notch-1 was overexpressed in si-SNHG1 cells. Yes Knockdown of SNHG1 could obviously suppress cell proliferation, invasion, and migration. 30520072 SNHG1 LncRNA Homo sapiens Pancreatic Neoplasms PC cells Interaction(miR-497/FGFR1) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Downregulation of SNHG1 blocked cell proliferation, migration and invasion, and induced apoptosis in vitro, while also inhibiting the EMT, shown by changes in the biomarkers E-cadherin, N-cadherin, and Vimentin. The opposite results were observed on upregulation of SNHG1. In vivo experiments showed that downregulation of SNHG1 inhibited tumor development in nude mice.Furthermore, experiments investigating the regulatory mechanism of SNHG1 indicated that SNHG1 acted as a competitive endogenous RNA, positively regulating the expression of fibroblast growth factor receptor 1 (FGFR1) through sponging miR-497. Rescue experiments demonstrated that the effects of SNHG1 downregulation on PC cells were attenuated when simultaneously inhibiting the levels of miR-497. Yes Downregulation of SNHG1 blocked cell proliferation, migration and invasion, and induced apoptosis in vitro, while also inhibiting the EMT, shown by changes in the biomarkers E-cadherin, N-cadherin, and Vimentin. The opposite results were observed on upregulation of SNHG1. In vivo experiments showed that downregulation of SNHG1 inhibited tumor development in nude mice. 35141164 hsa_circ_0007331 CircRNA Homo sapiens Endometriosis ectopic endometrial cells regulation[miR-200c-3p/HiF-1α axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay In this study, we identified aberrant high expression of circ_0007331 in ectopic endometrial cells by comparing the endometrial samples from patients with and without endometriosis. Collectively, we preliminarily characterized the role and possible insights of circ_0007331/miR-200c-3p/HIF-1α axis in the proliferation and invasion of ectopic endometrial cells. Yes Further functional experiments revealed that circ_0007331 knock-down effectively suppressed the viability, proliferation and invasive capacity of ectopic endometrial cells. 32960511 SNHG1 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues interaction[CDKN1A ] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//ChIP Herein, we have figured out that lncRNA SNHG1, with substantially enhanced expression in CCA, is capable of acting as the oncogenic molecule of CCA. In a mechanistic manner, we also showed that SNHG1 bound to the histone methyltransferase enhancer of the zeste homolog 2 (EZH2, which is regarded as the catalytic subunit of the polycomb repressive complex 2 (PRC2), which is an extremely conserved protein complex regulating gene expression with the help of methylating lysine 27 on histone H3), specifying the histone alteration pattern on the target genes, including CDKN1A, and, as a result, altered the CCA cell biology. Yes As revealed by our data, SNHG1 knockdown extensively inhibited CCA cell migration as well as proliferation in vitro and in vivo. 29970899 SNHG1 LncRNA Homo sapiens Cholangiocarcinoma cell lines Interaction[TLR4/NF-κB Pathway] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay In this study, the SNHG1 levels were boosted in CCA cell lines.The data also demonstrated that miR-140 could act as a target of SNHG1 in CCA and inhibited CCA cell proliferation and invasion, whereas the inhibition effects were relieved by overexpression of SNHG1. In addition, Toll-like receptor 4 (TLR4), an NF-κB-activating signal, was identified to be a target of miR-140. SNHG1, as a competing endogenous RNA (ceRNA) for miR-140, enhanced TLR4 expression and activated NF-κB signaling, thereby regulating growth and tumorigenesis in CCA. Animal experiments further confirmed this conclusion. Collectively, these findings not only uncovered a key role of SNHG1/miR-140/TLR4/NF-κB signaling axis in CCA tumorigenesis and progression but also denoted the probable utilization of SNHG1 as a therapeutic target for CCA. Yes In this study, the SNHG1 levels were boosted in CCA cell lines, and knockdown of SNHG1 repressed CCA cell proliferation and invasion in vitro. 30764893 SNHG1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissue and cells regulation[Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways ] RNA Pull-Down//Transwell Assay//qRT-PCR//MTT//Colony Formation Assay//IF We found that SNHG1 and EZH2 were up-regulated in PCa tissue and cells.This study reveals that lncRNA-SNHG1 regulates Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways via EZH2 gene to affect proliferation, apoptosis and autophagy of PCa cells. Yes The proliferation, colony formation, migration and invasion of LNCaP and PC3 cells were significantly reduced with the interference with SNHG1or EZH2 compared with the control group. 33194612 SNHG1 LncRNA Homo sapiens Prostatic Neoplasms PCa tumor tissues Expression[highly expressed] qRT-PCR//MTT//Tunel The SNHG1 expression was significantly upregulated in PCa tumor tissues compared with paired adjacent non-cancerous tissues. The SNHG1 expression was obviously associated with the TNM stage, Gleason Score, lymph node invasion, and long-term metastasis mortality rate. Yes Silencing of SNHG1 inhibited cell proliferation and promoted apoptosis in PC3 and DU145 PCa cell lines in vitro, while overexpression of SNHG1 led to opposite results. 33154308 SNHG1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues and cells Interaction(miR-383-5p) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Transwell Assay In this study, we found the level of SNHG1 was significantly upregulated in prostate cancer tissues and cells. MiR-383-5p was identified to be a target of SNHG1 by bioinformatics analysis, dual-luciferase reporter assay, RNA immunoprecipitation assay and RNA pull-down assay. MiR-383-5p was significantly downregulated in prostate cancer tissues and cells. Yes Knockdown of SNHG1 significantly suppressed proliferation, migration and invasion and promoted cell apoptosis in prostate cancer cells. In addition, knockdown of SNHG1 significantly downregulated proliferating cell nuclear antigen and upregulated cleaved caspase-3. 33470616 SNHG1 LncRNA Homo sapiens Myocardial Reperfusion Injury H/R-induced AC16 cells Interaction(miR‑450b‑5p/IGF1 axis ) Western Blot//Transfection//Tunel//qRT-PCR//MTT//Luciferase Report Assay lncRNA SNHG1 expression was significantly downregulated in H/R-induced AC16 cells. lncRNA SNHG1 overexpression significantly inhibited apoptosis and decreased oxidative stress levels in H/R‑induced AC16 cells, which was mediated via regulation of the miR‑450b‑5p/IGF1 axis and activation of the PI3K/Akt signaling pathway. Yes lncRNA SNHG1 overexpression significantly inhibited apoptosis and decreased oxidative stress levels in H/R?induced AC16 cells, which was mediated via regulation of the miR?450b?5p/IGF1 axis and activation of the PI3K/Akt signaling pathway. 35315499 SNHG1 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC cells Interaction(SNHG1/miR-194-5p/MTFR1 Axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Transwell Assay Importantly, SNHG1 promoted EMT, invasion and migration of TSCC cells by upregulating MTFR1. SNHG1/miR-194-5p/MTFR1 axis promotes TGFβ1-induced EMT, migration and invasion of cells in TSCC, which could be potential targets for treating TSCC patients. Yes Importantly, SNHG1 promoted EMT, invasion and migration of TSCC cells by upregulating MTFR1. SNHG1/miR-194-5p/MTFR1 axis promotes TGFβ1-induced EMT, migration and invasion of cells in TSCC, which could be potential targets for treating TSCC patients. 35107755 SNHG1 LncRNA Homo sapiens Liver Neoplasms LC tissues, cell lines Interaction[inhibiting p53 expression via binding to DNMT1] ChIP//Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay NHG1 expression was higher in LC tissues than that of paracancerous tissues. LC patients with stage III-IV presented higher expression level of SNHG1 than those with stage I-II.Similarly, SNHG1 was highly expressed in LC cells than that of normal liver cells. RIP and ChIP results demonstrated that SNHG1 could bind to DNMT1 and inhibit p53 expression. Overexpression of p53 partially reversed the inhibitory effects of SNHG1 on proliferative and invasive abilities of LC cells. LC patients with stage III-IV presented higher expression level of SNHG1 than those with stage I-II. Yes SNHG1 knockdown inhibited the proliferative and invasive abilities, and arrested the cell cycle in the G0/G1 phase of SMMC-7721 and SK-HEP-1 cells. 31002127 SNHG1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma esophageal squamous cell cancer tissues regulation[miR-204/HOXC8 Axis] Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay High expression of SNHG1 was exhibited in esophageal squamous cell cancer and indicated poor outcomes of patients. SNHG1 knockdown suppresses migration and invasion but induces apoptosis of esophageal squamous cell cancer cells by increasing miR-204 and decreasing HOXC8. Yes SNHG1 silence led to cell cycle arrest at G0-G1 phase, inhibition of migration and invasion and increase of apoptosis. 32158227 SNHG1 LncRNA Homo sapiens Esophageal Neoplasms EC tissues and cell lines regulation[SNHG1/miR-195/Cdc42 axis ] qRT-PCR It was found SNHG1 and Cdc42 were significantly upregulated, and miR-195 was significantly downregulated in both EC tissues and cell lines. This study might provide deeper insights into the SNHG1/miR-195/Cdc42 axis in EC. Yes In addition, the inhibition of either SNHG1 or Cdc42 resulted in suppression of cell proliferation, migration, and invasion, while inhibition of miR-195 led to opposite results and reversed the effects of si-SNHG1. 33171523 SNHG1 LncRNA Homo sapiens Laryngeal Neoplasms LC tissues Regulation[Notch1 signaling pathway] CCK8//qRT-PCR//Western Blot SNHG1 was upregulated in LC tissues than that of controls. Besides, its level was higher in LC with T3-T4 relative to those of T1-T2.Notch1 overexpression could reverse the regulatory effects of SNHG1 on viability and proliferation of LC cells. SNHG1 was upregulated in LC tissues than that of controls. Besides, its level was higher in LC with T3-T4 relative to those of T1-T2. Higher abundance of SNHG1 was identified in LC patients with lymph node metastasis compared with those non-metastatic patients. Survival analysis indicated that LC patients with high-level SNHG1 had worse overall survival. Yes Knockdown of SNHG1 in Tu212 and Hep2 cells downregulated relative levels of Notch1 and Hes1. Moreover, SNHG1 knockdown resulted in decreased viability and proliferative ability of LC cells. 31378897 SNHG1 LncRNA Homo sapiens Liver Neoplasms HCC tissues Interaction(miR-326/PKM2 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Microarray//ChIP SNHG1 expression was dramatically increased in HCC and positively correlated with poor prognosis. E2F1 bound to the SNHG1 promoter region to activate SNHG1 transcription. Furthermore, SNHG1 served as a molecular sponge for miR-326 to sequester the interaction of miR-326 and pyruvate kinase M2 (PKM2), facilitating the expression of PKM2. SNHG1 expression was dramatically increased in HCC and positively correlated with poor prognosis. Yes E2F1-activated SNHG1 modulates the miR-326/PKM2 axis to facilitate glycolysis and the proliferation of HCC cells. 35816558 SNHG1 LncRNA Homo sapiens Neuroblastoma NB tissues and cells Interaction[targeting miR-338-3p to regulate PLK4 ] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay The expression levels of SNHG1 and PLK4 were increased in NB tissues and cells, and miR-338-3p expression was on the contrary. PLK4 was verified as a direct target of miR-338-3p and miR-338-3p could specially bind to SNHG1. The negative effect of SNHG1 down-regulation on cell proliferation, migration, and invasion could be rescued by miR-338-3p inhibition. The suppression of miR-338-3p mimics on cell proliferation, migration, and invasion could be reversed by PLK4 overexpression. Yes The negative effect of SNHG1 down-regulation on cell proliferation, migration, and invasion could be rescued by miR-338-3p inhibition. In addition, SNHG1 knockdown weakened the volume and weight of tumor in vivo. 31696485 snaR LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Interaction[LncRNA NRON ] CCK8//qRT-PCR In contrast, lncRNA snaR was up-regulated in TNBC tissues and was inversely correlated with NRON.The snaR overexpression resulted in promoted cancer cell proliferation but did not significantly affect NRON expression. NRON overexpression inhibited cancer cell proliferation and down-regulated snaR. The snaR overexpression reduced the effects of NRON overexpression. We therefore conclude that NRON may down-regulate lncRNA snaR to inhibit cancer cell proliferation in TNBC. Yes The snaR overexpression resulted in promoted cancer cell proliferation but did not significantly affect NRON expression. 30996114 snaR LncRNA Homo sapiens ovarian carcinoma plasma Regulation[GAB2 expression] CCK8//qRT-PCR//Western Blot It was observed that plasma levels of lncRNA snaR and GAB2 were significantly higher in OC patients than those in healthy controls. LncRNA snaR may promote proliferation of ovarian carcinoma cells by upregulating GAB2 expression. In effect, high levels of plasma lncRNA snaR and GAB2 distinguished OC patients from healthy controls. Plasma lncRNA snaR and GAB2 were positively correlated in OC patients but not in healthy controls. Yes LncRNA snaR overexpression promoted cancer cell proliferation and upregulated GAB2 expression. 30093110 SLCO4A1-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Regulation[miR-335-5p/OCT4 axis] CCK8//qRT-PCR//Transwell Assay SLCO4A1-AS1 expression was more upregulated in BC tissues than in adjacent normal tissues. High SLCO4A1-AS1 expression level was associated with the progression of BC, and SLCO4A1-AS1 promoted the malignant phenotypes of BC cells through the miR-335-5p/OCT4 axis. Moreover, SLCO4A1-AS1 level was positively correlated with the advanced stage and metastasis in BC. The upregulation of SLCO4A1-AS1 indicates poor prognosis in BC patients. Yes The knockdown of SLCO4A1-AS1 downregulated the proliferation, migration, and invasion of EJ and T24 cells in vitro. 30863101 SMARCA5 CircRNA Homo sapiens Cholangiocarcinoma ICC tissues Expression[lower expressed] qRT-PCR Circ-SMARCA5 expression was reduced in ICC tumor tissues compared to adjacent tissues. Tumor circ-SMARCA5 high expression was negatively associated with Eastern Cooperative Oncology Group performance score, T stage, N stage, TNM stage, and abnormal CA199 status. Furthermore, OS was increased in patients with tumor circ-SMARCA5 high expression compared with those with low expression, and further multivariate Cox's regression demonstrated that tumor circ-SMARCA5 high expression was an independent predictive factor for longer OS. Yes In TFK-1 and HuH-28 ICC cells, circ-SMARCA5 upregulation decreased cell proliferation, reduced relative cell viability in cisplatin-treated as well as gemcitabine-treated cells, and also decreased inhibitory concentration by 50% value (IC50 ) of cisplatin and gemcitabine. 31880360 circRTN4IP1 CircRNA Homo sapiens Cholangiocarcinoma ICC tissues and cells Interaction(miR-541-5p) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay In contrast, ICC tissues and cells showed high expression of circRTN4IP1 and HIF1A, but low expression of miR-541-5p. Yes Knockdown of circRTN4IP1 led to repression of cell proliferation and glucose metabolism, but promotion of cell apoptosis; however, circRTN4IP1 overexpression had opposite effects. 34974242 circACTN4 CircRNA Homo sapiens Cholangiocarcinoma ICC tissues Interaction(miR-424-5p/YBX1 /FZD7) qRT-PCR//RIP//Luciferase Report Assay//Microarray//ChIP In addition, circACTN4 upregulated Yes-associated protein 1 (YAP1) expression by sponging miR-424-5p. More importantly, circACTN4 also recruited Y-box binding protein 1 (YBX1) to stimulate Frizzled-7 (FZD7) transcription. Furthermore, circACTN4 overexpression in ICC cells enhanced the interaction between YAP1 and β-catenin, which are the core components of the Hippo and Wnt signaling pathways, respectively. High circACTN4 expression in ICC was associated with a worse 3-year overall survival and higher recurrence than low circACTN4 expression. Yes High circACTN4 expression was associated with enhanced tumor proliferation and metastasis in vitro and in vivo, as well as a worse prognosis following ICC resection. 34509526 SMASR LncRNA Homo sapiens Lung Neoplasms lung cancer cells Regulation( TGF-β/Smad signaling pathway) RNA Pull-Down//Northern Blot//Western Blot//qRT-PCR//FISH//Luciferase Report Assay//IF Here, we report a novel lncRNA adjacent to Smad3, named Smad3-associated long non-coding RNA (SMASR). SMASR is downregulated by TGF-β via Smad2/3 in lung cancer cells. Mechanistically, SMASR interacts with Smad2/3 and inhibits the expression of TGFBR1, the TGF-β type I receptor responsible for phosphorylation of Smad2/3, thus leading to inactivation of TGF-β/Smad signaling pathway. Yes Knockdown of SMASR induces EMT and increases the migration and invasion of lung cancer cells. Moreover, knockdown of SMASR promotes the phosphorylation of Smad2/3. 33931741 SMARCC2 LncRNA Homo sapiens Stomach Neoplasms gastric cancer cells Interaction(SMARCC2/miR-551b-3p/TMPRSS4 axis ) Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay LncRNA SMARCC2 inhibits the expression of miR-551b-3p through binding to its mRNA response elements in gastric cancer cells. TMPRSS4 is a direct target gene of miR-551b-3p. We conclude that miR-551b-3p functions as a tumour suppressor gene in gastric cancer, and its function is regulated by LncRNA SMARCC2/miR-551b-3p/TMPRSS4 axis. Yes Overexpression of LncRNA SMARCC2 enhances the proliferation and migration of gastric cancer cells, while inhibition of LncRNA SMARCC2 does the opposite. 29337109 SMARCA5 CircRNA Homo sapiens Stomach Neoplasms GC tissues,cell lines(MGC803, SGC7901, N87 and AGS) Interaction[miR-150-5p] qRT-PCR//Western Blot//PCR//IF Our results showed that circSMARCA5 expression was significantly decreased in human gastric cancer tissues and cell lines.Luciferase reporter assays proved that circSMARCA5 acted as a sponge for miroRNA-346 (miR-346) and regulated the expression of F-Box and leucine rich repeat protein 2 (FBXL2). Yes Transfection efficiency assay showed that circSMARCA5 expression was markedly increased after transfection with pLCDH-circSMARCA5 when compared with pLCDH-transfected SGC7901 cells (Fig. 2A). Next, we detected the effect of circSMARCA5 overexpression on proliferation, migration and invasion. CCK-8 assay demonstrated that circSMARCA5 overexpression dramatically sExpression[Expression[up-expression]-expression]pressed the cell proliferation of SGC7901 cells (Fig. 2B). In addition, cell migration and invasion were also reduced by circSMARCA5 overexpression (Fig. 2C and D). 35515212 SMARCA5 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-670-5p/RBM24 axis] qRT-PCR//Luciferase Report Assay The results showed that circsSMARCA5 was expressed at low level in NSCLC tissues and cells, while miR-670-5p had high level in NSCLC tissues. Thus, circsSMARCA5 may serve as an NSCLC suppressor by regulating the miR-670-5p/RBM24 axis, and it may have the potential to be a biomarker or therapeutic target for NSCLC. Yes Moreover, circsSMARCA5 obviously inhibited tumor growth in vivo, reduced cell proliferation and increased cell apoptosis in vitro, while miR-670-5p mimic or RBM24 knockdown could reverse these effects. 33085761 SMARCA5 CircRNA Homo sapiens Colorectal Neoplasms CRC cell lines and tissues regulation[downregulating miR-39-3p and upregulating ARID4B] qPCR//PCR//IF Circ-SMARCA5 expression was dramatically decreased in CRC cell lines and tissues.Circ-SMARCA5 functions as a tumor suppressor by upregulating ARID4B expression via sponging miR-39-3p, and thereby inhibited CRC progression. Yes Circ-SMARCA5 overexpression inhibited CRC cell proliferation, migration and invasion. 32807692 SMARCA5 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Interaction(SND1 /YWHAB) RNA Pull-Down//cell invasion assay//Western Blot//Transfection//qPCR//Proliferation Assay//Cell Apoptosis Assay//PCR//Cell Proliferation Assay//IP//Invasion Assay//IF Quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) results showed that the expression of SMARCA5 was downregulated in cervical cancer tissues and cell lines. Our results showed that overexpression of circ SMARCA5 inhibits the binding of SND1 to YWHAB, and inhibits the proliferation and invasion, but promotes apoptosis in cervical cancer cells, thus inhibiting the metastasis of cervical cancer. Yes Then we found that overexpression of SMARCA5 inhibited proliferation and invasion, but promoted apoptosis in cervical cancer cells. Overexpression of SMARCA5 inhibited cervical cancer metastasis in vivo. 33588586 SMAD7 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC samples and HCC cell lines regulation[miR-125b/SIRT6 axis] qRT-PCR//MTT//Colony Formation Assay//Transwell Assay This study uncovered that Linc-smad7 was increased in HCC samples and HCC cell lines using RT-qPCR assays.In conclusion, the current study first identified Linc-smad7 is increased in HCC, facilitating HCC cells proliferation, migration, invasion and EMT via regulating the miR-125b/SIRT6 axis. Yes Functionally, it was demonstrated that Linc-smad7 could bind with microRNA-125b (miR-125b), and the restoration of miR-125b rescued the promoting effects of Linc-smad7 on HCC cells. 33037850 circNFIB CircRNA Homo sapiens Cholangiocarcinoma ICC tissues Interaction(MEK1) Bioinformatics Analysis cNFIB was significantly down-regulated in human ICC tissues with postoperative metastases. Mechanistically, cNFIB competitively interacted with MEK1, which induced the dissociation between MEK1 and ERK2, thereby resulting in the suppression of ERK signaling and tumor metastasis. cNFIB was significantly down-regulated in human ICC tissues with postoperative metastases.The loss of cNFIB was highly associated with aggressive characteristics and predicted unfavorable prognosis in ICC patients. Yes Functional studies revealed that cNFIB inhibited the proliferation and metastasis of ICC cells in vitro and in vivo. 35039066 SMAD5-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and NPC cell lines Interaction[SMAD5] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//FISH//Luciferase Report Assay//EdU Staining//Transwell Assay High expression of SMAD5-AS1 and SMAD5 but low miR-195 expression was determined in NPC tissues and NPC cell lines by RT-qPCR and western blot analysis. SMAD5-AS1 could upregulate SMAD5 expression by competitively binding to miR-195 in NPC cells. Yes Downregulation of SMAD5-AS1 or SMAD5 or overexpression of miR-195 led to inhibited NPC cell proliferation, invasion and migration and reversed EMT, enhanced apoptosis in vitro as well as restrained tumor growth in vivo. 31921616 SMAD5-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction[microRNA-106a-5p ] RNA Pull-Down//Western Blot//ISH//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay SMAD5-AS1 was highly expressed and miR-106a-5p was poorly expressed in NPC tissues and cell lines.Long noncoding RNA SMAD5-AS1 acts as a microRNA-106a-5p sponge to promote epithelial mesenchymal transition in nasopharyngeal carcinoma. Yes Taken together, SMAD5-AS1 silencing suppressed EMT, cell proliferation, migration, and invasion in NPC by elevating miR-106a-5p to down-regulate SMAD5, which provided a novel therapeutic target for NPC treatment. 31557058 SLNCR1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Tumor tissues and paired healthy tissues Interaction[sPLA2] Western Blot//qRT-PCR//ELISA//Invasion Assay//Transwell Assay Compared with adjacent healthy tissues, the expression levels of lncRNA SLNCR1 were significantly increased in tumor tissues.In conclusion, lncRNA SLNCR1 may regulate cancer cell migration, invasion and stemness in NSCLC through interactions with sPLA2. Yes lncRNA SLNCR1 siRNA silencing inhibited, whereas sPLA2 overexpression promoted cell migratory and invasive abilities and stemness. 31524254 SLCO4A1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC samples and cell lines Interaction(miR-149/XIAP Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//Invasion Assay SLCO4A1-AS1 was significantly upregulated in the GC samples and cell lines, and a high level of SLCO4A1-AS1 was associated with an advanced tumor stage and shortened patient survival. Mechanistically, SLCO4A1-AS1 post-transcriptionally regulated XIAP by functioning as competing endogenous RNA in GC to sponge miR-149. Further functional assays revealed that the overexpression of miR-149 and knockdown of XIAP considerably inhibited GC cell viability and its migratory and invasive characteristics in vitro. SLCO4A1-AS1 was significantly upregulated in the GC samples and cell lines, and a high level of SLCO4A1-AS1 was associated with an advanced tumor stage and shortened patient survival. Yes SLCO4A1-AS1 knockdown also determined the function of GC cells but was diminished by the miR-149 inhibitor in vitro. Finally, we demonstrated that the deletion of SLCO4A1-AS1 suppressed tumor growth and metastasis in vivo. 34650909 SLCO4A1-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cell lines Interaction( miR-149-5p/STAT3 Axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The expressions of SLCO4A1-AS1 and STAT3 were increased, while the expression of miR-149-5p was suppressed in gastric cancer tissues and cell lines. In addition, STAT3 expression was negatively correlated with miR-149-5p expression but was positively correlated with SLCO4A1-AS1 expression. SLCO4A1-AS1 bound to miR-149-5p and targeted STAT3. Moreover, miR-149-5p mimic inhibited the malignant development of gastric cancer cells and obviously reversed the function of SLCO4A1-AS1 overexpression. Yes Overexpression of SLCO4A1-AS1 promoted cell viability, migration, invasion, and STAT3 expression but suppressed apoptosis, while knockdown of SLCO4A1-AS1 had the opposite effect. 34712324 SLCO4A1-AS1 LncRNA Homo sapiens Colorectal Neoplasms control tissues Regulation[miR-508-3p/PARD3 axis ] ISH//qRT-PCR In addition, the expression of SLCO4A1-AS1 was significantly up-regulated in 23 CRC tissues compared with the control tissues (Figure 1C). The current study demonstrates that the SLCO4A1-AS1/miR-508-3p/PARD3/autophagy pathway play a critical role in CRC cell proliferation, and might provide novel targets for developing therapeutic strategies for CRC. Yes In vitro and in vivo studies revealed that SLCO4A1-AS1 knockdown repressed cytoprotective autophagy as assayed by transmission electron microscopy (TEM), and inhibited cell proliferation by directly targeting partition-defective 3 (PARD3). 31308265 SLCO4A1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation(Cdk2/c-Myc signalling) qRT-PCR//IHC//RIP//FISH SLCO4A1-AS1 was frequently upregulated in CRC tissues based on multiple CRC cohorts and was associated with poor prognoses. Aberrant overexpression of SLCO4A1-AS1 in CRC is partly attributed to the DNA hypomethylation of its promoter. Mechanistic investigations revealed that SLCO4A1-AS1 functions as a molecular scaffold to strengthen the interaction between Hsp90 and Cdk2, promoting the protein stability of Cdk2. The SLCO4A1-AS1-induced increase in Cdk2 levels activates the c-Myc signalling pathway by promoting the phosphorylation of c-Myc at Ser62, resulting in increased tumour growth. Yes Ectopic SLCO4A1-AS1 expression promoted CRC cell growth, whereas SLCO4A1-AS1 knockdown repressed CRC proliferation both in vitro and in vivo. 35039060 SLCO4A1-AS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Interaction(miR-150-3p to elevate SLCO4A1 ) qRT-PCR//FISH SLCO4A1-AS1 and SLCO4A1 were screened as the differentially expressed lncRNA and mRNA in colon cancer tissues. SLCO4A1-AS1 was confirmed to competitively bind to miR-150-3p to elevate SLCO4A1 expression. Yes Moreover, knockdown of SLCO4A1-AS1 decreased SLCO4A1 expression, thus inhibiting cell migration, invasion, sphere formation, and tumorigenesis abilities and enhancing the apoptosis of CD133+CD44+ cells. 33958701 circHMGCS1 CircRNA Homo sapiens Cholangiocarcinoma ICC tissues Interaction(miR-1236-3p/CD73 and GAL-8 axis) In Vivo Experiment//Western Blot//ISH//Transfection//qRT-PCR//Luciferase Report Assay//Microarray//ELISA//IHC We identified that compared with peritumor tissues, ICC tissues expressed hsa_circ_0008621 (circHMGCS1-016) high by RNA-seq, which was further identified by qRT-PCR and in situ hybridization. By SILAC and circRNA-pull down, we demonstrated that circHMGCS1-016 induced ICC cell invasion and reshaped the tumor immune microenvironment via the miR-1236-3p/CD73 and GAL-8 axis. Moreover, the expression of circHMGCS1-016 was revealed to be associated with survival and recurrence of ICC patients. Yes By regulating circHMGCS1-016 expression, we found that elevated circHMGCS1-016 promoted ICC development both in vitro and in vivo. 34526098 circSETDB1 CircRNA Homo sapiens Ovarian Neoplasms SOC tissues and cells Interaction(miR-129-3p) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Invasion Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay CircSETDB1 and MAP3K3 expression were apparently upregulated, whereas miR-129-3p expression was downregulated in SOC tissues and cells in comparison with normal fallopian tube tissues or normal ovarian epithelial cells. Additionally, miR-129-3p inhibitor impaired circSETDB1 silencing-mediated SOC malignant progression. Yes CircSETDB1 knockdown inhibited cell proliferation, invasion and migration, but induced cell apoptosis in SOC cells. 34789310 snaR LncRNA Homo sapiens Liver Neoplasms liver cancer tissues Interaction[TGF-β1] qRT-PCR//ELISA//Western Blot The expression of snaR and TGF-β1 was significantly increased in the patients with HCC compared with the healthy controls.snaR overexpression significantly promoted cancer cell migration and invasion, and additionally increased TGF-β1 expression. Treatment with TGF-β1 did not significantly affect snaR expression. A TGF-β1 inhibitor attenuated the effects of snaR overexpression in cancer cell migration and invasion. snaR may promote the metastasis of liver cancer through TGF-β1. Yes snaR overexpression significantly promoted cancer cell migration and invasion, and additionally increased TGF-β1 expression. 31186778 SMIM31 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells and tissues Interaction(microRNA-1301-3p/lactate dehydrogenase isoform A axis) CCK8//qRT-PCR//Luciferase Report Assay//RIP We found that LINC01207 was overexpressed in OSCC cells and tissues. LINC01207 interacted with microRNA-1301-3p (miR-1301-3p) while lactate dehydrogenase isoform A (LHDA) was targeted by miR1301-3p. Effects caused by LINC01207 downregulation on OSCC cells were reversed by overexpression of LDHA. Overall, LINC01207 promotes OSCC progression via the miR-1301-3p/LDHA axis. Yes LINC01207 silencing inhibited OSCC cell proliferation and migration but promoted apoptosis and autophagy, and LINC01207 overexpression had an opposite result. 34463208 snaR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung SPC-A1 and A549 wild-type EGFR cell lines Expression(highly expressed) cell invasion assay//qRT-PCR//Transfection//MTT The expression of snaR was remarkably up-regulated in SPC-A1 and A549 wild-type EGFR cell lines. Yes Down regulation of snaR with small interfering RNA significantly inhibited cell invasion as well as proliferation of SPC-A1 and A549 cells. 35875332 circATAD1 CircRNA Homo sapiens cervical squamous cell carcinoma CSCC tissues Interaction(miR-218) Transfection//qRT-PCR//Cell Apoptosis Assay//BrdU//Transwell Assay CSCC tissues exhibited upregulated expression of circ-ATAD1, which was localized to both nucleus and cytoplasm. Mature miR-218 was downregulated in CSCC tissues and was inversely correlated with circ-ATAD1, while premature miR-218 was not differentially expressed in CSCC. Circ-ATAD1 is upregulated in CSCC and may regulate cell proliferation and apoptosis by suppressing the maturation of miR-218. Yes In addition, overexpression of circ-ATAD1 increased cell proliferation and decreased cell apoptosis, while overexpression of miR-218 decreased cell proliferation and increased cell apoptosis, and it also attenuated the effects of overexpression of circ-ATAD1 on cell proliferation. However, CSCC cell invasion, migration, and stemness were not affected by circ-ATAD1 and miR-218. 34254279 SNAI3-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues interaction[miR-27-3p and miR-34a-5p] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay In this study, qRT-PCR analysis revealed that the expression of SNAI3-AS1 was elevated and was correlated with the levels of PEG10 in HCC tissues. Further bioinformatics analysis and mechanistic experiments showed that SNAI3-AS1 functions as a competing endogenous RNA (ceRNA) to activate PEG10 by acting as a sponge for miR-27-3p and miR-34a-5p. Yes Through functional experiments, we determined that knockdown of SNAI3-AS1 and PEG10 inhibited the proliferation and metastasis, whereas overexpression of SNAI3-AS1 and PEG10 promoted the proliferation and metastasis of HCC cells. 32826862 circPOLA2 CircRNA Homo sapiens cervical squamous cell carcinoma CESC tissues regulation[ miR-326/ GNB1] qRT-PCR Circ_POLA2 was highly expressed in CESC tissues and positively correlated with poor prognosis in CESC patients. In conclusion, circ_POLA2 promotes cervical squamous cell carcinoma development and progression via regulating the miR-326/GNB1 axis, which might serve as a novel therapeutic target for CESC patients. Circ_POLA2 was highly expressed in CESC tissues and positively correlated with poor prognosis in CESC patients. Yes Knockdown of circ_POLA2 using shRNA inhibited cervical cancer cell proliferation, migration, and invasion both in vitro and in vivo. 32766125 SMO-193a CircRNA Homo sapiens Glioblastoma glioblastoma tissues Regulation(FUS/Gli1) Northern Blot//ChIP//TUNEL//ISH//Transfection//Immunoblotting//Tunel//Proliferation Assay//qRT-PCR//FISH//RNA-seq//PCR//IP//IHC//IF Moreover, circ-SMO/SMO-193a.a. is positively regulated by FUS, a direct transcriptional target of Gli1. Shh/Gli1/FUS/SMO-193a.a. form a positive feedback loop to sustain Hedgehog signaling activation in glioblastoma. Clinically, SMO-193a.a. is more specifically expressed in glioblastoma than SMO and is relevant to Gli1 expression. Higher expression of SMO-193a.a. predicts worse overall survival of glioblastoma patients, indicating its prognostic value. Yes Deprivation of SMO-193a.a. in brain cancer stem cells attenuates Hedgehog signaling intensity and suppresses self-renewal, proliferation in vitro, and tumorigenicity in vivo. 33446260 SMO CircRNA Homo sapiens Glioma glioma tissues Interaction[sponging miR-338-3p] Western Blot//qRT-PCR//MTT//PCR//IF CircSMO742 and SMO were highly expressed in glioma tissues, while miR-338-3p expression was reduced. CircSMO742 promoted glioma growth by sponging miR-338-3p to regulate SMO expression. Our research revealed a new molecular mechanism of glioma growth and provide a fresh perspective on circRNAs in glioma progression. Yes Knocking down of circSMO742 suppressed glioma growing in vivo. 31895689 SMIM45 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma esophageal cancer tissues regulation[miR-342-3p/Bcl2L1 Axis] CCK8//qRT-PCR//Luciferase Report Assay//Flow Cytometry The results showed that the expression of LINC00634 in these tissues was higher than that in nontumor tissues and associated with tumor-node-metastasis (TNM) stage of patients. We also show that the knockdown of LINC00634 decreased cell viability and increased cell apoptosis levels in EC9706 and EC1 cells through the miR-342-3p/Bcl2L1 axis. Yes Knockdown of LINC00634 decreased cell viability and increased cell apoptosis levels in EC9706 and EC1 cells. 32583748 SMIM31 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue and cells Interaction( miR-525-5p/ARHGAP11A axis ) qRT-PCR//Western Blot LINC01207 was up-regulated in NSCLC tissue and cells, which was mainly localized in the cytoplasm. LINC01207 could sponge and inhibit the expression of miR-525-5p in NSCLC cells, and inhibiting LINC01207 and miR-525-5p simultaneously could reverse the effect of miR-525-5p on the progression of NSCLC cells. Further study on downstream target genes showed that miR-525-5p could restrain the expression of ARHGAP11A, and then affect the progression of NSCLC. LINC01207 acting as a competing endogenous RNA (ceRNA) could regulate the expression of ARHGAP11A by competitively binding with miR-525-5p. Yes LINC01207 knockdown could inhibit the proliferation, migration and invasion of cancer cells and induce cell apoptosis. In addition, silencing LINC01207 could suppress tumor growth in vivo. 34487020 SMIM31 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues Interaction[sponging miR-143-5p] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay LINC01207 and AGR2 were highly expressed while miR-143-5p was poorly expressed in pancreatic cancer. Functionally, LINC01207 can bind to miR-143-5p, and AGR2 was a target gene of miR-143-5p. Yes Moreover, silencing of LINC01207 and up-regulation of miR-143-5p promoted cell apoptosis and autophagy, corresponding to increased expression of autophagy- and apoptosis-related proteins, in addition to inhibited cell growth. 30991076 circPVT1 CircRNA Homo sapiens Small Cell Lung Carcinoma lung cells Interaction( PVT1/AKT3) Northern Blot//Western Blot//Transfection//Flow Cytometry//qRT-PCR In detail, circPVT1 activated a pro-proliferative and anti-apoptotic program when over-expressed in lung cells, and knockdown of chimPVT1 induced a decrease in cell growth and an increase of apoptosis in SCLC in vitro. Moreover, the investigated PVT1 transcripts underlined a functional connection between MYC and YAP1/POU2F3, suggesting that they contribute to the transcriptional landscape associated with MYC amplification. Yes In detail, circPVT1 activated a pro-proliferative and anti-apoptotic program when over-expressed in lung cells, and knockdown of chimPVT1 induced a decrease in cell growth and an increase of apoptosis in SCLC in vitro. Moreover, the investigated PVT1 transcripts underlined a functional connection between MYC and YAP1/POU2F3, suggesting that they contribute to the transcriptional landscape associated with MYC amplification. 36562080 SMIM31 LncRNA Homo sapiens Prostatic Neoplasms regulation[microRNA-1972 ,LIM ,SH3 protein 1] qRT-PCR//Luciferase Report Assay//RIP//FISH Quantitative real-time polymerase chain reaction revealed that LINC01207 and LASP1 were highly expressed in prostate cancer, while miR-1972 expression was lower. The interaction among LINC01207, miR-1972, and LASP1 was confirmed by RNA-fluorescence in situ hybridization, RNA immunoprecipitation, and dual luciferase reporter assay, which verified that LINC01207 could bind to miR-1972 and downregulate miR-1972, and miR-1972 targeted LASP1 and negatively regulated its expression. Yes Both in vitro and in vivo experiments found that silencing LINC01207 inhibited cell proliferation, migration, invasion and tumor formation and enhanced apoptosis in prostate cancer cells, suggesting that LINC01207 functioned as a tumor promoter in prostate cancer and that it may represent a novel therapeutic target. 32726517 SMIM31 LncRNA Homo sapiens Prostatic Neoplasms PC cells and tumor tissues Interaction(miR-1182) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay LINC01207 expression was significantly increased in PC cells and tumor tissues compared with in normal prostate cells (RWPE1) and normal prostate tissues, respectively. Mechanistic experiments showed that LINC01207 promoted carcinogenesis by sponging miR-1182 to regulate the protein levels of AKT3 in PC cell lines.  Yes Furthermore, LINC01207 silencing inhibited PC cell proliferation and colony formation and induced apoptosis. 34992689 SMIM30 LncRNA Homo sapiens Leukemia, Myeloid, Acute human AML Interaction(ZFP36/mTORC2 axis) CCK8//qRT-PCR LINC00998 was significantly decreased in human AML, which was linked to relapse and poor prognosis. LINC00998 was mainly located in the cytoplasm, in which interacted with ZFP36 ring finger protein (ZFP36), a mRNA destabilizing factor, resulting in increased decay of mammalian target of rapamycin complex 2 (mTORC2), a well-known proto-oncogene in AML. Yes Stable overexpression of LINC00998 inhibited AML cell viability, colony ability, DNA synthesis rate and increased apoptosis. Importantly, LINC00998 shortened in vivo AML cell survival in xenograft tumor model. 34699314 SMIM30 LncRNA Homo sapiens Glioblastoma glioblastoma tissues regulation[ CBX3-mediated c-Met/Akt/mTOR axis] RNA Pull-Down//Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay//IF Through screening using TCGA database, we found that LINC00998 was downregulated in glioblastoma tissues and that low expression of LINC00998 was associated with poor prognosis. Mechanistically, RNA pull-down and mass spectrometry results showed an interaction between LINC00998 and CBX3. IP assays demonstrated that LINC00998 could stabilize CBX3 and prevent its ubiquitination degradation. GSEA indicated that LINC00998 could regulate the c-Met/Akt/mTOR signaling pathway, which was further confirmed by a rescue assay using siRNA-mediated knockdown of CBX3 and the Akt inhibitor MK2206. In addition, dual-luciferase assays showed that miR-34c-5p could directly bind to LINC00998 and downregulate its expression. Yes Overexpression of LINC00998 inhibited glioma cell proliferation in vitro and in vivo and blocked the G1/S cell cycle transition, which exerted a tumor-suppressive effect on glioma progression. 33268783 hsa_circ_0000615 CircRNA Homo sapiens Nasopharyngeal Neoplasms NPC tissues and cells regulation[miR-338-3p/FGF2 axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay We detected increased levels of circ_0000615 and FGF2, along with a decreased level of miR-338-3p in NPC tissues and cells. In conclusion, our findings demonstrated that circ_0000615 knockdown suppressed the growth of NPC cells via modulating miR-338-3p/FGF2 axis, providing a theoretical basis for the treatment of NPC. Yes Circ_0000615 knockdown suppressed the proliferation, migration, invasion, and EMT of NPC cells. 32453598 SMIM27 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer cell Interaction(VDR/Wnt/β-catenin signaling ) qRT-PCR//RIP//IP//Colony Formation Assay//ChIP Analysis of tumor cell transcriptomes indicated TOPORS-AS1's influence on the Wnt/β-catenin signaling. Additional experiments revealed that TOPORS-AS1 increased the phosphorylation of β-catenin and suppressed the expression of CTNNB1, disrupting the Wnt/β-catenin pathway. Our experiments further discovered that vitamin D receptor (VDR) upregulated TOPORS-AS1 expression and that inhibition of β-catenin by TOPORS-AS1 required a RNA binding protein, hnRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2B1). Patients with high TOPORS-AS1 expression had favorable overall survival compared to low expression. Yes In vitro experiments demonstrated that overexpressing TOPORS-AS1 in ovarian cancer cells suppressed cell proliferation and inhibited aggressive cell behaviors, including migration, invasion, and colony formation. 33820921 circVAPA CircRNA Homo sapiens Small Cell Lung Carcinoma SCLC cell lines, clinical tissues, and serum from SCLC patients Interaction(miR-377-3p and miR-494-3p/IGF1R/AKT axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay We revealed that circVAPA, derived from exons 2-4 of the vesicle-associated membrane protein-associated protein A (VAPA) gene, exhibited higher expression levels in SCLC cell lines, clinical tissues, and serum from SCLC patients than the controls, and facilitated SCLC progression in vitro and in vivo. Mechanistically, circVAPA activated the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway by modulating the miR-377-3p and miR-494-3p/insulin-like growth factor 1 receptor (IGF1R) axis to accelerate SCLC progression. Yes We revealed that circVAPA, derived from exons 2-4 of the vesicle-associated membrane protein-associated protein A (VAPA) gene, exhibited higher expression levels in SCLC cell lines, clinical tissues, and serum from SCLC patients than the controls, and facilitated SCLC progression in vitro and in vivo. Furthermore, circVAPA depletion markedly enhanced the inhibitory effects of BMS-536924, an IGF1R kinase inhibitor in cellular and xenograft mouse models. 35668527 SMILR LncRNA Homo sapiens Pulmonary Arterial Hypertension blood regulation[RhoA/ROCK signaling ] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//MTT//Luciferase Report Assay SMILR and RhoA expression were upregulated, while miR-141 expression was downregulated in PAH patients.Knockdown of SMILR effectively elevated miR-141 expression and in turn inhibited the RhoA/ROCK pathway to regulate vascular remodeling and reduce blood pressure in PAH. Yes Knockdown of SMILR suppressed PASMC proliferation and migration induced by hypoxia. 32559140 SCHLAP1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell Interaction( AUF1/PD-L1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//EdU Staining//Transwell Assay In conclusion, our data for the first time uncover that SChLAP1 functions an oncogene in NSCLC by promoting cancer cell immune evasion via regulating the AUF1/PDL1 axis, targeting of SChLAP1 may be a potential approach to improve the efficacy of immunotherapy in NSCLC patients. Yes In this study, we found that depletion of SChLAP1 significantly inhibited NSCLC cell proliferation, migration and invasion in vitro, and retarded tumour growth and lung metastasis in vivo. SChLAP1 facilitated NSCLC cell immune evasion against CD8+ T cells through PD-1/PD-L1 immune checkpoint. 33904361 SCARNA2 LncRNA Homo sapiens Skin Neoplasms cSCC tissues,cell lines regulation[miR-342-3p expression] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay We found that SCARNA2 expression is up-regulated in cSCC cell lines and SCARNA2 expression is higher in cSCC tissues than in adjacent non-tumor specimens. We found that elevated expression of SCARNA2 promotes cell growth, cell cycle and invasion via regulating miR-342-3p expression in SCC13 cells. Yes Ectopic expression of SCARNA2 promoted cell growth, cell cycle and invasion in SCC13 cells. 32558970 circMCTP2 CircRNA Homo sapiens bladder carcinoma BC tissues and cell lines Interaction(miR-498/MDM2) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In our study, circMCTP2 expression was strongly increased in BC tissues and cell lines. In BC cells, circMCTP2 deficiency enhanced the translation of E-cadherin, while diminishing the translation of N-cadherin, Vimentin, and Snail. Moreover, circMCTP2 acted as a sponge of miR-498 to regulate murine double minute-2 (MDM2) expression. In BC tissues, a negative correlation was observed between the expression levels of circMCTP2 and miR-498. Additionally, either miR-498 silencing or MDM2 over-expression augmented the carcinogenic action of circMCTP2 on BC. High expression of circMCTP2 predicted a poor prognosis of BC patients. Yes CircMCTP2 deficiency impaired the cell growth, migration as well as invasive ability of BC cell lines (J82 and T24). In vivo, circMCTP2 deficiency cut the tumor growth rates and the tumor weight. 35475453 hsa_circ_0000592 CircRNA Homo sapiens stomach carcinoma cell line Expression[highly expressed] qRT-PCR//circRNA-seq//FISH When compared with GES-1-N cells, hsa_circ_0000592 was obviously Expression[up-expression]-regulated in GES-1-T cells, as well as in other gastric cancer cell lines. Yes The silencing of hsa_circ_0000592 mRNA led to a decrease in cell proliferation, cell cycle arrest at the G0/G1 phase, an increased rate of apoptosis, and a reduction in cell migration. 31189743 RP9P LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-133a-3p/FOXQ1 Axis) CCK8//Luciferase Report Assay//IHC//Western Blot RP9P was overexpressed in CRC compared to normal control tissues and cells. RP9P directly interacted with miR-133a-3p, and miR-133a-3p downregulation abrogated the tumor-suppressing effect of RP9P knockdown. miR-133a-3p directly targeted FOXQ, which was positively regulated by RP9P. RP9P knockdown decreased FOXQ1 expression levels in CRC cells by directly targeting miR-133a-3p via a sponge mechanism. Yes Knockdown of RP9P inhibited CRC cell viability. In addition, in vivo experiments in a xenograft model revealed that downregulated RP9P expression inhibited CRC cell tumorigenesis. 35600345 circPRRX1 CircRNA Homo sapiens stomach carcinoma tissues and cells Interaction(MicroRNA-665/YWHAZ Axis) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Compared with normal tissues and cells, circ-PRRX1 and YWHAZ levels were upregulated, and miR-665 was downregulated in GC tissues and cells. Mechanistically, circ-PRRX1 was confirmed as a sponge of miR-665 to regulate YWHAZ expression. Yes Functionally, circ-PRRX1 knockdown inhibited the viability, migration, and invasion and promoted apoptosis in GC cells, whereas anti-miR-665 abolished these effects. Xenograft mouse model suggested that circ-PRRX1 knockdown reduced GC cells growth in vivo. 33201331 circMTO1 CircRNA Homo sapiens stomach carcinoma GC tissues and cells regulation[miR-3200-5p/PEBP1 axis] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this study, our experimental results delineated that circMTO1 exhibited much lower expression level in GC tissues and cells. In a word, this study was the first to indagate the underlying mechanism of circMTO1 in GC and confirmed circMTO1 exerted its anti-cancer effects by miR-3200-5p/PEBP1 axis, implying that circMTO1 may become a new promising therapeutic target for GC patients. Yes CircMTO1 overexpression slowed down GC progression via inhibiting cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process. 32194149 circFOXO3 CircRNA Homo sapiens stomach carcinoma interaction[USP44, miR-143-3p] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP All the data indicate that circFOXO3 promotes GC cell proliferation and migration by upregulating USP44 expression via targeting of miR-143-3p. Yes CircFOXO3 enhanced GC cell proliferation and migration in vitro and promoted tumor growth of GC cells in vivo. 32445925 RP5-916L7.2 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues Interaction[targeting miR-328-5p and miR-939-5p] qPCR//CCK8//FISH//Luciferase Report Assay//Colony Formation Assay lncRNA RP5-916L7.2 was increased in tumor tissue compared with paired adjacent tissue. lncRNA RP5-916L7.2 was up regulated in tumor tissue and positively correlated with tumor stage, and promoted cells proliferation while inhibited cells apoptosis by targeting miR-328-5p and miR-939-5p in TSCC. lncRNA RP5-916L7.2 was increased in tumor tissue compared with paired adjacent tissue, and correlated with higher T stage, N stage as well as TNM stage in TSCC patients. Yes In vitro experiments revealed that lncRNA RP5-916L7.2 promoted cells proliferation and repressed cells apoptosis in Tca-8113 cells. 30825424 circPTK2 CircRNA Homo sapiens stomach carcinoma GC tissues and cells regulation[miR-139-3p] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot High expression of circPTK2 was presented in GC tissues and cells. CircPTK2 promotes GC development by sponging miR-139-3p, which may function as an effective gene target for managing GC. Yes The circPTK2 knockdown notably suppressed cell proliferation and promoted cell apoptosis in GC. 32504353 hsa-circ-0007766 CircRNA Homo sapiens stomach carcinoma GC tissues and GC cell lines regulation[miR-1233-3p/ GDF15 axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//FISH Interestingly, we found that hsa-circ-0007766 was highly expressed in human GC tissues and GC cell lines.This study unveils a mechanism by which hsa-circ-0007766 regulates GDF15 via hsa-circ-0007766/miR-1233-3p/GDF15 axis, which may provide new insight for GC therapeutic strategies. Yes Knock-down of hsa-circ-0007766 inhibited cell proliferation, migration, invasion, and down-regulated the expression of GDF15. 32669960 RP5-881L22.5 LncRNA Homo sapiens Colorectal Neoplasms 4 pairs of colorectal cancer patients Expression(highly expressed) qRT-PCR//Transwell Assay When quantitative reverse transcription PCR was performed on tumor tissues from 4 pairs of colorectal cancer patients, the results showed that RP5-881L22.5 was highly expressed. Yes Subsequently, knocking down the expression of RP5-881L22.5, the invasiveness of colorectal cancer cell lines was reduced, and the apoptosis rate was increased. 36438707 RP5-1120P11.3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation[miR-196b-5p-WIPF2 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining To evaluate the role of lncRNAs in HCC, we examined six lncRNAs and found that only RP5-1120P11.3 was significantly increased in the HCC cell line HepG-2 compared with the human immortalized liver cell line HL-7702 (Fig. 1A). Next, we assessed the expression level of RP5-1120P11.3 in 12 paired HCC tissues and adjacent noncarcinoma control tissues from HCC patients, and our results showed that RP5-1120P11.3 was dramatically increased in tumor tissues in comparison with adjacent normal tissues (Fig. 1B). These findings suggested that the RP5-1120P11.3-miR-196b-5p-WIPF2 axis is a potential target for treatment of HCC. Yes Further characterization of RP5-1120P11.3 revealed that it promoted proliferation and invasion of HCC cells while inhibiting apoptosis.  31299165 hsa_circ_0000979 CircRNA Homo sapiens stomach carcinoma GC samples Interaction(miR-136/SP1 ) qRT-PCR We found that circ-0000979 is significantly upregulated in GC samples. CircRNA interactome predicted miR-136 as circ-0000979 targeting miRNA, while starbase prediction result showed that miR-136 targeted the 3'UTR region of SP1 mRNA. Taken together, our results demonstrated that circ-0000979, as a carcinogenic circRNA, promotes the progression of GC by regulating the miR-136/SP1 pathway. Yes Functionally, silencing circ-0000979 leads to a significant reduction in GC cell proliferation and migration. In vivo assays showed that circ-0000979 knockdown markedly reduced GC tumor growth. 36629013 RP4-773N10.4 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 RP4-758J18.10 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[lower expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 RP4-694A7.2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines Regulation(PSAT1) qRT-PCR//FISH//Colony Formation Assay//Transwell Assay RP4-694A7.2 levels were higher in HCC tissues than in normal liver tissues in published GSE datasets and were elevated in HCC cell lines. Finally, phosphoserine aminotransferase 1 (PSAT1) was found to be regulated by RP4-694A7.2 to modulate growth and metastasis in HCC cells using a rescue assay. Yes Cell function assays revealed that RP4-694A7.2 promotes cell proliferation, invasion, and migration. 34405023 RP1-86C11.7 LncRNA Homo sapiens Glioma glioma tissues Interaction(hsa-miR-144-3p/TFRC signaling) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay We also found that the lncRNA RP1-86C11.7 sponges hsa-miR-144-3p to suppress its protective role in glioma. By contrast, silencing RP1-86C11.7 upregulated the hsa-miR-144-3p level, resulting in decreased TFRC expression and repressed glioma progression. echanistically, our data indicated that RP1-86C11.7 exacerbates the malignant behavior of glioma through the hsa-miR-144-3p/TFRC axis. Yes RP1-86C11.7 overexpression in glioma cells elevated TFRC expression, increased the intracellular free iron level, and deteriorated oncogenicity, with a significant reduction in hsa-miR-144-3p. 34571345 RP1-85F18.6 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Expression[highly expressed] qRT-PCR lncRNA, RP1?85F18.6, was upregulated in colorectal cancer (CRC) tissues and cell lines. Yes Knockdown of lncRNA RP1?85F18.6 served a key role in tumor inhibition, reduced cell proliferation and invasion, disrupted the cell cycle, and increased apoptosis and pyroptosis of CRC cells. 30226619 RP11-89K21.1 LncRNA Homo sapiens Peste-des-Petits-Ruminants LUAD tissues and cell lines Interaction(miR-146a/b-5p/RhoA/ROCK Pathway) Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis The authors identified that RP11-89K21.1 was highly expressed in LUAD tissues and cell lines.Mechanistically, RP11-89K21.1 could directly bind miR-146a-5p and miR-146b-5p and decrease their expression to upregulate RHPN2, and subsequently activated RhoA/ROCK pathway. Moreover, upregulated RP11-89K21.1 was strongly associated with unfavorable overall survival of patients with LUAD. Yes Knockdown of RP11-89K21.1 significantly suppressed proliferation and sensitized cell to gefitinib. 33877886 RP11-867G2.8 LncRNA Homo sapiens Chordoma chordoma tissues and cells Interaction(EIF4B and PABPC1/FUT4) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//Migration Assay//qRT-PCR//FISH//MTT//Microarray//Colony Formation Assay We found that RP11-867G2.8 is highly expressed in chordoma tissues and cells, and RP11-867G2.8 overexpression promotes the malignant biological behavior of chordoma cells. RP11-867G2.8 overexpression alters the expression pattern of genes modulating signaling pathway. FUT4 is accumulated in chordoma tissues, and RP11-867G2.8 is antisense RNA of FUT4. RP11-867G2.8 can bind to FUT4 mRNA, increasing FUT4 mRNA stability and facilitating translation of FUT4. RP11-867G2.8 binds to EIF4B and PABPC1, which increases the translation of FUT4. Further studies found that FUT4 silence counteracts the effect of RP11-867G2.8 in vivo and in vitro. Yes We found that RP11-867G2.8 is highly expressed in chordoma tissues and cells, and RP11-867G2.8 overexpression promotes the malignant biological behavior of chordoma cells. RP11-867G2.8 overexpression alters the expression pattern of genes modulating signaling pathway. 35411246 RP11-805J14.5 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cell and tissues Interaction(miR‑34b‑3p and miR‑139‑5p/CCND2 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay RP11‑805J14.5 was highly expressed in LUAD and associated with poor survival of LUAD patients. Our study demonstrated that the regulation of RP11‑805J14.5 on LUAD was mediated by CCND2 whose expression was regulated by sponging miR‑34b‑3p and miR‑139‑5p. RP11‑805J14.5 was highly expressed in LUAD and associated with poor survival of LUAD patients. Yes Knockdown of RP11‑805J14.5 suppressed LUAD cell growth, invasion, migration and tumor growth, indicating that RP11‑805J14.5 is an important regulator of LUAD. 35866595 circGSPT1 CircRNA Homo sapiens stomach carcinoma GC tissues and cells Interaction(GSPT1-238aa) qRT-PCR In our study, circRNA sequencing was carried out using five pathologically diagnosed gastric carcinoma (GC) samples and their paired adjacent normal tissues, we characterized the circRNA GSPT1 (circGSPT1), which is expressed at low levels in GC. Our study reveals that GSPT1-238aa, a novel protein encoded by circGSPT1, halts GC tumorigenesis. Yes CircGSPT1 and GSPT1-238aa halted the proliferation, migration, and invasion in GC cells in vitro. 35839920 circAPC CircRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues Regulation[Wnt/β-catenin signaling] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray//ChIP We identified a novel and highly stable circRNA originating from the back-splicing of APC exon 7 to exon 14, circ-APC (hsa_circ_0127621), which was Expression[down-expression]regulated in DLBCL tissues, cell lines and plasma.Cytoplasmic circ-APC functioned as a sponge for miR-888, thus post-transcriptionally Expression[Expression[up-expression]-expression]regulating APC by alleviating the repressive effects of miR-888 on this gene. Further, nuclear circ-APC bound to the APC promoter and recruited the DNA demethylase TET1, thereby transcriptionally Expression[Expression[up-expression]-expression]regulating APC. Expression[Expression[up-expression]-expression]on its Expression[Expression[up-expression]-expression]regulation, APC dampened the canonical Wnt/β-catenin signaling pathway by reducing the accumulation of β-catenin in the nucleus, thereby retarding DLBCL growth. Yes In gain-of-function experiments, ectopic expression of circ-APC inhibited DLBCL cell proliferation in vitro and tumor growth in vivo. 31631067 RP11-757G1.5 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[RP11-757G1.5/miR-139-5p/YAP1 regulatory axis] RNA Pull-Down//ISH//Wound Healing Assay//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We discovered a novel oncogenic lncRNA RP11-757G1.5, that was overexpressed in CRC tissues, especially in aggressive cases.Altogether, these results reveal a novel RP11-757G1.5/miR-139-5p/YAP1 regulatory axis that participates in CRC carcinogenesis and progression. Moreover, up-regulation of RP11-757G1.5 strongly correlated with poor clinical outcomes of patients with CRC. Yes Functional analyses revealed that RP11-757G1.5 promoted cell proliferation in vitro and in vivo. Furthermore, RP11-757G1.5 stimulated cell migration and invasion in vitro and in vivo. 33023613 circABCB10 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines Regulation[miR-1252/FOXR2 axis] CCK8//qRT-PCR//Transwell Assay The results showed that the expression of circABCB10 in NSCLC cell lines was increased. Fluorescein reporting experiments confirmed that circABCB10 expression increased FOXR2 levels by sponging miR-1252, and in vivo experiments found that knockExpression[down-expression] of circABCB10 decreased tumor growth. Yes Expression[down-expression]regulation of circABCB10 sExpression[Expression[up-expression]-expression]pressed NSCLC cell proliferation and migration by promoting microRNA miR-1252 expression and sExpression[Expression[up-expression]-expression]pressing Forkhead box 2 (FOXR2). 30417418 RPL34-DT LncRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues and the CRC cell lines Regulation( HSP70 and PI3K/AKT signaling pathway) In Vivo Experiment//cell invasion assay//Western Blot//qRT-PCR//RNA-seq//Cell Apoptosis Assay//Cell Proliferation Assay From the results, we found that RP11-462C24.1 was significantly decreased in CRC tumor tissues and the CRC cell lines, which were most significant in SW480 and HT-29 cell lines; additionally, 70 kD heat shock proteins (HSP70) has been identified as one of the most significantly deferentially expressed genes by RNA-seq, and we further confirmed that RP11-462C24.1 may affect the growth and metathesis of CRC cells via regulating HSP70 and PI3K/AKT signaling pathway. Yes moreover, transient overexpression of RP11-462C24.1 suppressed the growth and migration while promoted apoptosis of SW480 and HT-29 cells, while knockdown of RP11-462C24.1 has shown the opposite effects; RP11-462C24.1 may also inhibit the growth of CRC tumors in xenograft mice models; 32946066 RPL34-DT LncRNA Homo sapiens Thyroid Cancer, Papillary " PTC tissues,cell lines" Interaction[miR-3663-3p/RGS4 ] Western Blot//CCK8//RIP//Luciferase Report Assay//Transwell Assay "We used qRT‐PCR analysis to examine the RPL34‐AS1 expression in 77 PTC and adjacent normal tissues, and RPL34‐AS1 expression was significantly downregulated in the PTC tissues compared with that in normal tissues (Figure 2b). The RPL34‐AS1 expression was also verified in both normal thyroid cells (Nthy‐ori 3‐1) and PTC cell lines (BCPAP, KTC‐1, and K1 cells), and the RPL34‐AS1 expression in PTC cells was significantly lower than that in normal thyroid cells; among these cell lines, the decrease of K1 in these PTC cells is most obvious (Figure 2c). " Yes We found that overexpression of RPL34-AS1 could inhibit proliferation and invasion while promoting apoptosis in PTC cell lines. 31587286 circABCC2 CircRNA Homo sapiens Liver Neoplasms Interaction[MiR-665] Western Blot//CCK8//RIP//qRT-PCR//Luciferase Report Assay//Transwell Assay qRT-PCR verified that circABCC2 was overexpressed in HCC. Luciferase assays and RIP showed that circABCC2 and ABCC2 could directly bind to miR-665 and that circABCC2 could regulate ABCC2 expression by sponging miR-665. Yes Inhibition of circABCC2 suppressed HCC cell proliferation and invasion, but promoted apoptosis. 31417632 hsa_circ_0091570 CircRNA Homo sapiens Liver Neoplasms HCC tissues,cell lines Interaction[sponging hsa-miR-1307] CCK8//qRT-PCR//Wound Healing Assay//EdU Staining RNA immunoprecipitation assay verified the interaction of hsa_circ_0091570 and miR-1307. The miR-1307 inhibitor inhibited the function induced by hsa_circ_0091570 siRNA. The decreased expression of hsa_circ_0091570 was associated with the pathological staging of HCC patients. Yes Furthermore, inhibition of hsa_circ_0091570 promoted cell proliferation and migration, blocked cell apoptosis in HCC cell lines, and promoted tumor growth in the mouse xenograft model. 31207319 hsa_circ_0007841 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell line Interaction(miR-199a-5p/SphK2 axis) In Vivo Experiment//IHC//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//IF//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Experimental studies have shown that the higher expression of circ_0007841 in NSCLC tissues, and circ_0007841 strengthen cell viability, cell proliferation and cell adhesion. In addition, miR-199a-5p exerts an inhibitory effect in NSCLC cells by inhibiting SphK2. And Sphk2 regulates cell proliferation and adhesion. Yes Experimental studies have shown that the higher expression of circ_0007841 in NSCLC tissues, and circ_0007841 strengthen cell viability, cell proliferation and cell adhesion. In addition, in-vivo silencing of circ_0007841 was found to inhibit the growth of NSCLC tumors. 36066393 circHMGA2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-331-3p/HMGA2 axes) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//Cell Proliferation Assay//Invasion Assay CircHMGA2 was overexpressed in NSCLC, and high circHMGA2 level might be related to NSCLC metastasis and poor prognosis. Through interacting with miR-331-3p, circHMGA2 could regulate the expression of HMGA2. In addition, circHMGA2/miR-331-3p and miR-331-3p/HMGA2 axes were affirmed in NSCLC regulation. CircHMGA2 was overexpressed in NSCLC, and high circHMGA2 level might be related to NSCLC metastasis and poor prognosis. Yes In-vitro assays suggested that NSCLC cell growth, metastasis and glycolysis were retarded by downregulation of circHMGA2. Upregulation of HMGA2 was shown to return the anticancer response of circHMGA2 knockdown in NSCLC cells. In-vivo analysis indicated that circHMGA2 inhibition also reduced tumorigenesis and glycolysis of NSCLC via the miR-331-3p/HMGA2 axis. 36066399 circABCB10 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue regulation[miR-584-5p/E2F5 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We analyzed the human circRNA expression profile in NSCLC tissues. CircABCB10 was identified as a circRNA that increased in NSCLC tissues. CircABCB10 promoted the progression of NSCLC by modulating the miR-584-5p/E2F5 axis. CircABCB10 was noticeably raised in NSCLC, and high circABCB10 expression was related to low survival in NSCLC patients. Yes Silencing of circABCB10 suppressed non-small cell lung cancer cell migration, cell proliferation, and invasion. 32420810 circCDYL CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expressionhighly expressed] Microarray Circ-CDYL (chromodomain Y like) is specifically Expression[Expression[up-expression]-expression]-regulated in the early stages of HCC and therefore contributes to the properties of epithelial cell adhesion molecule (EPCAM)-positive liver tumor-initiating cells. irc-CDYL interacts with mRNAs encoding hepatoma-derived growth factor (HDGF) and hypoxia-inducible factor asparagine hydroxylase (HIF1AN) by acting as the sponge of miR-892a and miR-328-3p, respectively. Subsequently, activation of the phosphoinositide 3-kinase (PI3K)-AKT serine/threonine kinase-mechanistic target of rapamycin kinase complex 1/β-catenin and NOTCH2 pathways, which promote the expression of the effect proteins, baculoviral IAP repeat containing 5 (BIRC5 or SURVIVIN) and MYC proto-oncogene, is influenced by circ-CDYL. Yes A treatment incorporating circ-CDYL interference and traditional enzyme inhibitors targeting PI3K and HIF1AN demonstrated highly effective inhibition of stem-like characteristics and tumor growth in HCC. 31148183 RPL13AP20 LncRNA Homo sapiens Glioma glioma tissues and cell lines regulation[ miRNA-335] qRT-PCR//Luciferase Report Assay HANR was significantly upregulated in glioma tissues and cell lines. In addition, HANR aggravates the progression of glioma by negatively regulating miRNA-335. Glioma patients with a high expression level of HANR presented remarkably higher rates of lymphatic metastasis and distant metastasis, as well as worse prognosis. Yes The silence of HANR remarkably attenuated the proliferative, migratory, and invasive capacities of U251 and SHG44 cells. 32016979 hsa_circ_0001578 CircRNA Homo sapiens Diabetes, Gestational placental villous tissues Expression(lower expressed) Western Blot//Transfection//Wound Healing Assay//CCK8//ELISA//Colony Formation Assay//Transwell Assay In particular, using qRT-PCR, we verified previous RNA-seq results showing that circ_0001578 is significantly downregulated in the placental villous tissues of pregnant women with GMD. Yes Furthermore, in HTR-8/SVneo trophoblasts, the downregulation of circ_0001578 inhibited proliferation and migration and induced apoptosis. These changes may induce chronic inflammation in the placenta. 36263320 hsa_circ_0005243 CircRNA Homo sapiens Diabetes, Gestational placenta and plasma regulation[ β-catenin and NF-κB pathways] qRT-PCR//RNA-seq Expression of hsa_circ_0005243 was significantly reduced in both the placenta and plasma of GDM patients.Downregulation of hsa_circ_0005243 may be associated with the pathogenesis of GDM via the regulation of β-catenin and NF-κB signal pathways, suggesting a new potential therapeutic target for GDM. Yes Knockdown of hsa_circ_0005243 in trophoblast cells significantly suppressed cell proliferation and migration ability. 32434530 circPCBP2 CircRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse human DLBCL specimens and cultured DLBCL cells Interaction(miR-33a/b/PD-L1) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Apoptosis Assay circPCBP2 was upregulated in human DLBCL specimens and cultured DLBCL cells while miR-33a/b was reduced. circPCBP2 directly bound with miR-33a/b while miR-33a/b targeted PD-L1 3'-UTR. circPCBP2 disinhibited PD-L1 signaling via sponging miR-33a/b. miR-33a/b inhibitor and activating PD-L1 reversed the effects of circPCBP2 knockdown and miR-33a/b mimics, respectively. Yes Knockdown of circPCBP2 or miR-33a/b overexpression inhibited the stemness of DLBCL cells and promoted cancer cell apoptosis upon CHOP treatment. circPBCP2 knockdown restrained DLBCL growth in vivo and potentiated the anti-tumor effects of CHOP. 35579082 circZNF609 CircRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse OCI-LY19 cells Interaction(miR-153) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay Down-regulation of circZNF609 inhibits the proliferation of diffuse large B-cell lymphoma OCI-LY19 cells and induces apoptosis by targeting miR-153. Yes Down-regulation of circZNF609 inhibits the proliferation of diffuse large B-cell lymphoma OCI-LY19 cells and induces apoptosis by targeting miR-153. 35316873 hsa_circ_0000877 CircRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues and cell lines Interaction(miR-370-3p/MAP4K4/Hippo pathway) In Vivo Experiment//Transfection//Invasion Assay//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//IHC//EdU Staining The expression of circ_0000877 was markedly elevated in DLBCL tissues and cell lines. Then, miR-370-3p directly interacted with circ_0000877 and MAP4K4. Circ_0000877 promoted MAP4K4 level by sponging miR-370-3p. MAP4K4 depletion inhibited the activation of Hippo pathway. Finally, circ_0000877 silencing significantly prevented the growth of DLBCL cells in vivo . Our findings revealed that circ_0000877 could regulate the malignant evolution of DLBCL by miR-370-3p/MAP4K4/Hippo pathway. Yes The decreased expression of circ_0000877 significantly inhibited proliferation, migration, and invasion of DLBCL cell lines. In addition, silencing circ_0000877 promoted cell apoptosis and induced cell cycle arrest in G0/G1 phase. 36066383 RPL13AP20 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[miRNA-140-5p] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay HANR expression was significantly up-regulated in NSCLC tissues and cell lines.LncRNA HANR accelerates the proliferative, migratory and invasive abilities of NSCLC via negatively mediating miRNA-140-5p. HANR expression was positively correlated with lymphatic metastasis and distant metastasis of NSCLC patients, whereas it was negatively correlated with the overall survival of NSCLC patients. Yes Knockdown of HANR markedly suppressed the proliferative, migratory and invasive abilities of NSCLC cells. 32016972 circOTUD7A CircRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse 50 pairs of DLBCL tissues (DLBCL) and adjacent normal tissues (Normal) Interaction(miR-431-5p/FOXP1 axis) Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_OTUD7A was highly expressed in DLBCL, and its knockdown could inhibit DLBCL cell proliferation and metastasis, while promote cell cycle arrest and apoptosis. Similarly, FOXP1 also was upregulated in DLBCL, and its silencing could restrain the progression of DLBCL cells. Further experiments revealed that circ_OTUD7A could sponge miR-431-5p and miR-431-5p could target FOXP1. Yes Circ_OTUD7A was highly expressed in DLBCL, and its knockdown could inhibit DLBCL cell proliferation and metastasis, while promote cell cycle arrest and apoptosis. Similarly, FOXP1 also was upregulated in DLBCL, and its silencing could restrain the progression of DLBCL cells. 33830472 circCFL1 CircRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse regulation[CircCFL1/MiR-107 Axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Results showed that the circRNA CircCFL1 could regulate the expression of HMGB1 through miR-107 to promote the proliferation and migration of DLBCL. Yes After CircCFL1 was overexpressed, cell migration and proliferation were enhanced. The tumor volume and weight in the lentivirus CircCFL1 group were higher than those in the lentivirus NC group. 33061624 RP11-77H9.2 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[lower expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 RP11-732M18.3 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction[14-3-3β/α] Flow Cytometry//qRT-PCR//FISH Among these aberrantly expressed lncRNAs, lncRNA RP11-732M18.3 was over-expressed in glioma (2.53-fold change, p < .05) and consistently over-expressed in small group glioma tissues (data not show).Here, we describe the newly discovered noncoding RNA RP11-732M18.3, which is highly overexpressed in glioma cells and interacts with 14-3-3β/α to promote glioma growth, acting as an oncogene.Mechanistically, the interaction of lncRNA RP11-732M18.3 with 14-3-3β/α increases the degradation of the p21 protein. lncRNA RP11-732M18.3 promoted the recruitment of ubiquitin-conjugating enzyme E2 E1 to 14-3-3β/α and the binding of 14-3-3β/α with ubiquitin-conjugating enzyme E2 E1 (UBE2E1) promoted the degradation of p21. Yes Overexpression of lncRNA RP11-732 M18.3 was associated with the proliferation of glioma cells and tumor growth in vitro and in vivo. 31202814 RPL34-DT LncRNA Homo sapiens Glioma glioma tissues Regulation(ERK/AKT signaling) Western Blot//Transfection//Tube Formation Assay//Flow Cytometry//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay RPL34-AS1 was upregulated in glioma tissues and was correlated with tumor grade.RPL34-AS1 expression was also higher in glioma cells than in normal astrocytes. RPL34-AS1 expression was also higher in glioma cells than in normal astrocytes. Knockdown of RPL34-AS1 blocked glioma cell proliferation by inhibiting angiogenesis. This effect occurred through decreased ERK/AKT signaling. RPL34-AS1 was upregulated in glioma tissues and was correlated with tumor grade. Yes Knockdown of RPL34-AS1 blocked glioma cell proliferation by inhibiting angiogenesis. 34539892 RP11-2B6.2 LncRNA Homo sapiens Lupus Nephritis kidney tissues Interaction[IFN-I pathway] qRT-PCR//ELISA//Western Blot Elevated lncRNA RP11-2B6.2 was observed in kidney biopsies from LN patients and positively correlated with disease activity and IFN scores. Knockdown of LncRNA RP11-2B6.2 inhibited the phosphorylation of JAK1, TYK2, and STAT1 in IFN-I pathway, while promoted the chromatin accessibility and the transcription of SOCS1. Yes Knockdown of lncRNA RP11-2B6.2 in renal cells inhibited the expression of IFN stimulated genes (ISGs), while overexpression of lncRNA RP11-2B6.2 enhanced ISG expression. 31130957 RP11-390F4.3 LncRNA Homo sapiens Glioblastoma glioblastoma tissues Interaction(miR-148a/ROCK1 ) Western Blot//qPCR//Luciferase Report Assay//Migration Assay RP11-390F4.3 and ROCK1 were both upregulated in glioblastoma, while miR-148a was downregulated in glioblastoma.In glioblastoma, RP11-390F4.3 was positively correlated with ROCK1 but negatively correlated with miR-148a. Yes Cell invasion and migration analysis showed that overexpression of RP11-390F4.3 and ROCK1 resulted in increased, and overexpression of miR-148a resulted in deceased invasion and migration rates of glioblastoma cells. 34050115 RP11-386G11.10 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Interaction(ZBTB7A-RP11-386G11.10-HNRNPU positive feedback loop ) qRT-PCR RP11-386G11.10 was overexpressed in HCC and positively correlated with tumour size, TNM stage, and poor prognosis in HCC patients. Mechanistically, RP11-386G11.10 acted as a competing endogenous RNA (ceRNA) for miR-345-3p to regulate the expression of HNRNPU and its downstream lipogenic enzymes, leading to lipid accumulation in HCC cells and promoting their growth and metastasis. In addition, we identified ZBTB7A as a transcription factor of RP11-386G11.10. Moreover, HNRNPU promoted the expression of ZBTB7A in HCC cells, thereby increasing the transcriptional activity of RP11-386G11.10, and forming a positive feedback loop, ultimately leading continuous lipid accumulation, growth and metastasis in HCC cells. RP11-386G11.10 was overexpressed in HCC and positively correlated with tumour size, TNM stage, and poor prognosis in HCC patients. Yes RP11-386G11.10 promoted the proliferation and metastasis of HCC cells in vitro and in vivo. 35798238 RP11-363E7.4 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines interaction[p53, Bax/Bcl-2, β-catenin pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay The results showed that lncRNA RP11-363E7.4 was significantly downregulated in GC cell lines and 82 paired tissues. Western blot assay revealed that lncRNA RP11-363E7.4 functioned via the p53, Bax/Bcl-2, β-catenin pathway. The correlation between expression and clinicopathological features indicated that low expression of lncRNA RP11-363E7.4 was associated with T stage (P = .010). Yes Functional experiments showed that overexpression of lncRNA RP11-363E7.4 prevented proliferation, migration, and invasion and induced apoptosis of GC cells. 32141108 RP11-361F15.2 LncRNA Homo sapiens Osteosarcoma OS tissues regulation[RP11-361F15.2/miR-30c-5p/CPEB4 loop] qRT-PCR The results indicate that RP11-361F15.2 is significantly increased in OS tissues, and its expression is positively correlated with cytoplasmic polyadenylation element binding protein 4 (CPEB4) expression and negatively associated with miR-30c-5p expression.This RP11-361F15.2/miR-30c-5p/CPEB4 loop could be used as a potential therapeutic strategy for the treatment of OS. Yes Further, overexpression of RP11-361F15.2 increased OS cell migration/invasion and M2-Like polarization of TAMs in vitro, as well as promoted xenograft tumor growth in vivo. 31904478 RP11-357H14.17 LncRNA Homo sapiens Stomach Neoplasms gastric cancer patients Regulation(ATF2 signaling ) qRT-PCR//IHC We found that the high expression of RP11-357H14.17 was closely associated with shortened overall survival (OS) and poor prognosis in gastric cancer patients. Functional enrichment analysis revealed that RP11-357H14.17 is closely related to enhanced DNA replication and metabolism; ssGSEA analysis implied the oncogenic roles of RP11-357H14.17 was related to ATF2 signaling and Treg cell differentiation. We found that the high expression of RP11-357H14.17 was closely associated with shortened overall survival (OS) and poor prognosis in gastric cancer patients. We also found that its expression was related to clinical features including tumor volume, metastasis, and differentiation. Yes Functional enrichment analysis revealed that RP11-357H14.17 is closely related to enhanced DNA replication and metabolism; ssGSEA analysis implied the oncogenic roles of RP11-357H14.17 was related to ATF2 signaling and Treg cell differentiation. 34195276 RP11-323N12.5 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(c-MYC/ YAP) In Vivo Experiment//ChIP//Western Blot//ISH//Colony Formation Assay//CCK8//qRT-PCR//Migration Assay//Flow Cytometry//Luciferase Report Assay//ELISA//IHC//Invasion Assay//IF RP11-323N12.5 was the most up-regulated lncRNA in human GC, based on data from the TCGA database. Its transcription was significantly positively correlated with YAP1 transcription, YAP1 downstream gene expression which contribute to tumor growth and immunosuppression. RP11-323N12.5 promoted YAP1 transcription by binding to c-MYC in the YAP1 promoter region. Yes RP11-323N12.5 had tumor- and immnosuppression-promoting effects by enhancing YAP1 downstream genes in GC cells. Excessive RP11-323N12.5 was also observed in tumor-infiltrating leukocytes (TILs), which may be exosome-derived and also be related to enhanced Treg differentiation as a result YAP1 up-regulation. Moreover, RP11-323N12.5 promoted tumor growth and immunosuppression via YAP1 up-regulation in vivo. 32623586 RP11-315I20.1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[lower expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 RP11-301G19.1 LncRNA Homo sapiens Multiple Myeloma MM cell lines Interaction(miR-582-5p/HMGB2/PI3K/AKT signalling pathway) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay Our results demonstrated that RP11-301G19.1 was upregulated in MM cell lines and that its downregulation inhibited the proliferation and cell cycle progression and promoted the apoptosis of MM cells.Bioinformatic analysis and luciferase reporter assay results revealed that RP11-301G19.1 can upregulate the miR-582-5p-targeted gene HMGB2 as a competing endogenous RNA (ceRNA). Furthermore, Western blot results indicated that RP11-301G19.1 knockdown decreased the levels of PI3K and AKT phosphorylation without affecting their total protein levels. Yes Our results demonstrated that RP11-301G19.1 was upregulated in MM cell lines and that its downregulation inhibited the proliferation and cell cycle progression and promoted the apoptosis of MM cells. Additionally, in a xenograft model of human MM, RP11-301G19.1 knockdown significantly inhibited tumour growth by downregulating HMGB2. 33707625 RP11-286H15.1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC samples and cell lines regulation[ promoting PABPC4 ubiquitination] qRT-PCR//RNA Pull-Down//RIP//FISH The transcript abundance of RP11-286H15.1 in 80 pairs of HCC samples and cell lines was evaluated by qRT-PCR analysis.Our study demonstrates that a novel lncRNA, RP11-286H15.1, represses HCC progression by promoting PABPC4 ubiquitination. These findings highlight potential therapeutic targets for HCC. The qRT-PCR and FISH assays revealed that RP11-286H15.1 was significantly decreased in HCC, and implied a shorter survival time. Yes RP11-286H15.1 overexpression inhibited HCC cell proliferation and metastasis in vitro and in vivo, whereas RP11-286H15.1 knockdown produced the opposite results. 33259899 RP11-40C6.2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC patients and cell line Regulation(Hippo signaling pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transwell Assay//Co-IP//CCK8//qRT-PCR//migration assay//Luciferase Report Assay//IHC//Bioinformatics Analysis//ChIP RP11-40C6.2 was overexpressed in HCC patients with HBV infection compared to those without HBV infection. Luciferase gene reporter and ChIP assays revealed that YAP1/TAZ/TEADs complex enhanced RP11-40C6.2 transcription by binding to its promoter area. RP11-40C6.2 showed oncogenic characteristics in HCC cell lines and in animal models that were mediated via activation of YAP1. In vitro ubiquitylation assay revealed that RP11-40C6.2 can promote the stabilization of YAP1 by stopping phosphorylation at its s127 residue and further stopping its degradation through binding to 14-3-3. Yes Luciferase gene reporter and ChIP assays revealed that YAP1/TAZ/TEADs complex enhanced RP11-40C6.2 transcription by binding to its promoter area. RP11-40C6.2 showed oncogenic characteristics in HCC cell lines and in animal models that were mediated via activation of YAP1. In vitro ubiquitylation assay revealed that RP11-40C6.2 can promote the stabilization of YAP1 by stopping phosphorylation at its s127 residue and further stopping its degradation through binding to 14-3-3. 36643034 RP11-283G6.5 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(miR-188-3p/TMED3/Wnt/β-catenin signalling) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//IF//Luciferase Report Assay//IHC//Invasion Assay//Transwell Assay In this study, we identified a novel lncRNA RP11-283G6.5 which was lowly expressed in breast cancer and whose low expression was correlated with poor overall survival and disease-free survival of breast cancer patients. Collectively, these findings demonstrated that RP11-283G6.5 is a tumour suppressive lncRNA in breast cancer via modulating miR-188-3p/TMED3/Wnt/β-catenin signalling. This study indicated that RP11-283G6.5 might be a promising prognostic biomarker and therapeutic target for breast cancer. In this study, we identified a novel lncRNA RP11-283G6.5 which was lowly expressed in breast cancer and whose low expression was correlated with poor overall survival and disease-free survival of breast cancer patients.  Yes Functional experiments revealed that ectopic expression of RP11-283G6.5 confined breast cancer cellular growth, migration, and invasion, and promoted cellular apoptosis. Conversely, RP11-283G6.5 silencing facilitated breast cancer cellular growth, migration, and invasion, and repressed cellular apoptosis. Moreover, RP11-283G6.5 was found to confine breast cancer tumour growth and metastasis in vivo. 34130584 RP11-279C4.1 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-1273g-3p/CBX3 Axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay In the present study, we identified and verified the expression of the novel lncRNA RP11-279C4.1 by analyzing the TANRIC database and performing qRT-PCR assays, the results of which revealed its upregulation in glioma tissues and cell lines. Mechanistically, RP11-279C4.1 induced CBX3 activation via competitively sponging miR-1273g-3p, and rescue assay results confirmed the importance of the RP11-279C4.1/miR-1273g-3p/CBX3 axis. Yes The results of multiple functional experiments demonstrated that RP11-279C4.1 knockdown inhibited glioma malignant phenotypes, including cell proliferation, migration, invasion and cell self-renew ability in vitro. In addition, RP11-279C4.1 downregulation suppressed tumour growth in vivo. 33694060 RP11-264B17.2 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 RP11-259O2.3 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[lower expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 circMTUS1 CircRNA Homo sapiens malignant conjunctival melanoma conjunctival melanoma tissues Interaction[binding to hsa-miR-622 and hsa-miR-1208 ] RIP//RNA-seq We identified 9300 different circRNAs in conjunctival melanoma tissues compared with adjacent normal tissues.CircMTUS1 was Expression[Expression[up-expression]-expression]regulated in conjunctival melanoma.CircMTUS1 may serve as an oncogene by binding to hsa-miR-622 and hsa-miR-1208 to regulate several tumor-related pathways. Yes Silencing of circMTUS1 inhibited conjunctival melanoma proliferation in vitro and in vivo. 30892069 RP11-214F16.8 LncRNA Homo sapiens Breast Neoplasms breast cancer patients Expression(highly expressed) RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//Co-IP//qRT-PCR//RIP//FISH//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Invasion Assay//Transwell Assay We identified that up-regulation of the lncRNA RP11-214F16.8 is subtype-independently associated with a higher overall death rate in breast cancer patients. Mechanistically, the oncogenic property of RP11-214F16.8 lies to its post-translational repression on the tumor suppressor NISCH via recruiting SENP3-mediated de-SUMOylation and ubiquitin-proteasome-mediated protein degradation. NISCH in turn inhibits the transcription of RP11-214F16.8 through restraining the expression of the transcription factors located downstream of RAC1, PAK1 and ERK1/2 signaling transduction pathways. Yes Increased RP11-214F16.8 expression endows breast cancer cells enhanced capabilities in the aspects of proliferation, invasion, migration and tumor-initiation, while loss of the lncRNA exerts the opposite effects. 35108640 hsa_circ_0070934 CircRNA Homo sapiens Cutaneous Squamous CSCC and matched normal tissues Interaction[miR-1238 and miR-1247-5p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The quantification data revealed that circ_0070934 was significantly overexpressed in a large subset of CSCC specimens when compared with their paired normal specimens (Fig. 1A). Circ_0070934 expression was negatively correlated with miR-1238 and miR-1247-5p expression in CSCC and luciferase reporter experiment verified the binding ability between circ_0070934 and miR-1238/miR-1247-5p. Rescue experiments further identified that the oncogenic role of circ_0070934 is attributed to its sExpression[Expression[up-expression]-expression]pression of miR-1238 and miR-1247-5p. Yes Loss-of-function and gain-of-function assays were performed to detect cell proliferation, apoptosis, migration and invasion in vitro. 30967263 RP11-395G23.3 LncRNA Homo sapiens Endometrial Neoplasms EC tissues regulation[microRNA-205-5p/PTEN axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Transwell Assay We discovered that low RP11-395G23.3 expression was significantly related to advanced histological grade and lymphovascular space invasion in EC patients. We demonstrated for the first time that RP11-395G23.3 may inhibit the development and pathogenesis of EC by acting as a sponge for miRNA-205-5p and increasing PTEN expression. RP11-395G23.3 may be a target for the diagnosis and treatment of EC. We discovered that low RP11-395G23.3 expression was significantly related to advanced histological grade and lymphovascular space invasion in EC patients. Yes In addition, overexpression of RP11-395G23.3 significantly inhibited the proliferation, invasion, migration, and induced apoptosis of Ishikawa and HEC-1A cells in vitro. 32913516 RP11-422N16.3 LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma cancer tissues and cells Interaction[Sponging miR-23b-3p] RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Expressions of RP11-422N16.3 and DMGDH were down-regulated while that of miR-23b-3p were up-regulated in hepatocellular carcinoma cancer tissues and cells.Our data suggested that LncRNA RP11-422N16.3, by competitively binding to miR-23b-3p, promoted DMGDH expression, contributing to inhibit cell proliferation and EMT, and induce cell apoptosis in hepatocellular carcinoma cells. Yes Up-regulation of RP11-422N16.3 and down-regulation of miR-23b-3p contributed to increased expressions of DMGDH and E-cadherin, and decreased expressions of miR-23b-3p, ZEB1, Snail and Vimentin, resulting in inhibiting cell proliferation and promoting cell apoptosis. 31849497 RP11-732M18.3 LncRNA Homo sapiens Glioma endothelial cell Regulation(EP300/VEGFA) Western Blot//Transfection//Co-IP//qRT-PCR//migration assay//H&E Staining//IHC//IF lncRNA RP11-732M18.3 increased CD31+ microvessel density, and overexpression of lncRNA RP11-732M18.3 resulted in poor mouse survival. lncRNA RP11-732M18.3 promoted endothelial cell migration and tube formation. Mechanistically, lncRNA RP11-732M18.3 promotes angiogenesis by increasing the nuclear level of EP300 and facilitating the transcription and secretion of VEGFA. Our study contributes to the latest understanding of glioma angiogenesis and prognosis. lncRNA RP11-732M18.3 may be a potential treatment target in glioma. Yes lncRNA RP11-732M18.3 increased CD31+ microvessel density, and overexpression of lncRNA RP11-732M18.3 resulted in poor mouse survival. lncRNA RP11-732M18.3 promoted endothelial cell migration and tube formation. 35785190 RP11-59J16.2 LncRNA Homo sapiens Alzheimer Disease SH-SY5Y cells, AD patients Interaction(MCM2 ) qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Western Blot The result showed that RP11-59J16.2 was up-regulated and MCM2 was down-regulated in serum of AD patients. Dual luciferase reporter gene analysis verified that RP11-59J16.2 could directly interact with 3'UTR of MCM2 and further regulate the expression of MCM2. Yes Inhibition of RP11-59J16.2 or overexpression of MCM2, CCK-8 assay and Annexin V FITC/PI apoptosis assay kit results showed that RP11-59J16.2 could reduce cell viability, aggravate apoptosis and increase Tau phosphorylation in AD cell model by inhibiting MCM2. 36092938 RP11-705C15.3 LncRNA Homo sapiens Melanoma melanoma tissues regulation[RP11-705C15.3/miR-145-5p/NRAS/MAPK signaling axis] Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay Furthermore, we investigated the expression of RP11-705C15.3 in clinical melanoma tissues and found that RP11-705C15.3 was increased in melanoma tissues. Taken together, our findings suggest RP11-705C15.3 as a novel oncogene in melanoma, and highlight that the RP11-705C15.3/miR-145-5p/NRAS/MAPK signaling axis may be potential therapeutic targets for melanoma. High expression of RP11-705C15.3 was positively correlated with thickness, ulceration, metastasis, and inferior overall survival. Yes Silencing of RP11-705C15.3 repressed melanoma cell proliferation, induced apoptosis, and repressed migration and invasion. 33311650 RP1-163G9.1 LncRNA Homo sapiens gastric adenocarcinoma GA tissues and cell lines Expression[lower expressed] Western Blot//CCK8//qRT-PCR//FISH//Colony Formation Assay//Transwell Assay lncRNA RP1‑163G9.1 expression in GA tissues and cells was significantly decreased when compared with that in control gastric tissues (P<0.001) or gastric epithelial cells GES‑1 (P<0.05). lncRNA RP1‑163G9.1 expression in GA tissues and cells was significantly decreased when compared with that in control gastric tissues (P<0.001) or gastric epithelial cells GES‑1 (P<0.05). This finding was associated with the depth of invasion (P=0.001), lymph node metastasis (P=0.009), tumor size (P=0.037) and immunocytochemistry marker Ki‑67 (P=0.010). Yes Notably, overexpression of lncRNA RP1‑163G9.1 significantly decreased cell proliferation (P<0.01), colony formation (P<0.01), invasion (P<0.01) and the number of cells at the S‑phase of the cell cycle (P<0.05); However, it did not exert a significant effect on apoptosis (P>0.05). Furthermore, tumor formation experiments revealed that overexpression of lncRNA RP1‑163G9.1 inhibited cancer cell proliferation in nude mice. 31002370 RP11-63A11.1 LncRNA Homo sapiens Carcinoma, Renal Cell pRCC cells and tissues Expression(lower expressed) Cell Proliferation Assay//qRT-PCR//Cell Apoptosis Assay//Western Blot RP11-63A11.1 was mainly expressed in renal tissues and it correlated with the tumor stage, T, M, N classifications, OS, PFS, and DSS of pRCC patients. Consistent with the expression in pRCC tissue samples, RP11-63A11.1 was also down-regulated in pRCC cells. RP11-63A11.1 was mainly expressed in renal tissues and it correlated with the tumor stage, T, M, N classifications, OS, PFS, and DSS of pRCC patients. Consistent with the expression in pRCC tissue samples, RP11-63A11.1 was also down-regulated in pRCC cells. Yes More importantly, up-regulation of RP11-63A11.1 attenuated cell survival and induced apoptosis. 34663322 RP11-626G11.3 LncRNA Homo sapiens Glioma glioma tissues and cell lines regulation[miR-375-SP1 axis] qRT-PCR Results indicated that lncRNA RP11-626G11.3 was up-regulated in glioma tissues and cell lines, moreover, its overexpression positively correlated with the poor prognosis and advanced pathological stages.Overall, our study shows that lncRNA RP11-626G11.3 promotes glioma progression by sponging miR-375 to regulate SP1 expression, which may provide a novel therapeutic strategy for glioma. Results indicated that lncRNA RP11-626G11.3 was up-regulated in glioma tissues and cell lines, moreover, its overexpression positively correlated with the poor prognosis and advanced pathological stages. Yes Gain and loss of functional experiments demonstrated that lncRNA RP11-626G11.3 promoted the proliferation and invasion of glioma cells in vitro. The knockdown of lncRNA RP11-626G11.3 repressed the tumor growth in vivo. 32128886 RP11-624L4.1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues regulation[CDK4/6-Cyclin D1-Rb-E2F1 Pathway] ISH//qRT-PCR//RIP As a result, we found that RP11-624L4.1 is hyper-expressed in NPC tissues, which was associated with unfavorable prognosis and clinicopathological features in NPC.Taken together, RP11-624L4.1 is required for NPC unfavorable prognosis and proliferation through the CDK4/6-Cyclin D1-Rb-E2F1 pathway, which may be a novel therapeutic target and prognostic in patients with NPC. As a result, we found that RP11-624L4.1 is hyper-expressed in NPC tissues, which was associated with unfavorable prognosis and clinicopathological features in NPC. Yes By knocking down and overexpressing RP11-624L4.1, we also found that it promotes the proliferation ability of NPC in vitro and in vivo through the CDK4/6-Cyclin D1-Rb-E2F1 pathway. 33078086 RP11-619L19.2 LncRNA Homo sapiens Colonic Neoplasms CC tissues and cell lines regulation[miR-1271-5p/CD164 axis] Western Blot//Migration Assay//CCK8//qRT-PCR//Invasion Assay RP11?619L19.2 was found to be highly expressed in CC tissues and cell lines, and it was associated with advanced TNM stage and lymph node metastasis.In conclusion, the findings of the present study indicated that RP11‑619L19.2 regulates CD164 expression and EMT by sponging miR‑1271‑5p, which may provide novel targets for lncRNA‑directed diagnosis and therapy for patients with CC. RP11?619L19.2 was found to be highly expressed in CC tissues and cell lines, and it was associated with advanced TNM stage and lymph node metastasis. Yes Furthermore, knockdown of RP11?619L19.2 inhibited CC cell proliferation, migration, invasion and epithelial?to?mesenchymal transition (EMT). 33125110 RP11-603J24.7 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[lower expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 RP11-59H7.3 LncRNA Homo sapiens Colorectal Neoplasms regulation[miR-139-5p/NOTCH1 axis] qRT-PCR//Luciferase Report Assay Taken together, these results demonstrated that the RP11-59H7.3/miR-139-5p/NOTCH1 axis functions as a key regulator in CRC metastasis. RP11-59H7.3 represents a potential biomarker for CRC diagnosis and could be an important target for development of novel therapies to manage the disease. Yes Functional analyses of this lncRNA revealed its role in promoting proliferation and progression of the cell cycle, as well as enhancement of cell migration and invasion. 32507766 RP11-443B7.1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 RP11-569A11.1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Expression(lower expressed) qRT-PCR//Colony Formation Assay//Western Blot Of which, RP11-569A11.1 was found to be significantly downregulated in CRC tissues and cells. Yes Functionally, overexpression of RP11-569A11.1 inhibited CRC cell proliferation, migration and invasion, and induced cell apoptosis, while knockdown of RP11-569A11.1 generated an opposite effect. 33942366 RP11-552M11.4 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and corresponding non-tumor tissues Regulation[miR-3941/ATF1 signaling ] Migration Assay//RIP//qRT-PCR//FISH//Luciferase Report Assay//Invasion Assay Our results demonstrated that the expression of lncRNA RP11-552M11.4 was markedly increased in cervical cancer tissues compared with the adjacent non-tumor tissues.Our observations elucidated the carcinogenic role of lncRNA RP11-552M11.4 in CC was mediated through miR-3941/ATF1 axis, giving a new insight into the effective target for the treatment and prognosis of cervical cancer. Additionally, CC patients with high lncRNA RP11-552M11.4 level suffered from poor clinical outcomes. Yes Moreover, silenced lncRNA RP11-552M11.4 restrained cell proliferation, migration and invasion in CC cells. 30790638 RP11-552D4.1 LncRNA Homo sapiens Glioblastoma glioblastoma tissues and cell Regulation CCK8 The RP11-552D4.1 is found to facilitate neuronal proliferation. Yes The RP11-552D4.1 is found to facilitate neuronal proliferation. 35852867 RP11-551L14.4 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(miR-4472) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay The results of qRT-PCR showed that RP11-551L14.4 expression in breast cancer tissues was significantly lower than in adjacent tissues. Bioinformatics technology showed that RP11-551L14.4 could complementarily bind to miR-4472. qRT-PCR results indicated that the expression levels of miR-4472 and RP11-551L14.4 in breast cancer were negatively correlated. RP11-551L14.4 expression was negatively associated with the advanced tumor stage. Breast cancer patients with low RP11-551L14.4 expression manifested a poorer prognosis. Yes Meanwhile, overexpression of RP11-551L14.4 significantly decreased the cell proliferation and cell cycle. 36523479 RP11-51O6.1 LncRNA Homo sapiens Colorectal Neoplasms six CRC tissues and three adjacent non-tumor tissues Interaction(miR-206/YAP1) RNA Pull-Down//Western Blot//ISH//qRT-PCR//Luciferase Report Assay//IHC In this context, we explored the differentially expressed profiles of lncRNAs in six CRC tissues and three adjacent non-tumor tissues from RNA-sequencing (RNA-seq) study and noted a lncRNA, RP11-51O6.1, which is markedly overexpressed in CRC tissues, particularly in aggressive cases. Mechanistic studies (Bioinformatics binding site analyses, the Luciferase reporter, Ago2 immunoprecipitation, the RNA pull-down, immunofluorescence colocalization, rescued assays and western blotting) implicated that RP11-51O6.1 could regulate YAP1 expression by competitively sponging miR-206 and blocking its activity in promoting CRC progression. Impressively, an elevated RP11-51O6.1 level was highly correlated with poor prognosis in clinical patients. Yes Functional analyses revealed that RP11-51O6.1 could promote cell proliferation in vitro and in vivo. Furthermore, we reported that RP11-51O6.1 enhances cell migration and invasion in vitro. 34038520 RP11-499E18.1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(PAK2-SOX2 Interaction) qRT-PCR//RNA Pull-Down//Western Blot RP11-499E18.1 was downregulated, while PAK2 and SOX2 was upregulated in OC tissues and cells. There is an interaction between RP11-499E18.1 and PAK2, as well as PAK2 and SOX2 in OC cells. Alteration of RP11-499E18.1 and PAK2 expression both had no influence on PAK2 and SOX2 levels, but PAK2 upregulation notably augmented p-SOX2 level. Additionally, RP11-499E18.1 overexpression reduced PAK2-SOX2 interaction and SOX phosphorylation, and increased the binding of RP11-499E18.1 by PAK2. Yes RP11-499E18.1 overexpression suppressed OC cell proliferation, migration, and colony formation, as well as SOX2 nuclear translocation. Besides, it inhibited tumor growth in nude mice. However, these effects were notably reversed by PAK2 upregulation and eventually offset by SOX2 knockdown. 34621737 RP11-468E2.5 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[JAK/STAT signaling pathway] qRT-PCR CRC tissues showed lower expression of RP11-468E2.5, higher expression of STAT5, STAT6 and of the cell cycle marker Cyclin D1 (CCND1), compared to the findings in adjacent normal tissues. The treatment of siRNA against RP11-468E2.5 increased expression of JAK2, STAT3, STAT5, STAT6, CCND1 and Bcl-2 along with the extent of STAT3, STAT5 and STAT6 phosphorylation, while lowering expression of P21 and P27. Yes Treatment with AG490 exhibited approximately opposite effects, whereas siRNA against RP11-468E2.5 treatment stimulated CRC cell proliferation and reduced cell apoptosis, while promoting cell cycle entry; AG490 treatment reversed these results. 31718693 RP11-465B22.8 LncRNA Homo sapiens Esophageal Neoplasms EC tissues Interaction(miR-765/KLK4 axis) qRT-PCR//Western Blot LncRNA RP11-465B22.8 was upregulated in EC tissues and high lncRNA RP11-465B22.8 expression was associated with poor survival of EC patients. Mechanistically, lncRNA RP11-465B22.8 sponged miR-765 to increase the expression of KLK4. LncRNA RP11-465B22.8 was upregulated in EC tissues and high lncRNA RP11-465B22.8 expression was associated with poor survival of EC patients. Yes Ectopic expression of lncRNA RP11-465B22.8 enhanced the proliferation, migration, and invasion of EC cells, whereas knockdown of lncRNA RP11-465B22.8 led to the opposite effects. 34561425 RPL34-DT LncRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissue, cell line(TE-1, TE-13, KYSE150 and KYSE450 , Het-1A) Interaction[RPL34 ] CCK8//qRT-PCR//Transwell Assay In our study, we found RPL34-AS1 expression levels in esophageal cancer tissue and specimens and cell lines were lower than in adjacent normal tissue specimens and normal esophageal cell line, respectively.In survival analysis suggested esophageal cancer patients with low RPL34-AS1 expression had short overall survival than those with high RPL34-AS1 expression. Our in vitro experiments suggested RPL34-AS1 inhibits esophageal cancer cell proliferation, migration and invasion through Expression[down-expression]-regulating RPL34 expression. In conclusion, RPL34-AS1 functions as tumor sExpression[Expression[up-expression]-expression]pressor in esophageal cancer. "For investigating the clinical significance of RPL34-AS1 in esophageal cancer patients, total 56 esophageal cancer cases in our study were divided into two groExpression[Expression[up-expression]-expression]s based on clinicopathological features including clinical stage (Ⅰ-Ⅱ vs. Ⅲ-Ⅳ), T classification (T1-T2 vs. T3-T4) and lymph node metastasis (Negative vs. Positive). As shown in the Fig. 2A–C, esophageal cancer patients with Ⅲ-Ⅳ, T3-T4 or positive lymph node metastasis had lower RPL34-AS1expression levels than esophageal cancer patients with Ⅰ-Ⅱ, T1-T2 or negative lymph node metastasis, respectively. " Yes CCK-8 assay was used to investigate the effect of RPL34-AS1 on esophageal cancer cell proliferation. As shown in Fig. 5A, RPL34-AS1 overexpression profoundly inhibited esophageal cancer cell proliferation at 72 h and 120 h. 31574377 SCARNA10 LncRNA Homo sapiens Liver Cirrhosis liver tissues,blood Interaction[ ECM and TGFβ pathway] RIP//ChIP It was found lncRNA ENSMUST00000158992, named as Scarna10, was remarkably up-regulated in mouse fibrotic livers according to the microarray data. We observed that the transcript of SCARNA10 was increased in the serum and liver from patients with advanced hepatic fibrosis.Mechanistically, RNA immunoprecipitation (RIP) assays demonstrated that SCARNA10 physically associated with polycomb repressive complex 2 (PRC2). Additionally, our results demonstrated that SCARNA10 functioned as a novel positive regulator of TGFβ signaling in hepatic fibrogenesis by inhibiting the binding of PRC2 to the promoters of the genes associated with ECM and TGFβ pathway, thus promoting the transcription of these genes. Yes Furthermore, we found that SCARNA10 promoted liver fibrosis both in vitro and in vivo through inducing hepatocytes (HCs) apoptosis and HSCs activation. 31281502 SAP30-2:1 LncRNA Homo sapiens Heart Defects, Congenital CHD Interaction(HAND2) Western Blot//Transfection//qPCR//CCK8//RIP//Cell Apoptosis Assay//EdU Staining We used Gene Expression Omnibus data mining, bioinformatics analysis, and analysis of clinical tissue samples and observed that the novel lncRNA SAP30-2:1 with unknown function was significantly downregulated in damaged cardiac tissues from patients with CHD. Moreover, lncRNA SAP30-2:1 was associated with HAND2 by RNA immunoprecipitation. Yes Knockdown of lncRNA SAP30-2:1 inhibited the proliferation of human embryonic kidney and AC16 cells and decreased the expression of heart and neural crest derivatives expressed 2 (HAND2). 32820380 SBF2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-520a-3p) Transfection//CCK8//RIP//qRT-PCR//Luciferase Report Assay//Transwell Assay In NSCLC tissues, SBF2-AS1 was highly expressed, while miR-520a-3p expression has decreased. More importantly, the suppression of SBF2-AS1 silencing on the proliferation, migration, and invasion in NSCLC cells was counteracted by miR-520a-3p inhibition. The overall survival of NSCLC patients with high SBF2-AS1 expression was lower. Yes SBF2-AS1 silencing repressed the proliferation, migration, and invasion of NSCLC cells. SBF2-AS1 directly interacted with miR-520a-3p, and a negative relationship was observed between their expression levels in NSCLC tissues. 35444785 SBF2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma Interaction(miR-362-3P/E2F1 axis ) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//qPCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay It was further found that the higher the expression of SBF2-AS1, the lower the survival rate.In mechanism, SBF2-AS1/miR-338-3P, miR-362-3P/E2F1 axis are involved in the regulation of ESCC growth. It was further found that the higher the expression of SBF2-AS1, the lower the survival rate.COX multivariate analysis showed that the expression of SBF2-AS1 was an independent prognostic factor. Yes Functional experiments show that inhibition of SBF2-AS1 can inhibit the proliferation of ESCC through in vivo and in vitro, and overexpression of SBF2-AS1 can promote the proliferation of ESCC and inhibit its apoptosis. 33436941 SBF2-AS1 LncRNA Homo sapiens Aortic Aneurysm, Abdominal VSMCs Interaction(miRNA-520f-3p/SMARCD1 Axis) qRT-PCR//Transfection//RNA Pull-Down//Western Blot SBF2-AS1 enhances SMARCD1 expression by forming miR-520f-3p in VSMC and HASMC. Overexpression of SMARCD1 or miR-520f-3p inhibitor reversed cell viability and caspase-3 activity mediated by SBF2-AS1 depletion in VSMC and HASMC. Yes Depletion of SBF2-AS1 enhanced the cell viability and proliferation of VSMCs. Conversely, SBF2-AS1 knockdown inhibited VSMC apoptosis. Caspase-3 activity was inhibited by depletion of SBF2-AS1, whereas overexpression of SBF2-AS1 in VSMC promoted Caspase-3 activity. 35968497 SBF2-AS1 LncRNA Homo sapiens Ovarian Neoplasms SOC tissues Interaction(microRNA-338-3p) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay In this study, the aberrant upregulation of SBF2-AS1 is detected in SOC after analysis of differentially expressed genes between SOC tissues and normal fallopian tubes from the public Gene Expression Omnibus (GEO) database. MiR-338-3p acts as a tumor suppressor in SOC, and E26 transformation specific-1 (ETS1) is identified as a potential target of miR-338-3p regulation. Furthermore, SBF2-AS1 could modulate ETS1 by operating as a competing endogenous RNA for miR-338-3p. Yes We determine that knockdown of SBF2-AS1 inhibits SOC cell proliferation and invasion by sponging miR-338-3p. 34850542 SATB2-AS1 LncRNA Homo sapiens Colorectal Neoplasms colorectal tissues Interaction[regulating SATB2] ISH//qRT-PCR//RIP//ChIP SATB2-AS1 is specifically expressed in colorectal tissues and downregulated in CRC. Mechanistically, SATB2-AS1 directly binds to WDR5 and GADD45A, cis-activating SATB2 (Special AT-rich binding protein 2) transcription via mediating histone H3 lysine 4 tri-methylation (H3K4me3) deposition and DNA demethylation of the promoter region of SATB2. Survival analysis indicates that decreased SATB2-AS1 expression is associated with poor survival. Yes Functional experiments and bioinformatics analysis revealed that SATB2-AS1 inhibits CRC cell metastasis and regulates TH1-type chemokines expression and immune cell density in CRC. 31492160 SATB2-AS1 LncRNA Homo sapiens Colorectal Neoplasms colorectal carcinoma cells and tissues Regulation[SATB2-Snail axis] RNA Pull-Down//ISH//qRT-PCR//RIP//Microarray//ChIP SATB2-AS1 was frequently downregulated in colorectal carcinoma cells and tissues. SATB2-AS1 suppressed colorectal carcinoma progression by serving as a scaffold to recruit p300, whose acetylation of H3K27 and H3K9 at the SATB2 promoter upregulated expression of SATB2, a suppressor of colorectal carcinoma growth and metastasis. SATB2 subsequently recruited HDAC1 to the Snail promoter, repressing Snail transcription and inhibiting epithelial-to-mesenchymal transition. Taken together, these data reveal SATB2-AS1 as a novel regulator of the SATB2-Snail axis whose loss facilitates progression of colorectal carcinoma. SIGNIFICANCE: These data show that the lncRNA SATB2-AS1 mediates epigenetic regulation of SATB2 and Snail expression to suppress colorectal cancer progression. SATB2-AS1 was frequently downregulated in colorectal carcinoma cells and tissues, and patients whose tumors expressed SATB2-AS1 at low levels had a shorter overall survival and poorer prognosis. Yes Downregulation of SATB2-AS1 significantly promoted cell proliferation, migration, and invasion in vitro and in vivo, demonstrating that it acts as a tumor suppressor in colorectal carcinoma. 30858153 SAP30L-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues and cell lines Interaction[repressing SAP30L] CCK8//qRT-PCR//Western Blot The expression of SAP30L-AS1 is found to be increased in prostate cancer tissues and cell lines compared with adjacent noncancerous tissues and normal prostate epithelial cell line, respectively. Mechanistic investigation revealed that SAP30L-AS1 physically binds to the promoter of SAP30L and represses SAP30L expression. The expression of SAP30L is negatively associated with that of SAP30L-AS1 in prostate cancer tissues. Rescue assays demonstrated that overexpression of SAP30L attenuated the roles of SAP30L-AS1 in promoting prostate cancer proliferation and inhibiting prostate cancer apoptosis. In conclusion, SAP30L-AS1 is upregulated and has oncogenic roles in prostate cancer via repressing SAP30L. Our data suggest that SAP30L-AS1 may be a promising prognostic biomarker and therapeutic target for prostate cancer. Increased expression of SAP30L-AS1 is associated with greater Gleason score, advanced pathological T stage, and poor over survival of prostate cancer patients. Yes Functional assays demonstrated that ectopic expression of SAP30L-AS1 promotes prostate cancer proliferation and inhibits prostate cancer apoptosis. SAP30L-AS1 knockdown represses prostate cancer proliferation and induces prostate cancer apoptosis. Furthermore, SAP30L-AS1 knockdown represses prostate cancer xenograft growth in vivo. 30599235 SAMMSON LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Expression[highly expressed] qRT-PCR//Wound Healing Assay//Transwell Assay QRT-PCR results showed that lncRNA-SAMMSON was abnormally overexpressed in GC tissues and cells (p<0.05). Kaplan-Meier survival analysis represented that GC patients with high lncRNA-SAMMSON expression had significantly shorter progression-free survival time and overall survival time (p<0.05). Yes Transwell assay and wound healing assay proved that inhibition of lncRNA-SAMMSON in GC cells dramatically reduced the invasion and migration abilities of GC cells, respectively (p<0.05). 32572923 SBF2-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung Regulation[SBF2-AS1-miR-338-3p/362-3p-E2F1 regulatory axis ] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//RNA-seq Five early LUAD-specific lncRNAs were filtered out, and only SBF2-AS1 was upregulated in LUAD. The SBF2-AS1-miR-338-3p/362-3p-E2F1 regulatory axis may serve as a prognostic marker and potential therapeutic target for LUAD. High expression of SBF2-AS1 indicates poor survival of LUAD, especially the early-stage LUAD, but not lung squamous cell carcinoma. Yes SBF2-AS1 promotes LUAD cells proliferation in vitro, and RNA-sequencing data shows that many cell-cycle-related genes were downregulated after SBF2-AS1 knockdown. 31071530 SAMMSON LncRNA Homo sapiens Thyroid Cancer, Papillary PTC cells, tissues, and plasma Regulation[p300/Sp1 axis] qRT-PCR SAMMSON was identified to be notably upregulated in PTC cells, tissues, and plasma, and could be used as an effective diagnostic and prognostic biomarker for PTC patients. Mechanistically, SAMMSON was transcriptionally elevated by oncogenic Sp1, in turn, upregulated SAMMSON was capable of acting as a scaffold to recruit p300 to increase H3K9ac and H3K27ac levels on Sp1 promoter region, leading to transcriptional activation of Sp1, thereby facilitating PTC progression. Taken together, our data demonstrate that SAMMSON is an oncogenic lncRNA and unveil the crucial role of SAMMSON/Sp1 positive feedback loop in tumorigenesis and aggressiveness of PTC. Yes Knockdown of SAMMSON significantly inhibited PTC cell proliferation and invasion in vitro as well as tumorigenicity and metastasis in vivo. 31478331 SAMMSON LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[regulates miR-9-3p ] qRT-PCR We found that SAMMSON was up-regulated in HCC tissues, and patients with high levels of SAMMSON in HCC tissues had significantly lower overall rate within 5 years after admission. We found that SAMMSON was up-regulated in HCC tissues, and patients with high levels of SAMMSON in HCC tissues had significantly lower overall rate within 5 years after admission. Yes SAMMSON overexpression led to increased, while miR-9-3p overexpression resulted in decreased migration and invasion rates of HCC cells. 31164410 SAMMSON LncRNA Homo sapiens Glioblastoma GBM tissues and cells regulation[PI3K/Akt Pathway] CCK8//qRT-PCR//Western Blot We found that SAMMSON was highly expressed in GBM tissues and cells. Taken together, lncRNA SAMMSON knockdown inhibited the malignancy of GBM cells by inactivation of the PI3K/Akt pathway. Yes Moreover, SAMMSON silencing impeded the invasive ability of GBM cells by regulating epithelial-to-mesenchymal transition (EMT). 32236901 SAMMSON LncRNA Homo sapiens Uveal melanoma uveal melanoma cell lines Regulation Bioinformatics Analysis Antisense oligonucleotide (ASO)-mediated SAMMSON inhibition impaired the growth and viability of a genetically diverse panel of uveal melanoma cell lines. These effects were accompanied by an induction of apoptosis and were recapitulated in two uveal melanoma patient derived xenograft (PDX) models through subcutaneous ASO delivery. Yes Antisense oligonucleotide (ASO)-mediated SAMMSON inhibition impaired the growth and viability of a genetically diverse panel of uveal melanoma cell lines. These effects were accompanied by an induction of apoptosis and were recapitulated in two uveal melanoma patient derived xenograft (PDX) models through subcutaneous ASO delivery. 34508176 SAMD12-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cell lines Interaction( DNMT1/p53 Axis) Western Blot//CCK8//qRT-PCR//FISH//RIP//Transwell Assay//IF SAMD12-AS1 was highly up-regulated in human gastric cancer tissues and cell lines compared to their normal counterparts. Mechanistically, SAMD12-AS1 might performed its biological roles in GC via directly interacting with DNMT1 and facilitating DNMT1 repress the P53 signaling pathway. High SAMD12-AS1 expression was closely related to TNM stage, and shorter survival span of patients with GC. Yes Moreover, SAMD12-AS1 was also found to promote the oncogenic role of GC cells via inhibiting the P53 signaling pathway. 33962804 SAMD12-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular tumor tissues Regulation(p53 Signaling Pathway) CCK8//qRT-PCR The level of lncRNA SAMD12-AS1 expression in tumor tissues was remarkably higher than that in paracancerous liver tissues (p < 0.01). It was found that the lncRNA SAMD12-AS1 expression was largely correlated with TNM stage of tumor, vascular invasion, and hepatitis B surface (HBs) antigen in liver cancer patients (p < 0.05). Cell function experiments showed that lncRNA SAMD12-AS1 overexpression promoted liver cancer development, migration, and invasion (p < 0.05), while lncRNA SAMD12-AS1 knockdown inhibited the activity of liver cancer cells to invade and migrate (p < 0.05). Western blot analysis showed that overexpression of lncRNA SAMD12-AS1 markedly inhibited p21, p53, and E-cadherin expression and promoted vimentin expression. Conversely, knockdown of lncRNA SAMD12-AS1 significantly promoted p21, p53, and E-cadherin expression and inhibited vimentin expression (p < 0.05). It was found that the lncRNA SAMD12-AS1 expression was largely correlated with TNM stage of tumor, vascular invasion, and hepatitis B surface (HBs) antigen in liver cancer patients (p < 0.05). Yes Cell function experiments showed that lncRNA SAMD12-AS1 overexpression promoted liver cancer development, migration, and invasion (p < 0.05), while lncRNA SAMD12-AS1 knockdown inhibited the activity of liver cancer cells to invade and migrate (p < 0.05). Western blot analysis showed that overexpression of lncRNA SAMD12-AS1 markedly inhibited p21, p53, and E-cadherin expression and promoted vimentin expression. 36052283 SAMD12-AS1 LncRNA Homo sapiens Glioma Glioma tissues Interaction[P53] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay qPCR results in the study revealed that SAMD12-AS1 expression in tumor tissue specimens of glioma patients was remarkably higher than that in the adjacent ones, and the difference was statistically significant.In addition, compared to the NC group, knocking down SAMD12-AS1 markedly attenuated the proliferation rate, as well as the invasiveness and migration ability of glioma cells. Subsequently, in glioma tissues, it was verified that P53 expression was remarkably decreased and negatively correlated with SAMD12-AS1. Finally, cell recovery experiment also demonstrated that there may exist a mutual regulation between SAMD12-AS1 and P53, which then together affected the malignant progression of glioma. Compared with patients with low expression of SAMD12-AS1, patients with high expression of SAMD1-AS1 had a higher incidence of lymph node or distant metastasis. Yes In addition, compared to the NC group, knocking down SAMD12-AS1 markedly attenuated the proliferation rate, as well as the invasiveness and migration ability of glioma cells. 31646576 SBF2-AS1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues and cell lines Interaction(miR-494-3p/FGFR2 axis ) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Long non-coding RNA (lncRNA) SBF2-AS1 was highly expressed in DLBCL tissues and cell lines. Furthermore, SBF2-AS1 acted as a sponge of miR-494-3p and inhibited its expression. And miR-494-3p directly targeted FGFR2. Yes Silencing of SBF2-AS1 inhibited the viability and growth of OCI-LY-3 cells. 33519236 SBF2-AS1 LncRNA Homo sapiens Laryngeal Neoplasms LSCC tissues and cell lines Interaction(miR-302b-3p/TGFBR2 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//RNA-seq//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay We verified that SBF2-AS1 was significantly downregulated in LSCC tissues and cell lines using qRT-PCR analysis. Subsequent mechanistic studies revealed that SBF2-AS1 acted as a competing endogenous RNA that upregulated the expression of TGFBR2 by endogenous sponging for miR-302b-3p in LSCC cell lines. Its low expression was correlated to lymph node metastasis and an advanced clinical stage. More importantly, LSCC patients with low expression of SBF2-AS1 tended to have a poor prognosis. Yes Based on this, we performed gain-of-function and loss-of-function experiments in LSCC cell lines. The results confirmed that knocking down SBF2-AS1 can promote the metastasis of LSCC cells and enhance epithelial-mesenchymal transition phenotype, while the upregulation of SBF2-AS1 expression resulted in the opposite. Our in vivo model verified that SBF2-AS1 overexpression could inhibit LSCC cell metastasis. 34644425 RUSC1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[hsa-miR-7-5p/NOTCH3 axis] qRT-PCR//Luciferase Report Assay//RIP In this study, we found that RUSC1-AS1 was upregulated in HCC tissues and cells, and predicted unfavorable prognosis of HCC patients.In conclusion, lncRNA RUSC1-AS1 promoted the proliferation and reduced the apoptosis of HCC cells through activation of NOTCH signaling via hsa-miR-7-5p/NOTCH3 axis. Yes The function assays including colony formation, EdU, TUNEL assay revealed that RUSC1-AS1 facilitated HCC cell proliferation and inhibited HCC cell apoptosis. 32701359 SBF2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-338-3p/ADAM17 axis] Northern Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//ELISA//Colony Formation Assay//Transwell Assay In this study, we revealed that SBF2-AS1 was overexpressed in NSCLC tissues compared with that in normal tissues. Finally, we revealed that SBF2-AS1 contributed to the proliferation and metastatic phenotypes of NSCLC cell via regulating miR-338-3p/ADAM17 axis. Yes SBF2-AS1 silencing restrained the growth and aggressive phenotypes of NSCLC cell in vitro. Consistently, SBF2-AS1 knockdown hindered the growth of NSCLC cell in nude mice. 32976115 SCARB1 CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and RCC cell regulation[Mir- 510-5p/SDC3 Axis] qRT-PCR//Microarray Circ-SCARB1 was elevated in 30 pairs of RCC tissues and multiple RCC cell lines. Circ-SCARB1 promotes RCC progression via sequestering miR-510-5p and indirectly up-regulating SDC3 expression. Yes Knockdown of Circ-SCARB1 inhibited cell proliferation, migration, and invasion while inducing cell apoptosis. 32271695 SCAMP1-TV2 LncRNA Homo sapiens Breast Neoplasms regulation[SCAMP1-TV2/PUM2/INSM1 pathway] RNA Pull-Down//CCK8//RIP//Luciferase Report Assay//ChIP SCAMP1-TV2/PUM2/INSM1 pathway plays an important role in regulating the biological behavior of breast cancer cells. Yes Silenced SCAMP1-TV2 inhibited the proliferation, migration, and invasion of breast cancer cells, and promoted cell apoptosis. 32670859 SCAMP1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines Interaction[miR-429] RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay SCAMP1 was elevated in RCC cells and tumors.Then, miR-429 was identified as downstream effector for SCAMP1-mediated tumorigenesis under H2O2 treatment. Besides, miR-429 was downregulated in human clinical tumors. ZEB1 and JUN were both found to be involved in the role of miR-429 in RCC. More interestingly, autophagy obviously affected miR-429-modulated RCC tumorigenesis. Eventually, we also showed that SCAMP1 played an oncogenic role in vivo. Yes SCAMP1 depletion attenuated cell viability and promoted apoptosis under H2O2 treatment. 31550675 SCAMP1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues regulation[miR-137/CXCL12 Axis] qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay Finally, through TCGA database, we found that SCAMP1 (or CXCL12) was upregulated as well as miR-137 was downregulated in OC tissues, and high (or low) level of them was associated with poor prognosis. In summary, our study clarified the role of SCAMP1/miR-137/CXCL12 axis in OC, and this finding may provide a potential therapeutic target of OC. Finally, through TCGA database, we found that SCAMP1 (or CXCL12) was upregulated as well as miR-137 was downregulated in OC tissues, and high (or low) level of them was associated with poor prognosis. Yes In this study, we found that SCAMP1 was highly expressed in OC cells, which promoted OC cell invasion and angiogenesis. 32401536 SCAMP1 LncRNA Homo sapiens Glioma cell lines Regulation[miR-499a-5p/LMX1A/NLRC5 pathway] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Transwell Assay The present study demonstrated that LncRNA secretory carrier membrane protein 1 (SCAMP1) was up-regulated and functioned as an oncogene in glioma cells. In conclusion, our study clarifies that SCAMP1/miR-499a-5p/LMX1A/NLRC5 axis plays a critical role in modulating malignant progression of glioma cells, which provide a novel therapeutic strategy for glioma treatment. Yes Subsequently, inhibition of SCAMP1 significantly restrained the cell proliferation, migration and invasion, as well as promoted apoptosis by acting as a molecular sponge of miR-499a-5p. 31207033 SBF2-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[miR-545/EMS1 Axis] Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay LncRNA SBF2-AS1 expression was upregulated in GC tissues, especially in advanced clinical stage cases.These findings elucidated a crucial role of SBF2-AS1 as a miR-545 sponge in GC cells, suggesting that SBF2-AS1 might be a potential target for GC. Moreover, increased SBF2-AS1 indicated a poor survival rate. Yes Functionally, the downregulation of SBF2-AS1 by siRNA in GC cells suppressed the proliferation, migration, and invasion. 32626753 SBF2-AS1 LncRNA Homo sapiens Stomach Neoplasms GC cell lines, GC tissues Regulation(Wnt/LRP5 Signaling Pathway) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//cell invasion assay SBF2-AS1 was aberrantly expressed in GC cell lines (p<0.05) and GC tissues (p<0.05). Additionally, online database analysis uncovered a positive correlation between SBF2-AS1 and the Wnt/LRP5 signaling pathway (p<0.05). SBF2-AS1 knockdown blocked the Wnt/LRP5 signaling pathway, whereas the effects of SBF2-AS1 knockdown on the malignant genotype of MKN74 as well as NCI-N87 cells were partially restored by triggering the Wnt/ LRP5 signaling pathway. Yes Cell invasive and proliferative capabilities were inhibited via SBF2-AS1 knockdown, resulting in apoptosis of NCI-N87 and MKN74 cells. 36549764 SBF2-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells interaction[miR-143,RRS1] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//FISH//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay SBF2-AS1 and RRS1 were amplified, while miR-143 was reduced in BC tissues and cells.We have discovered in this study that down-regulated SBF2-AS1 could inhibit tumorigenesis and progression of BC by up-regulation miR-143 and repressing RRS1, which provides basic therapeutic considerations for a novel target against BC. Yes Reduced SBF2-AS1 and elevated miR-143 could repress the proliferation, invasion and migration via restraining RRS1 expression. 31952549 SBF2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tumors and cells regulation[miR-494 ,PFN2 ] RNA Pull-Down//Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay In the present research, we found that the expression of SBF2-AS1 and PFN2 was up-regulated, while miR-494 was down-regulated in ESCC tumors and cells using quantitative real-time polymerase chain reaction (qRT-PCR).In conclusion, SBF2-AS1 contributed to cell proliferation, migration, invasion and EMT in ESCC by enhancing PFN2 expression via sponging miR-494, providing promising biomarkers for ESCC diagnosis and treatment. Yes 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide (MTT) assay and transwell assay demonstrated that silencing of SBF2-AS1 suppressed proliferation, migration and invasion. 32229486 SBF2-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cells Interaction(miR-338-3p/ ETS1) In Vivo Experiment//Western Blot//ISH//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//IHC//Bioinformatics Analysis//Transwell Assay SBF2-AS1 was found to be highly expressed in ccRCC tissues and cells. SBF2-AS1 specifically bound to miR-338-3p and inhibited its expression. Moreover, ETS1 was targeted by miR-338-3p. The knockdown of SBF2-AS1 or ETS1 or overexpression of miR-338-3p resulted in reduced cell proliferation, migration and invasion but elevated cell apoptosis and autophagy. In vivo experiments verified the tumor-suppressive role of silencing SBF2-AS1 in tumor growth of nude mice xenografted with ccRCC cells. Yes Ectopic expression and knockdown of SBF2-AS1 and miR-338-3p were performed in ccRCC 768-O cells to explore their effects on cell proliferation, migration, invasion, apoptosis and autophagy by EdU assay, scratch test, Transwell assay, calcein-AM/PI, and GFP-LC3 immunofluorescence assays, respectively. 32719443 SBF2-AS1 LncRNA Homo sapiens Colorectal Neoplasms Cell lines Interaction[inhibiting miR-619-5p] qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Transwell Assay Accordingly, SBF2-AS1 possesses higher expression in CRC cell lines than in normal cell line. In terms of mechanism, SBF2-AS1 upregulation restrained the activity of miR-619-5p and led to overexpression of HDAC3. Importantly, downregulation of miR-619-5p or HDAC3 overexpression reversed SBF2-AS1-silencing-caused suppression on proliferation and metastasis. Yes Functionally, SBF2-AS1 knockdown suppressed the proliferation, migration, and invasion of CRC cells. 30912164 SBF2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation[EMT pathway] qRT-PCR//MTT//Western Blot//Transwell Assay We found that SBF2-AS1 expression levels were significantly up-regulated in HCC tissues and cell lines compared with the corresponding noncancerous liver tissues and normal hepatic cell line. Mechanistically, we found that SBF2-AS1 could promote the activation of EMT pathway, which was demonstrated by measuring the expression levels of EMT-related markers. In addition, high SBF2-AS1 expression levels were correlated with vein invasion (p = 0.008) and TNM stage (p = 0.013). Furthermore, Kaplan-Meier survival analysis indicated that high expressions of SBF2-AS1 were correlated with shorter overall survival of HCC patients. Yes Further functional analysis demonstrated that knockdown of SBF2-AS1 significantly inhibited HCC cells proliferation, migration and invasion. 30338801 SBF2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miR-361-5p/TGF-β1 signaling pathway) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay lncRNA SBF2-AS1 concentration in HCC cells exceeded that in a normal hepatocyte cell line. The downregulation of lncRNA SBF2-AS1 upregulated miR-361-5p levels in HCC cells. And, miR-361-5p negatively regulate TGF-β1 expression in HCC cells. Yes  The suppression of miR-361-5p attenuated the influence of lncRNA SBF2-AS1 downregulation on the viability, proliferation, and migration capability of HCC cells. Further, the downregulation of lncRNA SBF2-AS1 inhibited neoplasm growth in an XMM of HCC.  34341185 SBF2-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute cell lines Interaction[binding with miR-188-5p] CCK8//qRT-PCR//Flow Cytometry QRT-PCR results showed that SBF2-AS1 expression was upregulated in AML cells. Mechanistically, miR-188-5p was identified as a direct target of SBF2-AS1. SBF2-AS1 upregulated the expression level of ZFP91 by sponging miR-188-5p. And the effects of SBF2-AS1 suppression on AML cells progression could be abolished by miR-188-5p inhibitors. Moreover, we found that SBF2-AS1 inhibition reduced tumor growth in vivo. Taken together, our findings elucidated that SBF2-AS1 could act as a miRNA sponge in AML progression, and provided a potential therapeutic strategy for AML treatment. Yes CCK-8 assay revealed that SBF2-AS1 inhibition decreased AML cells proliferation ability in vitro.Moreover, we found that SBF2-AS1 inhibition reduced tumor growth in vivo. 31062614 SBF2-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Regulation[miR-361-5p/FOXM1 axis] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay In the present study, our data showed that SBF2-AS1 expression was significantly increased in CC. Mechanistically, we showed that SBF2-AS1 Expression[Expression[up-expression]-expression]regulation restrained the activity of miR-361-5p and led to overexpression of FOXM1 in CC cells. Furthermore, we found that miR-361-5p inhibitors could rescue the effects of SBF2-AS1 inhibition on CC cells proliferation. High SBF2-AS1 expression was associated with advanced FIGO stage and lymph node metastasis of CC patients. Yes Function assays showed that SBF2-AS1 inhibition significantly reduced CC cells proliferation both in vitro and in vivo. 30856345 SBF2-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues regulation[miR-431-5p/CDK14 axis] qRT-PCR First, differentially expressed SBF2-AS1 between PTC and normal adjacent thyroid tissues was determined, and result indicated a higher SBF2-AS1 expression in PTC tissues than adjacent normal tissues. Moreover, SBF2-AS1 could bind with miR-431-5p and showed negative correlation with miR-431-5p in PTC patients. Furthermore, miR-431-5p bind with cyclin-dependent kinase (CDK) 14 and showed negative correlation with CDK14 in PTC patients. Moreover, highly SBF2-AS1 expression predicted a poor prognosis in PTC patients. Yes Second, SBF2-AS1 overexpression promoted cell viability and cycle of PTC, while inhibited cell apoptosis. 32602632 SBF2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[miR-362-3p/GRB2 Axis] Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay//ChIP We found that SBF2-AS1 was upregulated in both NSCLC tissues and cell lines.These results demonstrate that E2F1-induced overexpression of SBF2-AS1 promotes the expression of GRB2 by targeting miR-362-3p to facilitate the metastasis of NSCLC. Patients with high levels of SBF2-AS1 have larger tumors, higher malignancy, and poor prognosis. Yes Knockdown of SBF2-AS1 significantly inhibited tumor growth in vivo and cell proliferation, migration, and invasion in vitro. 32364763 RUSC1-AS-N LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[Wnt/β‑catenin signaling] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay A total of 100 patients with breast cancer were recruited for this study and it was revealed that RUSC1‑AS‑N was upregulated in tumor tissues compared with in adjacent non‑cancerous counterparts. In addition, using several breast cancer cell lines, it was demonstrated that the mRNA levels of RUSC1‑AS‑N were highest in the notably metastatic cell lines MDA‑MB‑231 and MDA‑MB‑468. The present study demonstrated that lncRNA RUSC1‑AS‑N promoted cell viability and metastasis via Wnt/β‑catenin signaling in human breast cancer, which may indicate novel targets for the treatment of breast cancer in clinic. Yes Knockdown of RUSC1‑AS‑N in breast cancer cells inhibited cell proliferation in the colony formation and cell proliferation assays. Furthermore, depletion of RUSC1‑AS‑N suppressed cell metastasis, as revealed by wound‑healing and western blot assays. 30569097 RUSC1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and HCC cell lines Interaction(miR-340-5p/CREB1 axis) CCK8//qRT-PCR//Wound Healing Assay When compared with normal groups, RUSC1-AS1 expression in HCC tissues and HCC cell lines was higher. Further studies demonstrated that the expression of RUSC1-AS1 negatively correlated with miR-340-5p expression in HCC cells. In addition, miR-340-5p was identified as a direct target of RUSC1-AS1 and tightly associated with the prevention of tumor progression. Moreover, miR-340-5p bound directly to CREB1. CREB1 overexpression reversed the impact of miR-340-5p on HCC cells. Together, lncRNA RUSC1-AS1 plays a regulatory role in the PI3K/AKT signaling pathway in HCC cells. Yes We also found that knockdown of RUSC1-AS1 inhibited HCC cell progression, including proliferation, migration, and invasion, and suppressed tumorigenesis in vivo. 33841637 RPL34-DT LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-3656 ) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//BrdU In this study, increased expression levels of miR-3656 and decreased expression levels of RPL34-AS1 were observed in CRC tissues. MiR-3656 directly interacted with RPL34-AS1, but not the RPL34-AS1 mutant with disrupted binding sites. RPL34-AS1 and miR-3565 did not affect the expression of each other. RPL34-AS1 positively regulated the expression of ACAP2 at both mRNA and protein levels. Yes RPL34-AS1 suppressed the role of miR-3565 in enhancing cell proliferation, while RPL34-AS1 mutant did not affect cell behaviors and the role of miR-3565 in cell proliferation. 35773374 RPPH1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell lines regulation[miR-326/WNT2B axis] CCK8//qRT-PCR//Colony Formation Assay RPPH1 was significantly upregulated in NSCLC cell lines, compared with a normal lung epithelial cell line. In conclusion, RPPH1 promoted NSCLC progression and lung cancer cell resistance to CDDP through miR-326 and WNT2B. Moreover, high RPPH1 expression was associated with poor overall survival and disease progression. Yes Compared with the negative control, RPPH1 silencing significantly reduced the number of invading cells, increased E-cadherin expression and reduced vimentin protein expression. 32831924 circFOXM1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[ circFOXM1/miR-614/FAM83D ] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP We found that circFOXM1 was significantly upregulated in NSCLC tissues, and its upregulation was positively correlated with advanced clinical stage and poor prognosis of NSCLC patients. circFOXM1/miR-614/FAM83D regulatory network may serve as a potential therapeutic target for NSCLC patients. We found that circFOXM1 was significantly upregulated in NSCLC tissues, and its upregulation was positively correlated with advanced clinical stage and poor prognosis of NSCLC patients. Yes Gain or loss-of-function assay showed that circFOXM1 promoted cell proliferation and cell cycle progression. 32228656 hsa_circ_0008003 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-488/ZNF281 axis] qRT-PCR//Microarray Then, it was unveiled that the expression of circ-0008003 examined via qRT-PCR was elevated in tumour tissues relative to the non-tumour tissues, which was associated with TNM stage and lymphatic metastasis in NSCLC. It was validated in this research that circ-0008003 triggered tumour formation in NSCLC, which was adjusted via miR-488/ZNF281 axis, casting a novel light on the resultful target for treating NSCLC and predicting the prognosis. Then, it was unveiled that the expression of circ-0008003 examined via qRT-PCR was elevated in tumour tissues relative to the non-tumour tissues, which was associated with TNM stage and lymphatic metastasis in NSCLC. Additionally, the prognosis of NSCLC patients with high circ-0008003 level was poor. Yes Besides, circ-0008003 silencing dampened the invasion and proliferation of NSCLC cells. 33320427 hsa_circ_0058357 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and NSCLC cells Interaction(hsa‑miR‑24‑3p/AVL9 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay The results demonstrated that hsa_circ_0058357 was highly expressed in human NSCLC tissues and NSCLC cells compared with para?cancerous tissues and human bronchial epithelial (HBE) cells, respectively. As a competing endogenous RNA, hsa_circ_0058357 knockdown contributed to the increase of miR‑24‑3p expression in NSCLC cells. Mechanistically, as a signaling molecule in late secretory pathway, AVL9 was also expressed at a high level in NSCLC tissues and cells, which could be directly suppressed by miR‑24‑3p. In the tumor tissues, along with growth inhibition, hsa_circ_0058357 knockdown also mediated the elevation of miR‑24‑3p and the reduction of AVL9. Yes Knockdown of hsa_circ_0058357 significantly suppressed cell viability, migration and tumor growth, while it promoted apoptosis in NSCLC cells. Of note, overexpression of miR‑24‑3p markedly abolished the exogenous hsa_circ_0058357‑induced excessive proliferation, migration and apoptosis resistance of NSCLC cells. 33880595 hsa_circ_0000735 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction[miR-1179/1182] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0000735 was elevated in both NSCLC tissues and cells. Moreover, we proved circ_0000735 could bound to miR-1179/1182 to exert its biological functions in NSCLC cells. This upregulation of circ_0000735 is associated with more advanced TNM stages and lymph node invasion. Yes Gain and loss of function experiments documented that circ_0000735 significantly facilitated cell proliferation, migratory and invasive abilities and inhibit cell apoptosis. 30737027 hsa_circ_0043278 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction[regulating miR-520f] RNA Pull-Down//Wound Healing Assay//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression in vitro and in vivo. In addition, we revealed that circ_0043278 sponged miR-520f, which was demonstrated to target ROCK1, CDKN1B, and AKT3 in NSCLC cells. In conclusion, circ_0043278 promoted NSCLC cell proliferation, invasion, and migration by increasing ROCK1, CDKN1B, and AKT3 expressions through direct inhibition of miR-520f. Yes In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression in vitro and in vivo. Then, we revealed the expression of miR-520f, a downstream factor of circ_0043278, was significantly down-regulated in NSCLC and acted as a tumor inhibitor. 30873868 RPS10P7 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cells and tissues Expression[highly expressed] IHC//Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay Bioinformatics analysis demonstrated that lnc-MCEI was involved in the tumorigenesis of ESCC and lnc-MCEI levels were significantly increased in ESCC cells and tissues. Yes Additionally, lnc-MCEI knockdown retarded cell proliferation, colony formation of ESCC cells, but induced cell apoptosis. 33061807 RPPH1 LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[repressing P21] Western Blot//Wound Healing Assay//qRT-PCR//EdU Staining//Transwell Assay It was shown in qRT-PCR assay results that the expression of RPPH1 was upregulated in 60 cases of GC tissues.Highly expressed RPPH1 promotes the proliferation and metastasis of GC cells by regulating p21 expression. Statistical analysis revealed that RPPH1 expression was positively correlated with the TNM stage, lymph node metastasis, and infiltration depth in GC patients. Besides, highly expressed lncRNA RPPH1 suggested poor prognosis of GC patients. Yes After interfering in RPPH1 expression, both colony formation assay and EdU staining indicated that the proliferative capacity of GC cells was repressed. 33215423 RPPH1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[TUBB3] ISH//RNA Pull-Down//IHC//RNA-seq In this study, we report that lncRNA RPPH1 was significantly upregulated in CRC tissues.Mechanistically, RPPH1 induced epithelial-mesenchymal transition (EMT) of CRC cells via interacting with β-III tubulin (TUBB3) to prevent its ubiquitination. In this study, we report that lncRNA RPPH1 was significantly upregulated in CRC tissues, and the RPPH1 overexpression was associated with advanced TNM stages and poor prognosis. Yes RPPH1 was found to promote CRC metastasis in vitro and in vivo. 31685807 circFBXW8 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues, cells and the exosomes Interaction(miR-370-3p/TRIM44) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay CircFBXW8 and TRIM44 expression were upregulated, while miR-370-3p was downregulated in NSCLC tissues, cells and the exosomes from NSCLC cells compared with respective controls. CircFBXW8 acted as a sponge of miR-370-3p and regulated NSCLC cell malignancy by binding to miR-370-3p. Additionally, miR-370-3p repressed NSCLC cell processes by regulating TRIM44. Yes CircFBXW8 depletion repressed NSCLC cell proliferation, migration and invasion, but promoted cell apoptosis. CircFBXW8 knockdown inhibited tumor formation in vivo. Further, circFBXW8 secretion was mediated by exosomes. 34988777 RPPH1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML tissues and cell lines Regulation[RPPH1/miR-330-5p axis] Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//cell invasion assay RPPH1 was expressed in the AML tissues and cell lines and its high expression predicted worse overall survival in AML patients. Our work highlights the contributions of RPPH1 in promoting AML progression through targeting miR-330-5p, and suggests that the RPPH1/miR-330-5p axis is a potential target for AML treatments. RPPH1 was expressed in the AML tissues and cell lines and its high expression predicted worse overall survival in AML patients. Yes Knockdown of RPPH1 suppressed the proliferation, invasion and migration ability of human AML cells, which was partially reversed by additional administration with miR-330-5p inhibitor. RPPH1 knockdown significantly inhibited the growth of xenografted THP-1 tumor in nude mice. 31645843 Rpph1 LncRNA Mus musculus Alzheimer Disease cortical tissues Regulation[miR-122/Wnt1 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay Both lncRNA Rpph1 and miR-122 were up-regulated in AD mouse. Both lncRNA Rpph1 and miR-122 were up-regulated in AD mouse and Rpph1 activated Wnt/β-catenin signaling to ameliorate amyloid-β induced neuronal apoptosis in SK-N-SH cells via direct targeting miR-122. Yes Either over-expression of Rpph1 or inhibition of miR-122 restored the cell viability or decreased cell apoptosis rate in Aβ induced SK-N-SH cells. 31718352 Rpph1 LncRNA Mus musculus Diabetic Nephropathies renal tissues Regulation[Gal-3/Mek/Erk signaling pathway] RNA Pull-Down//Western Blot//qRT-PCR//RIP//FISH//RNA-seq//ELISA//EdU Staining In this study, we identified differentially expressed lncRNAs in DN using RNA-sequencing. Among these lncRNAs, we identified seven DN-related lncRNAs in vivo and in vitro using quantitative real-time PCR. One lncRNA in particular, Rpph1 (ribonuclease P RNA component H1), exhibited significantly increased expression. The results revealed that Rpph1 directly interacts with the DN-related factor galectin-3 (Gal-3). Further, over-expression of Rpph1 promoted inflammation and cell proliferation through the Gal-3/Mek/Erk signaling pathway in MCs under low glucose conditions, while knockdown of Rpph1 inhibited inflammation and cell proliferation through the Gal-3/Mek/Erk pathway in MCs under high glucose conditions. These results provide new insight into the association between Rpph1 and the Gal-3/Mek/Erk signaling pathway during DN progression. Yes Further, over-expression or knockdown of Rpph1 was found to regulate cell proliferation and the expression of inflammatory cytokines in mesangial cells (MCs). 31285427 RPLP0P2 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression(highly expressed) CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Invasion Assay The results demonstrated that the expression levels of RPLP0P2 were higher in CRC tissue compared with those in normal tissue, and RPLP0P2 was associated with prognosis. . The results demonstrated that the expression levels of RPLP0P2 were higher in CRC tissue compared with those in normal tissue, and RPLP0P2 was associated with prognosis. Yes RPLP0P2 knockdown significantly decreased cell colony formation, migration and invasion, and arrested CRC cells in the S phase to G2/M phase transition. Furthermore, apoptosis was significantly increased in CRC cells infected with the RPLP0P2 shRNA lentivirus compared with in the control group. 33649783 F-circEA-2a CircRNA Homo sapiens gastric adenocarcinoma GA tissues Interaction(miR-3940-5p) BrdU//qRT-PCR//Transfection//RNA Pull-Down We found that F-circEA-2a and premature miR-3940-5p were overexpressed in GA, while mature miR-3940-5p was under-expressed in GA.F-circEA-2a suppressed miR-3940-5p maturation in GA cells. MiR-3940-5p directly bound to F-circEA-2a wild type (-wt), but not mutant (-mut). Yes F-circEA-2a promoted GA cell proliferation and inhibited the role of miR-3940-5p in reducing cell proliferation. Therefore, F-circEA-2a might suppress mature miR-3940-5p formation by sponging premature miR-3940-5p to promote cell proliferation in GA. 35235752 circABCB10 CircRNA Homo sapiens laryngeal carcinoma HaCat cells Expression(lower expressed) Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry The results of RT-qPCR detection indicated that the expression of circ-ABCB10 in all three laryngeal carcinoma cells was downregulated by 3.2 times compared with that of HaCat cells. There is low expression of circ-ABCB10 in most laryngeal carcinoma tissues, the diagnostic cutoff value of circ-ABCB10 is 0.0008, the area under the curve is 0.718, the sensitivity is 0.981, and the specificity is 0.556. The expression of circ-ABCB10 in laryngeal carcinoma was significantly higher compared to that in paracancerous tissues. Silencing circ-ABCB10 could significantly inhibit the growth and proliferation of laryngeal adenocarcinoma cells, while overexpression of circ-ABCB10 could significantly promote the growth of laryngeal adenocarcinoma cells, probably by inhibiting KLF6 to enhance the proliferation of laryngeal carcinoma and inhibit apoptosis. Yes The expression level of KLF6 in laryngeal carcinoma is on the rise, which is significantly higher compared to healthy tissues (P < 0.05); 48 hours after transfection, RT-qPCR analysis confirmed the transfection efficiency, and upregulation of circ-ABCB10 could significantly promote cell proliferation. Compared with the control group, silencing circ-MTCL1 could inhibit cell proliferation, overexpression of circ-ABCB10 promoted cell migration, and downregulation of circ-ABCB10 significantly inhibited cell movement (P < 0.001). Upregulation of circ-ABCB10 significantly enhanced the invasiveness and motility of laryngeal cancer cells, while downregulation of circ-ABCB10 was the opposite. 35756421 hsa_circ_0008450 CircRNA Homo sapiens Liver Neoplasms HCC tissues ,cells regulation[miR-431/AKAP1 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay Circ_0008450 was upregulated in HCC tissues and hypoxia-disposed HCC cells. In conclusion, circ_0008450 repression mitigated the progression of HCC under hypoxia by downregulating AKAP1 via miR-431, providing a potential target for HCC treatment. Yes Depletion of circ_0008450 suppressed tumor growth in vivo and reversed the repression of apoptosis and the acceleration of viability and glycolysis of HCC cells induced by hypoxia treatment in vitro. 33193848 RPL34-DT LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR-575/ACAA2 axis) Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay RPL34-AS1 was significantly down-regulated in ESCC tissues and cells, which was negatively correlated with overall survival in ESCC patients. Functionally, upregulation of RPL34-AS1 dramatically suppressed ESCC cell proliferation, colony formation, invasion and migration in vitro, whereas knockdown of RPL34-AS1 elicited the opposite function. Consistently, overexpression of RPL34-AS1 inhibited tumor growth in vivo. Mechanistically, RPL34-AS1 acted as a competing endogenous RNA (ceRNA) of miR-575 to relieve the repressive effect of miR-575 on its target ACAA2, then suppressed the tumorigenesis of ESCC. RPL34-AS1 was significantly down-regulated in ESCC tissues and cells, which was negatively correlated with overall survival in ESCC patients. Yes Functionally, upregulation of RPL34-AS1 dramatically suppressed ESCC cell proliferation, colony formation, invasion and migration in vitro, whereas knockdown of RPL34-AS1 elicited the opposite function. Consistently, overexpression of RPL34-AS1 inhibited tumor growth in vivo. 36162992 hsa_circ_0072309 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC samples Interaction(miR-607/FTO axis ) In Vivo Experiment//RNA Pull-Down//cell invasion assay//qRT-PCR//Luciferase Report Assay//migration assay//Cell Proliferation Assay//IHC Based on a microarray assay, we found that hsa_circ_0072309 was significantly upregulated in NSCLC compared with matched normal samples. Through the above work, we found that hsa_circ_0072309 interacted with miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC. Yes Moreover, functional experiments demonstrated that hsa_circ_0072309 promotes the proliferation, migration, and invasion of NSCLC cells. 33879631 RUSC1-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma cell line U2OS and HOS, human samples Interaction(miR-340-5p and PI3K/AKT pathway) qRT-PCR//RIP The results showed that the expression of RUSC1-AS1 was significantly upregulated in osteosarcoma cell line U2OS and HOS compared to that in human osteoblast cell line hFOB1.19. Similar results were found in human samples. Mechanically, we showed that RUSC1-AS1 directly binds to and inhibits miR-340-5p and activates the PI3K/AKT signaling pathway. Yes Silencing RUSC1-AS1 by siRNA significantly inhibited U2OS and HOS cell proliferation and invasion, measured by CCK-8 and transwell assay. Besides, knockdown of RUSC1-AS1 increased cell apoptosis in osteosarcoma cell lines.In addition, RUSC1-AS1 promoted the epithelial-mesenchymal transition (EMT) process of osteosarcoma cells. In vivo experiments confirmed that RUSC1-AS1 knockdown had an inhibitory effect on osteosarcoma tumor growth. 34048366 RUBCNL LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[NF-κB pathway ] Western Blot//Wound Healing Assay//qRT-PCR//FISH//MTT//Luciferase Report Assay//ELISA//Colony Formation Assay//Transwell Assay RT-qPCR analysis revealed that PACER was highly expressed in CRC tissues and cells, and a high PACER-expression level was associated with poor prognosis.PACER modulates COX-2 expression through the nuclear factor kappa B (NF-κB) pathway in CRC. RT-qPCR analysis revealed that PACER was highly expressed in CRC tissues and cells, and a high PACER-expression level was associated with poor prognosis. Yes MTT assay, wound-healing assay, colony-formation assay, and transwell assay revealed that PACER enhanced CRC-cell proliferation, invasion, and metastasis in vitro. Mouse xenograft models of CRC revealed that PACER promoted colorectal tumorigenesis in vivo. 34316376 RUNX1-IT1 LncRNA Homo sapiens Lung Neoplasms cancerous lung cells and tissues Expression(lower expressed) CCK8//qRT-PCR//Western Blot//Transwell Assay Low expression levels of lncRNA RUNX1-IT1 were detected in the cancerous lung cells and tissues. The findings of the Western blot assessment showed that the overexpression or knockdown of lncRNA RUNX1-IT1 significantly affected the expression of cluster of differentiation 44, cluster of differentiation 133, sex-determining region Y-box 2, octamer-binding transcription factor 4, and Nanog, and regulated the sphere-forming ability of cells. Yes The overexpression of lncRNA RUNX1-IT1 significantly restricted the ability of cells to proliferate, produce clones, form spheres, and invade lung cancer cells, while the knockdown of lncRNA RUNX1-IT1 had the opposite effect. Additionally, the overexpression or knockdown of lncRNA RUNX1-IT1 regulated the invasion ability of cells by affecting expressions of E-cadherin, N-cadherin, and Vimentin. 35116340 RUNX1-IT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,CRC cell lines (HCT116, HT29, and RKO) Expression[lower expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Significant down regulation of lncRNA RUNX1-IT1 was measured in CRC tissues and three CRC cell lines (HCT116, HT29, and RKO) compared with paired nontumorous adjacent tissues (P < 0.01) or the normal colonic epithelial cell line FHC (P < 0.05), respectively. The protein levels of PCNA, Ki67, and MMP9 were upregulated by overexpressing lncRNA RUNX1-IT1 and down regulated in si-RUNX1-IT1 cells. Besides, lncRNA RUNX1-IT1 could also promote the apoptosis of CRC cells. In conclusion, lncRNA RUNX1-IT1 is downregulated in CRC and plays a tumour-suppressive role due to the regulatory of cell proliferation, migration, and apoptosis. SIGNIFICANCE OF THE STUDY: We demonstrated that lncRNA RUNX1-IT1 was down regulated both in CRC tissues and cell lines. Besides, lncRNA RUNX1-IT1 could serve as a potential diagnostic biomarker and play a tumour-suppressive role owing to its good diagnostic efficacy and inhibition of CRC cell proliferation and migration Yes Moreover, the proliferative and migration potential of CRC cells were inhibited by overexpressing lncRNA RUNX1-IT1, which could be obviously improved by knocking down lncRNA RUNX1-IT1. 30499136 RUNX1-IT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC Tissues,cell lines (Huh7, Hep3B, and HCCLM3) Interaction[MAPK pathways] CCK8//qRT-PCR//Western Blot "he expression level of lncRNA RUNX1-IT1 significantly decreased in HCC tissues. The protein changes of P-P38, P-ERK, and P-JNK in cells overexpressing lncRNA RUNX1-IT1 were significantly lower than those of the vector groExpression[Expression[up-expression]-expression] (p<0.05). However, no significant changes were found in the protein expressions of P38, ERK, and JNK (Figures 4A, 4B). In addition, the pro_x0002_tein changes of P-P38, P-ERK, and P-JNK in the cells with Expression[down-expression]-expression of lncRNA RUNX1- IT1 were remarkably higher than those of the vector groExpression[Expression[up-expression]-expression] (p<0.05). Similarly, no significant changes were found in the protein expressions of P38, ERK, and JNK (Figures 4C, 4D). " Yes The overexpression of lncRNA RUNX1-IT1 remarkably inhibited the proliferation and induced the apoptosis of HCC cells. On the contrary, the knockExpression[down-expression] of lncRNA RUNX1-IT1 remarkably enhanced the ability of proliferation and repressed the apoptosis of the HCC cells. 31646558 RUNX1-IT1 LncRNA Homo sapiens Glioblastoma GBM tissues Interaction(miR-195/cyclin D1) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay RUNX1-IT1 was upregulated in GBM. RUNX1-IT1 and miR-195 interacted with each other, but failed to regulate the expression of each other. Overexpression of RUNX1-IT1 resulted in the upregulation of cyclin D1, and also reduced the effects of miR-195 overexpression on cyclin D1 expression. RUNX1-IT1 and cyclin overexpression increased cell proliferation, while miR-195 overexpression decreased cell proliferation. In addition, RUNX1-IT1 overexpression reduced the effects of miR-195 overexpression on cell proliferation. Yes RUNX1-IT1 and cyclin overexpression increased cell proliferation, while miR-195 overexpression decreased cell proliferation. In addition, RUNX1-IT1 overexpression reduced the effects of miR-195 overexpression on cell proliferation. 33507136 RUNX1-IT1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues regulation[RUNX1 ] qRT-PCR//RNA-seq In this study, we identified a novel PC-associated lncRNA, RUNX1-IT1, that was significantly upregulated in PC patient samples from multiple centers and associated with poor prognosis. Overall, RUNX1-IT1 is a crucial oncogenic lncRNA that activates C-FOS expression by regulating and recruiting RUNX1 and is a potential prognostic biomarker and therapeutic target for PC. In this study, we identified a novel PC-associated lncRNA, RUNX1-IT1, that was significantly upregulated in PC patient samples from multiple centers and associated with poor prognosis. Yes In vitro and in vivo, alterations in RUNX1-IT1 expression markedly affected PC proliferation, migration and invasion. 32487998 RUNX1-IT1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues regulation[miR-21] CCK8//qRT-PCR//RNA Pull-Down//Luciferase Report Assay We found that RUNX1-IT1 was downregulated in EC and inversely correlated with mature miR-21 but not miR-21 precursor. RUNX1-IT1 is downregulated in EC and inhibits cancer cell proliferation by suppressing the maturation of miR-21. Yes Overexpression of RUNX1-IT1 suppressed the role of miR-21 in increasing cell proliferation. 33408517 RUNDC3A-AS1 LncRNA Homo sapiens Thyroid Neoplasms THCA cells Interaction(miR-151b/SNRPB Axis) Western Blot//Bioinformatics Analysis//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining RUNDC3A-AS1 exhibited high expression in THCA cells. Importantly, RUNDC3A-AS1 targeted miR-151b to regulate the SNRPB expression. In rescue assays, SNRPB overexpression partially reversed the suppressive effect of RUNDC3A-AS1 knockdown on cell proliferation and the promotive effect of RUNDC3A-AS1 knockdown on cell apoptosis. The RUNDC3A-AS1/miR-151b/SNRPB axis regulated THCA cell proliferation and apoptosis, which provides novel insight into THCA investigation at the molecular level. Yes RUNDC3A-AS1 knockdown suppressed cell proliferation but induced cell apoptosis. 35242185 RUNDC3A-AS1 LncRNA Homo sapiens Thyroid Cancer Lung Metastasis thyroid cancer tissues and cell lines Interaction(miR-182-5p/ADAM9) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The results indicated that RUNDC3A-AS1 was highly expressed in the thyroid cancer tissues and cell lines.Mechanistically, RUNDC3A-AS1 served as an inhibitor of miR-182-5p in tumor tissues and cell lines. RUNDC3A-AS1 inhibited the expression of miR-182-5p to increase the expression level of ADAM9, thus further aggravating the malignancy of thyroid cancer. Yes Functionally, knockdown of RUNDC3A-AS1 could repress the migration and invasion of thyroid cancer cells in vitro, and inhibit thyroid cancer metastasis to lung in vivo. 34046406 RUBCNL LncRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[highly expressed] CCK8//qRT-PCR//Transwell Assay PACER was upregulated in serum of COPD patients, which was a potential biomarker for diagnosing COPD. Yes Overexpression of PACER in primary rat alveolar epithelial cells enhanced proliferative and migratory abilities. 33378047 circHMGCS1 CircRNA Homo sapiens Hepatoblastoma HB tissues Regulation[IGF Signaling Pathway ] ISH//qRT-PCR//circRNA-seq In this report, we analyzed the expression prolife of circRNAs in HB tissues and identified circHMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1; hsa_circ_0072391) as a remarkably upregulated circRNA.CircHMGCS1 regulates IGF2 and IGF1R expression via sponging miR-503-5p, and affects the downstream PI3K-Akt signaling pathway to regulate HB cell proliferation and glutaminolysis. HB patients with high circHMGCS1 expression have shorted overall survival. Yes Knockdown of circHMGCS1 inhibits HB cells proliferation and induces apoptosis. 30809316 RUBCNL LncRNA Homo sapiens Mycoplasma Pneumoniae-Induced Inflammatory A549 cells Interaction(NF-κB) Other First, we observed that PACER was upregulated in MP infected A549 cells. By performing luciferase reporter assay, we found PACER knockdown inhibited NF-κB activation induced by MP. Furthermore, RNA immunoprecipitation showed that PACER could physically bind to NF-κB p50 in MP-treated A549 cells. Yes Knockdown of PACER suppressed the production of inflammatory cytokines as well as the expression of COX-2 in A549 cells after MP infection. 35181614 RSU1P2 LncRNA Homo sapiens Liver Neoplasms liver cancer tissues and cells Interaction(microRNA let-7a/Tex10) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//cell invasion assay//Colony Formation Assay//Transwell Assay In this study, the expression of LncRNA RSU1P2 was significantly elevated in liver cancer tissues and cells. In addition, LncRNA RSU1P2 can interact with microRNA let-7a (let-7a), and repress let-7a expression. Testis-Expressed Protein 10 (Tex10) was identified to be a target of let-7a, and let-7a repressed Tex10 expression. Yes Besides, knockdown of RSU1P2 repressed cell viability, invasion, epithelial-mesenchymal transition (EMT) of liver cancer cells and the expressions of cancer stem cell-related genes, whereas facilitated the apoptosis of liver cancer cells. Finally, RSU1P2 knockdown suppressed tumor volume, tumor weight, and EMT in a xenograft model. 35156514 RPSAP52 LncRNA Homo sapiens Stomach Neoplasms GC cells Interaction( miR-665/STAT3) RNA Pull-Down//Northern Blot//Western Blot//Flow Cytometry//qRT-PCR//CCK8 LncRNA RPSAP52 is significantly elevated in GC cells. MiR-665 was verified as the target of lncRNA RPSAP52. A ceRNA-sponge mechanism of lncRNA RPSAP52 on miR-665 was identified. Meanwhile, miR-665 functions as STAT3 sponge. MiR-665 overexpression and STAT3 depletion served the same functions as lncRNA RPSAP52 depletion in GC cells. LncRNA RPSAP52 exerted anti-cancer effects via modulating miR-665/STAT3 in GC. Yes Deletion of lncRNA RPSAP52 restrained cell proliferation and induced G0-G1 phase arrest, while expediting apoptosis in GC cells. Tumor growth in vivo was suppressed following lncRNA RPSAP52 depletion. 35322746 RPSAP52 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck TSCC samples Interaction( miR-423-5p/MYBL2) Transfection//qPCR//Luciferase Report Assay//Cell Proliferation Assay//ELISA We indicated that RPSAP52 was higher in TSCC samples compared with that in control samples. We found that the overexpression of RPSAP52 suppressed miR-423-5p expression in SCC-4 cell.Pearson's correlation indicated that miR-423-5p was negatively associated with that of RPSAP52 in TSCC tissues. Furthermore, MYBL2 was one direct gene of miR-423-5p and elevated expression of miR-423-5p suppressed MYBL2 expression and ectopic expression of RPSAP52 increased MYBL2 expression in SCC-4 cell. The higher expression of RPSAP52 was positively correlated with higher T stage and TNM stage. Yes Ectopic expression of RPSAP52 induced TSCC cell growth and cycle and induced cytokine secretion including IFN-γ, IL-1β and IL-6, IL-8, IL-10 and TGF-β. 33787061 RPSAP52 LncRNA Homo sapiens Pituitary Neoplasms pituitary tissues Interaction[HMGA proteins] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Microarray We report that RPSAP52 expression is highly upregulated in gonadotroph and prolactin-secreting pituitary adenomas, where it correlates with that of HMGA2, compared with normal pituitary tissues. Yes Moreover, functional studies indicate that RPSAP52 promotes cell growth by enhancing the G1-S transition of the cell cycle. 31076808 hsa_circ_0001187 CircRNA Homo sapiens Colitis, Ulcerative UC patients Interaction(miR-1236-3p/MYD88 axis) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA//EdU Staining Circ_0001187 was overexpressed in UC patients. Our data confirmed that circ_0001187 facilitated UC progression through miR-1236-3p/MYD88 axis, which might be a potential treatment and diagnosis biomarker for UC. Yes Circ_0001187 knockdown enhanced the proliferation, while suppressed apoptosis, inflammation and oxidative stress of TNF-α-induced FHC cells. Circ_0001187 acted as miR-1236-3p sponge, and the effects of circ_0001187 downregulation on TNF-α-induced FHC cell injury were overturned by miR-1236-3p inhibitor. 35609334 circSETD3 CircRNA Homo sapiens Hepatoblastoma HB clinical tissues and cell lines Interaction(miR-423-3p/Bcl-2) In Vivo Experiment//RNA Pull-Down//Immunoblotting//qPCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay Here, we identified that circSETD3 downregulated in both HB clinical tissues and cell lines, compared to that of normal tissues and cells. Next, we validated that miR-423-3p targeted both circSETD3 and 3' untranslated region (3'UTR) of Bim, and circSETD3 positively regulated Bim in HB cells through sponging miR-423-3p in a competing endogenous RNA (ceRNA)-dependent manner. Yes Further gain-of-function experiments validated that circSETD3 overexpression inhibited cell proliferation, viability, migration, epithelial-mesenchymal transition (EMT) and tumorigenesis, and induced cell apoptosis in HB cells. 34659347 hsa_circ_0000594 CircRNA Homo sapiens Hepatoblastoma HB tissues Expression[ Mechanically, hsa_circ_0000594 was identified to have a critical role in HB development through the hsa_circ_0000594/mir-217/SIRT1 regulatory axis, which might become a novel diagnostic marker and potential therapeutic target in HB.] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Expression levels of hsa_circ_0000594 were significantly upregulated in HB tissues compared with those in paired normal liver tissues and showed a clear association with the subtype of HB. Mechanically, hsa_circ_0000594 was identified to have a critical role in HB development through the hsa_circ_0000594/mir-217/SIRT1 regulatory axis, which might become a novel diagnostic marker and potential therapeutic target in HB. Yes The knockdown of hsa_circ_0000594 inhibited the malignant phenotype of HB. 31646606 SNHG1 LncRNA Homo sapiens Thyroid Neoplasms PTC tissue,cell lines Interaction[SP1/SNHG1/miR-199a-5p] ChIP//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Among these candidate lncRNAs, SNHG1 was identified to be Expression[Expression[up-expression]-expression]-regulated in both PTC tissue and cells. Mechanistically, SNHG1 sponged miR-199a-5p by complementary binding with specificity protein 1 (SP1) 3'-UTR. Interestingly, transcription factor SP1 targeted the promoter region of SNHG1 to promote its transcriptional level. The interaction within lncRNA, miRNA and target mRNA constructed the feedback loop of SP1/SNHG1/miR-199a-5p/SP1 in PTC. Yes Functionally, knockExpression[down-expression] of SNHG1 repressed the proliferation, invasion and tumor growth in vitro and in vivo. 31791587 SNHG1 LncRNA Homo sapiens Atherosclerosis blood Regulation[miR-17-5p/NF-κB signaling pathway ] CCK8//qRT-PCR//ELISA//Luciferase Report Assay We found that SNHG16 was increased in AS patients and THP-1 macrophage-derived foam cells. Most importantly, we uncovered a previously unappreciated SNHG16/miR-17-5p/ NF-κB signaling axis in promoting proliferation and inflammatory response in AS patients and THP-1 macrophages, which might provide a potential target for treating AS. Yes Furthermore, SNHG16 overexpression promoted proliferation, inflammatory response and increased levels of IKKβ, p-IkBα, p-p65 in THP-1 macrophages, while SNHG16 downregulation led to the opposite results. 31646601 SNHG1 LncRNA Homo sapiens Glioblastoma U138MG cells Expression(Among them, 27 lncRNAs were identified as therapy-resistant lncRNAs that remained dysregulated after both radiotherapy and chemoradiotherapy; while 21 lncRNAs were identified as therapy-sensitive lncRNAs whose expressions were reversed by both radiotherapy and chemoradiotherapy.) Western Blot//Transfection//qRT-PCR//Microarray//Cell Proliferation Assay We identified 51 lncRNAs aberrantly expressed in GBM specimens compared with either normal brain samples or epilepsy non-tumor brain samples. Among them, 27 lncRNAs were identified as therapy-resistant lncRNAs that remained dysregulated after both radiotherapy and chemoradiotherapy; while 21 lncRNAs were identified as therapy-sensitive lncRNAs whose expressions were reversed by both radiotherapy and chemoradiotherapy. We further investigated the potential functions of the therapy-resistant and therapy-sensitive lncRNAs and demonstrated their relevance to cell proliferation. We also found that the expressions of several lncRNAs, including SNHG1 and UBL7-AS1, were positively correlated with cell-cycle genes' expressions. Finally, we experimentally confirmed the function of a therapy-resistant lncRNA, SNHG1, and a therapy-sensitive lncRNA, UBL7-AS1, in promoting cell proliferation in GBM U138MG cells. Our in vitro results demonstrated that knockdown of SNHG1 and UBL7-AS1 showed an additive effect in reducing cell proliferation in U138MG cells. Yes Among them, 27 lncRNAs were identified as therapy-resistant lncRNAs that remained dysregulated after both radiotherapy and chemoradiotherapy; while 21 lncRNAs were identified as therapy-sensitive lncRNAs whose expressions were reversed by both radiotherapy and chemoradiotherapy. 35313638 SNHG16 LncRNA Homo sapiens Colonic Neoplasms Regulation[miR-302a-3p/AKT Axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay Furthermore, the starBase database predicted that miR-302a-3p was the target gene of SNHG16, which was supported by dual luciferase assay. The effect of promoting cell proliferation ability induced by SNHG16 overexpression could be partly reversed by co-transfection of miR-302a-3p mimic. Application of the miRanda database indicated that AKT may be modulated by SNHG16, further evidenced by western blot and quantitative PCR assays. AKT overexpression could partly reverse the attenuated colon cancer cell growth caused by miR-302a-3p mimic transfection. Meanwhile, the combination of miR-302a-3p inhibitor and shAKT achieved the parallel result. In conclusion, our study revealed the SNHG16/miR-302a-3p/AKT axis might play a crucial role in colon cancer cell proliferation, thus participating in the process of colon cancer development. Yes In our study, with the aim to identify the role of SNHG16 on colon cell proliferation, SNHG16 was overexpressed or knocked down in vitro, respectively. SNHG16 overexpression accelerated colon cancer cell growth, while cell growth ability was impaired in SNHG16 silencing cells. 31502038 SNHG16 LncRNA Homo sapiens Lung Neoplasms lung cancer cells regulation[miR-520/VEGF axis] qRT-PCR//MTT//Transwell Assay Compared with normal cells, SNHG16 is highly expressed in lung cancer cells.LncRNA SNHG16 as ceRNA promotes the migration of lung cancer cells by regulating the miR-520/VEGF axis. Yes Silent SNHG16 has a negative effect on the migration of lung cancer cells. 33015794 SNHG16 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell lines Interaction(ALDH2) Western Blot//Wound Healing Assay//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Transwell Assay The results showed a significant (P < 0.05) transcriptional upregulation of SNHG16 in lung cancer tissues and cell lines. Bioinformatic analysis revealed that SNHG16 interacted with ALDH2 to exert its effects in human lung cancer cells. The expression of ALDH2 was found to be significantly (P < 0.05) suppressed in human lung cancer tissues and cell lines. Yes However, downregulation of SNHG16 resulted in significant (P < 0.05) inhibition of lung cancer A549 and SK-LU-1 cell proliferation. DAPI and annexin V/PI assays revealed apoptosis to be responsible for inhibition of cell proliferation and colony formation observed upon SNHG16 knockdown. This was accompanied by enhancement of Bax and suppression of Bcl-2 expression in A549 and SK-LU-1 cells. Transwell assays revealed that silencing of SNHG16 also significantly (P < 0.05) inhibited migration and invasion of A549 and SK-LU-1 cells. 35646120 SNHG16 LncRNA Homo sapiens Colorectal Neoplasms CC tissues and adjacent normal tissues Interaction[ sponging miR-200a-3p] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay A revealed that SNHG16 level was significantly higher in CRC tissues compared with normal tissues.MiR-200a-3p was inversely correlated with SNHG16 expression in CRC tissues. Yes Further, in vivo study also revealed that overexpression of SNHG16 could promote tumor growth. 30962265 SNHG16 LncRNA Homo sapiens Colorectal Neoplasms colorectal tumors or cells regulation[miR-124-3p/MCP-1] RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//H&E Staining//Transwell Assay SNHG16 and miR-124-3p were dysregulated in human colorectal tumors or cells. In summary, our data suggest that SNHG16 plays a contributory role in proliferation, migration, and EMT of CRC cells via miR-124-3p/MCP-1 axis, which offers a rationale for targeting SNHG16 and developing therapeutic drugs to treat CRC. Yes Knockdown of SNHG16 led to attenuate cell proliferation, migration, invasion, and EMT of CRC cells. And xenograft tumor experiment showed that SNHG16 might influence tumor growth. 32859986 SNHG16 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[SNHG16/miR-132-3p/USP22 pathway ] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay SNHG16 was highly expressed in CRC tissues and cells.The discovery of the SNHG16/miR-132-3p/USP22 pathway provided new thinking for the treatment of CRC. Yes Knockdown of SNHG16 reduced the proliferation, migration, invasion, and promoted the apoptosis of CRC cells. 32547062 SNHG16 LncRNA Homo sapiens Colorectal Neoplasms CTC tissues and cells Interaction(miR-195-5p/Ago2) qRT-PCR//RIP//ChIP Mechanistically, SNHG16 acted as a miRNA sponge to sequester miR-195-5p on Ago2, thereby protecting YAP1 from repression. Moreover, YAP1 bound TEA domain transcription factor 1 (TEAD1) to form a YAP1/TEAD1 complex, which in turn bound two sites in the promoter of SNHG16 and regulate SNHG16 transcription. Yes Finally, in vivo experiments showed that the inhibition of SNHG16 suppressed tumor progression, and that YAP1 rescued the effect of SNHG16 on tumor progression. Furthermore, loss- and gain-of-function assays revealed that SNHG16 promoted CRC colony formation, proliferation, migration, invasion, EMT, mesenchymal-like CTC generation, and liver metastasis through YAP1. 36147462 SNHG16 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-214-3p/ABCB1 ) qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis SNHG16 was found to be significantly elevated in human CRC tissues and cell lines.Mechanistically, we identified that SNHG16 is expressed predominantly in the cytoplasm. SNHG16 could interact with miR-214-3p and up-regulated its target ABCB1. Yes Functional studies suggested that SNHG16 promoted CRC cell growth both in vitro and in vivo. 35965433 SNHG16 LncRNA Homo sapiens Carcinoma, Hepatocellular Hepatocellular Carcinoma tissues Interaction[Regulating miR-186] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our findings showed for the first time that SNHG16 was up-regulated in HCC tissues and cell lines. Further molecular mechanism studies reported that the expression of SNHG16 was negatively correlated with the level of miR-186 and SNHG16 directly bound to miR-186. SNHG16 and miR-186 repressed each other. Notably, rescue experiments were conducted and showed that miR-186 reversed the effect of SNHG16 on cell. The expression of SNHG16 in cancer tissues was highly correlated with tumor size, TNM stage, ALT expression level and HBV DNA level. Yes As revealed by our data, SNHG16 accelerated the proliferation, migration and invasion of HCC cell. SNHG16 facilitated tumor formation in vivo 31293662 SNHG16 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Lung cancer tissues and adjacent normal tissues,cell lines(A292，NCI-H460，NCI-H1703,NCI-H16) Expression[highly expressed] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//ELISA In this study, we report that lncRNA SNHG16 is upregulated in non-small cell lung cancer (NSCLC) tissues, and correlates with tumor size, TNM stage and lymph node metastasis. Kaplan-Meier analysis shows that the patients with high SNHG16 expression have poorer disease-free survival (DFS) and overall survival (OS) than the patients with low SNHG16 expression. Multivariate Cox regression analysis reveals that SNHG16 expression could be regarded as an independent predictor for DFS and OS in NSCLC patients. Yes Cell experiments show that SNHG16 promotes NSCLC cell proliferation, migration and invasion. miR-146a is further identified and confirmed to be the target of SNHG16, and SNHG16 functions by targeting miR-146a. 30287374 SNHG16 LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues,cell lines Interaction[ miR-195] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay In our study, our observations showed that the expression level of SNHG16 in HCC tissues and cell lines was upregulated compared with adjacent noncancerous tissues and normal cells. miR-195 expression was significantly decreased in HCC tissues and negatively correlated with SNHG16 expression. Furthermore, RIP and dual luciferase reporter assays showed that SNHG16 acted as an endogenous sponge by directly binding to miR-195 and downregulated its expression. SNHG16 overexpression inverted the inhibitory effect of miR-195 on proliferation and invasion of SMMC7721 and HepG2 cells. Additionally, SNHG16 depletion resulted in lower tumor growth and weight loss, in vivo. Yes n vitro, loss-of-function experiments revealed that SNHG16 knockdown suppressed the proliferation and weakened invasion of SMMC7721 and HepG2 cells. 31306653 SNHG16 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[regulating p62] Western Blot//Wound Healing Assay//Flow Cytometry//FISH//qRT-PCR//MTT//Luciferase Report Assay//Microarray//Transwell Assay LncRNA SNHG16 is upregulated in HCC and correlates with poorer prognosis.Altering SNHG16 expression altered levels of miR-17-5p, which in turn modified expression of p62, which has been shown to regulate the mTOR and NF-κB pathways. Indeed, altering SNHG16 expression in HCC cells activated mTOR and NF-κB signaling. These results reveal a potential mechanism for the oncogenic role of SNHG16 in HCC. SNHG16 may therefore be a promising diagnostic marker as well as therapeutic target in HCC. LncRNA SNHG16 is upregulated in HCC and correlates with poorer prognosisPatients with high SNHG16 expression showed lower rates of overall and disease-free survival than patients with low SNHG16 expression. Multivariate Cox regression revealed that SNHG16 expression was an independent predictor of poor overall and disease-free survival. Yes In vitro, SNHG16 promoted HCC cell proliferation, migration, and invasion while inhibiting apoptosis; in vivo, it accelerated tumor development. 31256427 SNHG16 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Expression[highly expressed] qRT-PCR We found that SNHG16 was upregulated in HCC tissues and cell lines and that it was negatively correlated with survival time in HCC patients. We found that SNHG16 was upregulated in HCC tissues and cell lines and that it was negatively correlated with survival time in HCC patients. Yes Furthermore, downregulation of SNHG16 inhibited proliferation, migration, invasion. 30893293 SNHG16 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Regulation[miR-4500/STAT3 axis] qRT-PCR In this study, our results delineated that SNHG16 presented much higher expression levels in HCC tissues and cells, particularly in advanced stages of HCC. In other words, this study was the first to investigate the potential mechanism of SNHG16 in HCC and verified SNHG16 exerted its carcinogenesis by miR-4500/STAT3 axis, suggesting SNHG16 may be a new underlying therapeutic target for HCC treatment. Enhanced SNHG16 expression was strongly related to poor prognosis.  Yes SNHG16 facilitated HCC progression by promoting cell proliferation, migration, invasion, and epithelial-mesenchymal transition process as well as inhibiting cell apoptosis. 30779219 SNHG16 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Regulation[let-7b-5p/CDC25B/CDK1 axis ] qRT-PCR The results revealed that SNHG16 was highly expressed in HCC tissues and cell lines, which predicted poor prognosis of HCC patients. SNHG16 facilitated the G2/M cell cycle transition by directly acting on the let-7b-5p/CDC25B/CDK1 axis, and promoted cell metastasis and EMT progression by regulating the let-7b-5p/HMGA2 axis in HCC. Yes On one hand, the downregulation of SNHG16 induced G2/M cell cycle arrest, inducing cell apoptosis and suppression of cell proliferation. On the other hand, it inhibited cell metastasis and EMT progression demonstrated by in vitro loss-of-function cell experiments. Besides, knockdown of SNHG16 increased the sensitivity of HCC cells to cisplatin. 31696971 SNHG16 LncRNA Homo sapiens Carcinoma, Hepatocellular tumor tissues and HCC cell line Expression(highly expressed) qRT-PCR//Cell Viability Assay SNHG16 expression was upregulated in tumor tissues and HCC cell lines.Mechanistic analyses indicated that the ECM-receptor interaction pathway was remarkably activated by SNHG16. High expression of SNHG16 was associated with tumor recurrence and poor prognosis after surgery. Yes Moreover, inhibition of SNHG16 in HepG2, Hep3B, and BEL-7402 cells significantly reduced cell invasiveness and proliferation. 34600815 SNHG16 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miR-942-3p/MMP9 ) qRT-PCR Exosomal LncSNHG16 was phagocytized by TCs and downregulated miR-942-3p, which induced targeted MMP9 upregulation, and it had specific binding sites with miR-942-3p in TCs to facilitate the migration of HCC cells in vitro and in vivo. Exosomal LncSNHG16 was found to act as a competing endogenous RNA of the miR-942-3p/MMP9 axis in TCs. Yes Exosomal LncSNHG16 was phagocytized by TCs and downregulated miR-942-3p, which induced targeted MMP9 upregulation, and it had specific binding sites with miR-942-3p in TCs to facilitate the migration of HCC cells in vitro and in vivo. 36434360 MANCR LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cells Expression(highly expressed) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay MANCR was significantly upregulated in LUAD cells. It also resulted in a poor prognosis. Yes When MANCR expression was down-regulated, the expression of proteins related to invasion and migration, cell cycle and proliferation was decreased, while the expression of proteins associated with apoptosis was elevated. Furthermore, in vitro experiments revealed that silencing MANCR inhibited cancer cell functions, blocked cell cycle progression while promoting cell apoptosis. 34418982 SNHG16 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[miR-520a-3p/EphA2 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay We found that SNHG16 was upregulated in NSCLC tissues and cell lines, knockdown of SNHG16 inhibited cell proliferation, migration, invasion and induced apoptosis in vitro as well as suppressed tumor growth in vivo. SNHG16 promoted NSCLC development by regulating the miR-520a-3p/EphA2 axis, suggesting novel insights for the pathogenesis of NSCLC and new potential therapeutic targets for the treatment of NSCLC. Yes We found that SNHG16 was upregulated in NSCLC tissues and cell lines, knockdown of SNHG16 inhibited cell proliferation, migration, invasion and induced apoptosis in vitro as well as suppressed tumor growth in vivo. 31953899 SNHG16 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-892b/PPAPDC1A Axis) Western Blot//RIP//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC This study demonstrated that SNHG16 expression was significantly increased in BC tissues and cells. Bioinformatics analysis predicted that SNHG16 regulated PPAPDC1A expression by sponging miR-892b, which was confirmed by RNA-fluorescence in situ hybridization (FISH), RT-qPCR, dual-luciferase gene reporter assay, and RNA immunoprecipitation (RIP).In conclusion, EVs derived from BC cells transferred SNHG16 via the miR-892b/PPAPDC1A axis, thus promoting EMT, migration, and invasion of BC. Yes Overexpression of SNHG16 promoted the migration, invasion, and epithelial-mesenchymal transition (EMT) of BC cells. The results confirmed that enhanced miR-892b expression partially eliminated the increase of migration, invasion, and EMT of BC cells mediated by SNHG16 or EVs. The lung metastasis model in nude mice was established by injecting HS578T cells via tail vein. The results showed that si-SNHG16 reduced the metastatic nodules and decreased the vimentin expression. 34249903 SNHG16 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction[c-Myc ] qRT-PCR In this paper, we found that c-Myc and SNHG16 were overexpressed in OSCC tissues and cell lines compared with normal tissues and normal human oral keratinocytes cells. Moreover, depletion of SNHG16 induced cell apoptosis and inhibited epithelial-to-mesenchymal transition as indicated by induction of cleaved caspase-3 and epithelial cadherin (E-cadherin) along with reduction of N-cadherin and Snail. Intriguingly, c-Myc knockdown led to the similar functional effects as that of SNHG16 knockdown in TSCCA cells. However, these changes caused by c-Myc knockdown were abrogated by SNHG16 overexpression. Similarly, silencing of c-Myc markedly inhibited tumor growth and reduced SNHG16 expression in nude mice. Moreover, overexpression of SNHG16 blocked the inhibitory effect of c-Myc silencing on tumor growth in vivo. Thus, we conclude that c-Myc-induced upregulation of SNHG16 enhances progression and carcinogenesis in OSCC. Yes Depletion of SNHG16 in CAL-27 cells strikingly inhibited cell proliferation, migration and invasion, as indicated by downregulation of proliferating cell nuclear antigen (PCNA), matrix metalloproteinase (MMP)-2 and MMP-9. Knockdown of SNHG16 conspicuously repressed tumor growth in nude mice. 30607006 SNHG17 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(microRNA-193a-5p/NETO2 axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis//Transwell Assay The results demonstrated that SNHG17 expression was significantly upregulated in LUAD tissues and cells, and high SNHG17 expression was associated with tumor-node-metastasis stage and poor prognosis of patients with LUAD. In addition, the results revealed that SNHG17 functions as a competing endogenous RNA of miR-193a-5p. The results of the dual-luciferase reporter assay confirmed that miR-193a-5p can directly target SNHG17. NETO2 was also predicted as a target protein of miR-193a-5p, which was confirmed via the dual-luciferase reporter assay. The results demonstrated that SNHG17 expression was significantly upregulated in LUAD tissues and cells, and high SNHG17 expression was associated with tumor-node-metastasis stage and poor prognosis of patients with LUAD. Yes SNHG17 knockdown inhibited cell migration, invasion, proliferation and the EMT process. 34671432 SNHG17 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissue regulation[FOXA1] CCK8//qRT-PCR//Western Blot//Transwell Assay qRT-PCR results indicated that SNHG17 expression was remarkably enhanced in ovarian cancer tissue samples compared with that in adjacent ones. LncRNA SNHG17 can promote ovarian tumor cell proliferative ability and invasiveness by upregulating FOXA1, and serve as a potential therapeutic target for ovarian cancer. Yes However, down-regulating SNHG17 attenuated the cell proliferation and invasive ability. 33015769 SNHG17 LncRNA Homo sapiens Ovarian Neoplasms EOC cells Interaction(miR-485-5p/AKT1 axis) Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay SNHG17 knockdown reduced the proliferation and promoted the apoptosis of EOC cells.MiR-485-5p was proved to be the target miRNA of SNHG17, and SNHG17 negatively regulated the level of miR-485-5p. MiR-485-5p inhibitor significantly abolished the anti-tumor impact of si-SNHG17 on EOC. AKT1 was identified to be targeted by miR-485-5p, and miR-485-5p negatively modulated AKT1 and p-mTOR levels. Moreover, miR-485-5p mimics reduced the proliferation, migration and promoted the apoptosis of EOC cells via targeting AKT1. Yes Consistently, si-SNHG17 obviously reduced the invasion and epithelial-to-mesenchymal transition (EMT) process of EOC cells. Furthermore, si-SNHG17 markedly suppressed EOC growth in vivo. 36399797 SNHG17 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cell lines Interaction(miR-384/ELF1 axis ) Tunel//CCK8//qRT-PCR//Colony Formation Assay//EdU Staining Herein, SNHG17 was disclosed to be remarkably upregulated in OSCC cell lines and promoted OSCC cell growth. Collectively, it can be concluded that SNHG17/miR-384/ELF1 axis contributed to OSCC cell growth via promoting CTNNB1 expression, thus activating Wnt/β-catenin signaling pathway. Yes Herein, SNHG17 was disclosed to be remarkably upregulated in OSCC cell lines and promoted OSCC cell growth. 33531646 SNHG17 LncRNA Homo sapiens Osteosarcoma Five pairs of primary OS adjacent tumor-free tissues and tumor tissues Interaction(miR-2861) qRT-PCR//RIP//Migration Assay We found that SNHG17 was upregulated in the tumor tissues and presented a pro-tumorigenic effect on OS both in vitro and in vivo. CAFs-released exosomal SNHG17 acted as an essential molecular sponge for miR-2861 in OS cells. Yes It also was an essential exosomal cargo of CAFs and could affect OS cell proliferation and migration in vitro. 34650683 SNHG17 LncRNA Homo sapiens Uterine Cervical Neoplasms serum of CC patients Interaction(microRNA-375-3p) Bioinformatics Analysis//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Invasion Assay SNHG17 showed an ascending expression while miR-375-3p descended in the serum of CC patients. Serum SNHG17 expression was negatively correlated with miR-375-3p expression, and miR-375-3p was the target miRNA of SNHG17. Yes Knockdown of SNHG17 inhibited proliferation, migration, and invasion of CC cells. 34188550 SNHG17 LncRNA Homo sapiens Glioma glioma tissues regulation[miR-23b-3p/ZHX1 axis] CCK8//qRT-PCR//Western Blot//Transwell Assay "SNHG17 expression was markedly raised in glioma tissues, which was positively correlated with ZHX1 expression and negatively associated with the expression of miR-23b-3p. SNHG17 is a ""competing endogenous RNA"" with respect to modulating ZHX1 expression by adsorbing miR-23b-3p and thereby promoting glioma progression." Yes After transfection of SNHG17 shRNAs into glioma cells, the proliferation, migration and invasion of cancer cells was markedly restrained. 32602607 SNHG17 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-506-3p/CTNNB1 axis,Wnt/β-catenin signaling pathway] RNA Pull-Down//Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining SNHG17 expression was up-regulated in glioma tissues and cells.The findings that YY1-induced SNHG17 facilitated the glioma progression through targeting miR-506-3p/CTNNB1 axis to activate Wnt/β-catenin signaling pathway offered a brand-new prospects to molecular-targeted treatment for glioma. Yes SNHG17 silence attenuated cell proliferation and promoted apoptosis and repressed tumor growth. 32009853 SNHG17 LncRNA Homo sapiens Adenocarcinoma of Lung cell lines interaction[sponging miR-485-5p] RNA Pull-Down//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay SNHG17 and WLS were up-regulated in LUAD cell lines. Yes SNHG17 curbed LUAD cell proliferation, migration and invasion but facilitated apoptosis. SNHG17 acted as miR-485-5p sponge to upregulate WLS expression. 33109341 SNHG17 LncRNA Homo sapiens Adenocarcinoma of Lung NSCLC tissues Interaction( lncRNA MIR503HG/SNHG17/miR-330-3p/regulatory axis) CCK8//qRT-PCR//Transfection//migration assay Finally, we identified the upstream regulatory axis of IRRGs in NSCLC, namely, lncRNA MIR503HG/SNHG17/miR-330-3p/regulatory axis. Yes Finally, knockdown of SNHG17 expression inhibited lung adenocarcinoma (LUAD) cell proliferation and migration. 35719962 SNHG16 LncRNA Homo sapiens Breast Neoplasms breast cancer tissue regulation[SNHG16/miR-30a axis ] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Recent studies have reported that the lncRNA small nucleolar RNA host gene 16 (SNHG16) is highly expressed in breast cancer tissue. Our results indicated that the SNHG16/miR-30a axis regulated the expression of ribonucleotide reductase M2 (RRM2) in breast cancer cells. Yes We found that SNHG16 inhibition reduced the proliferation and invasion of breast cancer cells in vitro. 32122142 SNHG17 LncRNA Homo sapiens Rectal Neoplasms rectal cancer tissues and cells Interaction(miR-361-3p/STC2 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Bioinformatics Analysis The upregulation status of SNHG17 was identified in rectal cancer tissues and cells. Furthermore, we showed that microRNA-361-3p (miR-361-3p) has decreased expression in tumor tissues and cells, and SNHG17 functions as a sponge for miR-361-3p. Yes Functionally, knockdown the expression of SNHG17 inhibits rectal cancer cell proliferation via stimulating cell apoptosis. In vivo assay showed that the knockdown of SNHG17 inhibits tumor growth. 34249085 SNHG17 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues interaction[SNORA71B] RNA Pull-Down//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//ChIP Results depicted that transcript 6 of SNHG17 and SNORA71B were upregulated in PC. In conclusion, current study first revealed that lncRNA SNHG17 aggravated prostate cancer progression through regulating its homolog SNORA71B via a positive feedback loop, which might do help to the pursuit of better PC treatment. Yes Knockdown of SNHG17 or SNORA71B weakened proliferation, invasion, migration, and epithelial-to-mesenchymal transition (EMT) and strengthened apoptosis. 32447342 SNHG17 LncRNA Homo sapiens Prostatic Neoplasms CRPC tissues and cells regulation[miR-144/CD51 Axis] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Transwell Assay Our results further confirmed that both SNHG17 and CD51 were up-regulated in CRPC tissues and cells. Taken together, our study reveals the role of the SNHG17/miR-144/CD51 axis in accelerating CRPC cell proliferation and invasion, and suggests that SNHG17 may serve as a novel therapeutic target for CRPC. Yes Functionally, down-regulation of SNHG17 or up-regulation of miR-144 inhibited the proliferation, migration, and invasion of CRPC cells, whereas up-regulation of SNHG17 and down-regulation of miR-144 promoted the proliferation, migration and invasion of CRPC cells in vitro and in vivo. 32351538 SNHG17 LncRNA Homo sapiens Prostatic Neoplasms PCa tumor and cell lines Expression [highly expressed] qRT-PCR//Invasion Assay//Western Blot The clinicopathological analysis revealed that SNHG17 mRNA expression level was increased in the PCa tumor samples, and its high expression levels were associated with poor patient outcomes, indicating that SNHG17 may act as a biomarker for the prognosis of PCa. SNHG17 mRNA expression level was also increased in different PCa tumor cell lines. its high expression levels were associated with poor patient outcomes Yes Functionally, SNHG17 increased C4-2 tumor cell growth and aggressiveness by stimulating tumor cell proliferation, survival, invasion and resistance to chemotherapy. Furthermore, SNHG17 promoted in vivo tumor growth in a xenograft mouse model. 33907582 SNHG17 LncRNA Homo sapiens Melanoma melanoma tissues and cells Expression[highly expressed] qRT-PCR High expressions of SNHG17 were observed in both melanoma tissues and cells. Up-regulation of SNHG17 in melanoma patients was associated with lymph node metastasis and tumor stage. Survival assays revealed that those patients with high SNHG17 expression had significantly shorter survival time. SNHG17 was also confirmed to be independently associated with overall survival of melanoma patients. Yes . Functional studies confirmed that the proliferation, migration, and invasion of melanoma cells were noticeably reduced by the down-regulation of SNHG17. 31599425 SNHG17 LncRNA Homo sapiens Pancreatic Carcinoma human PC specimens and cell lines Interaction(miR-942) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//MTT//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay SNHG17 expression was markedly higher in human PC specimens and cell lines than in normal healthy tissues and pancreatic epithelial cells. MiR-942 expression displayed the opposite trend. Bioinformatics prediction and a dual luciferase reporter assay confirmed that SNHG17 serves as a sponge for miR-942. Yes Loss-of-function assay revealed that SNHG17 silencing reduced the proliferation and viability of PC cells, impaired their migratory and invasive capacities, and led to their apoptosis. All these changes could be reversed by miR-942 inhibition. Further mechanical studies showed that SNHG17 silencing decreased the expression of several tumor modulators, including XXX, and this decrease was countered by miR-942 inhibition.  33841638 SNHG17 LncRNA Homo sapiens Colonic Neoplasms COAD tissues and cells regulation[SNHG17/miR-375/CBX3] qRT-PCR//RNA Pull-Down//Luciferase Report Assay We showed SNHG17 was upregulated expression in COAD tissues and cells.In conclusion, we demonstrated a novel SNHG17/miR-375/CBX3 triplets that participates in COAD progression, which may provide promising therapeutic targets for COAD. Yes Functionally, SNHG17 could promote COAD cell proliferation, colony formation, migration, and invasion in vitro. 33042419 SNHG16 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[JAK2/STAT3 pathway] Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay The expression level of SNHG16 in GC cell lines (BGC823, MGC803, MKN45, SGC7901) were all up regulated in different degrees.In addition, the expression level of SNHG16 in GC tissues was measured by qRT-PCR (Fig. ​Fig.11C) and results showed that SNHG16 was up-regulated in GC tissues compared with normal tissues. Collectively, it was suggested that SNHG16 can serve as a miR-135a sponge and block the function of miR-135a in JAK2/STAT3 pathway. Yes SNHG16 gene knockdown experiment indicated that the expression level of SNHG16 can influence GC cells proliferation, colony formation, invasion ability and apoptosis in a miR-135a dependent manner. 30854107 SNHG16 LncRNA Homo sapiens Urinary Bladder Neoplasms tissues and cell lines of bladder cancer Regulation(p21) qRT-PCR It was discovered that the level of SNHG16 was evidently enhanced both in tissues and cell lines of bladder cancer. Finally, mechanism experiments revealed that SNHG16 could epigenetically silence the expression of p21. Patients with highly expressed SNHG16 suffered from poor overall survival. Multivariable Cox proportional hazards regression analysis implied that highly expressed SNHG16 could be used as an independent prognostic marker. Yes It could be known from functional assays that silenced SNHG16 impaired cell proliferation, owing to the effects of SNHG16 on cell cycle and apoptosis. 29234154 SNHG16 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction(miR-17-5p/CCND1 axis ) CCK8//qRT-PCR LncRNA SNHG16 and CCND1 were upregulated, while miR-17-5p was downregulated in OSCC tissues and cell lines, compared to their normal counterparts. Also, miR-17-5p negatively correlated with both LncRNA SNHG16 and CCND1 mRNA, but LncRNA SNHG16 was positively relevant to CCND1 mRNA in OSCC tissues. Furthermore, our dual-luciferase reporter gene system evidenced that LncRNA SNHG16 sponged miR-17-5p to upregulate CCND1 in OSCC cells, and the inhibiting effects of LncRNA SNHG16 ablation on OSCC progression were abrogated by both downregulating miR-17-5p and overexpressing CCND1. Yes By performing the gain- and loss-of-function experiments, we noticed that LncRNA SNHG16 overexpression aggravated the malignant phenotypes, such as cell proliferation, viability, migration and epithelial-mesenchymal transition (EMT) in OSCC cells, while LncRNA SNHG16 knock-down had opposite effects. 33654431 SNHG17 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression(highly expressed) Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Invasion Assay Our data showed that SNHG17 expression was significantly upregulated in cancer regions of HCC compared with adjacent regions. Increased SNHG17 expression level was correlated with tumor size, TNM stage and poor survival prognosis in HCC patients. Yes Further functional experiments indicated that inhibition of SNHG17 significantly inhibited HCC cell proliferation, migration and invasion, caused cell cycle G0/G1 phase arrest and apoptosis. 34227089 SNHG16 LncRNA Homo sapiens Diabetic Retinopathy hRMECs Interaction(microRNA (miR)-146a-5p and miR-7-5p/IRAK1/IRS1) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Tube Formation Assay//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//ELISA//Transwell Assay We found that SNHG16 expression was significantly upregulated in hRMECs treated with HG. Moreover, SNHG16 was associated with nuclear factor κB (NF-κB) and phosphatidylinositol 3-kinase (PI3K)/AKT pathways. Mechanistically, SNHG16 could promote hRMEC dysfunction by sequestering microRNA (miR)-146a-5p and miR-7-5p to act as a competing endogenous RNA (ceRNA) with interleukin-1 receptor-associated kinase 1 (IRAK1) and insulin receptor substrate 1 (IRS1). Yes Functionally, SNHG16 could facilitate hRMEC proliferation, migration, and angiogenesis. 33898104 SNHG16 LncRNA Homo sapiens prostate carcinoma prostate carcinoma tissues regulation[GLUT1 ] Cell Proliferation Assay//qRT-PCR Overexpression of lncRNA-SNHG16 effectively distinguished prostate carcinoma patients from normal ones. Yes lncRNA-SNHG16 siRNA silencing also significantly inhibited prostate carcinoma cell proliferation. 32210616 SNHG16 LncRNA Homo sapiens Neuroblastoma NB tissues Expression[highly expressed] Wound Healing Assay//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Transwell Assay Analysis of NB tissue samples (Table I) revealed that SNHG16 expression was increased alongside clinical staging of NB tumor progression (Fig. 1F) and in MYCN-amplified NB (Fig. 1G). The expression of SNHG16 was revealed to be in line with the clinical staging of NB, and high SNHG16 expression was positively associated with poor clinical outcome. Yes Furthermore, SNHG16 silencing inhibited cell proliferation, repressed migration, and induced cell cycle arrest at the G0/G1 phase in SH‑SY5Y cells. Additionally, apoptosis was undetectable in SH‑SY5Y cells following SNHG16 silencing. 31180520 SNHG16 LncRNA Homo sapiens Neuroblastoma neuroblastoma tissues and cells regulation[miR-15b-5p/PRPS1 axis] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay We found SNHG16 and PRPS1 levels were increased in neuroblastoma tissues and cells. In conclusion, SNHG16 downregulation suppressed neuroblastoma tumorigenicity by regulating cell cycle, proliferation, and metastasis via miR-15b-5p/PRPS1 axis. Yes SNHG16 knockdown inhibited cell proliferation, increased the cell cycle distribution at G0/G1 phase, and decreased the cells at S phase. SNHG16 overexpression caused an opposite effect. SNHG16 silence suppressed neuroblastoma cell metastasis. PRPS1 knockdown constrained cell proliferation and metastasis and regulated cell cycle distribution. 33105440 SNHG16 LncRNA Homo sapiens Neuroblastoma NB tissues regulation[SNHG16/miR-542-3p/HNF4α axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Our data revealed that SNHG16 and hepatocyte nuclear factor 4 α (HNF4α) were up-regulated, but miR-542-3p was down-regulated in NB. Therefore, SNHG16/miR-542-3p/HNF4α axis modified NB progression via RAS/RAF/MEK/ERK signaling pathway, might highlight a novel therapeutic approach for NB. Yes Knockdown of SNHG16 or HNF4α could impede cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro. 32412051 SNHG16 LncRNA Homo sapiens Neuroblastoma NB tissues and cells interaction[miR-542-3p,ATG5 ] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay SNHG16 was upregulated in NB tissues and cells and associated with clinical stage and poor prognosis of NB. SNHG16 facilitated proliferation, migration, invasion and autophagy of NB cells via sponging miR-542-3p and upregulating ATG5 expression in NB. Yes Knockdown of SNHG16 impeded proliferation, migration, invasion and autophagy of NB cells in vitro, and suppressed tumor growth in vivo. 32021273 SNHG16 LncRNA Homo sapiens Neuroblastoma NB tissues and cells regulation[SNHG16/miR-128-3p/HOXA7 axis] Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay The levels of SNHG16 and HOXA7 were conspicuously increased in NB tissues and cells, while the expression of miR-128-3p was obviously declined, compared with corresponding normal tissues and cells. Knockdown of SNHG16 impeded proliferation, migration, invasion and induced apoptosis through the SNHG16/miR-128-3p/HOXA7 axis in NB cells. Yes SNHG16 silencing inhibited proliferation, migration and invasion and induced apoptosis of NB cells. 31919621 SNHG16 LncRNA Homo sapiens Leukemia cell lines regulation[miR-193a-5p/CDK8] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay SNHG16 was found to be abnormally highly expressed in acute myeloblastic leukemia cell lines, the knockdown of which weakened the viability of the leukemia cells, suppressed cell proliferation and promoted cell apoptosis.The knockdown of SNHG16 suppressed the viability of the leukemia cells, suppressed cell proliferation, and induced cell apoptosis by regulating miR‑193a‑5p/CDK8. Yes SNHG16 was found to be abnormally highly expressed in acute myeloblastic leukemia cell lines, the knockdown of which weakened the viability of the leukemia cells, suppressed cell proliferation and promoted cell apoptosis. 32705162 SNHG16 LncRNA Homo sapiens Precursor Cell Lymphoblastic Leukemia-Lymphoma blood Interaction[hsa-miR-124-3p] qPCR//Luciferase Report Assay SNHG16 gene expression was evaluated by quantitative real-time PCR (qPCR) in both in vitro ALL cell lines and in vivo human samples of T lymphocytes. Hsa-miR-124-3p was inhibited in SNHG16-downregulated MOLT3 and SUP-B15 cells to further evaluate the functional correlation between SNHG16 and hsa-miR-124-3p in ALL. SNHG16 is upregulated in both in vitro ALL cell lines and in vivo human leukemic T-cells. SNHG16 downregulation suppressed ALL proliferation and migration in vitro, and ALL explant in vivo. Hsa-miR-124-3p was demonstrated to interact with SNHG16, and upregulated in SNHG16-downregulated ALL cells. Yes Lentivirus-mediated SNHG16 downregulation was performed in MOLT3 and SUP-B15 cells, to evaluate its functional effects on ALL cell proliferation, migration in vitro, and ALL transplant in vivo. 30380185 SNHG16 LncRNA Homo sapiens pneumonia blood Regulation[miR-370-3p/IGF2 axis] CCK8//qRT-PCR//ELISA//RIP SNHG16 and IGF2 were upregulated while miR-370-3p was downregulated in serum of acute pneumonia patients and LPS-induced A549 cells. SNHG16 impeded cell viability and promoted apoptosis, inflammatory injury by targeting IGF2 mediated by miR-370-3p in LPS-induced A549 cells. Yes SNHG16 regulated proliferation, apoptosis and inflammatory cytokines by inhibiting miR-370-3p in LPS-induced A549 cells. 31841752 SNHG16 LncRNA Homo sapiens Melanoma melanoma tissues and cells Interaction(miR-205-5p/PAK2 Axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay Here, we found that SNHG16 was up-regulated in melanoma. NHG16 can promote the expression of P21-activated kinases 2 (PAK2) by sponging miR-205-5p. PAK2 is the target gene of miR-205-5p. We demonstrated that SNHG16 promotes the metastasis and growth of melanoma through miR-205-5p/PAK2 axis. Yes SNHG16 enhances the growth and metastasis of melanoma. 35983126 hsa_circ_0066715 CircRNA Homo sapiens Arthritis, Rheumatoid macrophage Interaction(miR-486-5p) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//RIP//FISH//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay Here, we show that RA was closely associated with low expression of circ_0066715. Interestingly, the overexpression of miR-486-5p significantly suppressed the attenuation of the cell function and the effect on M1 macrophage polarization caused by circ_0066715 positive expression. WTAP may be involved in the methylation process of ETS1 in RA. ETS1 m6A methylation levels were altered upon WTAP intervention. The overexpression or interference of circ_0066715 decreased or increased WTAP expression. Yes The overexpression of circ_0066715 significantly increased the ETS1 levels in RA-FLS cells, decreased cytokine secretion by M1-type macrophages, elevated M2-type cytokines, and inhibited FLS proliferation. 36541909 SNHG16 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(EIF4A3/RhoU) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Colony Formation Assay//qRT-PCR//FISH//RIP//RNA-seq//IHC SNHG16 was highly expressed in ESCC and intraepithelial neoplasia (IEN) samples, and its expression level was correlated with tumour differentiation and T stage. Mechanistically, we noticed that SNHG16 could bind RNA binding protein (RBP)-eukaryotic translation initiation factor (EIF4A3) and interact with it to form a complex. Importantly, the coalition of SNHG16 and EIF4A3 ultimately regulated Ras homologue family member U (RhoU). SNHG16 modulated RhoU expression by recruiting EIF4A3 to regulate the stability of RhoU mRNA. Knockdown of RhoU further alleviated the effect of the SNHG16 oncogene in ESCC cells. SNHG16 was highly expressed in ESCC and intraepithelial neoplasia (IEN) samples, and its expression level was correlated with tumour differentiation and T stage. Yes Overexpression of SNHG16 can facilitate ESCC cell proliferation and metastasis. 36221055 Snhg16 LncRNA Mus musculus Osteoarthritis OA tissue Interaction(miR‑373‑3p) Western blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay lncRNA SNHG16 was upregulated in OA tissue compared with normal joint tissue. Furthermore, the luciferase activity assay suggested that SNHG16 negatively regulated miR‑373‑3p in OA. Finally, the results suggested that the proinflammatory effect of IL‑1β on CHON‑001 cells was significantly reduced by SNHG16 knockdown. Yes SNHG16 knockdown significantly increased the expression levels of aggrecan, and decreased the expression levels of MMP13, cleaved caspase?3 and p21 in IL?1β?treated CHON?001 cells. In addition, IL?1β induced CHON?001 cell apoptosis, while SNHG16 knockdown decreased IL?1β?induced apoptosis. 33300061 hsa_circ_0044235 CircRNA Homo sapiens Arthritis, Rheumatoid plasma Expression(highly expressed) qRT-PCR Hsa-circ0044235 was found to be significantly decreased in plasma from patients with new-onset RA compared with HC and OA + UA patients, but was significantly increased compared with SLE patients. The expression of plasma hsa-circ0000175 in new-onset RA patients was associated with platelet count (PLT), plateletcrit (PCT), and platelet large cell ratio (PLR), the expression of plasma hsa-circ0044235 new-onset RA patients was associated with swollen joint count (SJC), painful joint count (PJC), and disease activity score 28 (DAS28). ROC curve analysis suggested that the combination of hsa-circ0000175 and hsa-circ0044235 has some value in the diagnosis of new-onset RA from HC, patients with SLE and patients with OA + UA. The logistic regression analysis revealed that the expression of hsa-circ0000175 and hsa-circ0044235 in plasma were risk factors for RA. This study suggests that the combination of plasma hsa-circ0000175 and hsa-circ0044235 improves the diagnostic accuracy for new-onset RA. Moreover, the expression levels of plasma hsa-circ0000175 and hsa-circ0044235 were associated with disease activity and severity of RA. the expression of plasma hsa-circ0044235 new-onset RA patients was associated with swollen joint count (SJC), painful joint count (PJC), and disease activity score 28 (DAS28). ROC curve analysis suggested that the combination of hsa-circ0000175 and hsa-circ0044235 has some value in the diagnosis of new-onset RA from HC, patients with SLE and patients with OA + UA. The logistic regression analysis revealed that the expression of hsa-circ0000175 and hsa-circ0044235 in plasma were risk factors for RA. Yes We confirmed that hsa-circ0000175 was significantly elevated in plasma from patients with new-onset RA compared with HC and patients with new-onset SLE, but significantly was reduced when compared with OA + UA patients. 34008433 hsa_circ_0000175 CircRNA Homo sapiens Arthritis, Rheumatoid plasma Expression(highly expressed) qRT-PCR Hsa-circ0044235 was found to be significantly decreased in plasma from patients with new-onset RA compared with HC and OA + UA patients, but was significantly increased compared with SLE patients. The expression of plasma hsa-circ0000175 in new-onset RA patients was associated with platelet count (PLT), plateletcrit (PCT), and platelet large cell ratio (PLR), the expression of plasma hsa-circ0044235 new-onset RA patients was associated with swollen joint count (SJC), painful joint count (PJC), and disease activity score 28 (DAS28). ROC curve analysis suggested that the combination of hsa-circ0000175 and hsa-circ0044235 has some value in the diagnosis of new-onset RA from HC, patients with SLE and patients with OA + UA. The logistic regression analysis revealed that the expression of hsa-circ0000175 and hsa-circ0044235 in plasma were risk factors for RA. This study suggests that the combination of plasma hsa-circ0000175 and hsa-circ0044235 improves the diagnostic accuracy for new-onset RA. Moreover, the expression levels of plasma hsa-circ0000175 and hsa-circ0044235 were associated with disease activity and severity of RA. the expression of plasma hsa-circ0044235 new-onset RA patients was associated with swollen joint count (SJC), painful joint count (PJC), and disease activity score 28 (DAS28). ROC curve analysis suggested that the combination of hsa-circ0000175 and hsa-circ0044235 has some value in the diagnosis of new-onset RA from HC, patients with SLE and patients with OA + UA. The logistic regression analysis revealed that the expression of hsa-circ0000175 and hsa-circ0044235 in plasma were risk factors for RA. Yes We confirmed that hsa-circ0000175 was significantly elevated in plasma from patients with new-onset RA compared with HC and patients with new-onset SLE, but significantly was reduced when compared with OA + UA patients. 34008433 SNHG15 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-506-5p) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining//Transwell Assay In the present study, we found that SNHG15 was up-regulated in GC tissues and cell lines. More importantly, microRNA-506-5p (miR-506-5p) was predicted as a direct target of SNHG15 by binding its 3'-UTR and further verified using luciferase reporter assay. Meanwhile, the results of rescue experiments revealed that knockdown of miR-506-5p expression reversed the functional effects of SNHG15 silenced cell proliferation, migration, invasion and apoptosis. Yes Silencing SNHG15 suppressed proliferation migration, invasion and promoted apoptosis of AGS cells. 33899079 SNHG15 LncRNA Homo sapiens Breast Neoplasms BC cells and clinical tissues Interaction(miR-451/c-Myc signaling ) IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our data indicated LncRNA SNHG15 upregulated c-Myc to facilitate BC progression by sponging miR-451 in a competing endogenous RNA (ceRNA)-dependent manner in vitro and in vivo. Specifically, LncRNA SNHG15 and c-Myc were upregulated, while miR-451 was downregulated in BC cells and clinical tissues, compared to their normal counterparts. Yes Our data indicated LncRNA SNHG15 upregulated c-Myc to facilitate BC progression by sponging miR-451 in a competing endogenous RNA (ceRNA)-dependent manner in vitro and in vivo. 33952250 SNHG15 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay Results of qRT-PCR showed that the expression of SNHG15 in cancer tissues was increased compared with that in para-carcinoma tissues. Yes Results of cell counting kit-8 (CCK-8) assay showed that knocking down SNHG15 could significantly inhibit the proliferation of lung cancer A549 cells. 29771418 SNHG16 LncRNA Homo sapiens Rhinitis, Allergic AR tissues Interaction(miR-106b-5p/LIF JAK1/STAT3 pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//ELISA//IF RT-qPCR results showed that the expression of SNHG16 in AR was up-regulated. In conclusion, SNHG16 up-regulates LIF expression by binding with miR-106b-5p, thus promoting the activity of JAK1/STAT3 pathway, and promoting the development of AR. These results provide new targets for the treatment of AR and may help reduce the damage caused by AR. Yes The results showed that SNHG16 promoted cell apoptosis and inflammation. 34407675 SNHG16 LncRNA Homo sapiens Melanoma melanoma tissues and cell lines interaction[sponging miR-132] CCK8//qRT-PCR//Transwell Assay SNHG16 was overexpressed, and miR-132 was low expressed in melanoma tissues and cell lines.SNHG16 promotes the expression of LAPTM4B by sponging miR-132, thereby acting as an oncogene in melanoma. Moreover, overexpression of SNHG16 was associated with poor prognosis of melanoma patients. Yes Knockdown of SNHG16 or overexpression of miR-132 inhibited SK-MEL-2 cell proliferation and migration. 32864914 SNHG16 LncRNA Homo sapiens pancreatic adenocarcinoma PC tissues and cell lines Interaction(miR-302b-3p/SLC2A4 axis) qRT-PCR//Luciferase Report Assay//Western Blot SNHG16 expression was significantly elevated in PC tissues and cell lines and was associated with poor prognosis of PC patients.Knockdown of SNHG16 reduced PC cell proliferation, migration and invasion. SNHG16 acted as a sponge to regulate miR-302b-3p expression in PC cells. In addition, miR-302b-3p targeted SLC2A4 directly. SNHG16 expression was significantly elevated in PC tissues and cell lines and was associated with poor prognosis of PC patients. Yes Knockdown of SNHG16 reduced PC cell proliferation, migration and invasion. SNHG16 acted as a sponge to regulate miR-302b-3p expression in PC cells. In addition, miR-302b-3p targeted SLC2A4 directly. 33435953 SNHG16 LncRNA Homo sapiens Esophageal Neoplasms CSCs Interaction(microRNA-802/PTCH1 Axis) qRT-PCR//MeRIP//RIP Upregulated SNHG16 expression was found in CSCs, whose expression was decreased during the differentiation of CSCs. SNHG16 or PTCH1 overexpression or miR-802 inhibition promoted the proliferation, colony formation, and tumorsphere formation of EC9706 and KYSE150 cells as well as SOX2, OCT4, Bmi-1, and PTCH1 expression. Moreover, SNHG16 and PTCH1 were competitively bound to miR-802, and SNHG16 orchestrated the miR-802/PTCH1 axis to activate the Hedgehog pathway. Yes SNHG16 or PTCH1 overexpression or miR-802 inhibition promoted the proliferation, colony formation, and tumorsphere formation of EC9706 and KYSE150 cells as well as SOX2, OCT4, Bmi-1, and PTCH1 expression. Consistently, SNHG16 knockdown or miR-802 overexpression inhibited EC progression. SNHG16 silencing repressed the tumorigenicity of EC9706 in nude mice. 35579168 SNHG16 LncRNA Homo sapiens Endometrial Neoplasms ECa tissue and cells Regulation[TFAP2A/SNHG16/miR-490-3p/HK2 axis] Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//ChIP Results presented that SNHG16 expression was increased in the ECa tissue and cells, In conclusion, this finding illustrates the vital role of SNHG16 via the TFAP2A/SNHG16/miR-490-3p/HK2 axis in the ECa proliferation and glycolysis, providing an interesting insight for the ECa tumorigenesis. Results presented that SNHG16 expression was increased in the ECa tissue and cells, and the ectopic SNHG16 overexpression was closely correlated with the poor survival rate and recurrence free survival of ECa. Yes In functional experiments, SNHG16 knockdown suppressed the proliferation, glycolysis and tumor growth of ECa cells. 31814916 SNHG16 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Interaction[sponges miR-98-5p] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The ectopic expression of SNHG16 was found in osteosarcoma tissues and cell lines.LncRNA SNHG16 regulated cellular processes in osteosarcoma by sponging miR-98-5p, and SNHG16 may be a new and effective molecular therapeutic target for osteosarcoma. The ectopic expression of SNHG16 was found in osteosarcoma tissues and cell lines, which indicated poor prognosis and lower overall survival rate of osteosarcoma patients. Yes Knockdown of SNHG16 inhibited cell proliferation, migration, invasion, cell cycle and promoted apoptosis in osteosarcoma. 30923843 SNHG16 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction[Sponging miRNA-340 ] Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay We found that SNHG16 is overexpressed in OS tissues and cell lines.The results showed that SNHG16 involves in the migration and invasion of OS cells through sponging miRNA-340. Yes Inhibition of SNHG16 reduced OS cells proliferation, stimulated apoptosis, and decreased migration and invasion. 30726150 SNHG16 LncRNA Homo sapiens Osteosarcoma OS tissues Regulation[miR-1301/BCL9 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In the current study, we confirmed that SNHG16 expression was markedly up-regulated in OS tissues compared to paracancerous tissues.SNHG16 promotes BCL9 expression by sponging miR-1301 to facilitate the proliferation, migration and invasion of OS cells. The elevated level of SNHG16 closely associated with advanced tumor stages, larger tumor size and more distance metastasis. Furthermore, OS patients with high SNHG16 level had a significant poorer overall survival compared to patients with low SNHG16 level. Yes Knockdown of SNHG16 suppressed the proliferation, migration and invasion of U2OS and MG63 cells. 30909141 SNHG16 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Expression[highly expressed] qRT-PCR Small nucleolar RNA host gene 16 (SNHG16) and autophagy-related 4B (ATG4B) were significantly upregulated in osteosarcoma tissues than the normal ones, and the higher expression level of SNHG16 predicted a poor prognosis in osteosarcoma patients. Small nucleolar RNA host gene 16 (SNHG16) and autophagy-related 4B (ATG4B) were significantly upregulated in osteosarcoma tissues than the normal ones, and the higher expression level of SNHG16 predicted a poor prognosis in osteosarcoma patients. Yes SNHG16 was shown to promote cell growth, migration, and invasion, while miR-16 reversed this impact. 31427084 SNHG16 LncRNA Homo sapiens Osteosarcoma tissues of patients with OS and OS cell lines Interaction(miR-1285-3p) qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Western Blot The present study demonstrated that SNHG16 is highly expressed in both the tissues of patients with OS, as well as OS cell lines, and its expression level was positively correlated with clinical stage and poor overall survival.In addition, the present study revealed that microRNA-1285-3p expression levels can be decreased by SNHG16 acting as a 'sponge', and that this pathway takes part in OS tumor growth in vivo, and OS cell proliferation, invasion, migration and apoptosis in vitro. its expression level was positively correlated with clinical stage and poor overall survival Yes Functional assays revealed that the depletion of SNHG16 inhibits OS growth, OS cell progression and promotes apoptosis both in vivo and in vitro. 33823834 SNHG16 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Interaction( miR-488/ ITGA6) CCK8//qRT-PCR SNHG16 and ITGA6 were significantly increased while miR-488 was decreased in osteosarcoma. ITGA6 was screened as a target gene of miR-488, and SNHG16 was sponged by miR-488 in osteosarcoma cells. Yes MiR-488 overexpression and SNHG16 knockdown suppressed migration, invasion and EMT of osteosarcoma cells. Moreover, rescue assays proved that the influences of SNHG16 on osteosarcoma cells migration, invasion and EMT were dependent on miR-488 and ITGA6. In addition, the promotive effects of SNHG16 on osteosarcoma tumor growth and metastasis were further supported by xenograft tumor growth assay. 33598394 SNHG16 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML patients and cells Interaction(PTEN/PI3K/AKT axis) qRT-PCR//Bioinformatics Analysis This study showed that SNHG16 was upregulated in AML patients and cells. Taken together, the present study indicated that SNHG16 promoted proliferation and migration of AML cells via PTEN/PI3K/AKT axis through suppressing CELF2 protein. Yes And SNHG16 overexpression remarkably enhanced the proliferation and migration capacities of HL60 and AML-193 cells, while SNHG16 knockdown acted the opposite way. 33576342 SNHG16 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Interaction[recruiting transcriptional factor SPI1 to upregulate PARP9] RIP//Luciferase Report Assay//ChIP Here, quantitative analysis of SNHG16 and PARP9 expression levels in cervical cancer tissues and cell lines indicated that both SNHG16 and PARP9 were highly expressed compared with controls. These data indicate that SNHG16 recruits SPI1 to upregulate PARP9, which promotes the tumorigenicity of cervical cancer cells. The regulation of their expression might provide a new direction for treating cervical cancer. Yes After ectopic expression and knockdown experiments were conducted, it was observed that silencing SNHG16 inhibited PARP9 expression, proliferation, and invasion of cervical cancer cells, which was rescued by co-transfection of SNHG16 silencing and PARP9 overexpression. Moreover, in vivo experimental results showed that silencing SNHG16 reduced the expression of PARP9 and suppressed tumor growth. 31774223 SNHG16 LncRNA Homo sapiens Prostatic Neoplasms PCa tissue Interaction(miR‑373‑3p/ TGF‑β‑R2/SMAD pathway ) Luciferase Report Assay The results demonstrated that the expression levels of SNHG16 and TGF‑β‑R2 were significantly upregulated in PCa tissues, whereas miR‑373‑3p expression was significantly downregulated (P<0.001). In addition, negative correlations were observed between SNHG16 and miR‑373‑3p (rho, ‑0.631) and miR‑373‑3p and TGF‑β‑R2 (rho, ‑0.516). Yes Overexpression of SNHG16 significantly promoted the proliferation, migration and invasion of PCa cells (P<0.05), and significantly increased the protein expression levels of TGF‑β‑R2, phosphorylated (p)‑SMAD2, p‑SMAD3, c‑Myc and E2F4 (P<0.001). 34643247 SNHG16 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction[Suppressing p21] CCK8//qRT-PCR//Flow Cytometry The expression of SNHG16 were up-regulated in both glioma tissues and cell lines.Moreover, p21 could mediate cell proliferation and monoclonal formation, promote cell apoptosis in glioma, which was negatively correlated with lncRNA SNHG16. The molecule mechanism experiments revealed that SNHG16 could not only inhibit the expression of p21 but also suppressed the level of caspase 3 and 9, while promoted cyclinD1 and cyclinB1 expression. lncRNA SNHG16 could promote the cell proliferation and inhibit the apoptosis of glioma through suppressing p21, indicating that lncRNA SNHG16 might be quite vital for the diagnosis and progression of glioma and could even be a novel therapeutic target for glioma. Yes Knockdown of SNHG16 was associated with poor proliferation, decreased monoclonal formation rates, but increased apoptosis rates, which also caused the high expression of p21. 30972632 SNHG16 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction( SNHG16-miR-4518-PRMT5 ) Western Blot//qRT-PCR//MTT//Luciferase Report Assay//ELISA//Bioinformatics Analysis SNHG16 was highly expressed in glioma tissues and cell lines, which was related to poorer clinicopathologic features and shorter survival time. Further investigation revealed that SNHG16 could up-regulate the expression of miR-4518 targeted gene PRMT5 via acting as an endogenous sponge of miR-4518. Moreover, SNHG16 also affects the expression of Bcl-2 family proteins and the activation of PI3K/Akt signaling pathway. SNHG16 was highly expressed in glioma tissues and cell lines, which was related to poorer clinicopathologic features and shorter survival time. Yes Knockdown of SNHG16 inhibits the viability and induces apoptosis of glioma cells. 29529599 SNHG16 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction(miR-520a-3p/MAPK1 axis) In Vivo Experiment//IHC//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay SNHG16 was overexpressed in NPC tissues and cells. Additionally, SNHG16 could directly bind to miR-520a-3p, thus positively regulating MAPK1 expression. Moreover, functional analysis indicated that miR-520a-3p exerted a tumor-suppressing role in NPC progression. High SNHG16 expression indicated a poor prognosis. Yes SNHG16 knockdown could cause significant inhibition on cell proliferation and metastasis, induce cell apoptosis in NPC cells, and repressed tumor growth and metastasis in vivo. 34045897 SNHG16 LncRNA Homo sapiens Multiple Myeloma MM tissues interaction[sponging miR-342-3p] Flow Cytometry//qRT-PCR//Luciferase Report Assay SNHG16 expression was up-regulated in MM tissues. Knockdown of lncRNA SNHG16 suppresses MM cell proliferation by sponging miR-342-3p, implicating SNHG16 as a novel therapeutic target for MM. Yes SNHG16 knockdown suppressed cell proliferation, arrested cell cycle transition from G1 to S phase, and promoted the apoptosis of MM cells. 32025219 SNHG16 LncRNA Homo sapiens Pancreatic Neoplasms cell lines Regulation[miR-195/SREBP2 axis] Wound Healing Assay//Transwell Assay LncRNA SNHG16 directly sponged miR-195 to modulate the lipogenesis via regulating the expression of SREBP2. Yes Both the knock down of lncRNA SNHG16 and SREBP2 and overexpression of miR-195 suppressed the proliferation, migration, invasion and lipogenesis in pancreatic cancer cells. 31664866 SNHG16 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues Interaction[targeting miR-218-5p] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//cell invasion assay An increase in expression of SNHG16 in PC samples against adjacent normal tissues was shown here.Mechanistically, SNHG16 might serve as a sponge competitive endogenous RNA (ceRNA) for miR-218-5p, thereby playing a role in regulating the expression of high mobility group box 1 (HMGB1) expression, a known direct miR-218-5p target in PC cells. These results provide novel insight into PC tumorigenesis and suggest that SNHG16 could serve as a likely therapeutic intervention in PC. Increased SNHG16 was linked intimately to the tumor-node-metastasis (TNM) stage, distant metastasis, tumor differentiation, and poor overall survival. Yes Loss-of-function experiments revealed that SNHG16 knockdown suppressed the proliferation, formation of colonies, ability to migrate and invade in vitro, along with a lowered growth of the tumor in a mouse model. 30981105 SNHG16 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and CCA cell lines. Interaction( miR-146a-5p/GATA6 Axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay SNHG16 was significantly elevated in CCA tissues from TCGA database and CCA cell lines. miR-146a-5p, a downstream target of SNHG16, was shown to be an intermediate mediator of GATA6 expression regulated by SNHG16. In addition, either the miR-146a-5p inhibitor or overexpression of GATA6 obviously impaired the regulatory effects of SNHG16 downregulation in RBE and HuCCT1 cells. Yes Moreover, downregulation of SNHG16 restricted cell proliferation and increased apoptotic rate of RBE and HuCCT1 cells. 33797690 SNHG16 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cells regulation[miR-877-5p/FOXP4 Axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay SNHG16 expression was increased in LSCC tissues and cells.LncRNA SNHG16 promotes the progression of LSCC by sponging miR-877-5p and upregulating FOXP4. The abnormal expression of SNHG16 was associated with clinical stage and lymph node metastasis in LSCC patients. Yes In addition, knockdown of SNHG16 restrained cell proliferation, migration and invasion in LSCC. 32547087 SNHG17 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Expression(highly expressed) qRT-PCR Utilizing publicly available TCGA-LIHC, GSE102079 HCC datasets, and qRT-PCR, we found SNHG17 was significantly upregulated in HCC tissues and cell lines and was notably associated with larger tumor size, poorly differentiation, presence of vascular invasion, and advanced TNM stage. . Moreover, HCC patients with higher SNHG17 expression had a relatively poor overall survival and disease-free survival, and ERH and PDK4 also played a marked role in the prognosis of HCC. tilizing publicly available TCGA-LIHC, GSE102079 HCC datasets, and qRT-PCR, we found SNHG17 was significantly upregulated in HCC tissues and cell lines and was notably associated with larger tumor size, poorly differentiation, presence of vascular invasion, and advanced TNM stage. Yes Furthermore, gain- and loss-of-function studies demonstrated that SNHG17 promoted cell proliferation and migration and inhibited apoptosis of HCC. 34557456 SNHG17 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC human samples Interaction(miR-3180-3p/RFX1) CCK8//qRT-PCR//Western Blot Our study demonstrated that SNHG17 was upregulated in HCC human samples and involved cell proliferation, migration, invasion progress. Furthermore, we investigated the downstream factor of SNHG17, SNHG17 acted as a molecular sponge for miR-3180-3p, and SNHG17 regulated RFX1 expression via miR-3180-3p. SNHG17 promotes tumor-like behavior in HCC cells via miR-3180-3p/RFX1. Yes Our study demonstrated that SNHG17 was upregulated in HCC human samples and involved cell proliferation, migration, invasion progress. SNHG17 promoted HCC cell growth and metastasis in vivo. 33519911 SNHG1 LncRNA Homo sapiens Nasopharyngeal carcinoma nasopharyngeal carcinoma tissues,cell lines Interaction[miR-145a-5p] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay SNHG1 is highly expressed in nasopharyngeal carcinoma tissues and in cell lines. Down-regulation of SNHG1 facilitated the expression of miR-145-5p and further suppressed the level of NAUK1 in CNE and HNE-1 cells. Silencing of SNHG1, up-regulation of miR-145-5p and inhibition of NAUK1 by relative transfection all attenuated the aggressiveness of CNE and HNE-1 cells both in vivo and in vitro. Moreover, the impaired cell migration and invasion by SNHG1 siRNA could be rescued by cotransfection of miR-145-5p in CNE and HNE-1 cells. LncRNA SNHG1 promoted the expression of NUAK1 by down-regulating miR-145-5p and thus promoted the aggressiveness of nasopharyngeal carcinoma cells through AKT signalling pathway and induced epithelial-mesenchymal transition (EMT). Yes Down-regulation of SNHG1 facilitated the expression of miR-145-5p and further suppressed the level of NAUK1 in CNE and HNE-1 cells. Silencing of SNHG1, up-regulation of miR-145-5p and inhibition of NAUK1 by relative transfection all attenuated the aggressiveness of CNE and HNE-1 cells both in vivo and in vitro. 29575772 SNHG22 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cells regulation[miR-429/SESN3 axis] CCK8//qRT-PCR//Colony Formation Assay//Flow Cytometry Then, we found that SNHG22 was highly expressed in ESCC cells (Kyse-150, TE-10, and Eca109), especially in TE-10 and Eca109. SNHG22 promotes the progression of ESCC by the miR-429/SESN3 axis. Yes Inhibition of SNHG22 was found that can inhibit the progression and promotes autophagy and apoptosis of ESCC cells. 32953807 circFNDC3B CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell line Interaction(miR-214-3p/CDC25A axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay CircFNDC3B was highly expressed in ESCC, and high circFNDC3B expression was tightly associated with poor prognosis in ESCC patients. Mechanistically, circFNDC3B acted as a sponge for miR-214-3p to up-regulate the expression of its target CDC25A. Rescue experiments showed that miR-214-3p inhibitor reversed the anticancer effects of circFNDC3B knockdown. Moreover, forced expression of miR-214-3p suppressed the malignant phenotypes mentioned above, while this condition was abolished by CDC25A overexpression. CircFNDC3B was highly expressed in ESCC, and high circFNDC3B expression was tightly associated with poor prognosis in ESCC patients. Yes Functionally, circFNDC3B knockdown not only suppressed ESCC cell growth, migration and invasion in vitro, but hindered ESCC tumour growth in vivo. 36184488 SNHG29 LncRNA Homo sapiens Spontaneous Preterm Birth HTR8/SVneo cells Regulation(p53/p21 signaling ) Cell Proliferation Assay//qPCR//Western Blot SNHG29 was overexpressed in the placentas of women who delivered preterm with labor and in HTR8/SVneo cells treated with H2O2 (p < 0.05). We observed an increase in the expression of IL-8 and TNF-α in senescent HTR8/SVneo cells (p < 0.05). Yes The levels of mRNA of p53 and p21, protein levels of p53, phospho-p53, p21and phospho-p21, and β-galactosidase activity was decreased in HTR8/SVneo cells depleted of SNHG29, while the opposite trend was observed in HTR8/SVneo cells overexpressing SNHG29 (p < 0.05). 33080448 SNHG26 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and cells Interaction( PGK1/Akt/mTOR signal pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Co-IP//qRT-PCR//FISH//RIP//RNA-seq//Cell Proliferation Assay//Cell Cycle Assay//IHC//Invasion Assay//Transwell Assay The results of next-generation transcriptomic sequencing revealed that lncRNA-SNHG26 was differentially expressed and was associated with TSCC cisplatin resistance. Furthermore, in TSCC cells, SNHG26 was found to bind directly to the PGK1 protein, inhibiting its ubiquitination and activating the Akt/mTOR signaling pathway. The Cancer Genome Atlas dataset and tumor tissue analysis revealed that high SHNG26 expression was associated with the occurrence, progression, and poor prognosis of TSCC. Yes Evidence from cell and animal experiments showed that SNHG26 expression was positively correlated with TSCC proliferation, epithelial-mesenchymal transformation, migration, invasion, and cisplatin resistance. 35118193 SNHG25 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial 30 ovarian cancer tissue samples and 30 normal ovarian tissue samples Expression [highly expressed] qRT-PCR//RNA-seq n the present study, we showed that SNHG25 expression was up-regulated in EOC tissues relative to normal ovarian tissues. High-throughput sequencing and western blot analysis showed a significant decrease in the expression of COMP mRNA and protein in SNHG25 knockdown compared to control ovarian cancer cells. Yes In vitro, functional experiments demonstrated that high expression of SNHG25 promoted proliferation, migration and invasion, and decreased apoptosis, in ovarian cancer cell lines. In vivo, downregulation of SNHG25 inhibited the growth (tumor volume) of subcutaneous xenografts in nude mice.  33613753 SNHG25 LncRNA Homo sapiens Glioma glioma cells and tissues Interaction(miR-579-5p/MAP2K2 ) In Vivo Experiment//IHC//Western Blot//Transfection//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining In this study, we found that SNHG25 was upregulated in glioma cells and tissues. Further studies indicated that SNHG25 positively regulated MAP2K2 through sponging miR-579-5p. High expression of SNHG25 activated MAPK signaling through MAP2K2. These data suggest that SNHG25 is a potential target and biomarker for glioma. Yes CCK-8, EDU, and colony formation assays demonstrated that SNHG25 knockdown markedly inhibited glioma cell proliferation. In vivo studies showed that SNHG25 knockdown significantly inhibited tumor growth. 36071306 SNHG22 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[microRNA-361-3p/HMGA1/Wnt/β-Catenin Axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down SNHG22 and HMGA1 were highly expressed but miR-361-3p was poorly expressed in GC tissues.Collectively, SNHG22 silencing possessed tumor-suppressing potentials in GC development via Wnt/β-catenin pathway by binding to miR-361-3p and downregulating HMGA1, highlighting a new promising road for GC treatment development. Yes Following SNHG22 or HMGA1 silencing or miR-361-3p upregulation, we observed a decline of proliferation, migration, and invasion of GC cells and HUVEC angiogenesis but acceleration of GC cell apoptosis and cell cycle arrest. 33364835 SNHG22 LncRNA Homo sapiens Stomach Neoplasms GC (Gastric Cancer) tissues and cells Interaction(miR-200c-3p/Notch1 axis) In Vivo Experiment//RNA Pull-Down//IHC//ChIP//Western Blot//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Here, we report that the expression of lncRNA SNHG22 (small nucleolar RNA host gene 22) was significantly increased in GC (Gastric Cancer) tissues and cells, which confers poor prognosis of patients. In addition, using RNA pull-down followed MS assay, we found that SNHG22 directly bound to EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) to suppress the expression of tumor suppressor genes. At the same time, SNHG22 sponged miR-200c-3p to increase Notch1 (notch receptor 1) expression. Here, we report that the expression of lncRNA SNHG22 (small nucleolar RNA host gene 22) was significantly increased in GC (Gastric Cancer) tissues and cells, which confers poor prognosis of patients. Yes Knockdown of SNHG22 inhibited the proliferation and invasion ability of GC cells. Moreover, we identified that the transcriptional factor, ELK4 (ETS transcription factor ELK4), could promote SNHG22 expression in GC cells. 34663788 SNHG22 LncRNA Homo sapiens Stomach Neoplasms GC tissue, TCGA database, GC cell lines, and clinical tissue samples Interaction(miR-101-3p/e2f2 axis) CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our result showed that SNHG22 was upregulated significantly in GC tissue samples from TCGA database, GC cell lines, and clinical tissue samples, and its expression was related to low survival rate of gastric cancer patients. Bioinformatics prediction predicted miR-101-3p as the potential target of SNHG22 and E2F2 genes as miR-101-3p target mRNA. We found that E2F2 expression was negatively associated with overall survival of GC patients. Functional study showed that silencing SNHG22 markedly inhibited the proliferation, migration, and invasion of GC cells as well as in vivo tumor growth. This was reversed after inhibiting miR-101-3p or overexpressing E2F2. The lncRNA SNHG22 promotes the proliferation, migration, and invasion of GC cells via the miR-101-3p/E2F2 axis. SNHG22 might be a potential prognostic indicator in gastric cancer. Our result showed that SNHG22 was upregulated significantly in GC tissue samples from TCGA database, GC cell lines, and clinical tissue samples, and its expression was related to low survival rate of gastric cancer patients. Bioinformatics prediction predicted miR-101-3p as the potential target of SNHG22 and E2F2 genes as miR-101-3p target mRNA. We found that E2F2 expression was negatively associated with overall survival of GC patients. Yes Functional study showed that silencing SNHG22 markedly inhibited the proliferation, migration, and invasion of GC cells as well as in vivo tumor growth. 36281526 SNHG22 LncRNA Homo sapiens Colorectal Neoplasms adenoma tissues and ANTs Interaction(miR‑128‑3p/E2F3 ) CCK8//qRT-PCR//Western Blot The present study revealed that SNHG22 expression was most highly expressed in TTs followed by adenoma tissues and ANTs. The mechanistic study revealed that SNHG22 bound to miR‑128‑3p and attenuated its inhibitory effects on E2F transcription factor 3 (E2F3) expression levels and activity. In addition, high SNHG22 expression levels were significantly associated with advanced clinicopathological factors and worse survival in patients with CRC. Yes SNHG22 knockdown markedly inhibited CRC cell proliferation, apoptosis resistance, migration and invasion in vitro, and hindered tumor growth in vivo. 34368861 Snhg3 LncRNA Mus musculus Cerebral Ischaemia/Reperfusion Injury cell models (treated with OGD/R or LPS) and mouse models (tMCAO) Interaction(HDAC3) RNA Pull-Down//Western Blot//Transfection//Co-IP//qRT-PCR//RIP//H&E Staining//ELISA//IHC//IF Levels of SNHG3, microglial activation marker Iba-1, proinflammatory factors (TNF-α and IL-6) were highly expressed in cell models (treated with OGD/R or LPS) and mouse models (tMCAO). Besides, SNHG3 could bind to HDAC3 and promote its expression. Through further study, we found that SNHG3 could stabilize the protein levels of HDAC3 and inhibit the ubiquitination of HDAC3. Furthermore, interference with SNHG3 down-regulated the levels of HDAC3, Iba-1, TNF-α, and IL-6, whereas the overexpression of HDAC3 reversed the results. Yes The H&E staining assay demonstrated that the condition of vacuoles of different sizes, uneven cytoplasmic staining, and inflammatory infiltration in the brain tissue was improved by interference with SNHG3. The immunohistochemistry result showed that microglial activation marker Iba-1 was increased in the shRNA-SNHG3 group, indicating that interference with SNHG3 inhibited the activation of microglia in the brain. 34411323 SNHG22 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(EZH2/DNMT1/miR-16-5p axis) Western Blot//CCK8//qRT-PCR//RIP//ChIP In our report, we discovered the high level of SNHG22 in HCC tissues and cells, and the high expression of SNHG22 was correlated with unfavorable clinical outcome in HCC patients. Mechanistic exploration revealed that SNHG22 recruited DNMT1 to miR-16-5p DNA promoter through EZH2 and inhibited miR-16-5p transcription via DNA methylation. Finally, we verified that the suppression of miR-16-5p countervailed the suppressive effect of SNHG22 deficiency on HCC cell proliferation, migration, invasion, and angiogenesis. Yes Functional assays implied that SNHG22 deficiency suppressed cell proliferation, migration, invasion, and angiogenesis in vitro. Additionally, it was also confirmed that silenced SNHG22 suppressed tumor growth and angiogenesis in vivo. 34652260 SNHG22 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells regulation[miR-324-3p,SUDS3] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP SNHG22 represented a high expression level in TNBC tissues and cells. LncRNA SNHG22 facilitated cell growth and motility in TNBC via sponging miR-324-3p and upregulating SUDS3, highlighting a new promising road for TNBC treatment development. Yes Besides, SNHG22 silencing restrained the proliferation, migration and invasion of TNBC cells. 32565736 hsa_circ_0000745 CircRNA Homo sapiens Precursor Cell Lymphoblastic Leukemia-Lymphoma ALL patients and cell lines Interaction(miR-494-3p/NET1 axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay Circ_0000745 expression was elevated in ALL patients and cell lines. Circ_0000745 acted as a molecular sponge for miR-494-3p in ALL cells. miR-494-3p silencing partly diminished circ_0000745 knockdown-induced anti-tumor effects in ALL cells. NET1 was a target of miR-494-3p, and miR-494-3p overexpression-induced anti-tumor influences were partly counteracted by the accumulation of NET1 in ALL cells. Circ_0000745 can positively regulate NET1 expression by sponging miR-494-3p in ALL cells. Yes Circ_0000745 knockdown restrained cell cycle progression and glycolysis and triggered cell apoptosis and ferroptosis. 34957935 SNHG214 LncRNA Homo sapiens Osteoarthritis knee cartilage regulation[miR-214-5p/PPARGC1B axis] qRT-PCR//ELISA//Luciferase Report Assay//Western Blot The results showed that SNHG7 was distinctly downregulated, while miR-214-5p was significantly upregulated in OA patients and primary chondrocytes treated with IL-1β. Collectively, The above results confirmed that SNHG7 prevents IL-1β induced OA by inhibiting NLRP3 inflammasome and apoptosis through miR-214-5p/PPARGC1B axis. Yes In addition, SNHG7 enhanced cell viability, inhibited apoptosis and inflammation of IL-1β-mediated chondrocytes. 33296783 SNHG20 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Regulation[SNHG20/miR-495-3p/ZFX axis ] qRT-PCR Here, our results showed that the lncRNA SNHG20 expression was significantly higher in GC tissues compared with adjacent normal tissues by quantitative real-time PCR (qRT-PCR) analysis.Furthermore, lncRNA SNHG20 expression negatively associated with miR-495-3p expression and regulated miR-495-3p expression Higher lncRNA SNHG20 expression was highly associated with tumor size and lymphatic metastasis of patients. Patients with higher lncRNA SNHG20 expression predicted a short disease-free survival (DFS) and overall survival (OS). Yes Function assays confirmed that lncRNA SNHG20 knockExpression[down-expression] using RNA interference sExpression[Expression[up-expression]-expression]pressed cell proliferation and invasion of GC by negatively regulating miR-495-3p expression. 30520073 SNHG20 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction[sponging miR-154] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Our results showed that SNHG20 was significantly up-regulated in NSCLC tissues and cells. Furthermore, SNHG20 could function as a competing endogenous RNA (ceRNA) to elevate ZEB2 and RUNX2 expression by sponging miR-154. Rescue assays revealed that miR-154 inhibition could reverse the inhibitory effect of SNHG20 silence on proliferation, migration and invasion in NSCLC cells. More importantly, SNHG20 knockdown suppressed tumor growth in NSCLC in vivo through suppressing miR-154 and elevating ZEB2 and RUNX2 expression. In summary, knockdown of lncRNA SNHG20 suppressed proliferation, migration and invasion, and promotes apoptosis through up-regulating ZEB2 and RUNX2 expression by sponging miR-154 in NSCLC, providing a promising therapeutic target for NSCLC patients. Yes Moreover, SNHG20 knockdown suppressed proliferation, migration and invasion, and induced apoptosis in NSCLC cells. 30780105 SNHG20 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cancer tissues and serum regulation[Wnt/β-catenin signaling pathway] qRT-PCR//Luciferase Report Assay//Western Blot LncRNA SNHG20 was highly expressed in the cancer tissues and serum of patients with NSCLC. LncRNA SNHG20 promotes the proliferation and inhibits the apoptosis of NSCLC cells by targeting miR-197 through the Wnt/β-catenin signaling pathway. Yes LncRNA SNHG20 could promote the proliferation and inhibit the apoptosis of NSCLC cells. 31957836 SNHG20 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-495/STAT3 axis] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay//Transwell Assay In the present study, SNHG20 expression was found to be significantly upregulated in CRC tissues and cell lines.Taken together, the results revealed that SNHG20 facilitated CRC progression by regulating STAT3 expression and by sponging miR‑495. Association analysis indicated that high SNHG20 expression was significantly association with greater tumor size (P=0.014), tumor invasion depth (P=0.019), positive lymph node status (P=0.022), distant metastasis (P=0.017) and advanced tumor node metastasis stage (P=0.038). Yes Loss?of?function experiments indicated that SNHG20 knockdown could significantly suppress proliferation, migration and invasion in vitro. Notably, SNHG20 knockdown significantly inhibited tumor growth and lung metastasis in vivo. 33179110 hsa_circ_30032 CircRNA Homo sapiens renal fibrosis BUMPT cells and unilateral ureteral obstruction (UUO)-induced mice Interaction(miRNA-96-5p/HBEGF/KRAS axis) Western Blot//Transfection//qRT-PCR//FISH//Luciferase Report Assay//IHC These results demonstrate that circRNA_30032 promotes renal fibrosis via the miR-96-5p/HBEGF/KRAS axis and suggest that circRNA_30032 is a potential therapeutic target for treatment of renal fibrosis. Yes CircRNA_30032 silencing significantly reduced renal fibrosis in UUO model mice by increasing miR-96-5p levels and decreasing levels of HBEGF and KRAS. 33973871 Snhg3 LncRNA Mus musculus Brain Injuries brain tissue,cell line Expression[lower expressed] CCK8//qRT-PCR//MTT//Western Blot In this study, we determined the role of Snhg3 in the pathogenesis of HIBD. Snhg3 expression was significantly down-regulated in the neonatal brain and primary hippocampal cells response to hypoxic/ischemic stress. Yes Snhg3 overexpression protected against hypoxic/ischemic-induced brain injury in vivo and hippocampal cell injury in vitro. 31751562 SNHG20 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues Expression[highly expressed] CCK8//qRT-PCR//Western Blot SNHG20 expression was markedly higher in serous EOC tissues than that in adjacent tissues and closely correlated with histological grade and lymph node (LN) status. Patients with high SNHG20 showed a shorter overall survival (OS) and SNHG20 was an independent risk factor for the prognosis of serous EOC. Yes . Knockdown of SNHG20 remarkably inhibited EOC cell proliferation, migration, and invasion, which was associated with dysregulation of P21, Cyclin D1, E-cadherin, and Vimentin. 30846486 SNHG3 LncRNA Homo sapiens Prostatic Neoplasms Pca tissues and cells Interaction(microRNA-1827) In Vivo Experiment//Western Blot//Wound Healing Assay//RIP//qRT-PCR//Luciferase Report Assay//Invasion Assay The results demonstrated that SNHG3 expression was upregulated in PCa tissues downloaded from The Cancer Genome Atlas database, which was associated with poor prognosis. Bioinformatic analysis revealed that microRNA (miRNA/miR)-1827 was a downstream target of SNHG3. The direct interaction between SNHG3 and miR-1827 was validated via the dual-luciferase reporter and RNA immunoprecipitation assays. Pearson's correlation analysis demonstrated that SNHG3 expression was negatively correlated with miR-1827 expression at different stages of PCa. The results demonstrated that SNHG3 expression was upregulated in PCa tissues downloaded from The Cancer Genome Atlas database, which was associated with poor prognosis. Yes Furthermore, cell proliferation, migration and invasion were significantly inhibited following SNHG3 knockdown in vitro, the effects of which were reversed following overexpression of SNHG3 in PCa cells. 35814830 SNHG3 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tumors and cell lines regulation[miR-326/ITGA5 axis,Vav2/Rac1 signaling pathway] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that the expression of SNHG3 and ITGA5 was upregulated and miR-326 was downregulated in TNBC tumors and cell lines (MDA-MB-231, BT-549, MDA-MB-468 and SUM159). Silencing of SNHG3 suppressed the malignant development of TNBC cells, at least partially, through miR-326/ITGA5 axis and inhibiting Vav2/Rac1 signaling pathway. Yes Functionally, both SNHG3 silencing and miR-326 overexpression enhanced cell apoptosis, but depressed cell viability, migration and invasion in MDA-MB-231 and BT-549 cells, as well as inhibited Vav2 and Rac1 expression. 32495883 SNHG3 LncRNA Homo sapiens Glioma glioma tissues regulation[miR-384/HDGF axis] CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Transwell Assay The expression of SNHG3 and HDGF was upregulated, whereas miR-384 was downregulated in glioma tissues, compared with the normal tissues. LncRNA SNHG3 promotes cell proliferation, migration, and invasion in glioma by enhancing HDGF expression via miR-384 sponging, representing the promising targets for the development of novel therapeutic strategies. Yes Moreover, SNHG3 or HDGF knockdown significantly suppressed proliferation, migration, and invasion and induced apoptosis in glioma. 33817254 SNHG3 LncRNA Homo sapiens Glioma glioma tissues Interaction(miR-485-5p/LMX1B axis) In Vivo Experiment//qRT-PCR//Transfection//Luciferase Report Assay In addition, the expression of SNHG3 and LMX1B in advanced glioma tissues was significantly upregulated, while the expression of miR-485-5p was significantly downregulated. These results indicate that lncRNA SNHG3 can regulate the expression of LMX1B by sponging miR-485-5p, thereby promoting the proliferation, migration, and invasion of glioma cells. Yes SNHG3 overexpression reduced the expression of miR-485-5p; increased the expression of LMX1B; and promoted the proliferation, migration, and invasion of glioma cells. In addition, subcutaneous and orthotropic xenograft models confirmed that lncRNA SNHG3 silencing or miR-485-5p overexpression significantly reduced the growth of glioma xenografts and prolonged survival time. 34153159 SNHG3 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines Interaction(miR-890) Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//cell invasion assay//Colony Formation Assay The results revealed that SNHG3 expression levels were downregulated in LUAD tissues and cell lines. Mechanistically, microRNA- (miR-) 890 was identified as a potential target of SNHG3, and its expression was negatively regulated by SNHG3. Notably, SNHG3 was found to promote LUAD progression by targeting miR-890. Yes Functionally, SNHG3 overexpression suppressed the proliferation, migration, and invasion of LUAD cells, while promoting apoptosis. 34306585 SNHG3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues and cells Interaction(miR-515-5p/SUMO2 Axis) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay In the present study, SNHG3 was found to be highly expressed in lung cancer tissues and cells. In addition, SNHG3 was found to have the ability to bind to miR-515-5p. Furthermore, Small Ubiquitin Like Modifier 2 (SUMO2) was identified to be the downstream target of miR-515-5p, which was negatively correlated with miR-515-5p expression. SNHG3 could positively regulate SUMO2 expression by sponging miR-515-5p. Yes Downregulation of SNHG3 could inhibit cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process. 34032148 SNHG3 LncRNA Homo sapiens Cholangiocarcinoma CCA cells Interaction(miR-3173-5p/ERG Axis) RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Invasion Assay SNHG3 was significantly upregulated in CCA cells compared with normal human intrahepatic biliary epithelial cells. Mechanistically, SNHG3-sponged miR-3173-5p, thus releasing the repression of ERG by miR-3173-5p. Rescue experiments showed that the miR-3173-5p/ERG axis mediated the oncogenic effect of SNHG3. Yes Knockdown of SNHG3 inhibited the proliferation and migration of CCA cells. 34647226 SNHG3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cells regulation[Wnt/β-catenin pathway,miR-340-5p/YAP1 axis] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot We found that the levels of SNHG3 and YAP1 were increased but the miR-340-5p expression was decreased in LSCC tissues and cells.In conclusion, knockdown of SNHG3 inhibited LSCC progression via inactivating Wnt/β-catenin pathway by regulating the miR-340-5p/YAP1 axis. Yes The knockdown of SNHG3 or YAP1 inhibited cell viability and glycolysis but induced apoptosis in LSCC cells. 32538668 SNHG3 LncRNA Homo sapiens Prostatic Neoplasms cell lines interaction[miR-577 ] RNA Pull-Down//Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this work, SNHG3 exerted high expression in prostate cancer cell lines.All the results above explained that SNHG3 accelerated prostate cancer progression by sponging miR-577 to up-regulate SMURF1 expression, suggesting that SNHG3 may act as a biomarker for prostate cancer patients. Yes Suppression of SNHG3 inhibited cell proliferation, migration, EMT (epithelial-mesenchymal transition) process and promoted cell apoptosis. 32248648 SNHG3 LncRNA Homo sapiens Prostatic Neoplasms PCa tissue and cells Interaction(SNHG3/miR-152-3p/SLC7A11) In Vivo Experiment//IHC//Western Blot//Transfection//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//Colony Formation Assay//Invasion Assay In this study, our analysis in the TCGA database revealed high SNHG3 expression in PCa tissue. It was noted that SNHG3 as a molecular sponge of miR-152-3p stimulated proliferation, migration, and invasion, restrained methionine dependence and apoptosis, and affected the cell cycle of PCa cells via targeting SLC7A11. Additionally, we constructed xenograft tumor models in nude mice and confirmed that knockdown of SNHG3 could restrain PCa tumor growth and elevate methionine dependence in vivo. Yes It was noted that SNHG3 as a molecular sponge of miR-152-3p stimulated proliferation, migration, and invasion, restrained methionine dependence and apoptosis, and affected the cell cycle of PCa cells via targeting SLC7A11. Additionally, we constructed xenograft tumor models in nude mice and confirmed that knockdown of SNHG3 could restrain PCa tumor growth and elevate methionine dependence in vivo. 35123415 SNHG3 LncRNA Homo sapiens Aortic Valve, Calcification of human and mouse calcified aortic valves Regulation(BMP2) In Vivo Experiment SNHG3 upregulation was verified in human and mouse calcified aortic valves. In-depth functional assays showed SNHG3 physically interacted with polycomb repressive complex 2 to suppress the H3K27 trimethylation BMP2 locus, which in turn activated BMP2 expression and signaling pathways. Taken together, SNHG3 promoted aortic valve calcification by upregulating BMP2, which might be a novel therapeutic target in human calcific aortic valve disease. Yes Moreover, in vivo and in vitro studies showed SNHG3 silencing markedly ameliorated aortic valve calcification. 36317131 SNHG3 LncRNA Homo sapiens Prostatic Neoplasms bone metastasis-positive PC tissues Interaction(SNHG3/miR-214-3p/TGF-β axis) Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay Our results indicated that SNHG3 was upregulated in bone metastasis-positive PC tissues compared to bone metastasis-negative PC tissues and adjacent normal tissues. Mechanistically, SNHG3 enhanced the expression of transforming growth factor beta receptor 1 (TGFBR1) and activated transforming growth factor-Beta (TGF-β) signaling by targeting miR-214-3p. High expression of SNHG3 indicates advanced clinicopathological features and predicts poor prognosis in patients with PC. Yes Meanwhile, SNHG3 knockdown suppressed the proliferation, migration, and invasion abilities of PC cells and inhibited PC cell metastasis to the bone. 35030969 SNHG3 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-370-5p/EZH1 axis) CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay SNHG3 was upregulated in CRC tissues and cell lines. The SNHG3/miR-370-5p/EZH1 axis was ascertained. Its high level was correlated to advanced tumor staging, positive lymph node metastasis and poor prognosis of CRC. Yes Knockdown of SNHG3 reduced proliferative and invasive rates of SW480 and HT29 cells. 34661273 SNHG3 LncRNA Homo sapiens Carcinoma, Renal Cell Regulation[ SNHG3/miR-139-5p/TOP2A axis ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay In this study, we analyzed the available public TCGA and GEO databases, and found that the expression of SNHG3 was increased in clear cell renal cell carcinoma (ccRCC), which was positively correlated with many clinicopathological parameters, and the higher expression of SNHG3 predicted worse clinical prognosis. Our work suggested that the SNHG3/miR-139-5p/TOP2A axis plays an important role in the proliferation and metastasis of ccRCC, and was expected to be a new biomarker for diagnosis, prognosis and a target for treatment of ccRCC. In this study, we analyzed the available public TCGA and GEO databases, and found that the expression of SNHG3 was increased in clear cell renal cell carcinoma (ccRCC), which was positively correlated with many clinicopathological parameters, and the higher expression of SNHG3 predicted worse clinical prognosis. Yes Functional experiments indicated that knockdown of SNHG3 could significantly inhibit the proliferation and metastasis of ccRCC in vitro and in vivo. 31505165 SNHG3 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Interaction(microRNA-10b-5p/BIRC5) Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay The two novel lncRNAs (LINC00997, SNHG3) were up-regulated in ccRCC tissues and positively with the BICR5 protein expression. However, Suppressing SNHG3 expression reduced BIRC5 protein expression compared with the LINC00997, most importantly, Suppressing SNHG3 expression suppressed tumor progression in vitro. In addition, SNHG3 promotes the expression of BIRC5 protein by sponging microRNA-10b-5p. Yes However, Suppressing SNHG3 expression reduced BIRC5 protein expression compared with the LINC00997, most importantly, Suppressing SNHG3 expression suppressed tumor progression in vitro. In addition, SNHG3 promotes the expression of BIRC5 protein by sponging microRNA-10b-5p. 35116306 SNHG3 LncRNA Homo sapiens laryngeal carcinoma LC tissues and cell lines Regulation[miR-384/WEE1 axis] qRT-PCR//Luciferase Report Assay Our results showed increased SNHG3 in LC tissues and cell lines.Collectively, our results indicate that SNHG3 regulated LC cell migration and invasion via the miR-384/WEE1 axis. Yes Loss of function of SNHG3 reduced cell viability, migration, and invasion of TU212 and TU686 cells. 31238052 SNHG3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR‑1343‑3p) Western Blot//Bioinformatics Analysis//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining//Transwell Assay The findings indicated that lncRNA SNHG3 was highly expressed in NSCLC tissues and cell lines. Yes Knockdown of lncRNA SNHG3 inhibited cell proliferation, migration and invasion, and accelerated cell apoptosis in NSCLC cell lines. The results of the bioinformatics analysis and the luciferase reporter assay indicated that lncRNA SNHG3 directly bound to miR‑1343‑3p and that it could downregulate the expression levels of miR‑1343‑3p to promote the progression of NSCLC. 34132359 circPTPN14 CircRNA Homo sapiens renal fibrosis renal tubule epithelial cells, mouse kidneys Interaction(FUBP1/FUSE/MYC ) Western Blot//qRT-PCR//Luciferase Report Assay//IHC//IF We found that a circular RNA, circPTPN14, is highly expressed in human kidneys with biopsy-proved chronic interstitial fibrosis, mouse kidneys subjected to ischemia/reperfusion (IR) or unilateral ureteral obstruction (UUO), and TGFβ1-stimulated renal tubule epithelial cells (TECs). The binding of circPTPN14 to the KH3 and KH4 domains of far upstream element (FUSE) binding protein 1 (FUBP1) enhanced the interaction between FUBP1 and FUSE domain, which was required for the initiation of MYC transcription. In human kidneys (n = 30) with biopsy-proved chronic interstitial fibrosis, the expression of circPTPN14 positively correlated with MYC expression. Yes The intrarenal injection of circPTPN14 shRNA alleviated the progression of fibrosis in kidneys subjected to IR or UUO. Knockdown of circPTPN14 in TECs inhibited TGFβ1-induced expression of profibrotic genes, whereas overexpressing circPTPN14 increased the profibrotic effect of TGFβ1. 36394649 circPlekha7 CircRNA Homo sapiens renal fibrosis renal tissues Interaction(miR-493-3p/KLF4) qRT-PCR circPlekha7 was diminished in renal tissues from chronic kidney disease patients and TGF-β1-treated human kidney 2 cells and tubular epithelial cells, while miR-493-3p was upregulated. Overexpression of circPlekha7 or knockdown of miR-493-3p suppressed TGF-β1 induced enhancements on epithelial to mesenchymal transition and fibrogenesis, as well as attenuated renal fibrosis and injury in mice subjected to unilateral ureteral obstruction. Yes Overexpression of circPlekha7 or knockdown of miR-493-3p suppressed TGF-β1 induced enhancements on epithelial to mesenchymal transition and fibrogenesis, as well as attenuated renal fibrosis and injury in mice subjected to unilateral ureteral obstruction. 35172608 hsa_circ_0000745 CircRNA Homo sapiens Precursor Cell Lymphoblastic Leukemia-Lymphoma leukemia cells regulation[ERK pathway] qRT-PCR In this study, we observed circ-0000745 upregulated in leukemia cells (Kasumi-1 and KG-1). Altogether, these results revealed that upregulated circ-0000745 in leukemia cells could promoter cell viability by increasing the activation of ERK pathway. Yes Upregulated the expression of circ-0000745 significantly enhanced the proliferation of Kasumi-1 and KG-1 cells, and reduced the ratio of apoptosis cells. Knock down the endogenous expression of circ-0000745 suppressed the cell proliferation and increased the ratio of apoptosis cells. 32360844 SNHG17 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines (PLC, Hep3B, Huh7 and 7721) Expression [highly expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Cell Viability Assay//Cell Cycle Assay We firstly found that expression levels of lncRNA SNHG17 in HCC tissues and cell lines was higher than that in para-carcinoma tissues and QSG-7701 cells (P<0.05). In addition, we observed that patients with tumor size ≥ 5cm, HCC stages III-IV or poor pathological histological types, lncRNA SNHG17 expression were significantly higher than those with tumor size <5 cm, HCC stages I-II or good histopathological types (P<0.05). Yes  In vitro studies showcased that low expression of lncRNA SNHG17 restrained HCC cell proliferation and evoked cell cycle arrest. Further, silence of lncRNA SNHG17 up-regulated p57 expression in HCC cells. 34921029 rno_circ_0004002 CircRNA Homo sapiens Anorectal Malformations anorectal tissues Interaction[targeting miR-342-5p and Wnt3a] qRT-PCR//RNA-seq Among the downregulated circRNAs, rno_circ_0004002 was selected as the candidate circRNA. Yes Functionally, silencing of rno_circ_0004002 was correlated with suppression of proliferation, and promotion of apoptosis and epithelial-mesenchymal transition (EMT) in anorectal development. 31074015 Snhg20 LncRNA Mus musculus Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-2467-3p/E2F3) Western Blot//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay SNHG20 and E2F3 was upregulation in NSCLC tissues and cell lines. Besides, SNHG20 activated protein kinase B (AKT) signaling pathway and increased E2F3 level in NSCLC cells through targeting miR-2467-3p. Yes Mechanical experiment displayed that knockdown of SNHG20 or E2F3 silencing could inhibit proliferation, motility, and improve apoptosis in NSCLC cell lines. Restored expression of E2F3 could effectively reverse reduction of proliferation, motility, and promotion of apoptosis caused by SNHG20 silencing in NSCLC cells. 32456448 Snhg20 LncRNA Mus musculus Silicosis lung tissues and TGF-β1 treated fibroblasts Interaction(miR-490-3p/TGFBR1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//IF MiR-490-3p was significantly downregulated in silica-induced fibrotic mouse lung tissues and TGF-β1 treated fibroblasts. Moreover, overexpressed miR-490-3p could relieve silica-induced lung fibrosis in vivo, and prevent the process of fibroblast-to-myofibroblast transition(FMT)in vitro. Mechanistically, TGFBR1 was one of the major target genes of miR-490-3p, and tightly associated with the process of fibroblasts activation. SNHG20, as opposed to miR-490-3p expression, was elevated in TGF-β1-treated fibroblast cell lines and contributed to decreased levels of miR-490-3p. Taken together, these data indicated that miR-490-3p plays a key role in silica-induced pulmonary fibrosis. Yes overexpressed miR-490-3p could relieve silica-induced lung fibrosis in vivo, and prevent the process of fibroblast-to-myofibroblast transition(FMT)in vitro. Mechanistically, TGFBR1 was one of the major target genes of miR-490-3p, and tightly associated with the process of fibroblasts activation. 33482250 SNHG18 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC specimens Interaction(miR-211-5p/BRD4 axis) ChIP//Western Blot//Wound Healing Assay//CCK8//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay SNHG18 upregulation in NSCLC specimens correlated with lymph node metastasis and reduced overall survival of NSCLC patients. SNHG18 expression served as an independent prognostic factor for NSCLC. Mechanically, SNHG18 exerted its prometastatic effects on NSCLC cells through repression of miR-211-5p and induction of BRD4. Clinical evidence indicated that SNHG18 expression was negatively correlated with miR-211-5p expression in NSCLC tissues. SNHG18 upregulation in NSCLC specimens correlated with lymph node metastasis and reduced overall survival of NSCLC patients. Yes Knockdown of SNHG18 blocked MKL1-induced growth and invasion of NSCLC cells in vitro. Animal studies validated the requirement for SNHG18 in NSCLC growth and metastasis. Moreover, overexpression of SNHG18 promoted NSCLC cell proliferation and invasion. 33500406 hsa_circ_0056558 LncRNA Homo sapiens Spondylitis, Ankylosing AS tissue Regulation(microRNA-1290) Western Blot//Transfection//Proliferation Assay//qRT-PCR//Cell Apoptosis Assay//PCR//Cell Proliferation Assay//Bioinformatics Analysis//IF Our findings revealed that the expression levels of both circ_0056558 and CDK6 in AS tissue were significantly higher than that in normal samples. Besides, hsa_circ_0056558 could suppress cell proliferation and differentiation by facilitating CDK6 expression and suppressing miR-1290 expression in AS. Over-expression of miR-1290 negatively regulated CDK6 expression to enhance cell proliferation. The protein levels of p-AKT, p-NF-κB p65, and p-IκBα were promoted by hsa_circ_0056558 or CDK6 over-expression while suppressed by miR-1290 up-regulation. In conclusion, our study demonstrated that hsa_circ_0056558 and CDK6 suppressed cell proliferation and differentiation while enhanced cell apoptosis by competitive binding to miR-1290 in AS, which might be possibly achieved by PI3K/AKT/NF-κB pathway, providing us novel therapeutic strategy for AS. Yes Over-expression of miR-1290 negatively regulated CDK6 expression to enhance cell proliferation. The protein levels of p-AKT, p-NF-κB p65, and p-IκBα were promoted by hsa_circ_0056558 or CDK6 over-expression while suppressed by miR-1290 up-regulation. 33685301 hsa_circ_0121582 CircRNA Homo sapiens Leukemia leukemia cells regulation[Wnt/β-catenin signaling] qRT-PCR//RNA Pull-Down//RIP//Western Blot A new and highly stable circRNA was found, which was derived from the reverse splicing of GSK3β exon 1 to exon 7, and hsa_circ_0121582 was down-regulated in leukemia cells. The upregulated GSK3β inhibited the Wnt/β-catenin signaling pathway, and reduced the aggregation of β-catenin in the nucleus, thus inhibited the proliferation of leukemia cells. Yes In gain-of-function experiments, the up-regulated hsa_circ_0121582 inhibited the proliferation of leukemia cells in vitro and in vivo. 32472455 SNHG18 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-338-5p/FOXD1 axis) ChIP//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay It was revealed that, SNHG18 expression in glioma was up-regulated and associated with unfavorable prognosis of the patients; MiR-338-5p was a target of SNHG18, and SNHG18 promoted the expression of FOXD1 by decoying miR-338-5p. Additionally, E2F1 could bind to the promoter of SNHG18 to elevate its expression. In conclusion, SNHG18 accelerates glioma progression via regulating the miR-338-5p/FOXD1 axis. It was revealed that, SNHG18 expression in glioma was up-regulated and associated with unfavorable prognosis of the patients; Yes knockdown of SNHG18 repressed the malignant biological behaviors of glioma cells, enhanced E-cadherin expression and repressed N-cadherin and Vimentin expressions. 34937497 SNHG18 LncRNA Homo sapiens Carcinoma, Hepatocellular HBV-associated HCC cells Expression(lower expressed) Transfection//Migration Assay//qRT-PCR//Cell Proliferation Assay//Invasion Assay Downregulated SNHG18 in HBV-associated HCC was demonstrated to be involved in disease development and predict patients' prognosis. Downregulated SNHG18 in HBV-associated HCC was demonstrated to be involved in disease development and predict patients' prognosis. Yes The downregulation of SNHG18 dramatically promoted cellular processes of HBV-associated HCC could reverse the inhibitory effect of OA. 35221722 SNHG17 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cell lines Interaction[inhibiting P15 and P16] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Analysis of The Cancer Genome Atlas (TCGA) database revealed that SNHG17 expression was remarkably higher in gastric carcinoma tissues than normal stomach mucosae (P=4.85×10-10). We confirmed that SNHG17 was overexpressed in gastric cancer tissues (P<0.0001) and cell lines (P<0.01) compared with corresponding noncancerous tissues and gastric epithelial cell line, respectively. Mechanistically, we found that SNHG17 inhibited P15 and P16, and enhanced CDK4 expression, resulting in a G0/G1 cell cycle arrest, and that SNHG17 inhibited cell apoptosis. Furthermore, SNHG17 levels in tumor tissues were associated with lymph node metastasis (P=0.0006), pTNM stage (P=0.0061), and lymphovascular invasion (P=0.0005), but were not associated with overall survival (OS) (P=0.888). Yes Loss-of-function studies indicated that SNHG17 promoted gastric carcinoma cell proliferation in vitro and in vivo (P<0.01), and that SNHG17 enhanced gastric cancer cell migration (P<0.01). 35116784 SNHG17 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines,blood Interaction[silencing of p15 and p57] qRT-PCR Our results showed that SNHG17 expression was upregulated in GC tissues and cells, and its high expression was significantly correlated with increased invasion depth, lymphatic metastasis, and advanced TNM stage. The expression of plasma SNHG17 was also found upregulated in patients with GC compared with healthy controls, with a moderate accuracy for diagnosis of GC (area under the receiver operating characteristic curve = 0.748; 95% CI, 0.666-0.830). Mechanistic investigations showed that SNHG17 was associated with polycomb repressive complex 2 and that this association was required for epigenetic repression of cyclin-dependent protein kinase inhibitors, including p15 and p57, thus contributing to the regulation of GC cell cycle and proliferation. Furthermore, rescue experiments indicated that SNHG17 functioned as an oncogene via activating enhancer of zeste homolog 2 in GC cells. Our results showed that SNHG17 expression was upregulated in GC tissues and cells, and its high expression was significantly correlated with increased invasion depth, lymphatic metastasis, and advanced TNM stage. Yes Gain- and loss-of-function of SNHG17 revealed that SNHG17 promoted GC cell proliferation, cell cycle progression, invasion, and migration and inhibited apoptosis. 30256413 SNHG20 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines interaction[miR-2467-3p/E2F3] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay SNHG20 and E2F3 was upregulation in NSCLC tissues and cell lines.SNHG20 contributed to NSCLC development through mediating AKT signaling pathway and sponging miR-2467-3p to elevate E2F3 expression in NSCLC cells. Yes Mechanical experiment displayed that knockdown of SNHG20 or E2F3 silencing could inhibit proliferation, motility, and improve apoptosis in NSCLC cell lines. 32456448 SNHG17 LncRNA Homo sapiens Breast Neoplasms BC samples and cell lines interaction[sponging miR-124-3p] Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay An increased SNHG17 was observed in BC samples and cell lines compared with corresponding control.The present study demonstrated that the lncRNASNHG17 could regulate the progression of BC by sponging miR-124-3p. Yes Increased SNHG17 was closely associated with poor prognosis.SNHG17 depletion suppressed cell proliferation, migration and invasion in vitro, as well as inhibited tumor growth in xenograft tumor models. 32042267 SNHG17 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Expression[lower expressed] Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//MTT//EdU Staining In the present study, we analyzed The Cancer Genome Atlas (TCGA) data, and we found that lncRNA Small Nucleolar RNA Host Gene 17 (SNHG17) was upregulated in NSCLC driven by the amplification of copy number, indicating the special role of SNHG17 in NSCLC. Yes Results showed that the knockdown of SNHG17 inhibited the proliferation and migration and promoted the apoptosis of NSCLC cells. 31310946 SNHG17 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Interaction(c-Jun/c-Myc axis ) CCK8//qRT-PCR//Western Blot The present study demonstrated that SNHG17 was upregulated in ESCC tissues and cell lines, induced by TGF-β1, and associated with poor survival. SNHG17 was found to directly regulate c-Myc transcription by binding to c-Jun protein and recruiting the complex to specific sequences of the c-Myc promoter region, thereby increasing its expression. Moreover, SNHG17 hyperactivation induced by TGF-β1 results in PI3K/AKT pathway activation, promoting cells EMT, forming a positive feedback loop. The present study demonstrated that SNHG17 was upregulated in ESCC tissues and cell lines, induced by TGF-β1, and associated with poor survival. Yes It is also involved in the epithelial-to-mesenchymal transition (EMT) process.Furthermore, SNHG17 facilitated ESCC tumor growth in vivo. 34714590 SNHG17 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction(miR-338-3p/SOX4 axis) CCK8//qRT-PCR " Results demonstrated SNHG17 to be markedly upregulated in ESCC.Mechanistic analysis suggested that SNHG17 acts as an endogenous ""sponge"" competing with miR-338-3p to regulate SOX4, thereby promoting tumor progression. " Yes Knockdown of SNHG17 significantly suppressed ESCC cell proliferation, invasion, and epithelial-mesenchymal transition in vitro and tumor growth in vivo. 34429400 circZXDC CircRNA Homo sapiens Moyamoya Disease MMD plasma, VSMC Interaction(circZXDC-miR-125a-3p-ABCC6 axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay The results from a series of in vitro experiments, such as dual luciferase reporter assays, cell transfection, CCK-8 assays, Transwell assays, and Western blotting, indicate a higher level of circZXDC in the MMD plasma, especially in those MMD patients with the RNF213 mutation. CircZXDC sponges miR-125a-3p to increase ABCC6 expression, which induces ERS (endoplasmic reticulum stress), and subsequently regulates VSMC transdifferentiation from the contractive phenotype to the synthetic phenotype, contributing to the intima thickness of MMD vessels. Yes Moreover, circZXDC overexpression results in a VSMC phenotype switching toward a synthetic status, with increased proliferation and migration activity. 36497052 SNHG17 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-339-5p-FOSL2-SNHG17 positive feedback loop) qRT-PCR Using multiple cohorts, we confirmed that SNHG17 is aberrantly upregulated in CRC and correlated with poor survival. SNHG17 impedes PES1 degradation by inhibiting Trim23-mediated ubiquitination of PES1. SNHG17 upregulates FOSL2 by sponging miR-339-5p, and FOSL2 transcription activates SNHG17 expression, uncovering a SNHG17-miR-339-5p-FOSL2-SNHG17 positive feedback loop. Using multiple cohorts, we confirmed that SNHG17 is aberrantly upregulated in CRC and correlated with poor survival. Yes In vitro and in vivo functional assays indicated that SNHG17 facilitates CRC proliferation and metastasis. 34782005 SNHG17 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissue samples and cell lines Interaction(miR-328-3p) Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay Highly expressed SNHG17 was evident in RCC tissue samples and cell lines, and SNHG17 overexpression was related to advanced TNM stage and reduced relapse-free and overall survival of patients with RCC.More importantly, SNHG17 could upregulate the expression of H2AX by acting as a miR-328-3p sponge. In vivo experiments confirmed that SNHG17 promoted the growth of RCC tumors. SNHG17/miR-328-3p/H2AXaxis might be involved in RCC progression, which provided a potential therapeutic target for RCC. Highly expressed SNHG17 was evident in RCC tissue samples and cell lines, and SNHG17 overexpression was related to advanced TNM stage and reduced relapse-free and overall survival of patients with RCC. Yes Knockdown of SNHG17 prohibited malignant phenotypes, whereas ectopic SNHG17 expression showed the opposite effects. 34497156 hsa_circ_0003307 CircRNA Homo sapiens Spondylitis, Ankylosing AS patients Regulation(PI3K/AKT pathway) qRT-PCR//IF//ELISA//Western Blot The expression level of hsa_circ_0003307 was significantly high in AS patients and was positively associated with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and Bath Ankylosing Spondylitis Functional Index (BASFI). We found that hsa_circ_0003307 overexpression could promote the activation of the PI3K/AKT pathway and expression of inflammatory cytokines - tumor necrosis factor alpha (TNF-α) and TNF-α-induced protein 2 (TNFAIP2). However, hsa_circ_0003307 knockdown reduced the expression of TNF-α and TNFAIP2. Yes We found that hsa_circ_0003307 overexpression could promote the activation of the PI3K/AKT pathway and expression of inflammatory cytokines - tumor necrosis factor alpha (TNF-α) and TNF-α-induced protein 2 (TNFAIP2). However, hsa_circ_0003307 knockdown reduced the expression of TNF-α and TNFAIP2. 35275449 SNHG20 LncRNA Homo sapiens Retinoblastoma RB tissues and cell lines Interaction( miR‑335‑5p/E2F3 axis) qRT-PCR//RNA Pull-Down SNHG20 expression was significantly increased in RB tissues and cell lines. Moreover, mechanistic investigations demonstrated that SNHG20 could enhance the expression of E2F3 by sponging of miR‑335‑5p. Yes Silencing of SNHG20 in RB cells was shown to inhibit cell proliferation, clonogenic survival, migration and invasion. 34080033 SNHG20 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells regulation[miR-338-3p/MCL1 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay The levels of SNHG20 and MCL1 were upregulated, while miR-338-3p level was downregulated in OC tissues and cells.In conclusion, the present study demonstrated that SNHG20 regulates OC development via modulation of the miR-338-3p/MCL1 axis, providing the theoretical basis for the treatment of OC. Yes Besides, mouse xenograft assay was carried out to explore the effect of SNHG20 on tumor growth in vivo. 33552251 SNHG20 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cells and tissues Interaction [miR-140-5p-ADAM10 axis] In Vivo Experiment//RNA Pull-Down//cell invasion assay//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay QRT-PCR showed that SNHG20 expression was significantly increased in cervical cancer. MiR-140-5p acted as a downstream target of SNHG20. SNHG20 inhibition or miR-140-5p overexpression reduced cervical cancer cells proliferation and invasion ability. Furthermore, we identified that ADAM10 could act as a potential target of miR-140-5p. MEK/ERK signaling could be inhibited by miR-140-5p mimics in cervical cancer cells. In addition, ADAM10 overexpression abrogated the effect of miR-140-5p mimics on cervical cancer cells proliferation and invasion. Yes SNHG20 inhibition or miR-140-5p overexpression reduced cervical cancer cells proliferation and invasion ability. 29604594 SNHG20 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cell lines Interaction(miR-217) CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay SNHG20 was upregulated in ovarian cancer tissues and cell lines. MiR-217 was downregulated in ovarian cancer tissues and cells, and was negatively regulated by SNHG20. Yes Overexpression of SNHG20 promoted ovarian cancer cell proliferation and invasion. 34302635 SNHG20 LncRNA Homo sapiens Ovarian Neoplasms OC cell lines Interaction(miR-148a ) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Significant higher expression of SNHG20 was observed in OC cell lines. SNHG20 enhanced ROCK1 expression by sponging miR-148a, and the direct binding between SNHG20/ROCK1 and miR-148a was identified. Yes SNHG20 markedly promoted the invasion, migration, proliferation and inhibited the apoptosis of OC cells. 34836544 SNHG20 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cell lines Regulation[Wnt/β-catenin signalling pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay The resulting data indicated that SNHG20 was significantly upregulated in bladder cancer tissues and cell lines, compared with its expression in adjacent non?tumour tissues and the SV?HUC?1 normal urinary tract epithelial cell line, respectively. Investigations into the mechanism revealed that the inhibition of SNHG20 suppressed the activation of Wnt/β‑catenin signalling and the expression of certain key genes in bladder cancer cells. In addition, the high expression of SNHG20 was associated with advanced clinical stage, lymph node metastasis, and reduced patient survival rate. Yes The knockdown of SNHG20 caused a significant reduction in cancer cell survival, proliferation, colony formation, migration and invasion, and induced cell apoptosis. Additionally, the inhibition of SNHG20 reduced tumour growth in vivo. 30106094 SNHG20 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Regulation[targeting miR-197/LIN28 axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot LncRNA SNHG20 was Expression[up-expression]-regulated in OSCC tissue compared with adjacent non-tumour tissue. Meanwhile, SNHG20 was overexpressed in cancer stem-like cells. Bioinformatics and luciferase reporter assay revealed that miR-197 targeted the 3'-untranslated regions of SNHG20 and LIN28 by complementary binding. Validation experiments confirmed the associated functions of SNHG20/miR-197/LIN28 axis on OSCC proliferation and stemness. Yes vitro and in vivo, loss-of-function experiments showed that lncRNA SNHG20 knockdown inhibited proliferative ability, mammosphere-forming ability, ALDH1 expression, stem factors (LIN28, Nanog, Oct4, SOX2) and tumour growth. 30394668 SNHG20 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissue Expression[highly expressed] CCK8//qRT-PCR//Colony Formation Assay//Western Blot It was demonstrated that SNHG20 expression was significantly increased in OSCC tissue specimens, compared with in adjacent non-tumor tissue specimens. The increased SNHG20 expression in OSCC tissue specimens was associated with tumor differentiation and Tumor-Node-Metastasis stage. Kaplan-Meier analysis and log-rank tests indicated that Higher SNHG20 expression predicted a poor overall survival (OS) rate in patients with OSCC. Multivariate Cox proportional hazards regression analysis demonstrated that increased SNHG20 expression was an independent predictor for the OS of patients with OSCC. Yes Knockdown of SNHG20 expression in OSCC cells suppressed proliferation. 30655853 SNHG20 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck tissues Interaction(microRNA-19b-3p/RAB14 axis ) qRT-PCR//MTT The results indicated that lncRNA SNHG20 was upregulated in the tissues. Furthermore, bioinformatic analysis showed that both SNHG20 and RAB14 could bind to miR-19b-3p. RAB14 was upregulated, and miR-19b-3p was downregulated in the tissues. Yes The knockdown of SNHG20 inhibited cell proliferation, migration, and invasion. Contrarily, the knockdown of miR-19b-3p reversed the effects of si-SNHG20 on cell proliferation, migration, and invasion, and the overexpression of RAB14 reversed the effects of miR-19b-3p mimic on the cell biological functions. 34282711 SNHG20 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Expression[highly expressed] qRT-PCR Our results indicated SNHG20 was overexpressed in osteosarcoma tissues and cell lines compared with paired non-tumor tissues and normal human osteoblast cell line, respectively. Moreover, we observed high-expression of SNHG20 was obviously associated with Enneking stage, distant metastasis, and histological grade. SNHG20 expression was negatively associated with overall survival, and high-expression of SNHG20 was an independent unfavorable prognostic factor in osteosarcoma patients. Yes Furthermore, SNHG20 promoted osteosarcoma cell migration and invasion through modulating epithelial-mesenchymal transition -associated genes. 30120876 SNHG20 LncRNA Homo sapiens Glioma Glioma tissues Interaction[silencing P21] CCK8//qRT-PCR//Colony Formation Assay//Western Blot Our results suggested the high expression of lncRNA SNHG20 in human glioma tissues compared with normal brain tissues.Consequently, the expression of CCNA1 was inhibited, and the expression of P21 was up-regulated in U87 cells. Our results suggested the high expression of lncRNA SNHG20 in human glioma tissues compared with normal brain tissues, which was related to recurrence-free survival and poor overall survival in glioma patients. According to the existing retrospective cohort study, high lncRNA SNHG20 expression was associated with tumor size, extent of resection, WHO grade, follow-up time, survival status and recurrence. Yes Besides, knocking down the expression of lncRNA SNHG20 could inhibit the proliferation and colony formation abilities of glioma U87 cells through cell cycle arrest. 30774368 SNHG20 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Regulation(DDX17) Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay SNHG20 is highly expressed in PCa tissues and cell lines. Mechanistically, SNHG20 was verified to act as a competing endogenous RNA (ceRNA) to upregulate DDX17. DDX17 is also highly expressed and has oncogenic roles in PCa. Furthermore, the expression of DDX17 is significantly positively correlated with that of SNHG20 in PCa tissues. Depletion of DDX17 reverses the oncogenic roles of SNHG20 in PCa. High expression of SNHG20 is positively correlated with high Gleason score and advanced tumor stage. Yes Functional experiments revealed that overexpression of SNHG20 promotes PCa cell proliferation and migration. SNHG20 knockdown represses PCa cell proliferation and migration. 34900057 SNHG20 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction[MDM2-p53 pathway ] CCK8//qRT-PCR//Western Blot SNHG20 was overexpressed in glioma tissues and cell lines.Molecular studies uncovered that SNHG20 acted as a competing endogenous RNA (ceRNA) to sponge the expression of miR-4486. MiR-4486 was down-regulated in glioma tissues and significantly inversely correlated with the expression of SNHG20. Restoration of miR-4486 remarkably attenuated the promotion effect of SNHG20 on the growth of glioma cells. Further study revealed that miR-4486 targeted the E3 ubiquitin ligase mouse double minute 2 (MDM2) and negatively regulated the expression of MDM2. Down-regulation of MDM2 by miR-4486 increased the abundance of p53 in glioma cells. Yes Down-regulation of SNHG20 suppressed the proliferation, migration and induced apoptosis of glioma cells. 31298384 SNHG20 LncRNA Homo sapiens Glioma glioma tissues Regulation[PTEN/PI3K/AKT signaling pathway] CCK8//qRT-PCR//Tunel//Western Blot The expression level of SNHG20 messenger RNA (mRNA) in glioma tissues was significantly higher than that in para-carcinoma tissues (p<0.05). After the inhibition of siRNA on SNHG20, the proliferation of U118 and U251 cells was significantly inhibited, and the expression of Bax was significantly up-regulated, while that of Bcl-2 was down-regulated. The TUNEL results showed that the number of apoptotic cells in SNHG20 siRNA group was about 12 times that in control group (p<0.05). After SNHG20 knockout, the protein expressions in the PTEN/PI3K/AKT signaling pathway were inhibited (p<0.05). Yes After the inhibition of siRNA on SNHG20, the proliferation of U118 and U251 cells was significantly inhibited 30657567 SNHG20 LncRNA Homo sapiens Glioblastoma glioblastoma tissues and cell lines Regulation[PI3K/Akt/mTOR signaling pathway] qRT-PCR In this study, we found that SNHG20 was significantly upregulated in glioblastoma tissues and cell lines.Furthermore, western blotting demonstrated that the PI3K/Akt/mTOR signaling pathway was activated by SNHG20 in glioblastoma cells. At last, rescue assays validated that PI3K/Akt/mTOR signaling pathway involved in the glioblastoma progression mediated by SNHG20. Taken together, this study revealed that SNHG20 regulated PI3K/Akt/mTOR signaling pathway to promote tumorigenesis and stemness of glioblastoma. Survival analysis suggested that high expression of SNHG20 indicated the low overall survival rate of glioblastoma patients. Yes expression of SNHG20 indicated the low overall survival rate of glioblastoma patients. Subsequently, gain or loss-of-function assays were carried out to examine the effect of SNHG20 on glioblastoma cell proliferation and apoptosis. We found that SNHG20 knockdown obviously suppressed cell proliferation, increased cell apoptosis and impaired stem properties, while SNHG20 overexpression led to the opposite results. In vivo experiment demonstrated that knockdown of SNHG20 efficiently suppressed cell growth in vivo. 30943748 SNHG20 LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues and cell lines regulation[miR-342/DDX49 axis] qRT-PCR//Luciferase Report Assay SNHG20 and DDX49 were overexpressed, while miR-342 was lowly expressed in lung adenocarcinoma tissues and cell lines. Our findings demonstrate that SNHG20/miR-342/DDX49 axis plays an important role in lung adenocarcinoma, providing a novel insight into the treatment of lung adenocarcinoma. Yes Knockdown of SNHG20 suppressed cell proliferation, invasion and enhanced cell apoptosis. 33089952 hsa_circ_0000045 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues and HNSCC cell lines Regulation(HSP70) RNA Pull-Down//Western Blot//Transfection//Migration Assay//qRT-PCR//RNA-seq//Invasion Assay Great alterations in circRNA profiles were detected in HNSCC tissues, including the elevated expression of circ_0000045. Results also showed that circ_0000045 was associated with multiple RNA-binding proteins in HNSCC cells, such as HSP70. Moreover, circ_0000045 knockdown enhanced HSP70 expression and inhibited JNK2 and P38's expression in HNSCC cells, which were oppositely regulated by circ_0000045's overexpression. Yes As observed, silencing of circ_0000045 effectively repressed the proliferation, migration, and invasion of HNSCC cell lines (FaDu and SCC-9). Contrarily, circ_0000045's overexpression promoted the proliferation, migration, and invasion in FaDu and SCC-9 cells. 35854245 SNHG20 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues,cell lines Interaction[regulating miR-140] CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining The SNHG20 expression in LSCC tissues or cells remarkably increased than controls, and the difference was statistically significant. MiR-140 was negatively correlated with SNHG20 in LSCC tissues and cells. Dual-luciferase reporter gene assay showed that SNHG20 could be targeted by miR-140 through a certain binding site. The cell rescue experiment also indicated that there was a mutual regulation between SNHG20 and miR-140, which could together affect the malignant progression of LSCC. The LSCC patients with the high expression level of SNHG20 were more likely to develop advanced tumor compared with patients with low expression of SNHG20. Moreover, the LSCC patients with the high expression level of SNHG20 had a shorter overall survival than those with low level. Yes The cell proliferation ability significantly decreased in the SNHG20 knockdown group, while notably increased in SNHG20 overexpression group. 31081112 SNHG20 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Regulation[miR-6516-5p/SCGB2A1 axis] qRT-PCR//Luciferase Report Assay SHNG20 expression was found markedly elevated in PCa tissues and cell lines. In conclusion, this finding suggests the SNHG20/miR-6516-5p/SCGB2A1 axis in PCa tumorigenesis, providing the novel insight for the molecular mechanism of PCa. Yes Overexpression of SNHG20 increased PCa cell proliferation and invasion but decreased cell apoptosis. However, the knockdown of SNHG20 will cause the opposite effects on PCa cell behaviors. 31497231 circMAPK9 CircRNA Homo sapiens Arthritis, Rheumatoid FLS Interaction(miR-140-3p/PPM1A axis) Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//ELISA//Transwell Assay CircMAPK9 and PPM1A were upregulated and miR-140-3p was downregulated in RA patients and FLSs from RA patients (RA-FLSs). CircMAPK9 silence suppressed cell proliferation, migration, invasion, inflammatory response, and promoted apoptosis in RA-FLSs. MiR-140-3p was a target of circMAPK9, and miR-140-3p downregulation attenuated the effects of circMAPK9 knockdown on cell progression and inflammatory response in RA-FLSs. PPM1A was targeted by miR-140-3p, and circMAPK9 could regulate PPM1A expression by sponging miR-140-3p. Furthermore, miR-140-3p could impede cell biological behaviors in RA-FLSs via targeting PPM1A. Yes CircMAPK9 silence suppressed cell proliferation, migration, invasion, inflammatory response, and promoted apoptosis in RA-FLSs. 34154607 SNHG15 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[inhibiting miR-338-3p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay Our results showed that SNHG15 was up-regulated in CRC tissues compared with paired NCTs (P < 0.0001). The results of mechanism experiments showed that SNHG15 could bind to miR-338-3p and block its inhibition on the expression and activity of FOS or RAB14. In conclusion SNHG15 promotes cell proliferation through SNHG15/miR-338-3p/FOS-RAB14 axis in CRC. Yes SNHG15 overexpression could promote cell proliferation and inhibit cell apoptosis. Animal experiments showed that up-regulation of SNHG15 promoted tumor growth in vivo. 30945457 SNHG15 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues,cell lines Interaction[AIF] RNA Pull-Down//Western Blot//qRT-PCR//RIP//RNA-seq//Colony Formation Assay//Transwell Assay To confirm this observation, we obtained 36 fresh colorectal cancer tumors and their adjacent normal tissues immediately after surgery from Iranian CRC patients (Table ​(Table1).1). SNHG15 expression was examined by qRT-PCR and its upregulation was observed in tumoral samples (Fig. ​(Fig.1d,1d, p < 0.001). Moreover, we profiled SNHG15 expression in ten CRC cell lines (Caco-2, DLD-1, HCT 116, HT-29, LoVo, LS513, RKO, SW480, SW620 and T84) and found this lncRNA ubiquitously expressed in all tested CRC cell lines and with higher levels compared to the non-cancerous HDFa cell line (Fig. ​(Fig.11e). Yes The depletion of SNHG15 by siRNA or CRISPR-Cas9 inhibits cell proliferation and invasion, decreases colony formation as well as the tumorigenic capacity of CRC cells, whereas its overexpression leads to opposite effects. 31014355 SNHG10 LncRNA Homo sapiens Prostatic Neoplasms PC cells and tissues Expression [highly expressed] ChIP//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//Transwell Assay In this study, we investigated the role of SNHG10 in PC and found that SNHG10 expression was significantly increased in datasets extracted from The Cancer Genome Atlas. Increased expression of SNHG10 was related to advanced clinical parameters. Increased expression of SNHG10 was related to advanced clinical parameters. Receiver operating curve analysis revealed the significant diagnostic ability of SNHG10 (AUC = 0.805). Yes In addition, immune infiltration analysis, and GSEA showed that SNHG10 expression was correlated with oxidative phosphorylation and immune infiltrated cells. Finally, we determined that SNHG10 regulated cell proliferation, migration, and invasion of PC in vitro. 34676212 SNHG10 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-21] CCK8//qRT-PCR We observed the expression of SNHG10 was down-regulated in non-small cell lung cancer (NSCLC) compared with that in non-tumor tissues. SNHG10 may involve in NSCLC cell proliferation by regulating the miR-21 gene methylation. Moreover, we found that high expression levels of SNHG10 predicted favorable survival of NSCLC patients, and the expression of miR-21 were increased in NSCLC and inversely correlated with SNHG10 expression. Yes In NSCLC cells, overexpression of SNHG10 resulted in increased miR-21 gene methylation and decreased miR-21 expression. Moreover, overexpression of SNHG10 attenuated the enhancing effect of miR-21 overexpression on cell proliferation. 33081752 SNHG10 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue interaction[miR-543,SIRT1 ] CCK8//qRT-PCR//Western Blot We confirmed the downregulation of SNHG10 in NSCLC. In conclusion, SNHG10 sponges miR-543 to upregulate tumor suppressive SIRT1 in NSCLC to suppress cell proliferation. In addition, low expression level of SNHG10 predicted the poor survival of NSCLC patients. Yes Cell proliferation assay showed that SNHG10 and SIRT1 overexpression led to the decreased proliferation rate of NSCLC cells. 32319822 SNHG10 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue samples and cells Expression(highly expressed) CCK8//qRT-PCR//ELISA//Western Blot RNA sequencing revealed that SNHG10 expression was upregulated in EMT-exo compared with that in non-EMT-exo. Moreover, SNHG10 expression was upregulated in tumor tissues in CRC, which was associated with poor prognosis. Moreover, SNHG10 expression was upregulated in tumor tissues in CRC, which was associated with poor prognosis. Yes Overexpression of SNHG10 in exosomes (oe-lnc-SNHG10 exo) significantly suppressed the viability and cytotoxicity of NK cells. 34641864 SNHG10 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues and cells Interaction(SNHG10/miR-200a-3p/BIN1 axis) Western Blot//qRT-PCR//RIP//FISH//IHC Altogether, SNHG10 sponges miR-200a-3p to upregulate BIN1 and thereby exerting its tumor-suppressive effects in EOC. Therefore, the SNHG10/miR-200a-3p/BIN1 axis may act as a potential predictive biomarker and therapeutic target for treating EOC. Kaplan-Meier analysis and COX proportional hazard progression model showed that low expression of SNHG10 was correlated with a poor prognosis of EOC patients. Yes Overexpressing SNHG10 suppressed the proliferation, colony formation, migration, and invasion of EOC cells. 35149697 circVPS13C CircRNA Homo sapiens Pituitary Neoplasms NFPA samples Regulation(IFITM1/MAPK) In Vivo Experiment//Western Blot//qPCR//FISH//migration assay//Cell Apoptosis Assay//Microarray//Colony Formation Assay CircVPS13C is significantly upregulated in NFPA samples and cell lines. Mechanistically, circVPS13C silencing increases the expression of IFITM1 and subsequently activates its downstream genes involved in MAPK- and apoptosis-associated signaling pathways. Rescue experiments show that IFITM1 overexpression partly reverses the biological effects of circVPS13C. Further studies reveal that circVPS13C inhibits IFITM1 expression through a novel mechanism mainly by competitively interacting with RRBP1, a ribosome-binding protein of the endoplasmic reticulum membrane, and thereby alleviating the stability of IFITM1 mRNA. Clinically, circVPS13C expression is markedly higher in high-risk NFPA samples and is downregulated in patient serum 7 days post-transsphenoidal adenoma resection. Yes Gain- and loss-of-function experiments demonstrate that silencing circVPS13C inhibits the proliferation of pituitary tumor cells in vitro and in vivo. 35091683 SNHG10 LncRNA Homo sapiens Osteosarcoma OS cells and tissues Interaction(miR-141-3p/WTAP axis) CCK8//qRT-PCR The present work found that SNHG10 expression increased within OS cells and tissues, while suppressing its expression decreased OS cell proliferation, migration, invasion, but increased their apoptosis. . As for the mechanism, we confirmed that SNHG10 could bind to miR-141-3p, while the latter could bind to WTAP. SNHG10 upregulated WTAP through decreasing miR-141-3p expression. Yes The present work found that SNHG10 expression increased within OS cells and tissues, while suppressing its expression decreased OS cell proliferation, migration, invasion, but increased their apoptosis. More importantly, SNHG10 deletion remarkably reduced proliferation, migration, and invasion of cells, but accelerated their apoptosis. However, when cells were subjected to miR-141-3p inhibitor cotransfection or overexpressed WTAP, these effects were partially recovered. 35274397 SNHG10 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML samples Interaction(miR-621 methylation) qRT-PCR In this study, we found that the expression of SNHG10 was upregulated and the expression of miR-621 was downregulated in AML samples. Bioinformatics analysis showed that SNHG10 could be targeted by miR-621. In AML cells, miR-621 overexpression downregulated the expression of SNHG10, while SNHG10 overexpression could not affect the expression of miR-621. However, it was found that the reduction of miR-621 caused by SNHG10 overexpression might be due to the increase of miR-621 methylation. Moreover, SNHG10 and miR-621 were inversely correlated across AML samples, and a high level of SNHG10 predicted poor survival of AML patients. Yes n addition, SNHG10 overexpression significantly promoted BMMNC proliferation, whereas miR-621 overexpression inhibited BMMNC proliferation and abolished the effect of SNHG10 overexpression on BMMNC proliferation. 33688254 SNHG10 LncRNA Homo sapiens Glioma cell lines regulation[miR-532-3p/FBXL19 axis] RNA Pull-Down//ChIP//Wound Healing Assay//Tunel//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay High level of SNHG10 was detected in glioma cells. SNHG10 was transcriptionally activated by ETS1 and played an oncogenic role in glioma by sponging miR-532-3p and up-regulating FBXL19. Yes Functional assay confirmed that SNHG10 promoted the proliferation, migration, invasion and stemness of glioma cells. 33298070 SNHG1 LncRNA Homo sapiens Stomach Neoplasms GC cell lines and tissues Regulation[miR-140/ADAM10 axis] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay Here, we reported that SNHG1 expression was significantly increased in GC cell lines and tissues.Mechanismly, it was found that SNHG1 functioned as a competing endogenous RNA to repress miR-140 expression and thereby elevated its down-stream target ADAM10. Yes Knockdown of SNHG1 impeded cell growth via disturbing cell cycle distribution and protecting cells from apoptosis.Nevertheless, SNHG1 down-regulation decreased cell invasive ability and reversed epithelial-mesenchymal transition (EMT) phenotype. 30391432 SNHG10 LncRNA Homo sapiens Stomach Neoplasms cells regulation[SNHG10/DDX54/PBX3 Feedback Loop ] RNA Pull-Down//qRT-PCR//RIP//Luciferase Report Assay//ChIP SNHG10 was expressed at a high level in GC cells. SNHG10 facilitates cell growth by affecting DDX54-mediated PBX3 mRNA stability in GC. Yes SNHG10 knockdown resulted in the inhibition on GC cell proliferation, migration but induced cell apoptosis. 32712782 circNFIX LncRNA Homo sapiens Pituitary Neoplasms pituitary adenoma tissues Interaction( miR-34a-5p/CCNB1) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//cell invasion assay//IHC In pituitary adenoma tissues, the expression of circNFIX and CCNB1 was upregulated, while miR-34a-5p expression was downregulated. In conclusion, CircNFIX affects cell invasion, migration, and proliferation in pituitary adenomas by sponging miR-34a-5p through CCNB1. Yes  The silencing of circNFIX or overexpression of miR-34a-5p inhibited cell invasion, migration and proliferation. Inhibition of miR-34a-5p expression reversed the inhibitory effect of circNFIX silencing on the progression of pituitary adenoma. 33359304 SNHG1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction( miR-195-5p/YAP1 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay SNHG1 and YAP1 levels were elevated and miR-195-5p level was reduced in GC.Downregulated SNHG1 suppressed tumor growth in vivo. SNHG1 bound to miR-195-5p, and miR-195-5p directly targeted YAP1. Yes Reduction of SNHG1 or elevation of miR-195-5p retarded GC cell biological activity in vitro. 35819551 SNHG1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissue,cell lines (BT474、MCF7、MDA-MB-453、MDA-MB-231、HCC1937、MCF10A) Expression[Expression[Expression[highly expressed]-expression]-expression] CCK8//qRT-PCR//Western Blot LncRNA SNHG1 expression in tumor tissue was increased compared with paired adjacent tissue, and it correlated with higher T stage and worse overall survival (OS) in breast cancer patients. LncRNA SNHG1 expression was also elevated in breast cancer cell lines compared with normal breast epithelial cell line. LncRNA SNHG1 expression in tumor tissue was increased compared with paired adjacent tissue, and it correlated with higher T stage and worse overall survival (OS) in breast cancer patients. LncRNA SNHG1 expression was also elevated in breast cancer cell lines compared with normal breast epithelial cell line. Yes Cell Counting Kit-8 (CCK8) assay revealed that lncRNA SNHG1 overexpression promoted while lncRNA SNHG1 shRNA reduced cell proliferation, and Annexin V-fluorescein isothiocyanate/propidium iodide staining (AV/PI) assay illustrated that lncRNA SNHG1 overexpression decreased while lncRNA SNHG1 shRNA increased cell apoptosis rate. In addition, Western Blot assay disclosed that lncRNA SNHG1 overexpression Expression[down-expression]regulated while lncRNA SNHG1 shRNA Expression[Expression[up-expression]-expression]regulated pro-apoptotic marker (C-Caspase3) expression, and lncRNA SNHG1 overexpression increased while lncRNA SNHG1 shRNA decreased anti-apoptotic marker (p-P38) expression. 35116793 SNHG1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction[regulating miR-382] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay SNHG1 upregulation was observed in breast cancer tissues and cells.SNHG1 promotes breast cancer through the regulation of miR-382-5p and EMT markers. Yes Knockdown of SNHG1 attenuated breast cancer proliferation, colony formation, migration and invasion. 31354360 SNHG1 LncRNA Homo sapiens Breast Neoplasms Breast cancer tissue regulation[SNHG/miR-573/LMO4 axis] Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay In the present study, increased expression levels of SNHG1 were noted in breast cancer tumors following analysis of differentially expressed lncRNAs between 1,063 tumor and 102 normal tissues derived from The Cancer Genome Atlas Breast Invasive Carcinoma (TCGA‑BRCA) dataset. The present study demonstrated that SNHG1 acts as a novel oncogene in breast cancer via the SNHG/miR-573/LMO4 axis and that it could be a promising therapeutic target for patients with breast cancer. Yes In vitro experiments indicated that LMO4 overexpression could reverse siSNHG1‑induced cell growth arrest, cell cycle redistribution and inhibition of cell migration in breast cancer cells. Moreover, the tumor xenograft model indicated that SNHG1 knockdown inhibited MDA‑MB‑231 growth in vivo and LMO4 overexpression reversed the tumor growth inhibition induced by SNHG1 knockdown. 32323846 SNHG1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines regulation[ SNHG1/miR-193a-5p/HOXA1] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Here, we found that SNHG1 expression was significantly upregulated in human breast cancer tissues and cell lines. In summary, our study reveals a novel SNHG1/miR-193a-5p/HOXA1 competing endogenous RNA regulatory pathway in breast cancer progression and may provide new strategies for breast cancer therapy. Yes We explored the function of SNHG1 in breast cancer cells using in vitro and in vivo experiments and found that SNHG1 promotes breast cancer metastasis and proliferation. 32497022 SNHG1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(EZH2) qRT-PCR//RIP//MTT//Luciferase Report Assay//ChIP Our findings demonstrated that SNHG1 is significantly upregulated in breast cancer tissues and cells. High SNHG1 levels were closely linked to reduced survival rates in breast cancer patients. Yes SNHG1 silencing has been shown to inhibit the proliferative, migratory, and invasive activity of breast cancer cells. Moreover, SNHG1 silencing enhanced cisplatin (DDP) sensitivity of these cells through improving DDP-induced cell apoptosis. Mechanistically, SNHG1 was found to interact with enhancer of zeste homolog 2 (EZH2), recruiting EZH2 to trigger trimethylation of histone H3 lysine 27 (H3K27me3), thus epigenetically inhibiting miR-381 transcription in these cells. 34806925 SNHG1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell lines,tissue interaction[miR-497] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The transcript level of lnc-SNHG1 was higher in lung adenocarcinoma specimens and NSCLC cell lines than in noncancer tissue and cells. Furthermore, our study demonstrated that the lnc-SNHG1 regulated the expression of the insulin-like growth factor 1 receptor (IGF1-R) by acting as a sponge of miR-497 in NSCLC. Yes The inhibitory effect of si-lnc-SNHG1 on NSCLC cell proliferation, migration and invasion could be rescued by miR-497 inhibition, while the overexpression of miR-497 could reverse the effect of lnc-SNHG1 overexpression. 30454699 SNHG11 LncRNA Homo sapiens Pancreatitis AP pancreatic tissue and AP cell models Interaction(SNHG11/miR-7-5p/PLCB1/p38MAPK Axis) Western Blot//CCK8//qRT-PCR//RIP//RNA-seq//H&E Staining//ELISA//Bioinformatics Analysis Low expression of SNHG11 and PLCB1 and high expression of miR-7-5p were observed in AP pancreatic tissue and AP cell models. SNHG11 overexpression inhibited apoptosis and inflammatory responses induced by caerulein. Yes SNHG11 overexpression inhibited apoptosis and inflammatory responses induced by caerulein. 36611865 hsa_circ_0002594 CircRNA Homo sapiens Asthma asthma patients and HASMC Interaction(miR-139-5p/TRIM8 axis) Western Blot//Wound Healing Assay//Transfection//qRT-PCR//RIP//Luciferase Report Assay//ELISA//EdU Staining//Transwell Assay Circ_0002594 and TRIM8 were elevated in asthma patients and PDGF-BB-treated HASMC, and the miR-139-5p level was decreased . Mechanism analysis exhibited that circ_0002594 could regulate TRIM8 expression through sponging miR-139-5p. Yes Furthermore, circ_0002594 knockdown could suppress PDGF-BB- stimulated HASMC damage. 35470728 SNHG11 LncRNA Homo sapiens Stomach Neoplasms Gastric Cancer tissues,cell lines regulation[Wnt/β-Catenin Pathway] RNA Pull-Down//ChIP//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Transwell Assay We show that SNHG11 is upregulated in GC, and that its upregulation correlated with dismal patient outcomes.Intriguingly, SNHG11 regulated autophagy in a manner dependent on ATG12 rather than the Wnt/β-catenin pathway, whereas SNHG11 contributed to the malignant behaviors of GC cells via both pathways. We show that SNHG11 is upregulated in GC, and that its upregulation correlated with dismal patient outcomes. Yes Functionally, SNHG11 aggravated oncogenic autophagy to facilitate cell proliferation, stemness, migration, invasion, and epithelial-to-mesenchymal transition (EMT) in GC. 33068778 SNHG12 LncRNA Homo sapiens stomach carcinoma gastric carcinoma tissues and cell line Interaction(microRNA-199a/b-5p) Cell Proliferation Assay//RIP//ChIP Higher lncRNA SNHG12 expression was observed in 6 gastric carcinoma tissues than the paracancerous tissues. RIP experiment confirmed the binding abilities of lncRNA SNHG12, microRNA-199a/b-5p and Argo2. The distinct interaction between lncRNA SNHG12 and microRNA-199a/b-5p was verified by CHIP experiment. Clinical data analysis demonstrated that highly expressed lncRNA SNHG12 was related to tumor size and TNM staging. Survival analysis showed that highly expressed lncRNA SNHG12 in patients with gastric carcinoma was negatively correlated to the overall survival time. Yes Additionally, the expression of lncRNA SNHG12 was positively linked with the proliferative ability of BGC-823. 29565487 SNHG12 LncRNA Homo sapiens Cerebral Ischemia/Reperfusion Injury brain tissue of mice Interaction(miR-136-5p/Bcl-2/ PI3K/AKT pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//FISH//Flow Cytometry//RIP//qRT-PCR//Luciferase Report Assay Here, we show that the expression of SNHG12 was upregulated in the brain tissue of mice exposed to middle cerebral artery occlusion/reperfusion (MCAO/R) and primary mouse cerebral cortex neurons treated with oxygen-glucose deprivation/reoxygenation (OGD/R).In addition, we found that SNHG12 acts as a competing endogenous RNA (ceRNA) with microRNA (miR)-136-5p, thereby regulating the inhibition of its endogenous target Bcl-2. Moreover, SNHG12 was proven to target miR-136-5p, increasing Bcl-2 expression, which finally led to the activation of PI3K/AKT signaling. Yes Mechanistically, SNHG12 knockdown resulted in larger infarct sizes and worse neurological scores in MCAO/R mice.Consistent with the in vivo results, SNHG12 upregulation significantly increased the viability and prevented apoptosis of neurons cultured under OGD/R conditions. 34839459 SNHG12 LncRNA Homo sapiens Cholangiocarcinoma ICC cells Interaction(miR-199a-5p/Klotho) Cell Proliferation Assay//qRT-PCR//Transfection//cell invasion assay The expression of SNHG12 and Klotho was distinctly increased in ICC cells, while miR-199a-5p expressions were decreased. Mechanistically, Knockdown of SNHG12 significantly suppressed the expressions of miR-199a-5p by sponging it, and then increased Klotho expression. Yes Functionally, the silence of SNHG12 inhibited the proliferation and metastasis of ICC cells, while miR-199a-5p overexpression exhibited an opposite result. The final in vivo experiments suggested that the silence of SNHG12 distinctly inhibited tumor growth. 34239888 SNHG12 LncRNA Homo sapiens cervical squamous cell carcinoma CSCC tissues regulation[ERK/Slug pathway] qRT-PCR We found that SNHG12 was significantly overexpressed in CSCC tissues. In addition, SNHG12 could facilitate epithelial-mesenchymal transition through ERK/Slug/E-cadherin pathway at least in part. Yes Functional experiments suggested that SNHG12 knockdown dramatically repressed CSCC cells proliferation, migration, and invasion while induced apoptosis in vitro as well as suppressed tumor growth in vivo. 31943193 SNHG12 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cells Interaction( miR-30a-3p) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay In the present study, we discovered that SNHG12 is up-regulated in ccRCC and that overexpression of SNHG12 predicted poor clinical outcome of ccRCC patients. Furthermore, we discovered that miR-30a-3p, a putative ccRCC inhibitor, was competitively sponged by SNHG12. Via the crosstalk network, SNHG12 was capable of up-regulating multiple target genes of miR-30a-3p, namely, RUNX2, WNT2 and IGF-1R, which have been identified to facilitate tumorigenesis of ccRCC. In the present study, we discovered that SNHG12 is up-regulated in ccRCC and that overexpression of SNHG12 predicted poor clinical outcome of ccRCC patients. Yes SNHG12 knockdown notably inhibited proliferation and migration of RCC cells. 33787057 Snhg12 LncRNA Mus musculus Cerebral Ischemia/Reperfusion Injury brain tissue Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//EdU Staining//IF We found the expression of SNHG12 was up-regulated by cerebral I/R in mice andSH-SY5Y cell model after OGD/R. Yes On the contrary, down-regulation of SNHG12 exacerbated SH-SY5Y cell injury after OGD/R and inhibited autophagy. 31056262 SNHG11 LncRNA Homo sapiens Pancreatic Carcinoma serum of PC patients Interaction(miR-324-3p/VEGFA axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR LncRNA SNHG11 (SNHG11) has been found to display high expression in serum of PC patients, which implies that dysregulated SNHG11 may be related to the development of PC. Exosome-mediated SNHG11 regulated the expression of VEGFA through sponging miR-324-3p. Rescue assays validated that the inhibitory effect of SNHG11 depletion on cell proliferation, migration, and angiogenesis could be reversed by miR-324-3p downregulation or VEGFA upregulation, and the promoting effect of SNHG11 silence on cell apoptosis could be rescued by transfection of miR-324-3p inhibitor or pcDNA3.1-VEGFA. Yes After conducting experiments with constructed models in vitro or in vivo, we found that exosomal SNHG11 promoted cell proliferation, migration, and angiogenesis but impeded cell apoptosis in PC in vitro, and additionally, it facilitated tumor growth in vivo. 34519129 SNHG11 LncRNA Homo sapiens Stomach Neoplasms GC samples and cell lines Interaction(miR-194) In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Compared with normal healthy gastric tissue and mucosal epithelial cell GES-1, SNHG11 and CDC25A expressions were dramatically increased in GC samples and cell lines, whereas microRNA-184 (miR-184) levels were reduced. SNHG11 silencing led to increased miR-184 and reduced CDC25A, whereas miR-184 downregulation recovered the expression of CDC25A. Additionally, miR-184 upregulation also played a role in regulating CDC25A ablation. Yes Downregulated miR-184 expression in SNHG11 silenced GC cells showed that miR-184 inhibition reversed the effect of SNHG11 silencing on the growth, proliferation, apoptosis, and migration of GC cells. Moreover, in vivo xenograft experiments demonstrated that SNHG11 knockdown can inhibit tumor growth. 33816469 SNHG11 LncRNA Homo sapiens Lung Neoplasms regulation[Wnt/β-catenin signaling pathway] qRT-PCR Long noncoding RNA small nucleolar RNA host gene 11 (SNHG11) was found to be upregulated in lung cancer and facilitated lung cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition progression while suppressed cell apoptosis. Hence, SNHG11 was found to promote lung cancer progression by activating Wnt/β-catenin pathway in two different patterns, implying that SNHG11 might contribute to lung cancer treatment by acting as a therapeutic target. Moreover, the high expression of SNHG11 was correlated with poor prognosis of lung cancer patients, TNM stage, and tumor size. Yes Long noncoding RNA small nucleolar RNA host gene 11 (SNHG11) was found to be upregulated in lung cancer and facilitated lung cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition progression while suppressed cell apoptosis. 32239719 SNHG11 LncRNA Homo sapiens Colorectal Neoplasms interaction[c-Myc] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay Here, we found SNHG11, a highly conserved lncRNA, was commonly overexpressed in various cancer including CRC.Taken together, our findings suggested that reciprocal regulation of SNHG11 and c-Myc promotes cell proliferation in CRC. High expression of SNHG11 correlated with poor prognosis in patients with CRC. Yes Gain of function and loss-of function experiments showed that SNHG11 visibly promoted proliferation in CRC cells. 32439170 SNHG11 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues,HCC cells regulation[hsa-miR-184/AGO2] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Transwell Assay LncRNA microarray assay and RT-PCR results revealed that the expression of SNHG11 was increased in HCC tumor tissues and also upregulated in HCC cells. Our study demonstrated that the expression of SNHG11 is higher in HCC; moreover, SNHG11 promotes proliferation, migration, apoptosis, and autophagy by regulating AGO2 via miR-184 in HCC. SNHG11 had a connection with poor survival rate in HCC. Yes Our study demonstrated that the expression of SNHG11 is higher in HCC; moreover, SNHG11 promotes proliferation, migration, apoptosis, and autophagy by regulating AGO2 via miR-184 in HCC. 32021286 SNHG11 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cell lines Interaction(miR-2355-5p/CBX5 axis) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay In the present study, the results indicated SNHG11 was highly expressed in TNBC tissues and cell lines.Furthermore, SNHG11 sponged microRNA 2355-5p (miR-2355-5p) in TNBC. Silencing SNHG11 increased miR-2355-5p expression. In addition, chromobox 5 (CBX5) was identified to be targeted by miR-2355-5p in TNBC. It was also suggested that CBX5 silencing suppressed cell proliferation and migration. Furthermore, overexpressed CBX5 recovered the inhibitive influence of SNHG11 silencing on proliferative and migrative abilities of TNBC cells. Yes Moreover, SNHG11 aggravated cell proliferation and migration, and whereas it attenuated cell apoptosis in TNBC. 34257707 SNHG11 LncRNA Homo sapiens Glioma glioblastoma tissues ,cell lines interaction[miR-154-5p] qRT-PCR//Luciferase Report Assay//Western Blot//Transwell Assay SNHG11 was upregulated in glioblastoma tissues and five malignant glioma cell lines.SNHG11 functioned as an oncogene in glioma and promoted proliferation, invasion, and migration via EMT by sponging miR-154-5p. SNHG11 expression was negatively correlated with overall survival of glioma patients. Yes Moreover, silencing of SNHG11 could decrease glioma cell viability both in vitro and in vivo. Furthermore, the inhibition of SNHG11 suppressed proliferation, invasion and migration via regulating epithelial-mesenchymal transition (EMT). 32432753 SNHG11 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cells Interaction(miR-193a-5p) RNA Pull-Down//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay SNHG11 was evidently high expressed in LUAD cells in comparison to normal lung epithelial cells. As for the mechanisms, SNHG11 activated Notch pathway via regulating Notch3. In addition, SNHG11 competitively bound with miR-193a-5p to up-regulate Notch3. The last rescue assays displayed that SNHG11 affecting LUAD cell malignant behaviors via regulating miR-193a-5p/SNHG11. Yes Moreover, down-regulation of SNHG11 hindered viability, proliferation and migration of LUAD cells as well as tumor growth. 35487027 SNHG11 LncRNA Homo sapiens Prostatic Neoplasms 30 PCa and adjacent normal tissue samples Interaction(miR‑184) In Vivo Experiment//IHC//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay It was revealed that the SNHG11 expression levels were significantly upregulated in PCa tissues, in comparison with those in adjacent normal tissues. Furthermore, SNHG11 was found to positively regulate insulin‑like growth factor 1 receptor (IGF‑1R) expression by sponging microRNA (miRNA/miR)‑184 in PCa cells. Yes Functionally, SNHG11 knockdown significantly suppressed PCa cell proliferation, migration, invasion and metastasis in vitro and in vivo. 34328198 SNHG1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation[ miR-361-3p/FRAT1 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Our results indicated that SNHG1 and FRAT1 were highly expressed in NSCLC tissues and cells.SNHG1 sponged miR-361-3p and negatively regulated miR-361-3p expression. Meanwhile, miR-361-3p targeted FRAT1 and inversely modulated FRAT1 expression. In addition, miR-361-3p inhibition abated the effect of SNHG1 knockdown on FRAT1 expression. Yes SNHG1 silencing inhibited proliferation, induced apoptosis and blocked migration and invasion of NSCLC cells. 31788970 SNHG1 LncRNA Homo sapiens Lung Neoplasms A549 and H1299 cell line Regulation qRT-PCR The conclusion was that the A549 and H1299 groups of shLncRNA16 could significantly reduce the incidence by 64% and 40% percentage points compared with the experimental group, which indicates that LncRNA16 can be used as a potential treatment target for patients. Yes The conclusion was that the A549 and H1299 groups of shLncRNA16 could significantly reduce the incidence by 64% and 40% percentage points compared with the experimental group, which indicates that LncRNA16 can be used as a potential treatment target for patients. 36495499 circASH2L CircRNA Homo sapiens Arthritis, Rheumatoid normal synovial tissues and synovial tissues with RA Interaction(miR-129-5p/HIPK2 axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//ELISA//EdU Staining//Transwell Assay CircASH2L knockdown in RA-FLSs suppressed cell proliferative, migratory, and invasive capacities, triggered cell cycle arrest, promoted apoptosis, and inhibited inflammation. Mechanistically, circASH2L targeted miR-129-5p, and repression of miR-129-5p abolished the functions of circASH2L silencing on the growth, motility, and inflammation of RA-FLSs. Yes CircASH2L knockdown in RA-FLSs suppressed cell proliferative, migratory, and invasive capacities, triggered cell cycle arrest, promoted apoptosis, and inhibited inflammation. 33964939 SNHG1 LncRNA Homo sapiens Leukemia, Myeloid, Acute blood regulation[ miR-489-3p/SOX12/Wnt/β-catenin signaling] qRT-PCR The present study demonstrated that SNHG1 expression was upregulated in AML. Taken together, these data indicate that suppression of SNHG1 downregulates AML cell growth by inactivating SOX12/Wnt/β-catenin signaling via upregulating miR-489-3p. Yes SNHG1 silencing markedly repressed AML cell growth, whereas SNHG1 overexpression had the opposite effect. 32592199 circATRNL1 CircRNA Homo sapiens Endometriosis endometrial cancer cells Interaction(miR-103a-3p /ASIC1 ) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircATRNL1 and ASIC1 were upregulated but miR-103a-3p was downregulated in endometrial cancer cells. Mechanistically, circATRNL1 bound to miR-103a-3p to upregulate a target gene of miR-103a-3p, ASIC1. Yes CircATRNL1 silencing contributed to the decline of proliferation, invasion, migration, and EMT in Ishikawa cells, while miR-103a-3p inhibitor reversed those changes. In addition, the EMT process was aggravated when miR-103a-3p was inhibited and this process was suppressed by silencing ASIC1 in the presence of downregulated miR-101a-3p. 35504053 SNHG1 LncRNA Homo sapiens Osteosarcoma OS tissues,cell lines Interaction[regulates miRNA‑101‑3p] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay In the present study, through reverse transcription‑quantitative polymerase chain reaction analysis, it was first found that the lncRNA SNHG1 was upregulated and miRNA‑101‑3p was downregulated in OS tissues and cell lines. Furthermore, according to a dual‑luciferase assay and western blot analysis, miRNA‑101‑3p was found to be a target of the lncRNA SNHG1 in OS, which further regulated the expression of Rho‑associated coiled‑coil‑containing protein kinase 1 (ROCK1). It was found that the phosphoinositide 3‑kinase/ATK pathway was inactivated and that epithelial‑mesenchymal transition was activated in OS cell lines with overexpression of the lncRNA SNHG1. Yes Second, the knockdown of lncRNA SNHG1 induced cell apoptosis and maintained the cell cycle at the G0/G1 phase, which decreased the overall cell viability. 30592267 hsa_circ_0075503 CircRNA Homo sapiens Endometriosis ESCs Interaction(miR-15a-5p and KLF12) Western Blot//Transfection//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay Circ_0075503 expression was elevated in ectopic endometrium and ectopic ESCs. Down-regulation of circ_0075503 suppressed E2-induced promotion of cell viability, migration and invasion in eutopic ESCs. Circ_0075503 could act as a sponge for miR-15a-5p, and KLF12 was targeted by miR-15a-5p. Inhibition of miR-15a-5p reversed the effects of circ_0075503 knockdown on E2-treated ESCs migration and invasion. Besides, miR-15a-5p repressed E2-induced promotion effects on cell migration and invasion via targeting KLF12. Circ_0075503 could regulate KLF12 expression by sponging miR-15a-5p. Knockdown of circ_0075503 inhibited E2-induced enhancement of cell migration and invasion in eutopic ESCs by regulating miR-15a-5p/KLF12 axis, indicating a novel target for the treatment of endometriosis. Yes Inhibition of miR-15a-5p reversed the effects of circ_0075503 knockdown on E2-treated ESCs migration and invasion. 34117589 circPIP5K1A CircRNA Homo sapiens Endometriosis EM tissues and cells Interaction( miR-153-3p/TMSB4X axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay Herein, we found remarkable high circPIP5K1A expression in EM tissues and cells. Also, we found that circPIP5K1A regulated TMSB4X level via interaction with miR-153-3p in EM cells. Besides, circPIP5K1A promoted EM progression via TMSB4X. Moreover, TMSB4X could activate the TGF-β signaling in hEM15A cells. Yes Silencing of circPIP5K1A suppressed proliferation, restrained cell cycle, increased cell apoptosis, and decreased migration and invasion in EM cells.In addition, miR-153-3p inhibition could abrogate the impacts of circPIP5K1A knockdown on EM progression in vitro. 34546850 SNHG1 LncRNA Homo sapiens Parkinson Disease neuroblastoma cells Interaction( miR-181a-5p/CXCL12 axis) Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Viability Assay We discovered that SNHG1 was significantly elevated, while miR-181a-5p was decreased in N-methyl-4-phenylpyridinium (MPP+)-treated neuroblastoma cells in dose-dependent manners. SNHG1 directly bound to miR-181a-5p, and miR-181a-5p inhibition could block the action of SNHG1 knockdown on MPP+-induced neurotoxicity in neuroblastoma cells. CXCL12 was identified as a downstream target of miR-181a-5p, and the impact of miR-181a-5p on MPP+-induced neuronal damage could be attenuated by CXCL12 overexpression. Yes MPP+ induced cell viability inhibition and apoptosis promotion, while these effects were reversed by SNHG1 knockdown or miR-181a-5p re-expression. 33389428 SNHG1 LncRNA Homo sapiens Parkinson Disease Human neuroblastoma cell lines Regulation(miR-216a-3p/Bcl-2-associated X protein) qRT-PCR//Luciferase Report Assay//Western Blot The expression of miR-216a-3p was decreased in the PD model cells, and re-expression reversed the high apoptotic rate and cell vitality inhibition in PD model cells. SNHG1 interacted with miR-216a-3p and negatively regulated its upstream molecules, while miR-216a-3p attenuated the effect of SNHG1 knock-down on neurons. The overexpression of BAX in the PD cell model blocked the damage by miR-216a-3p to neurons. At the same time, SNHG1 acted as a coordinator, mediating the regulation of BAX via miR-216a-3p, thereby affecting the activity and apoptotic rate of neurons in the PD model. Yes The overexpression of BAX in the PD cell model blocked the damage by miR-216a-3p to neurons. 34164485 SNHG1 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow Expression[highly expressed] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Here, we show that SNHG1 is highly expressed in AML specimens from non-M3 patients, as well as AML cell lines.Mechanistically, we found that an anti-tumor microRNA-101 (miR-101) is upregulated and its target genes are downregulated in AML cells after SNHG1 knockdown. Further investigations display that SNHG1 can serve as a competing endogenous RNA to inhibit miR-101. Yes Notably, SNHG1 facilitates the proliferation and inhibits the apoptosis of AML cells in vitro Consistent with these findings, knockdown of SNHG1 significantly inhibits AML progression in an immunodeficient mouse model. 31615767 hsa_circ_0000673 CircRNA Homo sapiens Endometriosis eutopic and normal endometrial cells Interaction(Mir-616-3p/PTEN Axis) Western Blot//Transfection//Wound Healing Assay//CCK8//FISH//qRT-PCR//Luciferase Report Assay//Colony Formation Assay We demonstrated that knockdown of circ_0000673 significantly increased the proliferation and migration of eutopic and normal endometrial cells. Bioinformatics analysis predicted that circ_0000673 might act as a sponge for miR-616-3p. We found that the effect of circ_0000673 knockdown could be recovered by miR-616-3p inhibitor and enhanced by miR-616-3p mimics. qPCR and western blot assays showed that circ_0000673 knockdown could decrease the expression of PTEN and increase the expression of PI3K and p-AKT. PTEN was confirmed to be a target of miR-616-3p. Yes We demonstrated that knockdown of circ_0000673 significantly increased the proliferation and migration of eutopic and normal endometrial cells. 34522177 circRTN4 CircRNA Homo sapiens Lupus Nephritis human renal mesangial cells Interaction(miR-513a-5p/FN axis) In Vivo Experiment//Transfection//Flow Cytometry//qRT-PCR//FISH//IF In the present study, we clarified that hsa_circ_0054595 (circRTN4) was upregulated in human renal mesangial cells (HRMCs). In cultured HRMCs, circRTN4 could enhance FN expression by directly interacting with miR-513a-5p. Our findings indicated that circRTN4 exacerbates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis. Clinically, high levels of circRTN4 were found in peripheral blood mononuclear cells and kidney tissues of LN patients, hence serving as an effective biomarker for LN detection and a novel therapeutic target. Yes High circRTN4 expression in monocytes disseminated into HRMCs in an exosomal manner, thereby accelerating cell proliferation and extracellular matrix deposition. In addition, knockdown of circRTN4 in the kidney or peripheral blood alleviated renal damage in MRL/lpr and BALB/c mice. 35523949 circZFPM2 CircRNA Homo sapiens Endometriosis ectopic endometrial tissues Interaction(miR-205-5p/ZEB1 ) Transfection//Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//IHC//Bioinformatics Analysis The up-regulated circZFPM2 in ectopic endometrial tissues was previously screened by circRNA high-throughput sequencing and was furtherly validated by quantitative real time reverse transcriptase polymerase chain reaction (RT-qPCR) . Luciferase reporter assays validated that circZFPM2 could directly target miR-205-5p and miR-205-5p target ZEB1. Yes Overexpression of circZFPM2 promoted the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in Ishikawa and End1/E6E7 cells, whereas silencing circZFPM2 produced the opposite effect. 34517087 SNHG1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues Regulation[PI3K/AKT signaling pathway] CCK8//qRT-PCR//Flow Cytometry//Western Blot Herein, we found that SNHG1 was highly expressed in PDAC tissues in comparison with adjacent noncancerous tissues, being closely related to tumor size and TNM stage.Finally, an activator (740Y-P) and inhibitor (LY294002) of the PI3K/AKT signaling pathway were used in the western blot assays and the following rescue experiments, demonstrating that SNHG1 facilitates cell proliferation and tumorigenicity partly via the PI3K/AKT signaling pathway in PDAC. Herein, we found that SNHG1 was highly expressed in PDAC tissues in comparison with adjacent noncancerous tissues, being closely related to tumor size and TNM stage. Yes Functionally, silencing of SNHG1 could significantly inhibit cell proliferation, promote cell apoptosis, as well as alter cell cycle progression, whereas the contrary results could be presented in the overexpression of SNHG1. In addition, in vivo xenograft experiment also further confirmed the above results. 30087712 SNHG1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues regulation[miR-195/NEK2 Axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay The expression of lncRNA SNHG1 up-regulated while that of miR-195 down-regulated in CCCs. lncRNA SNHG1 promotes the progression of cervical cancer through the miR-195/NEK2 axis, so lncRNA SNHG1, miR-195 and NEK2 may have potential values for diagnosing and treating cervical cancer. Yes The down-regulation of lncRNA SNHG1 or the up-regulation of miR-195 led to the decrease of NEK2 and the reduction of cells' activity, migration and invasion, also resulting in the increase of cell apoptosis. 33204155 SNHG1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and CC cell lines regulation[miR-194/HCCR axis] CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay SNHG1 was highly expressed in CC tissues and CC cell lines.In vivo experiment, silencing of SNHG1 suppressed CC tumor growth by modulating miR-194/HCCR axis. Yes Knockdown of SNHG1 inhibited CC cell proliferation and enhanced the ability of cell apoptosis. 32456490 SNHG1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cervical cancer cell lines Expression [highly expressed] Transfection//Wound Healing Assay//qRT-PCR//Cell Proliferation Assay//Transwell Assay//Invasion Assay//ChIP SNHG1 was highly expressed in cervical cancer tissues and cervical cancer cell lines. After knock-down of SNHG1, cell proliferation and migration as well as invasiveness in HeLa and C-33A cells decreased. Yes After knock-down of SNHG1, cell proliferation and migration as well as invasiveness in HeLa and C-33A cells decreased. 28930646 hsa_circ_0061140 CircRNA Homo sapiens Endometriosis endometriosis tissues regulation[ modulating miR-140-3p and Notch2] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining Tissues from endometriosis women displayed an increased expression of circ_0061140.Decrease of circ_0061140 could depress endometriosis progression through modulating miR-140-3p and Notch2. Yes Then, we found loss of circ_0061140 significantly repressed ectopic endometrial cell proliferation, migration and invasion. 32621951 SNHG1 LncRNA Homo sapiens Glioma glioma tissue and cell lines Interaction[binding to miR-194 to regulate PHLDA1 expression] RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay In this study, we show that SNHG1 is overexpressed in glioma tissues and cell lines. Next, through online databases, a luciferase reporter assay and an RNA pull-down assay, we confirmed that SNHG1 functions as a sponge for miR-194, which acts as a suppressor in glioma. We also verified that pleckstrin homology like domain family A, member 1 (PHLDA1) is the functional target of miR-194. Moreover, rescue experiments demonstrated that SNHG1 regulates PHLDA1 expression in a miR-194-dependent manner. Taken together, our study shows that SNHG1 promotes glioma progression by competitively binding to miR-194 to regulate PHLDA1 expression, which may provide a novel therapeutic strategy for glioma. Yes A series of functional assays suggested that SNHG1 promotes glioma progression in vitro and in vivo. 31189920 circATRNL1 CircRNA Homo sapiens Endometriosis ectopic tissues regulation[miR-141-3p/miR-200a-3p-YAP1 axis ] qRT-PCR//Western Blot Based on the results of reverse transcription-quantitative polymerase chain reaction analysis, we found significant upregulation of circATRNL1 and Yes-associated protein 1 (YAP1), while downregulation of miR-141-3p and miR-200a-3p in ectopic tissues compared to eutopic tissues. Our findings demonstrate that abnormal upregulation of circATRNL1 regulates cell proliferation and motility and promotes EMT process via the miR-141-3p/miR-200a-3p-YAP1 axis in vitro, which could contribute to the progression of endometriosis. Yes The in vitro assays indicated that overexpression of circATRNL1 could promote the proliferation, migration, and invasion of Ishikawa cells, and induce EMT process, while circATRNL1 silencing showed the opposite effect. 32728069 SNHG1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cell Interaction(miR-186/FUT8) qRT-PCR//RIP SNHG1 was overexpressed in OSCC cells. Mechanistically, we demonstrated that SNHG1 could directly bind to miR-186 and positively regulated α1, 6-fucosyltransferase (FUT8) level. Yes SNHG1 silencing prevented cell proliferation and increased the incidence of apoptosis, DNA fragments, cleaved-caspase 3, and Bax protein levels. Cell migration and invasion were reduced after SNHG1 deletion, and MMP2 and MMP9 protein levels were decreased. SNHG1 overexpression promoted cell survival, migration, and invasion, reduced DNA fragments formation. 33872442 SNHG1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cells Interaction(miR-137-3p/EZH2) qRT-PCR//RIP SNHG1 was significantly overexpressed in BC tissues and cells. Regarding mechanism, the results of AGO2-RIP, ChIP or DLRA showed that SNHG1 played different roles at diverse subcellular sites. In the cytoplasm, SNHG1 acted as a competing endogenous RNA for miR-137-3p to promote EZH2 expression. In the nucleus, SNHG1 could interact with EZH2 to inhibit KLF2 transcription. Importantly, SNHG1 was associated with poor survival, and ROC curves revealed high diagnostic values. Yes Moreover, by CCK8, wound healing, transwell, and Western blot analysis, SNHG1 knockdown significantly inhibited the proliferation, migration, invasion, and epithelial-mesenchymal transition of BC cells. Additionally, in vivo experiments showed that silencing SNHG1 hindered tumorigenesis and tumor growth. 36087568 SNHG1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues interaction[EZH2 and miR-154-5p] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining Our analysis revealed that SNHG1 was upregulated in human colorectal cancer tissues, and high SNHG1 expression was associated with reduced patient survival. Mechanistic investigations demonstrated that SNHG1 could directly interact with Polycomb Repressive Complex 2 (PRC2) and modulate the histone methylation of promoter of Kruppel like factor 2 (KLF2) and Cyclin dependent kinase inhibitor 2B (CDKN2B) in the nucleus. Our analysis revealed that SNHG1 was upregulated in human colorectal cancer tissues, and high SNHG1 expression was associated with reduced patient survival. Yes Moreover, SNHG1 knockdown significantly repressed colorectal cancer cells growth both in vitro and in vivo. 30266084 SNHG1 LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma and corresponding adjacent non-tumor tissues,cell lines (Huh7,HepG2,L02) Interaction[sponging miR-195] qRT-PCR//MTT//Luciferase Report Assay//Western Blot Generally, a significant increase in SNHG1 expression was observed in cancer cell lines compared to normal liver cell lines (Figure 1 A, p < 0.001). Consistent with this observation, SNHG1 was significantly up-regulated in hepatocellular carcinoma tissues in comparison to the levels in adjacent non-tumor tissues (Figure 1 B, p < 0.001). SNHG1 may promote cell invasion and migration in HCC cells by sponging miR-195. Yes When transfected with si-SNHG1, migration and invasion of HCC cells, as well as expression of astrocyte elevated gene 1 (AEG-1) protein, were significantly inhibited compared with the control cells. 32190150 SNHG1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues,cell lines Interaction[miR-497/miR-195-5p] qRT-PCR//Western Blot It seemed that there was a high potential for highly expressed SNHG1 and lowly expressed miR-497/miR-195 to symbolize CRC patients' unfavorable prognosis (p < .05). Concurrently, CRC cells were detected with higher SNHG1 expression and lower miR-497/miR-195 expression than CCC-HIE-2 cells (p < .05).Intriguingly, the strength of miR-195-5p collaborating with miR-497-5p in affecting the activity of CRC cells seemed to overweigh that of miR-497/miR-195-5p alone. Besides, both miR-195-5p and miR-497-5p were subjected to in vivo and in vitro modification of SNHG1 (p < .05). Conclusively, application of lncRNA SNHG1 for treating CRC might be promising, given its dual modulation of miR-497 and miR-195 underlying CRC pathogenesis. Yes In addition, the EMT process of CRC cells was facilitated markedly against the contexts of overexpressed SNHG1 and underexpressed miR-497-5p/miR-195-5p. 31276207 SNHG1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Interaction[PI3K/AKT/mTOR pathway ] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Transwell Assay In the present study, it was demonstrated that SNHG6 expression was downregulated in colorectal cancer tissues by reverse transcription quantitative polymerase chain reaction assays.The overexpression of SNHG6 inhibited colon cell viability and proliferation by targeting ETS1 through the phosphoinositide 3‑kinase/protein kinase B/mechanistic target of rapamycin signaling pathway. These results suggested that SNHG6 may directly suppress ETS1, which may be one of potential mechanisms through which it inhibits the viability and proliferation of colorectal cancer cells, and it provides novel insight into the carcinogenesis of colorectal cancer. Yes Overexpression of SNHG6 not only inhibited the proliferation of colon cancer cells in vitro by inducing apoptosis, but also inhibited cell proliferation, invasion and migration. 31322251 SNHG1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Interaction[sponging miR-137] RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Transwell Assay SNHG1 upregulation was observed in CRC tissues and cell lines, which was associated with the lymph node metastasis, advanced TNM stage and poorer prognosis. SNHG1 regulated RICTOR expression by sponging miR-137 and promoted tumorgenesis in CRC. SNHG1 upregulation was observed in CRC tissues and cell lines, which was associated with the lymph node metastasis, advanced TNM stage and poorer prognosis. Yes In addition, SNHG1 silencing inhibited CRC cell proliferation and migration in vitro and in vivo. 31469189 SNHG1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancers tissues and cells Interaction(miR-145) qRT-PCR//Colony Formation Assay//Western Blot In this study, SNHG1 was upregulated in colorectal cancers, and SNHG1 expression was correlated with advanced colorectal cancer stage and tumor recurrence.We found that SNHG1 promoted cell proliferation by acting as a sponge of miR-145, a well known tumor suppressor of colorectal cancer. In this study, SNHG1 was upregulated in colorectal cancers, and SNHG1 expression was correlated with advanced colorectal cancer stage and tumor recurrence.Furthermore, the survival analysis indicated that colorectal cancer patients with higher expression of SNHG1 had a worse prognosis. Yes We found that SNHG1 promoted cell proliferation by acting as a sponge of miR-145, a well known tumor suppressor of colorectal cancer. 29416759 SNHG1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues and cancerous cell lines Expression[highly expressed] CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay In the present study, we referred to the Oncomine database and used RT-qPCR to determine that SNHG1 expression was significantly higher both in colon cancer tissues and cancerous cell lines than in normal samples. Yes Cell functional experiments were performed after knockdown of SNHG1, including Cell Counting Kit-8 assay, colony formation assay, Transwell? assay, and flow cytometric analyses of cell apoptosis, which suggested that SNHG1 stimulated colon cancer cell proliferation, promoted cell invasion and migration, and inhibited apoptosis. 29749530 SNHG1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and RCC cell lines Regulation[miR-137] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay SNHG1 was identified to be overexpressed in RCC tissues and RCC cell lines.Overexpression of SNHG1 participates in RCC tumorigenesis by regulating miR-137. High levels of SNHG1 were correlated with poor prognosis of RCC patients. Yes Knockdown of SNHG1 suppressed the proliferation, invasion, and EMT capacity in RCC. 29874202 SNHG1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells Interaction(mmiR-129-3p/ STAT3 and PD-L1) Wound Healing Assay//Transwell Assay//Western Blot Quantitative real-time PCR and western blotting results revealed that the expression of lncRNA SNHG1 and STAT3 were upregulated in RCC tissues and cells and that the expression of miR-129-3p was downregulated. Yes SNHG1 knockdown or miR-129-3p overexpression inhibited the proliferation and invasion of A498 and 786-O cells, while the proliferation and cytotoxicity of CD8+ T cells increased, which promoted the secretion of immune-related factors. 33739543 SNHG1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines Interaction(miR-103a) CCK8//qRT-PCR The expression of SNHG1 markedly increased in RCC tissues and cell lines. Subsequent studies identified SNHG1 as a miRNA sponge for miR-103a. In addition, SNHG1 knockdown and miR-103a overexpression significantly inhibited progression of RCC. miR-103a also regulated HMGA2 levels. Yes Subsequent studies identified SNHG1 as a miRNA sponge for miR-103a. In addition, SNHG1 knockdown and miR-103a overexpression significantly inhibited progression of RCC. miR-103a also regulated HMGA2 levels. 35466471 SNHG1 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Interaction[sponging miR-195-5p] CCK8//qRT-PCR//Transwell Assay Our results indicated a high expression of SNHG1 in hepatocellular carcinoma cells. Moreover, the expression of programmed cell death 4 (PDCD4) was positively regulated by SNHG1 through competing with miR-195-5p. These results indicated that SNHG1 participated in the development of hepatocellular carcinoma as a ceRNA to competitively bind to miR-195-5p and thus mediate PDCD4 expression. Yes Downregulation of SNHG1 inhibited proliferative and migratory potentials of hepatocellular carcinoma cells in vitro and in vivo. 31330233 SNHG1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer cells and tumor tissues Interaction(miR-493-5p/ATG14/autophagy pathway) qRT-PCR//MTT The findings showed high expression of SNHG1 in the bladder cancer cells and tumor tissues. Further analysis of the mechanism of action of SNHG1 showed that it functions as a sponge of miRNA-493 in bladder cancer. miRNA-493 binds on the 3' -UTR of ATG14 mRNA thus affecting ATG14 protein expression, which is implicated in autophagy. Yes This finding implies that SNHG1 promotes bladder cancer cell invasion and proliferation via autophagy. 34055628 SNHG1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[CDKN1A and CDKN2B] RNA Pull-Down//Flow Cytometry//qRT-PCR//RIP//FISH//Luciferase Report Assay SNHG1 was upregulated in HCC tissues and cells, and its knockdown significantly inhibited HCC cell cycle, growth, metastasis, and epithelial-mesenchymal transition (EMT) both in vitro and in vivo. Chromatin immunoprecipitation and RNA immunoprecipitation assays demonstrate that SNHG1 inhibit the transcription of CDKN1A and CDKN2B through enhancing EZH2 mediated-H3K27me3 in the promoter of CDKN1A and CDKN2B, thus resulting in the de-repression of the cell cycle. Yes SNHG1 was upregulated in HCC tissues and cells, and its knockdown significantly inhibited HCC cell cycle, growth, metastasis, and epithelial-mesenchymal transition (EMT) both in vitro and in vivo. 33009370 SNHG1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells interaction[sponging miR-377-3p] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT We found that SNHG1 was markedly upregulated in HCC tissues and cells. In conclusion, SNHG1 inhibited apoptosis and induced proliferation, migration, invasion, and EMT by sponging miR-377-3p in HCC, which indicated that SNHG1 may be a potential biomarker and therapeutic target for HCC treatment. Yes Knockdown of SNHG1 induced apoptosis and inhibited proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) of HCC cells. SNHG1 knockdown suppressed the tumor growth of HCC in vivo. 32122143 SNHG1 LncRNA Homo sapiens Carcinoma, Hepatocellular clinical HCC tissues of 75 patients with HCC Interaction( miR-376a/FOXK1/Snail axis ) qRT-PCR//Luciferase Report Assay//FISH SNHG1 and FOXK1 were upregulated, and miR-376a was downregulated in HCC. SNHG1 could competitively bind to miR-376a to upregulate its target gene FOXK1, which upregulated Snail. SNHG1 knockdown delayed cancer progression both in vitro and in vivo by upregulating miR-376a and downregulating FOXK1 and Snail. Yes SNHG1 knockdown contributed to suppression of HCC cell viability, invasion, and migration properties and promotion of apoptosis. SNHG1 knockdown exerts anti-tumor activity in HCC, suggesting a therapeutic target. 34095464 SNHG1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-326/LMNB2 ) qRT-PCR//Wound Healing Assay//Western Blot Our results showed that SNHG1 expression was upregulated significantly in HCC tissues and cell lines. Furthermore, SNHG1 could regulate LMNB2 expression through binding to miR-326 in HCC cell lines. Yes Downregulation of both LMNB2, the target of miR-326 in HCC, and SNHG1 inhibited tumor proliferation and growth in vitro and in vivo. 34917510 SNHG1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC patients Expression(highly expressed) qRT-PCR We found that SNHG1 was overexpressed and often amplified in HCC patients. In the SNHG1-associated network, high expression levels of SNHG1 (log-rank P value = 0.0643), E2F8 (log-rank P value = 0.000048), FANCE (log-rank P value = 0.00125) and LMNB2 (log-rank P value = 0.0392) were significantly associated with poor survival. Yes In addition, SNHG1 upregulation was associated with the promotion of several primary biological functions, including cell proliferation, transcription and protein binding. 33499863 SNHG1 LncRNA Homo sapiens Ovarian Neoplasms 30 OC Tumor tissues and neighboring healthy tissues Interaction(miR-454 and ZEB1) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//H&E Staining//Invasion Assay We found that SNHG1 is overexpressed in OC. Downregulation of SNHG1 promoted miR-454 expression and reduced ZEB1 levels. Moreover, SNHG1 increased ZEB1 expression by downregulating miR-454 and activated Akt signaling, thereby promoting epithelial-mesenchymal transition and enhancing the invasiveness of OC cells. Yes In addition, knockdown of SNHG1, also reduced the aggressiveness of A2780 and SK-OV3 cells. Furthermore, SNHG1 downregulation by siRNA hindered cell migration and invasion; however, this effect was reversed by co-transfection of miR-454 into A2780 and SK-OV3 cells. Tumor xenograft analyses confirmed that SNHG1 affects OC proliferation and metastasis in vivo. 33641229 SNHG1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues regulation[PI3K/AKT signaling pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay It was demonstrated that SNHG1 expression was significantly upregulated in bladder cancer tissues and cells.Therefore, it was speculated that SNHG1 functioned as a carcinogenic lncRNA in bladder cancer via activation of PI3K/AKT. Yes Moreover, the loss-of-function experimental results suggested that knockdown of SNHG1 inhibited bladder cancer cell proliferation, migration and invasion, but increased apoptosis; however, SNHG1 overexpression promoted these processes. 32989389 SNHG1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cells interaction[ miR-143-3p and EZH2] RNA Pull-Down//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining//ChIP In the present study, SNHG1 was found to be substantially up-regulated in BC tissues and cells and was intimately correlated with the TNM stage, lymphatic invasion, metastasis and recurrence-free survival in BC patients.In the nucleus, SNHG1 could interact with EZH2 and regulate the histone methylation of the CDH1 promoter, altering the biological behaviours of BC cells. In the present study, SNHG1 was found to be substantially up-regulated in BC tissues and cells and was intimately correlated with the TNM stage, lymphatic invasion, metastasis and recurrence-free survival in BC patients. Yes Down-regulation of SNHG1 dramatically attenuated the proliferation, migration and invasion of BC cells, whereas the ectopic overexpression of SNHG1 had the opposite effects in vitro. The in vivo experimental results also indicated that SNHG1 down-regulation hampered the tumour growth and metastasis of BC cells. 32885590 SNHG12 LncRNA Homo sapiens Endometrial Neoplasms EC cell lines interaction[SNHG12/miR-4429 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay SNHG12 was overexpressed in EC cell lines with decreased expression of miR?4429.Therefore, targeting the SNHG12/miR‑4429 axis could serve as a potential future therapeutic target for treatment of EC. Yes Further experiments demonstrated that SNHG12 silencing and overexpression of miR?4429 markedly suppressed proliferation, migration and invasion of RL95?2 cells, arrested cells in the G1 phase, and markedly downregulated the expression of MMP2 and MMP9. 32945395 SNHG12 LncRNA Homo sapiens Melanoma melanoma cell lines Interaction(miR-199b) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Overexpression of SNHG12 was found in melanoma cell lines, and SNHG12 promoted the proliferation, migration, and invasion of melanoma cells. MiR-199b is a target gene of SNHG12, which was expressed at low levels in melanoma cell lines, and SNHG12 regulated melanoma cell proliferation, migration, and invasion through miR-199b. We also revealed that SNHG12 promoted the expression of the target genes of miR-199b, namely ETS1, PXN, JAG1, and DDR1. Yes Overexpression of SNHG12 was found in melanoma cell lines, and SNHG12 promoted the proliferation, migration, and invasion of melanoma cells. 35280401 SNHG12 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cell lines Interaction[Sponging miR-129-5p] qRT-PCR//Luciferase Report Assay//RIP MRNA microarray and quantitative real-time PCR revealed that SNHG12 was overexpressed in the ccRCC tissues and cell lines. Mechanistically, dual luciferase assay and RNA immunoprecipitation (RIP) assay showed that miR-129-5p could bind to SNHG12 directly. There was a negative relationship between SNHG12 and miR-129-5p. What's more, we used bioinformatics-based prediction software to predict the target genes of miR-129-5p. Through data analysis and experimental verification, we found MDM4, a regulatory factor in p53 pathway, was involved in this ceRNA network. Our findings demonstrated that SNHG12 served as a sponge for miR-129-5p to regulate the expression of MDM4 and p53 pathway in the development of ccRCC. Yes Functional inhibition of SNHG12 suppressed the viability and mobility of ccRCC cells. 31824846 SNHG14 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[PABPC1] CCK8//qRT-PCR//ChIP SNHG14 was highly expressed in HCC tissues and cells, which promoted cell proliferation, migration, and angiogenesis in Hep3B and HepG2 cells. SNHG14 promoted cell proliferation and angiogenesis via upregulating PABPC1 through H3K27 acetylation and modulating PTEN signaling in the tumorigenesis of HCC. Yes SNHG14 was highly expressed in HCC tissues and cells, which promoted cell proliferation, migration, and angiogenesis in Hep3B and HepG2 cells. 32811821 Snhg15 LncRNA Mus musculus Hypoxia-Ischemia, Brain brain tissues of mice Interaction(miR-153-3p/SETD7 axis) Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//H&E Staining Results showed that SNHG15 was elevated in brain tissues of mice with HI brain injury, and knockdown of SNHG15 attenuated HI-induced impairment of neurobehavioral function, brain edema, brain injury, and cell apoptosis. Besides, SNHG15 acted as a miR-153-3p sponge. SETD7 was identified to be a target of miR-153-3p. Furthermore, down-regulation of SNHG15 inhibited the OGD-induced increase in SETD7 expression in PC12 cells. Moreover, SNHG15 modulated OGD-induced cell apoptosis and decrease of cell viability through the miR-153-3p/SETD7 axis. Yes Results showed that SNHG15 was elevated in brain tissues of mice with HI brain injury, and knockdown of SNHG15 attenuated HI-induced impairment of neurobehavioral function, brain edema, brain injury, and cell apoptosis. 35791576 SNHG14 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-543) Western Blot//Bioinformatics Analysis//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Invasion Assay//Transwell Assay Our data indicated that SNHG14 expression was increased in BC tissues and cells, and SNHG14 knockdown mitigated the proliferation, migration, and invasion and facilitated apoptosis of BC cells. SNHG14 directly interacted with miR-543. MiR-543 mediated the regulatory effects of SNHG14 silencing on BC cell behaviors. Moreover, KLF7 was a direct target of miR-543. Overexpressed miR-543-mediated anti-proliferation, anti-migration, anti-invasion, and pro-apoptosis effects were mediated by KLF7. Furthermore, SNHG14 modulated KFL7 expression through acting as a competing endogenous RNA (ceRNA) of miR-543 in BC cells. Yes SNHG14 knockdown mitigated the proliferation, migration, and invasion and facilitated apoptosis of BC cells. 34783894 SNHG14 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and corresponding noncancerous tissues,cell lines(A549, NCI-H1975, NCI-H1299, SK-MES-1) Interaction[miR-340] CCK8//qRT-PCR//Luciferase Report Assay "The results showed that SNHG14 expression was significantly higher in cancer tissues compared with that in matched noncancerous tissues (Figure 1A).We next examined the expression of SNHG14 in a number of NSCLC cell lines, and observed that increased SNHG14 expression could be observed in all four NSCLC cell lines, compared with normal 16HBE cells (Figure 1C). " As exhibited in Table 1, the high expression of SNHG14 in NSCLC was closely associated with larger tumor size (P=0.047) and advanced TNM stage (P=0.046). Kaplan–Meier analysis indicated that the prognosis was more unfavorable in NSCLC patients with high SNHG14 expression than those with low expression (P=0.04; Figure 1B). Yes KnockExpression[down-expression] of SNHG14 inhibited NSCLC cell proliferation through inducing cell cycle arrest and apoptosis, whereas SNHG14 overexpression exerted the opposite effects. Animal experiment further revealed that Expression[down-expression]-regulated SNHG14 greatly inhibited NSCLC tumor growth in vivo Further studies demonstrated that SNHG14 might serve as a competing endogenous RNA (ceRNA) by sponging miR-340 in NSCLC cells. 30254102 SNHG14 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells interaction[Sponging miR-382-5p] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The levels of SNHG14 and SPIN1 were significantly increased, while the level of miR-382-5p was apparently reduced in NSCLC tissues and cells.SNHG14 facilitated NSCLC progression by regulating SPIN1 expression via targeting miR-382-5p. Yes SNHG14 depletion repressed cell viability, migration and invasion, but induced the apoptotic rate by targeting miR-382-5p. 33061605 SNHG14 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue regulation[miR-206/G6PD pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found a higher expression of SNHG14 in NSCLC and upregulation of SNHG14 contributed to NSCLC cell proliferation, invasion and migration.LncRNA SNHG14 contributed to NSCLC progression through miR-206/G6PD axis, providing novel clues for understanding the mechanism of NSCLC. We found a higher expression of SNHG14 in NSCLC and upregulation of SNHG14 contributed to NSCLC cell proliferation, invasion and migration. Yes knockdown of SNHG14 showed the opposite effect on the progression of NSCLC. 32153123 SNHG14 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[targeting miR-92b-3p] qRT-PCR From the quantitative reverse transcription-polymerase chain reaction results, SNHG14 was found to be downregulated in CRC tissues compared with the normal mucous samples, and its low expression was significantly correlated with poor clinical outcomes.Consequently, SNHG14 exhibited low expression in CRC tissues and involved in CRC progression and metastasis by competing for miR-92b-3p, and SNHG14 could be used as a valuable biomarker and therapeutic target for CRC. From the quantitative reverse transcription-polymerase chain reaction results, SNHG14 was found to be downregulated in CRC tissues compared with the normal mucous samples, and its low expression was significantly correlated with poor clinical outcomes. Yes Overexpression of SNHG14 inhibited cell growth, induced cell apoptosis, suppressed migration and invasion by inhibiting epithelial-mesenchymal transition process. 31692034 SNHG14 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-519b-3p/DDX5 axis) CCK8//qRT-PCR//Tunel//Western Blot In our study, we found that SNHG14 is highly expressed in CRC tissues and cells, especially in SW480 and HT-29 cells.Furthermore, we found that SNHG14 functions as a sponge for miR-519b-3p, while the DEAD box protein 5 (DDX5) is a downstream target gene of miR-519b-3p, and the functions of miR-519b-3p inhibitors on the CRC progression could be rescued by downregulation of DDX5. Yes In addition, sh-SNHG14 inhibits cell proliferation, cell migration and invasion, promotes cell apoptosis in CRC cell lines. 34234865 SNHG14 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Interaction[miR-4673/SOCS1] CCK8//Luciferase Report Assay//Colony Formation Assay//Flow Cytometry SNHG14 was found highly expressed in HCC cells and tissues. Dual-Luciferase reporter assays confirmed miR-4673 could bind with SNHG14 and SOCS1. In addition, we showed overexpression of miR-4673 or knockdown of SOCS1 could partially reverse the effects of SNHG14 overexpression on HCC cells. SNHG14 was revealed could promote HCC cell proliferation, colony formation but inhibit cell apoptosis by sponging miR-4673 to regulate SOCS1 expression. Yes In addition, we found SNHG14 overexpression could accelerate HCC cell proliferation and colony formation bur inhibit cell apoptosis. On the contrary, knockdown of SNHG14 could cause the exactly opposite effects on HCC cells. 31632558 SNHG14 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues interaction[Sponging miR-217] qRT-PCR//Luciferase Report Assay//Western Blot The upregulation of lncRNA-SNHG14 was observed in HCC tissues compared with normal tissues via RT-qPCR and bioinformatic analysis of TCGA data.In summary, SNHG14 is involved in the development of HCC via sponging miR-217 and it may be a biomarker for patients with HCC. Yes Silencing of SNHG14 inhibited cell proliferation and induced cell apoptosis in HCC cells. 32581548 SNHG15 LncRNA Homo sapiens Breast Neoplasms breast cancer cells Interaction(miR-345-5p) In Vivo Experiment//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay This present study revealed that the expression of lncRNA SNHG15 (lnc-SNHG15) was significantly upregulated in breast cancer cells, and its overexpression was associated with the tumor. The relative expression of lnc-SNHG15 could be downregulated using siRNAs, and silencing lnc-SNHG15 inhibited the proliferation and the migration of MDA-MB-231 cells. In vivo experiments using the zebrafish xenograft model showed similar results. Mechanistically, the knockdown effect of lnc-SNHG15 could be restored by inhibiting the expression of the miR-345-5p, confirming the negative regulation between lnc-SNHG15 and miR-345-5p. Interestingly, cisplatin treatment combined with SNHG15 knockdown effectively inhibited MDA-MB-231 cell proliferation and migration in the zebrafish xenograft compared to negative controls. Yes In vivo experiments using the zebrafish xenograft model showed similar results. Mechanistically, the knockdown effect of lnc-SNHG15 could be restored by inhibiting the expression of the miR-345-5p, confirming the negative regulation between lnc-SNHG15 and miR-345-5p. 36467335 SNHG14 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues Interaction(miR-206/SOX9) qRT-PCR SNHG14 and SOX9 were up-regulated in HCC tumor tissues compared with adjacent normal tissues, with decreased miR-206 expression. Besides, inverse correlations between SNHG14 and miR-206, as well as between miR-206 and SOX9, were noted. The dual luciferase reporter gene assay, RIP, and RNA pull-down experiments also revealed the targeting relationship between SNHG14 and miR-206 or between miR-206 and SOX9. Moreover, SNHG14 expression was significantly associated with the TNM stage, lymphatic metastasis, and histological differentiation of HCC patients. Yes Silencing SNHG14 and SOX9 inhibited the proliferation, invasion, and migration of HCC cells, with increased apoptosis, which was all abolished by silencing miR-206. 33782806 SNHG14 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-876-5p/SSR2 axis) qRT-PCR we demonstrated that SNHG14 was highly expressed in HCC tissues, meanwhile, the elevated expression of SNHG14 predicted poor prognosis in patients with HCC. SNHG14 promoted proliferation and metastasis of HCC cells. We further revealed that SNHG14 functioned as a competing endogenous RNA (ceRNA) for miR-876-5p and that SSR2 was a downstream target of miR-876-5p in HCC. Transwell, CCK8 and animal experiments exhibited miR-876-5p inhibited HCC progression in vitro and in vivo. By conducting rescue experiments, we found the overexpression of SSR2 or knocking down the level of miR-876-5p could reverse the suppressive roles of SNHG14 depletion in HCC we demonstrated that SNHG14 was highly expressed in HCC tissues, meanwhile, the elevated expression of SNHG14 predicted poor prognosis in patients with HCC. Yes By conducting rescue experiments, we found the overexpression of SSR2 or knocking down the level of miR-876-5p could reverse the suppressive roles of SNHG14 depletion in HCC 33485374 SNHG14 LncRNA Homo sapiens Ovarian Neoplasms ovarian tissues Interaction[upregulating DGCR8] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay SNHG14 level was dramatically higher in ovarian cancer specimens. In summary, SNHG14 could enhance cell migration and invasion via upregulating DGCR8 in ovarian cancer. Yes Moreover, cell migration and invasion were significantly attenuated via the inhibition of SNHG14, while enhanced via the SNHG14 overexpression. 31841176 SNHG14 LncRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cell lines Interaction[targeting miRNA-150-5p] CCK8//qRT-PCR//Luciferase Report Assay//Flow Cytometry SNHG14 was highly expressed in BCa tissues and cell lines. LncSNHG14 overexpression accelerates proliferative potential and cell cycle progression of BCa cells through absorbing miRNA-150-5p to degrade VAMP2 expression. Yes overexpression of SNHG14 accelerated the proliferative potential and cell cycle progression of BCa cells. 30779068 SNHG14 LncRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cells Interaction(microRNA-211-3p/ESM1 axis) qRT-PCR//MTT Enhanced SNHG14, ESM1 and suppressed miR-211-3p were found in BCa tissues and cells.SNHG14 up-regulated ESM1 via competitive binding with miR-211-3p. miR-211-3p inhibition or ESM1 overexpression reversed the effects of down-regulation of SNHG14 on BCa, and miR-211-3p up-regulation or ESM1 downregulation reversed the effect of SNHG14 overexpression on BCa. SNHG14 targeted miR-211-3p to regulate ESM1 expression. Yes Decreased SNHG14 or up-regulated miR-211-3p depressed cell cycle entry, colony formation, invasion, migration and proliferation abilities, and facilitated apoptosis of BCa cells. Decreased SNHG14 or up-regulated miR-211-3p reduced the tumor volume and weight of nude mice with BCa, as well as promoted apoptosis and restrained proliferation of tumor cells. 33482820 SNHG14 LncRNA Homo sapiens Endometrial Neoplasms EC tissues regulation[miR-93-5p/ ZBTB7A Axis] RNA Pull-Down//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay SNHG14 was underexpressed in EC.LncRNA SNHG14 hampered the viability, migration and invasion of EC cells via modulating miR-93-5p/ZBTB7A axis. NHG14 expression was significantly relevant to menstruation, FIGO stage, histological grade and lymphatic metastasis of EC patients. Yes SNHG14 overexpression hampered viability, migration and invasion of EC cells. 33061638 SNHG14 LncRNA Homo sapiens Parkinson Disease SK-N-SH cells Interaction(miR-135b-5p/KPNA4 axis) qRT-PCR//RIP//Western Blot MPP+ treatment elevated the expression of SNHG14 in SK-N-SH cells in a dose and time-dependent manner. SNHG14 interacted with miR-135b-5p, and SNHG14 silencing-mediated effects were partly overturned by miR-135b-5p knockdown in PD cell model. Besides, miR-135b-5p interacted with the 3' untranslated region (3'UTR) of KPNA4, and KPNA4 overexpression partly reversed miR-135b-5p overexpression-induced effects in PD cell model. SNHG14 knockdown reduced the protein level of KPNA4 partly by up-regulating miR-135b-5p in SK-N-SH cells. Yes SNHG14 knockdown alleviated MPP+-induced apoptosis, inflammation, and cytotoxicity in SK-N-SH cells. 35781593 SNHG14 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissue interaction[EZH2] CCK8//qRT-PCR//Western Blot//Transwell Assay In the study, we found that SNHG14 expression was higher in PDAC tissue compared to adjacent normal tissues by qRT-PCR analysis.Upregulation of SNHG14 expression promoted cell invasion by affecting E-cadherin expression via interacting with EZH2. Higher SNHG14 expression was significantly associated with advanced TNM stage and positive lymph node metastasis in PDAC patients. Yes Moreover, we showed that higher SNHG14 expression promoted cell proliferation, cell colony formation and cell invasion ability in PDAC. 31929143 Snhg15 LncRNA Mus musculus Reperfusion Injury infarcted area tissues of I/R mice and I/R-stimulated AC16 cells Interaction(miR-335-3p/TLR4/NF-κB Pathway) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining SNHG15 was overexpressed in the infarcted area tissues of I/R mice and I/R-stimulated AC16 cells. Mechanistically, SNHG15 directly targeted miR-335-3p, and miR-335-3p was a functional mediator of SNHG15. MiR-335-3p inhibited TLR4 expression by targeting TLR4, and miR-335-3p-mediated inhibition of TLR4 alleviated I/R-induced injury in AC16 cells. Moreover, SNHG15 regulated the TLR4/nuclear factor-κB (NF-κB) signaling pathway through miR-335-3p. Yes SNHG15 knockdown alleviated I/R injury in AC16 cells. 35650158 circSirt1 CircRNA Homo sapiens Arthritis, Rheumatoid RA-FLS MH7A cell line Regulation Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//ELISA//Colony Formation Assay This study showed circ-Sirt1 inhibited the proliferation and induced apoptosis of MH7A cells. Yes Overexpression of circ-Sirt1 decreased of the levels of interleukin (IL)-1β and IL-6, tumour necrosis factor (TNF)-α, and matrix matalloproteinases (MMP)-1 and MMP-3 in MH7A cells. In addition, overexpression of circ-Sirt1 increased the expression of Sirt1, Nrf2, HO-1, IκBα, GCLC and GCLM, and decreased the ratio of acetylated NF-κB to normal NF-κB, and the expression of AP-1, COX-2 and HMGB1. 34431434 SNHG12 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues regulation[AKT pathway ] Flow Cytometry//MTT//Colony Formation Assay//Transwell Assay We found that the expression of SNHG12 in PCa tissues was significantly higher than that in matched normal adjacent tissues (P < 0.05) (Figure 1(a)). We found that SNHG12 was significantly upregulated in the DU145 cell line compared with the normal human prostate stromal cell line (WPMY-1) and the other two human prostate carcinoma cell lines, LNCAP and PC-3 (Figure 1(b)). Our results indicated that the AKT pathway was positively regulated by SNHG12, as found in studies of renal cell carcinoma [30]. Yes We found that SNHG12 promoted cell proliferation and suppressed apoptosis in PCa cells, which suggests that SNHG12 is probably a novel PCa biomarker and therapy target of PCa. 33426070 circPTTG1IP CircRNA Homo sapiens Arthritis, Rheumatoid RA patients and RA-FLSs Interaction( miR-671-5p/TLR4 axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//ELISA//Transwell Assay The results uncovered that circ-PTTG1IP was overexpressed in RA patients and RA-FLSs, and circ-PTTG1IP knockdown suppressed cell proliferation, migration, invasion and inflammatory response in RA-FLSs. Thus, circ-PTTG1IP knockdown repressed cell proliferation, migration, invasion and inflammatory response in RA-FLSs by regulating the miR-671-5p/TLR4 axis. Yes The results uncovered that circ-PTTG1IP was overexpressed in RA patients and RA-FLSs, and circ-PTTG1IP knockdown suppressed cell proliferation, migration, invasion and inflammatory response in RA-FLSs. 34100377 circFBXW7 CircRNA Homo sapiens Arthritis, Rheumatoid RA-FLSs and RA model Interaction(miR-216a-3p/HDAC4) RNA Pull-Down//Western Blot//Transfection//FISH//qRT-PCR//Luciferase Report Assay CircFBXW7 could directly sponge miR-216a-3p to upregulate the expression of HDAC4. Inhibition of HDAC4 or upregulation of miR-216a-3p abolished the therapeutic function of exosomal circFBXW7. Yes Exosomal circFBXW7 treatment suppressed proliferation, migration and inflammatory response of RA-FLSs and damage of RA model. 34853524 SNHG15 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissue Interaction[sponging miR-141-3p] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Invasion Assay SNHG15 expression was markedly increased, whereas miR-141-3p expression was substantially reduced in HCC cells and tissue samples relative to normal controls. These finding suggested that SNHG15 promoted HCC progression via negative regulation of miR-141-3p, thus identifying a potential novel HCC treatment pathway. Yes When SNHG15 was knocked down, this resulted in a significant disruption to the proliferation, as well as the invasive and migratory ability of these HCC cells. 31310393 SNHG15 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Regulation[miR-490-3p/ histone deacetylase 2 axis ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our research showed that up-regulation of SNHG15 was found in HCC and was related to aggressive behaviors in HCC patients.In conclusion, long noncoding RNA SNHG15 promotes HCC progression by mediating the miR-490-3p/HDAC2 axis in HCC. Yes Moreover, knockdown of SNHG15 restrained HCC cell proliferation, migration and invasion. 31636472 SNHG15 LncRNA Homo sapiens Ovarian Neoplasms ovarian tissues and cells regulation[SNHG15/miR-18a-5p axis] qRT-PCR We found that the messenger RNA expression level of SNHG15 was significantly higher and miR-18 was decreased in ovarian cancer tissues and in OC cells. SNHG15/miR-18a promoted the progression of OC cells via the protein kinase B/mammalian target of rapamycin signaling pathway. Yes Functional experiments showed that SNHG15 overexpression potentiated the migration and invasion of OC cells, while SNHG15 inhibition reduced the tumor proliferation, which was restored via overexpression of miR-18a. 33135285 SNHG15 LncRNA Homo sapiens Ovarian Neoplasms tumor tissues and the cell line Interaction(miR-370-3p/CDK6) qRT-PCR//Western Blot SNHG15 was initially identified by using GEO datasets (GSE135886 and GSE119054) and validated by tumor tissues and the cell line, identifying that SNHG15 was upregulated in ovarian cancer. Mechanistically, SNHG15 promotes proliferation through upregulated CDK6 via sponging miR-370-3p. Besides, high SNHG15 indicated poor prognosis in ovarian cancer. Yes Furthermore, knockdown SNHG15 suppresses ovarian cancer proliferation and promotes apoptosis. 34734088 SNHG15 LncRNA Homo sapiens Urinary Bladder Neoplasms 5637, UMUC3 and T24 cell lines Expression(highly expressed) CCK8//qRT-PCR The expression of lncRNA-SNHG15 was up regulated in 5637, UMUC3 and T24 cell lines compared with corresponding normal controls (P < 0.05). Up regulation was positively related to tumor stage (P = 0.015). And tumor size (P = 0.0465). Up regulation was positively related to tumor stage (P = 0.015). And tumor size (P = 0.0465). Yes The down-regulation of lncRNA-SNHG15 with siRNA significantly inhibited UMUC3 and T24 cell proliferation and invasion. 34016097 SNHG15 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Human OSCC cell lines (SCC-15, SCC-9, SCC-25, and HSC-2) Interaction(miR-188-5p/DAAM1) qRT-PCR//Luciferase Report Assay//RIP SNHG15 presented a high expression in OSCC cells. Through the search of bioinformatics and RNA pull down assays, we confirmed that miR-188-5p was one target of SNHG15 in OSCC cells. Additionally, miR-188-5p could hamper the growth of OSCC cells. Moreover, it was manifested that DAAM1 was down-regulated by miR-188-5p. Yes Moreover, inhibition of SNHG15 exhibited repressive influence on proliferative, migrated, and invasive abilities but induce apoptosis of OSCC cells. 33742497 SNHG15 LncRNA Homo sapiens Osteosarcoma OS tissues regulation[miR-346/TRAF4 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expression of SNHG15 and TRAF4 was promoted in OS tissues opposite for that of miR-346. Yes The silencing of SNHG15 limited the proliferation, invasion, and enhanced apoptosis of SaoS2 and HOS cells. 33817231 SNHG15 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tumor tissues and cells Interaction(miR-4735-3p/HIF1a Pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//ChIP Using qRT-PCR, we determined that lncRNA SNHG15 is highly expressed in CC tumor tissues and cells. Using bioinformatics analysis, RNA pull-down, ChIP, and luciferase reporter assays, we verified the molecular mechanisms of lncRNA SNHG15 in CC progression and found that lncRNA SNHG15 expression in CC cells is transcriptionally regulated by SOX12; moreover, lncRNA SNHG15 promotes CC progression via the miR-4735-3p/HIF1a axis. Yes lncRNA SNHG15 knockdown also reduces the tumorigenic properties of CC in vitro, as determined using the MTT, EdU, flow cytometry, and transwell assays. 35069980 hsa_circ_0088194 CircRNA Homo sapiens Arthritis, Rheumatoid RA fibroblast-like synoviocytes Interaction(miR-766-3p/MMP2 Axis) Western Blot//Transfection//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Invasion Assay In the present study, we identified a novel circRNA, Circ_0088194, which was upregulated in RA fibroblast-like synoviocytes (RA-FLSs) and correlated with the disease activity score in 28 joints. Mechanistically, Circ_0088194 acted as a miR-766-3p sponge to relieve the repressive effect of miR-766-3p on its target, MMP2 (encoding matrix metalloproteinase 2), thereby promoting migration and invasion. Collectively, this study identified a novel circRNA Circ_0088194 that promotes RA-FLS invasion and migration via the miR-766-3p/MMP2 axis. Yes Overexpression of Circ_0088194 promoted RA-FLS migration and invasion, while inhibition of Circ_0088194 had the opposite effect. 33692802 SNHG15 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells regulation[miR-141-3p,KLF9] qRT-PCR//Luciferase Report Assay//Western Blot SNHG15 was upregulated in NPC tissues and cells. SNHG15 is upregulated in NPC tissues, and this aggravates the progression of NPC by absorbing miR-141-3p to upregulate KLF9. High level of SNHG15 indicated worse survival in NPC patients. Yes Knockdown of SNHG15 markedly suppressed proliferative ability and induced apoptosis in SUNE1 and CNE1 cells. 32633365 SNHG15 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues and cell lines Expression[lower expressed] qRT-PCR In results, SNHG15 expression was downregulated in thyroid cancer tissues and cells In results, SNHG15 expression was downregulated in thyroid cancer tissues and cells, and correlated with age, pathology classification, clinical stage, tumor size, distant metastasis, and disease-free survival. Yes The in vitro studies suggested SNHG15 overexpression suppressed cell proliferation, migration, and invasion in thyroid cancer. 30623483 SNHG15 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells. Interaction(microRNA-345-5p/RAB27B axis) In Vivo Experiment//Transfection//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay The relative expression level of lncRNA SNHG15 and RAB27B was elevated, but that of miR-345-5p was decreased in PC. miR-345-5p was the target gene of SNHG15 and suppressed cell proliferation, migration and invasion in PC. Furthermore, miR-345-5p targeted RAB27B. Yes Silencing of SNHG15 suppressed the proliferation, invasion and migration of PC cells in vitro and suppressed tumour growth in xenograft mice in vivo. 34594410 SNHG15 LncRNA Homo sapiens Prostatic Neoplasms cell lines Regulation[regulating miR-338-3p/FKBP1A axis] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Using qRT-PCR analysis, we identified the upregulation of SNHG15 in PCa cell lines. Finally, the involvement of miR-338-3p and FKBP1A in SNHG15-mediated biological function was demonstrated by performing rescue assays. In summary, our study revealed the function of a novel pathway in PCa. Yes Loss-of function assays were conducted to determine the regulatory effect of SNHG15 on PCa cell proliferation, migration and epithelial-mesenchymal transition (EMT). 30981837 SNHG15 LncRNA Homo sapiens Liver Neoplasms liver cancer tissues and cells regulation[microRNA-18b-5p/LIM-only 4 axis] qRT-PCR SNHG15 and LMO4 were overexpressed while miR-18b-5p was downregulated in liver cancer tissues and cells. The work has illuminated that silencing SNHG15 represses liver cancer progression by modulating miR-18b-5p and LMO4, indicating the therapeutic potency of SNHG15/miR-18b-5p/LMO4 axis in liver cancer. Up-regulated SNHG15 was connected with inferior prognosis and aggressive behaviors of liver cancer patients. Yes SNHG15 knockdown or miR-18b-5p restoration depressed SMMC-7721 cell growth in vivo and in vitro. 33372376 SNHG15 LncRNA Homo sapiens Diabetic Nephropathies pediatric DN tissues and HG-induced HGMCs Interaction(miR-141/ICAM-1 axis in vitro) qRT-PCR//ELISA//MTT//Western Blot The results showed that SNHG15 was remarkably up-regulated in pediatric DN tissues and HG-induced HGMCs. SNHG15 was identified to be a lncRNA that could bind to miR-141, and ICAM-1 was a downstream target gene of miR-141. Both the low expression of miR-141 and high expression of ICAM-1 reversed the inhibiting effect of SNHG15 knockdown on inflammatory response, and the promoting effect on cell viability. T Yes Functional experiments indicated that both silencing of SNHG15 and overexpression of miR-141 elevated the cell viability, and suppressed the inflammation in HG-induced HGMCs. 33506255 SNHG15 LncRNA Homo sapiens Ischemic Stroke nerve cells Interaction(miR-141/SIRT1 Axis) Western Blot//Transfection//qPCR//Luciferase Report Assay//Bioinformatics Analysis SNHG15 expression increased during the process of oxygen-glucose-deprived reoxygenation, and the oxidative stress process was reduced by miR-141/SIRT1. Yes In the SNHG15-siRNA-transfected oxygen-glucose-deprived reoxygenation cell model group, miR-141 expression increased, SIRT1 expression decreased, and the expressions of p65, TNF-α, and IL-6 increased compared with the si-NC group. In the miR-141-mimic-transfected oxygen-glucose-deprived reoxygenation cell model, SNHG15 expression decreased, SIRT1 expression decreased, and the expressions of p65, TNF-α, IL-1β, and IL-6 increased. 34868528 SNHG14 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//Flow Cytometry//EdU Staining//qRT-PCR Compared with normal cervical tissues, the expression of SNHG14 was significantly higher in cervical cancer tissues.Subsequently, we investigated the possible underlying mechanism. The results found that the knockdown of SNHG14 enhanced the activation of caspases-3, and increased the protein expression of Bax, JAK2 and STAT3, whereas decreased the expression of Bal-2 and Bid. The prognosis of patients with higher expression of SNHG14 was worse than those with a lower level. The results demonstrated that a higher expression level of SNHG14 indicated later tumor stage and higher incidence of lymph node metastasis. Yes After knocking down SNHG14, the viability and proliferation ability of SW756 and SiHa cells were remarkably decreased, while cell apoptosis was increased. 31114991 SNHG14 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction[miR-206/YWHAZ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this study, we discovered that the relative expression of SNHG14 was significantly upregulated in CC tissues and cells, and associated with the overall survival of CC patients.Molecular mechanism explorations revealed that SNHG14 acted as a sponge of miR-206 and that YWHAZ was a downstream target gene of miR-206 in CC. Spearman's correlation analysis uncovered a significantly negative correlation between SNHG14 (or YWHAZ) and miR-206 expression, while a significantly positive correlation between SNHG14 and YWHAZ expression in CC tissues. We also found that the effect of SNHG14 knockdown on the CC progression could be partly rescued by overexpression of YWHAZ at the same time. Our findings revealed that SNHG14 acted as a sponge of miR-206 to regulate the expression of YWHAZ in CC, hinting the promising therapeutic target role of SNHG4 for CC patients. In this study, we discovered that the relative expression of SNHG14 was significantly upregulated in CC tissues and cells, and associated with the overall survival of CC patients. Yes Moreover, knockdown of SNHG14 significantly inhibited cell proliferation, migration and invasion, and promoted cell apoptosis in CC. 30611620 SNHG14 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Interaction(miR-5590- 3p-ZEB1 /PD-L1) Bioinformatics Analysis//Western Blot SNHG14 was upregulated in NPC tissues. Additionally, the expression of ZEB1 was positively related to that of the SNHG14, while it was inversely correlated with that of miR-5590-3p. Moreover, ZEB1 transcription upregulated PD-L1 and promoted the EMT, while SNHG14 could accelerate the EMT of NPC in vivo by regulating the PD-1 and PD-L1. Yes Knocking down SNHG14 markedly inhibited the EMT of NPC. 34706799 SNHG12 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells regulation[SNHG12/miR-326/E2F1 feedback loop ] qRT-PCR In present study, qRT-PCR manifested the upregulation of SNHG12 expression in OSCC tissues and cells. This research unveiled that SNHG12/miR-326/E2F1 feedback loop facilitated OSCC progression, which shed new light on therapeutic methods in OSCC. Yes Suppression of SNHG12 inhibited cell proliferation, migration, invasion, and EMT process in OSCC. Additionally, SNHG12 depletion also attenuated OSCC tumor growth in vivo. 32506729 SNHG12 LncRNA Homo sapiens Colonic Neoplasms colon cancer samples compared to normal adjacent tissues Interaction(miR-485-3p/FGF3 axis) In Vivo Experiment//IHC//Western Blot//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//cell invasion assay//Colony Formation Assay Here, we found that the expression of lncRNA small nucleolar RNA host gene 12 (SNHG12) was markedly upregulated in colon cancer samples compared to normal adjacent tissues. Notably, patients with low expression of SNHG12 displayed higher survival rate than those with high expression of SNHG12. Yes Further researches revealed that knockdown of SNHG12 suppressed the malignant phenotype of colon cancer cells. Interestingly, SNHG12 could function as a sponge to specifically bind to microRNA-15a (miR-15a). Moreover, we confirmed that pyruvate dehydrogenase kinase 4 (PDK4) is a direct target gene of miR-15a. 34650693 SNHG12 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Interaction[ targeting miR-16-5p] qRT-PCR In this study, SNHG12 was found to be increased in PTC tissues and cell lines using quantitative real-time PCR. Mechanistic investigations revealed that SNHG12 functions as a competing endogenous RNA (ceRNA) to sponge miR-16-5p, which was downregulated in PTC tissues. Yes Knockdown of SNHG12 significantly inhibited PTC cell proliferation, migration and invasion and induced apoptosis in vitro. 31355416 hsa_circ_0088036 CircRNA Homo sapiens Arthritis, Rheumatoid blood regulation[circ0088036/miR-140-3p/SIRT 1 axis] qRT-PCR Our previous study verified that hsa_circ_0088036 (circ0088036) is significantly elevated in peripheral blood mononuclear cells from patients with RA. In conclusion, this study revealed that circ0088036 may play an essential role in promoting synovial pathogenesis via the circ0088036/miR-140-3p/SIRT 1 axis in RA, providing new insight into circRNAs during RA progression. Yes Functionally, upregulated circ0088036 promoted the proliferation and migration of RA-FLSs. 32673817 SNHG12 LncRNA Homo sapiens Carcinoma, Renal Cell renal tissue,cell lines Interaction[HIF1α] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay SNHG12 was aberrantly up-regulated in renal carcinoma both in vivo and in vitro.Mechanistically, SNHG12 modulated HIF1α expression via competing with miR-199a-5p, which consequently contributed to its oncogenic potential. MiR-199a-5p inhibition severely compromised SNHG12 silencing-elicited tumor repressive effects. Yes Deficiency of SNHG12 significantly suppressed cell viability, anchorage-independent growth and induced apoptosis. In addition, SNHG12 silencing inhibited migrative and invasive in vitro and xenograft tumor growth in vivo. 31114448 SNHG12 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tumor tissues regulation[SNHG12/miR-200c-5p/COL11A1 axis ] qRT-PCR//Western Blot "Reverse transcription?quantitative PCR, demonstrated that SNHG12 expression levels were upregulated in RCC tumor tissues, but not in normal kidney tissues. In conclusion, the results of the present study suggested that the SNHG12/miR‑200c‑5p/COL11A1 axis may be crucial for RCC progression, which provided an insight into potential therapeutic strategies for RCC treatment. " Yes SNHG12 knockdown markedly inhibited cell viability and invasion, while increasing apoptosis in both A498 and 786O cell lines. 32901847 SNHG12 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells Regulation(CEP55 ) qRT-PCR//Luciferase Report Assay//Genotyping SNHG12 was highly expressed in RCC tissues and cells, and it was related to the poor prognosis of RCC patients. KMT2B up-regulated SNHG12 expression through modifying H3K4me3 in its promoter region. In addition, SNHG12 promoted CEP55 expression by recruiting the transcription factor E2F1. Knockdown of SNHG12 blocked E2F1 recruitment and down-regulated the expression of CEP55, thereby inhibiting tumor formation and angiogenesis in nude mice. Yes SNHG12 knockdown significantly inhibited RCC cell proliferation, migration, and invasion and HUVEC angiogenesis. 35597996 SNHG12 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines Interaction(miR-516a-5p) qRT-PCR//IHC//RIP SNHG12 and HEG1 were upregulated, miR-516a-5p was downregulated in HCC cell lines. SNHG12 could interact with and inhibit miR-516a-5p. MiR-516a-5p could interact with HEG1 and inhibit HEG1 expression. Yes Knock down SNHG12 inhibited proliferation, migration, invasion, EMT and promoted apoptosis of HCC cells. Such effects were antagonized by inhibiting miR-516a-5p. SNHG12 overexpression lead to opposite results. Similar results were observed in mice. 33774129 SNHG12 LncRNA Homo sapiens Ovarian Neoplasms OC tissues Interaction[absorbing miRNA-129 to Expression[Expression[highly expressed]-expression]regulate SOX4] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay SNHG12 was Expression[Expression[up-expression]-expression]regulated in OC tissues relative to adjacent normal ones. We observed the binding between SNHG12 and miRNA-129, and the latter was lowly expressed in OC. The miRNA-129 overexpression partially reversed the promotive effects of SNHG12 on proliferative and migratory abilities of OC cells. Subsequently, SOX4 was proved to be the target gene of miRNA-129. The SOX4 overexpression was further confirmed to reverse the inhibitory effects of miRNA-129 on proliferative and migratory abilities of OC cells. Patients with metastatic OC or those in stage III-IV had a higher level of SNHG12 compared with non-metastatic or stage I-II patients.The 5-year survival was markedly worse in OC patients with high-level SNHG12 than those in the low-level groExpression[Expression[up-expression]-expression]. Yes Overexpression of SNHG12 accelerated A2780 and HO8910 cells to proliferate and migrate. 30964158 SNHG12 LncRNA Homo sapiens Osteosarcoma cell lines Interaction[targeting miR-195-5p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results show that lncSNHG12 was upregulated in OS cell lines. Also, lncSNHG12 downregulation suppressed the expression of insulin growth factor 1 receptor (IGF1R) expression through sponging miR-195-5p, which was verified with the luciferase reporter assay and rescue experiments. Yes Downregulation lncSNHG12 suppressed the metastasis and proliferation both in vitro and in vivo. 31743769 SNHG14 LncRNA Homo sapiens Pancreatic Neoplasms cancerous tissues Interaction[miR-613] CCK8//qRT-PCR//Western Blot//Transwell Assay SNHG14 expression was up-regulated in cancerous tissues from pancreatic cancer patients. Mechanistic studies revealed that miR-613 was targeted by SNHG14, and Annexin A2 (ANXA2) was targeted and inversely regulated by miR-613 in pancreatic cancer cells. In vivo studies showed that SNHG14 knockdown attenuated tumour growth. MiR-613 was down-regulated and ANXA2 was up-regulated in the pancreatic cancer tissues, and SNHG14 expression levels were inversely correlated with miR-613 expression levels and positively correlated with the ANXA2 mRNA expression levels High expression of SNHG14 was associated with poor tumour differentiation, advanced TNM stage and nodal metastasis. Yes SNHG14 overexpression enhanced cell proliferative, growth and invasive abilities, and suppressed apoptotic rates and caspase-3 activity in pancreatic cancer cells, while SNHG14 knockdown exerted opposite effects. 31513352 SNHG12 LncRNA Homo sapiens Parkinson Disease SH-SY5Y cells Interaction( miR-138-5p) qRT-PCR Transfection of the lncRNA SNHG12-plasmid reduced neuronal apoptosis, inflammation, and oxidative stress in MPP+-stimulated SH-SY5Y cells that were rescued by adding the miR-138-5p mimic. These results showed that lncRNA SNHG12 could affect neuronal apoptosis, inflammation, and oxidative stress in a PD cell model by regulating miR-138-5p expression. TargetScan and dual-luciferase reporter analysis suggested that miR-138-5p targeted nuclear factor I/B (NFIB). Furthermore, the expression level of NFIB was downregulated after MPP+ stimulation in SH-SY5Y cells. Yes Transfection of the lncRNA SNHG12-plasmid reduced neuronal apoptosis, inflammation, and oxidative stress in MPP+-stimulated SH-SY5Y cells that were rescued by adding the miR-138-5p mimic. 34783303 SNHG12 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Regulation[miR-125b/STAT3 axis] qRT-PCR Meanwhile, the expression of SNHG12 was obviously upregulated in cervical cancer cell lines (HeLa, SiHa, Caski, C4-1, and C33A) compared with the immortalized cervical epithelial cells. Meanwhile, miR-125b mimics repressed the expression of signal transducer and activator of transcription 3 (STAT3). The further assay showed that STAT3 was a target of miR-125b in cervical cancer. In addition, sh-STAT3 repressed the migration and invasion of cervical cancer cells. Furthermore, it showed that miR-125b inhibitors reversed STAT3 expression restrained by the reduction of SNHG12 expression. In general, SNHG12 modulated STAT3 by sponging miR-125b in cervical cancer and played an important role in the development of cervical cancer. Yes In addition, SNHG12 inhibition restrained the proliferation, migration, and invasion of cervical cancer cells. 30246459 SNHG12 LncRNA Homo sapiens Glioma glioma tissues and cells Regulation[miR-101-3p/FOXP1 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay SNHG12 expression was enhanced and high-expressed in the glioma clinical tissue samples and cell lines, especially in the advanced clinical grade. Overall, we confirmed a functional regulatory pathway that SNHG12 and miR-101-3p regulated the expression of FOXP1 in glioma cells, forming the SNHG12/miR-101-3p/FOXP1 pathway. SNHG12 expression was enhanced and high-expressed in the glioma clinical tissue samples and cell lines, especially in the advanced clinical grade. Yes In functional study, knockdown of SNHG12 impaired the proliferation, induced the apoptosis in vitro and, meanwhile, inhibited the tumor growth in vivo. 30098431 SNHG12 LncRNA Homo sapiens Glioma glioma tissues and cell lines interaction[HuR] qRT-PCR//RNA Pull-Down//RIP The results revealed that SNHG12 was significantly upregulated in glioma tissues and cell lines. High levels of SNHG12 were associated with the deterioration of patients with glioma. Patients with high levels of SNHG12 exhibited a reduced 5-year overall survival rate (compared to those with lower levels), particularly in cohorts with high-grade carcinoma (III-IV). Yes The silencing of SNHG12 expression by RNA interference led to a reduced viability and mobility, and in an increased apoptosis of human glioma cells. 30015836 SNHG12 LncRNA Homo sapiens Atherosclerosis AS patients and HUVECs Interaction(miR-218-5p/IGF2 axis) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//ELISA//Bioinformatics Analysis We found that SNHG12 and IGF2 expression levels were high and miR-218-5p expression levels were low in AS patients and ox-LDL-treated HUVECs. Overall, SNHG12 promotes the development of AS by the miR-218-5p/IGF2 axis. Yes SNHG12 depletion attenuated ox-LDL-induced injury in HUVECs, whereas miR-218-5p suppression partially abated this effect. Moreover, IGF2 overexpression prevented the alleviative role of miR-218-5p in ox-LDL-treated HUVECs. SNHG12 upregulated IGF2 expression by sponging miR-218-5p. More importantly, SNHG12 increased proinflammatory cytokine production and augmented atherosclerotic lesions in vivo. 34313533 SNHG12 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues Interaction[sponging miR-129-5p and potentiating WWP1] Flow Cytometry//qRT-PCR//MTT//Transwell Assay SNHG12 was significantly overexpressed in LSCC tissues compared with adjacent normal tissues. The expression level of SNHG12 was significantly associated with T classification, lymph node metastasis, and cancer stage of LSCC. High expression of SNHG12 predicted shorter disease-free survival. Yes Our study demonstrated that SNHG12 promoted LSCC cells progression via sponging miR-129-5p and potentiating WWP1 expression. 31348766 SNHG12 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Interaction[sponging microRNA-195] qRT-PCR In the present study, we found that SNHG12 was highly expressed in human PCa tissues and cell lines. Further in-depth mechanistic studies showed that SNHG12 might serve as a competing endogenous RNA for miR-195 in PCa cells, and miR-195 expression level was negatively associated with the expression of SNHG12 in PCa tissues. Finally, we found that the activity of Wnt/β-catenin signaling is enhanced by SNHG12 overexpression and rescued by co-transfection with miR-195 mimics in PCa cells. Collectively, the present study indicated the oncogenic function of SNHG12 in PCa and our findings might provide a new target in the treatment of PCa. Yes In addition, gain-of-function and loss-of-function studies showed that overexpression of SNHG12 promoted, while downregulation suppressed the proliferation, invasion, and migration of PCa cells in vitro. Knockdown of SNHG12 also repressed PCa xenograft tumor growth in vivo. 30945357 SNHG12 LncRNA Homo sapiens Prostatic Neoplasms PCa cells and tissues Interaction[sponging miR-133b] Flow Cytometry//qRT-PCR//CCK8//Colony Formation Assay//Transwell Assay "Results showed that SNHG12 was overexpressed, which indicated a high expression level of SNHG12 in PCa (Figure 1g,h; Table S3). Direct interactions between miR-133b and SNHG12 have been found and SNHG12 acts as an oncogene to promote tumorigenesis of PCa by sponging tumor suppressor gene miR-133b. " "That is, higher SNHG12 expression level was positively correlated with new tumor events after treatment (p < .0001; Figure 3a), positive lymph nodes (p = .0036; Figure 3b), Gleason score 8–10 (p < .0001; Figure 3c) and advanced residual tumor grade R1+R2 (p = .0027; Figure 3d)." Yes " All mentioned above have elucidated that SNHG12 regulates proliferation, migration, invasion, and cell cycle of PCa, thus promoting the development of Pca." 31267540 SNHG12 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Interaction[sponging microRNA-16] CCK8//qRT-PCR//Transwell Assay It was observed that SNHG12 was markedly upregulated in CRC tissues when compared with that in adjacent non-tumour tissues, and its high expression was associated with CRC progression, as well as poor prognosis of patients.In addition, the expression of SNHG12 was higher in CRC cell lines when compared with that in a normal intestinal epithelial cell line.A Bioinformatics analysis predicted that SNHG12 and miR-16 have complementary binding sites, which was confirmed by a luciferase reporter gene assay. The expression levels of miR-16 were markedly decreased in CRC tissues and cell lines compared with those in normal tissues or cells, and were inversely correlated with the expression levels of SNHG12 in CRC tissues. Furthermore, silencing of miR-16 eliminated the suppressive effects of SNHG12 knockdown on CRC cell proliferation and invasion. In conclusion, the present study demonstrated that SNHG12 promotes CRC cell proliferation and invasion, at least in part, by acting as a molecular sponge of miR-16, suggesting that SNHG12 may be a promising therapeutic target for CRC. It was observed that SNHG12 was markedly upregulated in CRC tissues when compared with that in adjacent non-tumour tissues, and its high expression was associated with CRC progression, as well as poor prognosis of patients. Yes Knockdown of SNHG12 significantly inhibited CRC cell proliferation and invasion, while ectopic overexpression of SNHG12 had the opposite effect. 31316616 SNHG12 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCA tissues regulation[SNHG12/miRNA-195-5p/BCL9 network] qRT-PCR SNHG12 was downregulated in human ESCA tissues compared to control tissues. The expression of SNHG12 was strongly associated with T stage, N stage, and TNM stage. Low SNHG12 expression in esophageal tumor tissues was significantly correlated with poor prognosis. Yes Furthermore, knockdown of SNHG12 not only promoted proliferation, colony formation, migration, and invasion and inhibited apoptosis in ESCC cells in vitro, but also increased tumor growth in vivo. 32086782 SNHG12 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC specimens and CD133 cells regulation[BMI1 and CTNNB1] RNA Pull-Down//IHC//Western Blot//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In this study, lncRNA small nucleolar RNA host gene 12 (SNHG12), mainly distributed in ESCC cell cytoplasm, was overexpressed in ESCC specimens and CD133 cells. In summary, SNHG12 induces proliferation, migration, EMT, and stemness of ESCC cells via post-transcriptional regulation of BMI1 and CTNNB1, indicating that targeting SNHG12 might be a novel target for ESCC treatment. +- Yes In CD133 ESCC cells, SNHG12 overexpression promoted cell proliferation, migration, epithelial-mesenchymal transition (EMT), and stemness and SNHG12 silencing led to opposite results. 32239639 SNHG12 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(HuR/PD-L1/USP8 axis) CCK8//qRT-PCR//Colony Formation Assay//RIP LncRNA SNHG12 was found to be prominently expressed in NSCLC tissues and cells, which was associated with a poor prognosis. Mechanically, the binding of lncRNA SNHG12 to HuR improved mRNA stability and expression of PD-L1 and USP8, and USP8-mediated deubiquitination stabilized the protein level of PD-L1. Overexpression of USP8 or PD-L1 weakened the inhibition of silencing lncRNA SNHG12 on the immune escape of NSCLC. LncRNA SNHG12 was found to be prominently expressed in NSCLC tissues and cells, which was associated with a poor prognosis. Yes Silencing lncRNA SNHG12 resulted in the reduction in proliferation and the promotion of apoptosis of NSCLC cells, while simultaneously increasing PBMC proliferation and the ratio of CD8+ T cells. Silencing lncRNA SNHG12 restricted tumor growth and upregulated the ratio of CD8+ T cells by decreasing USP8 and PD-L1. 35658874 SNHG14 LncRNA Homo sapiens Endometrial Neoplasms EC tumor tissues regulation[microRNA-655-3p] CCK8//qRT-PCR//Flow Cytometry//EdU Staining qPCR results indicated that SHHG14 expression in EC tumor tissues was remarkably higher than that in adjacent tissues. Additionally, lncRNA SNHG14 is capable of accelerating malignant progression of EC by regulating microRNA-655-3P expression. Compared with patients with low expression of SNHG14, patients with high expression of SNHG14 had larger tumor size, lower overall survival, and more advanced pathological stage. Yes In vitro, compared with those in the control group, the overexpression of SNHG14 markedly enhanced EC cell proliferation while inhibited cell apoptosis, and the opposite result was observed in SNHG14 silencing group. 33155197 SNHG14 LncRNA Homo sapiens Arthritis, Rheumatoid RA patients Interaction(miR-17-5p/MINK1-JNK pathway) Western Blot//Transfection//qRT-PCR//FISH//Luciferase Report Assay//ELISA//Colony Formation Assay//EdU Staining Here, we found that high expression of SNHG14 in RA was closely related to the disease activity. In mechanism, SNHG14 served as a sponge of microRNA-17-5p (miR-17-5p), and misshapen like kinase 1 (MINK1) was a target of miR-17-5p. Here, we found that high expression of SNHG14 in RA was closely related to the disease activity. Yes Functional assays indicated that SNHG14 knockdown obviously hampered phorbol myristate acetate-activated THP-1 (pTHP-1) cell proliferation and proinflammatory cytokines production. 34529319 SNHG14 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues and cell lines Interaction[SNHG14/miR-5590-3p/ZEB1 ] CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Results depicted that SNHG14 was upregulated in DLBCL and its depletion retarded proliferation, migration and epithelial-to-mesenchymal transition (EMT). In conclusion, we firstly showed that SNHG14/miR-5590-3p/ZEB1 positive feedback loop promoted diffuse large B cell lymphoma progression and immune evasion through regulating PD-1/PD-L1 checkpoint, indicating that targeting SNHG14 was a potential approach to improve the efficacy of immunotherapy in DLBCL. Yes Results depicted that SNHG14 was upregulated in DLBCL and its depletion retarded proliferation, migration and epithelial-to-mesenchymal transition (EMT). 31570691 SNHG14 LncRNA Homo sapiens Pre-Eclampsia PE patients Interaction(miR-330-5p) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//IF//Luciferase Report Assay//Cell Cycle Assay//Invasion Assay//Transwell Assay lncRNA SNHG14 was downregulated in PE patients; it was involved in trophoblast proliferation and regulated cell proliferation during G1/S transition. Luciferase reporter assay indicated that lncRNA SNHG14 served as a molecular sponge for miR-330-5p and negatively regulated miR-330-5p expression in PE. Furthermore, the effects of silenced SNHG14 on trophoblast proliferation, migration, invasion and EMT were reversed by addition of miR-330-5p inhibitor, suggesting that in PE lncRNA SNHG14 functions by competitively binding to miR-330-5p. Yes lncRNA SNHG14 was downregulated in PE patients; it was involved in trophoblast proliferation and regulated cell proliferation during G1/S transition. In addition, lncRNA SNHG14 promoted migration, invasion and epithelial-mesenchymal transition (EMT) in HTR-8/SVneo cells. 33161910 SNHG14 LncRNA Homo sapiens Acute Kidney Injury HK-2 cells Interaction(miR-93/IRAK4 and IL-6R/NF-κB and STAT3 signaling) Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//ChIP Increased expression of SNHG14 was observed in LPS-induced HK-2 cells, and this was due to the activation of the TLR4/NF-κB pathway. Further investigations confirmed that SNHG14 exerted the functions via miR-93 which could regulate the activation of NF-κB and STAT3 signaling by targeting IRAK4 and IL-6R. Yes In vitro studies showed that SNHG14 was involved in the oxidative stress, inflammation, and apoptosis of LPS-induced HK-2 cells. 33505213 SNHG14 LncRNA Homo sapiens Thyroid Neoplasms thyroid tumour cells Interaction(miR-93-5p) In Vivo Experiment//Transwell Assay//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//IHC//IF SNHG14 was upregulated in thyroid tumour cells compared with normal cells. Moreover, SNHG14 directly targeted miR-93-5p and there was a negative correlation between them. Further functional experiments illustrated that miR-93-5p overexpression dramatically reversed the promoting role of SNHG14 in proliferation, migration and invasion of TPC-1 cells. Yes Downregulation of SNHG14 effectively reduced the proliferation, migration and invasion of TPC-1 cells, and induced cell apoptosis. 34380584 SNHG14 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues and cell line Interaction(miR-152-3p) Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//RIP//Transwell Assay The results showed that SNHG14 expression increased and miR-152-3p expression decreased in DLBCL tissues and cell lines, indicating a negative correlation between miR-152-3p and SNHG14 expression.Furthermore, both the immune escape and progression of DLBCL are advanced by SNHG14 expression via its interactions with miR-152-3p. Yes Moreover, SNHG14 was found to promote DLBCL growth, migration, and EMT-like processes in vitro, and directly inhibits miR-152-3p gene expression via sequestration of the miR-152-3p transcripts in DLBCL. Additionally, SNHG14/miR-152-3p inhibits apoptosis and promotes cell proliferation on cytotoxic T lymphocytes (CTLs) in DLBCL via the PD-1/PD-L1 checkpoint. 33682607 Snhg14 LncRNA Mus musculus Parkinson Disease brain tissues Interaction[miR-133b/ α-synuclein pathway] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//ChIP Firstly, we found that the expression level of SNHG14 was elevated in brain tissues of PD mice. Further study showed that miR-133b down-regulated α-syn expression by targeting its 3'-UTR of mRNA and SNHG14 could reverse the negative effect of miR-133b on α-syn expression. Interference of SNHG14 reduced rotenone-induced DA neuron damage through miR-133b in MN9D cells and α-syn was responsible for the protective effect of miR-133b. Similarly, interference of SNHG14 mitigated neuron injury in PD mouse model. All in all, silence of SNHG14 mitigates dopaminergic neuron injury by down-regulating α-syn via targeting miR-133b, which contributes to improving PD. Yes Similarly, interference of SNHG14 mitigated neuron injury in PD mouse model. All in all, silence of SNHG14 mitigates dopaminergic neuron injury by down-regulating α-syn via targeting miR-133b, which contributes to improving PD. 31683259 Snhg14 LncRNA Mus musculus Parkinson Disease brain tissues regulation[miR-214-3p/KLF4 Axis ] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//ELISA Our data indicated that SNHG14 was upregulated and miR-214-3p was downregulated in PD models.Our current study first demonstrated the protective effect of SNHG14 knockdown on MPP-stimulated cytotoxicity in SK-N-SH cells at least partially by targeting the miR-214-3p/KLF4 axis, illuminating a promising target for PD intervention and treatment. + Yes SNHG14 knockdown ameliorated MPP-stimulated damage in SK-N-SH cells, as evidenced by the enhancement in cell viability and the suppression in cell apoptosis and pro-inflammatory cytokine production. 33071725 Snhg14 LncRNA Mus musculus Plaque, Atherosclerotic atherosclerotic plaque tissues interaction[Sponge miR-19a-3p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay In this study, we found a significant decrease in the expression of lncRNA-SNHG14 in atherosclerotic plaque tissues of ApoE-/- mice.The results of qRT-PCR showed that the level of RORα mRNA was significantly increased in the aortas treated with miR-19a-3p and SNHG14 compared with that treated with miR-19a-3p alone. Yes Overexpression of lncRNA-SNHG14 can inhibit VSMC proliferation while promoting apoptosis. 32908577 SNHG12 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[phosphatidylinositol 3-kinase/AKT pathway ] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//FISH//qRT-PCR//Microarray//Transwell Assay Long non-coding RNAs contribute to the development of human cancers. We compared the long non-coding RNA levels in gastric cancer (GC) and para-cancerous tissues in the Gene Expression Omnibus, and found that small nucleolar RNA host gene 12 (SNHG12) was upregulated in GC tissues.Fluorescence in situ hybridization confirmed that SNHG12 is overexpressed in GC tissues.Taken together, cancer pathway microarray and bioinformatics analyses, RNA pulldown assays, Western blotting and immunohistochemistry revealed that SNHG12 induces GC tumorigenesis by activating the phosphatidylinositol 3-kinase/AKT pathway. SNHG12 may thus be a useful marker for predicting poor survival in GC patients. Yes In vitro, silencing SNHG12 suppressed GC cell proliferation, migration and invasion, but induced apoptosis and cell cycle arrest. Overexpressing SNHG12 had the opposite effects. In xenografted mice, knocking down SNHG12 reduced GC tumor growth. 31808752 SNHG12 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines,blood Interaction[targeting miR-16] CCK8//qRT-PCR//Luciferase Report Assay//Migration Assay In the present study, it was observed that SNHG12 was significantly upregulated in GC tissues and cell lines. In conclusion, the present study demonstrates that inhibition of SNHG12 suppresses GC cell proliferation and migration by modulation of miR-16 expression, and thus suggests that the SNHG12/miR-16 interaction may be used as a promising target for GC treatment. High expression of SNHG12 was associated with GC progression and poor prognosis of patients. Yes Knockdown of SNHG12 markedly inhibited the proliferation and migration of the BGC823 and HGC27 GC cell lines. 31258654 SNHG12 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines  Interaction(miR-218-5p/YWHAZ axis) Western Blot//ISH//Co-IP//Migration Assay//qRT-PCR//FISH//Luciferase Report Assay//IHC//ChIP In the present study, we demonstrated that SNHG12 was upregulated in GC tissues and cell lines. the expression level of SNHG12 in GC samples was significantly related to tumor invasion depth, TNM stage and lymph node metastasis and was associated with disease-free survival (DFS) and overall survival (OS) in GC patients. Yes In vivo and in vitro assays indicated that SNHG12 promotes GC metastasis and epithelial-mesenchymal transition (EMT). Bioinformatics and mechanistic analyses revealed that SNHG12 can directly target miR-218-5p to regulate YWHAZ mRNA, forming an SNHG12/miR-218-5p/YWHAZ axis and decreasing the ubiquitination of β-catenin.  33994849 SNHG12 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues Regulation(YWHAZ /AKT/GSK-3β Pathway) In Vivo Experiment//Western Blot//ISH//CCK8//qRT-PCR//RIP//FISH//PCR//IHC " SNHG12 was highly expressed in GC cells and tissues, and predicted poor survival. Bioinformatics analysis predicted that YWHAZ was the common target of SNHG12 and HuR, and that the ""SNHG12-HuR"" complex enhanced the stability of YWHAZ mRNA. Furthermore, YWHAZ, which was highly expressed in GC, predicted poor survival and promoted GC proliferation by phosphorylating AKT. Rescue assays verified that SNHG12 promoted GC proliferation by activating the AKT/GSK-3β pathway." Yes In vitro and in vivo assays showed that SNHG12 knockdown inhibited GC proliferation, while SNHG12 overexpression promoted GC proliferation. 34195070 SNHG12 LncRNA Homo sapiens Breast Neoplasms BC tumors interaction[SALL4,miR-15a-5p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay SNHG12 and SALL4 expressions were upregulated whereas miR-15a-5p was downregulated in BC tumors compared with normal tissues. SNHG12 promotes cell proliferation, migration, and invasion but suppresses apoptosis in BC by upregulating SALL4 expression via sponging miR-15a-5p, representing potential targets for the development of novel diagnosis and treatment methods. Yes More importantly, SNHG12 knockdown attenuated BC tumor growth in vitro and in vivo. 32386479 SNHG12 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[AKT/mTOR pathway] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay In this study, we found that SNHG12 was significantly increased in BC tissues and cells. Knockdown of SNHG12 inhibited cell proliferation, invasion, and migration by regulating miR-451a through suppression of AKT/mTOR pathway in BC. Yes Knockdown of SNHG12 inhibited BC cell proliferation, invasion, and migration in vitro as well as suppressed tumor growth in vivo. 32269676 SNHG12 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues and NSCLC cell lines Interaction(miR-101-3p/CUL4B axis ) RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Our data indicated that SNHG12 targeted and negatively regulated miR-101-3p, and this depletion reversed the inhibitory effect of si-SNHG12 on NSCLC cells. Furthermore, CUL4B was confirmed as a functional target of miR-101-3p, and its knockdown resulted in a strong alleviation of the NSLCL cell phenotype, which was enhanced by the silencing of miR-101-3p. Mechanistically, we found that SNHG12 regulated miR-101-3p to modulate the PI3K/AKT pathway mediated by CUL4B. Yes This study clarified that SNHG12 knockdown significantly reduced proliferation, migration, invasion and EMT of NSCLC cells. 34002487 RP11-20B24.6 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 hsa_circTPT1_003 CircRNA Homo sapiens bladder carcinoma bladder cancer tissues Interaction(has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4 Signaling Axis ) qRT-PCR//Microarray Further excavation analysis showed that seven differentially overexpressed circRNAs including hsa_circ_0000133, hsa_circ_0023610, hsa_circ_0005615, hsa_circ_0030162, hsa_circ_0077007, hsa_circ_0001140, and hsa_circ_0107031 were associated with bladder cancer invasiveness, and the cell cycle signal axis. has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4 was finally clarified as a possible mechanism for bladder cancer progression. Based on results derived from multiple approaches, we identified that has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4 signal axis may be involved in the invasion process of bladder cancer. Yes has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4 was finally clarified as a possible mechanism for bladder cancer progression. 35005988 SNHG3 LncRNA Homo sapiens Uterine Cervical Neoplasms GEO (cervical cancer and adjacent normal tissues) Expression [highly expressed] Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay SNHG3 was over-expressed in cervical cancer tissues and SiHa cells. Yes In SiHa cells, knocking down SNHG3 significantly inhibited the proliferation (P < 0.001), migration (P < 0.01) and invasion abilities (P < 0.001) of the cells, down-regulated the expression levels of N-cadherin, Snail and vimentin (P < 0.001) and up-regulated the expression of E-cadherin (P < 0.001). 34238747 PCGEM1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines regulation[sponging miR-433-3p to upregulate WTAP] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining//Transwell Assay PCGEM1 was highly expressed in NSCLC cells, while miR-433-3p was lowly expressed in NSCLC cells. PCGEM1 accelerates NSCLC progression via sponging miR-433-3p to upregulate WTAP. Yes PCGEM1 silencing or miR-433-3p overexpression inhibited cell proliferation, migration and invasion but accelerated cell apoptosis. 32787827 PCNA-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cell and tissues Interaction(miR-2467-3p/PCNA axis) Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Invasion Assay As a result, PCNA-AS1 was highly expressed in ESCC and was associated with patient prognosis. PCNA-AS1 and PCNA were positively correlated in ESCC. Bioinformatics analysis, RIP and luciferase reporter gene assays revealed that PCNA-AS1 could act as a competitive endogenous RNA to sponge miR-2467-3p, thus upregulating PCNA. As a result, PCNA-AS1 was highly expressed in ESCC and was associated with patient prognosis. Yes PCNA-AS1 overexpression strongly contributed to ESCC cell proliferation, invasion and migration. 36213440 PCNA-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[Upregulating CCND1] CCK8//qRT-PCR//Cell Cycle Assay//Western Blot Our results showed that PCNA-AS1 was upregulated in NSCLC tissues and cell lines, and correlated with TNM stages. Moreover, depletion of CCND1 abrogated the oncogenic roles of PCNA-AS1 in NSCLC. In conclusion, highly expressed PCNA-AS1 promotes NSCLC cell proliferation and oncogenic activity via upregulating CCND1. Our results showed that PCNA-AS1 was upregulated in NSCLC tissues and cell lines, and correlated with TNM stages. Yes Functional experiments showed that overexpression of PCNA-AS1 promoted NSCLC cell proliferation and cell cycle progression. Depletion of PCNA-AS1 inhibited NSCLC cell proliferation and cell cycle progression, and also inhibited NSCLC tumor growth in vivo. 32194807 PCLN16 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] qRT-PCR//Migration Assay The AR-regulated PCLN16 was abundantly overexpressed in localized or metastatic prostate cancer tissues and AR-dependent cell lines. Yes PCLN16 silence suppressed AR signaling and tumor growth. 33387886 hsa_circ_0001742 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues Regulation[ miR-634/RAB1A pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In the present study, results reported that the expression of hsa_circ_0001742 was obviously increased and correlated with TSCC patients with advanced clinical stage, lymph-node metastasis.Thus, our study showed that hsa_circ_0001742 could promote TSCC progression by targeting miR-634/RAB1A pathway. In the present study, results reported that the expression of hsa_circ_0001742 was obviously increased and correlated with TSCC patients with advanced clinical stage, lymph-node metastasis. Yes In vitro function assays revealed that hsa_circ_0001742 inhibition decreased the proliferation, invasion, and epithelial-mesenchymal transition (EMT) processes of TSCC cells. 30944081 PCGEM1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Interaction[regulating SNAI1] qRT-PCR//Western Blot//Transwell Assay LncRNA PCGEM1 was overexpressed in GC cells and tissues, and was induced by hypoxia in GC cells.Our findings indicated that PCGEM1 is a hypoxia-responsive lncRNA, and contributes to the invasion and metastasis of GC. The potential mechanism is attributed to the regulation of EMT by PCGEM1 and its influence on the expression of SNAI1. Yes Additional experiments confirmed that the knockdown of PCGEM1 significantly repressed the invasion and metastasis of GC cells. 30690667 PCGEM1 LncRNA Homo sapiens Stomach Neoplasms GC cells regulation[PCGEM1/miR-129-5p/P4HA2 axis] ISH//qRT-PCR//Luciferase Report Assay//Western Blot GC cells expressed high levels of cytoplasmic PCGEM1.The PCGEM1/miR-129-5p/P4HA2 axis was confirmed to possess a crucial role in GC metastasis and invasion, suggesting its utility as a potential diagnostic and therapeutic biomarker. Yes Loss-of-function experiments displayed that the silencing of PCGEM1 suppressed metastatic and invasive cell qualities. 32622013 PCGEM1 LncRNA Homo sapiens Stomach Neoplasms HGC exosomes Regulation(SNAI1) Western Blot//Wound Healing Assay//qRT-PCR//Invasion Assay//Transwell Assay Long non-coding RNA (lncRNA) prostate cancer gene expression marker 1 (PCGEM1) was specifically expressed in HGC exosomes. On the mechanism, PCGEM1 maintained stability and reduced the degradation of SNAI1, which could induce the epithelial-mesenchymal transition of GC. Yes . HGC-derived PCGEM1-riched exosomes could promote the invasion and migration of NGC. 32519176 PCGEM1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-152-3p) qRT-PCR//Luciferase Report Assay Increased expression of PCGEM1 was observed in NSCLC tissues and cells compared with the corresponding controls (all P < 0.001). The further luciferase reporter assay and expression results showed that miR-152-3p might be a target gene of PCGEM1 and mediate the effects of PCGEM1 on cell proliferation, migration and invasion in NSCLC. PCGEM1 expression was associated with NSCLC patients' lymph node metastasis and TNM stage (all P < 0.05), and the knockdown of PCGEM1 in NSCLC cells led to inhibited cell proliferation, migration and invasion. Yes PCGEM1 expression was associated with NSCLC patients' lymph node metastasis and TNM stage (all P < 0.05), and the knockdown of PCGEM1 in NSCLC cells led to inhibited cell proliferation, migration and invasion. 34455968 PCNAP1 LncRNA Homo sapiens Liver Neoplasms liver tissues Regulation[miR-154/PCNA/HBV cccDNA signaling and the PCNAP1/PCNA signaling] Southern Blot//Western Blot//qRT-PCR//RNA-seq//Luciferase Report Assay//Microarray//ChIP Additionally, our data revealed that the levels of PCNAP1 were significantly elevated in 39 HBV-related HCC patients relative to those in their adjacent non-tumorous liver tissues (Figure ​(Figure1B),1B), supporting that PCNAP1 may be positively related to HBV-related HCC. Yes Functionally, PCNAP1 or PCNA remarkably enhanced HBV replication and accelerated the growth of HCC in vitro and in vivo. 31410212 PCGEM1 LncRNA Homo sapiens Colorectal Neoplasms CRC cells and tumors Interaction(PCGEM1/miR-433-3p/CTCF axis) RNA Pull-Down//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay PCGEM1 possessed a high expression level in CRC cells as well as tumors. CTCF transcriptionally activated PCGEM1 expression. Moreover, PCGEM1 bound miR-433-3p to prevent miR-433-3p from targeting CTCF. We first revealed PCGEM1/miR-433-3p/CTCF positive feedback loop as an oncogenic axis in CRC cells, which potentially provides new clues for the advancement of CRC treatment. Yes Knockdown of PCGEM1 or CTCF impeded proliferation and migration and drove apoptosis of CRC cells. 35872368 PCGEM1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer cells and tissues Interaction(miR-129-5p/SOX4) qRT-PCR//Western Blot We found that PCGEM1 is overexpressed in colorectal cancer cells and tissues, while miR-129-5p is underexpressed. SOX4 is overexpressed in colorectal cancer cells and tissues. Functionally, PCGEM1 silencing can significantly inhibit the proliferation, invasion, and migration of colorectal cancer cells. Mechanically, PCGEM1 acted as a sponge for miR-129-5p and absorbed its expression, and miR-129-5p was found to target SOX4, constructing the axis of PCGEM1/miR-129-5p/SOX4 in colorectal cancer. In conclusion, PCGEM1 mediates the proliferation, invasion, and migration of colorectal cancer cells by targeting miR-129-5p/SOX4 axis. Yes PCGEM1 silencing can significantly inhibit the proliferation, invasion, and migration of colorectal cancer cells. 36193492 PCGEM1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues Expression[highly expressed] qRT-PCR We found that PCGEM1 expression was significantly higher in EC tissues than in normal endometrial tissues via quantitative reverse transcription (qRT)-PCR. Yes The upregulation of PCGEM1 promoted the proliferation, migration, and invasive ability of EC cells while inhibiting apoptosis. The silencing of PCGEM1 had the opposite effects. Nude mouse xenograft assay showed that PCGEM1 overexpression could promote tumor growth in vivo. 30257404 PCGEM1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Regulation[miR-182/FBXW11 axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP Our present study showed that PCGEM1 was significantly upregulated in CC tissues and cell lines. In conclusion, our findings demonstrated that PCGEM1-miR-182-FBXW11 axis play an important role in CC progression, and indicated a promising therapeutic target for CC patients. Overexpression of PCGEM1 was correlated with advanced International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node, distant metastasis and poor prognosis in CC patients. Yes Functionally, PCGEM1 promoted cell proliferation, cell cycle progression, migration and invasion, while suppressed cell apoptosis in CC cells. 31832017 PCGEM1 LncRNA Homo sapiens Glioma glioma tissues and tumor cell lines Interaction(miR-539-5p/CDK6 axis) In Vivo Experiment//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay LncRNA PCGEM1 was upregulated in glioma tissues and tumor cell lines. PCGEM1 played as a competing endogenous RNA (ceRNA) for miR-539-5p to promote CDK6 expression. MiR-539-5p mimics repressed glioma progression while CDK6 overexpression reversed the roles of PCGEM1 knockdown. PCGEM1 upregulation predicted unsatisfactory prognosis. Yes PCGEM1 knockdown inhibited proliferation, colony formation, migration and invasion. PCGEM1 knockdown delayed tumor growth in vivo. 33589577 PCGEM1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(miR-129-5p/CDT1) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay Both PCGEM1 and CDT1 were upregulated in PCa, while miR-129-5p was downregulated and negatively correlated with PCGEM1 and CDT1. PCGEM1 plays a crucial role in the progression of PCa by sponging miR-129-5p as a ceRNA of CDT1. Yes Downregulation of PCGEM1 or CDT1 inhibited the viability, promoted apoptosis and cycle arrest of PCa cells in vitro, and controlled tumor growth in vivo. 35412947 PCGEM1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(miR-506/TRIAP1) RNA Pull-Down//Western Blot//qRT-PCR//RIP//Cell Proliferation Assay//Transwell Assay PCGEM1 expression was increased in PCa tissues and cells. In PCa tissues, High PCGEM1 expression was associated with high Gleason score, distant metastasis and extracapsular extension. miR-506-3p may interact with PCGEM1 or TRIAP1, and the suppressive effect of PCGEM1 knockdown was reversed when TRIAP1 or a miR-506-3p inhibitor was cotransfected. Yes In addition, PCGEM1 knockdown inhibited PCa cell (C4-2B and PC-3) proliferation, invasion and migration. 35109849 PCGEM1 LncRNA Homo sapiens Carcinoma, Renal Cell renal carcinoma cells interaction[miR-433-3p,FGF2 ] qRT-PCR//Luciferase Report Assay//RIP//FISH In this study, PCGEM1 was observed to be lifted in renal carcinoma cells.MiR-433-3p inhibitor could reverse the cell growth and migration caused by PCGEM1 downregulation. Yes Loss-of-function experiments displayed that silencing of PCGEM1 repressed cell proliferation and migration, and activated apoptosis in renal carcinoma. 31958075 PCNAP1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues regulation[miR-340-5p,SOX4] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay lncRNA PCNAP1 was found to be upregulated in human breast cancer tissues, and high lncRNA PCNAP1 levels predicted poor overall survival.Overall, we found that lncRNA PCNAP1 predicted a poor prognosis in breast cancer and promoted cancer metastasis via miR‑340‑5p‑dependent upregulation of SOX4 expression. lncRNA PCNAP1 was found to be upregulated in human breast cancer tissues, and high lncRNA PCNAP1 levels predicted poor overall survival. Yes Function assays showed that knockdown of lncRNA PCNAP1 suppressed the migration and invasion of breast cancer cells in vitro and in vivo. 32945462 hsa_circ_0001742 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and cells Regulation[miR-431-5p/ATF3 axis] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay The expression of circ_0001742 was upregulated in TSCC tissues and cells.Our results demonstrated that circ_0001742 plays a tumor-promoting effect in TSCC cells by serving as a competing endogenous RNA (ceRNA) to regulate miR-431-5p/ATF3 axis, which might provide a potential therapeutic target for TSCC. Yes Knockdown of circ_0001742 inhibited proliferation, migration, invasion and EMT and induced apoptosis in TSCC cells. 31841185 PELATON LncRNA Homo sapiens Crohn Disease CD patient and cell line Interaction(miR-153-5p) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//H&E Staining//Transwell Assay//IF LINC01272 was highly expressed in patients with CD. Knockdown of LINC01272 inhibited TGF-β1-induced epithelial-mesenchymal transition (EMT). Additionally, LINC01272 regulated TGF-β1-induced EMT through the miR-153-5p axis, and knockdown of LINC01272 inhibited EMT in CD mice in vivo. Yes Knockdown of LINC01272 inhibited TGF-β1-induced epithelial-mesenchymal transition (EMT). Additionally, LINC01272 regulated TGF-β1-induced EMT through the miR-153-5p axis, and knockdown of LINC01272 inhibited EMT in CD mice in vivo. 35559411 PGM5-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-484) CCK8//qRT-PCR pgm5-as1 was upregulated in CRC tissues and cell lines; however, its downregulation contributed to the decreasing of cell viability, growth, migration, and invasion of SW480 and HCT116 cells. Moreover, miR-484 was predicted as the target of pgm5-as1, and the downregulation of pgm5-as1 partially restored the elevated cell viability, growth, migration, and invasion that were induced by the inhibition of miR-484 expression in SW480 and HCT116 cells. Yes pgm5-as1 was upregulated in CRC tissues and cell lines; however, its downregulation contributed to the decreasing of cell viability, growth, migration, and invasion of SW480 and HCT116 cells. 32354224 PGM5-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cells Regulation(miR-587/SLIT3 Axis) qRT-PCR//Western Blot PGM5-AS1 and SLIT3 were expressed at low levels in BC, whereas miR-587 exhibited the opposite trend. PGM5-AS1 overexpression significantly inhibited BC cell proliferation and migration, promoted apoptosis in vitro, and alleviated tumor growth in vivo. miR-587 has been shown to be a target of PGM5-AS1, and miR-587 overexpression can reverse the inhibitory effect of PGM5-AS1 upregulation on BC cell growth. Furthermore, miR-587 directly targeted SLIT3 and negatively regulated its expression. PGM5-AS1 inhibited BC cell proliferation and migration while facilitating apoptosis through the miR-587/SLIT3 pathway. PGM5-AS1 represses BC development via the miR-587/SLIT3 axis, indicating that PGM5-AS1 may be a candidate biomarker and target for BC treatment. Yes PGM5-AS1 overexpression significantly inhibited BC cell proliferation and migration, promoted apoptosis in vitro, and alleviated tumor growth in vivo. 36017912 PGM5-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues regulation[miR-140-5p-mediated FBN1] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP Expression of PGM5-AS1, miR-140-5p, and FBN1 was altered by overexpression, shRNA, mimic, or inhibitors in order to investigate how they regulated migration, invasion, and EMT of osteosarcoma cells in vitro. Taken together, PGM5-AS1 depletion causes FBN1 reduction to retard osteosarcoma processes by negatively modulating miR-140-5p. Yes Loss- and gain-of-function approaches were employed in nude mice to detect their roles in tumorigenesis in vivo. 32412676 PGM5-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(miR-4284/DCN) RNA Pull-Down//Western Blot//Bioinformatics Analysis//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//EdU Staining//Transwell Assay Using real-time quantitative polymerase chain reaction or western blotting, PGM5-AS1 and decorin (DCN) were downregulated in CC tissues and cells, whereas miR-4284 was upregulated.Luciferase assay, RNA pull-down assay, and western blotting showed that PGM5-AS1 could sponge miR-4284 to upregulate DCN expression in CC cells. In summary, this study identified that PGM5-AS1 negatively regulates CC cell malignancy by targeting miR-4284/DCN. Yes Additionally, cell functional experiments showed that PGM5-AS1 overexpression led to decreased proliferation, migration, and invasion of CC cells. However, the inhibitory effect of PGM5-AS1 overexpression on CC cells was partly relieved by DCN knockdown because of the targeting interaction between PGM5-AS1, miR-4284, and DCN. 35420507 PFL LncRNA Mus musculus Cardiac Fibrosis hearts of mice Interaction [let-7d/Ptafr] In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//EdU Staining//IF Using a combination of in vitro and in vivo studies, we identified a lncRNA NONMMUT022555, which is designated as a pro-fibrotic lncRNA (PFL), and revealed that PFL is up-regulated in the hearts of mice in response to myocardial infarction (MI) as well as in the fibrotic cardiac fibroblasts (CFs). More importantly, PFL acted as a competitive endogenous RNA (ceRNA) of let-7d, as forced expression of PFL reduced the expression and activity of let-7d. Moreover, let-7d levels were decreased in the MI mice and in fibrotic CFs. Inhibition of let-7d resulted in fibrogenesis in CFs, whereas forced expression of let-7d abated fibrogenesis through targeting platelet-activating factor receptor (Ptafr). Furthermore, overexpression of let-7d by adenoviruses carrying let-7d precursor impeded cardiac fibrosis and improved cardiac function in MI mice. Yes We found that knockdown of PFL by adenoviruses carrying shRNA attenuated cardiac interstitial fibrosis and improved ejection fraction (EF) and fractional shortening (FS) in MI mice. Further study showed that forced expression of PFL promoted proliferation, fibroblast-myofibroblast transition and fibrogenesis in mice CFs by regulating let-7d, whereas silencing PFL mitigated TGF-β1-induced myofibroblast generation and fibrogenesis. 29464008 PELATON LncRNA Homo sapiens Stomach Neoplasms GC cell lines, GC tissues Expression[highly expressed] qRT-PCR//Wound Healing Assay//Transwell Assay We found that LINC01272 was upregulated in GC and was associated with GC staging and lymph node metastasis. We found that LINC01272 was upregulated in GC and was associated with GC staging and lymph node metastasis. Yes The results of wound-healing and Transwell assays revealed that the LINC01272 was closely related to GC cell migration and invasion.LINC01272 knockdown inhibited the migration and invasion ability of GC cells by reducing the expression of EMT-related proteins. Overexpression of LINC01272 had the opposite effect. 32368096 PELATON LncRNA Homo sapiens Lung Neoplasms LUAD tissues Interaction(MiR-7-5p/CRLS1 Axis) Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay LINC01272 was downregulated in LC and low LINC01272 expression had poor prognosis. LINC01272 negatively regulated miR-7-5p and CRLS1 was a target of miR-7-5p. LINC01272 suppressed cell multiplication and induced apoptosis via regulating the miR-7-5p/CRLS1 axis in LC. Yes In A549 and PC-9 cells, LINC01272 inhibited cell viability and multiplication and induced apoptosis. 34099597 PELATON LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-876/ITGB2 axis ) qRT-PCR//Luciferase Report Assay qRT-PCR revealed that LINC01272 was highly expressed and negatively associated with miR-876 in CRC. Moreover, LINC01272 potentially targeted miR-876, and miR-876 potentially targeted ITGB2. We found that LINC01272 was highly expressed in multiple cancers and closely related to core epithelial-mesenchymal transition (EMT) factors and that high levels of LINC01272 are associated with a poor prognosis in CRC patients. Yes Additionally, LINC01272 or ITGB2 silencing reduced, while miR-876 overexpression promoted, the invasiveness and metastatic capacity of CRC cells in vitro. 34093798 PELATON LncRNA Homo sapiens glioblastoma GBM cells Interaction(p53 ) Western Blot//Transfection//Wound Healing Assay//Co-IP//qRT-PCR//RIP//FISH//Transwell Assay PELATON can inhibit the expression of p53 in p53 wild-type GBM cells and regulate the expression of BACH1 and CD44, but it has no effect on p53, BACH1 and CD44 in p53 mutant GBM cells. PELATON and p53 can form a complex through the RNA binding protein EIF4A3. Yes Knockdown of PELATON resulted in smaller mitochondria, increased mitochondrial membrane density, and enhanced sensitivity to ferroptosis inducers to inhibit GBM cell proliferation and invasion. 35574340 PCTST LncRNA Homo sapiens Pancreatic Neoplasms PC tissues Regulation[TACC-3] qRT-PCR Briefly, our data demonstrated that lnc-PCTST expression is down-regulated in PC tissues.In conclusion, lnc-PCTST is a potential tumor suppressor in PC, which inhibits cell proliferation, invasion, tumorigenesis and EMT by modulating TACC-3. Yes Furthermore, lnc-PCTST overexpression in PC cell lines inhibited cell proliferation and invasion in vitro, and tumorigenesis in vivo (using nude mice as animal model), but did not altered cell migration. 29978472 PEG10 LncRNA Homo sapiens Glioma Interaction[JAK1/STAT3 signal pathway] CCK8//qRT-PCR//Western Blot//Transwell Assay Meanwhile, PEG10 silence upregulated the expression of p16 and p53, Bax, cleaved-Caspase-3/9 expression, and downregulated Bcl-2 expression. PEG10 silence upregulated miR-506 expression. Co-transfection with sh-PEG10 and miR-506 inhibitor impaired the tumor suppressive effects. PEG10 knockdown decreased the phosphorylation of Raf/MEK/ERK and JAK1/STAT3-related proteins Raf, MEK, ERK, JAK1 and STAT3. PEG10 knockdown inhibited cell viability, migration and invasion, induced cell apoptosis through miR-506 upregulation, as well as inactivation of Raf/MEK/ERK and JAK1/STAT3 signal pathways. Yes Transfection with sh-PEG10 inhibited cell viability, migration and invasion, and increased cell apoptosis. 31241046 PEG10 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues and cells interaction[sponging miR-101-3p] Flow Cytometry//qRT-PCR//MTT//Transwell Assay PEG10 and KIF2A level were significantly upregulated, while miR-101-3p was downregulated in DLBCL tissues and cells. Besides, miR-101-3p was a target of PEG10 and miR-101-3p could directly target KIF2A. PEG10 promoted KIF2A level by sponging miR-101-3p. Yes PEG10, or KIF2A deletion significantly inhibited the proliferative, migratory, and invasive abilities of DLBCL cells and elevated cell apoptosis in DLBCL cells. 32976381 PDS5B-DT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell line Interaction(miR-206) qRT-PCR Our results showed that Linc1749808 was highly expressed in both HCC tissues and cell lines. Furthermore, Linc1749808 was found to act as a sponge of miR-206. Inhibition of miR-206 counteracted the effect of Linc1749808 knockdown in 97H cells by regulating YAP1 and epithelial-mesenchymal transition (EMT). Yes Linc1749808 expression was significantly correlated with microvascular invasion, metastasis, and prognosis. After the knockdown of Linc1749808, the metastatic potential of 97H and HepG2 cells was attenuated in vitro and in vivo, but the proliferative capacity did not significantly change. 34196215 PD-L1-lnc LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction(c-Myc ) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//Cell Proliferation Assay//Cell Apoptosis Assay//cell invasion assay Similar to PD-L1 mRNA, PD-L1-lnc in various lung adenocarcinoma cells is significantly upregulated by IFNγ. Mechanistically, PD-L1-lnc promotes lung adenocarcinoma progression through directly binding to c-Myc and enhancing c-Myc transcriptional activity. Yes Both in vitro and in vivo studies demonstrate that PD-L1-lnc increases proliferation and invasion but decreases apoptosis of lung adenocarcinoma cells. 33849634 PDIA3P1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and the adjacent normal tissues Regulation[Wnt/β-catenin signaling ] CCK8//qRT-PCR//Invasion Assay//Western Blot In the present study, PDIA3P expression in NSCLC tissues was examined. RT-qPCR analysis showed that PDIA3P expression was significantly higher in NSCLC tissues (Fig. 1A; P<0.05) compared with the control. The present study showed that lncRNA PDIA3P promoted NSCLC progression by regulating Wnt/β-catenin signaling, highlighting a potential therapeutic target for treating patients with NSCLC treatment. In the present study, it was demonstrated that lncRNA PDIAP3 expression was significantly increased in patients with NSCLC, particularly in patients with an advanced Tumor-Node-Metastasis stages and lymph-node metastasis. The Gene Expression Profiling Interactive Analysis database revealed that patients with NSCLC with high lncRNA PDIA3P expression had a poorer disease-free survival rate. Yes Furthermore, functional assays suggested that PDIA3P inhibition significantly suppressed the proliferation and invasion of NSCLC cells in vitro and reduced tumor growth in vivo. 31572559 PDE3B CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR-136-5p/MAP3K2 axis) Western Blot//Flow Cytometry//qRT-PCR//MTT//PCR//Transwell Assay The results showed that circ_PDE3B was highly expressed in ESCC tissues and cells.Circ_PDE3B served as a sponge for miR-136-5p, and miR-136-5p inhibition reversed the roles of circ_PDE3B knockdown in ESCC cells. MAP3K2 was a direct target of miR-136-5p, and miR-136-5p targeted MAP3K2 to inhibit the malignant behaviors of ESCC cells. Furthermore, circ_PDE3B regulated MAP3K2 expression by sponging miR-136-5p. Yes Downregulated circ_PDE3B expression in ESCC cells significantly reduced cell proliferation, migration and invasion. Importantly, circ_PDE3B knockdown inhibited tumor growth in vivo. 36533720 PDCD4-AS1 LncRNA Homo sapiens Breast Neoplasms TNBC tissues and cells regulation[increasing expression of IQGAP2 via miR-10b-5p] Wound Healing Assay//Tunel//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay In this work, PDCD4-AS1 and IQGAP2 were lowly expressed while miR-10b-5p was strongly expressed in TNBC tissues and cells.Our findings identified lncRNA PDCD4-AS1 as a tumor suppressor in TNBC by regulating IQGAP2 expression via miR-10b-5p, giving a novel insight into the regulatory mechanism of PDCD4-AS1 in the pathogenesis of TNBC. Yes PDCD4-AS1 or IQGAP2 overexpression effectively attenuated TNBC cell proliferation, migration and invasion, and increased the apoptosis rate, while this effect was abandoned in response to miR-10b-5p mimics transfection. 33248413 PDCD4-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms 42 fresh tissue samples of TNBC and adjacent normal tissues Interaction(IQGAP2 via miR-10b-5p) Western Blot//Transfection//Wound Healing Assay//Tunel//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this work, PDCD4-AS1 and IQGAP2 were lowly expressed while miR-10b-5p was strongly expressed in TNBC tissues and cells. miR-10b-5p bound to IQGAP2 and acted as a downstream target of PDCD4-AS1. Yes PDCD4-AS1 or IQGAP2 overexpression effectively attenuated TNBC cell proliferation, migration and invasion, and increased the apoptosis rate, while this effect was abandoned in response to miR-10b-5p mimics transfection. 33248413 PCGEM1 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines regulation[miR-642a-5p/LGMN axis] qRT-PCR//Luciferase Report Assay In the present study, PCGEM1 was over-expressed in cervical carcinoma cells as evidenced by real-time quantitative polymerase chain reaction (RT-qPCR) assay. Taken together, our data indicated that knockdown of PCGEM1 inhibited proliferation, migration and invasion in cervical carcinoma by modulating the miR-642a-5p/ LGMN axis. Yes Knockdown of PCGEM1 significantly repressed proliferation, migration, and invasion, while induced G1 arrest in cervical carcinoma cells. 33121976 PCED1B-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue samples and cell line Interaction(miR-10a/BCL6 Axis) CCK8//qRT-PCR PCED1B-AS1 is upregulated in HCC, and its upregulation correlates with poor survival. Across HCC tissues, PCED1B-AS1 expression inversely correlates with miR-10a but positively correlates with BCL6. In HCC cells, overexpression of PCED1B-AS1 decreases miR-10a expression and increases BCL6 expression. Moreover, PCED1B-AS1 overexpression reduces the inhibitory effects of miR-10a overexpression on BCL6 expression and cell proliferation. PCED1B-AS1 is upregulated in HCC and regulates the miR-10a/BCL6 axis to promote cell proliferation. PCED1B-AS1 is upregulated in HCC, and its upregulation correlates with poor survival. Yes Moreover, PCED1B-AS1 overexpression reduces the inhibitory effects of miR-10a overexpression on BCL6 expression and cell proliferation. PCED1B-AS1 is upregulated in HCC and regulates the miR-10a/BCL6 axis to promote cell proliferation. 35997114 PGM5-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[lower expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Then, we showed that the expression levels of PGM5-AS1, B3GALT5-AS1 and PGM5 were significantly downregulated in CRC tissues compared with corresponding normal tissues. Yes Functionally, overexpression of PGM5-AS1 could induce cell apoptosis and cell cycle arrest in CRC. Animal study indicated that PGM5-AS1 overexpression inhibited CRC growth in vivo. 31619123 PCAT6 LncRNA Homo sapiens Ovarian Neoplasms OC tissues Interaction(miR-143-3p) qRT-PCR//Western Blot PCAT6 expression was significantly increased in OC tissues and positively correlated with advanced stages and with poor overall survival, progression-free survival and post-progression survival.Notably, PCAT6 bound to miR-143-3p and affected the expression of transforming growth factor (TGF)-β-activated kinase 1 (TAK1). Subsequent rescue assays confirmed that upregulation of miR-143-3p decreased the PCAT6 overexpression-induced promotion of proliferation, migration and invasion. Moreover, downregulation of miR-143-3p reversed the PCAT6 knockdown-induced inhibition of proliferation, migration, and invasion. PCAT6 expression was significantly increased in OC tissues and positively correlated with advanced stages and with poor overall survival, progression-free survival and post-progression survival. Yes Knockdown of PCAT6 in A2780 and SKOV3 cells inhibited OC cell proliferation, migration and invasion. In contrast, Overexpression of PCAT6 exerted the opposite effects on OC cells. 33634115 PCAT6 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues regulation[RB/E2F and Wnt/β-catenin pathways] qRT-PCR//Luciferase Report Assay PCAT6 was highly expressed in GC cells and tissues.Finally, PCAT6 was a target of miR-15a. Silencing of lncRNA PCAT6 restrained proliferation and EMT of GC cells by targeting miR-15a via RB/E2F and Wnt/β-catenin pathways. Yes Silencing of PCAT6 restrained the relate-proteins of cell proliferation and EMT. 32039820 PCAT6 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines. Interaction(miR-326/LRRC8E axis) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Our findings revealed that PCAT6 was overexpressed in breast cancer tissues and cell lines.We also found that the transcription factor SP1 could bind to the PCAT6 promoter and promoted its expression. Subsequently, it was verified that PCAT6 was a molecular sponge for microRNA-326 (miR-326), and the leucine-rich repeat containing the eight family member E (LRRC8E) was a direct target of miR-326. Rescue assays revealed that LRRC8E overexpression attenuated the suppressive effect of PCAT6 knockdown on cellular progression of breast cancer. Furthermore, elevation of PCAT6 reflected an adverse prognosis of patients. Yes Functional experiments indicated that PCAT6 knockdown hampered cell proliferation, facilitated apoptosis and cell cycle arrest in vitro, and inhibited tumor growth in vivo. 34620745 PCAT6 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Expression[Expression[highly expressed]-expression] CCK8//qRT-PCR//ELISA We found that KDM5BAS1 was significantly overexpressed in tumor specimens and selected cancerous cell lines. Meanwhile, higher KDM5BAS1 expression predicted poor overall survival. Yes Increased KDM5BAS1 expression can promote proliferation or migration and inhibit apoptosis in H1838 and H1299 cells. Furthermore, knocking Expression[down-expression] of KDM5BAS1 levels can also reduce tumor growth in in vivo implantation experiments. 31562647 PCAT6 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Interaction(miR-326/KLF1 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//ELISA//Transwell Assay In addition, dual-luciferase reporter assay illustrated that miR-326 was the target of PCAT6 and KLF1 was the target of miR-326 in NSCLC cells. Moreover, NSCLC cells-derived exosomes could promote macrophages M2 polarization by transporting PCAT6. Meanwhile, macrophages M2 polarization was able to promote the metastasis and epithelial-mesenchymal transition (EMT) process of NSCLC cells via regulating PCAT6/miR-326/KLF1 axis. Yes We found knockdown of PCAT6 significantly inhibited the viability, migration, and invasion of NSCLC cells. 35609331 PCAT6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tumor tissues and cell lines Expression(highly expressed) CCK8//qRT-PCR//Western Blot In the current study, we discovered that lncRNA PCAT6, which was aberrantly upregulated in ESCC tumor tissues, significantly promoted cell proliferation and migration in ESCC cell lines Eca-109 and Kyse-30 cells. Flow cytometry assays showed that PCAT6 knockdown promoted the apoptosis of ESCC cells. Furthermore, real-time PCR and western blot assays validated that knockdown of PCAT6 could increase the levels of GDF15 and DUSP4 in Eca-109 and Kyse-30 cells. Yes In the current study, we discovered that lncRNA PCAT6, which was aberrantly upregulated in ESCC tumor tissues, significantly promoted cell proliferation and migration in ESCC cell lines Eca-109 and Kyse-30 cells. Flow cytometry assays showed that PCAT6 knockdown promoted the apoptosis of ESCC cells. Mechanistically, RNA-seq and Gene Ontology analyses indicated that PCAT6 knockdown influenced the expression of genes that participated in cell proliferation and migration. 35069911 PCAT6 LncRNA Homo sapiens Carcinoma, Hepatocellular Expression[highly expressed] qRT-PCR//MTT//Migration Assay The result revealed that the expression of PCAT6 was significantly higher in LIHC samples than adjacent samples Yes Knockdown of PCAT6 could inhibit cell proliferation and migration in hepatocellular carcinoma (LIHC) cells. 30968586 PCAT6 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR And we found that PCAT6 was significantly upregulated in HCC tissues and correlated with poor overall survival and disease-free survival in HCC patients. And we found that PCAT6 was significantly upregulated in HCC tissues and correlated with poor overall survival and disease-free survival in HCC patients. Yes Furthermore, elevated PCAT6 promoted cell proliferation, inhibited cell cycle arrest and cell apoptosis while deficiency of PCAT6 impaired cell proliferation, caused cell cycle arrest and induced cell apoptosis of HCC. 32064636 PCAT6 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Interaction[PTEN] CCK8//qRT-PCR//Wound Healing Assay QRT-PCR results showed that the expression level of PCAT6 in ovarian cancer was higher than that in the adjacent normal tissues.QRT-PCR results demonstrated that the PTEN expression was increased after the knockdown of PCAT6. In addition, the recovery experiment also revealed that PCAT6 and PTEN have a mutual regulation, which can jointly regulate the development of ovarian cancer. The incidence of distant metastasis and lymph node metastasis in patients with high expression of PCAT6 was higher than those with low PCAT6 expression. Yes The overexpression of GAS5 suppressed the protein level of COX-2, and inhibited cell proliferation of LPS-induced RWPE-1 cells and HPECs, which was rescued by the co-transfection with pcDNA-GAS5 and pcDNA-COX-2. 31646553 PCAT6 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissue Expression[highly expressed] qRT-PCR We identified that the expression level of PCAT6 in BC tissue was higher than that in adjacent normal tissues. In addition, the expression level of PCAT6 was correlated with tumor size (p = 0.005), differentiation (p = 0.018), TNM stage (p = 0.04), lymph nodes metastasis (p = 0.019), and distant metastasis (p = 0.028). Kaplan-Meier analysis showed that BC patients with high PCAT6 expression had shorter overall survival (OS) and progression-free survival (PFS). Yes The loss-of-function results revealed that the proliferation and viability of BC cells in PCAT6 knockdown groups decreased significantly, compared with the negative control groups. 33142195 PCAT7 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell line Interaction(miR-486-5p/CDK4 axis) CCK8//qRT-PCR GEPIA combined ENCORI database illustrated that LncRNA PCAT7 was upregulated dramatically in NSCLC. The mRNA level of PCAT7 cells was higher than that in normal cells. Data from ENCORI website showed that miR-486-5p was the target of PCAT7 and was negatively controlled by it. The data also showed that CDK4 could be bound and negatively regulated by miR-486-5p. MiR-486-5p inhibitor or CDK4 could partly restore the inhibitory effect of PCAT7 in NSCLC cells. In addition, silencing PCAT7 could arrest cell cycle to S in addition to G2 stage while transfecting miR-486-5p inhibitor or CDK4 could partially eliminate the retarding effects. Yes Silencing PCAT7 inhibited the progression of NSCLC cells significantly. 35702078 PCAT6 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines interaction[targeting miR-513a-5p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay PCAT6 expression was upregulated, while miR-513a was downregulated in BC tissues and cell lines.Our study illustrated that PCAT6 knockdown inhibited cell progression of BC by regulating miR-513a, suggesting that PCAT6 might act as a prognostic biomarker and therapeutic target for BC patients. BC patients with high expression of PCAT6 exhibited a shorter overall survival time compared with those patients with low expression of PCAT6. Yes Moreover, PCAT6 knockdown notably suppressed cell progression. 33090394 PCAT6 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction(microRNA-143-3p/PDIA6 axis) qRT-PCR//Wound Healing Assay The results demonstrated that the expression levels of PCAT6 were upregulated in bladder cancer tissues relative to those in adjacent normal bladder tissues. Collectively, the results of the present study demonstrated that PCAT6 may serve an oncogenic role in bladder cancer via the miR-143-3p/PDIA6 axis. Yes Knockdown of PCAT6 served a role in suppressing the proliferation, migration and invasion of T24T and EJ bladder cancer cells. PCAT6 knockdown contributed to a reduction of PDIA6 expression at the mRNA and protein levels compared with that in negative control-transfected cells, whilst the miR-143-3p inhibitor partially mitigated this reduction effect. 34335889 PCAT6 LncRNA Homo sapiens Osteosarcoma OS tissues Regulation[PCAT6-miR-185-5p-TGFBR1/2-TGF-β signaling axis ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that PCAT6 was elevated in OS tissues relative to that in their adjacent normal tissues. This study uncovers a novel underlying molecular mechanism of PCAT6-miR-185-5p-TGFBR1/2-TGF-β signaling axis in promoting tumor progression in OS, which indicates that PCAT6 may serve as a promising prognostic factor and therapeutic target again OS. The upregulation of PCAT6 was positively associated with metastasis status and advanced stages and predicted poor overall and progression-free survivals in patients with OS. Yes Functionally, silencing PCAT6 inhibited the proliferation, migration and invasion abilities of OS cells. 31676070 PCAT6 LncRNA Homo sapiens Osteosarcoma regulation[MDM2 , P53 ,P21] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay To conclude, lncRNA PCAT6 promoted the proliferation, migration and invasion of osteosarcoma cells by promoting the expression of MDM2 and suppressing the expression of P53 and P21. Yes The present study found that the proliferation, migration and invasion of osteosarcoma cells increased following overexpression of lncRNA PCAT6. 33125146 PCAT6 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues regulation[miR-185-5p/CBX2 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our study confirmed that PCAT6 expression was upregulated in PDAC and the expression of PCAT6 was related to TNM stage, lymph node invasion and overall survival of PDAC patients.The results above suggested that PCAT6/miR-185-5p/CBX2 exerted crucial functions in tumorigenesis and progression of PDAC. Our study confirmed that PCAT6 expression was upregulated in PDAC and the expression of PCAT6 was related to TNM stage, lymph node invasion and overall survival of PDAC patients. Yes Moreover, knockdown of PCAT6 inhibited cell proliferation, migration and invasion of PDAC in vitro. 32825947 PCAT6 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Regulation[Wnt/β-catenin signaling pathway] Western Blot//CCK8//qRT-PCR//EdU Staining//Transwell Assay We found that PCAT6 expression was significantly up-regulated in human CC tissues and cell lines compared with their normal counterparts, and its high levels were associated with advanced FIGO stage, depth of cervical invasion and positively lymph node metastasis.Mechanistic investigation showed PCAT6 activates Wnt/β-catenin signaling in CC cell lines by promoting the expression of β-catenin, cyclin D1 and c-myc. We found that PCAT6 expression was significantly up-regulated in human CC tissues and cell lines compared with their normal counterparts, and its high levels were associated with advanced FIGO stage, depth of cervical invasion and positively lymph node metastasis. Survival assays indicated that high PCAT6 expression had a negative influence on overall survival and disease-free survival. Yes Functionally, knockdown of PCAT6 significantly suppressed CC cells proliferation, migration and invasion, and promoted apoptosis. 30915737 PCAT6 LncRNA Homo sapiens Prostatic Neoplasms PCa tissue Regulation(IGF2BP2/IGF1R RNA-protein three-dimensional complex) In Vivo Experiment//ISH//qRT-PCR//Cell Proliferation Assay//IHC PCAT6 was upregulated in PCa tissues with bone metastasis and increased PCAT6 expression predicted poor prognosis in PCa patients. Mechanistically, METTL3-mediated m6 A modification contributed to PCAT6 upregulation in an IGF2BP2-dependent manner. Furthermore, PCAT6 upregulated IGF1R expression by enhancing IGF1R mRNA stability through the PCAT6/IGF2BP2/IGF1R RNA-protein three-dimensional complex. Importantly, PCAT6 inhibition by ASO in vivo showed therapeutic potential against bone metastasis in PCa. Finally, the clinical correlation of METTL3, IGF2BP2, IGF1R, and PCAT6 was further demonstrated in PCa tissues and cells. Yes Functional experiments found that PCAT6 knockdown significantly inhibited PCa cell invasion, migration, and proliferation in vitro, as well as bone metastasis and tumor growth in vivo. Importantly, PCAT6 inhibition by ASO in vivo showed therapeutic potential against bone metastasis in PCa. Finally, the clinical correlation of METTL3, IGF2BP2, IGF1R, and PCAT6 was further demonstrated in PCa tissues and cells. 34185427 PCAT6 LncRNA Homo sapiens Liver Neoplasms liver cancer tissues Interaction(miR-326/hnRNPA2B1 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay The present study showed that the expression of PCAT6 and heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) was upregulated in liver cancer tissues compared with non-cancerous tissues and were associated with poor overall survival time, whereas microRNA (miR)-326 expression was downregulated. A dual-luciferase reporter gene assay demonstrated that PCAT6 could bind to miR-326 and that hnRNPA2B1 was a direct target gene of miR-326. The present study showed that the expression of PCAT6 and heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) was upregulated in liver cancer tissues compared with non-cancerous tissues and were associated with poor overall survival time, whereas microRNA (miR)-326 expression was downregulated. Yes Moreover, knockdown of PCAT6 significantly inhibited the proliferation and invasion of liver cancer cells in vitro and in vivo. 33907581 PCAT6 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues interaction[microRNA-30] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay PCAT6 was overexpressed in gastric cancer tissues than those of paracancerous tissues.PCAT6 is overexpressed in gastric cancer, which promotes the development of gastric cancer by endogenously competition with microRNA-30 via targeting MKRN3. PCAT6 expression was negatively correlated to prognosis, tumor size, TNM (tumor node metastasis) stage and metastasis of gastric cancer. Yes For in vitro experiments, overexpression of PCAT6 increased proliferation, migration, and invasion, whereas decreased apoptosis of gastric cancer cells. 30178843 circMACF1 CircRNA Homo sapiens acute myocardial infarction MI patients Interaction(miR-500b-5p-EMP1 Axis) qRT-PCR//Tunel//Western Blot In the MI group, the expression levels of circMACF1 and EMP1 were decreased with the increasing expression level of miR-500b-5p.CircMACF1 upregulated the expression of EMP1 as a sponge of miR-500b-5p, and circMACF1 was a direct target of miR-500b-5p. CircMACF1 impaired the progression of AMI by modulating the miR-500b-5p/EMP1 axis. Yes CircMACF1 upregulated the expression of EMP1 as a sponge of miR-500b-5p, and circMACF1 was a direct target of miR-500b-5p. CircMACF1 impaired the progression of AMI by modulating the miR-500b-5p/EMP1 axis. 32162171 PCED1B-AS1 LncRNA Homo sapiens colorectal adenocarcinoma colorectal adenocarcinoma tissues and corresponding cell lines Regulation(miR-633/HOXA9 axis) Transfection We found that PCED1B-AS1 was upregulated and miR-633 was downregulated in colorectal adenocarcinoma tissues and corresponding cell lines. Knockdown of PCED1B-AS1 inhibited cell proliferation and promoted apoptosis, while miR-633 inhibitor elevated proliferation and reduced apoptosis of cancer cell lines. In addition, overexpression of HOXA9 obviously attenuated the protective role of knockdown of PCED1B-AS1 or miR-633 mimics in colorectal adenocarcinoma progression. PCED1B-AS1 could negatively regulate the expression of HOXA9 by sponging miR-633. The in vivo experiments confirmed the role of PCED1B-AS1 and miR-633 in colorectal adenocarcinoma, as well as the regulatory relationship of this axis. Our results demonstrated that knockdown of PCED1B-AS1 inhibited the progression of colorectal adenocarcinoma by regulating the miR-633/HOXA9 axis. Yes Our results demonstrated that knockdown of PCED1B-AS1 inhibited the progression of colorectal adenocarcinoma by regulating the miR-633/HOXA9 axis. 35176937 PCBP2-OT1 LncRNA Homo sapiens Esophageal Neoplasms esophageal malignancy tissues Regulation CCK8//qRT-PCR//Western Blot Fluorescence reckonable PCR exhibit that TUC338 was exceptionally communicated in esophageal cancer tissues, and was significantly related with metastasis and TNM stage in tolerant. Yes Functional experiments showed that in esophageal disease cell lines, knocking down the declaration of TUC338 significantly inhibited cell multiplication, clone development, and intrusion and movement. Further experiments on molecular mechanisms showed that knocking down TUC338 inhibited statement of N-cadherin and vimentin in cells. 34164197 PCED1B-AS1 LncRNA Homo sapiens Osteosarcoma tissues from OS patients and cell lines Interaction(miR-10a) qRT-PCR//Transwell Assay PCED1B-AS1 level was increased in OS and positively correlated with miR-10a level. In OS cells, PCED1B-AS1 siRNA silencing downregulated miR-10a. Methylation-specific PCR analysis showed that PCED1B-AS1 siRNA silencing decreased the methylation of miR-10a gene promoter. Moreover, PCED1B-AS1 siRNA silencing suppressed OS cell proliferation, invasion, and migration. In addition, miR-10a overexpression attenuated the effects of PCED1B-AS1 siRNA silencing. Yes Moreover, PCED1B-AS1 siRNA silencing suppressed OS cell proliferation, invasion, and migration. 36274134 PCED1B-AS1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tumor tissues Interaction(miR‑411‑3p/HIF‑1α axis) CCK8//qRT-PCR//EdU Staining We demonstrated that PCED1B‑AS1 was significantly upregulated in PDAC tumor tissues, and its expression was associated with advanced Tumor‑Node‑Metastasis stage and lymph node metastasis. Mechanistically, PCED1B‑AS1 was shown to target miR‑411‑3p, resulting in the upregulation of HIF‑1α. We demonstrated that PCED1B‑AS1 was significantly upregulated in PDAC tumor tissues, and its expression was associated with advanced Tumor‑Node‑Metastasis stage and lymph node metastasis. Yes PCED1B‑AS1 knockdown inhibited PDAC cell proliferation, invasion as well as epithelial‑mesenchymal transition (EMT) in vitro. 34036383 PCED1B-AS1 LncRNA Homo sapiens Glioma Regulation[miR-194-5p/PCED1B axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay The modulation mechanism of the PCED1B-AS1/miR-194-5p/PCED1B axis in glioma was investigated and affirmed, which supports researchers with a new insight into the therapy of patients with glioma. Yes Loss-of-function experiments depicted that the proliferation ability was restrained and apoptosis ability was induced in glioma cells by PCED1B-AS1 silencing and this phenomenon was also observed when PCED1B was knocked down. 31680313 PCED1B-AS1 LncRNA Homo sapiens Glioblastoma GBM tissues and cell lines regulation[Upregulating HIF-1α] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//IHC PCED1B-AS1 was notably upregulated in GBM tissues and cell lines and closely associated with larger tumor size and higher grade. Taken together, our findings demonstrate that PCED1B-AS1 is a novel oncogenic lncRNA in GBM and functions in a HIF-1α-dependent manner, which provides a promising prognostic biomarker and druggable target for GBM. Patients with high PCED1B-AS1 had shorter survival time than those with low PCED1B-AS1. Yes Functional experiments showed that depletion of PCED1B-AS1 significantly inhibited, while overexpression of PCED1B-AS1 promoted cell proliferation, glucose uptake, and lactate release. 32326742 PCED1B LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(microRNA-215-3p / C-X-C motif chemokine receptor 1 axis) Western Blot//EdU Staining//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay We demonstrated that, PCED1B-AS1 expression level was raised in GC tissues and cell lines, and increased expression of PCED1B-AS1 was in association with tumor size, TNM stage and lymph node metastasis in GC patients. Mechanistically, PCED1B-AS1 specifically inhibited miR-215-3p expressions, thus up-regulating CXCR1 expressions. We demonstrated that, PCED1B-AS1 expression level was raised in GC tissues and cell lines, and increased expression of PCED1B-AS1 was in association with tumor size, TNM stage and lymph node metastasis in GC patients. Yes Additionally, PCED1B-AS1 overexpression promoted GC cells proliferation, migration, invasion and EMT, and miR-215-3p overexpression counteracted the biological effects of PCED1B-AS1. 34516330 PCDHB17P LncRNA Homo sapiens Breast Neoplasms human breast cancer tissues and cell lines Interaction(miR-145-3p/MELK/NF-κB Feedback Loop) Western Blot//Wound Healing Assay//FISH//RIP//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay Here, we demonstrated that lncRNA PCDHB17P was up-expressed in human breast cancer tissues and cell lines. MiR-145-3p was significantly decreased in breast cancer samples, which was negatively correlated to the expression of PCDHB17P. Mechanistic investigation indicated that PCDHB17P acted as a cancer-promoting competing endogenous RNA (ceRNA) by binding miR-145-3p and upregulating MELK.Interestingly, MELK could in turn increase the promoter activity and expression of PCDHB17P via NF-κB, thus forming a positive feedback loop that drives the metastasis and angiogenesis of breast cancer. Yes Knockdown of PCDHB17P remarkably suppressed migration and invasion, as well as tube formation ability of breast cancer cells. 34350110 PCDH10 CircRNA Homo sapiens Pancreatic Neoplasms PC cells Interaction(miR-338-3p/hTERT axis) colony Formation Assay//Wound Healing Assay//Transfection//RIP//IF//PCR//IP//Colony Formation Assay//Transwell Assay Our research found that the PCDH10 gene could be transcribed into linear mRNA or circular RNA, and FUS could bind to the introns flanking the circularized exons, inducing the PCDH10 linear mRNA to shift to circPCDH10 in PC cells. Mechanistically, circPCDH10 acted as a sponge of miR-338-3p, which could negatively regulate hTERT expression in PC cells. Yes Knockdown of circPCDH10 significantly inhibited PC progression. 34017382 PCBP2-OT1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction[upregulating miR-10b] qRT-PCR We found that TUC338 was upregulated in early-stage bladder cancer patients and showed early diagnostic values. After surgical resection, plasma levels of TUC338 were significantly downregulated. Bladder cancer cells with TUC338 overexpression showed upregulated miR-10b, while miR-10b overexpression failed to significantly affect TUC338. Yes TUC338 and miR-10b overexpression significantly promoted bladder cancer cell invasion and migration. 31162712 PCBP2-OT1 LncRNA Homo sapiens prostate carcinoma PC tissues Interaction[downregulatingmiR-466] qRT-PCR//Transwell Assay It was observed that TUC338 was Expression[up-expression]regulated in tumor tissues comparing to adjacent healthy tissues of prostate carcinoma patients. TUC338 and miR-466 were inversely correlated in tumor tissues. miR-466 overexpression failed to affect TUC338 expression, while TUC338 overexpression led to downregulated miR-466 expression. Plasma levels of TUC338 were also higher in prostate carcinoma patients than in healthy controls. A 5-year follow-Expression[up-expression] study showed that high plasma level of TUC338 was correlated with poor survival. Yes TUC338 overexpression failed to significantly affect cancer cell proliferation, but promoted cancer cell migration and invasion. 31085276 PCBP1-AS1 LncRNA Homo sapiens vulva squamous cell carcinoma VSCC tissues and cells Interaction[TRAF5 and NF-κB] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay PCBP1-AS1 and TRAF5 mRNA expression were downregulated in VSCC tissues and were correlated with patient clinicopathological characteristics. As a tumor suppressor gene, PCBP1-AS1 regulates the proliferation and apoptosis of VSCC via TRAF5-mediated expression of the NF-κB. Yes Increase of PCBP1-AS1 significantly inhibited proliferation and enhanced apoptosis via TRAF5-mediated regulation of the NF-κB signaling pathway. 35116901 PCBP2-OT1 LncRNA Homo sapiens Nasopharyngeal Neoplasms NPC cells Interaction(miR-1226-3p/FGF2 axis) In Vivo Experiment//RNA Pull-Down//IP//Western Blot//qPCR//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay Higher level of TUC338 was also observed in NPC cells. Mechanistically, TUC338 acted as molecular sponge of miR-1226-3p and attenuated the negative regulation of miR-1226-3p on the expression of fibroblast growth factor 2 (FGF2). Interestingly, NPC patients harboring overexpressed TUC338 have worse prognosis. Yes Functional study indicated that down-regulated TUC338 remarkably suppressed the NPC cell proliferation and cell migration. Notably, depletion of TUC338 significantly inhibited the in vivo tumor growth. 36224455 PCBP2-OT1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues Interaction( miR-28-5p/EGFR/PI3K/AKT Signaling Pathway) In Vivo Experiment//RNA Pull-Down//Transfection//Immunoblotting//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay In this study, we found that TUC338 was remarkably upregulated in DLBCL tissues as compared to matched normal tissues. Further, we found that TUC338 was able to directly bind to miR-28-5p and increased EGFR level, resulting in activating carcinogenic PI3K/AKT signaling, thereby facilitating DLBCL uncontrolled growth. High TUC338 was closely related to advanced Ann Arbor stage, resistance to CHOP-like treatment, and high IPI (International Prognostic Index). Yes Stable knockdown of TUC338 evidently inhibited cell proliferation and chemotherapy resistance to Adriamycin and induced apoptosis. 33986803 hsa_circ_0119872 CircRNA Homo sapiens Melanoma MM tissues and cell lines Interaction(miR-582-3p/E2F3 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay Circ_0119872 was remarkably upregulated in MM tissues and cell lines. In addition, miR-582-3p was identified as a downstream target of circ_0119872. The target genes of miR-193a-3p are involved in melanogenesis and cancer-related signaling pathways. Mechanistically, circ_0119872 facilitated MM progression by adsorbing miR-582-3p and upregulating E2F3 expression. Yes Circ_0119872 knockdown suppressed the cell proliferation and metastasis 34644734 hsa_circ_0079593 CircRNA Homo sapiens Melanoma melanoma tissues and cells Interaction(miR-573/ABHD2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay Our data showed that circ_0079593 level was up-regulated in melanoma tissues and cells.Mechanistically, circ_0079593 directly targeted miR-573, and circ_0079593 controlled ABHD2 expression by miR-573. MiR-573 mediated the regulation of circ_0079593 on melanoma cell progression in vitro. Yes The knockdown of circ_0079593 suppressed cell proliferation, cell cycle progression, migration, invasion, and enhanced apoptosis in vitro and inhibited tumor growth in vivo. 33648800 hsa_circ_0084043 CircRNA Homo sapiens Melanoma melanoma tissue Regulation[miR-153-3p/Snail axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that circRNA_0084043 was significantly up-regulated in melanoma tissue, and the result was replicated in a larger sample size. Bioinformatics and luciferase reporter assays confirmed that circRNA_0084043 directly binds to miR-153-3p, and Snail is directly targeted by miR-153-3p. We also demonstrated that circRNA_0084043 may act as the sponge of miR-153-3p to up-regulate Snail expression, and consequently function as an oncogene in melanoma. High circRNA_0084043 expression was an independent risk factor of overall survival in melanoma patients. Yes circRNA_0084043 promotes melanoma cell proliferation, invasion and migration. 29777697 PCBP1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression [highly expressed] Western Blot//Transfection//Wound Healing Assay//qPCR//Survival Analysis//Microarray//Cell Proliferation Assay//Bioinformatics Analysis//Transwell Assay PCBP1-AS1 had significantly higher expression levels in cervical cancer tissues than in their normal counterparts (p < 0.001). Moreover, univariate analysis revealed that PCBP1-AS1 expression, tumor stage, pathologic T stage, and lymph vascular invasion were significantly correlated with the OS of cervical cancer patients Yes Collectively, these results suggest that the expression level of PCBP1-AS1 affected the proliferation, migration, and invasion of cervical cancer cells. 33833992 PCBP1-AS1 LncRNA Homo sapiens Glioma glioma cells Epigenetics [methylation ] Transfection//Migration Assay//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay Furthermore, we identified two lncRNAs termed PCBP1-AS1 and LINC02875 that may be involved in the malignant progression of glioma cells by using the TCGA database. Yes Loss-of-function assays confirmed that knockdown of PCBP1-AS1 and LINC02875 inhibited the proliferation, migration, and invasion of glioma cells. 33828990 PCBP1-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cells and tumor tissues Expression(lower expressed) qRT-PCR//Western Blot//Invasion Assay//Migration Assay ScRNA-seq analysis showed that PCBP1-AS1 and ZSCAN16-AS1 were significantly negatively correlated with most of the functional states of LUAD cells, especially with metastasis. Functionally, PCBP1-AS1 was aberrantly downregulated in LUAD cells and tumor tissues. Yes Knockdown of PCBP1-AS1 significantly promoted the migration and invasion of LUAD cells. Consistently, PCBP1-AS1 overexpression suppressed the metastasis of LUAD in vitro and in vivo.Besides, PCBP1-AS1 inhibition induced decreased E-cadherin expression and increased N-cadherin, Vimentin and Snail expression. 34107009 PGM5-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and adjacent normal tissues Regulation[ miR-466/PTEN axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//ChIP we collected 113 pairs of ESCC and adjacent normal tissues to conduct qRT-PCR analysis. The result showed that PGM5-AS1 was significantly downregulated in ESCC.Mechanistically, PGM5-AS1 was transcriptionally activated by p53 and it could directly interact with and sequester miR-466 to elevate PTEN expression, thereby inhibiting ESCC progression. In the present study, we found that PGM5-AS1 was frequently downregulated in ESCC tissues, plasma, and cell lines, and low PGM5-AS1 expression was positively correlated with poor differentiation, advanced tumor node metastasis (TNM) stage, and lymph node metastasis. Importantly, PGM5-AS1 was identified to be an effective diagnostic and prognostic biomarker for ESCC patients. Yes Functional experiments revealed that exogenous expression of PGM5-AS1 significantly suppressed the proliferation, migration, and invasion of ESCC cells in vitro as well as tumor growth in vivo. 31185143 PCAT29 LncRNA Homo sapiens Triple Negative Breast Neoplasms breast cancer tissues,cell lines Expression[lower expressed] qRT-PCR//MTT//Colony Formation Assay//Transwell Assay The expression of LncRNA PCAT29 was significantly suppressed in the breast cancer tissues and the triple-negative breast cancer cell lines. Yes PCAT29 overexpression caused inhibition of the proliferation rate and colony formation of the MDA-MB-231 cells. 32521844 hsa_circ_0039459 CircRNA Homo sapiens Liver Neoplasms hepatocellular carcinoma cells and tissues Interaction(miR-432/SYVN1) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay We found that circ-0039459 and SYVN1 mRNA were highly expressed, whereas miR-432 was lowly expressed in hepatocellular carcinoma cells and tissues.circ-0039459 targeted and regulated miR-432, which targeted and regulated SYVN1. The decreased miR-432 expression reversed the effects of circ-0039459 knockout in cancer cells. Furthermore, SYVN1 overexpression reversed the effect of miR-432 overexpression in hepatoma cells. Hence, circ-0039459 can affect the proliferation, apoptosis, migration, and invasion of hepatocellular carcinoma cells through the adsorption of miR-432, thereby regulating the expression of SYVN1. Yes After treatment with ribonuclease R or actinomycin D, the expression of linear RNA was reduced, whereas that of circular RNA was not significantly changed. circ-0039459 knockdown or miR-432 overexpression can inhibit cell proliferation, invasion, and migration and the expression of N-cadherin and vimentin proteins in carcinoma cells as well as promote apoptosis and increase the E-cadherin level. 35543347 circLRP6 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues regulation[ circ-LRP6/miR-182/Myc signaling ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ-LRP6 was significantly upregulated in ESCC tissues and correlated with malignant clinicopathological characteristics and poor prognosis. Therefore, our data indicate that circ-LRP6 is a novel oncogenic circRNA in ESCC, targeting the circ-LRP6/miR-182/Myc signaling may be a promising therapeutic approach for ESCC patients. Circ-LRP6 was significantly upregulated in ESCC tissues and correlated with malignant clinicopathological characteristics and poor prognosis. Yes Knockdown of circ-LRP6 evidently reduced ESCC cell viability, colony formation and invasion. 32867570 hsa_circ_0072088 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells interaction[Absorbing miR-377] qRT-PCR//FISH As a result, circ_0072088 was significantly overexpressed in ESCC tissues and cells, which was closely associated with tumor size, invasion depth, clinical stage, and lymph node metastasis of esophageal cancer.Mechanistically, circ_0072088 upregulated VEGF gene expression by acting as the sponge of miRNA-377. As a result, circ_0072088 was significantly overexpressed in ESCC tissues and cells, which was closely associated with tumor size, invasion depth, clinical stage, and lymph node metastasis of esophageal cancer. Yes circ_0072088 promoted ESCC cell proliferation, migration and invasion in vitro, and cell proliferation in vivo. 33061973 PMSB8-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and PC cell lines regulation[miR-382-3p/STAT1/PD-L1 axis] colony Formation Assay//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay PMSB8-AS1 expression was upregulated in PC tissues and cell lines and positively associated with the worst survival in patients with PC. lncRNA PMSB8-AS1 promotes pancreatic cancer progression via STAT1 by sponging miR-382-3p involving regulation PD-L1. PMSB8-AS1 expression was upregulated in PC tissues and cell lines and positively associated with the worst survival in patients with PC. Yes The in vitro and in vivo assays demonstrated that overexpression of PMSB8-AS1 significantly promoted pancreatic cancer cell proliferation, migration, and invasion, whereas knockdown of PMSB8-AS1 suppressed cell proliferation, migration, invasion, and EMT, and decreased apoptosis of PC cells. 32891166 PMS2P2 LncRNA Homo sapiens Osteoarthritis OA patient synovial fluid Interaction(miR-34a) CCK8//qRT-PCR//BrdU//MTT The results showed that PMS2L2 expression in OA patient synovial fluid was lower compared to that in control group fluid, and the extent of this reduction was related to disease stage. It was found that PMS2L2 over-expression caused increased miR-34a expression in OA patient chondrocytes but not in cells from healthy controls. In contrast, miR-34a over-expression in either cell population did not affect PMS2L2 expression. The results showed that PMS2L2 expression in OA patient synovial fluid was lower compared to that in control group fluid, and the extent of this reduction was related to disease stage. Yes Lastly, over-expression of both PMS2L2 and miR-34a led to inhibited chondrocyte proliferation. Of note, a combined over-expression of PMS2L2 and miR-34a resulted in stronger effects on proliferation compared to that from either single over-expression. 35930398 PMS2P2 LncRNA Homo sapiens gastric adenocarcinoma cancer tissues Expression[lower expressed] qRT-PCR//Transwell Assay The results revealed that PMS2L2 expression was downregulated in cancer tissues obtained from patients with GA compared with healthy adjacent tissues and was not significantly affected by clinical stage. Therefore, PMS2L2 may downregulate miR-25 expression to inhibit GA. Furthermore, low levels of PMS2L2 in cancer tissues were closely associated with a low overall 5-year survival rate in patients. Yes Furthermore, PMS2L2 overexpression inhibited the migration and invasion of GA cells. 32565974 circFoxo3 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma cell lines,ESCC tissues Regulation[miR-23a/PTEN axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot "In this study, circ-Foxo3 was lowly expressed in cell lines and ESCC tissues. Mechanically, we found a potential miRNA target, miR-23a, which negatively correlated with circ-Foxo3 in ESCC. Then, a luciferase assay confirmed the relationship between the circ-Foxo3 and miRNA. Moreover, circ-Foxo3 upregulation of PTEN occurred through ""sponging"" miR-23a." Yes Meanwhile, overexpression of circ-Foxo3 inhibited cell growth, migration, and invasion, whether in vivo or in vitro. 31680314 hsa_circ_0075829 CircRNA Homo sapiens Pancreatic Carcinoma PC clinical specimens and cell lines regulation[ circ_0075829/miR-1287-5p/LAMTOR3 axis] qRT-PCR//Luciferase Report Assay//FISH Compared with paracancerous tissues, the expression of circ_0075829 was increased in PC tissues, which was positively correlated with the clinical features of PC. Yes Knockdown of circ_0075829 significantly suppressed the proliferative, migratory and invasive rates of SW1990 and BxPC-3 cells both in vitro and in vivo. 33184989 circFOXO3 CircRNA Homo sapiens Liver Neoplasms liver cancer cells Regulation(PI3K/Akt Pathway) Transfection//Invasion Assay//Migration Assay circFOXO3 showed low expression in liver cancer cells; compared with the control group, the circFOXO3 expression and apoptosis rate of HuH-7 liver cancer cells in the circFOXO3 mimic group were significantly increased (P < 0.05) and the PI3K/Akt pathway-related protein expression, cell viability, invasion, and migration abilities were significantly reduced (P < 0.05); the apoptosis rate of HuH-7 liver cancer cells in the PI3K activator group was significantly reduced (P < 0.05) and the PI3K/Akt pathway related protein expression, cell viability, invasion and migration abilities were significantly increased (P < 0.05). Compared with the circFOXO3 mimic group, the apoptosis rate of HuH-7 liver cancer cells in the circFOXO3 mimic + PI3K activator group was significantly reduced (P < 0.05) and the PI3K/Akt pathway-related protein expression, cell viability, invasion and migration abilities were significantly increased (P < 0.05). Yes circFOXO3 showed low expression in liver cancer cells; compared with the control group, the circFOXO3 expression and apoptosis rate of HuH-7 liver cancer cells in the circFOXO3 mimic group were significantly increased (P < 0.05) and the PI3K/Akt pathway-related protein expression, cell viability, invasion, and migration abilities were significantly reduced (P < 0.05); the apoptosis rate of HuH-7 liver cancer cells in the PI3K activator group was significantly reduced (P < 0.05) and the PI3K/Akt pathway related protein expression, cell viability, invasion and migration abilities were significantly increased (P < 0.05). Compared with the circFOXO3 mimic group, the apoptosis rate of HuH-7 liver cancer cells in the circFOXO3 mimic + PI3K activator group was significantly reduced (P < 0.05) and the PI3K/Akt pathway-related protein expression, cell viability, invasion and migration abilities were significantly increased (P < 0.05). 35909586 hsa_circ_0066966 CircRNA Homo sapiens Liver Neoplasms HBV-positive liver cancer cells Expression(highly expressed) qRT-PCR//Transfection//MTT//migration assay Among them, hsa_circ_0066966 had the highest absolute Log2FC value and was abnormally increased in HBV-positive liver cancer cells. Yes Functional experiments further verified that knockdown of hsa_circ_0066966 had a significant inhibitory effect on the proliferation and migration of HBV-positive liver cancer cells. By contrast, overexpression of hsa_circ_0066966 in HBV-negative liver cancer cells resulted in the opposite effect. 34976133 circSIRT1 CircRNA Homo sapiens Cardiomegaly hiPSC-CMs Regulation(SIRT1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Co-IP//qRT-PCR//FISH//RIP//Luciferase Report Assay//ELISA//IF Our results showed that circ-SIRT1 (hsa_circ_0093884) expression was downregulated in Ang II-treated hiPSC-CMs, and confirmed that its conserved mouse homolog circ-Sirt1 (mmu_circ_0002354) was expressed at low levels in Ang II-treated H9c2 cells and TAC-induced mice model. Mechanistically, circ-SIRT1 could upregulate its host gene SIRT1 at the post-transcriptional level by sponging miR-3681-3p/miR-5195-3p and stabilized SIRT1 protein at the post-translational level by recruiting USP22 to induce deubiquitination on SIRT1 protein. Yes Functionally, circ-SIRT1/circ-Sirt1 attenuated Ang II-induced CH and induced autophagy in hiPSC-CMs and H9c2 cardiomyocytes. Further, SIRT1 knockdown could rescue the effect of circ-SIRT1 upregulation on Ang II-induced CH and autophagy in vitro and in vivo. 34759275 hsa_circ_0078710 CircRNA Homo sapiens Liver Neoplasms liver cancer tissues and cells. Interaction(miR-431-5p/TXNDC5 ) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Circ_0078710 and TXNDC5 were notably expressed in liver cancer tissues and cells.MiR-431-5p is the target of circ_0078710, and silence circ_0078710 can inhibit the malignant behavior and glycolysis of hepatocellular carcinoma (HCC) cells by releasing miR-431-5p. In addition, TXNDC5 was a target of miR-431-5p, and overexpression of TXNDC5 restored cell proliferation and glycolysis inhibition due to miR-431-5p. Yes Circ_0078710 knockdown diminished proliferation, migration, invasion and glycolytic metabolism of huh7 and Hep3B cells, and accelerated cell apoptosis. Animal experiments made clear the anti-tumor effect of circ_0078710 knockdown. 34606982 circDLC1 CircRNA Homo sapiens Liver Neoplasms HCC tissues Interaction(HuR and MMP1) In Vivo Experiment//RNA Pull-Down Our data demonstrated that circDLC1 was downregulated in HCC tissues and closely relevant to favorable prognosis. Mechanistic investigations revealed that circDLC1 could bind to RNA-binding protein HuR, which subsequently reduced the interaction between HuR and MMP1 mRNAs, and thus inhibited the expression of MMP1, ultimately contributing to inhibition of HCC progression. Yes Overexpression of circDLC1 inhibited the proliferation and motility of hepatoma cells in vitro and in vivo, while silencing of circDLC1 played the opposite role. 33391541 PLOD2 CircRNA Homo sapiens Colonic Neoplasms colon cancer tissue and cell lines Interaction(miR-513a-5p/SIX1/LDHA axis) colony Formation Assay//RNA Pull-Down//IHC//ChIP//Western Blot//ISH//Transfection//Colony Formation Assay//qRT-PCR//RIP//FISH//PCR//IP//Transwell Assay//IF Here, we found circPLOD2 was dramatically upregulated in colon cancer tissue and cell lines. Moreover, based on the analysis of RNA pull-down, RNA immunoprecipitation, luciferase and rescued assays, we confirmed that the interactions between circPLOD2, miR-513a-5p and SIX1. It suggested that circPLOD2 acted as a sponge of miR-513a-5p to regulate the activation of the target gene SIX1. Yes In vitro CCK-8, colony formation and transwell assays, and in vivo tumor transplantation assay were performed and explored that circPLOD2 might promote tumor proliferation, migration and invasion in vitro and in vivo. 36071678 PLIC11 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Interaction(YY1/PIWIL4 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay In our study, we found that PLIC11 was upregulated in lung cancer, particularly in metastatic lung cancer tissues. Mechanically, PLIC11 could interact with YY1 and promote PIWIL4 expression by transcription activation. Therefore, PLIC11 upregulation is a potential indicator of aggressive lung cancer, Silencing of PLIC11 has great potential therapeutic strategy in NSCLC. Yes Overexpression of PLIC11 enhanced cell proliferation, migration, and metastasis in vitro and in vivo. 36537719 circMEG3 CircRNA Homo sapiens Liver Neoplasms human liver cancer line Huh7 Expression [lower expressed] qRT-PCR//Colony Formation Assay//ChIP//Western Blot Herein, our results indicate that CircMEG3 is downregulated expression and negatively correlated with the expression of telomerase-related gene Cbf5 in human liver cancer. Moreover, CircMEG3 inhibits the expression of Cbf5, a component of telomere synthetase H/ACA ribonucleoprotein (RNP; catalyst RNA pseudouracil modification) through METTL3 dependent on HULC. Yes Moreover, CircMEG3 inhibits the growth of human liver cancer stem cells in vivo and in vitro. CircMEG3 inhibits the expression of m6A methyltransferase METTL3 dependent on HULC. Strikingly, increased Cbf5 abrogates the ability of CircMEG3 to inhibit malignant differentiation of human liver cancer stem cells. 33425489 hsa_circ_G004213 CircRNA Homo sapiens Liver Neoplasms Hepatic artery blood Interaction(miR‑513b‑5p/PRPF39) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay A novel gene was screened out; hsa‑circRNA‑G004213 (circ‑G004213) was significantly upregulated following TACE (fold change >10, P < 0.01). Further analysis found circ‑G004213 significantly increased the cisplatin sensitivity of HepG2 cells and positively associated with the prognosis of tumor‑bearing mice. It was demonstrated that circ‑G004213 regulated cisplatin resistance via the miR‑513b‑5p/PRPF39 axis. Yes Further analysis found circ‑G004213 significantly increased the cisplatin sensitivity of HepG2 cells and positively associated with the prognosis of tumor‑bearing mice. 33864660 PLEKHA8P1 LncRNA Homo sapiens Liver Neoplasms TCGA(418 samples including 369 primary tumor and 49 solid tissue normal samples) Expression [highly expressed] Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay PLEKHA8P1 Is Up-Regulated in HCC Samples and Predicts Unfavorable Prognosis in Patients from the TCGA-LIHC Dataset Yes PLEKHA8P1 Promotes Proliferation, Invasion and Migration in HCC Cells 34299245 PLCD3-OT1 LncRNA Homo sapiens Cataract lens capsule Interaction[miR-224-5p] Tunel//qRT-PCR//FISH//Luciferase Report Assay//RNA-seq The expression of lncRNA PLCD3-OT1 and PLCD3 were significantly decreased in ARC.In addition, PLCD3-OT1 may act as a ceRNA to regulate the expression of PLCD3 through competition for miR-224-5p. Yes PLCD3-OT1 overexpression promoted the expression of PLCD3, cell viability, proliferation, and inhibited cell apoptosis upon oxidative stress, while knockdown of PLCD3 showed the opposite results. 31725166 hsa_circ_0004771 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues regulation[miR-339-5p/CDC25A axis] qRT-PCR Here we profiled six pair plasma circRNA in ESCC based on RNA sequencing, and then verified the elevation of hsa_circ_0004771 in 20 cancer tissues and 105 pair case-control plasma samples by quantitative reverse transcriptase PCR.Mechanistically, hsa_circ_0004771 positively regulated CDC25A by acting as a molecular sponge of miR-339-5p and rescue assay confirmed this regulatory relationship. The upregulation of hsa_circ_0004771 was correlated with heavier tumor burden and poor prognosis, knockdown of it inhibited the ESCC cells proliferation both in vitro and in vivo. Yes The upregulation of hsa_circ_0004771 was correlated with heavier tumor burden and poor prognosis, knockdown of it inhibited the ESCC cells proliferation both in vitro and in vivo. 32050790 POLR1HASP LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells regulation[ miR-335-ROCK1 Axis] qRT-PCR//Luciferase Report Assay//RIP//Western Blot ZNRD1-AS1 expression was elevated in the NPC tissues and cells, and ZNRD1-AS1 overexpression was positively correlated with advanced TNM stage and the presence of lymph node metastasis. We provided evidence that ZNRD1-AS1 facilitates the invasion and metastasis of NPC cells via the miR-335-ROCK1 axis. ZNRD1-AS1 expression was elevated in the NPC tissues and cells, and ZNRD1-AS1 overexpression was positively correlated with advanced TNM stage and the presence of lymph node metastasis. Yes Our biological experiments indicated that ZNRD1-AS1 knockdown reduces NPC cell invasion and metastasis. 32547105 Platr4 LncRNA Mus musculus Non-alcoholic Fatty Liver Disease mouse liver Interaction(Nlrp3/ NF-κB signaling) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//qPCR//Co-IP//FISH//RIP//RNA-seq//Luciferase Report Assay//IF Cyclic expression of Platr4 is generated by the core clock component Rev-erbα via two RevRE elements (i.e., -1354/-1345 and -462/-453 bp). NF-κB transcriptionally drives Platr4 through direct binding to two κB sites (i.e., -1066/-1056 and -526/-516 bp), potentially accounting for up-regulation of Platr4 in experimental steatohepatitis.Platr4 functions to inactivate Nlrp3 inflammasome via intercepting NF-κB signaling. Yes Loss of Platr4 down-regulates Nlrp3 inflammasome activity in the liver, blunts its diurnal rhythm, and sensitizes mice to experimental steatohepatitis, whereas overexpression of Platr4 ameliorates the pathological conditions in an Nlrp3-dependent manner. 33391484 POU3F3 LncRNA Homo sapiens Triple Negative Breast Neoplasms breast cancer tissues Interaction[inactivating caspase 9] CCK8//qRT-PCR//ELISA//Western Blot In the present study we found that expression levels of lncRNA POU3F3 were higher in tumor tissues than in adjacent healthy tissues of triple negative breast cancer (TNBC) patients and were significantly and inversely correlated with levels of cleaved caspase 9 only in tumor tissues. In addition, plasma levels of lncRNA POU3F3 were higher in TNBC patients than in healthy controls and were significantly and inversely correlated with levels of cleaved caspase 9 only in TNBC patients. In addition, treatment of exogenous Cleaved Caspase-9 significantly attenuated the effects of lncRNA POU3F3 overexpression on cancer cell proliferation and apoptosis. lncRNA POU3F3 may promote proliferation and inhibit apoptosis of cancer cells in triple-negative breast cancer. Yes In addition, treatment of exogenous Cleaved Caspase-9 significantly attenuated the effects of lncRNA POU3F3 overexpression on cancer cell proliferation and apoptosis. 30843771 circTP63 CircRNA Homo sapiens lung squamous cell carcinoma LUSC tissues and adjacent nontumorous tissues Interaction[upregulating FOXM1] Western Blot//CCK8//qRT-PCR//RIP//Microarray By analyzing the co-expression network of differentially expressed circRNAs and dysregulated mRNAs, we identify that a cell cycle-related circRNA, circTP63, is upregulated in LUSC tissues and its upregulation is correlated with larger tumor size and higher TNM stage in LUSC patients. By analyzing the co-expression network of differentially expressed circRNAs and dysregulated mRNAs, we identify that a cell cycle-related circRNA, circTP63, is upregulated in LUSC tissues and its upregulation is correlated with larger tumor size and higher TNM stage in LUSC patients. Yes Elevated circTP63 promotes cell proliferation both in vitro and in vivo. 31324812 circLDLR CircRNA Homo sapiens Coronary Artery Disease coronary artery disease tissues Interaction(miR-26-5p/KDM6A Axis) qRT-PCR//Transfection//Cell Apoptosis Assay//Western Blot Downregulation of circLDLR was associated with increased miR-26-5p in coronary artery disease tissues. Moreover, the overexpression of KDM6A reduced VSMCs proliferation and increased apoptosis in an miR-26-5p/circLDLR axis-dependent manner. CircLDLR modulates the proliferation and apoptosis of VSMCs through miR-26-5p/KDM6A axis. Yes In addition, circLDLR could inhibit cell proliferation and promote cell apoptosis by regulating miR-26-5p. 35384910 POU6F2-AS1 LncRNA Homo sapiens Lung Neoplasms LADC tissues Interaction(miR-34c-5p/KCNJ4) Western Blot//Migration Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay//Transwell Assay High-regulation of POU6F2-AS1 was presented in LADC tissues compared with adjacent normal tissues, which was correlated with poor outcome of LADC patients. Collectively, POU6F2-AS1 might function as a ceRNA through sponging miR-34c-5p to high-regulate KCNJ4 in LADC, which indicates that POU6F2-AS1 might be a promising therapeutic target with significant prognostic value for LADC treatment. High-regulation of POU6F2-AS1 was presented in LADC tissues compared with adjacent normal tissues, which was correlated with poor outcome of LADC patients. Yes Functional experiments in Calu-3 and NCI-H460 cells showed that POU6F2-AS1 significantly promoted LADC cell proliferation, colony formation, invasion and migration. 33999092 POU3F3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[downregulating microRNA-30d-5p] qRT-PCR//Transwell Assay POU3F3 was upregulated, while miR-30d-5p was downregulated in cancer tissues than in adjacent healthy tissues of NSCLC patients. POU3F3 might positively regulate NSCLC cell proliferation, migration and invasion through downregulation of miR-30d-5p. Yes Overexpression of POU3F3 mediated enhanced proliferation, migration and invasion of NSCLC cells. 32615948 POU3F3 LncRNA Homo sapiens Carcinoma, Renal Cell tumor tissues Regulation(LncRNA GAS5) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Transwell Assay//IF In the present study, we found that POU3F3 was upregulated while GAS5 was downregulated in tumor tissues than that in adjacent healthy tissues of patients with RCC. In situ hybridization analysis showed that POU3F3 was mostly expressed in tumor tissues, while GAS5 was mostly expressed in adjacent healthy tissues. Overexpression of POU3F3 mediated the downregulation of GAS5 in RCC cells, while GAS5 overexpression failed to significantly affect POU3F3 expression. Overexpression of POU3F3 led to promoted, while GAS5 overexpression led to inhibited proliferation, migration, and invasion of RCC cells. In addition, GAS5 overexpression attenuated the enhancing effects of POU3F3 overexpression on cancer cell proliferation, migration, and invasion. High level of POU3F3 and low level of GAS5 were closely correlated with poor prognosis of RCC patients. Expression levels of POU3F3 and GAS5 were significantly and inversely correlated in tumor tissues but not in adjacent healthy tissues of RCC patients. Yes Overexpression of POU3F3 mediated the downregulation of GAS5 in RCC cells, while GAS5 overexpression failed to significantly affect POU3F3 expression. Overexpression of POU3F3 led to promoted, while GAS5 overexpression led to inhibited proliferation, migration, and invasion of RCC cells. In addition, GAS5 overexpression attenuated the enhancing effects of POU3F3 overexpression on cancer cell proliferation, migration, and invasion. 34352801 POU3F3 LncRNA Homo sapiens Osteoarthritis OA patients/animal cartilage tissues, chondrocyte model Interaction(miR-29a- 3p/FOXO3 Axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//ELISA The expression level of POU3F3 was decreased in OA patients/animal cartilage tissues and IL-1β-stimulated in vitro chondrocyte model. Mechanistically, Luciferase reporter and RNA immunoprecipitation (RIP) assays indicated that miR-29a-3p could directly bind to POU3F3, and FOXO3 was a target gene of miR-29a-3p. Functional rescue assays confirmed this POU3F3/miR-29a-3p/FOXO3 axis in chondrocytes during OA occurrence. Yes POU3F3 overexpression inhibited IL-1β-induced injury of chondrocytes, enhancing cell viability, suppressing apoptosis and inflammatory cytokine secretion, rescuing metabolic dysfunction, and restraining autophagy in vitro. Furthermore, intraarticularly delivery of lentivirus containing POU3F3 alleviates the damage in mouse OA model in vivo. 35264092 POU3F3 LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues and cell lines Expression[highly expressed] qRT-PCR Our results suggested that levels of linc-POU3F3 were dramatically increased in hepatocellular carcinoma tissues and cell lines compared with paired normal hepatic tissues and normal hepatic cell line, respectively. Levels of linc-POU3F3 were positively correlated with clinical stage, tumor size, vascular invasion and metastasis. Yes The gain- and loss-of-function experiments showed that linc-POU3F3 expression significantly promoted tumor cell proliferation, migration and invasion. 29906746 POU3F3 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissue,cell line Interaction[miR-127-5p/FOXD1] ChIP//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay POU3 F3 was validated to be up-regulated in the cervical cancer tissue specimens and cells comparing with normal controls. The transcriptional expression of POU3 F3 was activated by the transcription factor SP1. Mechanically, POU3 F3 acted as the sponge to target miR-127-5p, while miR-127-5p bind with the 3'-UTR of FOXD1 gene. In conclusion, our data verifies that lncRNA POU3 F3, induced by transcription factor SP1, acts as an oncogene in the cervical cancer tumorigenesis via regulating miR-127-5p/FOXD1 axis, providing a possible therapeutic target for cervical cancer. Yes In vitro, POU3 F3 promoted the proliferation, invasion of cervical cancer cells. In vivo, POU3 F3 knockdown repressed the tumor growth of cervical cancer cells. 31252264 POU3F3 LncRNA Homo sapiens Nasopharyngeal carcinoma blood Interaction[TGF-β1] Western Blot//Migration Assay//qRT-PCR//ELISA//Invasion Assay Our study showed that plasma levels of lncRNA POU3F3 and TGF-β1 (transforming growth factor-β) were both increased in nasopharyngeal carcinoma patients than in healthy controls.TGF-β1 inhibitor partially rescued the inhibited cancer cell migration and invasion caused by lncRNA POU3F3 overexpression. LncRNA POU3F3 overexpression led to down-regulated TGF-β1 expression, while exogenous TGF-β1 and TGF-β1 inhibitor treatment did not significantly change the expression level of lncRNA POU3F3. Therefore, lncRNA POU3F3 may promote cancer cell migration and invasion in nasopharyngeal carcinoma by up-regulating TGF-β1. Plasma levels of lncRNA POU3F3 were not affected by the diameter of primary tumors but increased in patients with tumor metastasis. Follow-up study showed that high plasma levels of lncRNA POU3F3 were significantly correlated with poor overall survival. Yes LncRNA POU3F3 overexpression and exogenous TGF-β1 treatment led to promoted, while TGF-β1 inhibitor led to inhibited migration and invasion of nasopharyngeal carcinoma cells. 30602452 POLR1HASP LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues,cell lines regulation[regulating miR-194 and ZEB1] CCK8//qRT-PCR//Transwell Assay//Western Blot Zinc ribbon domain containing 1 antisense RNA 1level was upregulated in BC. Knockdown of ZNRD1-AS1 suppressed BC cell development in vitro and in vivo via targeting miR-194 to regulate ZEB1, indicating a novel avenue for treatment of BC. Yes ZNRD1-AS1 silence repressed proliferation, migration, invasion and EMT in BC cells. 32862492 POU3F3 LncRNA Homo sapiens Melanoma melanoma tissues Regulation(lncRNA MEG3) qRT-PCR//Invasion Assay We found that POU3F3 was upregulated, while lncRNA MEG3 was downregulated in melanoma. Expression levels of POU3F3 and MEG3 were inversely correlated across tumor tissues. Yes In vitro experiments showed that POU3F3 overexpression decreased MEG3 expression in melanoma cells, while MEG3 overexpression failed to affect POU3F3. POU3F3 overexpression increased melanoma cell proliferation, while MEG3 overexpression decreased melanoma cell proliferation. In addition, rescue experiments showed that MEG3 overexpression attenuated the enhancing effects of POU3F3 overexpression. 35201451 POU3F3 LncRNA Homo sapiens prostate carcinoma prostate carcinoma tissues Interaction[upregulating rho-associated protein kinase 1 ] CCK8//qRT-PCR//Western Blot Expression levels of POU3F3 increased with increase in the diameter of tumor but were not significantly affected by lymph node metastasis or distant metastasis.Expression levels of POU3F3 and ROCK1 were positive correlated in tumor tissues but not in adjacent healthy tissues. POU3F3 and ROCK1 overexpression promoted, while ROCK1 knockdown inhibited the proliferation of prostate carcinoma cells. ROCK1 knockdown reduced the enhancing effect of POU3F3 overexpression on cancer cell proliferation. POU3F3 overexpression led to ROCK1 overexpression in prostate carcinoma cells, while ROCK1 overexpression did not significantly affect POU3F3 expression. Yes POU3F3 and ROCK1 overexpression promoted, while ROCK1 knockdown inhibited the proliferation of prostate carcinoma cells. ROCK1 knockdown reduced the enhancing effect of POU3F3 overexpression on cancer cell proliferation. 30474879 POT1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC cells Interaction(miR-497-5p/PDK3 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay In this study, high POT1-AS1 expression in GC cells was confirmed, and its elevated expression was linked to patients’ negative clinicopathological characteristics, as well as shorter disease-free survival (DFS) and overall survival (OS). POT1-AS1 was shown to serve as a competing endogenous RNA (ceRNA) by sponging miR-497-5p to increase PDK3 expression. In this study, high POT1-AS1 expression in GC cells was confirmed, and its elevated expression was linked to patients’ negative clinicopathological characteristics, as well as shorter disease-free survival (DFS) and overall survival (OS). Yes The impact of POT1-AS1 silencing on GC malignant phenotypes could be reversed by suppressing miR-497-5p or restoring PDK3, according to rescue experiments. 35070402 circROBO2 CircRNA Homo sapiens Coronary Artery Disease HASMCs Interaction(Circ_ROBO2/miR-149 Axis) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay The expression patterns of circ_ROBO2 and miR-149 in CAD patients and PDGF-BB-treated human aortic smooth muscle cells (HASMCs) were upregulated and downregulated, respectively. Knockdown of circ_ROBO2 could markedly inhibit the capabilities of proliferation and migration, enhance the apoptotic rate, and suppress NF-κB signaling in PDGF-BB-treated HASMCs. Mechanistically, circ_ROBO2 acted as a sponge of miR-149 to activate TRAF6/NF-κB signaling. Rescue studies demonstrated that neither silencing miR-149 nor activation of NF-κB signaling obviously abolished the biological roles of circ_ROBO2 knockdown in PDGF-BB treated-HASMCs. Yes Knockdown of circ_ROBO2 could markedly inhibit the capabilities of proliferation and migration, enhance the apoptotic rate, and suppress NF-κB signaling in PDGF-BB-treated HASMCs. 34649241 POSTN CircRNA Homo sapiens Myocardial Infarction blood regulation[miR-96-5p/BNIP3 Axis] qRT-PCR//Western Blot//PCR//IF We identified that the expression of circPostn was elevated in the plasma of MI patients, MI mouse model, and hypoxia and reoxygenation (H/R)-treated human cardiomyocytes.Thus, we conclude that circPostn contributes to MI-induced myocardial injury and cardiac remodeling by regulating miR-96-5p/BNIP3 axis. Yes The depletion of circPostn significantly attenuated MI-related myocardium injury and reduced the infarct size in MI mouse model. 33681183 Postn CircRNA Mus musculus Myocardial Infarction ventricular tissues of mice Regulation(miR-96-5p/BNIP3 Axis) Western Blot//RIP//PCR//IP//IF The depletion of circPostn was able to decrease MI-induced expression of collagen 1α1 and collagen 3α1 in the ventricular tissues of mice. The protein expression of collagen and α-smooth muscle actin (SMA) was up-regulated in MI mice and was inhibited by circPostn knockdown. Meanwhile, the expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) was repressed by circPostn depletion in the ventricular tissues of MI mice. Besides, the circPostn depletion attenuated cardiomyocyte apoptosis in mice. Mechanically, circPostn served as a miR-96-5p sponge and miR-96-5p-targeted BNIP3 in human cardiomyocytes, in which circPostn up-regulated BNIP3 expression by targeting miR-96-5p. circPostn promoted H/R-induced cardiomyocyte injury by modulating miR-96-5p/BNIP3 axis. Thus, we conclude that circPostn contributes to MI-induced myocardial injury and cardiac remodeling by regulating miR-96-5p/BNIP3 axis. Our finding provides new insight into the mechanism by which circPostn regulates MI-related cardiac dysfunction. circPostn, miR-96-5p, and BNIP3 are potential targets for the treatment of MI-caused heart injury. Yes The circPostn knockdown obviously enhanced left ventricular ejection fraction (LVEF) and left ventricular fraction shortening (LVFS) and inhibited left ventricular anterior wall thickness at diastole (LVAWd) and left ventricular posterior wall thickness at diastole (LVPWd). 33681183 hsa_circ_0001006 CircRNA Homo sapiens Cardiomegaly cardiac hypertrophy mice and cardiomyocytes Interaction(miR-214-3p/PAK6 axis) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Microarray In this report, we found that circular RNA hsa_circ_0001006 (circ_0001006) was upregulated in cardiac hypertrophy mice and cardiomyocytes treated with angiotensin II (Ang II).Our data demonstrated that circRNA_0001006 exacerbates cardiac hypertrophy via suppressing miR-214-3p leading to enhanced PAK6 levels. Yes Next, we noticed that gain of function circ_0001006 could induce cardiomyocyte hypertrophy; oppositely, knockdown of circ_0001006 remitted Ang II-induced cardiomyocyte hypertrophy. 35306484 POLR1HASP LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction( miR-9-5p/HSP90AA1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//FISH//qRT-PCR//migration assay//Luciferase Report Assay//H&E Staining In this study, we found that ZNRD1-AS1 levels were significantly upregulated in gastric cancer tissues compared to those in adjacent healthy gastric tissues. ZNRD1-AS1 knockdown suppressed tumor growth and pulmonary metastasis in a nude mouse model ZNRD1-AS1 can bind to miR-9-5p and ZNRD1-AS1 knockdown can decrease the protein level of heat shock protein 90 alpha family class A member 1 (HSP90AA1), which is the target of miR-9-5p. ZNRD1-AS1 levels were correlated with lymph node metastasis, distal metastasis, and TNM stage, but were not correlated with age and sex. Yes ZNRD1-AS1 knockdown suppressed cell proliferation, migration, and invasion, and promoted apoptosis. ZNRD1-AS1 overexpression had the opposite effect. 34226297 circCSPP1 CircRNA Homo sapiens Liver Neoplasms cell lines Interaction(miR-1182) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircCSPP1 knockdown inhibited the proliferation, migration and invasion while promoted apoptosis of liver cancer cells. Mechanically, we predicted and verified the target miR of circCSPP1 which is miR-1182. miR-1182 was capable of reversing the effect of circCSPP1 on liver cancer cells. Yes CircCSPP1 knockdown inhibited the proliferation, migration and invasion while promoted apoptosis of liver cancer cells. Mechanically, we predicted and verified the target miR of circCSPP1 which is miR-1182. miR-1182 was capable of reversing the effect of circCSPP1 on liver cancer cells. 33935503 hsa_circ_0000105 CircRNA Homo sapiens Liver Neoplasms liver cancer tissues and cell lines regulation[miR-498/PIK3R1] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry Circ_0000105 was highly expressed in liver cancer tissues and cell lines.Circ_0000105 plays a cancer-promoting role in liver cancer by regulating the miR-498/PIK3R1 axis. Moreover, its high expression was associated with an increase in the T stage of liver cancer patients and a low degree of tumor differentiation. Yes Circ_0000105 overexpression promoted liver cancer cell proliferation and inhibited apoptosis, whereas knocking down circ_0000105 triggered the opposite effect. 32729955 PGM5P4-AS1 LncRNA Homo sapiens Lung Neoplasms  Lung cancer tissues  Expression [lower expressed] Wound Healing Assay//qRT-PCR//MTT//Cell Cycle Assay//Transwell Assay In this work, we found that a newly discovered lncRNA, lncRNA PGM5P4-AS1, was lower expressed in lung cancer tissues than adjacent tissues. Then, the lncRNA PGM5P4-AS1 was overexpressed or knocked-down in different lung cancer cells, and its effects on the malignant phenotypes were measured by 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, cell cycle assay, wound healing assay, and transwell assay. Further, the growth of lung cancer tumors in nude mice was also inhibited by PGM5P4-AS1 overexpression. In mechanism, PGM5P4-AS1 has the binding site of miR-1275 and could positively regulate the expression of LZTS3 via sponging miR-1275. Yes The results showed that the overexpression of PGM5P4-AS1 inhibited lung cancer cell proliferation, migration, and invasion activities, while these abilities were prominently promoted by the interference of PGM5P4-AS1. 33315502 PICSAR LncRNA Homo sapiens pancreatic ductal adenocarcinoma cell lines regulation[RelA/p65] qRT-PCR//RNA-seq These data were validated in several PDAC cell lines, and significant upregulation of LINC00162 was found in all of them. Furthermore, the result of Chromatin immunoprecipitation assay revealed that RelA/p65 directly bound to LINC00162, and the expression of LINC00162 in PDAC decreased after RelA/p65 knock-down, the proliferation ability of AsPc-1 also significantly inhibited after knocking down LINC00162 and RelA/p65 simultaneously, indicating that RelA/p65 directly involve in the transcriptional regulation of LINC00162. Yes Knock-down of LINC00162 significantly inhibited the proliferation, colony formation and migration of PATC cells in vitro and suppressed the growth of PATC xenografts in vivo. 32364285 hsa_circ_0043265 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and cell lines (SCC25, SCC15, SCC9 and Cal27) Interaction(miR-1243/SALL1 Axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay the current study demonstrated that circ_0043265 was downmodulated in TSCC and was identified as a ceRNA that restrained the cell proliferation, migration and invasion of SCC25 and Cal27 cells via modulating the miR-1243/SALL1 axis. Yes Functionally, circ_0043265 overexpression led to an attenuation of cell proliferation, migration and invasion of SCC25 and Cal27 cells. 34257535 PINK1-AS LncRNA Homo sapiens Small Cell Lung Carcinoma SCLC tissues Expression(highly expressed) Transfection//qPCR//Transwell Assay We found that PINK1-AS was upregulated in SCLC tissues compared to that in non-cancer tissues. Plasma expression levels of PINK1-AS were increased in SCLC patients compared to that in the controls. High plasma expression levels of PINK1-AS were closely associated with worse survival. Plasma expression of PINK1-AS was only closely correlated with distant tumor metastasis, but not other factors. High plasma expression levels of PINK1-AS effectively separated patients with distant metastasis from non-metastatic patients. Yes Moreover, PINK1-AS positively regulated the migration and invasion of SCLC cells. 35764723 PILAR1 LncRNA Homo sapiens Adenocarcinoma of Lung Expression[Expression[highly expressed]-expression] qRT-PCR The expression of PILAR1 in Dhanasekaran et al. and TCGA cohorts is shown in Fig. 1 D and E. Further, to examine the diagnostic ability of PILAR1 in discriminating LUAD patients from normal lung samples, ROC analysis was performed. The Area Under Curve (AUC) obtained for samples from the TCGA cohort was 0.95, and Dhanasekaran et al. cohort was 0.89, suggesting its potential in diagnosis of LUAD patients (Fig. 1 F). We utilised GTEx data to explore the expression of PILAR1 in normal human tissues. Interestingly, expression of PILAR1 was limited to skin, and testis (Fig. 1 G). Further, we explored the expression of PILAR1 in human cancer using MiPanda database. Interestingly, PILAR1 was overexpressed in almost all the cancer types compared to the normal counterpart (SExpression[up-expression]plementary Fig. S1 D). These results suggest that PILAR1 is a cancer-specific LncRNA with very restricted expression in normal samples. Further, we performed the Kaplan-Meier analysis of PILAR1 in Dhanasekaran et al. and TCGA cohorts. As expected, in both the cohorts, patients with high PILAR1 expression showed significantly poor survival (Dhanasekaran et al. cohort: HR = 2.29, p-value = 0.017 and TCGA cohort: HR = 1.51 and p-value = 0.017) (Fig. 1H and I). Furthermore, we utilised microarray datasets available on KM Plotter database to perform the Kaplan-Meier analysis in lung cancer samples (Affy id- 237563_s_at). Interestingly, PILAR1 significantly predicted the survival in KM-plotter datasets as well (HR = 2.67, p-value < 0.0001) (Fig. 1 J). In a multivariate analysis, PILAR1 predicted the survival independent of all clinical factors (SExpression[up-expression]plementary Fig. S1 E). Yes In vitro, we showed that lncRNA AK001796 knockdown markedly sExpression[up-expression]pressed cell proliferation and cell invasion abilities. 30639423 hsa_circ_0000003 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and cell lines, Interaction(miR‑330‑3p/GLS axis) RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis Here, we found that circ_0000003 expression was upregulated in TSCC tissues and cell lines, and high circ_0000003 expression was correlated with advanced TNM stage, increased tumor size and poor patient survival. Mechanistically, we found that circ_0000003 acted as a competing endogenous RNA (ceRNA) that sponged miR‑330‑3p, thereby elevating glutaminase (GLS) expression. Accordingly, cell invasion, migration, glutamine consumption, α‑ketoglutarate (α‑KG) production and ATP production were significantly decreased by circ_0000003 knockdown in TSCC cells, and these effects were reversed by miR‑330‑3p inhibition. Here, we found that circ_0000003 expression was upregulated in TSCC tissues and cell lines, and high circ_0000003 expression was correlated with advanced TNM stage, increased tumor size and poor patient survival. Yes Circ_0000003 was revealed to facilitate cell proliferation, migration and invasion of TSCC cells. 33649795 PIK3CD-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[binding with microRNA-566] RNA Pull-Down//Western Blot//Transwell Assay//CCK8//FISH//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining//IF LncRNA PIK3CD-AS1 was downregulated in HCC tissues and cells, and mainly located in cytoplasm.Collectively, our study suggests that the expression of PIK3CD-AS1 was down-regulated in HCC, and overexpression of PIK3CD-AS1 promoted the expression of LATS1 by competitive binding of miR-566 to inhibit the growth, invasion and metastasis of HCC cells. Yes Overexpression of PIK3CD-AS1 inhibited proliferation, colony formation, invasion, migration, epithelial-mesenchymal transition (EMT) and cell cycle progression and promoted apoptosis of HCC cells. Overexpression of PIK3CD-AS1 decreased the growth rate and weight of xenograft tumor in nude mice PIK3CD-AS1 competitively combined with miR-566 to regulate expression of LAST1. 31624469 circCLK3 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and cell lines Interaction(miR-455-5p/PARVA axis) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay In the present study, our findings revealed the upregulated expression of circCLK3 in TSCC tissues and cell lines.Moreover, circCLK3 acted as a molecular sponge for miR-455-5p. PARVA was the target gene of miR-455-5p. Furthermore, the negative correlation between expression of miR-455-5p and circCLK3 or PARVA in TSCC tissues was discovered. Rescue assays indicated that PARVA overexpression reversed the circCLK3 knockdown-mediated inhibitory effects on the progression of TSCC. Yes CircCLK3 knockdown suppressed cell proliferation, migration invasion, and induced cell cycle arrest at G0/G1 phase in TSCC. 33655541 PICSAR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[PI3K/AKT/mTOR signaling pathway] IHC//Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining In the present study, we found that PICSAR was upregulated in HCC tissues and cells and correlated with progression and poor prognosis in HCC patients.PICSAR played an oncogenic role by targeting miR-588 and subsequently promoted EIF6 expression and PI3K/AKT/mTOR activation in HCC. In the present study, we found that PICSAR was upregulated in HCC tissues and cells and correlated with progression and poor prognosis in HCC patients. Yes Gain- and loss-of-function experiments indicated that PICSAR enhanced cell proliferation, colony formation, and cell cycle progression and inhibited apoptosis of HCC cells. 32860321 PICSAR LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer cells and tissues interaction[binding THRAP3] Flow Cytometry//qRT-PCR//RNA Pull-Down//RIP Here, we reported that LINC00162, a super-enhancer long noncoding RNA, was highly expressed in bladder cancer cells and tissues.Finally, we demonstrated a mechanism that LINC00162 could regulate PTTG1IP expression through binding THRAP3. Yes Knocking down LINC00162 expression can inhibit the proliferative activity of bladder cancer cells and the growth of transplanted tumors in vivo, while knocking down the expression of PTTG1IP could restore the proliferative activity of bladder cancer cells. 33344916 PICSAR LncRNA Homo sapiens Skin Neoplasms CSCC tissues and cells regulation[miR-125b/YAP1 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay PICSAR was upregulated in CSCC tissues and cells.PICSAR knockdown suppressed cell proliferation and invasion and promoted apoptosis in CSCC cells by regulating miR-125b/YAP1 axis, providing new sights for treatment of CSCC. Yes PICSAR knockdown inhibited cell proliferation and invasion and induced apoptosis in CSCC cells. 32841663 PINK1-AS LncRNA Homo sapiens Stomach Neoplasms human GC Interaction(microRNA-200a) In Vivo Experiment//ISH//FISH//Luciferase Report Assay//IHC The expression of miR-200a was downregulated in human GC, correlating with upregulation of a novel miR-200a-targeting long non-coding RNA (LncRNA), PINK1 (PTEN Induced Kinase 1)-AS.RNA immunoprecipitation, RNA-pull down, and RNA fluorescence in situ hybridization assays confirmed that PINK1-AS directly binds to miR-200a. Yes Silencing PINK1-AS in GC cells led to miR-200a accumulation, Gαi1 downregulation, and inhibition of GC cell progression in vitro, whereas PINK1-AS upregulation produced the converse results. Significantly, anti-GC cell activity induced by PINK1-AS shRNA was ameliorated by the expression of miR-200a antisense or the 3'-UTR (untranslated region)-depleted Gαi1. In vivo, the growth of subcutaneous MGC-803 xenografts in nude mice was inhibited by PINK1-AS shRNA, but accelerated by PINK1-AS overexpression. Patient-derived GC xenograft growth in nude mice was largely inhibited after intratumoral injection of PINK1-AS shRNA lentivirus. 33958720 PICART1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and normal tissues,cell lines (HGC27, BGC823, SGC7901, MGC803) Regulation[PI3K/AKT and ERK/MAPK signaling pathways] CCK8//qRT-PCR//Western Blot LncRNA-PICART1 was lowly expressed in both GC tissues and cell lines.The regulation of the PI3K/AKT and ERK/MAPK signaling pathways might be the underlying mechanism of the tumor suppressor role of lncRNA-PICART1. Yes lncRNA-PICART1 significantly suppressed cell proliferation, whereas promoted cell apoptosis. 30720166 PICART1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell Regulation[AKT1 signaling pathway] qRT-PCR//MTT//Western Blot In addition, PICART1 expression was down-regulated in NSCLC cell lines. These results suggested that overexpression of PICART1 suppressed cell growth and invasion partly through regulating AKT signaling pathway in NSCLC. Yes Overexpression of PICART1 inhibited NSCLC cell growth and induced cell cycle arrest at G2/M phase. Elevated expression of PICART1 suppressed NSCLC cell colony formation and cell invasion. 30662662 PICART1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell lines Regulation[ JAK2/STAT3 signaling] Flow Cytometry//qRT-PCR//MTT//Transwell Assay PICART1 expression was down-regulated in human lung cancer tissues and cell lines. Additionally, PICART1 acts as a tumor suppressor may be via regulation of JAK2/STAT3 pathway. Yes Knockdown of PICART1 increased cell viability of lung cancer cell lines. 29940776 PICART1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines regulation[upregulating TCF21] qRT-PCR//RIP//ChIP PICART1 was downregulated in CC tissues and cell lines.lncRNA PICART1 recruits ARID1A to activate TCF21 expression, thus alleviating the malignant progression of CC. CC patients with worse TNM staging and larger tumor size presented lower level of PICART1. Low level of PICART1 in CC patients predicted a worse prognosis. Yes Silence of PICART1 stimulated the proliferative, migratory and invasive abilities of HeLa and SiHa cells. 32382324 PHAROH LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma and mouse embryonic stem cells Regulation(TIAR) qRT-PCR We identified a long non-coding RNA, Gm19705, that is overexpressed in hepatocellular carcinoma and mouse embryonic stem cells. RNA-seq analysis of PHAROH knockouts revealed that a large number of genes with decreased expression contain a Myc motif in their promoter. Yes We named this RNA Pluripotency and Hepatocyte Associated RNA Overexpressed in HCC, or PHAROH. Depletion of PHAROH impacts cell proliferation and migration, which can be rescued by ectopic expression of PHAROH. 34002693 PHACTR2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[ERK- and AKT/GSK-3β-Signaling Pathways] RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//FISH//RIP//MTT//Cell Cycle Assay//Colony Formation Assay//Invasion Assay//Transwell Assay lncIHS was overexpressed in HCC and decreased the survival rate of HCC patients.Moreover, results from transcriptome-sequencing analysis and mass spectrometry showed that lncIHS regulated multiple genes that were the upstream molecules of the ERK- and AKT-signaling pathways. lncIHS was overexpressed in HCC and decreased the survival rate of HCC patients. Yes Knockdown of lncIHS inhibited HCC cell migration, invasion, and proliferation, and vice versa. 31128422 PHACTR2-AS1 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues Expression[highly expressed] qRT-PCR In the present study, we investigated the biological role of PHACTR2-AS1 in tongue squamous cell carcinoma (TSCC). PHACTR2-AS1 was preferentially localized in the cytoplasm, and was notably upregulated in TSCC tissues. High PHACTR2-AS1 was correlated with tumour differentiation, metastatic clinical features, relapse and shortened survival time. Yes Depletion of PHACTR2-AS1 did not affect TSCC cell viability and colony formation ability, whereas substantially inhibited cell migration and invasion in vitro and lung metastasis in vivo. 32702100 hsa_circ_0002162 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC cell lines & SCC-9 cells Interaction(miR-33a-5p) Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Invasion Assay Hsa_circ_0002162 expression was increased in human TSCC cell lines SCC-9, CAL-27, HSC-4, and SCC-25 compared with HOK. In CAL-27 cells, hsa_circ_0002162 knockdown inhibited cell proliferation and invasion and promoted apoptosis. In SCC-9 cells, hsa_circ_0002162 overexpression enhanced cell proliferation and invasion and suppressed apoptosis. Furthermore, a negative regulation of hsa_circ_0002162 on miR-33a-5p (but not miR-302b-5p and miR-545-5p) was observed. In the rescue experiment, miR-33a-5p knockdown increased cell proliferation and invasion, and decreased apoptosis in hsa_circ_0002162 knockdown-treated CAL-27 cells, whereas miR-33a-5p overexpression decreased cell proliferation and invasion, but increased apoptosis in hsa_circ_0002162 overexpression-treated SCC-9 cells. The luciferase reporter assay showed the direct binding of hsa_circ_0002162 to miR-33a-5p. Yes In CAL-27 cells, hsa_circ_0002162 knockdown inhibited cell proliferation and invasion and promoted apoptosis. In SCC-9 cells, hsa_circ_0002162 overexpression enhanced cell proliferation and invasion and suppressed apoptosis. Furthermore, a negative regulation of hsa_circ_0002162 on miR-33a-5p (but not miR-302b-5p and miR-545-5p) was observed. 33729388 PINT87aa LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell Interaction(FOXM1/PHB2) qRT-PCR PINT87aa was significantly increased in the hydrogen peroxide-induced HCC cell senescence model. In contrast, FOXM1 gain-of-function could partially reduce the proportion of senescent HCC cells and enhance mitophagy. PINT87aa overexpression did not affect the expression of FOXM1 itself but reduced that of its target genes involved in cell cycle and proliferation, especially PHB2, which was involved in mitophagy and transcribed by FOXM1. Structural analysis indicated that PINT87aa could bind to the DNA-binding domain of FOXM1, which was confirmed by co-immunoprecipitation and immunofluorescence co-localization. Yes Overexpression of PINT87aa induced growth inhibition, cellular senescence, and decreased mitophagy in vitro and in vivo. 33754036 PLACT1 LncRNA Homo sapiens Pancreatic Neoplasms tumor tissues regulation[NF-κB signaling pathway] ISH//qRT-PCR We identified a novel lncRNA-PLACT1, which was significantly upregulated in tumor tissues and correlated with progression and poor survival in PDAC patients.Our findings suggest that PLACT1 provides a novel epigenetic mechanism involved in constitutive activation of NF-κB signaling pathway and may represent a new therapeutic target of PDAC. We identified a novel lncRNA-PLACT1, which was significantly upregulated in tumor tissues and correlated with progression and poor survival in PDAC patients. Yes Moreover, PLACT1 promoted the proliferation and invasion of PDAC cells in vitro. 32085715 PITPNA-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(miR-92a-3p) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//Flow Cytometry//Transwell Assay The results of high throughput chip analysis identified that PITPNA-AS1 was up-regulated in GC tissues. Meanwhile, PITPNA-AS1 could regulate SOX4 expression via targeting miR-92a-3p. Yes Our data revealed that knockdown of PITPNA-AS1 was able to inhibit tumor development of GC cells. Meanwhile, PITPNA-AS1 could regulate SOX4 expression via targeting miR-92a-3p. 34496348 PLAC45 LncRNA Homo sapiens Stomach Neoplasms gastric tissues,GC cells regulation[down-regulating C-Myc] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Transwell Assay The expression level of PLAC2 was downregulated in 38 out of 45 cases of GC tissues compared with that in normal gastric tissues, and it also declined in GC cells. LncRNA PLAC2 affects the biological behaviors of GC cells by regulating the expression of c-Myc gene. Yes The results of flow cytometry showed that after overexpression of PLAC2, the cell cycle was arrested in the G1/G0 phase, and the apoptosis rate was increased. 33336736 PLA2G2C LncRNA Homo sapiens Colonic Neoplasms COAD tissues Interaction(miR-515-5p/SLIT3 axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//migration assay//Luciferase Report Assay//Cell Proliferation Assay The results showed that UBXN10-AS1 and SLIT3 were expressed at low levels in COAD tissues, while miR-515-5p was expressed at high levels. The luciferase reporter and RNA RIP assays demonstrated that UBXN10-AS1 targeted miR-515-5p, which in turn targeted SLIT3. Functionally, miR-515-5p overexpression reversed the inhibition of COAD cell proliferation and migration by UBXN10-AS1 overexpression, and SLIT3 overexpression counteracted the oncogenicity of miR-515-5p. Yes UBXN10-AS1 overexpression suppressed tumor growth in vitro and in vivo. 35034539 hsa_circ_0091579 CircRNA Homo sapiens Liver Neoplasms LCa tissues,cell lines Interaction[regulating microRNA-490-3p ] CCK8//qPCR//Luciferase Report Assay//Transwell Assay circ_0091579 was highly expressed in HCC and HCC cells. Bioinformatics software predicted the binding sites between circ_0091579 and microRNA-490-3p, and dual-luciferase reporter gene assay confirmed the binding relationship between circ_0091579 and microRNA-490-3p. qPCR results showed that microRNA-490-3p was remarkably down-regulated in LCa tissues. In vitro experiments confirmed that overexpression of microRNA-490-3p inhibited the proliferative ability and metastasis of HCC cells. Yes In vitro experiments showed that down-regulation of circ_0091579 expression could remarkably inhibit the proliferative ability and metastasis of HCC cells. 31841181 hsa_circ_100395 CircRNA Homo sapiens Liver Neoplasms Liver Cancer tissues Interaction[miR-1228] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay We found that circ_100395 was Expression[down-expression]regulated in cancerous liver tissues relative to the adjacent normal tissues. The overexpression of circ_100395 was negatively associated with tumor differentiation, microvascular invasion, and portal vein tumor thrombosis. Moreover, Expression[Expression[up-expression]-expression]regulation of circ_100395 in liver cancer cells inhibited cell proliferation, induced apoptosis, then silenced the EMT pathway and reduced migration and invasion abilities, while this anti-tumor effect was significantly reversed by the Expression[down-expression]stream target, miR-1228. Yes The FACS showed that the numbers of apoptotic cells significantly increased after overexpression of circ_10039 in Huh7 and HepG2 cell lines (Figure 2F, 2G). The above experiments indicate that circ_10039 exerts an anti-growth effect in liver cancer cell lines. 31421050 hsa_circ_0000231 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC patients and cell lines CAL-27, Tca-8113 and HN-4 Regulation(Wnt/β-catenin signaling pathway) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay//Transwell Assay hsa_circ_0000231 was highly expressed in the tissue and saliva samples of TSCC patients and cell lines CAL-27, Tca-8113 and HN-4, but lowly expressed in paired para-carcinoma tissues, saliva samples of healthy people and normal human oral keratinocytes (all P<0.05). Log-rank univariate analysis showed that hsa_circ_0000231 expression level, tumor differentiation degree and T stage were related to the survival of TSCC patients (all P<0.05). Yes The knockdown of hsa_circ_0000231 reduced the proliferation, invasion and metastasis abilities of CAL-27 and Tca-8113 cells, which were reversed after TSCC cells were co-cultured with LiCl. The growth rate and volume of the tumors grafted subcutaneously in interference group using LiCl were greater than those in negative control group. 36319130 hsa_circ_0081069 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and cells Interaction( miR-634/MAP2K4 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//EdU Staining//Transwell Assay Circ_0081069 was highly expressed in TSCC tissues and cells. Mechanistically, circ_0081069 targeted miR-634 to negatively regulate miR-634 expression, and inhibition of miR-634 was able to weaken the inhibitory effect of circ_0081069 knockdown on proliferation, migration, and invasion of TSCC cells. MiR-634 targeted MAP2K4 and negatively regulated MAP2K4 expression, and overexpression of miR-634 inhibited TSCC cell proliferation, migration, and invasion, while co-overexpression of MAP2K4 was able to reverse the effects of miR-634 in TSCC cells. Yes Silencing of circ_0081069 inhibited cell proliferation, cell cycle progress, cell migration and invasion in vitro, as well as hindered tumor growth in vivo. 36181561 PITX1 LncRNA Homo sapiens Melanoma melanoma cells Regulation In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//ChIP Overexpression of PITX1 in melanoma cell lines resulted in a reduction in cell proliferation and an increase in apoptosis. Additionally, analysis of protein levels revealed an antagonistic cross-regulation between SOX9 and SOX10. Interestingly, PITX1 binds to the SOX9 promoter region as a positive regulatory transcription factor; PITX1 mRNA expression levels were positively correlated with SOX9 expression, and negatively correlated with SOX10 expression in melanoma tissues. Furthermore, transcription of the long noncoding RNA (lncRNA), survival-associated mitochondrial melanoma-specific oncogenic noncoding RNA (SAMMSON), was decreased in PITX1-overexpressing cells. Yes Overexpression of PITX1 in melanoma cell lines resulted in a reduction in cell proliferation and an increase in apoptosis. 34526609 PITPNA-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(microRNA-32-5p) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results demonstrated that PITPNA-AS1 was highly expressed in NSCLC tissues and cell lines. The luciferase reporter assay confirmed that miR-32-5p was a direct target of PITPNA-AS1. The rescue experiments suggested that a miR-32-5p inhibitor significantly reversed the inhibitory effects of PITPNA-AS1 silencing on proliferation, invasion, migration and EMT in NSCLC cells. Yes It was found that PITPNA-AS1 silencing inhibited the proliferation, invasion and migration of NSCLC cells. Furthermore, the protein expression of E-cadherin was upregulated, while the expression levels N-cadherin and vimentin were downregulated. 33495838 PIP5K1A CircRNA Homo sapiens Glioma glioma tissues Interaction(miR-515-5p/TCF12/PI3K/AKT pathway) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//RIP//IF//PCR//BrdU//IP//Transwell Assay The results manifested that CircPIP5K1A was upregulated in glioma tissues (compared with that in normal adjacent tissues), and overexpressed CircPIP5K1A was related to glioma volume and histopathological grade. Besides, CircPIP5K1A upregulated TCF12 and PI3K/AKT activation. Bioinformatics analysis testified that miR-515-5p was a common target of CircPIP5K1A and TCF12, while the dual-luciferase reporter assay and RNA immunoprecipitation (RIP) experiment further confirmed that CircPIP5K1A targeted miR-515-5p, which bound the 3'-untranslated region (UTR) of TCF12. Yes Functionally, overexpressing CircPIP5K1A notably elevated glioma cell proliferation, invasion, and EMT and inhibited apoptosis both in vivo and in vitro. 33413401 PITPNA-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-129-5p/ HMGB1 Axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining PITPNA-AS1 and HMGB1 mRNA expressions were observably elevated in CRC tissues and cell lines. PITPNA-AS1 can expedite CRC cell proliferation and migration, and inhibit apoptosis through miR-129-5p/HMGB1 axis. Yes Knocking down PITPNA-AS1 could significantly inhibit cell proliferation and migration, and promote apoptosis of CRC cells. 33312000 PITPNA-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[PITPNA-AS1/miR-876-5p/WNT5A axis] RNA Pull-Down//Northern Blot//Western Blot//Wound Healing Assay//Tunel//CCK8//qRT-PCR//FISH//IF//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Firstly, PITPNA-AS1 was observed to be heightened in HCC tissues.Moreover, mechanism experiments validated that PITPNA-AS1 modulated WNT5A expression by targeting miR-876-5p. Rescue experiments affirmed that WNT5A silencing rescued the miR-876-5p suppression-induced cellular processes in PITPNA-AS1-silenced Hep3B cells. And in vivo experiments determined that PITPNA-AS1 regulated HCC progression in vivo via miR-876-5p/WNT5A pathway. Yes Then function assays proved that overexpressing or silencing PITPNA-AS1 could manipulate the proliferation and motility of HCC cells. 31700026 PITPNA-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines regulation[miR-876-5p/c-MET axis] qRT-PCR In the study, we found that PITPNA-AS1 was markedly increased in human cervical cancer tissues and cell lines. PITPNA-AS1 meditated the effects of c-MET on the proliferation, apoptosis and cell cycle in cervical cancer cells by adsorbing miR-876-5p. Yes PITPNA-AS1 over-expression elevated the proliferation of cervical cancer cells, whereas PITPNA-AS1 knockdown reduced the cell proliferation. 32460193 PITPNA-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Interaction(miR-520d-5p and DDX54) In Vivo Experiment//RNA Pull-Down//IHC//ChIP//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//FISH//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay PITPNA-AS1 showed high expression levels in TNBC tissues and cells. Mechanistically, PITPNA-AS1 upregulated SIK2 expression by sponging miR-520d-5p and recruiting DDX54 protein. Results of rescue assays suggested that the inhibitive effects of silenced PITPNA-AS1 on TNBC cellular processes were partially rescued by overexpressing SIK2 or combination of miR-520d-5p inhibition and DDX54 overexpression. More importantly, we found that the upregulation of PITPNA-AS1 in TNBC cells was attributed to transcription factor MYBL2. Yes PITPNA-AS1 knockdown suppressed TNBC cell viability, proliferation, migration, invasion in vitro and inhibited xenograft tumor growth in mice. 34353336 PITPNA-AS1 LncRNA Homo sapiens Glioblastoma glioblastoma tissues Interaction(miR-223-3p/EGFR axis/PI3K/AKT signaling pathway) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining Firstly, RT-qPCR examined that PITPNA-AS1 was highly expressed in glioblastoma. After confirming that PITPNA-AS1 mainly existed in cell cytoplasm, we conducted mechanism assays which disclosed that PITPNA-AS1 sequestered microRNA-223-3p (miR-223-3p) and modulated epidermal growth factor receptor (EGFR) expression, thereby participating in the activation of PI3K/AKT signaling pathway. Yes The results demonstrated that depletion of PITPNA-AS1 inhibited the proliferation and promoted the apoptosis of glioblastoma cells. 34470587 PITPNA-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary papillary thyroid cancer tissues and cell lines Interaction( miR-129-5p/UNC5B axis) Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//EdU Staining PITPNA-AS1 and UNC5B expressions were markedly increased in papillary thyroid cancer tissues and cell lines while miR-129-5p expression was down-regulated. PITPNA-AS1 targeted miR-129-5p to repress its expression and miR-129-5p targeted UNC5B to repress its expression. Silencing PITPNA-AS1 reduced the expression of UNC5B via regulating miR-129-5p expression. Yes Knockdown of PITPNA-AS1 could significantly inhibit papillary thyroid cancer cell growth and migration and promote cell apoptosis while UNC5B overexpression plasmids or miR-129-5p inhibitors counteracted the knockdown effect of PITPNA-AS1 on papillary thyroid cancer cells. 33706585 PITPNA-AS1 LncRNA Homo sapiens lung squamous cell carcinoma LUSC samples,LUSC cells regulation[stabilizing HMGB3 by TAF15] RNA Pull-Down//Western Blot//Tunel//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Through online database GEPIA, lncRNA PITPNA antisense RNA 1 (PITPNA-AS1) was highly expressed in LUSC samples, and these tendency was further affirmed in LUSC cells. All in all, PITPNA-AS1 promoted the proliferation and migration of LUSC cells via stabilizing HMGB3 by TAF15. Yes Functional experiments verified that depletion of PITPNA-AS1 hampered the proliferative and migratory abilities, but accelerated apoptosis of LUSC cells. 32871048 PITPNA-AS1 LncRNA Homo sapiens lung squamous cell carcinoma LUSC tissues and cells Interaction(LncRNA PITPNA-AS1/miR-223-3p/PTN axis ) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay// In Vivo Experiment//Colony Formation Assay//Transwell Assay The lncRNA PITPNA-AS1 had increased expression in LUSC and was linked to a poor prognosis. This mechanistic investigation showed that PITPNA-AS1 absorbed miR-223-3p and that miR-223-3p targeted PTN. MiR-223-3p inhibition or PTN overexpression might reverse the inhibitory effects of PITPNA-AS1 suppression on LUSC progression, as demonstrated by rescue experiments. In addition, the PITPNA-AS1/miR-223-3p/PTN axis accelerated tumor development in vivo. The lncRNA PITPNA-AS1 had increased expression in LUSC and was linked to a poor prognosis. Yes In LUSC, PITPNA-AS1 also enhanced cell proliferation, migration, invasion, and stemness. 35588441 PCAT6 LncRNA Homo sapiens Pituitary Neoplasms PA tissues Interaction(miR-139-3p/BRD4 axis) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//Tunel//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay PCAT6 and BRD4 were high-expressed but miR-139-3p was low-expressed in PA. Both the 3'-untranslated regions of PCAT6 and BRD4 mRNAs were demonstrated to contain a potential binding site for miR-139-3p. PCAT6 was positively correlated to BRD4, and miR-139-3p was negatively correlated to PCAT6 and BRD4. Yes MiR-139-3p mimic, shPCAT6 and siBRD4 inhibited the viability, migration, invasion, and proliferation of PA cells while inducing apoptosis. MiR-139-3p mimic and shPCAT6 inhibited the cell cycle progression of PA cells, decreased the weight and volume of the xenotransplanted tumor, and reduced the levels of Bcl-2 and BRD4 while enhancing the levels of Bax, miR-139-3p, and Cleaved caspase-3. 33407504 PCAT29 LncRNA Homo sapiens Neuroblastoma NB tissues and cells Interaction(miR-21 ) qRT-PCR The results showed that PCAT29 was downregulated and miR-21 was upregulated in NB. MiR-21 was inversely correlated with PCAT29. RNA-RNA interaction prediction revealed that miR-21 might target PCAT29.MiR-21 overexpression reduced PCAT29 expression and increased NB cell proliferation, whereas PCAT29 overexpression inhibited NB cell proliferation. PCAT29 overexpression promoted NB cell apoptosis, while miR-21 overexpression inhibited NB cell apoptosis and attenuated PCAT29 overexpression-mediated NB cell apoptosis. Yes MiR-21 overexpression reduced PCAT29 expression and increased NB cell proliferation, whereas PCAT29 overexpression inhibited NB cell proliferation. PCAT29 overexpression promoted NB cell apoptosis, while miR-21 overexpression inhibited NB cell apoptosis and attenuated PCAT29 overexpression-mediated NB cell apoptosis. 36017911 circFLNA CircRNA Homo sapiens bladder carcinoma BCa tissues and cell lines Interaction(miR-216a-3p/BTG2 axis) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Our study confirmed that downregulated circFLNA and BTG2 expression and upregulated miR-216a-3p were found in both BCa tissues and cell lines. MiR-216a-3p was a target gene of circFLNA and could target BTG2. Further analysis finally demonstrated that circFLNA sponged miR-216a-3p and indirectly promoted BTG2 expression, ultimately regulating proliferation, migration, invasion and EMT of BCa cells. Yes Meanwhile, upregulated circFLNA inhibited proliferation, invasion and migration, EMT and stemness of BCa cells. 34852712 OXP4-AS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-3184-5p/EIF5A axis) qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Western Blot The results showed that FOXP4-AS1 was upregulated and miR-3184-5p was downregulated in NSCLC tissues and cell lines. FOXP4-AS1 could regulated the expression of EIF5A by binding to miR-3184-5p. Rescue experiments showed that downregulation of miR-3184-5p or overexpression of EIF5A obviously attenuated the inhibitory effects of si-FOXP4-AS1 on cell proliferation, as well as the stimulating effects on cell apoptosis. Yes Downregulation of FOXP4-AS1 significantly reduced cell proliferation and induced apoptosis of NSCLC cells in vitro. Moreover, knockdown of FOXP4-AS1 could efficiently inhibited tumor development of NSCLC in vivo. 34921595 circFOXM1 CircRNA Homo sapiens Melanoma melanoma tissues and cells regulation[miR-143-3p/FLOT2 axis] Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay Circ-FOXM1 was elevated and miR-143-3p was reduced in melanoma tissues and cells. Circ-FOXM1 facilitated the development of melanoma by upregulating FLOT2 through miR-143-3p. Yes Circ-FOXM1 deficiency impeded cell proliferation, invasion, and glycolysis and facilitated cell apoptosis in melanoma in vitro and tumorigenesis in vivo. 32183822 hsa_circ_0002770 CircRNA Homo sapiens Melanoma Melanoma tissues interaction[targeting miR-331-3p] RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, we identified a circular RNA, circ_0002770, which is produced from the well-known oncogene MDM2, and was sharply increased in melanoma and correlated with a poor prognosis. Mechanistically, circ_0002770 acted as a sponge of miR-331-3p and could indirectly regulate DUSP5 and TGFBR1. Inhibition of miR-331-3p reversed the inhibitory effect of si-circ_0002770 on melanoma cell proliferation and invasion. Yes Knockdown of circ_0002770 suppressed melanoma cell invasion, migration and proliferation. 32327630 P5848 LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues Regulation[LncRNA P5848-ENO1 axis] Western Blot//qRT-PCR//FISH//MTT//Luciferase Report Assay We identified an LncRNA P5848, whose expression level was Expression[Expression[up-expression]-expression]-regulated in tumor samples from HCC patients after radiofrequency ablation.Mechanistically, we have found that ENO1 was the target of LncRNA P5848. LncRNA P5848 Expression[Expression[up-expression]-expression]-regulated the gene and protein expression level of ENO1, promoting tumor growth and cell survival. However, siRNA-mediated knockExpression[down-expression] of ENO1 counteracted the effects of LncRNA P5848 on cancer cell growth, cell survival, and migration. Taken together, LncRNA P5848 promotes HCC development by Expression[Expression[up-expression]-expression]-regulating ENO1, indicating that LncRNA P5848-ENO1 axis is a potential therapeutic target for the treatment of HCC. Yes As such, we speculated that LncRNA P5848 may play a role in tumor growth. Here we showed that LncRNA P5848, whose Expression[Expression[up-expression]-expression]-regulation can lead to HCC cancer cell proliferation and migration. In vitro and in vivo overexpression of LncRNA P5848 promoted cell growth, cell survival, and cell invasion, whereas LncRNA P5848 depletion exerts opposite effects. 30541900 hsa_circ_0020710 CircRNA Homo sapiens Melanoma melanoma tissues regulation[miR-370-3p/CXCL12 axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our findings indicated that circ_0020710 was generally overexpressed in melanoma tissues, and high level of circ_0020710 was positively correlated with malignant phenotype and poor prognosis of melanoma patients. Elevated circ_0020710 drives tumor progression via the miR-370-3p/CXCL12 axis, and circ_0020710 is a potential target for melanoma treatment. Our findings indicated that circ_0020710 was generally overexpressed in melanoma tissues, and high level of circ_0020710 was positively correlated with malignant phenotype and poor prognosis of melanoma patients. Yes Elevated circ_0020710 promoted melanoma cell proliferation, migration and invasion in vitro as well as tumor growth in vivo. 32381016 circHIPK3 CircRNA Homo sapiens Melanoma melanoma tissues and cell lines regulation[miR-215-5p/YY1 axis] qRT-PCR//Luciferase Report Assay//RIP//Western Blot CircHIPK3 expression was strikingly upregulated while miR-215-5p was downregulated in melanoma tissues and cell lines.Our study corroborated that circHIPK3 regulated melanoma cell behaviors via the miR-215-5p/YY1 axis, which might provide a novel insight for the treatment of melanoma patients. Yes Moreover, we confirmed that overexpression of circHIPK3 could facilitate cell proliferation and depress cell apoptosis in melanoma while overexpression of miR-215-5p exerted opposite effects. 32800940 p4516 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Expression[highly expressed] FISH//IHC//Western Blot//qRT-PCR LncRNA p4516 was mainly localized in the nucleus of GC cells and p4516 tended to have higher expression levels in GC cells compared to the normal gastric mucosa-derived cells GES-1. Yes Functional analysis revealed that p4516 participated in the regulation of GC cell proliferation, invasion and migration both in vivo and in vitro. 31354346 hsa_circ_0001591 CircRNA Homo sapiens Melanoma blood regulation[ROCK1/PI3K/AKT signal pathway,miR-431-5p] qRT-PCR//MTT The expression of circ 0001591 in serum of patients with melanoma was increased. Our findings demonstrated that circ 0001591 inhibits the progression of human melanoma through ROCK1/PI3K/AKT signal pathway by targeting ROCK1 by miR-431-5p. Yes Up-regulation of circ 0001591 promoted cell growth and cell invasion, and reduced apoptotic rate of melanoma. Down-regulation of circ 0001591 reduced cell growth and cell invasion, and promoted apoptotic rate of melanoma. 32830578 hsa_circ_0079593 CircRNA Homo sapiens Melanoma melanoma tumor tissues regulation[miR-516b/GRM3 axis] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our results discovered that circ_0079593 was highly expressed in melanoma,Our study concluded that circ_0079593 accelerated melanoma progression via upregulating GRM3 by sponging miR-516b, which suggested that circ_0079593 had the potential to be a new therapeutic biomarker for melanoma. Yes Our results discovered that circ_0079593 was highly expressed in melanoma, and its silencing suppressed melanoma cell proliferation, migration, invasion, glucose metabolism and promoted apoptosis. 32839935 OXCT1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-195/CCNE1 axis) qRT-PCR//Colony Formation Assay//Luciferase Report Assay//Western Blot LncRNA OXCT1-AS1 was highly expressed and miR-195 was lowly expressed in NSCLC tissues and cell lines. LncBase predicted v.2.0 reported a high-scoring binding between OXCT1-AS1 and miR-195. The luciferase reporter assay defined the regulatory relationship between OXTC1-AS1 and miR-195.Furthermore, according to the results of the dual-luciferase activity assay, miR-195 targeted the 3' untranslated regions (3' UTRs) of CCNE1, validating that CCNE1 is a direct target of miR-195. Overexpression of CCNE1 restored the role of OXCR1-AS1 in NSCLC cells. Yes In NSCLC cells, knockdown of OXCT1-AS1 significantly increased the expression of miR-195, decreased the proliferation and colony formation number of cancer cells, and reduced the expression of CCND1 and CCNE1. Meanwhile, overexpression of miR-195 significantly inhibited the cell proliferation and colony formation number, and reduced the expression of CCND1 and CCNE1. 35706791 PACERR LncRNA Homo sapiens pancreatic ductal adenocarcinoma TAMs Interaction(miR-671-3p/KLF12/p-AKT/c-myc pathway) In Vivo Experiment//qRT-PCR//Luciferase Report Assay//Western Blot LncRNA-PACERR was high expression in TAMs and associated with poor prognosis in PDAC patients.Mechanistically, LncRNA-PACERR activate KLF12/p-AKT/c-myc pathway by binding to miR-671-3p. And LncRNA-PACERR which bound to IGF2BP2 acts as an m6A-dependent manner to enhance the stability of KLF12 and c-myc in cytoplasm. In addition, the promoter of LncRNA-PACERR was a target of KLF12 and LncRNA-PACERR recruited EP300 to increase the acetylation of histone by interacting with KLF12 in nucleus. Yes Our finding validated that LncRNA-PACERR increased the number of M2-polarized cells and facilized cell proliferation, invasion and migration in vitro and in vivo. 35526050 OXCT1-AS1 LncRNA Homo sapiens Osteosarcoma OS cells Interaction(miR-886) qRT-PCR//RNA Pull-Down The expression of OXCT1-AS1 and miR-886 (mature and premature) in osteosarcoma and paired non-tumor tissues from 66 OS patients was negatively correlated. Overexpression and silencing assays showed that OXCT1-AS1 suppresses miR-886 maturation. RNA-RNA pulldown and subcellular fractionation assays demonstrated the direct interaction between OXCT1-AS1 and miR-886. Yes BrdU proliferation assays revealed that OXCT1-AS1 promoted OS cell proliferation, and miR-886 reduced the enhancing effects of OXCT1-AS1 on OS cell proliferation. 35191809 OXCT1-AS1 LncRNA Homo sapiens Glioblastoma GBM tissue samples Interaction(miR-195/CDC25A axis) IHC//Western Blot//Transwell Assay//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//IF In this study, it was found that the expression of lncRNA OXCT1-AS1 was upregulated in both The Cancer Genome Atlas (TCGA) GBM patients and GBM tissue samples, and high expression of OXCT1-AS1 predicted a poor prognosis. We further investigated the potential mechanism and found that OXCT1-AS1 may act as a ceRNA of miR-195 to enhance CDC25A expression and promote glioma cell progression. In this study, it was found that the expression of lncRNA OXCT1-AS1 was upregulated in both The Cancer Genome Atlas (TCGA) GBM patients and GBM tissue samples, and high expression of OXCT1-AS1 predicted a poor prognosis. Yes Suppressing OXCT1-AS1 expression significantly decreased GBM cell proliferation and inhibited cell migration and invasion.Finally, knocking down OXCT1-AS1 notably attenuated the severity of glioma in vivo. 33832517 OXCT1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell lines Regulation(LEF1) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Cell Proliferation Assay//Transwell Assay Results indicated that lncRNA OXCT1-AS1 expression was significantly increased in NSCLC cell lines. Mechanistically, through direct interaction, lncRNA OXCT1-AS1 maintained LEF1 stability by blocking NARF-mediated ubiquitination. Furthermore, LEF1 knockdown impaired invasion and migration of NSCLC in vitro and in vivo. Yes Functional analysis revealed that knockdown of lncRNA OXCT1-AS1 impaired invasion and migration in vitro.Additionally, the ability of lncRNA OXCT1-AS1 to promote NSCLC metastasis was also confirmed in vivo. 34337014 circRNF20 CircRNA Homo sapiens Retinoblastoma RB tissues and cells Interaction(miR-132-3p/PAX6 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay It was found that ircRNF20 level was increased in RB tissues and linked to advanced tumor, nodes, metastases (TNM) stage and poor overall survival rate. circRNF20 directly targeted miR-132-3p and miR-132-3p overexpression inhibited RB cell progression. PAX6 was the target gene of miR-132-3p. Moreover, miR-132-3p inhibition or PAX6 overexpression reversed circRNF20 deficiency-mediated effects on RB cell malignant behaviors. In addition, exosomal circRNF20 was able to promote RB cell progression. It was found that ircRNF20 level was increased in RB tissues and linked to advanced tumor, nodes, metastases (TNM) stage and poor overall survival rate. Yes Deficiency of circRNF20 suppressed cell proliferation, migration and invasion and induced apoptosis in vitro, as well as blocked tumor growth in vivo. 35663593 OXCT1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-516b-5p/SLC1A5) Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay Circ-OXCT1 and SLC1A5 were upregulated and miR-516b-5p was downregulated in NSCLC tissues and cells. Besides, miR-516b-5p was a target of circ-OXCT1, and miR-516b-5p inhibitor could relieve circ-OXCT1 absence-mediated effects in NSCLC cells. SLC1A5 was identified as a target of miR-516b-5p. Circ-OXCT1 promoted SLC1A5 expression by target binding with miR-516b-5p.Circ-OXCT1 facilitated NSCLC progression via miR-516b-5p-dependent regulation of SLC1A5, which provided a possible circRNA-targeted therapy for NSCLC. Yes Functional experiments revealed that circ-OXCT1 silencing suppressed cell proliferation, migration and invasion, but promoted cell apoptosis in vitro. Circ-OXCT1 knockdown repressed tumor formation in vivo. 35482822 circCUL2 CircRNA Homo sapiens Retinoblastoma retinoblastoma tumor tissues and cells Interaction(miR-214-5p/E2F2 Axis) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay CircCUL2 and E2F2 were lowly expressed, while miR-214-5p was highly expressed in retinoblastoma tumor tissues and cells. CircCUL2 negatively regulated miR-214-5p, while miR-214-5p negatively regulated E2F2. Overexpression of miR-214-5p or silencing of E2F2 in SO-Rb50 cells partially reversed the inhibitory effect of circCUL2 on the proliferation, invasion and migration of retinoblastoma cells. CircCUL2 inhibited the proliferation, invasion and migration of retinoblastoma cells by regulating the miR-214-5p/E2F2 axis. Yes Transfection with pcDNA3.1-CUL2 or miR-214-5p inhibitor inhibited the proliferation, invasion and migration of Y79 and SO-Rb50 cells compared with the negative control; while transfection with sh-CUL2 or miR-214-5p mimics promoted the proliferation, invasion and migration of Y79 and SO-Rb50 cells. 34387590 OTUD6B-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC cells and tissues Interaction(microRNA-3171) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results demonstrated that OTUD6B-AS1 expression was low in CRC cells and tissues.Furthermore, miR-3171 was demonstrated to be a direct target of OTUD6B-AS1 using a luciferase reporter assay. The rescue assays revealed that miR-3171 mimics markedly reversed the inhibitory effects of OTUD6B-AS1 overexpression on proliferation, invasion and migration of CRC cells. Yes Overexpression of OTUD6B-AS1 inhibited the proliferation, invasion and migration of HCT116 cells. 33574932 OTUD6B-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[GSKIP/Wnt/β-catenin signalling] qRT-PCR//Colony Formation Assay We found that the expression of OTUD6B-AS1 was up-regulated in HCC tissues, and patients with high levels of OTUD6B-AS1 expression had shorter survival rates than those with low OTUD6B-AS1 expression. Overall, these findings indicate that the lncRNA OTUD6B-AS1 accelerates the proliferation and invasion of HCC cells by enhancing GSKIP/Wnt/β-catenin signalling via the sequestration of miR-664b-3p. We found that the expression of OTUD6B-AS1 was up-regulated in HCC tissues, and patients with high levels of OTUD6B-AS1 expression had shorter survival rates than those with low OTUD6B-AS1 expression. Yes Elevated expression of the lncRNA was also found in multiple HCC cell lines and the silencing of OTUD6B-AS1 significantly decreased proliferation, colony formation and invasion. 32682012 hsa_circ_0084043 CircRNA Homo sapiens Melanoma melanoma tissues and cell lines regulation[miR429/TRIB2 axis,Wnt/β-catenin signaling pathway] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay Expression of circ_0084043 and TRIB2 was upregulated in human melanoma tissues and cell lines. Knockdown of circ_0084043 suppressed the malignant development of melanoma presumably through modulating miR429/TRIB2 axis and inactivating Wnt/β-catenin signaling pathway. Yes Both circ_0084043 knockdown and TRIB2 silencing could decrease cell proliferation, migration and invasion, but facilitate apoptosis in A375 and SK-MEL-28 cells. 31954160 PAGR1 LncRNA Homo sapiens Glioma cell lines Expression[lower expressed] CCK8//qRT-PCR//Transwell Assay//Western Blot The expression of lncRNA GAS5 was significantly decreased in glioma cell lines U251 and U87 compared with normal glial cells HEB (p < 0.01). Yes n addition, overexpression of lncRNA GAS5 inhibited the proliferation, migration and invasion of U251 and U87 cells, and promoted cell apoptosis as demonstrated by the increased activity of Caspase 3/7. 31172354 OTUD6B-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissue Regulation[Wnt/β-catenin signaling pathway] IHC//Western Blot//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//IF In this study, we found that the expression of the lncRNA OTUD6B-AS1 was downregulated in ccRCC tissue samples.The overexpression of OTUD6B-AS1 decreased the activity of the Wnt/β-catenin pathway and suppressed the expression of epithelial-to-mesenchymal transition (EMT)-related proteins (E-cadherin, N-cadherin and Snail) in ccRCC cells. In this study, we found that the expression of the lncRNA OTUD6B-AS1 was downregulated in ccRCC tissue samples and that patients with low OTUD6B-AS1 expression had shorter overall survival than patients with high OTUD6B-AS1 expression, which showed that the different expression level of OTUD6B-AS1 indirectly correlated with survival of patients. Yes Furthermore, OTUD6B-AS1 overexpression partly inhibited cell migration and invasion.In addition, compared with the parental ACHN cells, OTUD6B-AS1-overexpressing ACHN cells injected into nude mice exhibited decreased tumor growth in vivo. 30670025 PANDAR LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation(CDK4) qRT-PCR Here, we report that expression of PANDAR is significantly up-regulated in glioma tissues and cell lines. Furthermore, PANDAR knockdown suppressed cell proliferation, G1/S transition, migration and invasion, and promoted apoptosis in glioma cell lines (U251 and U87). PANDAR knockdown decreased expression of CDK4, Bcl-2, N-cadherin and Vimentin, but increased E-cadherin expression in glioma cells. PANDAR expression was correlated with tumor size (p=0.044) and World Health Organization (WHO) grades (p=0.005), as shown by chi-squared test. Moreover, significant upregulation of PANDAR was found to correlate with poor prognosis in glioma, as shown using Kaplan-Meier method and Cox multivariate survival analysis. Yes Furthermore, PANDAR knockdown suppressed cell proliferation, G1/S transition, migration and invasion, and promoted apoptosis in glioma cell lines (U251 and U87). PANDAR knockdown decreased expression of CDK4, Bcl-2, N-cadherin and Vimentin, but increased E-cadherin expression in glioma cells. 36073766 PAQR7 CircRNA Homo sapiens Osteoarthritis OA tissues and cells Interaction(miR-761/FBXO21 ) IP//Transfection//Western Blot//IF circRNA-MSR and FBXO21 levels were elevated in OA, but miR-761 level was inhibited. Suppressing circRNA-MSR promoted the autophagy of LPS-treated cells. circRNA-MSR could bind to miR-761 and inhibit its expression. MiR-761 inhibition reversed the promoted autophagy caused by circRNA-MSR knockdown in LPS-treated C28/I2 cells. Moreover, miR-761 could target FBXO21 and inhibit its expression. FBXO21 overexpression reversed the increased autophagy caused by miR-761 overexpression in LPS-treated C28/I2 cells. Yes Suppressing circRNA-MSR promoted the autophagy of LPS-treated cells. 36278814 hsa_circ_0001776 CircRNA Homo sapiens Endometrial Neoplasms EC tissues and cells regulation[miR-182/LRIG2 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay Circ_0001776 and LRIG2 were downregulated, while miR-182 was upregulated in EC tissues and cells. Our results confirmed that circ_0001776 inhibited EC tumorigenesis and progression via miR-182/LRIG2 axis, providing a potential therapeutic target for EC. Low expression of circ_0001776 was correlated with the 5-year survival rate of EC patients. Yes Upregulated circ_0001776 markedly attenuated cell proliferation and glycolysis, and enhanced cell apoptosis. 32863771 PAPPA-AS1 LncRNA Homo sapiens Cicatrix, Hypertrophic HTS tissues and hypertrophic scar fibroblast (HTsFb) cells Interaction(TAF15/TLR4 ) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Transfection//qRT-PCR//FISH//RIP//Luciferase Report Assay//H&E Staining//Cell Proliferation Assay//IF PAPPA-AS1 was significantly upregulated in both HTS tissues and hypertrophic scar fibroblast (HTsFb) cells.Positive correlation and interaction were observed between PAPPA-AS1 and TAF15 and between TAF15 and the promoter of TLR4, respectively. In conclusion, lncRNA PAPPA-AS1 might induce the development of HTS by upregulating TLR4 through interacting with TAF15. Yes By knocking down PAPPA-AS1, the proliferation of HTsFb cells, TLR4, and TGF-β1 signal pathway and the expression of fibrosis markers both in HTsFb cells and HTS tissues were suppressed. It was accompanied by the alleviated pathological state in the HTS tissues, which were significantly reversed by cotransfecting with the pcDNA3.1-TLR4 vector. 34285657 PANTR1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues and HCC cell lines Interaction(miR-587/BCL2A1 axis) CCK8//qRT-PCR//RNA Pull-Down//FISH Our study found that lncRNA PANTR1 was upregulated in HCC tumor tissues and abundantly expressed in HCC cell lines. PANTR1 acted as a competent sponge for miR-587 and downregulated miR-587 expression in HCC cells. Further, MiR-587 directly targets BCL2A1. lncRNA PANTR1 promotes HCC progression via mediating the miR-587-BCL2A1 axis. Yes PANTR1 knockdown inhibited cell growth and migration, promoted cell apoptosis in vitro, and suppressed tumor cell growth in vivo. Moreover, our results suggest that downregulated PANTR1 inhibited the Warburg effect in HCC cells. 34423048 PANDAR LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[EMT pathway] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay We demonstrated that lncRNA PANDAR expression was higher in breast cancer tissues and cells compared with adjacent normal tissues and the normal mammary epithelial cell line, respectively.Furthermore, we verified that knockExpression[down-expression] of lncRNA PANDAR dramatically inhibited cell epithelial-mesenchymal transition (EMT) pathway by Expression[down-expression]regulating Vimentin, MMP2 and MMP9 expression, but Expression[Expression[up-expression]-expression]regulating E-cadherin expression in breast cancer. Higher lncRNA PANDAR expression positively associated with lymph node metastasis and advanced clinical stage in patients. Yes In vitro, we demonstrated that knockExpression[down-expression] of lncRNA PANDAR significantly sExpression[Expression[up-expression]-expression]pressed cell proliferation, cell colony formation and cell invasion ability in breast cells. 31104011 PANDAR LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell lines Expression[lower expressed] CCK8//qRT-PCR//Western Blot PANDAR was found to downregulate both in lung cancer tissues and cell lines compared with corresponding controls (P < 0.05 for all), which was related to tumor stage (P < 0.05). Yes So, the high expression of PANDAR increased BECN1 expression levels and impaired the proliferation of NSCLC cell lines in vitro. 32626525 PANDAR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells Interaction(SRSF7/PIM1) CCK8//qRT-PCR//RNA Pull-Down//Western Blot First of all, PANDAR was highly expressed in OSCC cells and loss-of-function assays mediated by CRISPR-dCas9 observed that PANDAR silencing restrained cell proliferation and promoted cell apoptosis. Subsequently, serine/threonine-protein kinase pim-1 (PIM1) was proved to be regulated by PANDAR in SRSF7-dependant way. Rescue experiments validated that PANDAR modulated the proliferation and apoptosis in OSCC through PIM1. Yes First of all, PANDAR was highly expressed in OSCC cells and loss-of-function assays mediated by CRISPR-dCas9 observed that PANDAR silencing restrained cell proliferation and promoted cell apoptosis. 33842552 PANDAR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Expression(highly expressed) qRT-PCR//Invasion Assay//Migration Assay PANDAR was highly expressed in OSCC tissues and cell lines (P < 0.05) and its high expression level was found to be closely associated with advanced TNM stage (P = 0.004) and positive distant metastasis (P = 0.001). PANDAR was highly expressed in OSCC tissues and cell lines (P < 0.05) and its high expression level was found to be closely associated with advanced TNM stage (P = 0.004) and positive distant metastasis (P = 0.001). Furthermore, overall survival rate of OSCC patients with high PANDAR expression was poorer than patients with low PANDAR expression (P < 0.001). Cox proportional hazards model analysis showed that expression level of PANDAR can be used as an independent prognostic indicator for OSCC. Yes Functionally, knockdown of PANDAR can inhibit proliferation, invasion, and migration of OSCC cells. 31938389 hsa_circ_0103232 CircRNA Homo sapiens Melanoma melanoma patients and cells Interaction( miR-661/RAB3D) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//CCK8//FISH//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay Hsa_circ_0103232 expression was increased in melanoma patients, indicating lower overall survival. Hsa_circ_0103232 functioned as a sponge of miR-661 to increase RAB3D expression. miR-661 overexpression partially reversed hsa_circ_0103232 promoting effect on melanoma cells viability, proliferation, migration, invasion, and EMT (P < 0.01). In melanoma patients, hsa_circ_0103232 expression was negatively correlated with miR-661 and positively correlated with RAB3D. Hsa_circ_0103232 expression was increased in melanoma patients, indicating lower overall survival. Yes Hsa_circ_0103232 was mainly expressed in the cytoplasm of melanoma cells. Silencing hsa_circ_0103232 suppressed melanoma cell viability, proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) (P < 0.01). Silencing hsa_circ_0103232 suppressed melanoma cell growth in vivo and Ki67 and RAB3D expression in xenograft tumors (P < 0.01). 35549813 PAICC LncRNA Homo sapiens Cholangiocarcinoma human ICC tissues Interaction( miR-141-3p and miR-27a-3p) Bioinformatics Analysis In the present work, we used bioinformatics analysis to identify the differentially expressed lncRNAs in human ICC tissues, among which lncRNA-PAICC was found to be an independent prognostic marker in ICC. Mechanistically, lncRNA-PAICC acted as a competitive endogenous RNA (ceRNA) that directly sponged the tumor suppressive microRNAs miR-141-3p and miR-27a-3p. The competitive binding property was essential for lncRNA-PAICC to promote tumor growth and metastasis through activating the Hippo pathway. Yes Moreover, lncRNA-PAICC promoted the proliferation and invasion of ICC cells. 33552968 circITCH CircRNA Homo sapiens Melanoma melanoma tissues and cells Interaction(miR-660/TFCP2 pathway) In Vivo Experiment//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Results revealed that circITCH expression was repressed in melanoma versus adjacent normal tissues. The mechanism study showed that circITCH-sponged miR-660 to upregulate TFCP2 and suppress melanoma progression. Yes Function study showed that circITCH suppressed melanoma cell proliferation and metastasis. 35274492 PANDAR LncRNA Homo sapiens Thyroid Neoplasms thyroid gland carcinoma cells Interaction(miR-637/KLK4) In Vivo Experiment//Western Blot//Luciferase Report Assay//Transwell Assay We identified Promoter Region of CDKN 1A antisense DNA damage-activated RNA (PANDAR), which was positively correlated with thyroid gland carcinoma risk.PANDAR negatively correlated with miR-637, and miR-637 overexpression suppressed thyroid gland carcinoma progression, which could be reversed by PANDAR. MiR-637 could target Kallikrein-related peptidases 4 (KLK4) to inhibit its expression, which was high in thyroid gland carcinoma. Yes PANDAR could promote thyroid gland carcinoma cell proliferation and metastasis. 34476001 hsa_circ_0079593 CircRNA Homo sapiens Melanoma melanoma tissue samples and cell lines (microRNA-433 & EGFR) CCK8//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay It was found that, in comparison with the normal control group, circ-0079593 showed a significantly high expression in melanoma tissues and cell lines, which predicted a poor prognosis of melanoma patients. In vitro experiments showed that the overexpression of circ-0079593 remarkably enhanced proliferation rate, as well as invasion ability of melanoma cells. Moreover, bioinformatics data analysis revealed that there exist binding sites of microRNA-433 both in circ-0079593 and EGFR. Meanwhile, the results of the Luciferase assay confirmed that circ-0079593 probably bound to microRNA-433, as an endogenous competitive RNA (ceRNA), to regulate EGFR expression. At last, cell reverse experiments demonstrated that the overexpression of microRNA-433 could attenuate the capacity of melanoma cells to proliferate and migrate, while simultaneous overexpression of circ-0079593 partially restored those cell functions. It was found that, in comparison with the normal control group, circ-0079593 showed a significantly high expression in melanoma tissues and cell lines, which predicted a poor prognosis of melanoma patients. Yes In vitro experiments showed that the overexpression of circ-0079593 remarkably enhanced proliferation rate, as well as invasion ability of melanoma cells. 33577032 PANDAR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues,cell lines Regulation[ CyclinD1/2-Cyclin E1 and Bcl-2 pathways] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Colony Formation Assay//EdU Staining Quantitative real-time PCR (qRT-PCR) was carried out to detect the PANDA expression, which was up-regulated in matched cancerous tissues and adjacent noncancerous tissues from 134 patients and 9 ESCC cell lines.In addition, PANDA binds SAFA to switch on the tumor proliferation program through CyclinD1/2-Cyclin E1 and Bcl-2 pathways. Higher expression of PANDA in ESCC tissues was associated with TNM stage, advanced clinical stage, and shorter overall survival of ESCC patients by MTT, EDU, colony formation assay and flow cytometry in KYSE180 and KYSE450 cells. Yes Exogenous down-regulation of PANDA expression significantly suppressed ESCC cells proliferation and colony formation by arresting G1-S checkpoint transition in vitro, and retarded the development of tumors in vivo. 31495606 hsa_circ_0062270 CircRNA Homo sapiens Melanoma melanoma tissues and cells Interaction(miR-331-3p) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay The expression of circ_0062270 was increased in melanoma tissues and cells. Yes Knockdown of circ_0062270 inhibited proliferation, promoted apoptosis, and repressed metastasis in melanoma. Moreover, circ_0062270 could serve as miR-331-3p sponge, and miR-331-3p could target EPHA2. 34454812 PAINT LncRNA Rattus norvegicus Prostatic Neoplasms cell lines Expression(highly expressed) In Vivo Experiment//qRT-PCR//Western Blot Inhibition of PAINT decreased cell proliferation, S-phase progression, increased expression of apoptotic markers, and improved sensitivity to docetaxel and Aurora kinase inhibitor VX-680. Inhibition of PAINT decreased cell migration and reduced expression of Slug and Vimentin. Upregulation of PAINT was noted in advanced stage and metastatic PCa. Upregulation of PAINT was noted in advanced stage and metastatic PCa. Yes Inhibition of PAINT decreased cell proliferation, S-phase progression, increased expression of apoptotic markers, and improved sensitivity to docetaxel and Aurora kinase inhibitor VX-680. Inhibition of PAINT decreased cell migration and reduced expression of Slug and Vimentin. Ectopic expression of PAINT suppressed E-cadherin, increased S-phase progression and cell migration. 33729568 OTUD6B-AS1 LncRNA Homo sapiens Thyroid Neoplasms thyroid carcinoma tissue interaction[miR-183-5p and miR-21] qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay OTUD6B-AS1 was downregulated in thyroid carcinoma tissue samples. Taken together, our findings present in vitro evidence of lncRNA OTUD6B-AS1 as a tumor suppressor in thyroid carcinomas. OTUD6B-AS1 inhibits viability, migration, and invasion of thyroid carcinoma by targeting miR-183-5p and miR-21. The expression of OTUD6B-AS1 correlated with tumor size, clinical stage, and lymphatic metastasis of thyroid carcinoma. Yes Overexpression of OTUD6B-AS1 significantly decreased the viability, migration, and invasion of thyroid carcinoma cells. 32256450 hsa_circ_0075804 CircRNA Homo sapiens Retinoblastoma RB tissues and cells Interaction(MiR-1287-5p/LASP1) In Vivo Experiment//IHC//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Upregulation of circ_0075804 and LASP1, and downregulation of miR-1287-5p were shown in RB tissues and cells.MiR-1287-5p was targeted by circ_0075804, and its repression largely reversed the functional effects of circ_0075804 knockdown. LASP1 was a functional target of miR-1287-5p. The inhibition of miR-1287-5p upregulation on RB cell proliferation, survival and invasion was reversed by LASP1 overexpression. Moreover, circ_0075804 knockdown weakened LASP1 expression via increasing miR-1287-5p. Yes Circ_0075804 knockdown repressed RB cell growth, invasion and survival, and hindered tumor development in vivo. 35285372 circPUM1 CircRNA Homo sapiens Endometrial Neoplasms endometrial tissue regulation[miR-136/NOTCH3 pathway] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay//Invasion Assay Circ_PUM1 was expressed at significantly higher levels in endometrial cancer tissues than in normal tissues.Circ_PUM1 can compete with miR-136, leading to up-regulation of NOTCH3, and thereby promote the development of endometrial cancer. Yes Up-regulation of circ_PUM1 promoted the proliferation, migration and invasion of endometrial carcinoma cells. Opposite results were observed with circ_PUM1 knockdown, and the tumorigenic ability of endometrial cancer cells after circ_PUM1 knockdown was reduced compared to control cells. 32073729 OIP5-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-367-3p/HMGA2 axis] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Here we demonstrate for the first time that OIP5-AS1 expression was up-regulated in GC tissues and cell lines, which significantly correlated with unfavorable clinical characteristics and shorter survival. OIP5-AS1 regulated the activities of the PI3K/AKT and Wnt/β-catenin pathways through HMGA2. Here we demonstrate for the first time that OIP5-AS1 expression was up-regulated in GC tissues and cell lines, which significantly correlated with unfavorable clinical characteristics and shorter survival. Yes The results of in vitro and in vivo gain- and loss-of-function experiments indicate that OIP5-AS1 promoted cell proliferation and colony formation while inhibiting apoptosis of GC cells. 31959478 OIS1 LncRNA Homo sapiens cervical squamous cell carcinoma cervical squamous cell carcinoma tissues Interaction[ upregulating MTK-1] CCK8//qRT-PCR//Western Blot It was established that a reduction in OIS1 expression level in tumor tissues was apparent only in HPV-positive patients. Serum levels of OIS1 were lower in HPV-positive patients compared with that in HPV-negative patients and healthy controls, and no significant differences were observed between HPV-negative patients and healthy controls. OIS1 transfection also decreased the expression of MTK-1 in HPV-positive cancer cell lines, but not in any of the other cell lines. Yes OIS1 overexpression inhibited and MTK-1 overexpression promoted the proliferation of HPV-positive, but not HPV-negative cancer or normal cell lines. 30854069 OIP5‑AS1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR‑128‑3p/CCNG1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay OIP5‑AS1 was found to be upregulated in OC tissues and cells. OIP5‑AS1 interacted with miR‑128‑3p and functioned as an oncogene by sequestering miR‑128‑3p. In addition, CCNG1 was a target gene for miR‑128‑3p and miR‑128‑3p regulated the CCNG1‑induced effects on OC cells by downregulating CCNG1. Yes Knockdown of OIP5‑AS1 suppressed cell viability, migration, invasion and glycolysis while promoting apoptosis in OC cells. 33760168 OIP5-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Interaction[miR-186] CCK8//qRT-PCR//ELISA//Luciferase Report Assay The results demonstrated that OIP5-AS1 was upregulated in GC tissues and cell lines and that its high expression was notably correlated with aggressive clinicopathological features of GC patients.In addition, knockdown of OIP5-AS1 reduced the glucose consumption and lactate production in GC cells. In particular, OIP5-AS1 may function as a ceRNA for miR-186, and inhibition of miR-186 blocks the effects of OIP5-AS1 knockdown on aerobic glycolysis in GC cells. Yes Functionally, knockdown of OIP5-AS1 inhibited GC cell proliferation and enhanced cell apoptosis in vitro, and inhibited GC xenograft growth in vivo. 34900056 OIP5-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cell lines,blood Interaction[targeting miR-641] Western Blot//CCK8//qRT-PCR//Flow Cytometry//EdU Staining OPI5-AS1 was significantly upregulated, while miR-641 was downregulated in GC tissues and cells. OPI5-AS1 expression was remarkably inversely correlated with miR-641 in GC. Moreover, OPI5-AS1 could sponge miR-641 and regulate its expression in GC cells. Yes Functional experiments showed that OPI5-AS1 overexpression remarkably accelerated GC cell proliferation and cell cycle. 31858545 OIP5-AS1 LncRNA Homo sapiens Stomach Neoplasms cell lines Interaction[bound to EZH2] qRT-PCR Therefore, first our work probed its expression levels in GC cell lines and related normal cells by real-time quantitative polymerase chain reaction. The heightened level of OIP5-AS1 was detected in GC cell lines. Yes In terms of its cellular effects, we performed a series of functional experiments and as presented in the assays, the proliferative potential and motility was diminished. However, more apoptotic cells were induced with the introduction of OIP5-AS1 silencing. 31219209 OIP5-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[miR-153-3p/ZBTB2 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay OIP5-AS1 and ZBTB2 were strongly higher in GC tissues than noncancerous samples.OIP5-AS1 exerted its role via miR-153-3p/ZBTB2 axis in the progression of GC cells. Yes OIP5-AS1 silencing remarkably curbed cell proliferation, migration and invasion, and elevated cell apoptosis in both AGS and MKN45 cells. 32196594 OIP5-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[miR-422a/ANO1 axis] RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay In this study, we found that the expression of OIP5-AS1 was increased in GC tissues compared with that in adjacent non-cancerous tissues, which was significantly associated with shorter overall survival time of patients. Mechanistically, OIP5-AS1 functions as an oncogenic competing endogenous RNA by binding to and sequestering miR-422a to elevate the expression of anoctamin-1. In this study, we found that the expression of OIP5-AS1 was increased in GC tissues compared with that in adjacent non-cancerous tissues, which was significantly associated with shorter overall survival time of patients. Yes Knockdown of OIP5-AS1 markedly suppressed the proliferation and colony formation activities of GC cells, induced G0/G1 arrest and apoptosis of GC cells in vitro, and restrained tumor growth in vivo. 32147682 hsa_circ_0000034 CircRNA Homo sapiens Retinoblastoma RB tissues and cells regulation[miR-361-3p/STX17 axis] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay The levels of circ_0000034 and STX17 were increased and miR-361-3p level was decreased in RB tissues and cells.We demonstrated that circ_0000034 knockdown suppressed the development of RB by the modulation of miR-361-3p/STX17 axis. Yes Circ_0000034 knockdown suppressed cell proliferation, migration, invasion, autophagy, and tumor growth, and induced apoptosis in RB. 33336726 OMA1 LncRNA Homo sapiens Breast Neoplasms three pairs of BC tissues and adjacent normal tissues Interaction(miR‑1276/SIRT4 axis) RNA Pull-Down//Western Blot//Bioinformatics Analysis//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay The results revealed that the expression levels of circOMA1 were upregulated in BC tissues, and its expression was markedly associated with tumor size and lymph node metastasis. The results revealed that the expression levels of circOMA1 were upregulated in BC tissues, and its expression was markedly associated with tumor size and lymph node metastasis. Receiver operating characteristic analysis demonstrated that the expression of circOMA1 could be used to discriminate between BC tissues and adjacent normal tissues. Yes Functionally, overexpression of circOMA1 promoted the viability, migration and invasion of BC cells, whereas circOMA1 knockdown had the opposite effect. Mechanistic investigations showed that circOMA1 promoted the progression of BC by sponging microRNA (miR)‑1276 and upregulating sirtuin 4 (SIRT4) expression. 34414449 hsa_circ_0001649 CircRNA Homo sapiens Retinoblastoma RB tissues and cells Regulation[AKT/mTOR signaling pathway] CCK8//qRT-PCR//IHC//Western Blot The results indicated that hsa_circ_0001649 was decreased in RB tissues and cells, and this downregulation was associated with larger tumor size and advanced intraocular international retinoblastoma classify (IIRC) stage in RB patients. AKT/mTOR signaling pathway is involved in the cell growth alteration affected by hsa_circ_0001649. The results indicated that hsa_circ_0001649 was decreased in RB tissues and cells, and this downregulation was associated with larger tumor size and advanced intraocular international retinoblastoma classify (IIRC) stage in RB patients.Additionally, hsa_circ_0001649 could act as an independent prognostic predictor for overall survival in patients with RB. Yes Moreover, hsa_circ_0001649 inhibits cell growth and promotes cell apoptosis in RB cells. 29864621 OIP5-AS1 LncRNA Homo sapiens Breast Neoplasms cell lines regulation[ miR-340-5p/ZEB2 axis] Western Blot//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay In breast cancer, studies reported that OIP5-AS1 is upregulated in both tumor samples and cell lines (21). We first evaluated the expression levels of OIP5-AS1 in five breast cancer cell lines. Computational analysis and a dual‑luciferase reporter system identified miR‑340‑5p was the target gene for OIP5‑AS1. Further experiments verified the function of OIP5‑AS1 in cell invasion was dependent on miR‑340a‑5p through regulating target gene ZEB2. Yes In the present study, using small interfering RNA (siRNA) targeting OIP5?AS1, it was shown that knockdown of OIP5?AS1 was associated with alteration of EMT markers and suppressed migration and invasion of breast cancer cells. 32945479 OIP5-AS1 LncRNA Homo sapiens Breast Neoplasms clinical tumor tissues and cell lines regulation[miR-216a-5p/GLO1] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay OIP5-AS1 and GLO1 were highly expressed in both clinical tumor tissues and cell lines, whereas miR-216a-5p was downregulated. OIP5-AS1 knockdown suppressed the progression of breast cancer by inducing GLO1 expression via competitively binding to miR-216a-5p, suggesting that OIP5-AS1 was a hopeful biomarker for the therapy of breast cancer. Yes Knockdown of OIP5-AS1 suppressed proliferation, migration, and invasion but promoted apoptosis of breast cancer cells. OIP5-AS1 knockdown depleted tumor growth in vivo. 32916503 OIP5-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissue,cell lines regulation[YAP1/Notch/NRP1 signaling ] CCK8//qRT-PCR//ELISA//Migration Assay Overexpressed linc-OIP5, YAP1, and JAG1 were found in breast cancer cell lines MCF7 and MDA-MB-231 and the expression levels of YAP1 and JAG1 were proportional to the breast cancer tissue grades.Hence, linc-OIP5 in MDA-MB-231 breast cancer cells may act on the upstream of the YAP1/Notch/NRP1 signaling circuit to affect proliferation, migration, and tube formation of co-cultured HUVECs in a non-cellular direct contact way through JAG1 in conditioned medium. Yes MDA-MB-231 cells with linc-OIP5 knockdown led to weakened proliferation, migration, and tube formation capacity of co-cultured HUVECs. 32046779 OIP5-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells (H23) Interaction(micorRNA-34a) RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//IHC In NSCLC cells (H23), overexpression of OIP5-AS1 increased the expression levels of programmed death-ligand 1 (PD-L1). In addition, inhibition of OIP5-AS1 and overexpression of miR-34a decreased the expression levels of PD-L1, and miR-34a significantly blocked the role of overexpression of OIP5-AS1. Overexpression of OIP5-AS1 and PD-L1 promoted H23 and H22 cells proliferation, while silencing of miR-34a and OIP5-AS1 played opposite roles and eliminated the effects of overexpression of OIP5-AS1 on cell proliferation. Therefore, OIP5-AS1 was upregulated to enhance the expression of oncogenic PD-L1 by sponging miR-34a in NSCLC, leading to promoted NSCLC cell proliferation. Our study also demonstrated that OIP5-AS1 was upregulated while miR-34a was downregulated in NSCLC. Yes In addition, inhibition of OIP5-AS1 and overexpression of miR-34a decreased the expression levels of PD-L1, and miR-34a significantly blocked the role of overexpression of OIP5-AS1. Overexpression of OIP5-AS1 and PD-L1 promoted H23 and H22 cells proliferation, while silencing of miR-34a and OIP5-AS1 played opposite roles and eliminated the effects of overexpression of OIP5-AS1 on cell proliferation. 35411833 OIP5-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues interaction[miR-378a-3p] qRT-PCR//Luciferase Report Assay//RIP//Western Blot OIP5-AS1 was highly expressed in lung cancer tissues and was correlated with tumor size and tumor growth speed. Our results revealed that OIP5-AS1 acts as a growth-promoting lncRNA in lung cancer by suppressing miR-378a-3p function. Yes OIP5-AS1 overexpression increased lung cancer cell proliferation in vitro. 29897167 OIP5-AS1 LncRNA Homo sapiens Lung Neoplasms CAFs-exos Interaction( miR-142-5p/ PD-L1 axis) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Microarray Using microarray assays, opa-interacting protein 5 antisense RNA 1 (OIP5-AS1) level was highly expressed in CAFs-exos. OIP5-AS1 served as a sponge to target miR-142-5p and negatively regulated miR-142-5p expression in lung cancer cells. In addition, PD-L1 was a direct target of miR-142-5p. CAFs-derived exosomes suppressed the role of PBMCs induced-killing of lung cancer cells and promoted lung cancer progression by OIP5-AS1/ miR-142-5p/ PD-L1 axis, which provided a potential opportunity for diagnosis and treatment of lung cancer. Yes CAFs derived exosomal OIP5-AS1 reduced PBMCs induced-cell apoptosis and promoted tumor growth through decreasing miR-142-5p and up-regulating PD-L1. 34653794 OIP5-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer cell Interaction(Oct4 ) qRT-PCR//RIP//Western Blot Here, lncRNA OIP5-AS1 was found to be highly expressed in lung cancer cell spheres.Mechanistic studies revealed that lncRNA OIP5-AS1 could increase Oct4 expression by directly interacting with Oct4 mRNA and enhancing Oct4 mRNA stability. Finally, we found that the knockdown of Oct4 could rescue the promoting effects of OIP5-AS1 overexpression on the CSC-like traits of lung cancer. Yes Following experiments showed that OIP-AS1 knockdown reduced the CSC-like traits of lung cancer spheres, while overexpression of OIP-AS1 conferred the CSC-like traits in lung cancer cells by performing sphere-formation analysis, detecting stemness marker expression, and ALDH activity. 35044041 OLBC15 LncRNA Homo sapiens Triple Negative Breast Neoplasms breast cancer tissues regulation[enhancing ZNF326 degradation] qRT-PCR//RIP//FISH In the current study, we have identified a novel oncogenic lncRNA termed OLBC15 via lncRNA profiling. OLBC15 is highly expressed especially in triple-negative breast cancer. OLBC15 and ZNF326 protein expression is also negatively correlated in clinical specimens. Yes OLBC15 promoted viability and migration in breast cancer cells. Moreover, OLBC15 could accelerate metastasis and xenograft tumor growth. 32329931 OnclncRNA-626 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction[SRSF1] RNA Pull-Down//Western Blot//ISH//CCK8//qRT-PCR//RIP//RNA-seq//IHC//Transwell Assay Here, we identified a novel long noncoding RNA referred to as onclncRNA-626 (oncogenic lncRNA RP11-626H12.3), which was highly upregulated in GC tissues.Together, our findings demonstrate that onclncRNA-626 promotes GC progression by binding SRSF1; further, this lncRNA is a potential prognostic biomarker for GC patients. The high expression levels of onclncRNA-626 in GC patients predicted poor prognoses. Yes Functional assays indicated that onclncRNA-626 could promote the proliferation and metastasis of GC cells in vitro and in vivo. 31720086 hsa_circ_0000527 CircRNA Homo sapiens Retinoblastoma RB tissues and cells Interaction(miR-1236-3p/SMAD2 Pathway) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//Tube Formation Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0000527 was overexpressed in RB patients and related to advanced TNM stages, optic nerve invasion and choroidal invasion. Circ_0000527 knockdown suppressed cell proliferation, migration, invasion and angiogenesis and promoted apoptosis in RB cells in vitro. Circ_0000527 sponged miR-1236-3p, which directly targeted SMAD2. MiR-1236-3p level was decreased in RB tissues and cells. MiR-1236-3p inhibition reversed circ_0000527 knockdown-mediated effects on RB cell malignant behaviors. Moreover, miR-1236-3p overexpression suppressed RB cell progression, with SMAD2 elevation abrogated the effect. Additionally, circ_0000527 knockdown restrained tumor formation in vivo. Circ_0000527 was overexpressed in RB patients and related to advanced TNM stages, optic nerve invasion and choroidal invasion. Yes Circ_0000527 knockdown suppressed cell proliferation, migration, invasion and angiogenesis and promoted apoptosis in RB cells in vitro. 34963405 hsa_circ_0000034 CircRNA Homo sapiens Retinoblastoma RB tissues and cells Interaction(miR-361-3p/ADAM19 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay We verified that circ_0000034 expression was elevated in RB tissues and cells. Circ_0000034 acted as a sponge for miR-361-3p, which targeted ADAM19 in RB cells. Furthermore, the inhibition of miR-361-3p restored circ_0000034 knockdown-mediated impacts on viability, migration, invasion, apoptosis, and EMT of RB cells. Moreover, ADAM19 overexpression abolished the influence of miR-361-3p mimic on viability, migration, invasion, apoptosis, and EMT of RB cells. Circ_0000034 expedited RB progression through upregulating ADAM19 via sponging miR-361-3p, which indicated that circ_0000034 might a target for RB therapy. Yes Circ_0000034 silencing reduced RB growth in vivo, repressed viability, migration, invasion, and EMT, and induced apoptosis of RB cells in vitro. 32844346 OTOAP1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC cells Interaction(FOXM1) Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Invasion Assay In this study, we for the first time found that LOC653786 was upregulated in RCC tissues and cell lines, and this lncRNA promoted growth and cell cycle progression of RCC cells.Moreover, we showed that LOC653786 elevated the expression of forkhead box M1 (FOXM1) and its downstream target genes cyclin D1 and cyclin B1 in RCC cells. Reporter assay revealed that LOC653786 enhanced the transcriptional activity of FOXM1 gene promoter. Additionally, knockdown of FOXM1 attenuated the LOC653786-enhanced growth and cell cycle progression of RCC cells. In conclusion, our results demonstrate that LOC653786 accelerates growth and cell cycle progression of RCC cells via upregulating FOXM1, suggesting that the 'LOC653786/FOXM1' pathway may serve as a novel target for RCC treatment. Yes In this study, we for the first time found that LOC653786 was upregulated in RCC tissues and cell lines, and this lncRNA promoted growth and cell cycle progression of RCC cells.Meanwhile, silencing of LOC653786 suppressed RCC cell growth and cell cycle progression, which was alleviated by overexpression of FOXM1. The in vivo experiments in nude mice showed knockdown of LOC653786 repressed xenograft tumor growth and FOXM1 expression. 29552295 OSTM1-AS1 LncRNA Homo sapiens Wilms Tumor WT cells Interaction(miR-514a-3p/MELK axis) In Vivo Experiment//Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay OSTM1-AS1 and MELK were upregulated in WT cells, whereas miR-514a-3p was downregulated. MiR-514a-3p was sponged by OSTM1-AS1, and miR-514a-3p interference counteracted the tumoricidal effect of OSTM1-AS1 knockdown. MiR-514a-3p reduced WT progression by downregulating the expression of MELK, which is the target gene of miR-514a-3p. Yes OSTM1-AS1 was mostly observed in the cytoplasm, and its knockout suppressed WT cell migration and proliferation in vitro , triggered apoptosis and attenuated tumor development in vivo . 35946509 OSER1-DT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues Interaction(miR-17-5p) Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay OSER1-AS1 was down-regulated in tumor tissue and its low expression was significantly associated with poor overall survival among non-smokers in non-small cell lung cancer (NSCLC) patients.  The promoter of OSER1-AS1 was repressed by MYC, and the 3'-end of OSER1-AS1 was competitively targeted by microRNA hsa-miR-17-5p and RNA-binding protein ELAVL1. OSER1-AS1 was down-regulated in tumor tissue and its low expression was significantly associated with poor overall survival among non-smokers in non-small cell lung cancer (NSCLC) patients.  Yes Gain- and loss-of-function studies showed that OSER1-AS1 acted as a tumor suppressor by inhibiting lung cancer cell growth, migration and invasion in vitro. Xenograft tumor assays and a metastasis mouse model confirmed that OSER1-AS1 suppressed tumor growth and metastasis in vivo.  33113263 hsa_circ_0075804 CircRNA Homo sapiens Retinoblastoma RB tissues and cell lines Interaction(miR-138-5p/PEG10) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Invasion Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Circ_0075804 expression was markedly up-regulated in RB tissues and cell lines. Circ_0075804 knockdown restrained the proliferation, migration and invasion whereas promoted the apoptosis of RB cells. Circ_0075804 acted as a molecular sponge for microRNA-138-5p (miR-138-5p), and circ_0075804 silencing-induced effects were partly reversed by miR-138-5p knockdown in RB cells. MiR-138-5p interacted with the 3' untranslated region (3'UTR) of paternally expressed 10 (PEG10). Circ_0075804 positively regulated PEG10 level by sponging miR-138-5p in RB cells. PEG10 overexpression largely overturned miR-138-5p overexpression-mediated effects in RB cells. Circ_0075804 knockdown blocked xenograft tumor growth in vivo. Yes Circ_0075804 knockdown blocked xenograft tumor growth in vivo. 34633608 OSER1-DT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[miR-372-3p/Rab23 axis] qRT-PCR//Luciferase Report Assay The results of database and qRT-PCR analysis demonstrated that OSER1-AS1 was highly expressed in HCC tissues and the high expression of OSER1-AS1 was closely associated with larger tumor size, advanced tumor stages, lower disease free survival and overall survival of HCC patients.In conclusion, we found that OSER1-AS1 acted as a ceRNA to sponge miR-372-3p, thereby positively regulating the Rab23 expression and ultimately acting as a tumor suppressor gene in HCC progression. The results of database and qRT-PCR analysis demonstrated that OSER1-AS1 was highly expressed in HCC tissues and the high expression of OSER1-AS1 was closely associated with larger tumor size, advanced tumor stages, lower disease free survival and overall survival of HCC patients. Yes OSER1-AS1 knockdown significantly inhibited the proliferation, invasion and migration of HCC cells, and induced the apoptosis. 31635804 hsa_circ_0000527 CircRNA Homo sapiens Retinoblastoma RB tissues and cells Interaction(miR-27a-3p/HDAC9 Pathway) Western Blot//qPCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis Hsa_circ_0000527 and HDAC9 were upregulated, while miR-27a-3p was downregulated in RB tissues and cells. Hsa_circ_0000527 downregulation repressed RB cell proliferation and induced RB cell apoptosis. MiR-27a-3p was a target of hsa_circ_0000527, and hsa_circ_0000527 suppressed the expression of miR-27a-3p. MiR-27a-3p inhibition reversed the role of hsa_circ_0000527 downregulation. In addition, HDAC9 was a target of miR-27a-3p, and hsa_circ_0000527 indirectly regulated HDAC9 expression by targeting miR-27a-3p. MiR-27a-3p restoration inhibited RB cell proliferation and promoted apoptosis, which was reversed by HDAC9 overexpression. Hsa_circ_0000527 downregulation could inactivate the PI3K/AKT pathway. Moreover, hsa_circ_0000527 downregulation blocked tumor growth rate in vivo. Yes Hsa_circ_0000527 downregulation could inactivate the PI3K/AKT pathway. Moreover, hsa_circ_0000527 downregulation blocked tumor growth rate in vivo. 34823425 hsa_circ_0000527 CircRNA Homo sapiens Retinoblastoma RB tissues and cells Interaction(miR-98-5p/XIAP Pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay Circ_0000527 and XIAP levels were increased, while miR-98-5p level was reduced in RB tissues and cells. Besides, circ_0000527 sponged miR-98-5p to regulate RB cell progression, and miR-98-5p targeted XIAP to mediate RB cell development. Moreover, circ_0000527 modulated XIAP expression via sequestering miR-98-5p. Yes Silencing of circ_0000527 suppressed the proliferation, migration and invasion of RB cells and promoted apoptosis. In addition, knockdown of circ_0000527 inhibited tumor growth in xenograft mice. 33629639 ORLNC1 LncRNA Homo sapiens Her2-receptor positive breast cancer HER2+ breast cancer specimens and cell lines Interaction(miR-296/PTEN axis ) In Vivo Experiment//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//cell invasion assay In this study, our findings revealed downregulation of ORLNC1 in HER2+ breast cancer specimens and cell lines. Further analyses revealed that miR-296/PTEN axis is directly targeted by ORLNC1. Low levels of ORLNC1 were related to poor prognosis and advanced cancer stage. Yes Using gain- and loss-of-function assays, the ability of these tumor cells to proliferate was found to be inhibited by ORLNC1 in vitro and in vivo. 35658886 circTET1 CircRNA Homo sapiens Retinoblastoma RB tissues and cells Interaction(miR-492 and miR-494-3p through Wnt/β-catenin Signaling Pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircTET1 level was reduced, while miR-492 and miR-494-3p levels were increased in RB tissues and cells. Moreover, circTET1 impeded RB cell progression by sponging miR-492/miR-494-3p. Also, up-regulation of circTET1 restrained Wnt/β-catenin pathway via regulating miR-492 and miR-494-3p. Yes Overexpression of circTET1 inhibited proliferation, migration and invasion, and promoted apoptosis and cell cycle arrest in Y79 and WERI-Rb1 cells. Furthermore, circTET1 suppressed tumor growth in xenograft models. 33108919 hsa_circ_0000034 CircRNA Homo sapiens Retinoblastoma retinoblastoma cell lines and tissues interaction[microRNA-361-3p] Wound Healing Assay//RIP//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay In the study, these series of experiments noted an upregulation of hsa_circ_0000034 in retinoblastoma cell lines and tissues.In conclusion, our data proved that hsa_circ_0000034 promoted the oncogenicity of retinoblastoma via regulation of miR-361-3p expression, a finding that may contribute toward retinoblastoma therapeutics. Yes hsa_circ_0000034 knockdown caused a marked suppression in the proliferation and invasion of retinoblastoma cells in vitro. 32892696 circE2F3 CircRNA Homo sapiens Retinoblastoma RB tissues and cells Interaction(MiR-204-5p/ROCK1 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay Circ-E2F3 was upregulated in RB tissues and cells. MiR-204-5p could be sponged by circ-E2F3, and its inhibitor reversed the suppressive effect of circ-E2F3 silencing on RB progression. In addition, ROCK1 was confirmed to interact with miR-204-5p. MiR-204-5p regulated RB progression by targeting ROCK1. Yes Silencing of circ-E2F3 inhibited the proliferation, migration, invasion, and induced the apoptosis of RB cells in vitro, as well as reduced RB tumor growth in vivo. 33844975 OR7E156P LncRNA Homo sapiens Glioma glioma tissues Interaction(miR-143/HIF1A Axis) Immunoblotting//Transfection//ELISA//RIP In this study, we identified an upregulated lncRNA, OR7E156P, in glioma was identified. OR7E156P was intricately linked to the HIF1A pathway. Altogether a regulatory axis consisting of OR7E156P, miR-143, and HIF1A, was identified which is deregulated in glioma, and the process of the OR7E156P/miR-143/HIF1A axis modulating glioma cell invasion through ZEB1 and HUVEC tube formation through VEGF was demonstrated. Yes The silencing of OR7E156P inhibited cell invasion and DNA synthesis in vitro and tumor growth in vivo. 34422645 hsa_circ_0000527 CircRNA Homo sapiens Retinoblastoma RB tissues and cell lines regulation[miR-646/BCL-2 axis] Western Blot//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay It was demonstrated that expression level of circ_0000527 in RB samples was significantly up-regulated compared to normal tissues, while miR-646 was markedly down-regulated.Circ_0000527 sponged miR-646 to regulate the expression of BCL-2. Yes Overexpression of circ_0000527 promoted the viability, migration and invasion of RB cells, while miR-646 transfection had the opposite effects. 32266733 Or5ac15-201 LncRNA Rattus norvegicus Myocardial Reperfusion Injury MI rat model Regulation( KAT7/HMGB1 axis) Transfection//ELISA//Tunel//IF Significantly, we identified that circFoxo3 was downregulated in the MI rat model and the overexpression of circFoxo3 ameliorated MI-induced cardiac dysfunction and attenuated MI-induced autophagy in rat model. Our finding provides new insight into the mechanism by which circFoxo3 regulates MI-related cardiac dysfunction by targeting KAT7/HMGB1 axis. Yes Meanwhile, the overexpression of circFoxo3 repressed oxygen-glucose deprivation (OGD)-induced autophagy, apoptosis, inflammation, and injury of cardiomyocyte in vitro. 34880642 OR3A4P LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction[AGGF1/akt/mTOR pathway] CCK8//qRT-PCR//Transwell Assay The upregulation of OR3A4 in HCC tissues and cell lines and its prognostic significance were first identified. Rescue assays revealed that OR3A4 promoted cancer progression and angiogenesis in HCC via AGGF1/akt/mTOR. Together, present study revealed OR3A4 as a novel prognostic target for HCC, which regulated tumor progression and angiogenesis through AGGF1/akt/mTOR pathway. Yes Loss-of-function assays, including CCK-8, transwell and tube formation assay, validated OR3A4 as a promoter for HCC progression and angiogenesis. 30710550 OR3A4P LncRNA Homo sapiens Ovarian Neoplasms cell lines Regulation(KLF6) qRT-PCR//Western Blot Our study found that the knocked out OR3A4 resulted in a decrease in cell proliferation and migration level, which can be found in the downregulated expression of KLF6. We also verify the relationship between OR3A4 and circulating tumor cells in the zebra fish xenograft model, the results indicate that lncRNA OR3A4 may be involved in the resistance of ovarian cancer to complain. Yes Our study found that the knocked out OR3A4 resulted in a decrease in cell proliferation and migration level, which can be found in the downregulated expression of KLF6. We also verify the relationship between OR3A4 and circulating tumor cells in the zebra fish xenograft model, the results indicate that lncRNA OR3A4 may be involved in the resistance of ovarian cancer to complain. 34776953 circDHDDS CircRNA Homo sapiens Retinoblastoma retinas tissues and cells regulation[CircDHDDS/miR-361-3p/WNT3A Axis] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that circDHDDS was overexpressed in RB tissues and cells compared with normal retinas tissues and retinal pigment epithelial cells, correspondingly. Therefore, circDHDDS/miR-361-3p/WNT3A axis stimulated the development of RB by regulation of proliferation, cell cycle program, migration, and invasion of RB cells. Yes Furthermore, silencing of circDHDDS impeded proliferation, migration, invasion, and induced cell cycle arrest in vitro, which were abolished by knockdown of miR-361-3p. The in vivo experiments also suggested that tumor growth was inhibited by knockdown of circDHDDS. 32865704 hsa_circ_0002577 CircRNA Homo sapiens Endometrial Neoplasms EC tissue samples and cells regulation[IGF1R/PI3K/Akt pathway] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay Hsa_circ_0002577 was upregulated in EC tissue samples and cells as compared to normal controls.Our study showed that circRNA hsa_circ_002577 accelerated EC progression by acting as a miR-625-5p sponge, upregulating IGF1R and activating the PI3K/Akt pathway, suggesting the potential therapeutic use of hsa_circ_002577 in EC treatment. EC patients with higher expression of hsa_circ_0002577 showed poorer overall survival and more advanced tumor stage. Yes EC cells transfected with Lv-circRNA showed promoted proliferation, migration, and invasion, whereas the delivery of sh-circRNA exerted an opposite effect. 32847606 circFAT1 CircRNA Homo sapiens Endometrial Neoplasms EC tissues of 62 female patients  Interaction(miR-21) qRT-PCR CircFAT1 was upregulated in EC and positively correlated with miR-21 across EC tissues. In RL95-2 and HEC-1-A cells, overexpression of circFAT1 increased the expression levels of miR-21 and decreased the methylation of miR-21 gene, whereas overexpression of miR-21 did not alter the expression of circFAT1.  Yes Cell stemness analysis showed that overexpression of circFAT1 and miR-21 increased cell stemness, and miR-21 inhibition decreased cell stemness. Moreover, inhibitor of miR-21 suppressed the role of circFAT1. 34314629 PCAT19 LncRNA Homo sapiens Stomach Neoplasms GC tissue and cell lines Interaction(miR-429/DHX9) Western Blot//Invasion Assay//CCK8//qRT-PCR//Flow Cytometry//FISH//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay The PCAT19 expression in GC was significantly related to tumor size, lymph node metastasis, and pathological stage.Mechanistically, PCAT19 sponges miR-429 and promotes DHX9 expression. In addition, the transcription factor SP1 is involved in PCAT19 activation. Our results demonstrate that lncRNA PCAT19 is induced by SP1 and acts as an oncogene in GC that competitively binds to miR429 and upregulates DHX9. Moreover, patients with higher PCAT19 expression levels were more likely to have a poor prognosis for overall survival. Yes The knockdown of PCAT19 by siRNA significantly suppressed the proliferation and invasion ofGC. 34976174 PCAT1 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues regulation[upregulating p21] Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay The results indicated that lncRNA PCAT-1 was upregulated in clinical TSCC compared with peri-tumor tissues. Collectively, the present study demonstrated an oncogenic role for lncRNA PCAT-1 in TSCC; inhibition of lncRNA PCAT-1 reduced the growth, metastasis and invasion of TSCC, at least in part via the induction of p21 signaling. Yes Subsequently, lncRNA PCAT-1 was knocked down in TSCC cell lines and the resulting effect on the proliferation and apoptosis, as well as the metastatic and invasive potential of TSCC cells was investigated. 32218838 PCAT1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines Interaction[inhibiting miR-129-5p] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay PCAT-1 is significantly upregulated in OC tissues and cell lines (p < 0.05).In addition, miR-129-5p is markedly downregulated in OC and its level is inversely correlated with PCAT-1 expression in OC tumor tissues (p < 0.05). miR-129-5p inhibits proliferation and induces apoptosis in OC cell lines (p < 0.05). Furthermore, it has been demonstrated that miR-129-5p is directly targeted by PCAT-1 and miR-129-5p overexpression can effectively attenuate the effects of PCAT-1 on the proliferation and apoptosis of OC cells. Yes Overexpression of PCAT-1 promotes proliferation of OC cells and inhibits their apoptosis (p < 0.05). 30899305 PCAT1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines Interaction[targeting NEK2] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay "PCAT1 was highly expressed in OC tissues and cell lines, especially in tumor tissues with stage III-IV compared with stage I-II.PCAT1 was highly expressed in OC tissues than adjacent normal tissues. PCAT1 overexpression significantly promoted proliferative and migratory potentials, whereas inhibited apoptosis of OC cells through upregulating NEK2 expression via Wnt pathway. " PCAT1 was highly expressed in OC tissues and cell lines, especially in tumor tissues with stage III-IV compared with stage I-II. The prognosis of OC patients with higher expression of PCAT1 was significantly worse than those with lower expression. Yes In vitro experiments confirmed that PCAT1 knockdown obviously inhibited proliferative and migratory potentials, whereas induced apoptosis of OC cells. 31646554 PCAT1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and cell lines Expression[highly expressed] qRT-PCR We found elevated expression levels of PCAT1 in EC tissues and cell lines using reverse transcription qPCR (RT-qPCR). The prognostic value of PCAT1 was determined using Kaplan-Meier survival and Cox regression analysis. The results showed that higher PCAT1 expression was positively correlated with FIGO stage, myometrial invasion, lymph node metastasis, and a shorter overall survival. Yes A series of functional assays showed that the knockdown of PCAT1 by small interfering RNA (siRNA) targeting PCAT1 (siPCAT1) suppressed cell proliferation, migration and invasion, but promoted apoptosis. 31136293 PCAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues Interaction[c-Myc-AKT1-p38 MAPK signalling pathways] qRT-PCR//Western Blot Up-regulation of PCAT-1 in TCGA dataset of HNSCC was noted. We also observed increased expression of PCAT-1 in archived HNSCC patient samples as compared to adjacent non-tumor tissues. Mechanistic study revealed significant down regulation of c-Myc and AKT1 gene in both RNA and protein levels upon knockdown of PCAT-1. We observed that c-Myc and AKT1 positively correlate with PCAT-1 expression in HNSCC. Further, we observed activation of p38 MAPK and apoptosis signal-regulating kinase 1 upon knockdown of PCAT-1 which induces Caspase 9 and PARP mediated apoptosis. Targeted inhibition of PCAT-1 regresses tumor growth in nude mice. Yes Knockdown of PCAT-1 significantly reduced cell proliferation in HNSCC cell lines. 30987615 PCAT1 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow,cell lines Regulation[Wnt/β-catenin signaling pathway] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Cell Cycle Assay Our data found that PCAT-1 was highly expressed in AML-M1/2 and AML-M3 patients than normal controls and its expression was significantly up-regulated in AML cell lines Kasumi-6 and HL-60. Taken together, the present study indicated that PCAT-1 interacting with FZD6 to activate Wnt/β-catenin signaling, which may play an important role in the pathogenesis of AML. Yes The functional experiments demonstrated that knockdown of PCAT-1 remarkably inhibited proliferation, arrested cell cycle progression and triggered apoptosis of AML cells. 31814913 PCAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[regulating miR-149-5p/LRIG2 axis] qRT-PCR "The lncRNA PCAT-1 has been shown to be upregulated in human non-small cell lung cancer (NSCLC).Finally, mechanistic investigations showed that PCAT-1 upregulated the expression of miR-149-5p target gene leucine-rich repeats and immunoglobulin (Ig)-like domains 2 (LRIG2) through competitively ""spongeing"" miR-149-5p. Therefore, we concluded that PCAT-1 may promote the development of NSCLC through the miR-149-5p/LRIG2 axis." Yes Furthermore, we also found that the knockdown of PCAT-1 remarkably suppressed cell growth by inducing cell cycle arrest and apoptosis promotion in NSCLC cells. 30569478 PCAT1 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cells regulation[YY1/PCAT1/miR-216a-3p/BCL3 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay In this study, we found that PCAT1 was up-regulated in CCA tissues and cells, and the PCAT1 overexpression was associated with poor prognosis.This study revealed that PCAT1 acted as an oncogene in CCA, and the YY1/PCAT1/miR-216a-3p/BCL3 axis exhibited critical functions in CCA progression. In this study, we found that PCAT1 was up-regulated in CCA tissues and cells, and the PCAT1 overexpression was associated with poor prognosis.Moreover, PCAT1 was assessed as an independent risk factor of prognosis for CCA patients. Yes Amplified PCAT1 was found to promote tumor proliferation, migration, invasion and EMT process, whereas PCAT1 knockdown inhibited these malignant phenotypes. 33544468 PCAT1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tumors ,ccRCC cells interaction[YAP,sponging miR-656 and miR-539] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay This study found that PCAT1 levels were elevated in ccRCC tumors as well as several ccRCC cells, and knockdown of PCAT1 with siRNA (si-PCAT1) alleviated cell proliferation, migration and invasion of Caki-2 and ACHN cells.Our data indicated that PCAT1 promotes proliferation, migration and invasion of ccRCC cells by upregulating YAP via sponging miR-656 and miR-539. Yes This study found that PCAT1 levels were elevated in ccRCC tumors as well as several ccRCC cells, and knockdown of PCAT1 with siRNA (si-PCAT1) alleviated cell proliferation, migration and invasion of Caki-2 and ACHN cells. 32286142 PCAT1 LncRNA Homo sapiens Laryngeal Neoplasms LC samples, cell lines(M4E, Hep-2, M2E,NP6) Interaction[sponging miR-210-3p] Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay "The results showed that PCAT1 was significantly upregulated in tumor tissue samples compared with adjacent tissues (Figure 1A). The expression level of PCAT1 in LC cells was higher than that of NP69.PCAT1 was first identified as a novel oncogene in LC and could promote LC cell migration and invasion by sponging miR-210-3p." Yes Knockdown of PCAT1 inhibited the ability of cell migration and invasion in LC. Moreover, knockdown of PCAT1 inhibited tumor formation in vivo. 31983116 PCAT1 LncRNA Homo sapiens Osteoarthritis OA chondrocytes interaction[sponging miR-27b-3p] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//ELISA We found that the expressions of PCAT-1 were up-regulated in OA chondrocytes compared with normal chondrocytes. Based on the comparisons and analysis, we could conclude that lncRNA PCAT-1 regulated the apoptosis of chondrocytes through sponging miR-27b-3p in OA. Yes si-PCAT-1 suppressed apoptotic OA chondrocytes. Over-expression of PCAT-1 enhanced the apoptosis of normal chondrocytes. 32770398 PCAT1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues and cell lines Interaction(miR-508-3p/NFIB axis) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay PCAT1 was demonstrated to be upregulated in DLBCL tissues and cell lines. Mechanistic investigation displayed that PCAT1 interplayed with miR-508-3p, while NFIB was a target gene of miR-508-3p. Further, miR-508-3p was in a downtrend while NFIB was increased in DLBCL tissues and cell lines. MiR-508-3p overexpression repressed DLBCL cell growth and metastasis, while PCAT1 overexpression reversed the inhibitory effect of miR-508-3p on the progression of DLBCL. Moreover, NFIB silencing suppressed DLBCL cell proliferation, migration and invasion, whereas PCAT1 vector or miR-508-3p knockdown destroyed the inhibitory of si-NFIB on the progression of DLBCL. DLBCL tissues and cell lines Yes Moreover, overexpression of PCAT1 promoted DLBCL cell proliferation, migration and invasion in vitro. 33829443 PCAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung human NSCLC tissues and cell lines Interaction(VEGF/AKT/Bcl2/Caspase9 Pathway) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Invasion Assay//Transwell Assay Herein, we observed that lncRNA PCAT1 expression was upregulated in both human NSCLC tissues and cell lines, which was determined by qualitative polymerase chain reaction analysis. In conclusion, lncRNA PCAT1 interacts with DKC1 to regulate proliferation, invasion, and apoptosis in NSCLC cells via the VEGF/AKT/Bcl-2/caspase9 pathway. Yes The results showed that PCAT1 not only promoted NSCLC cell proliferation and invasion but also inhibited cell apoptosis. 33461333 PCAT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Interaction[sponging miR-326] qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Western Blot Here, we confirmed that PCAT1 was highly expressed in ESCC tissues and cell lines. Furthermore, PCAT1 could bind to miR-326, a tumour suppressor in diverse human cancers. Rescue experiments revealed that enforced expression of miR-326 attenuated the promotive effect of PCAT1 on ESCC cell growth. In addition, we discovered that PCAT1 was present in ESCC cell-derived exosomes, was higher in the serum of ESCC patients than those of healthy volunteer donors, and promoted cell growth through exosomes. Thus, our data indicate that PCAT1 promotes ESCC cell proliferation by sponging miR-326 and may serve as a non-invasive biomarker for ESCC. Yes Knockdown of PCAT1 inhibited the growth of ESCC cells, whereas overexpression of PCAT1 showed the opposite effect both in vitro and in vivo. 31273188 PCAL7 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 PCA3 LncRNA Homo sapiens Prostatic Neoplasms LNCaP cells Interaction(MIR-132-3 P/SREBP1 ) In Vivo Experiment//Western Blot//qRT-PCR//RIP//Luciferase Report Assay abnormal PCA3 expression modulated antimony-induced proliferation and cellular triglyceride and cholesterol levels. In addition, PCA3 levels were found to be inversely correlated with MIR-132-3 P levels by acting as a decoy for MIR-132-3P. Besides, SREBP1 directly interacted with MIR-132-3 P to increase cell growth and disrupt lipid metabolism by targeting its 3'UTR regions. Yes Functional studies indicated that abnormal PCA3 expression modulated antimony-induced proliferation and cellular triglyceride and cholesterol levels. 34052307 PCA3 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues and cells Interaction(miR-19a and miR-421 & PRUNE2) Cell Cycle Assay//qPCR//Colony Formation Assay We identified that PCA3 expression was significantly downregulated in both prostate cancer tissues and cells and inversely correlated with the expressions of miR-19a and miR-421. Yes Overexpression and silencing of miRNAs were achieved by synthetic miRNA mimics and inhibitors, respectively. 34839449 PCA3 LncRNA Homo sapiens Choriocarcinoma cell lines Interaction[miR-106b] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay We demonstrated that the expression of PCA3 is significantly higher in choriocarcinoma cells in contrast to normal human chorionic trophoblast cells.Our results suggest that PCA3 contributes to the progression of choriocarcinoma by acting as a ceRNA against miR-106b. Yes Furthermore, PCA3 could promote cell proliferation, migration and invasion in gestational choriocarcinoma cells and facilitated epithelial to mesenchymal transition (EMT) in vitro. 31933978 PCAT1 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues Interaction[ cyclinD1/CDK4] Western Blot//ISH//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay In the present study, the expression of LncRNA PCAT-1 was investigated. The results indicate that the expression of LncRNA PCAT-1 is up-regulated in EOC tissues compared with non-cancer controls by reverse transcription-quantitative polymerase chain reaction analysis (RT-qPCR).Finally, it is observed that PCAT-1's knockdown significantly decreased the levels of cyclin D1 and CDK4 protein expression. Taken together, LncRNA PCAT-1's oncogenic role in EOC by mediating cyclin D1/CDK4 is demonstrated, indicating it is a potential target for EOC treatment. In the present study, the expression of LncRNA PCAT-1 was investigated. The results indicate that the expression of LncRNA PCAT-1 is up-regulated in EOC tissues compared with non-cancer controls by reverse transcription-quantitative polymerase chain reaction analysis (RT-qPCR), and its higher expression is always associated with larger tumor sizes and advanced tumor grades in patients with EOC. Yes In addition, silencing PCAT-1 in the EOC cell lines SKOV3 and OVCAR3 significantly inhibits cell proliferation, migration and invasion, which is also shown by cell cycle assays, as the proportion of cells in G0/G1 phase is dramatically increased after knocking down PCAT1. 31934037 circESRP1 CircRNA Homo sapiens Endometrial Neoplasms EC cells and tissues Interaction(miR-874-3p/CPEB4 axis) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//Wound Healing Assay//Invasion Assay//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining circESRP1 was highly expressed in EC tissues and cells and was mainly localized in the cytoplasm. Mechanistically, circESRP1 sponged miR-874-3p to upregulate CPEB4 expression and ultimately contribute to EC cell proliferation and metastasis. Yes Silencing circESRP1 inhibited the proliferation, migration, and invasion of EC cells in vitro and in vivo; however, overexpression of circESRP1 had the opposite effects. Furthermore, circESRP1 regulated tumour growth in xenograft models. 35317822 PCAT18 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-4319) qRT-PCR//Wound Healing Assay//RNA Pull-Down//RIP PCAT18 expression was up-regulated in NSCLC tissues and cell lines.Moreover, luciferase reporter assays illustrated that PCAT18 regulated miR-4319 directly, and a RIP assay and RNA pull-down analysis further demonstrated that miR-4319 inhibited PCAT18 in a RNA-induced silencing complex-dependent manner. Yes Furthermore, PCAT18 silencing inhibited NSCLC cell proliferation, migration and invasion, while co-transfection with a miR-4319 inhibitor reversed these biological effects, and miR-4319 inhibited NSCLC growth in vivo.Additionally, PCAT18 silencing promoted NSCLC cell apoptosis and induced G1 stage arrest.Finally, PCAT18 silencing impaired the growth of NSCLC in vivo. 34007211 PCAT19 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues Interaction[E‐cadherin and CD46] CCK8//qRT-PCR//Western Blot It was determined that PCAT19 expression was Expression[Expression[up-expression]-expression]regulated in NSCLC tissues and also predicted poor patient survival rate. Additionally, p53 expression was Expression[down-expression]regulated in NSCLC specimens, which was negatively correlated with PCAT19 expression. Yes Moreover, in H1993 NSCLC cells, silencing of the PCAT19 gene led to an increase in the expression of p53, whilst conversely, its overexpression led to p53 Expression[down-expression]regulation. PCAT19 silencing was associated with the decreased proliferation rate of NSCLC cells, while PCAT19 overexpression led to increased proliferation. 31819778 PCAT19 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction(miR-335-5p/IER2 Axis) qRT-PCR//MTT PCAT19 is upregulated in bladder cancer tissues, while miR-335-5p is downregulated, and the expression of PCAT19 and miR-335-5p is negatively correlated. After overexpression of PCAT19, the amount of miR-335-5p in cell is decreased, and the IER2 expression is increased. The survival rate of bladder cancer patients in the PCAT19 upregulated group or miR-335-5p downregulated group was lower. Yes It can significantly promote the vitality, proliferation, migration and invasion capabilities of bladder cancer cells, and significantly inhibit cell apoptosis. 36017918 PCAT19 LncRNA Homo sapiens Glioma glioma tissues regulation[lncPCAT19/miR-142-5p/MELK signaling] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LncPCAT19 was increased in cancer tissues.Thus, lncPCAT19/miR-142-5p/MELK signaling would be a potential target for glioma treatment. Yes Knockdown of lncPCAT19 distinctly inhibited tumor growth in vivo. Interfering lncPCAT19/overexpression of miR-142-5p decreased glioma cell proliferation, colony formation and invasion, and promoted cell apoptosis by down-regulating expression of Cyclin B1, CDK2, N-cadherin, Bcl-2, and by up-regulating expression of Bax and E-cadherin. 32980991 PCAT19 LncRNA Homo sapiens Laryngeal Neoplasms laryngeal tumor tissues Regulation[ miR-182/PDK4 axis] qRT-PCR In our study, it was shown that the expression levels of PCAT19 was increased in laryngeal tumor tissues and associated with decreased overall survival. In detail, it showed that the PDK4 expression and PDHE1α phosphorylation levels were decreased upon the PCAT19 knockdown. Further studies indicated that miR-182 functioned as the bridge between PCAT19 and PDK4, which could also regulate the cellular metabolism thus affecting the cell proliferation. Furthermore, it was shown that the PCAT19/miR-182/PDK4 axis existed and regulated cell proliferation by modulating glycolysis and mitochondrial respiration.In conclusion, we demonstrated that lncRNA PCAT19 promoted cell proliferation and tumorigenesis by modulating the miR-182/PDK4 axis and the metabolism balance. PCAT19 might become a promising new target for laryngeal cancer therapeutics. In our study, it was shown that the expression levels of PCAT19 was increased in laryngeal tumor tissues and associated with decreased overall survival. Yes Using laryngeal cancer cells lines HEp-2 and AMC-HN-8, it was demonstrated that knockdown of PCAT19 decreased the cell proliferation, increased the mitochondrial respiration, and inhibited the glycolysis. Finally, we showed that the PCAT19 knockdown decreased the tumor growth in vivo, possibly through regulating the miR-182/PDK4 axis. 30868666 PCAT19 LncRNA Rattus norvegicus Neuralgia CCI rats Interaction(miR-182-5p/JMJD1A ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//ELISA PCAT19 was continuously upregulated in CCI rats. miR-182-5p was the target of PCAT19, and miR-182-5p was increased after PCAT19 knockdown. Besides, dual-luciferase reporter assay showed that JMJD1A was the target gene of miR-182-5p. The level of JMJD1A in CCI rats increased with time. After PCAT19 knockdown, JMJD1A was significantly decreased, but inhibition of miR-182-5p can reverse its levels. Yes NP behaviors such as mechanical ectopic pain and thermal hyperalgesia as well as neuroinflammation can be reduced by knocking down PCAT19. However, the injection of miR-182-5p antagomir significantly reversed the level of the NP behaviors and neuroinflammation caused by PCAT19 knockdown. 34518490 PCAT18 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Regulation[MiR-107/PTEN/PI3K/AKT Signaling Pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay PCAT18 was down-regulated in GC tissues and cells, and it had a significant diagnostic value for GC. It was also found that PCAT18 was involved in PTEN/PI3K/AKT signaling pathway through targeting miR-107. The expression of PCAT18 was highly associated with tumor size Yes The expression of PCAT18 was highly associated with tumor size, and PCAT18 was found to inhibit GC growth in vitro and in vivo. 31853187 PCAT18 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[LncRNA PCAT18/miR-301a/TP53INP1 axis ] qRT-PCR Herein, we found that PCAT18 is significantly decreases in human GC tissues and five GC cell lines. In conclusion, lncRNA PCAT18 acts as a tumour suppressor for GC and lncRNA PCAT18, miR-301a and TP53INP1 comprise a signal axis in regulating GC cell proliferation, migration and invasion. Yes Overexpression of PCAT18 inhibits cell viability, invasion and migration of GC cells and tumour growth of GC xenograft tumours. 32687182 PCAT18 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(miR-570a-3p/p16) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining//ChIP We discovered that PCAT18 is significantly decreased in paired GC tissues and correlates with a poor outcome.Mechanistic studies found that suppression of the expression of EZH2 could prevent its binding to the PCAT18's promoter region and decrease H3K27's trimethylation modification. Further mechanism research revealed that PCAT18 could regulate the expression of p16 by interacting with miR-570a-3p, thus inhibiting cell proliferation of GC. We discovered that PCAT18 is significantly decreased in paired GC tissues and correlates with a poor outcome. Yes In addition, PCAT18 could adjust cell proliferation of GC in vitro as well as in vivo. 34729108 PCAT18 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Interaction(miR-103a-3p/PCAT18 axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//IF//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Based on data from an online database, a significant decline in lncRNA PCAT18 was observed in patients with TNBC subtype compared to a population with normal breast tissue. Patients with TNBC with high PCAT18 had a lower rate of lymph node-positive metastasis than those with low PCAT18. Collectively, PCAT18 was expressed at low levels in TNBC, and PCAT18 could sponge miR-103a-3p and promote ATF7 expression, resulting in prevention of TNBC metastasis. Yes PCAT18-upregulation inhibited, while PCAT18-downregulation promoted, migration and expression of matrix metalloproteinases 9/2 (MMP9/MMP2) and uridylyl phosphate adenosine (uPA) in TNBC cells. 34787047 PCAT1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues and cancer cell lines Expression[highly expressed] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay lncRNA-PCAT1 was highly up-regulated in the colon cancer tissues and cancer cell lines. Yes The inhibition of lncRNA-PCAT1 expression further declined the migration and invasion of colon cancer cells along with the decline of cell proliferation and enhanced the chemosensitivity of colon cancer cells. 33277833 PCAT1 LncRNA Homo sapiens Breast Neoplasms Tumors and the adjacent breast tissues Interaction(RACK1/HIF-1α) In Vivo Experiment//ISH//Bioinformatics Analysis//Wound Healing Assay//Co-IP//qRT-PCR//RIP//Colony Formation Assay//Invasion Assay Extensive analyses of clinical data indicate that PCAT-1 is elevated in breast cancer patients and is associated with pathological grade, tumor size, and poor clinical outcomes. Mechanistically, PCAT-1 directly interacts with the receptor of activated protein C kinase-1 (RACK1) protein and prevents RACK1 from binding to HIF-1α, thus protecting HIF-1α from RACK1-induced oxygen-independent degradation. Extensive analyses of clinical data indicate that PCAT-1 is elevated in breast cancer patients and is associated with pathological grade, tumor size, and poor clinical outcomes.  Yes Through gain- and loss-of-function experiments, we find that PCAT-1 promotes hypoxia-associated breast cancer progression including growth, migration, invasion, colony formation, and metabolic regulation. 33850635 PCAT1 LncRNA Homo sapiens Breast Neoplasms BC cells Interaction(miR-134-3p/PITX2 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay The present study demonstrated that PCAT1 was significantly highly expressed in BC cells. The results of the dual‑luciferase assay showed that PCAT1 targeted miR‑134‑3p, and PITX2 was a potential target of miR‑134‑3p. Western blotting results demonstrated that PCAT1 knockdown significantly reduced the protein expression levels of anti‑apoptotic protein Bcl‑2, and significantly upregulated the protein expression levels of proapoptotic proteins, Bax, cleaved caspase‑3 and cleaved caspase‑9. Yes Knockdown of PCAT1 significantly inhibited cell proliferation, migration and invasion, but promoted apoptosis in human BC cell lines. 35014684 PCAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[mediating FRK] CCK8//qRT-PCR//Western Blot//ChIP PCAT1 was aberrantly elevated in tissues from patients with NSCLC.GATA6/PCAT1 may markedly maintain the stemness of NSCLC, resulting in late TNM stage and poor survival. These findings suggest that the GATA6-PCAT1-FRK axis may be a useful target for intervention in NSCLC. High levels of PCAT1 expression were more likely to present in patients with late-stage, positive CD133, and inferior overall survival. Yes PCAT1 knockdown reduced cell proliferation, stem cell properties (Sox2 and Nanog expression) of H226 and A549 cells in vitro, and repressed tumor development in vivo. 33277858 PCAT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues, cell lines Regulation[PCAT-1/miR-508-3p/ANXA10 axis] Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay Our data showed the up-regulation of PCAT-1 in different human ESCC cell lines and in clinical ESCC tissues. Yes Knockdown of PCAT-1 in ESCC cells significantly inhibited the proliferation, invasion and migration of the cancer cells. 31920393 PCAT1 LncRNA Homo sapiens Lung Neoplasms cell line(A549) Interaction[miR-324-5p] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Western Blot Mechanistic investigations demonstrated that PCAT-1 can interact with miR-324-5p and repress its expression, thereby increasing the expression of its target RAP1A. Additionally, rescue experiments revealed that PCAT-1 served as an oncogene partly through sponging miR-324-5p and Expression[up-expression]regulating RAP1A in lung cancer cells. Yes PCAT-1 overexpression remarkably promoted cell proliferation and sExpression[up-expression]pressed cell apoptosis. 32864009 PCAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC cells and tissues Interaction[ targeting miR-149-5p] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay In this study, lncRNA PCAT-1 expression was significantly upregulated in CRC cells and tissues. Of note, lncRNA PCAT-1 directly targeted miR-149-5p and miR-149-5p expression was significantly downregulated in CRC cells and tissues. Moreover, miR-149-3p reversed the suppressive effects of PCAT-1 on the cell growth of CRC cells. Yes More than that, knockdown of lncRNA PCAT-1 inhibited cell proliferation, migration and invasion while promoted cell apoptosis in CRC cells. 31646561 PCAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(ZNF217 ) qRT-PCR//Western Blot//Transwell Assay The plasma exosomal lncRNA PCAT1 was found to be significantly increased in the CRC tissues and cell lines.RIP assay results showed lncRNA PCAT1 could target ZNF217, and downregulation of lncRNA PCAT1 could decrease the protein expressions of ZNF217 in two CRC cells lines. Moreover, ZNF217 knockdown significantly decreased MTA2, MTA3, and SNAI1 expressions, but increased E-cadherin expressions in both CRC cells lines. Yes In addition, lncRNA PCAT1 knockdown significantly inhibited the adhesion and invasion of HT29 and HCT8 cells. 35809308 PCAT1 LncRNA Homo sapiens Colorectal Neoplasms HUVECs Interaction(miR-329-3p/Netrin-1-CD146 Complex) CCK8//qRT-PCR//Western Blot PCAT1 expression was upregulated in primary cell lines and their exosomes. Similarly, after exosomes were cocultured with HUVECs, the expression of the F-actin signal increased, and after PCAT1 was knocked down, the F-actin signal also decreased. PCAT1 regulates miR-329-3p/Netrin-1 and affects the biological behavior of T84 and F-actin signal expression in HUVECs. Yes PCAT1 expression was upregulated in primary cell lines and their exosomes. 36093435 PCA3 LncRNA Mus musculus Atherosclerosis foam cells Interaction(miR-140-5p/RFX7/ABCA1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qPCR//Bioinformatics Analysis PCA3 was down-regulated in foam cells, whereas miR-140-5p was highly expressed.Besides, RFX7 bound to the ABCA1 promoter and increased ABCA1 expression. Targeted relationships and interactions on the expression between miR-140-5p and PCA3 or RFX7 were elucidated. Yes Overexpression of PCA3 promoted ABCA1-mediated cholesterol efflux and reduced lipid accumulation in macrophages. 33578049 PAXIP1-DT LncRNA Homo sapiens Ovarian Neoplasms OC cell lines Interaction(miR-6744-5p/PCBP2 axis) Western Blot//Flow Cytometry//qRT-PCR//Colony Formation Assay//EdU Staining RT-qPCR analysis identified upregulation of PAXIP1-AS1 in OC cell lines. Overall, lncRNA PAXIP1-AS1 activated by H3K27ac functioned as a tumor promoter in OC via mediating miR-6744-5p/PCBP2 axis, which provided promising insight into exploration on OC therapy. Yes Functionally, PAXIP1-AS1 knockdown inhibited cell proliferation, accelerated cell apoptosis, and suppressed cell migration and epithelial-mesenchymal transition (EMT) process. 34108034 circPOLA2 CircRNA Homo sapiens Endometrial Neoplasms EC tissue Interaction(microRNA-31 methylation) CCK8//qRT-PCR The results indicated that circ_POLA2 was highly expressed in EC tissue and inversely correlated with miR-31 mRNA expression level. MSP analysis showed that circ_POLA2 overexpression increased miR-31 methylation and RT-qPCR analysis showed that circ_POLA2 overexpression decreased miR-31 mRNA expression level Yes Furthermore, circ_POLA2 overexpression also increased EC cell proliferation, while miR-31 overexpression decreased cell proliferation. Finally, circ_POLA2 overexpression reduced the effects of miR-31 overexpression. 34539866 PART1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-17-5p/TGFBETAR2 axis) In Vivo Experiment//IHC//Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay LncPART1 was highly expressed in NSCLC. miR-17-5p was down-expressed in NSCLC. miR-17-5p overexpression inhibited cell proliferation and migration invasion in NSCLC cells. LncPART1 was able to inhibit miR-17-5p expression and upregulate the expression level of TGFBETAR2. Yes LncPART1 significantly promoted cell proliferation of NSCLC cells. 33368623 PART1 LncRNA Homo sapiens Ovarian Neoplasms OC cells Interaction(PART1/miR-6884-5p/RACGAP1/RRM2 axis ) CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay In this study, from RT-qPCR analysis, we discovered that PART1 demonstrated high expression in OC cells. Furthermore, from the experimental results of RNA pull down, RIP, and luciferase reporter assays, we discovered that PART1 served as a sponge for microRNA-6884-5p (miR-6884-5p) to modulate the expression of Rac GTPase activating protein 1 (RACGAP1) and ribonucleotide reductase regulatory subunit M2 (RRM2). Yes Moreover, data from functional assays manifested that PART1 reduction hindered the proliferative, migratory, and invasive capabilities of OC cells. In vivo uncovered that PART1 knockdown impeded OC tumor growth. 35553409 PART1 LncRNA Homo sapiens Urinary Bladder Neoplasms Bladder Cancer tissues Expression[highly expressed] qRT-PCR//Microarray Prostrate androgen-regulated transcript-1 expression was upregulated in bladder cancer tissues compared to adjacent nontumor tissues. Yes Enhanced prostrate androgen-regulated transcript-1 expression promoted cell proliferation and invasion and inhibited cell apoptosis. However, knockdown of prostrate androgen-regulated transcript-1 expression inhibited cell proliferation and invasion and induced cell apoptosis. 31311442 PART1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tumours and cell lines Interaction(EZH2) qRT-PCR//Luciferase Report Assay//Western Blot The expression of PART1 and EZH2 was highly expressed in clinical OSCC tumours and cell lines.Mechanically, fused in sarcoma/translocated in liposarcoma (FUS) interacted with PART1 and EZH2. In addition, PART1 knockdown reduced the mRNA expression of EZH2, which was offset by FUS overexpression. The overexpression of FUS abrogated the effects of PART1 silence on proliferation and apoptosis of OSCC cells. The expression level of PART1 was positively correlated to the size, clinical stage and node metastasis of OSCC patients. Yes Functionally, PART1 knockdown inhibited proliferation and facilitated apoptosis of OSCC cells. 33725092 PART1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-20b-5p/BAMBI) CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Our study found obvious overexpression of PART 1 in OS tissues and cells.Further mechanistic investigations revealed that PART 1 could sponge to miR-20b-5p, which was expressed at a low level in OS tissues and cells. Importantly, miR-20b-5p overexpression inhibited OS cell proliferation, invasion, and migration. Additionally, BAMBI was confirmed as a downstream gene of miR-20b-5p, and its expression was reversely modulated by miR-20b-5p and positively modulated by PART 1. Yes Furthermore, PART 1 overexpression facilitated OS cell proliferation, invasion, and migration. 33850885 PART1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBCs and in Aldefluorhigh CSCs Interaction(miR-937-5p) Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay We demonstrate that lncRNA prostate androgen regulated transcript 1 (PART1) is enriched in TNBCs and in Aldefluorhigh CSCs, and is associated with worse outcomes among basal-like breast cancer patients. We confirmed the novel interaction between PART1 and miR-937-5p. We demonstrate that lncRNA prostate androgen regulated transcript 1 (PART1) is enriched in TNBCs and in Aldefluorhigh CSCs, and is associated with worse outcomes among basal-like breast cancer patients. Yes Knockdown of PART1 in TNBC cell lines and a patient-derived xenograft decreased cell proliferation, migration, tumor growth, and mammosphere formation potential. 34072264 PART1 LncRNA Homo sapiens Glioma glioma tissues regulation[PART1/miR-190a-3p/PTEN/PI3K/AKT axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay In the present study, we elucidated a pivotal role and molecular mechanism of lncRNA PART1 in glioma cell lines.It was found that PART1 was significantly downregulated in glioma tissues compared to normal tissues according to TCGA data and our RT-qPCR results. Taken together, the current study revealed a PART1/miR-190a-3p/PTEN/PI3K/AKT axis in glioma and provided novel insights for understanding the complex lncRNA-miRNA network in glioma. Yes The cell-based assays showed that PART1 suppressed cell proliferation and triggered cell apoptosis in glioma cell lines. 32099409 PART1 LncRNA Homo sapiens Glioma glioma cell lines Interaction(miR-374b/SALL1 axis) In Vivo Experiment//IHC//Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of lncRNA PART1 and SALL1 were down-regulated and miR-374b was up-regulated in different glioma cell lines. LncRNA PART1 targeted miR-374b to promote SALL1 expression. The knockdown of miR-374b inhibited glioma cell proliferation and migration and EMT by SALL1. Yes Overexpression of lncRNA PART1 inhibited glioma cell proliferation, migration, and epithelial mesenchymal transition (EMT). 35490895 PART1 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues and cell lines Interaction(miR-122) Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//cell invasion assay PART1 expression was upregulated in pancreatic cancer tissues and cell lines. PART1 was found to serve as a molecular sponge of miR-122, and miR-122 inhibition partially reversed the inhibitory phenotypes of PART1 knockdown on pancreatic cancer cells. High PART1 expression was closely correlated with tumor size, T classification, clinical stage, and vascular invasion, and predicted a poor overall survival. Yes PART1 knockdown significantly suppressed cell proliferation and invasion abilities of pancreatic cancer but promoted cell apoptosis. 33865422 circSLC6A6 CircRNA Homo sapiens Endometrial Neoplasms EC tissues and cells Interaction(miR-497-5p/ PI4KB/hedgehog pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay We found that circSLC6A6 was highly expressed in both EC tissues and cells. Besides, a mechanistic study demonstrated that circSLC6A6 could regulate tumor-associated signaling PI4KB/hedgehog pathway by sponging miR-497-5p. Yes And circSLC6A6 promoted the proliferation, migration, and invasion of EC cells in vitro. In vivo, circSLC6A6 promoted tumor growth. 34258297 PART1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-149-5p/MAP2K1 Axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay PART1 and MAP2K1 expression were greatly increased and miR-149-5p level was decreased in HCC tissues. PART1 promoted proliferation, migration and invasion of HCC cells by regulating miR-149-5p/MAP2K1 axis. Yes Functional analysis revealed that the si-PART1 inhibited proliferation, migration and invasion of HCC cells. 32547213 PART1 LncRNA Homo sapiens Intervertebral Disc Degeneration Interaction(miR-190a-3p) Western Blot//Flow Cytometry//qRT-PCR//MTT//ELISA . Expression levels of lncRNA PART1 in LPS-treated NP cells were found to be higher compared with those in the control groups. miR-190a-3p directly targeted lncRNA PART1. Collectively, these results suggest that PART1 accelerates the progression of IDD by directly targeting miR-190a-3p, which provides a novel target for IDD diagnosis and treatment. Yes PART1 knockdown enhanced cell viability, reduced cell apoptosis, inhibited inflammatory factor secretion and promoted ECM degradation in LPS-stimulated NP cells. However, transfection with the miR-190a-3p inhibitor reversed the aforementioned PART1 knockdown-induced alterations in cell viability, apoptosis, inflammatory cytokine and ECM degradation. 33376513 PART1 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and cell lines interaction[miR-503-5p] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The low PART1 expression and high miR-503-5p expression were found in TSCC tissues and cell lines (CAL-27 and SCC9).LncRNA PART1 played a cancer-suppressing role in TSCC by targeting miR-503-5p, which provided a potential target for TSCC treatment. PART1 expression was positively correlated with patients' prognosis. Yes Moreover, PART1 facilitated apoptosis, inhibited proliferation, invasion and migration of TSCC cells, and these influences were impeded by miR-503-5p overexpression. 33116583 PART1 LncRNA Homo sapiens lung squamous cell carcinoma LSCC tissues and cell lines Interaction(miR-185-5p/Six1 axis) Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay//Cell Viability Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay We found that PART1 was overexpressed in both LSCC tissues and cell lines. Mechanistically, we identified that PART1 acted as a sponge of miR-185-5p, and sineoculis homeobox homolog 1 (Six1) was a direct downstream target of miR-185-5p. Moreover, restoration of miR-185-5p or silencing of Six1 partially abolished the oncogenic effect of PART1 in LSCC cells. Clinically, The areas under the receiver operating characteristic (ROC) curve of PART1, miR-185-5p, and Six1 were 0.7857, 0.7332, 0.8112, respectively. Yes Functional studies revealed that PART1 knockdown significantly suppressed cell proliferation, invasion and migration but enhanced apoptosis in LSCC cells, whereas overexpression of PART1 showed the opposite results. 33300377 circIFT80 CircRNA Homo sapiens Endometrial Neoplasms ECa tissues and cells Interaction(miR-545-3p/FAM98A signaling) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Circ-IFT80 and FAM98A were up-regulated, and miR-545-3p was down-regulated in ECa tissues and cells.Moreover, circ-IFT80 harbored a binding site for miR-545-3p, and the effects of circ-IFT80 were mediated by miR-545-3p. FAM98A was a direct target of miR-545-3p, and miR-545-3p hindered ECa cell progression via targeting FAM98A. Yes Knockdown of circ-IFT80 blocked proliferation, migration, invasion and angiogenesis and promoted apoptosis in ECa cells. 34783205 PART1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR‑18a‑5p/SOX6 signaling axis) Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis It was found that PART1 and SOX6 were both downregulated in ESCC tissues and cells, and their low expression levels were associated with TNM stage, lymph node metastasis and poor prognosis in patients with ESCC. Forkhead box protein P2 (FOXP2) exhibited low expression level in ESCC tissues, and its expression was positively correlated with PART1 expression level in ESCC tissues. FOXP2 was found to bind to the promoter region of PART1 to regulate its expression in ESCC cells. Mechanistically, PART1 functions as a competing endogenous (ce)RNA by sponging miR‑18a‑5p, resulting in the upregulation of the downstream target gene, SOX6, coupled with the inactivation of the β‑catenin/c‑myc signaling axis, to suppress ESCC cell proliferation and invasion. It was found that PART1 and SOX6 were both downregulated in ESCC tissues and cells, and their low expression levels were associated with TNM stage, lymph node metastasis and poor prognosis in patients with ESCC. Yes Functionally, PART1 overexpression suppressed cell proliferation and invasion, whereas PART1 downregulation promoted cell proliferation and invasion in the ESCC cell lines. 33432363 circATAD1 CircRNA Homo sapiens Endometrial Neoplasms EC samples. Interaction(miR-10a through methylation) qRT-PCR//Transwell Assay We found that circ-ATAD1 was downregulated in EC, while miR-10a was upregulated in EC. An inverse correlation between circ-ATAD1 and miR-10a was observed across EC samples. In EC cells, circ-ATAD1 overexpression decreased miR-10a expression and increased miR-10a gene methylation. Yes Transwell assay analysis showed that circ-ATAD1 overexpression totally reversed the enhancing effects of miR-10a on EC cell invasion and migration. Circ-ATAD1 is downregulated in EC and may suppress EC cell invasion and migration by downregulating miR-10a through methylation. 34406448 circZNF124 CircRNA Homo sapiens Endometrial Neoplasms EC tissues and cells Interaction(miR-199b-5p/SLC7A5 pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//IHC//Transwell Assay CircZNF124 and SLC7A5 expression were significantly increased, while miR-199b-5p was decreased in EC tissues and cells compared with normal endometrial tissues or cells. CircZNF124 regulated SLC7A5 expression by binding to miR-199b-5p. MiR-199b-5p inhibitors or SLC7A5 overexpression attenuated circZNF124 silencing-mediated EC malignant progression. Furthermore, SLC7A5 absence inhibited tumor growth in vivo. CircZNF124 expression was closely associated with EC severity and lymph node metastasis. Yes Additionally, circZNF124 depletion repressed cell proliferation, leucine uptake, migration and invasion in both HEC1A and Ishikawa cells. 34145797 PART1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues or cells Interaction(miR-503-5p/FOXK1 axis) qRT-PCR//Wound Healing Assay//Tunel//Transwell Assay Increased expression of PART1 and FOXK1 was observed in OC tissues or cells, whereas miR-503-5p was downregulated. Meanwhile, miR-503-5p was a target of PART1, and FOXK1 was a direct target gene of miR-503-5p. Both downregulation of miR-503-5p and upregulation of FOXK1 partly relieved the suppressive effects of PART1 knockdown on the oncogenicity of OC in vitro. Yes PART1 silencing or miR-503-5p overexpression repressed the cell viability, migration and invasion, and protomed apoptosis. 35100978 PART1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-590-3p/ HMGB2 Axis] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay PART1 expression was found to be significantly upregulated in HCC tissues and cells. Our results provided evidence that PART1 serves as oncogenic lncRNA through sponging miR-590-3p to upregulate HMGB2 expression in HCC. Yes Functionally, silencing of PART1 significantly suppressed HCC cell proliferation, colony formation and invasion in vitro, while forcing PART1 exerts opposite biological effects. 32982307 PAXIP1-DT LncRNA Homo sapiens Glioma glioma tissues,cell lines Interaction[upregulate KIF14] Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay//Transwell Assay//ChIP Firstly, we identified differentially expressed lncRNA PAXIP1-AS1 as associated with glioma based on bioinformatic data. Then, validation experiments were conducted to confirm a high expression level of lncRNA PAXIP1-AS1 in glioma tissues and cells, accompanied by upregulated KIF14. Yes Overexpression of lncRNA PAXIP1-AS1 enhanced migration, invasion, and angiogenesis of human umbilical vein endothelial cells in glioma by recruiting the transcription factor ETS1 to upregulate the expression of KIF14, which was further confirmed by accelerated tumor growth in nude mice. 31823805 circRIMS CircRNA Homo sapiens Endometrial Neoplasms EC and paired non-tumor tissue samples Interaction() BrdU//qRT-PCR//Cell Proliferation Assay circRIMS was upregulated in EC, while miR-505 was downregulated in EC.circRIMS and miR-505 were inversely correlated across both EC and non-tumor tissues. In EC cells, circRIMS overexpression decreased miR-505 expression and increased miR-505 gene methylation. Yes BrdU assay showed that circRIMS overexpression increased cell proliferation and reduced the inhibitory effects of miR-505 overexpression on cell proliferation. circRIMS may downregulate miR-505 through methylation to increase cell proliferation. 35695664 PAXIP1-DT LncRNA Homo sapiens Pulmonary Arterial Hypertension lung tissues and serum of MCT-induced PAH rats Interaction(ETS1/WIPF1/RhoA axis) In Vivo Experiment//ChIP//Western Blot//Transfection//Wound Healing Assay//Co-IP//CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU//Transwell Assay It was found that the expression of PAXIP1-AS1 and RhoA was remarkably higher in both lung tissues and serum of MCT-induced PAH rats, as well as in hypoxia-induced hPASMCs.PAXIP1-AS1 positively regulated WIPF1 via recruiting transcriptional factor ETS1, of which knockdown reversed PAXIP1-AS1-mediated biological functions. Co-immunoprecipitation validated the WIPF1/RhoA interaction. Yes PAXIP1-AS1 knockdown remarkably suppressed hypoxia-induced cell viability and migration of hPASMCs. In vivo experiments further revealed the role of PAXIP1-AS1 in PAH pathogenesis. 34245091 hsa_circ_0023404 CircRNA Homo sapiens Endometrial Neoplasms three endometrial cancer cell lines Interaction(miR-217/MAPK1 axis) Western Blot//Transfection//Migration Assay//qRT-PCR//Colony Formation Assay//Invasion Assay//Transwell Assay RT-qPCR showed that the levels of hsa_circ_0023404 and MARK1 mRNA were upregulated, but mirR-217 was decreased in three endometrial cancer cell lines. hsa_circ_0023404 exerts a tumor-promoting role in endometrial cancer by regulating miR-217/MARK1 axis. hsa_circ_0023404 inhibit miR-217 as sponge which inhibit endometrial cancer cell growth and metastasis. MARK1 is downstream target of miR217 and upregulated by hsa_circ_ 0023404/miR-217 axis and involved in the endometrial cancer progression. Yes Knockdown of hsa_circ_0023404 by siRNA markedly increased the level of miR-217 and reduced the proliferation of the Ishikawa cells. It also inhibited the cell migration and invasion. Anti-miR-217 can reverse the promoted proliferation, migrations and invasion of Ishikawa cells mediated by si-circ_0023404. si-MARK1 restored the inhibited cell proliferation, migration and invasion of the co-transfected Ishikawa cells with si- circ_0023404 and anti-miR-217. 36352482 PAX8-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tumor tissue and PTC cells Interaction[MYC ] CCK8//qRT-PCR//Western Blot Expression levels of PAX8‑AS1:28 and PAX8 were lower in PTC tumor tissue and PTC cells than those in healthy tissue and normal cells. Yes PAX8‑AS1:28 silencing reduced the expression level of PAX8 and promoted tumor cell growth, while PAX8‑AS1:28 overexpression increased the expression level of PAX8 and inhibited tumor cell growth. MYC silencing increased expression levels of PAX8‑AS1:28 and PAX8 and inhibited tumor cell growth, while MYC overexpression decreased expression levels of PAX8‑AS1:28 and PAX8 and promoted tumor cell growth. 30720110 PAX8-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary human PTC cell lines (K1, TPC-1, and IHH4) Interaction(miR-96-5p/PKN2 Axis) qRT-PCR//MTT//Western Blot The expression of PAX8-AS1 was decreased in PTC tissues and cells. PAX8-AS1 overexpression inhibited the proliferation of PTC cells and promoted cell apoptosis. In addition, PAX8-AS1 bonds with miR-96-5p, whose downregulation elevated the expression of PKN2 in PTC cells. Importantly, according to the rescue experiments, PKN2 silencing partially reversed the inhibitory effects of PAX8-AS1 expression on PTC cell proliferation and apoptosis. Yes PAX8-AS1 overexpression inhibited the proliferation of PTC cells and promoted cell apoptosis. 34745257 hsa_circ_0011324 CircRNA Homo sapiens Endometrial Neoplasms cancer tissues Interaction( hsa-miR-497/16-5p) IHC//Western Blot//Bioinformatics Analysis//Migration Assay//CCK8//qRT-PCR//FISH//RIP//RNA-seq//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Only the expression of hsa_circ_0011324 was significantly increased in cancer tissues. RNA22 website and Targetscan website were applied to analyze downstream genes regulated by hsa_circ_0011324. Then, the expression of downstream genes was detected in EC tissues. Results indicated hsa-miR-497/16-5p expression were down-regulated, and mechanistic target of rapamycin kinase (mTOR) was up-regulated in EC. Furthermore, hsa_circ_0011324 regulated mTOR expression and cell functions by affecting hsa-miR-497/16-5p. And the potential mechanism was hsa_circ_0011324 competes with mTOR to directly bind to hsa-miR-497/16-5p. Yes Results revealed hsa_circ_0011324 overexpression promoted cell proliferation, migration, and invasion; while silence of hsa_circ_0011324 had opposite effect on cell functions. RNA22 website and Targetscan website were applied to analyze downstream genes regulated by hsa_circ_0011324. 35259044 PAX8-AS1 LncRNA Homo sapiens Leukemia, Myeloid AML patients and HL60 cells Interaction(miR-378g/ERBB2 Axis) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis The highly expressed PAX8-AS1 was observed in AML patients and HL60 cells, which was more evident in refractory/recurrent AML patients and HL60/ADM cells. PAX8-AS1 directly targeted miR-378g, whose expression pattern is opposite to that of PAX8-AS1 in AML. MiR-378g upregulation abrogated the effects of PAX8-AS1 overexpression on HL60 cells. MiR-378g downregulation offset PAX8-AS1 silencing-induced effects on HL60/ADM cells. Moreover, ERBB2 was recognized as the target of miR-378g, with a higher expression in HL60/ADM cells than in HL60 cells. Yes PAX8-AS1 overexpression increased viability and Bcl-2 expression, while diminishing apoptosis, Bax, and C Caspase-3 expressions in HL60 cells. However, the abovementioned aspects were oppositely impacted by PAX8-AS1 silencing in HL60/ADM cells. 36248434 circWEE1 CircRNA Homo sapiens Endometrial Neoplasms patients with EC Interaction(miR-195-5p/VEGF ) Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Microarray//IP//Transwell Assay The expression of circWEE1 and EIF4A3 levels were increased in patients with EC. Next, we verified that eIF4A3 binds to the circWEE1 mRNA transcript, circWEE1 served as a sponge that directly targeted miR-195-5p. Bioinformatics prediction forecast that miR-195-5p directly targeted VEGF at 3'-UTR, which was confirmed by luciferase reporter assay. Yes Over-expression of circWEE1 or down-regulation of miR-195-5p promoted cell migration and proliferation in EC. 35546509 PAX1-AS1-N LncRNA Homo sapiens Diabetic Nephropathies blood regulation[PAX8-AS1-N/miR-17-5p/STAT3 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//ELISA We found that the lncRNA PAX8-AS1-N was lowly expressed and high expression of VEGF/TGF-β1/8-OhdG and high level of albuminuria in DN patients and high-glucose-treated MPC5.Above that, we found that lncRNA PAX8-AS1-N/miR-17-5p/STAT3 axis was closely related the progression of DN, which could be a potential target for treating DN patients.We found that the lncRNA PAX8-AS1-N was lowly expressed and high expression of VEGF/TGF-β1/8-OhdG and high level of albuminuria in DN patients and high-glucose-treated MPC5. Above that, we found that lncRNA PAX8-AS1-N/miR-17-5p/STAT3 axis was closely related the progression of DN, which could be a potential target for treating DN patients. Yes Besides, we proved that LV-PAX8-AS1-N decreased MPC5 apoptosis and suppressed the expression of VEGF/TGF-β1/8-OhdG in vitro experiment. 32633379 PAS1 LncRNA Homo sapiens Breast Neoplasms BC samples Interaction(DNMT1-PAS1-PH20 axis ) In Vivo Experiment//RNA Pull-Down//Western Blot//ISH//Co-IP//Migration Assay//qRT-PCR//RIP Meanwhile, PAS1 recruits SUV39H1 to trigger the H3K9 methylation of PH20, resulting in its silencing. Functionally, PAS1 inhibits breast cancer growth and metastasis, at least partially, by suppressing PH20. Combination therapy of decitabine and PAS1-30nt-RNA, which directly binds to SUV39H1, effectively blocked breast cancer growth and metastasis in mice. Yes Functionally, PAS1 inhibits breast cancer growth and metastasis, at least partially, by suppressing PH20. 35307730 PART1 LncRNA Homo sapiens Osteoarthritis OA cartilage tissues Regulation[miR-373-3p/SOX4 axis ] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP PART1 and SOX4 were up-regulated while miR-373-3p was down-regulated in OA cartilage tissues and chondrocytes. Yes PART1 silencing hindered cell proliferation and ECM degradation, and triggered cell apoptosis in OA chondrocytes. 31646607 PART-1 LncRNA Homo sapiens Osteoarthritis cartilage tissues Regulation[TGFBR2/Smad3 signalling ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, the PART-1 expression level was down-regulated in the OA cartilages. Collectively, the study revealed that lncRNA PART-1 regulates the apoptosis of chondrocytes in OA by acting as a sponge for miR-590-3p, which subsequently regulates TGFBR2/Smad3 signalling. Yes Silence of PART-1 decreased the cell viability and promoted chondrocytes apoptosis. 31571401 PART1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues regulation[PDGFRβ/PI3K/Akt signaling pathway] RNA Pull-Down//ISH//qRT-PCR//RIP//ChIP In our cohort, PART1 was identified as a significant downregulated lncRNA in gastric cancer tissues by qPCR and in situ hybridization (ISH), and its low expression was significantly correlated with postoperative metastasis and short overall survival time after surgery. In a chain reaction, chromatin immunoprecipitation (ChIP) assay additionally illustrated that PLZF upregulation increased the enrichment of EZH2 and H3K27 trimethylation in the platelet-derived growth factor (PDGFB) promotor, thereby inhibition of PDGFB and the subsequent PDGFRβ/PI3K/Akt signaling pathway. In our cohort, PART1 was identified as a significant downregulated lncRNA in gastric cancer tissues by qPCR and in situ hybridization (ISH), and its low expression was significantly correlated with postoperative metastasis and short overall survival time after surgery. Yes Through the results of gain-of-function experiments, PART1 was confirmed as a tumor suppressor that can decrease not only cell viability, migration, and invasion in vitro but also tumorigenesis and tumor metastasis in vivo. 32901105 hsa_circ_0005797 CircRNA Homo sapiens Endometrial Neoplasms EC biological samples and cell lines Interaction(miR-298/CTNND1 signaling) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//cell invasion assay In the present study, we found that hsa_circ_0005797 expression was significantly increased in EC biological samples and cell lines, whereas its downregulation inhibited in vitro tumor cells proliferation and invasion phenotypes and suppressed tumor formation in nude mice. In mechanism, we characterized hsa_circ_0005797 as an miR-298 sponge, with CTNND1 identified as a target of miR-298. Yes In the present study, we found that hsa_circ_0005797 expression was significantly increased in EC biological samples and cell lines, whereas its downregulation inhibited in vitro tumor cells proliferation and invasion phenotypes and suppressed tumor formation in nude mice. 34852711 PART1 LncRNA Homo sapiens Breast Neoplasms breast cancer cells interaction[Targeting miR-4516] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay In this study, we showed that lncRNA PART1 was highly expressed in breast cancer cells.Here, we demonstrated that PART1 can bind to miR-4516 to decrease the expression of miR-4516 and promote the development of breast cancer. Yes Knockdown of PART1 induced decreased proliferation, invasion and migration of breast cancer cells. 32922076 circSEPT9 CircRNA Homo sapiens Endometrial Neoplasms EC tissues Interaction(miR-186) qRT-PCR//Transwell Assay CircSEPT9 was upregulated in EC, and miR-186 was downregulated in EC. MiR-186 and circSEPT9 were inversely correlated across EC tissue samples, but not non-tumor samples.Overexpression of circSEPT9 decreased the expression levels of miR-186 and increased the methylation of miR-186 gene. Yes CircSEPT9 increased cell invasion and migration and suppressed the role of miR-186 in inhibiting cell behaviors. 35777791 PART1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Regulation[targeting miR-150-5p/miR-520h/CTNNB1 and activating Wnt/β-catenin pathway] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay According to experiment findings, PART1 was up-regulated in CRC tissues and cell lines. Mechanistically, PART1 sponged miR-150-5p/miR-520 h to up-regulate CTNNB1, thus activating Wnt/β-catenin pathway in CRC. In summary, PART1 could up-regulate CTNNB1 via sponging miR-150-5p/miR-520 h. Yes Inhibition of PART1 hindered CRC cell proliferation, invasion and migration, while promoting CRC cell apoptosis. Experiments in vivo also validated this result. 31669140 PART1 LncRNA Homo sapiens Colorectal Neoplasms serum regulation[miR-150-5p/LRG1 axis] qRT-PCR Also, compared with 10 healthy controls, the level of PART1 was increased, whereas miR-150-5p expression was diminished in the serum of 10 colorectal cancer patients. In conclusion, PART1 facilitates the malignant progression of colorectal cancer via miR-150-5p/LRG1 pathway. Yes Cell proliferation and migration, along with epithelial-mesenchymal transition, was promoted by PART1 overexpression. 31898365 PPM1A-AS LncRNA Homo sapiens T-cell acute lymphoblastic leukemia 10 T-ALL samples Regulation(Notch4, STAT3 and Akt) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RNA-seq//Cell Apoptosis Assay//EdU Staining The lncRNA PPM1A-AS was screened out for its significant up-regulation in 10 T-ALL samples of different subtypes than healthy human thymus extracts. Besides, the PPM1A-AS expression levels in 3 T-ALL cell lines are markedly higher than that in CD45+ T cells of healthy human. Finally, we verified that PPM1A-AS can regulate core proteins, Notch4, STAT3 and Akt, of 3 important signaling pathways related to T-ALL. Yes We further demonstrate that PPM1A-AS can promote cell proliferation and inhibit cell apoptosis in vitro and can influence T-ALL growth in vivo. 34746000 PPP1R13B-DT LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma patients Regulation(Rab5 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//ELISA Mechanistically, HITT is physically associated with Rab5 at switch I via 1248-1347 nt and suppresses β1 integrin endocytosis and subsequent cancer metastasis by interfering with guanine nucleotide exchange factors (GEFs) for Rab5 binding. Our data show that HITT expression is inversely associated with advanced stages and poor prognosis of lung adenocarcinoma patients with area under receiver operating characteristics (ROC) curve (AUC) 0.6473. Yes Further study reveals that both endogenous and exogenous HITT inhibits single-cell migration by repressing β1 integrin endocytosis in lung adenocarcinoma. 35017116 PPP1R13B-DT LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-602) Flow Cytometry//RNA Pull-Down Our data illustrated that HITT was highly upregulated and mature miR-602 was downregulated in GC. No alteration in premature miR-602 in GC was observed. HITT was located in both nucleus and cytoplasm, and it can directly interact with miR-602. In addition, overexpression of HITT in GC cells increased the expression levels of mature miR-602 but not premature miR-602. In conclusion, HITT may promote GC cell apoptosis by suppressing the maturation of miR-602. Yes Overexpression of HITT further increased GC cell apoptosis and suppressed the role of miR-602 in inhibiting GC cell apoptosis. 35852131 PWRN1 LncRNA Homo sapiens Glioblastoma GBM tumors and GBM cell lines regulation[hsa-miR-21-5p] qRT-PCR//Luciferase Report Assay PWRN1 was downregulated in both human GBM tumors and GBM cell lines.Overexpressing PWRN1 has tumor inhibitory effect on GBM cells, likely via reversely suppressing the expression of tumor oncogenic factor of hsa-miR-21-5p. Yes In LN-229 and U-251, PWRN1 overexpression suppressed cancer cell proliferation and migration in vitro, and xenograft growth in vivo. 32753949 QKILA LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[QKI] qRT-PCR//Transwell Assay//RIP//Western Blot The lncRNA Loc490 and the RNA-binding protein Quaking (QKI) were downregulated in GC tissues and lymph node metastases compared with normal tissues, and the levels of these two genes correlated positively with one another. Loc490 expression correlated negatively with lymph node metastasis and vein/nerve invasion, while it correlated positively with overall and disease-free survival. Yes Overexpression of Loc490 inhibited GC cell proliferation, invasion and metastasis and exerted strong antitumor effects in vivo, while silencing of QKI antagonized these effects. 32931453 QCJ-SCHIP1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and adjacent NCTs,cell lines(GEO, SNU-C1, Colo205, HCT-116, HT-29, SW480) Expression[lower expressed] CCK8//qRT-PCR//RNA-seq We found that IQCJ-SCHIP1-AS1 expression was significantly decreased in CRC tissues compared with paired NCTs IQCJ-SCHIP1-AS1 down-regulation was correlated with poor differentiation (P=0.025), advanced depth of tumor (P=0.022), lymphatic invasion (P=0.010), advanced tumor stage (P=0.006), and poor prognosis (P=0.0027) in CRC patients. The Cox proportional hazards model demonstrated that IQCJ-SCHIP1-AS1 expression was an independent prognostic factor for CRC (HR =0.247, 95% CI: 0.081-0.752, P=0.014). Yes Moreover, knockdown of IQCJ-SCHIP1-AS1 promoted CRC cell proliferation through increasing cell cycle progression and impairing cell apoptosis. 31205916 PXN-AS1-L LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[regulating PXN] qRT-PCR//Western Blot PXN-AS1-L was up-regulated in NSCLC tissues compared with noncancerous lung tissues, and PXN-AS1-L was further up-regulated in NSCLC bone metastasis tissues. Our data revealed that PXN-AS1-L is up-regulated and acts as an oncogene in NSCLC via up-regulating PXN. Increased expression of PXN-AS1-L was positively associated with advanced TNM stages and poor prognosis. Yes Gain-of-function and loss-of-function assays showed that PXN-AS1-L increased cell viability, promoted cell proliferation, inhibited cell apoptosis, and promoted cell migration of NSCLC cells. Xenograft assays showed that PXN-AS1-L also promoted NSCLC tumor growth in vivo. 30679933 PXN-AS1-L LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction[upregulating SAPCD2] RNA Pull-Down//Western Blot//qPCR//CCK8//RIP//Luciferase Report Assay//Transwell Assay Here, we determined that PXN-AS1-L is upregulated in NPC tissues and cell lines. In conclusion, lncRNA PXN-AS1-L is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction. Yes PXN-AS1-L overexpression promotes NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. PXN-AS1-L silencing suppresses NPC cell proliferation, migration, and invasion in vitro. 31173488 PXN-AS1 LncRNA Homo sapiens Glioblastoma GBM tissues and cells regulation[EZH2-mediated methylation of DKK1] IHC//Western Blot//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//EdU Staining//IF Our present study indicated that PXN-AS1 was highly expressed in GBM tissues and cells.Interestingly, we found that PXN-AS1 could recruit EZH2 to mediate the H3K27me3 level of DKK1 promoter. Restoration experiments manifested that DKK1 knock-down counteracted PXN-AS1 depletion-mediated repression in GBM cell growth. Yes Besides, the knock-down of PXN-AS1 was closely associated with the inhibitory proliferation and inducing apoptosis of GBM cells. PXN-AS1 inhibition was also found to restrain GBM tumour growth. 32329150 PXN-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines Interaction[miR-3064] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay Importantly, lncRNA PXN-AS1 expression was downregulated in PC samples, and it directly interacted with miR-3064 and suppressed its levels in PC cells. Yes Enforced expression of PXN-AS1 remarkably decreased cell proliferation, invasion and sphere formation, while re-expression of miR-3064 abrogated these effects of PXN-AS1. 31488171 PWRN2 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines regulation[miR-325/DDX5 axis] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay It was found that PWRN2 was upregulated and miR-325 was downregulated in PTC tissues and cell lines.Moreover, Luciferase assay and rescue experiments confirmed that the PWRN2/miR-325/DDX5 axis aggravated the development of PTC. Yes MiR-325 level was negatively correlated with PWRN2 level in PTC samples, and the overexpression of PWRN2 stimulated proliferative and migratory potentials in PTC cells, which were partially abolished by overexpression of miR-325. 33090407 PWRN1 LncRNA Homo sapiens Osteosarcoma osteosarcoma cells and human tumors interaction[hsa-miR-214-5p] qRT-PCR We found that PWRN1 was downregulated in both osteosarcoma cells and human tumors.Our data provide new insights into the epigenetic axis of PWRN1/miR-214-5p in regulating osteosarcoma progression and chemoresistance. PWRN1 downregulation was correlated with advanced stage, metastasis, and low survival rate in cancer patients. Yes PWRN1 overexpression in osteosarcoma cells significantly inhibited their proliferation, cisplatin chemoresistance, and in vivo growth. 32870579 PWAR6 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC samples Interaction(EZH2/YAP1) qRT-PCR//ChIP In this study, we identified PWAR6 as a frequently down-regulated lncRNA in PDAC samples as well as a panel of pancreatic cancer cell lines. Mechanistically, PWAR6 could bind to methyltransferase EZH2, a core component of Polycomb Repressive Complex 2 (PRC2) in regulating gene expression, and scaffold EZH2 to the promoter region of YAP1, resulting in epigenetic repression of YAP1. Down-regulated PWAR6 was associated with multiple clinical outcomes, including advanced tumour stage, distant metastasis, and overall survival of PDAC patients. Yes In our cell-based assays, ectopic expression of PWAR6 dramatically repressed PDAC cells proliferation, invasion and migration, accelerated apoptosis, and induced cell cycle arrest at G0/G1 phase. In contrast, depletion of PWAR6 mediated by siRNA exhibited opposite effects on PDAC cell behaviours. In vivo study further validated the anti-tumour role of PWAR6 in PDAC. 33834618 RACGAP1P1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(miR-345-5p/RACGAP1) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray//Transwell Assay Herein, using microarray analysis, we revealed that the lncRNA RACGAP1P, the pseudogene of Rac GTPase activating protein 1 (RACGAP1), was up-regulated in breast cancer tissues. In conclusion, lncRNA RACGAP1P promotes breast cancer invasion and metastasis via miR-345-5p/RACGAP1 pathway-mediated mitochondrial fission. Subsequently, we found that RACGAP1P expression was positively correlated with lymph node metastasis, distant metastasis, TNM stage, and shorter survival time in 102 breast cancer patients. Yes Overexpression of RACGAP1P in MDA-MB-231 and MCF7 breast cell lines increased their invasive ability and enhanced their mitochondrial fission. Conversely, inhibition of mitochondrial fission by Mdivi-1 could reduce the invasive ability of RACGAP1P-overexpressing cell lines. 33252198 PVT1-214 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Regulation[PVT1-214/Lin28/let-7 axis ] RNA Pull-Down//ISH//qRT-PCR//RIP//Luciferase Report Assay//Microarray//IHC In particular, we found that the 14 PVT1 transcripts were remarkably increased in CRC tissues (Supplementary Table S2). To validate our microarray findings, 11 transcripts with sequence lengths more than 500 nt were analyzed by qRT-PCR in 6 pairs of CRC tissues and corresponding non-tumor tissues from cohort 1 (Supplementary Figure S2a). qRT-PCR analysis confirmed the microarray findings, demonstrating that the 11 PVT1 transcripts were differentially upregulated in CRC. Furthermore, using RNA pull-down and mass spectrometry, we found that Lin28 (also known as Lin28A), a highly conserved RNA-binding protein, is associated with PVT1-214. Strikingly, we found that PVT1-214 not only upregulated Lin28 protein expression in CRC cells by stabilizing Lin28, but also participated in crosstalk with Lin28 mRNA through competition for miR-128 binding, imposing an additional level of post-transcriptional regulation. In addition, we further show that PVT1-214 repressed expression of let-7 family miRNAs, which was abrogated by Lin28 knockdown. Taken together, our findings support a model in which the PVT1-214/Lin28/let-7 axis serves as a critical regulator of CRC pathogenesis, which may simulate a new direction for CRC therapeutic development. Yes In vitro and in vivo investigation of the role of PVT1-214 revealed a complex integrated phenotype affecting cell growth, stem-like properties, migration, and invasion. 30076414 PVT1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] ISH//Western Blot We found that PVT1 and c-myc were highly expressed in both Han and Uygur GC tissues. In Han GC, PVT1 was correlated with lymph node metastasis and primary tumor site. In Uygur GC, both PVT1 and c-myc were correlated with lymph node metastasis and clinical staging. Yes When PVT1 expression was silenced, the expression of c-myc decreased, while migration and invasion ability were also decreased in cells. 30679629 PVT1 CircRNA Homo sapiens Stomach Neoplasms GC cells Interaction(miR-423-5p/Smad3 pathway) Western Blot//CCK8//qRT-PCR//IF//Luciferase Report Assay//Invasion Assay//Transwell Assay CircPVT1 displayed higher expression in GC cells and knockdown led to decrease in cell growth, invasion and migration. CircPVT1 was targeted by miR-423-5p as a ceRNA of SMAD3. miR-423-5p upregulation suppressed both cicRNA PVT1 and SMAD3 in GC cells. Decrease in SMAD3 expression suppressed CircPVT1 by releasing miR-423-5p in cells, inhibiting cell growth, invasion and migration and suppressing the EMT process. Yes CircPVT1 displayed higher expression in GC cells and knockdown led to decrease in cell growth, invasion and migration. 35663842 PVT1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and tissues Regulation(STAT3/VEGFA signalling axis) CCK8//qRT-PCR//Migration Assay//Western Blot Here we demonstrated that lncRNA PVT1 was upregulated and significantly associated with high-microvessel density and poor prognosis in gastric cancer. Collectively, our study first elucidates the mechanism of PVT1-mediated angiogenesis via evoking the STAT3/VEGFA signalling axis, which provides promising target for developing new therapeutic strategy in gastric cancer. Here we demonstrated that lncRNA PVT1 was upregulated and significantly associated with high-microvessel density and poor prognosis in gastric cancer. Yes Through gain- and loss-of PVT1 expression, we found PVT1 could obviously induce angiogenesis within tumors, in addition to promoting tumor growth in vitro and in vivo. 29706652 PVT1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines interaction[Sponging miR-543] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay PVT1 expression was upregulated in breast cancer tissues and cell lines.Mechanically, the overexpression of PVT1 enhanced TRPS1 level by negatively targeted miR-543 in breast cancer. Yes In addition, PVT1 silencing inhibited breast cancer cell growth and motility, while increased apoptosis. 32982402 PVT1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction(miR-148a-3p/ROCK1 Axis) Western Blot//RIP//qRT-PCR//Luciferase Report Assay//Transwell Assay Upregulation of PVT1 and ROCK1, and downregulation of miR-148a-3p were observed in BC tissues and cell lines. According to the analysis of Dual Luciferase activity, RIP and Spearman correlation analysis, miR-148a-3p directly binds to PVT1, and ROCK1 is a target of miR-148a-3p. Yes In addition, PVT1 regulated the cells migration and invasion by regulating miR-148a-3p and ROCK1 expression. 34859371 PVT1 LncRNA Homo sapiens Breast Neoplasms breast cancer patients' plasma and cell lines Interaction(miR-128-3p and UPF1) In Vivo Experiment//Western Blot//Wound Healing Assay//RIP//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay PVT1 is significant upregulated in breast cancer patients' plasma and cell lines. Mechanistically, PVT1 upregulates FOXQ1 via miR-128-3p and promotes epithelial-mesenchymal transition. In addition, PVT1 binds to the UPF1 protein, thereby inducing epithelial-mesenchymal transition, proliferation and metastasis in breast cancer cells. Yes PVT1 promotes breast cancer cell proliferation and metastasis both in vitro and in vivo. 34922601 PVT1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines (H1299, H1650, A549, PC9, and SK-MES-1) Interaction[miR-497 ] qRT-PCR//MTT//Luciferase Report Assay//Western Blot We firstly found that circPVT1 was overexpressed in clinical NSCLC tissues and cell lines. NSCLC patients with high expression of circPVT1 exhibited aggressive clinicopathological characteristics and poor prognosis. We further found that circPVT1 served as a competing endogenous RNA of miR-497 and indirectly regulated Bcl-2 expression in NSCLC cells. Finally, inhibition of miR-497 abrogated the effects of circPVT1 knockExpression[down-expression] in NSCLC cells. Yes In vitro assays of the NSCLC cell lines (H1299 and A549 cells) demonstrated that knockExpression[down-expression] of circPVT1 inhibited NSCLC cell proliferation and induced NSCLC cell apoptosis. 30590312 RAB11FIP1P1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[lower expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 PVT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[PVT1/miR-145-5p/ITGB8 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay We found out that the expression levels of PVT1 and ITGB8 were upregulated in NSCLC tissues and cells. In conclusion, the knockdown of PVT1 inhibited proliferation, migration, and invasion but induced apoptosis of NSCLC cells by regulating miR-145-5p/ITGB8 axis and inhibiting MEK/ERK signaling pathway, providing a novel avenue for the treatment of NSCLC. Yes Knockdown of PVT1 or ITGB8 suppressed cell proliferation, migration, invasion and promoted apoptosis in NSCLC cells, which could be reversed by ITGB8 overexpression in NSCLC cells. 32202906 RBM5-AS1 LncRNA Homo sapiens Osteosarcoma Os tissues and cell lines Expression(highly expressed) qRT-PCR//Western Blot LncRNA RBM5-AS1 was overexpressed in the Os tissues and cell lines. Yes And lncRNA RBM5-AS1 promoted Os cell proliferation, migration, and invasion in vitro and tumor growth in vivo. LncRNA RBM5-AS1 targets RBM5 in Os cells. 33816613 RCC2-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines regulation[RBBP4 ,MFAP2 ] qRT-PCR In this study, we found that LCPAT1 was highly expressed in BC tissues and cell lines.In sum, LCPAT1 promotes BC progression through recruiting RBBP4 to initiate MFAP2 transcription. High LCPAT1 expression predicted a low survival rate in BC patients. Yes LCPAT1 promoted BC cell proliferation, migration, and invasion while inhibiting apoptosis in vitro.LCPAT1 knockdown suppressed BC growth in vivo and vice versa. 32791452 RCAT1 LncRNA Homo sapiens Carcinoma, Renal Cell renal cell carcinoma tissues and cells Interaction(miR-214-5p/E2F2 axis ) CCK8//qRT-PCR//Luciferase Report Assay Our data further revealed that the expression of lncRNA RCAT1 was significantly upregulated in renal cell carcinoma tissues and cells. Taken together, our findings suggested that lncRNA RCAT1 could enhance the malignant phenotype of renal cell carcinoma cells by modulating miR-214-5p/E2F2 axis, and lncRNA RCAT1 might be a novel prognostic biomarker and a potential therapeutic target for renal cell. Yes Gain-of-function and loss-of-function studies showed that lncRNA RCAT1 promoted cell proliferation, migration, and invasion in vitro and in vivo. 34244473 RC3H2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck regulation[MicroRNA-101-3p/EZH2 Axis] RNA Pull-Down//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay Taken together, our findings demonstrate that RC3H2 as completive endogenous RNA sponging miR-101-3p targets EZH2 and facilitates OSCC cells' malignant behavior. Yes Silencing of RC3H2 inhibited OSCC cell proliferation, colony formation, migration, and invasion in vitro and reduced the expression of EZH2 and H3K27Me3, whereas RC3H2 overexpression significantly promoted OSCC cell growth, colony formation, migration, invasion, and xenograft tumor growth in vivo and increased the expression of EZH2 and H3K27Me3. 32163895 RBPMS CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Interaction(miR-330-3p/RAI2 ) qRT-PCR//FISH Expression profile analysis of circular RNAs (circRNAs) in BC revealed that circRBPMS was significantly downregulated. Low circRBPMS expression correlates with aggressive BC phenotypes, whereas upregulation of circRBPMS suppresses BC cell proliferation and metastasis by directly targeting the miR-330-3p/ retinoic acid induced 2 (RAI2) axis. Yes miR-330-3p upregulation or silencing of RAI2 restored BC cell proliferation, invasion, and migration following overexpression of circRBPMS. RAI2 silencing reversed miR-330-3p-induced cell invasion and migration as well as growth inhibition in vitro. 33614236 RBMS3-AS3 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues and cells Regulation[ RBMS3-AS3/miR-4534/VASH1 axis] qRT-PCR//Microarray The obtained results indicated that RBMS3-AS3 was poorly expressed in prostate cancer tissues and cells.Taken together, the present study provides evidence suggesting that RBMS3-AS3 acts as a miR-4534 sponge to inhibit the development of prostate cancer by upregulating VASH1, highlighting a theoretical target for prostate cancer treatment. Yes Of note, overexpression of RBMS3-AS3 was found to suppress cell proliferation, migration, invasion, and angiogenesis as well as the tumorigenic ability of prostate cancer. 31712637 RBMS1 CircRNA Homo sapiens Myocardial Reperfusion Injury H9c2 cell, AMI patient Interaction(miR-92a/BCL2L11 signaling pathway) RNA Pull-Down//TUNEL//Western Blot//Transfection//qPCR//Tunel//Flow Cytometry//PCR//IHC//IF circRbms1 is overexpressed in AMI.circRbms1 targeted miR-92a, the downregulation of which alleviated the effects of circRbms1 knockdown and increased oxidative stress and H9c2 cell apoptosis. Moreover, circRbms1 sponged miR-92a to upregulate BCL2L11, which modulated the expression of apoptosis-related genes. circRbms1 participated in myocardial I/R injury by regulating the miR-92a/BCL2L11 signaling pathway, which may provide a new strategy for the treatment of AMI. Yes However, circRbms1 knockdown alleviated H9c2 cell apoptosis and reduced the release of reactive oxygen species.circRbms1 targeted miR-92a, the downregulation of which alleviated the effects of circRbms1 knockdown and increased oxidative stress and H9c2 cell apoptosis. 35068339 RBM5-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-132/212 ) Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay RBM5-AS1 is highly expressed in HCC tissues and cell lines, especially in Hep3B and HepG2 cells. Importantly, RBM5-AS1 acts as an epigenetic regulator to elevate the H3K27me3 level of miR-132/212 promoter regions via recruiting PRC2 (EZH2, SUZ12, EED), and eventually reducing miR-132/212 expressions. The recovery experiments demonstrated that downregulation of miR-132/212 markedly eliminate the antitumor effects mediated by RBM5-AS1 silencing in HCC cells. Yes RBM5-AS1 knockdown dramatically restrains cell proliferation, invasion and migration of HCC cells. 34019714 RBM5-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck tumor tissues and their matched adjacent normal tissues, cell lines(Tca8113, SCC9, SCC25, CAL27, HN12, HSU3, FADU,NHOK) Interaction[p53;YAP1] qRT-PCR//Western Blot//Luciferase Report Assay//ChIP RBM5-AS1 was dramatically Expression[Expression[up-expression]-expression]regulated in OSCC than in the normal tissues (Fig. 1A). We then analyzed the expression of RMB5-AS1 in OSCC cell lines, including Tca8113, SCC9, SCC25, CAL27, HN12, HSU3, FADU, and normal human oral keratinocytes NHOK cell. The results showed that RBM5-AS1 was Expression[Expression[up-expression]-expression]regulated in OSCC comparing to NHOK cells.We also found that RBM5-AS1 regulates the level of miR-1285-3p as a competitive endogenous RNA (ceRNA), therefore regulate the expression level of an oncogene-YAP1, a target of miR-1285-3p. Subsequently, we used the chi-square test to determine RBM5-AS1 expression and clinicopathological characteristics correlation in OSCC patients. RBM5-AS1 was closely related to the tumor size, differentiation, TNM stage, and lymph node metastasis, but not to the patient's age, sex, and tumor location (Table 1). Yes KnockExpression[down-expression] of RBM5-AS1 significantly inhibited cell proliferation compared to the negative control groExpression[Expression[up-expression]-expression] in both cell lines (Fig. 3, A and B). Our results from colony forming assay with Tca8113 and SCC9 cells after siRNA transfection also showed that si-RBM5-AS1#1 and si-RBM5-AS1#2 effectively inhibited colony formation (Fig. 3, C and D). 31869662 RBM33 CircRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(miR-758-3p/PUM2 axis) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Proliferation Assay//IF//PCR//Cell Proliferation Assay//Transwell Assay CircRBM33 and PUM2 were upregulated while miR-758-3p was downregulated in CC tissues and cells. Mechanistically, circRBM33 sponged miR-758-3p to modulate PUM2 expression. MiR-758-3p inhibitor neutralized circRBM33 silencing-mediated effects on the malignant behaviors of CC cells. PUM2 elevation overturned the suppressive influence of miR-758-3p upregulation on the malignant behaviors of CC cells. Yes Functionally, circRBM33 knockdown constrained tumor growth in vivo and cured CC cell proliferation, migration, invasion, glycolysis, and fostered CC cell apoptosis in in vitro. 33398465 RAD1-AS460 LncRNA Homo sapiens Colorectal Neoplasms cell line interaction[RAD51-AS1/miR-29b/c-3p/NDRG2 interaction network ] qRT-PCR Consistently, RAD51-AS1 expression was observed to be lower in CRC cell lines compared with normal cell line (NCM460).Collectively, these findings provide comprehensive evidence that RAD51-AS1 repressed cell proliferation, migration, invasion and glycolysis process, ultimately contributing to the progression of CRC by repressing the miR-29b/c-3p/NDRG2 signaling axis, insinuating the putative potential of RAD51-AS1/miR-29b/c-3p/NDRG2 interaction network in unraveling CRC pathology and hopefully contributed to the treatment of CRC patients. Yes Functionally, administration of RAD51-AS1 refrained growth, invasion and migration of CRC cells. 33314669 RBM33 CircRNA Homo sapiens Aortic Aneurysm, Abdominal AAA tissues and Ang II-induced VSMCs Interaction(miR-4268/EPHB2 axis ) qPCR//Western Blot//PCR//IF Moreover, circRBM33 was significantly increased in AAA tissues and Ang II-induced VSMCs compared with control samples. Mechanistically, miR-4268 targeted binding to circRBM33 and inhibited the luciferase activity of circRBM33. Overexpression of circRBM33 induced the expression of EPH receptor B2 (EPHB2), and this effect was countered by miR-4268 mimics. Yes Overexpression of circRBM33 increased the expression of ECM-related molecule matrix metalloproteinase-2 and reduced the tissue inhibitor of matrix metalloproteinases-1 expression. 34820156 RASSF8-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma 140 ESCC patients and 140 healthy controls Regulation CCK8//qRT-PCR The in vitro assays showed that RASSF8-AS1 played an oncogenic role in ESCC. Target mRNA scanning results suggested involvement of RASSF8-AS1 in tumor immunity and metabolism. Yes The in vitro assays showed that RASSF8-AS1 played an oncogenic role in ESCC. Target mRNA scanning results suggested involvement of RASSF8-AS1 in tumor immunity and metabolism. 36266257 RASSF8-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC cells and tissues Interaction(miR-33a-5p/HNRNPC/RASSF8 axis ) qRT-PCR//Wound Healing Assay//Transwell Assay The expression of RASSF8-AS1 and RASSF8 was positively correlated in CRC, and the two genes were down-regulated in CRC cells and tissues. As for the downstream mechanism, RASSF8-AS1 sponged miR-33a-5p to up-regulate RASSF8, or recruited HNRNPC to stabilize RASSF8 mRNA. Yes Moreover, CRC cell invasion and migration as well as xenograft CRC tumor growth suppressed by RASSF8-AS1 overexpression were entirely recovered by RASSF8 knockdown or partially rescued by miR-33a-5p augment. 35839610 RASSF8-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC cell lines and carcinoma tissues regulation[miR-664b-3p/TLE1 axis] qRT-PCR//RIP//Transwell Assay The RASSF8?AS1 mRNA expression level was decreased in LSCC cell lines and carcinoma tissues, while overexpression of RASSF8?AS1 reduced the migration, invasion and proliferation abilities of LSCC cells. In conclusion, the RASSF8‑AS1/miR‑664b‑3p/TLE1 axis acts by suppressing LSCC progression and may provide a novel insight for the molecular mechanism of LSCC. Yes The RASSF8?AS1 mRNA expression level was decreased in LSCC cell lines and carcinoma tissues, while overexpression of RASSF8?AS1 reduced the migration, invasion and proliferation abilities of LSCC cells. 33000257 RANGAP1 CircRNA Homo sapiens Osteosarcoma tumor tissues and cells Interaction(miR-542-3p/MYLIP) RNA Pull-Down//Western Blot//Transfection//qPCR//Flow Cytometry//RIP//IF//PCR//IP//Transwell Assay circ-RANGAP1 expression was elevated in tumor tissues from OS patients, which was correlated to the poor clinicopathology. circ-RANGAP1 expression was augmented in males or patients younger than 20 years old or patients with advanced OS. After silencing circ-RANGAP1 or elevating miR-542-3p in MG63 cells, cell progression was limited. miR-542-3p downregulation reduced the therapeutic efficacy of silenced circ-RANGAP1. circ-RANGAP1 bound with miR-542-3p to target MYLIP. circ-RANGAP1 expression was elevated in tumor tissues from OS patients, which was correlated to the poor clinicopathology. Higher circ-RANGAP1 expression indicated a poor prognosis in OS patients. Yes After silencing circ-RANGAP1 or elevating miR-542-3p in MG63 cells, cell progression was limited. miR-542-3p downregulation reduced the therapeutic efficacy of silenced circ-RANGAP1. circ-RANGAP1 bound with miR-542-3p to target MYLIP. 35747400 RAMS11 LncRNA Homo sapiens Colorectal Neoplasms CRC cell lines Expression(highly expressed) qRT-PCR//Western Blot//Colony Formation Assay//Migration Assay Our results revealed that higher expression of RAMS11 is associated with increased CRC proliferation, migration, and development of metastasis. Knockdown of RAMS11 induced autophagy, apoptosis along with reduction of epithelial-mesenchymal transition (EMT) suggesting that RAMS11 is involved in CRC progression. The molecular mechanisms of RAMS11 indicated that knockdown of RAMS11 significantly inhibited CRC carcinogenesis through mTOR-dependent autophagy induction. Our results revealed that higher expression of RAMS11 is associated with increased CRC proliferation, migration, and development of metastasis. Yes Knockdown of RAMS11 induced autophagy, apoptosis along with reduction of epithelial-mesenchymal transition (EMT) suggesting that RAMS11 is involved in CRC progression. The molecular mechanisms of RAMS11 indicated that knockdown of RAMS11 significantly inhibited CRC carcinogenesis through mTOR-dependent autophagy induction. 34174900 RAET1K LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction[Sponging miRNA-135a-5p] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot We found that lncRNA retinoic acid early transcript 1K (RAET1K) was upregulated in tumor tissues and were correlated with a poor prognosis of patients with LUAD;he lncRNA RAET1K/miR-135a-5p axis might participate in the regulation of LUAD progression by influencing CCNE1 expression and the accumulation of cells arrested at the G1/S phase boundary. Yes Real-time PCR and Western blot analyses showed that RAET1K overexpression and miR-135a-5p inhibition exerted a strong synergistic effect on CCNE1 expression, and cell cycle flow cytometry analysis was used to confirm the arrest of A549 and H1299 cells at the G1/S phase. 32010197 RAD51-AS1 LncRNA Homo sapiens Colorectal Neoplasms COAD specimens and CRC cells Interaction(miR-29b/c-3p/NDRG2 crosstalk) CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Herein, a survey of RAD51-AS1 expression profile in The Cancer Genome Atlas (TCGA)-colon adenocarcinoma (COAD) dataset revealed that RAD51-AS1 was downregulated in COAD specimens. Consistently, RAD51-AS1 expression was observed to be lower in CRC cell lines compared with normal cell line (NCM460). In the meanwhile, both the levels of miR-29b-3p and miR-29c-3p were prominently elevated in CRC cells. More important, RAD51-AS1 functioned as a competing endogenous RNA (ceRNA) for sponging miR-29b-3p and miR-29c-3p, leading to enhancement of their common target N-myc downstream-regulated gene 2 (NDRG2). Mechanistically, the delivery of miR-29b/c-3p mimics or ablation of NDRG2 effectively blunted the salutary effects of RAD51-AS1 on CRC cell behaviors. Yes Functionally, administration of RAD51-AS1 refrained growth, invasion and migration of CRC cells. Additionally, accumulation of RAD51-AS1 hampered glucose consumption and lactate production, as well as the restraint of hexokinase 2 (HK2) and glucose transporter 1 (GLUT1) levels. 33314669 PVT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[miRNA-526b/EZH2 regulatory loop ] CCK8//qRT-PCR//Luciferase Report Assay PVT1 was upregulated in NSCLC tissues, while miRNA-526b was downregulated. PVT1 accelerates the progression of NSCLC via targeting miRNA-526b/EZH2 regulatory loop. Worse survival was seen in NSCLC patients expressing high level of PVT1 compared to those with low level. Yes Knockdown of PVT1 attenuated viability and wound closure ability in A549 cells, which were partially reversed after miRNA-526b knockdown. 32002028 PVT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-148/RAB34 Signal Axis] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In NSCLC tissues and cells, PVT1 and RAB34 were up-regulated, and miR-148 was down-regulated. Those findings indicated that the signal pathway PVT1/miR-148/RAB34 play critical roles in the progression of NSCLC could be proposed in NSCLC as a possible diagnosis or therapeutic targets. Yes Overexpression of PVT1 was capable of promoting NSCLC cell proliferation and migration which could be reversed by miR-148 restoration or RAB34 knock down. 32184617 RFPL3S LncRNA Homo sapiens Testicular Germ Cell Tumor TGCT tissues Epigenetics(Hypermethylation ) CCK8//qRT-PCR//Transfection//Transwell Assay Compared with normal testicular tissues, the RFPL3S expression was significantly reduced in TGCT, and was significantly negatively correlated with the patient's Tumor, Node, Metastasis stage.Hypermethylation and low copy number of RFPL3S were present in TGCT, and low RFPL3S was associated with short disease-free and progression-free intervals. Compared with normal testicular tissues, the RFPL3S expression was significantly reduced in TGCT, and was significantly negatively correlated with the patient's Tumor, Node, Metastasis stage. Yes Silencing RFPL3S significantly enhanced the invasion ability and proliferation ability of TGCT cells as evaluated by Transwell and CCK-8 experiments. Additionally, RFPL3S expression was positively correlated with the infiltration of immune-activating cells such as B cells, CD8+ T cells, cytotoxic T cells, and natural killer cells, and negatively correlated with the infiltration of immunosuppressive cells such as Th17 and Th2. 35669771 PVT1 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines(HeLa, Ca Ski and SiH) Interaction[miR-16] qRT-PCR//Luciferase Report Assay//Western Blot Compared with H8 cells, LncRNA PVT1 expression levels were significantly increased in the three cervical cancer cells (Fig. 1A), and the cell numbers had also significantly increased (Fig. 1B). Yes To further identify the effect of LncRNA PVT1 on cervical cancer, HeLa, Ca Ski and SiHa cells were transfected with either the LncRNA PVT1 overexpression vector or siRNA for 60 h, and then cells were counted. Following transfection with the overexpression vector, expression of the LncRNA PVT1 was significantly increased in the three cervical cancer cells (9–12-fold changes), and the knockExpression[down-expression] efficiency of the LncRNA PVT1 siRNA was also apparent (75–90%; Fig. 1C). Increases or decreases in microRNA‑16 (miR‑16) expression (using miR mimics and inhibitors) also corresponded to changes in LncRNA PVT1 expression, in vitro. miR‑16 mimics and inhibitor had opposite effects to those of NF‑κB activity, and miR‑16 was demonstrated to directly interact with the NF‑κB gene as measured using the dual‑luciferase assay. In summary, LncRNA PVT1 inhibits the effect of miR‑16, promoting the cell cycle and inhibiting cellular apoptosis of cervical cancer cells, potentially via the NF‑κB pathway. 31322217 PVT1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder carcinoma specimens and cell lines regulation[miR-194-5p/BCLAF1 axis] Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining Our research revealed that PVT1 was significantly higher expression in bladder carcinoma specimens and cell lines. PVT1-miR-194-5p-BCLAF1 axis is involved in the malignant progression and development of bladder carcinomas. Yes Further experiments indicated that knockdown or overexpression of PVT1 restrained or promoted the malignant phenotype and WNT/β-catenin signaling in bladder cancer cells. 33188158 PVT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tumor tissues regulation[ miR-150-5p/GLUT-1] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Firstly, we found that the expression of PVT1 was increased in human OSCC tumor tissues and it was related to reduced survival of the patients.We uncovered a previously unappreciated PVT1/miR‑150‑5p/GLUT‑1 signaling axis that promotes cell proliferation, invasion, migration and inhibits apoptosis in OSCC cell lines and in vivo, which suggests that this axis could be a target for the treatment of OSCC. Firstly, we found that the expression of PVT1 was increased in human OSCC tumor tissues and it was related to reduced survival of the patients. Yes Finally, in vivo nude mouse xenograft model further verified that PVT1 knockdown inhibited tumor growth, formation, invasion and migration. 32945498 PVT1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells Expression[highly expressed] qRT-PCR LncRNA PVT1 was upregulated in osteosarcoma. Yes In vitro knockdown of lncRNA PVT1 inhibited the proliferation, migration, and invasion ability of osteosarcoma cells. 32960485 PVT1 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissue regulation[miR-526b/FOXC2] RNA Pull-Down//Western Blot//ISH//qRT-PCR//Luciferase Report Assay//Transwell Assay In the present study, we found that circular RNA PVT1 (circPVT1) was up-regulated in OS and correlated with poor prognosis of patients with OS. CircPVT1/miR-526b/FOXC2 axis might be a novel target in molecular treatment of OS. Yes Functionally, we showed that knockdown of circPVT1 suppressed OS cells metastasis. 32249539 PVT1 CircRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-24-3p/KLF8 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay CircPVT1 was over-expressed in OS tissues and cells, and correlated with clinical features of OS. CircPVT1 could bind and down-regulate miR-24-3p. MiR-24-3p overexpression inhibited the proliferation and chemoresistance of OS cells. KLF8 was over-expressed in OS cells and further up-regulated in chemoresistant cells. MiR-24-3p negatively regulated the expression of KLF8. Over-expressed circPVT1 reduced the survival of OS patients. Yes CircPVT1 inhibition suppressed the proliferation and chemoresistance of OS cells. 35171359 PVT1 LncRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues Interaction(miR-128/ ZEB1 and E-cadherin) CCK8//qRT-PCR//Transwell Assay PVT1 was overexpression in esophageal cancer tissues and high levels of PVT1 were correlated with lymphatic metastasis, high TNM stage and postoperative metastasis. The expression of ZEB1 was significantly downregulated, and the expression of E-cadherin was increased by the knockdown of PVT1. Knockdown of miR-128 restored the altered proliferation, migration and invasion and the expression of ZEB1 and E-cadherin caused by knockdown of PVT1. PVT1 was overexpression in esophageal cancer tissues and high levels of PVT1 were correlated with lymphatic metastasis, high TNM stage and postoperative metastasis. Yes Knockdown of PVT1 decreased the cell proliferation, migration and invasion abilities of esophageal cancer cell lines. 33848670 PVT1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tumor samples regulation[MiR-519d-3p and HIF-1A] RNA Pull-Down//IHC//Western Blot//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay Here, the up-regulated expression of lncRNA PVT1 is found in our PDAC tumor samples. Collectively, our findings suggested that PVT1 could act as an oncogenic lncRNA, and promote tumor progression by regulating HIF-1A via competing with miR-519d-3p. Yes Knockdown of it suppressed PDCA cells growth and glycolysis. 32201527 PVT1 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Interaction[sponging miR-140-5p] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay Results PVT1 and Smad3 were upregulated, and miR-140-5p was downregulated in cervical cancer cells.PVT1 could bind directly with miR-140-5p, and Smad3 was a downstream target of miR-140-5p. While transfection of miR-140-5p inhibitor could partially reverse the above changes in cervical cancer cells. Conclusions The results revealed that PVT1 could promote the proliferation and metastasis via increasing the Smad3 expression by sponging miR-140-5p, which might be a promising prognostic and therapeutic target for cervical cancer. Yes Inhibition of PVT1 could enhance expression of miR-140-5p, inhibit the expression of Smad3, significantly inhibited the proliferation, migration, invasion in cervical cancer cells. 31626590 PVT1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction[miR-31/ CDK1] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay LncRNA PVT1 and mRNA CDK1 had a higher expression in bladder cancer cells than that in neighboring tissues.Activity, proliferation, colony formation, migration, and invasion of bladder cancer cell were noticeably reduced by the PVT1 inhibitor than that of control group. Yes Activity, proliferation, colony formation, migration, and invasion of bladder cancer cell were noticeably reduced by the PVT1 inhibitor than that of control group. 30317572 PVT1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(miR-503/ARL2 axis) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay//Invasion Assay//Transwell Assay PVT1 and ARL2 expressions were increased, whereas miR-503 expression was decreased in CC tissues and cells. PVT1 was a sponge of miR-503, and miR-503 targeted ARL2. Yes PVT1 knockdown suppressed proliferation, migration, and invasion of CC cells, which could be largely reverted by miR-503 inhibitor. In addition, upregulated ARL2 could attenuate si-PVT1-mediated anti-proliferation and anti-metastasis effects on CC cells. Silenced PVT1 also inhibited CC tumor growth in vivo. PVT1 knockdown exerted tumor suppressor role in CC progression via the miR-503/ARL2 axis, at least in part. 33817293 PVT1 LncRNA Homo sapiens Glioma glioma cells Expression[highly expressed] Flow Cytometry//qRT-PCR//MTT LncRNA PVT1 was overexpressed in glioma cells SHG-44 RE compared with parent SHG-44 cells. Yes Down-regulation of lncRNA PVT1 inhibited the SHG-44 RE cell viability and increased glioma SHG-44 RE cells apoptosis after paclitaxel treatment, suggesting that inhibition of lncRNA PVT1 improved paclitaxel sensibility in human glioma cells. 30347597 PVT1 LncRNA Homo sapiens Glioma glioma samples (grade II–IV) and adjacent non-tumor tissues,cell lines(U-87MG、U373MG、U251、SHG44、T98G,CHG-5,HEB) Interaction[targeting miR-200a ] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay The expression of lncRNA-PVT in glioma tissues was significantly higher compared with normal tissues ,It was also demonstrated that lncRNA-PVT was upregulated in glioma cell lines compared with HEB cells.The present study reveals the overexpression of PVT1 in glioma tissue and cells and the oncogenic role of PVT1 in gliomagenesis via sponging miR-200a, thus providing a potential biomarker for the early detection of glioma and prognosis prediction. Yes In vitro, PVT1 silencing via transfection with si-PVT1 suppressed proliferation and invasion and induced G0/G1 phase arrest. 30680011 PVT1 LncRNA Homo sapiens Glioma Glioma tissues Interaction[Regulating miR-424 ] qPCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Invasion Assay Based on the negative correlation between PVT1 and miR-424, we then confirmed the direct interaction between PVT1 and miR-424 using RNA immunoprecipitation (RIP) and luciferase reporter assays. Further, we established a xenograft nude mouse model to determine the role and mechanism of PVT1 on tumor growth in vivo. In addition, PVT1 knockdown was shown to promote miR-424 in vivo. In summary, the present study demonstrated that PVT1 knockdown could negatively regulate miR-424 to inhibit human glioma cell activity, migration, and invasiveness. PVT1 knockdown could negatively regulate miR-424 to inhibit cellular activity, migration, and invasiveness in human gliomas, which explained the oncogenic mechanism of PVT1 in human gliomas. It also suggested that PVT1 might be a novel therapeutic target for human gliomas. Yes We found that PVT1 knockdown effectively inhibited cell viability, migration, and invasion of human glioma cells and increased miR-424 expression. 30832754 PVT1 LncRNA Homo sapiens Glioma glioma tissues Interaction[downregulating UPF1] qRT-PCR//RIP PVT1 was upregulated in glioma tissues relative to controls. UPF1 was conversely downregulated in glioma patients. Its level was negatively correlated to that of PVT1. The overexpression of UPF1 attenuated the proliferative and migratory abilities of U87 and LN229 cells. Both PVT1 and UPF1 were mainly enriched in the cytoplasm. The interaction between PVT1 and UPF1 was identified in the RIP assay. PVT1 prolonged the half-life of UPF1 and inhibited its synthesis. PVT1 was upregulated in glioma tissues relative to controls. Its level was higher in glioma patients with advanced stage or accompanied by metastasis. The glioma patients with a high level of PVT1 suffered a worse prognosis. Yes The overexpression of PVT1 accelerated proliferative and migratory abilities of U87 and LN229 cells. 31696483 PVT1 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[microRNA-128-1-5p,PTBP1] RNA Pull-Down//Western Blot//Wound Healing Assay//Tunel//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay PVT1 and PTBP1 expression was enhanced and miR-128-1-5p expression was degraded in glioma tissues and cells. This study suggests that down-regulated PVT1 or up-regulated miR-128-1-5p boosts apoptosis and attenuates proliferation of glioma cells by inhibiting PTBP1 expression. Yes Overexpressed miR-128-1-5p and lowly-expressed PVT1 promoted DNA damage, suppressed colony formation, invasion, proliferation and migration as well as boosted apoptosis of U251 and U87 cells. 32562719 PVT1 LncRNA Homo sapiens Glioma Glioma tissues and cells Interaction(p53 /lncRNA PVT1/ TGF-β/Smad pathway) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//EdU Staining//Transwell Assay Glioma tissues and cells showed downregulated p53 expression and increased lncRNA PVT1 expression. An adverse relationship was noted between p53 expression and lncRNA PVT1 expression. p53 was shown to be enriched in the lncRNA PVT1 promoter region and resulted in its suppression. LncRNA PVT1was found to bind to TGF-β and activate TGF-β/Smad pathway, promoting progression of glioma. Yes p53 inhibited glioma cell proliferation, migration, and invasion, and induced apoptosis as well as arrested tumor growth by downregulating lncRNA PVT1. 35275031 PVT1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues,cell lines Interaction[activating the KAT2A acetyltransferase and stabilizing HIF-1α] RNA Pull-Down//Western Blot//ISH//CCK8//qRT-PCR//RIP//RNA-seq In this study we found that the lncRNA PVT1 was upregulated in NPC, and that in patients this upregulation was associated with reduced survival.We further found that PVT1 serves as a scaffold for the chromatin modification factor KAT2A, which mediates histone 3 lysine 9 acetylation (H3K9), recruiting the nuclear receptor binding protein TIF1β to activate NF90 transcription, thereby increasing HIF-1α stability and promoting a malignant phenotype in NPC cells. Overexpression of NF90 or HIF-1α restored the proliferation in cells that had ceased proliferating due to PVT1 or KAT2A depletion. Conversely, overexpression of active KAT2A or TIF1β, but not of KAT2A acetyltransferase activity-deficient mutants or TIF1β isoforms lacking H3K9ac binding sites, promoted a PVT1-mediated increase in NF90 transcription, as well as increased HIF-1α stability and cell proliferation. PVT1 knockdown enhanced the radiosensitization effect in NPC cells via inhibiting binding between H3K9ac and TIF1β in a manner. Taken together, our results demonstrate that PVT1 serves an oncogenic role and plays an important role in radiosensitivity in malignant NPC via activating the KAT2A acetyltransferase and stabilizing HIF-1α. In this study we found that the lncRNA PVT1 was upregulated in NPC, and that in patients this upregulation was associated with reduced survival. Yes PVT1 knockdown reduced NPC cell proliferation, colony formation, and tumorigenesis in a subcutaneous mouse xenograft model systems. 31320749 PVT1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissue Interaction[inhibiting miR-128] qRT-PCR//Luciferase Report Assay Our previous studies indicated that PVT1 levels were higher in bladder cancer tissue and correlated with clinical progression and poor prognosis in bladder cancer patients. The results showed that the increased number of PVT1 transcripts interacted directly with miR-128 to decrease miR-128 binding to the VEGFC 3'-untranslated region. This effect suppressed VEGFC mRNA degradation by miR-128. In conclusion, these results indicated that PVT1 might play a critical role in bladder cancer tumorigenesis via miR-218 and VEGFC. Therefore, PVT1 could be a new biomarker for bladder cancer diagnosis and therapy. Yes Moreover, PVT1 knockdown significantly decreased the proliferation capacity of bladder cancer cells in nude mice. 30076714 PVT1 LncRNA Homo sapiens Ovarian Neoplasms SKOV3 and CAOV3 cells Regulation Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay//Transwell Assay The changes in the proliferation, migration and invasion of the cells induced by transfection with si-PVT1 were partially attenuated in the presence of rhCTGF. Furthermore, co-culture with rhCTGF reversed the si-PVT1-induced changes in the expression of EMT-associated proteins. Yes In addition, the proliferation, migration and invasion abilities of SKOV3 and CAOV3 cells were repressed following lncRNA PVT1 knockdown.The knockdown of lncRNA PVT1 also reduced the expression of CTGF and vimentin, and increased the expression of E-cadherin. 36688109 PVT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells interaction[ Sponging miR-17-5p] RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The levels of PVT1 and BAMBI were both apparently increased, and miR-17-5p was declined in NSCLC tissues and cells.These results manifested that PVT1 modulated BAMBI to promote tumor progression in NSCLC by sponging miR-17-5p. Yes The depletion of PVT1 or BAMBI blocked cell viability, migrated and invaded abilities but impelled apoptotic rate in A549 and H1299 cells. 32021261 PVT1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissue Interaction(miR-1207-5p/Wnt6/β-catenin2 pathway) RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay The lncRNA PVT1 mRNA expression in colon cancer tissue was significantly higher than that in normal adjacent tissue (p < 0.05). There was a targeting relationship between miR-1207-5p and PVT1. MiR-1207-5p had a targeted binding site with Wnt6. Yes The expression in lncRNA PVT1-silencing cells was significantly down-regulated (p < 0.05). The colonies of Caco-2-siPVT1 cells decreased, accompanied by a reduced number of cells penetrating Matrigel and migration (p < 0.05). Compared with siPVT1 + NC group, the number of colonies and migration of siPVT1 + miR-1207-5p-overexpressing group increased significantly (p < 0.05). 35763386 PVT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-551b/FGFR1 Axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//BrdU//Transwell Assay PVT1 was highly expressed in NSCLC tissues and cell lines, whereas miR-551b expression was down-regulated. MiR-551b was predicted and then confirmed as a direct downstream target of PVT1. Besides, PVT1 could increase FGFR1 expression by repressing miR-551b expression. Yes Overexpression of PVT1 potentiated viability, proliferation, migration and invasion of NSCLC cells while miR-551b inhibited the biological behaviors mentioned above. 34113122 PVT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue and cell lines Interaction( miR-497/ EZH2/Hippo/NOTCH1 signaling pathways) colony Formation Assay//RNA Pull-Down//Western Blot//Transfection//Migration Assay//RIP//migration assay//PCR//IP//Colony Formation Assay//Invasion Assay//IF These results showed that PVT1 was up-regulated in NSCLC tissue and cell lines, promoting NSCLC cell proliferation, migration and invasion.Further, we have confirmed that PVT1 regulated expression of YAP1 through EZH2-mediated miR-497 promoter methylation resulting in the inhibition of miR-497 transcription and its target YAP1 upregulation, and finally NOTCH signaling pathway was activated, which promoted EMT and invasion and metastasis. Yes Knockdown of PVT1 inhibited the expression of Yes-associated protein 1 (YAP1) and NOTCH1 signaling activation. Further, we have confirmed that PVT1 regulated expression of YAP1 through EZH2-mediated miR-497 promoter methylation resulting in the inhibition of miR-497 transcription and its target YAP1 upregulation, and finally NOTCH signaling pathway was activated, which promoted EMT and invasion and metastasis. 33650817 PVT1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell line Interaction(ALKBH5/PVT1) Western Blot//CCK8//qRT-PCR//RIP//Colony Formation Assay//Transwell Assay Mechanistic studies showed that knockdown of ALKBH5 decreased the expression and stability of PVT1 in lung cancer cells. Yes We next observed that PVT1 promoted the progression of lung cancer cells in vitro and in vivo and regulated the expression of VEGFA and angiogenesis in lung cancer.Finally, rescue experiments revealed that ALKBH5 regulated the proliferation, migration and angiogenesis of lung cancer cells, partially through PVT1. 36376862 PVT1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[CircPVT1/miR-145 axial] ISH//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay We found that circPVT1 was upregulated in CRC.Through online prediction, we found that circPVT1 had a microRNA response element (MRE) for miR-145. Additionally, we demonstrated that miR-145 was downregulated in CRC. Even further, we showed that miR-145 was involved in circPVT1 mediated facilitation of CRC metastasis. In a further mechanical study, we demonstrated that circPVT1 could target miR-145. Lastly, we revealed that the metastasis-promoting role of circPVT1 in CRC was partially achieved via miR-145 sponging. In brief, the findings of the present study illustrated that circPVT1, working as an oncogene, promotes metastasis via miR-145 sponging in CRC. CircPVT1/miR-145 axial might be a novel point in targeting treatment of CRC. Also, we illustrated that the upregulated circPVT1 was closely correlated with poor prognosis and bad clinicopathological features of patients with CRC. Yes Through a loss of function experiment, we showed that a downregulation of circPVT1 suppressed CRC cells metastasis. 30922567 PVT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[MiR-106b-5p/FJX1 Axis] qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay PVT1 was up-regulated in CRC tissues and cell lines, especially in CRC tissues with high-grade, and highly expressed PVT1 predicted worse prognosis. Knockdown of PVT1 impaired cell proliferation, migration and invasion in CRCs via regulating miR-106b-5p/FJX1 axis, which provided a novel insight into the development of therapeutic strategies for CRC patients. PVT1 was up-regulated in CRC tissues and cell lines, especially in CRC tissues with high-grade, and highly expressed PVT1 predicted worse prognosis. Yes Functional experiments demonstrated that PVT1 deletion inhibited CRC cell proliferation, migration and invasion in vitro and suppressed tumor growth in vivo. 33061574 PVT1 LncRNA Homo sapiens Colorectal Neoplasms CRC specimens Interaction(/miR-152-3p/E2F3/MAPK8 axis ) CCK8//qRT-PCR We found that PVT1 was overexpressed in CRC specimens, and its expression was higher in CRC cells than normal intestinal cells. MicroRNA-152-3p was a target of PVT1, and E2F3 was a target of miR-152-3p. Rescue experiments confirmed the interaction between miR-152-3p and PVT1 and between miR-152-3p and E2F3. Luciferase and ChIP assay results confirmed that E2F3 modulates the transcriptional activation of MAPK8. Long noncoding RNA PVT1 activated E2F3 signaling by sponging miR-152-3p. The PVT1/miR-152-3p/E2F3/MAPK8 axis promoted CRC progression. Yes Overexpression of PVT1 enhanced the proliferation, migration, and invasion of CRC cells, whereas PVT1 knockdown inhibited these processes. 34418232 PVT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(RUNX2/PVT1/miR-455 ) qRT-PCR//Luciferase Report Assay//Western Blot We found that PVT1 is up-regulated in human CRC tissues compared to adjacent normal tissues. A mechanistic study indicated PVT1 regulated the growth of CRC tumors by acting as a competing endogenous RNAs (ceRNA) and negatively regulated miR-455. Furthermore, we discovered that RUNX2, a functional transcription factor in CRC, up-regulated PVT1 expression. Therefore, our study suggested that the RUNX2/PVT1/miR-455 regulatory axis plays an important role in CRC tumorigenesis and may be a therapeutic target for the treatment of CRC. Yes We found that PVT1 is up-regulated in human CRC tissues compared to adjacent normal tissues. 29637007 PVT1 LncRNA Homo sapiens Colonic Neoplasms silico Interaction(miR-152-3p) qRT-PCR//Western Blot The in silico analysis demonstrated that PVT1 overexpression was associated with poor prognosis and increased expression of metastatic markers such as VEGFA and epidermal growth factor receptor (EGFR). Further analysis revealed that PVT1, VEGFA, and EGFR interact with and are regulated by miR-152-3p. The in silico analysis demonstrated that PVT1 overexpression was associated with poor prognosis and increased expression of metastatic markers such as VEGFA and epidermal growth factor receptor (EGFR). This finding was further validated in a small cohort of patients with colon cancer in whom increased PVT1 expression was correlated with colon cancer incidence, disease recurrence, and distant metastasis. Yes In vitro silencing of PVT1 reduced colon tumorigenic properties including migratory, invasive, colony forming, and tumorsphere generation abilities. 34336125 PVT1 CircRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC cell lines interaction[sponging microRNA-149] qRT-PCR Circ-PVT1 expression was increased in human EOC cell lines (CAOV3, SKOV3, SNU119 and OVCAR3) compared to human normal ovary surface epithelial cell line (HOSEpiC). Circ-PVT1 enhances cell proliferation but inhibits cell apoptosis through sponging miR-149 in EOC cells, which suggests that circ-PVT1 may serve as a treatment target in EOC. Yes In SKOV3 cells, cell proliferation was reduced at 48 and 72 h but cell apoptosis rate was increased at 48 h by circ-PVT1 knock-down. In CAOV3 cells, cell proliferation was increased at 48 and 72 h but cell apoptosis rate was decreased at 48 h by circ-PVT1 overexpression. 32048451 PVT1 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Interaction(miR-149-5p/FOXM1 axis) CCK8//qRT-PCR//Luciferase Report Assay In this study, we found PVT1 RNA was an ovarian specific expressing gene, and overexpressed in multiple cancer types, including ovarian cancer (OV). Our data showed miR-149-5p targeted FOXM1, which was regulated by circular PVT1. Forkhead Box M1 (FOXM1) expression in ovarian cancer exhibited high level when compared with normal tissues, and had relation with relatively poor survival. FOXM1 promoted cell viability and reduced FOXM1 could rescue circular influence of circular PVT1-caused carcinoma induction. Higher expression levels of PVT1 are related to shorter survival time in OV patients, especially in patients with advanced stage and grade. Yes Knockdown of circular PVT1 significantly suppressed OV cell proliferation, migration and invasion. Bioinformatics analysis demonstrated that circular PVT1 was involved in regulating angiogenesis, osteoblast differentiation, regulation of cell growth, type B pancreatic cell proliferation, negative regulation of apoptotic process, phospholipid homeostasis, regulation of neurogenesis, definitive hemopoiesis, cell migration, regulation of glucose metabolic process, central nervous system development and type 2 immune response.  33391456 PVT1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC patients and renal cell line 786-0 Expression(highly expressed) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay SLC16A1-AS1, PVT1, LINC0887, and LUCAT1 as up-regulated lncRNAs. Yes Moreover, we studied the effect of artificial PVT1 decrease in renal cell line 786-0 and observed an effect on cell viability and migration. 35441392 PVT1 LncRNA Homo sapiens Osteoarthritis cartilage tissues,cell lines Regulation[miR-27b-3p/TRAF3 axis ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay We found that PVT1 expression was enhanced in OA patients and IL-1β-treated C28/I2 cells. Yes Silence of PVT1 promoted cell viability and autophagy but suppressed apoptosis and inflammatory response in IL-1β-treated C28/I2 cells. 31863917 PVT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue Regulation[PVT1/miR-424-5p/INCENP axis] qRT-PCR We found that PVT1 was markedly overexpressed in HCC tissue than in normal liver tissues based on both RT-qPCR and data from TCGA, and the overexpression of PVT1 was closely related to the gender and race of the patient as well as to higher HCC tumor grades.Focusing on the new insight of the PVT1/miR-424-5p/INCENP axis, this study provides a novel perspective for HCC therapeutic strategies. Yes Additionally, the upregulation of PVT1 could promote HCC cell proliferation in vitro and vivo. 29975928 PVT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[c‑Myc promoter] qRT-PCR//RNA Pull-Down The results revealed that Expression[up-expression]regulation of PVT1 was detected in hepatitis B virus‑positive HCC tissues compared with that noted in the HBV‑negative samples.PVT1 was able to bind EZH2 and obstruct the recruitment of EZH2 to the promoter of MYC therefore promoting MYC expression by altering H3K37me3 status in Hep3B liver cancer cells, and EZH2 protein was negatively correlated with lncRNA‑PVT1 expression. In conclusion, our results indicate that lncRNA PVT1 promotes hepatitis B virus‑positive liver cancer progression by disturbing histone methylation on the MYC promoter, suggesting that lncRNA PVT1 may be a potential target for developing diagnostic and therapeutic strategies of hepatitis B virus‑positive liver cancer at the early stages. Yes ncRNA PVT1 overexpression and knockdown were achieved by transfection of an overexpression vector or shRNA. lncRNA PVT1 enhanced cell proliferation, migration, and invasion in the hepatitis B virus‑positive Hep3B cells rather than the hepatitis B virus‑negative HepG2 cells. 31894346 PVT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HepG2 cells Interaction( miR-3619-5p/MKL1 axis) qRT-PCR//ChIP//RIP//FISH Overexpression of PVT1 was positively correlated with MKL1 upregulation, which promoted HepG2 cell migration. miR-3619-5p inhibited MKL1 expression in HCC cells by acting on its 3'-UTR. Furthermore, PVT1 promoted MKL1 expression and migration in HCC cells by directly binding to miR-3619-5p. Yes Overexpression of PVT1 was positively correlated with MKL1 upregulation, which promoted HepG2 cell migration. 32156248 PVT1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues Regulation[miR-133a] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Here, we discovered that PVT1 shows higher expression in OC tissues than in normal ovarian tissues, and patients who show higher expression of PVT1 have worse progression-free and overall survivals compared to lower expression of PVT1.Mechanistically, miR-133a was identified to serve as a direct downstream target of PVT1 in OC. Here, we discovered that PVT1 shows higher expression in OC tissues than in normal ovarian tissues, and patients who show higher expression of PVT1 have worse progression-free and overall survivals compared to lower expression of PVT1. Yes Additionally, we observed that knockdown of PVT1 significantly inhibited OC cell proliferation, and decreased the migration and invasion capabilities of OC cells. 29957467 PVT1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines regulation[miR-543/SERPINI1 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay In contrast with miR-543, PVT1 and SERPINI1 were highly expressed in OC tissues and cell lines, and high levels of PVT1 were significantly associated with lower 5-year OS of patients. PVT1 can mediate the molecular mechanism of OC by miR-543/SERPINI1 axis regulatory network, which is a new therapeutic direction for OC. In contrast with miR-543, PVT1 and SERPINI1 were highly expressed in OC tissues and cell lines, and high levels of PVT1 were significantly associated with lower 5-year OS of patients. Yes Down-regulating PVT1 not only inhibited the malignant proliferation, migration and invasion of OC cells, but promoted cell apoptosis. 32441301 PVT1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Interaction(miR-148a-3p/AGO1 axis) qRT-PCR//Western Blot We reveal that PVT1 expression was significantly increased in ovarian cancer tissues which is associated with advanced FIGO stage, lymph-node metastasis, poor survival rate, and high expression of AGO1. Furthermore, we discovered that PVT1 up-regulated the expression of AGO1 and thus regulated the transforming growth factor-β (TGF-β) pathway to promote ovarian cancer progression through sponging miR-148a-3p. Additionally, the activation of ERK1/2, smad2 and smad4 is observed to be related to the PVT1/miR-148a-3p/AGO1/TGF-β pathway-induced cascades. Yes PVT1 or AGO1 knockdown significantly reduced the cell viability and increased the cell apoptosis and inhibited ovarian tumour growth and proliferation. 34288373 RFPL1S-202 LncRNA Homo sapiens Ovarian Neoplasms epithelial ovarian cancer tissues and cell lines Interaction(DDX3X/ IFN-β-STAT1 signaling pathway) qRT-PCR//ELISA//Western Blot RFPL1S-202 is significantly downregulated in epithelial ovarian cancer tissues and cell lines.Mechanistically, RFPL1S-202 could physically interact with DEAD-Box Helicase 3 X-linked (DDX3X) protein, and decrease the expression of p-STAT1 and the IFN inducible genes by increasing the m6A modification of IFNB1. RFPL1S-202 is a spliced and polyadenylated non-coding RNA with a full length of 1071 bp. Yes Gain- and loss-of-function study indicated that RFPL1S-202 could enhance cisplatin or paclitaxel in cytotoxicity, inhibit cell proliferation, invasion and migration of ovarian cancer cells in vitro, and inhibit the liver metastasis of ovarian cancer cells in vivo. 36435219 RFX3-DT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells. Interaction( miR-577/STAT3 axis) CCK8//qRT-PCR//Western Blot In contrast, miR-577, which was a downstream target of RFX3-AS1, dramatically impeded the malignant biological behaviors of NSCLC cells. STAT3 was a direct target of miR-577, and it was negatively regulated by the latter. STAT3 activation reversed miR-577-mediated anti-tumor roles. In brief, RFX3-AS1 aggravated NSCLC progression by regulating the miR-577/STAT3 axis. Yes The results manifested that overexpressing RFX3-AS1 markedly facilitated NSCLC cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT), and suppressed cell apoptosis. 35475457 PPP1R26-AS1 LncRNA Homo sapiens Breast Neoplasms breast tissues and cell lines Interaction(miR-1226-3p) Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay LncRNA PPP1R26-AS1 was highly expressed in breast tissues and cell lines. lncRNA PPP1R26-AS1 could act as ceRNA to bind with miR-1226-3p in breast cancer. This upregulation was correlated with pTNM, positive ER status, luminal B subtype, positive nodal status, and shorter overall survival in breast cancer patients. Yes Significant decreases in proliferation, migration, and invasion activity were observed upon knockdown of lncRNA PPP1R26-AS1. 35064892 RNF165 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC cells, NPC tissues Interaction(miR-214/PTEN ) BrdU//qRT-PCR//Luciferase Report Assay//Western Blot The results showed that lncAMPC was overexpressed in NPC tissues and was localized in both nuclei and cytoplasms of NPC cells. MiR-214 was positively correlated with lncAMPC. LncAMPC overexpression upregulated miR-214 and indirectly downregulated PTEN via miR-214. BrdU incorporation assay showed that lncAMPC and miR-214 overexpression increased cell proliferation. PTEN overexpression completely reversed the promoting effects of lncAMPC and miR-214 overexpression on cell proliferation. Therefore, lncAMPC might downregulate PTEN via miR-214 to increase NPC cell proliferation. Yes BrdU incorporation assay showed that lncAMPC and miR-214 overexpression increased cell proliferation. PTEN overexpression completely reversed the promoting effects of lncAMPC and miR-214 overexpression on cell proliferation. 35059924 RNF32-DT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-433-3p/CBX3 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay The expression of LINC01006 was up-regulated in HCC tissues and cells. MiR-433-3p was a target of LINC01006, and LINC01006 overexpression inhibited the viability, wound healing rate, and invasive cell number of HeP3B and SK-HeP-1 cells. In addition, CBX3 was a target of miR-433-3p, which was negatively regulated by miR-433-3p. CBX3 overexpression and miR-433-3p inhibition reversed the inhibiting effects of LINC01006 knockdown on the viability, migration, and invasion of HeP3B cells. Yes LINC01006 knockdown inhibited the viability, wound healing rate, and invasive cell number of HeP3B and SK-HeP-1 cells, and decreased the tumor volume and weight in a mouse xenograft model. 33781916 hsa_circ_103765 CircRNA Homo sapiens Crohn Disease peripheral blood mononuclear cells Interaction(miR-30 family-mediated DLL4) Western Blot//CCK8//qRT-PCR//FISH//Flow Cytometry//Luciferase Report Assay//Cell Apoptosis Assay We identify that CircRNA_103765 expression was significantly upregulated in peripheral blood mononuclear cells (PBMCs) of patients with active IBD. Yes In vitro experiments showed that TNF-α could induce the expression of circRNA_103765, which was cell apoptosis dependent, while silencing of circRNA_103765 could protect human intestinal epithelial cells (IECs) from TNF-α-induced apoptosis.  33436852 RNF32-DT LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction(miR‑28‑5p/PAK2 axis) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay The expression of LINC01006 was found to be upregulated in cervical cancer and to be associated with a poor prognosis. LINC01006 was verified as an endogenous 'sponge' that competed for microRNA‑28‑5p (miR‑28‑5p), which resulted in the upregulation of the miR‑28‑5p target P21‑activated kinase 2 (PAK2). Rescue experiments revealed that the suppression of miR‑28‑5p expression or the overexpression of PAK2 abrogated the effects of LINC01006 downregulation on malignant cellular functions in cervical cancer. The expression of LINC01006 was found to be upregulated in cervical cancer and to be associated with a poor prognosis. Yes The absence of LINC01006 inhibited the proliferation, migration and invasion of cervical cancer cells, whereas it promoted cell apoptosis in vitro. The downregulation of LINC01006 impeded tumor growth in vivo. 33576457 RNF32-DT LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines Interaction(MicroRNA 129-2-3p/CTNNB1 Axis and Activating Wnt/β-Catenin Signaling Pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay . According to the results, LINC01006 was highly expressed in LUAD tissues and cell lines. Moreover, LINC01006 enhanced CTNNB1 via sequestering miR-129-2-3p and activated the Wnt/β-catenin pathway in LUAD. Yes LINC01006 knockdown significantly suppressed cell proliferative, migratory, and epithelial-mesenchymal transition (EMT) capacities and tumor development. 33753463 hsa_circ_102610 CircRNA Homo sapiens Crohn Disease interaction[sponging of hsa-miR-130a-3p] CCK8//qRT-PCR//Luciferase Report Assay//FISH Upregulation of hsa_circRNA_102610 was determined to be positively correlated with elevated fecal calprotectin levels in CD (r = 0.359, P = 0.007) by Pearson correlation analysis.Hsa_circRNA_102610 upregulation in CD patients could promote the proliferation and EMT of intestinal epithelial cells via sponging of hsa-miR-130a-3p. Yes Hsa_circRNA_102610 promoted the proliferation of HIECs and NCM460 cells, while hsa-miR-130a-3p reversed the cell proliferation-promoting effects of hsa_circRNA_102610. 32587447 RNF185-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tumors and cells Interaction(RNF185-AS1/miR-429/LRP4 axis) qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Colony Formation Assay RNF185-AS1 was dramatically overexpressed in PTC tumors and cells. Mechanistically, RNF185-AS1 could act as a sponge of miR-429 to regulate the expression of LRP4. In addition, downregulation of miR-429 or upregulation of LRP4 could relieve the proliferation, migration, and invasion of IHH-4 and TPC-1 cells that inhibited by RNF185-AS1 knockdown. Downregulation of RNF185-AS1 may suppress PTC progression through functioning as a sponge of miR-429 to hinder the expression of LRP4. The RNF185-AS1/miR-429/LRP4 axis will lay the groundwork for future therapeutic strategies in PTC. High RNF185-AS1 expression was associated with bigger tumor size, lymph node metastasis, and advanced tumor-node-metastasis stage in PTC patients. Yes Silencing of RNF185-AS1 impeded the proliferation, migration, and invasion in vitro and constrained tumorigenesis in vivo. 35324519 RNF185-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-221-5p/integrin β5 axis] CCK8//qRT-PCR//Western Blot RNF185-AS1 was highly expressed in HCC tissues and cell lines. Our study demonstrates that RNF185-AS1 is a new oncogenic lncRNA in HCC and suggests that the RNF185-AS1/miR-221-5p/integrin β5 axis might be a potential therapeutic target for HCC. High levels of RNF185-AS1 were correlated with advanced TNM stage, distant metastasis and a poorer overall survival rate. Yes RNF185-AS1 knockdown inhibited cell proliferation, migration and invasion. 33358902 RNF13 CircRNA Homo sapiens Leukemia, Myeloid, Acute regulation[RNF13/miRNA-1224-5p Axis ] qRT-PCR//MTT//Colony Formation Assay//Transwell Assay CircRNF13 inhibited the proliferation, migration, and invasion of AML cells by regulating the expression of miRNA-1224-5p. This study provides some clues for the diagnosis and treatment of AML. Yes Furthermore, when the expression of circRNF13 was downregulated, the migration and invasion ability of AML cells was significantly reduced, and the expression of Tenascin-C related to migration and invasion also decreased significantly. 33083473 hsa_circ_0003928 CircRNA Homo sapiens Diabetic Nephropathies blood regulation[miR-151-3p/Anxa2] Western Blot//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//ELISA Hsa_circ_0003928 and Anxa2 mRNA levels were increased, whereas miR-151-3p was decreased in both HG-induced HK-2 cells and patients with DN.These results demonstrated that hsa_circ_0003928 could act as a sponge of miR-151-3p and regulate HG-induced inflammation and apoptosis partly through regulating Anxa2. Yes Hsa_circ_0003928 knockdown could decrease cell viability loss and apoptosis, increase Bcl-2 expression, and decrease Bax and cleaved caspase-3 expression. 32982348 RNF111 CircRNA Homo sapiens Stomach Neoplasms GC tissues and GC cell lines interaction[binding to miR-27b-3p] colony Formation Assay//Western Blot//Flow Cytometry//qRT-PCR//PCR//Colony Formation Assay The expression levels of the 2 genes in GC and normal samples were then compared, and it was found that the expression of circRNA RNF111 in the GC tissues was significantly higher than that in adjacent normal tissues (P<0.001; Fig. 1A). On the whole, the findings of the present study demonstrate that circR?RNF111 is involved in the regulation of growth, migration and invasion of GC cells by binding to miR?27b?3p. Yes The silencing of circR?RNF111 significantly inhibited GC cell viability, colony formation, migration and invasion, and exerted a pro?apoptotic effect. miR?27b?3p inhibitor promoted the proliferation, migration and invasion of GC cells, and inhibited cell apoptosis. 33000178 RNF10 CircRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-942-5p/GOLIM4 axis) colony Formation Assay//Western Blot//Transfection//Flow Cytometry//RIP//IF//IP//Colony Formation Assay//Transwell Assay Circ_RNF10 level was significantly reduced in BC tissues and cells.Mechanistically, circ_RNF10 acted as a ceRNA for miR-942-5p, and miR-942-5p could target GOLIM4. In addition, miR-942-5p overexpression reversed the influence of circ_RNF10 overexpression on BC progression. Furthermore, GOLIM4 silencing attenuated the inhibitory effect of miR-942-5p knockdown on BC progression. Yes Elevation of circ_RNF10 blocked BC cell proliferation, migration and invasion while promoted the apoptosis in vitro, companied with decreased PCNA and Twist1 and increased E-cadherin. Furthermore, upregulating circ_RNF10 delayed tumor growth of BC cells in nude mice. 36054164 RNA_LARP4 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines interaction[targeting FOXO3A] Wound Healing Assay//qPCR//PCR//Western Blot The circular RNA_LARP4 was lowly expressed in PCa tissues compared with adjacent samples. The low circular RNA_LARP4 expression was associated with poor prognosis of PCa patients. Yes The cell migrated and invaded ability of PCa cells was inhibited after circular RNA_LARP4 was overexpressed. 32495863 RN7SL329P LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 hsa_circ_0001206 CircRNA Homo sapiens Myocardial Infarction H9C2 cells, cardiomyocyte Interaction(miR-665/CRKL axis) RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Flow Cytometry//FISH//Luciferase Report Assay Circ_0001206 was low-expressed in H9C2 cells under H/R treatment. Circ_0001206 was formed by cyclization of CRK like proto-oncogene, adaptor protein (CRKL). It was confirmed that circ_0001206 regulated CRKL expression via acting as a competing endogenous RNA (ceRNA) of microRNA-665 (miR-665). CRKL played a protective role in MI. Yes Circ_0001206 overexpression promoted cell viability and inhibited cardiomyocyte apoptosis. 35023295 RMST LncRNA Homo sapiens Parkinson Disease PD patients and PD cell models Interaction(miR-150-5p) qRT-PCR//Luciferase Report Assay RMST was present at high levels in both serum of PD patients and PD cell models. miR-150-5p was the target gene of RMST and less expressed in the clinical serum samples and PD cell models. RMST had a certain clinical value for the diagnosis of PD with the AUC of 0.892 at a cutoff value of 1.225. Serum RMST was positively associated with the levels of TNF-α (r = 0.421, p < 0.001) and IL-1β (r = 0.567, p < 0.001) in PD patients. Yes Knockdown of RMST alleviated the apoptosis and inflammatory response of SH-SY5Y cells induced by MPP+. 34515176 RMST LncRNA Homo sapiens Adenocarcinoma of Lung LUAD samples Interaction(SOX9/FBW7) In Vivo Experiment//Western Blot//qPCR//Co-IP//CCK8//Colony Formation Assay//Transwell Assay Compared with normal tissues, RMST expression was significantly downregulated in LUAD samples. The experiments demonstrated that RMST binds directly to the SOX9 protein, resulting in the ubiquitination of SOX9 and this was mediated by F-box and WD repeat domain-containing 7 (FBW7). Clinically, RMST expression was shown to be positively correlated with the overall survival of LUAD patients. Yes This abnormal expression of RMST led to significant changes in the proliferation and migration of LUAD cells both in vitro and in vivo. 35242855 RMST LncRNA Homo sapiens Hirschsprung Disease HSCR patients Interaction(RMST/SOX2/miR-1251/AHNAK axis) Western Blot//Transfection//qRT-PCR//migration assay//Luciferase Report Assay//Microarray//Cell Proliferation Assay//ChIP As results have shown, RMST was downregulated in the aganglionic colon of HSCR patients. MiR-1251, the intronic miRNA of RMST, was also low expressed in HSCR, but RMST did not alter the expression of miR-1251 directly. Furthermore, SOX2 was found to regulate the expression of miR-1251 via binding to the promoter region of miR-1251, and RMST strengthened this function by interacting with SOX2. Moreover, AHNAK was the target gene of miR-1251, which was co-regulated by RMST and SOX2. Yes The knockdown of RMST attenuated cell proliferation and migration significantly. 35321017 hsa_circ_103124 CircRNA Homo sapiens Crohn Disease patients with CD Regulation(AKT2 Signaling Pathway) Western Blot//Flow Cytometry//FISH//CCK8//Luciferase Report Assay Here, quantitative reverse transcription PCR (RT-QPCR) results revealed that upregulated hsa_circRNA_103124 expression in patients with CD was negatively correlated with hsa-miR-650 expression but positively correlated with the white blood cell count and calprotectin levels. TSC complex subunit 1 (TSC1), one of the proteins upstream of autophagy was downregulated in patients with CD. These results indicate that hsa_circRNA_103124 upregulation in patients with CD promotes cell proliferation and inhibits autophagy by regulating the hsa-miR-650/AKT2 signaling pathway. Yes hsa-miR-650 inhibitor reversed the promotion of rapamycin-induced autophagy and the inhibition of cell proliferation by the hsa_circRNA_103124 siRNA. However, hsa-miR-650 mimics reversed the inhibition of rapamycin-induced autophagy and the promotion of cell proliferation through hsa_circRNA_103124 overexpression. 34804121 hsa_circ_0000064 CircRNA Homo sapiens Diabetic Nephropathies HRMCs Interaction(miR-424-5p/WNT2B ) Western Blot//Bioinformatics Analysis//qPCR//CCK8//Flow Cytometry//RIP//Luciferase Report Assay//ELISA//EdU Staining Circ_0000064 and WNT2B were upregulated, while miR-424-5p was downregulated in HG-treated HRMCs. MiR-424-5p was a target of circ_0000064, and miR-424-5p directly bound to WNT2B. MiR-424-5p restoration alleviated HG-induced proliferation, inflammatory responses and ECM accumulation in HRMCs, and WNT2B overexpression partially abolished the effects of miR-424-5p. Yes Circ_0000064 knockdown largely attenuated HG-induced proliferation, inflammatory responses and extracellular matrix (ECM) accumulation in HRMCs, and miR-424-5p deficiency reversed the role of circ_0000064 knockdown. 35678923 RMST LncRNA Rattus norvegicus Parkinson Disease cell nucleus and neurons Regulation(TLR/NF-κB signaling pathway) qRT-PCR//Western Blot RMST expression in brain SN of rats, TLR2, TLR4 expression in neurons and NF-κB expression in cell nucleus were increased. Moreover, reduced RMST reduced TLR2 and TLR4 expression in neurons and NF-κB expression in cell nucleus in PD rats. Yes Silenced RMST improved the neurobehavioral activities, depressed oxidative stress and neuronal apoptosis, increased TH and SYN expression, and reduced the activation degree of glial cells in SN and the inflammatory response via reducing GFAP and Iba-1. 33933526 ROR1-AS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissue regulation[DUSP5/CDKN1A] CCK8//qRT-PCR//RIP//Flow Cytometry//ChIP ROR1-AS1 level in colon cancer tissues was remarkably higher than that in normal tissues, and the expression in tumors of stage III and IV was remarkably higher than those of stage I and II. ROR1-AS1 level in colon cancer tissues was remarkably higher than that in normal tissues, and the expression in tumors of stage III and IV was remarkably higher than those of stage I and II. Meanwhile, tumors with diameters more than 5 cm had a higher ROR1-AS1 expression than those less than 5 cm. Yes After transfection with ROR1-AS1 overexpression plasmid, the cell proliferation ability was enhanced, the G0/G1 phase time of cell cycle was shortened, and the apoptosis was suppressed. 32096171 hsa_circ_001418 CircRNA Homo sapiens bladder carcinoma bladder carcinoma tissues Interaction(miR-1297) Western Blot//qPCR//Flow Cytometry//MTT//Transwell Assay The expression of circ 001418 was increased in patients with bladder carcinoma. Meanwhile, over-expression of circ 001418 induced EphA2 and cytochrome c protein expression, and suppressed FADD protein expression in vitro model of bladder carcinoma by the suppression of miR-1297. MiR-1297 reduced the pro-cancer effect of circ 001418 on apoptosis of bladder carcinoma. Yes Over-expression of circ 001418 promoted cell proliferation and transfer, and reduced apoptosis in vitro model of bladder carcinoma. Down-regulation of Circ 001418 inhibited cell proliferation and transfer, and induced apoptosis in vitro model of bladder carcinoma. 32368989 RP11-156L14.1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HSCC tissues and cell lines regulation[RP11-156L14.1/miR-548ao-3p/SSR1 axis] Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//Transwell Assay The present study explored the function of a novel lncRNA, RP11?156L14.1, in HSCC. RP11?156L14.1 was revealed to be highly expressed in HSCC tissues and cell lines. The RP11‑156L14.1/miR‑548ao‑3p/SSR1 axis could be utilized as a potential novel biomarker and therapeutic target for HSCC. Yes Knockdown of RP11?156L14.1 inhibited proliferation, migration, and invasion in HSCC cells. 33000261 RP11-147L13.8 LncRNA Homo sapiens Gallbladder Neoplasms GBC tumor samples Regulation(phosphorylation of c-Jun protein) RNA Pull-Down//Northern Blot//Western Blot//qRT-PCR//IHC The quantitative real-time PCR result indicated that lncRNA RP11-147L13.8 was found to be recurrently downregulated in GBC tumor samples. Furthermore, we found that lncRNA RP11-147L13.8 physically interacted with c-Jun protein and decreased the phosphorylation on serine-73 (c-Jun-Ser73), which might cause the enhancement of the migration, invasion, and sensitivity to gemcitabine of GBC tumor cells. Kaplan-Meier analysis revealed that decreased lncRNA RP11-147L13.8 expression level was associated with poor survival of GBC patients (p = 0.025). Yes Then, both in vitro and in vivo experiments elucidated that the overexpression of lncRNA RP11-147L13.8 suppressed the migration and invasion abilities of GBC cells and promoted the sensitivity to gemcitabine of GBC cells. 34703881 RP11-116G8.5 LncRNA Homo sapiens lung squamous cell carcinoma LUSC cell lines Interaction(miR-3150b-3p and miR-6870-5p /PHF12/FOXP4) Western Blot//Transfection//Invasion Assay//CCK8//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay RP11-116G8.5 was expressed at high level in LUSC cell lines. Furthermore, it was proven that RP11-116G8.5 could act as sponges for miR-3150b-3p and miR-6870-5p these miRNAs were found to act as cancer suppressors in LUSC cells. PHF12 and FOXP4 were verified as the target gene of miR-3150b-3p and miR-6870-5p separately. Overexpression of PHF12 and FOXP4 could reverse the repressive effect of RP11-116G8.5 knockdown on LUSC progression. Additionally, Paired Box 5 (PAX-5) was proven to be the transcription factor for RP11-116G8.5 in LUSC cells. Yes Down-regulated RP11-116G8.5 repressed cell proliferation, migration and invasion, but accelerated apoptosis. 34500373 hsa_circ_100876 CircRNA Homo sapiens bladder carcinoma BC and adjacent non‑neoplastic bladder tissues Expression [highly expressed] CCK8//qRT-PCR//Luciferase Report Assay//Microarray//IHC//Bioinformatics Analysis The results revealed upregulation of hsa_circRNA_100086, _038632, _100876, _102241, _004646, _102505, _104600, and _005411 expression in BC tissues relative to their levels in ANNB tissues, whereas hsa_circRNA_001409, _101969, and _103801 were downregulated. hsa_circRNA_100876 may increase the expression of CBX4 by competing with miR‑136‑5p, ultimately promoting the malignant biological behavior of BC. ROC curve analysis revealed an AUC value of 0.7003 (Fig. 6B), with a specificity of 52.5% and sensitivity of 90%, suggesting the potential diagnostic efficacy of hsa_circRNA_100876 as a BC biomarker. Yes Overexpression of hsa_circRNA_100876 downregulates miR-136-5p and upregulates CBX4 levels 33200221 RP11-1023L17.1 LncRNA Homo sapiens Prostatic Neoplasms Pca tissues and cells Interaction(FBXO32-mediated c-Myc ) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//Microarray//Cell Proliferation Assay Here, we identified that lncRNA RP11-1023L17.1, which is highly expressed in PCa. Microarray results revealed that RP11-1023L17.1 depletion downregulated the c-Myc transcription signature in PCa cells. RP11-1023L17.1 depletion-induced cellular phenotypes can be overcome by ectopically overexpressed c-Myc. Mechanistically, RP11-1023L17.1 represses FBXO32 mRNA expression, thereby enhancing c-Myc protein stability by blocking FBXO32-mediated c-Myc degradation. Yes RP11-1023L17.1 depletion inhibited the proliferation, migration, and cell cycle progression, and promoted the apoptosis of PCa cells, indicating that RP11-1023L17.1 acts as an oncogene in PCa cells. 36293081 RP11-1008C21.2 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] qRT-PCR//RNA-seq//FISH By RNA sequencing, the differentially expressed lncRNAs were identified (top 10 upregulated lncRNAs: PCAL7, AC083843.1, CTC-338M12.3, RP11-443B7.1, RP11-1008C21.2, RN7SL329P, RP4-773N10.4, RP11-264B17.2, KB-1507C5.2, and RP11-20B24.6; top 10 downregulated lncRNAs: RP11-77H9.2, RAB11FIP1P1, AP001625.6, CTA-217C2.1, RP11-603J24.7, RP11-315I20.1, AC092839.1, RP4-758J18.10, RP11-259O2.3, and HMGN2P17). Yes PCAL7 knockdown inhibited cell migration and proliferation. Consistently, the migration and proliferation were promoted by PCAL7 overexpression. 33219721 RP1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[suppressing p27kip1] ChIP//Western Blot//Co-IP//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//BrdU//Transwell Assay We found that RP1 was highly expressed in breast cancer and predicted poor prognosis of breast cancer patients.Taken together, our findings demonstrated that KLF5-regulated RP1 plays an oncogenic role in breast cancer by suppressing p27kip1, providing support for the clinical investigation of therapeutic approaches focusing on RP1. Yes Gain-of-function and loss-of-function assays showed that RP1 promoted the proliferation and metastasis of breast cancer cells in vitro and in vivo. 31073122 ROR1-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues regulation[miR-504] qRT-PCR//Wound Healing Assay//MTT//Luciferase Report Assay ROR1-AS1 levels were obviously upregulated in bladder cancer tissues than matched normal bladder tissues. Our data demonstrated that increased ROR1-AS1 promotes cell growth and migration of bladder cancer via regulation of miR-504, indicating ROR1-AS1 may be used as a prognostic biomarker and therapeutic target for bladder cancer. High expression of ROR1-AS1 was remarkably correlated with higher histological grade, advanced tumor stage, and positive lymph node metastasis. High ROR1-AS1 expression was markedly correlated with shorter overall survival of bladder cancer patients. Yes Moreover, knockdown of ROR1-AS1 notably repressed T24 and 5637 cell growth and migration. 31929567 hsa_circ_100876 CircRNA Homo sapiens Osteosarcoma osteosarcoma cancer tissues Interaction[microRNA-136] CCK8//qRT-PCR//Western Blot//Transwell Assay The expression of circRNA_100876 was found to be significantly Expression[Expression[up-expression]-expression]regulated in osteosarcoma, and was closely correlated with the tumor size and tumor differentiation degree. Furthermore, the level of miR-136 was negatively correlated with the expression of circRNA_100876, and miR-136 inhibitors were able to reverse the sExpression[Expression[up-expression]-expression]pression of cell proliferation induced by silencing circRNA_100876. Yes In addition, the knockExpression[down-expression] of circRNA_100876 could significantly inhibit the tumor growth, both in vitro and in vivo. 31069828 ROR1-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues regulation[miR-504] CCK8//qRT-PCR//Luciferase Report Assay We found that ROR1-AS1 was upregulated in osteosarcoma tissues compared to non-tumor samples.MiR-504 overexpression partly abrogated ROR1-AS1-induced effects on osteosarcoma cell migration and proliferation. Yes Moreover, overexpression of ROR1-AS1 induced cell migration in MG-63 cell, promoting N-cadherin and vimentin expression and inhibiting E-cadherin expression. 33401251 ROR1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines regulation[miR-670-3p] Western Blot//Wound Healing Assay//Tunel//CCK8//qRT-PCR//EdU Staining//Transwell Assay In the current study, RT-qPCR analysis uncovered that ROR1-AS1 expression was evidently upregulated in CC tissues and cell lines. These data suggested that ROR1-AS1 contributed to the malignant properties of CC cells through sponging miR-670-3p and upregulating of STC2. Yes Functional experiments (CCK-8, EdU, TUNEL, wound healing and Transwell assays as well as western blot analysis) revealed that knockdown of ROR1-AS1 markedly suppressed the malignant phenotypes of CC cells via decreasing cell viability, proliferation, migration, invasion and autography, and facilitating cell apoptosis. 33081599 ROR1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines regulation[Wnt/β-catenin/EMT signaling ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay We found that that the expressions of ROR1?AS1 were distinctly increased in CC tissues and cell lines.In addition, the distinctly decreased levels of c-myc, β-catenin, and cyclin D1 were observed in CC cells transfected with si-ROR1‑AS1. Clinical study revealed that high ROR1?AS1 expression was associated with distant metastasis, FIGO stage, and shorter five-year survival. Yes Functional assays by performing in vitro assays revealed that inhibition of ROR1?AS1 distinctly suppressed CC cell proliferation, colony formation, migration and invasion, and promoted apoptosis. 32271410 ROR1-AS1 LncRNA Homo sapiens Glioma glioma tissues regulation[Regulating miR-4686] Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay ROR1-AS1 was up-regulated in glioma tissues, and the high expression of ROR1-AS1 indicated a poor prognosis in glioma patients.Our study suggested tumor cells derived exo-ROR1-AS1 promoted glioma progression by inhibiting miR-4686, which might be a potential therapeutic target for glioma clinical treatment. ROR1-AS1 was up-regulated in glioma tissues, and the high expression of ROR1-AS1 indicated a poor prognosis in glioma patients. Yes Functional analysis showed exo-ROR1-AS1 promoted the progression of glioma cell lines SHG44 and U251. 33204092 ROR1-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LAC tissues Expression[highly expressed] Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay ROR1-AS1 expression level was significantly higher in LAC samples compared with that in adjacent tissues, which was associated with patients' prognosis. Yes Knockdown of ROR1-AS1 inhibited cell migration and cell invasion of LAC cells via suppressing epithelial-mesenchymal transition (EMT) process. 31983094 ROCR LncRNA Homo sapiens Triple Negative Breast Neoplasms cell lines Interaction[SOX9 ] Flow Cytometry//qRT-PCR//ChIP Our results imply that both linc02095 and SOX9 show elevated expression in TNBC or basal-like cell line and in patient samples. Mechanistic studies on one such nuclear-retained lncRNA, linc02095, reveal that it promotes breast cancer proliferation by facilitating the expression of oncogenic transcription factor, SOX9. Yes Knockdown of linc02095 results in decreased BC cell proliferation, whereas its overexpression promotes cells proliferation. 31690584 ROCK1 CircRNA Homo sapiens Osteosarcoma OS tissues Interaction(miR-532-5p/PTEN axis) IHC//Western Blot//ISH//Transfection//qPCR//CCK8//FISH//RIP//PCR//IP//Transwell Assay//IF We found that circROCK1-E3/E4, regulated by the well-known RNA-binding protein quaking (QKI), was downregulated in OS and correlated with unfavorable clinical features of patients with OS.Mechanistically, circROCK1-E3/E4 suppressed proliferation and migration by upregulating phosphatase and tensin homolog (PTEN) through microRNA-532-5p (miR-532-5p) sponging. We found that circROCK1-E3/E4, regulated by the well-known RNA-binding protein quaking (QKI), was downregulated in OS and correlated with unfavorable clinical features of patients with OS. Yes Functional proliferation and cell motility assays indicated that circROCK1-E3/E4 serves as a tumor suppressor in OS cells. In the constructed nude mouse model, circROCK1-E3/E4 inhibited tumor growth and lung metastasis in vivo. 35879346 circMFACR CircRNA Homo sapiens Myocardial Infarction plasma samples from both MI patients (n = 61) and healthy controls (n = 61) Interaction(miR-125b) qRT-PCR//Tunel//Cell Apoptosis Assay//Western Blot We found that MFACR was upregulated in MI and inversely correlated with miR-125b. Yes In AC16 cells, overexpression of MFACR decreased the expression levels of miR-125b and increased the methylation of miR-125b gene. Under hypoxia treatment, overexpression of MFACR increased AC16 cell apoptosis, and overexpression of miR-125b decreased cell apoptosis. 34524260 RMRP LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[miR-613/NFAT5 Axis ] qRT-PCR//Luciferase Report Assay Our data showed that the expression of RMRP in NSCLC tissues and cell lines was both up-regulated.Luciferase reporter assay confirmed that RMRP was the sponger of miR-613, and NFAT5 is the direct target of miR-613. Yes Functionally, RMRP promoted the proliferation and metastasis of A549 and H1299 cells. 32982286 RGMB-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues Interaction[sponging miR-22/NLRP3 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay In our research, lncRNA RGMB-AS1 was shown to be Expression[up-expression]regulated in LSCC tissues.In mechanism, lncRNA RGMB-AS1 could sponge miR-22 to Expression[up-expression]regulate the expression of NLRP3. Additionally, we verified that the sExpression[up-expression]pression of LSCC progression induced by lncRNA RGMB-AS1 reduction required the activity of miR-22. Altogether, these findings elucidated that lncRNA RGMB-AS1 could exert as an oncogenic factor through modulating miR-22/NLRP3 pathway, suggesting a potential novel target for the treatment of LSCC. High RGMB-AS1 expression was closely associated with advanced clinical features and poor prognosis. Yes Silencing of lncRNA RGMB-AS1 sExpression[up-expression]pressed LSCC cells proliferation and invasion in vitro and inhibited tumor growth in vivo. 31351424 RHPN1-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and cells interaction[ERK/MAPK pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay Our data showed the RHPN1-AS1 expression was significantly upregulated in both EC tissues and cells. Our study demonstrated that RHPN1-AS1 could facilitate cell proliferation, migration and invasion, as well as inhibit apoptosis via activating ERK/MAPK pathway in EC. The expression of RHPN1-AS1 was significantly correlated with FIGO stage, histological grade, and lymph node metastasis. Yes Additionally, silencing RHPN1-AS1 could inhibit proliferation, cell cycle progression, migration and invasion, and also promote apoptosis in Ishikawa and HEC-1A cells. 33169491 RHPN1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-596/IGF2BP2 Axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression level of RHPN1-AS1 in HCC samples was observed to significantly increase compared with normal tissues and its high expression was correlated with unfavorable pathological indexes.RHPN1-AS1 acts as a sponge of tumor suppressor miR-596 in HCC that can indirectly enhance the IGF2BP2 expression and function as an oncogenic lncRNA. Highly expressed RHPN1-AS1 was associated with shorter overall survival time. Yes RHPN1-AS1 overexpression remarkably accelerated proliferation and metastasis of HCC cells, while reduced apoptosis. Accordingly, RHPN1-AS1 knockdown suppressed the malignant phenotypes of HCC cells. 31692433 RHPN1-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues regulation[Inhibiting miR-1299] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay lncRNA RHPN1-AS1 was highly expressed in OC tissues. Our study demonstrates that RHPN1-AS1 promotes OC progression via sponging miR-1299, suggesting RHPN1-AS1 may be a novel therapeutic target. RHPN1-AS1 was positively correlated with OC progression and its high expression indicated a low survival rate. Yes Moreover, knockdown of RHPN1-AS1 significantly inhibited the proliferation, migration and invasion of OC cells, and bioinformatics analysis identified that miR-1299 was sponged by RHPN1-AS1 in OC cells. 32606751 RHPN1-AS1 LncRNA Homo sapiens Ovarian Neoplasms EOC tissues interaction[miR-596,LETM1] qRT-PCR//Luciferase Report Assay//RIP The expression of RHPN1-AS1 in EOC tissues was higher than that in para-cancerous control tissues. RHPN1-AS1-miR-596-LETM1 axis plays a crucial role in EOC progression. Our findings may provide promising drug targets for EOC treatment. High expression of RHPN1-AS1 was closely associated with poor prognosis in EOC patients. Yes In vitro and in vivo functional experiments showed that RHPN1-AS1 promoted EOC cell proliferation and metastasis. 32163372 RHPN1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues,cell lines Expression[highly expressed] Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay In this study, by analyzing online RNA-Seq data, we found that RHPN1-AS1 was upregulated in HNSCC tissues and that its expression level was associated with neoplasm histologic grade.High expression of RHPN1-AS1 was also confirmed in HNSCC tissues. Yes Knockdown of RHPN1-AS1 inhibited tumor cell migration, invasion and proliferation in HNSCC. Furthermore, inhibition of RHPN1-AS1 suppressed the expression of epithelial-mesenchymal transition (EMT)-related genes (β-Catenin, Claudin-1 and Vimentin) in HNSCC cells. 31417644 RHPN1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Regulation[miR-299-3p/FGF2 axis] qRT-PCR//Western Blot The results showed that RHPN1-AS1 was up-regulated in cervical cancer tissues and cell lines. In conclusion, our results revealed that RHPN1-AS1 promoted cervical cancer progression via targeting miR-299-3p/FGF2 axis. Our data suggested that RHPN1-AS1/miR-299-3p/FGF2 axis may be a promising target for cervical cancer treatment. Yes In vitro functional assays demonstrated that RHPN1-AS1 overexpression promoted SiHa cell proliferation, invasion and migration; while RHPN1-AS1 knockdown showed the opposite effects. In vivo study showed that RHPN1-AS1 knockdown suppressed tumor growth in the nude mice. 31525429 RHPN1-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction(CELF2/mTORC1 ) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RIP//Cell Apoptosis Assay//Cell Proliferation Assay//Transwell Assay In our study, RHPN1-AS1 was up-regulated in NPC tissues and cells. CELF2 was a target of RHPN1-AS1 and was down-regulated in NPC tissues and cells. CELF2 level was associated with tumor purity negatively. Low expression of CELF2 activated mTORC1 signaling pathway and increased protein expression of p-mTORC1/mTORC1 and p-P70S6K/P70S6K. RHPN1-AS1 silencing eliminated the activating effect of CELF2 silencing on mTORC1 signaling pathway. Yes RHPN1-AS1 silencing inhibited cell viability, capacity of proliferation, migration and invasion, promoted apoptosis, decreased protein expression of Bcl-2, MMP2/9, increased protein expression of Bax, caspase-3, and TIMP2 of NPC cells. 34358519 RHPN1-AS1 LncRNA Homo sapiens Prostatic Neoplasms PCa cells Interaction(miR-7-5p/EGFR/PI3K/AKT/mTOR signaling pathway) Western Blot//Flow Cytometry//FISH//qRT-PCR//CCK8//Transwell Assay//IF Overexpression miR-7-5p or silencing EGFR promoted LC3-I to LC3-II conversion, enhanced autophagy activity, induced cleaved-caspase-3 expression and apoptosis in PCa cells. Furthermore, overexpression of RHPN1-AS1 promoted phosphorylation of phosphatidylinositol 3-kinase (PI3K), AKT and mTOR, inhibited LC3-I to LC3-II conversion and reduced apoptosis in PCa cells, while GSK2126458 (an inhibitor of PI3K) reversed the effect of RHPN1-AS1 on PCa cells. Yes Subsequently, we transfected PCa cells with RHPN1-AS1 overexpression vector (RHPN1-AS1), knockdown plasmids (sh-RHPN1-AS1) and/or miR-7-5p mimics or inhibitor and/or overexpression vector (EGFR) or small interfering RNA of EGFR (si-EGFR) or its control, and found that overexpression of RHPN1-AS1 inhibited miR-7-5p expression and promoted EGFR expression, silencing RHPN1-AS1 inhibited proliferation and invasion, and induced G2/M arrest, apoptosis and autophagy in PCa cells. 3MA (an inhibitor of autophagy)-mediated autophagy inhibition attenuated RHPN1-AS1 inhibition-induced apoptosis. 36125241 RHPN1-AS1 LncRNA Homo sapiens Retinoblastoma cell lines regulation[miR-3133/JAK2] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//EdU Staining In RB cells, RHPN1-AS1 was upregulated. Furthermore, we predicted and verified that RHPN1-AS1 regulated RB progression by targeting miR-3133/JAK2. In addition, siRHPN1-AS1 also inhibited oncogene STAT3 protein expression. Yes Silencing RHPN1-AS1 inhibited the activity of RB cells and promoted apoptosis. 33426053 RHPN1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-485-5p/BSG axis ] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Our work found that lncRNA RHPN1-AS1 was observably up-regulated in HCC tissues and cell lines, especially HCCLM3 and SMMC-7721 cells. Our study opens novel insights to help understand the mechanisms of lncRNA RHPN1-AS1/miR-485-5p/BSG axis in HCC progression, which may provide a new therapeutic target for HCC treatment. Yes LncRNA RHPN1-AS1 knockdown decreased the capacity of proliferation, invasion, and migration in HCCLM3 and SMMC-7721 cells, which could be crippled by miR-485-5p inhibitor. 32435875 RHPN1-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC cell lines and tissues Interaction(miR‑485‑5p/TPX2 mRNA) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Bioinformatics Analysis Findings revealed that RHPN1-AS1 demonstrated a higher expression level in OC cell lines and tissues. It was also observed that the relationship between RHPN1‑AS1 and miR‑485‑5p was negative and that RHPN1‑AS1 could sponge miR‑485‑5p to regulate the proliferation, apoptosis, adhesion, and migration abilities of OC cells. Moreover, TPX2 was targeted by miR‑485‑5p and was significantly overexpressed in OC cell lines and tissues. Experimental investigations also revealed that TPX2 promoted the proliferation, adhesion, and migration of OC cells but suppressed the apoptosis of SKOV3 and OVCAR3 cells. Yes In addition, RHPN1?AS1 enhanced the adhesion, proliferation and migration of OC cell lines but decreased apoptosis of OC cells. 33907841 RHOT1 CircRNA Homo sapiens Breast Neoplasms breast cancer cells Interaction(mir-106a-5p/STAT3 axis) Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Significantly, our data revealed that the depletion of circRHOT1 was able to repress the proliferation and induce the apoptosis of breast cancer cells. CircRHOT1 knockdown could remarkably inhibit the invasion and migration in the breast cancer cells. Meanwhile, the depletion of circRHOT1 enhanced the erastin-induced inhibition effect on cell growth of breast cancer cells. The circRHOT1 knockdown notably increased the levels of reactive oxygen species (ROS), iron, and Fe2+ in breast cancer cells. In conclusion, we discovered that circRHOT1 contributed to malignant progression and attenuated ferroptosis in breast cancer by the miR-106a-5p/STAT3 axis. Yes Significantly, our data revealed that the depletion of circRHOT1 was able to repress the proliferation and induce the apoptosis of breast cancer cells. CircRHOT1 knockdown could remarkably inhibit the invasion and migration in the breast cancer cells. Meanwhile, the depletion of circRHOT1 enhanced the erastin-induced inhibition effect on cell growth of breast cancer cells. The circRHOT1 knockdown notably increased the levels of reactive oxygen species (ROS), iron, and Fe2+ in breast cancer cells. 33686957 RGMB-AS1 LncRNA Homo sapiens Stomach Neoplasms GC cells regulation[RGMB-AS1/miR-22-3p/NFIB axis] qRT-PCR In this study, our results demonstrated that RGMB-AS1 was upregulated in GC cells and knockdown of RGMB-AS1 suppressed cell proliferation, migration, invasion, EMT process and promoted cell apoptosis. Taken together, RGMB-AS1 contributes to the progression of GC by regulating miR-22-3p/NFIB axis, indicating a new therapeutic target for GC treatment. Yes In this study, our results demonstrated that RGMB-AS1 was upregulated in GC cells and knockdown of RGMB-AS1 suppressed cell proliferation, migration, invasion, EMT process and promoted cell apoptosis. 32064882 RGMB-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues, PTC cells Interaction(E2F1） CCK8//qRT-PCR//ChIP//Transwell Assay Results of qRT-PCR showed that the lncRNA RGMB-AS1 expression was up-regulated in 38 out of 48 cases of PTC tissues, and it was also up-regulated in PTC cells. qRT-PCR showed that after interference in E2F1, the expression of lncRNA RGMB-AS1 was down-regulated. Besides, CCK8 and transwell assays showed that proliferation, migration, and invasion capacities of PTC cells were decreased after interference in E2F1. Results of CHIP assay showed that E2F1 bound to lncRNA RGMB-AS1 promoter region. Yes Results of CCK8 assay showed that the proliferation capacity of PTC cells was decreased after interference in the expression of lncRNA RGMB-AS1, and results of transwell assay revealed that cell invasion and migration capacities were inhibited. 29687852 RGMB-AS1 LncRNA Homo sapiens Osteosarcoma OSA cell Interaction(miR-3614-5p/ANKRD1 pathway.) qRT-PCR//Western Blot FOXA1-activated RGMB-AS1 positively regulated OSA cell progression including proliferation and invasion but negatively modulated apoptosis. ANKRD1 was targeted by miR-3614-5p and was negatively interacted by miR-3614-5p. RGMB-AS1 and ANKRD1 competitively bound with miR-3614-5p. The suppression of silencing RGMB-AS1 on OSA cell progression was rescued by ANKRD1 overexpression or miR-3614-5p down-regulation. Yes FOXA1-activated RGMB-AS1 positively regulated OSA cell progression including proliferation and invasion but negatively modulated apoptosis. miR-3614-5p interacted with RGMB-AS1 and functioned as the tumor suppressor in OSA cells. 34583851 RGMB-AS1 LncRNA Homo sapiens Glioma glioma tissues Regulation[ miR-1200/HOXB2 Axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay RGMB-AS1 was upregulated in glioma tissues and associated with glioma grade and patients' prognosis. Moreover, RGMB-AS1 silencing significantly inhibited the proliferation, migration and invasion of glioma cells. RGMB-AS1 downregulation led to more tumor cells arrested in the quiescent state. Yes Moreover, RGMB-AS1 silencing significantly inhibited the proliferation, migration and invasion of glioma cells. RGMB-AS1 downregulation led to more tumor cells arrested in the quiescent state. 31819505 RGMB-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC cell line Regulation(FOXA1) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//H&E Staining//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Microarray//IHC//IF In conclusion, LncRNA RGMB-AS1 inhibits malignant behaviors and EMT by regulating FOXA1, and lncRNA RGMB-AS1 may be an important indicator of clinical prognosis. Yes In conclusion, LncRNA RGMB-AS1 inhibits malignant behaviors and EMT by regulating FOXA1, and lncRNA RGMB-AS1 may be an important indicator of clinical prognosis. 35184697 RGMB-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC cells Interaction( miR-574-3p/PIM3 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Briefly, the level of RGMB-AS1 expression in PC cells was abnormally high. RGMB-AS1 acted as a competing endogenous RNA (ceRNA) to sequester miR-574-3p and thereby regulated Pim-3 proto-oncogene, serine/threonine kinase (PIM3) expression. Conclusively, our work revealed the cancer-promoting function of RGMB-AS1 in PC and that the regulatory mechanism of the RGMB-AS1/miR-574-3p/PIM3 axis might contribute to novel biomarker development in PC treatment. Yes RGMB-AS1 knockdown impeded PC cell proliferation and migration, but induced cell apoptosis, and RGMB-AS1 overexpression led the opposite consequences. 34468207 RHPN1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell regulation[ miR-485/CDCA5 axis] qRT-PCR We found that the levels of RHPN1-AS1 were distinctly upregulated in both HCC tissues and cell lines.Further mechanistic investigation suggested that RHPN1-AS1 could promote CDCA5 expressions by functioning as a competing endogenous RNA for miR-485. Clinical investigations suggested that higher levels of RHPN1-AS1 were distinctly correlated with histologic grade, advanced tumor, node, metastasis stage, and poorer clinical prognosis. Multivariate assays identified high RHPN1-AS1 expression as an unfavorable prognostic biomarker for patients with HCC. Yes Functional study revealed that knockdown of RHPN1-AS1 was able to suppress cells proliferation and metastasis, and promote cell apoptosis. 32065447 RHPN1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue and HCC cells regulation[PI3K/AKT/mTOR pathway] Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Our findings showed that lncRNA RHPN1-AS1 was upregulated in HCC tissue and HCC cells, while miR-7-5p was downregulated. Taken together our findings demonstrated that lncRNA RHPN1-AS1 could facilitate cell proliferation, migration and invasion via targeting miR-7-5p and activating PI3K/AKT/mTOR pathway in HCC. Yes Functional experiments confirmed that silencing lncRNA RHPN1-AS1 inhibited cell proliferation, migration and invasion in HCCLM3 and MHCC97 H cells. 32910747 RMRP LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma miR-613/ neuropilin 2 (NRP2) axis Interaction(miR-613/NRP2 axis) CCK8//qRT-PCR//Western Blot RMRP was significantly upregulated in ESCC, which was associated with the lymph node metastasis status, the TNM stage of patients, and a poor outcome of ESCC patients.RMRP was involved in the progression of ESCC through regulating the miR-613/NRP2 axis, which provides a potential target for the treatment of ESCC. RMRP was significantly upregulated in ESCC, which was associated with the lymph node metastasis status, the TNM stage of patients, and a poor outcome of ESCC patients. Yes Moreover, RMRP promoted the proliferation, migration, and invasion of ESCC cells via regulating miR-613/NRP2. 34516335 circXPO1 CircRNA Homo sapiens prostate carcinoma normal tissue and cell line Interaction(MicroRNA-23a) In Vivo Experiment//Bioinformatics Analysis//Migration Assay//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//Invasion Assay In this study, the results of quantitative real-time PCR showed that circXPO1 levels were dramatically increased in human prostate cancer tissue and cell lines compared with those in normal tissue and cell line. Mechanistically, bioinformatics prediction, a dual-luciferase reporter assay, and pull-down assay suggested that circXPO1 physically targets miR-23a and negatively regulates its expression in pancreatic cancer cells. Yes Furthermore, cell proliferation, colony formation, and cell invasion assays showed that circXPO1 promoted the malignant behavior of pancreatic cells in vitro. miR-23a mimics and inhibitors effectively reversed the effects of circXPO1 on the malignant behavior of prostate cancer cells in vitro. 34386427 circNfix CircRNA Homo sapiens Myocardial Infarction cell lines Interaction[miR-214] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//ChIP Mechanistically, circNfix reinforced the interaction of Ybx1 (Y-box binding protein 1) with Nedd4l (an E3 ubiquitin ligase), and induced Ybx1 degradation through ubiquitination, repressing cyclin A2 and cyclin B1 expression. In addition, circNfix acted as a sponge for miR-214 to promote Gsk3β (glycogen synthase kinase 3 β) expression and repress β-catenin activity. Yes In vitro and in vivo, cardiomyocyte proliferation was increased by knockdown of circNfix, whereas it was inhibited by circNfix overexpression. Moreover, circNfix downregulation promoted cardiomyocyte proliferation and angiogenesis and inhibited cardiomyocyte apoptosis after myocardial infarction, attenuating cardiac dysfunction and improving the prognosis. 30947518 RMRP LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Regulation[LncRNA RMRP/miR-613 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Here, we found that RMRP expression was significantly upregulated in the HCC tissues and cells, and high RMRP expression was positively correlated with tumor aggressive phenotypes and poor overall survival of patients with HCC. In conclusion, our data demonstrated that RMRP plays an oncogenic role in regulating HCC tumorigenesis by acting as a ceRNA of miR-613, indicating RMRP/miR-613 axis may serve as a novel molecular target for the treatment of HCC. Here, we found that RMRP expression was significantly upregulated in the HCC tissues and cells, and high RMRP expression was positively correlated with tumor aggressive phenotypes and poor overall survival of patients with HCC. Yes Furthermore, RMRP knockdown suppressed cell proliferation, migration, invasion and induced cell cycle arrest at G0/G1 phase. In vivo experiment also revealed that RMRP knockdown inhibited HCC tumorigenesis, while miR-613 silencing could partly reversed the inhibitory effect of RMRP knockdown on HCC tumorigenesis. 31217855 RMRP LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[miRNA-206/TACR1 ] Western Blot//ISH//CCK8//qRT-PCR//migration assay//IHC//IF " The expression of RMRP was higher in HCC tissues than in adjacent tissues.RMRP downregulation inhibits HCC-related biological activities by the regulation of miRNA-206/TACR1." Yes Using in vitro analysis, RMRP knockdown suppressed HCC cell proliferation, invasion, and migration (P < .05). miRNA-206 overexpression had similar effects in HCC cell lines (Bel-7402 and Huh-7). 31579977 RMRP LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells interaction[Targeting microRNA-766] Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Transwell Assay RMRP was down-regulated in HCC tissues and cells.Overexpression of RMRP suppressed the tumorigenesis of HCC by targeting miR-766. Low expression of RMRP was correlated with poor survival of HCC patients. Yes The migration rate and the number of invasive cells were significantly decreased in pcDNA3.1-RMRP-transfected MHCC97H and HuH7 cells. 32308432 hsa_circ_0102485 CircRNA Homo sapiens prostate carcinoma PCa cells and tissues Interaction(miR-188-3p/ARID5B/AR axis) RIP//IP Hsa_circ_0102485 expression was decreased in PCa, and overexpression of hsa_circ_0102485 suppressed the proliferation, metastasis, invasion, and antiapoptotic abilities of PCa cells. Hsa_circ_0102485 plays an inhibitory role in PCa by regulating the Mir-188-3p/ARID5B/AR axis and may be a potential diagnostic biomarker and therapeutic target for PCa that requires further study. Yes Hsa_circ_0102485 expression was decreased in PCa, and overexpression of hsa_circ_0102485 suppressed the proliferation, metastasis, invasion, and antiapoptotic abilities of PCa cells. 35939970 RMRP LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Interaction(miR-766-5p/YAP1 axis.) RNA Pull-Down//Western Blot//Transfection//qPCR//Tunel//CCK8//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay RMRP expression was elevated in TNBC cells. Furthermore, miR-766-5p was found to bind to yes-associated protein 1 (YAP1). Moreover, miR-766-5p inhibition reversed the repressive effect of RMRP knockdown on the malignant progression of TNBC. Yes RMRP knockdown repressed cell proliferation, migration, and invasion, but induced apoptosis in TNBC. In addition, RMRP was found to target microRNA-766-5p (miR-766-5p) in TNBC cells. Silencing miR-766-5p enhanced cell viability and decreased apoptosis, whereas miR-766-5p overexpression had opposite effects. 34652079 RMRP LncRNA Homo sapiens Glioma glioma tissues Interaction(ZNRF3 axis and Wnt/β-catenin signaling) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IF he results showed that RMRP was highly expressed in glioma. In conclusion, RMRP/ZNRF3 axis and Wnt/β-catenin signaling formed a positive feedback loop to regulate TMZ resistance in glioma. The sustained activation of Wnt/β-catenin signaling by RMRP might contribute to the better management of cancers. Yes RMRP knockdown curbed cell proliferation, facilitated cell apoptosis and reduced TMZ resistance in glioma cells, and hindered the growth of TMZ-treated glioma xenograft tumors. RMRP exerted its functions by down-regulating ZNRF3 in glioma cells. 34657141 RMRP LncRNA Homo sapiens Multiple Myeloma MM tissues Interaction[sponging miR-34a-5p] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//ChIP In this paper, we proved that RMRP and c-Myc were upregulated, while miR-34a-5p was downregulated in MM cell lines and bone marrows of MM patients. Moreover, upregulation of miR-34a-5p repressed proliferation and promoted apoptosis of OPM2 and RPMI-8226 cells. However, RMRP overexpression blocked these changes triggered by miR-34a-5p mimic. Besides, RMRP knockdown repressed MM tumor growth in vivo. Conclusions, RMRP functions as a miR-34a-5p sponge to promote cell proliferation and repress cell apoptosis through upregulation of c-Myc in MM. High RMRP expression significantly correlated with worse disease-free survival and overall survival in MM patients. Yes Knockdown of RMRP inhibited proliferation and promoted apoptosis of OPM2 and RPMI-8226 cells. 30389523 RMRP LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[targeting miR-1-3p ] qRT-PCR "The results showed that RMRP was elevated in NSCLC tissues and cell lines.Collectively, our results demonstrated that the ""RMRP-miR-1-3p"" axis might promote NSCLC progression." High RMRP expression was closely associated with advanced stage for the clinical features and low overall survival in NSCLC patients. Yes Functional assay showed that loss of RMRP markedly inhibited cell proliferation, migration, and invasion. Flow cytometry assay demonstrated that the inhibition of RMRP dramatically induced cell cycle arrest in the G0/G1 phase. 31050363 RHPN1-AS1 LncRNA Homo sapiens Breast Neoplasms breast tumor samples and breast non-tumor tissues Expression[highly expressed] Western Blot//ISH//Migration Assay//qRT-PCR//Transwell Assay Consistent with our findings in the BC dataset of TCGA, RHPN1-AS1 expression was elevated in BC tissues in the ZZU TMAs (Figure 2B and ​and2C)2C) and more strongly correlated with TNM III-IV stages than with I-II stages. RHPN1-AS1 expression was upregulated in BC and elevated RHPN1-AS1 expression was strongly associated with poor prognosis of BC patients. Moreover, both univariate and multivariate analyses revealed that RHPN1-AS1 was a significant and independent predictor of BC prognosis. Yes Functionally, RHPN1-AS1 silencing attenuated BC cell proliferation, migration, and invasion in vitro, and reduced tumor growth in xenograft models. 31312362 RMRP LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cell lines Interaction[regulating microRNA-217] CCK8//qRT-PCR//Transfection//RNA-seq Results showed that expressions of ENST00000601661.1, NR_003051 and ENST00000516869.1 in CCA tissues were significantly higher than those in adjacent tissues compared to the other seven lncRNAs (Figure 1, A1‐A10). We also validated and explored the role of microRNA-217 (miR-217) with high differential expression by in vitro experiments. Yes The above results showed that inhibition of RMRP expression suppressed the characteristics of CCA cell lines. 31111617 RMRP LncRNA Homo sapiens Alzheimer Disease Human serum samples, AD transgenic (Tg) mice as well as SH-SY5Y cells Interaction(miR-3142/TRIB3 signaling axis) Western Blot//Tunel//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC//EdU Staining//IF The elevated RMRP and TRIB3 expressions and activation of autophagy were observed in AD. Interestingly, TRIB3 overexpression reversed the biological effects of RMRP silencing on Aβ1-42-induced cell apoptosis and autophagy. Further mechanistic analysis showed RMRP acted as a sponge of miR-3142 to elevate TRIB3 level. Yes Knockdown of RMRP restrained neuronal apoptosis and autophagy activation in vitro and in vivo. 35304105 RMRP LncRNA Homo sapiens Intervertebral Disc Degeneration NP tissues Regulation[miR-206 expression] qRT-PCR//MTT//Western Blot In our study, we showed that RMRP expression was up-regulated in degenerated NP tissues compared to normal NP samples, and higher RMRP expression was associated with the disc degeneration grade.These results suggested that lncRNA-RMRP promoted the progression of IDD through targeting miR-206, providing an attractive new therapeutic approach for the treatment of IDD disease. Yes Further studies indicated that ectopic expression of RMRP enhanced NP cell growth and also enhanced the expression of ki-67, PCNA and cyclin D1 in the NP cell. 30156374 RMRP LncRNA Homo sapiens Neuroblastoma neuroblastoma tissues Regulation[microRNA-206/tachykinin-1 receptor axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay RMRP was highly expressed in neuroblastoma tissues.Moreover, TACR1 was a target of miR-206 and RMRP performed as a molecular sponge of miR-206 to sequester miR-206 from TACR1 in neuroblastoma cells. TACR1 overexpression abrogated the inhibitory effect of RMRP downregulation on neuroblastoma cell progression by activating ERK1/2 pathway. Inhibition of TACR1 and ERK1/2 pathway abated RMRP-mediated pro-proliferation effect in neuroblastoma cells. RMRP knockdown hindered neuroblastoma xenograft growth by regulating miR-206/TACR1 axis via inactivating ERK1/2 pathway in vivo. Yes RMRP knockdown inhibited proliferation, migration and invasion in neuroblastoma cells. 30582709 RMRP LncRNA Homo sapiens Non-alcoholic Fatty Liver Disease NAFLD patients and rat model Interaction(miR-206/PTPN1 axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//H&E Staining//Oil Red O Staining//ELISA RMRP and PTPN1 were up-regulated, while miR-206 was down-regulated in the liver tissues of NAFLD patients and rat model.RMRP could bind to miR-206 and downregulate its expression. Meanwhile, RMRP inhibition attenuated lipid accumulation by downregulating the PTPN1-PP2ASP1-SREBP1C pathway. Furthermore, RMRP inhibited the miR-206/PTPN1-SREBP1C signaling pathway in NAFLD rats and FFA-treated AML-12 cells. RMRP inhibition prevented NAFLD progression in rats via targeting the miR-206/PTPN1 axis. Yes RMRP inhibition improved the pathological state and liver function-related indexes of liver lipid deposition in the liver tissues of NAFLD rats. RMRP inhibition alleviated steatosis and TG secretion in free fatty acids (FFA)-treated AML-12 cells. 35141790 Rmrp LncRNA Mus musculus Cerebral Ischaemia/Reperfusion Injury MCAO mice Interaction(microRNA-613/ATG3 axis and the JAK2/STAT3 pathway) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC We found significantly upregulated RMRP and ATG3, and downregulated miR-613 expressions in MCAO mice. RMRP could escalate ATG3 mRNA expression through miR-613. RMRP overexpression inhibited the activation of JAK2/STAT3 signaling pathway. We demonstrated that lncRNA RMRP competitively bound to miR-613, leading to the increase of ATG3 expression and the inhibition the JAK2/STAT3 pathway, thus promoting cerebral I/R injury in mice. Yes RMRP knockdown promoted viability and inhibited apoptosis of OGD/R-treated N2a cells, which could be reversed by miR-613 inhibition or ATG3 overexpression. 33560543 Rmrp LncRNA Mus musculus Pulmonary Fibrosis silica-induced lung fibrosis mouse model Interaction( p53/RMRP/miR122) In Vivo Experiment//ChIP//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Microarray//IF Following silica exposure, both RNA component of mitochondrial RNA processing endoribonuclease (RMRP) and p53 were significantly upregulated during the EMT.When RMRP is overexpressed, additional RMRP acts as a sponge to bind to miR122, thus decreasing miR122 levels. Yes The upregulation of p53 upon silica exposure activated RMRP expression, which promoted the EMT. he upregulation of p53 upon silica exposure activated RMRP expression, which promoted the EMT. 33297121 RHPN1-AS53 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell line( MCF-7. RHPN1-AS1) Interaction[inhibiting P53 ] qRT-PCR//FISH//Western Blot Quantitative RT-PCR revealed higher expression levels of RHPN1-AS1 in human breast cancer tissues and cell line MCF-7. In addition, luciferase reporter assay validated that RHPN1-AS1 is a molecular sponge of miR-4261, and direct transcriptional target of c-Myc. RHPN1-AS1 exerts tumorigenesis by regulating P53 expression via MDM2 gene. These findings provide insights into the role and mechanism of action of lncRNA RHPN-AS1 in breast cancer. Yes Knockdown of RHPN1-AS1 delivered by lentivirus system inhibited MCF-7 cell proliferation indicated by the cell proliferation and colony formation assays, and the knockdown of RHPN1-AS1 enhanced P53 protein expression in MCF-7 and MDA-MB-231 cells. 31089812 PVT1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells regulation[miR-515-5p/PIK3CA Axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay The levels of PVT1 and PIK3CA were upregulated in NPC tissues and cells, opposite to the expression of miR-515-5p. Downregulation of PVT1 inhibited proliferation, radioresistance and promoted apoptosis by downregulating PIK3CA via sponging miR-515-5p in NPC cells. Yes Knockdown of PVT1 inhibited cell proliferation, radioresistance and promoted cell apoptosis in NPC cells. 33116864 PVT1 LncRNA Homo sapiens Glioblastoma glioblastoma tissues Interaction(TRIM24/COPS5) In Vivo Experiment//RNA Pull-Down//Transfection//Co-IP//qRT-PCR//RIP//Colony Formation Assay PVT1 was upregulated and associated with poor prognosis in glioblastoma.Mechanistic investigations found that PVT1 interacted with TRIM24 directly and increased its protein stability. PVT1 recruited COPS5 to deubiquitinate TRIM24; reciprocally, PVT1 depletion impaired the interaction between COPS5 and TRIM24, resulting in decreased expression of TRIM24. PVT1, TRIM24, and COPS5 coordinately contributed to the activation of STAT3 signaling and malignant phenotype of glioblastoma. PVT1 was upregulated and associated with poor prognosis in glioblastoma. Yes We demonstrated that PVT1 silencing suppressed cell proliferation, colony formation, and orthotopic xenograft tumor growth. 34938610 PVT1 LncRNA Homo sapiens Atherosclerosis AS patients Regulation(MAPK/NF-κB pathway) Western Blot//Transfection//Colony Formation Assay//Flow Cytometry//qRT-PCR//MTT//ELISA//IHC//EdU Staining Consequently, PVT1 was highly expressed in AS patients. Briefly, silencing PVT1 inhibited AS development by downregulating MAPK/NF-κB pathway. Yes Silencing PVT1 decreased levels of TG, TC, LDL, IL-6, IL-1β, TNF-α, MMP-2, MMP-9, CRP, TIMP-1, MAPK, and NF-κB, increased HDL, reduced atherosclerotic plaques and macrophage content in mice, inhibited viability, clones and EdU positive rates in HA-VSMCs, but promoted apoptosis and cell cycle arrest. Inhibition of MAPK/NF-κB pathway suppressed proliferation and promoted apoptosis of HA-VSMCs while PVT1 overexpression facilitated AS development. 34775377 PSMA3-AS1 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cells Interaction(PAX5/PSMA3-AS1/miR-376a-3p/LAMC1 axis) ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Consistent with the TCGA analysis, PSMA3-AS1 was significantly overexpressed in CCA tissues and cells by RT-qPCR. Mechanistically, transcription factor PAX5 bound to the promoter region of PSMA3-AS1 and promoted its transcription. Simultaneously, PSMA3-AS1 primarily localized in the cytoplasm could competitively bind miR-376a-3p to upregulate LAMC1, thereby accelerating CCA progression. This study uncovers that PSMA3-AS1 functions as a cancer-promoting gene in CCA, and PAX5/PSMA3-AS1/miR-376a-3p/LAMC1 axis plays a vital role in CCA development. Upregulated PSMA3-AS1 was related to lymph node invasion, advanced TNM stage and poor survival, and was an independent risk factor of prognosis for CCA patients. Yes Functionally, CCK-8, EdU and colony formation assays confirmed that upregulated PSMA3-AS1 promoted CCA cell proliferation, whereas downregulated PSMA3-AS1 inhibited proliferation. This result was further confirmed by subcutaneous tumor formation in nude mice. Wound healing and transwell assays confirmed that increased PSMA3-AS1 promoted CCA cell migration and invasion, whereas decreased PSMA3-AS1 inhibited these biological phenotypes. In addition, PSMA3-AS1 promoted the EMT process of CCA by downregulating E-cadherin and upregulating N-cadherin and vimentin. 35022330 PSMB8-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC cell lines Interaction(miR-1299/ADAMTS5 ) qRT-PCR//Western Blot Based on experimental results, PSMB8-AS1 expression was notably higher in CRC cell lines than in normal cells.It was also revealed that PSMB8-AS1 could sponge miR-1299 to upregulate ADAMTS5 in CRC cells. In rescue assays, we further discovered that miR-1299 inhibition or ADAMTS5 overexpression abrogated the suppressive influence of PSMB8-AS1 deficiency on CRC cell growth. In addition, PSMB8-AS1 was validated to induce M2 polarization. Yes The downregulation of PSMB8-AS1 repressed cell viability, proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of CRC while promoting cell apoptosis. 35786996 PSMB8-AS1 LncRNA Homo sapiens Glioma glioma tissues and cells Interaction[regulating miR-574-5p/RAB10 ] Tunel//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//ChIP In our study, the expression of PSMB8-AS1 was dramatically upregulated in glioma tissues and cells, further, PSMB8-AS1 silencing restrained cell proliferation in glioma, and the results of PSMB8-AS1 overexpression were opposite. To be concluded, PSMB8-AS1 activated by ELK1 promotes cell proliferation in glioma via regulating miR-574-5p/RAB10, which may be contributory to find new targets to treat glioma. Yes In our study, the expression of PSMB8-AS1 was dramatically upregulated in glioma tissues and cells, further, PSMB8-AS1 silencing restrained cell proliferation in glioma, and the results of PSMB8-AS1 overexpression were opposite. 31812014 PSMA3-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell lines interaction[Sponging MiR-4504] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay PSMA3-AS1 expression was upregulated in lung cancer tissues and cell lines.PSMA3-AS1 promotes the tumorigenesis of lung cancer through inhibiting miR-4504. PSMA3-AS1 expression was positively correlated with clinical stage and metastasis. PSMA3-AS1 overexpression predicted a poor prognosis in lung cancer patients. Yes PSMA3-AS1 knockdown suppressed proliferation, migration and invasion of lung cancer cells. 32669876 PSMA3-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[regulating miR-4429] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay It was found that PSMA3-AS1 expression was increased and miR-4429 expression was decreased in CRC tissues and cells.PSMA3-AS1 accelerated CRC progression by regulating miR-4429 expression, which could be used as a potential therapeutic target for CRC patients. Yes In addition, PSMA3-AS1 interference markedly hindered the proliferation, migration, and invasion of CRC cells. 33275226 PSMA3-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC cells and tissues Interaction(miR-378a-3p/GALNT3 axis/PI3K/Akt pathway ) qRT-PCR//RNA Pull-Down//Luciferase Report Assay//Western Blot Reverse transcription quantitative polymerase chain reaction analysis revealed that PSMA3-AS1 expression was significantly upregulated in OC cells and tissues. Mechanistically, luciferase reporter and RNA pulldown assays implied that PSMA3-AS1 served as a competing endogenous RNA for miR-378a-3p to upregulate the expression of polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3). GALNT3 was a target gene of miR-378a-3p in OC. Moreover, PSMA3-AS1 activated the PI3K/Akt pathway by upregulating GALNT3 expression. Yes PSMA3-AS1 silencing inhibited OC cell proliferation, migration, and invasion, as shown by results of cell counting kit-8, colony formation, wound healing, and Transwell assays, respectively. Additionally, PSMA3-AS1 deficiency suppressed tumor growth in vivo. 34520102 PSMA3-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues & cells Interaction(miR-136-5p/FN1 axis) qRT-PCR//Wound Healing Assay//Transwell Assay PSMA3-AS1 upregulation was determined in OSCC tissues. The upregulation indicated pessimistic patients' outcomes. Multivariate Cox regression analyses confirmed PSMA3-AS1 as an independent prognostic indicator. Its upregulation was also found in OSCC cells. Under transfection with si-PSMA3-AS1, proliferation, migration, and invasion were all restrained in HN4 and CAL-27 OSCC cells. Furthermore, its knockdown induced the increase in E-cadherin expression and the reduction in N-cadherin and Vimentin expression. PSMA3-AS1 was a sponge of miR-136-5p. Mutual inhibition was found between two and the interactions were confirmed by dual luciferase report. It was confirmed that FN1 was a target of miR-136-5p. FN1 expression was increased by miR-136-5p inhibitors, which was lessened by si-PSMA3-AS1 cotransfection. PSMA3-AS1 upregulation was determined in OSCC tissues. The upregulation indicated pessimistic patients' outcomes. Multivariate Cox regression analyses confirmed PSMA3-AS1 as an independent prognostic indicator. Yes Furthermore, its knockdown induced the increase in E-cadherin expression and the reduction in N-cadherin and Vimentin expression. PSMA3-AS1 was a sponge of miR-136-5p. Mutual inhibition was found between two and the interactions were confirmed by dual luciferase report. 34457087 PSMA3-AS1 LncRNA Homo sapiens Esophageal Neoplasms ESCC tissues regulation[miR-101/EZH2 axis ] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay PSMA3-AS1 is significantly up-regulated in ESCC tissues, and the PSMA3-AS1/miR-101/EZH2 axis plays a critical role in ESCC progression. Forced PSMA3-AS1 expression was correlated with tumor size, distant metastasis, and poor prognosis in ESCC patients. Yes Functionally, PSMA3-AS1-overexpression promoted ESCC cells proliferation, invasion, and migration in vitro. 32005028 PSMA3-AS1 LncRNA Homo sapiens Glioma glioma cells Interaction(miR-411-3p/HOXA10 pathway) RNA Pull-Down//Transfection//Tunel//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining PSMA3-AS1 was verified to be up-regulated in glioma cells and promote glioma progression. Furthermore, PSMA3-AS1 could act as a competitive endogenous RNA (ceRNA) for miR-411-3p to regulate HOXA10 and thus affecting glioma progression. Yes Functional assays were performed to measure the effects of PSMA3-AS1 on glioma progression. 34294084 PSMA3 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cells Interaction(miR-214-5p /PD-L1) qRT-PCR//RIP The present study revealed that BC tissues and cells exhibited an increased expression in PSMA3-AS1. In conclusion, YY1-induced PSMA3-AS1 exerted an oncogenic function in BC cells via targeting miR-214-5p and enhancing PD-L1, providing potential biomarkers for BC therapy. High expression of PSMA3-AS1 was related to poor prognosis in BC patients. Then, the area under the ROC curve for PSMA3-AS1 was up to 0.8954. Yes Furthermore, it was found that that PSMA3-AS1 knockdown repressed BC cell viability and metastasis, and promoted apoptosis. 34720049 PSMG3-AS1 LncRNA Homo sapiens Glioblastoma plasma Expression[highly expressed] CCK8//qRT-PCR In this study, we found that PSMG3-AS1 was upregulated in plasma of GBM patients in comparison with that in sarcoidosis patients and healthy controls. Yes In addition, overexpression of PSMG3-AS1 reduced the inhibitory effects of miR-34a on GBM cell proliferation. 32529538 PRRG4-4 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Expression[highly expressed] qRT-PCR To explore its role in carcinogenesis, we first demonstrated that lncPRRG4-4 was upregulated in lung cancer tissues compared with adjacent nontumor tissues and functioned as an oncogene in lung cancer cells. Yes In addition, downregulation of lncPRRG4-4 expression inhibited lung cancer proliferation, viability, migration, and invasion ability, arrested cell cycle, facilitated apoptosis, and vice versa. 30362823 PRR34-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miR-296-5p/E2F2/SOX12/Wnt/β-catenin axis) qRT-PCR Here, we observed via quantitative real-time reverse transcriptase polymerase chain reaction (quantitative real-time RT-PCR) that PRR34-AS1 was highly expressed in HCC cells. Further, rescue experiments reflected that PRR34-AS1 affected HCC progression through targeting miR-296-5p/E2F2/SOX12/Wnt/β-catenin axis. Yes Functional assays revealed that PRR34-AS1 promoted HCC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) process in vitro and facilitated tumor growth in vivo. 34168917 PRR34-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(Rab27a) qRT-PCR PRR34-AS1 expression was upregulated in HCC cells in comparison to THLE-3 cells. PRR34-AS1 recruited DDX3X to stabilize the mRNA level of exosomal protein Rab27a. Moreover, PRR34-AS1 facilitated the malignant phenotypes of THLE-3 cells by elevating Rab27a expression to promote the exosome secretion of VEGF and TGF-β in HCC cells. Yes PRR34-AS1 depletion repressed HCC cell proliferation, migration and invasion as well as EMT phenotype, while PRR34-AS1 up-regulation accelerated the malignant phenotypes of THLE-3 cells. 36303180 PRR11-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation(PRR11/PI3K/AKT axis) qRT-PCR The results revealed that AC099850.3 was highly expressed in HCC tissues and cell lines, and it predicted poor prognosis in patients with HCC. The results of gene set enrichment analysis revealed that the PI3K/AKT pathway was associated with the biological function of AC099850.3, which was further validated by western blotting. PRR11 was identified as the target gene of AC099850.3 and we established that AC099850.3 acted as an oncogene in the PRR11/PI3K/AKT axis. The results revealed that AC099850.3 was highly expressed in HCC tissues and cell lines, and it predicted poor prognosis in patients with HCC. Yes Furthermore, knockdown of AC099850.3 significantly suppressed the proliferation and metastatic potential of HCC cells, and promoted cell apoptosis in HCC cells. 35154469 PRR11-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell Regulation qRT-PCR Through colony formation and CCK8 assays, we found that AC099850.3 was strongly associated with HCC cell proliferation. In addition, AC099850.3 was found to be closely associated with clinical stages and proliferation of HCC cells, making it a potential target for HCC treatment. Yes Through colony formation and CCK8 assays, we found that AC099850.3 was strongly associated with HCC cell proliferation. 35705628 PRR11-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction( hsa-miR-101-3p ) CCK8//qRT-PCR//Transfection//BrdU In this study, we found that AC099850.3 was highly expressed in LUAD and associated with an advanced tumor stage, poor prognosis, and immune infiltration. Finally, we constructed a competitive endogenous RNAs (ceRNA) network that included hsa-miR-101-3p and 4 mRNAs (ESPL1, AURKB, BUB3, and FAM83D) specific to AC099850.3 in LUAD. Kaplan-Meier survival analysis showed that a lower expression of miR-101-3p and a higher expression of ESPL1, AURKB, BUB3, and FAM83D, were associated with adverse clinical outcomes in patients with LUAD. In this study, we found that AC099850.3 was highly expressed in LUAD and associated with an advanced tumor stage, poor prognosis, and immune infiltration. Yes Functionally, the knockdown of AC099850.3 restrained LUAD cell proliferation and migration in vitro. 35646670 PRPF31 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[upregulation of Zeb1] RIP//RNA Pull-Down//Microarray RP11 was highly expressed in CRC tissues, and its expression increased with CRC stage in patients.m6A-induced lncRNA RP11 can trigger the dissemination of CRC cells via post-translational upregulation of Zeb1. Yes RP11 positively regulated the migration, invasion and epithelial mesenchymal transition (EMT) of CRC cells in vitro and enhanced liver metastasis in vivo. 30979372 PROX1-AS1 LncRNA Homo sapiens Stomach Neoplasms tissues and cell lines of GC Interaction(miR-877-5p/PD-L1 Axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay It is further disclosed that silencing of PROX1-AS1 represses cell proliferation, migration, and invasion, whereas promotes cell apoptosis in GC. Bioinformatics analysis suggests that miR-877-5p is negatively regulated by PROX1-AS1 and ectopic of miR-877-5p alleviates the malignant behaviors of GC. Subsequently, miR-877-5p suppresses the activity of PD-L1-3' UTR. At last, rescue assays demonstrated that the GC progression is suppressed by sh-PROX1-AS1 and facilitated on account of miR-877-5p inhibitors and then is retrieved by sh-PD-L1. Yes silencing of PROX1-AS1 represses cell proliferation, migration, and invasion, whereas promotes cell apoptosis in GC. 33776485 PSMG3AS1 LncRNA Homo sapiens Lung Neoplasms NSCLC tissues Interaction(miR-613 / SphK1) cell invasion assay//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay The expression of PSMG3-AS1 was upregulated in NSCLC, while the expression of miR-613 was downregulated in NSCLC. However, PSMG3-AS1 and miR-613 were not significantly correlated with each other. Interestingly, PSMG3-AS1 overexpression led to upregulated SphK1, a downstream target of miR-613. Therefore, PSMG3-AS1 may promote the proliferation of NSCLC cells by sponging miR-613 to upregulate SphK1. Yes In addition, PSMG3-AS1 overexpression reduced the inhibitory effects of miR-613 on NSCLC cell proliferation. 33849377 PSMG3-AS1 LncRNA Homo sapiens cervical squamous cell carcinoma tissue samples of 64 patients with CSCC Interaction(miR-4417) qRT-PCR//Transfection//Luciferase Report Assay//Transwell Assay The results revealed that PSMG3-AS1 expression was upregulated in CSCC tissues, and its high expression levels predicted a poor survival in patients with CSCC. miR-4417 expression was downregulated in CSCC tissues and was inversely correlated with PSMG3-AS1 expression. Moreover, miR-4417 was predicted to interact with PSMG3-AS1. The results revealed that PSMG3-AS1 expression was upregulated in CSCC tissues, and its high expression levels predicted a poor survival in patients with CSCC. Yes Transwell assay demonstrated that overexpression of PSMG3-AS1 increased CSCC cell invasion and migration.  33986863 PROX1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-326/FBXL20 axis) Western Blot//qRT-PCR//RIP//IHC//ChIP Based on TCGA and GTEx databases, we found that the expression of PROX1-AS1 was upregulated in CRC tissues and cells. Mechanistically, PROX1-AS1 was identified to act as a miR-326 sponge by luciferase reporter and RIP assay. Meanwhile, we found that the transcription factor SP1 activated PROX1-AS1/miR-32/FBXL20 axis, thereby promoting CRC progression. Bioinformatics analysis revealed that high PROX1-AS1 expression was associated with poor overall survival. Yes Functionally, PROX1-AS1 knockdown suppressed CRC cell proliferation, migration, and invasion in vitro, as well as inhibiting tumor growth in vivo. 36374774 PTAR LncRNA Homo sapiens Urinary Bladder Neoplasms BC cells and tissues Interaction(miR-299-3p/CD164 axis) qRT-PCR//Western Blot//Tunel//Transwell Assay Based on the collected data, PTAR expression was high in BC cells and silenced PTAR repressed BC cell proliferative, migratory and invasive abilities but improved cell apoptotic ability. In vivo study also verified PTAR depletion inhibited BC tumor growth. Furthermore, miR-299-3p was confirmed to bind with PTAR and its overexpression suppressed malignant behaviors of BC cells. Cluster of differentiation 164 (CD164) was proved to be miR-299-3p target. Rescue experiments implied overexpressed CD164 offset the inhibitory function of PTAR depletion on BC cell phenotype.Additionally, CD164 was uncovered to combine with C-X-C motif chemokine receptor 4 (CXCR4) to switch on PI3K/AKT pathway. To conclude, PTAR facilitates BC development via regulating miR-299-3p/CD164 axis and activating PI3K/AKT pathway. Yes Based on the collected data, PTAR expression was high in BC cells and silenced PTAR repressed BC cell proliferative, migratory and invasive abilities but improved cell apoptotic ability. In vivo study also verified PTAR depletion inhibited BC tumor growth. 35932495 PTCSC3 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction[miR-574-5p] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay Quantitative RT-PCR showed a down-regulation of PTCSC3 in cervical cancer tissues compared with normal cervical tissues. Yes Overexpression of lncRNA PTCSC3 inhibited cell proliferation, induced cell cycle arrest, and sExpression[up-expression]pressed cell invasion and migration using CCK8 assay, flow cytometry, Transwell assay and wound healing examination, respectively. 31587336 PTCSC3 LncRNA Homo sapiens Triple Negative Breast Neoplasms blood Interaction[H19] CCK8//qRT-PCR In the current study, we found that PTCSC3 was Expression[down-expression]regulated in tumor tissues of patients with TNBC. PTCSC3 expression was positively correlated with plasma levels of PTCSC3. LncRNA H19 was Expression[Expression[up-expression]-expression]regulated and was inversely correlated with PTCSC3 in tumor tissues. Yes PTCSC3 overexpression led to Expression[down-expression]regulated H19 in TNBC cells, while H19 overexpression did not affect PTCSC3 expression. 31026090 PTCSC3 LncRNA Homo sapiens Thyroid Neoplasms PTC tissues Interaction(PGK1) In Vivo Experiment//RNA Pull-Down//Western Blot//RIP//IP//Colony Formation Assay In this study, we showed that lncRNA papillary thyroid cancer susceptibility candidate 3 (PTCSC3) was significantly downregulated in papillary thyroid carcinoma (PTC).Mechanistically, PTCSC3 inhibits aerobic glycolysis and proliferation of PTC by directly interacting with PGK1, a key enzyme in glycolytic pathway. Yes Overexpression of PTCSC3 significantly inhibited the aerobic glycolysis and tumour growth of PTC cells. Consistently, PTCSC3 overexpression suppressed tumour progress in vivo. 34337858 PTCSC3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck blood Interaction[HOTAIR ] qRT-PCR In the present study, we showed that plasma PTCSC3 was down-regulated in early stage LSCC patients, and the down-regulation of PTCSC3 separated in early stage LSCC patients from control group.Therefore, PTCSC3 may negatively interact with HOTAIR through STAT3 to inhibit LSCC cell proliferation. Yes PTCSC3 overexpression mediated the inhibited, while HOTAIR overexpression mediated the promoted proliferation of LSCC cells. 31171714 PTCSC3 LncRNA Homo sapiens Mouth Neoplasms oral cancer tissues and cell lines Expression[lower expressed] qRT-PCR//Western Blot The results revealed significant (p < 0.05) suppression of PTCSC3 expression in human oral cancer tissues and cell lines. Yes PTCSC3 overexpression caused a significant (p < 0.05) decrease in invasion of the human SCC-1 and SCC-9 oral cancer cells. 33747284 PTCSC3 LncRNA Homo sapiens Osteoporosis 80 patients with osteoporosis Expression(highly expressed) qRT-PCR//Transfection//Cell Apoptosis Assay PTCSC3 was upregulated in osteoporosis patients compared with healthy controls. PTCSC3 levels increased with osteoporosis stages increasing, but not with healthy controls aging. PTCSC3 overexpression separated each stage of osteoporosis from corresponding controls. Yes PTCSC3 overexpression promoted while PTCSC3 silencing inhibited osteoblast apoptosis. However, PTCSC3 overexpression and silencing showed no significant effect on osteoclast apoptosis. 35296322 PTCSC3 LncRNA Homo sapiens oral cavity cancer human oral cancer tissues and cell lines Expression [lower expressed] cell invasion assay//Western Blot//Transfection//qRT-PCR//Cell Proliferation Assay//Transwell Assay The results revealed significant (p < 0.05) suppression of PTCSC3 expression in human oral cancer tissues and cell lines. The overexpression of PTCSC3 caused a significant (p < 0.05) decline in the proliferation of the human oral cancer cells via induction of apoptotic cell death which was accompanied by remarkable enhancement of Bax and suppression of Bcl-2. Yes The overexpression of PTCSC3 caused a significant (p < 0.05) decline in the proliferation of the human oral cancer cells via induction of apoptotic cell death which was accompanied by remarkable enhancement of Bax and suppression of Bcl-2. 33747284 PTCSC1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines regulation[Akt signaling] CCK8//qRT-PCR//Western Blot//Transwell Assay Here, we identified that lncRNA PTCSC1 was elevated in ESCC tissues and cell lines compared with adjacent noncancerous tissues and normal esophageal epithelial cell line, respectively.In summary, our findings demonstrated PTCSC1 as an oncogenic lncRNA in ESCC via activating Akt signaling and suggested that targeting PTCSC1 represents a promising therapeutic strategy against ESCC. Yes Enhanced expression of PTCSC1 facilitated ESCC cells proliferation and migration in vitro and ESCC xenograft growth in vivo. 32971114 PTAR LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Interaction(miR-101) Western Blot//Transfection//Wound Healing Assay//Migration Assay//Flow Cytometry//qRT-PCR//Cell Proliferation Assay//Cell Cycle Assay//Invasion Assay The results showed that PTAR expression was aberrantly ascended in cervical cancer tissues and cell lines (Caski, SW756, SiHa, C33A and HeLa cells). Furthermore, PTAR could act as an endogenous sponge by directly binding to miR-101 and downregulating miR-101 expression. Yes Overexpressed PTAR could promote cell proliferation, migration and invasion in HeLa cells, which were suppressed by PTAR knockdown. Moreover, cell cycle progression stalled at the G1-G0 phase could be released with PTAR overexpression. 34323178 PSMG3-AS1 LncRNA Homo sapiens lung squamous cell carcinoma LUSC specimens Expression(highly expressed) Bioinformatics Analysis//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay PSMG3-AS1 was found to be upregulated in LUSC, and high expression was associated with positive lymph node metastasis and a higher TNM stage. PSMG3-AS1 was found to be upregulated in LUSC, and high expression was associated with positive lymph node metastasis and a higher TNM stage. Yes Furthermore, inhibiting PSMG3-AS1 expression reduced tumor cell proliferative, migratory and invasive abilities. 34539855 PTAR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung tissues and cell lines Interaction[sponging microRNA‑101] qRT-PCR//Luciferase Report Assay//Transwell Assay Furthermore, our results demonstrated that in human NSCLC tissues and cell lines, lncRNA PTAR expression was upregulated compared with normal lung tissues and cell lines, respectively. The luciferase activity assay revealed that PTAR could act as a sponge to bind miR‑101. Thus, miR‑101 plays a role in NSCLC tumorigenesis and progression. In conclusion, lncRNA PTAR was proposed to promote NSCLC cell growth through sponging and inactivating miR‑101, which may be a possible mechanism underlying miR‑101 copy loss in human NSCLC. Yes Additionally, PTAR transfection was observed to promote A549 cell proliferation, migration and invasion; opposing effects were observed with siRNA‑PTAR transfection. 31485653 PSTPIP1 LncRNA Homo sapiens Breast Neoplasms TNBC tissues,blood Interaction[downregulating miR-34a] Migration Assay//CCK8//qRT-PCR//Invasion Assay//Transwell Assay PAPAS was upregulated in tumour tissues of patients with TNBC versus tumour-adjacent healthy tissues. Plasma PAPAS levels were also upregulated in patients with TNBC versus healthy controls. MiR-34a was downregulated in tumour tissues versus adjacent healthy tissues, and was significantly correlated with PAPAS in tumour tissues. PAPAS overexpression in vitro was associated with miR-34a inhibition, while miR-34a failed to significantly affect PAPAS levels.MiR-34a overexpression decreased the enhanced cell migration and invasion associated with PAPAS overexpression. Yes PAPAS overexpression promoted in vitro migration and invasion of TNBC cells, while miR-34a overexpression was inhibitory. 31248310 PSTPIP1 LncRNA Homo sapiens Thyroid Cancer, Papillary patients with PTC Expression[lower expressed] qRT-PCR PAPAS was downregulated, while the lncRNA HOXA transcript at the distal tip (HOTTIP) was upregulated in patients with PTC. PAPAS expression level decreased, while HOTTIP expression level increased with the increase of clinical staging. Yes PAPAS overexpression led to the inhibition of cell proliferation, while HOTTIP overexpression increased proliferation of PTC cells, and HOTTIP overexpression decreased the effects of PAPAS overexpression. 32194727 PSTPIP1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,blood Interaction[miR-188-5p] qRT-PCR In the present study, we found that PAPAS was upregulated both in plasma from patients with HCC and tumors compared with plasma from healthy people and tumor-adjacent healthy tissues.Rescue experiment showed that miR-34a overexpression attenuated the effects of PAPAS overexpression. However, PAPAS overexpression failed to affect significantly cancer cell migration and invasion. Therefore, lncRNA PAPAS promotes HCC by interacting with miR-188-5p. Yes PAPAS overexpression promoted, while miR-188-5p overexpression inhibited the HCC cell proliferation. 30920025 PSTPIP1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck blood Interaction[upregulating TGF-β1] qRT-PCR In the present study we showed that plasma PAPAS and transforming growth factor β1 (TGF-β1) were both upregulated in patients with OSCC, and were positively correlated only in patients with OSCC. Therefore, lncRNA PAPAS may promote OSCC by upregulating TGF-β1. High plasma levels of PAPAS were followed by low overall survival rate. Yes PAPAS overexpression and exogenous TGF-β1 treatment led to promoted invasion and migration of OSCC cells. 31099126 PSMG3-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tumor tissues and cell lines Interaction[ as a sponge for miR‑143‑3p ] CCK8//qRT-PCR//Western Blot//Migration Assay The results of the present study demonstrated that PSMG3‑AS1 expression was increased in breast cancer tumor tissues and cell lines. In conclusion, the results of the present study identified a novel lncRNA PSMG3‑AS1, which serves as a sponge for miR‑143‑3p in the pathogenesis of breast cancer. PSMG3‑AS1 may be used as a potential therapeutic target gene in breast cancer treatment. Yes Knockdown of PSMG3‑AS1 increased the level of miR‑143‑3p expression, which led to the mitigation of proliferation and migration capacity in breast carcinoma cells. 31661146 PSMG3-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues interaction[miR-143-3p ] CCK8//qRT-PCR//Colony Formation Assay We found that PSMG3-AS1 was upregulated, while miR-143-3p was downregulated in HCC.miR-143-3p may target PSMG3‑AS1 to inhibit the proliferation of HCC cells. High expression levels of PSMG3?AS1 predicted poor survival. Yes In HCC cells, overexpression of PSMG3-AS1 led to increased proliferation rates. 32801875 PSMG3-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues regulation[MiR-449b-5p] CCK8//qRT-PCR We found that upregulation of PSMG3-AS1 in LUAD predicted the poor survival of patients. Therefore, miR-449b-5p may target PSMG3-AS1 in LUAD to suppress cancer cell proliferation. We found that upregulation of PSMG3-AS1 in LUAD predicted the poor survival of patients. Yes Cell proliferation analysis showed that overexpression of PSMG3-AS1 resulted in increased rate of cell proliferation. 32471413 PROX1-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissue Interaction(MiR-1305) CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Compared with adjacent tissues (P < 0.05), the expression of PROX1-AS1 in lung cancer tissue was remarkably higher, while the expression of miR-1305 was remarkably lower (P < 0.05). The dual luciferase experiment confirmed that PROX1-AS1 had a targeting relationship with miR-1305. After cotransfection with si-PROX1-AS1 and anti-miR-1305, the cell viability, migration and invasion ability were remarkably enhanced (P < 0.05), the apoptosis rate was remarkably reduced (P < 0.05), CyclinD1, MMP-2, Bcl-2, and MMP-9 protein were increased remarkably (P < 0.05), and p21 or Bax protein was lowered remarkably (P < 0.05). Yes After PROX1-AS1 knockdown expression or miR-1305 overexpression, cell activity, migration, and invasion ability were outstandingly lowered (P < 0.05), but the apoptosis rate was obviously raised (P < 0.05), CyclinD1, MMP-2, Bcl-2, and MMP-9 protein data were remarkably reduced (P < 0.05), but p21 and Bax protein conditions were outstandingly enhanced (P < 0.05). 35281529 PROX1-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary thyroid cancer cells Expression[highly expressed] qRT-PCR In the present study, we found that PROX1-AS1 levels were obviously increased in thyroid cancer cells compared with the normal thyroid epithelial cells. Yes Knockdown of PROX1-AS1 gene expression by siRNA could inhibit cell proliferation. 30061172 PVT1 LncRNA Homo sapiens Atherosclerosis AS patients and HUVECs Interaction(miR-30 c-5p) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//ELISA lncRNA PVT1 was overexpressed in the serum of AS patients and in ox-LDL-stimulated HUVECs relative to controls. Moreover, miR-30 c-5p was verified as a direct target of lncRNA PVT1. Furthermore, we observed that miR-30 c-5p expression was lower in AS patients than in controls. In addition, the influence of lncRNA PVT1 knockdown on ox-LDL-treated HUVECs was significantly reversed by downregulation of miR-30 c-5p. Yes Knockdown of lncRNA PVT1 facilitated proliferation, reduced apoptosis, and secretion of inflammatory factors in ox-LDL-treated HUVECs. 35038974 circCNN2 CircRNA Homo sapiens lung squamous cell carcinoma LUSC cells Interaction(miR-184/E2F1/MAPK ) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Results demonstrated that circCNN2 was upregulated in LUSC cells, and it promoted LUSC cell proliferation and invasion. Besides, circCNN2 acted as a competing endogenous RNA (ceRNA) to sponge miR-184 to upregulate E2F transcription factor 1 (E2F1) expression. Furthermore, it was verified that circCNN2 activated the generic mitogen-activated protein kinases (MAPK) signaling pathway through E2F1 and thus promoting LUSC progression. Yes Results demonstrated that circCNN2 was upregulated in LUSC cells, and it promoted LUSC cell proliferation and invasion. 36016851 circTXNDC11 CircRNA Homo sapiens Kidney Neoplasms RCC tissues and cell lines Expression [highly expressed] In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Cell Apoptosis Assay//Transwell Assay The current data showed that circTXNDC11 was overexpressed in RCC tissues and cells. The overexpression of circTXNDC11 is linked to advanced TNM stage and lymph node metastasis of renal cancer. Yes Knocking down circTXNDC11 suppressed cell proliferation and invasion in vitro and reduced tumor growth in vivo. Mechanistically, circTXNDC11 promoted RCC growth and invasion by activating the MAPK/ERK pathway. 34308775 PRECSIT LncRNA Homo sapiens Stomach Neoplasms Interaction[ KLF5, MYC/LINC00346/miR-34a-5p cross-talk ] RNA Pull-Down//Western Blot//Wound Healing Assay//Invasion Assay//Migration Assay//Flow Cytometry//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//RNA-seq//EdU Staining//ChIP Gene Set Enrichment Analysis (GSEA) in the GEO datasets revealed that cell cycle and focal adhesion genes were enriched in patients with high LINC00346 expression.Taken together, our findings support a model in which the KLF5, MYC/LINC00346/miR-34a-5p cross-talk served as critical effectors in GC tumorigenesis and progression, suggesting a new therapeutic direction in the treatment of GC. Yes In vitro and in vivo assays of LINC00346 alterations revealed a complex integrated phenotype affecting cell growth, migration and invasion. 30770877 PRECSIT LncRNA Homo sapiens Glioma regulation[LINC00346/miR-128-3p/SZRD1 axis] qRT-PCR//Luciferase Report Assay//RIP//Western Blot LINC00346/miR-128-3p/SZRD1 axis played a crucial role in modulating the malignant progression of glioma, which may serve as a prognostic indicator and a probable therapeutic target for glioma. We found that both LINC00346 and SZRD1 expression were negatively related to the poor overall survival rate in glioma patients. Yes LINC00346 knockdown remarkably restrained cell proliferation both in vitro and in vivo, as well as inducing apoptosis by acting as a molecular sponge of miR-128-3p. 33015801 PRECSIT LncRNA Homo sapiens Glioma glioma tissues and cells Expression(highly expressed) IHC//Transfection//Migration Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay Fluorescence in situ hybridization (FISH) and immunohistochemical staining showed that LINC00346 was highly expressed in high-grade glioma, while type 2 macrophages key transcription factor STAT3 and surface marker CD204 were also highly expressed simultaneously. Yes LINC00346 high-expression gliomas were more sensitive to the anti-PD-1 and anti-CTLA-4 therapy. LINC00346 was also associated with tumor proliferation and tumor migration validated by EdU, cell colony, formation CCK8, and transwell assays. 36311792 PRECSIT LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and serums Expression[highly expressed] qRT-PCR//MTT The results showed that LINC00346, LINC00578, and LINC00673 were highly expressed, whereas LINC00671, LINC00261, and SNHG9 were lowly expressed in PC tissues and serums, and their expression levels were correlated with clinical stages. Survival analysis indicated that patients with high expression of LINC00346, LINC00578, or LINC00673 had significantly lower survival rate, while patients with high expression of LINC00671, LINC00261, and SNHG9 had significantly higher survival rate. Yes In addition, we also found that silence of LINC00346, LINC00578 and LINC00673 inhibited PC cell proliferation, and silence of LINC00671, LINC00261, and SNHG9 promoted PC cell proliferation. 30210701 PRECSIT LncRNA Homo sapiens Pancreatic Neoplasms Interaction[sponging miR-188-3p to derepress BRD4] Western Blot//qRT-PCR//RIP//FISH//MTT//Luciferase Report Assay//Colony Formation Assay LINC00346 shows the ability to promote pancreatic cancer growth and gemcitabine resistance, which is in part mediated by antagonization of miR-188-3p and induction of BRD4. Targeting LINC00346 may improve gemcitabine-based therapeutic efficacy. Yes Overexpression of LINC00346 significantly enhanced the proliferation, colony formation, and tumorigenesis of pancreatic cancer cells. Conversely, knockdown of LINC00346 suppressed pancreatic cancer cell proliferation and caused a cell-cycle arrest at the G2/M-phase. 30728036 PRECSIT LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(miR-30c-2-3/ MYBL2) In Vivo Experiment//IHC//Western Blot//Transfection//CCK8//qRT-PCR//FISH//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay LINC00346 was upregulated in LUAD tissues and cells and was mainly localized in the cytoplasm. LINC00346 sponged miR-30c-2-3 by targeting MYBL2 and regulating CELL CYCLE signaling pathway. Inhibiting miR-30c-2-3p or overexpressing MYBL2 could reverse the inhibitory effect of LINC00346 knockdown on LUAD process. Yes Knockdown of LINC00346 inhibited tumor growth in vivo, proliferation, metastasis and cell cycle progression, while induced apoptosis. 34631522 PRECSIT LncRNA Homo sapiens Skin Neoplasms cell lines Regulation[STAT3 Signaling] qPCR//RNA-seq//Western Blot The expression of LINC00346 was up-regulated in cSCC cells compared with normal human epidermal keratinocytes. Knockdown of LINC00346 inhibited expression of activated STAT3 and resulted in down-regulation of the expression of matrix metalloproteinase (MMP)-1, MMP-3, MMP-10, and MMP-13. Based on these observations LINC00346 was named p53 regulated carcinoma-associated STAT3-activating long intergenic non-protein coding transcript (PRECSIT). These results identify PRECSIT as a new p53-regulated lncRNA, which promotes progression of cSCC via STAT3 signaling. Yes Knockdown of LINC00346 inhibited invasion of cSCC cells in culture and suppressed growth of human cSCC xenografts in vivo. 31837949 circSOX2 CircRNA Homo sapiens lung squamous cell carcinoma Cell lines Interaction(mSOX2) Flow Cytometry//In Vivo Experiment CircSOX2 originates in the reverse strand of the SOX2 gene and its sequence was reverse complement to partial 3'UTR of SOX2-coding transcript (mSOX2). CircSOX2 bound to AUF1 and occupied in the 3'UTR of mSOX2, inducing the degradation of mSOX2. Patients with SOX2-CAN LUSC expressing circSOX2 manifested increased survival outcomes. Yes CircSOX2 suppressed the proliferation, metastasis, and sphere formation in SOX2-amplified LUSC in vitro and in vivo. 36243874 hsa_circ_0065217 CircRNA Homo sapiens Kidney Neoplasms RCC tissue and cell lines Interaction(miR-214-3p-ALPK2 axis) RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay Hsa_circ_0065217 was abundantly expressed in RCC tissue and cell lines, and its expression linked to advanced TNM stages, large tumor sizes, and lymph-node metastasis. Mechanistically, hsa_circ_0065217 promoted alpha protein kinase 2 (ALPK2) expression via its competing endogenous RNA (ceRNA) activity toward miR-214-3p. its expression linked to advanced TNM stages, large tumor sizes, and lymph-node metastasis. Yes Hsa_circ_0065217 silencing reduced in vitro RCC cell-line growth and aggressiveness. 34705617 PRDM16-DT LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Regulation[PI3K-ATK signaling pathway] qRT-PCR Finally, a xenograft model was used to analyze the antitumor role of LINC00982 in vivo Here, we found that LINC00982 was decreased in human PTC tissues. Taken together, our findings demonstrated that overexpression of LINC00982 could suppress cell proliferation and induce cell apoptosis by regulating PI3K/AKT signaling pathway in PTC. Patients with decreased LINC00982 expression levels had a reduced OS (P=0.0019) compared with those with high LINC00982 expression levels. Yes Knockdown of LINC00982 promoted the proliferation and migration of BHT101 and B-CPAP cells and induced cell apoptosis. Moreover, in vivo assay showed that overexpression of LINC00982 could suppress the growth of PTC. 31262968 circPVT1 CircRNA Homo sapiens lung squamous cell carcinoma LUSC tissues, serum, and cell lines Interaction(miR-30d/e) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//RNA-seq//IHC//EdU Staining Our data showed that circPVT1 was upregulated in LUSC tissues, serum, and cell lines. Additionally, mechanistic analysis showed that HuR regulated circPVT1. On the other hand, circPVT1 acted as a competing endogenous RNA (ceRNA) of miR-30d and miR-30e in alleviating the suppressive influences of miR-30d and miR-30e on its target cyclin F (CCNF). patients with higher circPVT1 expression exhibited shorter survival rates. Yes The in vivo and in vitro data revealed that circPVT1 promotes the proliferation of LUSC cells. 34112238 PRAL LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues Expression[lower expressed] qRT-PCR PRAL expression levels were prominently decreased in a majority of the NSCLC tumor tissues compared with corresponding adjacent normal tissues (p < 0.0001) and healthy tissues (p < 0.0001). Receiver operating characteristic (ROC) curve analyses indicated strong separation between the NSCLC tissues and the control group, with an AUC of 0.8546 (95% CI: 0.7993 to 0.9098; p < 0.0001) for PRAL. Using the Chi-square test showed an obvious negative correlation between down-regulated PRAL levels and advanced TNM stage (χ2 = 8.826, p = 0.003). High PRAL levels had a longer median OS and median PFS (median OS, 42 months vs. 33.5 months, p = 0.0122; median PFS, 30 months vs. 24.5 months, p = 0.0317). Univariate and multivariate analysis of clinical pathological factors were also performed. Yes In addition, over-expression of PRAL blocked proliferation，migration, and invasion in NSCLC cell lines. 30274002 PRADX LncRNA Homo sapiens Gliosarcoma GBM tissues and cells Interaction(STAT3/BLCAP ) In Vivo Experiment//IHC//Western Blot//Transfection//Co-IP//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//ChIP Here, we found that lncRNA PRADX was overexpressed in the mesenchymal GBM and was transcriptionally regulated by RUNX1-CBFβ complex, overexpressed PRADX suppressed BLCAP expression via interacting with EZH2 and catalyzing trimethylation of lysine 27 on histone H3 (H3K27me3). Moreover, we showed that BLCAP interacted with STAT3 and reduced STAT3 phosphorylation, overexpressed PRADX activated STAT3 phosphorylation, and promoted ACSL1 expression via suppressing BLCAP expression, accelerating tumor metabolism.Collectively, PRADX/PRC2 complex activated the STAT3 pathway and energy metabolism in relation to mesenchymal GBM progression. Yes Finally, we determined that combined of ACSL1 and CPT1 inhibitors could reverse the accelerated cellular metabolism and tumor growth induced by PRADX overexpression in vivo and in vitro. 35574370 PRAC2 LncRNA Homo sapiens Glioma glioma tissues and cells interaction[EZH2 ] qRT-PCR//RIP//ChIP We showed that HOXB13-AS1 was significantly upregulated in glioma tissues and cells and was negatively correlated with its surrounding gene HOXB13 levels. Mechanistically, we showed that HOXB13-AS1 overexpression increased DNMT3B-mediated methylation of adjacent gene HOXB13 promoter by binding with the enhancer of zeste homolog 2 (EZH2) using bisulfite sequencing PCR (BSP), epigenetically suppressing HOXB13 expression. Yes Functional experiments in vitro and in vivo revealed that high level of HOXB13-AS1 increased cell proliferation and tumor growth by promoting cell cycle progression. 30105866 circTIMELESS CircRNA Homo sapiens lung squamous cell carcinoma LUSC tissues and LUSC cells regulation[miR-136-5p/ROCK1 axis] qRT-PCR In our study, circTIMELESS (also named hsa_circ_0000408 in the Human circRNA Database) was upregulated in both LUSC tissues and LUSC cells, and circTIMELESS expression was positively associated with the TNM stage. Consequently, our findings confirmed that circTIMELESS exists in LUSC and acts as a tumor promoter through the miR-136-5p/ROCK1 axis. In our study, circTIMELESS (also named hsa_circ_0000408 in the Human circRNA Database) was upregulated in both LUSC tissues and LUSC cells, and circTIMELESS expression was positively associated with the TNM stage. Yes Moreover, circTIMELESS silencing markedly suppressed invasion in vitro and disrupted proliferation in vitro as well as in vivo. 31960961 Ppp2r2b-206 CircRNA Rattus norvegicus Acute Kidney Injury AKI rats Interaction(miR-148a/Rcan2 axis) RNA Pull-Down//TUNEL//Western Blot//ISH//Transfection//Tunel//qRT-PCR//RIP//FISH//PCR//IP//IF CIRC-Ttc3 expression was down-regulated, and upregulation of CIRC-Ttc3 improved inflammatory responses and oxidative stress in AKI rats. Mechanismly, CIRC-Ttc3 was confirmed to bind to and negatively regulate miR-148a. Further rescue assays revealed that overexpression of miR-148a rescued the improvement of CIRC-Ttc3 on sepsis-induced AKI. Then, it was illustrated that CIRC-Ttc3 regulated Rcan2 expression by binding to miR-148a. Yes CIRC-Ttc3 expression was down-regulated, and upregulation of CIRC-Ttc3 improved inflammatory responses and oxidative stress in AKI rats. 33600863 PPP1R3B-DT LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Expression(highly expressed) In Vivo Experiment//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//FISH//MTT//IHC//Transwell Assay Expression of RP11-10A14.5 is correlated with increased clinical stage and poor survival prognosis. Immunofluorescence assay suggested that RP11-10A14.5 may promote EMT by downregulating E-cadherin and upregulating N-cadherin and Vimentin. Flow cytometry results suggested that RP11-10A14.5 did not significantly affect cell cycle function, but could significantly inhibit apoptosis which may further enhance metastasis cell survival. Expression of RP11-10A14.5 is correlated with increased clinical stage and poor survival prognosis. Yes In vitro experiments revealed that RP11-10A14.5 was widely expressed in lung cancer cell lines and mainly distributed in the cytoplasm and enhanced the growth, invasion and migration ability of NSCLC cell lines. 35575835 PRH1-PRR4 CircRNA Homo sapiens lung non-small cell carcinoma NSCLC tissues and cells Interaction(miR-877-5p/RAB3D) In Vivo Experiment//IHC//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Invasion Assay//Transwell Assay As compared with controls, NSCLC tissues and cells displayed high expression of circPRH1-PRR4 and RAB3D, and low expression of miR-877-5p. In support, circPRH1-PRR4 silencing inhibited tumor formation in vivo. Knockdown of miR-877-5p, a target miRNA of circPRH1-PRR4, relieved circPRH1-PRR4 absence-mediated action. Additionally, RAB3D was identified as a target mRNA of miR-877-5p. Importantly, circPRH1-PRR4 regulated RAB3D expression by miR-877-5p. Yes Reduced expression of circPRH1-PRR4 resulted in inhibition of cell proliferation, migration, and invasion, but promotion of cell apoptosis in vitro. 35076987 PRINS LncRNA Homo sapiens Diabetes Mellitus blood Interaction[Smad7] qRT-PCR//MTT//Western Blot In addition, the expression levels of PRINS and Smad7 were significantly increased in patients with diabetic nephropathy compared with other diabetic complications. A significant positive correlation between the expression level of PRINS and Smad7 was observed in patients with diabetic nephropathy. Overexpression of PRINS decreased the viability of mouse podocyte cells and enhanced Smad7 protein expression. Yes Overexpression of PRINS decreased the viability of mouse podocyte cells and enhanced Smad7 protein expression. 30936994 PROX1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-520d/PD-L1) CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, both PROX1-AS1 and PD-L1 expressions were lifted in CRC tissues and cells. To sum up, this study affirmed that PROX1-AS1 could absorb miR-520d to upregulate PD-L1 in CRC, thereby promoting tumor progression and immune escape. Yes PROX1-AS1 interference restrained CRC cell proliferation, migration, invasion, as well as CD8 + T-lymphocyte apoptosis, but increased the cytotoxicity and percentage of CD8 + T lymphocytes. The inhibitory effects of PROX1-AS1 inhibition on CRC progression and immune escape were positively related to PD-L1 suppression. 36730426 hsa-circ_0058106 CircRNA Homo sapiens Laryngeal Neoplasms laryngeal cancer tissues Interaction(miR-153/Snail1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//IHC//Invasion Assay A high level of hsa-circ_0058106 was found to be associated with lymph node metastasis and advanced clinical stages. Mechanistically, we found that hsa-circ_0058106 can specifically bind to miR-153 and regulate Snail1 expression by acting as a miR-153 sponge. In addition, we found that knockdown of hsa-circ_0058106 blocked the nuclear translocation of Twist1. A high level of hsa-circ_0058106 was found to be associated with lymph node metastasis and advanced clinical stages. Yes Stable knockdown of hsa-circ_0058106 inhibited the migration and invasion of laryngeal cancer cells in vitro and in vivo. 34738200 PRNCR1-2 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] qRT-PCR//Western Blot The results demonstrated that PRNCR1‑2 expression was significantly elevated in breast cancer tissues compared with in adjacent normal tissues. In addition, PRNCR1‑2 depletion increased CHK2 phosphorylation and decreased AKT phosphorylation in HS‑578T and MDA‑MB‑231 cells. In conclusion, the lncRNA PRNCR1‑2 may promote breast cancer cell proliferation, migration, invasion and cell cycle progression. Yes Furthermore, depletion of PRNCR1‑2 in HS‑578T and MDA‑MB‑231 breast cancer cells markedly suppressed their proliferation rates, migration and invasion capacities, and cell cycle progression; however, it had no effect on cell apoptosis. 30592261 PRNCR1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines(BT-549, MCF-7, SK-BR-3 and MDA-MB-231) Expression[highly expressed] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The results of the present study revealed that PRNCR1 expression levels were higher in breast cancer tissues compared with adjacent normal tissues in a patient study.In vitro experiments determined that PRNCR1 was significantly upregulated in the breast cancer cell lines BT-549, MCF-7, SK-BR-3 and MDA-MB-231 compared with the normal human breast cell line, MCF-10A. It was also determined that high expression of PRNCR1 was significantly associated with advanced clinical stage, positive metastasis and poor prognosis for patients with breast cancer. Yes Silencing of PRNCR1 significantly inhibited the proliferation, colony formation, cell cycle progression, migration and invasion of SK-BR-3 and BT-549 cells, while cell apoptosis was induced. In addition, knockdown of PRNCR1 suppressed epithelial-mesenchymal transition in SK-BR-3 and BT-549 cells. 31798697 PRNCR1 LncRNA Homo sapiens Breast Neoplasms patients with breast cancer Interaction(microRNA-377/CCND2/MEK/MAPK Axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Flow Cytometry//RIP//Luciferase Report Assay PRNCR1 was highly expressed and miR-377 was poorly expressed in patients with breast cancer, and patients with high expression of PRNCR1 had a poor prognosis. PRNCR1 regulated CCND2 expression by competitively binding to miR-377. CCND2 activated the MEK/MAPK pathway, and after treatment with Mirdametinib, the MEK/MAPK pathway was inhibited, which was found to retard breast cancer growth. Yes PRNCR1 silencing or miR-377 overexpression resulted in suppressed breast cancer cell proliferation ability, blocked cell cycle process and induced apoptosis. 33608112 PRNCR1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[PRNCR1/miR-126-5p/MTDH axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay PRNCR1 and MTDH levels were highly expressed, while miR-126-5p expression was lowly expressed in NSCLC tissues and cell lines.PRNCR1 modified cell behaviors and EMT via miR-126-5p/MTDH axis in NSCLC cells, providing a novel thinking for clinical treatment of NSCLC. Yes Knockdown of PRNCR1 promoted cell apoptosis, impeded proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in NSCLC cells, and these effects were abrogated by its target gene of miR-126-5p inhibitor. 31912882 PRNCR1 LncRNA Homo sapiens Ovarian Neoplasms OC cell lines and tissues Interaction(miR-653-5p/ELF2 axis) qRT-PCR//Wound Healing Assay//Colony Formation Assay Our results demonstrated that PRNCR1 was significantly upregulated in both OC cell lines and tissues, and high expression of PRNCR1 was correlated with poor survival of OC patients.Besides, the expression of PRNCR1 was negatively correlated with the expression of miR-653-5p, while positively correlated with the expression of E74-like factor 2 in OC tissues. Importantly, ELF2 could target miR-653-5p, and PRNCR1 increased the expression levels of ELF2 by sponging miR-653-5p in OC cells. Furthermore, the miR-145-5p/ELF2 axis was involved in the regulation of PRNCR1 in OC progression in vivo. Our results demonstrated that PRNCR1 was significantly upregulated in both OC cell lines and tissues, and high expression of PRNCR1 was correlated with poor survival of OC patients. Yes Overexpression of PRNCR1 accelerated OC cell invasion, migration and proliferation. PRNCR1 promotes OC tumor progress via the miR-653-5p/ELF2 axis and might be a potential therapeutic target for OC. 35166984 PRMT5 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-188-5p/HK2 axis] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay Circ-PRMT5 was elevated in HCC tissues and cells than matched control groups. In summary, circ-PRMT5 might play a key role in proliferation, migration, glycolysis of HCC cells via miR-188-5p/HK2 axis, which indicated that circ-PRMT5 might be a potential therapeutic target for HCC treatment. Yes Furthermore, loss-of-functional experiments revealed that the silencing of circ-PRMT5 could repress proliferation, migration, glycolysis in vitro and tumor growth in vivo. 32089501 PRMT5 CircRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues and cell lines interaction[binding miR-203] qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Transwell Assay Circ-PRMT5 was upregulated in esophageal cancer tissues and cell lines. Circ-PRMT5 is positively correlated to the rates of lymphatic metastasis and distant metastasis of esophageal cancer. It promotes migratory ability in esophageal cancer by targeting miR-203. The expression level of circ-PRMT5 was positively correlated to the rates of lymphatic metastasis and distant metastasis of esophageal cancer. Yes Knockdown of circ-PRMT5 attenuated migratory abilities in TE-1 and OE33 cells. 33090401 circRANBP9 CircRNA Homo sapiens Laryngeal Neoplasms LC cell lines tissues Expression(lower expressed) Western Blot//Bioinformatics Analysis//Transfection//Wound Healing Assay//Invasion Assay//Migration Assay//CCK8//qRT-PCR//FISH//EdU Staining Circ-RANBP9 was downregulated in the LC cell lines tissues, relating to a better prognosis. Circ-RANBP9 was downregulated in the LC cell lines tissues, relating to a better prognosis. Yes Circ-RANBP9 was found to inhibit the proliferation, migration, and invasion ability of LC, exerting a suppressive role in the epithelial to mesenchymal transition process as well. 33850881 PRKG1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cell lines(CAL27, SCC-9, and SCC-4 ) Expression[highly expressed] CCK8//qRT-PCR//Western Blot//Transwell Assay The expression of PRKG1-AS1 was higher in CAL27, SCC-9, and SCC-4 than that in normal human oral keratinocytes (NHOK). Yes The results of biological experiments showed that deficiency of PRKG1-AS1 suppressed cell growth, invasion, and migration in CAL27 cells, and over-expression of PRKG1-AS1 accelerated cell growth, invasion, and migration in SCC-4 cells. 31788859 hsa_circ_0023028 CircRNA Homo sapiens Laryngeal Neoplasms LCa tissues and cell lines Interaction[sponging miR-194-5p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In the present study, we demonstrated that hsa_circ_0023028 expression was up-regulated in LCa tissues and cell lines. In summary, hsa_circ_0023028 functions as an miR-194-5p sponge to promote the proliferation, migration, and invasion of LCa cells. Yes Functionally, knockdown of hsa_circ_0023028 inhibited the proliferation, migration, and invasion of LCa cells, as evidenced by the reduced number of 5-Ethynyl-2'-deoxyuridine (EdU)-positive cells and decreased number of migrated and invaded cells. 31123169 PRKCSH CircRNA Homo sapiens Spinal Cord Injuries injured cells Interaction(miR-488/Ccl2) RNA Pull-Down//Transfection//qPCR//PCR//IP//IF Our results revealed an elevated expression of circPrkcsh with a concurrent decrease in miR-488 expression in injured cells. We also found that circPrkcsh regulated the expression of the inflammation-related gene Ccl2. Furthermore, circPrkcsh may be used as an miR-488 sponge to regulate Ccl2 expression, which might provide a new potential therapy for SCI. Yes Furthermore, in tumor necrosis factor-α-treated astrocytes, circPrkcsh knockdown decreased the expression of Ccl2 by upregulating miR-488 expression, and reduced the secretion of inflammatory cytokines in vitro. 34100450 PRKCQ-AS000 LncRNA Homo sapiens Colorectal Neoplasms CRC cells and tissues regulation[miR-1287-5p/YBX1 axis] qRT-PCR Long noncoding RNA (lncRNA) PRKCQ-AS1 was heightened in CRC cells and tissues and related with dismal prognosis of CRC patients.Rescue assays in vitro and in vivo showed that overexpression of YBX1 could partly offset the effect of CRC progression induced by knocking down PRKCQ-AS1, demonstrating PRKCQ-AS1 mediating CRC progression via miR-1287-5p/YBX1 pathway. Yes Knockdown of PRKCQ-AS1 would induce a decrease in proliferative and migrating ability of CRC cells. 32619070 hsa_circ_0004507 CircRNA Homo sapiens Laryngeal Neoplasms laryngeal cancer tissues Interaction(miR-873) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay circ_0004507 was highly expressed and miR-873 was lowly expressed in laryngeal cancer tissues. miR-873 was identified as a direct target of circ_0004507. circ_0004507 interference inhibited tumor growth and promoted cisplatin sensitivity by upregulating miR-873 in vivo. Yes circ_0004507 knockdown or miR-873 overexpression inhibited cell proliferation, migration and invasion, and increased apoptosis and cisplatin sensitivity in laryngeal cancer cells. 33247530 circPVT1 CircRNA Homo sapiens Laryngeal Neoplasms LC tissues and cells. Regulation(wnt4/β-Catenin Signaling Pathway) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//ELISA//Colony Formation Assay//EdU Staining//Transwell Assay "The upregulation of circ_PVT1 was found in LC tissues and cells.Silencing of circ_PVT1 inhibited LC progression via targeting miR-21-5p and indirectly controlling CBX4. Wnt4/β-catenin signal pathway was inactivated by inhibiting the expression of circ_PVT1. " Yes Silencing of circ_PVT1 inhibited LC progression via targeting miR-21-5p and indirectly controlling CBX4. Wnt4/β-catenin signal pathway was inactivated by inhibiting the expression of circ_PVT1. 34336825 hsa_circ_0000218 CircRNA Homo sapiens Laryngeal Neoplasms LSCC cells regulation[microRNA-139-3p/Smad3 axis] CCK8//qRT-PCR//Luciferase Report Assay//RIP Circ_0000218 was highly expressed in LSCC cells.circ_0000218 inhibition inhibited the growth of LSCC by targeting miR-139-3p/Smad3 axis. Yes Besides, the findings suggested that circ_0000218 silencing inhibited the LSCC cell viability and promoted apoptosis by negatively regulating miR-139-3p expression. 32825967 PRKAR1B LncRNA Homo sapiens Osteosarcoma OS cells Interaction(miR-361-3p/FZD4 axis) qRT-PCR//Luciferase Report Assay//FISH Mechanistic investigations suggested that circPRKAR1B promotes OS progression through sponging miR-361-3p to modulate the expression of FZD4. Subsequently, we identified that EIF4A3 promoted cirPRKAR1B formation through binding to the downstream target of circPRKAR1B on PRKAR1B mRNA. Yes By functional experiments, we found that circPRKAR1B enhanced OS cell proliferation, migration, and promotes OS epithelial-mesenchymal transition (EMT). 34716310 PRKAG2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue specimens Interaction(miR-502-3p/BICD2 axis) qRT-PCR PRKAG2-AS1 was up-regulated in HCC than normal tissue specimens. PRKAG2-AS1 may directly bind to the sites of miR-502-3p. Up-regulation of BICD2 was found in HCC tissues and associated with unfavorable prognosis. BICD2 was confirmed to be a downstream target of miR-502-3p. PRKAG2-AS1 could regulate miR-502-3p/BICD2 axis. PRKAG2-AS1 expression was indicative of poorer OS and DFS time. Yes Targeting PRKAG2-AS1 distinctly inhibited proliferation, migration, and invasion in HCC cells. PRKAG2-AS1 was mainly expressed in cytoplasm of HCC cells. 33928106 PTCSC3 LncRNA Homo sapiens Stomach Neoplasms plasma regulation[suppression of HOXA11-AS] qRT-PCR In the present study, we showed that PTCSC3 was downregulated in plasma of gastric cancer patients than in plasma of healthy controls. Follow-up study indicated that PTCSC3 was further downregulated in patients with distant-recurrence but not in patients with local recurrence only or non-recurrence. Yes PTCSC3 overexpression led to inhibited, while HOXA11-AS overexpression led to promoted migration and invasion of gastric cancer cells. 32368140 PTCSC3 LncRNA Homo sapiens Stomach Neoplasms blood Expression[lower expressed] CCK8//qRT-PCR//Invasion Assay//Transwell Assay The authors found that plasma PTCSC3 was downregulated in gastric cancer patients. Downregulation of PTCSC3 distinguished early stage gastric cancer patients from healthy controls. LncRNA PTCSC3 expression levels were increased on the day of discharge in gastric cancer patients compared with pretreatment levels. During follow-up, patients with low plasma levels of PTCSC3 showed a significantly lower overall survival rate. Yes PTCSC3 negatively regulated proliferation, invasion, and migration of gastric cancer cells. 31702383 PTCSC3 LncRNA Homo sapiens Stomach Neoplasms Gastric Cancer tissues Interaction[Linc-pint ] CCK8//qRT-PCR PTCSC3 and lncRNA Linc-pint were both downregulated in tumor tissues than in adjacent healthy tissues of gastric cancer patients. PTCSC3 and Linc-pint overexpression inhibited tumor growth and cancer cell stemness, while Linc-pint knockdown played an opposite role an attenuated the effects of PTCSC3 overexpression. Expression levels of PTCSC3 and Linc-pint were significantly correlated in tumor tissues but not in adjacent healthy tissues. Overexpression of PTCSC3 and Linc-pint upregulated the expression of each other. Low levels of PTCSC3 and Linc-pint were closely correlated with poor survival. Yes PTCSC3 and Linc-pint overexpression inhibited tumor growth and cancer cell stemness, while Linc-pint knockdown played an opposite role an attenuated the effects of PTCSC3 overexpression. 31849528 PVT1 LncRNA Homo sapiens gastric adenocarcinoma GAC tissues Expression[highly expressed] qRT-PCR//Colony Formation Assay//Transwell Assay LncRNA-PVT1 was upregulated in GACs compared to the matched adjacent normal tissues in the TMA. LncRNA PVT1 expression was positively correlated with larger tumor size, deeper wall invasion, lymph node metastases, and short survival duration. Yes Inhibition of PVT1 using PVT1 ASOs significantly suppressed tumor cell growth and invasion in vitro and in vivo. 33076512 PVT1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Interaction(HIF2α ) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Wound Healing Assay//Tube Formation Assay//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//ELISA//Colony Formation Assay//Invasion Assay//Transwell Assay Here, we identified the potential molecular mechanism of PVT1 in promoting ccRCC development by stabilizing HIF2α. PVT1 was significantly upregulated in ccRCC tissues and high PVT1 expression was associated with poor prognosis of ccRCC patients. Mechanistically, PVT1 interacted with HIF2α protein and enhanced its stability by protecting it from ubiquitination-dependent degradation, thereby exerting its biological significance. Meanwhile, HIF2α bound to the enhancer of PVT1 to transactivate its expression. Here, we identified the potential molecular mechanism of PVT1 in promoting ccRCC development by stabilizing HIF2α. PVT1 was significantly upregulated in ccRCC tissues and high PVT1 expression was associated with poor prognosis of ccRCC patients. Yes Both gain-of-function and loss-of function experiments revealed that PVT1 enhanced ccRCC cells proliferation, migration, and invasion and induced tumor angiogenesis in vitro and in vivo. 34321604 PVT1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC cells Interaction(miR-328-3p/FAM193B) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay We found that PVT1 is upregulated in ccRCC cells and promoted cell proliferation. Our analyses revealed that miR-328-3p was a direct target of PVT1 and that FAM193B was a direct target of miR-328-3p. FAM193B is upregulated in ccRCC tissues and promotes cell proliferation by activating the MAPK/ERK and PI3K/AKT pathways. Yes We found that PVT1 is upregulated in ccRCC cells and promoted cell proliferation 34518442 PVT1 LncRNA Homo sapiens Retinoblastoma RB tissues and cell lines Interaction[sponging miR-488-3p ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining In this study, we found that PVT1 was upregulated in RB tissues and cell lines.The analysis of the mechanisms of action revealed that the reduction of PVT1 inhibited the expression of notch2 by upregulating miR-488-3p. In general, our results demonstrated that PVT1 may be a novel biomarker for prognosis and a new target for the treatment of RB. PVT1 levels correlated with optic nerve invasion, and intraocular international retinoblastoma classify (IIRC) stage. Yes In WERI-Rb1 and Y79 cells, PVT1 silencing significantly inhibited cell proliferation, migration, invasion, and cell cycle progression and induced cell apoptosis in vitro.Moreover, in vivo xenograft assay indicated that PVT1 knockdown suppressed the tumor volume and tumor weight. 30797143 PVT1 LncRNA Homo sapiens Melanoma melanoma tissue and cells Interaction(miR-26b) Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//Colony Formation Assay Expression of PVT1 was significantly upregulated in melanoma tissue and was associated with a poor prognosis.Bioinformatics analysis and dual-luciferase reporter assay revealed that PVT1 directly bound to miR-26b, which had been verified to be a tumor suppressor in melanoma. Moreover, further functional rescue experiments revealed that PVT1 knockdown could observably reverse the tumor-promoting role of the miR-26b inhibitor. Expression of PVT1 was significantly upregulated in melanoma tissue and was associated with a poor prognosis. Yes Loss-of-function experiments showed that PVT1 knockdown markedly suppressed the proliferation activity, induced cell cycle arrest at the G0/G1 phase, and enhanced the apoptosis of melanoma cell lines. 28409552 PVT1 LncRNA Homo sapiens Ischemic Stroke blood regulation[lncRNA PVT1/miR-214/p53] Co-IP//qRT-PCR//Luciferase Report Assay//Western Blot We found that the levels of PVT1 were upregulated and miR-214 levels were downregulated in plasma of AIS patients. PVT1 regulated ferroptosis through miR-214-mediated TFR1 and TP53 expression. There was a positive feedback loop of lncRNA PVT1/miR-214/p53 possibly. Yes PVT1 silencing or miR-214 overexpression significantly reduced infarct size and suppressed ferroptosis in vivo. 32827544 PVT1 LncRNA Homo sapiens Diabetic Nephropathies blood Regulation[upregulating FOXA1] Western Blot//qPCR//Flow Cytometry//FISH//RIP//IF//Luciferase Report Assay//ChIP PVT1 was highly expressed in MPC5 and primary podocytes in DN patients and in cultures grown in high glucose medium. A large number of CpG (C-phosphate-G) island sites were predicted at the FOXA1 promoter region, where PVT1 recruited EZH2 to promote the recruitment of H3K27me3. The silencing of PVT1 or the overexpression of FOXA1 relieved the damage and inhibited the apoptosis of podocytes in DN, as was evidenced by the upregulated expression of synaptopodin and podocin, higher expression of Bcl-2, and lower expression of Bax and cleaved caspase-3. The key findings of this study collectively indicate that the suppression of lncRNA PVT1 exerts inhibitory effects on podocyte damage and apoptosis via FOXA1 in DN, which is of clinical significance. Yes The silencing of PVT1 or the overexpression of FOXA1 relieved the damage and inhibited the apoptosis of podocytes in DN, as was evidenced by the upregulated expression of synaptopodin and podocin, higher expression of Bcl-2, and lower expression of Bax and cleaved caspase-3. 31371698 PVT1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse Human DLBCL tissues Interaction(miR-34b-5p/Foxp1 pathway) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//ChIP In this study, we found PVT1 and Foxp1 were elevated in DLBCL tissues and cells while miR-34b-5p was decreased. Knockdown of PVT1, overexpression of miR-34b-5p, or Foxp1 knockdown repressed DLBCL cell proliferation but enhanced cell apoptosis. PVT1 directly bound miR-34b-5p to disinhibit Foxp1/β-catenin signaling. Foxp1 regulated CDK4, CyclinD1, and p53 expression via binding with their promoters. Knockdown of Foxp1 partially reversed the effects of miR-34b-5p inhibitor on DLBCL cell proliferation and apoptosis. Inhibition of PVT1 through shRNA suppressed DLBCL tumor growth in vivo. All in all, lncRNA PVT1 promotes DLBCL progression via acting as a miR-34b-5p sponge to disinhibit Foxp1/β-catenin signaling. Yes Knockdown of PVT1, overexpression of miR-34b-5p, or Foxp1 knockdown repressed DLBCL cell proliferation but enhanced cell apoptosis. 35098439 PVT1 LncRNA Homo sapiens Sepsis CLP-operated mice and LPS-treated THP-1 cells Interaction(lncRNA PVT1/miR-16-5p/TLR4 axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//H&E Staining//ELISA EGCG inhibited the expression levels of PVT1 and TLR4 and enhanced miR-16-5p expression in CLP-operated mice and LPS-treated THP-1 cells. Mechanistically, PVT1 bound with miR-16-5p to activate TLR4 signaling. Further experiments demonstrated that miR-16-5p silencing or TLR4 overexpression antagonized sh-PVT1 or miR-16-5p mimics-mediated inhibitory effects on inflammatory cytokines, respectively. Yes EGCG reduced the levels of inflammatory cytokines, which were restored by PVT1 overexpression. Knockdown of PVT1 alleviated inflammatory injury in CLP-induced sepsis in mice. 36584452 PVT1 LncRNA Homo sapiens Uveal melanoma uveal melanoma tissues Regulation[p53 signaling pathway] qRT-PCR Highly expressed lncRNA PVT1 and MDM2, yet lowly expressed miR-17-3p, were identified in ocular uveal melanoma tissues versus normal adjacent tissues. Then, dual luciferase reporter gene assay, RNA binding protein immunoprecipitation, and RNA pull-down assays showed that lncRNA PVT1 specifically bound to miR-17-3p, and that MDM2 was a target gene of miR-17-3p. Yes Gain- and loss-of-function studies elucidated that silencing of lncRNA PVT1 or overexpression of miR-17-3p resulted in decreased MDM2 expression and increased transcriptional activity of p53, in addition to inhibiting uveal melanoma cell proliferation, migration, and invasion, yet promoted cell apoptosis in vitro. In addition, lncRNA PVT1 silencing or miR-17-3p overexpression was noted to inhibit tumor growth in vivo. 31770435 PVT1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues and cell lines Interaction(miR-515-5p) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining Plasmacytoma variant translocation 1 expression and high mobility group B3 expression were up-regulated in prostate cancer tissues and cell lines while miR-515-5p expression was down-regulated. Mechanistically, plasmacytoma variant translocation 1 could repress the function of miR-515; high mobility group B3 was proved to be a target gene of miR-515-5p, and its expression could be indirectly positively modulated by plasmacytoma variant translocation 1. Yes . Plasmacytoma variant translocation 1 knockdown restrained the proliferation, migration, and invasion of LNCaP and DU145 cells in vitro, and the transfection with miR-515-5p inhibitors reversed these effects. 36053124 PVT1 LncRNA Homo sapiens Uveal melanoma UM tissues Interaction[inhibiting EZH2] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay  The expression level of lncRNA PVT1 in UM tissues was remarkably higher than that in the adjacent tissues (p<0.05).The protein expression of EZH2 was suppressed after lncRNA PVT1 knockdown (p<0.05). Yes UM cell proliferation was notably repressed after lncRNA PVT1 knockdown by siRNA. Flow cytometry results indicated that the number of apoptotic UM cells in lncRNA PVT1 knockdown group significantly increased compared with that in the blank control group (p<0.05). 31002139 PVT1 LncRNA Homo sapiens Nasopharyngeal Neoplasms NPC tissues and cell lines Interaction[Inhibiting miR-1207] qRT-PCR//MTT//Western Blot PVT1 was significantly up-regulated in both NPC tissues and cell lines and associated with poor prognosis. Yes PVT1 knockdown reduced NPC cells viability, clonogenicity, the cell surface CD44+/CD24- stem phenotype, and the expressions of the stem cell markers in NPC cells, including Oct4, c-Myc, SOX2, and ALDH. 30141114 PVT1 LncRNA Homo sapiens Asthma serum of children with asthma Interaction(miR-590-5p/FSTL1 axis) Transfection//Immunoblotting//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay The expression level of lncRNA PVT1 was higher but the expression level of miR-590-5p was lower in the serum of children with asthma than in control children. These results support the notion that the lncRNA PVT1/miR-590-5p/FSTL1 axis modulates ASMCs proliferation and migration following PDGF-BB stimulation, providing a potential therapeutic target to attenuate airway remodelling in asthma. Yes . LncRNA PVT1 knockdown by its specific shRNA repressed PDGF-BB-induced promotion of proliferation and migration in ASMCs and triggered an elevated miR-590-5p along with declined C-Myc, cyclin D1, and CDK1. 33825599 PVT1 LncRNA Homo sapiens Pituitary Neoplasms Pituitary Adenoma tissues,cell lines Regulation[Wnt/ß-catenin signaling] qRT-PCR The PVT1 expressions were significantly enhanced in tissues of pituitary adenoma and cancer cells.The PVT1 downregulation obviously blocked Wnt/ß-catenin signaling pathway activity. PVT1 aggravated progression of pituitary adenoma through initiating the Wnt/ß-catenin signaling pathway. CONCLUSIONS PVT1 exerts an oncogenic role through activating Wnt/ß-catenin signaling in pituitary adenoma cells. Yes Cell migration and proliferation were inhibited when the PVT1 gene was knocked down. Knockdown of PVT1 repressed the migration and EMT of pituitary adenoma cells. 31604907 PVT1 LncRNA Homo sapiens Precursor Cell Lymphoblastic Leukemia-Lymphoma ALL and ALL cell lines Interaction(miR-486-5p/MAML3) In Vivo Experiment//Immunoblotting//CCK8//qRT-PCR//Luciferase Report Assay PVT1 was upregulated in plasma samples from patients with ALL and ALL cell lines.PVT1 targeted microRNA-486-5p (miR-486-5p) and negatively modulated miR-486-5p expression. Upregulation of miR-486-5p decreased cell viability and increased ALL cell apoptosis. Mastermind Like Transcriptional Coactivator 3 (MAML3) was a downstream molecule of miR-486-5p and miR-486-5p mimic transfection weakened its expression in ALL cells. Yes PVT1 silencing repressed cell viability and enhanced cell apoptosis in Jurkat and SUP-B15 cells. 35152842 PVT1 LncRNA Homo sapiens renal fibrosis cell lines regulation[ TGF-β Signaling Pathway] qRT-PCR//ELISA//Western Blot PVT1 was upregulated in TGF-β1-treated HK-2 cells. In addition, TGF-β1-induced upregulation of α-SMA and fibronectin in HK-2 cells was significantly reversed by PVT1 knockdown. Meanwhile, PVT1 bound to miR-181a-5p in HK-2 cells. Moreover, miR-181a-5p directly targeted TGF-βR1. Yes Besides, knockdown of PVT1 notably attenuated the symptom of renal fibrosis in vivo. 32921988 PVT1 LncRNA Homo sapiens Aortic Aneurysm, Abdominal aortic tissues Expression[highly expressed] CCK8//qRT-PCR Our results also showed that PVT1 expression was significantly upregulated in abdominal aortic tissues from AAA patients compared with that in controls. Yes Furthermore, knockdown of PVT1 reversed Ang II-induced AAA-associated alterations in mice, as evidenced by attenuation of aortic diameter dilation, marked adventitial thickening, loss of elastin in the aorta, enhanced aortic cell apoptosis, elevated MMP-2 and MMP-9, reduced TIMP-1, and increased pro-inflammatory cytokines. 30726659 PVT1 LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocarcinogenesis tissues Regulation[c-Myc/P53/miR-214-PVT1-GDF15 axis] Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay As shown in Supplementary Fig. 2, lncRNA PVT1 was significantly overexpressed in various cancerous tissues including liver hepatocellular carcinoma (LIHC) compared to the normal tissues. Interestingly, we found that c-Myc and P53 could divergently regulate PVT1 transcription. Oncoprotein c-Myc enhances PVT1 expression, whereas P53 suppresses its expression. We also identified miR-214 as a crucial, negative regulator of PVT1. Consistently, high miR-214 levels were significantly correlated with diminished PVT1 expression in HCC specimens. Silencing of PVT1 by ectopic miR-214 or siRNAs markedly inhibited viability and invasion of HCC cells. In opposition, inhibition of endogenous miR-214 promoted PVT1 expression and enhanced cell proliferation. Notably, oncogenic GDF15 is a potential downstream target of the miR-214-PVT1 signaling. Collectively, our results show that the c-Myc/P53/miR-214-PVT1-GDF15 axis is implicated in HCC development, shedding light on the mechanistic actions of PVT1 and representing potential targets for HCC clinical intervention. Yes Silencing of PVT1 by ectopic miR-214 or siRNAs markedly inhibited viability and invasion of HCC cells. 31677796 PVT1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction( miR‑27b‑3p/BLM axis) In Vivo Experiment//RNA Pull-Down//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis The results revealed the high expression level of PVT1 in PCa tissues and cells, and epigenetic analyses revealed the upregulation of PVT1 expression following METTL3?mediated m6A modification. Furthermore, miR‑27b‑3p was found to target both PVT1 and BLM, and PVT1 functioned to sequester miR‑27b‑3p within cells, thereby indirectly promoting the BLM expression level. BLM overexpression reversed the adverse effects of PVT1 knockdown on the migratory, proliferative and invasive capabilities of PCa cells in vitro and in vivo. The overexpression of PVT1 contributed to the aggressive phenotype of PCa cells by regulating the miR‑27b‑3p/BLM axis. Yes PVT1 overexpression induced PCa cells to become more proliferative, migratory and invasive, whereas PVT1 knockdown led to the opposite phenotype. 36484368 PVT1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells regulation[KIF23 ,miR-15a-5p] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expression of PVT1 and KIF23 was enhanced, while miR-15a-5p expression was reduced in PCa tissues and cells.PVT1 knockdown had effects on the progression of PCa by inhibiting the expression of KIF23 via enriching miR-15a-5p in vitro and in vivo, suggesting that PVT1 might be a novel biomarker for the treatment of PCa. Yes PVT1 interference inhibited proliferation, migration and invasion but promoted apoptosis of PCa cells. 32624708 PTEN CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and serum Interaction(miR-155 and miR-330-3p) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//PCR//IP//IHC//IF We found that circ-PTEN (hsa_circ_0094342) was significantly decreased in NSCLC tissues and serum, which was attributed to the upregulation of RNA-binding protein DHX9. Circ-PTEN increased the expression of its host gene PTEN via acting as a sponge for miR-155 and miR-330-3p, leading to the inactivation of the carcinogenic PI3K/AKT signaling pathway  Low circ-PTEN was linked with malignant clinical features and poor outcome Yes Overexpression of circ-PTEN inhibits NSCLC cell proliferation in vitro. 33821441 PVT1 LncRNA Homo sapiens Gallbladder Neoplasms GBC tissues and cells regulation[PVT1/miR-18b-5p/HIF1A regulation axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//ChIP In the present study, we found that PVT1 was upregulated in GBC tissues and cells, and its upregulation was related with poor prognosis in GBC patients.In conclusion, our studies clarified the PVT1/miR-18b-5p/HIF1A regulation axis and indicated that PVT1 could be a potential therapeutic target for GBC. In the present study, we found that PVT1 was upregulated in GBC tissues and cells, and its upregulation was related with poor prognosis in GBC patients. Yes PVT1 promoted GBC cells proliferation in vitro and in vivo. 33067424 PVT1 LncRNA Homo sapiens Thyroid Neoplasms TC tissues and cell lines regulation[ miR-423-5p-PAK3 axis ] qRT-PCR//Western Blot PVT1 and PAK3 upregulated while miR-423-5p downregulated in the tissues and cell lines.In conclusion, PVT1 can mediate the molecular mechanism of the miR-423-5p-PAK3 axis regulatory network on regulating TC, so it is a new direction of treating the disease. Yes PVT1 downregulation inhibited TC cells from malignantly proliferating and invading, and promoted their apoptosis. 33408513 PVT1 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues and cells Interaction(miR-384) RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay circPVT1 expression was associated with clinical stage and lymph node metastasis. Moreover, circPVT1 directly interacted with microRNA (miR)-384, as shown by bioinformatics prediction and dual luciferase and RNA pull-down assay. miR-384 inhibition partially reversed the circPVT1 knockdown-mediated inhibitory effect on proliferation, migration and invasion of thyroid cancer cells. circPVT1 expression was associated with clinical stage and lymph node metastasis. Yes Furthermore, Cell Counting Kit-8, colony formation and Transwell chamber assays demonstrated that knockdown of circPVT1 decreased proliferation, migration and invasion of thyroid cancer cells in vitro. 36185502 PVT1 LncRNA Homo sapiens Multiple Myeloma cell lines (NCI-H929, U-266 and LP-1 cell lines) regulation[miR-486-mediated CDK4 and BCAS2 ] CCK8//qRT-PCR//Western Blot Lnc-Pvt1 expression was increased in MM cell lines (NCI-H929, U-266 and LP-1 cell lines) compared with human normal plasma cells.Lnc-Pvt1 knockdown inhibits cell proliferation and induces cell apoptosis through potentially regulating miR-486-mediated CDK4 and BCAS2 in MM. Yes In U-266 cells, lnc-Pvt1 shRNA suppressed cell proliferation while enhanced cell apoptosis compared with control shRNA. 31900844 PVT1 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues Regulation[TGF-β/Smad pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay We first determined that PVT1 was upregulated in pancreatic cancer tissues compared with adjacent normal tissues.These findings revealed that PVT1 acts as an oncogene in pancreatic cancer, possibly through the regulation of EMT via the TGF‑β/Smad pathway and PVT1 may serve as a potential target for diagnostics and therapeutics in pancreatic cancer. Yes Knockdown of PVT1 inhibited viability, adhesion, migration and invasion. 29845201 PVT1 LncRNA Homo sapiens Adenocarcinoma of Lung lung ADC cells regulation[miR-378c,SLC2A1 ] qRT-PCR//Wound Healing Assay//MTT//Transwell Assay The results revealed that PVT1 was highly expressed in lung ADC cells, Together, silencing PVT1 downregulated SLC2A1 expression via targeting miR-378c, and then repressed lung ADC cells growth, migration, and invasion. Yes The results revealed that PVT1 was highly expressed in lung ADC cells, and the overexpression of PVT1 promoted the proliferation, migration, and invasion of lung ADC cells. 32960438 PVT1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cell and tissues Interaction(PVT1/EIF4A3/circLMNB2) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay PVT1 and EIF4A3 were upregulated and indicated poor prognosis in LUAD. Mechanistically, PVT1 was stabilized by EIF4A3. PVT1 could recruit EIF4A3 to promote circLMNB2 expression. Rescue experiments indicated that circLMNB2 overexpression could reverse the reduced behavior caused by PVT1 or EIF4A3 knockdown. Enrichment analysis showed that PVT1/EIF4A3/circLMNB2 may regulate LUAD development by participating in ribosome biogenesis and spliceosome formation. PVT1 and EIF4A3 were upregulated and indicated poor prognosis in LUAD. Yes Knockdown of PVT1 and EIF4A3 suppressed LUAD cell proliferation, migration, invasion, and EMT. 35435126 PVT1 LncRNA Homo sapiens Gallbladder Neoplasms GBC tissues and cell lines Regulation[miR-143/HK2 axis] Wound Healing Assay//qPCR//CCK8//RIP//IHC//EdU Staining//Transwell Assay PVT1 was upregulated in GBC tissues and cells and was positively associated with malignancies and worse overall survival. Further studies demonstrated that PVT1 positively regulated HK2 expression via its competing endogenous RNA (ceRNA) activity on miR-143. Additionally, HK2 expression and function were positively correlated with PVT1. Furthermore, we observed that the PVT1/miR-143/HK2 axis promoted cell proliferation and metastasis by regulating aerobic glucose metabolism in GBC cells. PVT1 was upregulated in GBC tissues and cells and was positively associated with malignancies and worse overall survival. Yes PVT1 knockdown inhibited cell proliferation, migration, and invasion in vitro and restrained tumor growth in vivo. 30825877 PVT1 LncRNA Homo sapiens Gallbladder Neoplasms GBC tissues and cell lines regulation[ miR-30d-5p] CCK8//qRT-PCR//Transwell Assay In GBC tissues and cell lines, upregulation of PVT1 and downregulation of miR-30d-5p were observed. These data demonstrated that PVT1 facilitated to GBC tumorigenesis by promoting cell proliferation and invasion via miR-30d-5p, indicating that PVT1 may be a potential biomarker of GBC diagnosis and treatment. Yes PVT1 silencing suppressed cell proliferation and invasion of GBC cells. 32689767 PVT1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues regulation[NOP2] qRT-PCR//Transwell Assay In this study, we reported that the long noncoding RNA-PVT1 was upregulated in PCa metastasis tissues and promoted migration of PCa cells in vitro and their metastasis in vivo. Taken together, our results show that PVT1 acts as an inducer of PCa metastasis via targeting miRNAs, thereby promoting NOP2. This axis may have diagnostic and therapeutic potential for advanced PCa. Yes In this study, we reported that the long noncoding RNA-PVT1 was upregulated in PCa metastasis tissues and promoted migration of PCa cells in vitro and their metastasis in vivo. 32764963 PVT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[miR-29c/VEGF signaling pathway] qRT-PCR//ELISA//Luciferase Report Assay//Western Blot Our results showed that higher PVT1 was expressed in NSCLC and the elevated PVT1 was closely related to angiogenesis and poor prognosis in NSCLC. We found that PVT1 promotes angiogenesis through targeting the miR-29c/VEGF signaling pathway in NSCLC. Yes Further functional analysis showed that higher PVT1 expression could promote angiogenesis by regulating VEGF in NSCLC. 31326971 PVT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues and cells regulation[miR-361-3p/SOX9 axis,Wnt/β-catenin signaling pathway] Flow Cytometry//qRT-PCR//RIP//MTT//Transwell Assay PVT1 and SOX9 was highly expressed in NSCLC tumor tissues and cells. PVT1 modulate the Wnt/β-catenin Signaling Pathway by miR-361-3p/SOX9 axis. Yes PVT1 facilitated proliferation, migration, invasion and hindered apoptosis of NSCLC cells. 32197208 PVT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell lines Interaction(miR-497) In Vivo Experiment//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//cell invasion assay Our findings indicated that PVT1 was significantly upregulated and miR-497 was markedly downregulated in NSCLC cell lines. si-PVT1 effectively decreased the expression of PVT1 and increased the expression of miR-497.RIP and luciferase reporter assay demonstrated that PVT1 could directly interact with miR-497. Moreover, PVT1 overexpression reversed the inhibitory effect of miR-497 on cell viability, invasion and promotion effect on apoptosis of NSCLC cells. Furthermore, in vivo experiment showed that knockdown of PVT1 inhibited tumor growth in vivo and promoted miR-497 expression. Yes PVT1 knockdown remarkably inhibited cell viability, invasion and promoted apoptosis in NSCLC cells. 29133127 PVT1 LncRNA Homo sapiens esophageal carcinoma EC tissues Interaction[microRNA-145-mediated ] RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Microarray//Transwell Assay We then proceeded to examine interaction among lncRNA PVT1, FSCN1, and miR-145. The effect of lncRNA PVT1 on viability, migration, invasion, apoptosis, and tumorigenesis of transfected cells was examined with gain-of-function and loss-of-function experiments. We observed that lncRNA PVT1 was robustly induced in EC. lncRNA PVT1 could bind to miR-145 and regulate its expression, and FSCN1 is a target gene of miR-145. Overexpression of miR-145 or silencing of lncRNA PVT1 was revealed to suppress cell viability, migration, and invasion abilities, while also stimulating cell apoptosis. Furthermore, our in vivo results showed that overexpression of miR-145 or silencing of lncRNA PVT1 resulted in decreased tumor growth in nude mice. In conclusion, our research reveals that down-regulation of lncRNA PVT1 could potentially promote expression of miR-145 to repress cell migration and invasion, and promote cell apoptosis through the inhibition of FSCN1. Yes Furthermore, our in vivo results showed that overexpression of miR-145 or silencing of lncRNA PVT1 resulted in decreased tumor growth in nude mice. In conclusion, our research reveals that down-regulation of lncRNA PVT1 could potentially promote expression of miR-145 to repress cell migration and invasion, and promote cell apoptosis through the inhibition of FSCN1. 31369196 PVT1 LncRNA Homo sapiens Cholangiocarcinoma CCA cells regulation[SOX2,miR-186] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay MiR-186 was poorly expressed while SOX2, lncRNA PVT1 and SEMA4D were highly expressed in CCA cells. All in all, SOX2 down-regulated miR-186 through the transcriptional activation of lncRNA PVT1, whereas elevating SEMA4D expression, thus promoting the progression of CCA. Yes The overexpression of lncRNA PVT1 and SEMA4D, as well as the inhibition of miR-186 led to elevated CCA cell proliferation, migration and invasion. In vivo experiments confirmed the inhibitory role of lncRNA PVT1 knockdown or SEMA4D knockdown in CCA. 32812642 PVT1 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cell lines Interaction(miR186/KLF5 Axis) Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Additionally, lncRNA PVT1 and KLF5 were proved to be highly expressed in CCA tissues and cell lines. Silencing of lncRNA PVT1 increased the expression of miR186, and silencing of miR186 increased the expression of KLF5 in CCA cell lines. Yes Silencing and overexpressing of lncRNA PVT1 or KLF5 markedly inhibited or increased the cell proliferation and cell invasion in CCA cell lines, respectively. Silencing and overexpressing of lncRNA PVT1 significantly inhibited and increased the expression of KLF5 in CCA cell lines, respectively. 34337058 PVT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues,cell lines Interaction[miR-519d-3p] qRT-PCR//MTT//Luciferase Report Assay PVT1 was significantly overexpressed in human LSCC tissues and several LSCC cell lines.Further bioinformatic analysis and dual-luciferase reporter assay revealed that PVT1 could function as an oncogenic transcript partly through sponging miR-519d-3p. Besides, mechanistic investigations indicated that PVT1 could promote cell and migration through interacting with miR-519d-3p. Yes Upregulation of lncRNA PVT1 markedly facilitated proliferation suppressed apoptosis and promoted cell migration in LSCC cells. We further demonstrated that silencing PVT1 strikingly suppressed proliferation, promoted apoptosis, and reduced migration in LSCC cells. 30304557 PVT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC cell lines Interaction(miR-1301-3p/MBNL1 Axis) qRT-PCR//ChIP//Colony Formation Assay//Western Blot By conducting multiple experiments, our results showed that lncRNA PVT1 was upregulated in LSCC cell lines and regulated LSCC cell proliferation, apoptosis, and its cell susceptibility to natural killer (NK) cells. Moreover, it was found that lncRNA PVT1 promotes MBNL1 expression to regulate LSCC cellular progression through sponging miR-1301-3p. Yes By conducting multiple experiments, our results showed that lncRNA PVT1 was upregulated in LSCC cell lines and regulated LSCC cell proliferation, apoptosis, and its cell susceptibility to natural killer (NK) cells. 34805417 PVT1 LncRNA Homo sapiens Adenocarcinoma Of Esophagus EAC tissues Interaction[YAP1] qRT-PCR PVT1 expression was up-regulated in EACs compared with paired BEs, and normal esophageal tissues. Mechanistically, we discovered mutual regulation of PVT1 and YAP1 in EAC cells. Inhibition of PVT1 by PVT1 ASOs suppressed YAP1 expression through increased phosphor-LATS1and phosphor-YAP1 while knockout of YAP1 in EAC cells significantly suppressed PVT1 levels indicating a positive regulation of PVT1 by YAP1. Most importantly, we found that targeting both PVT1 and YAP1 using their specific ASOs led to better antitumor activity in vitro and in vivo. + High expression of PVT1 was associated with poor differentiation, lymph node metastases, and shorter survival. Yes Effective knockdown of PVT1 in EAC cells using PVT1 ASOs resulted in decreased cell proliferation, invasion, colony formation, tumor sphere formation, and reduced proportion of ALDH1A1 cells. 31601234 PVT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung regulation[ PVT1/miR-760/IL-6] RNA Pull-Down//qRT-PCR//Luciferase Report Assay//migration assay//cell invasion assay Plasmacytoma variant translocation 1 (PVT1) has been proven to be overexpressed in NSCLC. In conclusion, a new mechanism was revealed, wherein PVT1 regulates NSCLC cell migration and invasion via miR-760/IL-6, suggesting PVT1/miR-760/IL-6 as promising prognostic biomarkers and therapeutic targets for NSCLC metastasis. Yes Here, we verified that the knockdown of PVT1 inhibited NSCLC cell migration and invasion, and that its inhibitory role on A549 cells and H1299 cells was antagonized by interleukin-6 (IL-6) treatment. 32866660 PVT1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues Interaction[downregulation of miR-16-5p] Western Blot//qRT-PCR//MTT//ELISA//Transwell Assay We found that PVT1 was upregulated in RCC tissues compared with the adjacent normal tissues. Furthermore, bioinformatic analysis and luciferase reporter assay confirmed that miR-16-5p was a target of PVT1. Silencing of miR-16-5p mostly reversed the regulatory effects on RCC cells induced by downregulation of PVT1. PVT1 expression was closely correlated with TNM stage, Fuhrman grade, lymph node metastasis and tumor size. Kaplan-Meier analysis revealed that high expression of PVT1 was significantly associated with poor overall survival. Yes Silencing of PVT1 significantly repressed cell viability, induced apoptosis and inhibited cell migration and invasion in vitro. 31040699 PTK2 CircRNA Homo sapiens stomach carcinoma GC tissues and cells Interaction(miR-139-3p) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis High expression of circPTK2 was presented in GC tissues and cells. In mechanism, circPTK2 served as a sponge of miR-139-3p. Inhibition of miR-139-3p could reverse circPTK2 silence-mediated effects on GC cell proliferation and apoptosis. Yes The circPTK2 knockdown notably suppressed cell proliferation and promoted cell apoptosis in GC. Furthermore, the xenograft tumor model was established to investigate the role of circPTK2 in GC tumor growth. 32504353 PTTG3P LncRNA Homo sapiens Asthma peripheral blood of asthmatic children Interaction(miR-192-3p/CCNB1 axis ) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Microarray//Transwell Assay PTTG3P was highly expressed in the peripheral blood of asthmatic children. PTTG3P promoted progression of childhood asthma by targeting the miR-192-3p/CCNB1 axis. Yes Knocking down PTTG3P inhibited epithelial-mesenchymal transition, proliferation, and migration of 16HBE cells. 34717195 PTPRM CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung human adenocarcinoma tissue samples and cells Interaction(miR-139-5p/SETD5 Axis) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//PCR//Transwell Assay//IF Through bioinformatics software, we found that circPTPRM was negatively correlated with mir-139-5p, and then we used human adenocarcinoma tissue samples to further verify their relationship and get the same result. Next, we used Starbase v2.0 to identify the target site of miR-139-5p and focused on SET domain containing 5 (SETD5). We derive the hypothesis by verifying the relationship between miR-139-5p and SETD5 that circPTPRM may interact with miR-139-5p/SETD5 axis. At last, we evaluated the effects of circPTPRM, SETD5, and miR-139-5p on tumor growth in vivo using BALB/c nude mice to prove the hypothesis. Yes EdU method, transwell method, and luciferase assay, RNA pull-down assay were applied, and the results show that the knockdown of circPTPRM inhibit proliferation, migration, and invasion of cells can be reversed by mir-139-5p inhibitor. 35491723 PTPRG-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cells Interaction(miR-599/PDK1 axis) qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP PTPRG-AS1 regulated pyruvate dehydrogenase kinase 1 (PDK1) expression via sponging miR-599. The PTPRG-AS1/miR-599/PDK1 axis was further verified to aggravate the progression of ESCC cells. Yes PTPRG-AS1 silencing hindered the proliferation, migration, glycolysis and stemness of ESCC cells. 34676588 PTPRG-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction( miR-199a-3p) qRT-PCR PTPRG-AS1 was upregulated in HCC tissues compared with adjacent normal tissues. Furthermore, PTPRG-AS1 served as a miR-199a-3p sponge and positively regulated YWHAG expression. Besides, PTPRG-AS1 could promote HCC through miR-199a-3p/YWHAG axis. Yes Downregulation of PTPRG-AS1 suppressed HCC progression, while overexpression of PTPRG-AS1 showed the opposite effects. 34876904 PTPRG-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma cells and tissues Expression(highly expressed) qRT-PCR//Transwell Assay The results demonstrated that PTPRG-AS1 was highly expressed in osteosarcoma cells and tissues, which was compared with normal bone cells and adjacent healthy tissues. Furthermore, PTPRG-AS1 expression level in patients with osteosarcoma and lymph node metastasis or distal metastasis was elevated compared with normal tissues. In addition, the results from univariate and multivariate analyses demonstrated that PTPRG-AS1 expression level was significantly associated with Tumor-Node-Metastasis stage (P=0.025), lymph node metastasis (P=0.035) and distant metastasis (P=0.016) in patients with osteosarcoma. Yes In addition, PTPRG-AS1 knockdown using small interfering RNA significantly decreased the invasive and migratory abilities of osteosarcoma cells in vitro. 33907574 PTPRG LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cell lines Regulation(miR-124-3p/CCND1 axis.) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining PTPRG-AS1 expression was notably high in LUAD cell lines. PTPRG-AS1 knockdown suppressed cell proliferation and cycle as well as the level of CCND1. Moreover, miR-124-3p was the mutual target of PTPRG-AS1 and CCND1. In addition, PTPRG-AS1 sponged miR-124-3p to upregulate CCND1 in LUAD cells. Moreover, miR-124-3p depletion reversed the suppression of PTPRG-AS1 silence on LUAD cell behaviors, but then CCND1 knockdown countervailed the promoting influence of downregulated miR-124-3p. Yes PTPRG-AS1 knockdown suppressed cell proliferation and cycle as well as the level of CCND1 34767727 PTPRA CircRNA Homo sapiens Atherosclerosis serum of patients with AS and in ox-LDL-treated HUVECs. Interaction(miR-671-5p) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//ELISA The results indicated that circRNA-PTPRA expression was significantly increased and miR-671-5p expression was decreased in the serum of patients with AS and in ox-LDL-treated HUVECs. In conclusion, circRNA-PTPRA downregulation protects against ox-LDL-induced HUVECs injury by upregulating miR-671-5p, thereby providing potential therapeutic targets for AS. Yes In HUVECs, downregulation of circRNA-PTPRA reversed ox-LDL-induced reduction in cell viability, increase in apoptosis, and enhanced inflammation, whereas all these effects mediated by circRNA-PTPRA downregulation in ox-LDL-treated HUVECs were abolished by miR-671-5p downregulation. 35817886 Ptn-dt LncRNA Mus musculus Carcinoma, Hepatocellular liver tissues Regulation[HuR/miR-96/Alk pathway and Ptn-Alk axis] Other From the microarray data analysis, we identified lncRNA Ptn-dt as a possible oncofetal gene. RNA pulldown assay showed that Ptn-dt could interact with the HuR protein. Interestingly, miR-96 binds with HuR to maintain its stability as well. Overexpression of lncRNA Ptn-dt led to the downregulation of miR-96, which might be due to the interaction between Ptn-dt and HuR. In our study, we found that overexpression of Ptn-dt could promote the expression of Alk through repressing miR-96 via interacting with HuR, thus enhancing the biologic function of Ptn. In summary, a new oncofetal lncRNA Ptn-dt is identified, and it can promote the proliferation of HCC cells by regulating the HuR/miR-96/Alk pathway and Ptn-Alk axis. Yes Both in vitro and in vivo experiments results confirmed that overexpression of Ptn-dt significantly promoted the proliferation of mouse HCC cells. Meanwhile, previous studies have reported that Ptn can promote tumor growth and vascular abnormalization via anaplastic lymphoma kinase (Alk) signaling. 30643194 PTK2 CircRNA Homo sapiens Non-alcoholic Fatty Liver Disease NAFLD tissues and cells Interaction(miR-200c/SIK2/PI3K/Akt axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//IHC Circ PTK2 and SIK2 were downregulated and miR-200c was upregulated in NAFLD. Upregulation of circ PTK2 reversed lipid accumulation in FFA-treated HepG2 cells. Moreover, circ PTK2 bound to miR-200c, and SIK2 was identified as the direct target of miR-200c. Circ PTK2 overexpression alleviates NAFLD development via the miR-200c/SIK2/PI3K/Akt axis. Yes Moreover, the miR-200c inhibitor-induced decrease in lipid accumulation was reversed by SIK2 knockdown. Furthermore, the impact of circ PTK2 overexpression on PI3K/Akt signaling was partially reversed by SIK2 silencing. 35791807 PVT1 LncRNA Homo sapiens Fractures, Bone 80 cases with fragility fracture, serum samples Interaction(microRNA-497-5p/HMGA2 axis) Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay It was found that the level of PVT1 increased gradually, while miR-497-5p showed a downward trend over time in both intra-articular and hand fracture patients, and the changes reached a significant level at 21 day after treatment. It was concluded that LncRNA PVT1 silencing may enhance fracture healing via mediating miR-497-5p/HMGA2 axis. Yes In vitro experiments demonstrated that PVT1 knockdown promoted cell proliferation and inhibited cell apoptosis in HFOB1.19 cells. LncRNA PVT1 acts as a competing endogenous RNA (ceRNA) of miR-497-5p, and the influence of PVT1 knockdown on HFOB1.19 cell proliferation and apoptosis was reversed by miR-497-5p inhibition. HMGA2 is the target gene of miR-497-5p. 34592894 Ptgs2 LncRNA Mus musculus Osteoarthritis cartilage tissues of the OA mouse model Interaction(miR-150/Wnt/β-catenin pathway ) qRT-PCR//Western Blot High levels of lincRNA-Cox2 were observed in cartilage tissues of the OA mouse model in vivo. In the in vitro experiments, the expression of lincRNA-Cox2 was increased in IL-1β-treated chondrocytes. Mechanistically, lincRNA-Cox2 was found to directly target miR-150, acting as a competing endogenous RNA, and the effect of si-Cox2 on the proliferation and apoptosis of chondrocytes was reversed by miR-150 inhibitors. Moreover, lincRNA-Cox2 activated the Wnt/β-catenin pathway to regulate chondrocyte proliferation and apoptosis. Yes Knockdown of lincRNA-Cox2 promoted the proliferation and inhibited the apoptosis of chondrocytes. 34093756 Ptgs2 LncRNA Mus musculus Status Epilepticus SE mice Regulation(NF-κB signaling) Western Blot//qRT-PCR//H&E Staining//ELISA//IHC//IF Moreover, activation of glial cells, NF-κB signaling and lncRNA-COX2 were significantly decreased in SE mice. In the GBE-treated SE mice with lncRNA-COX2 overexpression, NF-κB signaling was up-regulated again; the reduced level of inflammation factors was reversed; the GBE-rescued spontaneous alternation rate of Y-maze was eliminated. Yes Moreover, activation of glial cells, NF-κB signaling and lncRNA-COX2 were significantly decreased in SE mice. In the GBE-treated SE mice with lncRNA-COX2 overexpression, NF-κB signaling was up-regulated again; the reduced level of inflammation factors was reversed; the GBE-rescued spontaneous alternation rate of Y-maze was eliminated. 36419341 PTENP1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC cells Interaction(miR-17/SCARA5 axis) qRT-PCR//RNA Pull-Down We showed exosomal lncRNA PTENP1 can be delivered into and suppress the malignant phenotypes of BC cells. LncRNA PTENP1 was identified as a sponge of miR-17, and SCARA5 was identified as a target gene of miR-17. Yes We showed exosomal lncRNA PTENP1 can be delivered into and suppress the malignant phenotypes of BC cells. 35998226 PTENP1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay In this research, PTENP1 was pronouncedly downregulated in cervical cancer tissues, and low PTENP1 level was tightly linked to advanced stage and poor prognosis in cervical cancer. In this research, PTENP1 was pronouncedly downregulated in cervical cancer tissues, and low PTENP1 level was tightly linked to advanced stage and poor prognosis in cervical cancer. Yes Overexpressing PTENP1 inhibited cervical cancer progression by suppressing cell growth, motility and epithelial-to-mesenchymal transition (EMT). 32973352 PTENP1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and CC cell line regulation[miR-19b/MTUS1 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that PTENP1 was reduced in CC tissues and CC cell lines, which predicted the poor diagnosis of CC patients. Furthermore, we firstly uncovered that PTENP1 could inhibit cell proliferation and invasion via miR-19b/MTUS1 in CC patients, which uncovered the tumor-suppressive role of PTENP1 in CC and suggested that it might be a potential target for treating human CC. Yes Furthermore, PTENP1 overexpression inhibited cell proliferation ability and invasion capacity in HeLa cells, as well as repressed expressions of Cyclin D1, N-cadherin, and Vimentin. 32373949 PTENP1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells regulation[miR-106b] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay It was found that the expressions of PTENP1 and PTEN were up-regulated and that of miR-106b were down-regulated in cervical cancer tissues and cells.Our results suggest that LncRNA PTENP1 inhibits cervical cancer progression by competitively binding to miR-106b, leading to promote PTEN expression, inhibit cell proliferation and EMT and induce cell apoptosis in cervical cancer cells. Yes Over-expression of PTENP1 and miR-106b accelerated cell proliferation and slowed down cell apoptosis. 31913710 PTENP1 LncRNA Homo sapiens Glioma glioma tissues Expression[lower expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Our results showed that expression of lncRNA PTENP1 was decreased in glioma tissues when compared with normal brain tissues. Yes Overexpression of PTENP1 suppressed SHG44 and U251 cell proliferation and significantly decreased the numbers of S-phase cells. Furthermore, the invasion and migration abilities of SHG44 and U251 cells were reduced after being transfected with a PTENP1 overexpression plasmid. 30613153 PTTG3P LncRNA Homo sapiens Tongue Neoplasms tongue cancer tissues Interaction(miR-142-5p/JAG1 axis ) Transfection//Immunoblotting//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay In this study, a lncRNA PTTG3P which was upregulated in tongue cancer, was found to be positively correlated with JAG1. PPTG3P directly bound miR-142-5p, and miR-142-5p directly bound 3'UTR of JAG1 and inhibited the expression levels of JAG1. Yes In CAL-27 and SCC4 cells, PTTG3P silencing significantly decreased JAG1 proteins and the ability of tongue tumor cells to proliferate and migrate. PTTG3P overexpression exhibited the opposite effect on CAL-27 and SCC4 cells. 34952204 PTTG3P LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissue Interaction[PTTG1] Western Blot//Tunel//CCK8//qRT-PCR//Transwell Assay Here, we detected significantly higher levels of PTTG1 and PTTG3P in the resected CC tissue, compared to the paired adjacent normal cervical tissue. Our work thus suggests that PTTG3P may promote growth and metastasis of CC through PTTG1. High PTTG3P levels were associated with poor patients' survival. Yes In vitro, PTTG1 were increased by PTTG3P overexpression, but was inhibited by PTTG3P depletion in CC cells. 30853662 PTTG3P LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[sponging miR-383] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, we found that PTTG3P was up-regulated in HCC tissues and cells.Mechanistically, PTTG3P upregulated the expression of miR-383 targets Cyclin D1 (CCND1) and poly ADP-ribose polymerase 2 (PARP2) by sponging miR-383, acting as a competing endogenous RNA (ceRNA). The PTTG3P-miR-383-CCND1/PARP2 axis modulated HCC phenotypes. Moreover, PTTG3P also affected the PI3K/Akt signaling pathway. Yes Functional experiments demonstrated that knockdown of PTTG3P inhibited cell proliferation, migration and invasion, and promoted cell apoptosis, acting as an oncogene. 31340767 PTTG3P LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues Regulation[PI3K/AKT signaling] ISH//qRT-PCR//Western Blot We found that PTTG3P was frequently up-regulated in HCC and its level was positively correlated to tumor size, TNM stage and poor survival of patients with HCC.Our findings suggest that PTTG3P, a valuable marker of HCC prognosis, promotes tumor growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in HCC and might represent a potential target for gene-based therapy. We found that PTTG3P was frequently up-regulated in HCC and its level was positively correlated to tumor size, TNM stage and poor survival of patients with HCC. Yes Enforced expression of PTTG3P significantly promoted cell proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. 29803224 PVT1 LncRNA Homo sapiens Purpura, Thrombocytopenic, Idiopathic ITP patients Interaction(NOTCH1 ) Western Blot//Transfection//Flow Cytometry//qRT-PCR//ELISA PVT1 was down-regulated and Th17 cells were up-regulated in ITP patients.Besides, PVT1 could bind to NOTCH1 and mediated NOTCH1 degradation by increasing its ubiquitination. Yes Overexpression of PVT1 decreased the number of Th17 cells, and also decreased the levels of IL-17, RORγt, and NOTCH1. Additionally, excessive expression of PVT1 could increase the levels of PVT1, reduce the amount of Th17 cells, as well as the levels of IL-17, RORγt, and NOTCH1, while co-overexpressing NOTCH1 reversed the results. 34555308 PVT1 LncRNA Homo sapiens acute myeloid leukemia AML patient samples and cell Interaction( miR-29 family/WAVE1 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//EdU Staining//Transwell Assay PVT1 expression was significantly increased in AML patient samples and cells, which positively correlated with WAVE1 expression. Moreover, PVT1 acted as a sponge for miR-29 family to increase WAVE1 expression in AML cells. Overexpression of WAVE1 partly counteracted PVT1 knockdown-induced anti-tumour effects on AML cells in vitro and xenograft tumour in vivo. PVT1 facilitated the progression of AML via regulating miR-29 family/WAVE1 axis. Yes Silencing of PVT1 restrained growth, migration and invasion, while inducing apoptosis of AML cells. 33558065 PVT1 LncRNA Homo sapiens Acute Kidney Injury HK-2 cells Interaction(miR-27a-3p/OXSR1 axis) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//ELISA In the present study, reverse transcription-quantitative PCR analysis indicated that, in HK-2 cells treated with LPS, the mRNA expression levels of lncRNA PVT1 and oxidative stress responsive kinase 1 (OXSR1) were upregulated, and the expression of microRNA (miR)-27a-3p was downregulated. Dual-luciferase reporter assay, RIP assay and pull-down assay results demonstrated that miR-27a-3p may be a target miR of PVT1, and that OXSR1 is the target gene of miR-27a-3p. Yes Furthermore, LPS treatment could promote the secretion of tumor necrosis factor (TNF)-α and interleukin (IL)-6, inhibit cell proliferation and induce apoptosis, which was rescued by PVT1 knockdown. 35978931 PVT1 LncRNA Homo sapiens Mesothelioma ACC‑MESO‑1, ACC‑MESO‑4, CRL‑5915, and CRL‑5946 mesothelioma cell lines Regulation(FOXM1) cell invasion assay//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Cell Proliferation Assay//Cell Cycle Assay Increased PVT1 expression was identified in ACC‑MESO‑1, ACC‑MESO‑4, CRL‑5915, and CRL‑5946 mesothelioma cell lines. The results of reverse transcription‑quantitative polymerase chain reaction analysis revealed that PVT1 knockdown in mesothelioma cell lines caused the downregulation of Forkhead box M1 (FOXM1) expression, while the results of western blot analysis revealed that this knockdown reduced FOXM1 expression at the protein level. Yes Knockdown of PVT1 expression in these cell lines by small interfering RNA transfection resulted in decreased cell proliferation and migration and increased the proportion of cells in the G2/M phase. 34859258 PVT1 LncRNA Homo sapiens Ischemic Stroke PC12 cells Interaction(miR-214/Gpx1 axis) Western Blot//Transfection//qRT-PCR//RIP//MTT//Luciferase Report Assay//ELISA Results showed that PVT1 was increased significantly in OGDR PC12 cells.More importantly, PVT1 or Gpx1 was a target of miR-214. Mechanistically, PVT1 acted as a competing endogenous RNA of miR-214 to regulate the downstream gene Gpx1. In conclusion, PVT1 knockdown attenuated OGDR PC12 cell injury by modulating miR-214/Gpx1 axis. These findings offer a potential novel strategy for ischemic stroke therapy. Yes PVT1 knockdown significantly enhanced cell viability and attenuated cell apoptosis, ROS generation, and inflammation in OGDR PC12 cells. 35978647 PVT1 LncRNA Homo sapiens Pulpitis saliva of pulpitis patients Interaction(miR-128-3p) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay The expression of PVT1 increased, while the miR-128-3p level decreased, in the saliva of pulpitis patients. The Luciferase reporter gene verified the targeting relationship between PVT1 and miR-128-3p, and the latter was negatively regulated by PVT1. Further in-vitro studies showed that inhibition of miR-128-3p could reverse the effect of si-PVT1 on cell viability, cell apoptosis and inflammatory response. ROC curves showed that both PVT1 and miR-128-3p had the potential to diagnose pulpitis. Yes This in-vitro study revealed that the expression of PVT1 was increased in the pulpitis cell model. A low level of PVT1 suppressed the hDPCs injury induced by LPS. 35723715 Pvt1 LncRNA Mus musculus Cerebral Ischemia/Reperfusion Injury brain tissues of mice Interaction(miR-30c-5p/ Rock2) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//FISH//Flow Cytometry//RIP//qRT-PCR//Luciferase Report Assay PVT1 was upregulated in the brain tissues of mice treated with MCAO/R and primary cerebral cortex neurons of mice treated with OGD/R. Moreover, we demonstrated that PVT1 acts as a competitive endogenous RNA (ceRNA) that competes with miR-30c-5p, thereby negatively regulating its endogenous target Rock2. Yes Mechanistically, PVT1 knockdown resulted in a lower infarct volume and ameliorated neurobehavior in MCAO mice. Consistent with in vivo results, PVT1 upregulation significantly decreased the viability and induced apoptosis of neurons cultured in OGD/R. Overexpression of miR-30c-5p significantly promoted cell proliferation and inhibited apoptosis. M 34436749 Pvt1 LncRNA Rattus norvegicus Liver Neoplasms 50 rats and liver cancer cell line HepG2 Regulation(MMP9) In Vivo Experiment//Cell Proliferation Assay The results of the study showed that after knocking down the expression of lncRNA-PVT1 in the observation group, the expression of MMP9 also decreased. At the same time, the migration rate of LCC HepG2 decreased by 27.4%, the level of invasion ability decreased by 21.6%, and the proliferation rate of LCC decreased by 17.8%. Yes The results of the study showed that after knocking down the expression of lncRNA-PVT1 in the observation group, the expression of MMP9 also decreased. At the same time, the migration rate of LCC HepG2 decreased by 27.4%, the level of invasion ability decreased by 21.6%, and the proliferation rate of LCC decreased by 17.8%. 36164442 Pvt1 LncRNA Rattus norvegicus Ischemic Stroke cerebral cortex tissues of MCAO rats Interaction(microRNA-24-3p/STAT3 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Tunel//qRT-PCR//RIP//Luciferase Report Assay//IHC//ChIP SOX2, PVT1 and STAT3 were highly expressed while miR-24-3p was poorly expressed in cerebral cortex tissues of MCAO rats. Restored miR-24-3p abolished PVT1 overexpression-induced brain injury in MCAO rats. SOX2 directly promoted PVT1 expression and further increased STAT3 by sponging miR-24-3p. Yes Depleted SOX2 or PVT1 alleviated brain injury in MCAO rats as reflected by neuronal apoptosis and oxidative stress restriction, brain water content reduction, and neurological deficit and neuron survival improvements. Overexpression of PVT1 functioned oppositely. 34521353 Pvt1 LncRNA Rattus norvegicus Non-alcoholic Fatty Liver Disease serum Interaction(miR-20a-5p) In Vivo Experiment//qRT-PCR//Luciferase Report Assay PVT1 was upregulated in NAFLD patients and mice, while miR-20a-5p was decreased. Their expression trends were similar in patients with HOMA-IR ≥2.5. What's more, miR-20a-5p, FBG, ALT, and HOMA-IR were independently correlated with PVT1. And PVT1 and miR-20a-5p show high clinical diagnostic value. Bodyweight, insulin sensitivity, lipid metabolism inductors were increased in NAFLD mice, but these increases were attenuated by PVT1 elimination. Finally, miR-20a-5p might function as the possible miRNA target of PVT1 via the binding sites at 3'-UTR and negatively regulated by it. Yes miR-20a-5p, FBG, ALT, and HOMA-IR were independently correlated with PVT1. 34848984 PURPL LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-137-ZBTB7A-PI3K-AKT-NF-κB axis) IHC//Western Blot//Flow Cytometry//qRT-PCR//FISH//IF//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our statistics revealed that PURPL presented a high expression in GC tissues and cell lines. These findings disclosed that PURPL serves as an oncogene in the context of GC via miR-137-ZBTB7A-PI3K-AKT-NF-κB axis modulation. Yes PURPL overexpression remarkably exacerbated colony formation, migration, and invasion and repressed apoptosis in GC cells (AGS and MNK-45). In-vivo experiments also corroborated that cell growth was boosted by PURPL up-regulation. 35012438 PURPL LncRNA Homo sapiens Colorectal Neoplasms CRC cell lines and clinical tissues Interaction(LINC021/IMP2/MSX1) Flow Cytometry//qRT-PCR//RNA Pull-Down Specifically, a remarkable upregulation of LINC021 was confirmed in CRC cell lines and clinical tissues (n = 130). Mechanistically, LINC021 directly recognized IMP2 protein, the latter enhanced the mRNA stability of transcripts such as MSX1 and JARID2 by recognizing their m6A-modified element RGGAC. High level of LINC021acted as an independent prognostic predictor for CRC clinical outcomes. Yes Functional assays demonstrated that LINC021 exerted its functions as an oncogene to aggravate CRC malignant phenotypes including enhanced cell proliferation, colony formation, migration capabilities, and reduced cell apoptosis. 35173309 PURPL LncRNA Homo sapiens Liver Neoplasms liver cancer tissues and cell lines Interaction[regulating p53 ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay The results revealed that PURPL was significantly upregulated in liver cancer tissues compared with in paracancerous tissues, and was associated with tumor differentiation stage and tumor size. Most importantly, PURPL expression was negatively correlated with p53 mRNA expression. In summary, lncRNA‑PURPL was proposed to promote cell proliferation in liver cancer by regulating the p53 gene. As such, it could serve as a potential therapeutic target for the diagnosis and treatment of liver cancer. The results revealed that PURPL was significantly upregulated in liver cancer tissues compared with in paracancerous tissues, and was associated with tumor differentiation stage and tumor size. PURPL was also upregulated in various liver cancer cell lines. Yes Silencing of PURPL inhibited liver cancer cells proliferation, blocked cell cycle progression, and promoted apoptosis. 31059022 PUM1 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC samples and cells Interaction(miR-340-5p/FABP7 axis) colony Formation Assay//RNA Pull-Down//TUNEL//Western Blot//Wound Healing Assay//Transfection//qPCR//Tunel//Colony Formation Assay//Flow Cytometry//RIP//PCR//IP//Transwell Assay//IF CircPUM1 was highly expressed in ccRCC samples and cells.CircPUM1 was localized in the cytoplasm and bound to miR-340-5p. Overexpression of miR-340-5p inhibited the growth of ccRCC cells. miR-340-5p targeted FABP7, and CircPUM1 induced FABP7 expression and the activation of MEK/ERK pathway through competitively binding to miR-340-5p. Overall, CircPUM1 upregulates FABP7 expression by competitively binding to miR-340-5p, and then activates the MEK/ERK pathway, thus promoting ccRCC progression. Yes Inhibition of CircPUM1 prevented the growth ccRCC cells. 33472512 PTTG3P LncRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues regulation[PTTG3P/microRNA-155-5P ] qRT-PCR//Luciferase Report Assay qRT-PCR results showed that LncRNA PTTG3P was markedly up-regulated in CRC tumor tissues than that in adjacent tissues. Therefore, dissecting the aberrant regulation of LncRNA PTTG3P/microRNA-155-5P may be valuable for early screening, guidance treatment, and recurrence detection of CRC. Meanwhile, patients with high LncRNA PTTG3P expression had higher rates of lymph node metastasis and distant metastasis. Yes In addition, cell functional experiments suggested that knocking down PTTG3P markedly reduced the migration abilities of CRC cells. 32606747 PTTG3P LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(METTL3/PTTG3P/YAP1 axis ) qRT-PCR//EdU Staining PTTG3P was upregulated in CRC tissues and was closely correlated with unsatisfactory prognosis. Mechanistically, the N6-methyladenosine (m6A) subunit METTL3 increased PTTG3P expression by influencing its stability, while insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) could identify PTTG3P m6A methylation status and bind to it. IGF2BP2 knockdown partly recovered PTTG3P expression induced by METTL3, indicating that METTL3-regulated PTTG3P expression depended on the presence of IGF2BP2. Finally, rescue assays validated the critical role of the METTL3/PTTG3P/YAP1 axis on CRC proliferation. PTTG3P was upregulated in CRC tissues and was closely correlated with unsatisfactory prognosis. Yes PTTG3P facilitated glycolysis and proliferation, and the transcriptional regulator YAP1 was necessary for PTTG3P-induced proliferation. 34660259 SNHG3 LncRNA Homo sapiens Uterine Cervical Neoplasms CC patients Interaction(oncoprotein YAP1) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//qRT-PCR//RIP//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay Upregulation of SNHG3 expression was associated with advanced FIGO stage and metastasis, and indicated poor overall survival of the CC patients. Functionally, SNHG3 enhanced the proliferation, migration and invasion of CC cells in vitro, and facilitated CC growth in vivo. Further investigation uncovered that SNHG3 interacted with oncoprotein YAP1, thus suppressing its degradation. Upregulation of SNHG3 expression was associated with advanced FIGO stage and metastasis, and indicated poor overall survival of the CC patients. Yes  Functionally, SNHG3 enhanced the proliferation, migration and invasion of CC cells in vitro, and facilitated CC growth in vivo. 34816392 SNHG3 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow Regulation[miR-758-3p/SRGN axis] qRT-PCR Likewise, serglycin (SRGN), which plays an important role in granule-mediated apoptosis, was previously verified to be upregulated in AML and confirmed again by the present study, and its upregulation predicted poor outcomes in AML. Besides, silencing SNHG3 noticeably decreased the expression of SRGN in AML cells. Moreover, we uncovered that SNHG3 modulated SRGN expression by competitively binding with miR-758-3p. Importantly, both miR-758-3p suppression and SRGN overexpression could mitigate the inhibitory effects of SNHG3 depletion on AML cell growth. Intriguingly, the higher SRGN expression in AML samples with a higher SNHG3 level exhibited an enhanced Ki67 level but a reduced caspase 3 level. To sum up, SNHG3 elicits a growth-promoting function in AML via sponging miR-758-3p to regulate SRGN expression, providing a new therapeutic road for AML patients. Yes Furthermore, knockdown of SNHG3 or SRGN inhibited cell proliferation and induced cell apoptosis. 31452272 OIP5-AS1 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues regulation[OIP5-AS1/miR-137/ZNF217 Axis] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay We found that OIP5-AS1 was significantly overexpressed in EOC. OIP5-AS1 regulated ovarian cancer progression via modulating miR-137/ZNF217 signaling, suggesting that targeting OIP5-AS1 could be conducive to EOC clinical treatment. Yes Knockdown of OIP5-AS1 inhibited cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process, yet facilitated apoptosis in vitro. 32801903 hsa_circ_0008732 CircRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines Interaction(microRNA-223-3p/ FBXW7 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Transwell Assay Circ-BNC2 expression was downregulated in OC tissues and cell lines, which was associated with higher FIGO stage and lymph node metastasis of OC patients. Circ-BNC2 overexpression repressed the proliferation, migration, invasion of OC cells and induced cell cycle arrest, while silencing circ-BNC2 worked oppositely. Mechanistically, circ-BNC2 could upregulate FBXW7 expression in OC cells via sponging miR-223-3p. Circ-BNC2 expression was downregulated in OC tissues and cell lines, which was associated with higher FIGO stage and lymph node metastasis of OC patients. Yes Circ-BNC2 overexpression repressed the proliferation, migration, invasion of OC cells and induced cell cycle arrest, while silencing circ-BNC2 worked oppositely. Mechanistically, circ-BNC2 could upregulate FBXW7 expression in OC cells via sponging miR-223-3p. 35965327 circPLK1 CircRNA Homo sapiens Mesothelioma, Malignant MPM tumor tissues and cell lines Interaction(miR-1294/HMGA1 Pathway) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Bioinformatics Analysis//Transfection//qPCR//CCK8//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay CircPLK1 was upregulated in MPM tumor tissues and cell lines. CircPLK1 contained a binding site for miR-1294 and thus bound to miR-1294 to sequester its expression. Inhibition of miR-1294 reversed the effects of circPLK1 knockdown. HMGA1 was a target of miR-1294, and circPLK1 bound to miR-1294 to increase the expression of HMGA1. MiR-1294 restoration also suppressed the proliferation, migration, invasion and stemness of MPM cells, while these effects were abolished by HMGA1 overexpression. Yes CircPLK1 knockdown suppressed the proliferation, migration, invasion and stemness of MPM cells. In addition, circPLK1 knockdown inhibited tumor growth in vivo. 35050425 UCA1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues interaction[targeting miR-155] qRT-PCR//Luciferase Report Assay UCA1 level was elevated and miR-155 was reduced in cervical cancer tissues with significant differences compared to adjacent tissues (p <0.05). UCA1 expression in cervical cancer is increased and related to patient survival and miR-155 expression is reduced. Lnc-RNA UCA1 regulates EMT occurrence in cervical cancer cells by targeting miR-155. Patients with high UCA1 level showed short survival time (p <0.05). Yes Down-regulation of UCA1 can significantly inhibit cell proliferation, migration and invasion. 33090390 UCA1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines regulation[miR-204/KIF20A axis] qRT-PCR//Western Blot We found that UCA1 expression was greatly up-regulated in cervical cancer tissues and cell lines.Our results identified that UCA1 could serve as an oncogene in cervical cancer cell progression through the modulating of miR-204/KIF20A axis. Yes Our in vitro assays revealed that the suppressing of UCA1 could reduce cervical cancer cells proliferation, migration, and invasion. 32835591 UCA1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues interaction[ targeting miR-145] qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay LncRNA UCA1 expression was significantly increased in cervical cancer and miR-145 expression was decreased compared with the normal group (p<0.05). LncRNA UCA1 expression is significantly increased in cervical cancer and miR-145 expression is decreased with a negative correlation between them. Yes The downregulation of UCA1 significantly inhibited tumor cell proliferation, migration, and invasion compared with NC group (p<0.05). 32329829 UCA1 LncRNA Homo sapiens Uterine Cervical Neoplasms CaSki-Exo Interaction(microRNA-122-5p/SOX2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//Flow Cytometry//qRT-PCR//CCK8//FISH//Luciferase Report Assay//Invasion Assay Up-regulated UCA1 and SOX2 and down-regulated miR-122-5p were found in CaSki-Exo.Silencing UCA1 or up-regulating miR-122-5p degraded SOX2 expression, and reduced invasion, migration and proliferation of CD133+CaSki cells while advanced apoptosis and suppressed the tumor volume and weight in nude mice. Yes Silencing UCA1 or up-regulating miR-122-5p degraded SOX2 expression, and reduced invasion, migration and proliferation of CD133+CaSki cells while advanced apoptosis and suppressed the tumor volume and weight in nude mice. 34053467 UCA1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Interaction(microRNA-299-3p) Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay The results demonstrated that UCA1 expression was upregulated in cervical cancer tissues and cell lines.Notably, UCA1 interacted with miR-299-3p and negatively regulated miR-299-3p expression. In addition, miR-299-3p expression was downregulated in cervical cancer tissues and cell lines. Overexpression of miR-299-3p suppressed the proliferation and invasion of cervical cancer cells, reversing the effects of UCA1 knockdown on cervical cancer cell proliferation. Yes Furthermore, overexpression of UCA1 enhanced the proliferation and invasion of cervical cancer cells, the effects of which were reversed following UCA1 knockdown. 34589151 circHMGB2 CircRNA Homo sapiens Adenocarcinoma of Lung NSCLC tissues Interaction(miR-181a-5p/CARM1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Transfection//Colony Formation Assay//CCK8//qRT-PCR//FISH//RIP//Flow Cytometry//Luciferase Report Assay//IHC//Transwell Assay The expression of circHMGB2 (hsa_circ_0071452) was significantly upregulated in NSCLC tissues, and survival analysis identified circHMGB2 as an independent indicator of poor prognosis in the LUAD and LUSC patients. Mechanistically, circHMGB2 relieves the inhibition of downstream CARM1 by sponging miR-181a-5p, thus inactivating the type 1 interferon response in the LUAD and LUSC. Moreover, we found that the upregulation of circHMGB2 expression decreased the efficacy of anti-PD-1 therapy, and we revealed that the combination of the CARM1 inhibitor EZM2302 and an anti-PD-1 antibody exerted promising synergistic effects in a preclinical model. The expression of circHMGB2 (hsa_circ_0071452) was significantly upregulated in NSCLC tissues, and survival analysis identified circHMGB2 as an independent indicator of poor prognosis in the LUAD and LUSC patients. Yes We found that circHMGB2 exerted a mild effect on the proliferation of the LUAD and LUSC cells, but circHMGB2 substantially reshaped the tumor microenvironment by contributing to the exhaustion of antitumor immunity in an immunocompetent mouse model and a humanized mouse model. 35525959 UCA1 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction[ sponging miR-135a] CCK8//qRT-PCR//Transwell Assay//Western Blot lncRNA UCA1 was highly expressed in glioma tissues and cell lines. In conclusion, lncRNA UCA1 can induce the activation of HOXD9 by inhibiting the expression of miR-135a and promote the occurrence of EMT in glioma. lncRNA UCA1 expression was associated with significantly poor overall survival in gliomas. Yes Moreover, lncRNA UCA1 significantly enhanced cell proliferation and migration, and promoted the occurrence of EMT. 31680311 UCA1 LncRNA Homo sapiens Glioma glioma tissues Regulation[Wnt/β-catenin signaling pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Cell Apoptosis Assay//cell invasion assay UCA1 was found to be highly up-regulated in glioma cells,Taken together, our results showed that UCA1 had a functional role in the regulation of glioma cell growth, invasion and migration, and chemo-resistance possibly via Wnt/β-catenin signaling pathway. Yes UCA1 was found to be highly up-regulated in glioma cells, and knock-down of UCA1 inhibited cell growth, invasion and migration, and also induced apoptosis in glioma cells. On the other hand, overexpression of UCA1 promoted cell proliferation, cell invasion and migration in glioma cells. 31596734 UCA1 LncRNA Homo sapiens Esophageal Neoplasms EC tissues and cells Interaction[decreasing ZEB2 expression] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay There were overly expressed UCA1 and ZEB2 and lowly expressed miR-498 in EC tissues and cells. Yes With down-regulated UCA1 and up-regulated miR-498, ZEB2 expression, cell proliferation, colony formation, invasion, migration ability, EMT, tumor growth rate and weight in nude mice were apparently reduced. 31387451 circSTX6 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues Regulation(circSTX6/miR-449b-5p axis and circSTX6/CUL2/HIF1A signaling pathway) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//CCK8//qRT-PCR//RIP//FISH//RNA-seq//Luciferase Report Assay//Microarray//Colony Formation Assay//ChIP Our findings indicate that circSTX6 facilitates proliferation and metastasis of PDAC cells by regulating the expression of MYH9 through the circSTX6/miR-449b-5p axis and circSTX6/CUL2/HIF1A signaling pathway. Therefore, circSTX6 could serve as a potential therapeutic target for the treatment of PDAC. Furthermore, circSTX6 expression was associated with tumor differentiation and N stage. Yes Our findings indicate that circSTX6 facilitates proliferation and metastasis of PDAC cells by regulating the expression of MYH9 through the circSTX6/miR-449b-5p axis and circSTX6/CUL2/HIF1A signaling pathway. Therefore, circSTX6 could serve as a potential therapeutic target for the treatment of PDAC. 35650603 UCA1 LncRNA Homo sapiens Glioma glioma tissue and cells Interaction(miR-122) Transfection//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay " The results demonstrated that UCA1 was upregulated in glioma tissue and indicated a poor prognosis.Bioinformatics analysis and luciferase reporter assay verified the complementary binding within UCA1 and miR-122 at the 3'-UTR. Functional experiments revealed that UCA1 acted as an miR-122 ""sponge"" to modulate glioma cell proliferation, migration, and invasion via downregulation of miR-122. " The results demonstrated that UCA1 was upregulated in glioma tissue and indicated a poor prognosis. Yes UCA1 knockdown induced by si-UCA1 significantly suppressed the proliferative, migrative, and invasive activities of glioma cell lines (U87 and U251). 28548636 UCA1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC cell lines Regulation[miR-145] Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Our study confirmed that UCA1 was upregulated in NPC cell lines and involved in NPC tumorigenesis according to our established UCA1-associated competing endogenous RNA network. LncRNA UCA1 functions as a tumor promoter in NPC. UCA1 promotes the proliferation and invasion of NPC cells by sponging miR-145, functionally altering ADAM17 expression targeted by miR-145. Yes Moreover, functional analyses indicated that the downregulation of UCA1 exerted inhibitory effects on cell proliferation, invasion, and migration. 30498361 UCA1 LncRNA Homo sapiens Thyroid Neoplasms cell lines Regulation[UCA1/miR-15a axis ] CCK8//qRT-PCR//Immunoblotting UCA1 was overexpressed in pc-UCA1-transduced TPC-1 cells while down-regulated in si-UCA1-transduced TPC-1 cells compared with their corresponding control groups (Figure 1A,B). At last, the Hippo and JNK signal pathways were activated by overexpressed UCA1 but were then weakened by the adding of miR-15a. In conclusion, our study revealed UCA1/miR-15a axis implicated in thyroid cancer cells EMT, exposing a novel mechanism of thyroid cancer progression. Yes We found that overexpressed UCA1 strongly promoted cell proliferation. However, the knockdown of UCA1 suppressed cell proliferation and induced obvious cell apoptosis. 31062608 UCA1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC cell lines and tissues Regulation[miR-204-mediated BRD4 activation] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay It was demonstrated that the expression level of UCA1 was more significantly upregulated in PTC cell lines and tissues when compared with the immortal human thyroid follicular cell line and adjacent normal tissues, respectively.The results of the present study illustrated that UCA1 promotes PTC progression by acting as a competing endogenous RNA by sponging miR‑204. Yes UCA1 knockdown significantly inhibited PTC cell viability, colony formation and the bromodomain containing 4 (BRD4) expression level in vitro, and retarded PTC tumor growth in vivo. 30015945 UCA1 LncRNA Homo sapiens Multiple Myeloma cell lines Interaction[miR-1271-5p/HGF axis] CCK8//qRT-PCR//Luciferase Report Assay//Flow Cytometry LncRNA UCA1 and HGF expression was higher in the cells and samples of patients with MM than in normal plasma cells. Our investigations might contribute to a better understanding of the lncRNA UCA1/miR-1271-5p/HGF axis as a potential therapeutic strategy in MM. Yes Moreover, downregulation of lncRNA UCA1 and HGF inhibited cell proliferation and facilitated cell apoptosis in RPMI 8226 cells (human MM cell line). 31356563 UCA1 LncRNA Homo sapiens Pancreatic Neoplasms cell lines Interaction[focal adhesion pathway] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Microarray//Transwell Assay It was identified that the level of urothelial cancer associated 1 (UCA1) was increased in PaC cellsThe luciferase reporter assay recognized that miR-107 was targeted by UCA1, and integrin subunit α 2 (ITGA2) was further targeted by miR-107. This confirmed the prediction of lncRNA-miRNA-mRNA regulation mechanism. In the regulatory pathways, UCA1 and ITGA2 promoted PaC progression via focal adhesion pathway related proteins such as ITGA3, SRC protooncogene/nonreceptor tyrosine kinase, protein tyrosine kinase 2, and AKT serine/threonine kinase 1. Yes It was identified that the level of urothelial cancer associated 1 (UCA1) was increased in PaC cells, and the inhibition of UCA1 suppressed migration and invasion ability of the cancer cells. 30569514 UCA1 LncRNA Homo sapiens Pancreatic Neoplasms blood regulation[miR-96-5p/AMOTL2/ERK1/2 axis] qRT-PCR In addition, the expression levels of UCA1 in exosomes derived from PC patients' serum were higher than in healthy controls and were associated with poor survival of PC patients.Collectively, these results indicate that hypoxic exosomal UCA1 could promote angiogenesis and tumor growth through the miR-96-5p/AMOTL2/ERK1/2 axis and therefore, serve as a novel target for PC treatment. In addition, the expression levels of UCA1 in exosomes derived from PC patients' serum were higher than in healthy controls and were associated with poor survival of PC patients. Yes Moreover, hypoxic exosomal UCA1 could promote angiogenesis and tumor growth both in vitro and in vivo. 32942233 UCA1 LncRNA Homo sapiens Esophageal Neoplasms blood Expression[lower expressed] qRT-PCR The results revealed that the expression of UCA1 was decreased in esophageal cancer tissues and plasma exosomes. Yes Overexpression of UCA1 played anticancer roles in esophageal cancer cells through inhibiting cell proliferation, invasion and migration, and colony formation. Also, exosomal UCA1 was taken up by esophageal cancer cells and inhibited the progression of esophageal cancer in vitro and tumor growth in vivo. 33122449 circNup188 CircRNA Homo sapiens Brain Ischemia OGD/R cell model Interaction(circNup188/miR-760-3p/Map3k8 axis) Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//ELISA//Bioinformatics Analysis//IF Regulating circNup188 expression could affect OGD/R cells function. In addition, miR-760-3p might play a vital role in OGD/R cell model. Moreover, circNup188 regulated cerebral ischemia by sponging miR-760-3p. miR-760-3p might be involved in inflammation in OGD/R cell model by regulating Map3k8 to activate the NF-κB pathway. Yes Regulating circNup188 expression could affect OGD/R cells function. In addition, miR-760-3p might play a vital role in OGD/R cell model. 35636640 UCA1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues,blood Regulation[Wnt/β-catenin signaling pathway] Western Blot//Migration Assay//CCK8//qRT-PCR//Invasion Assay Results indicated that the expression levels of UCA1 were significantly higher in tumor tissues compared with adjacent healthy tissues in the majority of patients with LSCC. In addition, serum levels of UCA1 were significantly higher in patients with LSCC coapred with healthy controls. The present findings suggest that UCA1 can promote cell proliferation, invasion and migration of LSCC cells by activating the Wnt/β-catenin signaling pathway. Yes UCA1 overexpression promoted, whereas UCA1 knockdown inhibited the proliferation, migration and invasion of LSCC cells. 30679991 circGMCL1 CircRNA Homo sapiens Crohn Disease experimental colitis models Interaction(miR-124-3p/ANXA7) In Vivo Experiment//qRT-PCR//Luciferase Report Assay//FISH Results showed that circGMCL1 expression was negatively correlated with CD-associated inflammatory indices, suggesting that it is a CD-associated circRNA. Microarray and bioinformatics analyses identified miR-124-3p and Annexin 7 (ANXA7) as its downstream mechanisms. Yes The in vitro studies revealed that circGMCL1 mediates its effects on autophagy and NLRP3 inflammasome-mediated pyroptosis in epithelial cells through the ceRNA network. Moreover, the in vivo studies identified the therapeutic effect of PLGA MSs-carried oe-circGMCL1 in experimental colitis models. 36088391 UCA1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues,cell lines Regulation[miR-28-5p/HOXB3 axis] qRT-PCR The results showed that UCA1 was upregulated in colon cancer tissues when compared with the adjacent nonhumorous tissues, as well as in the various colon cancer cell lines.Further mechanistic studies indicated that UCA1 knockdown played tumor suppressive roles in SW480 and HT116 cells through binding with miR-28-5p. We also, for the first time, identified HOXB3 as the target gene of miR-28-5p and that HOXB3 overexpression could mediate the functions of UCA1 in cell proliferation and migration of colon cancer cells. In conclusion, our data provided evidence for the regulatory network of UCA1/miR-28-5p/HOXB3 in colon cancer, suggesting that UCA1, miR-28-5p, and HOXB3 are the potential targets for colon cancer therapy. Furthermore, a high UCA1 level in colon cancer tissues is positively associated with the tumor size and advanced tumor stages. Yes Functional assays revealed that both UCA1 knockdown and miR-28-5p overexpression could inhibit colon cancer cell growth and migration. 30652355 UCA1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissue and cell lines Regulation[miR-204/IGFBP5 axis] qRT-PCR The results revealed that UCA1 was upregulated in PTC tissue and cell lines.Our study demonstrated that UCA1 exerts activity of oncogenes in PTC through regulating miR-204/IGFBP5 axis. Yes UCA1 knockdown significantly suppressed the cell proliferation, migration, and invasion of TPC-1 cells. 30425512 UCA1 LncRNA Homo sapiens Carcinoma, Hepatocellular Tumor tissues Expression[highly expressed] CCK8//qRT-PCR//Western Blot TGF-β1, UCA1, and HXK2 expression levels were upregulated in tumor tissues comparing with adjacent healthy tissues. Patients that have high serum levels of TGF-β1, UCA1, and HXK2 showed lower overall survival rate compared with patients with low serum levels of TGF-β1, UCA1, and HXK2. TGF-β1, UCA1, and HXK2 overexpression promoted proliferation of hepatocellular carcinoma cell. Yes Patients that have high serum levels of TGF-β1, UCA1, and HXK2 showed lower overall survival rate compared with patients with low serum levels of TGF-β1, UCA1, and HXK2. TGF-β1, UCA1, and HXK2 overexpression promoted proliferation of hepatocellular carcinoma cell. 30070319 UCA1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[MiRNA-124] CCK8//qRT-PCR In the present study we found that miRNA-124 was downregulated, while lncRNA-UCA1 was upregulated in tumor tissues comparing to adjacent healthy tissues of HCC patients.Analysis of followed-up data revealed that low miRNA-124 level and high lncRNA-UCA1 level were closely correlated with poor survival. Overexpression of miRNA-124 led to inhibited lncRNA-UCA1 expression in cells of HCC cell lines, while overexpression of lncRNA-UCA1 failed to significantly affect miRNA-124 expression. Expression levels of miRNA-124 and lncRNA-UCA1 were inversely and significantly correlated in tumor tissues but not in adjacent healthy tissues. Analysis of followed-up data revealed that low miRNA-124 level and high lncRNA-UCA1 level were closely correlated with poor survival. Yes Overexpression of miRNA-124 led to inhibited, while overexpression of lncRNA-UCA1 led to increased proliferation, migration and invasion rates of HCC cell lines. 31354286 UCA1 LncRNA Homo sapiens Carcinoma, Hepatocellular Interaction[UPF1 ] IHC//Western Blot//qRT-PCR//RIP//MTT//Colony Formation Assay//Transwell Assay Up-frameshift protein 1 (UPF1) is a RNA/DNA-dependent ATPase and ATP-dependent RNA helicase. Here, we explored the expression and function of UPF1 in HCC. In this study, we demonstrated that UPF1 expression was significantly reduced in hepatocellular carcinoma (HCC) tissues compared with the adjacent normal tissues. And further functional assays revealed that knockdown of UPF1 promoted HCC cells growth and invasion. Furthermore, we found that UPF1 could bind to long non-coding RNA urothelial cancer associated 1 (UCA1) and was negatively correlated with UCA1. UCA1 expression also affected HCC growth and invasion. Knockdown of UCA1 ameliorated the effect of UPF1 knock down on HCC growth and invasion. Knockdown of UPF1 enhances glycolysis in HCC. Yes Knockdown of UCA1 ameliorated the effect of UPF1 knock down on HCC growth and invasion. 31040354 UCA1 LncRNA Homo sapiens Ovarian Neoplasms tumor tissues and cells Interaction( miR-99b-3p) qRT-PCR//MTT//Western Blot UCA1 was higher in ovarian tumor tissues and cells than normal tissues and cells.Further, UCA1 was shown to regulate the expression of SRPK1 by directly binding to miR-99b-3p. Yes It was demonstrated in this study that knockdown of UCA1 inhibited ovarian cancer cell viability, which a miR-99b-3p inhibitor could reverse in vitro. 35794743 circCYP24A1 CircRNA Homo sapiens Kidney Neoplasms RCC tissue and cells Interaction(circCYP24A1/miR-421/CMTM-4 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//ISH//Transfection//Wound Healing Assay//Colony Formation Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//IHC//Bioinformatics Analysis//Transwell Assay In this study, we identified relatively low hsa_circ_0060927 (circCYP24A1) expression in RCC tissue through high-throughput sequencing and RT-qPCR. Dual-luciferase reporter, RNA immunoprecipitation (RIP), FISH, and RNA-pulldown assays verified that circCYP24A1 inhibited RCC progression by sponging miR-421, thus inducing CMTM-4 expression. Taken together, circCYP24A1 is a prognosis-related circRNA in RCC that functions through the circCYP24A1/miR-421/CMTM-4 axis to modulate RCC progression. Yes CCK-8, Transwell, EdU, and wound-healing assays indicated that circCYP24A1 overexpression inhibited the proliferation, invasion, and migration of RCC cells. Xenograft assays and metastasis models further indicated that circCYP24A1 significantly inhibited the metastasis and proliferation of RCC cells in vivo. 35220395 UCA1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cells Regulation[UCA1-miR-582-5p-ATG7-autophagy axis] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay UCA1 expression was upregulated in bladder cancer tissues and cells.These results provided evidence for a novel UCA1 interaction regulatory network in bladder cancer, that is, UCA1-miR-582-5p-ATG7-autophagy axis. Yes UCA1 expression was upregulated in bladder cancer tissues and cells, while the depletion of UCA1 by shRNA resulted in the suppression of cell proliferation, invasion, migration, and drug resistance. 30666128 UCA1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues interaction[miR-143-3p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Levels of UCA1 and MYO6 were increased significantly in OSCC, while the level of miR-143-3p was decreased compared with the adjacent nontumorous tissues. LncRNA UCA1 contributes to the proliferation and metastasis of OSCC cells by targeting miR-143-3p and upregulating its downstream gene MYO6. Yes UCA1 promoted OSCC cell growth, migration, and invasion both in vitro and in vivo, while miR-143-3p reversed the progression. 32130788 UCA1 LncRNA Homo sapiens Leukemia, Myeloid, Acute HL60 and U937 cells Epigenetics(m6A methylation) CCK8//qRT-PCR//Western Blot Overexpression of UCA1 promotes AML development in vitro. Furthermore, we found that METTL14-influenced m6A methylation could be affected by UCA1. UCA1 promoted AML development by regulating m6A methylation. Moreover, the expression of CYP1B1 and CXCR4 was affected by METTL14. In addition, UCA1 promoted AML development by affecting m6A methylation in vivo. Yes Overexpression of UCA1 promotes AML development in vitro. 35178087 hsa_circ_0000437 CircRNA Homo sapiens Lymph Nodes HLECs Regulation(HSPA2-ERK) FISH Furthermore, both gain-of-function and loss-of-function experiments demonstrated that hsa_circ_0000437 promoted human lymphatic endothelial cells (HLECs) invasion, migration, and tube formation in vitro and also promoted lymphangiogenesis and lymph node metastasis (LNM) in popliteal LNM model in vivo, when it was enriched in GC-secreted exosomes and transferred into HLECs. Mechanistically, exosomal hsa_circ_0000437 induced LNM via HSPA2-ERK signaling pathway independent of VEGF-C. Yes Furthermore, both gain-of-function and loss-of-function experiments demonstrated that hsa_circ_0000437 promoted human lymphatic endothelial cells (HLECs) invasion, migration, and tube formation in vitro and also promoted lymphangiogenesis and lymph node metastasis (LNM) in popliteal LNM model in vivo, when it was enriched in GC-secreted exosomes and transferred into HLECs. Mechanistically, exosomal hsa_circ_0000437 induced LNM via HSPA2-ERK signaling pathway independent of VEGF-C. 36109630 UCA1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Regulation[PI3K/AKT/mTOR pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay In this study, we firstly found UCA1 is upregulated in both osteosarcoma tissues and cell lines, and increased UCA1 is associated with higher tumor stage, larger tumor size and poorer prognosis. Moreover, UCA1 increases CREB1 expression by functioning as a ceRNA against miR-582, thus promoting the EMT process via CREB1-mediated PI3K/AKT/mTOR pathway and finally leading to osteosarcoma metastasis. In this study, we firstly found UCA1 is upregulated in both osteosarcoma tissues and cell lines, and increased UCA1 is associated with higher tumor stage, larger tumor size and poorer prognosis. Yes Then for the first time, we demonstrated that UCA1 promotes the invasion and metastasis of osteosarcoma both in vitro and in vivo. 31011522 UCA1 LncRNA Homo sapiens Osteosarcoma cancer tissues Expression[highly expressed] qRT-PCR//Transwell Assay The results showed that GAS8-AS1 was downregulated, while UCA1 was upregulate in cancer tissues in comparison to adjacent non-cancer tissues of OS patients. Yes Overexpression of UCA1 promoted the migration and invasion of OS cells and attenuated the effects of overexpressing GAS8-AS1. 32013985 UCA1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells Interaction(miR-513b-5p/E2F5 axis) qRT-PCR//Luciferase Report Assay UCA1 expression was enhanced while miR-513b-5p was refrained in osteosarcoma tissues and cells. Downregulation of UCA1 restrained the tumorigenesis of osteosarcoma in vivo through the miR-513b-5p/E2F5 axis. Collectively, knockdown of UCA1 inhibited tumorigenesis and metastasis of osteosarcoma via regulating the miR-513b-5p/E2F5 axis. Yes Downregulation of UCA1 restrained the tumorigenesis of osteosarcoma in vivo through the miR-513b-5p/E2F5 axis. 33595944 UCA1 LncRNA Homo sapiens Osteosarcoma OS cells Interaction(miR-145 and Wnt/β-catenin pathway) In Vivo Experiment//Luciferase Report Assay As a result, a negative association was found between UCA1 and miR-145 in OS cells. UCA1 knockout led to an increase in miR-145 and decreases in HMGA1, p-β-catenin and cyclin D1. In addition, UCA1 upregulation promoted tumor growth in vitro and changed miR-145 and HMGA1 levels in vivo. Moreover, the DLR assay and RNA immunoprecipitation (RIP) showed that UCA1 was likely to regulate HMGA1 levels by sponging miR-145. Yes Both UCA1 knockout and miR-145 over-expression inhibited malignant progression and induced apoptosis in MG-63 and U2OS cells. 36247254 UCA1 LncRNA Homo sapiens Osteosarcoma MHCC97 Cells Interaction [miR-301a/CXCR4 ] qRT-PCR//Western Blot The results revealed that UCA1 expression was relatively higher in MHCC97 cells than in MG63, hFOB1.19, and OS-732 cells.However, the effect of UCA1 knockdown on cell growth and migration was blocked by miR-301a overexpression, whose expression was regulated by UCA1. We also found that miR-301a positively regulated CXCR4 expression. CXCR4 inhibition reversed the effect of miR-301a overexpression on cell growth and migration. Moreover, miR-301a activated the Wnt/β-catenin and NF-κB pathways via regulating CXCR4. Yes Knockdown of UCA1 reduced cell viability, inhibited migration and invasion, and promoted cell apoptosis. 29523218 UCA1 LncRNA Homo sapiens Osteosarcoma osteosarcoma cell lines Regulation( PTEN/AKT signaling pathway ) qRT-PCR//Luciferase Report Assay RT‑qPCR analysis showed that UCA1 expression was significantly increased in osteosarcoma cell lines and promoted cell growth in osteosarcoma. To conclude, our integrated approach demonstrates that UCA1 confers a tumor promoter function by promoting cell proliferation and silencing of the PTEN/AKT signaling pathway in osteosarcoma. Yes RT‑qPCR analysis showed that UCA1 expression was significantly increased in osteosarcoma cell lines and promoted cell growth in osteosarcoma. 29328452 hsa_circ_0087207 CircRNA Homo sapiens Leber'S Hereditary Optic Neuropathy-Like Interaction(miR-665) qRT-PCR//Cell Apoptosis Assay//IF Next-generation sequencing and quantitative real-time PCR revealed the circRNA hsa_circ_0087207 as the most upregulated circRNA in LHON-patient iPSC-derived RGCs. Predicted by bioinformatics approaches, hsa_circ_0087207 acts as the sponge of miR-665 to induce the expression of a variety of apoptosis-related genes in LHON patient iPSC-derived RGCs. Yes Overexpression of hsa_circ_0087207 increased the apoptosis in carrier iPSC-derived RGCs, while knockdown of hsa_circ_0087207 attenuated the apoptosis in LHON-patient iPSC-derived RGCs. 35453537 UCA1 LncRNA Homo sapiens Adenocarcinoma of Lung A549/DDP cells and LUAD tissues Interaction(RBP) RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//Colony Formation Assay//Invasion Assay The results revealed a higher UCA1 expression level in A549/DDP cells and LUAD tissues than in A549 cells and adjacent cancer tissues. Enolase 1 was the RNA-binding protein (RBP) of UCA1. UCA1 expression was significantly associated with distant metastasis, clinical stage, and survival time of patients with LUAD. Yes UCA1 overexpression significantly increased the proliferation, invasion, clone formation, and cisplatin resistance ability and enhanced the expression levels of proliferating cell nuclear antigen and excision repair cross-complementing gene 1 in A549 cells. Tumorigenic assays in nude mice showed that UCA1 knockdown significantly inhibited tumor growth and reduced cisplatin resistance. 34544452 UCA1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cell lines. Interaction(miR-185-5p/HOXA13 axis) Western Blot//Wound Healing Assay//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Bioinformatics Analysis//Transwell Assay The levels of UCA1 and HOXA13 were significantly higher and the expression of miR-185-5p was reduced in LSCC tissues and cell lines.Moreover, miR-185-5p was predicted as a target gene for lncRNA UCA1, while HOXA13 was the target gene for miR-185-5p. UCA1 siRNA and overexpressed HOXA13 reversed the promotive effects of miR-185-5p inhibitor and inhibitory effects of miR-185-5p mimics on cell proliferation and metastasis, respectively. Yes UCA1 siRNA inhibited the proliferation and invasion of LSCC cells, moreover, the proliferation and invasion of LSCC cells were suppressed by miR-185-5p mimics but were enhanced by miR-185-5p inhibitor. 33629307 UCA1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-495/SP1/SP3 ) RNA Pull-Down//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay UCA1 was significantly upregulated in CRC tissues. MiR-495 was inversely correlated to the expression of UCA1. The results indicated that UCA1 sponged miR-495, leading to the disinhibition of SP1/SP3 expression. SP1/SP3 induced the expression of DNA methyltransferases and, in turn, contributed to UCA1 mediated tumor-promoting actions. Yes UCA1 enhanced cell proliferation, migration/invasion, angiogenesis, epithelial-mesenchymal transition, and resistance to 5-FU in CRC cell lines. 33961855 mmu_circ_0001845 CircRNA Homo sapiens Colitis-Associated Neoplasms Regulation In Vivo Experiment//Western Blot//Transfection//FISH//qRT-PCR//RNA-seq//Luciferase Report Assay The K-means clustering algorithm packaged these differential expressed circRNAs into subgroup analysis, and the data strongly implied that mmu_circ_0001109 closely correlated to the pro-inflammatory signals, while mmu_circ_0001845 was significantly associated with the Wnt signalling pathway.By RNA blasting between mice and humans, the human RTEL1- and PRKAR2A-derived circRNAs, which might be considered as homeotic circRNAs of mmu_circ_0001109 and mmu_circ_0001845, respectively, were identified. However, three PRKAR2A-derived circRNAs, which had the high RNA similarities to mmu_circ_0001845, were remarkably up-regulated in CAC tissue samples and promoted the transition from colitis to CAC. Yes Our subsequent data in vivo and in vitro confirmed that mmu_circ_0001109 could exacerbate the colitis by up-regulating the Jak-STAT3 and NF-kappa B signalling pathways, and mmu_circ_0001845 promoted the CAC transformation through the Wnt signalling pathway. 35184406 UCA1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues Expression(highly expressed) CCK8//qRT-PCR//Transfection//Western Blot In this research, data mining revealed that upregulated UCA1 occurred in PDAC patients, which meant a high likelihood of a poor prognosis. In this research, data mining revealed that upregulated UCA1 occurred in PDAC patients, which meant a high likelihood of a poor prognosis. Yes Following, UCA1 silencing could notably decrease cell viability and induce cell apoptosis. Further research revealed that UCA1 silencing could induce more cytochrome c localization in the cytosol, which triggered the mitochondrial apoptotic pathway in PDAC cell lines. 33350847 UCA1 LncRNA Homo sapiens Fatty Liver, Alcoholic patients with AFL, L02 cells Interaction(miR-214/KLF5 ) Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Microarray//Bioinformatics Analysis In this study, we first detected the expression of UCA1 was up-regulated in serum of patients with AFL and ethanol-induced L02 cells. Besides, lncRNA UCA1 regulated the expression of KLF5 by sponging miR-214. LncRNA UCA1 regulated the biological behavior of ethanol-induced L02 cells by sponging miR-214, which may provide novel therapeutic strategies for alcoholic fatty liver. Yes And knockdown of UCA1 reversed the inhibiting effect of ethanol on the biological behavior of L02 cells including cell proliferation, migration, and apoptosis. 35381856 hsa_circ_0026579 CircRNA Homo sapiens Pneumonia WI-38 cells Interaction(miR-24-3p/IGF2 axis) Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//ELISA Circ_0026579 knockdown alleviated LPS-induced WI-38 cells inflammation by miR-24-3p/IGF2 axis, suggesting that circ_0026579 might contribute to infantile pneumonia progression. Yes Circ_0026579 expression was promoted in LPS-induced WI-38 cells, and its knockdown alleviated LPS-induced WI-38 cells inflammation. 35142578 UCA1 LncRNA Mus musculus Parkinson Disease brain tissues Regulation[SNCA] qRT-PCR UCA1 and SNCA were highly expressed in brain tissues extracted from PD mice and MPP+-induced SH-SY5Y cells. LncRNA-UCA1 promotes the occurrence and progression of PD by upregulating SNCA expression. Yes Higher viability was seen after the UCA1 knockdown in MPP+-induced SH-SY5Y cells. 30536337 UCA1 LncRNA Mus musculus Polycystic Ovary Syndrome PCOS mice Regulation(PI3K/AKT signaling pathway) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//H&E Staining//Cell Cycle Assay//ELISA Western blot also revealed that UCA1 knockdown in PCOS mice repressed AKT activation, inhibitor experiment demonstrated that suppression of AKT signaling pathway, inhibited the cell proliferation and promoted apoptosis. Yes CCK8 assay and Flow cytometry were used to do the cell cycle, apoptosis and proliferation analysis, the results showed that UCA1 knockdown in KGN cells inhibited cell proliferation by blocking cell cycle progression and promoted cell apoptosis. In the in vivo experiment, the ovary of PCOS mice was injected with lentivirus carrying sh-UCA1, the results showed that knockdown of lncRNA UCA1 attenuated the ovary structural damage, increased the number of granular cells, inhibited serum insulin and testosterone release, and reduced the pro-inflammatory cytokine production. 33743811 UCA1 LncRNA Mus musculus Cardiomyocyte Hypertrophy mice heart Interaction(miR-184/HOXA9 Axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//IF In this paper, qRT-PCR analysis exhibited that lncRNA UCA1 was highly expressed in mice heart treated with transverse aortic constriction (TAC) and the cardiomyocytes treated with phenylephrine (PE). On the contrary, miR-184 was downregulated under the same conditions. In addition, it was deduced that lncRNA UCA1 was reversely related with miR-184 in PE-triggered hypertrophic cardiomyocytes, confirmed by the Spearman correlation analysis. Later, it was determined that miR-184 was a direct target of UCA1, whereas the mRNA HOXA9 was a target of miR-184. Rescue assays indicated that UCA1 promoted the progression of cardiac hypertrophy through competitively binding with miR-184 to enhance the expression of HOXA9. Yes The knockdown of UCA1 or the overexpression of miR-184 lessened the enlarged surface area of cardiomyocytes and the elevated expressions of fetal genes (ANP and BNP) induced by PE. 29616999 UCA LncRNA Homo sapiens Lung Neoplasms lung cancer cells Regulation[microRNA-143] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay It was found that the lncRNA UCA was significantly (p < 0.05) upregulated in the lung cancer cells and silencing of UCA1 could inhibit the proliferation of the SK-MES-1 lung cancer cells via induction of G2/M cell cycle arrest and apoptosis. Therefore, it is concluded that UCA1 regulates the growth of the SK-MES-1 lung cancer by inhibition of MAPK1 via miR-143 upregulation. Yes It was found that the lncRNA UCA was significantly (p < 0.05) upregulated in the lung cancer cells and silencing of UCA1 could inhibit the proliferation of the SK-MES-1 lung cancer cells via induction of G2/M cell cycle arrest and apoptosis. 30556875 uc061hsf.1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Interaction[p53] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Through this approach, we identified the novel lncRNA uc061hsf.1, which was expressed in low level in ESCC and was correlated with lymph node metastasis and poor differentiation in ESCC patients. Mechanistically, lncRNA uc061hsf.1 was induced by p53, and luciferase reporter gene confirmed that lncRNA uc061hsf.1 was a direct transcriptional target of p53. We further found that uc061hsf.1 was able to regulate expression of the transcription factor FoxA1, thereby potentially influencing tumor cell migration. In conclusion, these results suggest that p53-regulated lncRNA uc061hsf.1 is a cancer suppressor gene which is associated with tumor progression in ESCC. Yes Knockdown or overexpression of lncRNA uc061hsf.1 in ESCC cells promoted or inhibited cell proliferation and metastasis, respectively. 31743955 mmu_circ_0001109 CircRNA Homo sapiens Colitis-Associated Neoplasms Regulation In Vivo Experiment//Western Blot//Transfection//FISH//qRT-PCR//RNA-seq//Luciferase Report Assay The K-means clustering algorithm packaged these differential expressed circRNAs into subgroup analysis, and the data strongly implied that mmu_circ_0001109 closely correlated to the pro-inflammatory signals, while mmu_circ_0001845 was significantly associated with the Wnt signalling pathway.By RNA blasting between mice and humans, the human RTEL1- and PRKAR2A-derived circRNAs, which might be considered as homeotic circRNAs of mmu_circ_0001109 and mmu_circ_0001845, respectively, were identified. However, three PRKAR2A-derived circRNAs, which had the high RNA similarities to mmu_circ_0001845, were remarkably up-regulated in CAC tissue samples and promoted the transition from colitis to CAC. Yes Our subsequent data in vivo and in vitro confirmed that mmu_circ_0001109 could exacerbate the colitis by up-regulating the Jak-STAT3 and NF-kappa B signalling pathways, and mmu_circ_0001845 promoted the CAC transformation through the Wnt signalling pathway. 35184406 UCA1 LncRNA Homo sapiens Abortion, Spontaneous villi tissues regulation[UCA1/miR-455/RUNX2 signaling] CCK8//qRT-PCR//EdU Staining//Transwell Assay Here, we revealed that, compared with that in clinical samples from elective induced abortion, UCA1 expression was decreased in samples from SA patients as shown by qPCR method.Ultimately, we illustrated that UCA1 plays its role via absorbing miR-455, thus promoting RUNX2 expression in HTR-8/SVneo cells. Yes Then, we found that knockdown of UCA1 reduced cell viability and inhibited cell proliferation and migration of HTR-8/SVneo trophoblast cells as shown by CCK8, EdU, and Transwell methods. 33085763 hsa_circ_0004140 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tumor and cells Interaction(circ_0004140/miR-1184/CCL22 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//CCK8//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//IHC//Transwell Assay Herein, we identify a novel circRNA (circ_0004140), derived from the oncogene YAP1, which is up-regulated in LUAD. Mechanistically, circ_0004140 served as a sponge of miR-1184 targeting C-C motif chemokine ligand 22(CCL22). The high expression of circ_0004140 is correlated with poor prognosis and CTL cells dysfunction in LUAD patients. Yes Knockdown of circ_0004140 regulated LUAD cells proliferation, migration, and apoptosis. 35396377 uc003xsl.5 LncRNA Homo sapiens Triple Negative Breast Neoplasms tissues Interaction(NFκB) In Vivo Experiment//RNA Pull-Down//RIP//ChIP Here we report that a novel long noncoding RNA (lncRNA) Uc003xsl.1 is highly expressed in triple-negative breast cancer (TNBC) and correlates with poor outcomes in patients with TNBC. Uc003xsl.1 directly bound nuclear transcriptional factor NFκB-repressing factor (NKRF), subsequently preventing NKRF from binding to a specific negative regulatory element in the promoter of the NFκB-responsive gene IL8 and abolishing the negative regulation of NKRF on NFκB-mediated transcription of IL8. Activation of the NFκB/IL8 axis promoted the progression of TNBC. Here we report that a novel long noncoding RNA (lncRNA) Uc003xsl.1 is highly expressed in triple-negative breast cancer (TNBC) and correlates with poor outcomes in patients with TNBC. Yes In this study, a Trop2-targeting, redox-responsive nanoparticle was developed to systematically deliver Uc003xsl.1 siRNA to TNBC cells in vivo, which reduced Uc003xsl.1 expression and suppressed TNBC tumor growth and metastasis. 34965935 circSatb1 CircRNA Homo sapiens Epilepsy, Temporal Lobe mTLE patients and experimental epilepsy Expression(lower expressed) In Vivo Experiment//qRT-PCR//Transfection//RNA-seq Interestingly, hippocampal expression of circ_Satb1, a circRNA derived from special AT-rich sequence binding protein 1 (SATB1), is decreased in both mTLE patients and in experimental epilepsy. Overall, our results identify a novel epilepsy-associated circRNA with disease-specific expression and previously unidentified cellular effects that are relevant for epileptogenesis. Yes Our work shows that circ_Satb1 displays dynamic patterns of neuronal expression in vitro and in vivo. 35310884 uc003pxg.1 LncRNA Homo sapiens Coronary Artery Disease 80 patients with CAD Interaction(miR‑25‑5p ) Western Blot//Bioinformatics Analysis//qRT-PCR//FISH//Luciferase Report Assay//RNA-seq//Cell Cycle Assay//EdU Staining//Transwell Assay The results demonstrated that the levels of uc003pxg.1 were significantly upregulated (~4.6?fold) in samples from 80 patients with CAD compared with those in 80 healthy subjects. Yes Subsequently, the present study demonstrated that small interfering RNA‑mediated uc003pxg.1 knockdown inhibited human umbilical vein endothelial cell (HUVEC) proliferation and migration, which was analyzed using the Cell Counting Kit‑8, cell cycle, EdU and Transwell assays. 34212983 hsa_circ_0058493 CircRNA Homo sapiens Silicosis 84 individuals Expression(highly expressed) qRT-PCR//Transfection//RNA-seq//Western Blot Furthermore, at the enlarged sample validation stage, hsa_circ_0058493 was highly expressed in both silicosis and IPF cases (silicosis: P = 1.16 × 10-6; IPF: P = 7.46 × 10-5). These shreds of evidence indicated that hsa_circ_0058493 might serve as a novel biomarker for diagnosing silicosis and IPF. Yes Additionally, hsa_circ_0058493 expression was significantly increased in MRC-5 cells upon TGF-β1 treatment, while hsa_circ_0058493 knockdown inhibited the expression of fibrotic molecules by affecting the epithelial-mesenchymal transition process. 35378401 hsa_circ_0017109 CircRNA Homo sapiens Lung Neoplasms NSCLC tumor samples and cells Interaction(miR-671-5p/FZD4 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay Circ_0017109 was upregulated in NSCLC tumor samples and cells. MiR-671-5p was identified as a target of circ_0017109, and circ_0017109 negatively impacted on miR-671-5p expression. MiR-671-5p downregulated FZD4 and dampened the activity of Wnt/β-catenin signaling pathway. Circ_0017109 modulated FZD4 expression by suppressing miR-671-5p activity. Yes Silencing circ_0017109 impaired cell proliferation and promoted apoptosis in NSCLC cells, and circ_0017109 knockdown suppressed in vivo tumorigenesis of NSCLC cells in mouse xenograft model. 36434577 uc.77- LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-4676-5p/FBXW8 axis ) qRT-PCR//IHC//Luciferase Report Assay We performed T-UCR microarray analysis and found that uc.77- was significantly downregulated in CRC tissues and cell lines. The present findings highlight the role of the uc.77-/miR-4676-5p/FBXW8 axis in CRC and identify uc.77- as a potential novel target for the treatment of CRC. Yes Ectopic expression of uc.77- significantly inhibited the proliferation of CRC cells in vitro and the growth of xenograft tumors in nude mice in vivo. 34094975 uc.77 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cell lines Expression(highly expressed) Other The relative expression levels of uc.77 in lung cancer cell lines 95D, H1299, A549, H460, H446 and 16HBE-T were significantly higher than that of 16HBE cells (P<0.05). The uc.77 RNA expression levels of lung cancer tissues was significantly higher than that of the adjacent normal tissues (P<0.001). In addition, increased lncRNA uc.77 expression was significantly associated with big tumor size, lymph node metastasis and advanced TNM stage (P<0.05). Yes After transfection with uc.77 siRNA, the expressions of uc.77 in H1299, 95-D and 16HBE-T cells were reduced (P<0.05), and the cell proliferation capacities were reduced at 48 hours and 72 hours (P<0.05). After transfection with uc.77 siRNA-1, the G(0)/G(1) phase cell ratio of H1299 siRNA-1 group [(71.86±3.46)%] was higher than those of H1299-control group [(47.62±5.48)%] and H1299 siRNA-NC group [(61.38±5.62)%, P<0.05], S phase cell ratio of H1299 siRNA-1 group [(14.99±3.61)%] was lower than those of H1299-control group [(34.95±7.05)%] and H1299 siRNA-NC group [(23.75±5.87)%, P<0.05], the apoptosis rate of H1299 siRNA-1 group [(4.90±1.80)%] was higher than those of H1299-control group [(3.30±0.80)%] and H1299 siRNA-NC group [(2.80±1.20)%, P<0.05], the colony formation rate of H1299 siRNA-1 group [(19.20±2.00)%] was lower than those of H1299 control group [(32.60±2.00)%] and H1299 siRNA-NC group [(34.40±1.00)%, P<0.05]. 36319456 UCA1 LncRNA Homo sapiens Pituitary Neoplasms Pituitary tumor tissues Expression[highly expressed] qRT-PCR Consistent with other cancers, lncRNA-UCA1 was highly expressed in pituitary tumors. Yes Overexpression of lncRNA-UCA1 in rat pituitary cancer cell lines, GH3 and MMQ, significantly promoted glucose uptake and lactate production. 32909148 UCA1 LncRNA Homo sapiens Cystitis primary CG cells Regulation[UCA1/miR-204/CCND2 pathway ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay In this study, we firstly isolated the primary cells from the tissues of CG and adjacent normal tissues, and found that UCA1 was up-regulated in the primary CG cells (pCGs).Ultimately, we revealed the role and regulation of UCA1/miR-204/CCND2 regulatory axis in pCGs. Yes Then, we showed that knock out of UCA1 reduced the cell viability, inhibited the cell proliferation and restrained the migration potential and overexpression of UCA1 promoted that in pCGs. 30999112 UCA1 LncRNA Homo sapiens Prostatic Neoplasms PC tissues Interaction[Sponging miR143] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Then we demonstrated that repressed UCA1 promoted the microRNA-143 (miR-143) expression and miR-143 could bind to the predicted binding site of UCA1. We then proved the anti-tumor role of miR-143 in PCa. Furthermore, we found that miR-143 displays its role in PCa via modulating the MYO6 expression. Yes In this study, we confirmed the role of UCA1 in PCa and found that UCA1 Expression[down-expression]regulation inhibited cell proliferation of PCa cells. 31954329 UCA1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues and cell lines regulation[suppressing miR-331-3p expression] qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay In the present study, it was revealed that the expression of UCA1 was significantly upregulated, while miR-331-3p was downregulated in DLBCL tissues and cell lines. In conclusion, the present findings firstly demonstrated that UCA1 silencing restrained DLBCL cell proliferation and metastases viability by suppressing miR-331-3p expression. Yes Functionally, knockdown of UCA1 was revealed to suppress cell proliferation, migration and invasion in DLBCL cells. 33262831 UCA1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues,cell lines Interaction[UCA1-miR-204-CXCR4 ] Western Blot//CCK8//RIP//qRT-PCR//Transwell Assay In consistent, we found the expression levels of UCA1 was higher in the PCa cell lines PC-3, LnCaP, and DU-145 than in the normal prostate epithelial cell line RWPE-1 (P<0.01). Our data showed that UCA1 is frequently overexpressed in PCa tissues compared with BPH tissues (P<0.01).Taken together, our research revealed that UCA1 works as an oncogene by targetting miR-204. The UCA1-miR-204-CXCR4 regulatory network regulated the growth and metastasis of PCa, providing new insight in the management of patients with such malignancy. Yes Functionally, we found knockdown of UCA1 in PC-3 significantly suppressed cell growth and invasion of PC-3, while overexpression of UCA1 in DU-145 cells promote cell growth and invasion. 30940776 hsa_circ_0000064 CircRNA Homo sapiens Renal Tubular Epithelial Cells (Rtecs) Injury Interaction(miR-532-3p/ROCK1 axis) RNA Pull-Down//Western Blot//Transfection//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//EdU Staining Our results revealed that HG treatment could promote HK-2 cells oxidative stress, apoptosis, fibrosis, and inhibit proliferation. Circ_0000064 expression was increased in the serum of DN patients and HG-induced HK-2 cells, and silenced circ_0000064 could relieve HG-induced HK-2 cells injury. MiR-532-3p could be sponged by circ_0000064, and its overexpression also alleviated HG-induced HK-2 cells injury. Besides, the regulation of circ_0000064 knockdown on HG-induced HK-2 cells injury could be reversed by miR-532-3p inhibitor. Additionally, ROCK1 was a target of miR-532-3p, and its expression was inhibited by circ_0000064 knockdown. The inhibition effect of circ_0000064 knockdown on HG-induced HK-2 cells injury also could be reversed by overexpressing ROCK1. Yes Circ_0000064 expression was increased in the serum of DN patients and HG-induced HK-2 cells, and silenced circ_0000064 could relieve HG-induced HK-2 cells injury. MiR-532-3p could be sponged by circ_0000064, and its overexpression also alleviated HG-induced HK-2 cells injury. Besides, the regulation of circ_0000064 knockdown on HG-induced HK-2 cells injury could be reversed by miR-532-3p inhibitor. Additionally, ROCK1 was a target of miR-532-3p, and its expression was inhibited by circ_0000064 knockdown. 35291991 UCA1 LncRNA Homo sapiens Retinoblastoma RB tissues and the RB cell lines regulation[PI3K/Akt pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay LncRNA-UCA1 was highly expressed in both RB tissues and the RB cell lines HXO-RB44 and Y79. Our study showed that lncRNA-UCA1 could promote cell proliferation and cell cycle progression and inhibit cell apoptosis in RB by activating the PI3K/Akt pathway. Moreover, lncRNA-UCA1 expression levels in RB patients were correlated with tumour size, optic nerve invasion, and pathologic grade. Yes LncRNA-UCA1 promoted cell proliferation and cell cycle progression and inhibited apoptosis in HXO-RB44 and Y79 cells. LncRNA-UCA1 overexpression dramatically increased the expression of S6k and the phosphorylation of PI3K and Akt in RB cells. 35117446 UCA1 LncRNA Homo sapiens Retinoblastoma retinoblastoma tissues and cells Interaction(miR-124/c-myc axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay This study found that UCA1 expression in retinoblastoma tissues and cells was dramatically upregulated relative to that of healthy controls. Mechanistically, UCA1 promoted c-myc expression through sponging miR-124. miR-124 inhibition or c-myc overexpression partially reversed the effects of UCA1 knockdown on retinoblastoma cells. Yes Functionally, UCA1 knockdown could suppress retinoblastoma cells' proliferation, migration and invasion, and facilitate their apoptosis. Knockdown of UCA1 also retarded the growth of xenograft tumors in vivo. 35422898 UCA1 LncRNA Homo sapiens Thyroid Carcinoma, Anaplastic ATC cell lines and tissues interaction[miR-135a-mediated c-myc activation] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The present study identified that the expression levels of UCA1, in ATC cell lines and tissues, were significantly upregulated compared with normal human thyroid cell line and adjacent non?cancerous tissues, respectively. In addition, using luciferase assays, it was confirmed that miR‑135a directly bound to UCA1 and the 3' untranslated region of c‑myc, and UCA1 competed with c‑myc for miR‑135a binding. miR‑135a inhibition may upregulate c‑myc expression, however, the upregulation of c‑myc may be partially reduced by short hairpin UCA1. Yes UCA1 knockdown significantly inhibited ATC cell viability, proliferation, migration and invasion and the expression level of c?myc proto?oncogene (c?myc) in vitro, and suppressed ATC tumor growth in vivo. 30015867 UCA1 LncRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues regulation[miR-138-5p/CCR7 axis] Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that UCA1 and CCR7 were upregulated, while miR-138-5p was downregulated in TSCC tissues. In conclusion, lncRNA UCA1 might function as an oncogene in TSCC through regulating the miR-138-5p/CCR7 axis, providing a new biomarker for TSCC treatment. Yes Silenced UCA1 restrained the proliferation, migration, invasion, and glycolysis metabolism of TSCC cells. 32749849 hsa_circ_0007006 CircRNA Homo sapiens Graves Ophthalmopathy Regulation qRT-PCR//RNA-seq//Western Blot RNA sequencing results predicted a total of 7489 circRNAs and 15,803 mRNAs, with 94 upregulated and 76 downregulated circRNAs and 488 upregulated and 138 downregulated mRNAs. The qRT-PCR analysis of seven dysregulated circRNAs and two major mRNAs validated the RNA-sequencing data. The competing endogenous RNA (ceRNA) network included 7 circRNAs, 23 miRNAs, and 262 mRNAs. Functional analysis revealed several important pathways. Overexpression of hsa_circ_0007006 led to decreased expression levels of COL1A1 and MMP2. Activation of the relaxin signaling pathway differed between the two subtypes. We showed that circRNAs are differentially expressed between type I and type II TAO. We speculate that the hsa_circ_0007006-COL1A1 and MMP2-relaxin signaling pathways are important regulatory axes in the pathogenesis of this disease type and could be considered promising diagnostic and therapeutic targets in the future. Yes Functional analysis revealed several important pathways. Overexpression of hsa_circ_0007006 led to decreased expression levels of COL1A1 and MMP2. Activation of the relaxin signaling pathway differed between the two subtypes. 36409215 circEZH2 CircRNA Homo sapiens Neoplasms CRC tissues Regulation(circEZH2/miR-133b/IGF2BP2/ CREB1 regulatory axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//H&E Staining//IHC//Transwell Assay Here, a novel circRNA named circEZH2 (hsa_circ_0006357) was screened out by RNA-seq in CRC tissues, whose expression is closely related to the clinicpathological characteristics and prognosis of CRC patients. Biologically, circEZH2 facilitates the proliferation and migration of CRC cells in vitro and in vivo. Mechanistically, circEZH2 interacts with m6A reader IGF2BP2 and blocks its ubiquitination-dependent degradation. Meanwhile, circEZH2 could serve as a sponge of miR-133b, resulting in the upregulation of IGF2BP2. Particularly, circEZH2/IGF2BP2 enhances the stability of CREB1 mRNA, thus aggravating CRC progression. Here, a novel circRNA named circEZH2 (hsa_circ_0006357) was screened out by RNA-seq in CRC tissues, whose expression is closely related to the clinicpathological characteristics and prognosis of CRC patients. Yes Biologically, circEZH2 facilitates the proliferation and migration of CRC cells in vitro and in vivo. Mechanistically, circEZH2 interacts with m6A reader IGF2BP2 and blocks its ubiquitination-dependent degradation. 35773744 UCA1 LncRNA Homo sapiens Pre-Eclampsia PE tissues regulation[downregulating JAK2] qRT-PCR The UCA1 level was markedly upregulated in PE pregnancies relative to non-PE ones in GSE75010 and tissues. In short, UCA1 is upregulated in the trophocytes of PE pregnancies and accelerates trophoblast cell invasion and proliferation by downregulating JAK2. Yes Knockdown of UCA1 accelerated the proliferative migratory abilities and cell cycle progression, but inhibited apoptosis of HTR-8/SVneo and JAR cells. 32067230 circANKRD42 CircRNA Homo sapiens Pulmonary Fibrosis peripheral blood Regulation(miR-324-5p) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay Mechanistic studies revealed that the heterogeneous nuclear ribonucleoprotein L (hnRNP L) activated the circANKRD42 reverse splicing biogenesis. The biogenetic circANKRD42 sponged miR-324-5p to promote the AJUBA expression, which blocked the binding between phosphorylated yes-associated protein 1 (YAP1) and large tumor suppressor kinase 1/2 (LATS1/2), leading to increased YAP1 entering the nucleus. circANKRD42 also sponged miR-136-5p to promote the YAP1 translation. Accumulating YAP1 in nucleus bound to TEAD, which initiated the transcription of genes related to mechanical stiffness. Finally, the therapeutic effect of circANKRD42 was evaluated in mice and the association between circANKRD42 and clinicopathological features was analyzed in IPF patients. Our findings supported that circANKRD42 is a promising biomarker and a potential therapeutic target related to cytoskeleton tension for IPF treatment. Our findings supported that circANKRD42 is a promising biomarker and a potential therapeutic target related to cytoskeleton tension for IPF treatment. Yes Mechanistic studies revealed that the heterogeneous nuclear ribonucleoprotein L (hnRNP L) activated the circANKRD42 reverse splicing biogenesis. 35278674 hsa_circ_0061140 CircRNA Homo sapiens Adenomyosis endometrial epithelial cells Interaction(miR-141-3p/LIN28B ) Western Blot//Bioinformatics Analysis//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Circ_0061140 expression was upregulated in adenomyosis patients. Circ_0061140 served as a miRNA sponge for miR-141-3p, and miR-141-3p silencing partly reversed circ_0061140 knockdown-induced effects in endometrial epithelial cells. miR-141-3p directly interacted with LIN28B mRNA. LIN28B overexpression partly diminished miR-141-3p overexpression-mediated influences in endometrial epithelial cells. Circ_0061140 knockdown downregulated LIN28B expression by elevating miR-141-3p level in endometrial epithelial cells. Yes Circ_0061140 knockdown suppressed the viability, proliferation, invasion, and migration and triggered the apoptosis of endometrial epithelial cells. 35947965 UCA1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell line Regulation( hnRNP F/FGFR2/PI3k-AKT axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//FISH//qRT-PCR//IHC//Invasion Assay In this study, it is revealed that the urinary concentration of N-Nitrosodiethylamine is higher in high incidence area of ESCC, and the lncRNA-UCA1(UCA1) is significantly decreased in ESCC tissues. Mechanically, through binding to heterogeneous nuclear ribonucleoprotein F (hnRNP F) protein, UCA1 regulates alternative splicing of fibroblast growth factor receptor 2 (FGFR2), which promotes the FGFR2IIIb isoform switching to FGFR2 IIIc isoform, and the latter activates epithelial-mesenchymal transition via PI3K-AKT signaling pathways impacting tumorigenesis. Yes In vitro and in vivo experiments further show that UCA1 is involved in the malignant transformation of Het-1A cells and precancerous lesions of the rat esophagus induced by N-nitrosomethylbenzylamine (NMBzA). Functional gain and loss experiments verify UCA1 can affect the proliferation, migration, and invasion of ESCC cells in vitro and in vivo. 36169023 UCA1 LncRNA Homo sapiens Endometriosis EMS tissues Expression[highly expressed] qRT-PCR qRT-PCR analysis showed that the expression of lncRNA UCA1 in EMS was increased (P<0.01). Yes Knockdown of UCA1 in vitro significantly inhibited the proliferation of endometrial stromal cells (ESCs) and induced autophagy and apoptosis. 33680939 UCA1 LncRNA Homo sapiens Adrenal Cortex Neoplasms ACC tissues Regulation[miR-298-CDK6 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay Here, we found that the long noncoding RNA urothelial carcinoma-associated 1 (UCA1) was highly expressed in ACC tissues and closely associated with the TNM stage and metastasis of ACC patients.Taken together, our results identified the potential oncogenic function of UCA1 in ACC by regulating the miR-298-CDK6 axis. Here, we found that the long noncoding RNA urothelial carcinoma-associated 1 (UCA1) was highly expressed in ACC tissues and closely associated with the TNM stage and metastasis of ACC patients. Yes Overexpression of UCA1 significantly promoted the proliferation and suppressed the apoptosis of ACC cells. 30935924 hsa_circ_002363 CircRNA Homo sapiens Diseases Following Exposure To Environmental Chemicals 16HBE cells Interaction(BCAS2) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//FISH//Cell Apoptosis Assay//IP//IHC We found that NPs-Nd2O3 exposure induced DNA damage and down-regulated levels of circular RNA (circRNA) circ_002363 in 16HBE cells as well as in rat lung tissue. We also observed that circ_002363 levels in the serum of workers employed in the production of NPs-Nd2O3 diminished as the work time progressed, suggesting that circ_002363 may be a potential biomarker of lung injury. Functional experiments showed that circ_002363 significantly inhibited DNA damage induced by NPs-Nd2O3. RNA pull-down and western blot assays found that circ_002363 interacted with proteins PARP1/Ku70/Ku80/Rad50, which are critical participants in non-homologous end-joining (NHEJ) DNA repair. Moreover, we found that formation of circ_002363 was regulated by the RNA binding protein Breast Carcinoma Amplified Sequence 2 (BCAS2). The BCAS2 protein affected circ_002363 expression through interaction with Pre-DNA2, the host gene of circ_002363, in NPs-Nd2O3-exposed 16HBE cells. In conclusion, our findings show first that circ_002363, which is regulated by BCAS2, acts as regulator of DNA damage via the NHEJ pathway. These results enhance our understanding of the regulatory mechanisms controlling the actions of circular RNAs and highlight the relationship between genetics and epigenetics in the development of diseases following exposure to environmental chemicals. Yes Functional experiments showed that circ_002363 significantly inhibited DNA damage induced by NPs-Nd2O3. RNA pull-down and western blot assays found that circ_002363 interacted with proteins PARP1/Ku70/Ku80/Rad50, which are critical participants in non-homologous end-joining (NHEJ) DNA repair. 36526188 hsa_circ_0082633 CircRNA Homo sapiens Virus Diseases A549 cells Expression(highly expressed) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Microarray We further confirmed that circRNA_0082633 expression was increased following IAV infection. Interestingly, the activation of Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling was involved in IAV-induced circ_0082633 expression. More importantly, we demonstrated that circ_0082633 expression enhanced type I interferon (IFN) signaling by IFN-stimulated response element (ISRE) promoter activity and Ifnb1 mRNA levels. Yes Overexpression of circRNA_0082633 suppressed IAV infection while depletion of circRNA_0082633 promoted viral proliferation. 35290928 UCA1 LncRNA Homo sapiens Thyroid Carcinoma, Anaplastic ATC tissues and cells Interaction(miR-148a/PD-L1 pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay UCA1 and PD-L1 expression levels were elevated in ATC tissues and cells. UCA1 negatively regulated the expression of miR-148a, and miR-148a targeted PD-L1 to down-regulate its expression. Besides, we found that UCA1 attenuated the killing effect of cytotoxic CD8 + T cells and reduced cytokine secretion through PD-L1 and miR-148a. Yes . Silencing UCA1 and PD-L1 enhanced the killing effect of cytotoxic CD8 + T cells on ATC cells. Finally, silencing UCA1 or PD-L1 in ATC cells restored the suppression of the killing effect of CD8 + T cells in vivo. 33486611 UCA1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Interaction(miR-185/NOTCH3 Signaling) qRT-PCR//MTT//Transwell Assay//Western Blot UCA1 was confirmed to be highly expressed in colorectal cancer. Both UCA1 and NOTCH3 were validated as direct targets of miR-185. Silencing UCA1 repressed NOTCH3 expression through the miR-185 sponge. NOTCH3 was found to be highly expressed in CRC patients and positively related to UCA1 expression. Moreover, the UCA1 expression level was positively related to tumor stages. Yes Silencing UCA1 showed inhibitory effect on cell proliferation and metastasis. 34733326 circTLK1 CircRNA Homo sapiens Ischemic Stroke IS models Interaction(miR-26a-5p/PTEN/IGF-1 R/GLUT1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//IHC circTLK1 and PTEN were highly expressed while miR-26a-5p was under-expressed in IS models. circTLK1 and miR-26a-5p were co-located in the N2a cell cytoplasm. circTLK1 regulated PTEN as a sponge of miR-26a-5p. PTEN positively regulated IGF-1 R and GLUT1 expressions. miR-26a-5p inhibitor annulled the repressive effects of circTLK1 silencing on OGD/R-induced neuronal injury. sh-PTEN partially annulled the effects of the miR-26a-5p inhibitor on OGD/R-induced neuronal injury. Yes circTLK1 knockdown decreased infarct volume and neurological impairment in MCAO mouse models and relieved OGD/R-induced neuronal injury in vitro. 35067172 uc.48+ LncRNA Rattus norvegicus Neuroinflammatory Diseases dorsal root ganglia of gp120-treated rats Regulation(P2Y12) In Vivo Experiment//Western Blot//ISH//Transfection//qRT-PCR Long non-coding RNA uc.48+ was increased in the dorsal root ganglia of gp120-treated rats, and small interfering RNA that targets uc.48+ markedly alleviated hyperalgesia in gp120-treated rats.Uc.48+ small interfering RNA inhibited P2Y12 expression in gp120-treated rats. Uc.48+ potentiated P2Y12 receptor functions in the neurons and heterologous cells. Yes Notably, uc.48+ overexpression increased P2Y12 expression in control rats dorsal root ganglia and induced hyperalgesia. 34326715 UVRAG CircRNA Homo sapiens Urinary Bladder Neoplasms cell lines Regulation[miR-223/FGFR2 axis ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay "Results showed that circUVRAG was upregulated in BLCA cell lines. Downregulation of circUVRAG suppressed FGFR2 expression by ""sponging"" miR-223, which was confirmed by rescue experiments and luciferase reporter assay. Overall, the results showed that downregulation of circUVRAG suppressed the aggressive biological phenotype of BLCA. Taken together, silencing circular RNA UVRAG inhibited bladder cancer growth and metastasis by targeting the miR-223/FGFR2 axis, which may provide a potential biomarker and therapeutic target for the management of BLCA." Yes Downregulation of circUVRAG expression suppressed proliferation and metastasis both in vitro and in vivo. 30387298 VIM-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay VIM-AS1 was expressed significantly higher in PCa tissues comparing with normal prostate tissues. Higher VIM-AS1 expression predicted larger tumor size, metastasis and advanced TNM stage. Yes Inhibition of VIM-AS1 reduced cell proliferation, migration and invasion of PC3 cells but overexpression of VIM-AS1 promoted cell growth, migration and invasion. 31786880 VESTAR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction(VEGFC/HuR ) ISH//RIP//RNA Pull-Down Here we show that VEGFC mRNA stability-associated long noncoding RNA (VESTAR) is involved in lymph node metastasis of ESCC. Mechanistically, VESTAR directly bound and stabilized VEGFC mRNA. VESTAR also interacted with HuR, a positive regulator of VEGFC mRNA stability, and increased HuR binding to VEGFC mRNA. VESTAR was overexpressed in ESCC tissues and was predictive of poor prognosis in patients with ESCC. In ESCC, NXF1 and SRSF3 facilitated nuclear export of VESTAR to the cytoplasm, which was associated with lymph node metastasis. Yes Depletion of VESTAR inhibited ESCC-associated lymphangiogenesis and lymphatic metastasis. 33771898 VEAL2 LncRNA Homo sapiens Diabetic Retinopathy choroid tissue in eye and blood from patients Regulation(PRKCB2) qRT-PCR//RNA-seq//RIP//Western Blot Overexpression and knockdown of VEAL2 affected tubulogenesis and permeability in HUVECs. VEAL2 was differentially expressed in choroid tissue in eye and blood from patients with diabetic retinopathy, a disease where PRKCB2 is known to be hyperactivated. Further, VEAL2 could rescue the effects of PRKCB2-mediated turnover of endothelial junctional proteins thus reducing hyperpermeability in hyperglycemic HUVEC model of diabetic retinopathy. Yes Overexpression and knockdown of VEAL2 affected tubulogenesis and permeability in HUVECs. 34180064 VCAN-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[regulating p53] Flow Cytometry//qRT-PCR//RIP//Transwell Assay Herein, we observed a low level of VCAN-AS1 in normal gastric tissues through NCBI and UCSC, and that VCAN-AS1 upregulation in GC tissues was related to poor prognosis by TCGA. Our findings disclosed that VCAN-AS1 contributes to GC progression through interacting with eIF4A3 to downregulate TP53 expression, indicating that VCAN-AS1 is a novel therapeutic strategy for GC treatment. Furthermore, VCAN-AS1 was found markedly enhanced in GC tissues and cell lines, while its upregulation was related with clinical outcomes of GC patients. Yes Besides this, silencing VCAN-AS1 represses cell proliferation, migration, and invasion but enhances apoptosis. 31637706 VCAN-AS1 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[binding to microRNA-485-3p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay RT-qPCR data showed that circ-100219 and NTRK3 were highly expressed, whereas microRNA-485-3p was lowly expressed in breast cancer tissues than those of paracancer tissues. Overexpression of circ-10021 promotes the proliferative and migratory capacities of breast cancer cells by sponging microRNA-485-3p to upregulate the NTRK3 expression. Yes Knockdown of circ-100219 in MCF-7 and MDA-MB-231 cells inhibited their proliferative and migratory capacities. 31127997 VCAN-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-106a-5p-mediated STAT3/HIF-1α pathway) Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Transwell Assay Here, our results illustrate that VCAN-AS1 is overexpressed in BC tissues and cells, while miR-106a-5p was downregulated and negatively correlated with VCAN-AS1. Collectively, our data suggest that VCAN-AS1 is upregulated in breast cancer and promotes its progression by regulating the miR-106a-5p-mediated STAT3/HIF-1α pathway. In addition, high VCAN-AS1 expression and low miR-106a-5p expression were closely correlated with poor overall survival in BC patients. Yes Functional experiments confirmed that VCAN-AS1 overexpression notably accelerated BC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) and enhanced tumor cell growth while also suppressing cell apoptosis. However, overexpression of miR-106a-5p had the opposite effects. 34365889 VANGL1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cells Interaction(miR-145-5p to regulate SOX4 ) qRT-PCR//Western Blot The level of circ_VANGL1 and SOX4 was increased, while miR-145-5p was decreased in bladder cancer tissues and cells. Moreover, circ_VANGL1 acted as a sponge for miR-145-5p. In addition, miR-145-5p partially reversed the effects of miR-145-5p knockdown in T24 and J82 cells. SOX4 was a target of miR-145-5p and negatively regulated by miR-145-5p. Furthermore, miR-145-5p regulated SOX4 to affect cell progression in bladder cancer cells, including viability, apoptosis, and doxorubicin sensitivity. Yes Knockdown of circ_VANGL1 suppressed viability, while promoted apoptosis and increased doxorubicin sensitivity in bladder cancer cells. Besides, circ_VANGL1 suppressed tumor growth and enhanced the doxorubicin sensitivity in bladder cancer in vivo. 34258391 VANGL1 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC samples, PTC cells Interaction(miR-194/ZEB1/EMT Axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results revealed that circVANGL1 was significantly upregulated in human PTC samples. We further noted that circVANGL1 could interact with miR-194 directly in PTC, and serve as a ceRNA to regulate ZEB1 function. Moreover, miR-194 inhibition markedly abrogated the effects of circVANGL1 knockdown in PTC cells. Therefore, our results provide convincing evidence that circVANGL1 may exert oncogenic effects in PTC, partly via regulating the miR-194/ZEB1 axis. In addition, high circVANGL1 expression was closely associated with adverse clinical parameters of PTC patients. Yes Our in vitro experiments further indicated that the knockdown of circVANGL1 using siRNA obviously repressed migration, proliferation, EMT, and invasion of PTC cells, while opposite effects were induced by its overexpression. 35300347 USP30-AS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Interaction(miR-765.) CCK8//Luciferase Report Assay In colon cancer tissues, the USP30-AS1 downregulation and the miR-765 upregulation were observed, and there was a negative correlation between the USP30-AS1 expression level and the miR-765 expression level. The overexpression of USP30-AS1 dramatically suppressed colon cancer cellular processes, which was alleviated by miR-765. The downregulation of USP30-AS1 related to the malignant progression and served as an adverse prognostic indicator of colon cancer. Yes The overexpression of USP30-AS1 dramatically suppressed colon cancer cellular processes, which was alleviated by miR-765. 35260141 VIM-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms metastatic bladder cancer tissues and high-metastatic bladder cancer cell lines Interaction(miR-655/ZEB1 axis ) qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Transwell Assay Herein, we identified lncRNA VIM-AS1 as a highly- expressed lncRNA in bladder cancer, especially in metastatic bladder cancer tissues and high-metastatic bladder cancer cell lines. By acting as a ceRNA for miR-655, VIM-AS1 competed with ZEB1 for miR-655 binding, therefore eliminating the miR-655-mediated suppression of ZEB1, finally promoting EMT in both high- and low-metastatic bladder cancer cells and enhancing cancer cell metastasis. Yes By acting as a ceRNA for miR-655, VIM-AS1 competed with ZEB1 for miR-655 binding, therefore eliminating the miR-655-mediated suppression of ZEB1, finally promoting EMT in both high- and low-metastatic bladder cancer cells and enhancing cancer cell metastasis. 33902589 USP30-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML patients Interaction( USP30 and ANKRD13A) qRT-PCR//FISH According to results from bioinformatics analysis, lncRNA USP30-AS1 is highly expressed in AML and both the high expression of USP30-AS1 and low methylation level at Cg03124318 locus of USP30-AS1 gene promoter are associated with poor prognosis of AML. In summary, USP30-AS1 probably promotes AML cell survival by cis-regulating USP30 and ANKRD13A. Yes Results showed that USP30-AS1 promoted AML cell viability and inhibited apoptosis. 34694569 USP30-AS1 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Interaction( miR-299-3p/PTP4A1 axis) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Invasion Assay//Transwell Assay Patients with cervical cancer expressing high levels of USP30-AS1 exhibited shorter overall survival than those with low USP30-AS1 expression. In conclusion, the miR-299-3p/PTP4A1 axis is the downstream effector of USP30-AS1 in cervical cancer, forming the USP30-AS1/miR-299-3p/PTP4A1 pathway. Patients with cervical cancer expressing high levels of USP30-AS1 exhibited shorter overall survival than those with low USP30-AS1 expression. Yes . In vitro and in vivo experiments revealed that USP30-AS1 interference promoted cell apoptosis; restrained cell proliferation, migration and invasion in vitro, and hindered tumour growth in vivo. 33986866 USP30-AS1 LncRNA Homo sapiens Glioblastoma glioblastoma cells Expression(highly expressed) Western Blot//Transfection//Flow Cytometry//qRT-PCR//Bioinformatics Analysis we identified that USP30-AS1, an antisense lncRNA locating on the opposite strand of USP30 locus, is upregulated in human gliomas, particularly in high grade glioma. High level of USP30-AS1 is correlated with poor survival in both primary and recurrent glioma patients. USP30-AS1 regulates mitochondrial homeostasis and mitophagy in glioblastoma cells. Knockdown of USP30-AS1 decreases mitochondrial protein expression and mitochondrial mass, promotes mitochondrial uncoupler-induced mitophagy. However, USP30-AS1 does not regulate USP30 expression in a cis-regulatory manner. High level of USP30-AS1 is correlated with poor survival in both primary and recurrent glioma patients. Yes Knockdown of USP30-AS1 decreases mitochondrial protein expression and mitochondrial mass, promotes mitochondrial uncoupler-induced mitophagy. 34653676 USP2-AS1 LncRNA Homo sapiens Colonic Neoplasms COAD tissues regulation[Hippo/YAP1 signaling] RNA Pull-Down//Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Clinically, the USP2-AS1 levels were significantly elevated in COAD tissues and were positively correlated with tumor grade, size, and TNM stage.Collectively, these findings demonstrated that USP2-AS1 modulates and regulates Hippo signaling in COAD and could be a valuable therapeutic target. Clinically, the USP2-AS1 levels were significantly elevated in COAD tissues and were positively correlated with tumor grade, size, and TNM stage. Yes The loss- and gain-of function assays demonstrated that USP2-AS1 promotes cellular proliferation and metastasis of COAD cells. 33042447 USP2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular liver cancer tissues and cell lines Interaction(YBX1/HIF1α ) qRT-PCR We further confirmed that USP2-AS1 was significantly upregulated in liver cancer using FISH assay and that USP2-AS1 was associated with advanced liver cancer and increased tumor size. Our findings also suggest that USP2-AS1 could increase the protein level of HIF1α by enhancing YBX1 protein binding to HIF1α mRNA under hypoxia and the therapeutic effect of lenvatinib can be enhanced by combination with HIF1α inhibitors in liver cancer. Yes Furthermore, overexpression of USP2-AS1 under hypoxia dramatically increased HCC proliferation and clone formation, whereas the opposite results were observed after USP2-AS1 knockdown. We also found that overexpression of USP2-AS1 increased migration and invasion of HCC cells, while USP2-AS1 knockdown led to the opposite effect. In addition, USP2-AS1 knockdown can increase the efficacy of lenvatinib in our mice tumor xenograft model. 35692750 USP2-AS1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cell lines regulation[miR-520d-3p/KIAA1522 axis] RNA Pull-Down//Tunel//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay USP2-AS1 was obviously up-regulated in ovarian cancer tissues and cell lines.USP2-AS1 facilitated ovarian cancer progression via miR-520d-3p/KIAA1522 axis, implying USP2-AS1 as a new perspective for the treatment of ovarian cancer. Yes Inhibiting USP2-AS1 had anti-proliferation, pro-apoptosis, and anti-migration effects on ovarian cancer cells. 33122952 URRCC LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Regulation[ EGFL7/P-AKT/FOXO3 signaling ] qRT-PCR//Luciferase Report Assay//Microarray The microarray analysis and qRT-PCR identified a new lncRNA, URRCC, whose expression is upregulated in RCC samples and associated with poor prognosis, leading to promote ccRCC cell proliferation and invasion. Our data suggests that targeting this newly identified feed-back loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling may enhance the efficacy of existing therapy and potentially imparts a new avenue to develop more potent therapeutic approaches to suppress RCC progression. Yes The microarray analysis and qRT-PCR identified a new lncRNA, URRCC, whose expression is upregulated in RCC samples and associated with poor prognosis, leading to promote ccRCC cell proliferation and invasion. 30953521 URHC LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction( miR-5007-3p/DNAJB9) CCK8//qRT-PCR//Colony Formation Assay//FISH URHC silencing may inhibit the HCC cells' proliferation in vitro and in vivo. And miR-5007-3p could reverse the effect of URHC in HCC cells. These suggestive of lncRNA-URHC positively regulated the level of DNAJB9 by sponging miR-5007-3p. Yes URHC silencing may inhibit the HCC cells' proliferation in vitro and in vivo. And miR-5007-3p could reverse the effect of URHC in HCC cells. 34659430 VIM-AS1 LncRNA Homo sapiens Glioma cancer tissues regulation[VIM-AS1/miR-105-5p/WEE1 signaling ] CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay VIM-AS1 was elevated in cancer tissues, and high level of VIM-AS1 was positively correlated with poor overall survival.VIM-AS1/miR-105-5p/WEE1 signaling may be a promising target for glioma treatment. VIM-AS1 was elevated in cancer tissues, and high level of VIM-AS1 was positively correlated with poor overall survival. Yes Furthermore, the knockdown of VIM-AS1 significantly suppressed tumor growth in vivo. 32633376 VIM-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues,cell lines regulation[Wnt/β-catenin pathway ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The results of the present study demonstrated that VIM?AS1 was highly expressed in GC tissues and cells.Cumulatively, the present study demonstrated that VIM‑AS1 may promote cell proliferation, migration, invasion and epithelial‑mesenchymal transition by regulating FDZ1 and activating the Wnt/β‑catenin pathway in GC. In addition, VIM?AS1 expression was demonstrated to be closely related to the prognosis of patients with GC. Yes Notably, silencing VIM?AS1 inhibited the proliferation, migration and invasion, and enhanced apoptosis of AGS and HGC?27 cells. 33173977 UPK1A-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines interaction[sponging miR-1248] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Twenty dysregulated lncRNAs were detected in ESCC. Downregulation of UPK1A-AS1 was observed in ESCC tissues and cell lines. UPK1A-AS1 suppressed the proliferation, migration, and invasion of ESCC cells partially by sponging miR-1248. Yes Functionally, upregulation of UPK1A-AS1 suppressed the proliferation, migration, and invasion of ESCC cells. 32368143 VPS9D1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular tissue samples Interaction(HuR/CDK4 Axis) qRT-PCR//Colony Formation Assay//Western Blot VPS9D1-AS1 expression was significantly increased in HCC tissues in the analyzed databases and our independent tissue samples. Mechanistically, VPS9D1-AS1 was able to bind to the HuR protein and thereby influence the stability and expression of the CDK4 mRNA, thus impacting HCC cell proliferation. The VPS9D1-AS1/HuR/CDK4 signaling axis regulates HCC tumor cell oncogenic activity, highlighting this pathway as a promising therapeutic target. Elevated VPS9D1-AS1 expression was related to larger tumor size and more advanced tumor, node, metastasis (TNM) stage, and HCC patients expressing higher levels of this lncRNA exhibited poorer survival outcomes. Yes Knocking down VPS9D1-AS1 impaired the proliferative and colony formation activity of HepG2 cells while promoting their apoptotic death. Consistently, VPS9D1-AS1 silencing suppressed HCC tumor growth in vivo. 34558987 WDFY3-AS2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells regulation[miR-2355-5p/SOCS2 axis] Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining Here, WDFY3-AS2 was frequently down-regulated in ESCC tissues and cells, and its expression was correlated with TNM stage, lymph node metastasis and poor prognosis of ESCC patients. These findings suggest that WDFY3-AS2 may participate in ESCC development and progression, and may be a novel prognostic factor for ESCC patients, and thus targeting WDFY3-AS2/miR-2355-5p/SOCS2 signalling axis may be a novel therapeutic strategy for ESCC patients. Here, WDFY3-AS2 was frequently down-regulated in ESCC tissues and cells, and its expression was correlated with TNM stage, lymph node metastasis and poor prognosis of ESCC patients. Yes Moreover, WDFY3-AS2 down-regulation significantly promoted cell proliferation and invasion, whereas WDFY3-AS2 up-regulation markedly suppressed cell proliferation and invasion in ESCC EC9706 and TE1 cells, coupled with EMT phenotype alterations. 32536038 WASH5P LncRNA Homo sapiens Colorectal Neoplasms CRC cell lines and tissues Interaction( 740Y-P/WASH5P/PI3K/AKT) qRT-PCR//Western Blot Our present study found that WASH5P was significantly downregulated in CRC cell lines and tissues compared with normal controls. Meanwhile, the overexpression of WASH5P could significantly inhibit AKT activation via suppressing AKT phosphorylation. The treatment of PI3K/AKT (phosphatidlinositol 3-kinase /protein kinase B) signaling agonist 740Y-P rescued WASH5P-reduced AKT phosphorylation and abolished the inhibitory effects of WASH5P on cell viability, migration, and invasion. Moreover, 740Y-P restored the WASH5P-induced downregulation of p-AKT and vimentin and the upregulation of E-cadherin via Western blot. Yes The ectopic expression of WASH5P in CRC cells could significantly inhibit CRC cell proliferation, invasion, and migration. In addition, WASH5P could increase the expression of E-cadherin and decrease Vimentin expression. WASH5P-overexpressing CRC cells developed tumors more slowly in different mouse models. 35898869 WAC-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular TCGA Interaction(miR-320d/ARPP19 ) CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Eight lncRNAs (WAC-AS1, SNHG3, SNHG12, MSC-AS1, MIR210HG, PTOV1-AS1, AC145207.5 and AL031985.3) were used to established a prognostic model. WAC-AS1 affected the expression of several glycolysis-related genes (cAMP regulated phosphoprotein 19 (ARPP19), CHST12, MED24 and KIF2A) (P<0.01). Under hypoxic conditions, WAC-AS1 regulated ARPP19 by sponging miR-320d to promote glucose uptake and lactate production (P<0.01). Yes WAC-AS1 was found to affect glycolysis and promote tumor proliferation (P<0.01). 34527595 W42 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(DBN1) qRT-PCR//RNA Pull-Down//Colony Formation Assay//Transwell Assay LncRNA W42 expression was upregulated in HCC tissues and cells. LncRNA W42 directly bound to DBN1 and activated the downstream pathway. Yes Overexpression of lncRNA W42 notably promoted the proliferative and invasion of HCC, and inhibited cell apoptosis. 34092977 VPS9D1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC samples interaction[microRNA-532-3p,HMGA2 ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay VPS9D1-AS1 expression was upregulated in NSCLC; the extent of its upregulation significantly correlated with patients' adverse clinicopathological characteristics and shorter overall survival. Thus, VPS9D1-AS1 functions as a competing endogenous RNA that positively regulates HMGA2 expression by sponging miR-532-3p in NSCLC cells, suggesting that the VPS9D1-AS1-miR-532-3p-HMGA2 pathway can be a potential diagnostic and/or therapeutic target in NSCLC. VPS9D1-AS1 expression was upregulated in NSCLC; the extent of its upregulation significantly correlated with patients' adverse clinicopathological characteristics and shorter overall survival. Yes When VPS9D1-AS1 was knocked down in NSCLC cells, their proliferation, colony-forming capacity, migration, and invasiveness were lower, whereas their apoptosis rate was higher, compared to the control. VPS9D1-AS1 knockdown attenuated tumor growth of NSCLC cells in vivo. 31902794 VPS9D1-AS1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC clinical samples and cell lines Interaction(miR-142-5p ) RNA Pull-Down//FISH C190 was upregulated in both NSCLC clinical samples and cell lines. Activation of the EGFR pathway increased C190 expression through a MAPK/ERK-dependent mechanism. TargetScan and CircInteractome databases predicted that C190 targets CDKs by sponging miR-142-5p. Yes Transient and stable overexpression of C190 induced ERK1/2 phosphorylation, proliferation, and migration in vitro and xenograft tumor growth in vivo. CRISPR/Cas13a-mediated knockdown of C190 decreased proliferation and migration of NSCLC cells in vitro and suppressed tumor growth in vivo. 34753774 VPS9D1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues, cell lines and plasma Regulation(Wnt/β-catenin signaling pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//RNA-seq//Invasion Assay Compared with controls, lncRNA VPS9D1-AS1 was highly expressed in ESCC tissues, cell lines and plasma. VPS9D1-AS1 silencing downregulated the Wnt/β-catenin signaling pathways by acting on key proteins such as β-catenin and c-Myc. However, the expressions of these proteins increased after the addition of pathway agonist CT99021. VPS9D1-AS1 upregulation significantly correlated with the histopathological grade and clinical stage of ESCC. Analyses revealed poor prognosis in ESCC patients with high VPS9D1-AS1 expression. Yes VPS9D1-AS1 knockdown led to the inhibition of tumor proliferation, migration, and invasion in vivo and vitro. 34659577 VPS9D1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CD8+ T cells Regulation(TGF-β/ISG signaling ) RNA Pull-Down//Northern Blot//Western Blot//CCK8//qRT-PCR//IHC//ChIP We show that high expression of VPS9D1-AS1 was negatively associated with T lymphocyte infiltration in two independent cohorts of CRC.VPS9D1-AS1 served as a scaffolding lncRNA by binding with ribosome protein S3 (RPS3) to increase the translation of TGF-β, TGFBR1, and SMAD1/5/9. Yes VPS9D1-AS1 knockout downregulated OAS1, an ISG gene, which further reduced IFNAR1 levels in tumor cells. Conversely, tumor cells overexpressing VPS9D1-AS1 were resistant to CD8+ T cell killing and lowered IFNAR1 expression in CD8+ T cells. In a conditional overexpression mouse model, VPS9D1-AS1 enhanced tumorigenesis and suppressed the infiltration of CD8+ T cells. Treating tumor-bearing mice with antisense oligonucleotide drugs targeting VPS9D1-AS1 significantly suppressed tumor growth. 36458816 VPS9D1-AS1 LncRNA Homo sapiens Endometrial Neoplasms tissues and cells of UCEC Interaction(miR-520a-5p/BIRC5 ) CCK8//qRT-PCR//Western Blot Our findings suggested VPS9D1-AS1 gene expression was up-regulated in both tissues as well as cells of UCEC. Mechanistically, it was verified that VPS9D1-AS1 targeted BIRC5 and caused miR-520a-5p sponging. Inhibitor of miR-520-5p markedly reversed the anti-tumor effects of VPS9D1-AS1 knockdown or BIRC5 knockdown on UCEC progression. Yes . VPS9D1-AS1 knockdown suppressed migration, invasion, epithelial-mesenchymal transition (EMT) along with proliferation of UCEC cells, caused in vitro cell apoptosis initiation, and in vivo reduction of tumor growth. 35619019 VIRMA LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[KIAA1429-GATA3] qRT-PCR//RNA-seq//IHC//Western Blot KIAA1429 was considerably upregulated in HCC tissues.Our study proposed a complex KIAA1429-GATA3 regulatory model based on m6A modification and provided insights into the epi-transcriptomic dysregulation in hepatocarcinogenesis and metastasis. Yes MeRIP-seq, RIP-seq and RNA-seq 31856849 VPS9D1-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Regulation[miR-184/c-Myc axis] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay In the present study, we demonstrated that lncRNA MYU is significantly upregulated in prostate cancer tissues.Thus, this study demonstrated that lncRNA MYU functions as an oncogene in prostate cancer at least in part through the miR-184/c-Myc axis, and may serve as a potential diagnostic biomarker and therapeutic target. Yes MYU knockdown impaired prostate cancer cell growth and migration as shown from cell viability, colony formation, Transwell and wound healing assays.In contrast, MYU overexpression displayed opposite effects. 30132573 VPS9D1-AS1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Interaction[sponging miR-4739 to upregulate MEF2D] RNA Pull-Down//ChIP//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay The expression of VPS9D1-AS1 was conspicuously upregulated in PCa tissues and cells. Furthermore, VPS9D1-AS1/MEF2D could sponge with miR-4739. VPS9D1-AS1/MEF2D and miR-4739 were inversely correlated in tumor cells. And the expression of miR-4739 is markedly downregulated in PCa, meanwhile, that of MEF2D exhibited the opposite tendency. However, MEF2D was positively regulated by VPS9D1-AS1. Moreover, MEF2D upregulation offset the suppressive effects of VPS9D1-AS1 deficiency on cell proliferation, migration and invasion in PCa. Additionally, ZEB1 contained the binding sites of VPS9D1-AS1 promoter, and there existed positive relation between them. Yes And absence of VPS9D1-AS1 inhibited cell proliferation, migration and invasion, and promoted cell apoptosis in PCa. In addition, VPS9D1-AS1 overexpression led to opposite results. 31918265 VPS9D1-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC cells and tissues Interaction(miR-377-3p/SGK1) RNA Pull-Down//Western Blot//EdU Staining//Tunel//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//IHC//Invasion Assay//Transwell Assay VPS9D1-AS1 was upregulated in EC cells and tissues. Mechanically, VPS9D1-AS1 was a molecular sponge of miR-377-3p, and overexpression of miR-377-3p reversed VPS9D1-AS1-induced EC cells proliferation, invasion, and EMT. Moreover, SGK1 was confirmed to bind with miR-377-3p. Furthermore, overexpression of SGK1 alleviated sh-VPS9D1-AS1-caused effects on EC cells. High level of VPS9D1-AS1 and SGK1, or low miR-377-3p expression predicted a poor prognosis. The expression of the three genes was correlated with lymph node metastasis, pathological stage, and International Federation of Gynecology and Obstetrics (FIGO) stage, but not associated with age, ER, and PR expression. Yes Interference of VPS9D1-AS1 inhibited growth, invasion, and EMT of EC cells. Interestingly, knockdown of VPS9D1-AS1 suppressed EC tumor growth in mice. VPS9D1-AS1 promoted cell invasion, proliferation, and EMT via modulating miR-377-3p/SGK1 axis, which provided new options for therapeutic strategies of EC. 36245426 VPS9D1-AS1 LncRNA Homo sapiens Colonic Neoplasms COAD tissues and cell lines Interaction(miR-324-5p/ITGA2 axis) Transfection//Wound Healing Assay//Invasion Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining VPS9D1-AS1 was found to be upregulated in COAD tissues and cell lines. In addition, we have demonstrated that miR-324-5p targets VPS9D1-AS1 and ITGA2 3'-UTR, and miR-324-5p silencing or forced ITGA2 expression attenuated the effect of VPS9D1-AS1 knockdown. Yes VPS9D1-AS1 knockdown inhibited the COAD cell proliferation, migration and invasion and increased the apoptosis rate 35273698 VPS18 CircRNA Homo sapiens Glioblastoma glioblastoma tissues and cells Interaction(miR-1229-3p/BCAT1 Axis) RNA Pull-Down//IHC//Western Blot//Transfection//Tube Formation Assay//Flow Cytometry//qRT-PCR//RIP//PCR//IP//Transwell Assay//IF CircVPS18 and BCAT1 were highly expressed while miR-1229-3p was lowly expressed in glioblastoma tissues and cells. Moreover, miR-1229-3p could be targeted by circVPS18; inhibition of miR-1229-3p could invert the suppressive effect of circVPS18 knockdown on glioblastoma tumorigenesis. Furthermore, BCAT1 was a target of miR-1229-3p; functionally, BCAT1 overexpression could reverse the inhibitory effects of miR-1229-3p upregulation on glioblastoma cell malignant phenotypes. Moreover, we also verified that circVPS18A could regulate BCAT1 expression by sponging miR-1229-3p. Additionally, circVPS18 silencing also restrained tumor growth and metastasis in vivo. CircVPS18 accelerated glioblastoma progression by miR-1229-3p/BCAT1 axis, providing a potential therapeutic target for glioblastoma. Yes CircVPS18 knockdown inhibited glioblastoma progression by inhibiting cell proliferation, migration, invasion, and angiogenesis, and promoting cell apoptosis. 35776379 VPS13B-DT LncRNA Homo sapiens Stomach Neoplasms GC tissues and normal adjacent tissues,cell lines(GES-1,AGS) Regulation[IL-11/STAT3 signaling ] Western Blot//Migration Assay//CCK8//qRT-PCR//FISH//RNA-seq//ELISA OLC8 was significantly overexpressed in gastric cancer specimens and cell lines. Yes In vitro experiments showed that OLC8 facilitated migration and viability of MKN1 and AGS cells. 31273847 Vof-16 LncRNA Homo sapiens Spinal Cord Injuries PC12 cell Regulation Western Blot//Transfection//qRT-PCR//FISH//migration assay//Cell Proliferation Assay//Bioinformatics Analysis These findings suggested that lncRNA Vof-16 is associated with the regulation of inflammation and apoptosis. The inhibition of lncRNA Vof-16 may be useful for promoting nerve regeneration and functional recovery after spinal cord injury. Yes The overexpression of lncRNA Vof-16 inhibited PC12 cell survival, proliferation, migration, and neurite extension, whereas lncRNA Vof-16 knockdown lentiviral vector resulted in the opposite effects in PC12 cells.Western blot assay results showed that the overexpression of lncRNA Vof-16 increased the protein expression levels of interleukin 6, tumor necrosis factor-α, and Caspase-3 and decreased Bcl-2 expression levels in PC12 cells. 34100459 VMA21 CircRNA Rattus norvegicus Lung Injury lung tissue and lipopolysaccharide (LPS)-treated BEAS-2B Interaction(microRNA-497-5p/CD2) TUNEL//Western Blot//Transfection//qPCR//Tunel//Flow Cytometry//RIP//MTT//PCR//IP//ELISA//IF The results manifested circVMA21 and CD2-associated protein (CD2AP) were down-regulated in lung tissue and lipopolysaccharide (LPS)-treated BEAS-2B, while microRNA (miR)-497-5p was up-regulated. In conclusion, this work showed circVMA21 improved LI in sepsis rats by targeting miR-497-5p/CD2AP axis, suggesting that circVMA21 may be a novel therapeutic target for sepsis-induced LI. Yes Overexpression of circVMA21 ameliorated these phenomena. In addition, LPS-induced apoptosis and inflammation of BEAS-2B cells was improved via overexpression of circVMA21, while overexpression of miR-497-5P was opposite. Apoptosis, inflammation, and oxidative damage of BEAS-2B cells were aggravated via knockdown of circVMA21, but it was reversed by knockdown of miR-497-5p or overexpression of CD2AP. 35172672 UPLA1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissue Expression[highly expressed] RNA Pull-Down//Western Blot//ISH//Wound Healing Assay//Flow Cytometry//qRT-PCR//FISH//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our results showed that UPLA1 is highly expressed and regulates important biological functions in lung adenocarcinoma. Furthermore, in situ hybridisation assay results showed that UPLA1 was closely related to the prognosis and tumour, node, metastasis (TNM) stage of lung adenocarcinoma. Yes In vitro experiments revealed that UPLA1 promoted the migration, invasion, and proliferation abilities, and is related to cell cycle arrest, in lung adenocarcinoma cells. Moreover, the upregulation of UPLA1 significantly improved the growth of tumours in vivo. 33221813 UPF1 LncRNA Homo sapiens Glioblastoma glioma tissues and cells Regulation[UPF1-Linc-00313-miR-342-3p/miR-485-5p-Zic4-SHCBP1 pathway ] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Microarray UPF1 and Linc-00313 were both upregulated in glioma tissues and cells.The study is the first to prove that the UPF1-Linc-00313-miR-342-3p/miR-485-5p-Zic4-SHCBP1 pathway forms a positive-feedback loop and regulates the biological behaviors of U87 and U251 cells, which might provide a new therapeutic target for glioma. Yes Knockdown of UPF1 or Linc-00313 significantly inhibited malignant biological behaviors of glioma cells by regulating miR-342-3p and miR-485-5p, which are downregulated and functioned as tumor suppressors in glioma. 31427569 hsa_circ_0061587 CircRNA Homo sapiens Neurofibromatosis 1 cell lines Interaction(miR-485-5p/RUNX1 and ANXA11) RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In our study, RT-qPCR was applied to analyze circ_0061,587 expression and we noticed that circ_0061,587 expression was overtly elevated in human NF1-associated malignant peripheral nerve sheath tumor (MPNST) cell lines. In addition, mechanism assays were implemented to unveil the possible regulatory mechanism behind circ_0061,587. As a result, circ_0061,587 sequestered microRNA-485-5p (miR-485-5p) to modulate the expression of RUNX family transcription factor 1 (RUNX1) and annexin A11 (ANXA11). Finally, rescue experiments confirmed that circ_0061,587 boosted the malignant behaviors of human NF1-associated MPNST cells through up-regulating RUNX1 and ANXA11. Yes Meanwhile, the results of loss-of-function assays revealed that silencing of circ_0061,587 hampered the proliferation, migration, and invasion but stimulated the apoptosis of human NF1-associated MPNST cells. 35181394 hsa_circ_0038467 CircRNA Homo sapiens Pneumonia neonatal pneumonia serum specimens and 16HBE cells Interaction(miR-545-3p/TRAF1 axis) qRT-PCR Circ_0038467 was upregulated in neonatal pneumonia serum specimens and LPS-triggered 16HBE cells. Meanwhile, miR-545-3p was targeted by circ_0038467, and circ_0038467 could modulate LPS-treated 16HBE cell injury through absorbing miR-545-3p. Furthermore, circ_0038467 controlled TRAF1 level via segregating miR-545-3p. Moreover, TRAF1 overexpression relieved the suppressive impact of circ_0038467 silence in LPS-triggered 16HBE cell detriment. Yes LPS administration restrained 16HBE cell proliferation and promoted apoptosis and inflammation, whereas circ_0038467 silence recovered these influences. 36216207 UCC LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-143-3p/SOX5 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qPCR//RIP//MTT//Luciferase Report Assay//IHC LncRNA UCC was highly expressed in both NSCLC tissues and cells. In addition, a dual-luciferase reporter system and RIP assays showed that UCC specifically bound to miR-143-3p and acted as a sponge of miR-143-3p in NSCLC cells. The miR-143-3p inhibitor rescued the inhibitory effect of sh-UCC on the proliferation of NSCLC cells. Moreover, miR-143-3p and UCC showed opposite effects on the expression of SOX5, which promoted EMT in NSCLC cells. Yes Knockdown of UCC expression suppressed the proliferation of NSCLC cells. In addition, in a mouse model, knockdown of UCC expression alleviated EMT and NSCLC progression in vivo, which was consistent with the in vitro results. 33824420 circZNF609 CircRNA Homo sapiens Melanoma melanoma tissues and cells Regulation(RAC1 mRNA) In Vivo Experiment//RNA Pull-Down//Transfection//Wound Healing Assay//qRT-PCR//circRNA-seq//FISH//RIP//Microarray//Transwell Assay//IF Our findings revealed that circZNF609 plays a vital role in the metastasis of acral and cutaneous melanoma through the circRNF609-FMRP-RAC1 axis and indicated that circZNF609 regulates the stability of RAC1 mRNA by combining with FMRP, which might provide insight into melanoma pathogenesis and a new potential target for treatment of melanoma. circZNF609 was stably expressed at low levels in melanoma tissues and cells and was negatively correlated with Breslow depth, clinical stage and prognosis of melanoma patients. Yes circZNF609 inhibited metastasis of acral and cutaneous melanoma in vivo and in vitro. Mechanistically, circZNF609 promoted the binding of FMRP protein and RAC1 mRNA, thereby enhancing the inhibitory effect of FMRP protein on the stability of RAC1 mRNA and ultimately inhibiting melanoma metastasis. 35534866 UCA1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Regulation[miR-203/ZEB2 axis] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Microarray In this study, we found that UCA1 was aberrantly elevated in gastric cancer tissues, and was significantly associated with lymph node metastasis and TNM stage.To explore function of UCA1-miR-203-ZEB2 axis may provide an informative biomarker of malignancy and a highly selective anti-GC therapeutic target. In this study, we found that UCA1 was aberrantly elevated in gastric cancer tissues, and was significantly associated with lymph node metastasis and TNM stage. Yes In vivo and in vitro, enforced UCA1 level promoted cell migration and invasion of GC cell. Depleted UCA1 expression level attenuated the ability of cell migration and invasion in GC. 30464170 UCA1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[PDL1] qRT-PCR//MTT//Transwell Assay UCA1 promoted GC cells proliferation and migration, and inhibit apoptosis. UCA1 repressed miR-26a/b, miR-193a and miR-214 expression through direct interaction and then up-regulated the expression of PDL1. UCA1-KO GC cells could induce a higher IFNγ expression when co-cultured with peripheral blood mononuclear cells (PBMCs), and have a lower survival rate when co-cultured with cytokine-induced killer (CIK) cells in vitro. UCA1-KO GC cells formed smaller tumors, had higher miR-26a, -26b, -193a and - 214 level, reduced cell proliferation and increased apoptosis in xenograft mouse model. Yes UCA1-KO GC cells formed smaller tumors, had higher miR-26a, -26b, -193a and - 214 level, reduced cell proliferation and increased apoptosis in xenograft mouse model. 31272462 hsa_circ_0001020 CircRNA Homo sapiens Venous Thrombosis DVT patients and mouse model Interaction(miR-29c-3p/MDM2 ) In Vivo Experiment//RNA Pull-Down//Transfection//Tube Formation Assay//qPCR//Immunoblotting//Migration Assay//FISH//RIP//Luciferase Report Assay//Invasion Assay//IF Hsa_circ_0001020 and MDM2 upregulated, whereas miR-29c-3p downregulated in DVT patients and mouse model. Hsa_circ_0001020 sponged miR-29c-3p to promote MDM2 expression thus inhibited EPC migration, invasion and tube formation. And the function of hsa_circ_0001020 and regulatory mechanism was demonstrated by the lose-function of hsa_circ_0001020 and rescue experiment. In DVT mice, hsa_circ_0001020 knockdown suppressed thrombosis and promoted homing ability of EPCs into thrombi. Yes Hsa_circ_0001020 sponged miR-29c-3p to promote MDM2 expression thus inhibited EPC migration, invasion and tube formation. And the function of hsa_circ_0001020 and regulatory mechanism was demonstrated by the lose-function of hsa_circ_0001020 and rescue experiment. In DVT mice, hsa_circ_0001020 knockdown suppressed thrombosis and promoted homing ability of EPCs into thrombi. 35066205 UCA1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Flow Cytometry//Migration Assay RT-PCR results showed that the expression levels of UCA1 in GC tissues were significantly higher compared to those in adjacent normal specimens. In GC patients, plasma expression of UCA1 was significantly up-regulated compared to that in healthy controls (1.417 ± 0.106 vs. 0.223 ± 0.030, p < 0.0001). Plasma UCA1 was significantly correlated with tumor differentiation (p < 0.05), T stage (p < 0.001) and lymph node metastasis (p < 0.001). Plasma UCA1 expression (AUC = 0.883) in post-surgery samples was significantly decreased compared to the expression level of pre-surgery patients (1.403 ± 1.329 versus 0.712 ± 0.944, p < 0.01). Yes  Down-regulation of UCA1 inhibited the proliferation, migration, and apoptosis of GC cells.  31710437 UCA1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[Repressing p21 and SPRY1] Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//RIP//MTT//Invasion Assay//ChIP Next, we used qRT-PCR to detect UCA1 expression in 60 paired gastric cancer samples and adjacent normal tissues. As shown in Figure 2A, UCA1 was significantly overexpressed in 60 paired GC tissues. In our study, we found that upregulated UCA1 is associated with poor prognosis in gastric cancer patients. Yes Further experiments revealed that UCA1 knockdown significantly repressed the proliferation and migration both in vitro and in vivo. 31689615 UCA1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer cell lines or tissues Interaction(miR-145/MYO6 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//IHC UCA1 expression was higher but miR-145 expression was lower in gastric cancer cell lines or tissues, compared to the adjacent normal cell line or normal tissues. Mechanistically, UCA1 could bind directly to miR-145, and MYO6 was found to be a downstream target gene of miR-145. miR-145 mimics or MYO6 siRNAs could partly reverse the effect of UCA1 on gastric cancer cells. Yes Function analysis verified that UCA1 promoted cell proliferation and inhibited cell apoptosis in the gastric cancer cells in vitro and in vivo. 34238213 hsa_circ_0047078 CircRNA Homo sapiens Carcinoma, Pancreatic Ductal tissues and cell lines Interaction(miR-11181/CXCL12, MCAM and RGS16) Western Blot//Transfection//Flow Cytometry//qRT-PCR//Microarray//Cell Proliferation Assay//Invasion Assay//Transwell Assay Competing endogenous RNA (ceRNA) microarray revealed that circ-0047078 was highly expressed in pancreatic ductal adenocarcinoma (PDAC) tissues compared with adjacent normal tissues, and the differential expression was further confirmed by PCR in both tissues and cell lines. Cell functional assays including cell counting kit-8 (CCK-8) assay, transwell invasion assay, flow cytometry and caspase activity assay demonstrated that circ-0047078 was positively correlated with the proliferation and invasion but negatively correlated with the apoptosis of CFPAC-1 cells. Circ-0047078 knockdown led to miR-11181, CXCL12 and MCAM downregulation and RGS16 upregulation, and the effect of circ-0047078 knockdown on CFPAC-1 cell behavior change can be reversed by miR-11181 mimic. In conclusion, circ-0047078 plays a role in promoting PDAC via miR-11181 and then via CXCL12, MCAM and RGS16. Moreover, clinicopathological analysis indicated that circ-0047078 expression level was positively correlated with lymphatic metastasis and perineural invasion. Yes Cell functional assays including cell counting kit-8 (CCK-8) assay, transwell invasion assay, flow cytometry and caspase activity assay demonstrated that circ-0047078 was positively correlated with the proliferation and invasion but negatively correlated with the apoptosis of CFPAC-1 cells. Circ-0047078 knockdown led to miR-11181, CXCL12 and MCAM downregulation and RGS16 upregulation, and the effect of circ-0047078 knockdown on CFPAC-1 cell behavior change can be reversed by miR-11181 mimic. 35771357 circCERS6 CircRNA Mus musculus Carcinoma, Ovarian Epithelial EOC tissues and cell lines. Regulation(miR-630/RASSF8) qRT-PCR//Luciferase Report Assay//IHC CircCERS6 expression was markedly reduced in EOC tissues and cell lines. CircCERS6 overexpression hampered the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of EOC cells. CircCERS6 directly interacted with miR-630. miR-630 expression was up-regulated in EOC tissues and cell lines. CircCERS6 overexpression-induced anti-tumor effects in EOC were largely reversed by the overexpression of miR-630. RASSF8 was a direct target of miR-630. RASSF8 level was decreased in EOC tissues and cell lines. CircCERS6 up-regulated RASSF8 expression by acting as a molecular sponge for miR-630 in EOC cells. CircCERS6 overexpression-mediated suppressive effects in EOC cells were largely overturned by the silence of RASSF8. CircCERS6 overexpression blocked tumor growth in vivo. CircCERS6 overexpression hampered the proliferation, migration, invasion, and EMT of EOC cells by up-regulating RASSF8 via sponging miR-630. Yes CircCERS6 overexpression hampered the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of EOC cells. 35676548 UCA1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(METTL14-miR-375-SOX12) CCK8//qRT-PCR//RIP//Flow Cytometry//Transwell Assay It was found the elevated lncRNA UCA1 expression levels serve as a risk factor of poor prognosis in breast cancer. Furthermore, METTL14 was observed to mediate the low miR-375 expression through m6A modification, leading to increased SOX12 expression levels in breast cancer. Altogether, findings obtained in our study indicated that silencing lncRNA UCA1 curbed the progression of breast cancer through the METTL14-miR-375-SOX12 axis. It was found the elevated lncRNA UCA1 expression levels serve as a risk factor of poor prognosis in breast cancer. Yes Meanwhile, silencing lncRNA UCA1 could inhibit the proliferation and invasion, but promote apoptosis of breast cancer cells by reducing the DNA methylation of METTL14 and augmenting its expression. 35022519 circCDR1as CircRNA Homo sapiens Lung Neoplasms lung cancer cells Regulation(SRSF1) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Co-IP//FISH//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay The lower expression of CircCDR1as reduced the adverse progression of lung cancer cells after PM2.5 treatment; the lower expression of circCDR1as impaired the growth size and metastatic ability of lung cancer cells in mouse tumour models. Mechanistically, circCDR1as specifically bound to serine/arginine-rich splicing Factor 1 (SRSF1) and affected the splicing of vascular endothelial growth factor-A (VEGFA) by SRSF1. Furthermore, circCDR1as affected SRSF1 function by regulating PARK2-mediated SRSF1 ubiquitination, protein production and degradation. CircCDR1as also affected C-myc and cyclin D1 expression by regulating SRSF1 and affecting the wnt/β-catenin signalling pathway, ultimately promoting malignant behavior and inhibiting the apoptosis of lung cancer cells, thereby causing PM2.5-induced lung cancer development. Yes The lower expression of CircCDR1as reduced the adverse progression of lung cancer cells after PM2.5 treatment; the lower expression of circCDR1as impaired the growth size and metastatic ability of lung cancer cells in mouse tumour models. 36508830 UCA1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Regulation(PKM2/mTOR ) qRT-PCR//Cell Viability Assay//Western Blot Mechanistically, PKM2 knockdown suppressed the effects of UCA1 on viability and glycolysis of NSCLC cells and inhibition of the mTOR pathway suppressed the effects of UCA1 on viability, glycolysis, and PKM2 expression in NSCLC cells. In conclusion, knockdown of UCA1 inhibited viability and glycolysis by suppressing PKM2 expression maybe through the mTOR pathway in NSCLC cells, providing a novel insight into the molecular mechanism of UCA1 involved in the regulation of glucose metabolism in NSCLC cells. Yes Our results showed that knockdown of UCA1 inhibited the viability of NSCLC cells. UCA1 silencing suppressed glycolysis of NSCLC cells by reducing the glucose consumption and lactate production. Additionally, knockdown of UCA1 suppressed PKM2 expression and the mTOR pathway in NSCLC cells. 35540445 circNR3C1 CircRNA Homo sapiens RNA, Circular GC cells and tissues Regulation( AKT/mTOR) Western Blot//Migration Assay//qRT-PCR//Cell Proliferation Assay//Transwell Assay circNR3C1 was markedly lowly expressed in GC cells and tissues. circNR3C1 downregulated mTOR and AKT in GC cells. In addition, induction of the AKT activator could reverse the attenuated proliferative and migratory potentials in GC cells overexpressing circNR3C1. On the contrary, induction of the AKT inhibitor reversed the stimulated malignant phenotypes of GC with circNR3C1 knockdown. circNR3C1 inhibits GC to proliferate and migrate by inactivating the AKT/mTOR signaling. It is also closely linked to GC metastasis. A low level of circNR3C1 predicted high incidences of lymphatic or distant metastasis of GC. Yes Knockdown of circNR3C1 enhanced proliferation and migration abilities in BGC-823 cells, whereas overexpression of circNR3C1 yielded the opposite results in AGS cells. 35340241 UCA1 LncRNA Homo sapiens Lung Neoplasms cell lines Expression[highly expressed] CCK8//qRT-PCR//Wound Healing Assay It was observed that lncRNA UCA1 was significantly (p < 0.05) upregulated in all the lung cancer cell lines. Yes The results showed that suppression of lncRNA UCA1 significantly (p < 0.05) reduced the viability of NCI-H23 cancer cells via induction of the apoptosis. 30468471 circFLI1 CircRNA Homo sapiens colon carcinoma CC patients' tumors and cells Interaction(miR-197-3p/DKC1) Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay//Transwell Assay In terms of expression status, circ-FLI1 was abnormally upregulated in CC patients' tumors and cells, paralleled with DKC1 upregulation and miR-197-3p downregulation. Furthermore, there were counteractive effects between circ-FLI1 silencing and miR-197-3p depletion, miR-197-3p overexpression and DKC1 restoration on regulating CC cell functions and L-OHP resistance Yes Functionally, the colony formation assay, MTS method, fluorescence-activated cell sorting method, cell cycle and apoptosis assays, and transwell assays were performed, and the results revealed that interfering circ-FLI1 and re-expressing miR-197-3p could restrict colony formation, cell viability, cell cycle progression, and migration/invasion of CC cells with apoptosis rate elevation; besides, they promoted oxaliplatin (L-OHP)-induced cell viability inhibition. 35647294 UCA1 LncRNA Homo sapiens Colorectal Neoplasms cell lines(SW620 and HT29) Interaction[up-regulate the WISP2/β-catenin pathway] Western Blot//Tunel//CCK8//qRT-PCR//Luciferase Report Assay Herein, we found that UCA1 was aberrantly upregulated in two CRC cell lines (SW620 and HT29) compared to colorectal cell CCD-18Co. Furthermore, UCA1 could act as an endogenous sponge by directly interacting with miR-185-5p and downregulation miR-185-5p expression. In addition, UCA1 could reverse the inhibitory effect of miR-185-5p on the growth and autophagy of CRC cells, which might be involved in the derepression of member 1 (WNT1)-inducible signaling pathway protein 2 (WISP2, a target gene of miR-185-5p) expression and the activation of the WISP2/β-catenin signaling pathway. In vivo, the present study elucidates a novel UCA1-miR-185-5p-WISP2-Wnt/β-catenin axis in CRC, which may help us to understand the pathogenesis and the feasibility of lncRNA-directed diagnosis and therapy of CRC. Yes UCA1 knockdown inhibited the apoptosis, growth and autophagy of CRC cell lines in vitro. 35519332 UCA1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[miR-143/MYO6 Axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay This study showed that UCA1 was upregulated in CRC tissues and functioned as an oncogene in CRC.Mechanistically, UCA1 was identified as a miR-143 sponge. We also found that MYO6 was a direct target of miR-1205, which functioned as an oncogene in CRC. Moreover, UCA was also upregulated in the serum exosomes of CRC patients and could transfer UCA1 to CRC cells to increase their abilities of cell proliferation and migration. In conclusion, these data suggest that UCA1 could be an oncogene for CRC and may serve as a candidate target for new therapies in human CRC. Yes Loss-of-function investigations showed that inhibition of UCA1 suppressed CRC cell proliferation and metastasis in vivo and in vitro. 31955010 UCID LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[DHX9, CDK6 ] RNA Pull-Down//CCK8//Luciferase Report Assay//BrdU//Cell Cycle Assay//Colony Formation Assay Lnc-UCID was up-regulated in hepatocellular carcinoma (HCC), and a higher lnc-UCID level was correlated with shorter recurrence-free survival of HCC patients. Up-regulation of lnc-UCID, which may result from amplification of its gene locus and down-regulation of miR-148a, can promote HCC growth by preventing the interaction of DHX9 with CDK6 and subsequently enhancing CDK6 expression. Lnc-UCID was up-regulated in hepatocellular carcinoma (HCC), and a higher lnc-UCID level was correlated with shorter recurrence-free survival of HCC patients. Yes Both gain-of-function and loss-of function studies revealed that lnc-UCID enhanced cyclin-dependent kinase 6 (CDK6) expression and thereby promoted G1/S transition and cell proliferation. Studies from mouse xenograft models revealed that tumors derived from lnc-UCID-silenced HCC cells had a much smaller size than those from control cells, and intratumoral injection of lnc-UCID small interfering RNA suppressed xenograft growth. 30865310 UFC1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissues, serum regulation[PTEN ,EZH2] ChIP//Western Blot//qRT-PCR//RIP//Colony Formation Assay//Transwell Assay UFC1 expression was upregulated in tumor tissues, serum, and serum exosomes of NSCLC patients and high level of UFC1 was associated with tumor infiltration. Moreover, Exosome-transmitted UFC1 promotes NSCLC progression by inhibiting PTEN expression via EZH2-mediated epigenetic silencing. Yes UFC1 knockdown inhibited NSCLC cell proliferation, migration and invasion while promoted cell cycle arrest and apoptosis. UFC1 overexpression led to the opposite effects. 32242003 Unigene56159 LncRNA Homo sapiens Glioblastoma GBM samples and adjacent normal brain samples Interaction[miR‑194‑5p] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Among the differentially expressed lncRNAs, Unigene56159 expression levels were the highest in GBM, demonstrating markedly upregulated expression levels compared with normal brain tissue.These findings suggested that Unigene56159 may serve an oncogenic role in GBM and may promote disease progression through interacting with miR‑194‑5p. This higher expression level of Unigene56159 was positively correlated with poor overall survival in patients with GBM. Yes Small interfering RNA (siRNA) was used to silence the expression of Unigene56159 and inhibit the proliferation and invasion of GBM cell lines by MTT and Transwell assay. 31789416 UNC5B-AS1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissue interaction[binding to caspase-9] CCK8//qRT-PCR//Flow Cytometry//EdU Staining//Transwell Assay QRT-PCR results suggested that UNC5B-AS1 expression in PCa tissue samples was remarkably higher than in adjacent ones, with a statistically significant difference. In addition, UNC5B-AS1 was able to accelerate the malignant progression of PCa by modulating caspase-9 expression. Compared with patients with low expression of UNC5B-AS1, patients with highly-expressed UNC5B-AS1 had a higher incidence of distant metastasis and more advanced pathological stage. Yes At the same time, proliferation and invasion, as well as migration ability of cells in sh-UNC5B-AS1 group, was conspicuously attenuated while cell apoptosis ability was conversely enhanced. 32196578 UNC5B-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[AKT/mTOR pathway] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay n breast cancer tissues, UASR1 was upregulated. Ectopic expression of UASR1 promoted proliferation and clonogenic growth of breast cancer cells MCF7 and MDA-MB-231. The migration of these cells also increased as demonstrated by wound healing and transwell assays. In contrast, silencing of UASR1 suppressed cell proliferation and migration. Yes n breast cancer tissues, UASR1 was upregulated. Ectopic expression of UASR1 promoted proliferation and clonogenic growth of breast cancer cells MCF7 and MDA-MB-231. The migration of these cells also increased as demonstrated by wound healing and transwell assays. In contrast, silencing of UASR1 suppressed cell proliferation and migration. 31205563 UNC5B-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cells regulation[miR-218-5p expression] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay The expression of UNC5B-AS1 in lung cancer tissues and cells was significantly higher than that in adjacent tissues and bronchial epithelial cells (P＜0.05). lncRNA UNC5B-AS1 promotes adhesion, invasion and migration of lung cancer cells through targeted regulation of miR-218-5p expression, and its mechanism may be related to the promotion of EMT. Yes Down-regulation of UNC5B-AS1 expression inhibited adhesion, invasion and migration of A549 cells (P＜0.05). 33719270 circNfix CircRNA Mus musculus Cardiomegaly Ang II-treated cardiomyocytes and TAC mouse Interaction(miR-145-5p/ATF3 axis) RNA Pull-Down//Western Blot//FISH//qRT-PCR//Luciferase Report Assay circNfix was downregulated in Ang II-treated cardiomyocytes. Similarly, circNfix expression was markedly downregulated in mice following TAC surgery. Luciferase activity and RNA pull-down assays indicated that circNfix could indirectly target activating transcription factor 3 (ATF3) by binding with microRNA (miR)-145-5p in cardiomyocytes. miR-145-5p overexpression or ATF3 knockdown could reverse the effects of circNfix in Ang II-treated mouse cardiomyocytes. Yes In addition, circNfix overexpression significantly prevented the progression of cardiac hypertrophy in TAC-treated mice. 34468254 UNC5B-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,CRC cells regulation[mTOR pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay The qRT-PCR results indicated that the UASR1 expression was up-regulated in 39/45 CRC tissues, and it identically presented the up-regulated expression level in the CRC cells. The highly expressed UASR1 facilitates the malignant proliferation of CRC via the mTOR signaling pathway. Yes After the UASR1 expression was interfered, the CRC cell proliferation ability was degraded according to the CCK-8 assay and colony formation assay. 32271416 UNC5B-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC cells interaction[H3K27me,NDRG2 ,EZH2] CCK8//qRT-PCR//Colony Formation Assay//Western Blot RT-qPCR assay confirmed the upregulation of UNC5B-AS1 in OC cells. Together, we first illustrated that UNC5B-AS1 promoted OC progression by regulating the H3K27me on NDRG2 via EZH2, indicating UNC5B-AS1 as a potential molecular target for OC treatment. Yes Functionally, depletion of UCN5B-AS1 hindered proliferation and prompted apoptosis in OC cells. 31903696 UNC5B-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Interaction(miR-375/JAK2 axis) qRT-PCR//Western Blot The results demonstrated that UASR1 was upregulated in OSCC tissues compared with non-tumor tissues, and the high level of UASR1 expression was associated with poor overall survival.Therefore, UASR1 is overexpressed in OSCC and regulates cancer cell proliferation by regulating the miR-375/JAK2 axis. The results demonstrated that UASR1 was upregulated in OSCC tissues compared with non-tumor tissues, and the high level of UASR1 expression was associated with poor overall survival. Yes UASR1 is predicted to interact with miR-375 and the interaction was confirmed by Dual-luciferase activity assay. However, overexpression of UASR1 and miR-375 did not affect the expression of each other. Instead, upregulation of JAK2, a target of miR-375, was observed after the overexpression of UASR1 in OSCC cells. Moreover, overexpression of UASR1 attenuated the inhibitory effects of miR-375 on the expression of JAK2 and cell proliferation. 33732364 UNC5B-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(miR-4455/RSPO4 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay UNC5B-AS1 is up-regulated in CC tissues and cells. Mechanistically, UNC5B-AS1 binds with miR-4455 to up-regulate RSPO4 expression. RSPO4 is targeted by miR-4455 and its expression is negatively regulated by miR-4455 expression. Yes The knockdown of UNC5B-AS1 inhibits CC cell proliferation, migration and invasion and promotes CC cell apoptosis. In vivo assays revealed that UNC5B-AS1 depletion or miR-4455 overexpression inhibits tumor growth by regulating RSPO4 expression. 34350661 UNC5B-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary thyroid tissue Expression[highly expressed] qRT-PCR These results suggested that the lncRNA UNC5B-AS1 was significantly upregulated in both the TCGA cohort and our tissue cohort. Upregulated UNC5B-AS1 correlated with lymph node metastasis (P < 0.001), tumor size (P = 0.002) and histological type (P = 0.013). Yes Downregulating UNC5B-AS1 expression at the RNA level significantly inhibited cell proliferation, colony formation, migration, and invasion in PTC cell lines (TPC1 and BCPAP). 30805847 circWHSC1 CircRNA Mus musculus Uterine Cervical Neoplasms CaCx tissues and cell lines Interaction(miR-532-3p/LTBP2 axis) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//Wound Healing Assay//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//H&E Staining//Colony Formation Assay//Transwell Assay CircWHSC1 was overexpressed in CaCx tissues and cell lines and its high expression was inversely associated with the survival rate of patients with CaCx. CircWHSC1 silencing was capable of suppressing the proliferation, metastasis, and invasion of tumor cells and inducing apoptosis. Investigation to its molecular mechanism revealed that circWHSC1 functioned as a competitive endogenous RNA (ceRNA), mediating LTBP2 expression by targeting miR-532-3p. The in vivo experiments further confirmed the inhibition of tumor growth and metastasis by circWHSC1 knockdown. The circWHSC1-mediated miR-532-3p/LTBP2 signaling axis might be a novel therapeutic target for CaCx. Yes CircWHSC1 silencing was capable of suppressing the proliferation, metastasis, and invasion of tumor cells and inducing apoptosis. Investigation to its molecular mechanism revealed that circWHSC1 functioned as a competitive endogenous RNA (ceRNA), mediating LTBP2 expression by targeting miR-532-3p. The in vivo experiments further confirmed the inhibition of tumor growth and metastasis by circWHSC1 knockdown. 35235125 hsa_circ_0008068 CircRNA Mus musculus Squamous Cell Carcinoma of Head and Neck Interaction(microRNA-153-3p/acylgycerol kinase (AGK) axis) qRT-PCR//RIP//Western Blot we found that the appearance of circ_0008068 and AGK was increased, and miR-153-3p content was diminished in OSCC. Circ_0008068 lack subdued cell proliferation, migration, invasion, tube formation and glycolysis metabolism, but stimulated cell apoptosis in OSCC. In addition, circ_0008068 bound to miR-153-3p to modulate the expression of its target AGK. Besides, miR-153-3p was validated to act as a tumor suppressor in OSCC tumorigenesis by suppressing AGK. Additionally, circ_0008068 knockdown also attenuated tumor growth in nude mice. In all, circ_0008068 expedited the growth of OSCC by miR-153-3p/AGK axis. Yes Additionally, circ_0008068 knockdown also attenuated tumor growth in nude mice. 35635053 circPank1 CircRNA Mus musculus Parkinson Disease PD model mice and MN9D cell model Interaction( miR-7a-5p/α-syn signaling axis) qRT-PCR//Luciferase Report Assay Circ-Pank1 is highly expressed in the substantia nigra (SN) of PD model mice treated with rotenone and in the MN9D cell model of dopaminergic neurons. We found that circ-Pank1 could adsorb miR-7a-5p and upregulate the expression of α-synuclein (α-syn), which is a molecular hallmark closely related to PD. The inhibition of miR-7a-5p reversed the circ-Pank1 knockdown-induced amelioration of dopaminergic neuron injury. Yes . The circ-Pank1 knockdown ameliorated dopaminergic neuron damage and locomotor dysfunction after the treatment with rotenone. 35589691 circSAMD4A CircRNA Mus musculus Parkinson Disease PD animal and cellular models Interaction(miR‑29c‑3p/AMPK/mTOR) qRT-PCR//Tunel//Western Blot It was found that circSAMD4A was upregulated, while miR‑29c‑3p was downregulated in both PD animal and cellular models. Moreover, circSAMD4A directly targeted and negatively regulated miR‑29c‑3p.Collectively, these results suggested that circSAMD4A participated in the apoptosis and autophagy of dopaminergic neurons by modulating the AMPK/mTOR cascade via miR‑29c‑3p in PD. Yes Further studies identified that circSAMD4A knockdown inhibited MPTP? or MPP+?induced apoptosis and autophagy; however, these effects were abolished by an miR?29c?3p inhibitor. 34080649 circDLGAP4 CircRNA Mus musculus Parkinson Disease ventral midbrains Interaction[miR-134-5p/CREB pathway] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot First, we detected the expression of circDLGAP4 in PD models using qRT-PCR and the results showed that circDLGAP4 expression was decreased in both MPTP-induced PD mouse model and MPP-induced PD cell models (Fig. 1A–C). Functional investigations declared that miR-134-5p inhibitors could attenuated the biological effect of circDLGAP4 siRNAs and miR-134-5p mimics could reverse the biological effect of circDLGAP4 overexpression Yes We found that circDLGAP4 knockExpression[down-expression] (Fig. 1D–E) and MPP could inhibit viability (Fig. 1F–G), promote apoptosis (Fig. 1H–K), induce mitochondrial damage and decrease autophagy (Fig. 1L–M) in SH-SY5Y and MN9D cells. And overexpression of circDLGAP4 (Fig. 1D–E) attenuated the effect of MPP in SH-SY5Y and MN9D cells (Fig. 1F–M). 31761328 hsa_circ_0046264 CircRNA Mus musculus Osteosarcoma 58 osteosarcoma tissues and 4 osteosarcoma cell lines Interaction(miR-940 / SFRP1 axis) qRT-PCR//Transwell Assay Here, we demonstrated that circ_0046264 was greatly down-regulated in osteosarcoma and was inversely related to tumor size and Ki67 expression. Mechanistically, circ_0046264 could adsorb miR-940 and indirectly modulate SFRP1 expression. Taken together, circ_0046264 is a tumor suppressor to inhibit the osteosarcoma progression via modulating the miR-940 / SFRP1 axis. Yes Functional assays validated that circ_0046264 could restrain the proliferation, migration and invasion. 34305100 UFC1 LncRNA Homo sapiens Stomach Neoplasms Regulation[miR-498/Lin28b] qRT-PCR UFC1 has a promoting role in GC progression, at least in part, by acting as a miR-498 sponge and derepressing Lin28b expression, which would provide a novel biomarker for GC diagnosis and prognosis and offer a potential target for GC therapy. UFC1 was elevated and predicted poorer prognosis in GC. Yes UFC1 knockdown inhibited while UFC1 overexpression promoted GC cell proliferation, migration, and invasion. 29970131 UFC1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell line Interaction[UFC1/miR-34a] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In present study, we found that UFC1 was highly expressed in breast tissue and cells lines compared with normal tissues and cell lines. Furthermore, over-expressing miR-34a could prominently suppress cell growth, invasion, migration and inducing apoptosis in breast cancer cells. In addition, we verified that miR-34a was a target of CXCL10 by bioinformatics analysis and luciferase reporter assay. CONCLUSIONS LncRNA UFC1 regulated biological activity of breast cancer via miR-34a/CXCL10 axis, providing a novel diagnosis biomarker and potential therapeutic target for breast cancer. Yes Silenced UFC1 suppressed multiple biological activities of breast cancer cells, which also functioned as a miR-34a sponge in breast cancer. 31544897 UFC1 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Regulation[GSK-3β/β-catenin axis] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay The results of Western blotting showed that the expressions of proteins associated with the cell invasion and migration, namely β-catenin and P-GSK-3β, were significantly upregulated in response to lincRNA-UFC1 overexpression, and were obviously lowered after lincRNA-UFC1 knockdown. Treatment of the cells with XAV-939 significantly reversed the effect of lincRNA-UFC1 overexpression on the cell invasion and migration (P < 0.001). Yes Overexpression of lincRNA-UFC1 significantly promoted the invasion and migration of Huh7 cells as compared with the control cells (P < 0.001), while lincRNA-UFC1 knockdown obviously suppressed the invasion and migration of BEL-7402 cells (P < 0.001). 31270046 UFC1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Regulation[E2F1-linc-UFC1/miR-34a/FOXP3 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay Here, it was demonstrated that linc-UFC1 expression was significantly increased in cervical cancer tissues, and its overexpression was associated with the poor survival of patients with cervical cancer. Taken together, our findings indicate that the linc-UFC1 expression signature may serve as a novel biomarker for the diagnosis and prognosis of cervical cancer, and it is also highlighted that the E2F1-linc-UFC1/miR-34a/FOXP3 axis may be a potentially therapeutic target of cervical cancer. Here, it was demonstrated that linc-UFC1 expression was significantly increased in cervical cancer tissues, and its overexpression was associated with the poor survival of patients with cervical cancer. Yes Loss-of-function assays indicated that linc-UFC1 exerted as an oncogene because it promoted the growth and metastasis of cervical cancer cells in vitro and in vivo. 29790665 hsa_circ_0008870 CircRNA Homo sapiens Idiopathic Short Stature chondrocytes, ISS children Interaction(miR-185-3p/ MAPK1 axis) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay The authors first confirmed that hsa_ circ_0008870 was downregulated in ISS children. Mechanistically, hsa_circ_0008870 regulates MAPK1 expression by sponge miR-185-3p. This mechanism of action was further verified through rescue experiments. Finally, the authors revealed that the silencing of hsa_circ_0008870 induces low expression of MAPK1 by impairing the sponge action of miR-185-3p, thereby inhibiting chondrocyte proliferation, hypertrophy, and endochondral ossification, which results in a short stature phenotype. In addition to these, we also observed an interesting phenomenon that upregulated of miR-185-3p can in turn inhibit the expression of hsa_circ_0008870 in chondrocytes. Yes Meanwhile, we also observed that the downregulated hsa_circ _0008870 significantly inhibited chondrocyte proliferation and endochondral ossification in vivo and in vitro. 36304901 hsa_circ_0063476 CircRNA Homo sapiens Idiopathic Short Stature ISS exosome Interaction(miR-518c-3p/DDX6 Axis) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Microarray//Cell Proliferation Assay//Cell Cycle Assay//Bioinformatics Analysis Subsequently, upregulation of hsa_circ_0063476 in ISS exosome was identified. Our study further revealed hsa_circ_0063476 overexpression in vitro can enhance chondrocyte apoptosis and inhibit the expression of markers of chondrocyte proliferation and endochondral ossification via miR-518c-3p/DDX6 axis. Yes In vitro experiments demonstrated that chondrocyte proliferation, cell cycle and endochondral ossification were suppressed, and apoptosis was increased following hsa_circ_0063476 overexpression in human chondrocytes. Conversely, silencing hsa_circ_0063476 in human chondrocytes can show opposite outcomes. 35974445 TTN-AS1 LncRNA Homo sapiens Breast Neoplasms TNBC tissues and cell lines Interaction(miR‑211‑5p) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The results demonstrated that TTN‑AS1 expression was significantly upregulated, whereas that of miR‑211‑5p was found to be downregulated in TNBC tissues and cell lines compared with the matched adjacent normal tissues and normal breast epithelial cell line MCF‑10A, respectively. The results from luciferase reporter assay confirmed that miR‑211‑5p was a direct target of TTN‑AS1, suggesting that TTN‑AS1 may bind directly to miR‑211‑5p to negatively regulate its expression. Yes Furthermore, TTN?AS1?knockdown inhibited the proliferation and invasive and migratory abilities of MDA?MB?453 and MDA?MB?231 cells, which was reversed following co?transfection with the miR?211?5p inhibitor. 33179096 hsa_circ_0026344 CircRNA Homo sapiens Emphysema alveolar epithelial cells Interaction(miR-21/PTEN/ERK axis) In Vivo Experiment Further, in alveolar epithelial cells, overexpression of circRNA_0026344 blocked cigarette smoke extract (CSE)-induced autophagy and apoptosis, but this blockage was reversed by upregulation of miR-21 with a mimic. These results demonstrated that, in alveolar epithelial cells, CS decreases circRNA_0026344 levels, which sponge miR-21 to inhibit the miR-21 target, PTEN, which, in turn, activates ERK and thereby promotes autophagy and apoptosis, leading to emphysema. Thus, for emphysema, circRNA_0026344 regulates the PTEN/ERK axis by sponging miR-21, which is associated with the CS-induced autophagy and apoptosis of alveolar epithelial cells. Yes Further, in alveolar epithelial cells, overexpression of circRNA_0026344 blocked cigarette smoke extract (CSE)-induced autophagy and apoptosis, but this blockage was reversed by upregulation of miR-21 with a mimic. These results demonstrated that, in alveolar epithelial cells, CS decreases circRNA_0026344 levels, which sponge miR-21 to inhibit the miR-21 target, PTEN, which, in turn, activates ERK and thereby promotes autophagy and apoptosis, leading to emphysema. 34524572 TUG1 LncRNA Homo sapiens Retinoblastoma RB cell lines Regulation(Notch signaling ) Western Blot//Wound Healing Assay//qRT-PCR//IF//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay RB cell lines similarly exhibited marked TUG1 upregulation.Subsequent quantitative real-time polymerase chain reaction (qPCR) and Western blotting indicated that this lncRNA functions at least in part by influencing the expression of Notch signaling pathway genes, which were downregulated following TUG1 knockdown in RB cells. Yes In these assays, TUG1 upregulation was found to promote RB cell proliferative, migratory, and invasive activity while inducing the epithelial-mesenchymal transition (EMT). 35176897 TUG1 LncRNA Homo sapiens Melanoma melanoma tissues Interaction[miR‑29c‑3p, RGS1] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Moreover, the expression of TUG1 was upregulated in metastatic melanoma compared with primary melanoma tissues.Taken together, the data of the present study demonstrated that TUG1 promoted proliferation and invasion and suppressed apoptosis in melanoma cells by regulating miR‑29c‑3p and its target gene, RGS1. The aim of the present study was to investigate whether TUG1 expression is relatively higher in melanoma tissues and whether this expression is correlated with poor overall survival. Yes Knockdown of TUG1 was found to suppress melanoma cell growth and metastasis and induce cell apoptosis. By contrast, the overexpression of TUG1 promoted the growth and metastasis of melanoma cells, and inhibited their apoptosis. 30720136 TUG1 LncRNA Homo sapiens Melanoma melanoma tumor tissues and cell lines Interaction(TUG1/miR-145-5p/SOX2 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//Transwell Assay TUG1 expression levels were elevated in melanoma tumor tissues and cell lines.The expression levels of miR-145-5p were decreased in melanoma tumor tissues and cell lines. TUG1 directly targeted miR-145-5p and downregulated miR-145-5p. Upregulation of TUG1 counteracted the promotion of the proliferative, migratory and invasive abilities of melanoma cells induced by the overexpression of miR-145-5p. SOX2 was a target of miR-145-5p and its expression was negatively regulated by miR-145-5p, while positively regulated by TUG1. TUG1 regulated SOX2 expression through sponging miR-145-5p. Yes Reduced TUG1 expression levels significantly inhibited the proliferative, migratory and invasive abilities of melanoma cells. Silencing of TUG1 also inhibited melanoma tumorigenesis in mice. 35949341 circNPHP4 CircRNA Homo sapiens Coronary Artery Disease sEVs from CAD-related monocytes Interaction(miR-1231) Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//ChIP In this study, we investigated global changes in the expression patterns of circRNAs in sEVs from CAD-related monocytes and identified circNPHP4 as a significantly upregulated circRNA. Investigations of the underlying mechanisms revealed that circNPHP4 contains a functional miR-1231-binding site. Yes Knockdown of circNPHP4 inhibited heterogeneous adhesion between monocytes and coronary artery endothelial cells and reduced ICAM-1 and VCAM-1 expression. 34650036 TUG1 LncRNA Homo sapiens Myocardial Infarction blood Expression[highly expressed] qRT-PCR The expression levels of lncRNA TUG1 were significantly increased in MI patients. And low lncRNA TUG1 expression group had a significantly higher overall survival rate than that of high lncRNA TUG1 expression group. Yes Overexpression of lncRNA TUG1 promoted the apoptosis of AC16 cells and upregulated the expression of cleaved caspase- 3. 32767580 TUG1 LncRNA Homo sapiens Myocardial Infarction cardiac myofibroblast Interaction(miR-133b/CTGF axis ) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay The expression level of TUG1 increased following AngII treatment in cardiac myofibroblast. Collectively, our study suggested that TUG1 mediates CTGF expression by sponging miR-133b in the activation of cardiac myofibroblasts. The current work reveals a unique role of the TUG1/miR-133b/CTGF axis in MF, thus suggesting its immense therapeutic potential in the treatment of cardiac diseases. Yes TUG1 knockdown inhibited the Ang-II induced cardiac myofibroblast activation and TUG1 overexpression increased proliferation and collagen generation of cardiac myofibroblasts. 34553456 TUG1 LncRNA Homo sapiens Myocardial Infarction cardiomyocytes Interaction(HIF-1α/TUG1/FUS ) In Vivo Experiment//Western Blot//Tunel//CCK8//RIP//Flow Cytometry//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC//ChIP Mitochondrial dysfunction and pyroptosis were induced in H/R-treated cardiomyocytes, accompanied by an increase in the expression of HIF-α and TUG1. HIF-1α promoted TUG1 expression by directly binding to the TUG1 promoter. HIF-1α targeting upregulated TUG1 promotes mitochondrial damage and cardiomyocyte pyroptosis by combining with FUS, thereby promoting the occurrence of MI. HIF-1α/TUG1/FUS may serve as a potential treatment target for MI. Yes TUG1 silencing inhibited H/R-induced ROS production, mitochondrial injury and the expression of the pyroptosis-related proteins NLRP3, caspase-1 and GSDMD. Additionally, H/R elevated FUS levels in cardiomyocytes, which were directly inhibited by TUG1 silencing. Fused in sarcoma (FUS) overexpression reversed the effect of TUG1 silencing on mitochondrial damage and caspase-1 activation. However, the ROS inhibitor N-acetylcysteine (NAC) promoted the protective effect of TUG1 knockdown on H/R-induced cardiomyocyte damage. The in vivo MI model showed increased infarction, myocardial injury, ROS levels and pyroptosis, which were inhibited by TUG1 silencing. 35396503 circOSBPL2 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive lung tissues of smokers without or with COPD Interaction(miR-193a-5p/BRD4 Axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//ELISA Circ-OSBPL2 was highly expressed in lung tissues of smokers without or with COPD, particularly in smokers with COPD. Mechanistically, circ-OSBPL2 served as a sponge for miR-193a-5p, and miR-193a-5p inhibition reversed the effects of circ-OSBPL2 knockdown on CSE-mediated HBECs. Besides that, miR-193a-5p directly targeted BRD4, and miR-193a-5p re-expression in HBECs abolished CSE-induced HBEC injury, which was reverted by BRD4 up-regulation. Additionally, we also found circ-OSBPL2 could indirectly regulate BRD4 via miR-193a-5p. Yes Circ-OSBPL2 down-regulation in HBECs attenuated CSE-evoked cell proliferation arrest, and cell apoptosis, inflammation and oxidative stress promotion. 33854310 circNCKAP1 CircRNA Homo sapiens Wilms Tumor skin BCC tissues Interaction(miR-148b-5p/HSP90 axis) Transfection//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Bioinformatics Analysis Circ_NCKAP1 was found to be significantly upregulated in skin BCC tissues (p<0.05). Moreover, Dual-Luciferase reporter assay identified that circ_NCKAP1 could bind to miR-148b-5p directly, and HSP90 was targeted by miR-148b-5p. Yes loss-of-function assays demonstrated that circ_NCKAP1 knockdown markedly inhibited cell proliferation and promoted cell apoptosis (p<0.05). 34533810 hsa_circ_0007059 CircRNA Homo sapiens Nephritis type I interferon (IFN)-treated renal mesangial cells (RMCs), lupus nephritis (LN) specimens, and HEK293 cells Interaction(microRNA-1278/SHP-1/STAT3 signaling) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//MTT//Luciferase Report Assay//Microarray In the present study, the expression of circ_0007059 in type I interferon (IFN)-treated renal mesangial cells (RMCs), lupus nephritis (LN) specimens, and HEK293 cells was downregulated compared with that in normal healthy samples and untreated cells. Further, the increased expression resulted in reduced inflammation and the downregulation of CXCL10, IFIT1, ISG15, and MX1 in RMCs and HEK293 cells. Circ_0007059 serves as a sponge for miR-1278 so that the latter can target the 3'-untranslated region of SHP-1. Yes Circ_0007059 overexpression resulted in increased cell proliferation, cell viability, apoptosis, and inflammation-associated factors (CXCL10, IFIT1, ISG15, and MX1) in RMCs and HEK293 cells. In addition, circ_0007059 overexpression significantly restored cell proliferation and viability and inhibited IFN-induced apoptosis. 34535085 TUG1 LncRNA Homo sapiens Cerebral Ischemia/Reperfusion Injury OGD/R model of MA-C cells Interaction(miR-142-3p) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay TUG1 was upregulated, while miR-142-3p was downregulated in the OGD/R model of MA-C cells.Inhibition of OGD/R-induced increases in TUG1 expression that in turn reduces miR-142-3p upregulation may suppress reperfusion-induced losses in cell Yes Inhibiting the expression of TUG1 could protect MA-C cells and reverse the decrease in growth viability and increasing apoptosis of MA-C cells caused by OGD/R stimulation. On the other hand, the inhibition of miR-142-3p offset the effect of TUG1 knockdown on cell viability and apoptosis. 34153134 TUG1 LncRNA Homo sapiens capillary hemangioma infant hemangioma tissues Interaction(miR-137/IGFBP5 axis) In Vivo Experiment//IHC//Western Blot//ISH//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//IF TUG1 was significantly upregulated in infant hemangioma tissues compared with normal adjacent subcutaneous tissues. Specifically, TUG1 could compete with IGFBP5 for miR137 binding. Rescue experiments further confirmed the role of the TUG1/miR137/IGFBP5 axis in HemECs. Yes The loss- and gain-of-function approaches indicated that TUG1 overexpression promoted proliferation, migration, and invasion of HemECs in vitro, and TUG1 knockdown inhibited the tumorigenesis of HemECs in vivo. 34362467 circADARB1 CircRNA Homo sapiens Lymphoma, T-Cell NKTCL patients Interaction(miR-214-3p / p-Stat3. ) In Vivo Experiment//Western Blot//Tunel//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Microarray//Cell Proliferation Assay//IHC//Bioinformatics Analysis The relative expressions of circADARB1 were significantly higher in NKTCL patients. CircADARB1 could bind to miR-214-3p in the downstream and regulate the expression of p-Stat3. Yes The knockdown of circADARB1 inhibited proliferation of NKTCL cells in vitro and in vivo. In nude mice tumor tissue, p-Stat3 was under-expressed in the circADARB1 knockdown group. 34736477 TUG1 LncRNA Homo sapiens Arthritis, Rheumatoid synovial fibroblast-like synoviocytes Interaction( miR-34a-5p/LDHA) RNA Pull-Down//Transfection//qRT-PCR//Luciferase Report Assay//Transwell Assay TUG1 expression was significantly upregulated in synovial fibroblast-like synoviocytes (FLSs) compared with normal FLSs. Bioinformatics analysis indicated that TUG1 interacted with miR-34a-5p. RNA pull-down assay and luciferase assay validated that TUG1 sponged miR-34a-5p in FLSs-RA. Overexpression of miR-34a-5p effectively inhibited glucose metabolism of FLSs-RA. Furthermore, the glucose metabolism of FLSs-RA was significantly elevated compared with normal FLSs. The glucose metabolism enzyme, LDHA, was directly targeted by miR-34a-5p in FLSs. Finally, we showed restoration of miR-34a-5p in TUG1-overexpressing FLSs-RA successfully overcame the TUG1-promoted glucose metabolism and apoptosis resistance via targeting LDHA. Yes . Functional assays uncovered that silence of TUG1 suppressed FLSs-RA invasion, migration, glucose metabolism, and increased apoptosis. 34403518 TUG1 LncRNA Homo sapiens Pulmonary Disease, Chronic Obstructive lung tissues Regulation[ miR-145-5p/DUSP6 axis ] qRT-PCR//IF//Luciferase Report Assay//Western Blot We found that the expression of TUG1 was significantly higher in the sputum cells and lung tissues of patients with COPD as compared to that in non-smokers, and negatively correlated with the percentage of predicted forced expiratory volume in 1 second.Moreover, TUG1 expression was higher in CS extract (CSE)-treated human bronchial epithelial cells and lung fibroblasts, whereas inhibition of TUG1 reversed CSE-induced inflammation and collagen deposition in vitro. Mechanistically, TUG1 promoted the expression of dual-specificity phosphatase 6 (DUSP6) by sponging miR-145-5p. DUSP6 overexpression reversed TUG1 knockdown-mediated inhibition of inflammation and airway remodelling. These findings suggested an important role of TUG1 in the pathological alterations associated with CS-mediated airway remodelling in COPD. Thus, TUG1 may be a promising therapeutic target in CS-induced airway inflammation and fibroblast activation. Yes In addition, up-regulation of TUG1 was observed in CS-exposed mice, and knockdown of TUG1 attenuated inflammation and airway remodelling in a mouse model. 31557398 TUG1 LncRNA Homo sapiens Pulmonary Disease, Chronic Obstructive HPMECs Interaction(miR-9a-5p/BCL2L11 axis) qRT-PCR//Transfection//Luciferase Report Assay//Western Blot The results showed that CSE induced cell apoptosis and increased lncRNA TUG1 expression in HPMECs. CSE significantly reduced the expression of miR-9a-5p in HPMECs compared with the control group. Yes TUG1-short hairpin RNA relieved cell apoptosis induced by CSE by upregulating miR-9a-5p in HPMECs. 34257718 circMKLN1 CircRNA Homo sapiens Retinoblastoma RB tissues and cells Interaction(miR-425-5p/PDCD4 Axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircMKLN1 was downregulated in RB tissues and cells. Furthermore, as the target gene of miR-425-5p, PDCD4 silencing could ameliorate the suppressive roles of circMKLN1 in RB cell growth and metastasis. High levels of circMKLN1 were related to a favorable outcome of RB patients. Yes CircMKLN1 was resistant to RNase R digestion and circMKLN1 overexpression repressed RB cell proliferation, migration and invasion in vitro. MiR-425-5p was identified as the target of circMKLN1 and miR-425-5p elevation reversed the effects of circMKLN1 overexpression on RB cell malignant behaviors. 33988065 TUG1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cells regulation[MiR-31-5p/FLOT1 Axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP TUG1 was dramatically up-regulated in ccRCC tissues and cells.All data demonstrated that TUG1 promotes cell proliferation and inhibits cell apoptosis and autophagy in ccRCC by miR-31-5p/FLOT1 axis, which may provide a therapeutic target for ccRCC patients. Yes TUG1 silencing inhibited cell proliferation and promoted cell apoptosis, autophagy in 786-0 and A498 cells. In addition, TUG1 depletion repressed tumor growth in vivo. 32606796 TUG1 LncRNA Homo sapiens Prostatic Neoplasms PCa cells regulation[Nrf2 signaling axis] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay TUG1 was strikingly upregulated in PCa cells compared with non-tumorigenic human prostate epithelial cells. LncRNA TUG1 plays an oncogenic role in human PCa cells by promoting the cell proliferation and invasion in PCa cell lines, at least partly via the Nrf2 signaling pathway. Yes Subsequently, inhibition of TUG1 using siRNA resulted in deceased proliferation, migration, and invasion of PCa cells; however, these effects were reversed by treatment with oltipraz (an activator of Nrf2). 32057513 TUG1 LncRNA Homo sapiens Parkinson Disease blood Expression[highly expressed] CCK8//qRT-PCR TUG1 was highly expressed in the serum of PD patients. Yes Besides, animal experiments suggested that the downregulation of TUG1 significantly improved the motor coordination ability of the PD mice and inhibited the expression of inflammatory factors. 33085068 TUG1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues,cell line Interaction[PUM2] qRT-PCR TUG1 was Expression[Expression[up-expression]-expression]regulated in CC, especially in those with worse TNM staging and larger tumor size. The overexpression of TUG1 enhanced proliferative and migratory abilities of Hela and SiHa cells. TUG1 was mainly distributed in the cytoplasm. PUM2 interacted with TUG1 and its level was positively regulated by TUG1. Yes The silence of PUM2 reversed the promotive effect of TUG1 on the viability of the CC cells. 31646551 TUG1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(micro RNA-377-3p) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expressions of lncRNA TUG1 and Ezrin were upregulated in OS tissues and cells determined by quantitative reverse transcription-PCR (qRT-PCR) and Western blot (WB), respectively. Moreover, lncRNA TUG1 upregulated Ezrin expression through sponging miR-377-3p determined by dual-luciferase reporter gene assay and WB. Yes In addition, both lncRNA TUG1 and Ezrin promoted OS cell proliferation identified by Cell Counting Kit-8 (CCK-8) assay and clone formation assay, and enhanced OS cell invasion detected using Transwell assay for cell invasion. 35012433 TUG1 LncRNA Homo sapiens Osteosarcoma OS tissues, OS cell lines, and primary OS cells Interaction(miR-132-3p/SOX4 axis) qRT-PCR//Western Blot TUG1 was highly expressed in human OS tissues, OS cell lines, and primary OS cells. TUG1 facilitated proliferation and suppressed apoptosis by regulating the miR-132-3p/SOX4 axis in human OS cell lines and primary OS cells. Yes TUG1 knockdown hindered proliferation and induced apoptosis in human OS cell lines and primary OS cells. 29436190 TUG1 LncRNA Homo sapiens Leukemia, Myeloid, Acute Bone marrow samples Expression[highly expressed] CCK8//qRT-PCR//Western Blot LncRNA TUG1 expression was higher in AML patients compared to controls, and it was positively correlated with white blood cell counts as well as poor risk stratification. Yes In the in vitro experiments, lncRNA TUG1 expression was upregulated in AML cell lines compared to control cells, and cell proliferation ability was reduced, but cell apoptosis rate was promoted in TUG1 (-) group compared to NC (-) group at 72 hours after transfection in KG-1 cells. 30452403 circARF3 CircRNA Homo sapiens Subarachnoid Hemorrhage plasma and CSF in SAH patients Interaction(miR-31-5p/MyD88/NF-κB axis) Western Blot//Transfection//Tunel//qRT-PCR//Luciferase Report Assay//ELISA//IHC//IF circARF3 was significantly down-regulated in plasma and CSF in SAH patients with higher Fisher stages. Mechanistically, circARF3 sponged miR-31-5p as an endogenous competitive RNA and dampens its expression, thus inactivating MyD88-NF-κB pathway. CircARF3 attenuates BBB destruction in SAH rats by regulating the miR-31-5p-activated MyD88-NF-κB pathway. Yes In the SAH rat model, overexpressing circARF3 improved BBB integrity and neurological score, decreased neuronal apoptosis and microglial activation in ipsilateral basal cortex, with declined miR-31-5p expression and MyD88-NF-κB activation. In vitro, overexpressing circARF3 attenuated OGD-mediated integrity destruction of BMECs and microglial induced neuroinflammation, while overexpressing miR-31-5p had opposite effects. 34511434 hsa_circ_0003420 CircRNA Homo sapiens Leukemia, Myeloid non-m3 AML stem cells Interaction(IGF2BP1) Western Blot//Transfection//qPCR//CCK8//EdU Staining Compared with normal hematopoietic stem cells, circular RNA hsa-circ_0003420 expression was considerably decreased in non-m3 AML stem cells. Overexpression of hsa-circ_0003420 via transfection caused LSC death and inhibited the characteristics of leukemia tumor stem cells, including expression of Homeobox B4 (HOXB4), MYB, and aldehyde dehydrogenase 1 family member A1 (ALDH1A1) axis. Furthermore, hsa-circ_0003420 targets the mRNA of insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and hsa-circ_0003420 expression markedly repressed IGF2BP1 levels in LSCs. Furthermore, the lack of hsa-circ_0003420 is correlated with poor clinical results and impaired therapeutic effects in AML. Yes Overexpression of hsa-circ_0003420 via transfection caused LSC death and inhibited the characteristics of leukemia tumor stem cells, including expression of Homeobox B4 (HOXB4), MYB, and aldehyde dehydrogenase 1 family member A1 (ALDH1A1) axis. 34477035 TUG1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML specimens and cells (HL-60, KG-1, MOLM-14, and MOLM-13) interaction[targeting miR-185] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay TUG1 was upregulated and miR-185 was downregulated in the peripheral blood mononuclear cells of AML specimens and cells (HL-60, KG-1, MOLM-14, and MOLM-13). Expression of TUG1 was upregulated in AML patients and cells, and its knockdown repressed cell proliferation and glycolysis in AML cells in vitro by targeting miR-185. Yes Both TUG1 knockdown and miR-185 overexpression via transfection could suppress cell viability, glucose consumption, lactate production, and hexokinase 2 expression, but promote apoptotic rate in HL-60 and KG-1 cells. 32982274 TUG1 LncRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues and cells regulation[miR-1294/ PLK1 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay TUG1 was overexpressed in esophageal cancer tissues and cells. TUG1 was found as oncogenic gene in esophageal cancer. Mechanically, TUG1 attributed to esophageal cancer process by regulating miR-1294/ PLK1 axis. Yes TUG1 was found as oncogenic gene in esophageal cancer. Mechanically, TUG1 attributed to esophageal cancer process by regulating miR-1294/ PLK1 axis. 33009634 circORC2 CircRNA Homo sapiens Constipation STC group Interaction(miR-19a) qRT-PCR//Luciferase Report Assay//Western Blot Also, miR-19a level was highest, whereas circORC2 level was lowest in the STC group. Furthermore, circORC2 was validated to sponge the expression of miR-19a, and the transfection of circORC2 reduced the expression of miR-19a. Meanwhile, MLN and NST mRNAs were both targeted by miR-19a, and the transfection of circORC2 dramatically up-regulated the expression of MLN and NST. Yes Collectively, the results of this study established a regulatory relationship among circORC2, miR-19a and neurotensin/motilin, which indicated that the overexpression of circORC2 could up-regulate the levels of neurotensin and motilin, thus exerting a beneficial effect during the treatment of STC. 33629528 circKL CircRNA Homo sapiens Kidney Neoplasms kidney cancer cells and tissues Interaction(miR‑182‑5p/FBXW7) In Vivo Experiment//IHC//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this analysis, a novel circRNA (hsa_circ_0100312, named circKL) was identified as a frequently downregulated circRNA in kidney cancer cells and tissues by reverse transcription‑quantitative PCR. All results suggested that circKL suppressed the growth and migration of kidney cancer by sponging microRNA (miR)‑182‑5p and upregulating FBXW7 expression. Overall, the circKL/miR‑182‑5p/FBXW7 axis was indicated to have a key role in the growth and metastasis of kidney cancer and may be targeted as a novel therapeutic strategy. Yes The experiments confirmed that circKL overexpression significantly inhibited the proliferation, migration, tumor growth and metastasis of kidney cancer both in vitro and in vivo. 35179220 TUG1 LncRNA Homo sapiens Prostatic Neoplasms PC tissues and cells (DU145 and PC3) regulation[microRNA-496/Wnt/β-catenin pathway] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay TUG1 was highly expressed in PC tissues and cells (DU145 and PC3). TUG1 knockdown suppressed PC cell proliferation, migration and invasion in vitro and curbed PC xenograft growth in vivo by regulating miR-496/Wnt/ β-catenin signaling pathway, deepening our understanding on etiology of PC. Yes TUG1 knockdown inhibited proliferation, migration and invasion in DU145 and PC3 cells. 32427740 TUG1 LncRNA Homo sapiens Glioma cells Regulation qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Invasion Assay The apoptotic rate of cells in the TUG1-knockdown group was significantly higher than in the negative control (NC) group (11.58 vs. 9.14%, P<0.01). CCK-8 assay data demonstrated that the proliferative ability of cells within the TUG1-knockdown group was lower compared with that of the NC group. A Transwell invasion assay was performed, which revealed that the number of invaded cells from the TUG1-knockdown group was the less compared with that of the NC group. In addition, the G0/G1 phase population was significantly increased within the treated group (44.85 vs. 38.45%, P<0.01), as measured by flow cytometry. The present study demonstrated that the downregulation of TUG1 may inhibit proliferation and invasion, and promote glioma U251 cell apoptosis. Yes The apoptotic rate of cells in the TUG1-knockdown group was significantly higher than in the negative control (NC) group (11.58 vs. 9.14%, P<0.01). CCK-8 assay data demonstrated that the proliferative ability of cells within the TUG1-knockdown group was lower compared with that of the NC group. A Transwell invasion assay was performed, which revealed that the number of invaded cells from the TUG1-knockdown group was the less compared with that of the NC group. In addition, the G0/G1 phase population was significantly increased within the treated group (44.85 vs. 38.45%, P<0.01), as measured by flow cytometry. 29467911 TUG1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and NPC cell lines Interaction[miR-384 ] IHC//Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay In the study, for the first time, we discovered that lnc RNA taurine upregulated gene 1 (TUG1) exhibited higher expression levels in NPC tissues and NPC cell lines than in normal nasopharyngeal epithelial tissues and normal nasopharyngeal cell line. In conclusion, our findings suggested that there was a negative correlation between TUG1 and miR-384 in NPC patients. TUG1 might be an effective candidate for use in NPC diagnosis, prognosis and treatment. In addition, patients with NPCs showing higher levels of TUG1 had worse overall survivals. Yes Further, suppressing TUG1 expression markedly reduced the cell proliferation, migration and invasion; however, TUG1 over-expression significantly enhanced the proliferation, migration and invasion in NPC cells. 30581000 TUG1 LncRNA Homo sapiens Atherosclerosis AS tissues regulation[miR-141-3p/ROR2 Axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expression of TUG1 and ROR2 was promoted in AS tissues and ox-LDL-treated HA-VSMCs. TUG1 enhanced the progression of AS in vitro by regulating the miR-141-3p/ROR2 axis. Yes Silencing of TUG1 inhibited the proliferation, migration, invasion, and metastasis in ox-LDL-treated HA-VSMCs. 32565910 TUG1 LncRNA Homo sapiens Atherosclerosis atherosclerotic serum samples and a cell model Interaction(miR-382-5p) CCK8//qRT-PCR//Transfection//Luciferase Report Assay TUG1 and miR-382-5p expressions were significantly increased and decreased, respectively, in both atherosclerotic serum samples and a cell model. In addition, the expression of TUG1 was negatively correlated with the level of miR-382-5p in atherosclerotic serum samples. Notably, a miR-382-5p inhibitor significantly reversed the effect of TUG1 downregulation on ox-LDL-treated VSMCs, which aggravates the process of atherosclerosis. Yes Moreover, silencing of TUG1 reduced cell growth and enhanced the apoptosis of ox-LDL-treated VSMCs. 34646415 circTNPO3 CircRNA Homo sapiens Stomach Neoplasms 103 pairs of GC tissues Interaction(IGF2BP3/MYC ) In Vivo Experiment//RNA Pull-Down//Northern Blot//Western Blot//ISH//Transfection//qRT-PCR//RIP//migration assay//RNA-seq//Luciferase Report Assay//Cell Proliferation Assay Here, we reported that circ-transportin 3 (TNPO3) was significantly downregulated in 103 pairs of GC tissues compared with matched noncancerous tissues.We further verified that circ-TNPO3 competitively interacted with insulin-like growth factor 2 binding protein 3 (IGF2BP3) protein; thus, the role of IGF2BP3 in stabilizing MYC mRNA was weakened, which inhibited the expression of MYC and its target SNAIL. The level of circ-TNPO3 expression correlated with differentiation of GC, and plasma circ-TNPO3 could serve as a potential diagnostic biomarker. Yes Functionally, circ-TNPO3 inhibited proliferation and migration of GC in vitro and in vivo. 34703650 TUG1 LncRNA Homo sapiens Adenocarcinoma of Lung LAC cells Interaction(miR-138-5p-HIF1A axis) Western Blot//Transfection//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that upregulation of TUG1 or downregulation of miR-138-5p was associated with lymph node or distant metastasis and indicated a poor survival in LAC. TUG1 was identified to negatively regulate miR-138-5p expression, and miR-138-5p reversed TUG1-induced cell proliferation by targeting HIF1A. Elevated expression of HIF1A predicted a poor survival in LAC. We found that upregulation of TUG1 or downregulation of miR-138-5p was associated with lymph node or distant metastasis and indicated a poor survival in LAC. Yes Reduced expression of TUG1 restrained the growth of LAC cells, while restored expression of TUG1 had the opposite effects. 34608813 TUG1 LncRNA Homo sapiens Cholangiocarcinoma cell lines regulation[Inhibiting miR-29a] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay TUG1 was highly expressed while miR-29a was poorly expressed in cholangiocarcinoma cells. DLRGA confirmed that there was a regulatory relationship between TUG1 and miR-29a. Yes Cell experiments showed that inhibiting TUG1 expression or up-regulating miR-29a expression could inhibit cholangiocarcinoma cells from proliferation and invasion, and promote their apoptosis, while up-regulating TUG1 or inhibiting miR-29a could promote the proliferation and invasion but inhibit the apoptosis. 33173343 hsa_circ_0001679 CircRNA Homo sapiens Acute Lung Injury MLE-12 cells Interaction(circRNA_0001679/miR-338-3p/DUSP16 axis) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA We found that circ_0001679 was overexpressed in lipopolysaccharide (LPS)-stimulated MLE-12 cells. Moreover, circ_0001679 bound to mmu-miR-338-3p and miR-338-3p targeted dual-specificity phosphatases 16 (DUSP16). DUSP16 overexpression reversed the effect of circ_0001679 knockdown in LPS-stimulated MLE-12 cells. Furthermore, circ_0001679 knockdown attenuated lung pathological changes, reduced pulmonary microvascular permeability, and suppressed inflammation in ALI mice. Overall, circ_0001679 knockdown inhibits sepsis-induced ALI progression through the miR-338-3p/DUSP16 axis. Yes circ_0001679 knockdown suppressed apoptosis and proinflammatory cytokine production induced by LPS. 35291714 circLDB1 CircRNA Homo sapiens Hyperlipidemia-Induced Retinal Vascular Dysfunction serum of coronary artery disease patients and aqueous humor Expression(highly expressed) In Vivo Experiment//Transfection//qRT-PCR//MTT//Cell Apoptosis Assay//Microarray Notably, circLDB1 was significantly up-regulated in the serum of coronary artery disease patients and aqueous humor of age-related macular degeneration patients. Yes circLDB1 regulated endothelial cell viability, proliferation, and apoptosis in vitro. 32991963 circLDB2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung non-squamous NSCLC Interaction(miR-346 /LIMCH1) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Invasion Assay//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis CircLDB2 was underexpressed in non-squamous NSCLC and was identified as a bona fide circular transcript. CircLDB2 regulated cell functional behaviors and cisplatin sensitivity by sponging miR-346. LIMCH1 was a direct and functional target of miR-346. Furthermore, circLDB2 acted as a competing endogenous RNA (ceRNA) for miR-346 to induce LIMCH1 expression. Yes Overexpression of circLDB2 impeded cell proliferation, migration, invasion, and enhanced apoptosis and cisplatin sensitivity in vitro, as well as promoted the antitumor effect of cisplatin in vivo. 34096174 TUG1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Regulation[miR-140-5p/PFN2 axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay TUG1 and PFN2 levels were evidently upregulated in OS tissues and cell lines.TUG1 modulated cell proliferation, migration, and invasion via miR-140-5p/PFN2 axis in OS progression, which might trigger the development of therapeutic strategies for the treatment of OS. Yes The knockdown of either TUG1 or PFN2 could restrain cell proliferation, migration, and invasion in OS cells. 31799645 TTTY15 LncRNA Homo sapiens Glioma glioma cells and glioma tissues Interaction(miR-4500 ) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay The expression of TTTY15 in glioma cells and glioma tissues have both increased. The expression levels of TTTY15 and miR-4500 in glioma tissues were inversely correlated. TTTY15 and miR-4500 are mutually targeted. Yes Compared with those of the Control and si-NC groups, the glioma cells in the si-TTTY15 group showed increased level of miR-4500, decreased survival rate, increased apoptosis rate, enhanced cell migration and invasion, increased expression of Bax protein, and decreased expression of Bcl-2, MMP-2 and MMP-9 proteins (P<0.05). 35076913 TUBA5P LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissue Regulation[Wnt/β-catenin signaling pathway Western Blot//Wound Healing Assay//CCK8//qRT-PCR//EdU Staining//Transwell Assay RP11-480I12.5 was Expression[up-expression]regulated in CC tissue compared with normal tissue.Subsequently, the present study investigated the association between RP11-480I12.5 and the epithelial-to-mesenchymal transition (EMT) and Wnt/β-catenin pathways. RP11-480I12.5 promoted EMT through the Wnt/β-catenin pathway. Furthermore, RP11-480I12.5 was associated with clinical stage, tumor size and lymph node metastasis. Yes The present study used in vitro analysis to establish RP11-480I12.5 stable knockdown and overexpressing cell lines, in order to investigate the function and potential molecular mechanism of RP11-480I12.5 in the progression of CC. RP11-480I12.5 promoted the proliferation, migration and invasion of CC cell lines. 31897160 TUBA4B LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and paired adjacent benign tissues,cell lines(MCF-7, ZR-75-1, MDA-MB-231 ,HCC-1937) Interaction[targeting miR-19] CCK8//qRT-PCR//Luciferase Report Assay lncRNA TUBA4B was greatly down-regulated in breast cancer tissues than adjacent non-tumor tissues, lncRNA TUBA4B was significantly decreased in breast cancer cell lines.It is suggested that TUBA4B was downregulated in breast cancer and suppressed proliferation and invasion of breast cancer by targeting miR-19. Yes The functional analysis demonstrated that breast cancer cells proliferation and invasion could be inhibited by overexpression of TUBA4B. 30720178 TUBA4B LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[p15 and p16] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay The results of qRT-PCR revealed that compared with adjacent tissues, the expression of TUBA4B was down-regulated in 47/60 CRC tissues (47/60, 78.3%). LncRNA TUBA4B is down-regulated expression in CRC tissues and cells, which facilitates CRC cell proliferation and suppresses apoptosis by regulating the expressions of p15 and p16. Yes over-expression of TUBA4B inhibited the proliferation and promoted the apoptosis of CRC cells. 32271419 TUBA4B LncRNA Homo sapiens Carcinoma, Ovarian Epithelial tissue specimens and tissue specimens skov3 cell Regulation( ERK and Akt signaling pathways) CCK8//qRT-PCR//Western Blot The expression of lncRNA TUBA4B was significantly decreased in epithelial ovarian cancer tissue specimens. Enforced expression of lncRNA TUBA4B obviously reduced the proliferation of SKOV3 cells, and attenuated the activation of ERK and Akt signaling pathways. The low lncRNA TUBA4B level was closely related with pathological grade, FIGO stage and lymph node metastases, and serum CA125 level. Yes Enforced expression of lncRNA TUBA4B obviously reduced the proliferation of SKOV3 cells, and attenuated the activation of ERK and Akt signaling pathways. 28578489 TTTY15 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tumor tissues and cell lines Interaction( miR-98-5p/CCND2 ) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay The results indicate that TTTY15 and CCND2 expression increased and miR-98-5p expression decreased in gastric cancer tumor tissues and cell lines.TTTY15 knockdown inhibited gastric cancer cell proliferation but promoted apoptosis by sponging miR-98-5p, which acted as a tumor suppressor gene by reducing the expression of its target gene CCND2 in gastric cancer. Yes TTTY15 knockdown inhibited gastric cancer cell proliferation but promoted apoptosis by sponging miR-98-5p, which acted as a tumor suppressor gene by reducing the expression of its target gene CCND2 in gastric cancer. 35266852 TTTY15 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction( let-7a-5p/Wnt1 axis/Wnt/β-catenin pathway) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//BrdU//Transwell Assay It was found that TTTY15 expression was significantly up-regulated in GC tissues and cells, and was associated with advanced TNM stage and poor tumor differentiation. TTTY15 directly targeted let-7a-5p and negatively regulated its expression. Wnt1 was the target gene of let-7a-5p, and TTTY15 could indirectly and positively regulate Wnt1 expression. In conclusion, TTTY15 promotes GC progression, by regulating the let-7a-5p/Wnt1 axis to activate the Wnt/β-catenin pathway. Yes TTTY15 overexpression promoted GC cell proliferation, migration and invasion, the expressions of N-cadherin, Wnt1 and β-catenin protein, and inhibited the apoptosis and E-cadherin expression, while knocking down TTTY15 had the opposite effects. 35287556 TTTY15 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[TBX4] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//MTT//Invasion Assay//Transwell Assay Our results showed that the expression levels of TTTY15 were lower in NSCLC tissues.TTTY15 promotes TBX4 expression via DNMT3A-mediated regulation. Lower TTTY15 expression levels were associated with Tumor-Node-Metastasis (TNM) stage. Yes A TTTY15 knockdown promoted malignant transformation of NSCLC cells. 31311130 TTTY15 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues regulation[ miR-337-3p/JAK2 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In the present study, we demonstrated that the expression level of TTTY15 was significantly upregulated in ESCC tissues, while the expression of miR-337-3p was downregulated. In conclusion, TTTY15 plays an oncogenic role in ESCC by targeting miR-337-3p/JAK2 axis. Yes TTTY15 knockdown could significantly reduce the proliferation, migration and invasion of ESCC cells, and miR-337-3p mimics had similar effects. 32868648 TTTY15 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues,cell lines Interaction[Sponging let-7] qRT-PCR In most patients with PCa, TTTY15 was the most elevated lncRNA located on the Y chromosome.TTTY15 promoted PCa by sponging the microRNA let-7, consequently increasing CDK6 and FN1 expression. FOXA1 is an upstream regulatory factor of TTTY15 transcription. The Y-chromosomal lncRNA TTTY15 was upregulated in most PCa tissues and could promote PCa progression by sponging let-7. Yes Knockout of this lncRNA by two different CRISPR-Cas9 strategies suppressed PCa cell growth both in vitro and in vivo. 30527798 TUBA5P LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells regulation[increasing AKT3 and CDK6 expression] CCK8//qRT-PCR//Colony Formation Assay//Flow Cytometry RP11-480I12.5 expression was significantly upregulated in breast cancer cell lines and clinical breast cancer tissues. Our findings suggested that pseudogene-derived long non-coding RNA (lncRNA) RP11-480I12.5-004 promoted growth and tumorigenesis of breast cancer via increasing AKT3 and CDK6 expression by competitively binding to miR-29c-3p. Yes Knockdown of RP11-480I12.5 markedly suppressed cell proliferation and colony formation, induced cell apoptosis of breast cancer in vitro, and inhibited tumor growth in vivo. 32810693 TTTY15 LncRNA Homo sapiens acute myocardial infarction blood regulation[miR-98-5p/CRP pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA Our results revealed that TTTY15 was upregulated and miR-98-5p was downregulated in AMI patients and H2O2-stimulated myocardial cells.Our research proposed that lncRNA TTTY15 promoted myocardial cell injury by regulating the miR-98-5p/CRP axis, suggesting that TTTY15 might be a potential target for alleviating AMI-caused myocardial cell injury. Yes Knockdown of TTTY15 could alleviate H2O2-stimulated myocardial cell injury in vitro and AMI progression in vivo. 32888161 circDOCK1 CircRNA Homo sapiens Osteosarcoma OS tissues Interaction(miR-339-3p/IGF1R axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Invasion Assay//Colony Formation Assay//Migration Assay//qRT-PCR//FISH//RIP//RNA-seq//Luciferase Report Assay//Cell Proliferation Assay//IHC//EdU Staining CircDOCK1 expression remained stable in the cytoplasm and was higher in OS tissues and cells than in the corresponding controls.In the U2OS and MG63 cell lines, circDOCK1 modulated tumor progression by regulating IGF1R through sponging of miR-339-3p. Additionally, in the U2OS/DDP and MG63/DDP cell lines, cisplatin sensitivity was regulated by circDOCK1 via the miR-339-3p/IGF1R axis. Yes Overexpression of circDOCK1 increased oncogenicity in vivo and malignant transformation in vitro. 34876132 TTTY15 LncRNA Homo sapiens Myocardial Infarction Interaction[targeting miR-455-5p ] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay "Suppression of long noncoding RNA TTTY15 attenuates hypoxia-induced cardiomyocytes injury by targeting miR-455-5p. " Yes Silencing TTTY15 prevented hypoxia-induced cell apoptosis and rescued the cell migration and invasion. 30898696 TTTY15 LncRNA Homo sapiens Myocardial Reperfusion Injury H9c2 and HL-1 cells Regulation(miR-374a-5p/FOXO1 axis) Western Blot//Tunel//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//ELISA The results showed that TTTY15 suppresses autophagy and myocardial I/R injury by targeting miR-374a-5p. We found that TTTY15 regulates miR-374a-5p, thus affecting FOXO1 expression and autophagy in myocytes during I/R. Furthermore, in an in vivo mouse model of myocardial I/R injury, suppression of TTTY15 successfully alleviated myocardial I/R injury. Our results reveal a novel feedback mechanism in which TTTY15 regulates miRNA processing and a potential target in myocardial I/R injury. TTTY15 is a promising therapeutic target for treating myocardial I/R injury. Yes Furthermore, in an in vivo mouse model of myocardial I/R injury, suppression of TTTY15 successfully alleviated myocardial I/R injury. 33296140 hsa_circ_0026134 CircRNA Homo sapiens lung non-small cell carcinoma NSCLC tissues and cells Interaction(miR-3619-5p/CHAF1B axis) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Migration Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Our results showed that circ_0026134 was highly expressed in NSCLC tissues and cells.circ_0026134 directly targeted miR-3619-5p, and circ_0026134 regulated CHAF1B expression through miR-3619-5p. CHAF1B was a downstream effector of circ_0026134 in affecting NSCLC cell functional behaviors in vitro. Yes Reduced circ_0026134 expression or miR-3619-5p overexpression inhibited NSCLC cell colony formation, migration, invasion, glycolysis and promoted cell apoptosis in vitro. Additionally, circ_0026134 silencing weakened tumor growth in vivo. 34985193 TTN-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Regulation[TTN-AS1-miR-376b-3p-KLF12 axis] qRT-PCR Using qRT-PCR examination, we found that TTN-AS1 was expressed at a higher level in GC tissues and cell lines compared to the normal controls. Similarly, the role of TTN-AS1-miR-376b-3p-KLF12 axis in GC progression was analyzed and validated. Kaplan-Meier analysis of GC patients revealed the negative correlation between TTN-AS1 expression and the overall survival. Yes The experimental results revealed that knockdown of TTN-AS1 obviously inhibited GC cell proliferation, induced cell apoptosis and impaired cell migration and invasion. 30943745 TTN-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-499a-5p/ZEB1/CDX2 axis) IHC//Transwell Assay//Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//ChIP Clinical tissue and cellular experiments also confirmed the elevation of TTN-AS1 in GC tissues and cells. Functionally, TTN-AS1 could upregulate ZEB1 expression by binding to miR-499a-5p. In addition, in vitro experiments demonstrated that ZEB1 targeted and activated CDX2 transcription and promoted CDX2 expression; silencing CDX2 inhibited malignant phenotypes of AGS and NCI-N87 cells. Bioinformatics analysis depicted increased TTN-AS1 in GC which shared correlation with poor prognosis. Yes Functionally, TTN-AS1 could upregulate ZEB1 expression by binding to miR-499a-5p. In addition, in vitro experiments demonstrated that ZEB1 targeted and activated CDX2 transcription and promoted CDX2 expression; silencing CDX2 inhibited malignant phenotypes of AGS and NCI-N87 cells. Furthermore, Exo-TTN-AS1 promoted GC cell growth and migration by promoting CDX2 expression. Exosomal TTN-AS1 from GC cells could also promote metastasis of GC in vivo. 36214926 TTN-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues regulation[miR-524-5p,RRM2 ] CCK8//qRT-PCR//Luciferase Report Assay//BrdU//Transwell Assay The expression of TTN-AS1 in BC tissues was significantly higher than that in normal tissues, and its high expression was correlated with adverse pathological indicators. TTN-AS1 exerts oncogenic function in BC by repressing miR-524-5p and increasing the expression of RRM2. Yes Overexpression of TTN-AS1 significantly promoted the proliferation, migration and invasion of BC cells. TTN-AS1 knockdown suppressed the malignant phenotypes of BC cells. 32547107 TUBA5P LncRNA Homo sapiens Breast Neoplasms BC tissue samples and BC cell lines regulation[miR-490-3p-AURKA-Wnt/β-Catenin Axis] qRT-PCR//Transwell Assay RP11-480I12.5 expression was upregulated in data from both the TCGA database and our own database.Our findings indicate that the lncRNA RP11-480I12.5 promotes the proliferation, migration, and invasion of BC cells through the miR-490-3p-AURKA-Wnt/β-catenin axis, which may serve as a therapeutic target in the future. Moreover, Kaplan-Meier and Cox proportional hazard analyses indicated that high RP11-480I12.5 expression was related to poor overall survival. Yes Moreover, RP11-480I12.5 promoted the proliferation, migration, and invasion of BC. 32733789 Tug1 LncRNA Rattus norvegicus Acute Kidney Injury serum of I/R-treated rats Interaction(miR-29/PTEN ) RNA Pull-Down//Western Blot//Tunel//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//IF In vivo, the levels of BUN, SCr and MDA in the serum of I/R-treated rats were increased while SOD level and autophagosomes were reduced, tubule epithelial cells were necrotic, and TUG1 was upregulated in renal tissues of I/R-treated rats, which were all reversed in rats in the ko-TUG1 group.TUG1 could competitively bind to miR-29 to promote PTEN expression. Yes In vivo, the levels of BUN, SCr and MDA in the serum of I/R-treated rats were increased while SOD level and autophagosomes were reduced, tubule epithelial cells were necrotic, and TUG1 was upregulated in renal tissues of I/R-treated rats, which were all reversed in rats in the ko-TUG1 group. Autophagy inhibition (ko-TUG1 + 3-MA group) averted the protective effect of TUG1 knockdown on I/R-treated rats. 34429073 hsa_circ_0069313 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Interaction(miR-325-3p-Foxp3 axis) In Vivo Experiment//Western Blot//Transfection//FISH//qRT-PCR//RIP//Luciferase Report Assay//IHC has_circ_0069313 was upregulated in OSCC tissues and predicts poor prognosis.has_circ_0069313 promotes immunity escape through inhibiting miR-325-3p-induced Foxp3 degradation. has_circ_0069313 is an exosomal circRNA and the transfer of has_circ_0069313 to Treg cells promotes the Treg function through maintaining Foxp3 levels. has_circ_0069313 was upregulated in OSCC tissues and predicts poor prognosis. Yes has_circ_0069313 promotes immunity escape through inhibiting miR-325-3p-induced Foxp3 degradation. has_circ_0069313 is an exosomal circRNA and the transfer of has_circ_0069313 to Treg cells promotes the Treg function through maintaining Foxp3 levels. 35575762 hsa_circ_0027089 CircRNA Homo sapiens Carcinoma, Hepatocellular HBV-related HCC tissues and cells Interaction(miR-136-5p/NACC1 ) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0027089 expression and NACC1 expression were elevated, while miR-136-5p expression was decreased in HBV-related HCC tissues and cells.For mechanism exploration, miR-136-5p was a target of circ_0027089, and miR-136-5p deficiency could reverse the role of circ_0027089 knockdown. Circ_0027089 functioned as an oncogene to promote the development of HBV-related HCC by regulating NACC1 via competitively targeting miR-136-5p. Yes In function, circ_0027089 knockdown inhibited HepG2.2.15 and HepAD38 (tet-off) cell proliferation, migration and invasion but induced cell cycle arrest and apoptosis, while circ_0027089 overexpression played the reversed effects. 34419960 TUG1 LncRNA Homo sapiens Glomerulonephritis Urinary of patients with glomerulonephritides Expression [lower expressed] qRT-PCR Urinary expression of TUG1 was significantly lower in patients with glomerulonephritides, particularly those diagnosed with Focal Segmental Glomerulosclerosis (FSGS). Furthermore, TUG1 levels were associated with urinary expression of podocyte-specific markers and mRNAs associated with mitochondrial biogenesis. Yes Loss of TUG1 expression in urinary sediment was strongly associated with FSGS, highlighting the potential of this lncRNA and its mitochondrial biogenesis-associated targets as non-invasive biomarkers of assessing podocytopathy. 33365127 TUG1 LncRNA Homo sapiens Sarcoma, Ewing Ewing's sarcoma tissues and cells Interaction(miR-199a-3p-MSI2 signaling pathway) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The levels of TUG1 and MSI2 were increased, while the level of miR-199a-3p was decreased in Ewing's sarcoma tissues and cells. TUG1/MSI2 level was negatively correlated with miR-199a-3p level. While TUG1 level was positively correlated with MSI2 level. High expression of TUG1 or MSI2 indicated a decreased overall survival rate of Ewing's sarcoma patients. Yes In Ewing's sarcoma cells, knockdown of TUG1/MSI2 or overexpression of miR-199a-3p inhibited cell proliferation, migration, and invasion, whereas the overexpression of TUG1/MSI2 presented the opposite results. 33780263 TUG1 LncRNA Homo sapiens Cicatrix, Hypertrophic HS tissues Interaction(miR-27b-3p/TAK1/YAP/TAZ pathway) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay TUG1 and TAK1 were upregulated in HS, while miR-27b-3p was downregulated. Overexpression of miR-27b-3p has the same effect on HS as that of TUG1 knockdown. Meanwhile, TUG1 could sponge miR-27b-3p, and TAK1 was the direct target of miR-27b-3p. Furthermore, knockdown of TUG1 significantly suppressed the fibrosis in HS via miR-27b-3p/TAK1/YAP/TAZ axis mediation. LncRNA TUG1 promotes the fibrosis in HS via sponging miR-27b-3p and then activates TAK1/YAP/TAZ pathway, which may serve as a potential target for treatment of HS. Yes Knockdown of TUG1 significantly suppressed the proliferation and migration and induced the apoptosis of HS fibroblasts (HSF). In addition, silencing of TUG1 notably inhibited the extracellular matrix (ECM) biosynthesis in HSF. 33791919 TUG1 LncRNA Homo sapiens gastric adenocarcinoma STAD tissues Interaction(miR-29c-3p) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tube Formation Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//ELISA//IHC//Transwell Assay Bioinformatics analysis revealed that TUG1 was upregulated in STAD, of which expression was negatively and positively correlated with miR-29c-3p and VEGFA, respectively. Mechanistically, the interaction between miR-29c-3p with TUG1 and VEGFA was demonstrated. It was observed that miR-29c-3p could reverse the TUG1-induced promotion effect on cell proliferation, migration, and angiogenesis in STAD. Yes Functional analyses indicated that TUG1 functioned as an oncogene to promote malignant behaviors (proliferation, migration, and angiogenesis) of STAD cells; whereas miR-29c-3p exerted the opposite role. Furthermore, TUG1 overexpression promoted STAD cell proliferation, metastasis, and angiogenesis, whereas VEGFA silence restored these effects, both in vitro and in vivo. 34762771 TUG1 LncRNA Homo sapiens Myocardial Reperfusion CME myocardial tissues Interaction(miR-186-5p/XIAP Axis) In Vivo Experiment//RNA Pull-Down//Transfection//Immunoblotting//qPCR//FISH//Cell Proliferation Assay//Bioinformatics Analysis As a result, TUG1 and XIAP were significantly down-regulated, and the miR-186-5p level was found to be remarkably up-regulated in CME myocardial tissues. Concludingly, the overexpression of TUG1 alleviates NLRP3 inflammasome-mediated cardiomyocyte pyroptosis through targeting the miR-186-5p/XIAP axis in CME-induced myocardial injury. Yes Overexpression of TUG1 alleviated CME-induced myocardial injury and pyroptosis, whereas TUG1 knockdown showed the opposite effects. 34163467 TUG1 LncRNA Homo sapiens Cerebral Ischemia/Reperfusion Injury OGD/R model cells Interaction(miR-493-3p/miR-410-3p) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//ELISA The expression of TUG1 was upregulated, while miR-493-3p or miR-410-3p was downregulated in the serum of CIRI and OGD/R model cells. Meanwhile, knockdown of TUG1 eliminated the suppression in proliferation, the promotion in apoptosis, inflammation and oxidative stress, as well as the cytotoxicity in OGD/R model cells. Interestingly, the inhibition of miR-493-3p or miR-410-3p allayed the above effects. In addition, TUG1 harbored miR-493-3p or miR-410-3p and negatively regulated their expression. Finally, the TUG1 activated JNK and p38 MAPK pathways by sponging miR-493-3p/miR-410-3p. Yes knockdown of TUG1 eliminated the suppression in proliferation, the promotion in apoptosis, inflammation and oxidative stress, as well as the cytotoxicity in OGD/R model cells. Interestingly, the inhibition of miR-493-3p or miR-410-3p allayed the above effects. 34222667 TUG1 LncRNA Homo sapiens Endometrial Neoplasms Ishikawa cells, type I EC patients Regulation( p-AKT/t-AKT) Western Blot//Transfection//Invasion Assay//qRT-PCR//Cell Proliferation Assay//Bioinformatics Analysis//Transwell Assay A significant elevation of TUG1 levels was confirmed in type I EC tissues compared with NNT in the 105 type I EC patients, and high expression of TUG1 was associated with lymph vascular space invasion (LVSI) and lymph node metastasis (LNM). Furthermore, our results showed that the protein levels of E-cadherin increased and N-cadherin decreased significantly, while β-catenin and Vimentin were not significantly altered upon TUG1 silencing in both Hec-1-A and Ishikawa cells. Finally, we found the p-AKT and AKT protein levels, and the rate of p-AKT/t-AKT has a tendency to be down-regulate in Hec-1-A cells, while the AKT pathway was not change significantly in Ishikawa cells after TUG1 knockdown. A significant elevation of TUG1 levels was confirmed in type I EC tissues compared with NNT in the 105 type I EC patients, and high expression of TUG1 was associated with lymph vascular space invasion (LVSI) and lymph node metastasis (LNM). Yes Subsequently, TUG1 knockdown could remarkably inhibit the Hec-1-A and Ishikawa cell invasion and migration in the functional experiment. 36088044 Tug1 LncRNA Mus musculus Diabetic Nephropathies kidney tissue,cell line Interaction[inhibiting miR-21] qRT-PCR//Luciferase Report Assay//RIP//Western Blot First, we have found that the expression of lncRNA TUG1 in db/db DN mice kidney tissue and high glucose-stimulated NRK-52E cells were down-regulated and the overexpression of lncRNA TUG1 could inhibit cell fibrosis of high glucose-stimulated of NRK-52E. Our results indicated that lncRNA TUG1 could indirectly regulated the expression of TIMP3 by targeting miR-21. Yes We have proven that overexpression of lncRNA TUG1 can promote the expression of TIMP3 through targeting the miR-21, thereby inhibiting cell fibrosis in high glucose-stimulated NRK-52E cells and renal fibrosis in DN mice. 31933879 Tug1 LncRNA Rattus norvegicus Spinal Cord Injuries ASCI rats and hypoxic cells Interaction(microRNA-338/BIK axis) RNA Pull-Down//Western Blot//Transfection//Tunel//qRT-PCR//RIP//Luciferase Report Assay Accordingly, we monitored higher expression of TUG1 and BIK, but lower expression of miR-338 in ASCI rats and hypoxic cells. In vitro, hypoxia expedited cell death and c-caspase 3 levels. In vivo, ASCI rats were successfully developed as evidenced by diminished Basso-Beattie-Bresnahan (BBB) locomotor score and enhanced c-caspase 3 and HIF-1α expression. Mechanically, TUG1 interacted with miR-338 to regulate the BIK expression. Yes Nevertheless, TUG1 knockdown mitigated the cell death in ASCI rats and hypoxic cells. 34517787 Tug1 LncRNA Mus musculus Colitis, Ulcerative YAMC cells Regulation(HuR/c-myc axis ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//RIP//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//ELISA TUG1 overexpression promoted cell proliferation and inhibited cell apoptosis in the TNF-α-stimulated YAMC cells. The mechanistic analysis showed that TUG1 positively regulated the HuR/c-myc axis via its interaction with HuR, leading to upregulation of c-myc expression; meanwhile, TUG1 negatively regulated the miR-29b-3p/CDK2 signaling via binding to miR-29b-3p, leading to derepression of CDK2 expression. Further animal experiments showed that TUG1 overexpression attenuated UC progression in the DSS-induced UC in mice. Yes TUG1 overexpression promoted cell proliferation and inhibited cell apoptosis in the TNF-α-stimulated YAMC cells. 33047284 Tug1 LncRNA Mus musculus Diabetic Cardiomyopathies DCM mouse model Interaction(microRNA-145a-5p/Cfl2 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//RIP//qRT-PCR//Luciferase Report Assay//ELISA//Bioinformatics Analysis In the DCM mouse model, lncRNA TUG1 and Cfl2 expression levels were upregulated and miR-145a-5p expression was downregulated. Downregulation of lncRNA TUG1 improved cardiac function and myocardial fibrosis; decreased COL1A1, MMP2, and FN1 expression levels; as well as TNF-α, IL-1β, and Ang-II contents in myocardial tissues of DCM mice. Mechanistically, there was a binding site between lncRNA TUG1 and miR-145a-5p, and miR-145a-5p had a targeting relationship with Cfl2. This study highlights that lncRNA TUG1 sponges miR-145a-5p to aggravate myocardial fibrosis in DCM mice by promoting Cfl2. Yes Downregulation of lncRNA TUG1 improved cardiac function and myocardial fibrosis; decreased COL1A1, MMP2, and FN1 expression levels; as well as TNF-α, IL-1β, and Ang-II contents in myocardial tissues of DCM mice. 36450139 Tug1 LncRNA Mus musculus Pituitary Neoplasms PA tissues Interaction(microRNA-187-3p/TESC axis ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We observed that TUG1 was upregulated in PA tissues and was associated with invasion, knosp grade and tumor size. TUG1 particularly bound to miR-187-3p. In conclusion, this study suggests that TUG1 sponges miR-187-3p to affect PA development by elevating TESC and regulating the NF-κB signaling pathway. Yes TUG1 knockdown inhibited cell proliferation, invasion, migration, and epithelial-mesenchymal transition, promoted apoptosis, and regulated the expression of NF-κB p65 and inhibitor of κB (IκB)-α in PA cells lines in vitro, and also inhibited tumor growth in vivo, and these effects were reversed by miR-187-3p reduction. 34021124 Tug1 LncRNA Mus musculus Reperfusion Injury astrocytes Interaction[sponging mir-145 to up-regulate AQP4] qRT-PCR//Luciferase Report Assay//Tunel//Western Blot In this study, we found that LncRNA TUG1 expression was significantly up-regulated in cultured MA-C cells exposed to OGD/R injury, while similar results were also observed in MCAO model.Moreover, knockdown of TUG1 decreased AQP4 (encoding aquaporin 4) expression to attenuate OGD/R injury. TUG1 could interact directly with miR-145, and down-regulation of miR-145 could efficiently reverse the function of TUG1 siRNA on AQP4 expression. Finally, the TUG1 shRNA reduced the infarction area and cell apoptosis in I/R mouse brains in vivo. In summary, our results suggested that lncRNA TUG1 may function as a competing endogenous RNA (ceRNA) for miR-145 to induce cell damage, possibly providing a new therapeutic target in cerebral ischaemia/reperfusion injury. Yes Mechanistically, knockdown of TUG1 decreased lactate dehydrogenase levels and the ratio of apoptotic cells and promoted cell survival in vitro. 31709761 Tug1 LncRNA Mus musculus Retinal Diseases retina tissue of OIR mice Interaction(miR-145-5p/CCN1) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Tube Formation Assay//Migration Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC//Transwell Assay In the retina tissue of OIR mice, TUG1, miR-145-5p, and CCN1 were differentially expressed.Results from reporter assays indicate direct interactions between TUG1, miR-145-5p, and CCN1. Intravitreal injection of miR-145-5p mimics reduced the degree of retinopathy. Yes Knocking down TUG1 attenuated apoptosis, migration, and angiogenesis induced by hypoxia on HRECs, as did miR-145-5p overexpression. 35445044 Tug1 LncRNA Mus musculus Tibial Fractures healing of closed tibial fractures in mice Interaction(miR-221-3p) In Vivo Experiment//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay Downregulation of TUG1 inhibited osteoblast CP and CM and promoted osteoblast cell apoptosis (CA). Downregulation of miR-221-3p partly reversed the retardation out of downregulating TUG1 on osteoblast CP and CM. Bcl-2 level was higher in the LncRNA TUG1 group compared to the siLncRNA TUG1 and miR-221-3p overexpression groups, with remarkably lower SDF-1 level in the miR-221-3p overexpression group than those in the control, miRNA-NC, and LncRNA TUG1 groups. Yes Cell cycle analysis indicated that miR-221-3p provoked cell cycle arrest in G1 stage of MC3T3-E1 cells. Downregulation of TUG1 inhibited osteoblast CP and CM and promoted osteoblast cell apoptosis (CA). The siLncRNA-NC group had higher anticyclin D1 and D3 levels than the siLncRNA TUG1 group, with a lower CA rate in the former, implying that miR-221-3p overexpression inhibited osteoblast CP and CM and LncRNA TUG1 inhibited CA. 36060124 Tug1 LncRNA Mus musculus Adenomyosis EECs Interaction(EECs via E2F4/KLF5) RNA Pull-Down//IHC//Transwell Assay//Western Blot//Wound Healing Assay//CCK8//FISH//RIP//qRT-PCR//H&E Staining//ELISA//Colony Formation Assay//IF TUG1 expression was elevated in AM mice and patients. Downregulation of TUG1 promoted the recovery of AM mice. Downregulation of TUG1 suppressed proliferation, migration, invasion, EMT, and angiogenesis of EECs. Mechanically, TUG1 suppressed KLF5 transcription by binding to E2F4. Downregulation of KLF5 reversed the inhibitory effect of TUG1 silencing on the functions of EECs. Yes Mechanically, TUG1 suppressed KLF5 transcription by binding to E2F4. Downregulation of KLF5 reversed the inhibitory effect of TUG1 silencing on the functions of EECs. 35298636 Tug1 LncRNA Rattus norvegicus Asthma rat asthma model Interaction(miR-138-5p/E2F3 axis) In Vivo Experiment//Transfection//qRT-PCR//MTT//Luciferase Report Assay//ELISA//Transwell Assay The expression of TUG1, level of serum IgE, inspiratory resistance and expiratory resistance were clearly increased in the rat asthma model in comparison with controls. In addition, TUG1 functioned as a bait of miR-138-5p, and miR-138-5p modulated E2F3 expression. Knockdown of E2F3 hindered the abnormal growth of ASMCs. Moreover, miR-138-5p inhibition or E2F3 overexpression reversed the inhibitory effects of TUG1 knockdown on viability and migration of PDGF-BB-induced ASMCs. Yes Knockdown of TUG1 the viability and migration of PDGF-BB-induced ASMCs and reduced the inspiratory and expiratory resistances. 34539825 TUG1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues,blood Interaction[RUNX2] CCK8//qRT-PCR//Western Blot//Transwell Assay TUG1 expression was found to be significantly higher in osteosarcoma tissues compared with adjacent healthy tissues, and in the plasma of osteosarcoma patients compared with healthy controls. These results suggest that lncRNA TUG1 may promote the development of osteosarcoma by modulating RUNX2 and TUG1 expression, which can serve as prognostic and diagnostic markers for this malignancy. Yes TUG1 overexpression and knockdown respectively increased and reducedosteosarcoma cell viability, migration and invasion. 31555384 hsa_circ_0043688 CircRNA Homo sapiens Keloid keloids samples and fibroblasts Interaction( miR-145-5p/FGF2) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Transwell Assay Increased hsa_circ_0043688 and FGF2, and decreased miR-145-5p in keloids samples and fibroblasts were found. In mechanism, hsa_circ_0043688 modulated FGF2 content via sponging miR-145-5p. Yes Also, hsa_circ_0043688 absence hindered proliferation, invasion, migration, and boost apoptosis of keloid fibroblasts. 35754140 circACSL1 CircRNA Homo sapiens Myocarditis MC patients Interaction(miR-8055/MAPK14) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//RNA-seq//Cell Proliferation Assay//ELISA In this study, we determined a novel circRNA, circACSL1 (ID: hsa_circ_0071542), which was significantly upregulated in the acute phase of MC, and its dynamic change in expression was related to the progression of MC. Mechanistically, circACSL1 acted as a sponge for miR-8055-binding sites to regulate the downstream target MAPK14 expression. Furthermore, overexpression of miR-8055 rescued the pro-inflammatory effects of circACSL1 on HCM, and the upregulation of MAPK14 induced by circACSL1 was attenuated by miR-8055 overexpression. Yes The results revealed that circACSL1 could aggravate inflammation, myocardial injury, and apoptosis in HCM. ? 33986259 TYMSOS LncRNA Homo sapiens Stomach Neoplasms GC cells Interaction(miR-4739/ZNF703 ) RNA Pull-Down//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay In brief, TYMSOS was highly expressed in GC cells, and TYMSOS silence inhibited GC cell proliferation, migration, and invasion while elevating cell apoptosis. Functionally, TYMSOS functioned as a competing endogenous RNA to posttranscriptionally modulate GC progression. TYMSOS interacted with miR-4739 to regulate its target gene zinc finger protein 703. Yes In brief, TYMSOS was highly expressed in GC cells, and TYMSOS silence inhibited GC cell proliferation, migration, and invasion while elevating cell apoptosis. 33847425 TYMSOS LncRNA Homo sapiens Thyroid Neoplasms THCA cells and tissues Interaction(miR-130a-5p/MARCKSL1 / PI3K/Akt signaling pathway) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay TYMSOS and myristoylated alanine rich protein kinase C substrate like 1 (MARCKSL1) were upregulated whereas miR-130a-5p was downregulated in THCA cells and tissues.Collectively, TYMSOS facilitates THCA progression by sponging miR-130a-5p and upregulating MARCKSL1 to activate the PI3K/Akt signaling pathway, providing new avenues for THCA treatment. Yes The results of loss-of-function assays showed that TYMSOS knockdown inhibited cell metastasis and epithelial-mesenchymal transition (EMT) in THCA. 36374807 TYMSOS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell Interaction(miRNA-214-3p/NCAPG axis) IHC//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay In summary, our findings demonstrated that the crucial roles of the FOXM1/lncRNA-TYMSOS/miRNA-214-3p/NCAPG axis in NSCLC may shed light on how NCAPG may act as a therapeutic target for NSCLC. Yes Knockdown of long noncoding RNA (lncRNA) thymidylate synthetase opposite strand (TYMSOS) also inhibits the NSCLC cell proliferation, migration, and self-renewal abilities. 35211508 TUSC8 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues regulation[miR-190b-5p/MYLIP axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//Transwell Assay Here, we found that TUSC8 was significantly down-regulated in breast cancer tissues and its high expression predicted better prognosis of breast cancer patients.Taken together, these results suggested that TUSC8 inhibited breast cancer growth and metastasis via miR-190b-5p/MYLIP axis, providing us new insights into developing potential therapeutic targets for breast cancer patients. Here, we found that TUSC8 was significantly down-regulated in breast cancer tissues and its high expression predicted better prognosis of breast cancer patients. Yes Functionally, knock-down of TUSC8 drastically promoted the proliferation, migration and invasion of breast cancer cells in vitro and facilitated tumorigenicity and metastasis in vivo. 32039833 TUSC8 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(VEGFA ) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay Our data showed that long non-coding RNA (LncRNA) TUSC8 mRNA expression in NSCLC tissue specimens was remarkably lower than that in adjacent ones. A binding relationship between LncRNA TUSC8 and its downstream target gene VEGFA was verified by luciferase assay. A great link was found between LncRNA TUSC8 and tumor size, TNM stage and overall survival rates of patients with Lung cancer (LCa).  Yes The proliferation of NSCLC cells remarkably reduced after overexpression of LncRNA TUSC8 compared with the control group pcDNA3.1-NC, while cell apoptosis indicated an opposite trend. 34076977 TUSC8 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines regulation[miR-197-3p/EHD2 axis] Western Blot//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay In the present study, it was observed that TUSC8 was markedly downregulated in OS tissues and cell lines. On the whole, these findings indicate that TUSC8 functions as a competing endogenous RNA (ceRNA) to suppress OS cell growth and EMT via the miR‑197‑3p/EHD2 axis. Yes Functional experiments demonstrated that the overexpression of TUSC8 significantly suppressed the proliferation, migration, invasion and epithelial?mesenchymal transition (EMT), whereas it accelerated the apoptosis of OS cells. 32945345 TUSC8 LncRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues Regulation(VEGFA) qRT-PCR//Colony Formation Assay TUSC8 was downregulated in esophageal cancer tissues compared with normal ones. Identically, decreased TUSC8 expression was detected in esophageal cancer cell lines compared with control cells. VEGFA was confirmed to be a target gene of TUSC8. Overexpression of VEGFA could reverse the regulatory effects of TUSC8 on esophageal cancer cell proliferation and migration. Low TUSC8 expression predicted poor prognosis in patients with esophageal cancer. Yes Knockdown of TUSC8 promoted the proliferative and migratory abilities in OE19 cells, whereas overexpression of TUSC8 resulted in opposite results in TE-1 cells. 34659529 TUSC8 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Regulation[miR-641/PTEN axis] qRT-PCR We found that the expressions of TUSC8 and PTEN were decreased in CC tissues, whereas miR-641 expression was increased. In addition, TUSC8 and PTEN were upstream and downstream target molecule of miR-641, respectively. Overexpression of TUSC8 promoted PTEN expression, and suppressed the invasion and migration of Hela cells, whereas miR-641 mimic treatment changed the effects. These results demonstrated that overexpression of TUSC8 could inhibit the invasion and migration of CC cells by upregulating PTEN via miR-641. Yes Inhibition of miR-641 suppressed the migration and invasion of Hela cells. 31033083 TUSC7 LncRNA Homo sapiens Colorectal Neoplasms cell lines(HCT116, COLO205, HT29, SW480 and CaCO-2 ) Expression[Expression[lower expressed]-expression] CCK8//Wound Healing Assay//Western Blot In the present study, we observed that the expression of TUSC7 was decreased in CRC cells compared to the expression in the normal colon epithelial cell line NCM460. Yes Moreover, overexpression of TUSC7 inhibited CRC cell proliferation, metastasis, invasion and EMT. These findings indicated that TUSC7 is involved in CRC development. 31002365 UBA6-DT LncRNA Homo sapiens Colonic Neoplasms 17 pairs of COAD samples , cells Regulation Bioinformatics Analysis In cell function experiments, UBA6-AS1 knockdown attenuated cell proliferation capacity. Yes In cell function experiments, UBA6-AS1 knockdown attenuated cell proliferation capacity. 36119534 TUSC7 LncRNA Homo sapiens Colorectal Neoplasms cell lines regulation[miR-23b/PDE7A Axis] Western Blot//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Transwell Assay We observed that the expression of TUSC7 was markedly decreased in colorectal cancer cell lines.We demonstrated the expression of TUSC7 suppressed colorectal cancer progression through the TUSC7/miR-23b/PDE7A axis, suggesting that TUSC is a potential target for therapeutic intervention in colorectal cancer. Moreover, the lower expression of TUSC7 was correlated with advanced clinical grades and poorer survival and may be an independent risk factor for colorectal cancer. Yes Moreover, the expression of TUSC7 inhibited cell proliferation, invasion and epithelial-to-mesenchymal transition (EMT), while it facilitated apoptosis through competitively binding miR-23b. 33370523 hsa_circ_0004058 CircRNA Homo sapiens senile cataract SRA01/04 cells Interaction(miR-186/ATG7 axis) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay Hsa_circ_0004058 was notably down-regulated in H2O2-treated SRA01/04 cells. Moreover, hsa_circ_0004058 overexpression reduced apoptotic cells and the expression of Cleaved-caspase-3 and Bax, and enhanced Bcl-2 expression in H2O2-treated SRA01/04 cells. However, hsa_circ_0004058 silencing caused the opposite results. Hsa_circ_0004058 up-regulation accelerated the expression of autophagy-related proteins LC3-II/LC3-I and Beclin-1 in H2O2-treated SRA01/04 cells, which was partly abolished by 3-Methyladenine (autophagy inhibitor). Additionally, hsa_circ_0004058 functioned as a competing endogenous RNA to competitive binding miR-186, and thus accelerated the expression of its down-stream target, ATG7. Hsa_circ_0004058 promoted autophagy of SRA01/04 cells by regulating miR-186/ATG7 axis. In conclusion, these data demonstrates that hsa_circ_0004058 inhibits apoptosis of SRA01/04 cells by promoting autophagy, which attributes to regulate miR-186/ATG7 axis. Yes Moreover, hsa_circ_0004058 overexpression reduced apoptotic cells and the expression of Cleaved-caspase-3 and Bax, and enhanced Bcl-2 expression in H2O2-treated SRA01/04 cells. However, hsa_circ_0004058 silencing caused the opposite results. 34375588 TUSC7 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial ovarian cancer tissues Expression(highly expressed) qRT-PCR//Wound Healing Assay//Western Blot LOC285194 expression level was higher in ovarian cancer tissues compared to control. Lymph node metastasis and high LOC285194 expression were significant prognostic factors of mortality (HR=4.614 and 5.880; p=0.026 and p=0.002, respectively). Knockdown of LOC285194 decreased cell migration and proliferation, enhanced reactive oxygen species production and resulted in increased levels of proteins of the extrinsic apoptotic signaling pathway. Overall survival was significantly shorter in patients with high LOC285194 expression. Yes Knockdown of LOC285194 decreased cell migration and proliferation, enhanced reactive oxygen species production and resulted in increased levels of proteins of the extrinsic apoptotic signaling pathway. 34972707 TUSC7 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues regulation[miR-616-5p/GSK3β pathway] CCK8//qRT-PCR//Luciferase Report Assay In this study, we first found that TUSC7 was significantly reduced in ovarian cancer tissues, which was associated with advanced stage and poor diagnosis for ovarian cancer patients. Finally, we proved that TUSC7 regulated cell proliferation, invasion and migration via miR-616-5p/GSK3β signaling pathway in SKOV3 cells. In this study, we first found that TUSC7 was significantly reduced in ovarian cancer tissues, which was associated with advanced stage and poor diagnosis for ovarian cancer patients. Yes Of note, we found that TUSC7 overexpression inhibited cell proliferation, invasion and migration in SKOV3 cells. 32706063 TUSC7 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and cell lines Interaction[targeting miR-616] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay TUSC7 was downexpressed in EC tissues and cell lines,Mechanistic investigations demonstrated that TUSC7 can interact with miR-616 and decrease its expression, thereby upregulating the expression of miR-616's targets SOCS4 (SOCS5). Yes TUSC7 was downexpressed in EC tissues and cell lines, and TUSC7 upregulation could remarkably inhibit cell proliferation, cycle progression and metastasis in EC cells. 31200002 TUSC7 LncRNA Homo sapiens Osteosarcoma Osteosarcoma tissues Interaction[targeting miR-211] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Bioinformatics analysis showed that TUSC7 specifically binds to miR-211. MiR-211 was up-regulated in osteosarcoma and negatively correlated with the expression of TUSC7.miR-211 expression was inhibited remarkably by TUSC7 overexpression and the reciprocal inhibition exists between TUSC7 and miR-211. RNA pull-down and luciferase reporter assays were used to validate the sequence-specific correlation between miR-211 and TUSC7. Yes TUSC7 inhibited the proliferation, migration of osteosarcoma cells and promoted cellular apoptosis, which is largely mediated by miR-211. 31652435 TUSC7 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines regulation[miR-181a/RASSF6 axis] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The present study revealed that TUSC7 expression was downregulated in OS tissues and cell lines compared with in normal tissues and cell lines.Overall, the present study demonstrated that the tumor suppressor role of TUSC7 in OS progression was mediated through the miR‑181a/RASSF6 axis, which may represent a new therapeutic target for OS. Yes Functionally, the current results revealed that overexpression of TUSC7 inhibited OS cell proliferation, migration and invasion, while promoting apoptosis in vitro and in vivo. 33416181 TUSC7 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues regulation[miR-375] qRT-PCR//MTT//Transwell Assay lncRNA TUSC7 in osteosarcoma tissue was significantly lower than that of adjacent tissues, while miR-375 levels were significantly higher than that of adjacent tissues; the two levels have a negative correlation. In conclusion, lncRNA TUSC7 inhibited the proliferation and migration of MG63 osteosarcoma cells by regulating miR-375. Yes lncRNA TUSC7 mimic inhibited MG63 proliferation and migration abilities. 32934702 U90926 LncRNA Rattus norvegicus Ischemic Stroke ischemic brain tissue Interaction(MDH2/CXCL2 axis) In Vivo Experiment//Flow Cytometry//qRT-PCR//FISH//Microarray Microglial U90926 knockdown could reduce the infiltration of neutrophils into ischemic lesion site, which might be attributed to the downregulation of C-X-C motif ligand 2 (CXCL2). Mechanistically, U90926 directly bound to malate dehydrogenase 2 (MDH2) and competitively inhibited the binding of MDH2 to the CXCL2 3' untranslated region (UTR), thus protecting against MDH2-mediated decay of CXCL2 mRNA. Taken together, our study demonstrated that microglial U90926 aggravated ischemic brain injury via facilitating neutrophil infiltration, suggesting that U90926 might be a potential biomarker and therapeutic target for ischemic stroke. Yes Microglial U90926 knockdown could reduce the infiltration of neutrophils into ischemic lesion site, which might be attributed to the downregulation of C-X-C motif ligand 2 (CXCL2). 33895326 UBA6-DT LncRNA Homo sapiens Ovarian Neoplasms OC tissues Interaction(RBM15/IGF2BP1) qRT-PCR//MeRIP Here, we found that UBA6-AS1 directly associated with UBA6 mRNA and inhibited its decay. Moreover, UBA6-AS1 positively correlated with UBA6 expression in OC tissues. Downregulation of UBA6-AS1 or UBA6 expression indicated poor. Yes Functionally, UBA6-AS1 suppressed the proliferation, migration and invasion of OC cells via UBA6. 34951345 hsa_circ_0001971 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck saliva Interaction(hsa_circ_0001971/microRNA-186/SHP2 and hsa_circ_0001874/microRNA-297/PLK1) Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay it was identified that circ_0001847 and circ_0001971 respectively sponged the expression of miR-296 and miR-186 via binding to these miRNAs. Also, SHP2 mRNA and PLK1 mRNA were respectively targeted by miR-186 and miR-296-5p. We also established two signaling pathways, i.e., circ_0001971/miR-186/SHP2 and circ_0001874/miR-296-5p/PLK1, and validated the synergistic effect of circ_0001971 and circ_0001874 via observing their positive effect on cell proliferation and negative effect on cell apoptosis. The expression of miR-186 and miR-296-5p was generally lower in saliva of OSCC patients compared with that in OLK patients, while the expression of miR-186 and miR-296-5p was specifically up-regulated in saliva of OSCC patients. the finding of this study demonstrated that the relative level of hsa_circ_0001971 and hsa_circ_0001874 were different in the saliva of OSCC patients and could be used as predictive biomarkers for the development of OSCC. Yes By observing the effect of different miRNAs on the levels of circ_0001847 and circ_0001971, it was identified that circ_0001847 and circ_0001971 respectively sponged the expression of miR-296 and miR-186 via binding to these miRNAs. 34663837 UBE2R2-AS1 LncRNA Homo sapiens Glioma glioma tissues Interaction(miR-877-3p ) In Vivo Experiment//qRT-PCR//Bioinformatics Analysis In this study, it was further found that the expression of UBE2R2-AS1 in glioma tissues was decreased significantly, and gradually decreased with increasing clinical stage.The analysis of data from TCGA also showed that patients with high UBE2R2-AS1 levels or low miR-877-3p expression were more likely to have good survival outcomes. In this study, it was further found that the expression of UBE2R2-AS1 in glioma tissues was decreased significantly, and gradually decreased with increasing clinical stage. Chi-square analysis showed that the expression of UBE2R2-AS1 was significantly correlated with the WHO stage of tumor and epilepsy. Using Kaplan-Meier univariate survival analysis, it was found that the expression of UBE2R2-AS1 correlated positively with the overall survival of patients with glioma, while multiple Cox regression analysis showed that the expression of UBE2R2-AS1 correlated positively with the overall survival of patients with glioma as a protective factor for glioma prognosis. Yes Further construction of a glioma xenograft model in nude mice showed that UBE2R2-AS1 overexpression inhibited the growth of tumors, and the inhibition of miR-877-3p expression had a similar effect. Simultaneous UBE2R2-AS1 overexpression and miR-877-3p inhibition further decreased the growth rate of tumors in nude mice. 33528791 uc.339 LncRNA Homo sapiens Adenocarcinoma of Lung LLC cells and tissues Interaction(miR-339/SLC7A11 Axis) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, we identified Uc.339 as upregulated in patients with lung adenocarcinoma. RAP-qPCR proved that LncRNA Uc.339 competitively binds to pri-miR-339 and inhibits the production of mature miR-339. The interaction between miR-339 and SCL7A11 was confirmed by luciferase reporter assay. Yes The Uc.339/miR-339/SLC7A11 axis regulated the proliferation, migration and invasion of A549 and H1299cells in vitro by affecting ferroptosis. Finally, in mouse xenograft models, knocking down Uc.339 in LLC cells was able to inhibits tumor growth by blocking the axis of Uc.339/miR-339/SLC7A11 in vivo, but miR-339 inhibitors could reverse this inhibition. 35399708 uc.187 LncRNA Mus musculus Pre-Eclampsia placenta Expression[highly expressed] qRT-PCR//Western Blot We found uc.187 was elevated in the placenta of PE rats. Yes In vitro experiments demonstrated that high levels of uc.187 lead to decreased trophoblast invasion. In addition, our results revealed that uc.187 had high expression in PE and fetal growth restricted cells, but low expression in placental site trophoblastic tumors compared with the control groups. 31950140 circITCH CircRNA Homo sapiens Hirschsprung Disease HSCR patients and cells Interaction(miR-146b-5p/RET axis) Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Circ-ITCH and RET expressions were downregulated in HSCR patients and cells, while the miR-146b-5p expression was upregulated. Circ-ITCH negatively regulated miR-146b-5p expression. MiR-146b-5p overexpression abolished the promoting effects of circ-ITCH overexpression on cell proliferation and migration. MiR-146b-5p inhibited RET expression. RET overexpression eliminated the inhibitory effects of miR-146b-5p overexpression on cell proliferation and migration. Yes Circ-ITCH overexpression facilitated cell proliferation, migration, and activated MAPK pathway, which were reversed by circRNA-ITCH knockdown. 35091706 UBR1 LncRNA Homo sapiens Lung Neoplasms LC cells Interaction(microRNA-545-5p/SSFA2 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Then it was found that circ-UBR1 was up-regulated in LC cells, and had microRNA (miR)-545-5p binding sites. Knockdown circ-UBR1 or enhancive miR-545-5p repressed A549 cell proliferation, migration, and invasion, but accelerated apoptosis. After transfection with circ-UBR1 low expression vector, upregulation of SSFA2 apparently reversed the depression of reduced circ-UBR1 on cell proliferation, migration, and invasion, and the promotion of cell apoptosis. Yes Knockdown circ-UBR1 or enhancive miR-545-5p repressed A549 cell proliferation, migration, and invasion, but accelerated apoptosis. After transfection with circ-UBR1 low expression vector, upregulation of SSFA2 apparently reversed the depression of reduced circ-UBR1 on cell proliferation, migration, and invasion, and the promotion of cell apoptosis. Further tumor xenograft experiments in nude mice also confirmed that knockdown of circ-UBR1 could increase the expression of miR-545-5p, but decrease the expression of SSFA2, thus alleviating the progression of LC in vivo. 34787049 UBL7-DT LncRNA Homo sapiens Glioblastoma U138MG cells Expression(Among them, 27 lncRNAs were identified as therapy-resistant lncRNAs that remained dysregulated after both radiotherapy and chemoradiotherapy; while 21 lncRNAs were identified as therapy-sensitive lncRNAs whose expressions were reversed by both radiotherapy and chemoradiotherapy.) Western Blot//Transfection//qRT-PCR//Microarray//Cell Proliferation Assay We identified 51 lncRNAs aberrantly expressed in GBM specimens compared with either normal brain samples or epilepsy non-tumor brain samples. Among them, 27 lncRNAs were identified as therapy-resistant lncRNAs that remained dysregulated after both radiotherapy and chemoradiotherapy; while 21 lncRNAs were identified as therapy-sensitive lncRNAs whose expressions were reversed by both radiotherapy and chemoradiotherapy. We further investigated the potential functions of the therapy-resistant and therapy-sensitive lncRNAs and demonstrated their relevance to cell proliferation. We also found that the expressions of several lncRNAs, including SNHG1 and UBL7-AS1, were positively correlated with cell-cycle genes' expressions. Finally, we experimentally confirmed the function of a therapy-resistant lncRNA, SNHG1, and a therapy-sensitive lncRNA, UBL7-AS1, in promoting cell proliferation in GBM U138MG cells. Our in vitro results demonstrated that knockdown of SNHG1 and UBL7-AS1 showed an additive effect in reducing cell proliferation in U138MG cells. Yes Among them, 27 lncRNAs were identified as therapy-resistant lncRNAs that remained dysregulated after both radiotherapy and chemoradiotherapy; while 21 lncRNAs were identified as therapy-sensitive lncRNAs whose expressions were reversed by both radiotherapy and chemoradiotherapy. 35313638 UBE2R2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[EGFR-PI3K-AKT signaling pathway] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay UBE2R2-AS1 is increased in HCC tissues and cell lines. Regarding the mechanism, UBE2R2-AS1/miR-302b/EGFR established the ceRNA network involved in the modulation of cell progression of HCC cells via activation of PI3K-AKT signaling pathway. Increased expression of UBE2R2-AS1 is associated with large tumor size, multiple tumor number, advanced TNM stage, and poor survival of HCC patients. Yes Functional experiments showed that knockdown UBE2R2-AS1 inhibited HCC growth and metastasis through in vitro and in vivo experiments. 32835579 UBE2R2-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Wound Healing Assay//Western Blot Compared with adjacent normal tissues, UBE2R2-AS1 expression was significantly suppressed in cancer tissues correlated with the increasing stage. Yes UBE2R2-AS1 suppressed cell proliferation and enhanced apoptosis, as well as decreased cell invasion and wound healing in cervical cancer cell lines. 33336075 UBE2R2-AS1 LncRNA Homo sapiens Glioma glioma tissue Regulation[miR-877-3p/TLR4 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay In this study, we identified a novel lncRNA, UBE2R2-AS1, which was dramatically downregulated in glioma compared with normal tissue, by performing microarray detection of six pairs of glioma samples and adjacent normal tissues. Furthermore, lncRNA UBE2R2-AS1 suppressed glioblastoma cell growth, migration, and invasion, as well as promoting cell apoptosis by targeting miR-877-3p/TLR4 directly. Yes Furthermore, lncRNA UBE2R2-AS1 suppressed glioblastoma cell growth, migration, and invasion, as well as promoting cell apoptosis by targeting miR-877-3p/TLR4 directly. 31123407 UBE2R2-AS1 LncRNA Homo sapiens Prostatic Neoplasms PC tissues and cells Expression(highly expressed) qRT-PCR Our data showed that UBE2R2-AS1 expression was significantly upregulated in PC tissues compared with that in adjacent tissues. The high levels of UBE2R2-AS1 were associated with high Gleason score, advanced clinical T stage, lymph node metastasis and poor prognosis. Yes Knockdown of UBE2R2-AS1 suppressed cell proliferation, migration and invasion, induced cell cycle G0/G1 arrest and apoptosis in PC cells, along with decreased expression of PCNA, CDK4, Cyclin D1, Bcl-2, N-cadherin and Vimentin, and increased E-cadherin expression. Overexpression of UBE12R2-AS1 obtained the opposite results in PC cells. 35916204 UBAC2 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines regulation[BCRC-3/miRNA-182-5p/p27 axis] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//CCK8//RIP//FISH//Luciferase Report Assay//Colony Formation Assay//IF In this study, we found that both UBAC2 mRNA and protein levels were upregulated in BC tissues and cell lines, and knockdown of UBAC2 inhibited BC cells proliferation both in vitro and in vivo. Our findings highlight a novel mechanism of UBAC2 in regulating p27 through affecting the function of BCRC-3, and provide a research basis for the diagnostic and therapeutic application of BC. Meanwhile, Kaplan-Meier survival plots of 406 BC cases from TCGA database showed that higher expression of UBAC2 in BC patients was associated with lower survival rate. Yes In this study, we found that both UBAC2 mRNA and protein levels were upregulated in BC tissues and cell lines, and knockdown of UBAC2 inhibited BC cells proliferation both in vitro and in vivo. 32913183 UBE2Q2 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-370-3p-STAT3 axis ) colony Formation Assay//RNA Pull-Down//Western Blot//Transfection//Colony Formation Assay//qRT-PCR//RIP//PCR//IP//Transwell Assay//IF We found that circUBE2Q2 was significantly upregulated in GC tissues and cell lines.A series of experiments were performed to confirm that circUBE2Q2 regulates GC progression via the circUBE2Q2-miR-370-3p-STAT3 axis and promotes tumor metastasis through exosomal communication. Yes Knockdown of circUBE2Q2 inhibited proliferation, migration, invasion, and glycolysis, and increased autophagy in vitro. In addition, knockdown of circUBE2Q2 inhibited GC tumorigenicity and metastasis potential in vivo. 34611143 UBE2G1 CircRNA Homo sapiens Osteoarthritis OA tissues regulation[miR-373/HIF-1a axis] Western Blot//qPCR//RIP//Cell Apoptosis Assay//PCR//IP//IF In the present study, the expression levels of circRNA-UBE2G1 and HIF-1a were significantly increased in OA tissues, whereas miR?373 expression was downregulated.Collectively, our data suggest that circRNA-UBE2G1 facilitates the progression in the LPS-induced OA cell model via regulating the miR‑373/HIF-1a axis. Yes Function assays showed that circRNA-UBE2G1 inhibition reduced the effects of LPS on C28/I2 cells viability and apoptosis. 32476580 UBE2D2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-376a-3p/EIF4G2 axis) Western Blot//Transfection//qPCR//Flow Cytometry//RIP//PCR//IP//IF The results manifested the up-regulation of circ-UBE2D2 expression in NSCLC tissues and cells. Interestingly, circ-UBE2D2 directly targeted miR-376a-3p and up-regulated miR-376a-3p restrained proliferation, migration and invasion, but accelerated apoptosis of NSCLC cells. More importantly, EIF4G2 was the target of miR-376a-3p, and overexpression of EIF4G2 reversed the effects of circ-UBE2D2 downregulation on proliferation, migration, invasion and apoptosis of NSCLC cells. Yes Circ-UBE2D2 promoted the proliferation, migration and invasion, but repressed apoptosis of NSCLC cells. 35196197 UBE2CP3 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues Interaction(miR-138-5p/ITGA2 axis) Other In this study, we revealed that lncRNA UBE2CP3 was aberrantly upregulated in multiple independent gastric cancer cohorts, and its overexpression was clinically associated with poor prognosis in GC. Mechanismly, a novel dysregulated ceRNA network UB2CP3/miR-138-5p/ITGA2 was identified in GC by transcriptome sequencing. Furthermore, rescue assay further confirmed that UBE2CP3 mainly promoted GC progression through miR-138-5p/ITGA2 axis. In this study, we revealed that lncRNA UBE2CP3 was aberrantly upregulated in multiple independent gastric cancer cohorts, and its overexpression was clinically associated with poor prognosis in GC. Yes UBE2CP3 was mainly located in cytoplasm and promoted migratory and invasive capacities of GC cells in vitro and in vivo. 34274947 UBAP2 CircRNA Homo sapiens Carcinoma, Hepatocellular 20 paired samples of HCC and healthy tissue Interaction(miR-1294) Western Blot//Migration Assay//CCK8//RIP//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay CircUBAP2 was highly upregulated in most HCC tissues and was associated with poor prognosis. Furthermore, we found that circUBAP2 upregulated c-Myc expression by sponging miR-1294, thus contributing to hepatocarcinogenesis. Inhibiting circUBAP2 expression in HCC attenuated the oncogenic effects of c-Myc. CircUBAP2 was highly upregulated in most HCC tissues and was associated with poor prognosis. HCC patients with high circUBAP2 expression had greater vascular invasion and worse differentiation. Yes Functionally, circUBAP2 overexpression enhanced HCC cell proliferation, migration and invasion and inhibited apoptosis. 34314478 UBAP2 CircRNA Homo sapiens Ovarian Neoplasms OC tissues Interaction[sponging microRNA-144] CCK8//qRT-PCR//Luciferase Report Assay QRT-PCR results showed that circUBAP2 was highly expressed in OC tissues.The Dual-Luciferase reporter gene assay demonstrated that circUBAP2 could bind to microRNA-144. Meanwhile, circUBAP2 negatively regulated microRNA-144 expression in OC cells. Besides, the promotive effects of circUBAP2 on the proliferation and migration of OC cells were reversed by microRNA-144 overexpression. MicroRNA-144 was lowly expressed in OC tissues, which was negatively correlated with TNM stage of OC patients. The Dual-Luciferase reporter gene assay confirmed the binding condition between CHD2 and microRNA-144. CHD2 expression was negatively regulated by microRNA-144 in OC cells. QRT-PCR results showed that circUBAP2 was highly expressed in OC tissues, and its expression was negatively correlated with TMN stage and five-year survival of OC patients. Yes Overexpression of circUBAP2 significantly promoted the proliferative and migratory abilities of OC cells. 31539115 UBAP2 CircRNA Homo sapiens Prostatic Neoplasms PCa cell lines and clinical tissues Interaction(miR-1244/MAP3K2 axis) Western Blot//Transfection//qPCR//PCR//IF circUBAP2 expression was identified to be upregulated in four PCa cell lines and clinical tissues by using reverse transcription-quantitative PCR analysis. Yes Binding sites analysis and luciferase reporter gene assay indicated that the microRNA(miR)-1244/MAP3K2 axis was the target of circUBAP2. Gain-of-function assays revealed that circUBAP2 promoted the proliferation of PCa cells by sponging miR-1244 and promoting the MAP3K2 axis. 33968202 UBAP2 LncRNA Homo sapiens Shock, Cardiogenic macrophage NR8383 cells Regulation Western Blot//Transfection//Flow Cytometry//qRT-PCR//Transwell Assay In addition, circUBAP2 inhibited the migratory activity and promoted M2 polarization in macrophages, declining the productions of cytokines (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, and monocyte chemotactic protein [MCP]-1) and the PI3K/Akt/mTOR pathway. Yes In addition, circUBAP2 inhibited the migratory activity and promoted M2 polarization in macrophages, declining the productions of cytokines (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, and monocyte chemotactic protein [MCP]-1) and the PI3K/Akt/mTOR pathway. 35759302 TUSC7 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC patients Interaction(miR-1224-3p/ MAPK, PI3K/AKT, and NF-κB signaling pathways.) In Vivo Experiment//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Microarray//Cell Cycle Assay//Invasion Assay Low TUSC7 expression was found to be an independent prognostic factor of poor overall survival (OS) in TNBC patients. In terms of the mechanism, TUSC7 might perform its biological function through binding with miR-1224-3P and regulating its expression level. Besides, genes in cell cycle pathways, such as BUB3 (budding uninhibited by benzimidazoles 3) and TGF-ß (targeting transforming growth factor β) pathways were downregulated, and genes involved in the MAPK (mitogen-activated protein kinase) (TGFBR2, transforming growth factor-beta receptor 2), PI3K-AKT (phosphoinositide 3-kinase- AKT serine/threonine kinase 1) and NF-κB (nuclear factor-kappa B subunit) pathways were upregulated in TUSC7 knockdown MDA-MB-231 cells. Low TUSC7 expression was found to be an independent prognostic factor of poor overall survival (OS) in TNBC patients. Yes . Ectopic expression of TUSC7 inhibited tumor cell growth both in vitro and in vivo. 34305410 TUG1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction( TUG1/miR-593-3p/MAPK axis) qRT-PCR//Western Blot//Transwell Assay Here, we found that TUG1 was up-regulated in OSCC tissues and cell lines. We also validated that knockdown of TUG1 suppressed MAPK signaling pathway and inhibited EMT process in OSCC cells. Then, a novel LncRNA TUG1/ miR-593-3p/MAPK axis was verified to rescue cell viability in OSCC cells. Mechanistically, miR-593-3p bound to lncRNA TUG1, and lncRNA TUG1 positively regulated MAPK related proteins through acting as RNA sponger for miR-593-3p. Further gain- and loss-of-function experiments evidenced that the protective effects of lncRNA TUG1 knock-down on OSCC cells were abrogated by silencing miRNA-593-3p. Yes Silencing TUG1 suppressed proliferation migration, invasion and promoted apoptosis of OSCC cells. 35604743 TUG1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-216b-5p/DLX2 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay We found that there was a marked rise in TUG1 expression in HCC tissues and cells, and knockdown of TUG1 repressed the growth and metastasis and promoted apoptosis of HCC cells.TUG1 interacting with miR-216b-5p contributed to proliferation, metastasis, tumorigenesis and retarded apoptosis by activation of DLX2 in HCC. Yes We found that there was a marked rise in TUG1 expression in HCC tissues and cells, and knockdown of TUG1 repressed the growth and metastasis and promoted apoptosis of HCC cells. 31920462 hsa_circ_0074491 CircRNA Homo sapiens Cholesteatoma cholesteatoma tissues Interaction(miR-22-3p and miR-125a-5p/PI3K/Akt pathway) RNA Pull-Down//Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Invasion Assay We observed the downregulation of circ_0074491 in cholesteatoma tissues. Circ_0074491 was verified as a decoy for miR-22-3p and miR-125a-5p in cholesteatoma keratinocytes. Both miR-22-3p and miR-125a-5p silencing reversed the impacts of circ_0074491 silencing on proliferation, apoptosis, migration, and invasion of cholesteatoma keratinocytes. Also, circ_0074491 knockdown activated the PI3K/Akt pathway in cholesteatoma keratinocytes via miR-22-3p and miR-125a-5p. Yes Furthermore, circ_0074491 knockdown facilitated cell proliferation, migration, invasion, and repressed cell apoptosis in cholesteatoma keratinocytes. 34664835 TUG1 LncRNA Homo sapiens Carcinoma, Renal Cell Regulation[miR-299-3p/VEGF axis ] qRT-PCR These results indicate that sh-TUG1 inhibited renal cell carcinoma formation by miR-299-3p/VEGF axis in vitro and in vivo. Yes Furthermore, animal experiments have shown that sh-TUG1 inhibited tumor growth and metastasis and induces apoptosis in vivo. 31310753 hsa_circ_0008537 CircRNA Homo sapiens Liver Neoplasms liver cancer tissue specimens and cells Interaction(miR‑153‑3p/MCL1/Snail1) Western Blot//Bioinformatics Analysis//Wound Healing Assay//qRT-PCR//RIP//RNA-seq//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In the present study, circ_0008537 expression was associated with the GLI3 gene and was markedly increased in liver cancer tissue specimens and cells. circ_0008537 acted as a sponge of microRNA‑153‑3p (miR‑153‑3p), and a negative correlation was observed between circ_0008537 and miR‑153‑3p expression in liver cancer. In conclusion, the data indicated that circ_0008537 facilitated liver carcinogenesis by indirectly regulating miR‑153‑3p and leading to the release of MCL1 and Snail1. High expression levels of circ_0008537 exhibited a poor prognosis. Yes In addition, circ_0008537 overexpression resulted in an increased proliferation, migration and invasion of liver cancer cells, whereas circ_0008537 knockdown exhibited opposite effects. 33469676 circLRP6 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression(highly expressed) Western Blot//Transfection//qRT-PCR//Cell Proliferation Assay//Transwell Assay//IF The expression of circ-LRP6 in OSCC tissues was high. Yes Downregulation of circ-LRP6 reduced the EMT process of SCC-15 cells, as evidenced by increased E-cadherin and decreased vimentin and Zeb1 levels. Downregulation of circ-LRP6 also decreased autophagy as shown by increased levels of P62 and decreased LC3B in SCC-15 cells. 33501755 circSmoc1-2 CircRNA Homo sapiens Vascular Calcification VC Interaction(miR-874-3p/Adam19 axis ) In Vivo Experiment//Western Blot//ISH//Transfection//PCR//IHC Here, we investigated the function of circSmoc1-2, one of the circRNAs generated from the Smoc1 gene, which is downregulated in response to VC. . We went on to investigate the mechanism of circSmoc1-2 as a microRNA sponge and noted that miR-874-3p, the predicted target of circSmoc1-2, promotes VC, while overexpression of circSmoc1-2 reduces VC by suppressing miR-874-3p. Yes Inhibition of circSmoc1-2 worsens VC, while overexpression of circSmoc1-2 reduces VC, suggesting that circSmoc1-2 can prevent calcification. 35036071 TUG1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines interaction[TUG1/USF1/ROMO1 complex] Western Blot//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Transwell Assay UALCAN's gene expression dataset (ualcan.path.uab.edu) showed that the expression of USF1 in tumor tissues was significantly higher relative to normal tissues (Figure 3B). The expression of lncRNA TUG1 was then investigated by qRT‐PCR in six HCC cell lines, HepG2, SK‐HEP1, PLC / PRF5, SNU398, Hep3B, Huh7, and the non‐cancerous L02 (Figure 1F). The six HCC cell lines showed significantly higher lncRNA TUG1 expression compared with L02. The Huh7 cell line was used for further study as it was the cell type with the highest expression.The importance of the lncRNA TUG1/USF1/ROMO1 complex as a target for HCC therapy is a key result of this investigation which is exemplified by its role in regulating the proliferation, motility, and metastasis of HCC cells. Yes Enlisting the USF1 transcription factor to increase ROMO1 expression following upregulation of TUG1 lncRNA enhanced HCC Huh7 cell proliferation, motility, and metastasis. Rapid tumor proliferation in nude mice provided in vivo verification. 34766130 TUG1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-29c-3p/ COL1A1 Axis] Western Blot//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay Dramatically increased expression of TUG1 was noticed in HCC tissues and cell lines. TUG1 could promote the proliferation, migration and invasion of HCC cells through regulating miR-29c-3p/COL1A1 axis. Yes TUG1 knockdown restrained the proliferation, migration, and invasion, and promoted the apoptosis of HCC cells. 32821161 TUG1 LncRNA Homo sapiens Carcinoma, Hepatocellular hepatoma tissues and cells regulation[miR-137/AKT2 Axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay TUG1 was highly expressed in hepatoma tissues and cells.LncRNA TUG1 promotes hepatocellular carcinoma migration and invasion through targeting the miR-137/AKT2 axis. Yes Silencing TUG1 expression inhibited the viability, migration, and invasion of hepatoma cells. 32589479 TUG1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-421/KDM2A/ERK) CCK8//qRT-PCR//RNA Pull-Down//Transwell Assay The results demonstrated that TUG1 and SP1 were highly-expressed in CRC, wherein SP1 bound to the TUG1 promoter and consequently, positively regulated its expression. TUG1 could bind to miR-421 to increase KDM2A expression, a target gene of miR-421. TUG1 could activate the ERK pathway by impairing miR-421-targeted inhibition of KDM2A. Additionally, SP1 could facilitate the tumorigenesis of CRC cells in vivo by regulating the TUG1/miR-421/KDM2A/ERK axis. Yes Silencing of TUG1 caused suppression of CRC cell growth and promotion of cell apoptosis. 35508523 TUG1 LncRNA Homo sapiens Carcinoma, Hepatocellular L-O2 cells Interaction( miR-1-3p) qRT-PCR LncRNA TUG1 can adsorb miR-1-3p as a competitive endogenous RNA (ceRNA) to promote the expression of IGF1 and promote cell proliferation in hepatic carcinogenesis. Yes LncRNA TUG1 can adsorb miR-1-3p as a competitive endogenous RNA (ceRNA) to promote the expression of IGF1 and promote cell proliferation in hepatic carcinogenesis. 35421276 TUG1 LncRNA Homo sapiens Ovarian Neoplasms tumor tissue Expression[highly expressed] CCK8//qRT-PCR//Western Blot LncRNA TUG1 expression was higher in tumor tissue compared to paired adjacent tissue (P < .001), and it was positively correlated with pathological grade (P = .022), tumor size (P = .011) and FIGO stage (P < .001). LncRNA TUG1 expression was higher in tumor tissue compared to paired adjacent tissue (P < .001), and it was positively correlated with pathological grade (P = .022), tumor size (P = .011) and FIGO stage (P < .001). Yes In vitro, cells proliferation was promoted after treatment with lncRNA TUG1 mimic and was suppressed after treatment with lncRNA TUG1 inhibitor. 29742691 circNSUN2 CircRNA Homo sapiens Lymphoma malignant lymphoma tissues and cell lines Interaction(NRF1/HMGA1/ Wnt pathway) RNA Pull-Down//ChIP//Western Blot//Transfection//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay CircNSUN2 expression was abnormally high in malignant lymphoma tissues and cell lines. Bioinformatic analysis, DNA pull-down, ChIP and luciferase reporter experiments confirmed that circNSUN2 could be modulated by transcription factor NRF1. Through RT-qPCR, western blot and luciferase reporter assays, circNSUN2 was proved to influence Wnt pathway by modulating HMGA1. Yes CircNSUN2 inhibition could reduce proliferation and invasion of lymphoma. 33858292 TUG1 LncRNA Homo sapiens Ovarian Neoplasms OC cells Interaction(miR-582-3p) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Knockdown of miR-582-3p promoted the proliferation and migration of OC cells, while overexpression inhibited them. TUG1, a long non-coding RNA, was found to bind to miR-582-3p, and inhibition of lncRNA TUG1 decreased viability and migration and weakened the effect of miR-582-3p knockdown in OC cells. Yes Knockdown of miR-582-3p promoted the proliferation and migration of OC cells, while overexpression inhibited them. TUG1, a long non-coding RNA, was found to bind to miR-582-3p, and inhibition of lncRNA TUG1 decreased viability and migration and weakened the effect of miR-582-3p knockdown in OC cells. 34793263 hsa_circ_0023990 CircRNA Homo sapiens Thyroid Cancer, Papillary dedifferentiated TC tissues and cell lines Interaction(miR-485-5p/FOXM1 Axis) In Vivo Experiment//IHC//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay Hsa_circ_0023990 and FOXM1 were upregulated in dedifferentiated TC tissues and cell lines.. Mechanistically, miR-485-5p was demonstrated to interact with hsa_circ_0023990 and FOXM1 and involved in the regulation of has_circ_0023990 and FOXM1 in TC biological processes. Yes The higher level of hsa_circ_0023900 could stimulate the proliferation and glycolysis of dedifferentiated TC cells via positively regulating FOXM1. 34414414 hsa_circ_0025984 CircRNA Homo sapiens Ischemic Stroke brains of mice with MCAO Interaction(miR-143-3p/TET1/ORP150 Pathway) In Vivo Experiment//ChIP//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//H&E Staining//IF In astrocytes, OGD significantly decreased circ_0025984 and TET1 levels but increased miR-143-3p levels, which was also observed in brains of mice with MCAO. Our results demonstrated for the first time that circ_0025984 protects astrocytes from ischemia-induced autophagy and apoptosis by targeting the miR-143-3p/TET1 pathway and might inhibit cerebral injury induced by ischemic stroke. Furthermore, our data revealed the important positive regulation of ORP150 by TET1, which could be associated with its neuroprotective role. Yes Treatment with miR-143-3p inhibitor or circ_0025984 significantly decreased astrocyte apoptosis and autophagy, as well as cerebral injury and neuron loss in mice with MCAO. Notably, TET1 overexpression decreased astrocyte apoptosis and autophagy and induced promoter hypomethylation and expression of ORP150. 34435328 TUG1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC specimens and cell lines Interaction(miR-320a/FOXQ1 axis) CCK8//qRT-PCR TUG1 was significantly higher expression in BC specimens and cell lines. However, the function of miR-320a was opposite to that of TUG1, and miR-320a inhibitor partially eliminated the inhibitory effect of TUG1 knockdown on the malignant behavior of BC cells. As a microRNA sponge, TUG1 actively elevated FOXQ1 expression to sponge miR-320a and subsequently promoted BC cells malignant phenotypes. Yes TUG1 knockdown suppressed BC cells malignant behaviors in vitro and inhibited tumor growth and metastasis in vivo, while TUG1 overexpression promoted BC cells malignant behaviors in vitro. 34920123 TUG1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cell lines Interaction[sponging miR-524-5p] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Our results demonstrated a high expression of TUG1 in OSCC cells.These results indicated that TUG1 participated in the development of OSCC as a competing endogenous RNA to competitively bind to miR-524-5p and thus mediate DLX1 expression. Yes Overexpression of TUG1 markedly accelerated proliferative and migratory potentials of OSCC cells. 30980391 TUG1 LncRNA Homo sapiens Colonic Neoplasms cell lines Regulation[miR-26a-5p/MMP14/p38 MAPK/Hsp27 axis] Transwell Assay//qRT-PCR//IHC//Western Blot TUG1 expression was up-regulated in CaCO-2, SW620 and HT-29 cells, while miR-26a-5p was down-regulated.This study demonstrated that TUG1 accelerates the development of colon cancer by regulating miR-26a-5p/MMP14/p38 MAPK/Hsp27 axis in vitro and in vivo. Therefore, TUG1 provides a new direction for the treatment of Cc. Yes Functional analysis showed that sh-TUG1 significantly inhibited Cc cell proliferation, invasion and epithelial-mesenchymal transformation (EMT). 31697952 TUG1 LncRNA Homo sapiens Colorectal Neoplasms cancer stem cell Regulation(GATA6-BMP signaling pathway) RNA Pull-Down//Western Blot//Tunel//CCK8//qRT-PCR lncRNA TUG1 was elevated in CD133+/CD44+ cells with CSC characteristics. Mechanically, lncRNA TUG1 interacted with GATA6 and positively regulated its protein level and the rescue assays corroborated that lncRNA TUG1 knockdown repressed the characteristics and oxaliplatin resistance of CRC stem cells by decreasing GATA6 and functioned in CRC by targeting the GATA6-BMP signaling pathway. Yes Functionally, lncRNA TUG1 increased the characteristics and oxaliplatin resistance of CRC stem cells. 34858502 TUSC7 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues Interaction[downregulating hexokinase 2] CCK8//qRT-PCR//Western Blot It was observed that loc285194 was upregulated, while HK-2 mRNA was downregulated in patients with LSCC compared with healthy controls. Loc285194 overexpression significantly inhibited HK-2 expression and LSCC cell proliferation. HK-2 overexpression did not significantly affect Loc285194 expression, but promoted LSCC proliferation and attenuated the inhibitory effects of loc285194 overexpression on LSCC cell proliferation. lncRNA loc285194 may inhibit tumor growth of LSCC cells by downregulating HK-2. Yes Loc285194 overexpression significantly inhibited HK-2 expression and LSCC cell proliferation. 31555348 circSPG21 CircRNA Homo sapiens Intervertebral disc disease nucleus pulposus cells Interaction(miR-1197/ATP1B3) Western Blot//FISH//qRT-PCR//Bioinformatics Analysis//IF circSPG21 was found to play a role in human NPCs by acting as a sponge of miR-1197 and thereby affecting ATP1B3. Yes The expression of circSPG21 in the nucleus pulposus in IVDD was directly related to an imbalance of anabolic and catabolic factors, which affected cell senescence. 34611269 TUSC7 LncRNA Homo sapiens Pancreatic Carcinoma pancreatic carcinoma tissues,cell lines Interaction[modulating miR-371a-5p] qRT-PCR We found that TUSC7 was notably decreased in tissues and cell lines of pancreatic carcinoma. Further investigations demonstrated that miR-371a-5p directly bound with TUSC7 and negatively regulated by TUSC7. MiR-371a-5p rescued the inhibitory effects of TUSC7 on the development of pancreatic carcinoma. We conclude that lncRNA TUSC7 suppresses pancreatic carcinoma progression by modulating miR-371a-5p expression, indicating an innovative therapeutic strategy for pancreatic carcinoma. Moreover, the low expression of TUSC7 was correlated with advanced clinical grades and poorer overall survival. Yes Our findings revealed that TUSC7 repressed cell proliferation, migration, invasion, epithelial-mesenchymal transition, and stemness whereas facilitated cell apoptosis of pancreatic carcinoma cells. 30714151 TUSC7 LncRNA Homo sapiens stomach carcinoma GC tissues and cell lines regulation[Wnt/β-catenin signaling pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//EdU Staining//Transwell Assay Our data found that LOC285194 was lowly expressed both in human GC tissues and GC cell lines compared with corresponding normal controls.Mechanistically, silencing of LOC285194 promoted GC progression via inducing Wnt signaling activity. Moreover, in vivo xenografts nude mice model results showed that LOC285194 inhibited GC progression through targeting Wnt signaling. Yes Silencing of LOC285194 remarkably induced GC cell livability and cell proliferation. On the contrary, the LOC285194 overexpression suppressed MKN45 and HGC-27 cell proliferation and promoted cell apoptosis. Additionally, silencing of LOC285194 increased the ability of colony formation, cell migration, and invasive capacities, together with blocking the apoptotic rates of GC cells. 31991056 TUSC7 LncRNA Homo sapiens cervical squamous cell carcinoma blood Interaction[TGF-β1] qRT-PCR//ELISA Expression of lncRNA loc285194 was downregulated in HPV-positive and HPV-negative tissue samples and plasma from patients with CSCC and distinguished between patients and healthy controls. The expression of lncRNA loc285194 inhibited the migration of CSCC cells in vitro through the inactivation of TGF-ß1. Yes In SiHa and C33A cells, TGF-?1 expression was downregulated, and cell migration was inhibited following lncRNA loc285194 overexpression. 31774069 TUG38 LncRNA Homo sapiens Atherosclerosis serum Regulation[miRNA-21/PTEN axis] CCK8//qRT-PCR//Western Blot We found that the lncRNA TUG1 was highly expressed in serum samples from 38 patients with atherosclerosis, compared with 24 healthy volunteers. Yes Through loss- and gain-of function approaches, we showed that TUG1 promotes cell proliferation and induces apoptosis in vitro. 30468492 hsa_circ_0001874 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck saliva Interaction(hsa_circ_0001971/microRNA-186/SHP2 and hsa_circ_0001874/microRNA-297/PLK1) Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay it was identified that circ_0001847 and circ_0001971 respectively sponged the expression of miR-296 and miR-186 via binding to these miRNAs. Also, SHP2 mRNA and PLK1 mRNA were respectively targeted by miR-186 and miR-296-5p. We also established two signaling pathways, i.e., circ_0001971/miR-186/SHP2 and circ_0001874/miR-296-5p/PLK1, and validated the synergistic effect of circ_0001971 and circ_0001874 via observing their positive effect on cell proliferation and negative effect on cell apoptosis. The expression of miR-186 and miR-296-5p was generally lower in saliva of OSCC patients compared with that in OLK patients, while the expression of miR-186 and miR-296-5p was specifically up-regulated in saliva of OSCC patients. the finding of this study demonstrated that the relative level of hsa_circ_0001971 and hsa_circ_0001874 were different in the saliva of OSCC patients and could be used as predictive biomarkers for the development of OSCC. Yes By observing the effect of different miRNAs on the levels of circ_0001847 and circ_0001971, it was identified that circ_0001847 and circ_0001971 respectively sponged the expression of miR-296 and miR-186 via binding to these miRNAs. 34663837 circNRIP1 CircRNA Homo sapiens Keloid keloid tissue and keloid‑derived fibroblasts Interaction(miR‑503‑3p and miR‑503‑5p) RNA Pull-Down//Northern Blot//Western Blot//Transfection//Co-IP//Flow Cytometry//qRT-PCR//RIP//Cell Proliferation Assay//Colony Formation Assay circNRIP1 was highly expressed in keloid tissue and keloid‑derived fibroblasts. Functional analysis showed that circNRIP1 knockdown successfully blocked the proliferation and expression of extracellular matrix‑associated proteins while increasing the rate of apoptosis in keloid‑derived fibroblasts. Mechanistically, circNRIP1 maintained FXR1 stability by impeding Fbxo4‑mediated FXR1 ubiquitination and degradation. Additionally, FXR1 increased the abundance of miR‑503‑3p and miR‑503‑5p by contributing to pre‑miR‑503 maturation. Knockdown of FXR1, miR‑503‑3p and miR‑503‑5p also inhibited proliferation and extracellular matrix accumulation in keloid‑derived fibroblasts and increased levels of cell apoptosis. Collectively, the present study confirmed that circNRIP1 contributed to pre‑miR‑503 maturation via blocking Fbxo4‑mediated FXR1 ubiquitination and degradation, which facilitates keloid progression. Yes Knockdown of FXR1, miR‑503‑3p and miR‑503‑5p also inhibited proliferation and extracellular matrix accumulation in keloid‑derived fibroblasts and increased levels of cell apoptosis. 33649815 circPVT1 CircRNA Homo sapiens Precursor T-Cell Lymphoblastic Leukemia-Lymphoma bone marrows and cell lines of T-ALL Interaction(miR-30e/DLL4 pathway) Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay In this study, we found the expression levels of circPVT1 in bone marrows and cell lines of T-ALL were significantly up regulated and knock-down of circPVT1 in T-ALL cell lines could inhibit the cell proliferation and increase the cell apoptosis. Further analysis showed that circPVT1 could bind directly to miR-30e and contributed to the activate the Notch signaling by regulating miR-30e/DLL4 pathway. The levels of circPVT1 were obviously related to cumulative relapse rate and 5-year survival rate. In conclusion, our study reveals that circPVT1 participates in the progression of T-ALL through the miR-30e/DLL4 pathway and might represent a potential therapeutic target for T-ALL treatment. The levels of circPVT1 were obviously related to cumulative relapse rate and 5-year survival rate. Yes In this study, we found the expression levels of circPVT1 in bone marrows and cell lines of T-ALL were significantly up regulated and knock-down of circPVT1 in T-ALL cell lines could inhibit the cell proliferation and increase the cell apoptosis. 34237615 hsa_circ_0025908 CircRNA Homo sapiens Rheumatic Fever RA tissues Regulation(miR-137/HIPK2 axis) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Cell Proliferation Assay//ELISA//IHC The levels of circ_0025908 and HIPK2 were upregulated, and the miR-137 level was decreased in RA tissues in contrast to that in normal tissues. For functional analysis, circ_0025908 deficiency inhibited cell vitality, cell mitotic cycle, cell proliferation, and immunoreaction in RA cells, whereas promoted cell apoptosis. Moreover, miR-137 was confirmed to repress the progression of RA cells by suppressing HIPK2. In mechanism, circ_0025908 acted as a miR-137 sponge to regulate the level of HIPK2. Yes For functional analysis, circ_0025908 deficiency inhibited cell vitality, cell mitotic cycle, cell proliferation, and immunoreaction in RA cells, whereas promoted cell apoptosis. 34330307 TUG1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC PDX models Regulation IHC Comparative analysis indicated these established PDX models of NSCLC closely resembled the original tumors with regard to NSCLC subtype-specific markers TTF-1, napsin A, p63 and expression of LCAL6 and TUG1. The tumor volume and weight were significantly reduced in the TUG1-silenced group as compared to the control group (p<0.05). However, no significant tumor growth inhibition was found in the LCAL6-silenced group (p>0.05). Expression of both TUG1and LCAL6 was reduced by siRNA treatment. Expression of Ki67 and HOXB7 was significantly suppressed in both the TUG1- and LCAL6-silenced groups compared to the control group (p<0.01). The TUG1-silenced group showed more reduced Ki67 expression than the LCAL6-silenced group (p<0.05). Yes The tumor volume and weight were significantly reduced in the TUG1-silenced group as compared to the control group (p<0.05). 29277771 TUG1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction( miR-145-5p-TRPC6 pathway) CCK8//qRT-PCR//Western Blot Here, we measured the expression of TUG1 in clinical samples from CRC patients and found that the expression level of TUG1 was higher in CRC tissues compared with the normal adjacent tissues. Furthermore, we discovered that TUG1 affects the cellular processes in CRC cells by sponging miR-145-5p. We further found that miR-145-5p inhibits the expression of the protein-encoding gene Transient Receptor Potential Cation Channel Subfamily C Member 6 (TRPC6), and that overexpression of TRPC6 restored the inhibitory role of miR-145-5p in CRC cells. Yes We then performed knockdown of TUG1 with siRNAs in two CRC cell lines and found that TUG1 knockdown inhibited the viability, proliferation, and migration of CRC cells, and reduced the ability of CRC cells to form subcutaneous tumors. 32985219 TUG1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues,cell lines Regulation[miR-148a-3p/MCL-1/Wnt/β-catenin axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay The mRNA expression of TUG1 was significantly upregulated in ESCC tissues or cells, and was negatively correlated to miR-148a-3p expression in tissues.TUG1 regulated the biofunction and EMT progression of ESCC by mediating miR-148a-3p/MCL-1/Wnt/β-catenin axis in vitro. Yes Knockdown of TUG1 inhibited the proliferation, migration, and invasion, promoted apoptosis, and relieved the EMT progression in EC9706 and OE19 cells. 31742924 TUG1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells interaction[miR-498] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay TUG1 was upregulated in ESCC tissues and cells, and its high expression was associated with tumor lymph node metastasis and low cumulative survival.Furthermore, knockdown of TUG1 attenuated tumor growth in vivo. TUG1 accelerated tumorigenesis and metastasis by inducing XBP1 expression through directly targeting miR-498 in ESCC. TUG1 was upregulated in ESCC tissues and cells, and its high expression was associated with tumor lymph node metastasis and low cumulative survival. Yes TUG1 knockdown inhibited proliferation, migration, and invasion but promoted apoptosis in ESCC cells. 32305055 TUG1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells regulation[CDC42,miR-498] Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay TUG1 and CDC42 were upregulated while miR-498 was strikingly decreased in ESCC tissues and cells (P<0.0001). Inhibition of TUG1 hampered cell proliferation and invasion by downregulating CDC42 via upregulating miR-498 in ESCC cells. Yes Besides, TUG1 suppression blocked the proliferation and invasion of ESCC cells (P<0.001). 32139664 TUG1 LncRNA Homo sapiens Colorectal Neoplasms tissues from patients with CRC Regulation[Wnt/β-catenin pathway] qRT-PCR//MTT//Luciferase Report Assay//Western Blot Taken together, the data of the present study highlighted the pivotal role of the TUG1-Wnt/β-catenin signaling pathway in CRC, which could be targeted to improve the therapeutic efficacy of CRC. The results demonstrated that the expression of TUG1 was positively associated with the pathological grade and clinical stage of CRC patients. Yes Knockdown of TUG1 inhibited the proliferation of CRC cells and attenuated the activity of Wnt/β-catenin pathway in CRC cells. 30250601 circBUB1B_544aa CircRNA Homo sapiens Multiple Myeloma MM peripheral blood samples Expression(highly expressed) In Vivo Experiment//Transfection//Co-IP//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay//IF The circBUB1B_544aa elevated in MM peripheral blood samples was closely associated with MM poor outcomes and played a synergistic effect with BUB1B on evoking CIN. The circBUB1B_544aa elevated in MM peripheral blood samples was closely associated with MM poor outcomes and played a synergistic effect with BUB1B on evoking CIN. Yes In addition, MM cells could secrete circBUB1B_544aa and interfere the MM microenvironmental cells in the same manner as BUB1B full-length protein. Intriguingly, BUB1B siRNA, targeting the kinase catalytic center of both BUB1B and circBUB1B_544aa, significantly inhibited MM malignancy in vitro and in vivo. 34620840 TUG1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[TUG1/KLF4/miR-153-1 axis] ChIP//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Transwell Assay We demonstrated the over-expression of TUG1 and down-regulation of miR-153-1 in CRC. Our study unravels the critical involvement of TUG1/KLF4/miR-153-1 axis in CRC. Yes Knockdown of TUG1 or ectopic over-expression of miR-153-1 in SW480 significantly suppressed cell proliferation, migration and viability. 31576172 hsa_circ_0000296 CircRNA Homo sapiens Brain Ischemia HT22 cells and hippocampus treated with CCI Interaction(miR-194-5p/Runx3/Sirt1 axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//ChIP Here, we found that HT22 cells and hippocampus treated with CCI had low expression of circ_0000296, Runx3, Sirt1, but high expression of miR-194-5p. This study demonstrated that circ_0000296 specifically bound to miR-194-5p; miR-194-5p bound to the 3'UTR region of Runx3 mRNA; Runx3 directly bound to the promoter region of Sirt1, enhancing its transcriptional activity. Yes Overexpression of circ_0000296, Runx3, Sirt1, and silenced miR-194-5p significantly inhibited neuronal apoptosis induced by CCI. 34052838 WDFY3-AS2 LncRNA Homo sapiens Adenocarcinoma of Lung regulation[miR-491-5p/ZNF703 axis] RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay WDFY3-AS2 expression was elevated in LUAD and WDFY3-AS2 transcription was activated by transcription factor USF1. USF1-acitvated WDFY3-AS2 promotes LUAD progression via targeting miR-491-5p/ZNF703 axis, suggesting the potential value of WDFY3-AS2 as a novel target for LUAD treatment. Yes Silencing WDFY3-AS2 could suppress cell proliferation, migration, and invasion, whereas accelerate cell apoptosis in LUAD. 32275336 WDFY3-AS2 LncRNA Homo sapiens Esophageal Neoplasms EC specimens and cells Interaction(miR-18a/PTEN Axis) qRT-PCR//Western Blot Underexpression of WDFY3-AS2 was found in EC specimens and cells, which predicted a poor prognosis of EC patients. Additionally, WDFY3-AS2 was negatively correlated with miR-18a and positively with PTEN. Furthermore, we discovered that the expression of PTEN decreased by miR-18a mimic was rescued by WDFY3-AS2 overexpression. Underexpression of WDFY3-AS2 was found in EC specimens and cells, which predicted a poor prognosis of EC patients. Yes Reexpression of WDFY3-AS2 repressed the progression of EC via inhibiting cell proliferation, migration, and invasion. 34194502 WDFY3-AS2 LncRNA Homo sapiens Ovarian Neoplasms OC tissue and cells Regulation[WDFY3-AS2/miR-18a axis] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot WDFY3-AS2 and RORA were underexpressed in OC, while miR-18a was highly expressed. Notably, WDFY3-AS2 acts as a competing endogenous RNA to sponge miR-18a and upregulate RORA. Upon overexpressing WDFY3-AS2 or inhibiting miR-18a, RORA expression was increased, thereby the OC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) were suppressed, accompanied by enhanced apoptosis. Yes Upon overexpressing WDFY3-AS2 or inhibiting miR-18a, RORA expression was increased, thereby the OC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) were suppressed, accompanied by enhanced apoptosis.In vivo experiments confirmed that the tumor growth was reduced in response to overexpressed WDFY3-AS2 or inhibited miR-18a. 31347170 ZFAS1 LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[miR-150-5p/PLP2 axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down In this study, we found that the expression of ZFAS1 was upregulated in both glioma tissues and cell lines.By using online databases, RNA pull-down assays and luciferase reporter assays, ZFAS1 was demonstrated to act as a sponge of miR-150-5p. Furthermore, proteolipid protein 2 (PLP2) was shown to be the functional target of miR-150-5p. Rescue experiments revealed that ZFAS1 regulated the expression of PLP2 by sponging miR-150-5p. Finally, a xenograft tumor assay demonstrated that ZFAS1 promoted glioma growth in vivo. Our results showed that ZFAS1 promoted glioma malignant progression by regulating the miR-150-5p/PLP2 axis, which may provide a potential therapeutic target for the treatment of glioma. Yes Functional experiments revealed that ZFAS1 promoted glioma proliferation, migration and invasion, and increased resistance to temozolomide in vitro. 31535380 ZFAS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Expression[highly expressed] Western Blot//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//EdU Staining//Transwell Assay Overexpressed ZFAS1 and APEX1, and down-regulated miR-135a existed in OS tissues and cells. Yes Silenced ZFAS1 or elevated miR-135a inhibited colony formation and proliferation, cycle progression, migration and invasion while promoted apoptosis of MG63 cells. Silenced ZFAS1 or elevated miR-135a suppressed tumor volume and weight of OS in vivo. 31827400 ZFAS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma patient tissues and cell lines Interaction(SRSF3) CCK8//qRT-PCR//Western Blot This study discovered that ZFAS1 was upregulated in osteosarcoma patient tissues, which correlates with elevated SRSF3 protein levels. ZFAS1 knockdown decreased SRSF3 protein levels but had a negligible effect on SRSF3 mRNA expression. Further research indicated that ZFAS1 could bind to the SRSF3 protein directly and prevent degrading.Furthermore, exogenous SRSF3 expression in ZFAS1-depleted osteosarcoma cells restored SRSF3 expression while simultaneously inhibiting cell proliferation and metastasis. Higher levels of ZFAS1 or SRSF3 were linked to a poor prognosis of osteosarcoma. Yes Functional studies revealed that ZFAS1 knockdown inhibited osteosarcoma cell proliferation as measured by the CCK-8 assay, colony formation assay, and Ki-67 immunofluorescence staining. Furthermore, ZFAS1 knockdown reduced the expression of PCNA, CDK1, CDK4, and CDK6, increasing p53 and p16. IT has also been observed that ZFAS1 knockdown inhibited osteosarcoma cell migration and invasion as measured by the wound healing assay and the trans-well assay with or without Matrigel. 35184675 ZFAS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells Interaction(Lnc-ZFAS1/miR-520e/RHOC axes) RNA Pull-Down//Western Blot//Wound Healing Assay//FISH//RIP//IF//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay We found that LncRNA ZFAS1 was upregulated in osteosarcoma, and Lnc-ZFAS1 overexpression facilitated osteosarcoma cells proliferation, migration, invasion and EMT, while Lnc-ZFAS1 silence exerted reverse influence. Mechanistically, Lnc-ZFAS1 functionally acted as a sponger of microRNA-520b (miR-520b) and microRNA-520e (miR-520e) to up-regulate Ras Homologue C (RHOC). In addition, depleted Lnc-ZFAS1 restrained osteosarcoma cells proliferation, migration, and invasion, which could be rescued by RHOC overexpression. Yes We found that LncRNA ZFAS1 was upregulated in osteosarcoma, and Lnc-ZFAS1 overexpression facilitated osteosarcoma cells proliferation, migration, invasion and EMT, while Lnc-ZFAS1 silence exerted reverse influence. Lnc-ZFAS1 was upregulated in osteosarcoma and Lnc-ZFAS1 could exert promoted impact upon osteosarcoma cells proliferation, migration, invasion, and EMT in vitro. 36473367 ZFAS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow,cell lines Regulation[microRNA-150/Sp1 and microRNA-150/Myb pathways] qRT-PCR In the present study, RT-qPCR assay showed that ZFAS1 was highly expressed in bone marrow of acute leukemia patients and AML cell lines. In summary, our data demonstrated that ZFAS1 knockdown hampered AML progression by regulating miR-150/Myb and miR-150/Sp1 pathways, providing some potential biomarkers or targets for the diagnosis and treatment of leukemia. Yes Loss-of-function analyses revealed that ZFAS1 knockdown inhibited proliferation and promoted apoptosis in AML cells and curbed AML xenograft growth in vivo. 30502345 ZFAS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Expression[highly expressed] Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Transwell Assay ZFAS1 was significantly upregulated in cervical cancer tissues and cell lines, and increased ZFAS1 levels led to poor prognoses in patients. Yes In addition, cells in the siR-ZFAS1 group showed remarkably reduced ZFAS1 expression as well as cell proliferation, invasion and migration. 30738960 ZFAS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Expression[highly expressed] RNA Pull-Down//MeRIP//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that ZFAS1 was significantly upregulated in CC tissues. Elevation of ZFAS1 correlated with advanced FIGO stage, lymph node and distant metastasis, and also indicated poor overall survival in patients with CC. Yes Functional experiments demonstrated that ZFAS1 promoted CC cell proliferation, migration and invasion in vitro, and facilitated tumor growth and metastasis in vivo. 33235466 ZFAS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tumor tissues Interaction(miR-190a-3p/KLF6 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The expression levels of ZFAS1 and KLF6 were both significantly elevated, while the expression of miR-190a-3p was inhibited in CC tumor tissues. In addition, ZFAS1 influenced CC tumor growth through miR-190a-3p. KLF6 was a target of miR-190a-3p and inhibited miR-190a-3p-induced CC tumor growth. Furthermore, KLF6 was negatively regulated by miR-190a-3p, but positively regulated by ZFAS1. Yes Finally, in vitro assays demonstrated that inhibition of ZFAS1 reduced CC tumor growth and the expression levels of KLF6, but increased the expression levels of miR-190a-3p. 35112985 ZFAS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms blood samples of TNBC patients (n=40)and matched healthy controls (n=40). Interaction(STAT3) Migration Assay//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay Here, we found that the expression of the lncRNA, ZFAS1, was significantly downregulated (∼3.0-fold) in blood samples of TNBC patients (n=40) compared to matched healthy controls (n=40). we identified a strong negative correlation between ZFAS1 and signal transducer and activator of transcription 3 (STAT3) gene expression (R = -0.11, p-value = 0.0002). Further, we observed that decreased ZFAS1 expression significantly (p < 0.05) increased STAT3 and phosphorylated STAT3 (at Ser727 residue) protein levels in TNBC cells. Yes Functionally, silencing of ZFAS1 promoted cell proliferation and colonization of human MDA-MB-231 TNBC cells by inhibiting the expression levels of the cyclin-dependent kinase (CDK) inhibitors p21 (CDKN1A) and p27 (CDKN1B) compared to the scrambled siRNA control cells. Further, we found that downregulation of ZFAS1 led to decreased protein levels of the epithelial markers, E-cadherin, Claudin-1, and Zo-1, with increased protein levels of the mesenchymal markers, Slug and ZEB1. 33429003 ZFAS1 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-1271-5p/HK2 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay ZFAS1 was highly expressed in glioma tissues and cells, ZFAS1 was involved in proliferation, migration, and apoptosis of glioma cells via regulating miR-1271-5p/HK2 axis. ZFAS1 was highly expressed in glioma tissues and cells, besides, the expression level of ZFAS1 was associated with survival time of glioma patients. Yes Functional experiments suggested that knockdown of ZFAS1 or upregulation of miR-1271-5p constrained proliferation, migration and induced apoptosis of glioma cells. Besides, deficiency of ZFAS1 hindered tumor growth in vivo. 32964288 ZFAS1 LncRNA Homo sapiens Endometrial Neoplasms EC patients Expression [highly expressed] qRT-PCR//Wound Healing Assay//Western Blot Here, we found ZFAS1 expression was significantly upregulated in EC patients, which was significantly associated with International Federation of Gynecology and Obstetrics stage, histological grade, myometrial invasion and poor prognosis. Moreover, knockdown of ZFAS1 obviously downregulated the expression of CDK4, Cyclin D1 and N-cadherin, but upregulated E-cadherin expression. Yes The loss-of-function assays showed that knockdown of ZFAS1 significantly suppressed the proliferation, G1/S transition, migration and invasion in EC cells. 33151128 ZFAS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues,cell lines Interaction[sponging miR-135a ] Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay "Our data showed the expression of ZFAS1 was up-regulated and miR-135a was down-regulated in NPC tissues and cells. Besides, down-regulation of miR-135a reversed abrogation of ZFAS1-mediated inhibition of proliferation, migration and invasion and increase of apoptosis in NPC cells. Our data suggested Inhibition of ZFAS1 protected against proliferation, migration and invasion but contributed to apoptosis by sponging miR-135a in NPC cells, providing a novel avenue for NPC treatment. " Yes Moreover, knockdown of ZFAS1 or addition of miR-135a inhibited cell proliferation, migration and invasion but promoted apoptosis in NPC cells. 31307201 ZFAS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction[PI3K/AKT pathway] qRT-PCR//MTT//Western Blot ZFAS1 was significantly upregulated in NPC tissues and cell lines. Moreover, 740Y-P could rescue the effects of ZFAS1 knockdown on proliferation, apoptosis and invasion in 5-8F cells. Yes Silencing ZFAS1 significantly inhibited cell proliferation and invasion, arrested cell cycle progression and promoted cell apoptosis, as well as reduced epithelial-mesenchymal transition. 31403940 ZFAS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Interaction[sponging miR-892b ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of multiple lncRNAs, of which ZFAS1 was up-regulated, was dysregulated in NPC tissues.ZFAS1 directly targeted miR-892b, and miR-892b negatively regulated the expression of downstream LPAR1. Yes The proliferation, migration and invasion of NPC cells could be largely enhanced by the downregulation of miR-892b as well as the up-regulation of ZFAS1 and LPAR1, In nude mice, the growth of tumour xenografts formed by HONE1 cells was significantly suppressed when ZFAS1 was silenced. 31851778 hsa_circ_000166 CircRNA Mus musculus Diabetic Renal Fibrosis kidney tissues of DN renal fibrosis mice Interaction(miR-296/SGLT2) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay Compared with that of normal controls, the expression of circ_000166 in the kidney tissues of DN renal fibrosis mice substantially increased. Moreover, circ_000166 could act as the ceRNA of miR-296 and competitively bind to miR-296, leading to an increase in the expression of the SGLT2 gene regulated by miR-296. Through mutual verification via in vivo and in vitro experiments, miR-296 was overexpressed and SGLT2 was silenced. Yes Silencing circ_000166 could minimize kidney damage and decrease urine protein levels, thereby inhibiting the progression of renal fibrosis. 35615399 ZFAS1 LncRNA Homo sapiens Nasopharyngeal carcinoma tumor tissues and NPC cells Interaction(miR-100-3p/ATG10/PI3K/AKT pathway) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//H&E Staining//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Microarray//IHC//IF ZFAS1 is upregulated in tumor tissues and NPC cells. N (6)-methyladenosine (m6A) is highly enriched in ZFAS1 and enhances its RNA stability. ZFAS1 is used as an oncogenic lncRNA, which can promote NPC cell proliferation, migration and tumor growth. In terms of mechanism, ZFAS1 up-regulates the expression of ATG10 by competitively adsorbing miR-100-3p and regulates the level of autophagy by inhibiting the PI3K/Akt signaling pathway to promote the proliferation and migration of NPC cells. Yes ZFAS1 is used as an oncogenic lncRNA, which can promote NPC cell proliferation, migration and tumor growth. 34980191 ZFAS1 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer cells Interaction(miR-497-5p/HMGA2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//IHC We also demonstrated that ZFAS1 exerts its effects by promoting HMGA2 expression through decoying miR-497-5p. We also found that ZFAS1 promoted the progression of pancreatic cancer in vivo by modulating the miR-497-5p/HMGA2 axis. Yes ZFAS1 promoted the growth and metastasis of pancreatic cancer cells, and miR-497-5p acted as a tumour suppressor gene in pancreatic cancer by targeting HMGA2. 34552050 ZFAS1 LncRNA Homo sapiens Adenocarcinoma of Lung LAD tissues and cells regulation[miR-1271-5p,FRS2] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Upregulation of lncRNA ZFAS1 was found in LAD tissues and cells. LncRNA ZFAS1 promotes cell proliferation, migration and invasion in LAD by downregulating miR-1271-5p or upregulating FRS2. Yes Knockdown of lncRNA ZFAS1 restrained cell proliferation, migration and invasion in LAD cells. 32515146 ZFAS1 LncRNA Homo sapiens Cholangiocarcinoma cholangiocarcinoma tissues Interaction[modulating USF1 via miR-296-5p] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot LncRNA ZFAS1 expression was relatively up-regulated in tumour tissues and cells while miR-296-5p was significantly down-regulated.LncRNA ZFAS1 expression was relatively up-regulated in tumour tissues and cells while miR-296-5p was significantly down-regulated. Knockdown of ZFAS1 significantly suppressed tumour proliferation, migration, invasion and USF1 expression. Overexpressed miR-296-5p suppressed cell proliferation and metastasis. Knockdown of USF1 inhibited cell proliferation and metastasis and xenograft tumour growth. In conclusion, ZFAS1 might promote cholangiocarcinoma proliferation and metastasis by modulating USF1 via miR-296-5p. Yes Knockdown of ZFAS1 significantly suppressed tumour proliferation, migration, invasion and USF1 expression. 31565837 circITGB1 CircRNA Mus musculus Cardiac Inflammation mouse AMI model Interaction(miR-342-3p/NFAM1) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//FISH//Luciferase Report Assay//H&E Staining In this study, circITGB1 (has_circRNA_0018146), derived from exon 1 of the ITGB1 gene localized on chromosome 10, was shown to be considerably increased in plasma from patients with AMI compared to healthy controls, as demonstrated by the comparison of EV-circRNA expression patterns. Using a luciferase screening assay and a biotin-labeled circITGB1 probe to identify microRNA(s) complementary to circITGB1 sequences, we discovered that circITGB1 competitively binds to miR-342-3p and inhibits its expression, which in turn increase the expression of NFAT activating molecule 1 (NFAM1). Based on western blotting and immunological studies, circITGB1 controls dendritic cell maturation by targeting miR-342-3p and NFAM1. Yes circITGB1 also exacerbated cardiac damage and regulated miR-342-3p and NFAM1 expression in a mouse AMI model. 35615580 ZFAS1 LncRNA Homo sapiens Prostatic Neoplasms PCa cells and tissues interaction[Binding to miR-135a-5p] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay ZFAS1 expression was up-regulated in PCa cells and tissues. Knocking down ZFAS1 could inhibit the proliferation, invasion and metastasis of PCa cells through regulating miR-135a-5p expression. Yes ZFAS1 could competitively bind to miR-135a-5p in PCa cells, and down-regulation of ZFAS1 inhibited cell viability, proliferation, migration, invasion of PCa cells and the occurrence of epithelial-mesenchymal transformation (EMT) and promoted apoptosis of PCa cells and increased the miR-135a-5p expression. 32104094 hsa_circ_0005379 CircRNA Rattus norvegicus Squamous Cell Carcinoma of Head and Neck OSCC tissues and SCC15 cell lines Interaction(miR-17-5p/acyl-CoA oxidase 1 axis) qRT-PCR//MTT Compared with adjacent cancer tissues, the expression levels of circ_0005379 and ACOX1 proteins in OSCC tissues were decreased (P<0.05), and the expression level of miR-17-5p was increased (P<0.05). Compared with HOK-16A cells, the expression levels of circ_0005379 and ACOX1 proteins in SCC15 cell lines were decreased (P<0.05), and the expression level of miR-17-5p was increased (P<0.05). After overexpressing circ_0005379, the activity and number of migrating and invading SCC15 cells and the expression levels of β-catenin and Snail proteins were decreased (P<0.05); however, the apoptosis rate and expression level of E-cadherin protein were increased (P<0.05). In SCC15 cells, circ_0005379 targeted the negative regulation of miR-17-5p expression, and miR-17-5p targeted the negative regulation of ACOX1 expression. Overexpressing miR-17-5p or silencing ACOX1 could reverse the effects of circ_0005379 overexpression on the proliferation, apoptosis, migration, and invasion of OSCC cell lines. The tumor volume and weight of nude mice overexpressing circ_0005379 were decreased (P<0.05), the expression levels of circ_0005379 and ACOX1 protein in tumor tissues were increased (P<0.05), and the expression level of miR-17-5p was decreased (P<0.05). Yes After overexpressing circ_0005379, the activity and number of migrating and invading SCC15 cells and the expression levels of β-catenin and Snail proteins were decreased (P<0.05); however, the apoptosis rate and expression level of E-cadherin protein were increased (P<0.05). In SCC15 cells, circ_0005379 targeted the negative regulation of miR-17-5p expression, and miR-17-5p targeted the negative regulation of ACOX1 expression.The tumor volume and weight of nude mice overexpressing circ_0005379 were decreased (P<0.05), the expression levels of circ_0005379 and ACOX1 protein in tumor tissues were increased (P<0.05), and the expression level of miR-17-5p was decreased (P<0.05). 34409798 hsa_circ_0023028 CircRNA Rattus norvegicus Squamous Cell Carcinoma of Head and Neck LSCC tissues and cells Interaction(miR-486-3p/lasp1) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay High expression of circ_0023028 was observed in LSCC tissues and cells. Circ_0023028 was stable and possessed a loop structure. Circ_0023028 silencing suppressed LSCC cell proliferation, metastasis and cell cycle process and induced apoptosis in vitro and hampered tumor growth in vivo. Further mechanism analysis demonstrated that circ_0023028 could sponge miR-486-3p to regulate LASP1 expression in LSCC cells. The malignant behaviors of LSCC cells mediated by circ_0023028 knockdown were rescued by the inhibition of miR-486-3p. Moreover, miR-486-3p suppressed LSCC cell progression via binding to LASP1. Circ_0023028 knockdown might impede the progression of LSCC by regulating miR-486-3p/LASP1 axis, which could provide a novel insight on the mechanism of LSCC progression. Yes Circ_0023028 silencing suppressed LSCC cell proliferation, metastasis and cell cycle process and induced apoptosis in vitro and hampered tumor growth in vivo. 33755879 hsa_circ_0058058 CircRNA Rattus norvegicus Multiple Myeloma MM cells Interaction(miR-338-3p/ATG14 pathway) In Vivo Experiment//Western Blot//Transfection//Tube Formation Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ_0058058 was up-regulated in MM bone marrow aspirates and cells, knockdown of circ_0058058 reduced MM cell proliferation, angiogenesis and metastasis, but induced apoptosis in vitro. In a MM xenograft mouse model, circ_0058058 silencing reduced MM tumor growth and cell proliferation. Mechanistically, circ_0058058 acted as a sponge for miR-338-3p to up-regulate ATG14 expression, which was validated to be a target of miR-338-3p. Rescue assay showed that miR-338-3p inhibition reversed the antitumor effects of circ_0058058 knockdown on MM cell. Moreover, forced expression of miR-338-3p suppressed MM cell malignant phenotype, which was abolished by ATG14 up-regulation. Yes knockdown of circ_0058058 reduced MM cell proliferation, angiogenesis and metastasis, but induced apoptosis in vitro. In a MM xenograft mouse model, circ_0058058 silencing reduced MM tumor growth and cell proliferation. Mechanistically, circ_0058058 acted as a sponge for miR-338-3p to up-regulate ATG14 expression, which was validated to be a target of miR-338-3p. 34930344 ZFAS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissue and cell Regulation( LIN28 and CAPRIN1) Migration Assay//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay The plasma level of lncRNA ZFAS1 was significantly higher in preoperative patients with gastric cancer than in individuals in the other 4 groups. LIN28 and CAPRIN1 were identified as key downstream mediators of ZFAS1 in gastric cancer cells. Increased expression of ZFAS1 was significantly associated with lymph node metastasis, advanced TNM stage, and poor prognosis. Yes ZFAS1 regulated the proliferation, migration, and invasion of gastric cancer cells and regulated the growth of gastric cancer cells in vivo. 36160641 ZFAS1 LncRNA Homo sapiens Breast Neoplasms BC cells regulation[PTEN/PI3K/AKT signal pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay As a result, ZFAS1 expression was increased and miR-589 expression was decreased in BC cells.In conclusion, this study indicated that ZFAS1 inhibited the proliferation, invasion and migration of breast cancer cells by targeting miR-589 through regulating the PTEN/PI3K/AKT signal pathway. Yes ZFAS1 overexpression could inhibit the proliferation, colony formation, invasion and migration of BC cells while miR-589 overexpression could reverse the changes. 32189153 ZFAS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Regulation[miR-150-5p/HMGA2 signaling] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Experimental assays revealed that clinical samples and cell lines of lung malignant tumors showed an upregulation of ZFSA1.To summarize, we, for the first time, demonstrated the inhibitory effects of ZFAS1 knockdown on NSCLC cell progression, and the results from mechanistic studies indicated that ZFAS1-mediated NSCLC progression cells via targeting miR-150-5p/HMGA2 signaling. Yes The loss-of-function assays showed that knockdown of ZFAS1-suppressed NSCLC cell proliferative, as well as invasive potentials, increased NSCLC cell apoptotic rates in vitro and also attenuated tumor growth of NSCLC cells in the nude mice. 31692094 ZFAS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Regulation[microRNA-124/STAT3 axis] RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//FISH//RIP//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay LncRNA ZFAS1 was upregulated and miR-124 was down-regulated in ESCC tissues.LncRNA ZFAS1 was considered to be a competing endogenous RNA to regulate miR-124, thereby elevating STAT3 expression. Exosomes shuttled ZFAS1 stimulated proliferation, migration and invasion of ESCC cells and restricted their apoptosis with increased STAT3 and declined miR-124. Furthermore, in vivo experiment suggested that elevated ZFAS1-exo promoted tumor growth in nude mice. Yes Silencing of ZFAS1 contributed to suppressed proliferation, migration, invasion and tumor growth in vitro and induced apoptosis of ESCC cells. 31775815 ZFAS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and adjacent normal tissues Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray//Transwell Assay We found that lncRNA ZNFX1-AS1 is significantly upregulated in CRC, and the newly identified lncRNA ZNFX1-AS1-miR-144-EZH2 axis is involved in the regulation of CRC progression, which might be used as potential therapeutic targets for CRC patients. We found that lncRNA ZNFX -AS expression was significantly upregulated in CRC tissues and cell lines, and the expression of lncRNA ZNFX -AS was associated with aggressive tumor phenotype and poor prognosis in CRC. Yes Functionally, knockdown of lncRNA ZNFX1-AS1 inhibited cell proliferation, invasion, in vitro and tumorigenesis and metastasis in vivo. 30770796 circARHGAP12 CircRNA Rattus norvegicus Atherosclerosis MASMCs Interaction(miR-630/EZH2/TIMP2 signal axis) RNA Pull-Down//Transfection//qRT-PCR//Luciferase Report Assay//H&E Staining Compared with the normal group, the expression of circARHGAP12 in the MASMCs under ox-LDL treatment was elevated, and circARHGAP12 silencing could inhibit AS in vitro and in vivo. The results of the mechanism study showed that circARHGAP12 can directly bind with miR-630. In addition, miR-630 can also target EZH2 to modulate the transcription of TIMP2 and to influence the migration of MASMCs. circARHGAP12 is upregulated in AS. CircARHGAP12 knockdown can inhibit the progression of AS. Yes circARHGAP12 silencing could inhibit AS in vitro and in vivo; 34750830 ZFAS1 LncRNA Homo sapiens Colorectal Neoplasms CRC cells and tissues regulation[DDX21-POLR1B regulatory axis] RNA Pull-Down//Western Blot//qRT-PCR//Transwell Assay//IF Specifically, ZFAS1 exerted its oncogenic functions and was significantly up-regulated accompanied by elevated DDX21, POLR1B expression in CRC cells and tissues, which further closely associated with poor clinical outcomes. The unrecognized ZFAS1/DDX21/POLR1B signaling regulation axis may provide new biomarkers and targets for CRC treatment and prognostic evaluation. Specifically, ZFAS1 exerted its oncogenic functions and was significantly up-regulated accompanied by elevated DDX21, POLR1B expression in CRC cells and tissues, which further closely associated with poor clinical outcomes. Yes Notably, ZFAS1 knockdown dramatically suppressed CRC cell proliferation, invasion, migration, and increased cell apoptosis, which were contrary to the effect caused by ZFAS1 up-regulation. 33202381 ZFAS1 LncRNA Homo sapiens pancreatic adenocarcinoma regulation[RHOA/ROCK2 pathway,miR-3924] ISH//qRT-PCR//Luciferase Report Assay ZFAS1 overexpression in pancreatic adenocarcinoma was predicted and experimentally verified. Dual-luciferase reporter assays were used to confirm the binding of ZFAS1/miR-3924 and miR-3924/ROCK2, and rescue assays were performed to further investigate the underlying mechanism. Yes ZFAS1 silencing inhibited pancreatic adenocarcinoma metastasis in vitro and in vivo. 32550827 hsa_circ_0007142 CircRNA Rattus norvegicus Colorectal Neoplasms CRC cells Interaction(circ_0007142/miR-874-3p/GDPD5 axis) qRT-PCR//Luciferase Report Assay//Western Blot Circ_0007142 was overexpressed in CRC. After expression inhibition of circ_0007142, proliferation was reduced, while apoptosis and ferroptosis were facilitated in CRC cells. Mechanically, circ_0007142 was found as a miR-874-3p sponge and miR-874-3p inhibitor eliminated the regulation of si-circ_0007142 in CRC cells. MiR-874-3p targeted GDPD5 and upregulation of GDPD5 reversed the miR-874-3p-triggered tumour inhibition and ferroptosis promotion in CRC cells. Moreover, GDPD5 was regulated by the circ_0007142/miR-874-3p axis. Circ_0007142 also affected CRC tumorigenesis in vivo through the regulation of miR-874-3p and GDPD5. Yes After expression inhibition of circ_0007142, proliferation was reduced, while apoptosis and ferroptosis were facilitated in CRC cells. 33797091 ZFAS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(PABP2 / SREBP1) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP We analyzed three independent microarray datasets of CRC tissues from GEO and found that ZFAS1 expression was remarkably upregulated in all three datasets. Mechanistically, ZFAS1 binds polyadenylate-binding protein 2 (PABP2) to stabilize SREBP1 mRNA, thereby increasing the expression of SREBP1 and its target genes stearoyl-CoA desaturase (SCD1) and fatty acid synthase (FASN), thus promoting CRC lipid accumulation. Moreover, we validated the overexpression of ZFAS1 in CRC tissues compared with normal tissues and found that ZFAS1 was positively correlated with tumor size and metastasis in CRC. Yes Knockdown of ZFAS1 significantly suppressed the malignant phenotype and lipogenesis of CRC cells. 35036050 ZFAS1 LncRNA Homo sapiens Colorectal Neoplasms CRC samples Interaction(miR-34b/SOX4 Targeting) qRT-PCR//Luciferase Report Assay//RIP//Western Blot In the present study, the long noncoding RNA zinc finger antisense 1 (ZFAS1) was proved to have high expression level in CRC samples and in advanced stages. Our data demonstrated the functions and mechanisms of ZFAS1 in CRC metastasis, illustrating miR-34b directly targets ZFAS1 and inhibits metastasis ability of CRC cells. SOX4 is also the direct downstream target of miR-34b, and silencing ZFAS1 can inhibit SOX4 though modulating miR-34b. Yes Silencing ZFAS1 reduced both migration and invasion ability of DLD-1 and HCT-116 cells, which is relevant to the EMT process. 33725330 ZFAS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues,cell lines (B-CPAP, IHH-4, TPC-1, and K-1) Interaction[sponging miR-590-3p] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay We found that the expression of ZFAS1 was increased in PTC tissues and four PTC cell lines (B-CPAP, IHH-4, TPC-1, and K-1).Bioinformatics analysis revealed that miR-590-3p targeted the 3'-UTR of ZFAS1. The double luciferase reporter and RNA-binding protein immunoprecipitation assay demonstrated that miR-590-3p is a target of ZFAS1. Rescue experiments confirmed that miR-590-3p could reverse the effect of ZFAS1 on PTC cells. Moreover, we identified high mobility group AT-hook 2 (HMGA2) to be a downstream target of miR-590-3p and ZFAS1 which activates HMGA2 expression by sponging to miR-590-3p. Yes The gain- and loss-of-function assays showed that overexpressing ZFAS1 promoted cell proliferation and inhibited cell apoptosis in PTC cells in vitro. We demonstrated that knockdown of ZFAS1 inhibits tumor growth and upregulation of ZFAS1 promotes tumor growth in vivo. 31571903 ZFAS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[repressing miR-193a-3p] CCK8//qRT-PCR//Colony Formation Assay//EdU Staining ZFAS1 was significantly highly expressed in HCC tissues than that of adjacent normal tissues.ZFAS1 could enhance the proliferation of HCC cells by suppressing miR-193a-3p, which might be a potential therapeutic target in HCC. Yes The growth ability of HCC cells was markedly inhibited after ZFAS1 was silenced. However, the growth ability of HCC cells was remarkably promoted after ZFAS1 overexpression. 31799651 ZFAS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[microRNA-624/MDK/ERK/JNK/P38 Signaling Pathway] qRT-PCR ZFAS1 was overexpressed in HCC tissues and cells and indicated worse prognosis and shorter survival in patients with HCC.Collectively, ZFAS1 depletion inhibited the occurrence of HCC by downregulating the MDK/ERK/JNK/P38 pathway through restoring miR-624 expression. Inhibition of ZFAS1 may act as an innovative target to suppress occurrence in HCC. ZFAS1 was overexpressed in HCC tissues and cells and indicated worse prognosis and shorter survival in patients with HCC. Yes Silencing of ZFAS1 inhibited the malignancy of HCC cells, but miR-624 inhibitor could partially reverse the repressive role of si-ZFAS1. 32547074 ZFAS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tumor tissues and cell lines regulation[miR-193a-3p/SDC1 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay ZNFX1-AS1 was over-expressed in bladder cancer tumor tissues and cell lines. ZNFX1-AS1 regulated bladder cancer progression by targeting the miR-193a-3p/SDC1 axis. ZNFX1-AS1 expression was found to be associated with tumor size and advanced clinical stage in patients with bladder cancer. Yes Downregulation of ZNFX1-AS1 inhibited cell proliferation, cell clone formation, migration, and invasion of bladder cancer cells. 32432735 ZFAS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells and tissues Interaction(miR-6499-3p/CCL5 Axis) qRT-PCR//Western Blot Firstly, we found lncRNA ZFAS1 expression increased within OSCC cells and tissues and was positively associated with tumor progression. Secondly, its lncRNA-miRNA-mRNA network was determined, and the target of ZFAS1 was identified as miR-6499-3p/C-C motif chemokine ligand 5 (CCL5). Mechanistically, we found that ZFAS1 up-regulated CCL5 by competitively sponging miR-6499-3p. Yes Further studies demonstrated that ZFAS1 promoted tumor progression in vivo and in vitro. 34697152 ZFAS1 LncRNA Homo sapiens Prostatic Neoplasms prostate tissues Interaction[c-Myc] Western Blot//ISH//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//Transwell Assay In the present study, we discovered that ZFAS1 is upregulated in PCa and that ZFAS1 overexpression predicted poor clinical outcomes. Taken together, we suggest a regulatory network in which ZFAS1 is capable of enhancing c-Myc expression by inducing the expression of YAP1, TEAD1, and KDM3A through crosstalk with their upstream miRNAs, thereby globally promoting prostate cancer tumorigenesis. In the present study, we discovered that ZFAS1 is upregulated in PCa and that ZFAS1 overexpression predicted poor clinical outcomes. Yes ZFAS1 overexpression notably promoted the proliferation, invasion, and epithelial-mesenchymal transition of PCa cells. 31321444 ZFAS1 LncRNA Homo sapiens Thyroid Neoplasms thyroid carcinoma tissues regulation[miR-302-3p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results demonstrated that lncRNA ZFAS1 expression was upregulated in thyroid carcinoma tissues, TT and SW579 cells, and was associated with the proliferation of these two cell lines. In addition, the downregulation of ZFAS1 not only reversed the promotive effects of miR‑302a‑3p inhibitor on CCND1 expression and the epithelial‑mesenchymal transition (EMT) of TT and SW579 cells, but also targeted and increased the expression of miR‑302a‑3p, and further reduced the expression of CCND1, resulting in suppression of the proliferation, migration, invasion and EMT of thyroid carcinoma cells. Yes Notably, downregulation ZFAS1 reduced migration and invasion, and reversed the promotive effects of miR?302a?3p inhibitor on the proliferation, migration and invasion of TT and SW579 cells. 33179076 hsa_circ_0067835 CircRNA Rattus norvegicus Rhinitis, Allergic nasal mucosa tissues of AR mice Interaction(miR-155/GATA3) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//ELISA Circ_0067835 expression levels were raised in the nasal mucosa tissues of AR mice. Inhibiting circ_0067835 could reduce Type2 cytokines and ILC2s levels in AR mice model. Furthermore, circ_0067835 targeted and positively regulated miR-155 expression, and GATA3 was a downstream target of miR-155 and adjusted by circ_0067835/miR-155 axis. In addition, silencing circ_0067835 inhibited cytokines and ILC2s levels by down-regulating miR-155. Circ_0067835 effectively inhibited AR response in ILC2s through participation of miR-155/GATA3 axis. Yes Inhibiting circ_0067835 could reduce Type2 cytokines and ILC2s levels in AR mice model.In addition, silencing circ_0067835 inhibited cytokines and ILC2s levels by down-regulating miR-155. 33908023 ZEB2-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cancer-adjacent tissues Expression[highly expressed] qRT-PCR//MTT//Transwell Assay The expression of lncRNA ZEB2-AS1 in gastric cancer tissues is significantly higher than in cancer-adjacent tissues. Yes According to scratch and Transwell assay, knocking down ZEB2-AS1 could remarkably inhibit the invasion and metastasis of AGS cells. 31128021 ZFAS1 LncRNA Homo sapiens Sepsis-Induced Cardiomyocyte Pyroptosis Serums of 22 patients with sepsis-induced myocardial injury (SIMI) and 24 healthy controls Interaction(miR-138-5p/SESN2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//FISH//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA Patients with SIMI had suppressed ZFAS1 and increased miR-138-5p expression when compared with those in healthy controls. MiR-138-5p is a target gene of ZFAS1, while miR-138-5p can negatively mediate SESN2. ZFAS1 alleviated sepsis induced cardiomyocyte pyroptosis by exerting competing endogenous RNA (ceRNA) function to indirectly regulate SESN2, which evidenced by loss and gain functions of ZFAS1 and SESN2. Yes LPS treatment in rats triggered myocardial injury accompanied by interstitial edema and moderate inflammatory cell infiltration. Besides, LPS caused elevated cell apoptosis rate and enhanced cell pyroptosis and inflammation in sepsis cell models.However, ZFAS1 overexpression or SESN2 overexpression in LPS induced rats and in H9C2 cells had meliorated myocardial injury and inflammatory response, indicating that ZFAS1 and SESN2 can inhibit sepsis-induced pyroptosis of cardiomyocytes. 34271014 ZFAS1 LncRNA Homo sapiens Heart Injuries H9C2 cells Interaction(miR-34b-5p/SIRT1) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//ELISA Our data revealed that ZFAS1 and SIRT1 were down-regulated, while miR-34b-5p was up-regulated in LPS-induced H9C2 cells. A mechanism study revealed that ZFAS1 sponged miR-34b-5p and thus elevated expression of SIRT1, which was prohibited by miR-34b-5p. ZFAS1 alleviated inflammatory response and cell apoptosis in LPS-stimulated H9C2 cells via the miR-34b-5p/SIRT1 axis, providing novel potential therapeutic targets for SIC. Yes Inhibition of miR-34b-5p or overexpression of ZFAS1 alleviated inflammatory response and cell apoptosis in LPS-stimulated H9C2 cells. 34340571 ZFAS1 LncRNA Homo sapiens Fatty Liver, Alcoholic HFD-managed models and patients Interaction(miR-144-5p) In Vivo Experiment The increase of ZFAS1 expression in patients with NAFLD was noted and the high expression level may be considered a risk factor for NAFLD. In mouse models fed with high-fat diet (HFD), the expression levels of ZFAS1 were increased; furthermore, sh-ZFAS1 reversed ZFAS1 overexpression.cMiR-144-5p was a ceRNA of ZFAS1; in addition, the expression of miR-144-5p was reduced in HFD-managed models and patients with NAFLD. ZFAS1 could successfully regulate the expression levels of miR-144-5p. In the present study, the negative relationship between ZFAS1 and miR-144-5p was documented. Yes HFD administration resulted in liver injury, which was indicated by increased lipid deposition, aggressive oxidative stress, and imbalanced inflammatory reaction. However, sh-ZFAS1 attenuated the abovementioned adverse effects of HFD. 36513253 Zfas1 LncRNA Mus musculus acute myocardial infarction cardiomyocytes Expression[highly expressed] Western Blot//qPCR//Tunel//Flow Cytometry//MTT//IF Overexpression of ZFAS1 in normal cardiomyocytes reduced the cell viability, similar to that observed in hypoxia-treated cardiomyocytes. Yes Overexpression of ZFAS1 in normal cardiomyocytes reduced the cell viability, similar to that observed in hypoxia-treated cardiomyocytes. 31819041 Zfas1 LncRNA Mus musculus Arthritis, Rheumatoid mice with RA-like symptoms Interaction((miR)-296-5p/MMP-15) Flow Cytometry//ELISA//Luciferase Report Assay//Bioinformatics Analysis ZFAS1 was next determined to be highly expressed in the mice with RA-like symptoms and TNF-α-stimulated MH7A cells while inhibiting ZFAS1 was demonstrated to promote proliferation and suppress apoptosis of MH7A cells.Moreover, RNA immunoprecipitation and dual-luciferase reporter assays identified the binding of ZFAS1 to microRNA (miR)-296-5p as well as the binding of miR-296-5p to matrix metalloproteinase-15 (MMP-15). Of note, ZFAS1 could bind miR-296-5p to up-regulate the expression of MMP-15. Yes Furthermore, ZFAS1 knockdown exerted anti-inflammation effect in vitro and in vivo and reduced the arthritis index value. 33191176 Zfas1 LncRNA Mus musculus Pulmonary Fibrosis lung tissues regulation[miR-150-5p/SLC38A1 axis] qRT-PCR Here, we found that lncRNA ZFAS1 was upregulated in bleomycin (BLM)-induced PF rats lung tissues and transforming growth factor-β1 (TGF-β1)-treated HFL1 cells, and positively correlated with the expression of solute carrier family 38 member 1 (SLC38A1), which is an important regulator of lipid peroxidation.Collectively, our studies demonstrated the role of the lncRNA ZFAS1/miR-150-5p/SLC38A1 axis in the progression of PF, and may provide a new biomarker for the treatment of PF patients. Yes Moreover, knockdown of lncRNA ZFAS1 significantly alleviated TGF-β1-induced fibroblast activation, inflammation and lipid peroxidation. In vivo experiments showed that inhibition of lncRNA ZFAS1 abolished BLM-induced lipid peroxidation and PF development. 32453709 circDYM CircRNA Mus musculus Hippocampal Neurons Injury hippocampus tissues of CUMS mice Interaction(miR-497a-5p/NR3C1 axis) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA Our study showed that circDYM and NR3C1 were downregulated and miR-497a-5p was upregulated in the hippocampus tissues of CUMS mice. In terms of mechanism, circDYM could upregulate NR3C1 by sponging miR-497a-5p. MiR-497a-5p overexpression reversed the regulation of circDYM on CUMS mice depressive-like behavior and hippocampal neurons injury. In addition, the function of miR-497a-5p overexpression on CUMS mice depressive-like behavior and hippocampal neurons injury also could be reversed by overexpressing NR3C1. Yes Overexpressed circDYM alleviated CUMS mice depressive-like behavior and repressed hippocampal neurons injury. 35413277 ZFAS1 LncRNA Rattus norvegicus Brain Ischemia FCI rats Interaction(miR-144-5p/FGF7 axis) In Vivo Experiment//Western Blot//Tunel//RIP//qRT-PCR//Luciferase Report Assay//H&E Staining ZFAS1 and FGF7 expression was elevated, while miR-144-5p expression was reduced in FCI rats. The augmented miR-144-5p or silenced FGF7 reversed the effects of enriched ZFAS1. ZFAS1 sponged miR-144-5p that targeted FGF7. Inhibition of lncRNA ZFAS1 improves functional recovery and angiogenesis after FCI via miR-144-5p/FGF7 axis. Yes Decreased ZFAS1 or FGF7 or enriched miR-144-5p repressed the inflammatory response, oxidative stress, neuronal apoptosis, while it improved angiogenesis, and neurological function recovery; while up-regulated ZFAS1 exerted opposite effects. 35012442 ZEB2-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cells Interaction[miR-143-5p/HIF-1α pathway ] CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay Collectively, our results indicated that ZEB2-AS1 was up-regulated in gastric cancer tissues and cells and promoted cell proliferation and metastasis through miR-143-5p/HIF-1α pathway, which may provide a promising target for treatment of gastric cancer. Yes Knockdown of ZEB2-AS1 suppressed gastric cancer cell proliferation, growth and invasion, and also suppressed in vivo tumor growth in the nude mice. Overexpression of ZEB2-AS1 potentiated gastric cancer cell proliferation, growth and invasion. 30705594 ZFAS1 LncRNA Homo sapiens Epilepsy SE mice and hippocampal neurons Interaction(miR-15a-5p/OXSR1/NF-κB pathway) Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Cell Apoptosis Assay//ELISA//EdU Staining LncRNA ZFAS1 was highly expressed in SE mice and SE-stimulated hippocampal neurons. MiR-15a-5p could be targeted by ZFAS1, and its inhibitor also reversed the suppressive effect of ZFAS1 knockdown on SE-induced hippocampal neurons injury. In addition, OXSR1 was a target of miR-15a-5p, and its silencing also could relieve SE-induced hippocampal neurons injury. OXSR1 overexpression reversed the inhibition effect of miR-15a-5p on SE-induced hippocampal neurons injury. Moreover, ZFAS1 positively regulated OXSR1 expression by sponging miR-15a-5p, thereby activating the NF-κB pathway. LncRNA ZFAS1 might contribute to the progression of epilepsy by regulating the miR-15a-5p/OXSR1/NF-κB pathway. Yes Silenced ZFAS1 promoted viability, while inhibited inflammation, apoptosis and oxidative stress in SE-induced hippocampal neurons. 35751788 ZEB2-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Regulation[Wnt/β-catenin pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay We found ZEB2-AS1 expression was increased in gastric carcinoma samples, and it was correlated with tumor progression. In conclusion, ZEB2-AS1 promotes the tumorigenesis of gastric carcinoma that is related to the upregulation of ZEB2 and the activation of the Wnt/β-catenin pathway. Yes Knockdown of ZEB2-AS1 reduced the proliferation, migration, invasion, and EMT, but increased the apoptosis of gastric carcinoma cells. 30635820 circSlc8a1 CircRNA Mus musculus Cardiac Hepatopathy mouse heart Expression(highly expressed) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//RNA-seq//IF In this study, we developed a circular antisense RNA (cA-circSlc8a1) that could silence the highly expressed circRNA circSlc8a1 in the mouse heart but not its parental Slc8a1 linear mRNA. Mechanistically, we found that circSlc8a1 translocated into mitochondria to drive ATP synthesis. Yes Transgenic cA-circSlc8a1 mice developed congestive heart failure resulting in a significant increase in the body weight secondary to peripheral edema and congestive hepatopathy. To further test the role of circSlc8a1, we generated transgenic mice overexpressing circSlc8a1 and observed a protective effect of circSlc8a1 in a pressure overload model. 36245125 ZEB2-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer cells Regulation Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Invasion Assay The ZEB2NAT knockdown caused anti-metastatic and apoptotic effects. The ZEB2NAT knockdown resulted in a decrease in ZEB2 and N-cadherin but an increase in E-cadherin protein levels. In addition, it was determined that ZEB2NAT knockdown significantly decreased cell proliferation and stimulated apoptosis in both cells. It was found that ZEB2NAT knockdown significantly decreased invasion and colony formation in both cells. ZEB2NAT knockdown showed anti-metastatic and apoptotic effect by affecting the important genes in both cells. Yes The ZEB2NAT knockdown caused anti-metastatic and apoptotic effects. The ZEB2NAT knockdown resulted in a decrease in ZEB2 and N-cadherin but an increase in E-cadherin protein levels. In addition, it was determined that ZEB2NAT knockdown significantly decreased cell proliferation and stimulated apoptosis in both cells. It was found that ZEB2NAT knockdown significantly decreased invasion and colony formation in both cells. ZEB2NAT knockdown showed anti-metastatic and apoptotic effect by affecting the important genes in both cells. 34418470 ZEB2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR ZEB2-AS1 was significantly increased in NSCLC tissues. Yes The knockdown of ZEB2-AS1 markedly inhibited the cell viability, migration, invasion, and EMT of A549 cells in vitro. 32611283 ZEB2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue and cells lines Interaction[miR-1205/CRKL Pathway] Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay//IF This analysis clarified that ZEB2-AS1 was upregulated in both CRC tissue sample and cells lines. Furthermore, the authors identified that the expression of ZEB2-AS1 was negatively correlated with expression of miR-1205, and CRKL could be a direct target of miR-1205. Through the gain-of-function experiments, they found that ZEB2-AS1 accelerates EMT in CRC cells via modulating the expression of miR-1205 and CRKL. This analysis clarified that ZEB2-AS1 was upregulated in both CRC tissue sample and cells lines; meanwhile, the high expression of ZEB2-AS1 was correlated with poor overall survival rate. Yes ZEB2-AS1 knockdown significantly suppresses the EMT in CRC cells. 31755734 ZEB2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues interaction[EZH2 and LSD1] RIP//qRT-PCR//EdU Staining ZEB2-AS1 was upregulated in CRC tissues relative to matched controls.It accelerates CRC cells to proliferate via interacting with EZH2 and LSD1, thus promoting the progression of CRC. Its level remained higher in CRC patients with ≥6 cm in tumor size, nodal metastasis and stage III-IV. CRC patients with low-level ZEB2-AS1 presented worse survival compared with those with high-level ZEB2-AS1. Yes Knockdown of ZEB2-AS1 attenuated the proliferative, migratory and invasive abilities, but induced apoptosis of DLD1 and SW620 cells. 32277632 ZEB2-AS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues and adjacent normal tissues,cell lines(HT-29，HCT116，SW620,LoVo,NCM460) Regulation[miR-143/bcl-2 axis ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay Our data showed that ZEB2-AS1 was significantly upregulated in CC tissues compared with adjacent normal tissues.Collectively, our results revealed that ZEB2-AS1 was upregualted and functioned as an oncogene via regulating miR-143/bcl-2 axis in colon cancer. Yes Functional assays showed that silencing ZEB2-AS1 expression remarkably inhibited proliferation, suppressed cell cycle transition while induced apoptosis in CC cells. 31497237 ZEB2-AS1 LncRNA Homo sapiens Colonic Neoplasms CC issues and adjacent normal tissues,cell lines(HCT8，SW480,HCT116) Interaction[ β-catenin ] CCK8//qRT-PCR//Western Blot We examined the expression levels of ZEB2-AS1 mRNA in 20 pairs of tumor tissues and adjacent normal tissues by RT-qPCR and found that the expression of ZEB2-AS1 was significantly upregulated in tumor tissues .Compared with normal colonic epithelial cell CCD 841 CoN, ZEB2-AS1 expression was significantly upregulated in CC cell lines, such as HCT8, SW480 and HCT116 cells.ZEB2-AS1 could promote colon cancer cell proliferation and inhibit apoptosis to promote the progression of colon cancer by upregulating the expression of β-catenin protein. Yes In colon cancer cell line of HCT8, overexpression of ZEB2-AS1 could promote cell proliferation and migration, while silencing ZEB2-AS1 would enhance cell apoptosis and inhibit proliferation. 31698657 ZFAS1 LncRNA Homo sapiens Epilepsy, Temporal Lobe Serum Expression(highly expressed) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//ELISA Serum levels of Zfas1 were higher in TLE patients than in healthy controls (p<0.05). Transfection of pcDNA-Zfas1 weakened the viability and proliferation of neurons and increased neuronal apoptosis (p<0.05). Meanwhile, pcDNA3.1-Zfas1 transfection promoted lipopolysaccharide-induced release of cytokines, including tumor necrosis factor-α, interleukin (IL)-1, IL-6, and intercellular adhesion molecule-1 (p<0.05), and boosted NF-κB activation by elevating the expression of NF-κB p65, pIκBα, and IKKβ in neurons (p<0.05). Yes Transfection of pcDNA-Zfas1 weakened the viability and proliferation of neurons and increased neuronal apoptosis (p<0.05). 33635011 ZFAS1 LncRNA Homo sapiens Epilepsy hippocampal neurons regulation[PI3K/AKT pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay ZFAS1 expression was elevated in hippocampus and hippocampal neurons from SE mice. Interference of ZFAS1 attenuated hippocampal neurons apoptosis and autophagy in SE by increasing miR-421 and activating the PI3K/AKT pathway, indicating a new mechanism for understanding the pathogenesis of SE. Yes Knockdown of ZFAS1 increased SE hippocampal neurons viability and decreased apoptosis and autophagy. 32725369 mmu_circ_37492 CircRNA Mus musculus Nephrogenic Fibrosing Dermopathy BUMPT cells and C57BL/6 mice Interaction(mmu_circRNA_37492/hsa_circ_0012138) In Vivo Experiment//qRT-PCR//FISH//Luciferase Report Assay//IHC In conclusion, we for the first time demonstrated that circRNA_37492 attenuated renal fibrosis via targeting miR-7682-3p/Fgb axis, and the homologous hsa_circRNA_0012138 was speculated as a possible ceRNA to regulate multiple gene expressions and involve in human renal fibrosis, suggesting that circRNA_37492/hsa_circ_0012138 may serve as potent therapy target for obstructive renal fibrosis disease. Yes In vivo, overexpression of circRNA_37492 attenuated fibrotic lesions in the kidneys of UUO mice via targeting miR-7682-3p/Fgb axis. 35246505 ZFAS1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Interaction[miR-10a/SKA1 pathway] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay We observed that high-level expression of ZFAS1 is positively correlated with poor prognosis and shorter overall survival (OS) in patients with ccRCC.Furthermore, miR-10a was identified as a target of ZFAS1. Silencing miR-10a could attenuate the ability of ZFAS1 in promoting proliferation and metastasis of ccRCC. Subsequently, our studies validated that SKA1, as a key downstream target protein for miR-10a, is responsible for the biological role of ZFAS1. ZFAS1 positively regulated SKA1 expression via sponging miR-10a. We observed that high-level expression of ZFAS1 is positively correlated with poor prognosis and shorter overall survival (OS) in patients with ccRCC. Yes Knockdown of ZFAS1 significantly suppressed proliferation, migration and invasion of ccRCC cells. 30841471 ZFAS1 LncRNA Homo sapiens Melanoma melanoma tissues and cell lines Regulation[ZFAS1/miR-150-5p/RAB9A axis] Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay ZFAS1 expression in metastatic tissues was higher than that in nonmetastatic subjects.There was a direct binding between ZFAS1 and miR-150-5p. ZFAS1 negatively regulated miR-150-5p expression and upregulation of miR-150-5p was involved in ZFAS1 knockdown-induced effect on proliferation, apoptosis, migration, and invasion. Using bioinformatics, we predicted the binding between RAB9A and miR-150-5p, and the direct interaction between RAB9A and miR-150-5p was confirmed by luciferase reporter and RNA immunoprecipitation assays. We also showed that RAB9A expression was regulated negatively by miR-150-5p, but was regulated positively by ZFAS1. Downregulation of RAB9A significantly inhibited the increase in proliferation, decrease in apoptosis, and increase in migration and invasion induced by miR-150-5p inhibitors. Moreover, RAB9A knockdown decreased proliferation, increased apoptosis, and decreased migration and invasion in melanoma cells. Higher expression of ZFAS1 predicted lower survival rates. Yes Knockdown of ZFAS1 decreased proliferation, increased apoptosis, decreased migration and invasion, and reduced epithelial-mesenchymal transition potential in melanoma cells. Moreover, ZFAS1 knockdown inhibited tumor growth in nude mice. 30889053 ZFAS1 LncRNA Homo sapiens Pancreatic Carcinoma PC tissues and cells Interaction(U2AF2/HMGCR ) RNA Pull-Down//Western Blot//qRT-PCR//Colony Formation Assay//Transwell Assay ZFAS1 was kept at a high level in PC tissues versus the normal counterparts. Mechanistically, ZFAS1 stabilized HMGCR mRNA through U2AF2, thus increasing HMGCR expression and promoting PC lipid accumulation. Yes ZFAS1 gene knockout remarkably suppressed PC cell multiplication and invasiveness and decreased the contents of free fatty acids, total cholesterol, triglycerides, and phospholipids. 35846429 ZFAS1 LncRNA Homo sapiens Laryngeal Neoplasms laryngeal cancer tissues and cells Interaction(RBFOX2/MENA ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//Cell Proliferation Assay//cell invasion assay//IF Here, we found that ZFAS1 expression in laryngeal cancer tissues and cells was higher than that in adjacent normal tissues and normal nasopharyngeal epithelial cells. Mechanistically, ZFAS1 stabilized RNA binding fox-1 homolog 2 (RBFOX2) protein expression by binding to RBFOX2, and RBFOX2 overexpression reversed the effect of ZFAS1 silence on cell functions. Moreover, highly expressed RBFOX2 led to skipping of MENA exon 11a and generating a pro-invasive isoform (MENAINV ). MENAINV overexpression effectively abolished the inhibitory effect of RBFOX2 knockdown on cell malignant progression. Highly expressed ZFAS1 was associated with advanced lymph node metastasis stages and clinical stages. Yes ZFAS1 overexpression promoted LC cell proliferation, invasion, and N-cadherin and Vimentin expression, and suppressed E-cadherin expression. While ZFAS1 knockdown played an opposite role. 36336961 ZFAS1 LncRNA Homo sapiens Myocardial Infarction cardiac fibroblasts Regulation(Wnt/β-catenin signaling pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//IHC//Transwell Assay Knockdown of ZFAS1 also suppressed Wnt/β-catenin pathway in vivo. The inhibition of Wnt/β-catenin remarkably reversed the influence of shZFAS1 on cardiac function and cardiac fibroblasts viability. Yes Knockdown of ZFAS1 significantly increased the proliferation, migration, and invasion of cardiac fibroblasts. Knockdown of ZFAS1 remarkably improved cardiac function via decreasing infarction ratio and increasing vWF expression, left ventricular ejection fraction, and left ventricular fractional shortening compared with group MI. 33952724 mmu_circ_0001295 CircRNA Mus musculus Renal Injury chemokine and cytokine plasma Expression(lower expressed) qRT-PCR//RNA-seq Treatment with ADSC exosomes (Exo), particularly those with hypoxic pretreatment (HExo), enhanced survival, suppressed renal vascular leakage and decreased kidney dysfunction in septic mice. HExo ameliorated sepsis-induced increases in chemokine and cytokine plasma levels. Furthermore, the HExo circRNA content, determined through next-generation sequencing, revealed abundant mmu_circ_0001295. Further studies demonstrated that downregulation of exosomal mmu_circ_0001295 suppressed the exosomes' protective effects against sepsis. HExo prevented microvascular dysfunction, thus potentially improving sepsis outcomes via mmu_circ_0001295 delivery. In summary, the data indicated that HExo elongate sepsis-induced renal injury through delivering mmu_circ_0001295. Yes Further studies demonstrated that downregulation of exosomal mmu_circ_0001295 suppressed the exosomes' protective effects against sepsis. HExo prevented microvascular dysfunction, thus potentially improving sepsis outcomes via mmu_circ_0001295 delivery. 35212606 ZFAS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[ZFAS1/miR-590-3p axis ] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay Our results demonstrated that lncRNA ZFAS1 expression was significantly upregulated in NSCLC tissues and cell lines.Therefore, our study indicates that lncRNA ZFAS1/miR-590-3p axis is involved in NSCLC cell proliferation. Yes Loss-of-function experiments revealed that lncRNA ZFAS1 inhibition could remarkably suppress NSCLC cells proliferation in vitro. 32841053 ZFAS1 LncRNA Homo sapiens Hepatoblastoma HB tissues and cell lines Interaction[HGF/c-Met Pathway ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay Here we showed that the expression of ZFAS1 was significantly upregulated in both HB tissues and cell lines. Furthermore, miR-193a-3p was identified to be the target of ZFAS1. Subsequently, RALY was confirmed to be regulated by miR-193a-3p/ZFAS1 axis. Mechanistically, our results indicated that the ZFAS1 participated to the progression of HB via regulating the HGF/c-Met signaling. Collectively, these data demonstrated that ZFAS1 acted as an oncogene to promote initiation and progression of HB by regulating miR-193a-3p/RALY (RALY Heterogeneous Nuclear Ribonucleoprotein) axis via HGF/c-Met Pathway, which provides an efficient marker and new therapeutic target for HB. High ZFAS1 expression was significantly associated with aggressive tumor phenotypes and poorer overall survival in HB. Yes In vitro and in vivo function assays indicated that silencing of ZFAS1 significantly suppressed HB cell proliferation and invasion. 31781561 ZFAS1 LncRNA Homo sapiens Diabetic Cardiomyopathies db/db mice Interaction(miR-150-5p /CCND2) In Vivo Experiment//RNA Pull-Down//Transfection//qRT-PCR//Luciferase Report Assay//Microarray//IF Microarray data analysis of DbCM in patients or mouse models from GEO revealed the significance of ZFAS1 and the significant downregulation of miR-150-5p and CCND2. Inhibition of ZFAS1 led to reduced collagen deposition, decreased cardiomyocyte apoptosis and ferroptosis, and attenuated DbCM progression.ZFAS1 sponges miR-150-5p to downregulate CCND2 expression. Ad-sh-ZFAS1, miR-150-5p mimic, and Ad-CCND2 transfection attenuated ferroptosis and DbCM development both in vitro and in vivo.lncRNA-ZFAS1 acted as a ceRNA to sponge miR-150-5p and downregulate CCND2 to promote cardiomyocyte ferroptosis and DbCM development. Yes Inhibition of ZFAS1 led to reduced collagen deposition, decreased cardiomyocyte apoptosis and ferroptosis, and attenuated DbCM progression. ZFAS1 sponges miR-150-5p to downregulate CCND2 expression. Ad-sh-ZFAS1, miR-150-5p mimic, and Ad-CCND2 transfection attenuated ferroptosis and DbCM development both in vitro and in vivo. 34609043 ZFAS1 LncRNA Homo sapiens Hirschsprung Disease 30 children diagnosed with HSCR and 30 control cases, SH-SY-5Y cells Expression(highly expressed) Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining Compared with the control group, the HSCR group has a significantly higher level of ZFAS1(P = 0.0012). Functionally, over-expression of ZFAS1 significantly inhibited cell proliferation, whereas knockdown of ZFAS1 promoted cell proliferation and colony formation of SH-SY-5Y cells. Yes Functionally, over-expression of ZFAS1 significantly inhibited cell proliferation, whereas knockdown of ZFAS1 promoted cell proliferation and colony formation of SH-SY-5Y cells. 34993837 ZFAS1 LncRNA Homo sapiens Polycystic Ovary Syndrome ovarian granulosa cells interaction[miR-129,HMGB1 ] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//ELISA//EdU Staining//IF LncRNA ZFAS1 and HMGB1 were elevated, while miR-129 was down-regulated in ovarian granulosa cells of PCOS patients.LncRNA ZFAS1 could bind to miR-129 to promote HMGB1 expression, thereby affecting the endocrine disturbance, proliferation and apoptosis of ovarian granulosa cells in PCOS. Yes Down-regulated lncRNA ZFAS1 or overexpressed miR-129 could decrease HMGB1 expression, increase P4 and E2 secretion, promote proliferation activity while inhibit apoptosis of ovarian granulosa cells in PCOS. 32320818 ZFAS1 LncRNA Homo sapiens Arthritis, Rheumatoid RA synovial tissues regulation[ ZFAS1/miR-2682-5p/ADAMTS9 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//ELISA High levels of ZFAS1 and ADAMTS9, and a low level of miR-2682-5p were observed in RA synovial tissues and FLS-RA. ZFAS1/miR-2682-5p/ADAMTS9 axis could modulate the cell behaviors, inflammatory response in FLS-RA, might provide a potential therapeutic target for RA treatment. Yes Knockdown of ZFAS1 led to the curbs of cell proliferation, inflammation, autophagy, and boost apoptosis in FLS-RA, while these effects were abolished via regaining miR-2682-5p inhibition. 32744323 ZFAS1 LncRNA Homo sapiens Arthritis, Rheumatoid RA synovial tissues and RA-FLSs Interaction(miR-3926/FSTL1 ) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The results demonstrated that ZFAS1 and FSTL1 were upregulated, and miR-3926 was downregulated in RA synovial tissues and RA-FLSs.In conclusion, ZFAS1 knockdown inhibited RA-FLS proliferation, migration, invasion and inflammatory cytokine production, and induced apoptosis in RA via the miR-3926/FSTL1 axis. Yes ZFAS1 knockdown suppressed cell proliferation, migration, invasion and inflammatory cytokine production, and induced apoptosis in RA-FLSs. 34306188 circCSNK1G1 CircRNA Mus musculus Thyroid Neoplasms tumor tissues of thyroid cancer Regulation(miR-149-5p) In Vivo Experiment//IHC//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay The present work discovered the upregulation of circ-CSNK1G1 in tumor tissues of thyroid cancer. In function, circ-CSNK1G1 knockdown inhibited proliferation, survival, and invasion in cancer cells, and tumor growth in mouse models. MiR-149-5p was a target of circ-CSNK1G1, and the anti-tumor effects of circ-CSNK1G1 knockdown were abolished by miR-149-5p downregulation. In addition, miR-149-5p directly targeted MAPK1, and miR-149-5p restoration-inhibited cell proliferation and invasion were recovered by MAPK1 overexpression. Yes In function, circ-CSNK1G1 knockdown inhibited proliferation, survival, and invasion in cancer cells, and tumor growth in mouse models. 35023214 circGSE1 CircRNA Mus musculus Aging OECs & YECs Regulation(miR-323-5p/NRP1 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Tube Formation Assay//qRT-PCR//RIP//FISH//Luciferase Report Assay//EdU Staining//Transwell Assay Our study showed that circGSE1 could promote the proliferation, migration and tube formation of OECs in vitro. In a mouse model of femoral artery ligation and ischemia, circGSE1 promoted blood flow recovery and angiogenesis in the ischemic limbs of ageing mice. Mechanistically, we found that overexpressing circGSE1 reduced miR-323-5p expression, increased neuropilin-1 (NRP1) expression, and promoted proliferation, migration, and tube formation in OECs, while knocking down circGSE1 increased miR-323-5p expression, reduced NRP1 expression, and inhibited proliferation, migration, and tube formation in YECs. During EC ageing, circGSE1 may act through the miR-323-5p/NRP1 axis and promote endothelial angiogenesis in mice. Finally, the circGSE1/miR-323-5p/NRP1 axis could serve as a potential and promising therapeutic target for angiogenesis during ageing. Yes Mechanistically, we found that overexpressing circGSE1 reduced miR-323-5p expression, increased neuropilin-1 (NRP1) expression, and promoted proliferation, migration, and tube formation in OECs, while knocking down circGSE1 increased miR-323-5p expression, reduced NRP1 expression, and inhibited proliferation, migration, and tube formation in YECs. 35366240 ZFAS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer Interaction( MicroRNA-200b and microRNA-200c) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//Transwell Assay This analysis identified lncRNA ZFAS1 as significantly increased in colon cancer compared to normal colon epithelium. MicroRNA-200b and microRNA-200c (miR-200b and miR-200c) are experimentally validated targets of ZFAS1, and this interaction was confirmed using reciprocal gene knockdown. ZFAS1 knockdown regulated ZEB1 gene expression and downstream targets E-cadherin and vimentin. Knockdown of miR-200b or miR-200c reversed the effect of ZFAS1 knockdown in the ZEB1/E-cadherin, vimentin signaling cascade, and the effects of cellular migration and invasion, but not cellular proliferation. Yes ZFAS1 knockdown was associated with decreased cellular proliferation, migration, and invasion in two colon cancer cell lines (HT29 and SW480). ZFAS1 knockdown was also associated with decreased tumor growth in an in vivo mouse model. 33771981 ZFAS1 LncRNA Homo sapiens gastric cardia adenocarcinoma GCA tissues Expression[highly expressed] CCK8//qRT-PCR//ChIP//Western Blot We demonstrated here that the LncRNA ZFAS1 was up-regulated in GCA tissues. Furthermore, the elevated level of ZFAS1 was significantly associated with the GCA metastasis and cancer recurrence. It was also demonstrated to be an independent prognostic indicator of disease-free survival and overall survival for GCA patients. Yes In vitro studies showed that the ZFAS1 could bind to EPAS1, enhance its abilities to epigenetically silence the HIF1, and promote its own expression in GCA cell lines. 33364040 ZFAS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues with paired adjacent normal tissue Regulation[microRNA-200b-3p/Wnt1 axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Our data showed that ZFAS1 in gastric tissues was highly expressed, compared with the para-carcinoma tissues. Summarily, we demonstrated a critical role of miR-200b in gastric cancer, and ZFAS1 can promote malignant progression through regulating miR-200b mediated Wnt/β-catenin signaling. Yes In vivo, ZFAS1 knockdown suppressed the tumorigenesis with the upregulated miR-200b and the inactive Wnt/β-catenin signaling. 30999814 ZFHX4-AS1 LncRNA Homo sapiens Ovarian Neoplasms OvCa tissue & OvCa cells Expression(highly expressed) qRT-PCR//Wound Healing Assay//Western Blot The expression of lncRNA ZFHX4-AS1 was upregulated in OvCa relative to that in normal tissues. Increased lncRNA ZFHX4-AS1 expression was associated with poor overall survival and progression-free survival in OvCa. The GO and KEGG pathway analyses revealed the role of lncRNA ZFHX4-AS1 in cell metabolism, protein synthesis, cell proliferation, and cell cycle. GSEA indicated the hallmark gene sets that were significantly enriched in the high and low expression groups. The CIBERSORT database revealed M2 macrophages, memory B-cells, naïve B cells, and activated NK cells were affected by lncRNA ZFHX4-AS1 expression (all P < 0.05). The expression of lncRNA ZFHX4-AS1 and its related differential genes MRPS11, NSA2, and MRPL13 were significantly correlated with the immune checkpoints. Knockdown of lncRNA ZFHX4-AS1 could inhibit the proliferation, invasion and migration of OvCa cells. The expression of lncRNA ZFHX4-AS1 was upregulated in OvCa relative to that in normal tissues. Increased lncRNA ZFHX4-AS1 expression was associated with poor overall survival and progression-free survival in OvCa. Yes Knockdown of lncRNA ZFHX4-AS1 could inhibit the proliferation, invasion and migration of OvCa cells. 35903691 WEE2-AS1 LncRNA Homo sapiens Arteriosclerosis Obliterans artery tissue,blood Expression[highly expressed] CCK8//qRT-PCR//Flow Cytometry//Western Blot The results indicated that lncRNA WEE2?AS1 was significantly elevated in plasma and artery tissue samples of patients with ASO compared with healthy controls. Yes The Cell Counting Kit?8 assay results suggested that lncRNA WEE2?AS1 knockdown significantly promoted HUVEC viability, whereas lncRNA WEE2?AS1 overexpression inhibited HUVEC viability compared with the negative control groups. 33174040 ZNF561-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC patient tissues Interaction(miR-26a-3p/miR-128-5p-SRSF6 axis) RIP//qRT-PCR//Luciferase Report Assay//Tunel We find that ZNF561-AS1 and SRSF6 were upregulated in CRC patient tissues. ZNF561-AS1 expression was reduced in tissues from treated CRC patients but upregulated in CRC tissues from relapsed patients. SRSF6 expression was suppressed and enhanced by ZNF561-AS1 depletion and overexpression, respectively. Mechanistically, ZNF561-AS1 regulated SRSF6 expression by sponging miR-26a-3p and miR-128-5p. ZNF561-AS1-miR-26a-3p/miR-128-5p-SRSF6 axis was required for CRC proliferation and survival. Yes ZNF561-AS1 knockdown suppressed CRC cell proliferation and triggered apoptosis. ZNF561-AS1 depletion suppressed the growth of tumors in a model of a nude mouse xenograft. Similar observations were made upon SRSF6 depletion. SRSF6 overexpression reversed the inhibitory activities of ZNF561-AS1 in vivo, as well as in vitro. 33622363 ZNF609 CircRNA Homo sapiens Glioma glioma cells Interaction(miR-378b/SLC2A1 axis) Western Blot//Transfection//RIP//PCR//IP//IF Mechanically, miR-378b was sponged by ZNF609 and targeted SLC2A1 in glioma cells. ZNF609 enhanced SLC2A1 expression by inhibiting miR-378b. The inhibition of miR-378b or the enhancement of SLC2A1 reversed ZNF609 depletion-regulated glioma cell proliferation in vitro. Yes Remarkably, knockdown of ZNF609 by siRNA in glioma cells reduced cell viabilities and Edu-positive. The silencing of ZNF609 stimulated the apoptosis of glioma cells. Meanwhile, the ZNF609 depletion inhibited the invasion and migration of glioma cells. In glioma cells, the mRNA and protein expression of E-cadherin was enhanced, while Vimentin was reduced by the inhibition of ZNF609. The glucose uptake, lactate product, and ATP production in glioma cells were suppressed by ZNF609 knockdown. 34520391 ZNF609 CircRNA Homo sapiens Nasopharyngeal carcinoma nasopharyngeal epithelial tissues Interaction[competing with microRNA-150-5p] qRT-PCR//Western Blot//PCR//IF The expression levels of circ-ZNF609 and Sp1 in NPC tissues were markedly higher than those of normal nasopharyngeal epithelial tissues. Dual-Luciferase reporter gene assay revealed that circ-ZNF609 could bind to microRNA-150-5p, and Sp1 was a target gene of microRNA-150-5p. Western blot results showed that circ-ZNF609 could stabilize the expression of Sp1, while microRNA-150-5p degraded Sp1 expression. Furthermore, the knockdown of Sp1 in NPC cells reversed the carcinogenic effect of circ-ZNF609. Yes The knockdown of circ-ZNF609 in NPC cells 5-8F and HONE-1 significantly inhibited the proliferative, migratory and invasive behaviors of NPC cells. 31002133 ZNF609 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC cells and NPC samples Interaction(miR-145/STMN1 axis) RNA Pull-Down//Western Blot//Transfection//Migration Assay//Proliferation Assay//qRT-PCR//migration assay//PCR//Cell Proliferation Assay//ELISA//IF Here, we showed that circ-ZNF609 and STMN1 expression was increased, while miR-145 expression was decreased in NPC cells and NPC samples. Our data suggested that circ-ZNF609 promotes cell proliferation, migration, and angiogenesis in NPC by upregulating the expression of STMN1 by sponging miR-145 in NPC. Yes Circ-ZNF609 may negatively regulate miR-145 expression by acting as a ceRNA. Silencing circ-ZNF609 suppressed cell proliferation, migration, and angiogenesis in NPC, while knockdown of miR-145 reversed these effects. 33943007 ZNF609 CircRNA Homo sapiens Thyroid Neoplasms TC cells Interaction(miR-514a-5p) colony Formation Assay//Western Blot//Wound Healing Assay//Transfection//qRT-PCR//PCR//cell invasion assay//Colony Formation Assay//Invasion Assay//IF The data indicated that circ-ZNF609 was highly expressed, while miR-514a-5p was downregulated in TC cells.The findings highlighted the importance of circ-ZNF609 function in facilitating TC cell development and metastasis in vitro and in vivo via binding to miR-514a-5p. Yes Circ-ZNF609 knockdown prevented the malignant biological behaviors of TPC-1 and IHH-4 cells. 35135416 ZNF609 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cells Interaction(microRNA-134-5p) colony Formation Assay//Western Blot//Transfection//qRT-PCR//RIP//PCR//BrdU//IP//Colony Formation Assay//Invasion Assay//IF CircZNF609 was upregulated in LSCC and associated with poor survival of LSCC patients. CircZNF609 can regulate miR-134-5p to upregulate epidermal growth factor receptor (EGFR). In addition, knockdown of EGFR or overexpression of miR-134-5p could reverse the tumor-promoting effects of circZNF609 in LSCC. In LSCC tissues, circZNF609 was negatively correlated with miR-134-5p and positively correlated with EGFR. CircZNF609 promotes the progression of LSCC via the miR-134-5p/EGFR axis, which might be the therapeutic target of LSCC. CircZNF609 was upregulated in LSCC and associated with poor survival of LSCC patients. Yes Knockdown of circZNF609 inhibited LSCC proliferation, invasion and the expression of PCNA and matrix matalloproteinases-2 (MMP-2). 35236250 ZNF609 CircRNA Homo sapiens Melanoma melanoma cells Interaction(miR-138-5p/SIRT7 axis) Western Blot//Wound Healing Assay//qPCR//IF//MTT//PCR//Transwell Assay Meanwhile, comet assays showed that the tail length and γH2AX levels were elevated by circZNF609 depletion. Mechanically, circZNF609 sponged miR-138-5p and miR-138-5p targeted SIRT7 in the melanoma cells. The SIRT7 overexpression and miR-138-5p inhibitor could reverse circZNF609 depletion-mediated DNA damage and malignant progression in melanoma cells. Yes The circZNF609 depletion significantly suppressed melanoma cell invasion, migration, and proliferation, and stimulated apoptosis. Functionally, CircZNF609 promoted cell growth of melanoma in the nude mice. 34370715 ZNF609 CircRNA Homo sapiens Carcinoma, Renal Cell cell lines Interaction[sponging miR-138-5p] qRT-PCR//PCR//IF And we found that circ-ZNF609 is significantly increased in renal carcinoma cell lines. The direct interaction between microRNA-138-5p (miR-138-5p) and forkhead box P4 (FOXP4) or circ-ZNF609 was confirmed by luciferase reporter assay and RNA immunoprecipitation assay. In short, our current study reveals the role of the circ-ZNF609/miR-138-5p/FOXP4 regulatory network in renal carcinoma and provides a new perspective for the pathogenesis of renal Yes In addition, the high expression of circ-ZNF609 promotes cell proliferation and invasion ability. 30478938 ZNF609 CircRNA Homo sapiens Acute Kidney Injury HK-2 cells, patients Regulation(AKT/mTORautophagy pathway) Western Blot//Transfection//PCR//Cell Viability Assay//IF Herein, we find that circ-ZNF609, originating from the ZNF609 locus, is highly expressed in the kidney after ischemia/reperfusion injury, and urinary circ-ZNF609 is a moderate predictor for AKI in heart disease patients. Mechanistically, circ-ZNF609 encodes a functional protein consisting of 250 amino acids (aa), termed ZNF609-250aa, the overexpression of which can activate AKT3/mTOR signaling and induce autophagy flux impairment and cell apoptosis in HK-2 cells in vitro and in AKI kidneys in vivo. The blockade of AKT and mTOR signaling with pharmacological inhibitors is capable of reversing ZNF609-250aa-induced autophagy flux impairment and cell apoptosis in HK-2 cells. Yes Overexpression of circ-ZNF609 can activate AKT3/mTOR signaling and induce autophagy flux impairment and cell apoptosis while inhibiting proliferation in HK-2 cells, which is blocked by silencing circ-ZNF609. 36110046 ZNF561-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues and cells Interaction(miR-302a-3p/PDGFD) Other ZNF561-AS1 was elevated in hepatocellular carcinoma tissues and cells.. ZNF561-AS1 bind to miR-302a-3p, and decreased expression of miR-302a-3p in hepatocellular carcinoma. Moreover, miR-302a-3p reduced platelet-derived growth factor-D (PDGFD) in hepatocellular carcinoma, and inhibition of miR-302a-3p attenuated ZNF561-AS1 silence-induced decrease of PDGFD. Yes Silence of ZNF561-AS1 reduced cell viability and inhibited the proliferation of hepatocellular carcinoma. The angiogenesis of hepatocellular carcinoma was also suppressed by loss of ZNF561-AS1 with a decrease of angiopoietin 2, fibroblast growth factor 1, and vascular endothelial growth factor. 36308081 ZNF609 LncRNA Homo sapiens Lung Neoplasms cell lines regulation[miR-142-3p/GNB2 axis] qRT-PCR//Luciferase Report Assay//FISH In current work, it was discovered that circZNF609 functioned as an onco-circRNA, which exhibited high expression as well as facilitated the proliferation and migration in LC cells.Conclusively, the results indicated that FUS-induced circZNF609 exerts promotional effects on LC cell proliferation and migration through modulation of the miR-142-3p/GNB2 axis, which could offer new insight for understanding LC. Yes LC cells were transfected with silenced circZNF609 by siRNAs, and cell proliferation, migration, and apoptosis were evaluated to reflect the influences of circZNF609 knockdown in LC. 33459380 ZNF561-AS1 LncRNA Homo sapiens Myocardial Infarction MI mice Interaction(miR-223-3p/NLRP3 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Flow Cytometry//RIP//FISH//Luciferase Report Assay//H&E Staining//IHC//EdU Staining In addition, we conducted a series of rescue experiments to affirm that ZNF561-AS1 regulated cell proliferation and apoptosis in MI through miR-223-3p/NLRP3 axis. Yes In addition, we conducted a series of rescue experiments to affirm that ZNF561-AS1 regulated cell proliferation and apoptosis in MI through miR-223-3p/NLRP3 axis. 35997481 hsa_circ_0075932 CircRNA Rattus norvegicus Infections obese rats and THP-1 cells Regulation Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//ELISA Luciferase assays indicated that miR-142 effectively suppressed the expression of circRNA_0075932/NLRP3 while miR-495 inhibited the expression of circRNA_0075932/PUM2. Downregulation of circRNA_0075932 suppressed the expression of circRNA_0075932/NLRP3/PUM2 and activated the expression of miR-142/miR-495. Yes Exosomes collected from lenti-circRNA_0075932 shRNA-treated ADSCs showed remarkable efficiency in maintaining the post heat stress (PHS)-induced dysregulation of circRNA_0075932, miR-142, miR-495, NLRP3, PUM2, AuroraB, Ika, NF-kB, TNF-α, IL-1β, and MCP-1 in THP-1 cells. Moreover, EXO-Lenti-circRNA_0075932 shRNA significantly restored burn-induced dysregulation of circRNA_0075932, miR-142, miR-495, NLRP3, PUM2, AuroraB, Ika, NF-kB, TNF-α, IL-1β, and MCP-1 in obese rats. 35397427 ZNF503-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cells regulation[GATA6] qRT-PCR//Luciferase Report Assay//RIP//ChIP Microarray-based expression profile analysis of the GEO GSE61615 dataset revealed that the expression of ZNF503-AS1 was decreased in bladder cancer.ZNF503-AS1 and SLC8A1 were found to be down-regulated in both primary bladder cancer tissues and cells.ZNF503-AS1 can recruit transcription factor GATA6 to up-regulate SLC8A1 expression, thereby increasing the intracellular Ca2+ concentration and repressing the proliferation, invasion and migration, and enhancing the apoptosis of bladder cancer cells. Yes Exogenous overexpression of ZNF503-AS1 or SLC8A1 attenuated bladder cancer cell proliferation, invasion and migration, but promoted their apoptosis, accompanied by decreased Ca2+-ATPase activities and increased intracellular Ca2+ concentrations. 33001357 ZNF503-AS1 LncRNA Homo sapiens Diabetic Retinopathy patients with diabetic retinopathy Regulation( TGF-β signaling) Western Blot//Transfection//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay We found that ZNF503-AS1 was not differentially expressed in healthy participants and diabetic patients. Plasma lncRNA ZNF503-AS1 level was higher in patients with diabetic retinopathy than in patients with other complications (p < 0.05). We concluded that ZNF503-AS1 might participate in diabetic retinopathy by activating TGF-β signaling. High plasma lncRNA ZNF503-AS1 level was correlated with a high incidence of diabetic retinopathy. Yes ZNF503-AS1 overexpression inhibited proliferation, promoted cell apoptosis, and upregulated TGF-β1 expression (p < 0.05). 35734878 ZNF451-AS1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tumor tissues and cell lines Interaction(ZNF451) CCK8//qRT-PCR//Wound Healing Assay//Western Blot The results revealed that the BC032020 levels in the PDAC tumor tissues were lower than those in the adjacent normal tissues, and ZNF451 expression inversely correlated with the BC032020 levels in the PDAC tumor tissues and cell lines. Taken together, the findings of this study indicate that BC032020 suppresses the survival of PDAC cells by inhibiting ZNF451 expression. Yes BC032020 overexpression led to a decrease in ZNF451 expression; it also suppressed the proliferation and migration of the AsPC?1 and PANC?1 cells, and induced G1 phase arrest and cell apoptosis. The results of in vivo experiments revealed that BC032020 suppressed tumor growth in a xenograft model by inhibiting ZNF451 expression. 29532883 hsa_circ_001839 CircRNA Rattus norvegicus Renal Ischemia-Reperfusion Injury RI-RI rats and NRK52E cells Interaction(miR-432-3p) qRT-PCR//Transfection//Luciferase Report Assay//Western Blot Circ 001839 expression of RI-RI rats and NRK52E cells was significantly upregulated, compared with the control group. Circ 001839 overexpression significantly increased inflammation through promoting TNF-α, IFN-γ, and IL-6 expression levels in NRK52E cells. Overexpression of miR-432-3p significantly promoted inflammation in NRK52E cells via induction of NLRP3. Moreover, miR-432-3p decreased the effects of circ 001839-induced inflammation in NRK52E cells. Yes Circ 001839 overexpression significantly increased inflammation through promoting TNF-α, IFN-γ, and IL-6 expression levels in NRK52E cells. 33975327 ZNF407-AS1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissue Interaction(miR-23b-3p/MRC2 Axis) qRT-PCR//Wound Healing Assay//Luciferase Report Assay In receiver operating characteristic (ROC) analysis, our results revealed that serum LINC00909 distinguished cancers from normal ovarian tissue with 87.8% of sensitivity and 69.6% of specificity (AUC, 81.2%) and distinguished serous ovarian cancer from normal ovarian tissue with 90.0% of sensitivity and 75.9% of specificity (AUC, 84.5%). Besides, we demonstrated that LINC00909 functions as a competing endogenous RNA (ceRNA) of MRC2 mRNA by sponging miR-23-3p, and thereby promotes epithelial-to-mesenchymal transition (EMT) of ovarian cancer cells. Also, patients with low serum LINC00909 level showed a longer overall (hazard ratio, HR = 1.874, p = 0.0004) and progression-free (HR = 1.656, p = 0.0017) survival. Yes Functional assays indicated that the elevation of LINC00909 expression contributes to cell proliferation, migration, and invasion capability of ovarian cancer cells. 34336102 ZNF609 CircRNA Homo sapiens Glioma 62 glioma tissues and 15 non-glioma tissues Interaction(miR-1224-3p/PLK1 signaling) Western Blot//Proliferation Assay//qRT-PCR//IF//PCR//Cell Proliferation Assay//IP//Transwell Assay Circ-ZNF609 was confirmed prominently upregulated in glioma. Mechanistically, circ-ZNF609 could promote PLK1 expression via binding to miR-1224-3p, circ-ZNF609/miR-1224-3p/PLK1 was shown responsible for circ-ZNF609 promoting glioma growth and metastasis. Yes Inhibition of circ-ZNF609 could obviously suppress glioma cell proliferation, migration and invasion, while overexpression of circ-ZNF609 promoted glioma growth and metastasis. In vivo, xenotransplanted tumor model also showed that overexpression of circ-ZNF609 could promote in vivo glioma growth. 33976745 ZNF609 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-623/FOXM1 Axis) Western Blot//Transfection//qRT-PCR//RIP//PCR//IP//IF circZNF609 abundance was enhanced in NSCLC tissues and cells. FOXM1 was targeted via miR-623 and regulated via circZNF609. miR-623 knockdown or FOXM1 overexpression mitigated the role of circZNF609 silence in NSCLC development. circZNF609 knockdown decreased NSCLC xenograft tumor growth. High expression of circZNF609 indicated the lower overall survival. Yes circZNF609 interference restrained cell viability, migration and invasion and increased apoptosis. miR-623 was targeted via circZNF609. circZNF609 knockdown decreased NSCLC xenograft tumor growth. 33574702 circHIPK3 CircRNA Rattus norvegicus Intestinal Mucosa Intestinal mucosal tissues Expression(lower expressed) IHC Intestinal mucosa from patients with inflammatory bowel diseases and sepsis had reduced levels of circHIPK3. Increasing the levels of circHIPK3 enhanced intestinal epithelium repair after wounding, whereas circHIPK3 silencing repressed epithelial recovery. CircHIPK3 silencing also inhibited growth of IECs and intestinal organoids, and circHIPK3 overexpression promoted intestinal epithelium renewal in mice. Mechanistic studies revealed that circHIPK3 directly bound to miR-29b and inhibited miR-29 activity, thus increasing expression of Rac1, Cdc42, and cyclin B1 in IECs after wounding. Yes CircHIPK3 silencing also inhibited growth of IECs and intestinal organoids, and circHIPK3 overexpression promoted intestinal epithelium renewal in mice. 34116030 ZNF667-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction( miR-18b-5p/RASA1 ) CCK8//qRT-PCR//Transwell Assay lncRNA ZNF667-AS1 was underexpressed in ESCC tissues and cells, and lncRNA ZNF667-AS1 overexpression hampered ESCC cell proliferation and invasiveness.miR-18b-5p targeted RASA1 while lncRNA ZNF667-AS1 promoted RASA1 transcription via binding to miR-18b-5p. Over-expression miR-18b-5p or silencing RASA1 reversed the inhibitory effects of lncRNA ZNF667-AS1 overexpression on ESCC cell proliferation and invasion. Yes lncRNA ZNF667-AS1 was underexpressed in ESCC tissues and cells, and lncRNA ZNF667-AS1 overexpression hampered ESCC cell proliferation and invasiveness. 35997118 ZNF710-AS1-202 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues regulation[ZNF710 expression] CCK8//qRT-PCR//Colony Formation Assay//Flow Cytometry The results revealed that ZNF710?AS1?202 was downregulated in human ccRCC tissues and was associated with the pathological grade, tumor size, local invasion and TNM stage, but not with lymph node metastasis or distant metastasis. In conclusion, the present study revealed that ZNF710‑AS1‑202 and ZNF710 may serve as promising therapeutic targets for ccRCC. The results revealed that ZNF710?AS1?202 was downregulated in human ccRCC tissues and was associated with the pathological grade, tumor size, local invasion and TNM stage, but not with lymph node metastasis or distant metastasis. Yes However, ZNF710?AS1?202 overexpression promoted the proliferation of RCC cells and inhibited apoptosis. Opposite results were observed when ZNF710?AS1?202 was knocked down by small interfering RNA. 32236626 ZNF674-AS1 LncRNA Homo sapiens Thyroid Neoplasms TC tissues and cells Interaction(miR-181a/SOCS4 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//H&E Staining//Cell Proliferation Assay//IHC//Invasion Assay//Transwell Assay ZNF674-AS1 and SOCS4 expression were remarkably reduced while miR-181a was upregulated in TC tissues and cells. . Mechanistic assays verified that ZNF674-AS1 directly interacted with miR-181a to increase SOCS4 expression. In addition, miR-181a overexpression aggravated proliferation, metastasis and EMT by inhibiting SOCS4. Interestingly, inhibition of miR-181a diminished the promoting effects of ZNF674-AS1 silencing on the malignant behaviours of TC cells. Yes Enforced expression of ZNF674-AS1 inhibited proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in vitro and reduced tumour growth in vivo. 34990740 ZNF674-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular liver cancer cell lines and tissues Expression(lower expressed) Western Blot//Transfection//qPCR//CCK8//Colony Formation Assay//Invasion Assay//Transwell Assay The lncRNA ZNF674-AS1 was undesirably expressed in liver cancer cell lines and tissues. Cell function assessments showed that compared with the blank control group (vector), overexpression of lncRNA ZNF674-AS1 could substantially hinder the proliferation, colony formation, migration, and invasion capability of liver cancer cells. Furthermore, overexpression of lncRNA ZNF674-AS1 could inhibit cell glycolysis (inhibit glucose consumption and reduce intracellular lactate and ATP levels) by inhibiting the expression of key proteins (such as PFKL, HK2, PKM2, and GLUT1) in the process of glycolysis. Yes Cell function assessments showed that compared with the blank control group (vector), overexpression of lncRNA ZNF674-AS1 could substantially hinder the proliferation, colony formation, migration, and invasion capability of liver cancer cells. 35874626 ZNF674-AS1 LncRNA Homo sapiens Lung Neoplasms NSCLC tissues and cells Interaction( miR-23a/E-cadherin axis) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay ZNF674-AS1 was downregulated in NSCLC tissues and cells, and inhibited the migration and invasion of NSCLC cells in vitro. We found that miR-23a could antagonize the role of ZNF674-AS1 in NSCLC. E-cadherin was identified as a downstream target gene of miR-23a, and miR-23a could directly inhibit its expression. Yes ZNF674-AS1 was downregulated in NSCLC tissues and cells, and inhibited the migration and invasion of NSCLC cells in vitro. In contrast, the expression of miR-23a, a downstream target of ZNF674-AS1, was increased in NSCLC tissues and cells. 35116709 ZNF667-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer cells and gastric cancer biopsies Expression(lower expressed) qRT-PCR//MTT//Colony Formation Assay//Western Blot It was found that lncRNA ZNF667-AS1 was downregulated in gastric cancer biopsies. Molecular mechanism studies displayed that the high level of lncRNA ZNF667-AS1 promoted the expression of E-cadherin and inhibited the expression of N-cadherin and VEGFA, leading to the inhibition of the proliferation, migration, and angiogenesis of gastric cancer cells. Yes Overexpression of ZNF667-AS1 reduced the propagation, migration, and angiogenesis of gastric cancer cells. 35813862 ZNF667-AS1 LncRNA Homo sapiens Breast Neoplasms BCa tissues and cell lines Interaction(FGF1) Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay MORT was downregulated in BCa tissues and cell lines. MORT could negatively regulate its target gene FGF1, which was responsible for the anti-cancer role of MORT in BCa progression. Low level of MORT predicted higher rate of distant metastasis in BCa patients. Yes Overexpression of MORT in SKBR-3 cells reduced proliferative and migratory rates, while knockdown of MORT in MCF-7 enhanced them. Moreover, in vivo overexpression of MORT slowed down tumor growth of BCa in nude mice. 34730198 ZNF667-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma esophageal cancer cells and ESCC tissues Expression[lower expressed] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay//ChIP Frequent downregulation of ZNF667-AS1 and ZNF667 was detected in esophageal cancer cells and ESCC tissues. Yes Overexpression of ZNF667-AS1 and ZNF667 suppressed the viability, migration, and invasion of esophageal cancer cells in vitro. 31804468 ZNF667-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Interaction(miR-1290/PRUNE2 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//IHC//Transwell Assay We found a decline in ZNF667-AS1 expression in ESCC tissues and cell lines. ZNF667-AS1 reduced miR-1290 to result in upregulation of the miR-1290 target gene PRUNE2. The inhibiting property of ZNF667-AS1 on the malignant characteristics of ESCC cells was achieved by disrupting the miR-1290-mediated downregulation of PRUNE2. ZNF667-AS1 overexpression indicated a favorable prognosis of ESCC sufferers. Yes ZNF667-AS1 suppressed the tumorigenesis of ESCC in vivo. ZNF667-AS1 overexpression suppressed ESCC cell malignant potentials. 35504176 ZNF667-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues Regulation(ANK2/JAK2 expression) qRT-PCR Key lncRNAs, including ZNF667-AS1, and their corresponding genes, such as ankyrin 2 (ANK2), were downregulated in CRC tumor tissues. Moreover, Janus kinase 2 (JAK2) and ANK2 were significantly down- and upregulated in the overexpressed ZNF667-AS1 VOLO cells compared to those in the negative-control group. Knockdown of ANK2 or overexpression of JAK2 significantly counteracted the inhibitory effects of overexpression of ZNF667-AS1 on LOVO cell proliferation and migration. In addition, downregulated ZNF667-AS1 (NR_036521.1) expression is associated with poor prognosis and disease progression. Yes Overexpression of ZNF667-AS1 (NR_036521.1) inhibited the proliferation, migration, and invasion of VOLO cells both in vitro and in vivo. 32853419 ZNF667-AS1 LncRNA Homo sapiens Arthritis, Rheumatoid Synovial tissues and FLSs Interaction(miR-523-3p and JAK/STAT signalling pathway) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA ZNF667-AS1 was downregulated in RA-FLSs and LPS-stimulated chondrocytes. ZNF667-AS1 overexpression significantly promoted cell proliferation and inhibited the production of IL-6, IL-17 and TNF-α in LPS-stimulated chondrocytes. Additionally, ZNF667-AS1 overexpression reduced the generation of CD4 + IL-17+ cells. In mechanism, ZNF667-AS1 acted a sponge for miR-523-3p. MiR-523-3p overexpression reversed the ZNF667-AS1-mediated regulation of cell proliferation and inflammation. Furthermore, miR-523-3p overexpression abolished the inhibitory effects of ZNF667-AS1 on the JAK/STAT signalling activation. Yes ZNF667-AS1 overexpression significantly promoted cell proliferation and inhibited the production of IL-6, IL-17 and TNF-α in LPS-stimulated chondrocytes. Additionally, ZNF667-AS1 overexpression reduced the generation of CD4 + IL-17+ cells. In mechanism, ZNF667-AS1 acted a sponge for miR-523-3p. 34423698 ZNF667-AS1 LncRNA Homo sapiens Colonic Neoplasms CC tumor and adjacent healthy tissues Interaction[inactivating TGF-β1] qRT-PCR//Western Blot Compared with that in the healthy tissues, the expression of MORT was significantly decreased in the tumor samples.Therefore, it is postulated that MORT inhibits invasion and migration colon cancer cells by inactivating TGF-β1. Yes Moreover, the overexpression of MORT resulted in decreased, whereas treatment with transforming growth factor β1 (TGF-β1) resulted in increased, invasion and migration rates of colon cancer cells. 31966041 ZNF667-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC patients Regulation(NOTCH1) qRT-PCR//Western Blot In our study, MORT expression was downregulated in hepatocellular carcinoma (HCC), while NOTCH1 expression was upregulated in HCC patients. Hepatitis B virus and hepatitis C virus infection and tumor size did not significantly affect MORT expression, but MORT expression was lower in metastatic HCC patients compared with nonmetastatic HCC patients. Yes MORT overexpression inhibited the migration and invasion of HCC cells, while NOTCH1 overexpression promoted the migration and invasion of HCC cells. In addition, NOTCH1 overexpression attenuated the effects of MORT overexpression on cell migration and invasion. 33493420 ZNF667-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms Bladder Cancer tissues regulation[MicroRNA-146a-5p] CCK8//qRT-PCR//Transwell Assay We found that miR-146a-5p was upregulated, while lncRNA MORT was downregulated in bladder cancer. lncRNA MORT may regulate bladder cancer cell behaviors by downregulating miR-146a-5p. Yes Overexpression of miR-146a-5p promoted, while overexpression of lncRNA MORT inhibited the invasion, migration, and proliferation of cells of bladder cancer cell lines. 32554962 ZNF667-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Interaction[downregulating ROCK1 ] qRT-PCR In the present study, we found that lncRNA MORT was downregulated, while rho-associated coiled-coil containing protein kinase 1 (ROCK1) messenger RNA was upregulated in cancer tissues than in adjacent healthy tissues of OSCC patients.ROCK1 overexpression led to significantly promoted cell proliferation but showed no significant effect on MORT expression. In addition, ROCK1 overexpression attenuated the inhibitory effects of lncRNA MORT overexpression on the proliferation of OSCC cells. Therefore, lncRNA MORT overexpression may inhibit cancer cell proliferation in OSCC cells by downregulating ROCK1. Follow-up study showed that low MORT level was significantly correlated with poor survival. Yes Overexpression of lncRNA MORT inhibited the proliferation of OSCC cells and downregulated ROCK1. 30805944 ZNF667-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow regulation[miR-206/AKAP13 axis] qRT-PCR The expression of ZNF667-AS1 was upregulated in AML patients, which predicted poor prognosis. ZNF667-AS1 potentiated AML progression by targeting the miR-206/AKAP13 axis. Yes Downregulation of ZNF667-AS1 reduced cell proliferation, invasion, tumorigenesis and metastasis. 33380835 ZNF667-AS1 LncRNA Homo sapiens ovarian carcinoma ovarian cancer tissues Interaction[downregulating miRNA-21] CCK8//qRT-PCR In the present study, we found that miRNA-21 was upregulated, while long noncoding RNA Mortal Obligate RNA Transcript (lncRNA MORT), which has been reported to be silenced in 16 types of cancers, was downregulated in tumor tissues than in adjacent healthy tissues of patients with ovarian carcinoma. Expression of lncRNA MORT in tumor tissues was found to be significantly affected by tumor size but not by tumor metastasis. Yes Overexpression of lncRNA MORT inhibited, while miRNA-21 overexpression promoted the proliferation of cells of ovarian cancer cell lines. 30916806 ZNF667-AS1 LncRNA Homo sapiens prostate carcinoma Tumor and adjacent healthy tissue Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Western Blot Compared with adjacent healthy tissues, expression levels of lncRNA MORT were significantly Expression[down-expression]regulated in tumor tissues. Compared with the control and negative control groExpression[Expression[up-expression]-expression]s, lncRNA MORT overexpression resulted in significantly reduced glucose Expression[Expression[up-expression]-expression]take (Fig. 3A) and inhibited GLUT-1 expression (Fig. 3B) (P<0.05). There were 18 patients with a primary tumor of 0–2 cm, 20 cases between 2–4 cm and 22 cases >4 cm. A decrease in the level of lncRNA MORT expression was associated with an increase in tumor size (Fig. 2B; P<0.05). Yes Compared with the control and negative control groExpression[Expression[up-expression]-expression]s, lncRNA MORT overexpression resulted in significantly reduced glucose Expression[Expression[up-expression]-expression]take (Fig. 3A) and inhibited GLUT-1 expression (Fig. 3B) (P<0.05). 31516590 ZNF667-AS1 LncRNA Homo sapiens Lymphoma, Mantle-Cell plasma regulation[Upregulating miRNA-16] qRT-PCR In this study, MORT and miRNA-16 were both downregulated in plasma of mantle cell lymphoma (MCL) patients than that in the controls. Yes The low levels of MORT and miRNA-16 were correlated with poor survival of MCL patients. 32280273 ZNF407-AS1 LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[LINC00909/miR-194/MUC1-C axis] Western Blot//qRT-PCR//FISH//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In the present study, we identified that LINC00909 expression was significantly elevated in glioma tissues and cell lines. Collectively, these data demonstrated that LINC00909/miR-194/MUC1-C axis regulated glioma progression and might act as a novel therapeutic target. High LINC00909 expression was associated with advanced WHO grade, high Karnofsky Performance Score (KPS), and poor prognosis in patients with glioma. Yes Function assays showed that LINC00909 depletion inhibited glioma cells proliferation, invasion in vitro and reduced tumor growth in vivo. 31132669 hsa_circ_0054633 CircRNA Rattus norvegicus Acute Lung Injury LPS-treated rat and MPVECs Regulation( NF-κB signaling pathway) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Cell Apoptosis Assay//ELISA circ_0054633, IL-17A, TNF-α and NF-κB p65 were all overexpressed in LPS-treated rat and MPVECs, and LPS enhanced the proliferation and apoptosis of MPVECs. Yes circ_0054633, IL-17A, TNF-α and NF-κB p65 were all overexpressed in LPS-treated rat and MPVECs, and LPS enhanced the proliferation and apoptosis of MPVECs. While circ_0054633 silencing reversed the above promotion effects of LPS on IL-17A, TNF-α expression and MPVECs proliferation and apoptosis. 32950633 ZFHX4-AS1 LncRNA Homo sapiens Breast Neoplasms Breast cancer tissues and adjacent tissues Regulation[ Hippo signaling pathway ] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Microarray//Transwell Assay The results (Fig. 1b)showed that the expression of lncRNA ZFHX4-AS1 was elevated in breast cancer tissues in comparison with adjacent tissues .In conclusion, our findings reveal that lncRNA ZFHX4-AS1 silencing exerts an inhibitory effect on breast cancer development by suppressing the activation of the Hippo signaling pathway via FAT4. Yes In addition, knockdown of lncRNA ZFHX4-AS1 suppressed breast cancer cell proliferation, migration, and invasion as well as tumor growth, blocked cell cycle entry, while promoted cell apoptosis by inhibiting the Hippo signaling pathway. 30546116 ZFPM2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular tumor tissues Interaction(miR‑3065‑5p/XRCC4 ) qRT-PCR ZFPM2‑AS1 was significantly upregulated in tumor tissues (P<0.001) and it promoted DNA damage repair (P<0.01) and tumor progression in vitro and in vivo. Luciferase reporter assays demonstrated that miR‑3065‑5p was able to bind directly with ZFPM2‑AS1 and X‑ray repair cross complementing 4 (XRCC4). ZFPM2‑AS1 upregulated XRCC4 expression by acting as a sponge (P<0.001). Yes ZFPM2‑AS1 was significantly upregulated in tumor tissues (P<0.001) and it promoted DNA damage repair (P<0.01) and tumor progression in vitro and in vivo. 36524359 ZFPM2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines regulation[ miR-137/TRIM24 axis] qRT-PCR//Luciferase Report Assay//RIP//Western Blot The expression levels of ZFPM2?AS1 were significantly upregulated in tissue samples from patients with CRC and CRC cell lines compared with normal tissue and normal human colorectal mucosa cell line.In conclusion, the present study indicated that ZFPM2‑AS1 may serve as an oncogene in CRC by regulating the miR‑137/TRIM24 axis. Notably, the upregulation of ZFPM2?AS1 was significantly associated with tumor size, histological differentiation, lymph node metastasis and TNM stage. Yes In addition, ZFPM2?AS1 knockdown significantly inhibited cell proliferation, migration and invasion compared with the control group in vitro. 33300060 ZFPM2-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cells Interaction(miR-130a-3p/ESCO2) In Vivo Experiment//qRT-PCR//ELISA//IHC//Bioinformatics Analysis We found that the expressions of ZFPM2-AS1 and ESCO2 were upregulated in RCC tissues and cells, whereas miR-130a-3p was downregulated. ZFPM2-AS1 interacted with miR-130A-3P and negatively regulated its expression in RCC cells. We further showed that ESCO2 was a downstream target of miR-130a-3p. Both miR-130a-3p inhibitor and ESCO2 overexpression could rescue the inhibitory effects of ZFPM2-AS1 knockdown in RCC cells. The expression level of ZFPM2-AS1 is significantly associated with advanced TNM, distant metastasis, lymphatic metastasis, and a poor overall survival in RCC patients. Yes Silencing ZFPM2-AS1 in RCC cells suppressed cell proliferation, invasion, and migration, and induced cell apoptosis. 35258173 ZFPM2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[ZFPM2-AS1/miR-139/GDF10] qRT-PCR//Luciferase Report Assay//Western Blot The expression level of lncRNA ZFPM2-AS1 was significantly higher in HCC tissues than in adjacent normal tissues, and higher ZFPM2-AS1 was remarkably related to poor survival.Our study provides new insight into the posttranscriptional regulation mechanism of lncRNA ZFPM2-AS1 and suggests that ZFPM2-AS1/miR-139/GDF10 may act as a potential therapeutic target and prognostic biomarker for HCC. The expression level of lncRNA ZFPM2-AS1 was significantly higher in HCC tissues than in adjacent normal tissues, and higher ZFPM2-AS1 was remarkably related to poor survival. Yes Functionally, silencing of lncRNA ZFPM2-AS1 inhibited cell proliferation, migration, invasion and promoted cell apoptosis in vitro. 32795316 ZFPM2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[ miR-1226/ITGB1 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining ZFPM2-AS1 was overexpressed in HCC tissues and cell lines.ZFPM2-AS1 promotes cell proliferation and migration by regulating miR-1226-3p/ITGB1 axis in HCC. High levels of ZFPM2-AS1 were correlated with advanced TNM stage, distant metastasis and a poorer overall survival rate. Yes ZFPM2-AS1 knockdown inhibited cell proliferation and invasion. 32744687 hsa_circ_0005075 CircRNA Rattus norvegicus Neuralgia CCI rat models Interaction(miR-151a-3p/NOTCH2 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//ELISA In our present study, we observed circ_0005075 was obviously increased in CCI rat models. To sum up, we indicated that loss ofcirc_0005075relieved neuropathic pain progression by inducement of miR-151a-3p and inactivation of NOTCH2 signaling. Yes Knockdown of circ_0005075 repressed thebehaviors of neuropathic pain including mechanical and thermal hyperalgesia. Moreover, loss of circ_0005075 could repress the neuroinflammation via targeting COX-2, IL-6 and TNF-α whereas inducing IL-10 in vivo. 32860901 ZFPM2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction( miR-653/GOLM1 axis) CCK8//qRT-PCR//Western Blot In this study, we identified ZFPM2-AS1 as a novel HCC-related lncRNA, which was observed to be distinctly upregulated in HCC tissues and associated with shorter overall survival.Luciferase reporter and chromatin immunoprecipitation assays suggested that overexpression of ZFPM2-AS1 was induced by STAT1. Mechanistic studies showed that there were two binding sites of miR-653 within the sequence of ZFPM2-AS1 and the levels of ZFPM2-AS1 were negatively correlated with miR-653. In addition, ZFPM2-AS1 could reverse the suppressor effects of miR-653 on the proliferation and metastasis of HCC cells by the modulation of GOLM1, a target gene of miR-653. In this study, we identified ZFPM2-AS1 as a novel HCC-related lncRNA, which was observed to be distinctly upregulated in HCC tissues and associated with shorter overall survival. Yes Functional investigations suggested that the inhibition of ZFPM2-AS1 suppressed cell proliferation, metastasis, cell cycle progression while accelerated cell apoptosis. 33414427 ZFPM2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-576-3p/HIF-1α axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Transwell Assay The expression of ZFPM2-AS1 in HCC tissues, compared with that in normal liver tissues, was significantly upregulated.miR-576-3p could reverse the effects of ZFPM2-AS1 on the biological behaviors of HCC cells. Besides, ZFPM2-AS1 could bind to miR-576-3p and positively regulate the expression of HIF-1α, a target gene of miR-576-3p, by adsorbing miR-576-3p. ZFPM2-AS1 is abnormally highly expressed in HCC and facilitates proliferation, migration, and invasion of HCC cells by adsorbing miR-576-3p and upregulating HIF-1α expression. Yes Knockdown of ZFPM2-AS1 markedly inhibited HCC cell proliferation, migration, and invasion while the overexpression of ZFPM2-AS1 worked oppositely. 34102651 ZFPM2-AS1 LncRNA Homo sapiens Glioma glioma cells Interaction(SP1/ZFPM2-AS1/miR-515-5p/SOD2 axis) In Vivo Experiment//RNA Pull-Down//IHC//Transfection//Tunel//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//ChIP we found that SP1 interacted with ZFPM2-AS1 promoter to transcriptionally activate ZFPM2-AS1 expression. Moreover, ZFPM2-AS1 was identified as a competing endogenous RNA (ceRNA) for miR-515-5p to target SOD2. Rescue assays verified that SOD2 overexpression partially abolished the suppressive impact of ZFPM2-AS1 silencing on glioma cell growth. Yes he effect of ZFPM2-AS1 on tumor growth was verified by in vivo assay.ZFPM2-AS1 silencing suppressed cell proliferation and cell cycle, but facilitated cell apoptosis. 34077295 ZFPM2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC specimens and cell lines regulation[ JAK-STAT and AKT pathways] Wound Healing Assay//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay We found that ZFPM2-AS1 expression in NSCLC specimens and cell lines was elevated compared to the control group. Our study confirmed that ZFPM2-AS1 promotes the proliferation, migration, and invasion of NSCLC cells via the JAK-STAT and AKT pathways. ZFPM2-AS1 is an oncogene and independent prognostic predictor of poor survival in NSCLCs, and its expression had a positive correlation with tumor size and lymph node metastasis in our clinical data. Yes MTT, colony forming, wound healing, and transwell assays showed a positive correlation between ZFPM2-AS1 expression and the proliferation, migration, and invasion of NSCLC cells in the presence and absence of interferon- (IFN-γ). 33173620 ZFPM2-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC samples and cells Regulation(miR-3612/DTL signaling) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Colony Formation Assay ZFPM2-AS1 showed upregulated expression in NPC samples and cells. ZFPM2-AS1 targeted miR-3612 whose expression was decreased in NPC samples and cells. Repression of miR-3612 aggravated NPC cell development and largely reversed the functional role of ZFPM2-AS1 silencing on NPC cell growth. MiR-3612 directly interacted with DTL, and DTL expression was upregulated in NPC. Downregulation of DTL blocked NPC cell growth, while miR-3612 inhibition partly abrogated the effects of DTL knockdown. ZFPM2-AS1 knockdown considerably restrained NPC development via targeting the miR-3612/DTL signaling. Yes Meanwhile, ZFPM2-AS1 was mainly located in the cytoplasm. Knockdown of ZFPM2-AS1 restrained NPC cell proliferation and induced apoptosis, as well as suppressed tumorigenesis in animal models. 35276693 ZFPM2-AS1 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues as well as cells Interaction(miR-515-5p/TUSC3) Transfection//CCK8//qRT-PCR//Colony Formation Assay//ChIP ZFPM2-AS1 and TUSC were both highly expressed and miR-515-5p was down-regulated in thyroid cancer tissues as well as cells. Mechanistically, up-regulation of ZFPM2-AS1 was induced by transcription factor STAT1 in line with CHIP and luciferase reporter assays. Furthermore, as a sponge of miR-515-5p, ZFPM2-AS1 decreased the ability of miR-515-5p to inhibit TUSC3 expression by pull-down, luciferase reporter and gain-and-loss assays, thereby promoting malignant progression of thyroid cancer. Yes Their knockdown weakened thyroid cancer cell growth, migration, and invasion. 33976749 ZFPM2-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Regulation[miR-18b-5p/VMA21 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay Also, ZFPM2-AS1 was detected to be overexpressed in LUAD tissues and cells.Therefore, ZFPM2-AS1 were confirmed to regulate VMA21 by competitively binding with miR-18b-5p. Finally, rescue assays confirmed that ZFPM2-AS1 could regulate LUAD cell proliferation via miR-18b-5p/VMA21 axis. Yes Furthermore, ZFPM2-AS1 could promote the proliferation of LUAD cells. 31297866 ZFPM2-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung cell lines regulation[ ZFPM2-AS1-UPF1-ZFPM2 axis ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//cell invasion assay We showed that ZFPM2-AS1 expression is high in LUAD samples based on GEPIA database (http://gepia.cancer-pku.cn/) and validated ZFPM2-AS1 upregulation in LUAD cell lines. Taken together, our findings demonstrate a role for the ZFPM2-AS1-UPF1-ZFPM2 axis in LUAD progression, suggesting ZFPM2-AS1 as a new potential target for LUAD treatment. Yes Functionally, ZFPM2-AS1 facilitated proliferation, invasion, and epithelial-to-mesenchymal transition of LUAD cells. 31919993 ZFPM2-AS1 LncRNA Homo sapiens Retinoblastoma RB tissues and cell lines regulation[MicroRNA-515/HOXA1/Wnt/β-Catenin Axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay ZFPM2-AS1 was significantly overexpressed in RB tissues and cell lines, and ZFPM2-AS1 silencing curtailed the growth and metastasis of RB cells both in vitro and in vivo. Altogether, these data demonstrated that ZFPM2-AS1 interacted with HOXA1 to promote RB development via mediating miR-515, establishing a promising therapeutic biomarker for RB and prognosis. Yes ZFPM2-AS1 was significantly overexpressed in RB tissues and cell lines, and ZFPM2-AS1 silencing curtailed the growth and metastasis of RB cells both in vitro and in vivo. 32561925 ZFPM2-AS1 LncRNA Homo sapiens Retinoblastoma retinoblastoma cell and tissues Interaction(ZFPM2-AS1/511-3p/PAX6 axis) qRT-PCR//Luciferase Report Assay//migration assay//Western Blot Our study found that ZFPM2-AS1 and PAX6 were upregulated, whereas miR-511-3p was downregulated in retinoblastoma.We also found that ZFPM2-AS1 targets miR-511-3p to upregulate PAX6 in Y79 and SO-RB50 cells. Moreover, we demonstrated that inhibiting miR-511-3p reversed the negative effects of silencing ZFPM2-AS1 and PAX6 on retinoblastoma cell viability and migration. In conclusion, retinoblastoma development is regulated by the ZFPM2-AS1/511-3p/PAX6 axis. Yes ZFPM2-AS1 inhibition decreased the viability and migration of retinoblastoma cells. 34989314 ZFPM2-AS1 LncRNA Homo sapiens Retinoblastoma RB cells and tissues Interaction(miR-3612/NT5E Signaling Axis) RNA Pull-Down//CCK8//RIP//ELISA//Transwell Assay These results suggest that by targeting the miR-3612/NT5E axis, ZFPM2-AS1 stimulates the proliferation and migration of RB cells, while inhibiting their apoptosis. Therefore, ZFPM2-AS1 may be a promising therapeutic target associated with RB development. Yes Overexpression of ZFPM2-AS1 and NT5E and downregulation of miR-3612 expression levels were observed in RB cells and tissues. Knockdown of ZFPM2-AS1 decreased the proliferation and migration of RB cells, while enhancing their apoptosis. 35997119 ZFPM2-AS1 LncRNA Homo sapiens Small Cell Lung Carcinoma SCLC tissues and cells regulation[TRAF4] RNA Pull-Down//ChIP//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay ZFPM2-AS1 was significantly upregulated in SCLC tissues and cells. Finally, TRAF4 could countervail ZFPM2-AS1 downregulation-mediated function on SCLC cell proliferation and invasion in vitro and tumor growth in vivo. Yes ZFPM2-AS1 deficiency attenuated SCLC cell proliferation, invasion and migration. 32280300 ZFPM2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cells regulation[up-regulating TRAF4,NF-κB pathway] qRT-PCR//Luciferase Report Assay//RNA Pull-Down The present study indicated that ZFPM2-AS1 was significantly up-regulated in ESCC cells. Collectively, all the results suggested that ZFPM2-AS1 was an oncogene in ESCC cell growth by up-regulating TRAF4 and activating NF-κB pathway. Yes Functional assays manifested that ZFPM2-AS1 knockdown restrained cell proliferation, migration and invasion, and facilitated cell apoptosis in ESCC. 32065218 ZFPM2-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues regulation[upregulating JMJD6] IHC//Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The results showed that ZFPM2-AS1 was upregulated in BC tissues, LncRNA ZFPM2-AS1 is upregulated in BC and linked to tumor stage, metastasis, and prognosis in BC patients. It aggravates the malignant development of BC via upregulating JMJD6. The results showed that ZFPM2-AS1 was upregulated in BC tissues, and its high level was linked to advanced tumor stage, high rates of lymphatic metastasis, and distant metastasis, as well as poor prognosis in BC. Yes The knockdown of ZFPM2-AS1 suppressed proliferative and migratory abilities in BC cells. In vivo knockdown of ZFPM2-AS1 in nude mice bearing BC showed a smaller tumor volume and lower tumor weight than controls. 33215431 ZNF292 CircRNA Homo sapiens Carcinoma, Hepatocellular regulation[Wnt/β-catenin pathway] TUNEL//Western Blot//Tunel//qRT-PCR//PCR Besides, in Huh-7 cells with circRNA ZNF292 knockdown, the expressions of Axin, β-catenin, phosphorylated signal transducer and activator of transcription 3 (p-STAT3), p-STAT5, Cyclin A and Cyclin-dependent kinase 2 (CDK2) were down-regulated, while the expressions of STAT3 and STAT5 did not change remarkably. Yes Compared with those in siRNA-normal control (NC) group, the proliferation of Huh-7 cells was significantly inhibited and their cloning ability was remarkably weakened (p<0.05), the proportion of cells in S phase was decreased while that in G1 phase was increased (p<0.05), the apoptosis rate of Huh-7 cells was higher and the number of apoptosis was larger in siRNA-2# knockdown group (p<0.05). 33336730 ZNF204P LncRNA Homo sapiens Carcinoma, Hepatocellular Cancer stem cell Interaction( miRNA-145-5p/OCT4, SOX2 axis) Wound Healing Assay//Migration Assay//qRT-PCR//Cell Viability Assay//Colony Formation Assay//Invasion Assay As the cytosolic ZNF204P shares miRNA binding sites with OCT4 and SOX2, well-known drivers of pluripotency and self-renewal, we propose that ZNF204P promotes tumorigenesis through the miRNA-145-5p/OCT4, SOX2 axis. Yes ZNF204P knockdown impairs cell proliferation and migration/invasion. 35168700 ZNF281 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues regulation[microRNA-124] qRT-PCR//Transwell Assay The present study revealed that lncRNA-ZNF281 was upregulated, and that microRNA (miR)-124 was downregulated, in cancerous tissues compared with that in the paired adjacent healthy tissues of patients with gastric cancer.Therefore, lncRNA-ZNF281 may promote cancer cell migration and invasion in gastric cancer via downregulation of miR-124. lncRNA-ZNF281 expression level was also associated with the clinical stage of the patient. Yes Subsequent in vitro cell experiments indicated that lncRNA-ZNF281 overexpression resulted in promoting the migration and invasiveness of gastric cancer cells, while miR-124 over-expression led to its inhibition. 32194679 ZNF281 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cancer tissues regulation[downregulation of microRNA-221] CCK8//qRT-PCR//Flow Cytometry In patients with NSCLC, expression levels of ZNF281 were significantly lower in cancer tissues compared with in non-cancerous tissues, and lower levels of ZNF281 expression in cancerous tissues predicted poor survival.Therefore, ZNF281 may upregulate PTEN via downregulation of miR-221 in NSCLC, resulting in inhibition of cancer cell proliferation and the promotion of apoptosis. In patients with NSCLC, expression levels of ZNF281 were significantly lower in cancer tissues compared with in non-cancerous tissues, and lower levels of ZNF281 expression in cancerous tissues predicted poor survival. Yes In addition, ZNF281 and PTEN overexpression resulted in accelerated cell apoptosis and inhibited the cell proliferation of NSCLC cells. 32782613 ZNF281 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues interaction[miR-539] qRT-PCR//Luciferase Report Assay//Transwell Assay The authors showed that ZNF281 was upregulated and miR-539 was downregulated in HCC tissues and were negatively correlated. Therefore, ZNF281 may interact with miR-539 to promote HCC cell invasion and migration. High levels of ZNF281 and low levels of miR-539 predicted the poor survival of HCC patients. Yes Overexpression analysis showed that ZNF281 and miR-539 overexpression led to the downregulation of each other. Transwell assays showed that ZNF281 overexpression led to enhanced and miR-539 overexpression led to suppressed HCC cell invasion and migration. 32073896 ZNF281 LncRNA Homo sapiens Osteosarcoma OS tissue regulation[upregulating miR-144] qRT-PCR//Transwell Assay//Western Blot The present study aimed to analyze the functionality of ZNF281 in osteosarcoma (OS). It was demonstrated that ZNF281 was downregulated in OS tissue specimens and predicted the survival of patients with OS. Thus, ZNF281 may downregulate ROCK1 by upregulating miR-144 and inhibit cancer cell invasion and migration in OS. The present study aimed to analyze the functionality of ZNF281 in osteosarcoma (OS). It was demonstrated that ZNF281 was downregulated in OS tissue specimens and predicted the survival of patients with OS. Yes Expression of ZNF281 and miR-144 resulted in decreased cell migration and invasion, while ROCK1 overexpression resulted in increased invasion and migration of OS cells. 32863912 ZNF281 LncRNA Homo sapiens Glioma glioma stem-like cells (U251s) Expression[lower expressed] qRT-PCR The expression of lncRNA-ZNF281 was lower in glioma stem-like cells (U251s) and this indicates that lncRNA-ZNF281 can regulate the self-renewal capacity of glioma stem-like cells and stem cell marker expression. Yes Our data demonstrates that lncRNA-ZNF281 inhibits the self-renewing ability and invasion of GSCs in vitro and in vivo and can reduce tumorigenicity in the glioma stem-like cell (U251s). 30509101 ZNF281 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical carcinoma tissues and cell lines Regulation(KLF15 ) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Migration Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay ZNF281 was upregulated in cervical carcinoma tissues and cell lines. KLF15 was the downstream gene binding ZNF281, and they were negatively correlated to each other in cervical carcinoma tissues. Notably, KLF15 was responsible for ZNF281-induced regulation on cervical carcinoma migration. It was correlated to TNM staging, and incidences of lymphatic metastasis and distant metastasis in cervical carcinoma patients, while it was unrelated to age and tumor size. Yes The knockdown of ZNF281 effectively attenuated migratory ability in HeLa and SiHa cells. Besides, knockdown of ZNF281 also reduced tumorigenicity of cervical carcinoma in nude mice. 34604953 ZNF24TR LncRNA Homo sapiens Pancreatic Neoplasms PC tissues Interaction(ATF3/ZNF24/VEGFA pathway) In Vivo Experiment//Northern Blot//Western Blot//Transfection//qRT-PCR//FISH//IHC Mechanistically, ZNFTR interacted with activating transcription factor 3 (ATF3) and sequestered ATF3 away from the ZNF24 promoter, which consequently increased the expression of ZNF24. Further, ZNF24 inhibited the proliferative, metastatic, and pro-angiogenic abilities of PC cells by suppressing transcription of vascular endothelial growth factor A (VEGFA). Therefore, the downregulation of ZNFTR in PC led to the decreased expression of ZNF24, which further resulted in the upregulation of VEGFA to facilitate the development of PC. Meanwhile, ZNFTR was transcriptionally inhibited by the HIF-1α/HDAC1 complex-mediated deacetylation. Clinical results further demonstrated that the low expression of ZNFTR was associated with poor overall survival time. Yes Functional role of lncRNA BM466146.1 on PC was evaluated by gain- and loss-of-function experiments in vivo and in vitro. RNA pull-down, RNA immunoprecipitation, luciferase reporter, and Chromatin-immunoprecipitation assays were performed to assess the mechanism of ZNFTR, respectively. The correlation between the expression of ZNFTR and various clinicopathological characteristics was accessed in PC specimens. This study displayed lncRNA BM466146.1 was downregulated in PC tissues and functioned as a suppressor through regulating the expression of adjacent gene Zinc finger protein 24 (ZNF24), which was assigned as ZNFTR. 34480024 ZNF205-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction[EGR4 ] RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//IHC//ChIP Herein, we reported the identification of a novel NSCLC-associated functional lncRNA ZNF205 antisense RNA 1 (ZNF205-AS1). ZNF205-AS1 was increased in NSCLC tissues and cell lines, and associated with poor prognosis of NSCLC patients. Collectively, our study demonstrated that the positive feedback loop between ZNF205-AS1 and EGR4 promotes NSCLC growth, and implied that targeting this feedback loop may be promising therapeutic strategy for NSCLC. Herein, we reported the identification of a novel NSCLC-associated functional lncRNA ZNF205 antisense RNA 1 (ZNF205-AS1). ZNF205-AS1 was increased in NSCLC tissues and cell lines, and associated with poor prognosis of NSCLC patients. Yes Gain-of-function and loss-of-function assays demonstrated that both ZNF205-AS1 and EGR4 promoted NSCLC cell growth in vitro and NSCLC tumour growth in vivo. 30556283 circSlc7a11 CircRNA Rattus norvegicus bone cancer spinal cords of BCP model rats Expression [highly expressed] Western Blot//qRT-PCR//RNA-seq//Cell Proliferation Assay//Bioinformatics Analysis Multiple circRNAs were differentially expressed in the spinal cords of BCP model rats; of these, circSlc7a11 showed the greatest increase in expression. Yes The overexpression of circSlc7a11 significantly promoted cell proliferation and repressed apoptosis of LLC-WRC 256 and UMR-106 cells, whereas circSlc7a11 silencing produced the opposite effects. 33433832 circITCH CircRNA Rattus norvegicus Diabetic Retinopathy RPEs Regulation(miR-22) In Vivo Experiment//qRT-PCR//Transfection//Western Blot As our results shown, the RNA expression of circ-ITCH was significantly lower in RPEs isolated from diabetic rats than they were in those isolated from normal rats. While diabetes induced an increase in MMP-2, MMP-9 and TNF-α in RPEs, circ-ITCH overexpression exerted an inhibitory on these increases and knockdown of circ-ITCH reversed the inhibitory. In addition, increased expression of miR-22 in RPEs correlated with diabetes and downregulation of circ-ITCH. Remarkably, in the presence of miR-22 mimics, the effects of circ-ITCH on the MMP-2 and MMP-9 were both antagonized. Collectively, our data supports a cellular signaling cascade in which circ-ITCH-inhibited miR-22 activity modulates the expression of MMP-2, MMP-9 and TNF-α in DR. Yes While diabetes induced an increase in MMP-2, MMP-9 and TNF-α in RPEs, circ-ITCH overexpression exerted an inhibitory on these increases and knockdown of circ-ITCH reversed the inhibitory. 33309614 circTYW1 CircRNA Rattus norvegicus Spinal Cord Injuries SCI and sham-operated rats Interaction(miR-380/FGF9/ERK1/2 axis) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Flow Cytometry//FISH//qRT-PCR//CCK8//IHC//EdU Staining By accessing the GEO repository, the expression of circTYW1, microRNA-380 (miR-380), and FGF9 in SCI and sham-operated rats was evaluated. In summary, our results demonstrated that declines in circTYW1 prevented SCI rats from neurological recovery by regulating the miR-380/FGF9/ERK1/2 axis, which might provide new understanding for SCI treatment. Yes circTYW1 promoted neurological recovery in SCI rats and inhibited apoptosis in spinal cord tissues. 34375168 circSirt1 CircRNA Rattus norvegicus Hypertension, Pulmonary PAH rat model Interaction(SIRT1/ TGF-β1/Smad3/Smad7) Transfection//Wound Healing Assay//Tunel//qRT-PCR//FISH//Luciferase Report Assay//Microarray We found that the expression of circ-Sirt1 and SIRT1 decreased in the PAH rat model induced by hypoxia. The findings of the present study indicate that circ-Sirt1 regulates the expression of SIRT1 mRNA and inhibits TGF-β1/Smad3/Smad7 mediated proliferation and migration of PASMC. Yes It was also revealed that the overexpression of circ-SIRT1 increased SIRT1 levels, but inhibited the expression of transforming growth factor (TGF)-β1, Smad3, and Smad7, and weakened PASMC cell vitality, proliferation, and migration ability. 35225027 ZMIZ1-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(PTBP1/ZMIZ1 ) qRT-PCR//RIP Compared to the controls, OS tissues and cells contained higher ZMIZ1-AS1 expression. Our findings further showed that ZMIZ1-AS1 recruits RNA-binding protein PTBP1 to stabilize ZMIZ1 mRNA. PTBP1 or ZMIZ1 overexpression rescues the suppressive effects of silenced ZMIZ1-AS1 on OS cellular processes Yes Silencing of ZMIZ1-AS1 repressed OS cell viability, proliferation, migration, and invasion. Importantly, ZMIZ1-AS1 promotes OS growth in vivo by stabilization of ZMIZ1. 34508303 ZKSCAN1 CircRNA Homo sapiens Urinary Bladder Neoplasms BC tissues regulation[PI3K/AKT pathway] qPCR//PCR//Western Blot Firstly, bioinformatics analyses indicated ZNF139 was upregulated in BC tissues and correlated with disease-free survival of BC patients. Collectively, this work reveals ZNF139 and circZNF139 cooperate closely with each other to promote cell proliferation, migration and invasion via activation of PI3K/AKT pathway in BC. Firstly, bioinformatics analyses indicated ZNF139 was upregulated in BC tissues and correlated with disease-free survival of BC patients. Yes Functionally, ZNF139/circZNF139 had facilitated effects on the proliferative, clonal, migratory, and invasive potential of BC cells. 32454461 circGTF2I CircRNA Rattus norvegicus Myocardial Reperfusion Injury MIRI rat model and cell model Interaction(miR-590-5p/KBTBD7) Transfection//Tunel//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//ELISA//EdU Staining Compared with that in the sham and control groups, circ-GTF2I expression in MIRI and the hypoxia/reoxygenation treatment model was significantly upregulated in vivo and in vitro. Further detection through the double-luciferase reporter assay confirmed that the binding site of circ-GTF2I to miR-590-5p and miR-590-5p was Kelch repeat and BTB domain-containing protein 7 (KBTBD7). Yes The knockdown of circ-GTF2I relieved neonatal rat cardiomyocyte damage and MI.ELISA and RT-qPCR results showed that circ-GTF2I induced the abnormal expressions of IL-6 TNF-α, LDH, Bax, Bcl-2, and Cyt-c in MIRI and the hypoxia/reoxygenation treatment models by regulating miR-590-5p and the heart development transcription factor KBTBD7. 35668777 ZFR CircRNA Homo sapiens Colorectal Neoplasms CC cell lines Interaction(miR-147a/CACUL1 axis) qRT-PCR//Tunel//Western Blot CircZFR was highly expressed in CC cell lines. The expression levels of miR-147a and CACUL1 were decreased and increased, respectively, in CC cells. These data demonstrated that circZFR could target miR-147a and CACUL1 to regulate the cell cycle and apoptosis of CC cells and, ultimately, promote the progression of CC. Yes CircZFR was highly expressed in CC cell lines. Interference with its expression inhibited proliferation and induced G1/S cell cycle arrest and apoptosis in CC cells. 36092343 ZFR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[upregulating MAP2K1] qRT-PCR//Luciferase Report Assay CircRNA ZFR was highly expressed in HCC species than the paracancerous ones. CircRNA ZFR is upregulated in HCC and closely linked to tumor grading. It promotes proliferative ability in HCC by upregulating MAP2K1. Higher level of circRNA ZFR predicted more advanced tumor grading of HCC Yes The knockdown of circRNA ZFR attenuated the proliferative ability of HCC cells, while the overexpression of circRNA ZFR obtained opposite results. 33090396 ZFR CircRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cell lines interaction[miR-545 and miR-1270] qRT-PCR//RNA Pull-Down//Luciferase Report Assay The expression of CircZFR was up-regulated both in BCa tissues and in BCa cell lines, and was positively correlated with patient survival rates. CircZFR promotes the proliferation, migration and invasion of BCa cells by upregulating WNT5A signaling pathway via sponging miR-545 and miR-1270. The expression of CircZFR was up-regulated both in BCa tissues and in BCa cell lines, and was positively correlated with patient survival rates. Yes Blocking of circZFR's expression by RNA inhibitors suppressed the proliferation, migration and invasion of BCa cells both in vitro and in vivo. 33928018 ZEB2-AS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues and cells regulation[microRNA-188/TAB3] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The expression of ZEB2-AS1 in colon cancer tissues and cells was significantly higher than that in normal ones, and ZEB2-AS1 was confirmed to be mostly located in the cytoplasm. It may be involved in the development of this cancer through the process of glycolysis regulated by microRNA-188/TAB3. Yes In addition, ZEB2-AS1 overexpression could enhance the cell proliferation rate and migration ability as well as reduce the cell apoptosis, which could be reversed by microRNA-188 overexpression. 32373954 ZEB2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-582-5p/FOXC1 Axis) qRT-PCR In HCC tissues and cells, ZEB2-AS1 expression was increased. It was also confirmed that ZEB2-AS1 could competitively bind with miR-582-5p to repress its expression, and indirectly up-regulate FOXC1 expression level in HCC cells. High ZEB2-AS1 expression was related to relatively large tumor volume, increased tumor-node-metastasis (TNM) stage and positive lymph node metastasis of the patients. Yes ZEB2-AS1 overexpression facilitated HCC cell multiplication, migration, invasion and suppressed apoptosis, while ZEB2-AS1 knock-down caused the opposite effects. 35892230 ZEB2-AS1 LncRNA Homo sapiens Osteosarcoma Osteosarcoma tissues Expression[highly expressed] qRT-PCR//Wound Healing Assay//Transwell Assay//Western Blot The results showed that ZEB2-AS1 expression levels were significantly upregulated in OS tissues, compared with adjacent normal tissues (Fig. 1A). Clinical association analysis revealed that high ZEB2-AS1 expression correlated with tumor size, distant metastasis and poor prognosis of OS patients. Yes Loss-of-function assays demonstrated that ZEB2-AS1 knockdown suppressed the proliferation and induced apoptosis in OS cells. In addition, ZEB2-AS1 knockdown inhibited cell migration, invasion, EMT of OS cells in vitro. 33085924 XIST LncRNA Homo sapiens Psoriasis psoriasis patients Interaction(miR-338-5p and IL-6 ) Transfection//CCK8//qRT-PCR//Luciferase Report Assay//ELISA Serum XIST was elevated in patients with psoriasis and can distinguish the psoriasis patients from healthy controls according to the receiver operating characteristic curve. XIST can sponge miR-338-5p, and miR-338-5p downregulation abolished the inhibitory effect of XIST silencing on cell proliferation and inflammation. miR-338-5p was highly expressed in the clinical serum samples from psoriasis patients. The target relationship between miR-338-5p and IL-6 was proved. Serum XIST was elevated in patients with psoriasis and can distinguish the psoriasis patients from healthy controls according to the receiver operating characteristic curve. A high level of XIST was positively correlated with the PASI score and serum tumor necrosis factor-alpha (TNF-α), interleukin-17A [IL-17A], and IL-22 concentrations in psoriasis patients. Yes A high level of XIST was positively correlated with the PASI score and serum tumor necrosis factor-alpha (TNF-α), interleukin-17A [IL-17A], and IL-22 concentrations in psoriasis patients. 35231918 XIST LncRNA Homo sapiens Retinoblastoma blood Interaction[LncRNA NKILA] CCK8//qRT-PCR We found that, comparing to healthy controls, NKILA was downregulated, while lncRNA XIST was upregulated in plasma of retinoblastoma patients and they were inversely correlated. Downregulation of NKILA distinguished early-stage patients from healthy controls. Overexpression of lncRNA NKILA mediated the downregulation of XIST in retinoblastoma cells, while XIST overexpression failed to significantly affect NKILA. Yes Overexpression of NKILA resulted in decreased, while XIST overexpression resulted in increased proliferation, migration and invasion rates of retinoblastoma cells. 30995132 XIST LncRNA Homo sapiens Retinoblastoma RB tissues and cells Interaction[sponging miR-101] qRT-PCR We found the expression of XIST, ZEB1 and ZEB2 was increased, whereas miR-101 was reduced in RB tissues and cells.In conclusion, these findings suggest that XIST may facilitate the progression of RB through acting as a ceRNA for miR-101 to mediate the expression of ZEB1 and ZEB2. Yes Knockdown of XIST significantly suppressed the proliferation, migration, invasion and EMT, but promoted the apoptosis and caspase-3 activity. 30472203 XIST LncRNA Homo sapiens Retinoblastoma RB tissues and cells regulation[miR-361-3p/STX17] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expression levels of XIST and STX17 were higher in RB tissues and cells, but miR-361-3p was downregulated. XIST functioned as an oncogenic lncRNA via miR-361-3p/STX17 axis in the progression of RB, which might provide a promising theoretical basis for the clinical therapy of RB. Yes Loss of XIST was inversely connected with aggressive characteristics, showing as the curb of cell proliferation, migration, invasion, autophagy, and enhancement of apoptosis in RB cells. Also, the deficiency of XIST caused the decrease of tumor growth in vivo. 33155266 XIST LncRNA Homo sapiens Retinoblastoma RB tissues regulation[miR-140-5p/SOX4 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In RB tissues, XIST and SOX4 expressions were obviously increased, but the miR-140-5p expression was markedly reduced. XIST expression was positively related to SOX4 expression while negatively correlated with miR-140-5p expression, and negative correlation was exhibited between miR-140-5p and SOX4 expression in RB tissues.XIST was obviously increased in RB tissues and cells, and XIST inhibition repressed the proliferation and invasion of RB cells by miR-140-5p/SOX4 axis, which may provide new understandings of the XIST molecular mechanism in RB. Yes XIST knockdown could impede RB cell proliferation and invasion, while miR-140-5p inhibition reversed the effects. 32127028 XIST LncRNA Homo sapiens tongue squamous cell carcinoma TSCC cell and tissues Interaction(miR-124/JAG1) Western Blot//Wound Healing Assay//CCK8//Luciferase Report Assay//ChIP-seq We found that lncRNA XIST was up-regulated in TSCC patients, and it facilitated the TSCC cell migration and proliferation in vitro. lncRNA XIST regulated miR-124 expression through ceRNA mechanism. Up-regulating miR-124 significantly inhibited TSCC cell migration and proliferation. JAG1 acted as immediate target of miR-124. Moreover, lncRNA XIST targeted miR-124 to regulate JAG1 levels through the ceRNA mechanism. Yes We found that lncRNA XIST was up-regulated in TSCC patients, and it facilitated the TSCC cell migration and proliferation in vitro. 35023687 XIST LncRNA Homo sapiens Liver Neoplasms human liver cancer tissues and paired normal adjacent liver tissues Interaction(miR-200b-3p ) Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Cell Proliferation Assay//Invasion Assay The lncRNA XIST was significantly upregulated in liver cancer, and increased lncRNA XIST expression was associated with a poor prognosis. The lncRNA XIST was significantly upregulated in liver cancer, and increased lncRNA XIST expression was associated with a poor prognosis. Yes The lncRNA XIST promoted liver cancer cell proliferation, migration, and invasion in vitro, and acted as a molecular sponge for miR-200b-3p, and also regulated the expression of ZEB1/2 via miR-200b-3p. 34018840 XIST LncRNA Homo sapiens Myocardial Infarction H9c2 cells Interaction(miR-486-5p/SIRT1 Axis) Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay Our findings revealed that hypoxia significantly downregulated the expressions of XIST. Moreover, XIST negatively regulated the expression of miR-4486-5p and upregulation of XIST inhibited hypoxic injury by downregulating miR-486-5p. Furthermore, SIRT1 expression was negatively regulated by miR-486-5p. We concluded that lncRNA XIST might provide protection against injury induced by hypoxia via miR-486-5p/SIRT1 axis. Yes Also, the cell viability markedly increased due to the overexpression of XIST in hypoxia-induced H9c2 cells, while overexpression of XIST significantly reduced the cell apoptosis in hypoxia-induced H9c2 cells. On the other hand, opposite effects were observed due to the downregulation of XIST in hypoxia-induced H9c2 cells. 36129595 XIST LncRNA Homo sapiens Neuroblastoma neuroblastoma tissues and cells lines Regulation[downregulated DKK1 ] RIP//qPCR//RNA Pull-Down//Western Blot XIST was significantly upregulated in neuroblastoma tissues (n = 30) and cells lines, and it was statistically associated with the age and International Neuroblastoma Staging System (INSS) staging in neuroblastoma patients. In conclusion, XIST downregulated DKK1 by inducing H3 histone methylation via EZH2, thereby facilitating the growth, migration and invasion of neuroblastoma cells and retarding tumor progression. Yes Downregulation of XIST suppressed the growth, migration and invasion of neuroblastoma cells. Downregulation of XIST increased DKK1 expression to suppress neuroblastoma cell growth, invasion, and migration, which markedly restrained the tumor progression. 31208278 XIST LncRNA Homo sapiens Pituitary Neoplasms PitNET tissues Interaction[increasing miR-424-5p] RNA Pull-Down//Western Blot//Wound Healing Assay//qPCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Microarray//IHC//EdU Staining//Transwell Assay Both XIST and bFGF exhibited high expression, but miR-424-5p had a low expression in invasive PitNET tissues as compared to non-invasive PitNET normal pituitary tissues. In conclusion, the fundamental findings of the present study suggested that the functional suppression of XIST downregulated bFGF to inhibit the development of PitNET by increasing miR-424-5p expression, proposing XIST as a novel therapeutic target for PitNET. Yes Furthermore, depleted XIST or bFGF, or elevated miR-424-5p was revealed to suppress the proliferation, migration, invasion, and promote cell cycle arrest and apoptosis of invasive PitNET cells. 31564894 XIST LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue and cell lines Interaction[miR-335/SOD2/ROS signal pathway] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//ELISA//Colony Formation Assay This study showed that LncRNA-XIST aberrantly overexpressed in either NSCLC tissues or cell lines comparing to their paired control groups. Mechanistically, miR-335 inhibitor reversed the effects of downregulated LncRNA-XIST on ROS levels and cell pyroptosis, which were abrogated by synergistically knocking down SOD2. Taken together, knock-down of LncRNA-XIST inhibited NSCLC progression by triggering miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death. Yes Knock-down of LncRNA-XIST promoted NSCLC cell apoptosis and inhibited cell proliferation, which were reversed by synergistically treating cells with pyroptosis inhibitor Necrosulfonamide (NSA). 31553952 XIST LncRNA Homo sapiens Wilms Tumor tumor and matched adjacent normal tissues and blood collected from 49 WT patients Interaction(miR-194-5p/YAP pathway) Western Blot//Transfection//Migration Assay//qRT-PCR//ChIP-seq We found that XIST lncRNA levels were increased in blood and tissue samples of WT patients, and this upregulation was significantly correlated with TNM staging and shorter survival time. Notably, we found that XIST upregulation correlated with miR-194-5p downregulation and YAP upregulation in WT tissues, suggesting that XIST regulates the miR-194-5p/YAP pathway. We found that XIST lncRNA levels were increased in blood and tissue samples of WT patients, and this upregulation was significantly correlated with TNM staging and shorter survival time. Yes Conversely, XIST downregulation inhibited WT cell proliferation, migration, and invasion and induced apoptosis. 33883934 XIST LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues Regulation[miR-124-EZH2 axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Quantitative real-time PCR (qRT-PCR) suggested that XIST was highly upregulated in laryngeal squamous cancerous (LSCC) tissues.Therefore, XIST plays an important role in progression of LSCC by modulating the miR-124-EZH2 axis. Yes Knockdown of XIST, mediated by lentiviral transfection of XIST-specific short-hairpin RNA (shRNA), led to the inhibition of proliferation, migration, and invasion of LSCC cells in vitro. In vivo, XIST knockdown also suppressed the growth of LSCC xenografts in mice. 31071316 XIST LncRNA Homo sapiens Carcinoma, Hepatocellular hepatic carcinoma tissues and cells Interaction(microRNA-320a/PIK3CA axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Transwell Assay lncRNA XIST was highly expressed in hepatic carcinoma tissues and cells. lncRNA XIST accelerates hepatic carcinoma progression by targeting the miR-320a/PIK3CA axis, which might provide the theoretical basis for the potential targeted therapy of hepatic carcinomas. The survival rate was significantly lower in the highly expressed lncRNA XIST group. Yes shlncRNA XIST attenuated cell proliferation, invasion and migration, while increasing the apoptosis of hepatic carcinoma cells. The lncRNA XIST negatively targeted miR-320a, and miR-320a negatively regulated the expression of PIK3CA. The miR-320a mimic and PIK3CA inhibitor could recover the effect of oe-lncRNA in terms of the proliferation, invasion, migration and apoptosis of hepatic carcinoma cells. 34630708 XIST LncRNA Homo sapiens Wilms Tumor tumor tissue regulation[inhibiting microRNA-193a-5p] qRT-PCR//Transwell Assay In this research, qRT-PCR results revealed a significantly higher expression of lncRNA XIST in tumor tissue specimens of patients with renal cell carcinoma than that in adjacent ones. In addition, we demonstrated that lncRNA XIST may accelerate the malignant progression of WT via inhibiting microRNA-193a-5p. Compared with patients with low expression of lncRNA XIST, those with high XIST expression had a higher incidence of distant metastasis and a lower overall survival rate. Yes Compared with the negative control group, the metastatic ability of WT cells in the lncRNA XIST knockdown group was markedly weakened. 33090392 XIST LncRNA Homo sapiens Lung Injury lung tissues of septic rats and lipopolysaccharide-stimulated cells Interaction(miR-16-5p) RNA Pull-Down//Western Blot//Tunel//qRT-PCR//RIP//MTT//Luciferase Report Assay//H&E Staining//ELISA We found that XIST expression was down-regulated in lung tissues of septic rats and lipopolysaccharide-stimulated cells, while the expression of miR-16-5p was up-regulated. Mechanistically, it was confirmed that XIST could sponge miR-16-5p, and thus repress its expression, and the transfection of miR-16-5p mimics could reverse the effects of XIST over-expression in the cell model. Yes Down-regulation of XIST significantly promoted pulmonary edema, increased the levels of TNF-α, IL-1β and malondialdehyde, inhibited the cell viability and decreased the level of superoxide dismutase. 33978928 XIST LncRNA Homo sapiens Chordoma chordoma tissues regulation[miR-124-3p/iASPP Pathway] CCK8//qRT-PCR//Flow Cytometry We found that lncRNA XIST expression was upregulated in chordoma and strongly correlated with poor patient prognosis.Our findings demonstrate a key role for lncRNA XIST in chordoma progression by regulating miR124-3p/iAPSS pathway. We found that lncRNA XIST expression was upregulated in chordoma and strongly correlated with poor patient prognosis. Yes Moreover, lncRNA XIST promoted proliferation and inhibited apoptosis of chordoma cells. 32547104 XIST LncRNA Homo sapiens Chordoma chordoma tissues Interaction( miR-320d/ARF6) RNA Pull-Down//IHC//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay XIST was overexpressed in chordoma tissues. XIST acted as a sponge of miR-320d. Moreover, miR-320d overexpression inhibited the proliferation, migration, invasion, and glycolysis of chordoma cells. ARF6 was a direct target of miR-320d, and XIST upregulated ARF6 expression via sponging miR-320d. Furthermore, overexpression of ARF6 reversed the inhibitory effects of XIST knockdown on chordoma cell proliferation, migration, invasion, and glycolysis. Yes XIST knockdown suppressed chordoma cell proliferation, migration, invasion, and glycolysis. 35899235 XIST LncRNA Homo sapiens Cerebral Ischaemia/Reperfusion Injury SH-SY5Y cells Interaction(miR-486-5p and GAB2) Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay XIST and GAB2 were significantly highly expressed, while miR-486-5p was low expressed in SH-SY5Y cells under I/R. For our experiment, miR-486-5p was a target of XIST, and GAB2 was a downstream gene of miR-486-5p. Furthermore, miR-486-5p mimic promoted cell proliferation and inhibited cell apoptosis, while XIST co-transfection reversed the effect of miR-486-5p. In addition, XIST was found to impair the inhibitory effect of miR-486-5p on expression of GAB2 in I/R cells. Yes XIST exacerbated the oxidative damage of I/R cells. Moreover, XIST was found to restrain cell viability and induce cell apoptosis. 33660813 XIST LncRNA Homo sapiens Prostatic Neoplasms PCa derived cells and tissues Interaction(miRNA -96-5p, miRNA -153-3p, and miRNA-182-5p) Western Blot//CCK8//qRT-PCR//Flow Cytometry//IF//Invasion Assay//Transwell Assay Our in vitro and in vivo results showed that the XIST gene expression level was higher in PCa derived cells and tissues compared to that in normal cells and tissues. Consistent with previous studies, we found that the role of XIST is mediated through via sponges, such as miRNA -96-5p, miRNA -153-3p, and miRNA-182-5p. Yes XIST gene expression level was positively correlated with the invasion and proliferation of tumour cells. Furthermore, the downregulation of XIST inhibited the growth of subcutaneous 22Rv1 xenografts in nude mice. 36038831 XIST LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell Regulation[XIST/miR-137/Notch-1 pathway] qRT-PCR//Luciferase Report Assay//Western Blot We confirmed that XIST is aberrantly upregulated in NSCLC tissues and cell lines. We identified a branch of the XIST/miR-137/Notch-1 pathway that regulates proliferation and TGF-β1-induced EMT in NSCLC, which could be involved in NSCLC progression. Yes XIST depletion inhibited cell proliferation and TGF-β1-induced EMT in A549 and H1299 cells. 29812958 XIST LncRNA Homo sapiens Adenocarcinoma LAD tissues and cells interaction[miR-363-3p] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay We found that XIST and MDM2 were remarkably elevated while miR-363-3p was reduced in LAD tissues and cells. XIST knockdown repressed proliferation, migration and invasion, and accelerated apoptosis of LAD cells by downregulating MDM2 expression via binding to miR-363-3p. Yes Both XIST and MDM2 downregulation restrained proliferation, migration and invasion, and facilitated apoptosis of LAD cells in vitro. 31968395 XIST LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction(miR-491-5p) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay In this study, we found that XIST expression was significantly upregulated in NPC tissues and cell lines. Further analysis revealed that XIST and miR-491-5p interact with and repress each other. XIST may function as an endogenous miR-491-5p sponge to regulate the target gene of miR-491-5p. Yes Knockdown of XIST inhibited NPC cell proliferation and invasion and induced apoptosis in vitro, as well as suppressed NPC tumor growth in vivo. 29219216 XIST LncRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues and cell lines Interaction[sponging miR-494] Western Blot//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Invasion Assay LncRNA XIST was overespressed in esophageal cancer tissues and cells. Yes Suppression of XIST significantly inhibited the proliferation, migration and invasion, but induced apoptosis of two kinds of cells, TE-1 and SKGT-4. 30551480 XIST LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Regulation[XIST/miR-140-5p/ORC1 axis] CCK8//qRT-PCR//EdU Staining//Western Blot MiR-140-5p was down-regulated but XIST and ORC1 were up-regulated in cervical cancer tissues and cell lines. Our study indicated the effects of XIST/miR-140-5p/ORC1 axis on the progression of cervical cancer which will shed new light on epigenetic diagnostics and therapeutics in cervical cancer. Yes Knocking down of the XIST or ORC1 memorably suppressed cell proliferation, blocked cell cycle, decreased the expression of Bcl-2 while increased the apoptosis rate and the expression of c-caspase3 and cleaved PARP in HeLa and C33A cells. 30858762 XIST LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cell lines interaction[miR-454] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay XIST was down-regulated in TNBC tissues and cell lines. In conclusion, XIST interacts with miR-454 to inhibit cells proliferation, EMT and induce apoptosis in TNBC, indicating a promising treatment strategy for TNBC patients. Yes Overexpressed XIST inhibited cell proliferation, epithelial mesenchymal transition (EMT) and induced apoptosis in vitro as well as suppressed TNBC tumor growth in vivo. 32098924 XIST LncRNA Homo sapiens Glioma cell line Interaction[IRS1/PI3K/Akt pathway ] RNA Pull-Down//Western Blot//qPCR//CCK8//Flow Cytometry//RIP//Luciferase Report Assay "RT‐qPCR and found a higher expression of lncRNA‐XIST in glioblastoma cells than in NHAs (P < .05; Figure 1B).LncRNA-XIST functioned as a competing endogenous RNA of miR-126 and then regulated IRS1/PI3K/Akt pathway in glioblastoma cells. In vivo results demonstrated lncRNA-XIST knockdown reduces the tumorigenicity of glioblastoma cells. Taken together, we demonstrated a novel cellular mechanism that was dependent of the lncRNA-XIST/miR-126/IRS1/PI3K/Akt pathway in enhanced glucose metabolism in glioma." Yes The study found that lncRNA-XIST knockdown inhibited cell viability, migration, invasion, resistance to apoptosis, and glucose metabolism of glioblastoma cells. 31680298 XIST LncRNA Homo sapiens Glioma glioma tissues regulation[upregulating miR-204-5p] qRT-PCR//Luciferase Report Assay XIST was upregulated in glioma tissues compared with normal brain tissues (NBTs), while miR-204-5p expression was significantly decreased in glioma tissues compared with NBTs.Our results provide evidence that XIST, miR-204-5p and Bcl-2 form a regulatory axis that controls glioma progression and can serve as a potential therapeutic target for glioma. Yes Knockdown of XIST inhibited glioma cell proliferation, migration, and invasion, promoted apoptosis of glioma cells, inhibited tumor growth and increased the survival time in nude mice. 32489472 XIST LncRNA Homo sapiens Glioma glioma tumors and cells regulation[miR-329-3p/CREB1 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay XIST and CREB1 were overexpressed whereas miR-329-3p was low-expressed in glioma tumors and cells compared with the normal counterparts.XIST accelerates cell proliferation, invasion and inhibits cell apoptosis by repressing radio-sensitivity of glioma via enhancing CREB1 expression through sponging miR-329-3p, representing prospective methods for glioma treatment. Yes XIST knockdown inhibited cell proliferation, invasion and induced cell apoptosis by enhancing cell sensitivity to X-ray radiation in glioma. 32271437 XIST LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction[XIST/miRNA-148a-3p/ADAM17 pathway] RNA Pull-Down//Western Blot//qPCR//Flow Cytometry//MTT//Luciferase Report Assay//Transwell Assay XIST was upregulated and miR-148a-3p was downregulated in NPC tissues and cell lines. In addition, miR-148a-3p was validated as a target of XIST, and silencing of miR-148a-3p could reverse XIST knockdown-mediated functions in SUNE-1 and CNE2 cells. Furthermore, miR-148a-3p was identified to target ADAM17, and ectopic expression of ADAM17 could abate miR-148a-3p-induced effects as well. Notably, ADAM17 was downregulated by XIST knockdown through upregulating miR-148a-3p. Yes Both XIST knockdown and miR-148a-3p overexpression promoted apoptosis, suppressed cell proliferation, migration, invasion, and EMT of NPC cells in vitro. In vivo, XIST knockdown resulted in a slower tumor growth. 31810117 XIST LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction(miR-30b/RECK axis ) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results of qPCR and western blotting indicated that the expression levels of lncRNA XIST and RECK were higher in the NPC tissues and cell lines than that of the control group, while the expression of miR-30b was lower. Our results showed that cell migration and invasion were inhibited by knockdown of lncRNA XIST, suggesting that the lncRNA XIST/miR-30b/RECK axis is involved in the development of NPC. Yes Knockdown of lncRNA XIST significantly inhibited cell proliferation, migration and invasion in the NPC cell lines. 33664820 XIST LncRNA Homo sapiens Atherosclerosis HVSMCs Regulation(miR-761/BMP9 axis) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Cell Cycle Assay//Transwell Assay Ox-LDL induced the proliferation and migration of HVSMCs, upregulated the expression of XIST, downregulated miR-761 expression, and activated the BMP9/ALK1/endoglin pathway. Luciferase assays revealed that XIST sponged miR-761. XIST knockdown ameliorated ox-LDL-mediated effects in HVSMCs, which were largely abolished by miR-761 silencing. BMP9 was targeted-inhibited by miR-761. MiR-761 overexpression alleviated ox-LDL-mediated effects in HVSMCs. However, BMP9 overexpression abolished miR-761-mediated effects in HVSMCs treated with ox-LDL. Our findings suggested that XIST knockdown suppressed the proliferation and migration of HVSMCs by promoting miR-761, which targeted-inhibited the BMP9/ALK1/endoglin pathway. Yes XIST knockdown ameliorated ox-LDL-mediated effects in HVSMCs, which were largely abolished by miR-761 silencing. BMP9 was targeted-inhibited by miR-761. 34595819 XIST LncRNA Homo sapiens Pancreatic Neoplasms PC tissues or PC cells regulation[miR-185-5p/CCND2 axis] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot Herein, we found that XIST expression was up-regulated while miR-185-5p was down-regulated both in PC tissues and cell lines, compared with that of controls.Taken together, our study demonstrated that lncRNA XIST functions as an oncogene and exerts its regulation via miR-185-5p/CCND2 axis, promoting proliferation and inhibiting apoptosis in PC. Yes Following that, functional experiments displayed that knockdown of XIST or overexpression of miR-185-5p inhibited cell proliferation, induced cell cycle arrest and promoted apoptosis in PC cells. 35117490 XIST LncRNA Homo sapiens Atherosclerosis HUVECs Interaction(miR-98-5p) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//MTT//Luciferase Report Assay//Cell Apoptosis Assay//ELISA We found ox-LDL repressed proliferation and induced inflammation and apoptosis in HUVECs. Loss-of-functional experiment suggested that the downregulation of XIST overturned the ox-LDL-induced effects on HUVECs. Additionally, overexpression of miR-98-5p-induced effects on ox-LDL-stimulated HUVECs was abolished by upregulation of XIST. However, silencing of miR-98-5p strengthened the ox-LDL-induced effects on HUVECs by increasing expression of PAPPA. Mechanistically, XIST could regulate PAPPA expression in ox-LDL-induced HUVECs by sponging miR-98-5p, providing understanding for atherosclerosis. Yes Loss-of-functional experiment suggested that the downregulation of XIST overturned the ox-LDL-induced effects on HUVECs. Additionally, overexpression of miR-98-5p-induced effects on ox-LDL-stimulated HUVECs was abolished by upregulation of XIST. 33542956 XIST LncRNA Homo sapiens Atherosclerosis VSMCs Interaction(XIST/miR-599/TLR4 axis) Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay we uncovered that the XIST level was elevated in the serum of AS patients and ox-LDL-treated AS cell models. Functional analysis revealed that XIST depletion restrained cell proliferation, while induced the apoptosis in AS cell models. Besides, miR-599 was verified to be a direct downstream target of XIST and miR-599 inhibitor reversed the effects of XIST knockdown on AS progression. Finally, we demonstrated that XIST increased TLR4 expression by serving as a ceRNA of miR-599. Yes Functional analysis revealed that XIST depletion restrained cell proliferation, while induced the apoptosis in AS cell models. 33566259 XIST LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues and cell lines Regulation[ XIST/miR-34a axis,MET-PI3K-AKT signaling] Immunoblotting//qRT-PCR//RIP//MTT//Luciferase Report Assay//BrdU XIST was significantly up-regulated in thyroid cancer tissues and cell lines;In thyroid cancer tissues, MET mRNA and protein levels of MET were up-regulated; MET was positively correlated with XIST while negatively correlated with miR-34a, further confirming that XIST serves as a ceRNA for miR-34a through sponging miR-34a, competing with MET for miR-34a binding, and finally modulating thyroid cancer cell proliferation and tumor growth. Yes XIST knockdown suppressed the cell proliferation in vivo and the tumor growth in vitro. 30463570 XIST LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines regulation[MiR-101-3p/CLDN1 Axis] qRT-PCR//Luciferase Report Assay//Transwell Assay LncRNA XIST was upregulated in PTC tissues and cells. XIST promotes migration and invasion of papillary thyroid cancer cell via directly regulating miR-101-3p/CLDN1 axis, which is a novel mechanistic of XIST in the regulation of PTC. Yes XIST knockdown suppressed migration and invasion of PTC cells. 33057875 XIST LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues Interaction[targeting miR-141-3p] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay These results indicate that (i) XIST is highly expressed in tumor tissues while miR-141-3p is down-regulated.MiR-141-3p inhibitor alleviates the inhibitory effect by siXIST in PC cell lines. (iv) MiR-141-3p directly interacts with XIST and also negatively regulates transforming growth factor-β 2 (TGF-β2) expression. (v) Overexpression of XIST attenuates the inhibition of TGF-β2 expression by miR-141-3p. The conclusion, is that XIST could promote proliferation, migration and invasion of PC cells via miR-141-5p/TGF-β2 axis. Yes Silencing XIST inhibits the pancreatic cell proliferation, migration and invasion. 31213574 XIST LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines Interaction[XIST/miR-429/ZEB1] Wound Healing Assay//qPCR//Western Blot//Transwell Assay qPCR was applied to detect the expression levels of XIST and miR-429 in PC tissues and cell lines.We identified the critical axis of XIST/miR-429/ZEB1 in PC cell migration, invasion and EMT, which may aid in developing new therapeutic strategies for PC. Yes Knockdown of XIST in two PC cell lines caused inhibition of migration, invasion and EMT capacities. Forced expression of miR-429 exerted the similar tumor suppressing effects. 31163263 XIST LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells regulation[miR-137 and Notch1 pathway] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay Results demonstrated that XIST expression was increased in PC tissues and cells. To sum up, these results proposed that XIST functioned as an endogenous sponge in promoting PC cell proliferation through competing for miR-137 to regulate Notch1 expression, and may provide more therapeutic targets for the patients with PC. Yes XIST knockdown inhibited PC cell proliferation in vitro and also repressed the tumor growth in vivo. 33336734 XIST LncRNA Homo sapiens Silicosis TGF-β1 stimulated lung epithelial cells Interaction(miR-101-3p/ZEB1 axis) Western Blot//Transfection//qRT-PCR//FISH//Luciferase Report Assay The results reveal that LncRNA XIST and ZEB1 are up-regulated while the miR-101-3p expression is down-regulated in vivo and vitro models. Moreover, the results also illustrate that LncRNA XIST is mainly localized in the cytoplasm used FISH and possesses binding site with miR-101-3p which was identified as the target of ZEB1 used bioinformatics prediction website and Dual-luciferase reporter assay. The above demonstrated that LncRNA-XIST regulates ZEB1 by directly sponging miR-101-3p. Yes Furthermore, the knockdown of LncRNA XIST prevents the EMT process and the inhibition of miR-101-3p markedly promotes EMT stimulated by TGF-β1. 35271943 XIST LncRNA Homo sapiens Heart Injuries H9C2 cardiomyocytes and myocardial tissues. Interaction(miR-150-5p/c-Fos axis) In Vivo Experiment//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA//ChIP After exposure to LPS, XIST and c-Fos levels were upregulated, but miR-150-5p was downregulated in H9C2 cardiomyocytes and myocardial tissues. Moreover, XIST knockdown attenuated LPS-induced injury in H9C2 cells by targeting the miR-150-5p/c-Fos axis. c-Fos could bound to the promoter of the TXNIP/XIST gene and enhanced TXNIP/XIST expression. Silencing of XIST improved cardiac function and survival rate and reduced apoptosis and pyroptosis by regulating the miR-150-5p/c-Fos axis in septic rats in vivo. Yes XIST affected viability, apoptosis, and pyroptosis in LPS-challenged H9C2 cells. Silencing of XIST improved cardiac function and survival rate and reduced apoptosis and pyroptosis by regulating the miR-150-5p/c-Fos axis in septic rats in vivo. 34045679 ZEB2-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues interaction[combining with EZH2] Western Blot//CCK8//qRT-PCR//Flow Cytometry//EdU Staining//Transwell Assay ZEB2-AS1 was highly expressed in osteosarcoma tissues, especially in advanced and metastatic groups.The long non-coding RNA, ZEB2-AS1, enhanced the proliferation and invasion of osteosarcoma cells and inhibited the cell apoptosis by combining with EZH2, and thereby promoted the development of osteosarcoma. Yes Interfering with ZEB2-AS1 suppressed cell proliferation and enhanced cell apoptosis. 32633340 WT1-AS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[down-regulating TGF-β1] qRT-PCR We found that WT1-AS was down-regulated, while TGF-β1 was upregulated in NSCLC tissues. Therefore, WT1-AS over-expression may inhibit non-small cell lung cancer cell stemness by down-regulating TGF-β1. Survival analysis showed that low levels of WT1-AS expression predicted poor survival of NSCLC patients. Yes WT1-AS over-expression resulted in inhibited cancer cell stemness. 32349718 WT1-AS LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer samples Interaction(PIK3AP1 ) In Vivo Experiment//Western Blot//Transfection//EdU Staining//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis//ChIP We found decreased expression of lncRNA WT1-AS and increased expression of PIK3AP1 in cervical cancer samples. In summary, lncRNA WT1-AS repressed the development of cervical cancer by reducing PIK3AP1 expression through an interaction with SPI1, which may suggest new therapeutic approaches for treating cervical cancer. Yes Moreover, PIK3AP1 was negatively regulated by WT1-AS, which promoted apoptosis, but inhibited cell proliferation and autophagy of cervical cancer cells. Furthermore, WT1-AS inhibited PIK3AP1 expression by recruiting SPI1, and inhibited the progression of cervical cancer through the SPI1/PIK3AP1 axis in vivo and in vitro.  34839795 WT1-AS LncRNA Homo sapiens Uterine Cervical Neoplasms cervical tissues and cell lines Interaction(miR-205) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Invasion Assay WT1-AS was downregulated in cervical tissues and cell lines. Moreover, miR-205, as a target gene of WT1-AS, was increased in cervical tissues and cell lines. Besides, miR-205 mimic reversed the effect of WT1-AS upregulation on cell cycle, apoptosis, migration, invasion, and EMT. Yes Also, WT1-AS caused the curb of xenograft tumor growth in vivo. Upregulation of WT1-AS promoted cell apoptosis, blocked cell cycle, migration, invasion, and EMT in vitro. 32319820 WT1-AS LncRNA Homo sapiens Triple Negative Breast Neoplasms breast cancer tissues Interaction[downregulate TGF-β] qRT-PCR//Transwell Assay//Western Blot We found that WT1-AS was downregulated in TNBC tissues than in nontumor tissues and decreased with increase in clinical stages. Transforming growth factor β1 (TGF-β1) was upregulated in TNBC tissues and inversely correlated with WT1-AS. TGF-β1 overexpression did not significantly affect WT1-AS in BT-549 cells, but WT1-AS negatively regulated the expression of TGF-β1. Yes WT1-AS overexpression caused inhibited migration and invasion of TNBC cells. TGF-β1 overexpression showed opposite functions and reduced the effects of WT1-AS overexpression. 31621381 circPAN3 CircRNA Mus musculus Myocardial Infarction heart tissue regulation[miR-221/FoxO3/ATG7 axis] RNA Pull-Down//ChIP//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Elevated circPAN3 was found in rat MI heart tissue, of which knockdown attenuated cardiac fibrosis after MI.circPAN3 exhibited profibrotic effects during autophagy-mediated cardiac fibrosis via miR-221/FoxO3/ATG7 axis, which may serve as potential biomarkers for cardiac fibrosis therapeutics. Yes In an in vitro model exposing with TGFβ1, increasing cell proliferation and migration were observed, whereas these effects were abolished by circPAN3 knockdown, as well as autophagy activity. 32629000 hsa_circ_0060745 CircRNA Mus musculus Myocardial Infarction brain tissues regulation[ NF-κB activation] Western Blot//Tunel//Migration Assay//Flow Cytometry//qRT-PCR We found that the expression of circ_0060745 was significantly increased in the myocardium of AMI mice and was mainly expressed in myocardial fibroblasts.These protective effects could be attributed to inhibition of NF-κB activation. Yes The knockdown of circ_0060745 decreased myocardial infarct size and improved systolic cardiac functions after AMI. The knockdown of circ_0060745 in cardiac fibroblasts inhibited the migration of peritoneal macrophage, the apoptosis of cardiomyocytes and the expressions of IL-6, IL-12, IL-1β, TNF-α and NF-κB under hypoxia. Overexpression of circ_0060745 caused an increase in infarct size and worsened cardiac functions after AMI. 32977365 circFndc3b CircRNA Mus musculus Myocardial Infarction heart tissues Regulation[FUS/VEGF-A axis] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Microarray Here we report identification of circRNA transcripts that are differentially expressed in post myocardial infarction (MI) mouse hearts including circFndc3b which is significantly down-regulated in the post-MI hearts. Adeno-associated virus 9 -mediated cardiac overexpression of circFndc3b in post-MI hearts reduces cardiomyocyte apoptosis, enhances neovascularization and improves left ventricular functions. Mechanistically, circFndc3b interacts with the RNA binding protein Fused in Sarcoma to regulate VEGF expression and signaling. These findings highlight a physiological role for circRNAs in cardiac repair and indicate that modulation of circFndc3b expression may represent a potential strategy to promote cardiac function and remodeling after MI. Yes Overexpression of circFndc3b in cardiac endothelial cells increases vascular endothelial growth factor-A expression and enhances their angiogenic activity and reduces cardiomyocytes and endothelial cell apoptosis. 31541092 WT1-AS LncRNA Homo sapiens cervical squamous cell carcinoma CSCC tissues Expression[lower expressed] qRT-PCR//Western Blot We found that HPV infection failed to affect WT1-AS expression in CSCC tissues, while WT1-AS was down-regulated in CSCC tissues compared with non-cancer tissues. Significantly up-regulated p53 was observed after WT1-AS over-expression in CSCC cells, while p53 over-expression failed to affect WT1-AS. Analysis of the survival of CSCC patients revealed that low levels of WT1-AS were accompanied by poor survival. Yes P53 and WT1-AS over-expression resulted in the inhibited proliferation of CSCC cells. 31694597 WT1-AS LncRNA Homo sapiens Osteoporosis osteoblasts Interaction( p53) qRT-PCR//ELISA//Cell Apoptosis Assay//Western Blot WT1-AS was upregulated during osteoporosis and regulated the apoptosis of osteoblasts by interacting with p53. Yes In osteoblasts, WT1-AS overexpression resulted in increased p53 expression, while WT1-AS small interfering RNA (siRNA) silencing resulted in decreased p53 expression. In addition, WT1-AS overexpression resulted in increased apoptosis rate, while WT1-AS siRNA silencing resulted in decreased apoptosis rate in osteoblasts. 34055051 WT1-AS LncRNA Homo sapiens Ischemic Stroke blood samples of patients Interaction(miR-186-5p/XIAP axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay The results showed that miR-186-5p is a direct target of the lncRNA WT1-AS. In addition, lncRNA WT1-AS levels were downregulated and miR-186-5p levels were upregulated in the blood samples of patients with ischemic stroke and OGD-induced SH-SY5Y cells. In conclusion, lncRNA WT1-AS attenuates hypoxia/ischemia-induced neuronal injury in cerebral ischemic stroke through the miR-186-5p/XIAP axis. Yes WT1-AS overexpression promoted OGD-induced cell viability and reduced the cell apoptosis and caspase 3 activity. However, these effects were reversed by miR-186-5p overexpression. 35959150 WT1-AS LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Regulation[miR-330-5p/p53 axis] qRT-PCR//IF Our results demonstrated that WT1-AS was remarkably down-regulated in cervical carcinoma. In addition, the luciferase reporter assay identified that miR-330-5p was the target of WT1-AS. Moreover, tumor suppressor p53 was identified as the direct target of miR-330-5p and alternation of miR-330-5p/p53 axis reversed the effects of WT1-AS in cervical cancer cell. Yes Functional assays proved that up-regulation of WT1-AS significantly suppressed cervical cancer cell proliferation, migration and invasion. 30666161 WSPAR LncRNA Homo sapiens Asthma airway smooth muscle cells Regulation[TIMMDC1/Akt axis] Western Blot//qRT-PCR//MTT//EdU Staining//Transwell Assay We discovered that lncTCF7 and TIMMDC1 were upregulated in asthma groups and lncTCF7 improved ASMCs viability/proliferation and migration.Our study uncovered that lncTCF7 facilitated human ASMCs growth and migration via targeting TIMMDC1 thus activating AKT signaling, providing a novel possible target for asthma therapy. Yes We discovered that lncTCF7 and TIMMDC1 were upregulated in asthma groups and lncTCF7 improved ASMCs viability/proliferation and migration. 30528236 WiNTRLINC1 LncRNA Homo sapiens Colonic Neoplasms Colon Cancer Regulation[WiNTRLINC1/ASCL2/c-Myc Axis] qRT-PCR Real-time quantitative reverse transcriptase-polymerase chain reaction confirmed definite overexpression of WiNTRLINC1 mRNA in primary colon cancer compared with the corresponding normal colon mucosa tissues (p = 0.0005), such as ASCL2, c-Myc, and PRL-3 (p < 0.0001). Yes Knockdown of the WiNTRLINC1 gene reduced the expression of ASCL2/c-Myc, but rather augmented PRL-3 at mRNA level, and robustly affected cell viability in colon cancer cell lines. 31549316 WFDC21P LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues Interaction(FOXP3/GTPase Ran / Akt/GSK3β/β-catenin pathway.) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Microarray//Colony Formation Assay//Invasion Assay//Transwell Assay LncRNA WFDC21P was significantly upregulated in GC cells and tissues, and clinically associated with the pathological stages of advanced GC. LncRNA WFDC21P was directly bound to GTPase Ran and it promoted the activity of the Akt/GSK3β/β-catenin pathway. Forkhead Box P3 (FOXP3), as a transcription factor of WFDC21P, was directly bound to the promoter region and it positively regulated the transcription of WFDC21P. Yes WFDC21P promoted proliferation and metastasis of GC cells both in vitro and in vivo. 34601496 WFDC21P LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Interaction(triple-negative breast cancer) qRT-PCR//MeRIP//RIP Results of this study demonstrated that WFDC21P levels significantly increased in TNBC, which was associated with the poor survival of patients. WFDC21P interacted with miR-628-5p, which further suppressed cell proliferation and metastasis by negatively regulating Smad3-related gene expression. Recovery of miR-628-5p weakened the roles of WFDC21P in promoting the growth and metastasis of TNBC cells. Moreover,N6-methyladenosine (m6A) modification upregulated WFDC21P expression in the TNBC cells. WFDC21P and its m6A levels were increased after methyltransferase like 3 (METTL3) overexpression but reduced after METTL3 silencing. Results of this study demonstrated that WFDC21P levels significantly increased in TNBC, which was associated with the poor survival of patients. Yes WFDC21P overexpression significantly promoted TNBC cell proliferation and metastasis. 36387210 WFDC21P LncRNA Homo sapiens lung carcinoma cells Interaction(miR-4293) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//MTT//RNA-seq//Colony Formation Assay//Transwell Assay DCP2 can directly or indirectly bind to WFDC21P and downregulates its expression. Consequently, miR-4293 can further promote WFDC21P expression by regulating DCP2. Overall, our results establish oncogenic roles for both miR-4293 and WFDC21P and demonstrate that interactions between miRNAs and lncRNAs through DCP2 are important in the regulation of carcinoma pathogenesis. Yes Furthermore, knockdown of WFDC21P results in functional attenuation of miR-4293 on tumor promotion. In vivo xenograft growth is also promoted by both miR-4293 and WFDC21P. 34301920 WEE2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[HBx-WEE2-AS1- FERMT3 pathway ] Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay WEE2-AS1 over-expressed in HCC and was positively correlated to hepatitis B virus (HBV) infection, hepatic vascular invasion, poor tumor differentiation and poor patient prognosis. Fermitin family member 3 (FERMT3) was a downstream target of WEE2-AS1. In conclusion, there is a preliminary HBx-WEE2-AS1- FERMT3 pathway which may serve as a therapeutic target for HBV-associated HCC. Yes WEE2-AS1 also accelerated the proliferation, migration, invasion and cell cycle progression of HCC cells. 30471857 WEE2-AS1 LncRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-29b-2-5p/TPM3 Axis) Western Blot//qRT-PCR//FISH//IF//Colony Formation Assay//EdU Staining//Transwell Assay An investigation of the GEPIA database revealed that long noncoding RNA WEE2 antisense RNA 1 (WEE2-AS1) is upregulated in glioma tissues compared to normal brain tissues, and validation with quantitative real-time polymerase chain reaction (qRT-PCR) revealed that WEE2-AS1 expression was consistent with the database prediction. Bioinformatics predictions and integrated experiments indicated that WEE2-AS1 promoted tropomyosin 3 (TPM3) expression by sponging miR-29b-2-5p. A dual-luciferase reporter assay was conducted to uncover the binding of WEE2-AS1 and miR-29b-2-5p and that of miR-29b-2-5p and TPM3. Additionally, a series of rescue assays showed that WEE2-AS1 promotes proliferation, migration, and invasion by targeting miR-29b-2-5p to regulate TPM3 expression. Yes Functional experiments revealed that the downregulation of WEE2-AS1 impeded cell proliferation, migration, and invasion in glioma cell lines. Furthermore, downregulation of WEE2-AS1 suppressed tumor growth in vivo. 35393008 WEE2-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cell lines regulation[miR-32-5p/TOB1 axis] RNA Pull-Down//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Our results showed that WEE2-AS1 was up-regulated in TNBC cell lines, and WEE2-AS1 knockdown could inhibit TNBC cell proliferation, promote apoptosis, and suppress migration and invasion.Through rescue assays, we proved that WEE2-AS1/miR-32-5p/TOB1 axis could modulate cancer progression in TNBC cells. Yes Our results showed that WEE2-AS1 was up-regulated in TNBC cell lines, and WEE2-AS1 knockdown could inhibit TNBC cell proliferation, promote apoptosis, and suppress migration and invasion. 32307083 WT1-AS LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Regulation[miR-203a-5p/FOXN2 axis ] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay WT1-AS was down-regulated in both cervical cancer tissues and cell lines. The results of the Luciferase reporter assays verified that miR-203a-5p is a direct target of WT1-AS. Moreover, FOXN2 was identified as a direct target gene of miR-203a-5p, and the up-regulation of miR-203a-5p reversed the inhibitory effects of WT1-AS in cervical cancer cells. Yes Functional analyses indicated that the over-expression of WT1-AS remarkably inhibited cervical carcinoma cell growth, migration and invasion. 30720155 XIST LncRNA Homo sapiens Carcinoma, Hepatocellular HBV-related HCC tissues and HepG2.2.15 cells Interaction(miR-192/TRIM25) Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay qRT-PCR results showed that the expression levels of lncRNA XIST were remarkably increased in HBV-related HCC tissues and HepG2.2.15 cells. In addition, miR-192 was a direct target gene of lncRNA XIST, and the expression of miR-192 and lncRNA XIST were negatively correlated.Furthermore, TRIM25 was a direct target of miR-192, and lncRNA XIST could up-regulate the expression of TRIM25 by targeting miR-192. Yes Moreover, overexpression of miR-192 observably inhibited the proliferation and migration of HCC cells, while overexpression of lncRNA XIST showed an opposite effect. 33858324 XIRP2-AS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissue,cell lines Interaction[ miR-182 ] RNA Pull-Down//ISH//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//MTT//Luciferase Report Assay//Microarray//Transwell Assay LncRNA XIRP2-AS1 was significantly less expressed in colon cancer tissue.XIRP2-AS1 was remarkably downregulated in colon cancer tissues and cell lines.miR-182 was validated as the target of XIRP2-AS1 according to luciferase reporter assays, RNA immunoprecipitation and RNA pull down. Clinical sample analysis showed that XIRP2-AS1 had a favorable impact on the overall survival and progression free survival of patients with colon cancer. Yes Functionally, XIRP2-AS1 could inhibit the proliferation and invasion ability of colon cancer cells in vitro and in vivo. 31410022 XIST LncRNA Homo sapiens Sleep Apnea Syndromes the adenoids of patients with OSAHS Regulation(GRα-NF-κB signaling pathway) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//ELISA//Bioinformatics Analysis Furthermore, reverse transcription-quantitative PCR showed that the expression of lncRNA XIST was significantly increased in the adenoids of patients with OSAHS compared with healthy controls. The stimulatory effect of XIST was significantly inhibited by the NF-κB inhibitor EVP4593. These results indicated that the stimulatory effect of XIST was dependent on NF-κB. In summary, the present study demonstrated that the XIST-GRα-NF-κB signaling pathway contributed to inflammation in the adenoids of patients with OSAHS. Yes Further in vitro studies by Pearson correlation analysis, RNA pull-down assay, western blot analysis and ELISA demonstrated that XIST significantly decreased the expression of GRα and that significantly increased the production of inflammatory cytokines, including interleukin (IL)-8, tumor necrosis factor α, IL-6 and IL-1β, while the overexpression of GRα significantly decreased the production of these inflammatory cytokines in NP69 cells, a human nasopharyngeal epithelial cell line. Furthermore, XIST significantly increased the protein levels of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) subunits, including Rel-B, c-Rel, P52, P50 and P65, which are associated with the transcription of cytokines. 33791009 XIST LncRNA Homo sapiens Neoplasms human ovarian granulosa-like tumor (KGN) cells Interaction( miR-30c-5p/BCL2L11 signaling axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay In this study, we discovered that the lncRNA XIST was significantly downregulated in human ovarian granulosa-like tumor (KGN) cells. In conclusion, this study established that lncRNA XIST plays a critical role in PCOS by modulating the miR-30c-5p/BCL2L11 signaling axis and regulating ovarian granulosa cell physiology. Yes Notably, overexpression of lncRNA XIST decreased miR-30c-5p expression in KGN cells, inhibited proliferation, and induced apoptosis in KGN cells. 35730492 Xist LncRNA Mus musculus Alzheimer Disease nerve cells, AD mice Interaction(EZH2/NEP ) RNA Pull-Down//Western Blot//Tunel//CCK8//RIP//qRT-PCR//Cell Apoptosis Assay//ELISA//ChIP The expression of lncRNA XIST was increased in AD mice and cell models. Inflammation and injury of nerve cells occurred in AD mice and cell models. LncRNA XIST affected the expression of Aβ-degrading enzyme NEP, and lncRNA XIST was negatively correlated with NEP expression in AD mice. LncRNA XIST regulated NEP expression partly through epigenetic regulation by binding with EZH2. LncRNA XIST mediated neuronal inflammation and injury through epigenetic regulation of NEP. Yes The knockdown of lncRNA XIST alleviated Aβ-induced neuronal inflammation and damage. 35098860 Xist LncRNA Mus musculus Cerebral Infarction microglia Regulation In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//ELISA It was revealed that lncRNA XIST was significantly upregulated in both a mouse cerebral infarction model induced by middle cerebral artery occlusion (MCAO) and an activated microglial model induced by oxygen/glucose deprivation (OGD). LncRNA XIST served as a sponge for miR-96-5p, counteracting its inhibitory effect on IKKβ/NF-κB signaling and TNF-α production. Notably, TNF-α was positively regulated by XIST and in turn enhanced XIST expression in microglia. The lncRNA XIST-TNF-α feedback promoted the proinflammatory polarization of microglia, thereby exacerbating cerebral neuron apoptosis. Yes The overexpression of XIST enhanced the expression and release of pro-inflammatory mediators [such as tumor necrosis factor (TNF)-α, IL-6, and iNOS] in microglia. Culture supernatant from lncRNA XIST-overexpressed microglial cells induced the apoptosis of primary neurons, while TNF-α antibody counteracted this neurotoxic effect. 34306193 Xist LncRNA Rattus norvegicus Diabetic Nephropathies DN rats and HK2 cells Interaction(miR-15b-5p/NLRP3/caspase-1-mediated RTEC pyroptosis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//ELISA//IF XIST was highly expressed in the DN models. Mechanistically, XIST sponged miR-15b-5p to regulate TLR4. Silencing XIST inhibited TLR4 by promoting miR-15b-5p. miR-15b-5p inhibition or TLR4 overexpression averted the inhibitory effect of silencing XIST on HG-induced RTEC pyroptosis. Yes XIST silencing improved renal metabolism and biochemical indices and mitigated renal injury. The expression of inflammation and pyroptosis indicators was significantly increased in DN rats and HG-treated HK2 cells; cell viability was decreased and LDH activity was increased after HG treatment. Silencing XIST inhibited RTEC pyroptosis by inhibiting NLRP3/caspase-1. 35582664 Xist LncRNA Rattus norvegicus Neuralgia chronic constriction injury (CCI) rat models Interaction(miR-544/STAT3) In Vivo Experiment//Western Blot//Transfection//qPCR//Luciferase Report Assay//ELISA In our current study, chronic constriction injury (CCI) rat models were established and we observed that lncRNA XIST was greatly increased.To conclude, our present study indicated that XIST can contribute to neuropathic pain progression in rats through down-regulating miR-544 and up-regulating STAT3. Yes Knockdown of XIST can relieve pain characteristics including both mechanical and thermal hyperalgesia in CCI rats. Meanwhile, XIST down-regulation could inhibit neuro-inflammation by reducing expression of inflammatory cytokines including tumor necrosis factor (TNF)-α, IL-1β, and IL-6 and in CCI rats. 29219175 Xist LncRNA Rattus norvegicus Neuralgia chronic constriction injury (CCI) rat models Interaction(miR-137 and TNFAIP1) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay In our study, we identify and validate that lncRNA XIST was markedly increased and miR-137 was significantly decreased in chronic constriction injury (CCI) rats. XIST was predicted to interact with miR-137 by bioinformatics technology and dual-luciferase reporter assays confirmed the correlation between XIST and miR-137. miR-137 was negatively modulated by XIST and upregulation of miR-137 greatly reduced neuropathic pain development in CCI rats. In conclusion, our current study indicates that XIST can positively regulate neuropathic pain in rats through regulating the expression of miR-137 and TNFAIP1. Yes XIST silencing alleviated pain behaviors including both mechanical and thermal hyperalgesia in the CCI rats. 29115665 Xist LncRNA Rattus norvegicus Aortic Aneurysm, Abdominal VSMCs Interaction(miR-762/MAP2K4 axis) In Vivo Experiment//Western Blot//Transfection//Luciferase Report Assay//ELISA XIST was highly expressed in Ang II-treated VSMCs. Cell proliferation ability was decreased and apoptosis was increased in VSMCs following Ang II treatment. XIST knockdown reversed the impact of Ang II on cell proliferation and apoptosis in VSMCs. XIST promoted mitogen-activated protein kinase kinase 4 (MAP2K4) expression by sponging miR-762. XIST overexpression suppressed cell proliferation and apoptosis of Ang II-treated VSMCs by regulating miR-762/MAP2K4 axis. Finally, Ang II-induced AAA mouse model was established to verify the function of XIST in AAA. Inhibition of XIST significantly attenuated the pathological changes of abdominal aorta tissues in Ang II-induced mice. The expression of miR-762 was inhibited, and MAP2K4 expression was enhanced by XIST knockdown in the abdominal aorta tissues of AAA mice. Yes XIST knockdown reversed the impact of Ang II on cell proliferation and apoptosis in VSMCs.XIST overexpression suppressed cell proliferation and apoptosis of Ang II-treated VSMCs by regulating miR-762/MAP2K4 axis. 34942175 circHIPK3 CircRNA Mus musculus Diabetic Nephropathies renal tissues interaction[sponging miR-185] qRT-PCR//Luciferase Report Assay Up-regulation of circHIPK3 was observed in the renal tissues of mice with DN.Overall, circHIPK3 exhibits a promotive function in DN by sponging miR-185 and this evidence suggests that circHIPK3 might be a biomarker or therapeutic target for DN. Yes A loss-of-function experiment indicated that down-regulation of circHIPK3 inhibited cell proliferation and significantly decreased mRNA abundance of cyclin D1, PCNA, TGF-β1, Col. I, and FN in MCs. 32889056 WT1-AS LncRNA Homo sapiens Thyroid Cancer, Papillary PTC and non-tumor tissues regulation[miR-203] CCK8//qRT-PCR We found that WT1-AS was significantly downregulated in PTC and associated with clinical stages.Therefore, WT1-AS may downregulate survivin by upregulating miR-203 in PTC to inhibit cancer cell proliferation. Yes Cell proliferation assay showed that overexpression of WT1-AS and miR-203 led to decreased, while survivin overexpression led to increased proliferation of PTC cells. 32021456 WWTR1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Expression[highly expressed] qRT-PCR Aberrant overexpression of WWTR1-AS1 in HNSCC samples showed a significant correlation between its higher expression levels and larger tumor size, cervical node metastasis, and poor prognosis. Aberrant overexpression of WWTR1-AS1 in HNSCC samples showed a significant correlation between its higher expression levels and larger tumor size, cervical node metastasis, and poor prognosis. Yes Aberrant overexpression of WWTR1-AS1 in HNSCC samples showed a significant correlation between its higher expression levels and larger tumor size, cervical node metastasis, and poor prognosis. 31172583 WWOX-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[WWOX-AS1/miR-20b-5p/WWOX axis] Western Blot//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our present study illustrated that WWOX-AS1 was lowly expressed in HCC tissues and cell lines. Collectively, WWOX-AS1/miR-20b-5p/WWOX axis suppresses HCC tumorigenesis, hinting a potential molecular mechanism for the therapy of HCC patients. Yes Through functional assays, we observed that upregulated WWOX-AS1 was correlated with decreased cell proliferation, migration, epithelial to mesenchymal transition (EMT) process and increased cell apoptosis, suggesting that WWOX-AS1 exerted anti-carcinogenic role in the development of HCC. 32931356 WT-AS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[KLK13] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay The results showed that WT-AS expression in NSCLC was remarkably lower than that in normal tissues adjacent to the cancer. This study shows for the first time that LncRNA WT-AS interacts with KLK13 to serve as a negative regulator of NSCLC progression. Univariate analysis suggested that compared with patients with high expression of WT-AS, patients in low expression group showed higher incidence of metastasis and lower survival rates. Yes Overexpression of WT-AS suppressed cell invasion and metastasis capacity, while the opposite result was observed in WT-AS knockdown group. 33015785 WTAPP1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[downregulating lncRNA HAND2-AS1] qRT-PCR//Transwell Assay The expression of WTAPP1 was upregulated in NSCLC. WTAPP1 may promote cancer cell invasion and migration in NSCLC by downregulating lncRNA HAND2-AS1. The survival analysis showed that low plasma levels of WTAPP1 were accompanied with high survival rate. Yes Overexpression of WTAPP1 led to promoted, while overexpression of HAND2-AS1 resulted in inhibited invasion and migration of NSCLC cells. 32473628 hsa_circ_15698 CircRNA Mus musculus Diabetic Nephropathies kidney cortex tissue Interaction[miR-185 / TGF-β1] qRT-PCR//Luciferase Report Assay//Western Blot CircRNAs microarray analysis revealed dysregulated circRNA in db/db DN mice, and circRNA_15698 was validated to be Expression[Expression[up-expression]-expression]regulated in both db/db mice and mouse mesangial cells (SV40-MES13) that were exposed to high glucose (25 mM) using real-time polymerase chain reaction.Bioinformatics tools and luciferase reporter assay confirmed that circRNA_15698 acted as a 'sponge' of miR-185, and then positively regulated the transforming growth factor-β1 (TGF-β1) protein expression, suggesting a circRNA_15698/miR-185/TGF-β1 pathway. Yes Loss-of-functional experiments showed that circRNA_15698 knockExpression[down-expression] significantly inhibited the expression levels of collagen type I (Col. I), collagen type IV (Col. IV), and fibronectin. 30054916 WTAPP1 LncRNA Homo sapiens laryngeal carcinoma tumor tissues regulation[microRNA-592] CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining QRT-PCR results revealed a significantly higher expression of lncRNA WTAPP1 in tumor tissues of patients with laryngeal cancer than that in adjacent normal ones.Additionally, lncRNA WTAPP1 is able to enhance the proliferation capacity of laryngeal carcinoma cells via regulating microRNA-592. Compared with patients with low expression of WTAPP1, those with higher expression had a more advanced pathological stage. Yes Meanwhile, the proliferation ability of cells in sh-WTAPP1 group was remarkably attenuated when compared with that in sh-NC group. 33015795 WT1-AS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung The 66 NSCLC patients included 30 cases of adenocarcinoma, 25 cases of squamous cell carcinoma and 11 cases of large cell carcinoma. Interaction(lncRNA UCA1) Western Blot//Migration Assay//CCK8//qRT-PCR//cell invasion assay WT1-AS was downregulated in NSCLC and was correlated with poor survival. LncRNA UCA1 was upregulated in cancer tissues and inversely correlated with WT1-AS. WT1-AS was downregulated in NSCLC and was correlated with poor survival. The expression of WT1-AS in NSCLC was not correlated with clinical stages. Yes Overexpression of UCA1 resulted in increased proliferation, EMT, migration and invasion of NSCLC cells, while overexpression of WT1-AS showed opposite effects. 33514344 WT1-AS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell lines Interaction(miR-494-3p/PI3K/AKT pathway ) Western Blot//Wound Healing Assay//Tunel//CCK8//qRT-PCR//Transwell Assay Visibly downregulated WT1-AS in NSCLC cell lines was obtained from Broad Institute Cancer Cell Line Encyclopedia (CCLE) database and further verified by performing RT-qPCR. Besides, miR-494-3p was the downstream target gene of WT1-AS and obviously upregulated miR-494-3p in NSCLC cell lines was confirmed. In addition, WT1-AS promoted PTEN expression and thereby inhibited activation of PI3K/AKT pathway by sponging miR-494-3p. Yes WT1-AS overexpression suppressed cell proliferation, migration and invasion abilities while enhanced cell apoptosis of A549 and NCI-H1975 cells. Furthermore, upregulation of miR-494-3p distinctly reversed these inhibitory effects of WT1-AS overexpression on the tumorigenesis and progression of NSCLC. 33603394 XIST LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow cells Interaction(miR-196b) CCK8//qRT-PCR//Western Blot The expression level of lncRNA XIST in bone marrow cells in the AML group was significantly lower than that in the iron deficiency anemia group (P<0.001). Compared with pcDNA-XIST group, the cell activity, proportion of S-phase cells, and the expression levels of pro-caspase3 and Bcl-2 in the pcDNA-XIST+miR-196b group were significantly increased (all P<0.001), while the proportion of cells in the G0/G1 phase, apoptosis rate, and the expression levels of cleaved-caspase3 and Bax decreased (all P<0.001). Yes Compared with pcDNA group, the expression level of lncRNA XIST, proportion of cells in G0/G1 phase, apoptosis rate, and the expression levels of cleaved-caspase3 and Bax in the pcDNA-XIST group of KG1a cells were significantly increased (all P<0.001), while the expression level of miR-196b, cell viability, the proportion of S-phase cells, and the expression levels of pro-caspase3 and Bcl-2 were significantly decreased (all P<0.001). 36208229 XIST LncRNA Homo sapiens Leukemia, Myeloid, Acute AML bone marrow cells regulation[elevating microRNA-29a expression] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay XIST and MYC were up-regulated, and miR-29a was down-regulated in AML bone marrow cells. Yes Silencing XIST inhibited cellular activity and drug resistance but promoted cellular apoptosis of KG-1 cells by down-regulating MYC.silencing XIST inhibited tumorigenesis of AML cells in vivo. 33228517 XIST LncRNA Homo sapiens Parkinson Disease brain tissue Interaction(miR-199a-3p/Sp1/LRRK2 signal pathway) CCK8//qRT-PCR The results indicated that miR-199a-3p expression was downregulated, whereas that of XIST, Sp1 and LRRK2 were upregulated in Parkinson's disease. The neurodegenerative defects were significantly recovered by treating the cells with shXIST or shSp1, whereas miR-199a-3p inhibition or Sp1 and LRRK2 overexpression abrogated these beneficial effects. Furthermore, the results of our in vivo experiments confirmed the neuroprotective effects of shXIST and miR-199a-3p against MPTP-induced brain injuries, and the Parkinson's disease behavioural symptoms were effectively alleviated upon shXIST or miR-199a-3p treatment. Yes Moreover, miR-199a-3p overexpression or XIST knockdown inhibited the cell apoptosis induced by MPP+ treatment and promoted cell proliferation. The neurodegenerative defects were significantly recovered by treating the cells with shXIST or shSp1, whereas miR-199a-3p inhibition or Sp1 and LRRK2 overexpression abrogated these beneficial effects. 33494069 ZEB1-AS1 LncRNA Homo sapiens Liver Neoplasms Hepatocarcinoma tissue Interaction[targeting miR-365a-3p] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay Additionally, reverse transcription-quantitative polymerase chain reaction demonstrated that levels of ZEB1-AS1 were abnormally upregulated in liver cancer and this was positively correlated with E2F2 expression. The results also demonstrated that ZEB1-AS1 positively regulates E2F2 expression by competitively binding to miR-365a-3p. Furthermore, high levels of ZEB1-AS1 exhibited a trend for poor survival in patients with liver cancer. Yes EdU staining and flow cytometry analysis indicated that downregulation of ZEB1-AS1 could suppress cell proliferation and decrease the S phase proportion of liver cancer cells, which was effectively reversed by the inhibition of miR-365a-3p. 30988735 ZEB1-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BLCA tissues Regulation[ TGF-β1/ZEB1-AS1/miR-200b/FSCN1 axis ] Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Moreover, the oncogenic long non-coding RNA ZEB1-AS1 was highly expressed in BLCA and positively correlated with high tumor grade, high TNM stage, and reduced survival of patients with BLCA.Furthermore, we found TGF-β1 induced migration and invasion in BLCA by regulating the ZEB1-AS1/miR-200b/FSCN1 axis. Moreover, the oncogenic long non-coding RNA ZEB1-AS1 was highly expressed in BLCA and positively correlated with high tumor grade, high TNM stage, and reduced survival of patients with BLCA. Yes Moreover, ZEB1-AS1 downregulated the expression of miR-200b, promoted migration, invasion, and proliferation, and inhibited apoptosis in BLCA. 30823924 ZEB1-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms cell lines Interaction[ZEB1 ] RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//FISH//RIP//IHC//Invasion Assay Reverse transcription quantitative polymerase chain reaction analysis showed that ZEB1‑AS1 was upregulated in BCa cells compared with normal epithelial cells. In conclusion, the data from the present study demonstrated that ZEB1‑AS1 induced BCa metastasis via an AUF1‑mediated translation activation of ZEB1 mRNA mechanism. Yes Functionally, knockdown of ZEB1‑AS1 suppressed BCa cell migration and invasion in vitro, and metastasis in vivo. 31115480 ZEB1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cancer tissues Interaction(miR-23a) qRT-PCR//Luciferase Report Assay//Western Blot The up-regulation of ZEB1-AS1 and downregulation of miR-23a-3p (miR-23a) were found in OSCC cancer tissues. A ZEB1-AS1 knockdown remarkably suppressed in vitro cancerous, biological processes of OSCC cell lines such as cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT). The tumor growth was also inhibited by silencing ZEB1-AS1 in vivo, and a DLR assay confirmed the association between ZEB1-AS1 and miR-23a. Yes A ZEB1-AS1 knockdown remarkably suppressed in vitro cancerous, biological processes of OSCC cell lines such as cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT). The tumor growth was also inhibited by silencing ZEB1-AS1 in vivo, and a DLR assay confirmed the association between ZEB1-AS1 and miR-23a. 33888994 circUCK2 CircRNA Mus musculus Reperfusion Injury brain tissues regulation[miR-125b-5p/GDF11 Signaling] CCK8//qRT-PCR//Tunel The levels of circUCK2 were significantly decreased in brain tissues from a mouse model of focal cerebral ischemia and reperfusion. Consequently, these findings showed that the circUCK2/miR-125b-5p/GDF11 axis is an essential signaling pathway during ischemia stroke. Yes Upregulated circUCK2 levels significantly decreased infarct volumes, attenuated neuronal injury, and improved neurological deficits. 33230465 ZEB1-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells regulation[miR-505-3p/TRIB2 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our results revealed that ZEB1-AS1 expression was significantly upregulated in PC tissues and cells, and the high expression of ZEB1-AS1 indicated the low overall survival rate in PC patients. These results confirmed that ZEB1-AS1 promoted the tumorigenesis of PC through the miR-505/TRIB2 axis, which indicated that ZEB1-AS1 might function as a biomarker for PC treatment and provide a new therapeutic direction in PC. Our results revealed that ZEB1-AS1 expression was significantly upregulated in PC tissues and cells, and the high expression of ZEB1-AS1 indicated the low overall survival rate in PC patients. Yes Loss-of-function and gain-of-function assays indicated that knockdown of ZEB1-AS1 inhibited the cell viability, migration and invasion of PC cells, while overexpression of ZEB1-AS1 promoted PC cell progression. 32513531 ZEB1-AS1 LncRNA Homo sapiens Cholangiocarcinoma IHCC cell lines and tissues regulation[miR-200a/ZEB1 signaling pathway ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay In the present study, ZEB1?AS1 was found to be upregulated in IHCC cell lines and tissues. On the whole, the findings of the present study demonstrate that ZEB1‑AS1 promotes proliferation and metastasis in IHCC, and induces EMT through the miR‑200a/ZEB1 signaling pathway. A high ZEB1?AS1 expression was associated with clinical progression and a poor survival of patients with IHCC, and was identified as an independent risk factor for a poor prognosis. Yes In addition, ZEB1?AS1 promoted the proliferation and metastasis of IHCC cells both in vitro and in vivo. 32236578 ZEB1-AS1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells regulation[PI3K/AKT/mTOR signaling,miR-342-3p/CUL4B axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay ZEB1-AS1 and CUL4B were upregulated and miR-342-3p was downregulated in PCa tissues and cells. ZEB1-AS1 modulated PCa progression through mediating PI3K/AKT/mTOR signaling by miR-342-3p/CUL4B axis, providing a possible strategy for the treatment of PCa. Yes Both ZEB1-AS1 and CUL4B inhibition constrained proliferation, migration, and invasion of PCa cells. 32275162 ZEB1-AS1 LncRNA Homo sapiens Melanoma melanoma cell lines and tumor tissues Interaction[ZEB1-AS1/miR-1224-5p] qRT-PCR//Luciferase Report Assay The expression levels of ZEB1-AS1 were increased in melanoma cell lines and tumor tissues as indicated by reverse transcription-quantitative polymerase chain reaction analysis. In addition, the ZEB1-AS1/miR-1224-5p interaction may be a promising therapeutic target for melanoma treatment. Kaplan-Meier analysis suggested that higher expression of ZEB1-AS1 predicts poor prognosis of melanoma patients. Yes Furthermore, knockdown of ZEB1-AS1 inhibited the proliferation, migration and invasion of melanoma, suggesting a role of ZEB1-AS1 in the development and progression of melanoma. 30651872 ZEB1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Interaction[inhibiting ZEB1] Western Blot//ISH//qPCR//CCK8//IHC//Transwell Assay Here, we discovered that ZEB1-AS1 and ZEB1 were markedly up-regulated in ESCC tissues and cells relative to their corresponding normal control. In addition, ZEB1-AS1 knockdown mediated by siRNA markedly suppressed the proliferation and invasion in vitro in EC9706 and TE1 cells, which was similar with ZEB1 siRNA treatment, coupled with EMT alterations including the up-regulation of E-cadherin level as well as the down-regulation of N-cadherin and vimentin levels. Notably, ZEB1-AS1 depletion dramatically down-regulated ZEB1 expression in EC9706 and TE1 cells, and ZEB1 overexpression obviously reversed the inhibitory effects of proliferation and invasion triggered by ZEB1-AS1 siRNA. ZEB1-AS1 shRNA evidently inhibited tumour growth and weight, whereas ZEB1 elevation partly recovered the tumour growth in ESCC EC9706 and TE1 xenografted nude mice. In conclusion, ZEB1-AS1 overexpression is tightly involved in the development and progression of ESCC, and it exerts the antitumour efficacy by regulating ZEB1 level in ESCC. ZEB1-AS1 and ZEB1 overexpressions were both related to TNM staging and lymph node metastasis as well as poor prognosis in ESCC. Yes In addition, ZEB1-AS1 knockdown mediated by siRNA markedly suppressed the proliferation and invasion in vitro in EC9706 and TE1 cells 31638344 ZEB1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-299-3p/E2F1 axis) Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay It was demonstrated that, in HCC tissues and cells, ZEB1-AS1 expression was markedly increased, and meanwhile, its high expression level is related to the unfavourable clinicopathologic indicators. In terms of mechanism, we discovered that ZEB1-AS1 could decoy miR-299-3p and upregulate E2F1 expression. It was demonstrated that, in HCC tissues and cells, ZEB1-AS1 expression was markedly increased, and meanwhile, its high expression level is related to the unfavourable clinicopathologic indicators. Yes ZEB1-AS1 overexpression facilitated HCC cell proliferation, migration and invasion, while its knockdown led to the opposite effects. 33788950 ZEB1-AS1 LncRNA Homo sapiens Diabetic Lung blood regulation[downregulating p53] qRT-PCR//Cell Apoptosis Assay//Western Blot The present data demonstrated that ZEB1-AS1 was downregulated in the plasma of patients with diabetic lung (DL) compared with diabetic patients without complications (~1.6-fold) and healthy controls (~2.4-fold), and downregulation of ZEB1-AS1 distinguished patients with DL from healthy controls. In conclusion, the present study demonstrated that ZEB1-AS1 was downregulated in patients with DL and regulates lung cancer cell apoptosis by downregulating p53. Yes ZEB1-AS1 in lung cells was downregulated by high glucose treatment, and overexpression of ZEB1-AS1 resulted in inhibited lung cancer cell apoptosis and downregulated p53. 33193839 ZEB1-AS1 LncRNA Homo sapiens Chlamydia cells Interaction(miR-1224-5p / MAP4K4 axis) Western Blot//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Bioinformatics Analysis//IF ZEB1-AS1 is a long non-coding RNA (lncRNA), which was up-regulated in persistent C. trachomatis infection in our previous work. Mechanically, interference ZEB1-AS1 caused an apparent down-regulation of the Bcl-2/Bax ratio and the repression of the mitochondrial membrane potential with the remarkable release of cytochrome c, resulting in the significant elevation level of caspase-3 activation. Meanwhile, the luciferase reporter assay confirmed that ZEB1-AS1 acted as a sponge for miR-1224-5p to target MAP4K4. Yes The results showed that ZEB1-AS1 was involved in the regulation of apoptosis, and targeted silencing of ZEB1-AS1 could increase the apoptosis rate of persistently infected cells. 35266440 ZEB1-AS1 LncRNA Rattus norvegicus Cerebral Ischemia/Reperfusion Injury CI/RI rats Interaction(HMGB1/TLR-4 signaling axis) In Vivo Experiment//Tunel//Western Blot In CI/RI rats, the expressions of ZEB1-AS1 and HMGB1 in the brain tissue increased progressively with the extension of reperfusion time, reaching the peak levels at 24 h followed by a gradual decline. ZEB1-AS1 overexpression significantly aggravated icognitive impairment and increased brain water content, albumin content in the CSF, and IL-1β and TNF-α levels in the CSF and serum in CI/RI rats (P < 0.05), while ZEB1-AS1 knockdown produced the opposite effects (P < 0.05 or 0.01). ZEB1-AS1 overexpression obviously increased the number of FJC-positive neurons in the cortex and enhanced the expressions of HMGB1 and TLR-4 in the rat models (P < 0.01); ZEB1-AS1 knockdown significantly reduced the number of FJC-positive neurons and lowered HMGB1 and TLR-4 expressions (P < 0.01). In SH-SY5Y cells with OGD/R, ZEB1-AS1 knockdown significantly suppressed cell apoptosis and lowered the expressions of HMGB1 and TLR-4 (P < 0.01). Yes ZEB1-AS1 overexpression significantly aggravated icognitive impairment and increased brain water content, albumin content in the CSF, and IL-1β and TNF-α levels in the CSF and serum in CI/RI rats (P < 0.05), while ZEB1-AS1 knockdown produced the opposite effects (P < 0.05 or 0.01). ZEB1-AS1 overexpression obviously increased the number of FJC-positive neurons in the cortex and enhanced the expressions of HMGB1 and TLR-4 in the rat models (P < 0.01); ZEB1-AS1 knockdown significantly reduced the number of FJC-positive neurons and lowered HMGB1 and TLR-4 expressions (P < 0.01). In SH-SY5Y cells with OGD/R, ZEB1-AS1 knockdown significantly suppressed cell apoptosis and lowered the expressions of HMGB1 and TLR-4 (P < 0.01). 36073211 ZDHHC8BP LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Regulation[ZDHHC8P1/miR-34a regulatory axis] CCK8//qRT-PCR//Wound Healing Assay " The results revealed that the ZDHHC8P1 expression was significantly higher in tumor tissues compared with paracancerous tissues (Figure 2A).We found that the expression lev_x0002_el of ZDHHC8P1 was markedly higher in CRC cell lines (SW480, SW620, HCT116, HT29 and LOVO) than FHC cells (Figure 1B). According to the results, this work uncovers a previously unappreciated ZDHHC8P1/miR-34a regulatory axis in controlling progression and metastasis of CRC and suggests that interfering with lncRNA-ZDHHC8P1 and miR-34a could be a viable approach to treat late-stage metastatic CRC patients." Additionally, the lncRNA ZDHHC8P1, an independent prognostic factor for overall survival, was increased in CRC and correlated positively with CRC progression. Yes Most importantly, through loss- and gain-of-function approaches, we showed that ZDHHC8P1 promotes progression and metastasis in vitro. 30840269 ZC3H12A-DT LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck primary OSCCs Interaction(miR-22-3p) qRT-PCR//Western Blot We found that LINC01137 was significantly upregulated in primary OSCCs . In addition, we found that miR-22-3p can directly target LINC01137 through interaction with a putative miR-22-3p-binding site present within the LINC01137 sequence. A significant negative correlation was observed between LINC01137 and miR-22-3p expression in primary OSCC specimens. Yes LINC01137 knockdown inhibited OSCC cell proliferation, migration and invasion, whereas LINC01137 overexpression induced opposite effects. LINC01137 upregulation along with p53 inhibition enhanced the malignant transformation of oral cells. 33797737 ZBTB20-AS1 LncRNA Homo sapiens Alzheimer Disease SH-SY5Y-AD cells Interaction(ZBTB20/GSK-3β/Tau pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//IHC//IF The results showed that expression of LncRNA ZBTB20-AS1 was significantly upregulated, while ZBTB20 was downregulated in SH-SY5Y-AD cells. ZBTB20 was the target gene of LncRNA ZBTB20-AS1. Overexpression of ZBTB20 or knockdown of LncRNA ZBTB20-AS1 inhibited SH-SY5Y-AD cells apoptosis and suppressed GSK3β/Tau pathway, and knockdown of ZBTB20-AS1 increased cell viability and decreased apoptosis. In conclusion, overexpression of ZBTB20-AS1 inhibited ZBTB20 expression and promoted GSK-3β expression and Tau phosphorylation, contributing to the development of AD. Yes Overexpression of ZBTB20 or knockdown of LncRNA ZBTB20-AS1 inhibited SH-SY5Y-AD cells apoptosis and suppressed GSK3β/Tau pathway, and knockdown of ZBTB20-AS1 increased cell viability and decreased apoptosis. 36502636 circHelz CircRNA Mus musculus Heart Injuries MI mouse and neonatal mouse ventricular cardiomyocytes (NMVCs) Interaction(miR-133a-3p/NLRP3 axis) In Vivo Experiment//Western Blot//Transfection//Tunel//qRT-PCR//Luciferase Report Assay We revealed that circHelz, a novel circRNA transcribed from the helicase with zinc finger (Helz) gene, was significantly upregulated in both the ischemic myocardium of MI mouse and neonatal mouse ventricular cardiomyocytes (NMVCs) exposed to hypoxia. Mechanistically, circHelz functioned as an endogenous sponge for miR-133a-3p via suppressing its activity. Overall, our results demonstrate that circHelz causes myocardial injury by triggering the NLRP3 inflammasome-mediated pro-inflammatory response and subsequent pyroptosis in cardiomyocytes by inhibiting miR-133a-3p function. Yes Overexpression of circHelz caused cardiomyocyte injury in NMVCs by activating the NLRP3 inflammasome and inducing pyroptosis, while circHelz silencing reduced these effects induced by hypoxia. Furthermore, knockdown of circHelz remarkably attenuated NLRP3 expression, decreased myocardial infarct size, pyroptosis, inflammation, and increased cardiac function in vivo after MI. Overexpression of miR-133a-3p in cardiomyocytes greatly prevented pyroptosis in the presence of hypoxia or circHelz by targeting NLRP3 in NMVCs. 34043986 ZEB1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-23c) CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay QRT-PCR results indicated ZEB1-AS1 was upregulated and miR-23c was downregulated in HCC tissues and cell lines. Dual luciferase reporter assay showed that miR-23c is a target of ZEB1-AS1, and ZEB1-AS1 was significantly negatively correlated with the miR-23c expression in HCC tissues. Yes ZEB1-AS1 knockdown hampered the proliferation and invasion of HCC cells. 33865414 ZEB1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-302b-EGFR-PI3K-AKT axis] qRT-PCR In the current study, we detected the significant upregulation of lncZEB1-AS1 in HCC tissues, and we found this expression to be associated with BM progression. In summary, our results provide novel evidence that lncZEB1-AS1 can promote HCC BM through a mechanism dependent upon the activation of PI3K-AKT signaling, thus highlighting a potentially novel therapeutic avenue for the treatment of such metastatic progression in HCC patients. Yes When we knocked down this lncRNA in HCC cells, we found that this significantly reduced their migratory, invasive, and metastatic activity both in vitro and in vivo. 32742459 XIST LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(microRNA-758/Rab16 ) qRT-PCR//Western Blot XIST was highly expressed in OS tissues and cells, but the opposite was seen for miR-758. XIST regulated miR-758 expression, and miR-758 regulated Rab16 expression in OS cells. Overexpression of Rab16 reversed the effects of miR-758 mimics on OS cell migration and invasion. Yes In OS cells, migration, invasion, and epithelial-mesenchymal transformation (EMT) was promoted by overexpression of XIST and miR-758 inhibitor, but were inhibited by XIST knockdown and miR-758 mimics. 34164475 ZEB2-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues Interaction[stabilizing ZEB2 ] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay Quantification data revealed that ZEB2‐AS1 was significantly up‐regulated in a large fraction of samples (Figure ​(Figure1B).1B).Enforced overexpression of ZEB2 largely attenuated the phenotypic changes resulted from ZEB2-AS1 inhibition except the impaired cell proliferation. ZEB2-AS1 was aberrantly overexpressed in a fraction of HNSCC samples. Its overexpression significantly associated with large tumour size, cervical node metastasis and reduced overall and disease-free survival. Yes Significantly reduced tumour growth and lung metastasis were observed in ZEB2-AS1-depleted cells in HNSCC xenograft animal models. 30950191 ZEB2-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction( miR-107/ SALL4 axis) qRT-PCR//Luciferase Report Assay We found that ZEB2-AS1 expression was distinctly upregulated in OS specimens and cell lines. Mechanistic investigation revealed that ZEB2-AS1 acted as a sponge for miR-107 and blocked the inhibition of spalt like transcription factor 4 (SALL4) via miR-107 in OS cells. Higher levels of ZEB2-AS1 in OS patients were associated with clinical stage, distant metastasis and unfavorable survivals. Yes Cellular experiments revealed that knockdown of ZEB2-AS1 inhibited proliferation and metastasis, and induced apoptosis in vitro. 33841645 ZEB2-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow Expression[highly expressed] qRT-PCR The results revealed that the expression of ZEB2-AS1 lncRNA was notably high and closely associated with adverse clinical outcomes in AML cases compared with the non-malignant cases, based on either modified Medical Research Council or European Leukemia Net risk stratification systems. Furthermore, the knockdown of ZEB2-AS1 lncRNA effectively inhibited AML cell invasion and migration, which was closely associated with the downregulation of ZEB2 and upregulation of E-cadherin expression. Collectively, although its independent prognostic value for survival was not rigorously determined, ZEB2-AS1 lncRNA may function as a candidate marker to improve conventional risk stratification systems and the evaluation of therapeutic responses for AML. The results revealed that the expression of ZEB2-AS1 lncRNA was notably high and closely associated with adverse clinical outcomes in AML cases compared with the non-malignant cases, based on either modified Medical Research Council or European Leukemia Net risk stratification systems. Univariate analyses indicated that patients with a higher expression of ZEB2-AS1 lncRNA had significantly shorter overall survival (OS) (P=0.036) and disease-free survival (DFS) rates (P=0.039) compared with patients with a lower expression of ZEB2-AS1 lncRNA. In addition, patients with a higher expression of ZEB2-AS1 lncRNA had a significant lower complete remission rate in response to induction by chemotherapy compared with patients with a lower expression of ZEB2-AS1 lncRNA (P=0.031). In cases with low levels of ZEB2-AS1 lncRNA, patients treated with allogenic hematopoietic stem cell transplantation had significantly longer OS and DFS rates compared with that of chemotherapy-treated patients (P=0.037 and P=0.049 respectively). Yes Furthermore, the knockdown of ZEB2-AS1 lncRNA effectively inhibited AML cell invasion and migration, which was closely associated with the downregulation of ZEB2 and upregulation of E-cadherin expression. 31186703 ZEB2-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML tissues or cells regulation[miR-122-5p/PLK1 axis] qRT-PCR//MTT//Luciferase Report Assay//Western Blot The results revealed that the expression levels of ZEB2?AS1 and PLK1 were upregulated, while those of miR?122?5p were downregulated in AML tissues and cells. On the whole, the findings of the present study demonstrate that ZEB2‑AS1 promotes cell proliferation and inhibits apoptosis, at least partly by targeting PLK1 mediated by miR‑122‑5p in AML cells. Yes The knockdown of ZEB2?AS1 inhibited proliferation and induced apoptosis in vitro, and inhibited tumor growth in vivo. 32700753 hsa_circ_0004381 CircRNA Mus musculus Alzheimer Disease Alzheimer disease mouse model, hippocampal neurons Interaction(miR-647/PSEN1 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//ELISA Assay We found that circ_0004381 was upregulated in Aβ1-42-treated hippocampal neurons.. Mechanistically, circ_0004381 regulated presenilin-1 (PSEN1) expression by absorbing miR-647. MiR-647 inhibition attenuated the effects of circ_0004381 knockdown. Yes Knockdown of circ_0004381 attenuated Aβ1-42-induced apoptosis, oxidative stress, and mitochondrial dysfunction in hippocampal neurons. Next, we induced microglia activation with lipopolysaccharide (LPS). The results of flow cytometry experiments showed that knockdown of circ_0004381 promoted microglial M2-type polarization and knockdown of circ_0004381 inhibited the production of inflammatory factors by microglia. Furthermore, knockdown of circ_0004381 improved cognitive function of male APPswe/PS1dE9 transgenic mice. 36409993 circFOXO3 CircRNA Mus musculus Lung Injury CS-exposed lungs and cigarette smoke extract (CSE)-treated murine alveolar epithelial cells Interaction(miR-214-3p/IKK-β) In Vivo Experiment//Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay//H&E Staining//ELISA//IHC//IF We noticed that circFOXO3 is upregulated in CS-exposed lungs and cigarette smoke extract (CSE)-treated murine alveolar epithelial cells. In addition, we identified miR-214-3p as a circFOXO3-targeted microRNA. MiR-214-3p overexpression exerted protective effects against pneumonic inflammation after CS exposure. Silencing of circFOXO3 downregulated IKK-β mRNA (miR-214-3p's target), resulting in the dysfunction of the NF-κB signaling pathway and attenuation of CSE-induced inflammatory-cytokine expression. Yes Knockdown of circFOXO3 attenuated the release of CXCL1 and IL-6 as well as inflammatory processes in the lungs of CS-exposed mice. 34789242 hsa_circ_0026344 CircRNA Mus musculus Pulmonary Fibrosis HBE cells Interaction(miR-21 / Smad7) RNA Pull-Down//Western Blot//Transfection//H&E Staining//qRT-PCR//Luciferase Report Assay//Microarray conclusion, the results reveal that, in CS-induced pulmonary fibrosis, circRNA_0026344, via exosomal miR-21 regulation of Smad7, is involved in aberrant cross-talk of epithelium-fibroblasts.  Yes conclusion, the results reveal that, in CS-induced pulmonary fibrosis, circRNA_0026344, via exosomal miR-21 regulation of Smad7, is involved in aberrant cross-talk of epithelium-fibroblasts. 33961985 ZEB2-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Interaction( miR-145) Transfection//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Bioinformatics Analysis A significantly increased level of lncRNA ZEB2-AS1 with a fold change of 3.86 was found in osteosarcoma tissues compared with control tissues (P < 0.001).Significantly increased ZEB2-AS1 expression was found in osteosarcoma cells, while decreased levels of miR-145 were confirmed in osteosarcoma tissues and cell lines compared to controls. Moreover, a negative correlation was found between the expression level of ZEB2-AS1 and miR-145 in osteosarcoma tissues (R2 = 0.71, P < 0.01). The Chi-square test revealed that lncRNA ZEB2-AS1 expression in osteosarcoma was significantly different according to radiology classification (P = 0.018), TNM stage (P = 0.000) and survival status (P = 0.005). Yes ZEB2-AS1 knockdown resulted in decreased osteosarcoma cell proliferation, increased apoptosis and reduced migration. In addition, negative regulation of miR-145 by ZEB2-AS1 in osteosarcoma cells was also observed, and the effects of ZEB2-AS1 on osteosarcoma cells were found to be regulated by miR-145. 32826416 ZEB2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction[Suppressing PTEN] qRT-PCR//RIP//ChIP ZEB2-AS1 was upregulated in NSCLC tissues and cell lines. lncRNA ZEB2-AS1 is upregulated in NSCLC, which elevates the viability and malignant degree of NSCLC cells by downregulating PTEN, thus aggravating the progression of NSCLC. Yes Knockdown of ZEB2-AS1 suppressed proliferative, migratory, and invasive properties of NCI-H1650 and HCC827 cells. 31695021 ZEB2-AS1 LncRNA Homo sapiens Pre-Eclampsia pregnancies Regulation[miR-149/PGF axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Downregulation of lncRNA ZEB2-AS1 was detected in placentas from patients with PE when compared with those from normal pregnancies.In sum, we identified that ZEB2-AS1 was a novel aberrantly expressed lncRNA in the placentas of PE patients and lncRNA ZEB2-AS1 modulated trophoblastic cell line HTR-8/SVneo's proliferative and invasive potentials via targeting the miR-149/PGF axis. Yes Moreover, ZEB2-AS1 upregulation markedly promoted proliferative, migratory, and invasive potentials in HTR-8/SVneo cells, while knockdown of ZEB2-AS1 had the opposite effects. 31148230 circHIPK3 CircRNA Mus musculus Diabetic Nephropathies diabetic mice Interaction(diabetic mice) RNA Pull-Down//In vivo experiment//Flow Cytometry//qRT-PCR//FISH//RNA-seq//Luciferase Report Assay//ChIP Herein, we discovered that circHIPK3 expression is markedly elevated in cultured podocytes under high-glucose (HG) conditions and glomeruli of diabetic mice, which is closely associated with podocyte injury in DKD.Mechanistically, circHIPK3 facilitates the enrichment of fused in sarcoma (FUS) on the ectodysplasin A2 receptor (EDA2R) promoter, resulting in the upregulation of EDA2R expression and activation of apoptotic signaling. Yes Functionally, lentivirus-mediated knockdown of circHIPK3 dramatically suppresses HG-induced podocyte apoptosis in vitro. Therapeutically, silencing circHIPK3 by adeno-associated virus-mediated RNA interference ameliorates podocyte injury and albuminuria in STZ-induced diabetic mice. 36263181 mmu_circ_0005019 CircRNA Mus musculus Myocardial Infarction cardiac fibroblasts of 10-day-old neonatal mice C57BL/6 Interaction(miR-499-5p) Transfection//CCK8//qRT-PCR//FISH//RIP//migration assay//Cell Apoptosis Assay//Luciferase Report Assay We recently found a circRNA hsa_circ_0099734 was significantly differentially expressed in the AF patients atrial tissues compared to paired control. In cardiac fibroblasts, mmu_circ_0005019 showed inhibitory effects on cell proliferation and migration. Mechanistically, mmu_circ_0005019 exerted biological functions by acting as a miR-499-5p sponge to regulate the expression of its target gene Kcnn3. Yes In cardiac fibroblasts, mmu_circ_0005019 showed inhibitory effects on cell proliferation and migration. In cardiomyocytes, overexpression of mmu_circ_0005019 promoted Kcnd1, Scn5a and Kcnn3 expression. Knockdown of mmu_circ_0005019 inhibited the expression of Kcnd1, Kcnd3, Scn5a and Kcnn3. 34154526 circEsyt2 CircRNA Mus musculus Vascular Remodeling-Related Diseases aortae of 3-month-old C57BL/6J and ApoE–/– mice fed with a regular chow diet and ApoE–/– mice fed with a high‑fat diet for 3 months Interaction(PCBP1-U2AF65) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//FISH//IF//circRNA-seq//Cell Apoptosis Assay//Cell Proliferation Assay//Tansfection//Transwell Assay Here, we investigated a previously identified circRNA, circEsyt2, whose expression is known to be upregulated during vascular remodeling. Furthermore, the silencing of circEsyt2 in vivo reduced neointima formation, while circEsyt2 overexpression enhanced neointimal hyperplasia in the injured carotid artery, confirming its role in vascular remodeling. circEsyt2 was found to directly interact with polyC-binding protein 1 (PCBP1), an RNA splicing factor, and regulate PCBP1 intracellular localization. Yes Loss- and gain-of‑function mutation analyses in vascular smooth muscle cells (VSMCs) revealed that circEsyt2 enhanced cell proliferation and migration and inhibited apoptosis and differentiation. Furthermore, the silencing of circEsyt2 in vivo reduced neointima formation, while circEsyt2 overexpression enhanced neointimal hyperplasia in the injured carotid artery, confirming its role in vascular remodeling. 34907911 circPrkcsh CircRNA Mus musculus Spinal Cord Injuries SCI mice Interaction(JNK/p38 MAPK pathway) In Vivo Experiment//Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//H&E Staining//IF Quantitative Real-time PCR and Fluorescence in situ hybridization analysis revealed that circPrkcsh was upregulated in the microglia of SCI mice when compared to sham-operated mice. Our research provides a better understanding of the mechanism of circPrkcsh in SCI and demonstrates that the circPrkcsh/miR-488/Mekk1 axis is a promising regulatory method for the treatment of SCI. Yes Gain- or loss-of-function experiments and in vivo assays further indicated that circPrkcsh promotes microglia M1 polarization both in vivo and in vitro. 34751973 circFBXW4 CircRNA Mus musculus Liver Cirrhosis liver tissues regulation[miR-18b-3p/FBXW7 axis] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//FISH We found that circFBXW4 downregulated in liver fibrogenesis.circFBXW4 may act as a suppressor of HSCs activation and HF through the circFBXW4/miR-18b-3p/FBXW7 axis. Yes Enforcing the expression of circFBXW4 inhibited HSCs activation, proliferation and induced apoptosis, attenuated mouse liver fibrogenesis injury and showed anti-inflammation effect. 32308754 hsa_circ_0003091 CircRNA Mus musculus Lung Injury LPS-treated mice and PMVECs Interaction(miR-149/Smad2 axis) Western Blot//Tunel//qRT-PCR//RNA-seq//Luciferase Report Assay//H&E Staining//ELISA//IF Compared to healthy subjects, 35 circRNAs were upregulated and 9 circRNAs were downregulated in sepsis patients. The top 10 differentially expressed circRNAs were selected for validation and has_circ_0003091 was selected. The ALI mice presented significantly elevated has_circ_0003091 (mmu_circ_0015268). The functional analysis revealed that mmu_circ_0015268 contributed to the pulmonary injury, cell apoptosis, inflammatory responses, and endothelial activation in the ALI murine model. On the other hand, silencing mmu_circ_0015268 showed protective effects in LPS-treated mice and PMVECs. Furthermore, mmu_circ_0015268 sponged miR-149 to upregulate the expression of its target Smad2. In summary, we demonstrated that has_circ_0003091 might be a novel target for the management and treatment of sepsis-induced ALI. Yes The functional analysis revealed that mmu_circ_0015268 contributed to the pulmonary injury, cell apoptosis, inflammatory responses, and endothelial activation in the ALI murine model. 35700140 ZEB1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[repressing ID1] Western Blot//Flow Cytometry//qRT-PCR//Colony Formation Assay//Transwell Assay ZEB1-AS1 was significantly up-regulated in NSCLC tissues compared with normal samples. ZEB1-AS1 overexpression was significantly associated with advanced tumor, lymph node, and metastases (TNM) stage and tumor size, as well as poorer overall survival. Yes Moreover, ZEB1-AS1 knockdown inhibited NSCLC cell proliferation and migration, and promoted cell apoptosis. 30626729 ZEB1-AS1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cell lines interaction[ sponging miR-141-3p] qRT-PCR//Luciferase Report Assay In this current study, we found that the expression of ZEB1-AS1 in colorectal cancer tissues and cell lines was significantly upregulated, and positively correlated with advanced stage of colorectal cancer.Collectively, ZEB1-AS1 may contribute to colorectal cancer cell proliferation by sponging miR-141-3p. Yes Knocking down of ZEB1-AS1 inhibited the proliferation of colorectal cancer cells. 32669962 ZEB1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[MiR-205/YAP1 Axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay LncRNA ZEB1-AS1 and YAP1 was upregulated in CRC tissues.Long non-coding RNA ZEB1-AS1 silencing could inhibit cell proliferation and induce apoptosis of colorectal cancer via regulating miR-205 and YAP1. Yes Knockdown of ZEB1-AS1 inhibited cell viability and induced apoptosis in CRC cell line SW480 and HCT116 which could be reversed by overexpression of YAP1. 32190742 circHECTD3 CircRNA Mus musculus Ischemic Stroke brain tissues regulation[microRNA-133b/TRAF3 pathway] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Tunel The results showed that the expression of circ-HECTD1 and tumor necrosis factor receptor-associated factor 3 (TRAF3) was remarkably up-regulated, while miR-133b was down-regulated in oxygen-glucose deprivation (OGD)-induced HT22 cells and mouse middle cerebral artery occlusion (MCAO) model. Taken together, circ-HECTD1 knockdown inhibited the expression of TRAF3 by targeting miR-133b, thereby attenuating neuronal injury caused by cerebral ischemia. Yes circ-HECTD1 knockdown relieved OGD-caused neuronal cell death in vitro. Simultaneously, circ-HECTD1 knockdown improved cerebral infarction volume and neuronal apoptosis in MCAO mice. 33148417 circTLK1 CircRNA Mus musculus Ischemic Stroke brain tissues Interaction[miR-335-3p/TIPARP] Western Blot//qPCR//CCK8//FISH//Luciferase Report Assay The levels of circTLK1 were significantly increased in brain tissues in a mouse model of focal cerebral ischemia and reperfusion.Furthermore, circTLK1 functioned as an endogenous miR-335-3p sponge to inhibit miR-335-3p activity, resulting in the increase of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible poly (ADP-ribose) polymerase expression and a subsequent exacerbation of neuronal injury. Clinical studies confirmed increased levels of circTLK1 in the plasma of patients with acute ischemic stroke (59 males and 12 females). Yes Knockdown of circTLK1 significantly decreased infarct volumes, attenuated neuronal injury, and improved neurological deficits. 31311824 hsa_circ_0057558 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease NAFLD models Interaction(miR-206/ROCK1/AMPK signaling ) In Vivo Experiment//Western Blot//Transfection//RIP//qRT-PCR//Luciferase Report Assay//RNA-seq//H&E Staining//Oil Red O Staining//ELISA//IHC Circ_0057558 was elevated while miR-206 was reduced in both in vivo and in vitro NAFLD models.miR-206 directly bound with ROCK1 3'-UTR and suppressed lipogenesis and TG secretion through targeting ROCK1/AMPK signaling. Circ_0057558 directly interacted with miR-206 to disinhibit ROCK1/AMPK signaling. Yes Knockdown of circ_0057558 or overexpression of miR-206 inhibited lipogenesis, TG secretion and expression of lipogenesis-related proteins. ROCK1 knockdown reversed the effects of circ_0057558 overexpression. Injection of miR-206 mimics significantly ameliorated NAFLD progression in vivo. 34446693 XIST LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tumors Interaction(miR-221-3p/ MGMT) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay Their expression was measured in tumor tissues and corresponding non-tumor tissues by quantitative real-time PCR (qRT-PCR), which revealed that XIST was weakly expressed in HCC cells and tumors, while miR-221-3p was overexpressed. Collectively, our findings reveal that XIST blocks the development of HCC through miR-221-3p-targeted regulation of MGMT. Yes Complete knockdown of XIST enhanced HCC cell proliferation and migration and inhibited apoptosis, as observed by MTT, transwell, and flow cytometry experiments, respectively. Animal studies validated that XIST knockdown induces tumor growth in vivo. In contrast, upregulation of XIST in HCC cells suppressed their proliferation and migration, stimulated apoptosis, and retarded the growth rate of tumors in vivo. 35723009 XIST LncRNA Homo sapiens Colorectal Neoplasms cell lines Interaction(miR-125b-2-3p axis) Western Blot//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay Mechanistically, miR-125b-2-3p was absorbed by long noncoding RNA (lncRNA) XIST regulating WEE1 G2 checkpoint kinase (WEE1) expression. The upregulation of miR-125b-2-3p inhibited the proliferation and epithelial-mesenchymal transition (EMT) of CRC induced by lncRNA XIST. Yes Mechanistically, miR-125b-2-3p was absorbed by long noncoding RNA (lncRNA) XIST regulating WEE1 G2 checkpoint kinase (WEE1) expression. The upregulation of miR-125b-2-3p inhibited the proliferation and epithelial-mesenchymal transition (EMT) of CRC induced by lncRNA XIST. 33666372 XIST LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cells Interaction(microRNA-338-3p/PAX5 axis) qRT-PCR//Luciferase Report Assay//Western Blot XIST and PAX5 expression were increased, and miR-338-3p expression was decreased in colorectal cancer tissues and cells. XIST knockdown significantly repressed cell proliferation, migration and invasion, and accelerated apoptosis in colorectal cancer cells. Interestingly, XIST directly downregulated miR-338-3p expression to increase PAX5 level. As expected, XIST knockdown inhibited colorectal cancer cell growth by modulating miR-338-3p expression. Furthermore, miR-338-3p suppressed cell growth via downregulation of PAX5 level in colorectal cancer cells. Yes XIST knockdown significantly repressed cell proliferation, migration and invasion, and accelerated apoptosis in colorectal cancer cells. Interestingly, XIST directly downregulated miR-338-3p expression to increase PAX5 level. As expected, XIST knockdown inhibited colorectal cancer cell growth by modulating miR-338-3p expression. 32826710 XIST LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(microRNA-448/GRHL2) In Vivo Experiment//RNA Pull-Down//Western Blot//Colony Formation Assay//Flow Cytometry//qRT-PCR//MTT//IHC//Transwell Assay XIST and GRHL2 expressed highly whereas miR-448 expressed lowly in CRC tissues and cells. miR-448 upregulation reversed the role of XIST elevation in CRC cells. XIST particularly bound to miR-448, and miR-448 targeted GRHL2. Knockdown of XIST upregulates miR-448 to impede malignant behaviors of CRC cells via inhibiting GRHL2. Yes XIST or GRHL2 downregulation, or miR-448 elevation suppressed the malignant behaviors of CRC cells in vitro, and downregulated XIST or upregulated miR-448 also inhibited the tumor growth in vivo. 35725976 XIST LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues and cell lines Expression[highly expressed] qRT-PCR XIST was up-regulated in EOC tissues and cell lines. The expression of XIST was closely related to the tumor grade, distant metastasis, and FIGO stage in the EOC patients. The Cox regression analysis showed that high XIST expression was an independent predictor of prognosis in patients with EOC. Yes In in vitro experiments, reducing XIST expression significantly suppressed cell proliferation, migration and invasion in EOC cells. 31564909 XIST LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and cell lines Regulation[miR-106b-5p/P21 axis] RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//FISH//MTT//Luciferase Report Assay//Microarray//Transwell Assay In this study, we found that XIST was down-regulated in RCC tissues and cells.We further found that XIST could directly interact with miR-106b-5p and increase the expression of P21. Thus, XIST positively regulated the expression of P21 through sponging miR-106b-5p, and played a tumor suppressor role in RCC. Moreover, we found that curcumin could regulate XIST/miR-106b-5p/P21 axis in RCC cells. Our study exhibits the role of XIST as a miRNA sponge in RCC and supports the potential application of XIST in RCC therapy. Yes Overexpression of XIST significantly suppressed cell proliferation and induced cell G0/G1 arrest in vitro and inhibited tumor growth in vivo. 30717973 XIST LncRNA Homo sapiens Osteoarthritis cartilage Interaction[miR-1277-5p] qRT-PCR//Western Blot In the present study, XIST was revealed to be upregulated in OA specimens and in articular chondrocytes (ACs) derived from OA tissue (AC/OA) and interleukin‑1β (IL‑1β)‑treated ACs. In conclusion, the present study suggests that XIST promotes MMP‑13 and ADAMTS5 expression, indicating ECM degradation, by functioning as a ceRNA of miR‑1277‑5p in OA. Yes Loss‑of‑function experiments demonstrated that downregulation of XIST suppressed the degradation of the ECM in AC/OA and AC/IL‑1β‑5.0 cells. 31198977 XIST LncRNA Homo sapiens Osteoarthritis OA cartilage tissues regulation[miR-149-5p/DNMT3A axis] qRT-PCR XIST was expressed at a high level in OA cartilage tissues and IL-1β-treated chondrocytes.This study discovers the XIST/miR-149-5p/DNMT3A axis in regulating OA evolution, which is beneficial for understanding the molecular pathomechanism and can lay a good foundation for targeted therapy of OA treatment. Yes XIST knockdown promoted cell viability but restrained cell apoptosis and extracellular matrix (ECM) protein degradation in IL-1β-treated chondrocytes. 32521454 XIST LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[ sponging miR-200b-3p] CCK8//qRT-PCR//Colony Formation Assay//RIP By comparing with XIST expression in adjacent tissues, the XIST expression level was significantly higher in HCC samples. Further experiments showed that miR-200b-3p was directly targeted by XIST. Yes Moreover, functional assays showed that the cell growth ability of HCC cells was inhibited after XIST was silenced in vitro, and tumor formation was inhibited after XIST was silenced in vivo. 31799653 XIST LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer cells and tissues Interaction(miR-335/BCL2L2 axis） Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The inhibition of XIST can inhibit the proliferation invasion and migration of human ovarian cancer cells.  Yes The inhibition of XIST can inhibit the proliferation invasion and migration of human ovarian cancer cells.  34090463 hsa_circ_0044235 CircRNA Mus musculus Arthritis, Rheumatoid FLSs Interaction(MiR-135b-5p-SIRT1 axis) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//ELISA//Bioinformatics Analysis Hsa_circ_0044235 and SIRT1 expressions were suppressed in RA patients and the two were positively correlated. Overexpressed hsa_circ_0044235 attenuated joint inflammation, cell apoptosis, and joint damage, reduced foot pad thickness, clinical case scores, inhibited the NLRP3-mediated pyroptosis pathway but promoted SIRT1 expression in CIA mice. Overexpressed hsa_circ_0044235 inhibited caspase-1 content and the NLRP3-mediated pyroptosis pathway. Moreover, hsa_circ_0044235 promoted SIRT1 expression by sponging miR-135b-5p in FLSs. Additionally, the effect of overexpressed hsa_circ_0044235 on FLSs was reversed by miR-135b-5p mimic and siSIRT1, while the effect of siSIRT1 was reversed by miR-135b-5p inhibitor. Hsa_circ_0044235 regulated NLRP3-mediated pyroptosis through miR-135b-5p-SIRT1 axis to regulate the development of RA. Yes Overexpressed hsa_circ_0044235 attenuated joint inflammation, cell apoptosis, and joint damage, reduced foot pad thickness, clinical case scores, inhibited the NLRP3-mediated pyroptosis pathway but promoted SIRT1 expression in CIA mice. 34097558 XIST LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-149-3p/FOXP3 ) Flow Cytometry//MTT//Colony Formation Assay//Western Blot XIST and FOXP3 were upregulated, whereas miR-149-3p was downregulated in OC tissues and cells.In SKOV3 cells upon treatment of overexpressed XIST or reduction of miR-149-3p, there exhibited an opposite tendency. Based on online website prediction, dual luciferase reporter gene, and RNA pull-down assays, we found that there was a negative relationship between XIST and miR-149-3p, and miR-149-3p downregulated FOXP3 expression. High XIST expression indicated a poor prognosis of OC. Yes Inhibition of XIST or elevation of miR-149-3p repressed proliferation, invasion, migration, and colony formation ability, and promoted apoptosis and cell cycle arrest of HO-8910 cells. 33542185 XIST LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-106a) qRT-PCR//RNA Pull-Down//Luciferase Report Assay Notably, OC tissues and cells exhibited low XIST levels and high miR-106a levels. miR-106a targeted the XIST. Also, the miR-106a overexpression reversed the inhibitory effects of XIST on OC cell proliferation and apoptosis. Yes The XIST upregulation decreased the OVCAR3 and CAOV3 cell proliferation and inversely promoted cell apoptosis. 33400246 XIST LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction[targeting miR-133a] CCK8//qRT-PCR//Wound Healing Assay The present study demonstrated that XIST was significantly upregulated in bladder cancer tissues compared with that in adjacent normal tissues. A luciferase assay suggested that XIST binds to its predicted binding site in miR-133a. In addition, it was identified that miR-133a was significantly downregulated in bladder cancer, and its expression levels were inversely correlated with those of XIST in bladder cancer tissues. Furthermore, loss- and gain-of-function experiments indicated that miR-133a acted as a downstream effector in XIST-mediated bladder cancer cell proliferation and migration. Yes High expression of XIST was significantly associated with tumour progression and poor prognosis of patients with bladder cancer. An in vitro experiment indicated that knockdown of XIST significantly reduced the proliferation and migration of bladder cancer cells. 31602223 XIST LncRNA Homo sapiens Urinary Bladder Neoplasms Interaction[XIST-TET1-p53] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry Mechanistically, we confirmed that lncRNA XIST participates in bladder cancer by downregulating p53 via binding to TET1. In conclusion, our research revealed the potential role of XIST-TET1-p53 regulatory network in bladder cancer. Yes We found that knockdown of XIST suppressed cell migration and proliferation in vitro. 30362292 XIST LncRNA Homo sapiens Urinary Bladder Neoplasms BCSC-like cells Interaction [miR-200c] qRT-PCR//IHC The results indicated that miR-200c overexpression and XIST knockdown could inhibit cell clone formation, self-renewal ability and EMT in BCSC-like cells. miR-200c knockdown could restore the tumour growth inhibition caused by XIST knockdown. Yes The results indicated that miR-200c overexpression and XIST knockdown could inhibit cell clone formation, self-renewal ability and EMT in BCSC-like cells. miR-200c knockdown could restore the tumour growth inhibition caused by XIST knockdown. 29559853 XIST LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells and tissues Interaction(miR-133a-5p/VEGFB) qRT-PCR XIST was upregulated in OSCC cells and tissues, which predicted a poorer prognostic outcome in OSCC patients. miR-133a-5p was identified as a downstream target of XIST, which was downregulated in OSCC tissues. miR-133a-5p mediated the effect of XIST by targeting VEGFB. VEGFB overexpression rescued the inhibitory effects of XIST silencing on cell growth, invasion and migration. Yes Silencing XIST inhibited the growth and invasion of OSCC cells and triggered apoptosis. 35912960 XIST LncRNA Homo sapiens Osteosarcoma OS tissues and their matched adjacent normal bone,cell lines(KHOS-240S，SaOS2，MG-63，SOSP-9607,U2OS,hFOB1.19) Expression[highly expressed] Western Blot//Migration Assay//CCK8//qRT-PCR//Invasion Assay we measured the expression of XIST in OS cell lines and our results indicated that the expression level of XIST was relatively high in four OS cell lines,The results suggested that XIST was significantly increased in the cancerous tissues compared with the adjacent normal samples In addition, lncRNA XIST may be used as an independent risk factor for the overall survival of patients with osteosarcoma. Yes Knockdown of lncRNA XIST inhibited cell proliferation, induced cell apoptosis and arrested the cell cycle. The inhibition of lncRNA XIST may also suppress cell migration and invasion in vitro. 30655762 XIST LncRNA Homo sapiens Osteosarcoma OS tissues regulation[miR-153-SNAI1 axis] qRT-PCR In the current study, we demonstrate that XIST is significantly upregulated in 30 pairs of OS tissues compared with their matched adjacent nontumor tissues by the quantitative reverse transcription polymerase chain reaction. In conclusion, this work demonstrates that lncRNA-XIST promotes the oxidative stress-induced OS cell invasion, migration, and EMT through the miR-153/SNAI1 pathway, presenting lncRNA-XIST as a promising therapeutic target for treating metastatic OS. Yes Overexpression of XIST significantly induced the invasion, migration, and the epithelial-to-mesenchymal transition (EMT) phenotype. 32515520 circHIPK3 CircRNA Mus musculus Diabetic Cardiomyopathies DCM mice Interaction(miR-29b-3p) In Vivo Experiment//Western Blot//RIP//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//IHC//IF circHIPK3 contributes to increased myocardial fibrosis during DCM by functioning as a competing endogenous RNA that upregulates Col1a1 and Col3a1 expression through suppressing miR-29b-3p. Yes Knockdown of circHIPK3 was found to attenuate myocardial fibrosis and enhance cardiac function in DCM mice. In addition, silencing of circHIPK3 could suppress proliferation of cardiac fibroblasts treated with angiotensin II. 33398455 XIST LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Interaction(miR-34a-5p/PDL1 axis) Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//ELISA//Invasion Assay XIST was up-regulated in lung cancer tissues, while miR-34a-5p was the opposite. XIST up-regulated the expression of PDL1 by targeting miR-34a-5p, thereby affecting the viability, apoptosis, migration, and invasion of lung cancer cells. In the co-culture system, XIST targeted miR-34a-5p to inhibit cytokines secretion and promote the expression of immunosuppressive molecules. Yes XIST up-regulated the expression of PDL1 by targeting miR-34a-5p, thereby affecting the viability, apoptosis, migration, and invasion of lung cancer cells. 35067156 XIST LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma Forty-two pairs of ESCC tissues and corresponding adjacent noncancerous tissues Interaction(miR-129-5p/CCND1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Bioinformatics Analysis//Flow Cytometry//qRT-PCR//CCK8//RIP//Luciferase Report Assay//Invasion Assay//Transwell Assay Our results indicated that XIST was upregulated and miR-129-5p was downregulated in ESCC. Moreover, XIST directly interacted with miR-129-5p and repressed miR-129-5p expression. MiR-129-5p mediated the regulatory effect of XIST on ESCC cell progression in vitro, and XIST promoted CCND1 expression by sponging miR-129-5p. Yes XIST silencing or miR-129-5p overexpression repressed cell cycle progression, proliferation, migration, invasion, and promoted the apoptosis in ESCC cells. Additionally, XIST silencing inhibited tumor growth in vivo. 33345719 hsa_circ_0031672 CircRNA Mus musculus Myocardial Reperfusion Injury I/R rat model and hypoxia/re-oxygenation (H/R)-treated H9C2 cells Interaction(circRNA_0031672/miR-21-5p/PDCD4 signaling pathway) In Vivo Experiment//Transfection Yes CircRNA_0031672 knockdown increased miR-21-5p expression, but repressed PDCD4 expression, indicating that circRNA_0031672 competitively bound to miR-21-5p and prevented it from targeting PDCD4 mRNA. 35136398 circTLK1 CircRNA Mus musculus Myocardial Reperfusion Injury myocardial IRI mouse model regulation[miR-214/RIPK1-mediated TNF signaling pathway] Western Blot//Tunel//RIP//qRT-PCR//Luciferase Report Assay circTLK1 was an up-regulated circRNA found in a myocardial IRI mouse model.Taken together, our study revealed an up-regulated circRNA, circTLK1, could exacerbate myocardial IRI via targeting miR-214/RIPK1-mediated TNF signaling pathway, which may provide therapeutic targets for treatment. Yes Mice with silencing circTLK1 significantly alleviated the impaired cardiac function indexes and decreased infarct area, thus attenuating the pathogenesis of myocardial IRI. Knockdown of circTLK1 dramatically decreased cardiomyocytes apoptosis, which was determined by apoptosis-related proteins. 32445866 XLOC_138 LncRNA Homo sapiens Multiple Myeloma blood Interaction[NF-κB pathway] FISH//Western Blot We found that XLOC_013703 was significantly decreased in CD138 positive plasma cells and serum of MM patients compared to normal controls, and the decreased XLOC_013703 expression was correlated with β2-MG, serum-free light chain (s-FLC) and revised international staging system.XLOC_013703 was involved in MM cell survival and proliferation via nuclear factor-κB pathway which represents a potential therapeutic target for MM. Yes Overexpression of XLOC_013703 inhibited the proliferation of U266 cells and blocked the cell cycle in G1 stage, thus contributing to MM cell apoptosis. 30861305 XLOC_006390 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cell lines Interaction(miR-296/ONECUT2 Axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Migration Assay//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//IHC//Invasion Assay//Transwell Assay The results revealed significant (P < 0.05) overexpression of lncRNA-XLOC_006390 in colorectal cancer tissues and cell lines, and the transcript levels increased with the advancement of the disease. Moreover, its high expression was shown to be associated with poor patient survival. Silencing of lncRNA-XLOC_006390 in colorectal cancer cells significantly (P < 0.05) suppressed their viability via onset of apoptosis and restricted cancer cell migration and invasion. In vivo tumor growth was significantly (P < 0.05) inhibited under lncRNA-XLOC_006390 repression. LncRNA-XLOC_006390 was shown to sponge the expression of miR-296-3p which in turn acted via post-transcriptional suppression of ONECUT 2 transcription factor to regulate the growth of colorectal cancer. The results revealed significant (P < 0.05) overexpression of lncRNA-XLOC_006390 in colorectal cancer tissues and cell lines, and the transcript levels increased with the advancement of the disease. Yes Silencing of lncRNA-XLOC_006390 in colorectal cancer cells significantly (P < 0.05) suppressed their viability via onset of apoptosis and restricted cancer cell migration and invasion. In vivo tumor growth was significantly (P < 0.05) inhibited under lncRNA-XLOC_006390 repression. 35874630 XLOC_005950 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction( hsa-miR-542-3p/PFKM) qRT-PCR//Luciferase Report Assay//Western Blot The results demonstrated that lncRNA XLOC_005950 expression was upregulated in OS tissues and cells. Taken together, the results of the present study suggest that lncRNA XLOC_005950 knockout may inhibit the progression of OS via hsa-miR-542-3p-mediated regulation of PFKM expression. Yes Functional experiments indicated that lncRNA XLOC_005950 knockout decreased PFKM activity, the intracellular glucose and lactic acid content, and cell proliferation, while increasing apoptosis of OS cells. Furthermore, lncRNA XLOC_005950 knockout upregulated hsa-miR-542-3p expression and downregulated PFKM expression. Overexpression of hsa-miR-542-3p suppressed PFKM expression. 34386091 XLOC_001659 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cell lines Interaction[miR-490-5p/PIK3CA] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The results of RT-qPCR showed that the expression of lncRNAXLOC_001659 was upregulated in ESCC cells. Knockdown of lncRNA XLOC_001659 inhibits proliferation and invasion of ESCC cells via regulation of miR-490-5p/PIK3CA, suggesting that it may play a role in ESCC tumorigenesis and progression. Yes CCK-8 assay showed that knockdown of lncRNAXLOC_001659 significantly inhibited ESCC cell proliferation. Colony formation and Transwell invasion assays showed that knockdown of lncRNAXLOC_001659 or overexpression of miR-490-5p significantly inhibited ESCC cell growth and invasion. 31754291 XLEC1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues Interaction[MBP-1] RNA Pull-Down//Transwell Assay//Wound Healing Assay//FISH//RIP//RNA-seq//Colony Formation Assay//ChIP Here, by using RNA-seq we report the identification of a new X chromosome-linked lncRNA (lnc-XLEC1) that is aberrantly downregulated during the development of endometrial carcinoma (EC).In addition, lnc-XLEC1 had inhibitive effects that may result from its collaboration with MBP-1 during the suppression of the c-Myc expression and the negative regulating of the Cdk/Rb/E2F pathway. Yes The overexpression of lnc-XLEC1 reduces the migration and proliferation of EC cells. 30698832 XIST LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[NFκB pathway] qRT-PCR//Luciferase Report Assay//RIP//ChIP High expression of XIST and EPHA1 was observed in GC.Further, the functional role of XIST in GC with the involvement of NFκB pathway was also analyzed. Yes In addition, silencing of XIST inhibited GC progression in vitro and in vivo. Overexpressed XIST and EPHA1 yielded a reversed effect on cell proliferation and invasion. 33199830 XIST LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues regulation[microRNA-132,PXN] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP Our results demonstrated that expression of lncRNA XIST and PXN was significantly elevated while the expression of miR-132 was significantly reduced in gastric cancer tissues. Meanwhile, rescue experiments suggested that silencing of lncRNA XIST could reverse the tumor-promotive effect exerted by either miR-132 inhibitor or PXN. Yes Moreover, silencing of lncRNA XIST and up-regulation of miR-132 could suppress tumor formation ability, cell proliferation and migration, but enhanced apoptosis in gastric cancer. However, the overexpression of PXN achieved the opposite tumor-promotive effect. 33154189 XIST LncRNA Homo sapiens Stomach Neoplasms cell lines interaction[targeting miR-337] qRT-PCR//Transwell Assay//Western Blot Compared with that in GES-1 cells, XIST expression was significantly up-regulated in AGS and HGC-27 cells. Therefore, we speculated that XIST regulates JAK2 by competing with miR-337 as a competitive endogenous lncRNA in GC. Yes The proliferation, invasion and migration of GC cells were simultaneously inhibited by XIST knockdown, and the relationship between XIST and miR-337 was confirmed by bioinformatics analysis. 32830093 XIST LncRNA Homo sapiens Stomach Neoplasms MGC803 and BGC823 cells Interaction(XIST/miR-185/TGF-β1 axis) Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay We observed that XIST was increased in MGC803 and BGC823 cells compared to human normal gastric epithelial GES-1 cells. It was also shown that miR-185 was decreased in GC cell lines. Silencing XIST can inhibit the growth of GC cells and bioinformatics analysis was performed to confirm the correlation between XIST and miR-185.Interestingly, a negative correlation was indicated between XIST and miR-185 in GC cells. In addition, TGF-β1 was predicted as a target gene of miR-185. miR-185 can modulate TGF-β1 expression negatively in vitro. Moreover, we found that sh-XIST inhibited GC development via decreasing TGF-β1 by upregulating miR-185 in vitro. Therefore, we speculated that XIST can act as a competing endogenous lncRNA (ceRNA) to regulate TGF-β1 by sponging miR-185 in GC. Yes Silencing XIST can inhibit the growth of GC cells and bioinformatics analysis was performed to confirm the correlation between XIST and miR-185. 29053187 XIST LncRNA Homo sapiens Breast Neoplasms breast cancer cells and tissues interaction[binding to miR-125b-5p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay XIST was found to be overexpressed in breast cancer tissues and cells, which was accompanied by miR-125b-5p downregulation and NLRC5 upregulation. In conclusion, the lncRNA XIST promotes the malignancy of breast cancer cells partly by competitively binding to miR-125b-5p, which then led to increased NLRC5 expression. Yes XIST knockdown significantly repressed cell proliferation, anti-apoptosis, migration, and invasion activities in breast cancer cells, and the loss of miR-125b-5p had a similar effect. 32774715 XIST LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[ sponging miR-16 and regulating CDK8] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay We noted that XIST in NSCLC tumor tissue and cell lines was significantly up-regulated.In vivo study further revealed a oncogenic effect of XIST. In addition, we conducted bioinformatics analysis and luciferase activity assay to find out the potential target miR of XIST and the potential target gene of miR-16 which is CDK8. Yes XIST over-expression promoted the proliferation and migration, meantime, increased the proportion of cells in the S phase in NSCLC cell line A549 and H1299. Meantime, knockdown of XIST showed the opposite effects. 31632587 XIST LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Regulation[miR-744/RING1 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The expression of lncRNA XIST was significantly up-regulated in NSCLC tissues.Mechanically, it was indicated that XIST could serve as an endogenous competitive RNA modulating miR-744, leading to the miR-744/RING1 signaling pathway inhibition and Wnt/β-catenin signaling pathway activation. Taken together, it was confirmed here that XIST overexpression is associated with tumor progression phenotype and the newly discovered XIST/miR-744/RING1 axis, which could serve as a potential biomarker and therapeutic target for NSCLC. In addition, overexpression of XIST was positively correlated with the advanced clinical status of tumors, as well as poor overall survival and DFS. Yes A tumor suppressive effect was presented via functional knockdown of lncRNA XIST. Up-regulation of XIST enhanced the proliferation, migration, and invasion ability of NSCLC cells both in vivo and in vitro 31292221 XIST LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-142-5p/PAX6 Axis] CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay XIST was elevated in NSCLC, and XIST knockdown suppressed cell proliferation, migration, invasion and induced apoptosis in vitro as well as repressed tumor growth in vivo.XIST suppresses cell tumorigenicity in human NSCLC by regulating miR-142-5p/PAX6 axis, which indicates a novel insight into the pathogenesis of NSCLC and lays a foundation for the molecular therapy of NSCLC. Yes XIST was elevated in NSCLC, and XIST knockdown suppressed cell proliferation, migration, invasion and induced apoptosis in vitro as well as repressed tumor growth in vivo. 32581553 TTN-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues/cells regulation[miR-139-5p/ZEB1 axis] qRT-PCR In the current paper, we observed that TTN-AS1 expression was significantly upregulated in breast cancer tissues/cells compared with those that are healthy. That is, TTN-AS1 promoted proliferation and invasion of breast cancer cells by interaction with the miR-139-5p/ZEB1 axis. Yes TTN-AS1 enhanced the proliferation, migration, invasion, and epithelial-mesenchymal transformation of breast cancer cells. 32100921 TTN-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-491-5p/ZNF503 Axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The levels of TTN-AS1 and ZNF503 were up-regulated, while miR-491-5p expression was reduced in NSCLC tissues and cells. Inhibition of TTN-AS1 hindered cell proliferation, migration, invasion and EMT in NSCLC cells by modulating miR-491-5p/ZNF503 axis, providing a promising biomarker for NSCLC treatment. Yes Knockdown of TTN-AS1 or ZNF503 suppressed cell proliferation, migration, invasion and EMT in NSCLC cells.Furthermore, TTN-AS1 induced tumor growth in vivo. 32669856 SNHG3 LncRNA Homo sapiens Osteosarcoma cell lines Interaction[sponging miR-196a-5p ] qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay As a result, the expression of SNHG3 was dramatically increased in OS tissue as compared with the adjacent normal tissues.In conclusion, lncRNA SNHG3 promoted cell growth by sponging miR-196a-5p and indicated a poor prognosis in OS patients. High expression of SNHG3 was associated with tumor size and acted as an independent prognostic factor of poor survival in OS patients. Yes Knockdown of SNHG3 inhibited cell viability and colony formation, but its overexpression reversed these effects. 30791797 SOD2 LncRNA Homo sapiens Ovarian Neoplasms OC tissues regulation[p53 signaling pathway] Western Blot//ISH//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The expression of lncRNA H19 GClnc1 was markedly higher in OC samples than the related normal tissues.To sum up, LncRNA GClnc1 contributes to the progression of OC by regulating p53 signaling pathway. Yes In addition, the lncRNA GClnc1 overexpression promoted the cell proliferation and migration in vitro. 33207861 SOX21-AS1 LncRNA Homo sapiens Wilms Tumor nephroblastoma tissues and cell lines Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay In the present study, we first found that SOX21-AS1 expression was elevated in nephroblastoma tissues and cell lines compared with adjacent normal tissues and normal human embryonic kidney cell line, respectively. Moreover, we observed nephroblastoma patients with large tumor size, advanced National Wilms Tumor Study (NWTS) stage or unfavorable histopathological type, and patients that had higher SOX21-AS1 expression levels than nephroblastoma patients with small tumor size, early NWTS stage or favorable histopathological type. Yes The in vitro studies suggested that knockdown of SOX21-AS1 suppressed nephroblastoma cell proliferation and colony formation, and induced cell-cycle arrest through up-regulating p57 expression. 30992391 SOX21-AS1 LncRNA Homo sapiens Neuronal Injury SH-SY5Y cells Interaction(miR-7-5p and IRS2) Western Blot//Transfection//Tunel//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay In our research, the expression of lncRNA SRY-box transcription factor 21 antisense divergent transcript 1 (SOX21-AS1) was up-regulated in 1-methyl-4-phenylpyridinium (MMP+)-treated SH-SY5Y cells. In sum up, our study demonstrated a new regulatory network consisted of SOX21-AS1, miR-7-5p and IRS2 in SH-SY5Y cells, supplying with a better comprehension about the pathogenic mechanism of PD. Yes In addition, SOX21-AS1 depletion weakened the cell injury induced by MMP+. Moreover, SOX21-AS1 knockdown decreased Reactive Oxygen Species (ROS) generation and levels of TNF-α, IL-1β and IL-6, but increased SOD activity. However, SOX21-AS1 up-regulation led to opposite results. 33421490 SOX13 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction( circSOX13-miR-3194-3p-MAPRE1 axis) Western Blot//Transfection//qPCR//Flow Cytometry//PCR//IF In this work it was found that compared with adjacent normal tissues, circSOX13 and the microtubule-associated protein RP/EB family member 1 (MAPRE1) were signally up-regulated in NSCLC while miR-3194-3p was signally lowered. To conclude, this work clarified the carcinogenic impact of circSOX13-miR-3194-3p-MAPRE1 axis on NSCLC and DDP resistance. Yes Pulmonary function tests (PETs) revealed that knocking down circSOX13 or overexpressing miR-3194-3p inhibited NSCLC proliferation, invasion and migration but promoted its apoptosis. The promoting effect of overexpressing circSOX13 on NSCLC was reversed via knocking down MAPRE1. 34709968 SOS1-IT1 LncRNA Homo sapiens Endometrial Neoplasms TCGA(550 tumor tissue samples and 35 normal samples) Interaction(HIF-1α) Cell Proliferation Assay//qRT-PCR//Luciferase Report Assay Interestingly, we found SOS1-IT1 was overexpressed in tumor tissues, and closely correlated with clinicopathological parameters of EC. The expression level of SOS1-IT1 was significantly increased under hypoxia condition. Additionally, the important hypoxia regulatory factor HIF-1α can directly bind SOS1-IT1 promoter region, and affect its expression level. SOS1-IT1 is clinically relevant in EC and promotes EC cell growth Yes SOS1-IT1 is clinically relevant in EC and promotes EC cell growth 34637090 SORBS2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Expression(lower expressed) CCK8//qRT-PCR//Bioinformatics Analysis//Transwell Assay The expression of AC093797.1 decreased in HCC tissues and cell lines, and patients with low expressed AC093797.1 had poor overall survival (OS). Compared with the control group, 710 differentially expressed genes (243 upregulated genes and 467 downregulated genes) were filtered via RNA-sequencing, which mainly enriched in amino acid metabolism, extracellular matrix structure constituents, cell adhesion molecules cams, signaling to Ras, and signaling to ERKs. The expression of AC093797.1 decreased in HCC tissues and cell lines, and patients with low expressed AC093797.1 had poor overall survival (OS). Yes AC093797.1 overexpression impeded HCC cell proliferation, invasion, and migration in vitro and suppressed tumor growth in vivo. 34925460 SOD2 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Regulation[inhibiting p53 signaling pathway] Western Blot//CCK8//qRT-PCR//RIP//ChIP The expression of GClnc1 in colorectal cancer tissues was significantly higher than that of para-cancerous tissues.RNA pull-down and RIP experiments revealed that there was a specific interaction between GClnc1 and p53. Moreover, qRT-PCR and Western blot analysis indicated that the expression level of p53 was not affected after over-expression of GClnc. However, the expressions of p21 and BAX were remarkably decreased. The Luciferase reporter gene assay revealed that GClnc1 over-expression markedly weakened the Luciferase activity of p53. Meanwhile, ChIP experiments demonstrated that GClnc1 up-regulation affected the binding condition of p53 to p21. Western blot analysis showed that knockdown of p53 reversed the increased mRNA level of p21 as well as BAX. Furthermore, p53 down-regulation significantly weakened cell viability and colony formation ability caused by knockdown of GClnc1. Meanwhile, GClnc1 expression in T3 and T4 tumors was markedly higher than that of T1 and T2. The survival analysis revealed that patients with a higher level of GClnc1 showed remarkably lower overall survival than those with lower expression of GClnc1. Yes After knocking down GClnc1 in SW620 cells, the viability and proliferation abilities were conspicuously decreased. Meanwhile, the expression level of GClnc1, as well as the viability and colony formation ability of cells, were significantly increased after over-expression of GClnc1 in HCT116 cells. 31298323 SOD2 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues regulation[recruiting FOXC2,activating the NF-κB/Snail signaling ] ISH//qRT-PCR//FISH GClnc1 was significantly overexpressed in EOC tissues,GClnc1 promoted NOTCH1 transcription by recruiting FOXC2, thereby activating the NF-κB/Snail signaling and promoting EOC cell growth and metastasis. Yes GClnc1 was significantly overexpressed in EOC tissues, and knockdown of GClnc1 inhibited cell viability and promoted apoptosis.Finally, in vivo experiments demonstrated that GClnc1 knockdown suppressed the growth and metastasis of SKOV3 and OVC1 cells in vivo. 33338479 SOD2 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Interaction[LIN28B/let-7a/MYC pathway] qRT-PCR In this study, we identified an lncRNA, gastric cancer-associated lncRNA1 (GClnc1), which was in high abundance in bladder cancer tissues. Mechanistically, we first found that GClnc1 bound to LIN28B and promoted the expression of myelocytomatosis proto-oncogene (MYC) through the LIN28B/let-7a/MYC pathway. In this study, we identified an lncRNA, gastric cancer-associated lncRNA1 (GClnc1), which was in high abundance in bladder cancer tissues and its expression was related to poor survival rates in patients with bladder cancer. Yes In vitro and in vivo assays showed that GClnc1 significantly promoted cell proliferation, metastasis, and invasiveness in bladder cancer. 31298933 SOX21-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC cells Interaction(SOX21/USP10) In Vivo Experiment//RNA Pull-Down//Western Blot//Tunel//Flow Cytometry//qRT-PCR//FISH//IF//RIP//Colony Formation Assay//EdU Staining//Transwell Assay SOX21-AS1 possessed a high expression level in PC cells. SOX21-AS1 positively regulated its nearby gene SRY-box transcription factor 21 (SOX21) at post-transcriptional level. Through mechanism assays, we uncovered that SOX21-AS1 sponged SOX21-AS1 to elevate SOX21 mRNA and recruited ubiquitin-specific peptidase 10 (USP10) to deubiquitinate and stabilize SOX21 protein. Moreover, signal transducer and activator of transcription 6 (STAT6) could transcriptionally activate SOX21-AS1 and SOX21 expression. Yes SOX21-AS1 absence suppressed PC cell proliferation, migration, stemness and epithelial-mesenchymal transition (EMT) while elevated cell apoptosis. 36335356 SOD2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues Interaction(miR-2355-5p/CAMSAP2) RNA Pull-Down//Western Blot//Transfection//qPCR//RIP//PCR//IP//IF We found elevated expression of circSOD2 and CAMSAP2 while reduced expression of miR-2355-5p in NSCLC tumor tissues. Silencing or overexpression of CircSOD2 resulted in increased or decreased expression of miR-2355-5p, respectively. Mechanically, we showed that silencing of CircSOD2 and overexpression of miR-2355-5p resulted in the reduced rate of NSCLC cell proliferation. Inhibition of miR-2355-5p reversed the changes induced via silencing of CircSOD2. MiR-2355-5p binds to the CircSOD2 promoter and triggered its stimulation, which further activated circSOD2 expression. Yes CircSOD2 suppression impaired lung cancer cell growth, cell migration, prohibited cell cycle progression, and in vivo tumor growth by targeting miR-2355-5p expression in NSCLC tissues. Meanwhile, increased expression of CAMSAP2 reversed the changes stimulated by the elevated level of miR-2355-5p in NSCLC progression. 35188072 hsa_circ_0006232 CircRNA Homo sapiens laryngeal squamous cell carcinoma human LSCC cells (AMC-HN-8 and TU686) Regulation(EZH2 ) In Vivo Experiment//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay We found that compared with human bronchial epithelial cells, hsa_circ_0006232 was highly expressed in human LSCC cells (AMC-HN-8 and TU686). Hsa_circ_0006232 promoted the expression of enhancer of zeste homolog 2 (EZH2) and repressed the expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN). Fused in sarcoma (FUS) interacted with hsa_circ_0006232 and EZH2, and FUS promoted the stabilization of EZH2. Hsa_circ_0006232 inhibited PTEN by promoting FUS expression. Yes Moreover, hsa_circ_0006232 promoted proliferation, migration and invasion of AMC-HN-8 and TU686 cells.Moreover, we constructed a tumor xenograft model by injection of AMC-HN-8 cells with hsa_circ_0006232 knockdown, and we found that hsa_circ_0006232 deficiency decreased tumor growth in mice. 34437823 hsa_circ_0067934 CircRNA Homo sapiens laryngeal squamous cell carcinoma LSCC tissues and cells interaction[sponging miR-1324] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ_0067934 expression was remarkably upregulated in LSCC tissues and cells.Mechanism analysis revealed that circ_0067934 regulated LSCC development by sponging miR-1324. High level of circ_0067934 was significantly related to tumor size, lymph node status, and distant metastasis of LSCC. Yes In vitro experiments showed that down-regulation of circ_0067934 inhibited proliferation and migration of LSCC cells. 32373969 SOCS2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[SOCS2-AS1/miR-1264/SOCS2 axis] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We showed that SOCS2-AS1 was lowly expressed in CRC tissues and cells.Taken together, our results identified a novel regulatory loop in which SOCS2-AS1/miR-1264/SOCS2 axis suppresses CRC progression. SOCS2-AS1 downregulation predicted a poor prognosis in patients with CRC. Yes SOCS2-AS1 overexpression significantly suppressed CRC cell proliferation, colony formation, EdU incorporation, cell-cycle, migration and invasion in vitro while SOCS2-AS1 knockdown led to an opposite phenotype. SOCS2-AS1 overexpression inhibited CRC growth and metastasis in vivo. 32437330 SOCS2-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues Regulation(AURKA) In Vivo Experiment//RNA Pull-Down//qRT-PCR//RIP//FISH We found that SOCS2-AS1 was downregulated in EC tissues. Its reduced expression was correlated with advanced clinical stage and poor prognosis. Mechanistically, SOCS2-AS1 bound to Aurora kinase A (AURKA) and increased its degradation through the ubiquitin-proteasome pathway. We found that SOCS2-AS1 was downregulated in EC tissues. Its reduced expression was correlated with advanced clinical stage and poor prognosis. Yes Forced expression of SOCS2-AS1 suppressed EC cell proliferation and induced cell-cycle arrest and apoptosis. 33824269 SOCS2-AS1 LncRNA Homo sapiens Mucocutaneous Lymph Node Syndrome blood regulation[SOCS2-AS1/miR-324-5p/CUEDC2 axis ] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining SOCS2-AS1 was highly expressed in serum and tissues of KD patients.SOCS2-AS1 upregulates CUEDC2 via inhibiting miR-324-5p to promote the progression of HUVECs in KD, providing new insights for KD treatment. Yes SOCS2-AS1 depletion repressed the proliferation of HUVECs, whereas it facilitated apoptosis. 32688371 circCRKL CircRNA Homo sapiens Leukemia, Myelogenous, Chronic, BCR-ABL Positive BCR-ABL+ cells Interaction(miR-877-5p ) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis Here, we determined circCRKL, which derives from CML-relevant gene CRKL, is over-expressed in BCR-ABL+ cells. Intriguingly, we observed that circCRKL has a considerable impact on the expression level of BCR-ABL. Mechanistically, circCRKL could behave like a decoy for miR-877-5p to enhance the BCR-ABL level, allowing BCR-ABL+ cells to maintain viability. Yes Then we noticed knocking down circCRKL using shRNA lentivirus dampens the proliferation of BCR-ABL+ cells both in vitro and in vivo, and augments susceptibility of resistant cells to IM. 36058922 SOX21-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues regulation[GATA6 ,TSPAN8 ] RNA Pull-Down//Western Blot//Transwell Assay//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//ChIP SOX21-AS1 was observed to be highly expressed in lung adenocarcinoma tissues.Silencing of SOX21-AS1 and inhibiting its binding to GATA6 downregulate TSPAN8 and thereby exert anti-oncogenic effects in lung adenocarcinoma. Yes The overexpression of SOX21-AS1, GATA6 or TSPAN8 obviously enhanced cell biological functions in lung adenocarcinoma. Meanwhile, SOX21-AS1 interacted with GATA6 which bound to TSPAN8 promoter and promoted TSPAN8 expression, which further enhanced cell colony formation, proliferation and invasion, and also activated ERK signaling pathway. 32698071 SOX21-AS1 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[ SOX21-AS1/miR-144-3p/PAK7 axis ] qRT-PCR//Luciferase Report Assay//RIP SOX21-AS1 was upregulated in glioma tissues and cells. These results indicated that SOX21-AS1/miR-144-3p/PAK7 axis played an oncogenic role in glioma cells by regulating Wnt/β-catenin pathway, which suggests a rational therapeutic strategy for glioma. Yes Moreover, in vitro, SOX21-AS1 knockdown repressed proliferation, migration, invasion and enhanced apoptosis in glioma cells. In vivo, SOX21-AS1 knockdown suppressed tumor growth in mice. 31973536 hsa_circ_0002814 CircRNA Homo sapiens Pre-Eclampsia placenta and plasma of patients with preeclampsia, HTR8 and JEG3 cells. Interaction(miR-210/ FUS/VEGF axis) RNA Pull-Down//Western Blot//Transfection//Invasion Assay//qRT-PCR//FISH//EdU Staining The expression of circ-0002814 was decreased in the placenta and plasma of patients with preeclampsia. circ_0002814-regulated Notch1 and CPEB2 by interaction with miR-210 and also regulated FUS/VEGF axis in HTR8 and JEG3 cells. Yes The ectopic expression of circ-0002814 promoted the invasion and proliferation of HTR8 cells compared to the control group (p < 0.05). Silencing circ-0002814 suppressed the invasion and proliferation of JEG3 cells compared to the control group (p < 0.05). 35644449 SOX2-OT LncRNA Homo sapiens Laryngeal Neoplasms cell lines regulation[suppressing miR-654] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay The data demonstrated that SOX2-OT level were significantly increased in the laryngeal cell lines. In summary, the present study reported that knockdown of SOX2-OT could suppress cell proliferation, migration and invasion, and induce apoptosis in laryngeal cancer by targeting miR-654. Yes Furthermore, SOX2-OT silencing markedly promoted apoptosis and suppressed the proliferation, migration and invasion of TU-177 cells. 32266028 SOX2-OT LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Interaction(miR-942-5p and PI3K/Akt) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//Wound Healing Assay//RIP//qRT-PCR//IF//Luciferase Report Assay//Cell Apoptosis Assay//Microarray//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Here, we demonstrated that PAI-1 is high expressed in TNBC and promotes TNBC cells tumorigenesis. Using microarray analysis of lncRNA expression profiles, we identified a lncRNA SOX2-OT, which is induced by PAI-1 and could function as an oncogenic lncRNA in TNBC. Mechanistic analysis demonstrated that SOX2-OT acts as a molecular sponge for miR-942-5p to regulate the expression of PIK3CA, ultimately leading to activating PI3K/Akt signaling pathway and promoting TNBC metastasis. Taken together, our findings suggest that SOX2-OT regulates PAI-1-induced TNBC cell metastasis through miR-942-5p/PIK3CA signaling and illustrate the great potential of developing new SOX2-OT-targeting therapy for TNBC patients. Yes Mechanistic analysis demonstrated that SOX2-OT acts as a molecular sponge for miR-942-5p to regulate the expression of PIK3CA, ultimately leading to activating PI3K/Akt signaling pathway and promoting TNBC metastasis. 34997317 SOX2-OT LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Regulation[miR-146b-5p/HNRNPA2B1 pathway ] qRT-PCR In our study, SOX2-OT was notably elevated in NPC samples and cells.At last, we discovered that SOX2-OT regulated NPC progression by targeting miR-146b-5p/HNRNPA2B1 pathway, which may provide more innovative targets for the treatment of patients with NPC. Further, a high expression level of SOX2-OT was correlated with poor clinical outcomes of NPC. Yes Results from loss-of-function experiments suggested that knockdown of SOX2-OT repressed cell proliferation, arrested cell cycle, facilitated cell apoptosis, and inhibited cell metastasis of NPC. 31099048 SOX2-OT LncRNA Homo sapiens Glioblastoma GBM cell line Interaction(miR-192-5p/RAB2A axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Bioinformatics Analysis Western blot and qRT-PCR were employed to analyze the activity of extracellular-signal-regulated kinase (ERK) signaling pathway. SOX2-OT expression was higher in GBM cell lines than in normal cells. Mechanism assays revealed that SOX2-OT could sponge miR-192-5p. Moreover, RAB2A was certified to be the target gene of miR-192-5p. Overexpression of RAB2A reversed the repressive function of SOX2-OT knockdown on GBM cell growth. Yes SOX2-OT knockdown repressed proliferation and promoted apoptosis of GBM cells. 34470582 SOX2-OT LncRNA Homo sapiens Multiple Myeloma MM cell lines and patient samples regulation[microRNA-143-3p/c-MET axis] CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay In the present study, elevated SOX2OT levels are reported in MM cell lines and patient samples as compared to normal plasma cells (nPCs) and healthy donors, respectively.These data support that SOX2OT promotes MM progression through regulating the miR-144-3p/c-MET axis, suggesting that SOX2OT might be as a potential therapeutic target for MM. Yes Knock-down of SOX2OT led to a significant inhibition of cell proliferation, arrested cells at G0/G1 phase and induced cell apoptosis in MM samples in vitro, as well as slowed the growth of tumours in vivo. 32198978 SOX2-OT LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues Interaction[EZH2-mediated H3K27me3 ] qRT-PCR In this study, we found that SOX2-OT expression was increased and negatively correlated with PTEN expression in LSCC tissues. Collectively, our findings demonstrate that SOX2-OT inhibits PTEN expression to facilitate LSCC development through EZH2-mediated H3K27me3. Yes Furthermore, SOX2-OT overexpression promoted LSCC cell proliferation, migration, invasion, and suppressed cell apoptosis in vitro, as well as facilitated the in vivo tumorigenicity. By contrast, SOX2-OT silencing exerted the opposite effect. 30811870 SOX2-OT LncRNA Homo sapiens Prostatic Neoplasms PC tissues and cells Regulation[miR-369-3p/CFL2 axis] Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining According to the data from this study, SOX2-OT expression was conspicuously elevated in PC tissues and cells. To sum up, SOX2-OT accelerates cell proliferation and migration by targeting miR-369-3p/CFL2 axis in PC. Yes Silenced SOX2-OT could repress PC cell proliferation and migration. 31623830 SOX2-OT LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells regulation[ miR-452-5p/HMGB3 axis,Wnt/β-catenin signaling pathway] Flow Cytometry//qRT-PCR//Luciferase Report Assay//RIP SOX2-OT and HMGB3 were upregulated, whereas miR-452-5p was downregulated in PCa tissues and cells. SOX2-OT downregulation limited PCa cell growth and metastasis by regulating miR-452-5p/HMGB3 axis and inactivating Wnt/β-catenin signaling pathway, which might offer lncRNA-directed diagnosis and therapy for PCa. Yes Knockdown of SOX2-OT inhibited PCa cell growth and metastasis. MiR-452-5p could directly bind to SOX2-OT and its knockdown reversed the inhibitory effects of SOX2-OT interference on growth and metastasis of PCa cells. 32407168 circEIF5 CircRNA Homo sapiens Psoriasis psoriasis tissues Regulation(NF-κB and STAT3) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining In this study, we identified that hsa_circ_0033469 (circEIF5) was highly expressed in psoriasis tissues compared with the normal skin. These moderating effects of circEIF5 were associated with the activating of the NF-κB and STAT3 signalling pathways. Moreover, NF-κB and STAT3 inhibition abrogated circEIF5-induced promotion of cell proliferation and chemokine secretion. These results indicated that through NF-κB and STAT3 signalling pathways, circEIF5 regulated the proliferation and chemokine secretion of HaCat cells and contributed to the pathogenesis of psoriasis, which might become a potent target for psoriasis treatment. Yes By using a approach of knockdown and overexpression of circEIF5, we showed that circEIF5 could promote proliferation by facilitating the G1/S transition and increase secretion of chemokines in HaCat cells. 35288970 SOX2-OT LncRNA Homo sapiens Diabetic Nephropathies streptozotocin-induced DN mice and high glucose-induced mouse mesangial cells Regulation(Akt/mTOR) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//IHC//EdU Staining//IF lncRNA SOX2OT was markedly down-regulated both in streptozotocin-induced DN mice and high glucose-induced mouse mesangial cells.Additionally, an obvious inhibition of Akt/mTOR was also observed with lncRNA SOX2OT overexpression, which was then further verified in vivo. Yes Moreover, overexpression of lncRNA SOX2OT was able to diminish the suppression of autophagy and alleviate DN-induced renal injury. Functionally, CCK-8 and EDU assays indicated that lncRNA SOX2OT overexpression significantly suppressed the proliferation and fibrosis of mesangial cells. 34238205 SOX21-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cell lines regulation[miR-520a-5p/ORMDL3 axis] qRT-PCR In our research, SOX21-AS1 had a high expression in TNBC cell lines. Further, data from rescue assays revealed that SOX21-AS1 could regulate the malignancy of TNBC via miR-520a-5p/ORMDL3 axis. Yes The functional experiments showed that knockdown of SOX21-AS1 obviously restrained cell proliferation, migration, invasion, and epithelial-mesenchymal transition process and promoted cell apoptosis. 32277517 circVAPA CircRNA Homo sapiens Psoriasis psoriatic lesional tissues, keratinocytes Interaction(miR-125b-5p/sirt6 axis) Western Blot//Transfection//qPCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//ELISA Herein our findings showed increased expression of circVAPA and Sirt6 and decreased level of miR-125b-5p in psoriatic lesional tissues and M5-stimulated keratinocytes.CircVAPA participate in the progression of psoriasis through miR-125b-5p/sirt6 axis by regulating proliferation and inflammation of keratinocytes, highlighting a potential therapeutic target for psoriasis. Yes Mechanistically, circVAPA knockdown significantly suppressed the promotion of M5 on cell viability, proliferation, and inflammation of HaCaT cells. 36592530 SOX2-OT LncRNA Homo sapiens Esophageal Neoplasms cancer cells Expression(highly expressed) Cell Proliferation Assay//Transfection Our findings showed that ESCC tumorspheres overexpress SOX2OT gene along with other stemness genes (SOX2, OCT4A, and Nanog) compared to their original cancer cells. Yes RNAi experiments indicated that SOX2OT knockdown can suppress the stemness-related gene expression, sphere formation ability (both size and number), and docetaxel resistance as three of the main cancer stem cell characteristics of tumorspheres. 36548179 SOX21-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues regulation[PI3K/AKT Signaling Pathway] qRT-PCR SOX21-AS1 was highly expressed in BC, and the p-PI3K and p-AKT levels were also high. Silencing BC expression can inhibit the proliferation, invasion, migration, and EMT of cells by inhibiting the PI3K/AKT signaling pathway, which may be a new target for diagnosis and treatment. Yes Cell experiments showed that inhibiting SOX21-AS1 expression could inhibit the proliferation, invasion, migration, and EMT of BC cells, and up-regulating its expression could promote the proliferation, invasion, migration, and EMT of ovarian cancer cells. The tumor-forming experiment in nude mice was consistent with the results in vitro. 33173334 SOX21-AS1 LncRNA Homo sapiens Breast Neoplasms Breast cancer tissues and cell lines (MCF-7, MDA-MB-231, CSC-MCF-7, CSC-MDA-MB-231) Interaction(Hippo pathway) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay we first confirmed that the expression level of SOX21-AS1 is increased in breast cancer tissues and cell lines (MCF-7, MDA-MB-231, CSC-MCF-7, CSC-MDA-MB-231), especially in BCSCs. We also observed that SOX21-AS1 inhibited the Hippo pathway Yes We demonstrated that SOX21-AS1 promotes the stemness of CSC-MCF-7 cells through western blot detection of stemness-related proteins, as well as side population and sphere formation assays. Overexpression of SOX21-AS1 enhanced the proliferation, migration and invasion of CSC-MCF-7 cells. 33103351 SOX21-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cells Interaction(miR-24-3p/PIM2 axis) In Vivo Experiment//Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay SOX21-AS1 expression levels were high in lung cancer tissues and cells. In contrast, the amount of miR-24-3p bound to SOX21-AS1 was relatively low in cancerous tissues and cells. PIM2 was targeted by miR-24-3p and showed increased levels in tumor tissues and cells. Yes The knockdown of SOX21-AS1 decreased cell proliferation, activated apoptosis, and promoted cell migration and invasion 34511042 SOX21-AS1 LncRNA Homo sapiens Osteosarcoma cell lines regulation[miR-7-5p/IRS2 Regulatory Network] RNA Pull-Down//Western Blot//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay SOX21-AS1 had high expression in OS, and its presence accelerated OS cell proliferation, migration and invasion.SOX21-AS1 enhances IRS2 level by absorbing miR-7-5p, so as to boost the progression of OS. Yes Rescue experiments certified that the enhancement of IRS2 would neutralize the inhibition of SOX21-AS1 depletion on OS cell proliferation and metastasis. 33341286 SOX21-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction[sponging miR-7/VDAC1] qRT-PCR In this study, we first reported that SOX21-AS1 expression was significantly upregulated in both CC tissues and cell lines. Furthermore, our data showed that microRNA-7 (miR-7) interacted with SOX21-AS1 by directly targeting the miRNA-binding site in the SOX21-AS1 sequence, and quantitative real-time polymerase chain reaction results showed overexpression of SOX21-AS1 decreased the levels of miR-7 in CC cells. Moreover, we confirmed that miR-7 directly targeted the 3'-untranslated region of voltage dependent anion channel 1 (VDAC1). High expression of SOX21-AS1 was found to be significantly correlated with Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis and depth of cervical invasion. Further clinical assay confirmed that high SOX21-AS1 expression was associated with shorter overall survival and could be used as a potential prognostic biomarker for CC patients. Yes Functional investigation showed that knockdown of SOX21-AS1 suppressed CC cells proliferation, migration, and invasion, as well as epithelial to mesenchymal transition progress.Final in vitro assay suggested that in CC cells with SOX21-AS1, VDAC1 overexpression resulted in an increase of cell proliferation, migration, and invasion. 30912129 circHIPK3 CircRNA Homo sapiens Leukemia, Myelogenous, Chronic, BCR-ABL Positive blood Expression[highly expressed] qRT-PCR We found that circHIPK3 was significantly upregulated in peripheral blood mononuclear cells (PBMC) and serum samples from CML compared with healthy controls. Yes Further loss-function experiments suggested the oncogenic role of circHIPK3 in CML. 31307197 hsa_circ_0043610 CircRNA Homo sapiens Pre-Eclampsia PE placental tissues and cells Interaction(miR-558/RYBP) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Invasion Assay//CCK8//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Compared with normal placental controls, the increased expression of circ_0043610 and RYBP and the decreased miR-558 expression were detected in PE placental tissues. Mechanistically, circ_0043610 acted as a miR-558 sponge, and miR-558 bound to RYBP. Besides, miR-558 introduction remitted circ_0043610-mediated effects in JEG-3 and HTR-8/SVneo cells. Moreover, RYBP participated in the regulation of miR-558 on trophoblast cell behaviors. Further, the ectopic expression of circ_0043610 led to RYBP upregulation through miR-558. Yes The overexpression of circ_0043610 led to decreased trophoblast cell proliferation, invasion, and migration but increased cell apoptosis. 35908953 SOX2-OT LncRNA Homo sapiens Parkinson Disease SH-SY5Y cells Interaction(miR-942-5p/NAIF1 signal axis ) qRT-PCR//MTT//Western Blot The expression levels of lncRNA SOX2-OT and NAIF1 were increased, and miR-942-5p expression was decreased in SH-SY5Y cells following MPP+ treatment. Overall, lncRNA SOX2-OT-mediated regulation of oxidative stress, inflammation, and neuronal apoptosis were directly controlled by the miR-942-5p/NAIF1 signal axis in MPP+-induced SH-SY5Y cells. Yes In addition, MPP+ treatment reduced SH-SY5Y cell viability, increased apoptosis; increased cleaved caspase-3 protein expression and cleaved caspase-3/caspase-3 ratio; enhanced lactate dehydrogenase viability; increased tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and reactive oxygen species, and decreased superoxide dismutase activity in SH-SY5Y cells were inhibited by SOX2-OT-siRNA, and these inhibitions were reversed by miR-942-5p inhibitor. 34607512 hsa_circ_0001805 CircRNA Homo sapiens Non-alcoholic Fatty Liver Disease FFA-challenged primary hepatocytes, HFD-fed mice and NAFLD patients Interaction(miR-106a-5p/miR-320a and ABCA1/CPT1 axis) qRT-PCR//Luciferase Report Assay//Western Blot CircRNA_0001805 expression was downregulated in FFA-challenged primary hepatocytes, HFD-fed mice and NAFLD patients. CircRNA_0001805 targeted miR-106a-5p/miR-320a, which served as an upstream inhibitor of ABCA1/CPT1 and collaboratively regulated NAFLD progression. Yes Overexpressed circRNA_0001805 attenuated NAFLD development by suppressing lipid metabolism disorder and inflammation. 34789275 circXPO1 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive lungs of CS-exposed mice and the CS extract (CSE)-treated alveolar epithelial cell line Interaction(miR-23b-3p/TAB3) In Vivo Experiment//Western Blot//Transfection//qPCR//FISH//Luciferase Report Assay//ELISA We found that circXPO1 was overexpressed in the lungs of CS-exposed mice and the CS extract (CSE)-treated alveolar epithelial cell line MLE12. Mechanistically, circXPO1 can directly bind to miR-23b-3p, preventing miR-23b-3p from binding to its target TGF-β-activated kinase 1/MAP3K7 binding protein 3 (TAB3)mRNA. In addition, under CSE conditions, miR-23b-3p overexpression recapitulated the prophylactic effects of circXPO1 knockdown. Yes Suppression of circXPO1 inhibited CSE-induced inflammatory cytokine production and cellular senescence. In vivo assays also demonstrated that circXPO1 knockdown attenuates CS-induced inflammation and senescence in the mouse lungs. 35907337 hsa_circ_0006872 LncRNA Homo sapiens Pulmonary Disease, Chronic Obstructive HPMECs and BEAS-2B cells Regulation(miR-145-5p/NF-κB axis) colony Formation Assay//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Cell Viability Assay//PCR//ELISA//Colony Formation Assay//IF Hsa_circ_0006872 level was elevated in COPD patients and was negatively correlated with miR-145-5p level. CSE exposure promoted apoptosis, inflammation and oxidative stress of HPMECs and BEAS-2B cells, while hsa_circ_0006872 down-regulation undermined the effects. In addition, hsa_circ_0006872 silencing inhibited CSE-induced cell injury via regulating miR-145-5p. Moreover, CSE contributed to the activation of NF-κB pathway through hsa_circ_0006872/miR-145-5p axis. Hsa_circ_0006872 facilitated CSE-triggered apoptosis, inflammation and oxidative stress in HPMECs and BEAS-2B cells by regulating miR-145-5p/NF-κB pathway. Yes In addition, hsa_circ_0006872 silencing inhibited CSE-induced cell injury via regulating miR-145-5p. Moreover, CSE contributed to the activation of NF-κB pathway through hsa_circ_0006872/miR-145-5p axis. 33248690 SNHG9 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer cell lines and tissues regulation[miR-214-5p/cryptochrome circadian regulator 2 axis] Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The results demonstrated that SNHG9 expression was remarkably lower in ovarian cancer cell lines and tissues compared with the negative controls. Thus, taken together, the current results suggest that SNHG9 may serve as a tumor suppressor gene in ovarian cancer by regulating the miR-214-5p/cryptochrome circadian regulator 2 axis. Yes Cell function assays demonstrated that decreased SNHG9 expression notably induced the migration, colony formation, proliferation and invasiveness of ovarian cancer cells. 33363617 SNHG9 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(SNHG9/miR-214-5p/SOX4 feedback loop) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay In this study, we found SNHG9 overexpression in OS tissues and cells. SNHG9 expression was positively regulated by the transcription factor SOX4. SNHG9 interacted with miR-214-5p as a molecular sponge and SOX4 was identified as the target of miR-214-5p. The interaction affected the expression of SNHG9, miR-214-5p, and SOX4, and regulated OS cell proliferation, migration, and invasion. Yes In addition, downregulated SNHG9 expression impaired the proliferation, migration, and invasion abilities of OS cells. 36004648 SNHG9 LncRNA Homo sapiens Glioma GSC-87 and GSC-251 cells Interaction(miR-326/SOX9 axis) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//EdU Staining SNHG9 expression was significantly higher in GSC-87 and GSC-251 cells than in U87 and U251 cells.Mechanistically, SNHG9 acted as a competitive endogenous RNA of miR-326 to elevate the expression of SOX9, a direct target of miR-326. Moreover, transfection with miR-326 inhibitor counteracted SNHG9 knockdown-mediated inhibition of GSC cell growth. Yes SNHG9 overexpression promoted GSC cell growth, whereas SNHG9 knockdown inhibited GSC cell growth. 33789359 SNHG9 LncRNA Homo sapiens Glioblastoma glioblastoma tissues Regulation[SNHG9/miR-199a-5p/Wnt2 Axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Results showed that the mRNA expression of SNHG9 was elevated in glioblastoma tissues. Overexpression of SNHG9 in glioblastoma cells promoted aerobic glycolysis and cell proliferation, which could be attenuated by miR-199a-5p. Results of this study indicated an effect of SNHG9/miR-199a-5p/Wnt2 axis in regulating cell growth and aerobic glycolysis in glioblastoma. The elevated SNHG9 expression was related to lower survival rate in patients with glioma. Yes Overexpression of SNHG9 in glioblastoma cells promoted aerobic glycolysis and cell proliferation, which could be attenuated by miR-199a-5p. Results of this study indicated an effect of SNHG9/miR-199a-5p/Wnt2 axis in regulating cell growth and aerobic glycolysis in glioblastoma. 31504670 SNHG9 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and serums Expression[lower expressed] qRT-PCR//MTT The results showed that LINC00346, LINC00578, and LINC00673 were highly expressed, whereas LINC00671, LINC00261, and SNHG9 were lowly expressed in PC tissues and serums, and their expression levels were correlated with clinical stages. Survival analysis indicated that patients with high expression of LINC00346, LINC00578, or LINC00673 had significantly lower survival rate, while patients with high expression of LINC00671, LINC00261, and SNHG14 had significantly higher survival rate. Yes In addition, we also found that silence of LINC00346, LINC00578 and LINC00673 inhibited PC cell proliferation, and silence of LINC00671, LINC00261, and SNHG14 promoted PC cell proliferation. 30210701 SNHG9 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and cells Expression [highly expressed] Western Blot//Transfection//CCK8//qRT-PCR//Colony Formation Assay SNHG9 expression levels were significantly upregulated in EC tissues and cells. Yes The knockdown of SNHG9 subsequently effectively attenuated cell proliferation and glycolysis in vitro, while SNHG9 overexpression reported the opposite effects. 33821518 hsa_circ_0040929 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive serum of COPD patients Interaction(miR-515-5p/IGFBP3 axis) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//ELISA Circ_0040929 expression and IGFBP3 expression were upregulated in the serum of smokers (n = 22) compared to non-smokers (n = 22) and more significantly upregulated in the serum of COPD patients (n = 22). However, miR-515-5p expression was decreased in the serum of smokers compared to non-smokers and further reduced in the serum of COPD. MiR-515-5p was a direct target of circ_0040929, and miR-515-5p inhibition reversed the effect of circ_0040929 knockdown in CSE-treated 16HBE cells. IGFBP3 was a direct target of miR-515-5p, and miR-515-5p overexpression alleviated CSE-induced cell injury via targeting IGFBP3. Moreover, circ_0040929 regulated IGFBP3 expression by targeting miR-515-5p. Importantly, circ_0040929 was upregulated in serum exosomes from COPD patients. Yes Circ_0040929 knockdown attenuated CSE-induced cell injury by increasing proliferation and reducing apoptosis, inflammation, and airway remodeling in 16HBE cells. 36101791 SNHG9 LncRNA Homo sapiens Hepatoblastoma hepatoblastoma tissue and cell lines (miR-23a-5p/Wnt3a Axis) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis SNHG9 was significantly upregulated in hepatoblastoma tissue and cell lines. Dual luciferase activity, RNA immunoprecipitation and biotin pull down confirmed the direct interaction of miR-23a-5p with SNHG9. ROC and Kaplan-Meier analysis showed potential prognostic and diagnostic importance of SNHG9 in hepatoblastoma. Yes SNHG9 overexpression on HUH6 & HepG2 resulted in a significant increase in cell proliferation and clonogenic activity while SNHG9 knock down resulted in a sustained inhibition of cell proliferation and clonogenic activity.Dual luciferase activity, RNA immunoprecipitation and biotin pull down confirmed the direct interaction of miR-23a-5p with SNHG9. The xenograft tumorgenicity test showed SNHG9 downregulation significantly inhibited the tumor growth in BALB/c mice. 34539877 SNHG9 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation(GSTP1) ChIP//CCK8//qRT-PCR//FISH//RIP//migration assay//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//Transwell Assay There was an upregulated expression of SNHG9 in HCC, which was associated with shorter disease-free survival. LncRNA SNHG9 recruits methylated enzymes (DNMT1, DNMT3A, and DNMT3B) to increase GSTP1 promoter methylation, a common event in the development of HCC. There was an upregulated expression of SNHG9 in HCC, which was associated with shorter disease-free survival. Yes Knockdown of SNHG9 can inhibit cell proliferation, block cell cycle progression, and inhibit cell migration and invasion by upregulating GSTP1. 33898523 SNHG8 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissue Regulation[miR-491/PDGFRA axis] CCK8//qRT-PCR//Transwell Assay//Western Blot This study illustrated that SNHG8 expression was upregulated in GC tissues, as well as in cell lines. LncRNA SNHG8 promoted the proliferation and invasion of GC cells by targeting the miR-491/PDGFRA axis, which might provide new insight for potential therapeutic strategies for GC in the future. Yes Moreover, knockdown of SNHG8 inhibited GC cell proliferation and invasion. Significantly, we determined that miRNA-491 was not only downregulated in stomach cancer but also inhibited GC cell progression induced by SNHG8. 31620977 SNHG8 LncRNA Homo sapiens Breast Neoplasms tumor tissues and cell lines regulation[miR-634/ZBTB20 axis] CCK8//qRT-PCR//Flow Cytometry//EdU Staining//Transwell Assay qRT-PCR results showed that the expression level of SNHG8 was significantly upregulated in tumor tissues and cell lines. The SNHG8-miR-634-ZBTB20 pathway may be a potential target for the treatment of breast cancers. Yes Gene functional studies showed that the downregulation of the expression level of SNHG8 significantly inhibited the breast cancer cells migration and invasion, and induced apoptosis. 33275231 circScd1 CircRNA Homo sapiens Non-alcoholic Fatty Liver Disease NAFLD tissues Interaction[Janus Kinase 2/Signal ] qRT-PCR//Western Blot CircScd1 expression was significantly lower in NAFLD tissues than in control tissues. Western blot analyses showed that the protein levels of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) were significantly increased. However, knockdown of circScd1 significantly promoted the degree of hepatocellular lipidosis and reduced the expression levels of JAK2 and STAT5. Yes However, knockdown of circScd1 significantly promoted the degree of hepatocellular lipidosis and reduced the expression levels of JAK2 and STAT5. 30259280 SNHG8 LncRNA Homo sapiens Breast Neoplasms breast cancer cells Interaction(miR-634/ZBTB20 Axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay We found that proliferation, migration, and invasion of breast cancer cells were significantly inhibited due to knockdown of lncRNA SNHG8, while inducing apoptosis of these cells. Mechanistically, SNHG8 functioned as an inhibitor of miR-634 in tumor tissues . LncRNA SNHG8 sponged the miR-634 to increase the expression level of ZBTB20, thus further aggravating the malignancy of breast cancer. Yes We found that proliferation, migration, and invasion of breast cancer cells were significantly inhibited due to knockdown of lncRNA SNHG8, while inducing apoptosis of these cells. 33854372 SNHG8 LncRNA Homo sapiens Colorectal Neoplasms primary tumor tissues Interaction( miR-588/ATG7 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//IF The results of the present study demonstrated that SNHG8 expression was substantially upregulated in primary tumor tissues from The Cancer Genome Atlas dataset. Notably, the function of SNHG8 in enhancing autophagy was dependent on autophagy-related gene 7 (ATG7). In addition, western blot analysis indicated that the effect of SNHG8 on autophagy in CRC cells was dependent on the miR-588/ATG7 axis. Yes Western blot and immunofluorescence analyses demonstrated that SNHG8 facilitated cell proliferation and autophagy in CRC cells. 34122628 SNHG8 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines interaction[miR-149-5p] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression levels of lncRNA SNHG8 were dramatically increased in HCC tissues and cell lines as compared with the adjacent normal tissues, and SNHG8 expression was an independent prognostic factor of tumor recurrence in HCC patients.As lncRNA SNHG8 may promote HCC tumorigenesis and metastasis by sponging miR-149, it is a potential candidate marker and therapeutic target for HCC. Yes Furthermore, knockdown of SNHG8 inhibited cell proliferation, invasion, and lung metastasis in vitro and in vivo, whereas overexpression of SNHG8 reversed these effects. 30537734 circBPTF CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive Interaction(miR-486-5p/CEMIP ) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Microarray//Cell Proliferation Assay circRNA microarray and real-time PCR analyses show significantly higher level of circ-BPTF and lower miR-486-5p level in the pulmonary arteries of COPD patients as compared with controls. Moreover, luciferase reporter assay results indicate that circ-BPTF regulates PASMC proliferation by acting as an miR-486-5p sponge. CEMIP is identified as a candidate target gene of miR-486-5p by luciferase reporter assay. Yes Hypoxia suppresses miR-486-5p expression but promotes expressions of circ-BPTF and cell migration inducing protein (CEMIP) in human pulmonary arterial smooth muscle cells (PASMCs) in vitro. Loss- and gain-of-function experiments show that circ-BPTF promotes PASMC proliferation in vitro. 36514216 circCCAC1 CircRNA Homo sapiens Adrenocortical Carcinoma ACC tissue specimens and cell lines regulation[miR-514a-5p/C22orf46 Axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay As a result, circ-CCAC1 was overexpressed in ACC tissue samples and cell lines and correlated with poor prognosis.A rescue assay illustrated that circ-CCAC1 facilitated ACC progression through miR-514a-5p/C22orf46 signaling. As a result, circ-CCAC1 was overexpressed in ACC tissue samples and cell lines and correlated with poor prognosis. Yes Gain- and loss-of-function tests demonstrated that circ-CCAC1 acted as an oncogene in ACC. 33195693 SNRPFP1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-126-5p) qRT-PCR On basis of our previous research and the constructed online database for the non-coding RNAs related to HCC, a series of pseudogene transcripts have been discovered, and SNRPFP1, the homologous pseudogene of SNRPF, was found to produce an anomalously high expression long non-coding RNA in HCC. Interestingly, miR-126-5p, one of the tumor-suppressive genes commonly decreased in HCC, was found negatively expressed and correlated with SNRPF1, and a specific region of SNRPF1 transcript is directly binding to miR-126-5p in a molecular sponge way. Yes And depletion of SNRPF1 in HCC cells significantly suppressed cell proliferation and apoptosis resistance. 36535956 circSEC24A CircRNA Homo sapiens Skin Neoplasms CSCC tissues and cells Interaction(miR-1193/MAP3K9 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Bioinformatics Analysis//Transwell Assay CircSEC24A and MAP3K9 were upregulated and miR-1193 was downregulated in CSCC tissues and cells. Moreover, miR-1193 was a direct target of circSEC24A and its downregulation reversed the inhibitory effect of circSEC24A knockdown on the progression of CSCC cells. Furthermore, MAP3K9 was a downstream target of miR-1193 and its upregulation attenuated the anti-cancer role of miR-1193 in CSCC cells. Yes CircSEC24A knockdown inhibited the progression of CSCC cells by inhibiting cell proliferation, migration, invasion, and glycolysis and inducing apoptosis. 33519212 circUBAP2 CircRNA Homo sapiens Pre-Eclampsia placental tissues Expression(lower expressed) Western Blot//Transfection//qPCR//migration assay//Cell Apoptosis Assay//Luciferase Report Assay//Colony Formation Assay Preeclampsia Yes After knocking down circUBAP2 in trophoblast cells, we found that cell proliferation and migration were significantly suppressed. In addition, preliminary mechanistic studies showed that circUBAP2 can sponge miR-1244, and FOXM1 was identified as a target gene for miR-1244. 33502747 circZDHHC20 CircRNA Homo sapiens Pre-Eclampsia PE placenta regulation[miR-144/GRHL2 axis] Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Our data indicated that circZDHHC20 was up-regulated and miR-144 was down-regulated in PE placenta. Our study suggested that a high level of circZDHHC20 inhibited the proliferation, migration, and invasion in trophoblast cells at least partially through sponging miR-144 and up-regulating GRHL2, providing a novel mechanism of PE pathogenesis. Yes CircZDHHC20 overexpression repressed trophoblast cell proliferation, migration, and invasion, while its knockdown exerted opposite effects. 31956297 circPAPPA CircRNA Homo sapiens Pre-Eclampsia placenta ,blood Interaction[miR-384/STAT3 pathway] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//cell invasion assay In the present study, we found the expression of a circRNA, hsa_circ_0088227 (circRNA of pregnancy-associated plasma protein A, circPAPPA), was down-regulated in both placenta and plasma samples from subjects with PE.miR-384 was identified as a direct target of circPAPPA, and the gene encoding signal transducer and activator of transcription 3 (STAT3) was targeted by miR-384. We found that miR-384 was unregulated in PE, and overexpression of miR-384 could inhibit cell proliferation and invasion. In addition, we showed that the expression of STAT3 was decreased with knockdown of circPAPPA or the overexpression of miR-384 in trophoblast cells, but this decrease was partially reversed when co-transfection was performed with mimics of miR-384 inhibitor and si-circPAPPA. Together, these results suggest that down-regulation of circPAPPA facilitates the onset and development of PE by suppressing trophoblast cells, with involvement of the miR-384/STAT3 signaling pathway. Our study significantly increases the understanding of the occurrence and development of PE, and also provides a molecular target for the treatment of this disorder. Yes Knockdown of circPAPPA led to decreased proliferation and invasion in HTR8-S/Vneo trophoblast cells. 31427481 hsa_circ_0001821 CircRNA Homo sapiens Skin Neoplasms CSCC tissues and cells Interaction(MicroRNA-148a-3p/EGFR Axis ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay circ_0001821 level was increased in CSCC tissues and cells.For mechanism analysis, circ_0001821 directly targeted miR-148a-3p to elevate EGFR expression. Downregulation of miR-148a-3p weakened the impacts of circ_0001821 deficiency on CSCC malignant phenotypes. Moreover, miR-148a-3p overexpression inhibited the malignant phenotypes of CSCC cells, with EGFR elevation abrogating the effects. In addition, circ_0001821 knockdown blocked the activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Yes circ_0001821 knockdown restrained cell viability, colony formation, cell cycle processes, and metastasis, and facilitated cell apoptosis in vitro, and restrained tumor growth in vivo. 35191745 circLARP1B CircRNA Homo sapiens Skin Neoplasms CSCC tissues and cell lines Interaction(microRNA-515-5p/TPX2 ) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Circ-LARP1B expression was up-regulated in CSCC tissues and cell lines. miR-515-5p was a direct target of circ-LARP1B in CSCC cells, and circ-LARP1B silencing-mediated anti-tumor effects were largely counteracted by miR-515-5p knockdown. miR-515-5p directly interacted with the 3' untranslated region (3'UTR) of TPX2. TPX2 overexpression largely overturned miR-515-5p-mediated anti-tumor effects in CSCC cells. Circ-LARP1B could up-regulate TPX2 expression by sponging miR-515-5p in CSCC cells. Circ-LARP1B knockdown suppressed tumor growth in vivo. In conclusion, circ-LARP1B contributed to CSCC progression by targeting miR-515-5p/TPX2 axis. The circ-LARP1B/miR-515-5p/TPX2 axis might provide novel therapeutic targets for CSCC patients. Yes Circ-LARP1B knockdown suppressed cell viability, colony formation ability, migration, invasion, cell cycle progression, and glycolysis and triggered cell apoptosis in CSCC cells. 34982022 circEBF1 CircRNA Homo sapiens Skin Neoplasms CSCC tissues and cells Interaction(miR-1247-5p/CSF3 axis) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//RIP//Colony Formation Assay//EdU Staining circEBF1 and CSF3 were up-regulated, while miR-1247-5p was down-regulated in CSCC tissues and cells. In addition, circEBF1 sponged miR-1247-5p to regulate CSCC cell development. Also, miR-1247-5p suppressed CSCC cell progression by inhibiting CSF3. Yes Interference of circEBF1 hindered the proliferation, migration, invasion, and glycolysis of CSCC cells and promoted apoptosis. Moreover, depletion of circEBF1 blocked CSCC tumor growth in vivo. 35543246 hsa_circ_0008234 CircRNA Homo sapiens Skin Neoplasms cSCC tissues & cSCC cells Interaction(miR-127-5p-ADCY7 ) Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay hsa_circ_0008234 was confirmed to be highly expressed in cSCC tissues by qRT-PCR. Hsa_circ_0008234 was mainly located in cytoplasm and stable in cSCC cells. RIP experiment revealed that hsa_circ_0008234 directly interacts with miR-127-5p in cSCC cells. Hsa_circ_0008234 increased the cell viability and colony formation of cSCC cells through acting as the sponge of miR-127-5p. MiR-127-5p inhibited the expression of ADCY7 in cSCC cells through binding the 3'UTR of ADCY7. Hsa_circ_0008234 was positively associated with ADCY7 expression in cSCC tissues. Hsa_circ_0008234 facilitates the proliferation of cSCC through targeting miR-127-5p to regulate ADCY7 expression Yes RIP experiment revealed that hsa_circ_0008234 directly interacts with miR-127-5p in cSCC cells 34143288 circCYP24A1 CircRNA Homo sapiens Skin Neoplasms exosomal Expression(highly expressed) qRT-PCR//Transfection//RNA-seq//Transwell Assay Among them, circulating circ-CYP24A1 was confirmed to be up-regulated in cSCC. Yes After incubation with si-circ-CYP24A1-transfected exosomes, proliferation, migration, and invasion were lowered while apoptosis was enhanced in A431 and SCL-1 cells. Meanwhile, si-circ-CYP24A1-transfected exosomes significantly decreased the expression of downstream targets CDS2, MAVS, and SOGA in cSCC cells. 34109199 hsa_circ_0067772 CircRNA Homo sapiens Skin Neoplasms CSCC tissues and cells Interaction(miR-1238-3p/FOXG1 axis ) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Circ_0067772 and FOXG1 were upregulated, while miR-1238-3p was downregulated in CSCC tissues and cells. MiR-1238-3p served as a target of circ_0067772, whose silencing could reverse circ_0067772 knockdown-induced inhibitory impact on the malignant cellular behaviors. Circ_0067772 positively regulated FOXG1 expression by antagonizing miR-1238-3p. Additionally, miR-1238-3p could repress CSCC cell proliferation, migration and invasion by targeting FOXG1. Yes Circ_0067772 knockdown conferred inhibitory effects on cell proliferation, migration and invasion of CSCC cells. circ_0067772 knockdown hindered CSCC tumor growth in vivo. 33709381 circLDLR CircRNA Homo sapiens Non-alcoholic Fatty Liver Disease Hepa1-6 cells Interaction(miR-667-5p/SIRT1 axis) In Vivo Experiment//Western Blot//Transfection//FISH//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis The circLDLR expression showed a prominent down-regulation in OA/PA-treated Hepa1-6 cells, whereas the LDLR expression was up-regulated. CircLDLR and SIRT1 are common targets of miR-667-5p to inhibit the TG and TC and promote the autophagy pathway. SIRT1 knockdown reversed the effects of circLDLR overexpression. Yes Overexpression of circLDLR significantly attenuated lipid droplet accumulation in NAFLD models in vitro/vivo, reduced TG, TC, and p62 levels, and increased LC3-II levels and the amount of the green fluorescent protein (GFP)-LC3 puncta in cells. 36443854 circFADS2 CircRNA Homo sapiens Skin Neoplasms CSCC tissues and cells Interaction( miR-766-3p/HOXA9 axis ) In Vivo Experiment//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Colony Formation Assay//Transwell Assay CircFADS2 was downregulated in CSCC tissues and cells. Moreover, miR-766-3p was able to directly bind to circFADS2, and circFADS2 played an anti-cancer role in CSCC by downregulating miR-766-3p. In addition, HOXA9 was a direct target of miR-766-3p, and miR-766-3p inhibition suppressed CSCC cell proliferation, metastasis and glycolysis by upregulating HOXA9. Furthermore, circFADS2 acted as a sponge of miR-766-3p to regulate HOXA9 expression. Yes CircFADS2 overexpression inhibited CSCC cell proliferation, metastasis and glycolysis. Besides, circFADS2 suppressed tumor growth in vivo. 34913472 hsa_circ_0070934 CircRNA Homo sapiens Skin Neoplasms cell lines regulation[circ-0070934/miR-1236-3p/HOXB7 regulatory axis ] CCK8//qRT-PCR//Luciferase Report Assay//Flow Cytometry The results demonstrated that the expression of circ?0070934 was stably upregulated in a number of CSCC cell lines compared with that in normal human keratinocytes.In conclusion, the results of the present study demonstrated the effects of the circ‑0070934/miR‑1236‑3p/HOXB7 regulatory axis on CSCC and provided a novel insight for the pathogenesis of CSCC. Yes Knockdown of circ?0070934 inhibited the invasive and proliferative potential of CSCC cells and promoted apoptosis both in vivo and in vitro. 32626939 hsa_circ_001937 CircRNA Homo sapiens Skin Neoplasms CSCC tissues and cell lines regulation[miRNA-597-3p/FOSL2 pathway] qRT-PCR//Western Blot circRNA_001937 expression levels were significantly increased in CSCC tissues and cell lines compared with the corresponding adjacent tissues and control cells (P<0.05). In conclusion, circRNA_001937 expression was increased in CSCC and silencing circRNA_001937 gene expression may inhibit CSCC progression by sponging the miRNA‑597‑3p/FOSL2 pathway. Yes The genetic silencing of circRNA_001937 with small interfering RNA significantly inhibited cell proliferation, and induced cell apoptosis (P<0.05). 33000177 hsa_circ_0040414 CircRNA Homo sapiens Heart Failure peripheral blood of patients with chronic heart failure (CHF) Interaction(miR-186-5p/PTEN) Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//ELISA Consistent with previous studies, our study showed that the expression of circ_0040414 in the peripheral blood of patients with chronic heart failure (CHF) was significantly higher than that of healthy control, which indicated that circ_0040414 could be used as a diagnostic biomarker in patients with CHF.In terms of mechanism, circ_0040414 upregulated the expression of phosphatase and tensin homolog (PTEN) through sponging miR-186-5p to inhibit AKT signaling activity. Consistent with previous studies, our study showed that the expression of circ_0040414 in the peripheral blood of patients with chronic heart failure (CHF) was significantly higher than that of healthy control, which indicated that circ_0040414 could be used as a diagnostic biomarker in patients with CHF. Yes In cardiomyocytes, circ_0040414 increased the level of proapoptotic proteins Bax, cleaved-caspase 3 and reduced the expression of antiapoptotic protein Bcl-2. It also promoted inflammatory factors IL-6, TNF-α, and IL-β, but inhibited cell proliferation. 34369049 circVAPA CircRNA Homo sapiens Mouth Neoplasms oral cancer tissues and cells Interaction( miR-132/HOXA7 axis) Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay circVAPA expression was significantly increased in oral cancer tissues and cells. MiR-132 was identified as a target of circVAPA in Cal-27 cells. Cotransfection with si-circVAPA and miR-132 inhibitor reversed the inhibitory effect of circVAPA knockdown on cell malignant phenotypes. HOXA7 was further identified as a downstream target of miR-132. The overall survival and progression-free survival of patients with oral cancer who exhibited high circVAPA expression were significantly shorter compared with those with low expression. circVAPA expression was closely related to tumor size, TNM stage and distant metastasis. Yes circVAPA knockdown reduced the proliferation, invasion and migration of Cal-27 cells. 34102907 hsa_circ_102450 CircRNA Homo sapiens Mouth Neoplasms OSCC cells and preoperative liquid biopsy samples Interaction(miR-1178) cell invasion assay//qRT-PCR//Luciferase Report Assay//migration assay//Microarray//Cell Proliferation Assay CircRNA microarray showed that circRNA-102450 was down-regulated in OSCC cells. Clinical validation of circRNA-102450 was performed using highly sensitive droplet digital PCR in preoperative liquid biopsy samples from 30 OSCC patients. Interestingly, none of 16 studied patients with high circRNA-102450 had regional lymph node metastasis (RLNM), whereas 4 of 14 studied patients (28.5%) with low expression had pathologically proven RLNM. Yes Overexpressed circRNA-102450 significantly inhibited the tumor metastatic properties of cell proliferation, migration, and invasion. Furthermore, circRNA-102450 directly bound to, and consequently down-regulated, miR-1178 in OSCC cells. 34830863 circHECTD1 CircRNA Homo sapiens Cerebral Infarction OGD/R-treated HT22 cells Interaction(miR-27a-3p/FSTL1 axis) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//EdU Staining Circ_HECTD1 and FSTL1 were highly expressed, and miR-27a-3p was decreased in OGD/R-treated HT22 cells. Mechanical analysis discovered that circ_HECTD1 could regulate FSTL1 expression by sponging miR-27a-3p. Yes Moreover, circ_HECTD1 knockdown could boost cell proliferative ability and repress apoptosis in OGD/R-triggered HT22 cells in vitro. 33843447 circHIPK3 CircRNA Homo sapiens Arthritis, Gouty SFMCs Interaction(miR-561 and miR-192) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//Luciferase Report Assay//ELISA circHIPK3 was elevated in synovial fluid mononuclear cells (SFMCs) from patients with gouty arthritis and monosodium urate (MSU)-stimulated THP-1 cells. circHIPK3 overexpression promoted the inflammatory cytokines levels in MSU-stimulated THP-1 cells, and circHIPK3 silencing obtained the opposite effect. Mechanistically, circHIPK3 sponged miR-192 and miR-561, and subsequently promoted the expressions of miR-192 and miR-561 target gene TLR4 and NLRP3. In vivo experiments confirmed circHIPK3 knockdown suppressed gouty arthritis. circHIPK3 sponges miR-192 and miR-561 to promote TLR4 and NLRP3 expressions, thereby promoting inflammatory response in gouty arthritis. Yes circHIPK3 overexpression promoted the inflammatory cytokines levels in MSU-stimulated THP-1 cells, and circHIPK3 silencing obtained the opposite effect. In vivo experiments confirmed circHIPK3 knockdown suppressed gouty arthritis. circHIPK3 sponges miR-192 and miR-561 to promote TLR4 and NLRP3 expressions, thereby promoting inflammatory response in gouty arthritis. 34085163 SOX2-OT LncRNA Homo sapiens Uterine Cervical Neoplasms C-33A (HPV) and SiHa (HPV16) cells regulation[ regulating SOX2] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Interestingly, both high-expression levels of SOX2OT transcript 7 (SOX2OT-7) and SOX2 were detected in C-33A (HPV) and SiHa (HPV16) cells. In conclusion, these findings indicate that lncRNA SOX2OT contributes to the growth, migration and invasion of cervical cancer cells by modulating SOX2. Yes Thus, C-33A and SiHa cells were conducted to investigate the effects of SOX2OT on cell growth, migration and invasion. 32286144 SOX2-OT LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer cell regulation[SOX2] Western Blot//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay SOX2OT was highly expressed in bladder cancer, and increased SOX2OT expression was positively correlated with a high histological grade, advanced TNM stage and poor prognosis. This study is the first to demonstrate that SOX2OT plays an important regulatory role in BCSCs and that SOX2OT may serve as a potential diagnostic biomarker and therapeutic target in bladder cancer. SOX2OT was highly expressed in bladder cancer, and increased SOX2OT expression was positively correlated with a high histological grade, advanced TNM stage and poor prognosis. Yes Further experiments demonstrated that knockdown of SOX2OT inhibited the stemness phenotype of BCSCs. Moreover, inhibition of SOX2OT delayed xenograft tumour growth and decreased metastases in vivo. 32019566 SNHG8 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines regulation[microRNA-876-5p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, we found that SNHG8 levels were obviously upregulated in OS tissues and cell lines.In conclusion, our study suggested that SNHG8 stimulates cell growth and migration of OS cells by functioning as a ceRNA of miR-876-5p, indicating SNHG8 may be served as a novel prognostic biomarker and therapeutic target for the treatment of OS. High expression of SNHG8 was significantly correlated with increased tumor size and advanced Enneking stage, and predicted a poor prognosis of OS patients. Yes Functional assays revealed that SNHG8 knockdown inhibited OS cell growth and migration in vitro, and restrained tumor growth of OS in nude mice in vivo. 32774713 ST8SIA6-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Interaction(miR-145-5p/CDCA3) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay ST8SIA6-AS1 displayed a higher expression in TNBC cells. Mechanistically, ST8SIA6-AS1 could facilitate the expression of its target CDCA3 (cell division cycle associated protein 3) and inactivate the p53/p21 signaling by inhibiting miR-145-5p. Moreover, miR-145-5p exerted a tumor-suppressive activity by targeting CDCA3. The tumor-suppressive effects induced by ST8SIA6-AS1 knockdown were abated by the down-regulation of miR-145-5p or the up-regulation of CDCA3. Yes Silencing ST8SIA6-AS1 impaired cell proliferation, cell cycle progression, migration, and invasion in vitro, and slowed tumor growth in vivo. 35730485 STARD13-AS LncRNA Homo sapiens lung squamous cell carcinoma LUSC samples regulation[miR-1248/C3A] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay By consulting the TCGA database and GEPIA website, we found that C3A expression was significantly reduced in LUSC samples.Our findings revealed that overexpression of STARD13-AS restricted the growth and aggressiveness of LUSC cells via regulating miR-1248/C3A. Yes Moreover, STARD13-AS was under expressed in LUSC cells and has a negative effect on LUSC cells growth ability. 32949706 ST8SIA6-AS1 LncRNA Homo sapiens Breast Neoplasms BC tumour tissues regulation[p38 MAPK signalling pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay We found that the expression of ST8SIA6-AS1 was elevated in BC tumour tissues compared with the adjacent normal tissues in the samples from the TCGA and GEO datasets, as well as in 138 BC tissue samples obtained by us. Rescue experiments indicated that ST8SIA6-AS1 promoted BC cell proliferation, invasion and migration in a p38 MAPK signalling-mediated manner. The high expression of ST8SIA6-AS1 was associated with estrogen receptor-negative, progesterone receptor-negative, advanced tumour-node-metastasis stage and worse survival in BC patients. Yes In vitro functional studies revealed that high expression of ST8SIA6-AS1 promoted proliferation, invasion and migration of BC cell lines. The results of the in vivo studies indicated that upregulation of ST8SIA6-AS1 promoted xenograft tumour growth of BC. 31784750 ST8SIA6-AS1 LncRNA Homo sapiens Breast Neoplasms  breast cancer tissues  Expression [highly expressed] CCK8//qRT-PCR Seven lncRNAs, comprising ST8SIA6-AS1, lnc-HIST1H2BJ-5:1, lnc-PRICKLE2-3:2, RP1-86C11.7, RP11-15F12.1, ZNF670-ZNF695 and lnc-STRN3-12:1, were shown to be significantly up-regulated in breast cancer. lncRNA ST8SIA6-AS1 was associated with TNM staging and Ki-67 index. Yes The cell function assays showed that ST8SIA6-AS1 can promote the proliferation, migration and invasion of breast cancer cells. The functions of ST8SIA6-AS1 were explored and the competing endogenous RNA mode showed that miR-4252 was a potential candidate. 33037712 ST8SIA6-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[miR-5195/PCBP2 axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay This study revealed that lncRNA ST8SIA6-AS1 was upregulated in CRC tissues and cells.Our study revealed that ST8SIA6-AS1 promoted CRC progression via the miR-5195/PCBP2 axis. Yes Knockdown of ST8SIA6-AS1 inhibited proliferation, migration, and invasion of CRC cells. 32373956 ST8SIA6-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-338/MEPCE axis] Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The results revealed that the expression levels of ST8SIA6?AS1 were upregulated in HCC tissues and cell lines, which were associated with a poor prognosis.In conclusion, the findings of the present study suggest that lncRNA ST8SIA6‑AS1 may promote the migration and invasion of hypoxia‑induced HCC cells via the miR‑338/MEPCE axis, indicating a potential diagnostic or therapeutic marker for HCC treatment. The results revealed that the expression levels of ST8SIA6?AS1 were upregulated in HCC tissues and cell lines, which were associated with a poor prognosis. Yes Moreover, the genetic knockdown of ST8SIA6?AS1 inhibited the hypoxia?induced HCC cell migration and invasion. 33416148 ST8SIA6-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[MAGEA3 and DCAF4L2] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Moreover, ST8SIA6-AS1 was highly expressed in HCC in-house tissues and cells, and ST8SIA6-AS1 upregulation was related to aggressive tumor phenotypes and the poor overall survival of HCC patients.ST8SIA6-AS1 partly directly bound to miR-129-5p and functioned as a competing endogenous RNA (ceRNA), subsequently facilitating the expression of the miR-129-5p target gene DCAF4L2 to play its role in HCC. Moreover, ST8SIA6-AS1 was highly expressed in HCC in-house tissues and cells, and ST8SIA6-AS1 upregulation was related to aggressive tumor phenotypes and the poor overall survival of HCC patients. Yes Downregulation of ST8SIA6-AS1 suppressed HCC cell proliferation, migration and invasion in vitro and restrained HCC tumorigenesis in vivo. 33012505 ST8SIA6-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[miR-4656/HDAC11 axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot In this study we demonstrated that ST8SIA6-AS1 was an upregulated lncRNA in hepatocellular carcinoma. In conclusion, our findings suggested that ST8SIA6-AS1 was a novel upregulated lncRNA in HCC and could facilitate cell proliferation and resistance to cell apoptosis via sponging miR-4656 and elevation of HDAC11, which might be a promising biomarker for patients with HCC. Yes SiRNA-mediated knockdown of ST8SIA6-AS1 repressed cell proliferation and induced cell apoptosis in HCC cells. 32536820 ST8SIA6-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-651-5p/TM4SF4 axis) qRT-PCR Highly expressed ST8SIA6-AS1 and TM4SF4 as well as poorly expressed miR-651-5p were detected in HCC tissues and cells. Clinically, miR-651-5p expression in HCC tissues is negatively correlated with ST8SIA6-AS1 or TM4SF4. ST8SIA6-AS1 exhibited its oncogenic function by sponging tumor suppressor miR-651-5p, and the anti-oncogenic of miR-651-5p was offset by its TM4SF4. The manipulation of ST8SIA6-AS1/miR-651-5p/TM4SF4 axis-mediated oncogenicity in HCC might shed new light on HCC diagnosis and therapy. Yes Cell functional assays demonstrated that ST8SIA6-AS1 silencing resulted in weakened proliferative and migratory capacities in HCC cells in addition to increase Bax expression and reduced Bcl-2 expression. 35946523 ST8SIA6-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cell lines, tissues, and plasma regulation[ST8SIA6-AS1/miR-125a-3p/NNMT] RNA Pull-Down//ChIP//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay Herein, we found that ST8SIA6-AS1 was frequently overexpressed in LUAD cell lines, tissues, and plasma.Collectively, our data demonstrate that ST8SIA6-AS1 is a carcinogenic lncRNA in LUAD, and targeting the axis of ST8SIA6-AS1/miR-125a-3p/NNMT may be a promising treatment for LUAD patients. Yes Depletion of ST8SIA6-AS1 significantly inhibited LUAD cell proliferation and invasion in vitro and tumor growth in vivo. 33363573 STCAT16 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] CCK8//qRT-PCR//Wound Healing Assay//Colony Formation Assay The present data suggested that the expression level of STCAT16 was decreased in GC tissues. The expression level of STCAT16 was identified to be associated with lymph node and tumour node metastasis stages. Furthermore, the expression level of STCAT16 was identified to be significantly associated with poor survival and prognosis. Yes . Knockdown of STCAT16 promoted proliferation, colony formation, migration and invasion of BGC‑823 cells. In contrast, these features were suppressed in AGS cells following overexpression of STCAT16. In vivo, tumour growth was significantly decreased following STCAT16 overexpression. 30957180 ST8SIA6-AS1 LncRNA Homo sapiens Cholangiocarcinoma CHOL tissues and cell lines Interaction(miR-145-5p/MAL2 Axis) CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU//Bioinformatics Analysis//Transwell Assay Findings revealed the enrichment of ST8SIA6-AS1 in CHOL tissues and cell lines. The results of experiments showed that ST8SIA6-AS1 sponged miR-145-5p, thereby allowing MAL2 to exert its biological function on CHOL cells. Yes It was also found that ST8SIA6-AS1 facilitated cell growth and migration, but it reduced the apoptosis level of the CHOL cells. 34040387 ST8SIA6-AS1 LncRNA Homo sapiens Liver Neoplasms liver cancer tissues and cell lines Interaction( miR-142-3p) RNA Pull-Down//Transfection//Migration Assay//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay The results indicated that ST8SIA6-AS1 was highly expressed in liver cancer tissues and cell lines, and the high expression of ST8SIA6-AS1 in liver cancer tissues was associated with poor prognosis. Mechanistic investigation revealed that ST8SIA6-AS1 sequesters miR-142-3p and negatively regulates miR-142-3p expression in liver cancer cells. Further investigation indicated that the tumor-inhibitory effect of ST8SIA6-AS1 silencing was reversed by miR-142-3p depletion. The results indicated that ST8SIA6-AS1 was highly expressed in liver cancer tissues and cell lines, and the high expression of ST8SIA6-AS1 in liver cancer tissues was associated with poor prognosis. Yes Knockdown of ST8SIA6-AS1 inhibited the proliferation, metastasis and invasion of liver cancer cells. 34659494 ST7-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary THCA tumors and PTC cell lines Interaction(miR-181b-5p/TRIM3 axis) CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay In this study, ST7-AS1 was mainly distributed in the cytoplasm of PTC cells and presented reduced expression in THCA tumors and PTC cell lines. The expression of miR-181b-5p was upregulated and it bound with ST7-AS1 in PTC cells. Moreover, TRIM3 exhibited downregulated expression level in PTC cells and ST7-AS1 elevated TRIM3 expression via harboring miR-181b-5p. Rescue experiments illuminated that knockdown of TRIM3 reversed ST7-AS1 overexpression-induced promotion on PTC cell proliferation and suppression on PTC cell apoptosis. Yes Functional experiments revealed that overexpressed ST7-AS1 inhibited the viability and proliferation of PTC cells, whereas accelerated the apoptosis of PTC cells. 36030355 ST7-AS1 LncRNA Homo sapiens Glioma glioma tissues Interaction(p53/ST7-AS1/PTBP1 axis) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//ISH//Transfection//qPCR//CCK8//FISH//RIP//IF//Luciferase Report Assay//H&E Staining//IHC//EdU Staining//Transwell Assay ST7-AS1 expression was reduced in glioma tissues and cells in comparison to normal brain tissues. p53 transcriptionally targeted the ST7-AS1 promoter in U251 glioma cells. The targeting significantly inhibited cell migration, invasion, and proliferation, and promoted apoptosis. ST7-AS1 directly bound to and downregulated polypyrimidine tract-binding protein 1 (PTBP1) at the post-transcriptional level. ST7-AS1 overexpression inhibited glioma progression by suppressing Wnt/β-catenin signalling by downregulating PTBP1 expression. Yes p53 transcriptionally targeted the ST7-AS1 promoter in U251 glioma cells. The targeting significantly inhibited cell migration, invasion, and proliferation, and promoted apoptosis. ST7-AS1 directly bound to and downregulated polypyrimidine tract-binding protein 1 (PTBP1) at the post-transcriptional level. ST7-AS1 overexpression inhibited glioma progression by suppressing Wnt/β-catenin signalling by downregulating PTBP1 expression. 33476649 ST7-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues or cell lines regulation[miR-181b-5p/KPNA4 axis] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay ST7-AS1 was upregulated in LUAD tissues or cell lines, correlated with tumours of positive lymph node metastasis or higher TNM stages, and associated with shorter overall survival of LUAD patients. ST7-AS1 was upregulated in LUAD tissues or cell lines, correlated with tumours of positive lymph node metastasis or higher TNM stages, and associated with shorter overall survival of LUAD patients. Yes In vivo, targeting ST7-AS1 significantly inhibited xenograft growth and metastasis. 33327962 ST7-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Interaction[CARM1 ] FISH//Luciferase Report Assay//Migration Assay We found that ST7-AS1 was significantly Expression[Expression[up-expression]-expression]regulated in LSCC tissues compared with normal tissues .Mechanistically, ST7-AS1 could interact with CARM1, a well characterized protein arginine methyltransferase and protect CARM1 from ubiquitin-dependent degradation. CARM1 can methylate Sox-2, a pluripotent transcription factor. Meanwhile, higher ST7-AS1 expression also positively correlated with advanced TNM stages (Fig. 1C), metastasis (Fig. 1D) smoking and drinking status (Table S3). Notably, age and gender were not significantly associated with ST7-AS1 expression (Table S3). Furthermore, higher ST7-AS1 level also predicted poor survival Yes Then, ST7-AS1 silence inhibited migration in both TU-212 and Hep-2 cells (Fig. 2A and B). Consistently, Expression[Expression[up-expression]-expression]regulating ST7-AS1 expression enhanced the migratory capacity in TU-212 and Hep-2 cells (Fig. 2A and B). 30853182 ST3GAL6-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[PI3K/Akt signaling] qRT-PCR Here, we found that ST3Gal6-AS1 and ST3Gal6 levels were lower in tumor tissues than adjacent normal tissues of CRC patients. In addition, ST3Gal6 was dysregulated and positively correlated to ST3Gal6-AS1. ST3Gal6-AS1 recruited histone methyltransferase MLL1 to the promoter region of ST3Gal6, induced H3K4me3 modification and activated ST3Gal6 transcription. Furthermore, ST3Gal6-AS1/ST3Gal6 axis mediated α-2, 3 sialylation and inhibited the activation of PI3K/Akt signaling, thereby resulting in Foxo1 nuclear translocation in CRC cells. ST3Gal6-AS1 was a target of transcription factor Foxo1 and regulated by Foxo1. ST3Gal6-AS1 expression was negatively correlated with tumor size, lymphatic metastasis, distant metastasis and tumor stage in CRC patients. Yes ST3Gal6-AS1 also inhibited CRC cell proliferation, metastasis, and promoted cell apoptosis in vitro. Overexpression of ST3Gal6-AS1 significantly decreased the tumorigenesis, lung and liver metastasis of SW620 cells in vivo. 30613961 ST3GAL6-AS1 LncRNA Homo sapiens Multiple Myeloma plasma Expression[highly expressed] qRT-PCR//Western Blot We documented a high ST3GAL6-AS1 expression level in MM compared to normal plasma cells (PCs) or other hematological malignancies. Yes ST3GAL6-AS1 silencing by LNA-gapmeR antisense oligonucleotides inhibits cell proliferation and triggers apoptosis in MM cell line. 32218309 STARD13-AS LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] Flow Cytometry//qRT-PCR//MTT//Transwell Assay Bioinformatics prediction and qRT-PCR results showed that STARD13-AS expression was decreased in CRC tissues. Patients with low STARD13-AS expression exhibited distant and lymphatic metastasis as well as enhancement in tumor size. Yes Moreover, we observed that while STARD13-AS overexpression suppressed the cell cycle, proliferation, migration, and invasion, while promoted apoptosis both in LoVo and SW620 cells. 31807011 STEAP3-AS1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues and cell lines regulation[STEAP3 ] qRT-PCR STEAP3-AS1 is located in physical contiguity with STEAP3 and notably increased in colon cancer tissues and cell lines. Mechanistic investigations demonstrated that STEAP3-AS1 downregulation could increase the expression of cyclin-dependent kinase inhibitor 1C (CDKN1C) by STEAP3 upregulation. Yes In in vitro assays, STEAP3-AS1 knockdown could inhibit colon cancer cell proliferation and migration and arrest colon cancer cells at the G0-G1 phase. In tumorigenicity assays, STEAP3-AS1 knockdown could strongly inhibit tumor growth. 32679543 ST3GAL6 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(FOXP2/MET/mTOR axis) colony Formation Assay//Western Blot//Transfection//IF//IP//Colony Formation Assay//Transwell Assay In our study, circST3GAL6 was significantly downregulated in GC and was associated with poor prognosis in GC patients. In addition, we demonstrated that circST3GAL6 regulated FOXP2 through the mir-300 sponge. We further found that FOXP2 inhibited MET Proto-Oncogene (MET), which was the initiating factor that regulated the classic AKT/mTOR pathway of autophagy. In conclusion, our results suggested that circST3GAL6 played a tumour suppressive role in gastric cancer through miR-300/FOXP2 axis and regulated apoptosis and autophagy through FOXP2-mediated transcriptional inhibition of the MET axis, which may become a potential target for GC therapy. In our study, circST3GAL6 was significantly downregulated in GC and was associated with poor prognosis in GC patients. Yes Overexpression of circST3GAL6 inhibited the malignant behaviours of GC cells, which was mediated by inducing apoptosis and autophagy. 35061934 hsa_circ_100395 CircRNA Homo sapiens Breast Neoplasms breast carcinoma tissues and cell lines regulation[targeting MAPK6] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircRNA_100395 was downregulated in breast carcinoma tissues and cell lines.CircRNA_100395 serves as an anti-cancer gene in breast carcinoma progression by targeting MAPK6, and its level is negatively correlated to tumor staging and tumor size of breast carcinoma. Its level was negatively correlated to tumor staging and tumor size of breast carcinoma. Yes Overexpression of circRNA_100395 in SKBR3 and MDA-MB-231 cells weakened proliferative and migratory abilities. 33336740 hsa_circ_0058106 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Interaction(miR-185-3p) Western Blot//Wound Healing Assay//EdU Staining//Migration Assay//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay The results showed circ_0058106 expression level was significantly upregulated in tumor tissues than in corresponding normal tissues. Bioinformatics predicted circ_0058106 may interact with miR-185-3p. Moreover, we proved circ_0058106 promoted HSCC cells tumorigenesis and EMT process by regulating Wnt2b/β-catenin/c-Myc pathway via miR-185-3p. Yes We found that circ_0058106 upregulation promoted proliferation, migration and invasion of HSCC cells, while knockdown of circ_0058106 inhibited proliferation, migration and invasion of HSCC cells both in vitro and in vivo. Moreover, we proved circ_0058106 promoted HSCC cells tumorigenesis and EMT process by regulating Wnt2b/β-catenin/c-Myc pathway via miR-185-3p. 34750351 hsa_circ_0060,144 CircRNA Homo sapiens Cataract ARC tissues Interaction(miR-23b-3p/HIPK3 axis) RNA Pull-Down//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining Circ_0060,144 and HIPK3 mRNA expression were decreased in ARC tissues, and miR-23b-3p was increased. In addition, circ_0060,144 overexpression reduced MDA level and increased GSH-Px level. In terms of mechanism, circ_0060,144 inhibited HIPK3 expression via sponging miR-23b-3p. Yes Circ_0060,144 overexpression promoted proliferation and inhibited apoptosis of SRA01/04 cells. And proliferation-related and apoptosis-related proteins also confirmed this conclusion. 35810770 hsa_circ_0043144 CircRNA Homo sapiens Vitreoretinopathy, Proliferative blood Expression[highly expressed] Cell Proliferation Assay//qRT-PCR//migration assay//Microarray circ_0043144 was significantly up-regulated in the vitreous samples and the corresponding serum samples of the patients with PVR. Yes circ_0043144 expression was significantly down-regulated after PVR operation. In vitro studies revealed that circ_0043144 was involved in the regulation of the proliferation, migration and secretion ability of ARPE-19 cells, which is critical for ERM formation. 30597308 hsa_circ_0002060 CircRNA Homo sapiens Osteoporosis hFOB 1.19 Interaction(MiR-198-5p) CCK8//ELISA//Western Blot The results indicated DEX could induce cell viability decline in hFOB 1.19 cells, which was ameliorated by hsa_circ_0002060 knockdown. Consistently, DEX-induced cell apoptosis of hFOB 1.19 was ameliorated by hsa_circ_0002060 knockdown as well. As for the underlying mechanisms study, hsa_circ_0002060 was proved to regulate the viability of hFOB 1.19 cells through targeting miR-198-5p/Bax axis. Additionally, hsa_circ_0002060 knockdown alleviated ovariectomy-induced OP in a mouse model. Taken together, hsa_circ_0002060 knockdown alleviated the progression of OP by targeting miR-198-5p. Yes As for the underlying mechanisms study, hsa_circ_0002060 was proved to regulate the viability of hFOB 1.19 cells through targeting miR-198-5p/Bax axis. Additionally, hsa_circ_0002060 knockdown alleviated ovariectomy-induced OP in a mouse model. Taken together, hsa_circ_0002060 knockdown alleviated the progression of OP by targeting miR-198-5p. 33148890 circRPPH1 CircRNA Homo sapiens Breast Neoplasms 44 Tumor tissues and adjacent tissues Interaction(miR-146b-3p/E2F2 pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//RIP//qRT-PCR//FISH//Cell Apoptosis Assay circ_RPPH1 was evidently enhanced in BC, and its content was related to the clinical stage and pathological grade. Mechanism exploration indicated that circ_RPPH1 acted as ceRNA (competing endogenous RNA) of miR-146b-3p, so as to reduce the inhibitory role of miR-146b-3p on its target E2F2. its content was related to the clinical stage and pathological grade. Yes circ_RPPH1 can accelerate the proliferation, migration and invasion, and promote tumorigenesis and metastasis. 34433131 SYNE3 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression(highly expressed) CCK8//qRT-PCR The results demonstrated that LINC00341 was overexpressed in bladder cancer in contrast with the healthy tissues. The LINC00341 expression level in high-grade tumors was higher in contrast with that in low-grade tumors. Yes In T24 as well as 5637-cell lines harboring LINC00341-sgRNA, inhibition of cell proliferation (in vitro and in vivo), elevated apoptosis rate and diminished migration ability. Moreover, silencing LINC00341 upregulated the expressions of p21, Bax as well as E-cadherin. Knockout of these genes could eliminate the phenotypic changes caused by sgRNA targeting LINC00341. 33855047 SWINGN LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Regulation[miR-665/AKT3 axis] CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay Expression level of LINC00565 in GC tissue was highly expressed in GC, which was negatively correlated to prognosis of GC patients.LINC00565 can be used as the sponge of miR-665 to up-regulate the expression of AKT3, thus promoting the progression of GC. Expression level of LINC00565 in GC tissue was highly expressed in GC, which was negatively correlated to prognosis of GC patients. Yes The results showed that knockdown of LINC00565 decreased proliferative and colony formation abilities, and induced apoptosis of GC cells. 31576144 SWINGN LncRNA Homo sapiens Ovarian Neoplasms ovarian tissues and cell lines Interaction[Targeting GAS6] Flow Cytometry//qRT-PCR//Western Blot In this research, we discovered that LINC00565, a novel lncRNA, was highly expressed in ovarian cancer (OC).In summary, our study firstly reported that the LINC00565 functioned as an oncogene to promote the progression of OC by interacting with GAS6. LINC00565 expression level was negatively associated with outcomes of OC patients. Further analysis showed that LINC00565 expression was closely correlated to tumor size, FIGO stage, but not related to other clinical features. Yes In vitro experiments indicated that knockdown of LINC00565 significantly inhibited proliferative, invasive and migratory abilities of ovarian cancer cells. Besides, knockdown of LINC00565 can induce cell cycle arrest in G0/G1 phase. In addition, in vivo assay showed that low expression of LINC00565 inhibited the growth of OC. 31819497 SUMO1P3 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[ Wnt/β-catenin signaling pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay The expression of SUMO1P3 was significantly upregulated in GC tissues and cell lines. SUMO1P3 may promote invasion, migration, and cycle progression of SGC-7901 and MKN45 cells by enhancing the Wnt/β-catenin pathway. Yes Downregulation of SUMO1P3 significantly inhibited the SGC-7901 and MKN45 cell proliferation, invasion, migration, and cycle progression and promoted the cell apoptosis, while overexpression of SUMO1P3 showed the opposite effect. 33179980 STMN1P2-201 LncRNA Homo sapiens Breast Neoplasms breast cancer cells and tissues Interaction(FXR1) RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//RIP//Transwell Assay Here, we report a newly discovered lncRNA, ENST00000508435, which could be remarkably up-regulated in breast cancer cells and tissues. RNA pull-down and RNA immunoprecipitation assays demonstrated that ENST00000508435 could directly bind to FXR1 to promote tumor metastasis. ENST00000508435 and FXR1 were positively correlated. FXR1 was also significantly up-regulated in breast tumors. Taken together, we propose that ENST00000508435 regulates FXR1 to promote breast cancer metastasis. We found that the expression of ENST00000508435 was positively correlated with tumor size, lymph node metastasis and HER2. Yes More interesting, overexpression of ENST00000508435 significantly increased cell migration, while specific knockdown led to the opposite. 34057025 SUMO1P3 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Interaction[silencing CPEB3 ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Colony Formation Assay//ChIP It was found by qRT-PCR that SUMO1P3 exhibited higher levels in CRC tissues (n = 72) than the paired adjacent non-cancerous ones (n = 72). Cytoplasmic polyadenylation element binding protein 3 (CPEB3) has been newly acknowledged as a tumor suppressive gene in several cancers, and has been revealed to present low expression in CRC. We predicted through UCSC database and validated by ChIP assay that EZH2, a crucial regulator of trimethylation of histone H3 at lysine 27 (H3K27me3), bound to CPEB3 promoter. Further, we validated that SUMO1P3 epigenetically repressed CPEB3 through EZH2. Finally, rescue assays indicated that SUMO1P3 provoked proliferation, cell cycle, and retarded apoptosis through CPEB3. Yes The loss-of-function assays suggested that SUMO1P3 provoked CRC cell proliferative ability, and retarded apoptotic ability. 30799082 SUMO1P3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Expression[highly expressed] Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Invasion Assay We found that SUMO1P3 was significantly upregulated in HCC tissues and cells. Yes Furthermore, SUMO1P3 knockdown markedly suppressed cell proliferation, colony formation ability, and cell invasiveness, promoted apoptosis, and enhanced radiosensitivity of HCC cells. 29905911 SUMO1P3 LncRNA Homo sapiens Glioma glioma tissues and cell lines Expression [highly expressed] Western Blot//Transfection//Wound Healing Assay//Migration Assay//qRT-PCR//Cell Proliferation Assay//Cell Cycle Assay//Invasion Assay The results demonstrated that SUMO1P3 expression was upregulated in glioma tissues and cell lines. In addition, SUMO1P3 promoted glioma by regulating the expression levels of β-catenin, cyclin-D1, N-cadherin and E-cadherin. Furthermore, SUMO1P3 was associated with a poor overall survival of patients with glioma. Yes The results of the in vitro cell proliferation and flow cytometry assays demonstrated that SUMO1P3-knockdown suppressed cell proliferation and cell cycle. The results of the wound healing and Transwell assays demonstrated that SUMO1P3-knockdown significantly repressed cell migration and invasion. 33791000 SUMO1P3 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic tissues Regulation[EMT signaling pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay The results of the present study revealed that SUMO1P3 expression was elevated in pancreatic tissues compared with the corresponding adjacent normal tissues.Taken together, the results of the present study demonstrated that SUMO1P3 may participate in EMT and pancreatic cancer progression, thus suggesting that it may be a novel diagnostic and therapeutic biological target for pancreatic cancer. Additionally, the data indicated that the increased expression of SUMO1P3 is significantly associated with tumor progression and the poor survival of patients with pancreatic cancer. Yes Furthermore, the present study identified that SUMO1P3 knockdown may suppress the proliferation, migration and invasion of pancreatic cancer cells. 30333879 SUMO1P3 LncRNA Homo sapiens Liver Neoplasms HCC tissues and cells Expression[highly expressed] qRT-PCR SUMO1P3 was significantly higher in HCC tissues and cells than in non-cancerous specimens and normal cells. The χ test showed that the SUMO1P 3 expression level was significantly associated with tumor size (P = .031), capsular invasion (P = .011), vascular invasion (P = .004), Edmondson-Steiner grade (P = .002), and TNM stage (P = .001). The patients with high SUMO1P 3 expression showed shorter 5-year overall survival than those with low SUMO1P 3 expression (P = .034; log-rank test). Multivariate regression analysis showed that the status of SUMO1P 3 expression was an independent prognostic factor for overall survival (HR = 2.107, 95% CI: 1.478-9.014, P = .031). Yes SUMO1P3 knockdown inhibited the proliferation, migration, and invasion of HCC cells. 33181633 STXBP5-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Regulation[miR-96-5p/PTEN axis] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay In our study, we showed that the expression of STXBP5-AS1 and PTEN was reduced while miR-96-5p expression was upregulated in CC. Taken together, our findings revealed that STXBP5-AS1 might function as a ceRNA to drive CC cells proliferation and invasion via regulating miR-96-5p/PTEN axis. Yes STXBP5-AS1 overexpression significantly reduced CC cells proliferation and invasion ability by suppressing miR-96-5p expression. 31212131 STXBP5-AS1 LncRNA Homo sapiens Glioma glioma cells and tissues Epigenetics(hypermethylation ) In Vivo Experiment//Western Blot//Transfection//Invasion Assay//Migration Assay//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//IHC//EdU Staining STXBP5-AS1 was downregulated in glioma cells and tissues, and associated with tumor size and clinical stages.Both of two genes were significantly restored in cells treatment with 5-Aza. The promoter CpG island of STXBP5/STXBP5-AS1 was hypermethylated in glioma cells, but partially methylated in NHA cells. We found that promoter methylation frequency was significantly higher in glioma tissues. STXBP5-AS1 was downregulated in glioma cells and tissues, and associated with tumor size and clinical stages. Yes Functionally, overexpression of STXBP5 and STXBP5-AS1 inhibited cell proliferation, migration, and invasion and promoted apoptosis in vitro, whereas depletion of STXBP5 and STXBP5-AS1 showed opposite effects. 33965377 ST3GAL6-AS1 LncRNA Homo sapiens Multiple Myeloma MM cells Interaction(hnRNPA2B1/ST3GAL6 ) RNA Pull-Down//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Invasion Assay Moreover, mechanistic investigation showed that ST3GAL6?AS1 could suppress ST3GAL6 mRNA degradation via interacting with heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1). The present results suggested that upregulated lncRNA ST3GAL6?AS1 promotes adhesion and invasion of MM cells by binding with hnRNPA2B1 to regulate ST3GAL6 expression. Yes It was reported that knockdown of ST3GAL6?AS1 suppressed the adhesion, migration and invasion ability of MM cells in vitro. Expression of ST3GAL6 was significantly reduced when ST3GAL6?AS1 was knock downed in MM cells. 33649796 SRA1 CircRNA Homo sapiens Ovarian Neoplasms Ovarian Cancer tissues Interaction[miR-1252] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray By microarray (5 PTX-resistant ovarian cancer tissues νs 5 PTX-sensitive ovarian cancer tissues) and qRT-PCR (36 normal ovarian tissues and ovarian cancer tissues) we identified circCELSR1 to be dramatically highly expressed in ovarian cancer samples and correlated with PTX resistance. Furthermore, we demonstrated that circCELSR1 acts as a sponge for miR-1252 and verified that forkhead box 2 (FOXR2) is a novel target of miR-1252. Yes Compared with sensitive cell lines, circCELSR1 was also highly expressed in PTX-resistant ovarian cancer cell lines, and circCELSR1 silencing enhanced PTX-induced cytotoxicity in ovarian cancer cells. Meanwhile, the inhibition of circCELSR1 also caused ovarian cancer cell G0/G1 arrest and an increase in apoptosis. In vivo studies revealed that circCELSR1 was stably inhibited in a xenograft mouse model and inhibited the growth of ovarian cancer. 31945729 SOX2-OT LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer patients' plasma exosomes Interaction(miR-181b-5p/SCD1 signaling) Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay we revealed that the SOX2-OT expression levels were up-regulated in the ovarian cancer patients' plasma exosomes. In mechanical exploration, SOX2-OT could sponge miR-181b-5p, and miR-181b-5p was able to target SCD1 in the ovarian cancer cells. Yes The depletion of exosomal SOX2-OT inhibited migration, invasion, and proliferation and induced apoptosis in ovarian cancer cells. 34690112 SOX9-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular Hepatocellular carcinoma tissue Interaction[Wnt/β-catenin pathway] ChIP//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//IF We subsequently identified that the long non-coding RNA (lncRNA) SOX9 antisense RNA 1 (SOX9-AS1) is a neighbor gene to SOX9; SOX9-AS1 is also upregulated in HCC, and its expression is positively correlated with that of SOX9. We demonstrated that SOX9-AS1 sponges miR-5590-3p to elevate SOX9 expression, and that SOX9 in turn transcriptionally activates SOX9-AS1. Moreover, we verified that SOX9-AS1 regulates SOX9 and its known downstream Wnt/β-catenin pathway so as to facilitate epithelial-to-mesenchymal transition. The results of our rescue assays suggest that SOX9-AS1 regulates HCC progression through SOX9 and the Wnt/β-catenin pathway. In addition, SOX9-AS1 appears to have prognostic significance in HCC patients. Yes Here, we confirmed upregulation of SOX9 in HCC tissues and cell lines and validated that SOX9 facilitates proliferation, migration and invasion in HCC. We showed that SOX9-AS1 aggravates HCC progression and metastasis in vitro and in vivo. 31402556 SPINT1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(SPINT1-AS1/miR-433-3p/E2F3 ) RNA Pull-Down//ChIP//Western Blot//Transfection//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay RT-qPCR analysis first confirmed that SPINT1-AS1 exhibited high expression in KRAS-mutant (KRASMUT) CRC cells. Afterwards, the implementation of mechanism assays help to verify that SPINT1-AS1 sequestered microRNA-433-3p (miR-433-3p) to regulate the expression of E2F transcription factor 3 (E2F3). Besides, E2F3 was validated to activate the transcription of SPINT1-AS1 in turn. Rescue experiments confirmed the functional influence of SPINT1-AS1/miR-433-3p/E2F3 on CRC cells. Yes Through series of functional experiments, we observed that knockdown of SPINT1-AS1 weakened KRASMUT CRC cell proliferation, migration and invasion. 36274378 circDNMT3B CircRNA Homo sapiens Diabetic Retinopathy retinal microvascular endothelial cells Interaction[targeting miR-20b-5p and BAMBI] CCK8//qRT-PCR//Transwell Assay Under diabetic conditions, circDNMT3B, which acts as a sponge of miR-20b-5p, is downregulated.Downregulation of circDNMT3B contributes to vascular dysfunction in diabetic retinas through regulating miR-20b-5p and BAMBI, providing a potential treatment strategy for diabetic retinopathy. Yes circDNMT3B overexpression reduced retinal acellular capillary number and alleviated visual damage in diabetic rats. 31636010 hsa_circ_0067301 CircRNA Homo sapiens Epithelial-Mesenchymal Transition EMT tissues Regulation[miR-141/Notch signaling pathway] Western Blot//Wound Healing Assay//qPCR//Transwell Assay//IF We found that relative RNA levels of hsa_circ_0067301 and miR-141-5p were significantly reduced in ectopic endometrium when compared to control endometrium. Results demonstrate the hsa_circ_0067301/miR-141-5p/Notch-1 axis plays an important regulatory role in the process of EMT in endometriosis. Yes Hsa_circ_0067301 knockdown could promote the proliferation and migration in Ishikawa and End1/E6E7 cells, concomitant with increased the relative protein expression against Notch-1, Hes-1, N-cadherin, and vimentin but reduced expression of E-cadherin. 31023528 hsa_circ_0138959 CircRNA Homo sapiens Periodontitis periodontitis tissues and LPS-treated PDLC Interaction(Circ_0138959/miR-495-3p/TRAF6 axis) Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//ELISA Circ_0138959 was overexpressed in periodontitis tissues and LPS-treated PDLCs.Circ_0138959 acted as a miR-495-3p sponge, and the regulatory role of circ_0138959 in LPS-induced cell injury was achieved by sponging miR-495-3p. Additionally, miR-495-3p targeted TNF Receptor Associated Factor 6 (TRAF6) and miR-495-3p protected against LPS-induced cell dysfunction by targeting TRAF6. Circ_0138959 upregulated TRAF6 level via inhibiting miR-495-3p. Yes Downregulation of circ_0138959 attenuated LPS-induced inhibition of proliferation, wound healing and osteogenic differentiation but promotion of apoptosis and inflammation. 35784154 hsa_circ_0099630 CircRNA Homo sapiens Periodontitis human PDL cells Interaction(miR-940/TRAF6/NF-κB ) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//ELISA//EdU Staining Higher abundance of circ_0099630 and TRAF6 and lower miR-940 expression were observed in periodontitis, and circ_0099630 knockdown attenuated the damage of human PDL cells (PDLCs) induced by lipopolysaccharides (LPS). The relationship between miR-940 and circ_0099630 or TRAF6 was evidenced, while miR-940 downregulation diminished the repair effect of si-circ_0099630 on overexpression LPS-induced damage in PDLCs. Similarly, TRAF6 upregulation impaired the mitigating effect of miR-940 overexpression on LPS-induced injury in PDLCs. Circ_0099630 silencing evidently curbed the phosphorylation levels of P65 and IκBα and thus attenuating the inflammatory response by acting on the miR-940/TRAF6 axis. Yes Higher abundance of circ_0099630 and TRAF6 and lower miR-940 expression were observed in periodontitis, and circ_0099630 knockdown attenuated the damage of human PDL cells (PDLCs) induced by lipopolysaccharides (LPS). The relationship between miR-940 and circ_0099630 or TRAF6 was evidenced, while miR-940 downregulation diminished the repair effect of si-circ_0099630 on overexpression LPS-induced damage in PDLCs. 36299308 SPAAR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction[miR-5581-3p/CRLS1] qRT-PCR Herein, we revealed a marked downregulation of LINC00961 in HCC tissues and cell lines.On the whole, our findings disclosed that LINC00961 played a suppressive role in HCC progression via modulating miR-5581-3p/CRLS1, thus providing a potentially effective target for the prognosis and treatment of patients with HCC. Yes Functionally, LINC00961 overexpression obviously inhibited cell proliferation, migration, and invasion in HCC cells. 30825207 SPAAR LncRNA Homo sapiens Glioma glioma tissues and cell lines Expression[lower expressed] qRT-PCR//Western Blot We found that LINC00961 was significantly downregulated in glioma tissues and cell lines compared with that of adjacent normal brain tissues and normal human astrocytes. Low expression of LINC00961 was significantly correlated with WHO grade and KPS score. Clinical analysis indicated that patients with low LINC00961 expression had a shorter overall survival than those with high expression. Yes Functionally, overexpression of LINC00961 significantly suppressed glioma cells proliferation, migration, and invasion. 30070327 hsa_circ_3302 CircRNA Homo sapiens Mucocutaneous Lymph Node Syndrome KD serum Interaction(miR-135b-5p) In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//IF//Luciferase Report Assay//H&E Staining//Transwell Assay Our data demonstrated that circRNA-3302 contributed to the KD-associated EndMT via sponging miR-135b-5p to enhance KIT expression. Yes Moreover, in vitro experiments demonstrated that overexpression of circRNA-3302 could markedly induce EndMT, and silencing of circRNA-3302 significantly alleviated KD serum-mediated EndMT. 35768408 hsa_circ_0093741 CircRNA Homo sapiens Wilms Tumor nephroblastoma tissues and cells Interaction( miR-562/FRS2 axis) In Vivo Experiment//IHC//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Hsa_circ_0093741 was highly expressed in nephroblastoma tissues and cells. Knockdown of hsa_circ_0093741 suppresses nephroblastoma cell growth, migration and invasion by regulating the miR-562/FRS2 axis, suggesting the potential involvement of hsa_circ_0093741 in nephroblastoma progression. Yes Functionally, hsa_circ_0093741 silencing significantly suppressed the growth, invasion, and migration of nephroblastoma cells in vitro. 36286392 SPINT1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-214/HDGF ) Western Blot//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay It was found that SPINT1-AS1 was upregulated in CRC and contributed to the poor prognosis of CRC patients. Furthermore, we found that SP1 could activate SPINT1-AS1 by acting as a transcription factor. Meanwhile, we identified miR-214 was negatively regulated by SPINT1-AS1. Furthermore, miR-214 repression restored the suppressive effects on malignant biological behaviors of CRC caused by SPINT1-AS1 silencing. In addition, SPINT1-AS1 mediated HDGF expression through targeting miR-214. Finally, overexpressed heparin-binding growth factor (HDGF) overturned the effects on viability, metastasis, and apoptosis of CRC cells induced by SPINT1-AS1 depletion or miR-214 upregulation. It was found that SPINT1-AS1 was upregulated in CRC and contributed to the poor prognosis of CRC patients. Yes Silencing of SPINT1-AS1 inhibited proliferation and metastasis but increased apoptosis of CRC cells. 35068341 SOX4 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells regulation[ circ-SOX4/miR-1270/PLAGL2 axis,WNT signaling pathway] qPCR//RIP//PCR//IP//IF Circ-SOX4 was found to be obviously upregulated in LUAD tissues and cells, and knockdown of it inhibited cell proliferation, invasion and migration in LUAD.Additionally, it was discovered that circ-SOX4/miR-1270/PLAGL2 axis activated WNT signaling pathway in LUAD. Yes Circ-SOX4 was found to be obviously upregulated in LUAD tissues and cells, and knockdown of it inhibited cell proliferation, invasion and migration in LUAD.urthermore, silenced circ-SOX4 also inhibited LUAD tumor growth. 31911754 hsa_circ_0044226 CircRNA Homo sapiens Pulmonary Fibrosis lung tissues regulation[inhibiting CDC27] qRT-PCR The results identified 45 DEcircRNAs, among which expression of hsa_circ_0044226 was markedly higher in lung tissues from IPF patients than from healthy controls.Collectively then, these findings indicate that downregulation of hsa_circ_0044226 attenuates pulmonary fibrosis in vitro and in vivo by inhibiting CDC27, which in turn suppresses EMT. Yes This suggests CDC27 overexpression abolishes the antifibrotic effect of hsa_circ_0044226 knockdown through activation of EMT. 32710728 circMATR3 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HSCC tissues Expression[highly expressed] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay We found that circMATR3 was up-regulated in HSCC tissues, and abundant circMATR3 expression was markedly correlated with late T classification, advanced clinical stage, greater lymph node metastasis, and poor prognosis. We found that circMATR3 was up-regulated in HSCC tissues, and abundant circMATR3 expression was markedly correlated with late T classification, advanced clinical stage, greater lymph node metastasis, and poor prognosis. Yes Furthermore, knock-down of circMATR3 significantly inhibited proliferation, migration and invasion of HSCC cells, whereas silencing of circMATR3 induced cell apoptosis. 32166857 SOX2-OT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung peripheral blood of NSCLC patients with BoM Interaction(miRNA-194-5p/RAC1 signalling axis) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay//IHC In this study, we found that lncRNA-SOX2OT was highly accumulated in exosomes derived from the peripheral blood of NSCLC patients with BoM and that patients with higher expression of exosomal lncRNA-SOX2OT had significantly shorter overall survival. Mechanistically, we discovered that NSCLC cell-derived exosomal lncRNA-SOX2OT modulated osteoclast differentiation and stimulated BoM by targeting the miRNA-194-5p/RAC1 signalling axis and TGF-β/pTHrP/RANKL signalling pathway in osteoclasts. In this study, we found that lncRNA-SOX2OT was highly accumulated in exosomes derived from the peripheral blood of NSCLC patients with BoM and that patients with higher expression of exosomal lncRNA-SOX2OT had significantly shorter overall survival. Yes Additionally, exosomal lncRNA-SOX2OT derived from NSCLC cells promoted cell invasion and migration in vitro, as well as BoM in vivo. 34215717 SOX2-OT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-30d-5p/PDK1/PD-L1) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay The results expressed that in NSCLC, SOX2-OT, and PDK1 were notably overexpressed while miR-30d-5p was markedly under-expressed.Then, the combined application of overexpressed PDK1 and rapamycin verified that PDK1 could regulate the expression of PD-L1 in NSCLC cells through the mTOR signaling pathway. Co-culture of CD8+ T cells verified that silencing SOX2-OT could inhibit the apoptosis of CD8+ T cells through miR-30d-5p/PDK1. Yes we revealed that inhibiting the expression of SOX2-OT could inhibit the proliferation, migration and invasion of NSCLC cells and promote cell apoptosis; while simultaneous overexpression of PDK1 or inhibition of miR-30d-5p expression could reverse the inhibitory effect of SOX2-OT silence-mediated malignant progression of NSCLC cells. Finally, tumor formation assay in animals confirmed that overexpression of SOX2-OT could promote the growth of NSCLC tumor in vivo. 34394184 SOX2-OT LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-194-5p/SOX5 axis) CCK8//qRT-PCR//Western Blot The results showed SOX2OT was an oncogene that was up-regulated in human CRC tissues and cell lines.Bioinformatic predictive analysis coupled with the dual-luciferase reporter, RNA immunoprecipitation (RIP), and functional rescue assay elucidated the mechanistic network of the SOX2OT-miR-194-5p-SOX5 axis in CRC. Yes SOX2OT silencing suppressed cell proliferation, migration, and invasion in CRC cells in vitro, and inhibited tumorigenesis in the mouse xenografts. 33993197 SOX2-OT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR//Transwell Assay It was indicated that lncRNA Sox2ot expression levels were significantly higher in HCC tissues compared with adjacent non-tumor tissues. Increased expression levels of lncRNA Sox2ot were associated with the tumor size, the tumor number and vein invasion in patients with HCC. An association was observed between lncRNA Sox2ot and the DFS and OS of patients with HCC. Yes Furthermore, it was determined that cell invasion was inhibited following the siRNA knockdown of lncRNA Sox2ot in MHCC97H and SMCC-7721 cells via transwell cell invasion assays. 29963193 SOX2-OT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Interaction(miR-143-3p/MSI2) CCK8//qRT-PCR//Western Blot SOX2-OT was highly expressed in HCC cells and tissues. SOX2-OT bound to miR-143-3p to promote MSI2 expression. Downregulating miR-143-3p or upregulating MSI2 averted the role of si-SOX2-OT in HCC cells The prognosis was poor in HCC patients with high SOX2-OT expression. Yes Downregulating SOX2-OT inhibited HCC cell malignant behaviors. Nude mouse subcutaneous tumorigenesis showed that SOX2-OT downregulation decreased the tumorigenicity of HCC, and affected the levels of miR-143-3p and MSI2 mRNA in tumor tissues. 34322386 SPINT1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms Ninety-two pairs of cervical cancer tissues and adjacent normal cervical tissues Interaction(miR-214) In Vivo Experiment//Western Blot//Transfection//Invasion Assay//Migration Assay//RIP//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis SPINT1-AS1 was increased in cervical cancer and correlated with advanced stage and poor prognosis. SPINT1-AS1 was a direct downstream target of miR-214, a well-known tumor suppressive microRNA (miRNA) in cervical cancer. SPINT1-AS1 was increased in cervical cancer and correlated with advanced stage and poor prognosis. Yes Functionally, SPINT1-AS1 drove cervical cancer cellular proliferation, migration, and invasion in vitro, and also tumorigenesis in vivo.  34350182 SPINT1-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer patients and breast cancer cell lines Interaction(let-7 a/b/i-5p ) Wound Healing Assay//Invasion Assay//Migration Assay//CCK8//Flow Cytometry//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay SPINT1-AS1 is up-regulated in the serum of breast cancer patients and breast cancer cell lines. The proliferation and migration ability of breast cancer cells were decreased significantly after SPINT1-AS1 knockdown, and it may inhibit its expression by sponging miR-let-7a/b/i-5p, thereby promoting breast cancer progression. Yes The proliferation and migration ability of breast cancer cells were decreased significantly after SPINT1-AS1 knockdown, and it may inhibit its expression by sponging miR-let-7a/b/i-5p, thereby promoting breast cancer progression. 33246290 SRA1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cell line (SKOV3) Expression [highly expressed] In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//H&E Staining The expression of SRA in ovarian cancer was high and correlated with poor prognosis Further, clinical data confirmed that SRA was a significant predictor of overall survival (OS) and progression-free survival and patients with ovarian cancer exhibiting high expression of SRA exhibited higher recurrence rates than patients with low SRA expression. Yes In ovarian cancer cell lines, SRA knockdown and overexpression regulated cell migration, proliferation, and invasion. Both in vivo and in vitro experiments using knockdown and overexpression showed that SRA potently regulated epithelial-mesenchymal transition (EMT) and NOTCH pathway components. 34402503 hsa_circ_0001666 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Interaction(miR-330-5p/HMGA2 axis) RNA Pull-Down//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis The results showed that the expression of circ_0001666 in NSCLC cells was significantly up-regulated than that in normal lung epithelial cells. Circ_0001666 knockdown reduced the cell viability and promoted the apoptosis of NSCLC cells, which could be reversed by miR-330-5p inhibitors. MiR-330-5p is the downstream target of circ_0001666 and can be adsorbed by circ_0001666. Yes Circ_0001666 knockdown reduced the cell viability and promoted the apoptosis of NSCLC cells, which could be reversed by miR-330-5p inhibitors. MiR-330-5p is the downstream target of circ_0001666 and can be adsorbed by circ_0001666. 34230950 SRA1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Expression[lower expressed] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Long noncoding RNA-steroid receptor RNA activator 1 expression was downregulated in osteosarcoma tissues and cells compared with that in corresponding normal tissues, whereas microRNA-208a expression was upregulated in osteosarcoma tissues. Yes Moreover, the restoration of long noncoding RNA steroid receptor RNA activator 1 inhibited cell proliferation, and upregulation of long noncoding RNA steroid receptor RNA activator 1 restrained cell migration and invasion but boosted the apoptosis rate in osteosarcoma cells. 31106680 SRA1 LncRNA Homo sapiens Endometrial Neoplasms endometrial cancer tissues regulation[Wnt/ β-catenin signaling pathway] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Expression levels of SRA were upregulated in endometrial cancer tissues compared to those in adjacent control tissues. These results suggest that SRA is involved in proliferation, migration, and invasion of endometrial cancer cells by increasing the expression of EIF4E-BP1 and activity of Wnt/ β-catenin signaling. Yes In addition, SRA knockdown inhibited the expression of EIF4E-BP1 known to play a critical role in the control of protein synthesis, cell growth, and cell survival, thus promoting tumourigenesis and epithelial-mesenchymal transition (EMT) important for cell motility and metastasis. 31892849 SRA LncRNA Mus musculus Vascular Proliferative Diseases arteries Interaction[MEK-ERK-CREB pathway] Western Blot//Wound Healing Assay//qPCR//H&E Staining//IHC//EdU Staining LncRNA-SRA was overexpressed in the injured arteries, and significantly promoted the expression of ki67, thereby caused an overall increase in neointima formation.By stimulating the phosphorylation of MEK, ERK and CREB (cyclic nucleotide responsive element binding protein), lncRNA-SRA promoted VSMC proliferation. Meanwhile, these effects were blocked by the MEK inhibitor U0126. Therefore, lncRNA-SRA promoted VSMC proliferation by activating the MEK-ERK-CREB pathway. LncRNA-SRA could be a promising therapeutic target in vascular diseases characterized by neointimal hyperplasia. Yes LncRNA-SRA overexpression led to the proliferation and migration of vascular smooth muscle cells (VSMCs). 30822571 SPTY2D1OS LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues and cells Interaction(miR-221) RNA-seq//Invasion Assay We have identified a likely operative post-transcriptional regulatory network in which the downregulated lncRNA, SPTY2D1-AS1, is predicted to target the most abundant and upregulated miRNAs in thyroid cancer, particularly miR-221, a well-known oncomiRNA in cancer. Indeed, SPTY2D1-AS1 functions as a potent tumor suppressor in vitro and in vivo, it is downregulated in the most advanced stages of human thyroid cancer, and it seems to block the processing of the primary form of miR-221. Yes Indeed, SPTY2D1-AS1 functions as a potent tumor suppressor in vitro and in vivo, it is downregulated in the most advanced stages of human thyroid cancer, and it seems to block the processing of the primary form of miR-221. 35562181 SPRY4‑IT1 LncRNA Homo sapiens Osteosarcoma cell lines Interaction[sponging of miR‑101] Western Blot//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay Compared with the hFOB 1.19 cells, SPRY4-IT1 was significantly upregulated in all three OS cell lines (Fig. 1A). Yes SPRY4‑IT1 knockdown or miR‑101 overexpression reduced proliferation, cell cycle progression, survival, migration and invasion of MG‑63 and U2OS cells. 31746422 SPRY4-IT1 LncRNA Homo sapiens Stomach Neoplasms GC Tissues and Cell Lines Interaction[Sponging miR-101-3p ] qRT-PCR//Luciferase Report Assay Here we found that SPRY4-IT1 was upregulated in GC. Altogether, silencing SPRY4-IT1 suppresses the progression of GC by interacting with miR-101-3p and decreasing inhibiting AMPK expression. Yes In vitro experiments revealed that SPRY4-IT1 knockdown significantly inhibited GC cell proliferation by causing G1 arrest and promoting apoptosis, whereas SPRY4-IT1 overexpression promoted cell growth.Further functional assays indicated that SPRY4-IT1 overexpression significantly promoted cell migration and invasion. 31330497 hsa_circ_0008234 CircRNA Homo sapiens gallbladder carcinoma GBC tissues and cells Interaction(miR-204-5p/FGFR2 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay Circ_0008234 and FGFR2 were highly expressed in GBC tissues and cells. In addition, overexpression of FGFR2 restored the cell malignant behavior of GBC cells inhibited by miR-204-5p mimic. Animal experiments confirmed the anti-tumor effect of silenced circ_0008234 in vivo. Yes Silencing circ_0008234 down-regulated cell proliferation, migration and invasion of NOZ and SGC-996 cells, while miR-204-5p inhibitors reversed these effects. 36278816 SPRY4-IT1 LncRNA Homo sapiens Breast Neoplasms cell lines Interaction[ binding miR-6882-3p with TCF7L2] IHC//ISH//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay In our study, SPRY4-IT1 was up-regulated in MCF-7 CSCs compared with MCF-7 cells, and high SPRY4-IT1 expression was related to reduced breast cancer patient survival.Taken together, these findings demonstrated that SPRY4-IT1 promotes proliferation and stemness of breast cancer cells as well as renewal ability and stemness maintenance of BCSCs by increasing the expression of TCF7L2 through targeting miR-6882-3p. In our study, SPRY4-IT1 was up-regulated in MCF-7 CSCs compared with MCF-7 cells, and high SPRY4-IT1 expression was related to reduced breast cancer patient survival. Yes Furthermore, SPRY4-IT1 overexpression promoted breast cancer cell proliferation and stemness in vitro and in vivo. In addition, SPRY4-IT1 knockdown suppressed BCSC renewal ability and stemness maintenance in vivo and in vitro. 31736268 hsa_circ_0000429 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-1197 ) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay Our results showed that circ_0000429 expressions were significantly upregulated in NSCLC tissues and cell lines. Yes Knockdown of circ_0000429 significantly inhibited the cell proliferation, migration, and invasion of NSCLC cells in vitro. Furthermore, we demonstrated that circ_0000429 acted as a sponge to absorb microRNA-1197 (miR-1197) and promoted MADD expression. 33542659 SPRY4-IT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[TNF signaling pathway] qRT-PCR//RNA Pull-Down In this study, we tested the overexpression of SPRY4-IT1 in HCC tissues and cells through a quantitative real-time polymerase chain reaction. In general, our experimental data and analysis demonstrated the role of SPRY4-IT1 in promoting progress and metastasis of HCC by the TNF signaling pathway. Statistical analyses showed that the upregulation had an association with the tumor node metastasis stage, thrombin time, and alkaline phosphatase. Yes Furthermore, SPRY4-IT1 could be involved in cell proliferation, metastasis, and the epithelial-to-mesenchymal transition (EMT) process in HCC in vitro and in vivo. 31943198 SPRY4-IT1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues and cell lines Expression(highly expressed) qRT-PCR//Colony Formation Assay//Western Blot The results demonstrated that SPRY4-IT1 was abnormally upregulated in PDAC tissues and cell lines. Tumor stage and differentiation grade was closely correlated with SPRY4-IT1 expression. Yes Additionally, decreased SPRY4-IT1 contributed to tumor suppressive effect through attenuating cell growth, clonogenic ability and facilitating apoptosis via Bcl-2/caspase-3 pathway in PANC1 and Capan-2 cells. Furthermore, the xenograft study confirmed the tumor proliferation-promoting role of SPRY4-IT1 in PANC1 cells. 29551494 SPRY4-IT1 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Regulation[miR-101-3p/ZEB1 axis] Western Blot//Wound Healing Assay//Luciferase Report Assay//PCR//Transwell Assay SPRY4-IT1 was up-regulated in CC cell lines. Moreover, knockdown of SPRY4-IT1 significantly suppressed the epithelial-mesenchymal transition (EMT) of CC by increased E-cadherin expression and decreased the N-cadherin and vimentin expression. Mechanically, SPRY4-IT1 could directly bind to miR-101-3p and effectively act as a competing endogenous RNA (ceRNA) for miR-101-3p to regulate the expression of the target gene ZEB1Conclusions: Our findings indicate that the SPYR4-IT1/miR-101-3p/ZEB1 axis contributes to CC migration and invasion, which may provide novel insights into the function of lncRNA-driven tumorigenesis of CC. Yes Knockdown of SPRY4-IT1 significantly inhibited CC cells migration and invasion in vitro and in vivo 31092700 SPRY4-IT1 LncRNA Homo sapiens Glioma glioma cells and tissues Interaction(miR-101-3p/EZH2/VEGFA signaling axis) Transfection//Wound Healing Assay//Tube Formation Assay//CCK8//EdU Staining//Transwell Assay Analysis of the TCGA dataset and data from our own cohort demonstrated that SPRY4-IT1 was overexpressed in patients with glioma, and high SPRY4-IT1 expression correlated with poor prognosis. Mechanistically, SPRY4-IT1 upregulated EZH2 expression by sponging miR-101-3p to induce VEGFA expression in glioma cells. Moreover, SPRY4-IT1 activated the VEGFR2/AKT/ERK1/2 pathway in HUVECs mediated by glioma cells. Rescue experiments further confirmed that SPRY4-IT1 promoted glioma cell proliferation and angiogenesis via the miR-101-3p/EZH2/VEGFA signaling axis. Analysis of the TCGA dataset and data from our own cohort demonstrated that SPRY4-IT1 was overexpressed in patients with glioma, and high SPRY4-IT1 expression correlated with poor prognosis. Yes In vitro and in vivo experiments showed that SPRY4-IT1 promoted the proliferation of glioma cells. HUVEC tube forming assay and CAM assay confirmed that SPRY4-IT1 could induce angiogenesis of glioma cells in vitro and in vivo. 36479622 SPRY4-IT1 LncRNA Homo sapiens Nasopharyngeal carcinoma several NPC cell lines (6-10B, CNE-2, and HONE-1) Expression(highly expressed) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//IF//Cell Proliferation Assay//Transwell Assay SPRY4-IT1 was significantly up-regulated in several NPC cell lines (6-10B, CNE-2, and HONE-1) compared with human immortalized nasopharyngeal epithelial cell (NP69). Yes Silencing of SPRY4-IT1 inhibited proliferation, migration, and metastasis, and induced significant G2/M phase arrest and apoptosis. Western blotting showed that the expression levels of cell cycle-related proteins (cyclin B1, cdc2 and p-cdc2) were down-regulated and apoptosis-associated proteins (PARP, cleaved PARP and cleaved caspase-3) were up-regulated after knockdown of SPRY4-IT1. The expression level of E-cadherin was increased and the expression of Vimentin, Snail and Twist1 were decreased after the SPRY4-IT1 knockdown. 35378932 hsa_circ_0093740 CircRNA Homo sapiens Wilms Tumor Wilms tumor cells and tissues Interaction(miR-136/145-DNMT3A axis ) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay A novel circRNA (circ0093740) was identified as a frequently upregulated circRNA in Wilms tumor cells and tissues. The results revealed that circ0093740 promotes the growth and migration ability by sponging miR-136/145 and upregulating DNMT3A. Yes Suppression of circ0093740 remarkably inhibited the proliferation and migration ability in Wilms tumor, validated by several experiments. 34168984 SPRR2C LncRNA Homo sapiens Psoriasis psoriatic lesion samples and HaCaT cell lines Regulation(miR-330/STAT1/S100A7 axis) Transfection//Immunoblotting//qRT-PCR//MTT//H&E Staining//IHC//EdU Staining SPRR2C expression was significantly upregulated in both psoriatic lesion samples and HaCaT cell lines in response to IL-22 treatment. After SPRR2C knockdown, IL-22-induced suppression of HaCaT proliferation, changes in the KRT5/14/1/10 protein levels, and suppression of the IL-1β, IL-6, and TNF-α mRNA levels were dramatically reversed. In the coexpression network with SPRR2C based on GSE114286, miR-330 was significantly negatively correlated with SPRR2C, while STAT1 and S100A7 were positively correlated with SPRR2C. By binding to miR-330, SPRR2C competed with STAT1 and S100A7 to counteract miR-330-mediated suppression of STAT1 and S100A7. MiR-330 overexpression also reversed the IL-22-induced changes in HaCaT cell lines; in response to IL-22 treatment, miR-330 inhibition significantly attenuated the effects of SPRR2C knockdown. STAT1 and S100A7 expression was significantly upregulated in psoriatic lesion samples. The expression of miR-330 had a negative correlation with the expression of SPRR2C, while the expression of SPRR2C had a positive correlation with the expression of STAT1 and S100A7. Thus, SPRR2C modulates the IL-22-stimulated HaCaT cell phenotype through the miR-330/STAT1/S100A7 axis. WGCNA might uncover additional biological pathways that are crucial in the pathogenesis and response to the treatment of psoriasis. Yes After SPRR2C knockdown, IL-22-induced suppression of HaCaT proliferation, changes in the KRT5/14/1/10 protein levels, and suppression of the IL-1β, IL-6, and TNF-α mRNA levels were dramatically reversed. 33452236 SPOCD1-AS LncRNA Homo sapiens Ovarian Neoplasms mesothelial cells Interaction(G3BP1 ) qRT-PCR//RIP//FISH SPOCD1-AS induced the MMT process of mesothelial cells via interacting with G3BP1 protein. Additionally, G3BP1 interfering peptide based on the F380/F382 residues was able to block SPOCD1-AS/G3BP1 interaction, inhibit the MMT phenotype of mesothelial cells, and diminish peritoneal metastasis in vivo. Yes Furthermore, SPOCD1-AS embedded in ovarian cancer-secreted EVs was transmitted to mesothelial cells to induce the MMT process and facilitate peritoneal colonization in vitro and in vivo. 33726799 SNHG8 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-1270 and S100A11) CCK8//qRT-PCR//Luciferase Report Assay SNHG8 has increased expression in OC tissues and cells compared with normal counterparts, and correlated with poorer overall survival of OC patients. In addition, we showed that SNHG8 regulates OC progression through targeting the miR-1270 and S100A11. SNHG8 has increased expression in OC tissues and cells compared with normal counterparts, and correlated with poorer overall survival of OC patients. Yes OC cell proliferation, migration, and invasion abilities were enhanced by SNHG8 overexpression but inhibited by its knockdown. 33491301 SNHG8 LncRNA Homo sapiens Parkinson Disease PD mice, MN9D cells Interaction(miR-421-3p, and miR-421-3p targeted SNX8) CCK8//qRT-PCR//RIP SNHG8 and SNX8 expression levels were decreased while miR-421-3p expression level was increased in the SN of PD mice and rotenone-treated MN9D cells. Mechanistically, SNHG8 bound to miR-421-3p, and miR-421-3p targeted SNX8. Overexpressed SNHG8 downregulates miR-421-3p to alleviate rotenone-induced dopaminergic neuron injury in PD via upregulating SNX8. Yes Upregulated SNHG8 ameliorated dopaminergic neuron damage and locomotor dysfunction in PD mice. Meanwhile, upregulated SNHG8 enhanced viability, diminished apoptosis, and alleviated mitochondrial dysfunction, endoplasmic reticulum stress, and autophagy in rotenone-treated MN9D cells. 36401052 TTN-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction[miR-497-Mediated PI3K/Akt/mTOR Signaling] qRT-PCR//MTT//Western Blot//Transwell Assay We observed a significant increase of TTN-AS1 expression level in CRC tissues and cell lines compared with normal counterparts.Mechanistically, we found that TTN-AS1 could directly interact with miR-497, and co-transfection with miR-497 mimics blocked the activation of PI3K/Akt/mTOR signaling, and reversed the effects of TTN-AS1 overexpression in CRC cells. Yes Functionally, gain- and loss-of-function studies indicated that TTN-AS1 knockdown suppressed the proliferation, migration, invasion and epithelial-mesenchymal transition of CRC cells in vitro, whereas TTN-AS1 overexpression showed the complete opposite effects. 31920341 SNHG5 LncRNA Homo sapiens Colitis, Ulcerative intestinal mucosa tissues Interaction(microRNA-375 / Janus kinase-2 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining SNHG5 was up-regulated in intestinal mucosa tissues of UC patients as well as tumor necrosis factor alpha-treated (TNF-α-treated) young adult mouse colon (YAMC) cells. Additionally, miR-375 targeted JAK2, which was up-regulated by TNF-α treated YAMC cells. Up-regulation of JAK2 induced the dysfunction of YAMC cells. Knockdown of SNHG5 promoted the proliferation and suppressed the apoptosis of YAMC cells via regulating miR-375/JAK2 axis. Therefore, knockdown of SNHG5 may be a promising therapy for UC. Yes Down-regulated SNHG5 promoted cell proliferation and inhibited apoptosis of YAMC cells. miR-375 was verified to be a target of SNHG5 and was suppressed by TNF-α treatment in YAMC cells. Over-expression of miR-375 restored YAMC cellular functions. 34334085 SNHG5 LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[Wnt/CTNNB1 signaling pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Invasion Assay SNHG5 gene was high-expressed in glioma tissues and cell lines.SNHG5 gene was high-expressed in glioma, knockdown of SNHG5 inhibits malignant cellular phenotypes of glioma via Wnt/CTNNB1 signaling pathway. Yes Knockdown of SNHG5 gene depressed cell proliferation and invasiveness as well as promoted the apoptosis of U251 and U87 cells. 30854143 SNHG5 LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[miR-205/E2F3 axis] RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//IF//Luciferase Report Assay//Transwell Assay First, we found that SNHG5 expression was higher in glioma and was related to glioma glucose uptake, migration and invasion. Taken together, our results show that the SNHG5/miR-205/E2F3 axis is involved in glioma progression and may provide a new therapeutic target for the diagnosis and therapy of glioma. Yes Third, using a xenograft mouse model, we demonstrated that SNHG5 regulates tumourigenesis in vivo 31292168 SNHG5 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues regulation[ miR-1179/HMGB3 axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Upregulation of lncRNA-SNHG5 and downregulation of miR-1179 were identified in NPC, which were associated with adverse clinical outcomes. LncRNA SNHG5 serves as a tumor promoter in NPC by sponging miR-1179 and upregulating HMGB3. Yes Functionally, upregulation of lncRNA-SNHG5 and downregulation of miR-1179 accelerated NPC cell proliferation, migration and invasion. 32131767 SNHG5 LncRNA Homo sapiens Glioblastoma Regulation[p38/MAPK signaling pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining//ChIP SNHG5 was highly expressed in GBM.YY1-induced SNHG5 promoted the cell proliferation in GBM via p38/MAPK signaling pathway. The findings expanded our understanding of SNHG5 as an oncogene in GBM. Yes Loss- and gain-of-function assays revealed that SNHG5 promoted GBM cell proliferation and inhibited cell apoptosis in GBM. 31657621 SNHG5 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues regulation[miR-363-3p-Twist1 interaction] qRT-PCR//Luciferase Report Assay We found that lncRNA SNHG5 is upregulated in human ccRCC tissues and that lncRNA SNHG5 inhibition reduced ccRCC cell invasion and promoted apoptosis in vitro. Additionally, functional assays demonstrated that SNHG5 promotes cell invasion and inhibits apoptosis, while miR-363-3p inhibits cell invasion and promotes apoptosis via an interaction with Twist1. Yes We found that lncRNA SNHG5 is upregulated in human ccRCC tissues and that lncRNA SNHG5 inhibition reduced ccRCC cell invasion and promoted apoptosis in vitro. 32194916 SNHG5 LncRNA Homo sapiens Melanoma melanoma tissues and cell lines Interaction[miR-26a-5p/TRPC3 pathway ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay The results showed that SNHG5 expression was increased in melanoma tumor tissues and cell lines. SNHG5 promoted melanoma development by inhibiting miR-26a-5p and facilitating TRPC3 expression, highlighting the potential of SNHG5 as a novel target therapy for melanoma. Yes SNHG5 downregulation repressed proliferation, promoted apoptosis, and decreased invasion in melanoma cells, while these effects were greatly counteracted by miR-26a-5p inhibitor. 30636880 SNHG5 LncRNA Homo sapiens Endometrial Neoplasms EC tissues Regulation[miR-25-3p/BTG2 Axis ] Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay The results of the analysis showed that SNHG5 exhibited significantly lower expression in EC tumor tissues compared to normal tissues (Figure 1(a)). Furthermore, in stage 4 tumors, a significantly lower level of SNHG5 was observed than in early-stage tumors (Figure 1(b)). In summary, for the first time, we report that the SNHG5/miR-25-3p/BTG2 axis plays an important role in EC progression and is of great potential clinical significance for EC diagnosis and therapy. In addition, survival analysis showed that the low expression of SNHG5 was a poor-prognostic factor that negatively correlated with the overall survival and disease-free survival of EC patients (Figure 1(c)). Yes In this study, we demonstrated that the noncoding RNA SNHG5 can inhibit the proliferation, migration, and invasion of EC cells by suppressing the expression of its putative target miR-25-3p. 31885582 SNHG5 LncRNA Homo sapiens Esophageal Neoplasms ESCC tissues and cell lines Regulation(MTA2) In Vivo Experiment//Western Blot//Co-IP//Migration Assay//qRT-PCR//Cell Proliferation Assay//Invasion Assay//Transwell Assay SNHG5 was found to be downregulated in human ESCC tissues and cell lines, and this downregulation was associated with cancer progression, clinical outcomes and survival rates of ESCC patients. . Notably, we found that metastasis-associated protein 2 (MTA2) was pulled down by SNHG5 in ESCC cells using RNA pulldown assay. In addition, overexpression of SNHG5 downregulated the transcription of MTA2 and caused its ubiquitin-mediated degradation. SNHG5 was found to be downregulated in human ESCC tissues and cell lines, and this downregulation was associated with cancer progression, clinical outcomes and survival rates of ESCC patients. Yes Furthermore, we also found that overexpression of SNHG5 significantly inhibited the proliferation, migration and invasion of ESCC cells in vivo and in vitro. 33095847 SNHG5 LncRNA Homo sapiens Aortic Aneurysm, Abdominal (GEO)49 AAA patients and 10 control aortic specimens Interaction(mir‐205‐5p/SMAD4) Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay SNHG5 was downregulated in the AAA and acts as a molecular sponge for mir‐205. Downregulation of SNHG5 induces expression of mir‐205‐5p. Increased mir‐205‐5p expression level inhibits SMAD4 production, thus inhibiting proliferation and migration and promotes apoptosis of smooth muscle cells. Yes Increased mir‐205‐5p expression level inhibits SMAD4 production, thus inhibiting proliferation and migration and promotes apoptosis of smooth muscle cells. 34185955 SNHG5 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction(miR-132/SOX4 pathway) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//EdU Staining//Transwell Assay SNHG5 and SOX4 were upregulated, and miR-132 was downregulated in CC tissues and cell lines. SNHG5 was positively correlated with FIGO stage (p = .003) and lymph node metastasis (p = .001). Yes Pearson's correlation analysis conveyed that SNHG5 was positively correlated with SOX4, and miR-132 was negatively correlated with SOX4 and SNHG5. Knockdown of SNHG5 in vitro reduced CC cell proliferation, migration and invasion through regulating miR-132. 33622094 SNHG5 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBC cells and tissues Interaction(miR-181-5p/XIAP) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay SNHG5 was significantly upregulated in diffuse large B cell lymphoma tissues. LncRNA SNHG5 acted as a ceRNA through binding with miR-181-5p in DLBC cells. Yes Knockdown of SNHG5 inhibited the proliferation, migration, and invasion of diffuse large B cell lymphoma cells in vitro and in vivo. 35154447 SNHG5 LncRNA Homo sapiens Respiratory Distress Syndrome blood regulation[miR-205/COMMD1 axis] qRT-PCR//MTT//Luciferase Report Assay//Western Blot SNHG5 was downregulated, while miR-205 was upregulated in the serum of ARDS patients and lung tissues of LPS-induced mice.SNHG5 acted as a sponge for miR-205 to ameliorate LPS-induced ARDS by regulating COMMD1. Yes Upregulation of SNHG5 or down-regulation of miR-205 inhibited inflammation and promoted the viability of LPS-induced A549 cells. 33170429 SNHG5 LncRNA Homo sapiens Leukemia, Myeloid, Acute cell line regulation[miR-26b/CTGF/VEGFA axis ] IHC//ChIP//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The results showed that lncRNA SNHG5 was highly expressed in AML cancer cell lines. Collectively, upregulation of lncRNA SNHG5 mediated by YY1, activates CTGF/VEGFA via targeting miR-26b to regulate angiogenesis of AML. Our work provides new insights into the molecular mechanisms of AML. Yes In vitro studies displayed that inhibition of SNHG5 with shRNA resulted in suppression of survival, cell cycle progression, migration/invasion of AML and capacity of adhesion and angiogenesis in human umbilical vein endothelial cells. 33318617 SNHG5 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell Interaction(UPF1/Wnt/β-catenin pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//EdU Staining//IF Through functional experiments, we determined that knockdown of SNHG5 repressed HCC cell proliferation and CSC-like properties, while over-expression of SNHG5 promoted cell growth. At the same time, CSC markers (CD44, CD133, and ALDH1) and related transcription factors (OCT4, SOX2, and NANOG) were downregulated when SNHG5 was knocked down. Mechanically, RNA immunoprecipitation (RIP) and RNA pulldown assay showed that SNHG5 regulated the proliferation and CSC-like properties of HCC by binding UPF1. Further investigations showed that expression of critical components of Wnt/β-catenin pathway (β-catenin, TCF4, c-myc, cyclinD1, and c-Jun) were upregulated with depletion of UPF1 in liver CSCs, which were downregulated with depletion of SNHG5. Yes Through functional experiments, we determined that knockdown of SNHG5 repressed HCC cell proliferation and CSC-like properties, while over-expression of SNHG5 promoted cell growth. At the same time, CSC markers (CD44, CD133, and ALDH1) and related transcription factors (OCT4, SOX2, and NANOG) were downregulated when SNHG5 was knocked down. Mechanically, RNA immunoprecipitation (RIP) and RNA pulldown assay showed that SNHG5 regulated the proliferation and CSC-like properties of HCC by binding UPF1. Further investigations showed that expression of critical components of Wnt/β-catenin pathway (β-catenin, TCF4, c-myc, cyclinD1, and c-Jun) were upregulated with depletion of UPF1 in liver CSCs, which were downregulated with depletion of SNHG5. 35338348 SNHG5 LncRNA Homo sapiens Acute Kidney Injury serum of patients with sepsis Interaction(miR-374a-3p/TLR4/NF-κB pathway) In Vivo Experiment//Western Blot//Transfection//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//ELISA Here, we found a significant increase in the expression of lncRNA small nuclear RNA host gene 5 (SNHG5) in the serum of patients with sepsis than healthy controls. Similar results were obtained from mouse model of sepsis. Mechanistically, we showed that SNHG5 can combine with microRNA-374a-3p (miR-374a-3p), which inhibits nuclear factor-κB (NF-κB) activity by targeting TLR4. Yes Further investigations revealed that knockdown of SNHG5 improves the viability and reduces the rate of apoptosis and the generation of inflammatory cytokines in HK-2 and TCMK-1 cells treated with lipopolysaccharide. 33479745 SNHG5 LncRNA Homo sapiens diabetic macular edema atrial fluid and plasma Expression(lower expressed) CCK8//qRT-PCR//Western Blot SNHG5 expression was not only low in the atrial fluid and plasma in DME patients, but also lower in the refractory DME group compared to the idiopathic MH patients. SNHG5 expression in the aqueous humor and plasma was negatively correlated with disease duration, body mass index, and levels of fasting blood glucose, glycated hemoglobin, proteinuria, and glycosuria. Yes In the in vitro experiments, SNHG5 expression was significantly downregulated in high glucose-induced HMECs. After SNHG5 overexpression, cell proliferation, angiogenesis, and VEGF-A protein levels were distinctly downregulated. 35001073 Snhg5 LncRNA Rattus norvegicus Status Epilepticus microglia Regulation(nuclear factor-kappaB (NF-κB) signaling pathway) In Vivo Experiment//qRT-PCR//Transfection//Western Blot The results showed Snhg5 was up-regulated in the rat and microglia. Knockdown of Snhg5 inhibited LPS-induced inflammation and relative expression of p-65/p65, p-IκBα/IκBα. Moreover, down-regulation of Snhg5 attenuated SE-induced inflammation and reduced the number of microglia in hippocampus. These findings indicated that Snhg5 modulates the inflammation via nuclear factor-kappaB (NF-κB) signaling pathway in SE rats. Yes Knockdown of Snhg5 inhibited LPS-induced inflammation and relative expression of p-65/p65, p-IκBα/IκBα. 34980782 SNHG5 LncRNA Homo sapiens Glioma Glioma tissues Regulation[miR-205-5p/ZEB2 Axis] CCK8//qRT-PCR//Luciferase Report Assay//RIP Based on our findings, compared with normal tissues, the elevated expression of SNHG5 and decreased expression of miR-205-5p were observed in glioma tissues.With regard to the underlying mechanism, SNHG5 presented a direct inhibitory influence on miR-205-5p which targeted to the 3'-UTR region of zinc finger E-box binding homeobox 2 (ZEB2) mRNA. As a competing endogenous RNA (ceRNA), SNHG5 sponged miR-205-5p, regulating the expression of ZEB2 thereby. Yes The downregulation of SNHG5 exerted an obvious inhibitory effect on glioma cells in terms of their proliferation. 31920337 SNHG5 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow interaction[miR-489-3p,SOX4 ] RNA Pull-Down//CCK8//qRT-PCR//RIP//Flow Cytometry We first found that SNHG5 was up-regulated in both AML patient bone marrow samples and various AML cell lines. Our results demonstrated that SNHG5 affected the expression of SOX4 through binding miR-489-3p to regulate proliferation and apoptosis of AML, which might act as a prospective prognostic biological marker and a promising therapeutic target for AML. Yes Second, we found that knockdown of SNHG5 inhibited proliferation of AML cells and promoted apoptosis. 32266420 SNHG4 LncRNA Homo sapiens Stomach Neoplasms GC cells Interaction(miR-204-5p) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Transwell Assay . The results showed that SNHG4 expression in GC cells was at a higher level compared to normal gastric mucosal epithelial cells. Dual-luciferase reporter assay results showed that miR-204-5p was a direct target of SNHG4. Yes Knockdown of SNHG4 dramatically suppressed proliferation, migration and invasion, and blocked cell cycle progression of GC cells. Moreover, knockdown of SNHG4 upregulated microRNA-204-5p (miR-204-5p) expression, whereas downregulated ribonucleotide reductase subunit M2 (RRM2) expression in GC cells. Additionally, knockdown of SNHG4 suppressed GC tumorigenesis in xenograft mouse models. 33567852 SNHG6 LncRNA Homo sapiens Triple Negative Breast Neoplasms 47 breast specimens Epigenetics(splice variants(203)) Transfection//Wound Healing Assay//qRT-PCR//MTT//Cell Cycle Assay Among four splice variants of SNHG6 (202, 203, 204, and 207), SNHG6 203 was proved as an overexpressed splice variant in breast tumors. This transcript was expressed in HER2-negative breast tumors more frequently than in the positive ones. Moreover, the overexpression of SNHG6 203 led to lower migration ability of MCF7 cells and a non-significant reduction of their viability as HER2-negative breast cancer cells. Yes Overexpression of this variant in target cells resulted in cell cycle progression of MCF7 as HER2-negative cells. 36247503 SNHG6 LncRNA Homo sapiens ovarian clear cell carcinoma ovarian tissues Interaction[sponging miR-4465] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay In the present study, we showed via quantitative real-time PCR that SNHG6 expression was abnormally up-regulated in OCCC tissues relative to that in unpaired normal ovarian tissues. Moreover, SNHG6 functioned as a competing endogenous RNA (ceRNA), effectively acting as a sponge for miR-4465 and thereby modulating the expression of enhancer of zeste homolog 2 (EZH2). High SNHG6 expression was correlated with vascular invasion, distant metastasis and poor survival. Yes Further functional experiments demonstrated that knockdown of SNHG6 in OCCC cells inhibited cell proliferation, migration and invasion in vitro as well as tumour growth in vivo. 31119871 SNHG6 LncRNA Homo sapiens Carcinoma, Basosquamous WT tissues Interaction[targeting miR-15a] CCK8//Western Blot//Flow Cytometry//Transwell Assay In the results, overexpression of SNHG6 was found in WT tissues. In summary, SNHG6 is an oncogene of WT development by targeting miR-15a. Yes The knockdown of SNHG6 suppressed cell proliferation, migration and incursion, but promoted apoptosis. 31257923 SNHG6 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-485-3p/VPS45 axis] qRT-PCR In our study, the expression of SNHG6 was abnormally high in NSCLC tissues and cells.In conclusion, we proved that SPI1/SNHG6/miR-485-3p/VPS45 axis exerted oncogenic role in the cellular process of NSCLC cells. Yes Functionally, loss of SNHG6 expression led to the inhibition on the growth, migration and invasion of NSCLC cells. 32590190 SNHG6 LncRNA Homo sapiens gallbladder carcinoma serum regulation[ Hedgehog signaling pathway] Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay SNHG6 was highly expressed in gallbladder carcinoma, miR-26b-5p was downregulated, and the area under curve (AUC) of LncRNA SNHG6 and miR-26b-5p was more than 0.8. Inhibition of LncRNA SNHG6 expression can upregulate miR-26b-5p mediated Hedgehog signaling pathway, affect epithelial-mesenchymal transition, proliferation and invasion of cells, so LncRNA SNHG6is hoped to be a latent therapeutic target for gallbladder carcinoma. Yes Silencing of SNHG6 and upregulation of miR-26b-5p could promote cell apoptosis, inhibit cell growth, and epithelial-mesenchymal transition (ETM). 32744686 SNHG6 LncRNA Homo sapiens Colonic Neoplasms CRC tissues Regulation[Wnt/β-catenin signaling pathway] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay SNHG6 was over-expressed in CRC, and high expression of s SNHG6 were associated with short survival times. SNHG6 could regulate the progression of CRC via modulating the expression levels of miR-101-3p and the activity of Wnt/β-catenin signaling. Yes Moreover, silenced SNHG6 obviously inhibited CRC cell growth, weakened cell invasion capacity and blocked the Wnt/β-catenin signaling pathway. 31533634 SNHG6 LncRNA Homo sapiens Wilms Tumor Wilms' tumor cells Interaction(miR-429/ FRS2 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay The level of SNHG6 was elevated in Wilms' tumor tissues and cells, and SNHG6 played an oncogenic role to promote the proliferation and glycolysis and restrain the apoptosis of Wilms' tumor cells. MiR-429 was identified as a target of SNHG6, and miR-429 interference partly reversed the inhibitory effects induced by SNHG6 silencing on the malignant behaviors of Wilms' tumor cells. FRS2 mRNA bound to miR-429 in Wilms' tumor cells. SNHG6 upregulated the expression of FRS2 through acting as a sponge of miR-429. Yes The level of SNHG6 was elevated in Wilms' tumor tissues and cells, and SNHG6 played an oncogenic role to promote the proliferation and glycolysis and restrain the apoptosis of Wilms' tumor cells. 33481659 SNHG6 LncRNA Homo sapiens Chondrosarcoma chondrosarcoma tissues Expression [highly expressed] In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Colony Formation Assay//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//H&E Staining//IHC//Invasion Assay//ChIP Here we found that SNHG6 expression was upregulated and showed positive correlation with the progression of chondrosarcoma. Mechanistic study revealed that SNHG6 could recruit EZH2 and maintain high level of H3K27me3 to repress the transcription of tumor-suppressor genes, including KLF6. KLF6 was found to bind to the promoter region of SP1 and restrained its transcription, while SP1 could be recruited to the promoter region of SNHG6 and promoted its transcription to form a positive loop. Yes Functional assays demonstrated that SNHG6 was required for the proliferation, migration, and invasion of chondrosarcoma cells. 33431838 SNHG6 LncRNA Homo sapiens Amyotrophic Lateral Sclerosis 7 tumor and non-tumor tissues. Expression(highly expressed) qRT-PCR//Transfection//Cell Cycle Assay SNHG6 was more expressed in CRC tumors than non-tumor tissues. In tumor tissues, SNHG6 upregulation and tumors' grade progression were concurrent. SNHG6 was upregulated in cases with lymphovascular invasion than in cases with perineural invasion. Yes The knockdown of SNHG6 conduced to G1 arrest in CRC cells, more noticeably in high-grade ones. 35096086 SNHG6 LncRNA Homo sapiens Abortion, Spontaneous RSA patients and cell line Interaction(miR-101-3p/OTUD3 axis) Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay The results showed that SNHG6 and OTUD3 were up-regulated, and miR-101-3p was down-regulated in RSA patients. MiR-101-3p was a target of SNHG6, and OTUD3 was a target of miR-101-3p. There were negative correlations between the expression of miR-101-3p and OTUD3/SNHG6 in RSA patients. To sum up, silencing of SNHG6 enhanced the viability and migration, and inhibited the apoptosis of trophoblast cells through regulating miR-101-3p/OTUD3. SNHG6/miR-101-3p/OTUD3 may be potential targets for the prevention of unexplained RSA. Yes In addition, both SNHG6 silencing and miR-101-3p overexpression could increase cell viability and migration, decrease cell apoptosis, up-regulate Ki-67 and Bcl-2, and down-regulate Bax in HTR-8/SVneo cells. The effects of SNHG6 silencing on HTR-8/SVneo cells were reversed by miR-101-3p silencing or OTUD3 overexpression. 36173586 SNHG5 LncRNA Homo sapiens Osteosarcoma OS cells Regulation[miR-212-3p/SGK3 axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay In summary, our study demonstrated that lncRNA SNHG5 can regulate the proliferation and metastasis of OS cells through the miR-212-3p/SGK3 axis. This axis may provide a new target for future clinical treatment. Yes In this study, knockdown of lncRNA SNHG5 suppressed the growth and metastasis of OS cells, whereas the overexpression of SNHG5 produced an opposite result. 30250399 Snhg6 LncRNA Mus musculus Ischemic Stroke brain tissue,cell line Regulation[miR-181c-5p/BIM signalling ] qRT-PCR//Luciferase Report Assay//RIP//Western Blot The results show that SNHG6 expression was significantly increased both OGD-induced neuronal cells and MCAO model mice.This study revealed a novel function of SNHG6 in the modulating neuronal apoptosis in the ischaemic stroke model, and the role of SNHG6 in the regulating of neuronal apoptosis was at least partly via targeting miR-181c-5p/BIM signalling pathway. Yes Consistently, knockdown of SNHG6 reduced brain infarct size and improved neurological scores in the MCAO mice. 31334597 SNHG5 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[miR-154-5p/PCNA Axis] Western Blot//Flow Cytometry//FISH//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining Clinically, we observed an increased SNHG5 expression in breast cancer, whereas miR-154-5p was decreased in breast cancer tissues compared with the adjacent normal breast tissues. Taken together, our data uncover the SNHG5-miR-154-5p-PCNA axis and provide a novel mechanism to explain breast cancer proliferation. Yes SNHG5 promoted breast cancer proliferation and cell-cycle progression by upregulation of PCNA expression. 31255976 SNHG5 LncRNA Homo sapiens Breast Neoplasms CAFs Interaction(IGF2BP2/ZNF281 ) RNA Pull-Down//Western Blot//FISH//qRT-PCR//RIP//RNA-seq//Luciferase Report Assay//ELISA//IHC//ChIP LncSNHG5 was highly expressed in breast CAFs and played an essential role in premetastatic niche formation by promoting angiogenesis and vascular leakiness through regulation of ZNF281 in CAFs. lncSNHG5 enhanced ZNF281 mRNA stability by binding with the m6A reader IGF2BP2. Enhanced ZNF281 transcriptionally regulated CCL2 and CCL5 expression to activate P38 MAPK signaling in endothelial cells. High CCL2 and CCL5 expression was associated with tumor metastasis and poor prognosis in BC patients. Yes LncSNHG5 was highly expressed in breast CAFs and played an essential role in premetastatic niche formation by promoting angiogenesis and vascular leakiness through regulation of ZNF281 in CAFs. 36438499 SNHG5 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-181c-5p/CBX4 Axis) CCK8//qRT-PCR//Western Blot Low miR-181c-5p and high SNHG5 and CBX4 levels were found in NSCLC tissues and cells.Restoration of miR-181c-5p or knockdown of SNHG5 or CBX4 restrained NSCLC cell progression and inactivated the NF-κB pathway. Upregulated CBX4 abolished the effects of miR-181c-5p on reducing NSCLC cell progression. SNHG5 regulated the interaction between miR-181c-5p and CBX4. In vivo, restoration of miR-181c-5p or knockdown of SNHG5 or CBX4 retarded the tumor growth. Yes Restoration of miR-181c-5p or knockdown of SNHG5 or CBX4 restrained NSCLC cell progression and inactivated the NF-κB pathway. Upregulated CBX4 abolished the effects of miR-181c-5p on reducing NSCLC cell progression. SNHG5 regulated the interaction between miR-181c-5p and CBX4. In vivo, restoration of miR-181c-5p or knockdown of SNHG5 or CBX4 retarded the tumor growth. 35963709 SNHG5 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[miR-132-3p/CREB5] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Microarray//Transwell Assay SNHG5 or CREB5 was Expression[Expression[up-expression]-expression]-regulated in CRC tissues and cells, whereas miR-132-3p was Expression[down-expression]-regulated.The targeted relationship between miR-132-3p and SNHG5 or CREB5 was confirmed by dual luciferase report assay as well as RNA pull Expression[down-expression] assay. Yes Overexpression of SNHG5 and CREB5 resulted in the enhancement of proliferation, metastasis, migration and the inhibition of apoptosis in CRC cells, while miR-132-3p led to the opposite result. LncRNA SNHG5 promoted proliferation, migration and metastasis of CRC cells but inhibited apoptosis by modulating miR-132-3p/CERB5. 30395767 SNHG5 LncRNA Homo sapiens Osteoarthritis OA cartilage tissues Interaction(miR-10a-5p/H3F3B axis) Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay SNHG5 and H3F3B were downregulated, while miR-10a-5p was upregulated in OA cartilage tissues. Knockdown of SNHG5 enhanced IL-1β-induced apoptosis in chondrocytes. Rescue experiments verified that SNHG5 hindered apoptosis in IL-1β-stimulated chondrocytes by sponging miR-10a-5p. Moreover, H3F3B was a target of miR-10a-5p, and miR-10a-5p promoted IL-1β-induced chondrocyte apoptosis by regulating H3F3B. In addition, SNHG5 regulated H3F3B expression via sponging miR-10a-5p in IL-1β-treated chondrocytes. Yes Knockdown of SNHG5 enhanced IL-1β-induced apoptosis in chondrocytes. Rescue experiments verified that SNHG5 hindered apoptosis in IL-1β-stimulated chondrocytes by sponging miR-10a-5p. 32967481 SNHG5 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-363-3p/RNF38 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expression of SNHG5 and RNF38 was elevated in HCC tissues and cell lines, and highly expressed SNHG5 and RNF38 could induce apoptosis and repress proliferation, migration, as well as invasion in HCC cells. LncRNA SNHG5 may promote human HCC progression by regulating the miR-363-3p/RNF38 axis, providing a novel insight into the pathogenesis of HCC and therapeutic strategy for HCC treatment. Yes The expression of SNHG5 and RNF38 was elevated in HCC tissues and cell lines, and highly expressed SNHG5 and RNF38 could induce apoptosis and repress proliferation, migration, as well as invasion in HCC cells. 32329834 SNHG5 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues regulation[miR-655-3p/FZD4 axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The results showed that SNHG5 expression was upregulated in OSCC and promoted the viability, migration and invasion of OSCC cells. In conclusion, lncRNA SNHG5 promotes cell proliferation, migration and invasion in OSCC by regulating miR-655-3p/FZD4 axis. Yes Functionally, FZD4 promoted the progression of OSCC by interacting with the SNHG5/miR-655-3p axis. 33093919 SNHG4 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines interaction[sponging miR-204-5p] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay The results demonstrated that in GC tissues and cell lines.The findings of the current study revealed the potential mechanism of the SNHG4‑miR‑204‑5p pathway in GC, which may be conducive to the development of novel drugs against GC growth. SNHG4 was highly expressed Yes The downregulated expression of SNHG4 decreased the effects of miR‑204‑5p inhibitor on promoting cell proliferation, migration, invasion and epithelial‑mesenchymal transition, but enhanced the inhibitory effect of miR‑204‑5p on GC cell apoptosis. 33236157 SNHG6 LncRNA Homo sapiens Pituitary Neoplasms PA samples regulation[SNHG6/miR-994/RAB11A axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay SNHG6 was significantly upregulated in IPA samples, whereas miR-944 was downregulated. This study authenticates that the SNHG6/miR-994/RAB11A axis plays a crucial role in regulating proliferation, migration, invasion, and EMT of IPA cells. Yes SNHG6 markedly promoted viability, migration, invasion, and EMT of PA cells, whereas miR-944 transfection had the opposite effects. 32935999 SNHG3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[LncSNHG3/miR-139-5p/BMI1 axis] colony Formation Assay//qRT-PCR//MTT//Transwell Assay SNHG3 and BMI1 were upregulated in HCC, while miR-139-5p was downregulated. The lncRNA SNHG3/miR-139-5p/BMI1 axis plays an important role in cell proliferation, migration, and invasion in HCC. Yes Knockdown of SNHG3 or BMI1 and overexpression of miR-139-5p could inhibit cell proliferation, migration, and invasion in HCC. 31692508 SNHG3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Regulation[TGF-β pathway and IL-6/JAK2/STAT3 pathway] qRT-PCR In this study, we detected the upregulated expression of SNHG3 in NSCLC tissues as well as cells through quantitative reverse-transcription polymerase chain reaction (qRT-PCR) analysis.Our results suggested that E2F1 activated SNHG3 and promoted cell proliferation and migration in NSCLC via transforming growth factor-β pathway and interleukin-6/janus-activated kinase 2/signal transducer and activator of transcription 3 pathway, which implied that SNHG3 may be a biomarker for the treatment of patients with NSCLC. Using Kaplan-Meier analysis, we determined that a high-level of SNHG3 was associated with a low overall survival rate of patients with NSCLC. Yes Through gain and loss of function experiments, we demonstrated that SNHG3 had a significantly positive effect on NSCLC cell proliferation and migration. 31602642 SNHG3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung regulation[downregulating miR-340-5p] qRT-PCR//Western Blot Moreover, SNHG3 could bind with miR-340-5p and reduce its expression levels, and miR-340-5p attenuated SNHG3-induced tumor proliferation and HOXA10 expression in NSCLC cells. Our findings unveiled that SNHG3 might be an oncogenic factor in NSCLC by downregulating miR-340-5p. As a consequence, the elevated expression of SNHG3 and HOXA10 or lowered expression of miR-340-5p was related to the lymph node infiltration, distant metastases and unfavorable prognosis in NSCLC Yes Ectopic expression of SNHG3 boosted the proliferation and invasion of NSCLC cells in vitro and in vivo, whereas downregulation of SNHG3 reversed these effects. 33225676 SNHG3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-216a/ZEB1 Axis] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay We found highly upregulated SNHG3 in tissues and cells from NSCLC patients, which was linked to poor prognosis.Knockdown of SNHG3 inhibits NSCLC tumour development and progression by upregulation of ZEB1 and interference with miR-216a, revealing an attractive alternative target for patients with NSCLC. We found highly upregulated SNHG3 in tissues and cells from NSCLC patients, which was linked to poor prognosis. Yes SNHG3 silencing diminished the ability of NSCLC cells to proliferate, migrate, and invade and promoted apoptosis. 33177840 SNHG3 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-539/RUNX2 axis] Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay The expression of SNHG3 was significantly upregulated in CRC tissues compared to adjacent normal tissues, which was positively correlated with advanced clinical stage, distant metastasis and poor overall survival.Our works suggest that lncRNA SNHG3 promotes CRC growth and metastasis via regulating miR-539/RUNX2 axis, suggesting that the SNHG3 might be a potential therapeutic target for CRC. The expression of SNHG3 was significantly upregulated in CRC tissues compared to adjacent normal tissues, which was positively correlated with advanced clinical stage, distant metastasis and poor overall survival. Yes Functional experiments revealed that SNHG3 knockdown significantly decreased CRC growth and metastasis both in vitro and in vivo. 32187965 SNHG3 LncRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(miR-34b-5p/HuR/HOXC6 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP SNHG3 was highly expressed in CRC cells and CAFs-EVs, whereas CAFs-EVs facilitated CRC cell proliferation.Mechanically, CAFs-EVs carried SNHG3 into CRC cells to upregulate HuR expression by competitively binding to miR-34b-5p, promote the binding of HuR and HOXC6, and enhance HOXC6 transcription. miR-34b-5p over-expression or HOXC6 silencing annulled the effect of CAFs-EVs. SNHG3 carried by CAFs-EVs facilitated CRC proliferation via the miR-34b-5p/HuR/HOXC6 axis in vivo. Yes SNHG3 was highly expressed in CRC cells and CAFs-EVs, whereas CAFs-EVs facilitated CRC cell proliferation. 35922404 SNHG3 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines regulation[AKT/mTOR/ERK pathway] Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay Here, we discovered that lncRNA SNHG3 was significantly downregulated in PTC tissues and cell lines, the expression of SNHG3 was negatively correlated with the TNM stage and poor prognosis of PTC patients. Here, we discovered that lncRNA SNHG3 was significantly downregulated in PTC tissues and cell lines, the expression of SNHG3 was negatively correlated with the TNM stage and poor prognosis of PTC patients. Yes Functional studies illustrated that the depletion of SNHG3 via CRISPR/Cas9 technology promoted the proliferation, migration and invasion abilities of PTC cells. Tumor xenograft models confirmed the tumor-promoting role of silenced SNHG3 in vivo. 32284745 SNHG3 LncRNA Homo sapiens Osteoarthritis osteosarcoma tissues and cells Regulation[ SNHG3/miRNA-151a-3p/RAB22A axis] qRT-PCR//Western Blot SNHG3 and RAB22 A were highly expressed in osteosarcoma patients, while miRNA-151a-3p was lowly expressed. SNHG3 is highly expressed in osteosarcoma, and promotes the invasive and migratory potentials of osteosarcoma cells by absorbing miRNA-151a-3p to upregulate RAB22 A expression. The overall survival of osteosarcoma patients with high expression of SNHG3 was shorter than those with low expression. Yes SNHG3 overexpression markedly promoted invasive and migratory potentials of osteosarcoma cells. 30797154 SNHG3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[miR-326/SMAD3/ZEB1 signaling pathway] Western Blot//Tunel//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Transwell Assay In the present study, by analyzing 47 tissue specimens of human HCC, we found that the relative expression levels of SNHG3 were significantly higher in HCC tissues than those in the adjacent noncancerous tissues, whereas the relative expression levels of miR-326 were significantly lower in HCC tissues.In conclusion, we propose that SNHG3 promotes HCC progression via the miR-326/SMAD3/ZEB1 signaling pathway. The findings may provide novel targets for the diagnosis and treatment of HCC. Yes In the present study, by analyzing 47 tissue specimens of human HCC, we found that the relative expression levels of SNHG3 were significantly higher in HCC tissues than those in the adjacent noncancerous tissues, whereas the relative expression levels of miR-326 were significantly lower in HCC tissues. 31548493 hsa_circ_0087352 CircRNA Homo sapiens Aortic Aneurysm, Abdominal human AAA specimens Regulation(hsa-miR-149-5p) RNA Pull-Down//Western Blot//qRT-PCR//FISH//Luciferase Report Assay//ELISA//IHC First, we applied bioinformatics to analyze circRNA expression profile in human AAA specimens, and screened out hsa_circ_0087352, which is up-regulated in human AAA specimens and related to inflammatory response of THP-1 macrophages induced by LPS. Besides, hsa_circ_0087352 is stably expressed in THP-1 and mainly distributed in the nucleus. Then, we constructed ceRNA network of circRNA-miRNA-mRNA (IL-6/CCL2/NF-κB) in AAA and found that hsa_circ_0087352 promotes IL-6 transcription and the secretion of inflammatory cytokines by sponging endogenous hsa-miR-149-5p in macrophages. Dual luciferase reporter gene and RNA pull-down suggested hsa_circ_0087352 directly binds to hsa-miR-149-5p. Fluorescence in situ hybridization assay showed the localization of hsa_circ_0087352 and hsa-miR-149-5p in the nucleus of macrophages. Further, western blot demonstrated hsa_circ_0087352 expands the signal transduction of ERK/NF-κB pathway, then IκB phosphorylation promotes NF-κB p65 phosphorylation and nuclear translocation. In addition, hsa_circ_0087352 overexpression in macrophages induces human vascular smooth muscle cells (VSMC) apoptosis in macrophage-VSMC coculture system via the release of proapoptotic cytokines, such as IL-6, TNF-α and IL-1β. Overall, this study provides experimental evidence that hsa_circ_0087352 can be used as a new biomarker and therapeutic target for abdominal aortic aneurysm. Yes In addition, hsa_circ_0087352 overexpression in macrophages induces human vascular smooth muscle cells (VSMC) apoptosis in macrophage-VSMC coculture system via the release of proapoptotic cytokines, such as IL-6, TNF-α and IL-1β. 35286916 SNHG3 LncRNA Homo sapiens Breast Neoplasms BC tissues regulation[Notch signaling pathway] qRT-PCR//Luciferase Report Assay Highly expressed SNHG3 was observed in BC tissues. Our study demonstrated that interfered lncRNA SNHG3 promoted BC cell proliferation and metastasis by activating the Notch signaling pathway. Yes The growth of BC cells in vivo and in vitro was evidently repressed after silencing SNHG3. BC cell invasion and migration were inhibited by silencing SNHG3 in vitro. 32883233 SNHG3 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Expression[highly expressed] qRT-PCR//Western Blot The expression of SNHG3 was significantly up-regulated in ovarian cancer tissues compared with adjacent normal tissues. Higher SNHG3 expression levels positively associated with FIGO stage, lymph node metastasis, and poor prognosis of ovarian cancer patients. Yes Gain-of function and loss-of function assays demonstrated that SNHG3 knockdown inhibited ovarian cancer cell proliferation and invasion abilities. However, SNHG3 overexpression promoted ovarian cancer cell proliferation and invasion abilities. 29758922 SNHG3 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines regulation[miR-139-5p and Notch1] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay In OC tissues and cell lines, the expression of SNHG3 and Notch1 were significantly increased, and the expression of miR-139-5p was significantly decreased.In conclusion, SNHG3 could accelerate the proliferation and migration of OC cells by regulating miR-139-5p and Notch1. Yes Rescue experiments were performed to confirm whether SNHG3 could mediate OVCAR3 proliferation and migration through miR-139-5p and Notch1. 33552243 SNHG3 LncRNA Homo sapiens Ovarian Neoplasms OC tissues, serum, and cells regulation[Targeting miR-339-5p/TRPC3 Axis] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay SNHG3 was overexpressed in OC tissues, serum, and cells, and the overexpression in serum indicated a poor prognosis of patients.SNHG3 can be adopted as a marker for diagnosis and prognosis evaluation of OC and it plays a role in the progression of OC by enabling the miR-339-5p sponge to regulate TRPC3 expression. Yes It was also found that knockdown of SNHG3 could inhibit the malignant phenotypes of OC cells, cause G1/G0 cell cycle arrest, and intensify apoptosis. Furthermore, in in vitro experiments, the growth ability of OC cells was inhibited under knockdown of SNHG3. 33149611 SNHG3 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues regulation[miR-515-5p/GINS2 axis] qRT-PCR In our research, we first reported that lncRNA SNHG3 was up-regulated in bladder cancer tissues and positively related to poor clinical prognosis. Moreover, SNHG3 positively regulated GINS2 expression by sponging miR-515-5p under a competing endogenous RNA (ceRNA) mechanism. In our research, we first reported that lncRNA SNHG3 was up-regulated in bladder cancer tissues and positively related to poor clinical prognosis. Yes Moreover, knockdown of lncRNA SNHG3 significantly suppressed the proliferation, migration, invasion and EMT process of Bca cells in vitro and vivo. 32596993 SNHG3 LncRNA Homo sapiens Urinary Bladder Neoplasms BLCa specimens and cells Interaction(SNHG3/c-MYC/BMI1 axis) qRT-PCR//IHC Herein, we verified that lncRNA SNHG3 is upregulated in human BLCa specimens and is proportional to poor clinical prognosis via a combination of bioinformatic analyses and wet bench experiments. Next, RNA sequencing, bioinformatics analyses and western blots indicated that SNHG3 could promote c-MYC expression. RNA immunoprecipitation, actinomycin D assay and western blot assays suggested that SNHG3 could also bind c-MYC protein which subsequently facilitate the stabilization of BMI1 mRNA, thus enhancing BMI1 protein level. Herein, we verified that lncRNA SNHG3 is upregulated in human BLCa specimens and is proportional to poor clinical prognosis via a combination of bioinformatic analyses and wet bench experiments. Yes In vitro assays including CCK-8, EdU, colony formation, wound healing, transwell, and tube formation demonstrated that SNHG3 knockdown and overexpression potently inhibited and enhanced BLCa cell proliferation, migration, invasion, and angiogenesis. In addition, IVIS imaging revealed that SNHG3 knockdown could significantly inhibit M-NSG mice xenograft tumor growth. 36208024 SNHG3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cell lines Regulation[NFYC ,Wnt/β-catenin pathway ] qRT-PCR//RNA Pull-Down//RIP It was revealed that the expression level of SNHG3 was remarkably elevated in OSCC cell lines compared with the nontumor cell line.At last, it was confirmed by rescue experiments that the inhibiting impacts of SNHG3 knockdown on OSCC cell proliferation and migration could be partly revived by NFYC overexpression. Besides, we validated that Wnt/β-catenin pathway was also involved in SNHG3-regulated OSCC progression. Yes It was demonstrated by functional experiments that SNHG3 knockdown notably inhibited cell proliferation and migration in OSCC. 31762107 SNHG3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Interaction(miR-2682-5p/HOXB8 ) CCK8//qRT-PCR HOXB8 was markedly upregulated in OSCC tissues and cell lines. Furthermore, cell proliferation and migration were inhibited due to the shortage of HOXB8. HOXB8 was targeted by miR-2682-5p that negatively regulated cell proliferation and migration. Small nucleolar RNA host gene 3 (SNHG3) acted as a sponge for miR-2682-5p. Inhibition of miR-2682-5p or the overexpression of HOXB8 rescued the effects of SNHG3 silencing on the proliferation and migration. Yes HOXB8 was markedly upregulated in OSCC tissues and cell lines. Furthermore, cell proliferation and migration were inhibited due to the shortage of HOXB8. HOXB8 was targeted by miR-2682-5p that negatively regulated cell proliferation and migration. Small nucleolar RNA host gene 3 (SNHG3) acted as a sponge for miR-2682-5p. Inhibition of miR-2682-5p or the overexpression of HOXB8 rescued the effects of SNHG3 silencing on the proliferation and migration. 32989886 SNHG3 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(miR-186-5p/ZEB1 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//IHC//Transwell Assay We demonstrated that the expression of SNHG3 was abnormally high in breast cancer tissues and cells, and transgenic expression of SNHG3 promoted the proliferation, migration, and invasion of breast cancer cell lines (MCF-7 and MDA-MB-231). Moreover, the expression of zinc finger E-box binding homeobox 1 (ZEB1) increased after SNHG3 overexpression and vice versa. Overexpression of ZEB1 triggered cellular migration and invasion behaviors. Analysis of the mechanism underlying these effects suggested that SNHG3 is an effective sink for miR-186-5p and modulates ZEB1 repression, conferring an additional level to its post-transcriptional regulation. Yes We demonstrated that the expression of SNHG3 was abnormally high in breast cancer tissues and cells, and transgenic expression of SNHG3 promoted the proliferation, migration, and invasion of breast cancer cell lines (MCF-7 and MDA-MB-231). The mean volume of the xenografts from the SNHG3-knockdown MCF-7 cells was lower than that of the control tumor cells. 33594311 SNHG3 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[miR-384/HDGF axis] Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay In this study, we found that SNHG3 was upregulated and associated with tumour malignancy in patients with breast cancer.The findings of this study show that SNHG3 functions as an oncogene in breast cancer and promotes breast cancer cell proliferation and invasion by regulating the miR-384/HDGF axis. Yes SNHG3 knockdown inhibited the growth and metastatic capabilities of breast cancer cells in vitro and vivo. 31586299 SNHG4 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues interaction[SNHG4/microRNA-let-7e/KDM3A/p21 pathway ] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay lncRNAs SNHG4 and KDM3A were both upregulated in NSCLC tissues. Taken together, the key findings of the current study demonstrate a novel lncRNA SNHG4/let-7e/KDM3A/p21 axis in NSCLC, highlighting a promising therapeutic target for NSCLC. Yes The knockdown of lncRNA SNHG4 or KDM3A inhibited H1299 cell viability, colony formation, invasion, migration, and cycle progression while inducing apoptosis. 33816782 SNHG4 LncRNA Homo sapiens Osteosarcoma osteosarcoma samples and cell lines interaction[miR-224-3p] qRT-PCR//MTT//Colony Formation Assay//RIP The expression level of lncRNA SNHG4 was significantly elevated in osteosarcoma samples and cell lines as compared with the adjacent normal tissues, and SNHG4 high expression was associated with tumour size (TS) and poor prognosis in patients with osteosarcoma. Our findings demonstrated that LncRNA SNHG4 promoted tumour growth by sponging miR-224-3p and represented a poor prognostic factor in patients with osteosarcoma. The expression level of lncRNA SNHG4 was significantly elevated in osteosarcoma samples and cell lines as compared with the adjacent normal tissues, and SNHG4 high expression was associated with tumour size (TS) and poor prognosis in patients with osteosarcoma. Yes Knockdown of SNHG4 suppressed cell viability and invasive potential, whereas ectopic SNHG4 expression displayed the opposite effects. 30152090 SNHG4 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung serum samples, tissues and cell line(BEAS-2B) Expression [highly expressed] qRT-PCR LncRNA SNHG4 level was significantly more elevated in non-small cell lung cancer serum samples and tissues than in healthy controls Yes After transfection with the SNHG4 silencing plasmid, A549 cell viability was significantly inhibited, while apoptosis was promoted. 34686507 SNHG4 LncRNA Homo sapiens Lung Neoplasms cell lines Interaction[regulating miR-98-5p] Western Blot//Wound Healing Assay//qRT-PCR//IF//MTT//Luciferase Report Assay//Cell Cycle Assay//Transwell Assay We examined the expression of SNHG4 in three human squamous carcinoma cell lines and three human adenocarcinoma cell lines, among which NCI-H1437 and SK-MES-1 showed higher SNHG4 levels (Fig. 1A). SNHG4 probably exerts its pro-survival and pro-metastatic effects by sponging anti-tumor miR-98-5p. Yes We observed significantly inhibited cell proliferation in vitro and reduced tumor growth in vivo after SNHG4 silencing. SNHG4 knockdown also led to cell cycle arrest at the G1 phase, accompanied with down-regulation of cyclin-dependent kinases CDK4 and CDK6. 31220419 SNHG4 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue samples and cells Interaction(miR-590-3p/CDK1 axis) CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The expression of CDK1 was considerably increased in CRC tissue samples and cells and had a positive correlation with the expression of SNHG4 in CRC. miR-590-3p simultaneously bound to SNHG4 and CDK1. miR-590-3p functioned to inhibit CDK1 expression. Yes SNHG4 silencing not only caused S phase cell cycle arrest but also significantly downregulated the CDK1, cyclin B1, and cyclin A2 protein levels in CRC cells. 33744866 SNHG4 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-144-3p/MET axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay LncRNA SNHG4 sponges miR-144-3p and upregulates MET to promote the proliferation, colony formation, invasion, and immune escape of CRC cells, leading to the progression of CRC. Yes Knockdown of lncRNA SNHG4 suppressed the proliferation, colony formation and invasion of CRC cells (all P<0.05). 34786048 SNHG4 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(RNF14/ Wnt/β-catenin signal) RNA Pull-Down//Western Blot//qRT-PCR//RIP//FISH//IHC//IF SNHG4, TAF15 and RNF14 were up-regulated in CRC tissues. The inhibited malignant phenotypes caused by SNHG4 knockdown were impeded by TAF15 or RNF14 overexpression. Mechanistically, SNHG4 recruited TAF15 protein and thus promoted the interaction between TAF15 protein and RNF14 mRNA, leading to the increased RNF14 mRNA stability. Yes SNHG4 overexpression promoted cell proliferation, migration, invasion, and Wnt/β-catenin pathway activation in vitro, as well as tumor growth in vivo. 36482019 SNHG4 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissue samples and cell lines regulation[SNHG4/miR-204-5p/RUNX2 axis] qRT-PCR//Luciferase Report Assay SNHG4 was highly expressed in RCC tissue samples and cell lines.SNHG4 and miR-204-5p might be indicated in RCC progression via RUNX2, suggesting the potential use of SNHG4/miR-204-5p/RUNX2 axis in RCC treatment. SNHG4 was highly expressed in RCC tissue samples and cell lines, and its upregulation was significantly involved in node involvement, distant metastasis, and reduced overall and relapse-free survival of patients with RCC. Yes SNHG4 acted as an oncogenic lncRNA with promoted RCC cell proliferation, migration, invasion, and inhibited apoptosis. SNHG4 boosted tumor growth in xenograft mouse models. 33088220 SNHG4 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-211-5p/CREB5 axis) qRT-PCR Our findings demonstrated that the data from The Cancer Genome Atlas (TCGA) displayed that the higher expression of lncRNA SNHG4 was detected in HCC tissues, which predicted the poor prognosis. A series of follow-up studies have shown that SNHG4 promoted the progression and malignancy of HCC through upregulating CREB5 via sponging miR-211-5p. Our findings demonstrated that the data from The Cancer Genome Atlas (TCGA) displayed that the higher expression of lncRNA SNHG4 was detected in HCC tissues, which predicted the poor prognosis. The upregulation of SNHG4 was positively associated with worse clinicopathological characteristics. Yes We found that SNHG4 enhanced the proliferative, migratory and invasive capacities of HCC cell line, and facilitated the tumor growth in vivo. 36565037 SNHG4 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines interaction[sponging miR-377-3p] CCK8//qRT-PCR//Flow Cytometry//EdU Staining//Transwell Assay In our study, we found that lncRNA SNHG4 was highly expressed in osteosarcoma tissues and cell lines. Taken together, SNHG4 promotes cell proliferation and migration by sponging miR-377-3p in osteosarcoma. Additionally, the SNHG4 expression was related to distant metastasis, TNM stage, and survival of osteosarcoma patients. Yes Through SNHG4 knockdown, the proliferation of osteosarcoma cells was considerably restrained and the cell apoptosis was induced in vivo and in vitro. 32537941 SNHG3 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-448/DNMT1) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that SNHG3 was upregulated in gastric cancer and that SNHG3 knockdown or miR-448 overexpression inhibited SEP9 methylation and therefore increased its expression, thereby inhibiting the growth, metastasis, and spread of gastric cancer cells. Yes We found that SNHG3 was upregulated in gastric cancer and that SNHG3 knockdown or miR-448 overexpression inhibited SEP9 methylation and therefore increased its expression, thereby inhibiting the growth, metastasis, and spread of gastric cancer cells. 35528235 SNHG4 LncRNA Homo sapiens Leukemia, Myeloid, Acute Bone marrow regulation[miR-10a/PTEN ] CCK8//qRT-PCR//Western Blot In this study, we found that SNHG4 was downregulated in AML patients compared to healthy participants. In conclusion, SNHG4 may regulate miR-10a/PTEN to inhibit the proliferation of AML cells. Yes Cell proliferation analysis showed that SNHG4 and PTEN overexpression led to decreased proliferation rates of AML cells and attenuated the enhancing effects of miR-10a on cell proliferation. 32319862 SNHG4 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and adjacent normal cervical tissues,cell lines(NCEC,c4-1, Caski, HeLa, SiHa) Interaction[targeting miR-148a-3p] qRT-PCR//Luciferase Report Assay//RIP//Western Blot The SNHG4 expression in CC tissues was remarkably up-regulated, compared with the adjacent normal tissues.Compared with normal cells, the expression of SNHG4 in CC cell lines was markedly up-regulated.In conclusion, SNHG4 could be used as a competitive endogenous RNA to bind to miR-148a-3p, thereby up-regulating the expression of c-Met and ultimately promoting the progression of CC, which provided a potential therapeutic target for the targeted treatment of CC. Yes Finally, in vivo experiments confirmed that silence SNHG4 down-regulated the expression of c-Met by promoting miR-148a-3p, and ultimately suppressed the growth of CC tumor in vivo. 31590627 SNHG4 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC cell and tissues Interaction(miR-25/FBXW7 Axis ) Cell Proliferation Assay//qRT-PCR SNHG4 was downregulated in PTC tissues compared with the adjacent normal tissues of PTC patients. SNHG4 sponged with miR-25, while SNHG4 and miR-25 overexpression failed to alter each other. SNHG4 overexpression resulted in upregulated FBXW7, which is a targeted of miR-25. miR-25 overexpression increased PTC cell proliferation. Overexpression of SNHG4 and FBXW7 played an opposite role and abolished the effect of miR-25 overexpression. Yes G4 may interact with the miR-25/FBXW7 axis to suppress PTC cell proliferation. 36004691 SNHG4 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues,cell lines Interaction[miR-377] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay SNHG4 was highly expressed in PCa and its upregulation was induced by transcription factor SP1. In addition, miR-377 was a target of SNHG4 and ZIC5 was a target gene of miR-377 in PCa. SNHG4 promoted ZIC5-mediated growth and metastasis through modulating miR-377. The high levels of SNHG4 were distinctly associated with tumor stage, lymph node metastasis, and reduced overall survival of patients with PCa. Yes SNHG4 knockdown inhibited the growth, migration, and invasion of PCa cells. 31608997 SNHG4 LncRNA Homo sapiens Neuroblastoma neuroblastoma tissues and cell lines interaction[sponging miR-377-3p] Wound Healing Assay//CCK8//qRT-PCR//Cell Apoptosis Assay//Cell Cycle Assay//EdU Staining It was discovered that lncRNA SNHG4 exhibited high expression in neuroblastoma tissues and cell lines, and the expression of SNHG4 was associated with the survival of neuroblastoma patients.Collectively, we revealed the functions of SNHG4 and miR-377-3p in neuroblastoma. It was discovered that lncRNA SNHG4 exhibited high expression in neuroblastoma tissues and cell lines, and the expression of SNHG4 was associated with the survival of neuroblastoma patients. Yes Additionally, SNHG4 decrement markedly repressed neuroblastoma cells to proliferate and stimulate their apoptosis in vivo and in vitro. 32614236 SNHG3 LncRNA Homo sapiens Stomach Neoplasms cell lines( GES-1,MGC-803, AGS, BGC-823, SGC-7901, MKN-45,HGC-27 ) Interaction[regulated MED18] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//ChIP We first observed significant overexpression of SNHG3 in cancer cell lines were observed in our cell panel including MGC-803, AGS, BGC-823, SGC-7901, MKN-45, N87 and HGC-27 (Fig. ​(Fig.1a).1a).Our data unraveled the oncogenic properties of high SNHG3 in GC, which predominantly depended on epigenetically regulated MED18. Our data suggested that high SNHG3 associated with unfavorable prognosis in respect to overall and metastasis-free survival. Yes SNHG3-deficiency significantly suppressed cell proliferation and cell viability in vitro and xenograft progression in vivo. 31534128 SNHG3 LncRNA Homo sapiens Stomach Neoplasms GC cell lines and tissues Interaction( miR-139-5p/MYB axis) In Vivo Experiment//IHC//Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay We found that SNHG3 expression in GC cell lines and tissues was significantly increased, and the upregulation of this lncRNA was correlated with tumor clinical stage and decreased patient survival. Mechanistically, SNHG3 was found to bind and sequester miR-139-5p, thereby indirectly promoting the upregulation of the miR-139-5p target gene MYB. We found that SNHG3 expression in GC cell lines and tissues was significantly increased, and the upregulation of this lncRNA was correlated with tumor clinical stage and decreased patient survival. Yes Knocking down SNHG3 in GC cells impaired the proliferative, migratory, and invasive activity in vitro and constrained in vivo GC xenograft tumor growth. 34898477 SNHG3 LncRNA Homo sapiens Stomach Neoplasms GC cell lines Interaction(miR-326/TWIST axis) Western Blot//CCK8//RIP//qRT-PCR//Luciferase Report Assay//Transwell Assay The results showed that lncRNA SNHG3 and TWIST were highly expressed in GC cell lines, while miR-326 was expressed to a low degree.In conclusion, lncRNA SNHG3 may promote GC progression through the miR-326/TWIST axis, which may provide a new diagnostic and prognostic biomarker for GC. Yes Moreover, lncRNA SNHG3 knockdown or miR-326 overexpression significantly inhibited cell proliferation, migration, and invasion of GC cell lines. 34257656 SNHG6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cell lines Interaction(miR-101-3p/EZH2 pathway) Western Blot//Transfection//Wound Healing Assay//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay In this study, we verified the tumour-promoting effect of SNHG6 through sponging miR-101-3p, and their levels were negatively correlated in human samples of OSCC. Moreover, we confirmed that SNHG6/miR-101-3p affects OSCC by regulating the expression of the enhancer of zeste 2 (EZH2). The effect of EZH2 silencing resembled closely that of SNHG6 knockdown. Yes In this study, we verified the tumour-promoting effect of SNHG6 through sponging miR-101-3p, and their levels were negatively correlated in human samples of OSCC. Moreover, we confirmed that SNHG6/miR-101-3p affects OSCC by regulating the expression of the enhancer of zeste 2 (EZH2). The effect of EZH2 silencing resembled closely that of SNHG6 knockdown. 34766670 SNHG6 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Interaction(YBX1) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay Quantitative real-time PCR was then used to demonstrate the expression of SNHG6 in ccRCC tissues. SNHG6 overexpression is highly associated with malignant features in patients and is a prognostic indicator. Mechanistic investigations identified that SNHG6 exerts oncogenic effects by interacting with YBX1, and then, enhancing HIF1α translation. SNHG6 overexpression is highly associated with malignant features in patients and is a prognostic indicator. Yes SNHG6 significantly promotes ccRCC cell proliferation and metastasis in vitro and in vivo. 33150667 SNHG8 LncRNA Homo sapiens Esophageal Neoplasms tumor tissues or cells Interaction(miR-1270/BACH1 axis) qRT-PCR//IHC//Western Blot The results indicated that lncRNA SNHG8 should be a cancer-promoting factor with a relatively high expression level in esophageal cancer. In addition, based on the results of the binding site analysis and the luciferase reporter system, SNHG8 functions by the miR-1270/BACH1 axis. The follow-up experiments verified that lncRNA SNHG8 could down-regulate the expression of miR-1270 to increase the BACH1 expression. Yes Moreover, knockdown SNHG8 inhibited the cell viability and induced cell apoptosis in KYSE30 and TE-1 cells. 35067159 SNHG7 LncRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-342-3p/AKT2 axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay SNHG7 expressions in glioma tissues and cells were increased, upregulation of SNHG7 promotes cell viability, invasion and migration. SNHG7 was shown to bind with miR-342-3p, and upregulating SNHG7 reduced miR-342-3p expression. AKT2 was the target gene of miR-342-3p, and miR-342-3p expression was decreased while AKT2 expression was increased in glioma tissues. Yes SNHG7 expressions in glioma tissues and cells were increased, upregulation of SNHG7 promotes cell viability, invasion and migration. High expression of miR-342-3p inhibited cell viability, invasion and migration and reduced AKT2 expression, whereas low expression of miR-342-3p did the opposite effect. 32628059 SNHG7 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cell lines Regulation[Wnt/β-catenin pathway] Western Blot//qRT-PCR//MTT//Cell Cycle Assay//Colony Formation Assay//Transwell Assay In this study, we discovered that the expression levels of SNHG7 were significantly increased in bladder cancer tissues and cell lines.Collectively, SNHG7 elicited carcinogenic functions in bladder cancer partially via activating Wnt/β-catenin signaling pathway, suggesting a potential target for the treatment and prognosis of bladder cancer. Patients with high expression level of SNHG7 suffered from poor prognosis. Yes Additionally, knockdown of SNHG7 induced declined cell viability, proliferation as well as G0/G1 cell cycle arrest. Furthermore, we found that cell migratory ability was markedly reduced after silencing SNHG7. 30527358 SNHG7 LncRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cells regulation[ELK1/lncRNA-SNHG7/miR-2682-5p feedback loop] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay SNHG7 was conspicuously highly expressed in BCa tissues and cells.ELK1/SNHG7/miR-2682-5p feedback loop enhances cell growth, migration and invasion in BCa. The upregulated expression of SNHG7 was related with poor prognosis in BCa patients. Yes Moreover, SNHG7 exerted oncogenic functions in BCa through enhancing cell growth, migration and invasion. 32898531 SNHG7 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Interaction[binding to DNMT1] Western Blot//Flow Cytometry//qRT-PCR//RIP//ChIP QRT-PCR results demonstrated that the expression of SNHG7 in osteosarcoma tissues was remarkably higher than that in paracancerous tissues.Highly expressed SNHG7 can promote the proliferation and inhibit apoptosis of osteosarcoma cells by regulating p53 expression by binding to DNMT1. Yes The inhibition of SNHG7 in osteosarcoma cells U2OS and HOS promoted cell proliferation, arrested cell cycle in the G0/G1 phase and induced apoptosis. 31114984 SNHG7 LncRNA Homo sapiens Parkinson Disease PD patients Interaction(miR-425-5p/TRAF5/NF-κB axis) qRT-PCR//MTT//RIP In comparison to healthy donors, SNHG7 was found upregulated while miR-425-5p expression was downregulated in PD patients. Mechanistically, SNHG7 served as a competitive endogenous RNA by sponging miR-425-5p and promoted TRAF5 mediated inflammation and oxidative stress. Inhibition of SNHG7 ameliorated neuronal apoptosis in PD through relieving miR-425-5p/TRAF5/NF-κB signaling pathway modulated inflammation and oxidative stress, and similar results were observed in the Rot-mediated rat model of PD. Yes Functional experiments confirmed that SNHG7 downregulation or miR-425-5p overexpression attenuated neuronal apoptosis in the Rot-mediated PD model, TH-positive cell loss, and microglial activation by mitigating inflammation and oxidative stress. 34369042 SNHG7 LncRNA Homo sapiens Esophageal Neoplasms ESCC tumor tissues and ESCC cell lines Interaction(miR-625) Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Compared to that in adjacent normal tissues and HET1A cell lines, the expression level of SNHG7 in ESCC tumor tissues and ESCC cell lines was up-regulated, while the expression level of miR-625 was down-regulated. Yes ESCC cell proliferation, migration, and invasion were significantly promoted by SNHG7 overexpression but inhibited by silencing of SNHG7. Further, luciferase reporter gene experiments confirmed that SNHG7 interacted with miR-625, and rescue experiments showed that SNHG7 promoted the malignant phenotype by inhibiting miR-625. 34012636 SNHG7 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay LncRNA SNHG7 expression increased significantly in cervical cancer tissues. In addition, the survival time of patients with high expression of lncRNA SNHG7 was remarkably shortened. Yes The inhibition of lncRNA SNHG7 expression markedly inhibited cervical cell proliferation and invasion. 31773679 SNHG7 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines regulation[miR-485-5p/JUND axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IP//Transwell Assay We found that SNHG7 was markedly enhanced in CC tissues and cell lines, and associated with poor clinical characteristics.SNHG7 promoted CC progression through miR-485-5p/JUND axis. Yes In vitro, knockdown of SNHG7 inhibited CC cell proliferation, migration and invasion, as well as aggravated cell apoptosis. 32161467 SNHG7 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-138-5p to regulate EZH2 expression) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis The results revealed that SNHG7 expression was upregulated in glioma tissues and cell lines, while microRNA (miR)-138-5p expression was downregulated. Mechanistic studies demonstrated that SNHG7 downregulated miR-138-5p expression, which subsequently affected the expression levels of its target gene, enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2). Yes Moreover, the knockdown of SNHG7 expression decreased the proliferation of glioma cells. 34113393 SNHG7 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer cell line SKOV3/PTX and heyA8-PTX cells Interaction(EIF4G2) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Transwell Assay RNA immunoprecipitation assay was performed to analyze the interaction of lncRNA SNHG7 and EIF4G2. Overexpression of EIF4G2 by transfection with Ov- EIF4G2 plasmids efficiently blocked the changes of migration and invasion, as well as G0/1 arrest caused by lncRNA SNHG7 silencing. Yes The experiment results of wound healing and transwell showed that in paclitaxel-resistant ovarian cancer cells, transfection with siRNA-SNHG7 in ovarian cancer cells reduced cell migration and invasion.  34709112 SNHG7 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC cells regulation[miR-514a-5p/ELAVL1 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining SNHG7 was upregulated in NPC cells, and absence of SNHG7 suppressed cell proliferation as well as promoted cell apoptosis in NPC. LncRNA SNHG7 promotes the proliferation and migration of nasopharyngeal carcinoma by miR-514a-5p/ ELAVL1 axis. Yes In the end, rescue assays demonstrated that the miR-514a-5p deficiency restored the NPC progression inhibited by SNHG7 silence, and ELAVL1 partly counteracted the restoration caused by miR-514a-5p inhibitor in HNE1 cells. 32370736 SNHG7 LncRNA Homo sapiens Thyroid Neoplasms TC cells and tissue Interaction[downregulating BDNF] Western Blot//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay SNHG7 expression level was higher in TC samples than that in corresponding ones.These results suggested that knockdown of SNHG7 could inhibit TC cell proliferation and induce cell apoptosis via downregulating BDNF, which might be a potential therapeutic target in TC. The SNHG7 expression was associated with tumor size and TNM stage. Yes Moreover, TC cell proliferation was inhibited, and TC cell apoptosis was induced after SNHG7 was knocked down in vitro. 31210313 SNHG7 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues,cell lines Regulation[miR-342-3p/ID4 axis] qRT-PCR We found that SNHG7 was overexpressed in both PC tissues and cell lines.Moreover, SNHG7 was found to regulate the expression of ID4 via sponging miR-342-3p. Additionally, this finding was supported by in vivo experiments. High expression level of SNHG7 was correlated with the poor prognosis. Yes SNHG7 knockdown inhibited the proliferation, migration and invasion of PC cells. 30949340 SNHG7 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells Interaction( miR-146b-5p/Robo1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay The results indicated that SNHG7 was highly expressed in PC tissues and cells. It was also found that SNHG7 was sponged by miR-146b-5p and that Robo1 was a target of miR-146b-5p. Yes Moreover, it was demonstrated that SNHG7 knockdown inhibited cell proliferation, migration and invasion, as well as tumorigenesis and apoptosis of PC cells in vitro and in vivo by regulating miR-146b-5p. 33680120 SNHG7 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues regulation[ lncRNA-SNHG7/miRNA-181/cbx7 ] qRT-PCR SNHG7 was found to be down-regulated in LUAD tissues compared with normal tissues. Taken together, loss of SNHG7 in LUAD up-regulated mir-181 and then down-regulated the tumor suppressor cbx7. Yes Altered SNHG7 expression induced changes in cell proliferation and migration both in vitro and in vivo. 32201260 SNHG7 LncRNA Homo sapiens Prostatic Neoplasms Regulation[miR-324-3p/WNT2B axis] Western Blot//qPCR//MTT//Colony Formation Assay//Transwell Assay In this study, We found a lncRNA SNHG7 was overexpressed in PCa cell lines and tissues. Yes LncRNA SNHG7 promotes prostate cancer migration and invasion by modulating EMT. Further study indicated that lncRNA SNHG7 acts as a sponge for miRNA-324-3p and positively regulates WNT2B by a sponge effect. Moreover, We confirmed that WNT2B, an important protein in the Wnt signal pathway, promotes the malignant phenotype of PCa cells and mediated the biological effects exerted by lncRNA SNHG7. Overall, our study suggested that lncRNA SNHG7 could promote PCa EMT via miR-324-3p and WNT2B in vitro. The lncRNA SNHG7/miR-324-3p /WNT2B axis regulatory network might provide a potential new therapeutic strategy for PCa treatment. 31324390 SNHG7 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(SRSF1/c-Myc axis) CCK8//qRT-PCR//Western Blot SNHG7 and c-Myc were highly expressed in PCa tissues and cells. Mechanistically, SNHG7 regulated c-Myc via interacting with SRSF1. Gain- and loss-of function experiments revealed that SNHG7 promoted glycolysis via SRSF1/c-Myc axis in PC-3 and DU-145 cells. Yes Methyltransferase-like 3 (METTL3)-mediated m6A modification of SNHG7 and enhanced its stability. Silencing of SNHG7 suppressed proliferation and glycolysis in PCa cells. 35405116 SNHG7 LncRNA Homo sapiens Melanoma malignant melanoma tissues and cell lines regulation[miR-9] qRT-PCR The present study showed an increase of SNHG7 expression in malignant melanoma tissues and cell lines.Bioinformatics analysis demonstrated that SNHG7 functions as a molecular sponge for miR-9 in biological behavior of melanoma cells. Yes Besides, SNHG7 knockdown inhibited proliferation and migration in malignant melanoma cells. In addition, SNHG7 knockdown decreased xenograft growth in vivo. 32365219 SNHG7 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer and paired adjacent normal tissues Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay lncRNA SNHG7 was overexpressed in bladder cancer tissues compared to paired normal tissues and expression of SNHG7 was higher in high-grade than low-grade tumors. The malignant phenotypes were significantly inhibited when we inhibited expression of lncRNA SNHG7 in several bladder cell lines. Yes The malignant phenotypes were significantly inhibited when we inhibited expression of lncRNA SNHG7 in several bladder cell lines. 30719150 SNHG7 LncRNA Homo sapiens Ovarian Neoplasms ovarian tumour tissues interaction[EZH2 ] RIP//qRT-PCR//EdU Staining//Transwell Assay We discovered that in the context of OC there is a significant up-regulation of the lncRNA SNHG7. In summary, this research demonstrates that lncRNA SNHG7 is an SP1-activated molecule that contributes to OC progression by providing a scaffold whereby EZH2 can repress KLF2 expression. Yes Knocking down this lncRNA disrupted both OC cell invasion and proliferation, while its overexpression had the opposite effect. 32420685 SNHG7 LncRNA Homo sapiens Pituitary Neoplasms tissues and cells Interaction(miR-449a axis) In Vivo Experiment//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//IHC//Transwell Assay We identified the aberrant up-regulation of SNHG7 in pituitary adenoma both in vivo and in vitro, which associated with poor survival outcome.We further predicted and validated that SNHG7 negatively regulated miR-449a via sponging. Concurrent inhibition of miR-449a restored cell viability, apoptosis, migration and invasion influenced by SNHG7-deficiency. We identified the aberrant up-regulation of SNHG7 in pituitary adenoma both in vivo and in vitro, which associated with poor survival outcome. Yes siRNA-mediated SNHG7-knockdown decreased cell viability, increased apoptosis and compromised migration and invasion.Most importantly, we demonstrated that SNHG7-silencing delayed xenograft tumor progression, which was accompanied with increased miR-449a and decreased Ki67 intensity. 32880813 SNHG8 LncRNA Homo sapiens Heart Injuries H9C2 cell Interaction(miR-335 and RASA1 expression) Western Blot//Bioinformatics Analysis//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//EdU Staining However, SNHG8 siRNA did not further reduce apoptosis, demonstrating that SNHG8 may act through RASA1, and RASA1 may mediate the protection of SNHG8 siRNA in HI/R myocardial injury. Thus, inhibition of lncRNA SNHG8 alleviated HI/R?induced myocardial damage by regulating miR?335 and RASA1. Yes Silencing of RASA1 protected against HI/R?induced H9C2 cell injury. 34165173 SNHG8 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Interaction(miR-335-5p/PYGO2 axis) RNA Pull-Down//Transfection//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay SNHG8 expression was significantly up-regulated in TNBC cells. Moreover, SNHG8 acted as a sponge to sequester miR-335-5p in TNBC cells. Besides, PYGO2 was proven as a target gene of miR-335-5p, and SNHG8 promoted TNBC cell proliferation, migration and EMT process through regulating miR-335-5p and PYGO2. Yes SNHG8 silencing obviously inhibited TNBC cell proliferation, migration and EMT process. 34362407 SNHG8 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells regulation[miR-656-3p/SATB1 axis] Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found SNHG8 level was increased expression in NPC tissues and cells.Furthermore, we showed SNHG8 serves as a sponge for miR-656-3p to regulate SATB1 expression, and participated in NPC progression. Yes In vitro assays revealed that SNHG8 stimulates NPC cell proliferation, colony formation, cell migration, and cell invasion. In vivo assay confirmed knockdown of SNHG8 could hamper tumor growth. 32920509 SNHG8 LncRNA Homo sapiens Nasopharyngeal carcinoma NC cells Interaction(miR-588/HMGA2 axis) In Vivo Experiment//Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay SNHG8 was highly expressed in NC cells. SNHG8 targeted miR-588. Inhibition of miR-588 could partially reverse the knockdown of SNHG8 in NC cells, and miR-588 targeted HMGA2. In conclusion, SNHG8 promotes proliferation, migration, and invasion of NC cells through miR-588/HMGA2 in NC as an oncogene. The prognosis of the patients with NC in the high expression levels of SNHG8 was poorer than that in the low expression levels.The expression of SNHG8 was closely related to tumor size, TNM stage, and distal metastasis. Yes Knockdown of SNHG8 inhibited cell proliferation, migration, and invasion of NC. 35080988 SNHG8 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells interaction[miR-542-3p/CCND1/ CDK6] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay SNHG8 was over-expressed in NSCLC tissues and cells.SNHG8 knockdown inhibited NSCLC cell proliferation in vitro and in vivo, arrested cell cycle in the G0/G1 phase via targeting miR-542-3p/CCND1/ CDK6, and induced cell apoptosis via activation of Caspase-3. Patients with high SNHG8 expression have poorer overall survival (OS) and progression-free survival (PFS) than the patients with low SNHG8 expression. Yes SNHG8 knockdown inhibited NSCLC cell proliferation in vitro and in vivo, arrested cell cycle in the G0/G1 phase via targeting miR-542-3p/CCND1/ CDK6, and induced cell apoptosis via activation of Caspase-3. 30275712 SNHG8 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(miR-384/HOXB7) Western Blot//qRT-PCR//RIP//IHC//Bioinformatics Analysis//Transwell Assay SNHG8 was up-regulated in PCa tissues and cells. SNHG8 functioned as a molecular sponge to repress miR-384. The effects of SNHG8 knockdown on PCa cell proliferation, migration and invasion were counteracted by miR-384 inhibition. HOXB7 was confirmed to be a target gene of miR-384. SNHG8 knockdown repressed HOXB7 expression via targeting miR-384. Yes Silencing of SNHG8 suppressed the proliferation, migration and invasion of PCa cells. 33450101 SNHG8 LncRNA Homo sapiens Melanoma melanoma tissues and cells Interaction(miR-656-3p/SERBP1 axis) Bioinformatics Analysis In this study, lncRNA SNHG8 expression were upregulated in melanoma tissues and cells, and lncRNA SNHG8 knockdown reduced melanoma cell viability, migration and invasion. lncRNA SNHG8 expression could be induced by transcription factor YY1. In addition, we found that miR-656 could directly bind to lncRNA SNHG8 and SERPINE1 mRNA binding protein 1 (SERBP1). Rescue assays indicated that miR-656 overexpression inhibited the aforementioned cellular activities in melanoma cells, which were reversed by SERBP1 overexpression. In conclusion, this work elucidated that YY1-induced upregulation of lncRNA SNHG8 boosted the development of melanoma via the miR-656-3p/SERBP1 axis, providing a novel therapeutic strategy for melanoma treatment. Yes In this study, lncRNA SNHG8 expression were upregulated in melanoma tissues and cells, and lncRNA SNHG8 knockdown reduced melanoma cell viability, migration and invasion. 35156513 SNHG8 LncRNA Homo sapiens Myocardial Infarction myocardial tissue Interaction(PTBP1/ALAS2 ) RNA Pull-Down//Western Blot//Transfection//qPCR//RIP//MTT//H&E Staining//ELISA//IHC lncRNA-SNHG8 knockdown in MI mice was reduced myocardial infarction size, alleviated myocardial tissue injury and oxidative stress, and inhibited ALAS2 expression in myocardial tissue. RNA pulldown and RIP assays showed that lncRNA-SNHG8 binged with PTBP1 and PTBP1 interacted with ALAS2 mRNA. Yes Knockdown of lncRNA-SNHG8, METTL3 or PTBP1 in MI cells enhanced viability of myocardial cells, attenuated ROS release and MDA level, increased SOD level, alleviated oxidative stress. ALAS overexpression attenuated the corresponding effect of knockdown of lncRNA-SNHG8 and/or PTBP1 on MI cells. 36282350 SNHG8 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues and cells Interaction(miR-335-5p) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay The expression of SNHG8 was evaluated in several DLBCL cell lines and a normal lymphocyte cell line. It was found that SNHG8 was overexpressed in DLBCL tissues and cells in comparison with their normal counterparts. MiR-335-5p was predicted to be a potential target of SNHG8 by using the bioinformatics analysis, and the interaction between the two was validated by using the dual luciferase assay. In addition, the knockdown of SNHG8 increased the level of miR-335-5p, whereas miR-335-5p mimic decreased the expression of SNHG8. Yes The results showed that the knockdown of SNHG8 significantly inhibited DLBCL cell proliferation and colony formation while promoting cell apoptosis. Moreover, the knockdown of SNHG8 reduced the expression of Ki-67, proliferating cell nuclear antigen (PCNA), and Bcl-2 and enhanced the expression of Bax and cleaved caspase 3/9. 33816305 SNHG7-1 LncRNA Homo sapiens Abortion, Spontaneous cell lines Regulation[ targeted by miR-34a via Wnt/β-catenin signaling pathway] qRT-PCR The qRT-PCR assay SNHG7-1 showed that the expression level was downregulated in RSA and HTR-8/SVneo cells. In short, the current study suggests SNHG7-1 plays as an important role in RSA progression targeted by miR-34a via Wnt/β-catenin signaling pathway, providing a novel insight for the pathogenesis and underlying therapeutic target for RSA. Yes In addition, the growth rate of cells transfected with si-SNHG7-1 was significantly decreased compared to that with si-NC, which was reversed by miR-34a targeted with 3'-UTR. 30788002 SNHG7 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-122-5p/FOXK2 Axis) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay To begin with, SNHG7 was upregulated, while miR-122-5p was downregulated in HCC tissues and cells. Furthermore, miR-122-5p targeted FOXK2 and miR-122-5p recovered the effects of FOXK2 downregulation on cell growth and metastasis in HCC cells. Besides, SNHG7 facilitated HCC tumor growth in vivo through the miR-122-5p/FOXK2 axis. Yes Downregulation of SNHG7 inhibited cell growth and metastasis. Interestingly, SNHG7 could abolish the effects of miR-122-5p on HCC cells.Besides, SNHG7 facilitated HCC tumor growth in vivo through the miR-122-5p/FOXK2 axis. 33738672 SNHG7-003 LncRNA Homo sapiens Atherosclerosis VSMCs Regulation(miR‑1306‑5p/SIRT7 signaling pathway) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results revealed that the SNHG7‑003 expression levels were downregulated in VSMCs exposed to ox‑LDL, while the overexpression (OE) of SNHG7‑003 significantly inhibited the proliferation, migration and invasion of VSMCs induced by ox‑LDL. Transfection with miR‑1306‑5p mimic abrogated the effects of the inhibitory effects induced by SNHG7‑003 OE. SIRT7 was validated to be a target gene of miR‑1306‑5p, exhibiting similar inhibitory effects as SNHG7‑003 in AS. It was also discovered to be involved in the regulatory effects of the SNHG7‑003/miR‑1306‑5p axis in VSMCs. On the whole, the findings of the present study indicate that SNHG7‑003 may inhibit the proliferation, migration and invasion of VSMCs via the miR‑1306‑5p/SIRT7 signaling pathway. These findings may provide a novel basis for the development of treatment strategies for AS. Yes The results revealed that the SNHG7‑003 expression levels were downregulated in VSMCs exposed to ox‑LDL, while the overexpression (OE) of SNHG7‑003 significantly inhibited the proliferation, migration and invasion of VSMCs induced by ox‑LDL. 33416100 SNHG7 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Regulation[miR-34a-Snail-EMT axis ] qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay In our study, the levels of SNHG7 expression in gastric cancer tissues and cell lines were severally higher than in normal adjacent tissues and gastric mucosal epithelial cells.The studies in vitro revealed that SNHG7 directly binds to miR-34a and negatively regulates miR-34a expression, and SNHG7 enhances gastric cancer cell migration and invasion through sExpression[Expression[up-expression]-expression]pressing miR-34a-Snail-EMT axis. Moreover, high SNHG7 expression was positively correlated with TNM stage, depth of invasion, lymph-node metastasis and distant metastasis in gastric cancer patients. Furthermore, the multivariate Cox proportional hazard analysis further showed high SNHG7 expression was an independent poor prognostic factor for overall survival in gastric cancer patients. Yes The results of transwell migration and invasion assays showed Expression[down-expression]-regulation of SNHG7 obviously inhibited gastric cancer cell migration and invasion (P < 0.001, P < 0.001, Figure 4(a,b)), and Expression[Expression[up-expression]-expression]-regulation of SNHG7 remarkably accelerated gastric cancer cell migration and invasion (P < 0.001, P < 0.001, Figure 4(a,b)). 31814518 SNHG7 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cells Interaction(miR-485-5p) Wound Healing Assay//CCK8//RIP//qRT-PCR//Luciferase Report Assay//Transwell Assay SNHG7 expression was increased in human gastric cancer tissues and cells. The dual-luciferase reporter assay and RIP experiments proved that miR-485-5p was a direct target of SNHG7. At the same time, further experiments demonstrated that miR-485-5p inhibition reversed the suppression of SNHG7 knockdown on gastric cancer cells proliferation, migration, and invasion. Yes Knockdown of SNHG7 could notably inhibit the gastric cancer cells proliferation, migration, and invasion. 34512753 SNHG7 LncRNA Homo sapiens Breast Neoplasms breast cancer,cell lines (MCF-7, MDA-MB-231, MDA-MB-157, and MDA-MB-435) Interaction[miR-34a] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay we found that SNHG7 was significantly Expression[Expression[up-expression]-expression]-regulated in breast cancer tissues and cell lines.In terms of mechanism, miR-34a was confirmed to be the target of SNHG7, and SNHG7 could sponge miR-34a to inhibit the expression of miR-34a. In vivo and in vitro experiments both showed that SNHG7 targeted miR-34a and promoted epithelial-to-mesenchymal transition (EMT) initiation and the Notch-1 pathway in breast cancer. Yes SNHG7 knockExpression[down-expression] significantly inhibited MCF-7 cell proliferation and invasion, while SNHG7 overexpression dramatically promoted T47D cell proliferation and invasion. 31132353 SNHG7 LncRNA Homo sapiens Breast Neoplasms Breast Cancer tissues,cell lines Interaction[miR-34a-5p] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay LncRNA-SNHG7 was up-regulated in both breast cancer tissues and breast cancer cell lines. LncRNA-SNHG7 targeted miR-34a-5p to regulate LDHA expression and glycolysis. c-Myc bound to promoter of lncRNA-SNHG7 and positively regulated lncRNA-SNHG7 expression. Yes Knocking down lncRNA-SNHG7 inhibited breast cancer cell proliferation while overexpressing lncRNA-SNHG7 enhanced cell proliferation. Knocking down lncRNA-SNHG7 resulted in decreased expression of lactate dehydrogenase A (LDHA) and decreased glycolysis. 31897328 SNHG7 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues, cell lines Interaction[sponging miRNA-381] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay SNHG7 was found to be significantly upregulated in breast cancer tissues when compared with normal tissues. Breast cancer cell lines showed higher levels of SNHG7 than normal breast epithelial cell line. Yes The knockdown of SNHG7 by siRNA could remarkably repress breast cancer cell proliferation and invasion. Moreover, miRNA-381 was newly confirmed as a direct target of SNHG7 and it mediated the suppressing effects of SNHG7 on breast cancer cells. 31378900 SNHG7 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines regulation[regulating miR-15a expression] qRT-PCR//Luciferase Report Assay//Transwell Assay Compared with adjacent normal tissues, the expression of SNHG7 was significantly increased in breast cancer tissues; the expression of SNHG7 was the highest in breast cancer cells MCF7 and T47D; the expression level of SNHG7 was not notably different among breast cancer patients of different genders and age groups, and the difference was not statistically significant (p>0.05).SNHG7 plays an important role in the development of breast cancer. SNHG7 can affect the proliferation and invasion of breast cancer cells through its targeted regulation of miR-15a activity. Yes The inhibition of SNHG7 led to constrained proliferation and invasion of breast cancer cells. The tumor volume and weight of the tumor-bearing mice in the si-SNHG7 group were significantly lower than those in the non-specific control (NC) group. 33099915 SNHG7 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[regulating miR-122-5p and RPL4] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, we found that SNHG7 was highly expressed in HCC tissues compared to non-tumor tissues. Data from public databases consistently indicated the up-regulated expression of SNHG7 in HCC. Furthermore, the levels of SNHG7 were up-regulated in four HCC cell lines (Huh7, Hep3B, HCCLM3, MHCC97 H) compared with LO2 cells. In conclusion, we demonstrated that SNHG7 expression was up-regulated in HCC. SNHG7 contributed to HCC progression by regulating miR-122-5p and RPL4. Interestingly, the elevated expression of SNHG7 was closely correlated with advanced tumor stages, high tumor grades, vascular invasion and poor prognosis of HCC. Yes Knockdown of SNHG7 markedly inhibited cell proliferation, migration and invasion in HCCLM3 and MHCC97H cells, and prominently suppressed the growth and metastasis of HCCLM3 cells in vivo. 31545291 SNHG7 LncRNA Homo sapiens Neuroblastoma NB tissues Interaction[miR-653-5p/STAT2 pathway] qRT-PCR Our study revealed that SNHG7 expression was markedly higher in NB tissues than that in nontumor tissues. Jointly, our findings elucidated SNHG7 facilitated NB progression through the miR-653-5p/STAT2 pathway, providing a novel therapeutic target and prognostic biomarker for this disease. Besides, upregulated SNHG7 was greatly correlated with poor overall survival of NB patients. Yes Functionally, the loss-of-function assays demonstrated that knockdown of SNHG7 inhibited cell proliferation, migration, invasion, and epithelial-mesenchymal transition in NB cells. 30623419 SNHG6 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells Expression[highly expressed] qRT-PCR//Luciferase Report Assay//RNA Pull-Down SNHG6 was expressed at a high level in CC cells. Yes Silenced SNHG6 suppressed cell proliferation but promoted cell apoptosis. 32884447 SNHG6 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation[miR-181a-5p/E2F5 axis] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay In this study, we found that SNHG6 was significantly upregulated in CRC tissues and cell lines, compared with normal tissues and normal colorectal epithelial cell line NCM460, respectively. Taken together, these results demonstrated that SNHG6 plays a crucial role in CRC progression via miR-181a-5p/E2F5 axis. High expression of SNHG6 was positively correlated with tumor size, advanced TNM stage, and distant metastasis. Survival analyses revealed that SHNG6 was significantly associated with poor clinical outcomes and could serve as an independent prognostic factor. Yes Loss-of-function studies demonstrated that SNHG6 knockdown inhibited CRC cell proliferation, induced G0/G1 arrest, promoted apoptosis, suppressed CRC cell migration and invasion, and restrained tumor growth. 30666158 SNHG6 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation[miR-26a/EZH2 axis ] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Our data indicated that SNHG6 and EZH2 mRNA were upregulated, and miR-26a was downregulated in CRC tissues and cell lines. SNHG6 knockdown suppressed cell migration, invasion, and EMT at least partly by sponging miR-26a and regulating EZH2 expression in CRC cells, providing a strategy for blocking CRC metastasis. Yes SNHG6 knockdown suppressed the migration, invasion, and epithelial-mesenchymal transition (EMT) of CRC cells. 31118686 SNHG6 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines regulation[miR-181,JAK2] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay SNHG6 was significantly up-regulated in CRC samples. SNHG6 can exert a cancer-promoting effect in CRC by targeting miR-181 family members and up-regulating JAK2. Yes The knockdown of SNHG6 reduced the proliferation of CRC cells and promoted the apoptosis, whereas the over-expression of SNHG6 had the opposite effect. 32840014 SNHG6 LncRNA Homo sapiens Carcinoma, Hepatocellular Interaction[sponging let-7c-5p] qRT-PCR In the present study, we globally investigated the expression of SNHG6 in 31 cancer type, and we found that SNHG6 was highly expressed in various cancers, especially in HCC. Yes Gain of function and loss of function assays showed that SNHG6 promoted HCC cell proliferation. 31563323 SNHG6 LncRNA Homo sapiens Carcinoma, Hepatocellular Regulation(HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization) qRT-PCR//RNA Pull-Down//RIP//FISH SNHG6 reduced the mRNA levels of lysine methyltransferase, SET domain containing 7 (SETD7) and leucine zipper transcription factor-like 1 (LZTFL1) by posttranscriptional destabilization. Silencing of SETD7 or LZTFL1 reversed the suppressive effects of SNHG6 knockdown on HCC progression. Heterogeneous nuclear ribonucleoprotein L (HNRNPL) and polypyrimidine tract binding protein 1 (PTBP1) were identified as SNHG6-interacting proteins that bind to SETD7 or LZTFL1 mRNA. Yes Silencing of SETD7 or LZTFL1 reversed the suppressive effects of SNHG6 knockdown on HCC progression. 34252487 SNHG6 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-6509-5p and HIF1A) qRT-PCR We found SNHG6 was highly expressed in HCC tissues. Next, using Hep3B and Huh7 cells, we confirmed knockdown of SNHG6 reduced the proliferation, migration and invasion abilities in vitro. Also, by bioinformatics analysis, further molecular and cellular experiments, we found miR-6509-5p bound to SNHG6 directly, and the expression level of HIF1A was regulated through SNHG6/miR-6509-5p axis. Finally, we found that down-regulation of SNHG6 dramatically reduced the tumor growth ability of Huh7 cells in vivo Yes we confirmed knockdown of SNHG6 reduced the proliferation, migration and invasion abilities in vitro. Also, by bioinformatics analysis, further molecular and cellular experiments, we found miR-6509-5p bound to SNHG6 directly, and the expression level of HIF1A was regulated through SNHG6/miR-6509-5p axis. Finally, we found that down-regulation of SNHG6 dramatically reduced the tumor growth ability of Huh7 cells in vivo. 33663502 SNHG6 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and Interaction(FAF2–mTOR) qRT-PCR Here, we report that the long non-coding RNA (lncRNA) SNHG6 increases progression from non-alcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC) by modulating cholesterol-induced mTORC1 activation. Mechanistically, cholesterol binds ER-anchored FAF2 protein to promote the formation of a SNHG6–FAF2–mTOR complex. Yes As a putative cholesterol effector, SNHG6 enhances cholesterol-dependent mTORC1 lysosomal recruitment and activation via enhancing FAF2–mTOR interaction at ER–lysosome contacts, thereby coordinating mTORC1 kinase cascade activation with cellular cholesterol biosynthesis in a self-amplified cycle to accelerate cholesterol-driven NAFLD–HCC development. 35995997 SNHG6 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Regulation(BOP1) qRT-PCR SNHG6 and BOP1 levels were increased in HCC tissues and cells. SNHG6 could bind the BOP1 protein and enhance its stability. BOP1 overexpression rescued the change of proliferation, apoptosis, and glycolysis in HCCLM3 and SMMC-7721 cells. SNHG6 and BOP1 were prognostic factors in HCC patients and significantly correlated to TP53 mutant and tumor grade. Yes SNHG6 promoted proliferation, inhibited apoptosis, enhanced glucose uptake and lactate production, decreased OCR, and increased ECAR in HCC cell lines. 36605586 SNHG6 LncRNA Homo sapiens Triple Negative Breast Neoplasms Breast cancer cell lines Interaction(miR-125b-5p/BMPR1B Axis) In Vivo Experiment//IHC//Western Blot//Transfection//Wound Healing Assay//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Breast cancer cell lines demonstrated higher lncRNA SNHG6 expressions, particularly TNBC cell lines, in contrast to normal breast epithelial cell lines. miR-125b-5p and lncRNA SNHG6/BMPR1B both possessed direct binding sites for each other which was validated utilizing a dual-luciferase reporter assay. Decreasing lncRNA SNHG6 expression in TNBC cells upregulated miR-125b-5p expression. Another side, inhibiting miR-125b-5p upregulated BMPR1B expression in these cells. Yes lncRNA SNHG6 knockdown inhibited TNBC cell proliferation, migration, while promoted cell apoptosis. Furthermore, suppressed lncRNA SNHG6 expressions resulted in lower tumor weights and volumes in a xenograft mouse model, as evidenced by Ki-67 and c-Caspase-3 expression profiles in tumor tissues. 34026654 SNHG6 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues ,CRC cell lines Regulation[TGF-β/Smad signaling pathway ] CCK8//qRT-PCR//Transwell Assay//Western Blot qRT-PCR confirmed that the expression of SNHG6 was significantly upregulated in CRC tissues and cell lines. UPF1 was upregulated and ZEB1 was decreased when SNHG6 knockdown, regulating the TGF-β/Smad pathway and inducing EMT respectively. CRC patients with high levels of SNHG6 had a significantly shorter overall survival than those with low levels of SNHG6 (P = 0.0162). Yes Upregulation of SNHG6 expression induced RKO and HCT116 cell proliferation as well as RKO cell metastasis, while downregulation of SNHG6 expression supressed the proliferation and metastasis of RKO cells and tumor growth in vivo. 30662328 SNHG6 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-543/LMO3 axis] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that SNHG6 was obviously upregulated in glioma tissues and cells. SNHG6 served as an oncogene and played a vital role in glioma development through miR-543/LMO3 axis. Yes SNHG6 knockdown significantly repressed glioma cell proliferation, migration and invasion, and induced apoptosis. 32613482 SNHG6 LncRNA Homo sapiens Glioma glioma cell lines Expression(lower expressed) Transfection//Cell Apoptosis Assay We screened four glioma cell lines; H4, A172, U87MG, and SW088 and grouped them based on high vs. low SNHG6 expression. The regulation was not found to be reciprocal as silencing of Notch1 and Sox2 failed to affect SNHG6 levels. The levels of SNHG6 and Notch1 were also found elevated in Grade IV glioma patients (n = 4) relative to Grade II glioma patients (n = 5). Yes Transfections with SNHG6 specific siRNA resulted in induction of apoptosis of high SNHG6 expressing A172 and U87MG cells. This was accompanied by inhibition of EMT and downregulation of EMT-modulating factor Notch1, β-catenin activity and the cancer stem cell marker Sox2. 34485294 SNHG6 LncRNA Homo sapiens Glioma glioma tissues and glioma cells Interaction(p21) Western Blot//Flow Cytometry//qRT-PCR//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay In this study, the high expression of SNHG6 was tested in both glioma tissues and glioma cells. Finally, we identified that p21 was involved in glioma cell proliferation after SNHG6 was downregulated. Yes However, results of loss-of-function assays revealed that silenced SNHG6 exerted the inhibitory function on glioma cell growth. Flow cytometric analysis was performed in glioma cells to detect the anti-oncogenic effects of silenced SNHG6 on cell cycle and apoptosis. 29579705 SNHG6 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction(miR-26a-5p/ARPP19 axis) RNA Pull-Down//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We observed that SNHG6 expression was enhanced in NPC tissues and cells. MiR-26a-5p was predicted and validated to interact with SNHG6, and miR-26a-5p expression was markedly elevated in NPC after SNHG6 silence. Moreover, miR-26a-5p inhibitor rescued the suppressive effect of SNHG6 depletion on NPC cell viability, migration and invasion. Besides, ARPP19 was a target of SNHG6 and positively regulated by SNHG6. Our results indicated that SNHG6 regulated NPC progression through modulating miR-26a-5/ARPP19 axis Yes SNHG6 deletion attenuated NPC cell viability and metastasis. 33744438 SNHG6 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissue samples and cell lines Interaction(miR-186/CDK6 axis) Western Blot//Transfection//EdU Staining//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis SNHG6 was highly expressed in PTC tissue samples and cell lines.miR-186 is the downstream target of SNHG6. SNHG6 regulates the proliferation of PTC cells through miR-186. In addition, CDK6 is the target gene of miR-186, which can inhibit the expression of CDK6 protein. SNHG6 can promote the expression of CDK6 by regulating miR-186. Yes In vitro, overexpression of SNHG6 promoted the proliferation of PTC cells, while silencing SNHG6 inhibited the proliferation of PTC cells. 34804881 SNHG6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues regulation[miR-101-3p/EZH2 axis ] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot The long non-coding RNA (lncRNA) SNHG6 was significantly upregulated in esophageal squamous-cell carcinoma (ESCC).In this study, we found that upregulation of the lncRNA SNHG6 inhibited apoptosis via miR-101-3p/EZH2 axis in ESCC. Yes The long non-coding RNA (lncRNA) SNHG6 was significantly upregulated in esophageal squamous-cell carcinoma (ESCC), and it promoted ESCC cell proliferation, invasion, and migration. 33192074 SNHG6 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues interaction[microRNA-26a-5p,FUBP1 ] qRT-PCR//RNA Pull-Down//Luciferase Report Assay Compared with that in normal tissues, SNHG6 was highly expressed in PC tissues (1.00 ± 0.05 vs. 1.56 ± 0.06, t = 16.03, P < 0.001). Silencing SNHG6 might ameliorate PC through inhibition of FUBP1 by sponging miR-26a-5p, thus providing further supporting evidence for its use in PC treatment. Yes Compared with the levels in the si-negative control group, SNHG6 (0.97 ± 0.05 vs. 0.21 ± 0.06, t = 16.85, P < 0.001), N-cadherin (0.74 ± 0.05 vs. 0.41 ± 0.04, t = 8.93, P < 0.001), Vimentin (0.55 ± 0.04 vs. 0.25 ± 0.03, t = 10.39, P < 0.001), and β-catenin (0.62 ± 0.05 vs. 0.32 ± 0.03, t = 8.91, P < 0.001) were decreased, while E-cadherin (0.65 ± 0.06 vs. 1.36 ± 0.07, t = 13.34, P < 0.001) was increased after SNHG6 knockdown or miR-26a-5p overexpression, accompanied by inhibited cell proliferation, migration, and invasion. 32433053 SNHG6 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cell lines interaction[miR-101-3p,E2F8] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay Our results proved that the expression SNHG6 was upregulated in CCA tissues and cell lines. Further mechanistic studies revealed that SNHG6 could compete with the transcription factor E2F8 to bind with miR-101-3p, thus affecting E2F8 expression. Yes Ectopic expression of SNHG6 promoted cell proliferation, cell cycle progression, migration, and angiogenesis in CCA cells, whereas knockdown of SNHG6 repressed these cellular processes. 32226515 SNHG6 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Interaction[sponging miR-26a/b and miR-214] RNA Pull-Down//ChIP//Wound Healing Assay//CCK8//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay We found that elevated SNHG6 expression was associated with poor prognosis and CRC progression. Mechanistically, we found that SNHG6 expressed predominantly in the cytoplasm. SNHG6 could interact with miR-26a, miR-26b, and miR-214 and regulate their common target EZH2. Yes Functional studies showed that SNHG6 promoted CRC cell growth, migration, and invasion both in vitro and in vivo. 30626446 SNHG6 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Regulation[P21 ] CCK8//qRT-PCR//RIP//ChIP Here we found that SNHG6 was upregulated and its expression levels were positively correlated with advanced tumor stage in colorectal cancer. Survival analysis suggested that higher expression of SNHG6 predicted poor prognosis in patients with colorectal cancer.Taken together, our study demonstrates that SNHG6 promotes tumor growth via repression of p21 in colorectal cancer, which may provide a promising target for novel anticancer therapeutics. Here we found that SNHG6 was upregulated and its expression levels were positively correlated with advanced tumor stage in colorectal cancer. Survival analysis suggested that higher expression of SNHG6 predicted poor prognosis in patients with colorectal cancer. Yes Functional studies indicated that SNHG6 could promote cell proliferation via a direct suppression of p21 expression in colorectal cancer cells. 30157475 SNHG7 LncRNA Homo sapiens Neuroblastoma NB tissues and cell lines interaction[sponging miR-323a-5p and miR-342-5p] qRT-PCR//Luciferase Report Assay//RIP//Transwell Assay We found that SNHG7 was upregulated in NB tissues and cell lines, and high SNHG7 level was relevant to poor prognosis of NB patients.In conclusion, our study suggested that SNHG7 silencing hindered NB progression at least partly though sponging miR-323a-5p and miR-342-5p, illuminating its potential value as a therapeutic target. We found that SNHG7 was upregulated in NB tissues and cell lines, and high SNHG7 level was relevant to poor prognosis of NB patients. Yes SNHG7 silencing resulted in the repression of NB cell migration, invasion and glycolysis. 32534305 SNHG6 LncRNA Homo sapiens Stomach Neoplasms Thirty-five GC tissues and paired normal tissues Interaction(miR-1297/BCL-2 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay We found that SNHG6 and BCL-2 were up-regulated, while miR-1297 expression was declined in GC tissues and DDP-resistant cells. Besides, SNHG6 positively regulated BCL-2 expression by sponging miR-1297. Yes Moreover, depletion of SNHG6 or gain of miR-1297 could repress DDP resistance, proliferation and metastasis of DDP-resistant cells, which was weakened by miR-1297 inhibition or BCL-2 overexpression. 34821362 SNHG7 LncRNA Homo sapiens Uveal melanoma UM tissues and cell lines Interaction[downregulation of EZH2 ] CCK8//qRT-PCR//Western Blot The results of the present study indicated that low expression of SNHG7 was associated with poor prognosis. Western blot analysis results revealed that overexpression of SNHG7 downregulated EZH2 protein expression levels in UM cell lines. The results of the present study demonstrated that SNHG7 inhibited malignant transformation of UM cells by regulating EZH2 expression. Yes Furthermore, increasing the expression of SNHG7 inhibited the proliferation of UM cells, suppressed cell cycle progression and promoted apoptosis. 32002036 SNHG7 LncRNA Homo sapiens Diabetic Retinopathy HRMECs Interaction(miR-34a-5p/XBP1 axis) RNA Pull-Down//Western Blot//Tube Formation Assay//qRT-PCR//Luciferase Report Assay//IF LncRNA SNHG7 sponged to and negatively regulated miR-34a-5p. SNHG7 overexpression repressed HG induced endothelial-mesenchymal transition (EndMT) and tube formation of HRMECs, while miR-34a-5p overexpression could reverse this effect. miR-34a-5p targeted and negative regulated XBP1. Yes LncRNA SNHG7 sponged to and negatively regulated miR-34a-5p. SNHG7 overexpression repressed HG induced endothelial-mesenchymal transition (EndMT) and tube formation of HRMECs, while miR-34a-5p overexpression could reverse this effect. 33600866 SNHG7 LncRNA Homo sapiens Colonic Neoplasms colon tumor tissues and cells Interaction[MicroRNA-193b] qRT-PCR Stepwise upregulated SNHG7 in colon advanced adenomas and early-stage cancer negatively correlates with miR-193b level, the direct interaction was confirmed in vitro. Yes SNHG7 silencing in HT29 cells decreased proliferation and promoted apoptosis by inhibiting K-ras/ERK/cyclinD1. 31721543 SNHG7 LncRNA Homo sapiens Pre-Eclampsia PE pregnancies Interaction(miR-214-5p/TWIST1 axis) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay In PE pregnancies, SNHG7 and TWIST1 were decreased, while miR-214-5p was increased.The elevated miR-214-5p and decreased TWIST1 partly eliminated the promoting effects of SNHG7 up-regulation on the viability and metastasis of JEG-3 cells. Yes In PE pregnancies, SNHG7 and TWIST1 were decreased, while miR-214-5p was increased.The elevated miR-214-5p and decreased TWIST1 partly eliminated the promoting effects of SNHG7 up-regulation on the viability and metastasis of JEG-3 cells. 34606403 SNHG7 LncRNA Homo sapiens Fractures, Bone femoral neck fracture tissues Interaction[miR-9 ] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//ELISA In the current study, we observed SNHG7 was down-regulated in femoral neck fracture tissues. Bioinformatics analysis revealed SNHG7 acts as a molecular sponge for miR-9 and MiR-9 directly targets with 3'-UTR of TGFBR2. Yes In addition, SNHG7 knockdown inhibited proliferation and migration, induced apoptosis, reduced activity in osteoblast cells in vitro. 30899396 Snhg7 LncRNA Mus musculus Myocardial Infarction cardiac tissues of mice with MI and Ang-II-induced CFs Interaction( miR-455-3p/PTAFR axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//ELISA LncRNA SNHG7 and PTAFR were upregulated, whereas miR-455-3p was downregulated in cardiac tissues of mice with MI and Ang-II-induced CFs.LncRNA SNHG7 targeted miR-455-3p, and PTAFR was a target of miR-455-3p. LncRNA SNHG7 depletion exerted protective roles in apoptosis, fibrosis, and inflammation in Ang-II-induced CFs by regulating miR-455-3p/PTAFR axis, providing a potential molecular target for MI therapy. Yes SNHG7 depletion or miR-455-3p overexpression attenuated Ang-II-induced apoptosis, fibrosis, and inflammation in CFs, which was severally weakened by miR-455-3p inhibition or PTAFR upregulation. 33929392 SNHG7 LncRNA Rattus norvegicus Spinal Cord Injuries SCI model group Interaction(miR-449a/TNIP2/NF-κB signaling pathway) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay The results showed that lncRNA-SNHG7 was markedly downregulated in the SCI model group. LncRNA-SNHG7 directly bound to miR-499a, which in turn directly targeted TNIP2.In conclusion, lncRNA-SNHG7 modulates the apoptosis and inflammation of PC-12 cells by regulating the miR-449a/TNIP2/NF-κB signaling pathway. Yes In addition, TNIP2 was significantly decreased in SCI rats and lipopolysaccharide (LPS)-treated PC-12 cells. The in vitro results in PC-12 cells revealed that lncRNA-SNHG7 overexpression attenuated neuronal cell death and SCI-mediated inflammatory responses by regulating miR-449a expression. 35443851 SNHG6 LncRNA Homo sapiens Stomach Neoplasms GC tissues and serum Regulation[p21, JNK pathway,EZH2 ] qRT-PCR//FISH We found that SNHG6 was up-regulated in human GC tissues and serum.Our findings show that SNHG6 knockdown inhibits GC development by upregulating p21; this effect is dependent on the activation of the JNK pathway and suppression of EZH2 expression. Yes Knockdown of SNHG6 inhibited GC cell proliferation, induced cellular senescence, and reduced xenograft tumor growth in BALB/c nude mice. 30031062 SNHG6 LncRNA Homo sapiens Breast Neoplasms BC tissue and adjacent normal breast tissue,cell lines( MCF-10 A, BT-474, MDA-MB-231, ZR-75-30, MDA-MB-468 ,T-47D) Interaction[miR-26a-5p/MAPK6 ] Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay the expression of SNHG6 was significantly increased in BC tissues, compared with matched adjacent tissues.Consistently, the SNHG6 expression in five human BC cell lines was significantly higher than that of MCF-10 A cells.Therefore, our study may reveal a novel SNHG6/miR-26a-5p/MAPK6 pathway regulatory axis in BC pathogenesis. SNHG6 may serve as a potential prognostic and therapeutic target in the treatment of BC. Yes Knockdown of SNHG6 inhibited BC cell proliferation, migration and invasion in vitro and in vivo using CCK-8, Edu staining, transwell assays and nude mice model. 30522015 SNHG6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues,cell lines Expression[highly expressed] CCK8//qRT-PCR//Transwell Assay SNHG6 expression was upregulated in ESCC tissues and ESCCs. Upregulated SNHG6 expression was correlated with prognosis, lymph node metastasis, distant metastasis and TNM stage of ESCC patients. Yes Upregulated SNHG6 expression was correlated with prognosis, lymph node metastasis, distant metastasis and TNM stage of ESCC patients. 30899408 SNHG6 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[miR-26a/VASP axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Compared with adjacent normal tissues, breast cancer tissues showed higher expression level of VASP and lower miR-26a, while there was no statistical difference with SNHG6 (Fig. 1A-C). Furthermore, Kaplan-Meier survival analysis showed that expression of VASP was negatively correlated, while miR-26a was positively, to the prognosis of breast cancer patients. However, there was no statistical difference with SNHG6 (Fig. 1D-F). Yes Our study found that knockExpression[down-expression] of SNHG6 significantly inhibited the proliferation, migration and invasion of breast cancer cells MCF-7 and MDA-MB-231 cells. 31387807 SNHG6 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] qRT-PCR//Wound Healing Assay//MTT//Migration Assay We found that the expression of SNHG6 was significantly upregulated in primary high-grade and progesterone receptor (PR)-positive breast tumours. Yes Additional siRNA-based experiments revealed that SNHG6 silencing led to G1 cell cycle arrest in SK-BR-3 and MDA-MB-231 breast cancer-derived cells. Moreover, we found that SNHG6 silencing led to suppressed breast cancer cell proliferation by inducing apoptosis and senescence. 30826970 SNHG6 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-543/LAMC1 axis) IHC//Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay SNHG6 and LAMC1 were elevated, but miR-543 was reduced in BC tissues and cells. SNHG6 interacted directly with miR-543, while miR-543 targeted LAMC1.Overexpression of LAMC1 also blocked the effects of miR-543 on BC cell proliferation, migration, invasion, and EMT. Knockdown of SNHG6 restrained BC growth in vivo, while miR-543 inhibitor inhibited that suppression. Yes Knockdown of SNHG6 suppressed BC cell proliferation, migration, invasion, EMT, and PI3K/AKT pathway, but promoted cell apoptosis, while miR-543 inhibitor or overexpression of LAMC1 reversed those effects. Overexpression of LAMC1 also blocked the effects of miR-543 on BC cell proliferation, migration, invasion, and EMT. Knockdown of SNHG6 restrained BC growth in vivo, while miR-543 inhibitor inhibited that suppression. 33782812 SNHG6 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumors and cell lines regulation[miR-490-3p/RSF1 Axis] qRT-PCR//MTT//Western Blot SNHG6 and RSF1 expression were upregulated, whereas miR-490-3p was downregulated in NSCLC tumors and cell lines compared with normal tissues and cells. The authors demonstrated that SNHG6 promoted proliferation and inhibits apoptosis in NSCLC by regulating miR-490-3p/RSF1 axis, representing promising targeted therapeutic strategies against NSCLC. Yes However, SNHG6 knockdown hindered tumor growth in vivo by regulating RSF1 by targeting miR-490-3p. 32202941 SNHG6 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung LAC tissues regulation[miR-101-3p] qRT-PCR//MTT//RIP//Transwell Assay We found that increased expression of SNHG6 was associated with pathological stage and lymph node infiltration, and acted as an independent prognostic factor of tumor recurrence in patients with NSCLC.Our findings demonstrated that lncRNA SNHG6 contributed to the proliferation and invasion of NSCLC by downregulating miR-101-3p. We found that increased expression of SNHG6 was associated with pathological stage and lymph node infiltration, and acted as an independent prognostic factor of tumor recurrence in patients with NSCLC. Yes Silencing SNHG6 expression repressed cell growth and invasion in vitro and in vivo, but overexpression of SNHG6 reversed these effects. 32147945 SNHG6 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[ETS1 signaling] qRT-PCR//Luciferase Report Assay//RIP//Western Blot We found that SNHG6 expression was significantly increased in NSCLC tissues and cell lines and its high expression was correlated with malignant features of NSCLC. Yes In in vitro assays, knockdown of SNHG6 significantly depressed the proliferation vitality and migration activity of NSCLC cells. 32099396 SNHG6 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(p27/EZH2) CCK8//qRT-PCR//Western Blot In this study, through systematically screening GSE33532 and GSE29249 from Gene Expression Omnibus (GEO) database and bioinformatics analysis, we found the significant upregulation of SNHG6 in NSCLC. Mechanically, SNHG6 recruited EZH2 to the promoter region of p27 and increased H3K27me3 enrichment, thus epigenetically repressing the expression of p27, regulating the cell cycle, and promoting tumorigenesis of NSCLC. SNHG6 silencing restrained tumor growth in vivo and suppressed the expressions of cell cycle-related proteins in the G1/S transition. The activation of SNHG6 was driven by copy number amplification and high expression of SNHG6 indicated a poor prognosis. Yes Functionally, the knockdown of SNHG6 inhibited NSCLC cell proliferation, migration, and suppressed the G1/S transition of the cell cycle. SNHG6 overexpression had the opposite effects. 36494339 SNHG6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines Regulation[miR-186-5p/HIF1α Axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay LncRNA SNHG6 and HIF1α were upregulated, while miR-186-5p was downregulated in ESCC tissues and cell lines. A negative correlation between lncRNA SNHG6 and miR-186-5p expression was found in ESCC tissues. Similarly, there is a positive correlation between lncRNA SNHG6 and HIF1α expression in ESCC tissues. Conversely, miR-186-5p expression was negatively correlated with HIF1α expression in ESCC tissues. Furthermore, lncRNA SNHG6 was identified as a decoy for miR-186-5p, thereby promoting the expression of miR-186-5p target HIF1α. More significantly, restoration of SNHG6 or HIF1α could reverse the inhibitory effect of miR-186-5p on ESCC cell proliferation, migration, and invasion. Yes Knockdown of lncRNA SNHG6 inhibits ESCC cell proliferation, migration, and invasion 31853782 circFBL CircRNA Homo sapiens Myasthenia Gravis 35 MG patients and 11 volunteers without MG Interaction(miR-133/PAX7) In Vivo Experiment//qRT-PCR//Luciferase Report Assay//RNA-seq//IHC//EdU Staining Circ-FBL was significantly increased in MG patients. Bioinformatics and luciferase report analyses confirmed that miR-133 and PAX7 were the downstream targets of circ-FBL. Yes Overexpression of circ-FBL promoted myoblast proliferation by regulation of miR-133/PAX7. 34363272 circHIPK3 CircRNA Homo sapiens Myocardial Reperfusion Injury cell lines Interaction[binding to miRNA-124-3p ] qRT-PCR CircHIPK3 was highly expressed in HCM cells with simulated myocardial I/R relative to those with normoxic treatment. CircHIPK3 inhibits proliferative ability and induces apoptosis of cardiomyocytes after myocardial I/R injury by binding to miRNA-124-3p, which may serve as a potential therapeutic target for I/R. Yes Inhibited proliferation and accelerated apoptosis were observed in simulated HCM cells overexpressing circHIPK3. 31799682 hsa_circ_0050908 CircRNA Homo sapiens Myocardial Reperfusion Injury cardiomyocytes Interaction(miR-324-5p/TRAF3 axis) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//ELISA I/R stimulation up-regulated circ_0050908 expression in cardiomyocytes. Mechanistically, circ_0050908 directly targeted miR-324-5p, and miR-324-5p inhibition reversed the inhibitory action of circ_0050908 knockdown on myocardial I/R injury. TRAF3 was verified to be a target of miR-324-5p, and miR-324-5p suppressed I/R-induced apoptosis, inflammatory response, and oxidative stress in cardiomyocytes through TRAF3. Besides that, circ_0050908 could regulate TRAF3 expression by miR-324-5p. Yes Functional experiments suggested that circ_0050908 knockdown led to the rescue of apoptosis enhancement, inflammation, and oxidative stress induced by I/R in cardiomyocytes. 35413678 TP73-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Expression(highly expressed) Western Blot//Wound Healing Assay//qRT-PCR//MTT//cell invasion assay//Colony Formation Assay This study showed that lncRNA TP73-AS1 was up-regulated in cervical cancer tissues and cell lines (p < 0.001), and high expression of TP73-AS1 could be considered as an independent prognostic factor (p < 0.05). This study showed that lncRNA TP73-AS1 was up-regulated in cervical cancer tissues and cell lines (p < 0.001), and high expression of TP73-AS1 could be considered as an independent prognostic factor (p < 0.05). Yes Moreover, lncRNA TP73-AS1 promotes cervical cancer cell migration and invasion, and knockdown of TP73-AS1 inhibits the growth of cervical cancer cells (p < 0.001). 35316908 TP73-AS1 LncRNA Homo sapiens Osteosarcoma Osteosarcoma tissue,cell lines Expression[highly expressed] qRT-PCR In our results, TP73-AS1 was highly expressed in osteosarcoma tissue samples and cell lines compared with matching adjacent nontumor tissue specimens and a normal human osteoblast cell line, respectively. Moreover, high expression of TP73-AS1 was statistically associated with advanced Enneking stage, large tumor size, present distant metastasis, and poor histological grade, while exhibiting no statistical association with age, sex, and tumor site. The survival analyses showed that patients with osteosarcoma with high expression of TP73-AS1 obviously had lower overall survival than osteosarcoma patients with low expression of TP73-AS1, and high expression of TP73-AS1 was an independent poor prognostic factor for osteosarcoma patients. Yes The experiments in vitro indicated that inhibition of TP73-AS1 expression depressed osteosarcoma cell viability, migration, and invasion, and arrested cell cycle. 30216569 TP73-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute Bone marrow regulation[miR-21/PTEN Axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot TP73-AS1 was confirmed to be downregulated in AML.TP73-AS1 may regulate the miR-21/PTEN axis to affect cell proliferation in AML. Yes Cell proliferation analysis showed that overexpression of TP73-AS1 and PTEN led to a decreased proliferation rate of AML cells. 32412786 TP73-AS1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues Interaction(miR-200a) qRT-PCR//Luciferase Report Assay In this study, we identified a novel host factor, namely the LncRNA TP73-AS1, as overexpressed in PDAC tissues compared to adjacent healthy tissue samples. Mechanistically, we found that TP73-AS1 suppressed the expression of the known oncogenic miR-200a. Taken together, these data highlight the prognostic potential of TP73-AS1 for PC patients and highlight it as a potential anti-PDAC therapeutic target. The overexpression of TP-73-AS1 was found to correlate with both PDAC stage and lymph node metastasis. Yes To reveal its role in PDCA, we targeted TP73-AS1 using LnRNA inhibitors in a range of pancreatic cancer (PC) cell lines. We found that the inhibition of TP73-AS1 led to a loss of MMP14 expression in PC cells and significantly inhibited their migratory and invasive capacity. No effects of TP73-AS1 on cell survival or proliferation were observed. 33683827 TP73-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cancer tissues,cell lines Interaction[microRNA-329-3p] qRT-PCR//Luciferase Report Assay//RIP//Western Blot LncRNA TP73-AS1 was overexpressed in cervical cancer tissues and cells and was associated with reduced expression of miR-329-3p.Expression of SMAD2 down-regulated miR-329-3p and was associated with increased expression of TP73-AS1. LncRNA TP73-AS1 knockdown resulted in miR-329-3p silencing. In tumor xenografts, expression of TP73-AS1 reduced the tumor volume and down-regulated the expression levels of the SMAD2 gene. Yes Down-regulation of lncRNA TP73-AS1 inhibited cell proliferation, migration and invasion and increased miR-329-3p expression. 31663517 TP73-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms Cell lines Regulation[miR-329-3p/ARF1 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay LncRNA TP73-AS1 has been found to promote cancer progressions in various cancers. It is upregulated in cervical cancer cells. Meanwhile, miRNA-329-3p is downregulated in cervical cancer cells and could bind with both TP73-AS1 and ADP Ribosylation Factor 1 (ARF1). TP73-AS1 inhibited miR-329-3p expression while miR-329-3p inhibited ARF1 expression. More importantly, TP73-AS1 can positively regulate ARF1 expression. Based on all these experiments, TP73-AS1 regulates ARF1 expression by competitively binding with miR-329-3p, thus regulating cervical cancer progression. Yes It is upregulated in cervical cancer cells. The proliferation and migration ability of cervical cancer cells can also be boosted by TP73-AS1 in return. 31232491 TP73-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction[microRNA‑607/cyclin D2] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results revealed that the TP73‑AS1 level was upregulated in cervical cancer tissues (P<0.05) and predicted a poor 5‑year overall survival (P<0.05).In conclusion, the findings suggested that upregulation of TP73‑AS1 promoted cervical cancer progression by promoting CCND2 via the suppression of miR‑607 expression. The results revealed that the TP73‑AS1 level was upregulated in cervical cancer tissues (P<0.05) and predicted a poor 5‑year overall survival (P<0.05). Yes HeLa and CaSki cells transfected with siTP73‑AS1 exhibited reduced proliferation, migration and invasion abilities when compared with those in the siNC group (P<0.05).  31432138 TP73-AS1 LncRNA Homo sapiens Glioma cell lines regulation[miR-103a/GALNT7 pathway] CCK8//qRT-PCR//Colony Formation Assay Herein, we found that TP73-AS1 was up-regulated in glioma and was associated with a dismal prognosis.Altogether, our results established that TP73-AS1 facilitates the progression of glioma through competing for endogenous RNA (ceRNA) in a TP73-AS1/miR-103a/GALNT7 loop. Previous research posited that the up-regulation of LncRNA TP73-AS1 (TP73-AS1) in glioma is linked to low survival rates. Yes The silencing of TP73-AS1 repressed the multiplication of glioma cells and caused cell death. 32416102 TP73-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cells Expression(lower expressed) Western Blot//Migration Assay//CCK8//qRT-PCR//Invasion Assay//Transwell Assay We identified that the expression level of TP73-AS1 was significantly down-regulated in bladder cancer tissues and cells compared to adjacent non-tumor tissues. In addition, overexpression of TP73-AS1 diminished epithelial-mesenchymal transition (EMT) through inhibiting the expression of vimentin, snail, MMP-2, and MMP-9 and upregulating the expression levels of E-cadherin. Kaplan-Meier survival analysis found that patients with low TP73-AS1 expression level had shorter overall survival and progression-free survival than those with high TP73-AS1 expression. Yes Moreover, we showed that overexpression of TP73-AS1 could inhibit cell growth, arrest cell cycle, reduce cell migration and invasion, and promote cell apotosis in vitro study. 29625110 TP73-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction(miR-495/ JAM-A) Western Blot//Transfection//qRT-PCR//MTT//migration assay//Luciferase Report Assay//Transwell Assay TP73-AS1 and JAM-A were significantly upregulated while miR-495 was markedly downregulated in NPC tissues and cell lines compared to normal controls. TP73-AS1 targeted miR-495 and negatively regulated its expression. TP73-AS1 upregulated the expression of JAM-A through miR-495. TP73-AS1 mediated migration and invasion of CNE-2 cells via upregulating JAM-A. LncRNA TP73-AS1, miR-495, and JAM-A are involved in migration and invasion of NPC cells. Yes The overexpression of TP73-AS1 promoted migration and invasion of NPC cell line CNE-2. 33400379 TP73-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC cells and tissues Interaction( miR-342-3p) In Vivo Experiment//Transfection//Colony Formation Assay//Migration Assay//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//IHC//Invasion Assay LncRNA TP73-AS1 was increased in NPC cells and tissues and was associated with a poor prognosis. TP73-AS1 could directly bind with miR-342-3p. MiR-342-3p overexpression attenuated the effect of TP73-AS1 in NPC cells. Furthermore, TP73-AS1 was transferred by exosomes to promote M2 polarization of macrophages. Lastly, exosomal TP73-AS1 enhanced the motility and tube formation of macrophages. LncRNA TP73-AS1 was increased in NPC cells and tissues and was associated with a poor prognosis. Yes TP73-AS1 overexpression promoted proliferation, colony formation, and DNA synthesis of NPC cells while TP73-AS1 knockdown showed opposite roles. 35012518 TP73-AS1 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissue,cell lines Interaction[sponges miR-141-3p] qRT-PCR//Luciferase Report Assay The results showed that TP73-AS1 was up-regulated in pancreatic cancer tissue and cell lines.Therefore, TP73-AS1 positively regulated BDH2 expression by sponging miR-141. These findings suggest that TP73-AS1 serves as an oncogene and promotes the metastasis of pancreatic cancer. Moreover, TP73-AS1 could serve as a predictor and a potential drug biotarget for pancreatic cancer. High levels of TP73-AS1 were correlated with poor clinicopathological characteristics and shorter overall survival. Yes The knockdown of TP73-AS1 significantly inhibited the migration and invasion of pancreatic cancer cells, while the miR-141 inhibitor significantly restored the migration and invasion. 30643007 TP73-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell line Interaction(miRNA-128-3p/GOLM1 axis) qRT-PCR//Western Blot//RIP//Transwell Assay The expression of TP73-AS1 and miRNA-128-3p was dysregulated in PC tissues and cells. Yes P73-AS1 silencing inhibited PC cell proliferation, migration, and invasion in vitro as well as suppressed tumor growth in vivo. 34007135 TP73-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LAD tissues and cell lines Interaction[PI3K/AKT pathway] IHC//Western Blot//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay In the present study, we first found that TP73-AS1 expression was markedly increased in LAD tissues and cell lines and its overexpression was strongly associated with poor clinical outcomes. Then the loss/gain-of-function assays elucidated that TP73-AS1 contributed to cell proliferation, migration, and invasion in vitro, and the in vivo experiments illustrated that its knockdown inhibited tumor growth and metastasis. Yes Then the loss/gain-of-function assays elucidated that TP73-AS1 contributed to cell proliferation, migration, and invasion in vitro, and the in vivo experiments illustrated that its knockdown inhibited tumor growth and metastasis. 30541897 TP73-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Interaction(miR-125a-3p/ACTN4) In Vivo Experiment//FISH//Transwell Assay//qRT-PCR Bioinformatics and molecular mechanism assays demonstrated that TP73-AS1 could bind to miR-125a-3p/ACTN4 and regulate their expression. Moreover, the rescued-function experiment demonstrated that suppressing miR-125a-3p or elevating ACTN4 turned around the suppression effect of sh-TP73-AS1 on NSCLC progression. Yes Knockdown of TP73-AS1 suppressed the growth and simultaneously attenuated the migration and invasion ability of NSCLC SPC-A1 and A549 cells. TP73-AS1 inhibition could also inhibit the NSCLC tumor growth and correspondingly regulated the expression of miR-125a-3p and ACTN4 in the tumor xenograft model. 36118078 TP73-AS1 LncRNA Homo sapiens Cholangiocarcinoma CCA tissue samples and cell lines Expression[highly expressed] qRT-PCR The results illustrated that TP73-AS1 transcription is enhanced in both CCA tissue samples and cell lines, and this upregulation is closely associated with larger tumor size (p=0.008) and advanced TNM stage (p=0.026) in patients with CCA. The results illustrated that TP73-AS1 transcription is enhanced in both CCA tissue samples and cell lines, and this upregulation is closely associated with larger tumor size (p=0.008) and advanced TNM stage (p=0.026) in patients with CCA. Yes For the part of functional assays, silencing of TP73-AS1 could attenuate CCA cell growth both in vitro and in vivo. 29966969 TP73-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Regulation[miR-490-3p/TWIST1 axis] qRT-PCR//Luciferase Report Assay//RIP//Western Blot In this study, we found that long non-coding RNA TP73 antisense RNA 1 (TP73-AS1) was upregulated in VM positive TNBC tissues. Furthermore, TWIST1 was a target of miR-490-3p and participated in TP73-AS1/miR-490-3p-modulated MDA-MB-231 cell VM formation. Yes Knockdown of TP73-AS1 suppressed TNBC cell line MDA-MB-231 cell VM formation in vitro. 30193732 TP73-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines interaction[ miR-142] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In thye present study, TP73-AS1 expression was significantly increased in OS tissues and cell lines. Furthermore, we identified that miR-142 could act as a direct target for TP73-AS1 and miR-142 inhibition reversed the suppression of OS cells proliferation and invasion induced by TP73-AS1 knockdown. High TP73-AS1 expression was associated with poor overall survival of OS patients. Yes TP73-AS1 knockdown suppressed OS cells proliferation and invasion in vitro as well as tumor growth in vivo. 29864904 TP73-AS1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and ovarian cancer cells Regulation[MMP2 and MMP9] CCK8//qRT-PCR//Western Blot TP73-AS1 was upregulated in the ovarian cancer tissues and ovarian cancer cells, and upregulation of TP73-AS1 was associated with poor prognosis. Tumor metastasis RT2 profiler polymerase chain reaction array showed that MMP2 and MMP9 was significantly upregulated by TP73-AS1 overexpression in ovarian cancer cells. TP73-AS1 overexpression enhanced the expression of MMP2 and MMP9 in ovarian cancer cells. TP73-AS1 was upregulated in the ovarian cancer tissues and ovarian cancer cells, and upregulation of TP73-AS1 was associated with poor prognosis. Yes Knockdown of TP73-AS1 significantly suppressed cell proliferation, invasion, and migration of SKOV3 cells, and overexpression of TP73-AS1 promoted cell proliferation, invasion, and migration of OVCA429 cells. In addition, knockdown of TP73-AS1 suppressed the in vivo tumor growth. 29904939 TP73-AS1 LncRNA Homo sapiens Retinoblastoma Rb tissues Interaction[down-regulates miR-139-3p] qRT-PCR In the present study, we found that TP73-AS1 was up-regulated, while miR-139-3p was down-regulated in Rb.miR-139-3p overexpression played an opposite role and attenuated the effects of TP73-AS1 overexpression. Therefore, lncRNA TP73-AS1 may down-regulate miR-139-3p to promote Rb cell proliferation. Yes In cells of Rb cell lines, overexpression of miR-139-3p failed to affect TP73-AS1, while TP73-AS1 overexpression caused the down-regulated miR-139-3p TP73-AS1 overexpression caused promoted proliferation of Rb cells but showed no significant effects on cell migration and invasion. 31015368 TP73-AS1 LncRNA Homo sapiens Stomach Neoplasms GC patients interaction[MicroRNA-223-5p] qRT-PCR//Luciferase Report Assay//Transwell Assay We found that miR-223-5p was upregulated and TP73-AS1 was downregulated in GC and they were inversely correlated.Therefore, miR-223-5p may target TP73-AS1 to promote the invasion and migration of gastric cancer patients. Altered miR-223-5p and TP73-AS1 expression predicted poor disease-specific survival. Yes Cell invasion and migration assays showed that miR-223-5p could promote the invasion and migration of gastric cancer cells, while TP73-AS1 could inhibit the invasion and migration of gastric cancer cells. 32248369 TPT1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and cancer tissues Regulation(CDK2) qRT-PCR It was found that TPT1-AS1 was downregulated in HCC and inversely correlated with CDK2. The expression of TPT1-AS1 in HCC tissues was not affected by age, sex, AFP, HBV, HCV, and cirrhosis infection but was downregulated by clinical stages. In HCC cells, overexpression of TPT1-AS1 mediated the downregulation of CDK2, while silencing of TPT1-AS1 mediated the upregulation of CDK2. The expression of TPT1-AS1 in HCC tissues was not affected by age, sex, AFP, HBV, HCV, and cirrhosis infection but was downregulated by clinical stages. Yes In cell proliferation assay, overexpression of TPT1-AS1 mediated the decreased proliferation rates, while silencing of TPT1-AS1 mediated the increased proliferation rates of HCC cells, while overexpression of CDK2 played an opposite role. 35377976 TPT1-AS1 LncRNA Homo sapiens Glioblastoma GBM tissues interaction[Sponges miR-23a-5p] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay The authors found miR-23a-5p was downregulated in GBM and TPT1-AS1 was upregulated in GBM, whereas the expression of these two was not significantly correlated. TPT1-AS1 may sponge miR-23a-5p in GBM to promote cancer cell proliferation by upregulating ECM1. Yes In cell proliferation assay, overexpression of TPT1-AS1 and ECM1 resulted in increased proliferation rate of GBM cells. 32783743 TPT1-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PDAC tissues and cells Interaction(ITGB3/STAT3) Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//EdU Staining LncRNA TPT1-AS1 was highly expressed in PDAC, and high TPT1-AS1 levels predicted a poor prognosis. Mechanistically, TPT1-AS1 functioned as an endogenous sponge for miR-30a-5p, which increased integrin β3 (ITGB3) level in pancreatic cancer cells. Conversely, our data revealed that ITGB3 could activate the transcription factor signal transducer and activator of transcription 3 (STAT3), which in turn bound directly to the TPT1-AS1 promoter and affected the expression of TPT1-AS1, thus forming a positive feedback loop with TPT1-AS1. LncRNA TPT1-AS1 was highly expressed in PDAC, and high TPT1-AS1 levels predicted a poor prognosis. Yes Moreover, functional experiments revealed that TPT1-AS1 promoted pancreatic cancer cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) process in vitro and in vivo. 35534983 circGFRA1 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(miR-1228) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay CircGFRA1 was remarkably upregulated in HER-2-positive BC. Through ceRNA mechanism, circGFRA1 could bind to miR-1228 and alleviate inhibitory activity of miR-1228 on targeted gene AIFM2. Yes Knockdown of circGFRA1 could attenuate HER-2-positive BC progression by inhibiting the proliferation, infiltration and migratory ability of HER-2-positive BC cells. 34668628 circARL3 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(miR-1305) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//FISH//Luciferase Report Assay In this study, we performed circRNA microarray profile and found an HBV-related circRNA, circ-ARL3 (hsa_circ_0092493). In terms of mechanism, HBx protein upregulated N+6 -methyladenosine (m6 A) methyltransferases METTL3 expression, increasing the m6 A modification of circ-ARL3; then, m6 A reader YTHDC1 bound to m6 A-modified of circ-ARL3 and favored its reverse splicing and biogenesis. Furthermore, circ-ARL3 was able to sponge miR-1305, antagonizing the inhibitory effects of miR-1305 on a cohort of target oncogenes, thereby promoting HBV HCC progression. High circ-ARL3 was positively correlated with malignant clinical features and poor prognosis. Yes Stable knockdown of circ-ARL3 inhibited the proliferation and invasion of HBV HCC cells. 33372396 hsa_circ_0051488 CircRNA Homo sapiens Pulmonary Squamous Cell Carcinoma Interaction(mir-6717-5p) Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//CCK8//qRT-PCR//RNA-seq//Luciferase Report Assay//Colony Formation Assay//Invasion Assay The well-established model of transformed cells provided an ideal platform for analyzing the molecular characteristics of this circRNA in the malignant transformation of lung epithelial cell, which supports that hsa_circ_0051488 functions in the onset and growth of lung squamous cell carcinoma (LUSC). In particular, hsa_circ_0051488 binds to mir-6717-5p, thereby modulating the expression of SATB2 gene, a lung cancer suppressor. Yes Further analysis indicates that the absence of hsa_circ_0051488 promoted the proliferation of cells with the malignant phenotype. Extensive experiments confirm that hsa_circ_0051488 is present in the cytoplasm and functioned as a competing endogenous RNA. 34320692 TP73-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Regulation[miR-194-5p/SDAD1 axis] qRT-PCR//Luciferase Report Assay TP73-AS1 was upregulated in GC tissues and cell lines.TP73-AS1 accelerates tumor progression in gastric cancer through regulating miR-194-5p/SDAD1 axis. Yes Furthermore, TP73-AS1 exerted oncogenic role in GC through promoting cell growth and metastasis. 30279010 TP73-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Regulation[WNT/β-catenin signaling pathway] CCK8//qRT-PCR//Western Blot//Transwell Assay Reverse transcription-quantitative polymerase chain reaction analysis demonstrated that TP73-AS1 was significantly upregulated in GC tissues compared with adjacent normal tissues. In addition, the downregulation of TP73-AS1 suppressed the expression of transcription factor 4 and β-catenin, which suggested that a decrease in TP73-AS1 suppressed the WNT/β-catenin signaling pathway in GC. The higher expression of TP73-AS1 was closely associated with lymph node metastasis and tumor-node-metastasis stage in patients with GC. Those patients with GC showing a higher expression of TP73-AS1 were predicted to have shorter disease-free survival and overall survival rates. Yes The knockdown of TP73-AS1 was shown to markedly inhibit cell proliferation, cell colony formation and cell invasion. 30127921 TP73-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-27b-3p/TMED5 axis) Western Blot//Colony Formation Assay//CCK8//qRT-PCR//FISH//IHC//Transwell Assay TP73-AS1 over-expressed in GC. Meanwhile, miR-27b-3p was a negative correlation with TP73-AS1 and TMED5. The TP73-AS1/miR-27b-3p/TMED5 axis regulate wnt/β-catenin pathway. Yes Suppressed TP73-AS1 inhibited cell proliferation, migration, and invasion. However, down-regulated miR-27b-3p could reverse the effects of weakenTP73-AS1 on the progression of GC. Moreover, TMED5 was also up-regulated in GC. Both TP73-AS1 and TMED5 were the direct target of miR-27b-3p. 35281863 TP73-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[TGF-β1 signaling] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//ELISA We found TP73-AS1 and MMP-8 upregulation, and miR-539 downregulation in HCC tissues and cell lines. Our study demonstrated lncRNA TP73-AS1 negatively regulated miR-539 to promote MMP-8 expression, which activated TGF-β1 signaling to induce M2 macrophage polarization in HCC. Lower TP73-AS1 and MMP-8 expressions and higher miR-539 expression were associated with higher survival rate of patients. Yes We also found knockdown of TP73-AS1 or overexpression of miR-539 inhibited HCC tumor growth and M2 macrophage infiltration in vivo. 32818670 TP73-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines regulation[miRNA-125a-3p/metadherin axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Expression of TP73-AS1 was higher in breast cancer tissues and cell lines.Knockdown of TP73-AS1 inhibited cell proliferation, migration and invasion, but facilitated apoptosis in breast cancer cells in vitro through targeting miR-125a and upregulating MTDH, suggesting a novel TP73-AS1/miR-125a/MTDH pathway in the malignant progression of breast cancer. Yes Biologically, its knockdown could promote cell apoptosis rate, and inhibit proliferative capacity, migration and invasion ability in HCC-70 and MB231 cells, accompanied with higher cleaved caspase 3 level and lower Ki67, N-cadherin and Vimentin level. 31901156 TP73-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and adjascent non-cancer tissues Expression[highly expressed] qRT-PCR//Transwell Assay It was found that expression levels of TP73-AS1 in NSCLC tissues were significantly upregulated comparing to adjacent non-cancer tissues We found that TP73-AS1 was upregulated in tumor tissues than in non-tumor tissues of NSCLC patients, and high expression levels of TP73-AS1 predicted poor survival. Yes TP73-AS1 and miR-21 overexpression caused the accelerated invasion and migration of NSCLC cells. However, TP73-AS1 overexpression failed to affect cell proliferation. 31129247 TP73-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction[miR-141-3p] BrdU//qRT-PCR//Luciferase Report Assay TP73-AS1 was upregulated in NSCLC tissues and cell lines.In NSCLC tissues, miR-141-3p was down-regulated; TP73-AS1 was inversely correlated with miR-141-3p. Yes However, when knockdown of TP73-AS1 inhibited the NSCLC proliferation. 31749884 TP73-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cells regulation[miR-27b-3p/LAPTM4B Axis] qRT-PCR//MTT//Luciferase Report Assay//Western Blot We found that TP73-AS1 was strikingly up-regulated in lung cancer tissues and cells.TP73-AS1 promoted the progression of lung cancer through regulating miR-27b-3p/LAPTM4B axis and it might be a potential target for diagnosis and treatment of lung cancer. Yes TP73-AS1 depletion inhibited the growth and metastasis of lung cancer cells in vitro. 32764992 TP73-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and CRC cell lines interaction[miR-194,TGFα] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay TP73-AS1 was up-regulated in both CRC tissues and CRC cell lines. this study demonstrated that TP73-AS1 regulated CRC progression by acting as a competitive endogenous RNA to sponge miR-194 to modulate the expression of TGFα. Overexpression of TP73-AS1 was associated with metastasis and advanced clinical stages in CRC patients. Yes Overexpression of TP73-AS1 promoted CRC cell growth, proliferation, migration and invasion in vitro; and knockdown of TP73-AS1 significantly inhibited CRC cell growth, proliferation, migration and invasion in vitro as well as tumor growth in vivo. 30010111 TP73-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues ,cell lines Interaction[miR‑103] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay We found that TP73‑AS1 expression was significantly low in CRC tissues and cells.Furthermore, TP73‑AS1 expression levels were positively associated with PTEN levels in clinical CRC samples. As expected, TP73‑AS1 could upregulate PTEN expression in CRC cells. Mechanistically, PTEN was shown to be the target of miR‑103. Interestingly, TP73‑AS1 overexpression could increase PTEN expression through competitive binding to miR‑103. Functionally, our data show that such TP73‑AS1-induced PTEN expression through binding to miR‑103 facilitated CRC cell proliferation. We found that TP73‑AS1 expression was significantly low in CRC tissues and cells, and high TP73‑AS1 expression was negatively associated with TNM stage, prognosis, overall survival, and disease-free survival in the CRC patients. Yes Moreover, TP73‑AS1 overexpression dramatically inhibited CRC cell growth, promoted apoptosis, downregulated Bcl‑2 levels, and increased caspase‑3 expression. 30472379 TP73-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[TGF-β1] qRT-PCR//Western Blot In the present study, we found that TP73-AS1 was upregulated in CRC tissues compared with adjacent non-CRC tissues in CRC patients. Therefore, TP73-AS1 may inactivate TGF-β1 to inhibit the migration and invasion of CRC cells. Yes TP73-AS1 and TGF-β1 overexpressions caused enhanced migration and invasion of CRC cells. 31908524 TP73-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC samples and cell lines Interaction(KDM5A/TP73 ) FISH//RIP//IP//ChIP We found that TP73-AS1 was highly expressed in malignant CRC samples in The Cancer Genome Atlas (TCGA) database. We also demonstrated TP73-AS1 was expressed in thirty samples of CRC tissues collected from China Medical University patients as well as in HCT116, RKO and SW480 CRC cell lines but not in HCoEpiC or CCD-18Co normal colon cells. In addition, an interaction between lysine demethylase 5A (KDM5A) and TP73-AS1 in CRC cells, but not normal colon cells, and KDM5A localization on the TP73 promoter were influenced by TP73-AS1. Interestingly, the H3K4me3 level on the TP73 promoter was reduced, but was elevated by TP73-AS1 knockdown in CRC cells. Yes Only wild-type TP73-AS1, but not any of its alternate splicing isoforms, was positively correlated with tumor malignancy. TP73-AS1 transcripts were shown to be located in cell nuclei especially in close proximity to the TP73 promoter in CRC cells, but not in normal colon cells. 35896939 TP73-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer cells Expression(highly expressed) Wound Healing Assay//Flow Cytometry//qRT-PCR//Cell Cycle Assay//Colony Formation Assay Results indicated that TP73-AS1 was upregulated whereas TP73 was downregulated in prostate cancer cells compared to normal prostate cells and there was a negative correlation between them. Yes Besides, loss of function experiments of TP73-AS1 in prostate cancer cells strongly induced cellular apoptosis, interfered with the cell cycle progression, and modulated related pro- and anti-apoptotic gene expression. Colony formation and migration capacities of TP73-AS1-silenced prostate cancer cells were also found to be dramatically reduced. 35138524 TP73-AS1 LncRNA Homo sapiens Lymphoma, Extranodal NK-T-Cell NKTCL patients Regulation(DKK1 methylation) Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay TP73-AS1 level was higher in peripheral blood of NKTCL patients than that of healthy volunteers. TP73-AS1 induced methylation of DKK1 promoter through DNMT1/DNMT3, thus regulating NKTCL cell functions. Yes Knockdown of TP73-AS1 in vitro weakened proliferative and migratory functions of NKTCL cells. 34565015 TPT1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CSCs Interaction(STAT1/Wnt/β-catenin ) qRT-PCR//Western Blot//RIP//FISH TPT1-AS1 was identified as a significantly upregulated gene in CRC using the GSE146587 dataset. TPT1-AS1 was significantly highly expressed in the CSCs compared to non-stem cells. TPT1-AS1 recruited STAT1 to the promoter region of APC to suppress APC transcription. Further upregulation of STAT1 or downregulation of APC blocked the role of TPT1-AS1 silencing and restored the malignant behaviors of CSC stem cells. APC inactivated the Wnt/β-catenin pathway. Yes Downregulation of TPT1-AS1 reduced the stemness of the CRC stem cells. 35022996 TNFRSF10A-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction( miR-3121-3p/HuR) qRT-PCR//Western Blot//Transwell Assay TNFRSF10A-AS1 was expressed at a high level in CRC and the upregulation of TNFRSF10A-AS1 was associated with advanced T grade and tumor size in CRC patients. A mechanistic analysis demonstrated that TNFRSF10A-AS1 acted as a miR-3121-3p molecular sponge to regulate HuR expression, ultimately promoting colorectal tumorigenesis and progression. TNFRSF10A-AS1 was expressed at a high level in CRC and the upregulation of TNFRSF10A-AS1 was associated with advanced T grade and tumor size in CRC patients. Yes TNFRSF10A-AS1 was expressed at a high level in CRC and the upregulation of TNFRSF10A-AS1 was associated with advanced T grade and tumor size in CRC patients. 35721888 TOB1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma esophageal cancer cells and ESCC tissues Epigenetics(hypermethylation) Western Blot//qRT-PCR//RIP//IHC//ChIP Frequent down-regulation of TOB1-AS1 and TOB1 was verified in esophageal cancer cells and ESCC tissues, and there was a positive correlation between them in ESCC tissues. The CpG sites hypermethylation within proximal promoter of TOB1-AS1 and TOB1 could lead to transcriptional inhibition of both genes. Furthermore, expression and proximal promoter methylation status of TOB1-AS1 or TOB1 may be associated with ESCC patients' prognosis. Up-regulation of TOB1-AS1 increased expression level of TOB1, and TOB1-AS1 could work as a ceRNA to modulate ATF3 expression via competitively binding with miR-103a-2-5p. Meanwhile, ATF3, as a transcription factor, could regulate transcription of TOB1; down-regulation of TOB1-AS1 in ESCC led to decreased expression of ATF3 through ceRNA mechanism, and further influenced the transcription of TOB1. Yes TOB1-AS1 and TOB1 may function as tumor suppressors by inhibiting growth, migration, and invasion of esophageal cancer cells. 36002674 hsa_circ_0005795 CircRNA Homo sapiens Basal cell carcinoma, multiple Nodular BCC and adjacent non-tumor tissues derived from 30 patients and 2 BCC cell lines Interaction(miR-1231) Transfection//Immunoblotting//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Circ_0005795 expression was significantly elevated in BCC tissues and cells. Yes Knockdown of Circ_0005795 dramatically reduced cell viability, colony formation, and anti-apoptotic protein levels, while increased caspase-3 activity. Circ_0005795 located in cytoplasm, which exerted its tumor-promoting effect through targeting and sponging miR-1231 in BCC cells. 33433717 TNK2-AS1 LncRNA Homo sapiens Stomach Neoplasms  GC tumor and cell lines Interaction(miR-125a-5p) Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay//IF The results showed that TNK2 AS1 overexpression promoted the malignant behaviors of AGS cells, which could be weakened by miR-125a-5p mimic addition. In addition, Jumonji, At-rich interaction domain (JARID2), and phosphatidylinositol 3 kinase (PI3K)/AKT pathway were regulated by TNK2-AS1/miR-125a-5p axis. Yes In vivo, TNK2 AS1/miR-125a-5p axis promoted tumor growth and led to increases in green fluorescence intensity and vimentin expression and a decrease in E-cadherin level, which could be mediated by JARID2 and PI3K/AKT pathway. 34494305 TNK2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC samples Regulation[STAT3/VEGFA signaling] Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay TNK2-AS1 was significantly upregulated in NSCLC and correlated with poor prognosis. Collectively, our work has elucidated a novel mechanism of TNK2-AS1-mediated angiogenesis by enforcing STAT3/VEGFA signaling and may provide a potential target for therapeutic intervention. TNK2-AS1 was significantly upregulated in NSCLC and correlated with poor prognosis. Yes We found that TNK2-AS1 could increase viability and migration of NSCLC cells in vitro. 30454892 TNK2-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML cell lines Interaction(EZH2/CELF2/PI3K/Akt pathway) CCK8//qRT-PCR//Western Blot TNK2-AS1 expression was upregulated in AML cell lines and negatively correlated with survival patients.Mechanistically, the upregulation of TNK2-AS1 was activated by transcription factor ELK1. We also uncovered that TNK2-AS1 exerted tumor-promoting effect through silencing CELF2 via binding with EZH2, thus activating PI3K/Akt pathway in AML cells. Elevated expression of TNK2-AS1 was induced by ELK1 and facilitated AML progression by suppressing CELF2 expression via EZH2-mediated epigenetic silencing, suggesting TNK2-AS1 may be a promising therapeutic target and prognostic marker for AML patients. TNK2-AS1 expression was upregulated in AML cell lines and negatively correlated with survival patients. Yes Knockdown of TNK2-AS1 markedly reduced AML cell proliferation and promoted apoptosis and differentiation. Likewise, TNK2-AS1 knockdown significantly suppressed tumor growth in vivo. 35941836 TNFRSF10A-DT LncRNA Homo sapiens Adenocarcinoma of Lung tumor tissues and cell lines regulation[EGFR/MET signaling] qRT-PCR//Colony Formation Assay//Western Blot We found that LOC389641 was highly expressed in lung adenocarcinomas and was associated with poor patient survival. Mechanistically, downregulation of LOC389641 was found to decrease EGFR, MET and STAT3 proteins expression in lung cancer cells. We found that LOC389641 was highly expressed in lung adenocarcinomas and was associated with poor patient survival. Yes Silencing of LOC389641 reduced colony formation, cell proliferation and invasion, as well as induced autophagy and apoptosis of lung adenocarcinoma cell lines in vitro. 33318313 TNFRSF10A-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Interaction(MPZL1) FISH//RNA Pull-Down//RNA-seq T-AS1 was upregulated in GC cell lines and GC tissues as compared to adjacent non-cancer tissues (n = 47, P < 0.001). Mechanistically, T-AS1 directly bound to Myelin Protein Zero Like 1 (MPZL1). MPZL1 showed an oncogenic function in GC by promoting cell proliferation, migration and invasion but inhibiting cell apoptosis. High expression of MPZL1 was associated with poor survivor of GC patients. Knockdown of MPZL1 could abrogate the effect of T-AS1 in the tumor-promoting function. Yes Multivariate analysis showed that GC patients with T-AS1 high expression had a significantly shortened survival (n=103, P < 0.05). T-AS1 significantly promoted GC cell proliferation, cell-cycle progression, and cell migration/invasion abilities, but suppressed cell apoptosis. Silencing of T-AS1 in GC cells exerted opposite effects in vitro. Knockout of T-AS1 significantly inhibited xenograft tumor growth in nude mice. 35637954 TMPOP2 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Interaction[HPV16/18 E6/E7] Western Blot//qRT-PCR//RNA-seq//Luciferase Report Assay//EdU Staining We also observed a higher RNA level of TMPOP2 in HeLa cervical cancer cells than in nonmalignant HaCaT cells (Fig. 1A). Together, our results indicate that TMPOP2 and HPV16/18 E6/E7 mutually strengthen their expression in cervical cancer cells to enhance tumorigenic activities. Yes Moreover, results of RNA sequencing and cell cycle analysis showed that knockdown of TMPOP2 impaired the expression of cell cycle genes, induced cell cycle arrest, and inhibited HeLa cell proliferation. 30728257 TONSL-AS1 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tumor tissues regulation[miR-490-3p/CDK1 ] CCK8//qRT-PCR//Western Blot We observed that TONSL-AS1 was upregulated in EOC tumor tissues from EOC patients, and its high expression level was correlated with poor survival. Therefore, TONSL-AS1 may regulate miR-490-3p/CDK1 to affect EOC cell proliferation. We observed that TONSL-AS1 was upregulated in EOC tumor tissues from EOC patients, and its high expression level was correlated with poor survival. Yes Overexpression of TONSL-AS1 and CDK1 resulted in increased proliferation rate of EOC cells. 32414422 TMPO-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[miR-140-5p/SOX4 axis] qRT-PCR//Luciferase Report Assay We observed that TMPO-AS1 was up-regulated in GC tissues, and high TMPO-AS1 expression in GC patients was closely correlated with aggressive clinicopathologic characteristics and poor overall survival.Our findings indicated that TMPO-AS1 promotes GC progression partly by regulating miR-140-5p/SOX4 axis, and may serve as a novel therapeutic target for GC. We observed that TMPO-AS1 was up-regulated in GC tissues, and high TMPO-AS1 expression in GC patients was closely correlated with aggressive clinicopathologic characteristics and poor overall survival. Yes Functionally, gain- and loss-of-function studies showed that TMPO-AS1 overexpression enhanced the proliferation, migration, invasion and EMT of GC cells in vitro, whereas knockdown of TMPO-AS1 inhibited these malignant traits. 32110100 TMPO-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-126-5p/BRCC3 axis/PI3K/Akt/mTOR pathway) RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay TMPO-AS1 was highly expressed in GC tissues and cells. Furthermore, it was found that TMPO-AS1 acted as a competing endogenous RNA for miR-126-5p to upregulate BRCC3 expression. Rescue assays revealed that TMPO-AS1 facilitated cellular progression of GC by sponging miR-126-5p and upregulating BRCC3. In addition, we found that the effects of the TMPO-AS1/miR-126-5p/BRCC3 axis on GC cell progression were related to the PI3K/Akt/mTOR pathway. Upregulated TMPO-AS1 was closely associated with adverse prognosis of GC patients. Yes Functional assays showed that TMPO-AS1 promoted GC cell proliferation, migration, and angiogenesis. 33295056 TMPO-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines interaction[ sponging miR-140-5p] qRT-PCR//Luciferase Report Assay TMPO-AS1 expression levels were significantly increased in breast cancer tissues and cell lines compared with adjacent non-cancerous tissues and MCF-10A cells, respectively. Mechanistically, TMPO-AS1 promoted cellular viability and migration as a competing endogenous RNA by sponging miR-140-5p. Yes In vitro and in vivo studies indicated that TMPO-AS1 knockdown significantly suppressed breast cancer cell viability at 48 and 72 h compared with the small interfering (si)RNA negative control group (NC; siNC). TMPO-AS1 knockdown in vitro inhibited MCF-7 and T47D cell migration and invasion compared with the siNC group. 33235626 TMPO-AS1 LncRNA Homo sapiens Breast Neoplasms TNBC cell lines Expression[highly expressed] qRT-PCR//Cell Cycle Assay We here showed that TMPO-AS1 is abundantly expressed in basal-like breast cancer subtype based on the transcriptomic data in The Cancer Genome Atlas as well as in TNBC cell lines and patient-derived cells. Yes Small interfering RNA-based loss-of-function analyses showed that TMPO-AS1 knockdown substantially represses the proliferation and migration of TNBC cells. 32437068 TMPO-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells Interaction(miR-4731-5p/FOXM1 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Transwell Assay In the BC tissues and cells, TMPO-AS1 was significantly increased (P<0.05). Mechanically, TMPO-AS1 negatively regulates miR-4731-5p and influences the progression of BC through the miR-4731-5p/FOXM1 axis. Yes Functional studies suggest that the knockdown of TMPO-AS1 tremendously restrains tumor cell growth and migration (P<0.05). 34786045 TMPO-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[ERBB2, miR-204-3p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay We demonstrated that TMPO-AS1 was significantly up-regulated in cancerous tissues of NSCLC samples, and positively correlated with the expression of ERBB2, while negatively correlated with miR-204-3p. Collectively, we conclude that TMPO-AS1 has the potential to be the 'ceRNA' to regulate the expression of ERBB2 by sponging miR-204-3p in NSCLC. Yes After transfection of TMPO-AS1 shRNAs into NSCLC cells, the malignant phenotypes of NSCLC cells were significantly inhibited, while overexpression of TMPO-AS1 had opposite effects; TMPO-AS1 was also demonstrated to regulate the expression of miR-204-3p by sponging it, and indirectly modulate the expression of ERBB2. 32969763 TMPO-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tumor samples and cells Interaction(FUS/TMPO ) RNA Pull-Down//RIP//ChIP TMPO-AS1 expression was significantly upregulated in ESCC tumor samples, with higher TMPO-AS1 expression positively correlated with shorter overall survival times. Mechanistically, TMPO-AS1 bound to fused in sarcoma (FUS) and recruited p300 to the TMPO promoter, forming biomolecular condensates in situ to activate TMPO transcription in cis by increasing the acetylation of histone H3 lysine 27 (H3K27ac). TMPO-AS1 expression was significantly upregulated in ESCC tumor samples, with higher TMPO-AS1 expression positively correlated with shorter overall survival times. Yes In vitro and in vivo functional experiments revealed that TMPO-AS1 promotes the proliferation and metastasis of ESCC cells. Targeting TMPO-AS1 led to impaired ESCC tumor growth in a patient-derived xenograft (PDX) model. 35760875 TOB1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Regulation[TOB1-AS1/miR-23a/NEU1 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The levels of TOB1-AS1 were decreased in GC tissues and cell lines. Further, the role of TOB1-AS1 silencing on cell behaviors was abrogated by NEU1 upregulation. TOB1-AS1 and NEU1 exerted their roles via Wnt/b-catenin signaling pathway.Mechanically, miR-23a was targeted by TOB1-AS1, but directly targeted NEU1. Yes Either TOB1-AS1 or NEU1 upregulation accelerated GC cell apoptosis, hampered proliferation, migration, and invasion.Overexpression of TOB1-AS1 blocked GC development in vivo. 31799657 TONSL-AS1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and paired adjacent normal tissues Interaction(MicroRNA-135a ) Transfection//Proliferation Assay//RIP//Survival Analysis//PCR//Cell Proliferation Assay//IP//IF The results demonstrated that TONSL-AS1 expression was downregulated in HCC tissues, which was associated with a lower survival rate in patients with HCC. TONSL-AS1 and miR-135a were predicted to interact with each other, whereby overexpression of miR-135a downregulated TONSL-AS1 expression. he results demonstrated that TONSL-AS1 expression was downregulated in HCC tissues, which was associated with a lower survival rate in patients with HCC. Yes  Notably, overexpression of TONSL-AS1 inhibited HCC cell proliferation, while overexpression of miR-135a promoted HCC cell proliferation and decreased the effect of overexpression of TONSL-AS1 on cell proliferation.  34630715 TP73-AS1 LncRNA Homo sapiens Stomach Neoplasms EBVaGC cells Regulation(PRC2/WIF1 ) In Vivo Experiment//IHC//ChIP//Western Blot//Transfection//Wound Healing Assay//CCK8//RIP//qRT-PCR//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay TP73-AS1 was increased while WIF1 was decreased in EBVaGC cells. TP73-AS1 promoted the binding of EZH2 to the WIF1 promoter by directly binding to EZH2, and thus inhibiting the expression of WIF1 by enhancing H3K27me3 level of WIF1 promoter. Moreover, TP73-AS1 activated Wnt/β-catenin signaling pathway and promoted EMT by down-regulating WIF1. Yes Silencing of TP73-AS1 or overexpression of WIF1 repressed the growth and migration while promoted apoptosis of EBVaGC cells. Knockdown of WIF1 reversed the anticancer effect of TP73-AS1 silencing. TP73-AS1 silencing inhibited the progression of EBVaGC in nude mice by epigenetically regulating WIF1. 34314802 TP53TG1 LncRNA Homo sapiens Retinoblastoma RB tissues and cell lines Interaction(miR-33b) In Vivo Experiment//Western Blot//qPCR//CCK8//Luciferase Report Assay//EdU Staining Here, we revealed a large expression of TP53TG1 in RB tissues and cell lines. Yes Conversely, we showed marked suppression of cell proliferation, migration, and invasion in TP53TG1 knocked down RB cells. Mechanistically, we established that TP53TG1 directly interacted with microRNA (miR)-33b in RB cells 34247545 TP53TG1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(CIP2A/PI3K/AKT pathway) Western Blot//FISH//RIP//qRT-PCR//IHC In addition, low TP53TG1 expression was significantly associated with poor survival in patients with GC. m6A modification sites are highly abundant on TP53TG1, and demethylase ALKBH5 reduces TP53TG1 stability and downregulates its expression. TP53TG1 interacts with cancerous inhibitor of protein phosphatase 2A (CIP2A) and triggers its ubiquitination-mediated degradation, resulting in the inhibition of the PI3K/AKT pathway. In addition, low TP53TG1 expression was significantly associated with poor survival in patients with GC. Yes TP53TG1 inhibited the proliferation, metastasis, and cell cycle progression of GC cells, while it promoted their apoptosis. 36114757 TP53TG1 LncRNA Homo sapiens Carcinoma, Hepatocellular Regulation CCK8//qRT-PCR//Western Blot//Migration Assay We found that the knockdown of TP53 in HCC cells caused the upregulation of TP53TG1. Furthermore, we found that the knockdown of TP53TG1 not only suppressed HCC cell proliferation and migration, but also reduced intrinsic ERK signaling. In contrast, the overexpression of TP53TG1 increased ERK activation and enhanced HCC proliferation. Yes We found that the knockdown of TP53 in HCC cells caused the upregulation of TP53TG1. In contrast, the overexpression of TP53TG1 increased ERK activation and enhanced HCC proliferation. 34564314 TP53TG1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(PRDX4/β-catenin pathway) qRT-PCR//IHC//RNA Pull-Down//RIP The expression of lncRNA-TP53TG1 was significantly decreased in HCC tissues and cells. Mechanistically, lncRNA-TP53TG1 physically interacted with PRDX4 and promoted its ubiquitin-mediated degradation, resulting in the inactivation of the WNT/β-catenin signaling pathway in hepatoma cells. Decreased expression of lncRNA-TP53TG1 was associated with aggressive clinical phenotypes and a poor prognosis. Yes Ectopic expression of lncRNA-TP53TG1 inhibited hepatoma cell proliferation and migration in vitro and in vivo, whereas lncRNA-TP53TG1 knockdown exerted the opposite effects. Furthermore, lncRNA-TP53TG1 played an important role in slowing the epithelial-mesenchymal transition (EMT) process in HCC. 33957185 TP53TG1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues Interaction[sponge of microRNA-96 ] Western Blot//ISH//CCK8//qRT-PCR//RIP//Luciferase Report Assay In our studies, we identified that TP53TG1 was highly expressed in PDAC and was a novel regulator of PDAC development.Taken together, these observations imply that TP53TG1 contributes to the growth and progression of PDAC by acting as a competing endogenous RNA (ceRNA) to competitively bind to miR-96 and regulate KRAS expression, which highlights the importance of the complicated miRNA-lncRNA network in modulating the progression of PDAC. Yes Knockdown of TP53TG1 inhibited proliferation, induced apoptosis, and decreased migration and invasion in PDAC cells, whereas enhanced expression of TP53TG1 had the opposite effects. 31325400 TP53TG1 LncRNA Homo sapiens Uterine Cervical Neoplasms HeLa cells Regulation Cell Proliferation Assay//Bioinformatics Analysis//RNA-seq//Cell Apoptosis Assay We found that TP53TG1 overexpression significantly inhibited cell proliferation and induced apoptosis, demonstrating that TP53TG1 may be a novel anti-oncogenic factor in cervical cancer. Furthermore, overexpression of TP53TG1 could activate type I interferon signaling pathways and inhibit the expression of genes involved in DNA damage responses. Yes We found that TP53TG1 overexpression significantly inhibited cell proliferation and induced apoptosis, demonstrating that TP53TG1 may be a novel anti-oncogenic factor in cervical cancer. Furthermore, overexpression of TP53TG1 could activate type I interferon signaling pathways and inhibit the expression of genes involved in DNA damage responses. 36267418 TP53TG1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells and tissues Interaction(miR-33a-5p/FOXK2/PI3K/AKT/mTOR signaling pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay TP53TG1 and FOXK2 expression levels were increased and miR-33a-5p expression level was reduced in CC cells and tissues. TP53TG1 accelerates the CC development via regulating miR-33a-5p to target FOXK2 with the involvement of PI3K/AKT/mTOR signaling pathway. Yes The silenced TP53TG1 or FOXK2, or elevated miR-33a-5p decelerated the CC cell development and restrained the activation of PI3K/AKT/mTOR signaling pathway. The depleted FOXK2 or elevated miR-33a-5p reversed the effects of decreased TP53TG1 on CC cell progression. TP53TG1 sponged miR-33a-5p, which targeted FOXK2. The experiment in vivo validated the outcomes of the experiment in vitro. 35090377 TP53TG1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Interaction[miR-383-5p/RBM3 pathway] qRT-PCR//Luciferase Report Assay In our present study, we identify LINC00096 as one of the most upregulated lncRNA in TNBC progression by using microarray screening. Mechanistically, we demonstrated that LINC00096 directly interacted with miR-383-5p, subsequently acted as a miRNA sponge to increase RBM3 expression. High LINC00096 expression was obviously related to advanced tumor stage, metastasis, poor prognosis of patients. Yes Loss-of-function assays showed that LINC00096 suppression reduced TNBC cells proliferation and invasive abilities in vitro. 31819536 TP53TG1 LncRNA Homo sapiens Idiopathic Pulmonary Fibrosis MRC-5 as well as PMLFs Interaction(MYH9) Western Blot//Wound Healing Assay//FISH//qRT-PCR//EdU Staining//IF Here, we systematically identified a crucial lncRNA, p53-induced long non-coding RNA TP53 target 1 (TP53TG1), which was the dysregulated hub gene in IPF regulatory network and one of the top degree genes and down-regulated in IPF-drived fibroblasts. Mechanistically, TP53TG1 was found to bind to amount of tight junction proteins. Importantly, we found that TP53TG1 binds to the Myosin Heavy Chain 9 (MYH9) to inhibit its protein expression and thus the MYH9-mediated activation of fibroblasts. Yes Functional experiments revealed that overexpression of TP53TG1 attenuated the increased expression of fibronectin 1 (Fn1), Collagen 1α1, Collagen 3α1, ACTA2 mRNA, Fn1, and Collagen I protein level, excessive fibroblasts proliferation, migration and differentiation induced by TGF-β1 in MRC-5 as well as PMLFs. In vivo assays identified that forced expression of TP53TG1 by adeno-associated virus 5 (AAV5) not only prevented BLM-induced experimental fibrosis but also reversed established lung fibrosis in the murine model. 35661695 TP53COR1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Expression[lower expressed] qRT-PCR We demonstrated that the expression level of lincRNA-p21 was downregulated in the GC tissues and cell lines. Yes Moreover, ectopic expression of lincRNA-p21 suppressed the GC cell growth, cell cycle, and migration.Overexpression of lincRNA-p21 inhibited the GC cell proliferation and increased the radiosensitivity of GC cells by regulating the β-catenin signaling pathway. 30484893 TONSL-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and their adjacent normal tissues,cell lines(SGC‐7901, MGC‐803) Interaction[activating TONSL] qRT-PCR//FISH//Luciferase Report Assay//Western Blot TONSL-AS1 was significantly downregulated in cancer tissues compared with paired normal tissues.SGC‐7901 and MGC‐803 had the lowest TONSL-AS1 expression levels among all cells.Mechanistically, TONSL-AS1's genomic neighboring gene TONSL, which was reported as a tumor suppress gene, was upregulated by TONSL. Yes TONSL-AS1 inhibited cell migration, invasion and proliferation in SGC-7901, MGC-803 cells. Furthermore, TONSL-AS1 could suppress cell tumorigenesis in vivo. 31158361 TP53COR1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues Interaction[p53] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results demonstrated that there was a significant low‑expression of lincRNA‑p21 in NSCLC tumor tissues, and lincRNA‑p21 effectively inhibited the progression of lung cancer cells by sExpression[Expression[up-expression]-expression]pressing cell proliferation and migration and promoting cell apoptosis. An evident negative association between lincRNA‑p21 and miR‑17‑5p expression was observed, and the inhibitory effect of overexpressed lincRNA‑p21 on lung cancer cells was counteracted by miR‑17‑5p. Bioinformatics and luciferase reporter analysis results confirmed that miR‑17‑5p is a direct target for lincRNA‑p21. The present study provides evidence for lincRNA‑p21 to inhibit the progression of NSCLC via direct targeting of a miR‑17‑5p associated signaling pathway. Yes Furthermore, the effect of lincRNA‑p21 overexpression and knockExpression[down-expression] on different NSCLC cell lines was further investigated in vitro. 30535441 TP53COR1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues ,cell lines Interaction[PUMA ] qRT-PCR//RNA Pull-Down//Microarray LincRNA-p21 was significantly upregulated in NSCLC tissues and cells. PUMA was a direct target gene of lincRNA-p21 and was negatively correlated with lincRNA-p21 in NSCLC specimens. The anti-apoptotic effect of lincRNA-p21 can be effectively attenuated by the upregulation of PUMA. Yes The upregulation of lincRNA-p21 considerably inhibited cell apoptosis while the downregulation of lincRNA-p21 showed the opposite effect. 30556447 TP53COR1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissue,cell lines Interaction[p53 signal pathway] CCK8//qRT-PCR//Western Blot LincRNA-p21 expression level was remarkably lower in tumor tissues versus nontumor tissues and lower in EC109 cells versus Het-1A cells.Then, we found that LincRNA-p21 promotes the expression of p21. Decreasing the level of p21 revealed that cell-cycle arrest was restored. Pathway analysis found p53 pathway was downregulated, and Expression[up-expression]regulation of LincRNA-p21 inhibited the expression of cyclin D. Yes The results demonstrated that Expression[up-expression]regulating the expression of LincRNA-p21 could inhibit cell proliferation, migration, invasion, and the transition of cell cycle from G1 and promoted apoptosis of EC109. 31308755 TP53COR1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Expression[lower expressed] CCK8//qRT-PCR//Western Blot Long intergenic non-coding RNA p21 (lincRNA-p21) is down-regulated in some solid tumors. Yes In the present study, we investigated the involvement of lincRNA-p21 and glutamine catabolism in BC cell growth and found that ectopic linRNA-p21 expression reduced the proliferation and growth of BIU87 and 5637 cells. Opposite results were observed in lincRNA-p21 silenced J82 and T24 cells. 30902882 TP53COR1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues Regulation[JAK2/STAT3 signaling pathway] RNA Pull-Down//Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining//ChIP Lower lincRNA-p21 expression was observed in HNSCC tissues and indicated worse prognosis. Knockdown NF-YA expression reversed tumor suppressor activation of lincRNA-p21 in mutant p53 cells, not wild-type p53 cells. A negative correlation was observed between lincRNA-p21 and the phosphorylation of signal transducer and activator of transcription 3 (p-STAT3) in HNSCC tissues. High lincRNA-p21 expression inhibited Janus kinase 2 (JAK2)/STAT3 signal activation and vice versa. Further, we observed direct binding to STAT3 by lincRNA-p21 in HNSCC cells, which suppressed STAT3-induced oncogenic potential. Yes Ectopic expression of lincRNA-p21 significantly inhibited cell proliferation capacity in vitro and in vivo and vice versa. Moreover, the overexpression of lincRNA-p21 induced G1 arrest and apoptosis. 30857539 TP53COR1 LncRNA Homo sapiens Atherosclerosis AS-M and peripheral blood of AS patients Interaction(miR-17-5p/SIRT7/p53) RNA Pull-Down//Western Blot//Tunel//RIP//Luciferase Report Assay//ChIP p53, lincRNA-p21, and SIRT7 were downregulated, and miR-17-5p was upregulated in AS-M and peripheral blood of AS patients. p53 positively regulated lincRNA-p21, while miR-17-5p, reversely targeted by lincRNA-p21, could target SIRT7 Yes Overexpressing p53, lincRNA-p21, or SIRT7 contributed to impaired proliferation and promoted apoptosis of VSMCs in vitro as well as reducing the vulnerable plaque and lipid accumulation in AS mice. 33169349 TP53COR1 LncRNA Homo sapiens Diabetes Mellitus, Type 2 T2DM patients, INS-1 cell Interaction(miR-766-3p/NR3C2 ) CCK8//qRT-PCR//ELISA Serum expression of LINC-P21 was elevated in T2DM patients, which was correlated with fasting blood glucose levels and disease diagnosis. miR-766-3p could be directly inhibited by LINC-P21 in INS-1 cells and reverse the effects of LINC-P21 on β-cell function. Additionally, NR3C2 was determined as a target of miR-766-3p, which could be positively regulated by LINC-P21 and had same effects with LINC-P21 on INS-1 cell proliferation and insulin secretion. Serum expression of LINC-P21 was elevated in T2DM patients, which was correlated with fasting blood glucose levels and disease diagnosis. Yes The glucose-stimulated insulin secretion and the proliferation of INS-1 cells were enhanced by LINC-P21 knockdown, but the overexpression of LINC-P21 led to opposite effects. 33007789 TP53COR1 LncRNA Homo sapiens Aortic Aneurysm, Abdominal human and mouse abdominal aortic samples Interaction(miR-204-5p/Mekk3/NF-κB pathway) RNA Pull-Down//Western Blot//ISH//qRT-PCR//Luciferase Report Assay An analysis of human and mouse abdominal aortic samples revealed that the lincRNA-p21 levels were significantly higher in AAA tissue. Collectively, the results indicated that ROS-induced lincRNA-p21 sponges miR-204-5p to accelerate synthetic and proinflammatory SMC phenotypes through the Mekk3/NF-κB pathway in AAA formation. Thus, lincRNA-p21 may have therapeutic potential for AAA formation. Yes Stimulation with hydrogen peroxide upregulated the expression of lincRNA-p21 in a dose-dependent manner and converted SMCs from a contractile phenotype to a synthetic, proteolytic, and proinflammatory phenotype in vitro. Moreover, lincRNA-p21 promoted fracture of elastic fibres, reconstruction of the vascular wall, and AAA formation in vivo by modulating SMC phenotypic switching in two mouse models of AAA induced by angiotensin II or porcine pancreatic elastase (PPE) perfusion. 36436251 TPT1-AS1 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC metastatic tissue and cell lines Regulation[PI3K/AKT signaling ] Western Blot//CCK8//FISH//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay First, TPT1-AS1 expression was significantly higher in EOC metastatic tissue and cell lines than in their respective control counterparts. Mechanistically, TPT1-AS1 was proven to be primarily distributed in EOC cell nuclei and positively modulated TPT1 promoter activity and transcription. Moreover, the oncogenic effects of TPT1-AS1 could be reversed by TPT1 depletion, and the PI3K/AKT signaling pathway downstream of TPT1 was also altered. These results suggested that TPT1-AS1 induced EOC tumor growth and metastasis through TPT1 and downstream PI3K/AKT signaling and that TPT1-AS1 may be a promising therapeutic target for EOC. Yes TPT1-AS1 overexpression remarkably induced cell proliferation, migration and invasion, and significantly attenuated cell adhesion ability in vitro and facilitated nude mouse subcutaneous xenograft growth and intraperitoneal metastasis in vivo, while the downregulation of TPT1-AS1 expression produced the opposite effect in vitro. 30941821 TPT1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[TPT1-AS1/NF90/VEGFA signaling pathway] RNA Pull-Down//Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//Transwell Assay In this study, we report that TPT1-AS1 is upregulated in CRC tissues, which is associated with poor prognosis. Therefore, we elucidate a new regulatory mechanism of TPT1-AS1 in CRC angiogenesis and targeting the TPT1-AS1/NF90/VEGFA axis may provide a useful strategy for diagnosis and treatment for colorectal cancer patients. In this study, we report that TPT1-AS1 is upregulated in CRC tissues, which is associated with poor prognosis. Yes Functional assays unravel a pro-angiogenesis and metastasis role of TPT1-AS1. 32248186 circNFXL1_009 CircRNA Homo sapiens Hypertension, Pulmonary 21 pairs of subjects Interaction(miR-29b) Transfection//Wound Healing Assay//Tunel//qRT-PCR//FISH//Luciferase Report Assay//Microarray Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) analysis further validated that hsa_circNFXL1_009 was dramatically downregulated with the highest area under a receiver operating characteristic curve (ROC) in 21 pairs of subjects. A luciferase assay showed that hsa_circNFXL1_009 directly sponged hsa-miR-29b-2-5p (miR-29b) and positively regulated the expression of voltage-gated potassium (K+) channel subfamily B member 1 (KCNB1) at the mRNA level. Yes Delivery of exogenous hsa_circNFXL1_009 attenuated hypoxia-induced proliferation, apoptotic resistance, and migration of hPASMCs, as evidenced by immunocytochemistry, 5-ethynyl-2'-deoxyuridine incorporation, wound healing, and a TUNEL (terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling) assay. 33614247 TTC39A-AS1 LncRNA Homo sapiens Cerebral Ischemia/Reperfusion Injury Neuro-2a (N-2a) cells Interaction(Htra1/HNRNPL) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//MTT//Cell Apoptosis Assay//ELISA The results showed that the overexpression of lincRNA-EPS was able to reduce the levels of interleukin-6, tumor necrosis factor-alpha and interleukin-1β stimulated in the OGD-treated Neuro-2a (N-2a) cells. Yes The depletion of Htra1 could rescue lincRNA-EPS overexpression-mediated N-2a cell injury, inflammation, and oxidative stress induced by OGD. Functionally, lincRNA-EPS alleviates CIR injury of the middle cerebral artery occlusion/reperfusion mice in vivo. I 35549989 TTN-AS1 LncRNA Homo sapiens gallbladder carcinoma GBC tissues and cells Interaction( miR-107/HMGA1 axis) Transfection//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Upregulation of lncRNA TTN-AS1 and downregulation of miR-107 were detected in GBC.Furthermore, the expressions between TTN-AS1 and miR-107 were mutually inhibited in GBC. In addition, miR-107 directly targets HMGA1. And HMGA1 can be positively regulated by lncRNA TTN-AS1 in GBC. Furthermore, HMGA1 promoted GBC progression by interacting with lncRNA TTN-AS1/miR-107 axis. Yes Functionally, lncRNA TTN-AS1 promoted cell viability and motility in GBC by sponging miR-107. 34090483 TTN-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cell lines interaction[targeting miR-211-5p] Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The results demonstrated that TTN?AS1 expression was significantly upregulated, whereas that of miR?211?5p was found to be downregulated in TNBC tissues and cell lines compared with the matched adjacent normal tissues and normal breast epithelial cell line MCF?10A, respectively. In conclusion, the findings from the present study demonstrated that TTN‑AS1 regulated the proliferation and invasive and migratory abilities of TNBC by targeting miR‑211‑5p. Yes Furthermore, TTN?AS1?knockdown inhibited the proliferation and invasive and migratory abilities of MDA?MB?453 and MDA?MB?231 cells, which was reversed following co?transfection with the miR?211?5p inhibitor. 33179096 hsa_circ_103615 CircRNA Homo sapiens lung non-small cell carcinoma NSCLC cell lines and tissues Regulation(ABCB1 ) Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay//Invasion Assay The results demonstrated that NSCLC cell lines and tissues had increased levels of circRNA_103615 compared with normal cells and normal tissues, respectively. Notably, ATP binding cassette subfamily Bmember 1 (ABCB1) expression was significantly decreased following circRNA_103615 knockdown. Yes Functionally, silencing of circRNA_103615 by small interfering RNA resulted in suppression of cell growth, migration, and invasion, but promotion of cell apoptosis. 34306203 hsa_circ_0026552 CircRNA Homo sapiens Pre-Eclampsia PE samples Interaction(miR‑331‑3p/TGF‑βR1 axis) RNA Pull-Down//Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Microarray//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay hsa_circ_0026552 differential expression in PE tissue data and clinical samples were analyzed and it was observed that hsa_circ_0026552 is highly upregulated in PE samples. It was observed that miR‑331‑3p expression was negatively correlated to hsa_circ_0026552 relative expression, while TGF‑βR1 expression was positively correlated to hsa_circ_0026552 expression evaluated by Pearson's correlation test. Mechanistically, it was concluded that hsa_circ_0026552 acts as a miR‑331‑3p sponge to upregulate TGF‑βR1 expression in trophoblasts and is involved significantly in PE development and progression in pregnant women. Yes The functional experiments, including Cell Counting Kit‑8, colony formation and Transwell assay, showed that silencing hsa_circ_0026552 could significantly strengthen the proliferation, migration and invasion of the trophoblastic HTR‑8/SVneo cells, but the subsequent overexpression of hsa_circ_0026552 reversed this. 34523694 circFryl CircRNA Homo sapiens Lung Injury adipose-derived stem cells Interaction(miR-490-3p/SIRT3 Pathway) In Vivo Experiment//Western Blot//Tunel//qRT-PCR//RNA-seq//Luciferase Report Assay//ELISA//Bioinformatics Analysis Bioinformatics and luciferase reporting experiments showed that miR-490-3p and SIRT3 are downstream targets of circ-Fryl. miR-490-3p overexpression or SIRT3 silencing reversed ADSC exosome protective effects. Taken together, our results suggest that exosomes derived from ADSCs attenuate sepsis-induced lung injury by delivery of circ-Fryl and regulation of the miR-490-3p/SIRT3 pathway. Yes Downregulation of circ-Fryl suppressed ADSC protective effects exosomes against sepsis-induced lung injury by decreasing apoptosis and inflammatory factor expression. 34478012 Ttc39aos1 LncRNA Mus musculus Myocardial Infarction MI mice and HL-1 cells Interaction(MYH6 /HNRNPL) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//MTT Significantly, lincRNA-EPS was lowly expressed in MI mice and in oxygen and glucose deprivation (OGD)-treated HL-1 cells.. Mechanically, lincRNA-EPS interacted with myosin heavy chain 6 (MYH6) and heterogeneous nuclear ribonucleoprotein L (HNRNPL), and the depletion of lincRNA-EPS and HNRNPL inhibited MYH6 mRNA stability in HL-1 cells. HNRNPL knockdown blocked lincRNA-EPS overexpression-induced MYH6 expression in the system. The depletion of MYH6 and HNRNPL could rescue lincRNA-EPS overexpression-reduced inflammation and apoptosis in HL-1 cells. Yes Echocardiography analysis revealed that lincRNA-EPS overexpression increased left ventricular ejection fraction and left ventricular fraction shortening, and decreased left ventricular internal diameter at end systole and left ventricular internal diameter at end diastole in a mouse model. In our study, the expression levels of interleukin-6, tumor necrosis factor-alpha, interleukin-1β, and interleukin-18 were upregulated in the MI mice and OGD-treated HL-1 cells, while lincRNA-EPS overexpression reversed these phenotypes. Meanwhile, lincRNA-EPS reduced MI-induced cardiomyocyte apoptosis in vivo and in vitro. 36694458 Ttc39aos1 LncRNA Mus musculus Pancreatitis, Acute Necrotizing pancreases from the saline-treated and Cer-AP mice Interaction(HMGB1) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//RNA-seq//IHC//IF Here, we have observed that the expression of pancreatic lincRNA-EPS, a long intergenic non-coding RNA, is dynamically changed during both caerulein-induced AP (Cer-AP) and sodium taurocholate-induced severe AP (NaTc-SAP). Pharmacological inhibition of NF- κB activity by BAY11-7082 significantly abolishes the suppressive effect of lincRNA-EPS on TLR4 ligand-induced inflammatory genes in macrophages. Yes Further studies indicate that knockout of lincRNA-EPS aggravates the pathological symptoms of AP including more induction of serum amylase and lipase, severe edema, inflammatory cells infiltration and acinar necrosis in both experimental AP mouse models.  33512718 TTBK2 CircRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-1283 and CHD1] qRT-PCR//Western Blot//PCR//IF circ-TTBK2 expression was increased in glioma tissues and cells.Down-regulation of circ-TTBK2 suppressed glioma development by regulating miR-1283 and CHD1, providing a new mechanism for understanding glioma pathogenesis. Yes circ-TTBK2 knockdown suppressed glioma cell proliferation, migration, invasion and glycolysis.Silence of circ-TTBK2 reduced xenograft tumor growth. 33116862 TTN-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and cell lines interaction[sponging miR-376a-3p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay The results of the present study revealed that TTN?AS1 was highly expressed in both EC tissues and cell lines, Collectively, TTN‑AS1 enhanced EC cell proliferation and metastasis by targeting the miR‑376a‑3p/PUM2 axis, which may shed light on EC diagnosis and treatment. Yes The results of the present study revealed that TTN?AS1 was highly expressed in both EC tissues and cell lines, and TTN?AS1 knockdown inhibited EC cell proliferation, migration and invasion. 32945477 TTBK2 CircRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-761/ITGB8 axis] qPCR//MTT//PCR//IF Levels of circ-TTBK2 and ITGB8 were upregulated, whereas miR-761 level was low-expressed in glioma tissues and cells.Circ-TTBK2 regulated cell proliferation, invasion and ferroptosis via targeting ITGB8 by sponging miR-761 in glioma, providing a promising biomarker for the clinical therapy of human glioma. Yes Additionally, circ-TTBK2 knockdown or miR-761 increase could retard cell proliferation, invasion, and promote ferroptosis in glioma cells. 32196629 TSPOAP1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[THBS1 ] RNA Pull-Down//qRT-PCR//RIP//Microarray//ChIP BZRAP1-AS1 was identified as a highly expressed lncRNA in HCC tissues and cells. By interacting with DNMT3b, BZRAP1-AS1 induced methylation of the THBS1 promoter and inhibited the transcription of THBS1, resulting in promoted angiogenesis of HUVECs. Down-regulation of BZRAP1-AS1 in HCC cells inhibited HUVEC proliferation, migration and angiogenesis. Yes Moreover, silencing of BZRAP1-AS1 repressed the angiogenesis as well as the tumor growth of HCC in vivo via up-regulating THBS1. 31847842 TSPOAP1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues Expression(lower expressed) In Vivo Experiment//Migration Assay//qRT-PCR//RNA-seq//Colony Formation Assay//Invasion Assay Compared with adjacent normal tissues, BZRAP1-AS1 showed lower expression in NSCLC tumor tissues. BZRAP1-AS1 was lower in T1 than T2-T4 patients, N1-N3 than N0 patients. Low level BZRAP1-AS1 was related to shorter overall survival time (OS) in lung adenocarcinoma (LUAD), and poor first progression time (FP) in LUAD and lung squamous cell carcinoma (LUSC) patients. Yes Overexpression of BZRAP1-AS1 inhibited proliferation and migration of H1299 and HCC827 cells. 36032951 TSPOAP1-AS1 LncRNA Homo sapiens Arthritis, Rheumatoid RA tissues Interaction(miR-1286/COL5A2 axis) RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//ELISA BZRAP1-AS1 and COL5A2 were downregulated in RA tissues and RA-HFLS while miR-1286 was amplified. Our findings suggested that BZRAP1-AS1 sequestered miR-1286 and reshaped the COL5A2 expression, thereby suppressed RA-HFLS proliferation and inflammation, and triggered cell apoptosis, resulting in the attenuation of RA progression. Yes Overexpression of BZRAP1-AS1 reduced the RA-HFLS proliferation, IL-6, IL-1β, and TNF-α level and induced cell apoptosis while BZRAP1-AS1 silence produced an opposite effect.Overexpression of BZRAP1-AS1 reduced the miR-1286 expression which in turn increased the COL5A2 expression, thereby relieving the excessive proliferation and limited apoptosis in RA-HFLS. 34766472 TSPEAR-AS2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tumors and cells Interaction(miR-487a-3p/PPM1A axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay TSPEAR-AS2 was overexpressed in OSCC tumors and cells. Luciferase reporter tests and RNA pull-down results revealed that TSPEAR-AS2 enhanced the expressions of PPM1A by regulating miR-487a-3p, and TSPEAR-AS2 could be adopted as a miR-487a-3p sponge to inhibit PPM1A expression. High TSPEAR-AS2 was associated with advanced TNM stage. Patients with high TSPEAR-AS2 expression displayed a shorter disease-free survival and total survival of OSCC patients than those with low TSPEAR-AS2 expressing level. Yes It was found that knockdown of TSPEAR-AS2 could inhibit the proliferating, invading, and migrating processes pertaining to OSCC cells. 34336002 TSPEAR-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HBV-HCC tissues, HBV-HCC cell lines Interaction(miR-1915-5p) Transfection//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay The TSPEAR-AS1 expression was downregulated in HBV-HCC tissues, as well as in HBV-HCC cell lines. Overexpression of TSPEAR-AS1 inhibited HBV-HCC cell ability of proliferation, migration, and invasiveness. TSPEAR-AS1 may bind to miR-1915-5p in HCC. The downregulation of TSPEAR-AS1 showed a significant association with TNM stage, clinical stage, and vascular invasion and predicted poor prognosis of HBV-HCC patients. Yes Overexpression of TSPEAR-AS1 inhibited HBV-HCC cell ability of proliferation, migration, and invasiveness. TSPEAR-AS1 may bind to miR-1915-5p in HCC. 35477008 TSLC8 LncRNA Homo sapiens Colorectal Neoplasms CRC samples and cell lines regulation[stabilizing puma] CCK8//qRT-PCR TSLC8 was dramatically downregulated in CRC samples and cell lines.Ectopic TSLC8 expression elevates puma abundance whereas this effect is mediated by TSLC8-puma binding and stabilization. Yes In vivo experiments further confirmed the tumor suppressive function of TSLC8. 33218295 hsa_circ_0020339 CircRNA Homo sapiens Acute Kidney Injury plasma of patients, cell lines and mouse model Interaction(miR-17-5p/IPMK axis) RNA Pull-Down//Western Blot//H&E Staining//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Microarray//ELISA Circ_0020339 was upregulated in the plasma of patients with septic AKI as well as LPS-treated HK2 cells and C57BL/6 mice relative to the corresponding counterparts.Furthermore, circ_0020339 and IPMK 3'UTR shared the same complementary sites with miR-17-5p. Yes Functionally, circ_0020339 was positively correlated with markers of renal functional injury and inflammation in patients with septic AKI; si-circ_0020339 facilitated cell proliferation, while restrained cell apoptosis and inflammation in LPS-triggered HK2 cells; meanwhile, si-circ_0020339 restrained survival rate, renal functional injury and inflammation in LPS-triggered C57BL/6 mice. 35986866 TTN-AS1 LncRNA Homo sapiens Prostatic Neoplasms "cell lines( DU145, PC3, 22RV1, C4-2B, LNCaP)" Interaction[sponging miR-193a-5p] qRT-PCR//MTT//Luciferase Report Assay//Western Blot The relative expression of TTN-AS1 was apparently Expression[up-expression]-regulated, and the level of miR-193a-5p was strikingly down-regulated in PCa cells. Furthermore, the recExpression[up-expression]erated experiments exhibited that miR-193a-5p inhibitor counteracted the inhibitory effect on cell viability and the promotion effect on cell apoptosis rate in DU145 and PC3 cells induced by TTN-AS1 silencing. Yes The functional experiments indicated that TTN-ASI knockdown or miR-193a-5p inhibited cell viability and induced cell apoptosis rate in DU145 and PC3 cells. 31599406 TTN-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cell lines regulation[TTN-AS1/miR-195/cyclin D1 regulatory axis ] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay Our results revealed that TTN-AS1 expression levels in human ccRCC tissues and cell lines were markedly increased.Our study provides a novel mechanism of TTN-AS1/miR-195/cyclin D1 regulatory axis in ccRCC, which may become a breakthrough for ccRCC therapy in the future. Yes Gain- and loss-of-function experiments showed that TTN-AS1 overexpression promoted the proliferation and cell cycle transition of ccRCC cells, while the malignant traits were obviously suppressed after TTN-AS1 knockdown. 32440207 TRPM2-AS LncRNA Homo sapiens Stomach Neoplasms 26 GC tissues Expression(highly expressed) Western Blot//Migration Assay//qRT-PCR//FISH//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Invasion Assay//ChIP By using bioinformatics and quantitative polymerase chain reaction methods, TRPM2-AS expression levels were proved to be upregulated in GSE70880 dataset, TCGA database, and 26 GC tissues, which was partly induced by SP1. The results of clinical assays showed that TRPM2-AS could be an indicator for early-stage GC diagnosis. Yes Functional experiments displayed that knockdown of TRPM2-AS inhibited proliferation, migration, and invasion in GC cells. Furthermore, depression of TRPM2-AS suppressed cell growth though promotion of cell apoptosis. The expression levels of cleaved PARP, caspase 9, caspase 3, and Bax were significantly increased in BGC823 with TRPM2-AS knockdown. 32424838 circSWT1 CircRNA Homo sapiens lung non-small cell carcinoma NSCLC tissues and cells Interaction(miR-370-3p/SNAIL ) In Vivo Experiment//RNA Pull-Down//Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RIP//IF//IHC//Transwell Assay CircSWT1 expression was significantly upregulated in NSCLC tissues, and high expression of circSWT1 predicted poor prognosis in NSCLC via survival analysis. Mechanistically, circSWT1 relieved the inhibition of downstream SNAIL by sponging miR-370-3p. Moreover, we found that these effects could be reversed by knocking out SNAIL. Finally, we verified that circSWT1 promoted NSCLC progression and EMT in xenograft tumor models. CircSWT1 expression was significantly upregulated in NSCLC tissues, and high expression of circSWT1 predicted poor prognosis in NSCLC via survival analysis. Yes In addition, overexpression of circSWT1 promoted the invasion and migration of NSCLC cells. Subsequently, we found that overexpression of circSWT1 induced EMT and that knockdown of circSWT1 inhibited EMT in NSCLC cells. 36530171 TTN-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation[miR-376a-3p/KLF15 axis] CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay TTN-AS1 upregulation was observed both in CRC tissues and cell lines. Bioinformatics analysis identified miR-376a-3p as a target of TTN-AS1. Transfection of miR-376a-3p inhibitor mitigated the alterations induced by TTN-AS1 knockdown. Moreover, TTN-AS1 positively regulated KLF15 via sponging miR-376a-3p. Additionally, these findings were supported by in vivo experiments. Yes Functional investigation showed that knockdown of TTN-AS1 inhibited CRC cell proliferation and invasion, while enhanced cell apoptosis. 31610194 TTN-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(MicroRNA-134/ITGB1 Axis) qRT-PCR//RNA Pull-Down//Western Blot TTN-AS1 and ITGB1 were highly expressed, while miR-134 was poorly expressed in HCC tissues. TTN-AS1 enforced ITGB1 expression through sequestering miR-134. Yes Silencing of TTN-AS1 or over-expression of miR-134 inhibited proliferation, invasion, migration, and resistance to death of Huh7 cells. Following miR-134 silencing, further down-regulation of ITGB1 suppressed the malignant behaviors of HUH7 cells. The similar results were reproduced in vivo. 33387127 TTN-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Interaction(miR-139-5p/SPOCK1 axis) qRT-PCR We demonstrated that, TTN-AS1 and SPOCK1 expression levels were remarkably enhanced in HCC cells and tissues, whereas miR-139-5p expression was observably reduced. In addition, TTN-AS1 interacted with miR-139-5p and decreased its expression. Moreover, SPOCK1 was a miR-139-5p target, and miR-139-5p inhibitors were able to reverse TTN-AS1 knockdown-induced inhibitory effect on SPOCK1 expression. SPOCK1 overexpression plasmid could counteract TTN-AS1 knockdown-induced inhibiting impact on HCC cell multiplication, migration, invasion, and EMT. Yes Functional experiments suggested that TTN-AS1 knockdown markedly repressed HCC cell multiplication, migration, epithelial-mesenchymal transition (EMT), and invasion. 33517826 TTN-AS1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cells regulation[TTN-AS1/miR-15b-5p/FBXW7 axis] CCK8//qRT-PCR//Flow Cytometry TTN-AS1 was found decreased expression in ovarian cancer tissues and cells.Our results indicated that the TTN-AS1/miR-15b-5p/FBXW7 axis identified in this work could help to identify treatment biomarkers for ovarian cancer. Yes Functional assays showed TTN-AS1 overexpression inhibits ovarian cancer cell proliferation, colony formation but promotes apoptosis. 32049388 TTN-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Regulation(ATF2) qRT-PCR//MTT The higher expression of TTN-AS1 was related to poorer disease-free survival (DFS) in patients with BC. ATF2 may serve as a downstream target of TTN-AS1 in BC, and the high expression of ATF2 is also related to adverse DFS. The higher expression of TTN-AS1 was related to poorer disease-free survival (DFS) in patients with BC. The expression of TTN-AS1 was higher in BC patients who underwent Re-TURBT compared with BC patients who underwent TURBT. Yes Knocking down TTN-AS1 resulted in inhibiting the ability of proliferation and invasion of BC cells. 34671381 TTN-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cells regulation[miR-411-3p/NFAT5 axis] Wound Healing Assay//Tunel//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining TTN-AS1 expression was stronger in OSCC cells. lncRNA TTN-AS1 contributed to the progression of OSCC via miR-411-3p/NFAT5 axis. Yes Knockdown of TTN-AS1 effectively restrained cell proliferation and migration but had inductive role in apoptosis. 32863773 TTN-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(miR-199a-3p/RUNX1 ) qRT-PCR//Wound Healing Assay//Bioinformatics Analysis Our results revealed that TTN-AS1 and RUNX1 were upregulated in OSCC tissues and cells, whereas miR-199a-3p expression was downregulated. Additionally, miR-199a-3p inhibitor partly relieved the effects of silencing TTN-AS1 and RUNX1 in OSCC cells due to their targeting relationship. Yes Knockdown of TTN-AS1 or RUNX1 suppressed cell proliferation, adhesion, and migration but induced apoptosis. 34606420 hsa_circ_0020123 CircRNA Homo sapiens lung non-small cell carcinoma NSCLC tissues and cell lines Interaction( miR-940/KIAA1522 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Invasion Assay Circ_0020123 was highly expressed in NSCLC tissues and cell lines, and knockdown of circ_0020123 abolished cell growth, migration and invasion in vitro and hindered tumor growth in nude mice.Mechanically, circ_0020123 directly targeted miR-940, and KIAA1522 was a target of miR-940. Thereafter, a series of rescue experiments showed that circ_0020123 served its biological functions by miR-940/KIAA1522 axis. Yes Circ_0020123 was highly expressed in NSCLC tissues and cell lines, and knockdown of circ_0020123 abolished cell growth, migration and invasion in vitro and hindered tumor growth in nude mice. 35196193 TTN-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues Interaction(miR-16-1-3p/TFAP4 Axis) qRT-PCR//Wound Healing Assay//MTT//Transwell Assay TTN-AS1 and TFAP4 expression was increased in OS, while miR-16-1-3p expression was decreased. TTN-AS1 played a carcinostatic role by down-regulating miR-16-1-3p in the OS cells. Moreover, miR-16-1-3p inhibition or TFAP4 elevation weakened the suppressive effect of TTN-AS1 silencing on OS cell tumor progression. Yes TTN-AS1 silencing restrained OS cell proliferation, migration, invasion, N-cadherin and MMP-2 protein expression, and hindered tumor growth. MiR-16-1-3p overexpression retarded the malignant behavior of OS cells. 34141611 TTN-AS1 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues Interaction( miR-513a-5p/SFN pathway) In Vivo Experiment//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//EdU Staining The result showed that TTN-AS1 and SFN are highly expressed in CCA tissues. Bioinformatics analysis, luciferase reporter and RIP experiments revealed the correlation between TTN-AS1, miR-513a-5p, and SFN. Furthermore, we showed that miR-513a-5p is a regulator of CCA by targeting SFN. TTN-AS1 induced CCA cell growth and metastasis via the miR-513a-5p/SFN pathway, which offers a new strategy for therapeutic interventions for CCA. Yes In addition, silencing TTN-AS1 mitigated CCA cell proliferation and migration. Mechanistically, miR-513a-5p is sponged by TTN-AS1. The miR-513a-5p inhibitor abolished the effect of TTN-AS1 silencing on the aggressive behaviors of CCA cells. 34903127 TTN-AS1 LncRNA Homo sapiens Glioma glioma tissues and cell lines interaction[ sponging miR-27b-3p] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The results revealed that TTN?AS1 was highly expressed in glioma specimens and cell lines. In conclusion, the present study supported that TTN‑AS1 acts as an oncogene in glioma by targeting miR‑27b‑3p to release RUNX1. This finding may contribute to gene therapy of glioma. Yes Downregulation of TTN?AS1 inhibited the proliferation, migration and invasion of the glioma cells, as well as increased the rate of apoptosis. In vivo, the tumor growth was also inhibited by TTN?AS1 depletion in nude mice. 32705233 TTN-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and four PTC cells Regulation[miR-153-3p/ZNRF2 axis] qRT-PCR A high level of TTN-AS1 was observed in PTC tissues and cells.Mechanistically, TTN-AS1 acted as a competing endogenous RNA by sponging microRNA-153-3p (miR-153-3p) to elevate zinc and ring finger 2 (ZNRF2) expression. Additionally, a high level of TTN-AS1 in PTC was closely correlated with the activity of the phosphoinositide 3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) pathway. The expression level of TTN-AS1 is possibly associated with lymphatic metastasis, TNM stage and the overall survival of PTC patients. Yes Functionally, TTN-AS1 knockdown inhibited cell proliferation, migration, invasion and epithelial-mesenchymal transition in PTC, whereas overexpression of TTN-AS1 led to the opposite results. 30811764 TTN-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC cell lines and tissues Interaction(microRNA-589-5p/FOXP1 positive feedback loop) ChIP//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay As a result, TTN-AS1 and FOXP1 were found to be upregulated in PC cell lines and tissues, while miR-589-5p was expressed at low levels. Further mechanistic research uncovered that TTN-AS1 functioned as a molecular sponge for miR-589-5p and its mRNA expression level in PC tissues was inversely associated with that of miR-589-5p. Furthermore, miR-589-5p was confirmed to target FOXP1. Yes Knockdown experiments indicated the suppressive effect of TTN-AS1 knockdown on cell proliferation, migration and invasion in PC cell lines. 34584569 hsa_circ_0041268 CircRNA Homo sapiens lung non-small cell carcinoma NSCLC cell lines Interaction(miR-214-5p/ROCK1) In Vivo Experiment//qRT-PCR//migration assay//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay The result shows that the expressions of hsa_circ_0041268 incremented in NSCLC cell lines and hsa_circ_0041268 downregulation decreased cell proliferation and migration. ROCK1 and miR-214-5p were hsa_circ_0041268 downstream targets. miR-214-5p downregulation or ROCK1 overexpression restored migration and proliferation abilities after hsa_circ_0041268 silencing. ROCK1 overexpression renovated migration and proliferation abilities after miR-214-5p overexpression. Yes The result shows that the expressions of hsa_circ_0041268 incremented in NSCLC cell lines and hsa_circ_0041268 downregulation decreased cell proliferation and migration. In vivo investigations confirmed that hsa_circ_0041268 downregulation inhibited tumor formation and metastasis in nude mice xenografts. 35212425 TTN-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung lung tissue Regulation[PTEN/PI3K/AKT signaling pathway] Western Blot//Co-IP//CCK8//qRT-PCR//Transwell Assay Mechanically, TTN-AS1 knockdown enhanced the level of PTEN protein while reduced p-AKT level. Meanwhile, PTEN inhibition observably recovered the repressive effect of TTN-AS1 silence on the biological behaviors of A549 cells. What's more, we demonstrated that TTN-AS1 modulated PTEN expression not at mRNA level but protein level. Intriguingly, TTN-AS1 was uncovered to reduce PTEN stability via inhibiting the interactivity of PTEN with MAGI2. Jointly, our findings unveiled that TTN-AS1 plays a carcinogenic part in LAD progression through destabilizing PTEN protein so as to activate PI3K/AKT pathway, therefore indicating TTN-AS1 as a promising target for LAD treatment. Yes Functionally, silencing TTN-AS1 resulted in inhibited cell proliferation and migration in LAD cells. 31027732 TTN-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines Regulation[TTN-AS1/miR-142-5p/CDK5 regulatory axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay In the present study, we revealed that the expression of TTN-AS1 was upregulated in LUAD tissues and cell lines. Then, by using bioinformation analysis and luciferase reporter experiment, we identified that TTN-AS1 could function as a competing endogenous RNA (ceRNA) by sponging miR-142-5p to regulate the expression of cyclin-dependent kinase 5 (CDK5) in LUAD. Since CDK5 is a key regulator in the process of epithelial mesenchymal transition (EMT), we detected the expression of EMT-related proteins, consequently, EMT was suppressed by knockdown of TTN-AS1 while this phenomenon was rescued by miR-142-5p inhibitor. Taken above, our study revealed that TTN-AS1 played an important role in LUAD progression. TTN-AS1/miR-142-5p/CDK5 regulatory axis may serve as a novel therapeutic target in the treatment of LUAD. High TTN-AS1 expression was associated with TNM stage and lymph node metastasis of LUAD patients. In addition, high expression of TTN-AS1 was correlated with poor postoperative prognosis of LUAD patients. Yes Knockdown of TTN-AS1 significantly inhibited the growth, proliferation, migration, and invasion ability of LUAD cells in vitro. 31363080 TTN-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues,cell lines Regulation[miR-4677-3p/ZEB1 axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this study, we observed that TTN-AS1 was upregulated in tissues and cells of lung adenocarcinoma and associated with poor overall survival.To sum up, our study offers insights into the mechanism of TTN-AS1 in lung adenocarcinoma metastasis and targeting the TTN-AS1/miR-4677-3p/ZEB1 axis may be the potential innovate therapeutic strategy for the patients with lung adenocarcinoma. In this study, we observed that TTN-AS1 was upregulated in tissues and cells of lung adenocarcinoma and associated with poor overall survival. Yes TTN-AS1 promoted cell proliferation, migration, invasion, and epithelial-mesenchymal transition in lung cancer. 31173403 TTN-AS1 LncRNA Homo sapiens Cholangiocarcinoma cholangiocarcinoma tissues and cells regulation[miR-320a/neuropilin-1 axis] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP Here we report lncRNA TTN-AS1 (titin-antisense RNA1) acts as a sponging ceRNA to downregulate miR-320a and is highly expressed in human cholangiocarcinoma tissues and cells. In conclusion, the present results demonstrate that lncRNA TTA-AS1 is a sponging ceRNA for miR-320a, which in turn downregulates neuropilin-1 in cholangiocarcinoma cells, indicating these three molecules represent potential biomarkers and therapeutic targets in the management of cholangiocarcinoma. Yes TTN-AS1 promoted the proliferation and migration of cholangiocarcinoma cells via the miR-320a/ neuropilin-1 axis. The function of TTN-AS1 on tumor growth and its interaction with miR-320a were confirmed in animal models. 32801339 TRPM2-AS LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Regulation[miR-195/HMGA1 signaling axis] qRT-PCR In the current study, we provided evidence that the expression levels of TRPM2-AS were increased in both GC tissues and cell lines. In terms of mechanism, we found that TRPM2-AS directly inhibited miR-195, which targeted the 3'-untranslated region of high-mobility group AT-hook 1 (HMGA1) messenger RNA. Overall, these findings revealed that ELK1-induced overexpression of TRPM2-AS promoted the development and progression of GC in part through miR-195/HMGA1 signaling axis, and established its candidacy as a new cancer biomarker for GC patients. The results of clinical assays showed that higher expressions of TRPM2-AS were significantly related with invasion depth, TNM stage, lymphatic metastasis, and shorter overall survival. Further clinical assays using multivariate analysis suggested that TRPM2-AS expression was an independent prognostic factor in patients with GC. Yes Functional experiments illustrated that depression of TRPM2-AS suppressed proliferation, migration, and invasion in GC cells. 31104318 TRPM2-AS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumors and cell lines regulation[TRPM2-AS/miR-138-5p] qRT-PCR//Luciferase Report Assay TRPM2-AS was up-regulated in NSCLC tumors and cell lines. These findings highlight TRPM2-AS/miR-138-5p as a potential target for reducing drug resistance in patients with NSCLC. Yes Cell proliferation, migration, and invasion were inhibited in NSCLC cells treated with sh-TRPM2-AS, while apoptosis was induced. 33209893 TPT1-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues regulation[TPT1-AS1/miR-330-3p/QKI axis] CCK8//qRT-PCR//Transwell Assay In the present study, TPT1-AS1 expression was decreased in BC tissues, based on RNA-seq data download from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases and the qRT-PCR results confirmed the above findings.Based on these findings, TPT1-AS1 potentially represents a prognostic biomarker for patients with BC and participates in the development of BC through the TPT1-AS1/miR-330-3p/QKI axis. Otherwise, low TPT1-AS1 expression was significantly associated with some clinical features of malignancy, such as high TNM stage, lymph node metastasis, a Her-2-negative status, and shorter overall survival. Yes Overexpression and knockdown of TPT1-AS1 in BC cell lines altered their proliferation, metastasis and invasion, as measured using the cell counting kit-8 (CCK-8) assay, wound-healing assay and transwell assay, respectively. 32961484 TPTEP1 LncRNA Homo sapiens Stomach Neoplasms gastric cells Interaction(miR-548d-3p/KLF9/PER1 axis) Western Blot//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//IHC TPTEP1 inhibited its expression by sponge adsorption of miR-548d-3p. miR-548d-3p targets KLF9 3'UTR to inhibit its expression, and KLF9 binds to the PER1 promoter to promote its expression.TPTEP1/KLF9/PER1 inhibits gastric cancer cell migration and invasion, and miR-548d-3p does the opposite. Yes TPTEP1/KLF9/PER1 inhibits gastric cancer cell migration and invasion, and miR-548d-3p does the opposite. 35985238 circTP63 CircRNA Homo sapiens estrogen-receptor positive breast cancer cell lines Interaction(miR-873-3p/FOXM1 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//Transwell Assay First, we observed increased expression of circTP63 in MCF7 cells relative to normal human mammary epithelial cell lines, such as DU4475 and MCF-10A, and the changed oncogenicity of MCF7 cells correlated with circTP63 overexpression and downregulation. Further investigations showed that circTP63 sponged to miR-873-3p, which targeted FOXM1 mRNA and inhibited its expression. Yes Interestingly, a series of gain- and loss-of-function assays revealed that a higher level of FOXM1 was closely associated with MCF7 malignant behaviors induced by circTP63 overexpression. 33136699 TRERNA1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[ recruitment of the EHMT2/SNAI1 complex ] Western Blot//Wound Healing Assay//qRT-PCR//RIP//IP//ChIP The data showed that TRERNA1 demonstrated higher expression levels in the tumour tissues compared with that in the pair‐matched adjacent non‐tumour tissues (Figure ​(Figure6A).6A). For the first time, the current study reveals that TRERNA1 promotes cell metastasis and the invasion of HCC via the recruitment of EHMT2 and/or the EHMT2/SNAI1 complex to suppress CDH1. Yes Elevated TRERNA1 levels promoted HCC cell migration and invasion in vitro and in vivo. 31012192 circRPPH1 CircRNA Homo sapiens Glioblastoma GSCs Interaction(UPF1/circRPPH1/ATF3) In Vivo Experiment//RNA Pull-Down//Northern Blot//Western Blot//Bioinformatics Analysis//Transfection//EdU Staining//qRT-PCR//FISH//RIP//IF//Luciferase Report Assay//ELISA//IHC//Invasion Assay//ChIP Our study found a novel circular RNA (circRPPH1) that was up-regulated in GSCs and correlated with poor survival. Mechanistically, UPF1 can bind to circRPPH1 and maintain its stability. Therefore, more existing circRPPH1 can interact with transcription factor ATF3 to further transcribe UPF1 and Nestin expression. It formed a feedback loop to keep a stable stream for stemness biomarker Nestin to strengthen tumorigenesis of GSCs continually. Besides, ATF3 can activate the TGF-β signaling to drive GSCs for tumorigenesis. Our study found a novel circular RNA (circRPPH1) that was up-regulated in GSCs and correlated with poor survival. Yes Knocking down the expression of circRPPH1 significantly inhibited the proliferation and clonogenicity of GSCs both in vitro and in vivo. The overexpression of circRPPH1 enhanced the self-renewal of GSCs. Our findings suggest that UPF1/circRPPH1/ATF3 maintains the potential self-renewal of GSCs through interacting with RNA-binding protein and activating the TGF-β signal pathway. 35871061 circHEATR5B CircRNA Homo sapiens Glioblastoma GBM tissues and cells Interaction( HEATR5B-881aa/JMJD5) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//FISH//RNA-seq//Luciferase Report Assay//Microarray//Cell Proliferation Assay//IF These genes were expressed at low levels in GBM tissues and cells. Both ZCRB1 and circHEATR5B overexpression suppressed aerobic glycolysis and proliferation in GBM cells. ZCRB1 overexpression promoted the Alu element-mediated formation of circHEATR5B. In addition, circHEATR5B encoded a novel protein HEATR5B-881aa which interacted directly with Jumonji C-domain-containing 5 (JMJD5) and reduced its stability by phosphorylating S361. Yes Finally, ZCRB1, circHEATR5B and HEATR5B-881aa overexpression inhibited GBM xenograft growth and prolonged the survival time of nude mice. 35538499 hsa_circ_0003420 CircRNA Homo sapiens Inflammation In Sepsis-Induced Liver Damage Human hepatic tissue samples Expression [highly expressed] Western Blot//Bioinformatics Analysis//qPCR//CCK8//Flow Cytometry//Luciferase Report Assay//EdU Staining We observed circ_0003420 upregulation accompanied by NPAS4 downregulation in liver samples from patients with sepsis-associated damage and in Kupffer cells treated with LPS. Yes Circ_0003420 silencing counteracted LPS’s influence on cell proliferation, apoptosis, and inflammation signs. Bioinformatics and a dual-luciferase reporter assay revealed that circ_0003420 targets NPAS4 mRNA and negatively correlates with NPAS4 expression. 33719821 circERBB2 CircRNA Homo sapiens Her2-receptor positive breast cancer tumor tissues Interaction(miR-136-5p and miR-198) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//H&E Staining//Transwell Assay Circ-ERBB2 was elevated in the tumor tissues of HER2-positive breast cancer patients. Furthermore, the mechanistic analysis corroborated that circ-ERBB2 acted as a competing endogenous RNA for miR-136-5p or miR-198 to relieve the repressive influence of miR-136-5p or miR-198 on its target transcription factor activator protein 2C (TFAP2C). Yes Functionally, the interference with circ-ERBB2 repressed HER2-positive breast cancer cell proliferation, migration, invasion and accelerated cell apoptosis. 34732216 circNDUFB2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(TRIM25/circNDUFB2/IGF2BPs axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//Microarray Here we identify circNDUFB2 to be downregulated in non-small cell lung cancer (NSCLC) tissues, and to negatively correlate with NSCLC malignant features. Mechanistically, circNDUFB2 functions as a scaffold to enhance the interaction between TRIM25 and IGF2BPs, a positive regulator of tumor progression and metastasis. Here we identify circNDUFB2 to be downregulated in non-small cell lung cancer (NSCLC) tissues, and to negatively correlate with NSCLC malignant features. Yes Elevated circNDUFB2 inhibits growth and metastasis of NSCLC cells. 33436560 TRAF3IP2 LncRNA Homo sapiens Carcinoma, Renal Cell NONO-TFE3 tRCC tissues and cells Interaction(NOTCH1 pathway) RNA Pull-Down//Northern Blot//Western Blot//Flow Cytometry//qRT-PCR//IHC The results showed that TRAF3IP2 was highly expressed in NONO-TFE3 tRCC tissues and cells, and the silence of TRAF3IP2 inhibited the proliferation, migration, and invasion of UOK109 cells which were derived from cancer tissue of patient with NONO-TFE3 tRCC.Mechanistic studies revealed that TRAF3IP2 functioned as a co-activator of NOTCH1 to activate the NOTCH1 pathway. Meanwhile, HNRNPK, DNMT1 and SETDB1 could be recruited by TRAF3IP2-AS1 to the promoter region of TRAF3IP2, which mediated 5-hydroxymethylcytosine (5mC) on DNA and trimethylated lysine 9 of histone H3 (H3K9me3) at transcriptional level to repress the expression of TRAF3IP2. Yes The results showed that TRAF3IP2 was highly expressed in NONO-TFE3 tRCC tissues and cells, and the silence of TRAF3IP2 inhibited the proliferation, migration, and invasion of UOK109 cells which were derived from cancer tissue of patient with NONO-TFE3 tRCC. 35897085 TPTEP1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues interaction[sponges miR-328-5p] qRT-PCR//Luciferase Report Assay//Western Blot In the present study, significant downregulation of TPTEP1 in tumors compared with normal tissues from patients with NSCLC was observed. Using a dual‑luciferase reporter assay and western blot analysis, it was further validated that TPTEP1 sponged miR‑328‑5p to upregulate Src kinase signaling inhibitor 1 (SRCIN1) in NSCLC cells. Yes Overexpression of TPTEP1 inhibited cell proliferation and induced apoptosis in NSCLC cells. 32323798 TRERNA1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissue interaction[targeting FOXL1] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay QRT-PCR results indicated that the expression level of lncRNA TRERNA1 in tumor tissue samples of NSCLC patients was remarkably higher than that in adjacent tissues. Compared with NSCLC patients with low expression of TRERNA1, patients with high TRERNA1 expression had a worse pathological stage and overall survival. Yes Similarly, compared with cells in sh-NC group, the proliferation ability of cells in sh-TRERNA1 group was remarkably attenuated. In addition, cell ratio in the G1 phase increased after knockdown of TRERNA1, suggesting the arrested G1/S cell cycle. 32096153 TPTEP1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-761/LATS2 axis) Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Compared with the normal adjacent tissues, the expressions of TPTEP1 and LATS2 were significantly down-regulated in the NSCLC tissues, while the expression of miR-761 was significantly increased. LATS2 was identified as a direct target of miR-761. Overexpression of miR-761 could significantly block the inhibitory effects of TPTEP1 on NSCLC, which clearly indicated that miR-761 played an oncogenic role in promoting proliferation and metastasis, while its downstream factor, LATS2, exerted opposite effects. Yes Overexpression of TPTEP1 exhibited substantial antitumor effects on NSCLC, including inhibition of cell proliferation and metastasis, which was achieved by targeting miR-761 and subsequently attenuated the expression of LATS2. 34539985 hsa_circ_0001360 CircRNA Homo sapiens Skin Neoplasms Cscc Tissue samples Expression [lower expressed] Migration Assay//RNA-seq//Cell Apoptosis Assay//Colony Formation Assay//Invasion Assay Of four selected circRNAs, two circRNAs (hsa_circ_0000932 and hsa_circ_0001360) were confirmed to be significantly decreased in cSCC using PCR, Sanger sequencing and quantitative RT-PCR. Yes Furthermore, hsa_circ_0001360 silencing was found to result in a significant increase of the proliferation, migration and invasion but a significant decrease of apoptosis in SCL-1 cells in vitro, whereas hsa_circ_0001360 overexpression showed the opposite regulatory effects. 33569895 TPTEP1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Interaction(microRNA-454-3p) RNA Pull-Down//IHC//Western Blot//CCK8//RIP//FISH//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay LncRNA TPTEP1 was downregulated both in HCC cells and tissues, and played a negative regulatory role in HCC cell proliferation, migration and invasion. Yes Overexpression of lncRNA TPTEP1 inhibits proliferation, invasion and migration of HCC cells in vitro 34238665 hsa_circ_0124554 CircRNA Homo sapiens Colorectal Cancer Liver Metastasis tumor tissues Interaction(AKT) In Vivo Experiment//RNA Pull-Down//Northern Blot//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//FISH//RIP//RNA-seq//Cell Proliferation Assay//Transwell Assay We identified the aberrant increased circRNA circ_0124554 (also entitled as circ-LNLM) in tumor tissues of LNLM1 patients comparing with either the tumor tissues of LNLM0 or adjacent tissues of LNLM1. Ectopic expression of cytoplasmic located circ-LNLM could promote invasion of CRC cells and induced the liver metastasis in animal models through the direct binding with AKT. Circ-LNLM1 expression was highly correlated with liver metastasis and vascular invasion.  Yes Ectopic expression of cytoplasmic located circ-LNLM could promote invasion of CRC cells and induced the liver metastasis in animal models through the direct binding with AKT. 33723214 TPTE2P1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] Flow Cytometry//qRT-PCR//Colony Formation Assay//Western Blot TPTE2P1 levels were significantly higher in CRC tissues than in adjacent normal tissues. Higher expression was associated with a poor survival rate. Yes The silencing of TPTE2P1 led to cell cycle arrest at the S phase and thereby inhibited cell viability. TPTE2P1 knockdown also caused cancer cell apoptosis via the activation of the apoptosis regulator (BCL2)/caspase 3 signaling cascade. 30382596 TPTE2P1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Expression[highly expressed] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay Results found that lncRNA-TPTE2P1 was overexpressed in both HCC tissues and cell lines.Moreover, lowly expressed lncRNA-TPTE2P1 significantly decreased the protein levels of E-cadherin, Vimentin and N-cadherin. These results indicated that lncRNA-TPTE2P1 might stimulate the migration and invasion of HCC cells by promoting epithelial-mesenchymal transition (EMT). Further analysis revealed that overexpression of lncRNA-TPTE2P1 was correlated with tumor size, distant metastasis, differentiation degree, as well as tumor node metastasis (TNM) stage of HCC patients. Yes Subsequent wound-healing assay, transwell assay and Matrigel assay confirmed that down-regulated lncRNA-TPTE2P1 could significantly suppress the invasion and migration of cells. However, up-regulation of lncRNA-TPTE2P1 showed the opposite results. 31114999 hsa_circ_0003998 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung primary NSCLC and 25 recurrent NSCLC patients after cure with DTX-based chemotherapy Interaction(miR-136-5p/CORO1C Axis) In Vivo Experiment//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay Our data indicated that circ_0003998 expression was associated with NSCLC resistance to docetaxel (DTX). Mechanistically, circ_0003998 directly targeted miR-136-5p, and miR-136-5p was a molecular mediator of circ_0003998 function in vitro. Yes The knockdown of circ_0003998 promoted DTX sensitivity, suppressed cell colony formation, and enhanced cell apoptosis of A549/DTX and H1299/DTX cells in vitro. Moreover, circ_0003998 knockdown hampered tumor growth and enhanced DTX sensitivity in vivo. 33511909 TPT1‑AS1 LncRNA Homo sapiens Liver Neoplasms LC cell Regulation Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//cell invasion assay//Cell Cycle Assay//Colony Formation Assay The results demonstrated that TPT1‑AS1 knockdown inhibited LC cell proliferation, G1/S transition, migration and invasion compared with the small interfering RNA (si)‑negative control (NC) group. Mechanistically, TPT1‑AS1 knockdown markedly decreased CDK4, N‑cadherin and Vimentin expression levels, but notably increased p21 and E‑cadherin expression levels compared with the si‑NC group. Yes The results demonstrated that TPT1‑AS1 knockdown inhibited LC cell proliferation, G1/S transition, migration and invasion compared with the small interfering RNA (si)‑negative control (NC) group. 34498708 circATP5SL CircRNA Homo sapiens infantile myofibromatosis IH cell Interaction(miR-873-5p/IGF1R ) qRT-PCR Besides, circATP5SL promoted IGF1R expression by directly adsorbing miR-873-5p, an IGF1R inhibitor, thereby promoting cellular invasion, proliferation, and migration as well as inhibition of apoptosis. Yes Besides, circATP5SL promoted IGF1R expression by directly adsorbing miR-873-5p, an IGF1R inhibitor, thereby promoting cellular invasion, proliferation, and migration as well as inhibition of apoptosis. 33841659 hsa_circ_0000437 CircRNA Homo sapiens rheumatic heart disease RVHD Expression [highly expressed] Transfection//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//FISH//Cell Apoptosis Assay//Microarray//Cell Cycle Assay//Transwell Assay Has_circ_0000437 is highly expressed in RVHD (p < 0.001). has_circ_0000437 has the diagnostic value in RVHD. Yes In RVHD, hsa_circ_0000437 can promote cell proliferation and migration but inhibits its apoptosis. 34952991 TRPM2-AS LncRNA Homo sapiens Colorectal Neoplasms cell lines Interaction[TAF15] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Colony Formation Assay//EdU Staining TRPM2-AS was significantly upregulated in CRC cells.This research demonstrated that TRPM2-AS facilitated proliferation of CRC cells by enhancing TAF15-mediated mRNA stability of TRPM2, unmasking the role of TRPM2-AS in CRC. Yes Knock-down of TRPM2-AS inhibited CRC cell proliferation. 31887411 TRPM2-AS LncRNA Homo sapiens gastric adenocarcinoma tumor tissues and GAC cells Interaction(miR-138-5p/ PLAU) Western Blot//Transfection//Migration Assay//Proliferation Assay//qRT-PCR//FISH//Cell Apoptosis Assay//RNA Network//Bioinformatics Analysis After performing quantitative Real-Time polymerase chain reaction or western blotting, we found that the levels of TRPM2-AS and Plasminogen Activator, Urokinase (PLAU) were upregulated in GAC, whereas the level of miR-138-5p was downregulated. Bioinformatic analysis and luciferase assay identified the interaction between TRPM2-AS, miR-138-5p, and PLAU. Yes Cell function experiments proved that silencing TRPM2-AS suppressed proliferation and migration and induced apoptosis in GAC cells. C 34696681 hsa_circ_0005529 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-527/Sp1 axis) In Vivo Experiment//IHC//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our results showed that circ_0005529 was upregulated in GC tissues and cells, and had promoting effects on cell proliferation and cell migration. Mechanism analysis suggested that circ_0005529 could bind to microRNA-527 (miR-527) and reduce its expression. The interaction between miR-527 and Sp1 in GC was systematically studied. In addition, the results indicated that Sp1 upregulation could rescue the effects on cell proliferation and migration caused by circ_0005529. Yes Our results showed that circ_0005529 was upregulated in GC tissues and cells, and had promoting effects on cell proliferation and cell migration. Moreover, the inhibitory effects of circ_0005529 downregulation on GC growth and metastasis were evaluated in mouse models. 33472586 TRPM2-AS LncRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(miR-22-3p and FSTL1) CCK8//qRT-PCR//Wound Healing Assay//Western Blot TRPM2-AS expression in CRC cells was increased, and miR-22-3p expression was decreased in CRC cells. miR-22-3p has a targeting relationship with TRPM2-AS and FSTL1. In cells, downregulation of TRPM2-AS expression promoted miR-22-3p and inhibited FSTL1 expression, while mimics inhibited FSTL1 expression. miR-22-3p inhibition or FSTL1 overexpression could offset the inhibition of TRPM2-AS downregulation on CRC cells. Yes TRPM2-AS inhibition inhibited cell malignant behavior. 36268275 TRPM2-AS LncRNA Homo sapiens Ovarian Neoplasms OvC tissues and cells Interaction(miR-138-5p/SDC3 axis ) qRT-PCR//RNA Pull-Down//RIP//Western Blot Findings indicated that the expression of TRPM2-AS and SDC3 was significantly upregulated in OvC tissues and cells, while miR-138-5p expression was significantly downregulated in OvC samples. It was also found that TRPM2-AS could sponge miR-138-5p to release SDC3, thus promoting OvC progression. Yes Apart from that, we discovered that both sh-TRPM2-AS and cisplatin could enhance the apoptosis of OvC cells. 33621194 TRPM2-AS LncRNA Homo sapiens Urinary Bladder Neoplasms BLCA tissues and cell lines Interaction(miR-22-3p/BLCA) qRT-PCR//RNA Pull-Down Findings indicated that TRPM2-AS was significantly upregulated in BLCA tissues and cell lines. A significant downstream target of TRPM2-AS, miR-22-3p was found to show a lower expression level in BLCA tissues and cell lines. However, the inhibition of miR-22-3p considerably enhanced BLCA cell phenotypes. As well as discovering that GINS2 mRNA was a downstream target of miR-22-3p and was significantly upregulated in BLCA, experimental results also indicated that the knockdown of GINS2 suppressed BLCA cell phenotypes. Yes Apart from that, it was observed that TRPM2-AS knockdown significantly inhibited the viability, proliferation and colony formation of BCLA cells, but it promoted the apoptosis of the BCLA cells. 33658791 TRPM2-AS LncRNA Homo sapiens Esophageal Neoplasms EC tissues and cell lines Interaction(microRNA (miR)-1291, miR-6852-5p, and miR-138-5p expressions) qRT-PCR//Western Blot We found that lncRNA TRPM2-AS expression was increased in EC tissues and cell lines compared with respective control.Furthermore, lncRNA TRPM2-AS knockdown promoted microRNA (miR)-1291, miR-6852-5p, and miR-138-5p expressions. Yes Silencing lncRNA TRPM2-AS suppressed EC cell proliferation, migration, and invasion while promoted cell apoptosis. Moreover, lncRNA TRPM2-AS knockdown reduced neural cadherin, vimentin, and matrix metallopeptidase 9 gene and protein expressions while increased epithelial cadherin expression. 35156509 TRPM2-AS LncRNA Homo sapiens Glioma brain tissues Interaction[JNK, c-Jun, and RGS4] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay The results indicated a significant increase of TRPM2-AS in patients with glioma (2.43 folds of control, p = .0135).The present work indicated the mechanisms of the participation of TRPM2-AS in the progression of gliomas might, at least partly, be related to JNK, c-Jun, and RGS4. Yes MTT methods, wound healing assays, transwell analysis, and clone formation analysis indicated the overexpression of TRPM2-AS promoted the proliferation, migration, and invasion of U251 and U87 cells, while downregulation of TRPM2-AS inhibited the cell proliferation, migration, and invasion significantly (p < .05). 31637708 TRPM2-AS LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cell lines regulation[miR-138/SOX4 axis] qRT-PCR//MTT//Luciferase Report Assay//Western Blot We observed that TRPM2-AS was highly expressed in human LSCC tissues and cell lines. In short, our findings provided first evidence that TRPM2-AS is highly expressed and exerts its oncogenic role in LSCC partly by miR-138/SOX4 axis. LSCC patients with advanced clinical stage exhibited higher intratumoral TRPM2-AS expression. Yes The results of functional assays demonstrated that TRPM2-AS knockdown remarkably inhibited the proliferation, migration and invasion of LSCC cells, whereas TRPM2-AS overexpression showed opposite effects. 32922080 TRPM2-AS LncRNA Homo sapiens Retinoblastoma 35 human RB tissues and RB cell lines Interaction( miR-497/WEE1 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Invasion Assay//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Bioinformatics Analysis//Transwell Assay And, higher TRPM2-AS expression was related to advanced clinical stage and optic nerve invasion in patients. TRPM2-AS acted as a ceRNA for miR-497 to positively regulate WEE1 expression. miR-497 inhibitor or WEE1 overexpression dramatically reversed the effects of TRPM2-AS downregulating on the malignant phenotypes of RB cells. Yes Downregulation of TRPM2-AS significantly inhibited proliferation, migration, and invasion, elevated apoptosis, attenuated G2/M phase arrest in RB cells, and suppressed tumor growth in vivo. 33986660 Trp53cor1 LncRNA Mus musculus Atherosclerosis lesion area of AS Interaction( miR-221/SIRT1/Pcsk9 axis) Western Blot//Wound Healing Assay//Tube Formation Assay//Co-IP//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay miR-221 was highly expressed while SIRT1 was poorly expressed in AS. LincRNA-p21 acted as a sponge for miR-221. miR-221 targeted and negatively regulated the expression of SIRT1. Yes LincRNA-p21 promoted the deacetylation of Pcsk9 by SIRT1 by competitively binding to miR-221, whereby promoting HAEC proliferation, migration and tube formation. 34541816 TRG-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines regulation[miR-4500/BACH1 axis] RNA Pull-Down//RIP//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay TRG-AS1 was conspicuously overexpressed in HCC cells. TRG-AS1 regulates HCC progression by targeting miR-4500/BACH1 axis. Yes TRG-AS1 silencing apparently suppressed HCC cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT). 32774161 Trp53cor1 LncRNA Mus musculus Lipotoxic Kidney Injury n the kidneys of high-fat diet (HFD)-fed mice and tubule cells cultured with palmitic acid (PA) Expression [highly expressed] qRT-PCR//ELISA//IHC//Western Blot In the kidneys of high-fat diet (HFD)-fed mice and tubule cells cultured with palmitic acid (PA), we observed a dramatic upregulation of the long intergenic non-coding RNA-p21 (LincRNA-p21) through a p53-dependent mechanism. Yes Kidney tubule cell-specific deletion of LincRNA-p21 attenuated oxidative stress, inflammation, apoptosis, and endoplasmic reticulum stress, leading to reduction of histological and functional kidney injury despite persistent obesity and hyperlipidemia. 34853727 circGSK3B CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(EZH2 and H3K27me3 ) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Flow Cytometry//qRT-PCR//RIP//FISH//MTT//RNA-seq//IF//Transwell Assay CircGSK3B was mainly identified in the nucleus. This circRNA was present at a reduced concentration in GC tissues and cell lines. Mechanistically, circGSK3B directly interacted with EZH2, acting to suppress the binding of EZH2 and H3K27me3 to the RORA promoter, and leading to an elevation in RORA expression and ultimately the suppression of GC progression. Yes Overexpression of circGSK3B was shown to inhibit the growth, invasion, and metastasis of GC cells both in vitro and in vivo. 34666800 circVPS33B CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-873-5p/HNRNPK Axis ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay CircVPS33B was upregulated in infiltrative GC tissues and cells. Mechanically, circVPS33B regulated heterogeneous nuclear ribonucleoprotein K (HNRNPK) expression via sponging miR-873-5p. Furthermore, miR-873-5p inhibitor offset circVPS33B knockdown-mediated effects on malignant behaviors and Warburg effect of infiltrative GC cells. HNRNPK overexpression reversed the inhibitory impact of miR-873-5p mimic on malignant behaviors and Warburg effect of infiltrative GC cells. Yes CircVPS33B silencing decreased tumor growth in vivo and inhibited proliferation, migration, invasion, EMT, and Warburg effect of infiltrative GC cells in vitro. 34012268 TRIM52-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-218-5p/ROBO1) CCK8//qRT-PCR//Colony Formation Assay//RIP TRIM52-AS1 was overexpressed in HCC according to the TCGA database and RT-qPCR assay. TRIM52-AS1 could act as competitive endogenous RNA to regulate ROBO1 through miR-218-5p, then promoted the HCC cell progression. The expression of TRIM52-AS1 was higher in the metastatic foci compared with primary tumor according to the GEO database. Yes Additionally, TRIM52-AS1 knockdown inhibited the proliferation and metastasis of HCC cells. 33519234 TRIM52-AS1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL cell lines Interaction( IGFBP3/miR-218-5p/TRIM52 axis) RNA Pull-Down//IP//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//EdU Staining The experimental results confirmed the overexpression of TRIM52-AS1 in the DLBCL cell lines. Interestingly, the overexpression of TRIM52-AS1 increased the mRNA stability of TRIM52 through binding IGFBP3 protein and upregulated the TRIM52 protein expression by sponging miR-577. Together, the overexpressed TRIM52-AS1 could promote the DLBCL progression through IGFBP3/miR-218-5p/TRIM52 axis, highlighting the clinical significance of TRIM52-AS1 in the DLBCL diagnosis. Further, the high expression of TRIM52-AS1 predicted the poor Ann Arbor stage and were correlated with the presence of B symptoms, high international prognostic index, and poor disease prognosis. Yes TRIM52-AS1 knockdown inhibited the DLBCL cell proliferation, and induced apoptosis and G0/G1 cycle arrest. 35676608 circRNF220 CircRNA Homo sapiens childhood acute myeloid leukemia peripheral blood and bone marrow of pediatric patients with AML Interaction(miR-30a/MYSM1 and IER2 Axis) RNA Pull-Down//CCK8//qRT-PCR//FISH//RNA-seq//Cell Apoptosis Assay//Microarray//Cell Cycle Assay We identified a circRNA, circRNF220, which was specifically abundant in and accumulated in the peripheral blood and bone marrow of pediatric patients with AML. Mechanistically, circRNF220 may act as an endogenous sponge of miR-30a to sequester miR-30a and inhibit its activity, which increases the expression of its targets MYSM1 and IER2 and implicated in AML relapse. It could distinguish AML from ALL and other hematological malignancies with high sensitivity and specificity. Significantly, circRNF220 expression independently predicted prognosis, while high expression of circRNF220 was an unfavorable prognostic marker for relapse. Yes Furthermore, we characterized the function of circRNF220 and found that circRNF220 knockdown specifically inhibited proliferation and promoted apoptosis in AML cell lines and primary cells. 34702297 TRHDE-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Regulation[miRNA-103/KLF4 axis ] CCK8//Luciferase Report Assay//Western Blot//Transwell Assay "To determine the role of TRHDE‐AS1 in lung cancer, we examined the expression of TRHDE‐AS1 in 41 normal lung tissues and lung cancer tissues, and TRHDE‐AS1 had significantly decreased expression levels in the lung cancer tissues compared with those in the normal tissues.In summary, we determined that the effects of TRHDE-AS1 on proliferation, invasion, and cell death could be rescued by the overexpression of miR-103. Our experiments demonstrate that the TRHDE-AS1/miR-103/KLF4 axis may provide new evidence for understanding the molecular basis of lung cancer." Yes Our results demonstrated that the lncRNA TRHDE-AS1 is mainly located in the cytoplasm and that the cell proliferation and invasion were suppressed in the group of overexpressed TRHDE-AS1. 31119790 TRG-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues or cells Interaction(miR-224-5p/SMAD4 axis ) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//IHC//Transwell Assay The results showed that TRG-AS1 was highly upregulated and miR-224-5p was downregulated in lung cancer. A negative correlation was found between TRG-AS1 and miR-224-5p. The downstream protein SMAD4 played an important role. In vivo study showed that knockdown of TRG-AS1 effectively retarded tumor growth. Yes Furthermore, upregulation of TRG-AS1 promoted cell proliferation and invasion, while overexpression of miR-224-5p attenuated the effects of TRG-AS1. 34408438 TMPO-AS1 LncRNA Homo sapiens Colorectal Neoplasms cell lines interaction[targeting miR-143-3p] qRT-PCR//MTT//Transwell Assay//Western Blot TMPO?AS1 expression was increased and miR?143?3p expression was decreased in CRC cells. It was concluded that TMPO‑AS1 regulated cell proliferation, migration and invasion of CRC cells by targeting miR‑143‑3p. Yes TMPO?AS1 knockdown and miR?143?3p overexpression significantly inhibited cell proliferation, migration and invasion of CRC cells. 32945436 TMPO-AS1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer cells Interaction(miR-98-5p) CCK8//qRT-PCR//Western Blot TMPO-AS1 was aberrantly expressed at high levels in colorectal cancer cells. Furthermore, miR-98-5p was proven to a target of TMPO-AS1 inhibit cell progression in colorectal cancer. Additionally, BCAT1 was proved to enhance cell progression as the target of miR-98-5p, and it offset the effect of silenced TMPO-AS1 on colorectal cancer cells. Yes Silenced TMPO-AS1 restrained cell proliferation and stemness and promoted apoptosis oppositely, while overexpressing TMPO-AS1 exerted the adverse effects. 34370878 TMPO-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[miR-429/GOT1 Axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay In this study, our findings revealed that TMPO-AS1 expression was upregulated in HCC tissues and cell lines. Taken together, these findings indicated that TMPO-AS1 acted as a tumor motivator to expedite HCC progression via targeting miR-429/GOT1 axis, which may provide a fresh treatment strategy for HCC. Yes TMPO-AS1 aggravated HCC progression via promoting cell proliferation, stemness as well as suppressing cell apoptosis. 32988599 circFNDC3B CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck tissues and cell lines Interaction(miR-1322/MED1 axis) In Vivo Experiment//RNA Pull-Down//Luciferase Report Assay The level of circFNDC3B in tissues or cell lines of OTSCC was higher than that in control groups. circFNDC3B directly bound with miR-1322 and consequently promoted the MED1 expression in OTSCC cells. Yes siRNA-mediated circFNDC3B inhibition resulted in weakened proliferation, migration, and invasion, which was reversed by miR-1322. Overexpression of MED1 in OTSCC cells partially reversed the tumor suppression functions of si-circFNDC3B or miR-1322 mimics in vitro. circFNDC3B overexpression dramatically promoted tumor growth in vivo. 35916453 TDRG1 LncRNA Homo sapiens Diabetic Retinopathy epiretinal membranes Regulation[upregulating VEGF ] qRT-PCR//migration assay//Western Blot LncRNA TDRG1 and VEGF were found to be co-expressed and significantly upregulated in fibrovascular membranes (FVMs) from DR patients compared to those from EM patients. Yes In the in vitro model, hyperglycemic treatment markedly increased the expression of lncRNA TDRG1 and VEGF at the mRNA and protein levels, which promoted cell proliferation and migration, enhanced permeability, and disrupted tube formation of HRECs. However, knockdown of lncRNA TDRG1 or VEGF notably decreased the expression of VEGF and reversed the impaired functions of high-glucose-treated HRECs. 32082175 TCTN2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues and cell lines Interaction(mIR-1285-3p/ARF6 Axis) qRT-PCR//Luciferase Report Assay LncRNA TCTN2 exhibited a high expression in HCC tumor tissues and cell lines. Mechanistic investigation revealed that lncRNA TCTN2 upregulated the expression of ARF6 via sponging miR-1285-3p. Rescue experiments indicated that miR-1285-3p inhibitor reversed the antitumor effects of lncRNA TCTN2 and ARF6 knockdown inhibited the progression of HCC. Yes Knockdown of lncRNA TCTN2 suppressed cell proliferation and induced cell cycle arrest and apoptosis through regulating Cyclin D1/p21 and Bax/Bcl-2 signals. Meanwhile, the knockdown of lncRNA TCTN2 inhibited HCC cell migration and invasion through upregulating MMP2/MMP9. 36278455 TCRG1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction[modulate MAPK1 by sponging miR-326] RNA Pull-Down//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of TDRG1 was significantly increased in CC tissues and cell lines compared with normal tissue and normal cell line respectively and its expression was associated with clinicopathological characteristics of CC patients. TDRG1 acts as a competing endogenous lncRNA (ceRNA) to modulate MAPK1 by sponging miR-326 in CC, shedding new light on TDRG1-directed diagnostics and therapeutics in CC. The expression of TDRG1 was significantly increased in CC tissues and cell lines compared with normal tissue and normal cell line respectively and its expression was associated with clinicopathological characteristics of CC patients. Yes Knockdown of TDRG1 inhibited the cell proliferation, migration and invasion in Hela and SIHA cells. 31164797 TCONS_00068220 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell line Regulation(E-cadherin) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//Cell Viability Assay//Invasion Assay TCONS_00068220 was remarkably upregulated in breast cancer tissues compared with non-cancerous tissues. All breast cancer cell lines displayed a higher expression level of TCONS_00068220 compared with the normal breast epithelial cell line MCF-10A. E-cadherin was negatively regulated by TCONS_00068220 in both breast cancer tissues and cell lines. Finally, TCONS_00068220 regulated MCF-7 and MDA-MB-231 cell behaviors by downregulating E-cadherin. In addition, TCONS_00068220 level was significantly correlated with lymphatic metastasis, Ki67 index, clinical stage, and differentiation grade. Yes Furthermore, enhanced expression of TCONS_00068220 in MCF-7 cells promoted cell proliferation, migration, invasion, and EMT, whereas TCONS_00068220 knockdown in MDA-MB-231 cells led to the opposite results. E-cadherin was negatively regulated by TCONS_00068220 in both breast cancer tissues and cell lines. 33716295 TCONS_00041002 LncRNA Rattus norvegicus Hypoxia-Ischemia, Brain brains of HI rats Expression(highly expressed) Tunel//CCK8//qRT-PCR//MTT//H&E Staining//IF Among them, three lncRNAs (TCONS_00041002, TCONS_00070547, TCONS_00045572) were enriched in the apoptotic process via gene ontology (GO) and pathway analysis, which were selected for the further qRT-PCR verification. Through lentivirus-mediated overexpression of these three lncRNAs, we found that overexpression of TCONS_00041002 attenuated the cell apoptosis, and increased the vitality of neurons after oxygen-glucose deprivation (OGD), therefore reduced the brain infarction and further promoted the neuron survival as well as improved the neurological disorders in the rats subjected to HIE. What's more, ceRNA network prediction and co-expression verification showed that the expression of TCONS_00041002 was positively associated with Foxe1, Pawr and Nfkbiz. Altogether, this study has exhibited that lncRNA TCONS_00041002 participates in the cell apoptosis and neuronal survival of HIE and represents a potential new target for the treatment of HIE. Yes Through lentivirus-mediated overexpression of these three lncRNAs, we found that overexpression of TCONS_00041002 attenuated the cell apoptosis, and increased the vitality of neurons after oxygen-glucose deprivation (OGD), therefore reduced the brain infarction and further promoted the neuron survival as well as improved the neurological disorders in the rats subjected to HIE. What's more, ceRNA network prediction and co-expression verification showed that the expression of TCONS_00041002 was positively associated with Foxe1, Pawr and Nfkbiz. 34390705 hsa_circ_0082835 CircRNA Homo sapiens Melanoma, Cutaneous Malignant clinical melanoma samples Interaction(microRNA miRNA-429) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay As a result, the expression of circRNA_0082835 was increased and that of miR-429 was decreased with the increase in lymphatic metastasis level. Yes Inhibiting circ_0082835 and EZH2 suppressed the proliferation, invasion and migration, regulated the cell cycle levels, inhibited Wnt/β-catenin and attenuated EMT in melanoma cells. Inhibition of circ_0082835 and/or EZH2 elevated miR-429 expression. 34288815 circBCBM1 CircRNA Homo sapiens Breast Cancer Brain Metastasis breast cancer brain metastasis cells and clinical tissue and plasma samples Expression [highly expressed] qRT-PCR//FISH Functionally, circBCBM1 promoted the proliferation and migration of 231-BR cells in vitro and growth and brain metastasis in vivo. Mechanistically, circBCBM1 acted as an endogenous miR-125a sponge to inhibit miR-125a activity, resulting in the upregulation of BRD4 (bromodomain containing 4) and subsequent upregulation of MMP9 (matrix metallopeptidase 9) through Sonic hedgehog (SHH) signaling pathway. Importantly, circBCBM1 was markedly upregulated in the breast cancer brain metastasis cells and clinical tissue and plasma samples; besides, circBCBM1 overexpression in primary cancerous tissues was associated with shorter brain metastasis-free survival (BMFS) of breast cancer patients. Yes Functionally, circBCBM1 promoted the proliferation and migration of 231-BR cells in vitro and growth and brain metastasis in vivo. 34421353 circFAT1 CircRNA Homo sapiens Carcinoma, Squamous Cell Head and neck squamous cell carcinoma tumors and adjacent normal tissues Expression [highly expressed] qRT-PCR Here, it is reported that elevated circular RNA FAT1 (circFAT1) in squamous cell carcinoma (SCC) unifies and regulates the positive association between cancer stemness and immune evasion by promoting STAT3 activation. circFAT1 knockdown (KD) reduces tumorsphere formation of SCC cells in vitro and tumor growth in vivo. Bioinformatic analysis reveals that circFAT1 KD impairs the cancer stemness signature and activates tumor cell-intrinsic immunity. The Kaplan–Meier survival analysis showed significantly shorter overall survival times of HNSCC patients with elevated expression levels of circ_0000231, circFAT1, and circ_0001742 compared with patients with low expression levels Yes circFAT1 knockdown (KD) reduces tumorsphere formation of SCC cells in vitro and tumor growth in vivo. 34258151 circSnap47 CircRNA Homo sapiens Heart Failure HF tissues and H9C2 cells Interaction(miR-223-3p/MAPK axis) Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//ELISA//Bioinformatics Analysis In HF tissues and H9C2 cells treated with oxygen-glucose deprivation (OGD), circSnap47 was upregulated. Moreover, we found that miR-233-3p was the downstream target gene of circSnap47. Our results also revealed that silencing circSnap47 relieved OGD-induced H9C2 cell damage by inactivating the miR-223-3p/MAPK axis. Yes Silencing circSnap47 increased cell viability and inhibited apoptosis. Besides, silencing circSnap47 alleviated OGD-induced inflammation in H9C2 cells. 35900666 TDRG1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell and tissues Interaction(miR-214-5p/KLF5 axis) Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay In this study, we found that TDRG1 was upregulated in NSCLC samples. In addition, TDRG1 interacted with miR-214-5p, and miR-214-5p directly targeted KLF5. The suppressive effect of TDRG1 knockdown on NSCLC cellular processes was abolished by KLF5 overexpression. Overall, TDRG1 exerts carcinogenic effects in NSCLC by regulating the miR-214-5p/KLF5 axis. Yes unctionally, TDRG1 depletion inhibited NSCLC cell growth, migration, and invasion and accelerated apoptosis. 34856848 circAP2A2 CircRNA Homo sapiens Hemangioma IH tissues and cell lines regulation[miR-382-5p/VEGFA axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay CircAP2A2 was confirmed to be highly expressed in IH.CircAP2A2 could promote proliferation and invasion of IH by regulating miR-382-5p/VEGFA axis. Yes CircAP2A2 knockdown or miR-382-5p overexpression decreased the proliferation, colony formation, migration, and invasion of HemECs and HUVEC cells. 32091151 hsa_circ_0062166 CircRNA Homo sapiens Cerebral Ischaemia/Reperfusion Injury neuro-2A (N2A) neuroblastoma cells Interaction(miR-526b-5p/BCL2L13 axis) RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay Circ_0062166 was significantly up-regulated in neuro-2A (N2A) neuroblastoma cells following OGD/R.From the perspective of mechanism, circ_0062166 functioned as a competing endogenous RNA (ceRNA) for microRNA-526b-5p (miR-526b-5p) and regulated BCL2 like 13 (BCL2L13). Eventually, the promoting role of the circ_0062166/miR-526b-5p/BCL2L13 axis in the CIR injury was verified. Yes Functionally, the silencing of circ_0062166 inhibited cell proliferation and promoted cell apoptosis under OGD/R condition. 34495821 circTASP1 CircRNA Homo sapiens acute myeloid leukemia AML peripheral blood samples and cells Interaction(miR-515-5p/HMGA2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//FISH//RIP//qRT-PCR//Luciferase Report Assay//Microarray//Cell Cycle Assay//IHC//EdU Staining In this study, we showed that circTASP1 was significantly up-regulated in AML peripheral blood samples and cells.Bioinformatics prediction and luciferase reporter assay proved that circTASP1 sponged miR-515-5p and negatively regulated miR-515-5p expression in HL60 and THP-1 cells. High mobility group A2 (HMGA2) was proved to be a downstream target of miR-515-5p. The rescue experiments confirmed that knockdown of circTASP1 inhibited proliferation and induced apoptosis by modulating miR-515-5p/HMGA2 pathway. Yes Knockdown of circTASP1 inhibited proliferation and promoted apoptosis of HL60 and THP-1 cells in vitro. 34197029 TCONS_00026334 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[miR-548n/TP53INP1 signaling pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results indicated that TCONS_00026334 expression in 86 CRC tissues was markedly lower than that in non-cancerous tissues.Taken together, our study showed that TCONS_00026334 acts as an anti-tumor and anti-metastatic gene by regulating the miR548n/TP53INP1 axis in the development of CRC. The aberrant expression of TCONS_00026334 correlated negatively with larger tumor size, distant metastasis, serological carcinoembryonic antigen level, and unfavorable survival of patients with CRC. Yes TCONS_00026334 overexpression could inhibit the aggressive phenotypes of CRC in vitro and in vivo. Conversely, TCONS_00026334 silencing accelerated CRC cell proliferation and invasion. 32986920 circHIPK3 CircRNA Homo sapiens Spinal Cord Injuries OGD-induced AGE1.HN cells Interaction(miR-382-5p/DUSP1 axis ) Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//ELISA CircHIPK3 and DUSP1 were down-regulated, while miR-382-5p was up-regulated in OGD-induced AGE1.HN cells.CircHIPK3 regulated DUSP1 expression by targeting miR-382-5p. MiR-382-5p inhibition hindered inflammatory response of IL-6 and TNF-α and neuronal apoptosis and promoted apoptosis via targeting DUSP1. Yes Overexpression of circHIPK3 suppressed inflammatory response and cell apoptosis and promoted proliferation in OGD-induced AGE1.HN cells by sponging miR-382-5p. 35500847 circUsp10 CircRNA Homo sapiens Spinal Cord Injuries neuronal cell line HT22 Interaction(miRNA-152-5p/CD84) In Vivo Experiment//Transfection//qRT-PCR//RNA-seq//Luciferase Report Assay//ELISA//Bioinformatics Analysis The circ-Usp10/miR-152-5p/CD84 axis was found to function in microglial activation. Taken together, we concluded that circ-Usp10 may function as a competing endogenous RNA (ceRNA) to promote microglial activation and induce neuronal death by targeting miR-152-5p/CD84. Yes We also found that circ-Usp10 inhibited the secretion of proinflammatory factors in microglial BV2 cells. In addition, silencing circ-Usp10 significantly reduced the death of the neuronal cell line HT22. 34753388 circHIPK3 CircRNA Homo sapiens Carcinoma, Renal Cell CCRCC tissues Expression[lower expressed] qRT-PCR Furthermore, we found that circHIPK3 was downregulated in CCRCC tissues and cell lines. Yes Overexpression of circHIPK3 effectively suppressed CCRCC cell invasion and migration in vitro, and inhibited CCRCC cell proliferation in vitro and in vivo. 32409849 TCONS_00020456 LncRNA Homo sapiens Glioblastoma glioma tissues Interaction[Smad2/PKCα signal pathway] Western Blot//Wound Healing Assay//FISH//Microarray//Invasion Assay//Transwell Assay LncRNA TCONS_00020456 was targeted for further study; TCONS_00020456 was one of the most downregulated lncRNAs in microarray analysis and PCR validation. Taken together, TCON, regarded as oncosuppressor, targeting the Smad2/PKCα axis plays a novel role in inhibiting the malignant progression of glioma. Yes Overexpression of TCON reduced the proliferation on one hand and migration, invasion on the other. TCON also inhibited epithelial-mesenchymal transformation and glioma progression in vivo, based on a nude mouse tumorigenicity assay. 31603255 TDRG1 LncRNA Homo sapiens stomach carcinoma gastric carcinoma tissues,cell line Regulation[miR-873-5p/HDGF axis] qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay In this study, we demonstrated that lncRNA testis development-related gene 1 (TDRG1) is markedly Expression[Expression[up-expression]-expression]regulated in clinical GC tissues and GC cells.We future find that TDRG1 is inversely associated with miR-873-5p and positively modulates the expression of hepatoma-derived growth factor (HDGF), a functional target gene of miR-873-5p. Finally, lncRNA TDRG1 regulates the progression of GC through regulating miR-873-5p/HDGF pathway. High level of lncRNA TDRG1 correlates with the metastasis and prognosis of patients with GC. Yes Overexpression of lncRNA TDRG1 promotes GC growth and metastatic-related traits in vitro and in vivo, and silencing TDRG1 causes opposite results. 31726370 TDRG1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC and normal tissues interaction[miR-214-5p,SOX4] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The results showed that expression of TDRG1 was up-regulated, while that of miR-214-5p was down-regulated in CC. In conclusion, TDRG1 acts as cancer promoter in CC through promoting cell proliferation, migration, invasion, and EMT process to modulate SOX4 expression through adsorbing miR-214-5p. Yes Knocking down TDRG1 expression could inhibit cell proliferation, colony, migration, and invasion abilities, and EMT process, whereas the inhibition of miR-214-5p expression partially reversed such results. 32106739 hsa_circ_0000848 CircRNA Homo sapiens Fetal Growth Retardation FGR placenta interaction[Sponging hsa-miR-6768-5p] qRT-PCR//RIP//Western Blot RT-qPCR results showed that hsa_circ_0000848 expression was significantly down-regulated in FGR placenta. hsa_circ_0000848 promotes trophoblast cell migration and invasion, and inhibits cell apoptosis via the sponging of hsa-miR-6768-5p. Yes Hsa_circ_0000848 overexpression and hsa-miR-6768-5p inhibitor suppressed apoptosis, and promoted cell migration and invasion. 32509771 TFAP2A-AS1 LncRNA Homo sapiens Lung Neoplasms NSCLC cell Interaction(microRNA 548a 3p/CDK4 axis) qRT-PCR An increased TFAP2A AS1 level displayed a negative correlation with the overall survival of patients with NSCLC. Mechanistically, TFAP2A AS1 could negative regulate microRNA 584 3p (miR 584 3p) as a competitive endogenous RNA. Furthermore, cyclin dependent kinase 4 (CDK4), a direct target of miR 584 3p, was positively controlled by TFAP2A AS1 in a miR 5184 3p dependent manner. Rescue function experiments corroborated that the anticancer activities of TFAP2A AS1 deficient on the oncogenicity of NSCLC cells were reversed by downregulating miR 584 3p or overexpressing CDK4. An increased TFAP2A AS1 level displayed a negative correlation with the overall survival of patients with NSCLC. Yes Loss of function approaches illustrated that the absence of TFAP2A AS1 weakened NSCLC cell proliferation, colony formation, migration and invasion in vitro. Also, interference of TFAP2A AS1 caused in vivo tumor growth suppression. 35641154 TGFBR2 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissue samples Interaction(miR-107) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//IF//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay . Furthermore, the expression of circTGFBR2 was downregulated in NPC tissue samples, while circTGFBR2 overexpression correlated with favorable prognosis in NPC. Further analysis showed that circTGFBR2 sponged miR-107, leading to the upregulation of TGFBR2 expression and suppression of NPC progression. . Furthermore, the expression of circTGFBR2 was downregulated in NPC tissue samples, while circTGFBR2 overexpression correlated with favorable prognosis in NPC. Yes Functionally, circTGFBR2 overexpression inhibited the proliferation and migration of NPC cells both in vitro and in vivo. 33160003 TGFB2-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms BCSC Regulation(TGFβ2 ) ChIP-seq Mechanistically, TGFB2-AS1 interacts with SMARCA4, a core subunit of the SWI/SNF chromatin remodeling complex, and results in transcriptional repression of its target genes including TGFB2 and SOX2 in an in cis or in trans way, leading to inhibition of transforming growth factor β (TGFβ) signaling and BCSC characteristics. Yes We revealed that TGFB2-AS1 impairs the breast cancer stem-like cell (BCSC) traits of TNBC cells in vitro and dramatically decreases tumorigenic frequency and lung metastasis in vivo. 36126099 TGFB2-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells regulation[TGFB2-AS1/miR-340-5p/EDNRB axis] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay Results indicated TGFB2-AS1 was evidently downregulated in LUAD tissues and cells.Collectively, our results indicated TGFB2-AS1/miR-340-5p/EDNRB axis plays crucial roles in regulating LUAD progression, indicating TGFB2-AS1 may be a novel therapeutic target for LUAD. Yes Moreover, as analyzed by cell counting kit-8 assay, wound-healing and transwell invasion assays, results revealed TGFB2-AS1 overexpression could suppress proliferation, migration and invasion abilities of LUAD cells in vitro and tumor growth in vivo. 32774737 TFF3-202 LncRNA Homo sapiens Thyroid Cancer, Papillary cell lines Interaction[Regulating MiR-922] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay The expression of ENST00000489676 was significantly overexpressed in TPC1 compared to KTC1 cell lines. Yes When ENST00000489676 expression was knocked down, the proliferation, migration and invasion ability as well as cell cycle were all promoted in PTC cell lines, while those abilities were all suppressed when ENST00000489676 overexpressed. Overexpression of ENST00000489676 could inhibit cell proliferation, migration and invasion in vitro. Moreover, ENST00000489676 may mediate tumor suppression in PTC cells through suppressing miR-922. 31632488 TFF1 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues regulation[miR-326/TFF1 signalling] Western Blot//qPCR//RIP//PCR//Microarray//IP//IF Circ-TFF1 and TFF1 were both upregulated and positively associated with each other in breast cancer. Circ-TFF1 is a facilitator in breast cancer relying on TFF1 by absorbing miR-326, providing a novel promising target for BC treatment. Yes Knockdown of circ-TFF1 hindered breast cancer cell proliferation, migration, invasion and EMT in vitro and controlled tumour growth in vivo. 31961997 TFDP1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Regulation[STAT3 signaling] Western Blot//Migration Assay//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Invasion Assay In the present study, we for first found that lnc-DILC was downregulated in human bladder cancer tissues.Taken together, our results suggest that lnc-DILC is a novel bladder tumor suppressor and indicate that lnc-DILC inhibits BC progression via inactivating STAT3 signaling. Yes Lnc-DILC overexpression suppressed the proliferation, metastasis and expansion of bladder cancer stem cells (CSCs). 31176734 TFAP2A-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Regulation[miR-933/SMAD2 axis ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay TFAP2A-AS1 expression was significantly lower in BC tissues and cell lines.TFAP2A-AS1 was revealed to act as a miRNA sponge for miR-933 and then regulated the expression of Smad2. CONCLUSIONS Results from the present study suggest that TFAP2A-AS1 acts as a tumor suppressor in BC via the miR-933/SMAD2 axis. Yes Overexpression of TFAP2A-AS1 in BC cells caused cell cycle arrest, promoted cell apoptosis, suppressed cell ability, and attenuated cell invasion in vitro, and inhibited tumor growth in vivo. 30768589 TFAP2A-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC samples and cells Expression(highly expressed) qRT-PCR//Wound Healing Assay//Colony Formation Assay//Transwell Assay The consequences displayed that TFAP2A-AS1 was upregulated in the TCGA datasets.The expression of TFAP2A-AS1 was higher in OSCC samples. Bioinformatics analysis shown that TFAP2A-AS1 might be associated with the P53 signaling pathway. Yes Cell culture experiments indicated that deficiency of TFAP2A-AS1 inhibited cell growth, invasion, and migration, and overexpression of it could opposite results in SCC-25 cells. 35524329 TEX41 LncRNA Homo sapiens B-cell acute lymphoblastic leukemia pediatric B-ALL patients Expression(highly expressed) Cell Proliferation Assay//Flow Cytometry//Western Blot We exploited the St Jude Cloud database and found that TEX41 is a lncRNA primarily expressed in the case of B-ALL (n = 79) while its expression levels are low/absent for T-cell ALL (n = 25) and acute myeloid leukemia (n = 38). TEX41 disclosed increased expression levels in bone marrow from patients with B-ALL at diagnosis, while its expression levels became low or absent when retested in Bone Marrow cells of the same patient after 1 month of induction therapy. Yes Also, silencing experiments performed on RS4;11 cells showed that TEX41 downregulation impaired in vitro leukemic cell growth determining their arrest in the G2-M phase and the deregulation of cell cycle proteins. 34233751 TDRG1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues regulation[PI3K/AKT Signal Pathway] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay TDRG1 was highly expressed in osteosarcoma, and the levels of p-PI3K and p-AKT were also up-regulated.TDRG1 is highly expressed in osteosarcoma tissue. Silencing the expression of osteosarcoma can inhibit the proliferation, invasion, migration and EMT of osteosarcoma cells by inhibiting PI3K/AKT signaling pathway, which may be a new target for diagnosis and treatment of osteosarcoma. Yes Cell experiments showed that inhibiting the expression of TDRG1 could inhibit the proliferation, invasion, migration and EMT of osteosarcoma cells, promote the apoptosis of cells, and up-regulating the expression of TDRG1 could promote the proliferation, invasion, migration and EMT of osteosarcoma cells and inhibit the apoptosis of cells. 32606946 TERC LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues Interaction( miR-423-5p/SOX12 signaling axis) Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay The results demonstrated that the lncRNA TERC expression levels were upregulated in GC cells and tissues, while miR-423-5p expression levels were downregulated. In conclusion, the findings of this study suggested that the lncRNA TERC may regulate the miR-423-5p/SOX12 signaling axis by directly sponging miR-423-5p and inhibiting SOX12 expression, thereby leading to the progression of GC. These findings may reveal novel targets for future GC therapy. The upregulation of the lncRNA TERC was associated with a shorter overall survival in patients with GC. Yes The knockdown of the lncRNA TERC significantly reduced the proliferation, migration, and invasion of human GC cell lines HGC-27 and SNU-1 cells. 36267723 TERC LncRNA Homo sapiens Osteoporosis serum regulation[miRNA-217 ,RUNX2] qRT-PCR//Luciferase Report Assay//Western Blot The downregulated TERC and upregulated miRNA-217 were identified in the serum of the OP patients. The serum level of TERC is lowly expressed in OP patients. TERC influences hMSCs osteogenesis by absorbing miRNA-217 to upregulate RUNX2, thus alleviating the progression of OP. Yes The silence of TERC, or RUNX2 downregulated ALP and RUNX2 levels, decreased ALP activity and attenuated the calcification ability in hMSCs. 32016954 TDRKH-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[Wnt Signaling Pathway] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay We found that TDRKH-AS1 is upregulated in majority of CRC patients, which is also significantly correlated with their malignant characteristics and their dismal prognoses. We also recognized that the TDRKH-AS1 targets the β-catenin in the Wnt signaling pathway to exert its carcinogenic activity. Yes The high expression of TDRKH-AS1 can promote cancer cell proliferation substantially and invasion based on in vitro experiments. 32670860 TDRG1 LncRNA Homo sapiens Breast Neoplasms BC cell lines Interaction(miR-214-5p/CLIC4 axis) In Vivo Experiment//RNA Pull-Down//CCK8//qRT-PCR//FISH//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay TDRG1 was remarkably overexpressed in BC cell lines. Mechanistically, TDRG1 acted as a miR-214-5p sponge to up-regulate CLIC4 expression. Yes TDRG1 knockdown suppressed cell proliferation, migration and invasion, but enhanced BC cell apoptosis. 33822672 TDRG1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation[ miR-873-5p/ZEB1 axis ] qRT-PCR Here, we demonstrate that TDRG1 is significantly overregulated in NSCLC tissues and cell lines.Altogether, lncRNA TDRG1 facilitates the progression of NSCLC via interacting with miR-873-5p and positively regulates the expression of ZEB1. Yes Knockdown of TDRG1 inhibits the proliferation and metastatic-related traits of NSCLC cell in vitro whereas overexpression of TDRG1 causes opposite results. In addition, TDRG1 silencing inhibits the growth and metastatic ability of NSCLC cell in vivo as demonstrated by xenograft tumor model and lung metastasis model. 31742752 TDRG1 LncRNA Homo sapiens Lung Neoplasms 3D non-adherent spheres as the CSC model Interaction(Sox2 mRNA) qRT-PCR//MTT//Western Blot In the present study, we collected 3D non-adherent spheres as the CSC model to measure lncRNA TDRG1 level in lung CSC and the parental lung cancer cells, and found that TDRG1 level was significantly upregulated in lung CSCs compared to that of parental lung cancer cells.Mechanistically, we identified that TDRG1 directly bound to Sox2 mRNA, which is a critical stemness regulator, enhanced its mRNA stability, and thus increased Sox2 expression. Yes It was found that TDRG1 positively regulated lung cancer stemness. 36444968 TDRG1 LncRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(miR-873-5p to upregulate PRKAR2) qRT-PCR//Western Blot//FISH Here, we found that TDRG1 level was upregulated in CRC cells compared to that in normal colon epithelial cells.Additionally, TDRG1 level was remarkably upregulated in 3D non-adherent spheres derived from the parental CRC cells.What's more, combined with bioinformatics analysis, luciferase reporter and RNA pull down experiments showed that TDRG1 could bind to miR-873-5p, downregulated its level and thus increase the expression of PRKAR2. Yes Further in vitro and in vivo revealed that TDRG1 knockdown suppressed the stemness of CRC cells. 35730470 TCONS_00019174 LncRNA Rattus norvegicus Depressive Disorder mice exposed to chronic ultra-mild stress Interaction(p-GSK3β and β-catenin) In Vivo Experiment We found that mice exposed to chronic ultra-mild stress displayed apparent depression-like behaviors and decreased expression of long non-coding RNA TCONS_00019174 in hippocampus. Further, it was found long non-coding RNA TCONS_00019174 over expression upregulated phosphorylated-GSK3β (p-GSK3β) protein and β-catenin in the hippocampus. Yes Viral-mediated long non-coding RNA TCONS_00019174 over expression in hippocampal neurons improved the behaviors of mice exposed to chronic ultra-mild stress. 29036835 circFIG4 CircRNA Homo sapiens Esophageal Neoplasms EC cells Interaction(miR-493-5p/E2F3 axis) In Vivo Experiment//IHC//Western Blot//Transfection//Wound Healing Assay//Invasion Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay circFIG 4 was overtly upregulated in EC and was relatively stable in EC cells. circFIG 4 served as a miR-493-5p sponge to act in the development of EC. Furthermore, circFIG 4 modulated EC progression via targeting miR-493-5p and miR-493-5p suppressed EC progression via targeting E2F3. circFIG 4 modulated E2F3 expression through acting as a sponge of miR-493-5p. Moreover, circFIG 4 knockdown inhibited EC tumorigenesis by targeting miR-493-5p/E2F3 axis tumor growth in vivo. Yes circFIG 4 knockdown impeded proliferation, migration, and invasion and expedited apoptosis in EC cells. 35083866 TMPO-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines regulation[miR-320a/SERBP1 Axis] Western Blot//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Currently, we revealed that TMPO-AS1 was overexpressed in clinical HCC samples and a panel of HCC cell lines. Further studies revealed that lncRNA TMPO-AS1 was largely located in the cytoplasm of HCC cell and sponge miR-320a, resulting in increasing the level of SERBP1 in HCC cell. Clinically, a higher level of TMPO-AS1 was connected to the advanced stage of HCC and worse prognosis of patients. Yes Depletion of TMPO-AS1 repressed HCC cell viability, migration ability and invasiveness. Nevertheless, upregulation of TMPO-AS1 caused opposite results. 32753892 circTAOK1 CircRNA Homo sapiens Diabetic Nephropathies exosomes Interaction(miR-520h/SMAD3 axis) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//EdU Staining CircTAOK1 expression was upregulated in the exosomes isolated from HG-treated glomerular epithelial cells (GEC). Mechanically, circTAOK1 could regulate SMAD3 expression by sponging miR-520h, GEO-si-circTAOK1 Exo-induced miR-520h and repressed SMAD3 expression in GMC. Yes Moreover, GEC-circTAOK1-Exo could promote proliferation, fibrosis, and epithelial-mesenchymal transition (EMT) of glomerular mesangial cells (GMCs). 35142978 hsa_circ_102049 CircRNA Homo sapiens Colorectal Liver Metastasis primary CRC tumors with liver metastasis Interaction(micro (mi)R-761/miR-192-3p-FRAS1-dependent) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//FISH//RIP//Microarray//Colony Formation Assay//Bioinformatics Analysis We found that circ102049 was highly expressed in primary CRC tumors with liver metastasis and closely correlated with the prognosis of patients with CRC. Circ102049 significantly enhanced the adhesion, migration and invasion abilities of CRC cells, and promoted CRC progression via a micro (mi)R-761/miR-192-3p-FRAS1-dependent mechanism. We found that circ102049 was highly expressed in primary CRC tumors with liver metastasis and closely correlated with the prognosis of patients with CRC. Yes Circ102049 significantly enhanced the adhesion, migration and invasion abilities of CRC cells, and promoted CRC progression via a micro (mi)R-761/miR-192-3p-FRAS1-dependent mechanism. 33131207 TARID LncRNA Homo sapiens Coronary Artery Disease Chinese Han population Mutation(rs2327433) Cell Proliferation Assay//Cell Cycle Assay//Genotyping//qRT-PCR SNP rs2327433 in lncRNA TARID was associated with CAD risk and the severity of CAD in the Chinese Han population. Yes We found that TARID silencing regulated cell proliferation and altered cell cycle progression by induced upregulation of CDK1 and PCNA. 35304681 TALNEC2 LncRNA Mus musculus Cerebral Ischemia/Reperfusion Injury mice brains Interaction( miR-650/ TALNEC2/APAF1) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay In this study, we measured the up-regulation of TALNEC2 and down-regulation of miR-650 in mice brains after cerebral ischemia/reperfusion (I/R) operation and in cultured neuroblastoma cells of neuro-2A (N2a) treated with oxygen glucose deprivation/reoxygenation (OGD/R). Then we verified the common predicted binding sites of miR-650 in TALNEC2 and 3'-UTR of apoptotic peptidase activating factor 1 (APAF1), a critical regulator in ischemic neuronal death, with bioinformatics. It was found that TALNEC2 played a critical role as a ceRNA for miR-650 and bound directly to miR-650 to mediate the APAF1. Yes Overexpression of miR-650 reduced N2a cell apoptosis induced by OGD/R. Furthermore, TALNEC2 knockdown reversed brain injury and neurological deficits induced by I/R in vivo. 33075457 hsa_circ_0024093 CircRNA Homo sapiens Arteriosclerosis Obliterans VSMCs Interaction(miR-4677-3p/miR-889-3p/USP9X/YAP1 axis ) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Tunel//CCK8//qRT-PCR//Flow Cytometry//RIP//FISH//Luciferase Report Assay//IP//EdU Staining//Transwell Assay Herein, hsa_circ_0024093, a circular RNA (circRNA) from YAP1, was identified to positively regulate the protein level of YAP1 in VSMCs. Mechanistically, it was found that hsa_circ_0024093 could regulate the expression of USP9X, which further induced YAP1 deubiquitination to stabilize YAP1 protein. In depth, it was revealed from mechanism experiments that hsa_circ_0024093 sequestered miR-889-3p or miR-4677-3p to enhance USP9X expression. Further, rescue assays validated that hsa_circ_0024093 regulated the miR-4677-3p/miR-889-3p/USP9X axis to accelerate the proliferation and migration of VSMCs in the in vitro model of ASO of the lower extremities. Yes Functionally, silencing of hsa_circ_0024093 obviously impeded cell proliferation and migration and promoted apoptosis in VSMCs in the in vitro model of ASO of the lower extremities. 34631281 circCHFR CircRNA Homo sapiens Coronary Disease HUVECs Interaction(miR-15b-5p/GADD45G axis) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//ELISA circCHFR expression was upregulated in patients with atherosclerosis and oxidized low-density lipoprotein (ox-LDL)-exposed HUVECs, whereas miR-15b-5p expression was downregulated. Further, we discovered that circCHFR serves as a molecular sponge of miR-15b-5p. GADD45G was found to be an important target of miR-15b-5p; miR-15b-5p mimic inhibited GADD45G expression, reduced apoptosis and proinflammatory cytokine secretion, and improved cell survival. Yes circCHFR silencing significantly improved viability and reduced apoptosis of HUVECs. In addition, the pro-apoptotic protein Bax and atherosclerosis-associated cytokines (interleukin-1β, interleukin-6, and tumor necrosis factor-α) were significantly downregulated, whereas the anti-apoptotic protein Bcl-2 was upregulated. 35137664 hsa_circ_0004951 CircRNA Homo sapiens Diabetic Nephropathies DKD patients and HK2 Interaction(miR-93-5p/NLRP3) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//ELISA//Bioinformatics Analysis Circ_0004951 was significantly upregulated in kidney tissues from DKD patients and HK2 in high glucose condition vs. control. Knockdown of circ_0004951 mediated a significant suppression of HK2 pyroptosis, while results from bioinformatics analysis revealed that circ_0004951 has binding sites with miR-93-5p and miR-93-5p could bind to NLRP3. Finally, observations from rescue experiments showed that down-regulation of miR-93-5p and upregulation of NLRP3 markedly attenuated the anti-pyroptosis and anti-inflammatory effects of circ_0004951 knockdown on HK2. Yes Knockdown of circ_0004951 mediated a significant suppression of HK2 pyroptosis, while results from bioinformatics analysis revealed that circ_0004951 has binding sites with miR-93-5p and miR-93-5p could bind to NLRP3. 35733856 circDLGAP4 CircRNA Homo sapiens Diabetic Nephropathies blood regulation[miR-143/ERBB3/NF-κB/MMP-2] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//EdU Staining//IF In our study, we found exosomal circ_DLGAP4 was increased in the exosomes isolated from HG-treated mesangial cells (MCs), DKD patients, and DKD rat models compared with the corresponding normal subjects. Subsequently, in vivo assays were performed and it was proved that overexpression of circ_DLGAP4 markedly promoted DKD progression in vivo via modulating miR-143/ERBB3/NF-κB/MMP-2. Yes Then, we observed that exo-circ_DLGAP4 significantly promoted proliferation and fibrosis of MCs cells. 33230102 circCDYL CircRNA Homo sapiens Wilms Tumor WT tissue compared with adjacent non-tumor tissue Interaction(miR-145-5p) In Vivo Experiment//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//EdU Staining//Transwell Assay We showed that circCDYL was downregulated in WT tissue compared with adjacent non-tumor tissue. Yes Upregulation of circCDYL could reduce cell proliferation, migration, and invasion. Mechanically, circCDYL, functioning as a miRNA sponge, decreased the expression level of miR-145-5p and TJP1 3'UTR was validated as the target of miR-145-5p, facilitating the circCDYL/miR-145-5p/TJP1 axis. 34485273 TAF4B CircRNA Homo sapiens Urinary Bladder Neoplasms Bca tissues Interaction(miR-1298-5p/TGFA axis) qRT-PCR//Western Blot In this study, we identified a novel circular RNA, circTAF4B, that is significantly upregulated in BCa and correlated with poor prognosis. Mechanistically, we found that circTAF4B facilitated the expression of transforming growth factor A (TGFA) by sponging miR-1298-5p. In this study, we identified a novel circular RNA, circTAF4B, that is significantly upregulated in BCa and correlated with poor prognosis. Yes Downregulated circTAF4B abolished the growth, metastasis and EMT process in BCa cells.Finally, circTAF4B enhanced the proliferation and EMT process of BCa cells in vivo. 34322376 TADA2A CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell lines and tissues Interaction(miR‑638/KIAA0101) RNA Pull-Down//Western Blot//ISH//Transfection//qPCR//FISH//RIP//PCR//IP//IHC//IF The results revealed that circTADA2A was upregulated in NSCLC, and that knockdown of circTADA2A inhibited cell proliferation and migration in the NSCLC cell lines A549 and H1299. Functional assays demonstrated that circTADA2A promoted proliferation and migration via interacting with microRNA (miR)‑638. Lastly, it was verified that circTADA2A promoted cell proliferation and migration, at least partially, via miR‑638/KIAA0101 signaling in A549 and H1299 cells. Yes The results revealed that circTADA2A was upregulated in NSCLC, and that knockdown of circTADA2A inhibited cell proliferation and migration in the NSCLC cell lines A549 and H1299. 34296306 TACR3-AS1 LncRNA Homo sapiens laryngeal squamous cell carcinoma LSCC cells Regulation Western Blot//Transfection//Wound Healing Assay//qRT-PCR//EdU Staining//Transwell Assay These results suggested that RP11-297P16.3 may inhibit the migration and invasion of LSCC cells by regulating the epithelial-mesenchymal transition process, suggesting that RP11-297P16.3 is a potential new target for treating LSCC. Yes Moreover, knockdown of RP11-297P16.3 significantly inhibited the migration and invasion of LSCC cells but had no effect on cell proliferation. The protein expression of N-cadherin and vimentin was notably decreased after RP11-297P16.3 knockdown; whereas, the protein expression of cadherin was significantly increased 33893613 circMKLN1 CircRNA Homo sapiens Capsule Opacification PCO lens samples and cells Interaction(miR-377-3p/CTGF Axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Circ-MKLN1 expression was enhanced in 17 PCO lens samples relative to 19 normal lens samples and TGF-β2-treated SRA01/04 cells contrasted to control cells. Circ-MKLN1 targeted miR-377-3p and the regulation of si-circ-MKLN1 for the TGF-β2-induced influences was related to the upregulation of miR-377-3p. CTGF was the target gene for miR-377-3p. CTGF knockdown also abolished the TGF-β2-mediated cell growth, migration and invasion of SRA01/04 cells. Yes Downregulation of circ-MKLN1 inhibited the effects of TGF-β2 on SRA01/04 cells. 34961410 circSPIDR CircRNA Homo sapiens cervical adenocarcinoma cervical adenocarcinoma tissues. Interaction(miR-431-5p regulating SORCS1 and CUBN ) In Vivo Experiment//Northern Blot//Western Blot//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Cell Apoptosis Assay//BrdU//Colony Formation Assay We found that circSPIDR was dramatically downregulated in cervical adenocarcinoma tissues. CircSPIDR was found to sponge miR-431-5p, thereby de-repressing sortin-related VPS10 domain-containing receptor 1 (SORCS1) and cubilin (CUBN) and inhibiting the development of cervical adenocarcinoma. In clinical cervical samples, circSPIDR expression correlated negatively with miR-431-5p expression and positively with SORCS1 and CUBN expression. Yes In cervical adenocarcinoma cells, overexpression of circSPIDR reduced cell viability, inhibited colony formation and promoted apoptosis, whereas knockdown of circSPIDR exerted the opposite effects. CircSPIDR overexpression also suppressed the tumorigenicity of cervical adenocarcinoma cells in a xenograft mouse model. 34326275 circEYA1 CircRNA Homo sapiens cervical adenocarcinoma cervical tissue regulation[circEYA1/miR-582-3p/CXCL14] qRT-PCR//RNA-seq Among them, circEYA1 was the most significantly downregulated circRNA in cervical adenocarcinoma.. In addition, the expression, correlation, and clinical diagnostic value of circEYA1/miR-582-3p/CXCL14 were confirmed in 198 clinical cervical tissue samples. Yes In cervical adenocarcinoma cells, circEYA1 overexpression led to suppression of cell viability and colony formation, promotion of apoptosis, and a decrease of the xenograft tumor growth. 33312754 circACAP2 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC Tissues regulation[miR-21-5p/STAT3 Signaling Axis] Western Blot//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay We demonstrate that CircRNA_ACAP2 functions as a tumor suppressor gene in HNSCC and that its function is regulated via the miR-21-5p/STAT3 signaling axis. Yes Overexpression of CircRNA_ACAP2 inhibits the proliferation and migration of HNSCC cells, while downregulation of CircRNA_ACAP2 has the opposite effect. 33363013 hsa_circ_0006571 CircRNA Homo sapiens Spinal Metastasis SM tissues regulation[miR-138/Sirt1 pathway] CCK8//RNA Pull-Down//qPCR//RIP Hsa_circ_0006571 was observed to be significantly upregulated in SM tissues through circRNA microarray and qPCR.Hsa_circ_0006571 promoted tumor cell migration and invasion via the miR-138/Sirt1 pathway. Yes Hsa_circ_0006571 silencing suppressed lung cancer cell proliferation and migration while promoting apoptosis. Hsa_circ_0006571 interacted with miR-138 to promote expression of Sirt1, leading to activation of epithelial-mesenchymal transition (EMT). 33489803 circANKMY2 CircRNA Homo sapiens Epilepsy, Temporal Lobe TLE tissues regulation[ miR-106b-5p/FOXP1 Axis] Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay We observed that circ_ANKMY2 and FOXP1 expression were reduced while miR-106b-5p expression was increased in TLE tissues. In sum, circ_ANKMY2 modulated TLE advancement via regulation of FOXP1 expression through sponging miR-106b-5p, and circ_ANKMY2 might be an underlying target for the improvement of TLE. Yes Overexpression of circ_ANKMY2 decreased spontaneous recurrent seizures (SRSs) in rat TLE model and blocked cell colony formation, proliferation, and induced cell apoptosis in SK-N-AS cells. 33095438 TATDN1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues regulation[Regulating miR-26b Methylation] Cell Proliferation Assay//qRT-PCR We found that TATDN1 was upregulated and miR-26b was downregulated in TNBC.Therefore, overexpression of TATDN1 promotes cancer cell proliferation in TNBC by regulating the methylation of miR-26b gene. Yes Cell proliferation analysis showed that TATDN1 positively regulated the proliferation of TNBC cells. 33192097 hsa_circ_0023984 CircRNA Homo sapiens Esophageal Neoplasms ESCC tumor tissues and cell lines Interaction(miR-1294/PI3K/Akt/c-Myc Pathway) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Transwell Assay circ_0023984 was remarkably upmodulated in ESCC tumor tissues and cell lines. circ_0023984 was the molecular sponge of miR-1294. miR-1294 could significantly inhibit ESCC cell proliferation, migration, invasion, and induce cell cycle arrest at G0/G1 phase. circ_0023984 affected ESCC progression through regulating miR-1294 expression. The target genes of miR-1294 were associated with cell cycle arrest and PI3K-Akt signaling pathway. circ_0023984 upregulated the expression of p-Akt and c-Myc by repressing miR-1294. circ_0023984 facilitates the malignant biological behaviors of ESCC cells through inhibiting miR-1294 and activating PI3K/Akt/c-myc pathway. circ_0023984 overexpression was correlated with advanced clinical stage and lymph node metastasis of ESCC patients. Yes circ_0023984 overexpression remarkably enhanced ESCC cell proliferation, migration, invasion, and cell cycle progression, while knockdown of circ_0023984 showed the opposite effect. 35522362 TCFL5 CircRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues Interaction(miR-543-FMNL2 Axis) qRT-PCR//Tunel 156 upregulated circRNAs and 91 downregulated circRNAs in esophageal cancer tissues were identified, and the expression of circRNA TCFL5 showed the most significant upregulation. Overexpression of circRNA TCFL5 promotes proliferation, invasion, and migration of Eca109 and KYSE150 and promotes tumor growth in vivo. circRNA TCFL5 served as a sponge of miR-543, and FMNL2 was a downstream target gene of miR-543. circRNA TCFL5 promotes cell proliferation, migration, and invasion of Eca109 and KYSE150 by modulating the miR-543/FMNL2 axis. Macrophage M2 polarization promoted proliferation, invasion, and migration of Eca109 and KYSE150 cells, and circRNA TCFL5 mediated macrophage M2 polarization by regulating the FMNL2/miR-543 axis. Yes Overexpression of circRNA TCFL5 promotes proliferation, invasion, and migration of Eca109 and KYSE150 and promotes tumor growth in vivo. 35646112 hsa_circ_0090364 CircRNA Homo sapiens Graves Disease Graves' disease patients Expression(highly expressed) Transfection//Flow Cytometry//qRT-PCR//Microarray//Cell Proliferation Assay The level of hsa_circ_0090364 was elevated in Graves' disease patients and positively correlated with thyroid-stimulating hormone receptor antibodies. Further analyses suggested that hsa_circ_0090364 may regulate the JAK-STAT pathway via the hsa-miR-378a-3p/IL-6ST/IL21R axis to promote cell growth. Yes The level of hsa_circ_0090364 was elevated in Graves' disease patients and positively correlated with thyroid-stimulating hormone receptor antibodies. Further analyses suggested that hsa_circ_0090364 may regulate the JAK-STAT pathway via the hsa-miR-378a-3p/IL-6ST/IL21R axis to promote cell growth. 36018563 TCONS_00006195 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[ENO1] RNA Pull-Down//Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RIP//IHC In this study, we identified an lncRNA, lncRNA-TCONS_00006195 (termed lncRNA-6195), which was downregulated in HBV-related HCC tissues compared with its expression in adjacent noncancerous hepatic tissues. Clinical data showed that a low level of lncRNA-6195 was correlated with a high Edmondson-Steiner grade of the tumor and a poor prognosis in HCC patients. Yes Furthermore, lncRNA-6195 acted as a tumor repressor in the development of hepatitis B-related HCC, inhibiting HCC cell proliferation in vitro and in vivo. 30518748 TCONS_00004099 LncRNA Homo sapiens Glioma glioma tissues and glioma cell lines Regulation(PTPRF) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qPCR//CCK8//Colony Formation Assay//Transwell Assay LncRNA TCONS_00004099 was significantly increased in glioma tissues and glioma cell lines. The miRNA mimics or inhibitor of miRNA TCONS_00004099 was used to reverse the effects of knockdown or overexpression of lncRNA TCONS_00004099, respectively. Western Blot analyses verified that PTPRF is one of the downstream targets of lncRNA TCONS_00004099. Yes Knockdown of this lncRNA suppressed cell proliferation, migration, invasion and enhanced TMZ-induced apoptosis in U87 and U251 cell lines in vitro and in vivo. 34277823 hsa_circ_0056686 CircRNA Homo sapiens uterine fibroid ULM tissues and cell line Interaction(miR-515-5p) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay Hsa_circ_0056686 level was higher in CAFs than NFs, and also higher in ULM tissues than in adjacent tissues. Luciferase gene reporter and RNA pull-down assays indicated that miR-515-5p directly bound with hsa_circ_0056686. MiR-515-5p overexpression restored the hsa_circ_0056686-shRNA-mediated malignant biological behaviors of ULM cells. Hsa_circ_0056686 contributed to tumor-promoting effects of CAFs in ULM, manifested by promoting ULM cell proliferation and migration and reducing ERS-induced apoptosis through sponging miR-515-5p. Yes CAFs-CM significantly increased the proliferation and migration and inhibited apoptosis of ULM cells, as confirmed by CCK-8, transwell, and flow cytometry assays. Moreover, conditioned medium (CM) from CAFs transfected with hsa_circ_0056686 shRNA (CAFssh-circ_0056686-CM) abolished CAFs-mediated proliferation, migration and apoptosis of ULM cells. Meanwhile, knockdown of hsa_circ_0056686 reversed the inhibitory effects of CAFs-CM on brefeldin A-induced cell apoptosis. 35390056 TCLlnc1 LncRNA Homo sapiens Lymphoma, T-Cell, Peripheral main subtypes of PTCL Interaction(HNRNPD/YBX1 complex ) In Vivo Experiment//Western Blot//Co-IP//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//Transwell Assay In this research, a novel lncRNA (ENST00000503502) was identified overexpressed in the main subtypes of PTCL, and designated as T cell lymphoma-associated lncRNA1 (TCLlnc1). As the mechanism of action, TCLlnc1 directly interacted with transcription activator heterogeneous nuclear ribonucleoprotein D (HNRNPD) and Y-box binding protein-1 (YBX1) by acting as a modular scaffold. Serum TCLlnc1 was associated with extranodal involvement, high-risk International Prognostic Index, and poor prognosis of the patients. Yes Both in vitro and in vivo, overexpression of TCLlnc1 promoted T-lymphoma cell proliferation and migration, both of which were counteracted by the knockdown of TCLlnc1 using small interfering RNAs. 33767152 TCL6 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues, cell lines regulation[PI3K/AKT signaling pathway] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay Bioinformatics analyses indicated TCL6 was evidently downregulated in HCC tissues compared with normal controls. TCL6 was downregulated while microRNA-106a-5p (miR-106a-5p) was upregulated in HCC cell lines.Collectively, these results revealed TCL6 as a tumor-suppressive lncRNA regulates PI3K/AKT signaling pathway via directly binding to miR-106a-5p in HCC. Yes Functionally, TCL6 inhibited the proliferative, migratory, and invasive potentials of HCC cells as analyzed by cell counting kit-8, scratch wound healing, and transwell assays, respectively. 32020591 TCL6 LncRNA Homo sapiens Retinoblastoma Rb tissues and cell lines Regulation[PTEN/PI3K/AKT signaling pathway] Immunoblotting//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//ELISA//EdU Staining In the present study, we found the expression of lncRNA T-cell leukemia/lymphoma 6 (TCL6) was significantly downregulated in Rb tissues and cell lines.Moreover, lncRNA TCL6 serves as a sponge for miR-21, a previously-reported oncogenic miRNA in Rb, by direct targeting to negatively regulated miR-21 expression, therefore modulating Rb proliferation through miR-21. TCL6 overexpression inhibited Rb cell proliferation while miR-21 overexpression exerted an opposing effect; the effect of TCL6 overexpression was partially attenuated by miR-21 overexpression. PTEN/PI3K/AKT signaling pathway was involved in lncRNA TCL6/miR-21 axis modulating Rb cell proliferation. Taken together, lncRNA TCL6 serves as a tumor suppressor by acting as a sponge for miR-21 to counteract miR-21-mediated PTEN repression. Yes Knockdown of lncRNA TCL6 promoted cell proliferation while reduced cell apoptosis in Rb cells. 31680766 TCL6 LncRNA Homo sapiens Kidney Neoplasms ccRCC tissues Interaction(miR155-Src/Akt/EMT network) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Invasion Assay//IF Expression analyses revealed that lncTCL6 is downregulated in ccRCC compared with normal tissues. In conclusion, this study is the first report documenting the lncTCL6-miR155-Src/Akt/EMT network as a novel regulatory mechanism in aggressive ccRCC and a promising therapeutic target to inhibit renal cancer. Yes Overexpression of lncTCL6 in ccRCC cell lines impaired their oncogenic functions, such as cell proliferation and migration/invasion, and induced cell-cycle arrest and apoptosis; conversely, depletion of lncTCL6 rescued these phenotypic effects. 33500248 TCF7 LncRNA Homo sapiens Ovarian Neoplasms tumor and adjacent tissues from 76 EOC patients, SKOV3 and OVCAR3 cells Regulation(ITGB8) Western Blot//Migration Assay//CCK8//qRT-PCR//Invasion Assay Lnc-TCF7 was upregulated in EOC cell lines; its overexpression increased cell proliferation, migration, invasion, but decreased apoptosis and promoted CD44, CD133 expressions, CD44+CD133+ cell proportion, spheres formation efficiency and drug resistance to cisplatin in SKOV3 and OVCAR3 cells. Yes Lnc-TCF7 was upregulated in EOC cell lines; its overexpression increased cell proliferation, migration, invasion, but decreased apoptosis and promoted CD44, CD133 expressions, CD44+CD133+ cell proportion, spheres formation efficiency and drug resistance to cisplatin in SKOV3 and OVCAR3 cells. Besides, lnc-TCF7 ShRNA exhibited opposite effects comparing with its overexpression. Microarray analysis revealed 267 mRNAs were modulated by lnc-TCF7 dysregulation, among which ITGB8 was the most dysregulated one, which was validated by subsequent western blot and RT-qPCR. 34868900 TATDN1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction[targeting miRNA-6089] qRT-PCR//Luciferase Report Assay TATDN1 was upregulated in HCC tissues and cell lines. Subsequently, LIX1L was verified to be the target of miRNA-6089. The overexpression of LIX1L partially reversed the regulatory effect of miRNA-6089 on the proliferative rate and cell cycle progression of HCC. Yes The overexpression of TATDN1 accelerated the proliferative rate and cell cycle progression of HCC. 31378885 TCF7 LncRNA Homo sapiens Multiple Myeloma patients with MM Interaction( miR-200c ) CCK8//qRT-PCR//Transfection The results demonstrated that lncRNA TCF7 expression was upregulated in patients with MM compared with controls, and the receiver operating characteristic curve revealed that lncRNA TCF7 could distinguish patients with MM from controls with an area under the curve of 0.793 (95% CI, 0.725-0.861). lncRNA TCF7 also promoted cell proliferation, whereas it reduced cell apoptosis and miR-200c expression in RPMI-8226 and U-266 cells. In conclusion, the present results suggested that lncRNA TCF7 may be used as a potential biomarker and as a treatment target for MM. The results demonstrated that lncRNA TCF7 expression was upregulated in patients with MM compared with controls, and the receiver operating characteristic curve revealed that lncRNA TCF7 could distinguish patients with MM from controls with an area under the curve of 0.793 (95% CI, 0.725-0.861). In patients with MM, high lncRNA TCF7 expression was associated with higher β2-microglobulin, more advanced International Staging System stage and increased t (14; 16) mutations. Yes lncRNA TCF7 also promoted cell proliferation, whereas it reduced cell apoptosis and miR-200c expression in RPMI-8226 and U-266 cells. In conclusion, the present results suggested that lncRNA TCF7 may be used as a potential biomarker and as a treatment target for MM. 33552250 TCEAL1 LncRNA Homo sapiens Liver Neoplasms cell line(HepG2 ) Expression[lower expressed] CCK8//qRT-PCR//Transwell Assay Compared with that in the control group, the mRNA expression level of lincRNA-p21 in cells in the experimental group was obviously decreased (p<0.05). Yes When lincRNA-p21 was inhibited, the proliferation, invasion and migration ability of HepG2 cells were significantly enhanced, and the apoptosis rate was significantly decreased. 31186722 TBX5-AS1:2 LncRNA Homo sapiens Tetralogy of Fallot cardiac tissues regulation[ reducing TBX5 expression] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay Using Gene Expression Omnibus data mining, bioinformatics analysis and clinical heart tissue sample detecting, we identified a novel antisense lncRNA TBX5-AS1:2 with unknown function that was significantly down-regulated in injured cardiac tissues from TOF patients.In conclusion, these results indicated that lncRNA TBX5-AS1:2 may be involved in TOF by affecting cell proliferation by targeting TBX5. Yes Moreover, lncRNA TBX5-AS1:2 knock-down inhibited the proliferation of HEK293T cells. 32368852 TBX5-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues, plasma, and cells regulation[PI3K/AKT Pathway ] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay TBX5-AS1 expression was down-regulated in NSCLC tissues, plasma, and cells, and associated with lymph node metastasis and histological grade. We innovatively proposed a possible model of TBX5-AS1-mediated gene regulation in NSCLC progression that TBX5-AS1 inhibited the aggressive phenotypes of NSCLC cells through inactivating the PI3K/AKT pathway. This finding provided a novel insight into NSCLC pathogenesis. TBX5-AS1 expression was down-regulated in NSCLC tissues, plasma, and cells, and associated with lymph node metastasis and histological grade. Yes Overexpression of TBX5-AS1 inhibited cell viability, colony formation, migration, and invasion, while it promoted apoptosis. Conversely, knockdown of TBX5-AS1 showed the completely opposite results. 32884287 TBULC LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumors and adjacent normal tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//ChIP//Transwell Assay Stimulation with TGFβ in NSCLC cell lines significantly Expression[Expression[up-expression]-expression]regulated the expression level of the nuclear-localized lncRNA TBULC. The RACE assay indicated that the full-length TBULC sequence was 1,020 nucleotides, and the sequence was located on chromosome 15. Cell function experiments showed that the TBULC played a crucial role in promoting NSCLC metastasis.The expression level of TBULC in 106 NSCLC tumor tissues was significantly higher than that in adjacent normal tissues, and TBULC was proven to be an independent prognostic factor in NSCLC patients [p = 0.030, OR = 0.513 (0.281-0.936)]. Yes KnockExpression[down-expression] of TBULC significantly sExpression[Expression[up-expression]-expression]pressed the invasion and migration of NSCLC cells, and overexpression of TBULC had the opposite effects. 31921623 circPRKDC CircRNA Homo sapiens T-cell acute lymphoblastic leukemia T-ALL cells Interaction(microRNA-653-5p/Reelin mediation of the PI3K/AKT/mTOR signaling pathway) Western Blot//Transfection//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay The expression levels of Circ-PRKDC and RELN were upregulated in T-ALL tissues and cells while the levels of miR-653-5p were downregulated. Thereafter, then silencing of Circ-PRKDC, or the enforced expression of miR-653-5p, repressed the expression of RELN and the activation of the PI3K/AKT/mTOR signaling pathway, thus enhancing cell autophagy and apoptosis, and disrupting cell proliferation. Circ-PRKDC acted a sponge for miR-653-5p while miR-653-5p targeted RELN. The knockdown of miR-653-5p abrogated the silencing of Circ-PRKDC-induced effects in T-ALL cells. The depletion of Circ-PRKDC elevated miR-653-5p to silence RELN-mediated PI3K/AKT/mTOR signaling activation, thereby enhancing autophagy and apoptosis in T-ALL cells. Yes Thereafter, then silencing of Circ-PRKDC, or the enforced expression of miR-653-5p, repressed the expression of RELN and the activation of the PI3K/AKT/mTOR signaling pathway, thus enhancing cell autophagy and apoptosis, and disrupting cell proliferation. 33615686 TATDN1 LncRNA Homo sapiens Breast Neoplasms BCa tissues,cell lines Interaction[microRNA-140-3p] CCK8//qRT-PCR//Luciferase Report Assay TATDN1 was highly expressed in BCa tissues and cell lines.Dual-luciferase reporter gene assay indicated that TATDN1 could bind to microRNA-140-3p, which was lowly expressed in BCa. Moreover, microRNA-140-3p partially inhibited the role of TATDN1 in regulating cellular behaviors of BCa cells. NOVA1 was predicted to be the target gene of microRNA-140-3p. Overexpression of NOVA1 partially abolished the inhibitory effects of microRNA-140-3p on proliferation and cell cycle progression of MCF-7 and MDA-MB-231 cells. Yes Upregulation of TATDN1 promoted the proliferative potential and cell cycle progression of MCF-7 and MDA-MB-231 cells. 31298381 circSLC7A6 CircRNA Homo sapiens Wilms Tumor WT tissues and cells Interaction(microRNA-107/ ABL proto-oncogene 2 axis) In Vivo Experiment//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//IHC//Transwell Assay In our study, we found that circSLC7A6 was upregulated in cancerous WT tissues and cells.miR-107 was identified as a direct target of circSLC7A6, and circSLC7A6 could negatively regulate miR-107 expression. In addition, circSLC7A6 knockdown inhibited WT progression, while the effect was partially abolished by the downregulation of miR-107. Additionally, ABL proto-oncogene 2 axis (ABL2) was verified as a downstream gene of miR-107, and circSLC7A6 could upregulate ABL2 expression by serving as a ceRNA of miR-107. Yes Cell apoptosis was increased while cell viability, migration, and invasion were repressed by circSLC7A6 silencing. Besides, circSLC7A6 knockdown suppressed WT tumor growth in vivo. Moreover, functional assays revealed that ABL2 overexpression reversed the impact of circSLC7A6 depletion on cell proliferation, migration, invasion, and apoptosis of WT. 34787058 TGLC15 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[stabilizing Sox4] qRT-PCR//RIP TGLC15 is significantly overexpressed in tumor tissues and HCC cell lines. Mechanistic studies showed that TGLC15 interacted with Sox4 and interaction between TGLC15 and Sox4 could stabilize Sox4 via reduction in proteasome-mediated degradation. Higher TGLC15 levels correlated with advanced malignant characteristics such as TNM stages, tumor size, and metastasis. Yes TGLC15 advanced HCC migration and viability. The in vivo experiments supported that xenograft tumor growth and proliferation were facilitated by TGLC15 overexpression. 31495979 THAP9-AS1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues Regulation[THAP9-AS1/YAP axis ] RIP//qRT-PCR We demonstrated that lncRNA THAP9-AS1 is overexpressed in PDAC in multiple patient sample sets, which is significantly associated with poor outcome of patients with PDAC. Our findings indicate that THAP9-AS1 plays an important role in PDAC growth via enhancing YAP signaling, which in turn also modulates THAP9-AS1 transcription. THAP9-AS1/YAP axis may serve as a potential biomarker and therapeutic target for PDAC treatment. Yes THAP9-AS1 promotes PDAC cells growth both in vitro and in vivo. 31831555 THAP9-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue and cells Expression(highly expressed) qRT-PCR The expression of THAP9-AS1 were markedly upregulated in HCC tissue and cells. Overexpression of THAP9-AS1 promoted HCC cell proliferation, silencing THAP9-AS1 inhibited HCC cell proliferation. THAP9-AS1 expression was correlated with tumor size, tumor node metastasis (TNM) stage. High THAP9-AS1 expression was associated with poor prognostic survival in HCC patients. Yes Overexpression of THAP9-AS1 promoted HCC cell proliferation, silencing THAP9-AS1 inhibited HCC cell proliferation. 36170961 TMEM161B-DT LncRNA Homo sapiens Glioma U87 cells and U251 cells Interaction(miR-27a-3p-FANCD2/CD44 signal axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay These results demonstrated that the lncRNA TMEM161B-AS1-hsa-miR-27a-3p-FANCD2/CD44 signal axis regulated the malignant biological behavior of GBM and TMZ resistance. These findings were expected to provide promising therapeutic targets for the treatment of glioma. Yes Knockdown of TMEM161B-AS1 down-regulated the expression of FANCD2 and CD44 by sponging hsa-miR-27a-3p, inhibited the proliferation, migration, invasion and promoted apoptosis, ferroptosis of U87 cells and U251 cells. Down-regulation of lncRNA TMEM161B-AS1 and/or over-expression of hsa-miR-27a-3p down-regulated the expression of FANCD2 and CD44, and inhibited the tumor growth in nude mice. 34689169 TMEM44-AS1 LncRNA Homo sapiens Glioma glioma tissues Interaction(SerpinB3/Myc/EGR1/IL-6 signaling) RNA Pull-Down//Western Blot//Co-IP//FISH//qRT-PCR//IF//Luciferase Report Assay//RNA-seq//ChIP-seq//ChIP We identified a novel lncRNA TMEM44-AS1, which was aberrantly expressed in glioma tissues, and that increased TMEM44-AS1 expression was correlated with malignant progression and poor survival for patients with glioma. Mechanistically, TMEM44-AS1 is directly bound to the SerpinB3, and sequentially activated Myc and EGR1/IL-6 signaling; Myc transcriptionally induced TMEM44-AS1 and directly bound to the promoter and super-enhancer of TMEM44-AS1, thus forming a positive feedback loop with TMEM44-AS. We identified a novel lncRNA TMEM44-AS1, which was aberrantly expressed in glioma tissues, and that increased TMEM44-AS1 expression was correlated with malignant progression and poor survival for patients with glioma. Yes Expression of TMEM44-AS1 increased the proliferation, colony formation, migration, and invasion of glioma cells. Knockdown of TMEM44-AS1 in glioma cells reduced cell proliferation, colony formation, migration and invasion, and tumor growth in a nude mouse xenograft model. 34696771 TMEM238L LncRNA Homo sapiens Carcinoma, Hepatocellular regulation[miR-942-5p and GFI1] Western Blot//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay In summary, LINC00675 might act as a prognostic marker for HCC, which can inhibit HCC development via regulating miR-942-5p and GFI1. Yes Up-regulation of LINC00675 obviously repressed the migration and invasion capacity of SMCC-7721 and QGY-7703 cells in vitro. 33489916 TMEM238L LncRNA Homo sapiens Urinary Bladder Neoplasms MIBC tissues Expression[lower expressed] qRT-PCR//Western Blot//Transwell Assay We found that LINC00675 expression was decreased in MIBC tissues compared to matched normal tissues, and was correlated with lymph node-metastatic MIBC. MIBC patients with low expression of LINC00675 had worse survival rates than those with high expression. Yes Functional investigation showed that ectopic expression of LINC00675 inhibited bladder cancer cell migration, invasion and proliferation, whereas LINC00675 knockdown presented an opposite effect. 32367602 TMEM238L LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Regulation[Wnt/β-catenin signaling ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay LINC00675 was upregulated in the cervical cancer tissues and cell lines, and upregulation of LINC00675 was positively correlated with advanced clinical stage and poor prognosis in patients with cervical cancer. In conclusion, our results implied that LINC00675 promoted cancer cell proliferation, migration, and invasion, and inhibit apoptosis likely by modulating the Wnt/β-catenin pathway. LINC00675 was upregulated in the cervical cancer tissues and cell lines, and upregulation of LINC00675 was positively correlated with advanced clinical stage and poor prognosis in patients with cervical cancer. Yes Overexpression of LINC00675 promoted cervical cancer cell proliferation, invasion, and migration. 30372871 TMEM238L LncRNA Homo sapiens Glioma glioma tissues and cell lines Expression[highly expressed] qRT-PCR//MTT//Cell Cycle Assay//Western Blot Thus, we reported LINC00675 was overexpressed in glioma tissues and cell lines, and positively associated with advanced WHO grade, large tumor size and poor prognosis. Thus, we reported LINC00675 was overexpressed in glioma tissues and cell lines, and positively associated with advanced WHO grade, large tumor size and poor prognosis. Moreover, univariate and multivariate analyses suggested that high-expression of LINC00675 was an independent unfavorable prognostic predictor for glioma. Yes The in vitro experiment showed that silencing of LINC00675 inhibits glioma cell proliferation, migration and invasion through regulating TRIP6. 30061182 TMEM238L LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cell lines regulation[Wnt/β-catenin pathway] qRT-PCR//Western Blot LINC00675 was downregulated in ccRCC tissues and cell lines.Overexpression of LINC00675 attenuates ccRCC to proliferate, migrate, and invade by activating the Wnt/β-catenin pathway. Yes Overexpression of LINC00675 attenuated proliferative, migratory, and invasive capacities of 786-O and 769-P cells. 32196582 TMEM220-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction(TMEM220/β-catenin axis) qRT-PCR TMEM220-AS1 downregulation was confirmed in HCC cell lines. Interestingly, ectopic expression of TMEM220-AS1 increased TMEM220 levels in HCC cells. Decreased TMEM220 levels were observed in HCC tissues and cell lines. Mechanistically, TMEM220 overexpression reduced the nuclear accumulation of β-catenin and decreased MYC, Cyclin D1, and Snail1 mRNA levels in HCCLM3 cells. BIO, a GSK3β inhibitor, eliminated TMEM220-induced Wnt/β-catenin pathway inactivation and inhibited HCC cell proliferation and mobility. In conclusion, TMEM220-AS1 and TMEM220 were expressed at low levels in HCC patients. TMEM220-AS1 expression was associated with tumor stage, venous infiltration, tumor size, and survival of HCC patients. Yes TMEM220-AS1 overexpression suppressed the migration, invasion, and proliferation of HCC cells. TMEM220 overexpression suppressed HCC cell proliferation and mobility. TMEM220 knockdown eliminated the suppressive effect of TMEM220-AS1 in HCCLM3 cells. 34659569 TMEM220-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction( miR-484/MAGI1) qRT-PCR The results showed that TMEM220-AS1 was expressed at considerably low levels in HCC.TMEM220-AS1, which was detected primarily in the cytoplasm, functioned as an miRNA sponge to bind miR-484 and promote the level of membrane-associated guanylate kinase, WW, and PDZ domain containing 1 (MAGI1), thereby curbing the malignant phenotypes of HCC cells. Yes It was demonstrated that malignant phenotypes and EMT of HCC cells were promoted by the knock down of TMEM220-AS1 both in vivo and in vitro. 34422806 TMEM161B‐AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction(miR‐23a‐3p/HIF1AN signal axis) cell invasion assay//Western Blot//Transfection//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay Here, TMEM161B‐AS1 and HIF1AN were significantly lower in ESCC tissues than in normal samples, and their low expressions were both related to TNM stage, lymph node metastasis and poor prognosis of ESCC patients.Mechanistically, TMEM161B‐AS1 manipulated HIF1AN expression by competitively sponging miR‐23a‐3p in ESCC cells. MiR‐23a‐3p mimic and HIF1AN siRNA partly reversed cell phenotypes mediated by TMEM161B‐AS1 in ESCC cells. Here, TMEM161B‐AS1 and HIF1AN were significantly lower in ESCC tissues than in normal samples, and their low expressions were both related to TNM stage, lymph node metastasis and poor prognosis of ESCC patients. Yes Functionally, TMEM161B‐AS1 overexpression or miR‐23a‐3p depletion suppressed the proliferation, invasion and glycolysis as well as reduced glucose consumption and lactate production in ESCC cells. 34046994 TMEM92-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(YBX1/CCL5) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Transwell Assay TMEM92-AS1 was significantly overexpressed in GC tissues and correlated with poor overall survival and disease-free survival. RNA transcriptome sequence analysis revealed a potential downstream target gene, C-C motif chemokine ligand 5 (CCL5), and a mechanistic study found that TMEM92-AS1 regulated CCL5 by binding to the transcription factor Y-box binding protein 1(YBX1), which has oncogene properties. TMEM92-AS1 was significantly overexpressed in GC tissues and correlated with poor overall survival and disease-free survival. Yes Furthermore, TMEM92-AS1 promoted GC cell proliferation and migration in vitro and tumorigenic ability in vivo. 33247987 TMEM147-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostatic carcinoma tissues and cells Interaction( TMEM147-AS1/miR-133b/ZNF587 axis) In Vivo Experiment//Western Blot//qRT-PCR//Cell Proliferation Assay//IHC//Invasion Assay TMEM147-AS1 and ZNF587 were up-regulated in prostatic carcinoma tissues and cells. miR-133b was directly targeted in both TMEM147-AS1 and ZNF587. Overexpression of miR-133b restrained prostate cancer cell viability, invasion and aerobic glycolysis. TMEM147-AS1 competitively targeted miR-133b, therefore counteracting miR-133b-mediated repression on ZNF587 Yes Knockdown of TMEM147-AS1 or ZNF587 within prostate cancer cells significantly restrained cell viability, invasion and aerobic glycolysis in vitro and suppressed the neoplasia of prostatic carcinoma in vivo. 36181243 TMCC1-DT LncRNA Homo sapiens Liver Neoplasms LC tissues and cell lines Expression(highly expressed) Western Blot//Transfection//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay TMCC1-AS1 expression was found to be significantly upregulated in LC tissues and cell lines compared with the corresponding controls. TMCC1-AS1 expression was associated with advanced TNM stage and lymph node metastasis.Furthermore, high TMCC1-AS1 expression predicted poor survival in patients with LC. Yes Knockdown of TMCC1-AS1 significantly inhibited the proliferation, migration and invasion of HepG2 and SNU-182 cells, while overexpression of TMCC1-AS1 had the opposite effect in HepG2 and SNU-182 cells. At the molecular level, downregulation of TMCC1-AS1 expression resulted in increased E-cadherin expression and decreased proliferating cell nuclear antigen, Ki67, N-cadherin and Vimentin expression in HepG2 cells. Overexpression of TMCC1-AS1 had the opposite effects on these factors in SNU-182 cells. 34589152 TMC6 LncRNA Homo sapiens Thyroid Neoplasms THCA tissues Interaction(miR-513c-5p/LPAR5 axis) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU//Invasion Assay//Transwell Assay TNRC6C-AS1 was highly expressed in THCA tissues, and knockout of TNRC6C-AS1 reduced the viability, proliferation, migration, and invasion of THCA cells. LPAR5 is the target gene for miR-513c-5p, which has the ability to eliminate the influence of miR-513c-5p on THCA cells. Yes TNRC6C-AS1 was highly expressed in THCA tissues, and knockout of TNRC6C-AS1 reduced the viability, proliferation, migration, and invasion of THCA cells. 34393509 TM4SF1-AS1 LncRNA Homo sapiens gastric adenocarcinoma CD8+ T cells Regulation Transfection//qRT-PCR//Survival Analysis//Luciferase Report Assay//RNA-seq//ChIP-seq We found that the expression of SE-associated lncRNA TM4SF1-AS1 was negatively correlated with the proportion of CD8+ T cells present in STAD. TM4SF1-AS1 suppresses T cell-mediated immune killing function and predicts immune response to anti-PD1 therapy. Yes TM4SF1-AS1 suppresses T cell-mediated immune killing function and predicts immune response to anti-PD1 therapy. 35311149 TM4SF19-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC cells Interaction(miR-153-3p/HNRNPC) CCK8//qRT-PCR RT-qPCR analysis was done to test TM4SF19-AS1 expression and identify the up-regulation of TM4SF19-AS1 in HNSCC cells. It turned out that TM4SF19-AS1 modulated laminin subunit gamma 1 (LAMC1) expression via sequestering microRNA-153-3p (miR-153-3p) and recruiting heterogeneous nuclear ribonucleoprotein C (HNRNPC) protein. Rescue assays confirmed that TM4SF19-AS1 contributed to HNSCC cell malignant behaviors via up-regulating LAMC1. Yes Loss-of-function assays were also involved, and the data implied that TM4SF19-AS1 knockdown hampered the proliferation, migration, invasion, along with epithelial-mesenchymal transition (EMT) of HNSCC cells. In vivo assays revealed TM4SF19-AS1 depletion restrained HNSCC tumor growth. 36411963 TM1-3P LncRNA Rattus norvegicus Osteoarthritis hFSCs, OA rats Interaction(miR-144-3p/ONECUT2 Axis) CCK8//EdU Staining//Luciferase Report Assay//Flow Cytometry Expressions of ONECUT2 and LncRNA TM1-3P were increased, and expression of miR-144-3p was decreased in interleukin (IL)-1β-induced human fibroblast synovial cells (hFSCs). LncRNA TM1-3P improved inflammation and damage of knee joints in OA rats through miR-144-3p/ONECUT2 axis, providing a new theoretical basis for gene therapy of OA. Yes Overexpression of LncRNA TM1-3P up-regulated the expression of ONECUT2, promoted cell proliferation, and inhibited apoptosis 36178080 TLX1NB LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues and cells Regulation(STAT5A) qRT-PCR//Wound Healing Assay//Transwell Assay//Western Blot Firstly, TLX1NB was up-regulated in colon cancer tissues and increased TLX1NB expression was significantly associated with advanced N stages.Moreover, the inhibition of STAT5A phosphorylation reversed TLX1NB overexpression-associated increase in HCT116 cell migratory and invasive activity. In conclusion, TLX1NB enhances STAT5A phosphorylation to promote colon cancer cell invasion, migration, and metastasis. Firstly, TLX1NB was up-regulated in colon cancer tissues and increased TLX1NB expression was significantly associated with advanced N stages. Yes . In wound healing assays and transwell assays, TLX1NB overexpression promoted HCT116 cell migration and invasion while TLX1NB knockdown inhibited SW620 cell migration and invasion. In vivo, TLX1NB knockdown suppressed pulmonary metastasis of SW620 cell and vimentin expression but increased E-cadherin expression. Then, TLX1NB overexpression enhanced signal transducer and activator of transcription 5A (STAT5A) phosphorylation and TLX1NB knockdown suppressed STAT5A phosphorylation. 35502613 TLR8-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-34a ) CCK8//qRT-PCR//RNA Pull-Down We found that TLR8-AS1 was upregulated in HCC and predicted poor survival. Across HCC tissues, TLR8-AS1 was inversely correlated with mature miR-34a, but not miR-34a precursor. In HCC cells, TLR8-AS1 overexpression downregulated mature miR-34a, but not miR-34a precursor. We found that TLR8-AS1 was upregulated in HCC and predicted poor survival. Yes Cell proliferation and Transwell migration assay showed that TLR8-AS1 overexpression reduced the enhancing effects of miR-34a on cell proliferation and migration. 34665305 TMEM87A CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-142-5p/ULK1 axis ] RNA Pull-Down//Western Blot//qRT-PCR//PCR//IF CircTMEM87A was dramatically elevated in GC tissues and cell lines. Our findings suggest that circTMEM87A functions as an oncogene through the miR-142-5p/ULK1 axis in GC. CircTMEM87A was dramatically elevated in GC tissues and cell lines, and high circTMEM87A expression was closely correlated with poor prognosis of GC patients. Yes Knockdown of circTMEM87A suppressed cell growth, migration, invasion and induced apoptosis in vitro, as well as inhibited GC tumorigenicity and lung metastasis potential in vivo. 33155080 TMPO LncRNA Homo sapiens Cholangiocarcinoma CHOL cells Interaction(let-7g-5p/ high-mobility group A1 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay Our results, through quantitative real-time PCR and Western blot detection, showed that TMPO-AS1 and HMGA1 were overexpressed while let-7 g-5p was underexpressed in CHOL. Cell function experiments in CHOL cells revealed that TMPO-AS1 knockdown inhibited cell proliferation, colony formation, and cell migration, but induced apoptosis. TMPO-AS1 knockdown also suppressed tumor growth in vivo. Together with luciferase assay and Western blotting, we found that TMPO-AS1 could sponge let-7 g-5p to promote HMGA1 expression. Moreover, HMGA1 overexpression attenuated the effect of TMPO-AS1 downregulation in CHOL cells. Overall, our findings identified the oncogenic effect of TMPO-AS1 on CHOL cells, which may put forward a novel methodology for CHOL diagnosis and therapy. Yes Cell function experiments in CHOL cells revealed that TMPO-AS1 knockdown inhibited cell proliferation, colony formation, and cell migration, but induced apoptosis. TMPO-AS1 knockdown also suppressed tumor growth in vivo. 35040749 THAP9-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(THAP9-AS1/miR-133b/SOX4) CCK8//qRT-PCR//Western Blot we found that THAP9-AS1 was overexpressed in ESCC tissues and cells. High THAP9-AS1 expression was positively correlated with tumor size, TNM stage, lymph node metastasis, and worse prognosis. Functionally, depletion of THAP9-AS1 suppressed cell proliferation, migration, and invasion, while enhanced apoptosis in vitro. Consistently, knockdown of THAP9-AS1 inhibited xenograft tumor growth in vivo. Mechanistically, THAP9-AS1 could serve as a competing endogenous RNA (ceRNA) for miR-133b, resulting in the upregulation of SOX4. Reciprocally, SOX4 bound to the promoter region of THAP9-AS1 to activate its transcription. Moreover, the anti-tumor property induced by THAP9-AS1 knockdown was significantly impaired due to miR-133b downregulation or SOX4 overexpression. In this study, we found that THAP9-AS1 was overexpressed in ESCC tissues and cells. High THAP9-AS1 expression was positively correlated with tumor size, TNM stage, lymph node metastasis, and worse prognosis. Yes Functionally, depletion of THAP9-AS1 suppressed cell proliferation, migration, and invasion, while enhanced apoptosis in vitro. Consistently, knockdown of THAP9-AS1 inhibited xenograft tumor growth in vivo. Mechanistically, THAP9-AS1 could serve as a competing endogenous RNA (ceRNA) for miR-133b, resulting in the upregulation of SOX4. 33854048 TMPO-AS1 LncRNA Homo sapiens Glioma cell lines interaction[Sponging miR-383-5p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found that TMPO-AS1 was up-regulated while miR-383-5p was down-regulated in glioma cell lines.In summary, our study revealed that inhibition of lncRNA TMPO-AS1 could suppress glioma progression through targeting miR-383-5p. TMPO-AS1 might be used as a therapeutic target for glioma treatment. Yes We found that TMPO-AS1 was up-regulated while miR-383-5p was down-regulated in glioma cell lines, and knockdown of TMPO-AS1 significantly suppressed glioma cell proliferation, migration and invasion abilities. 33262650 TMPO-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[ FOXK1-mediated AKT/mTOR signaling pathway] RNA Pull-Down//Western Blot//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay TMPO-AS1was upregulated in HCC tissues and cells and its depletion inhibits HCC cell proliferation, invasion, migration, and EMT process as well as tumor growth.TMPO-AS1 contributes to HCC progression by sponging miR-329-3p to activate FOXK1-mediated AKT/mTOR signaling pathway. Yes TMPO-AS1was upregulated in HCC tissues and cells and its depletion inhibits HCC cell proliferation, invasion, migration, and EMT process as well as tumor growth. 32462698 TMPO-AS1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cells regulation[LCN2 ] qRT-PCR We identified upregulated lncRNA TMPO-AS1 in ovarian cancer tissues and cells. Taken together, we demonstrated lncRNA TMPO-AS1 could potentially promote LCN2 transcriptional activity by binding to transcription factor E2F6, and thus, stimulated the progression of ovarian cancer. Yes siRNA-mediated silencing of lncRNA TMPO-AS1 restrained the aggressiveness of ovarian cancer cells and their pro-angiogenic ability, and reduced the expression of LCN2. 32692467 TMPO-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BLCA tissues Expression[highly expressed] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay By analyzing TCGA database and clinical samples, it was found that TMPO-AS1 was upregulated in BLCA tissues compared with that in normal bladder tissues. Worse survival was observed in BLCA patients with high expression of TMPO-AS1. TMPO-AS1 level was correlated to muscle invasiveness and TNM stage of BLCA patients. Yes In T24 and UMUC-3 cells, the knockdown of TMPO-AS1 suppressed proliferative and migratory abilities. 32964962 TMPO-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues and cell lines regulation[TMPO-AS1/miR-98-5p/EBF1 feedback loop] RNA Pull-Down//ChIP//Wound Healing Assay//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this study, high expression of TMPO-AS1 was revealed in BCa tissues and cell lines, and TMPO-AS1 predicted poor prognosis. Mechanistically, overexpressed EBF transcription factor 1 (EBF1) in BCa cell was verified to promote the transcription of TMPO-AS1. Later, we found that TMPO-AS1 was a cytoplasmic RNA and could sponge miR-98-5p. Besides, it was validated that EBF1 is a target gene of miR-98-5p and negatively correlated with miR-98-5p in terms of expression level. In this study, high expression of TMPO-AS1 was revealed in BCa tissues and cell lines, and TMPO-AS1 predicted poor prognosis. Yes Moreover, TMPO-AS1 facilitated cell growth. Additionally, TMPO-AS1 also boosted the migration and invasion of BCa cells. 32087328 TMPO-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Interaction(OTUB1-Induced E2F1 Deubiquitination) qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay TMPO-AS1 is upregulated in BC. Mechanically, E2F1 is responsible for TMPO-AS1 upregulation. Additionally, TMPO-AS1 facilitates the interaction of E2F1 with OTU domain-containing ubiquitin aldehyde binding 1 (OTUB1), leading to E2F1 deubiquitination and stabilization; therefore, TMPO-AS1 promotes BC malignant phenotypes. Yes Functional experiments demonstrated that TMPO-AS1 promotes cell proliferation, migration, and invasion in BC and inhibits cell apoptosis in vivo and in vitro. 33816295 TMPO-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction[miR-199a-5p/WNT7B axis ] qRT-PCR Our present study elucidated that a remarkable overexpression of TMPO-AS1 was found in OS tissues and cells. In a word, TMPO-AS1 serves as a competing endogenous RNA to boost osteosarcoma tumorigenesis by regulating miR-199a-5p/WNT7B axis, which provided an underlying therapeutic target for patients with OS. Yes Moreover, TMPO-AS1 depletion restrained Wnt/β-catenin pathway and cell proliferation as well as facilitated cell apoptosis. 31680323 TMPO-AS1 LncRNA Homo sapiens Osteosarcoma cell line interaction[targeting miR-329 and regulating E2F1] qRT-PCR//MTT//Luciferase Report Assay TMPO-AS1 was up-regulated in osteosarcoma cells. LncRNA-TMPO-AS1 can promote apoptosis of osteosarcoma cells by targeting miR-329 and regulating E2F1, which is a potent treatment option for osteosarcoma. Yes The results revealed that inhibited TMPO-AS1/overexpressed miR-329/inhibited E2F1 suppressed the proliferation and invasion of osteosarcoma cells and enhanced cell apoptosis. 33215415 TMPO-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer cells regulation[miR-143-3p/ZEB1 Axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay TMPO-AS1 was highly expressed in cervical cancer cells. Furthermore, TMPO-AS1 overexpression significantly promoted C-33A cell proliferation, migration, and invasion. TMPO-AS1 promotes cervical cancer cell proliferation, migration, and invasion by regulating the miR-143-3p/ZEB1 axis. Yes TMPO-AS1 was highly expressed in cervical cancer cells. Furthermore, TMPO-AS1 overexpression significantly promoted C-33A cell proliferation, migration, and invasion. In contrast, TMPO-AS1 silencing inhibited SiHa cell proliferation, migration, and invasion. 32184662 TMPO-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Interaction(miR-320a) In Vivo Experiment//Transfection//Immunoblotting//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay "We found that TMPO-AS1 was distinctly upregulated in NPC. Downregulation of TMPO-AS1 restrained aggressiveness-associated traits in NPC cells. Downregulation of TMPO-AS1 restrained aggressiveness-associated traits in NPC cells. Nevertheless, upregulation of TMPO-AS1 yielded the opposite results. Further studies revealed that lncRNA TMPO-AS1 acts as a ""sponge"" for miR-320a, resulting in increased levels of SOX4 in NPC cells. Finally, TMPO-AS1 silencing suppressed tumor growth of NPC cells in vivo." Yes "Downregulation of TMPO-AS1 restrained aggressiveness-associated traits in NPC cells. Nevertheless, upregulation of TMPO-AS1 yielded the opposite results. Further studies revealed that lncRNA TMPO-AS1 acts as a ""sponge"" for miR-320a, resulting in increased levels of SOX4 in NPC cells. Finally, TMPO-AS1 silencing suppressed tumor growth of NPC cells in vivo." 33488123 TMPO-AS1 LncRNA Homo sapiens gallbladder carcinoma GBC tissues and cell lines Interaction(microRNA-1179/E2F2 axis) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//IF//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay In the present study, lncRNA TMPO-AS1 was significantly upregulated in clinical GBC tissues and cell lines, and was highly expressed in stage III+IV patients with GBC compared with stage I+II patients with GBC. Taken together, the results of the present study suggest that TMPO-AS1 potentially plays a tumor-promoting role in the occurrence and development of GBC, which may be achieved by regulating the miR-1179/E2F2 axis. In addition, the overall survival rate of patients with low TMPO-AS1 expression levels was higher than those with high TMPO-AS1 expression levels. Yes Furthermore, TMPO-AS1 knockdown inhibited the viability, proliferation, migration, invasion and EMT of GBC cell lines. In addition, miR-1179 expression was downregulated in clinical GBC tissues and cell lines, and negatively correlated with TMPO-AS1 expression. 34777589 TMPO-AS1 LncRNA Homo sapiens Thyroid Neoplasms TC tissues and cell lines regulation[miR-498,TMPO] RNA Pull-Down//Western Blot//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining TMPO-AS1 was overexpressed in TC tissues and cell lines.TMPO-AS1 promotes cell proliferation in TC via sponging miR-498 to modulate TMPO. Yes Knockdown of TMPO-AS1 suppressed cell growth and accelerated cell apoptosis in TC. 32669970 TMPO-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues cell lines regulation[Modulating miR-326/SOX12 Axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay TMPO-AS1 was up-regulated in LUAD tissues as well as cell lines. TMPO-AS1 can modulate LUAD cell proliferation through E2F1/miR-326/SOX12 pathway. TMPO-AS1 expression was positively correlated with poor prognosis and pathological stage in LUAD. Yes Down-regulation of TMPO-AS1 could restrain the proliferation of LUAD cells through arresting the cell cycle at G0/G1 phase and inducing apoptosis in vitro. 33293866 TMPO-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines regulation[miR-383-5p] qRT-PCR//Luciferase Report Assay//RIP Herein, in our study, we identified that lncRNA TMPO-AS1 is significantly upregulated in LUAD tissues and cell lines.Next, we implemented online database analysis tools to find that mir-383-5p could target TMPO-AS1, and our data showed that TMPO-AS1 was negatively correlated with mir-383-5p in LUAD specimens. Yes Knockdown of TMPO-AS1 remarkably suppressed LUAD cell growth, induced apoptosis as well as G1/S arrest, and inhibited LUAD cell invasion, whereas overexpression of TMPO-AS1 exerts the opposite effects. 32062549 TMPO-AS1 LncRNA Homo sapiens Retinoblastoma cancerous tissues interaction[miR-199a-5p] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay "TMPO-AS1 was significantly up-regulated in cancerous tissues of RB samples (relatively expression: 2.97 vs 3.93, p < 0.001), negatively correlated with miR-199a-5p (r=-0.4813, p < 0.01). TMPO-AS1 is abnormally up-regulated in RB tissues, and it can modulate the proliferation and migration of RB cells. It has the potential to be the ""ceRNA"" to regulate HIF-1α expression by sponging miR-199a-5p." Yes There was one binding site on TMPO-AS1 for miR-199a-5p. After transfection of TMPO-AS1 shRNAs into RB cells, the proliferation, migration and invasion of cancer cells was significantly inhibited, while TMPO-AS1 had opposite effects; TMPO-AS1 was also demonstrated to regulate the expression of HIF-1α on both mRNA and protein levels via negatively regulating miR-199a-5p. 32139259 TMPO-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues Interaction(TMPO-AS1-miR-140/miR-143 axis ) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay The long non-coding RNA TMPO-AS1 was found to be overexpressed in EC tissues and to be negatively associated with EC patient outcomes. RNA-immunoprecipitation and luciferase reporter assays confirmed that TMPO-AS1 elevated GLUT1 expression by directly binding to two critical tumor suppressor microRNAs (miR-140 and miR-143). Yes Downregulation of TMPO-AS1 remarkably reduced EC cell proliferation, invasion, glycolysis, and paclitaxel resistance in EC cells. This study established that dysregulation of the TMPO-AS1-miR-140/miR-143 axis contributes to glycolysis and drug resistance in EC cells by up-regulating GLUT1 expression. 35712514 TMPO-AS1 LncRNA Homo sapiens Pancreatic Carcinoma pancreatic carcinoma tissues and cells Interaction(miR-383-5p/SOX11) In Vivo Experiment//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay Upregulation of lncRNA TMPO-AS1 was revealed in pancreatic carcinoma tissues and cells. In addition, microRNA (miR)-383-5p acted as a 'sponge' for lncRNA TMPO-AS1. The expression levels of lncRNA TMPO-AS1 and miR-383-5p were mutually inhibited in pancreatic carcinoma. Moreover, miR-383-5p was revealed to directly target SRY-related high-mobility group box 11 (SOX11). Notably, SOX11 could promote the occurrence of pancreatic carcinoma by interacting with the lncRNA TMPO-AS1/miR-383-5p axis. Yes Furthermore, knockdown of TMPO-AS1 restrained cell proliferation and motility in pancreatic carcinoma. 33664819 TMPO-AS1 LncRNA Homo sapiens Polycystic Ovary Syndrome Follicular fluid Interaction(miR-355-5p) BrdU//qRT-PCR//Transfection//RNA Pull-Down TMPO-AS1 was increased in PCOS, while mature miR-355-5p was decreased in PCOS. TMPO-AS1 overexpression decreased mature miR-355-5p level but increased premature miR-355-5p. TMPO-AS1 directly interacted with premature miR-355-5p in KGN cells. TMPO-AS1 increased KGN cell proliferation while miR-355-5p decreased cell proliferation. The co-transfection assay showed that TMPO-AS1 reduced the suppressive effects of miR-355-5p on cell proliferation. Yes TMPO-AS1 increased KGN cell proliferation while miR-355-5p decreased cell proliferation. The co-transfection assay showed that TMPO-AS1 reduced the suppressive effects of miR-355-5p on cell proliferation. 34330309 TMPO-AS1 LncRNA Homo sapiens lung carcinoma LC tissues and cells Interaction( miR-143-3p/CDK1 Axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay TMPO-AS1 and CDK1 were overexpressed in LC tissues and cells, while miR-143-3p level was suppressed. The decrease of TMPO-AS1 led to the increase of miR-143-3p, which further resulted in the reduction of CDK1. Simultaneously, siCDK1 could reverse the anti-apoptosis and pro-activity functions of miR-143-3p inhibitor in LC cells. Down-regulation of TMPO-AS1 has the effects of pro-apoptosis in LC by manipulating miR-143-3p/CDK1, which is hopeful to be a novel therapy for LC patients. Yes Down-regulating TMPO-AS1 reduced LC cell viability, motivated cell apoptosis, as well as promoted the expressions of Bcl and CCND1 and restrained Caspase-3 level, but all these consequences were abrogated by miR-143-3p inhibitor. 33685293 TLK1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC samples Interaction(miR-138-5p) Western Blot//Transfection//qPCR//IF//MTT//PCR//Transwell Assay We observed that circ-TLK1 was highly expressed in HCC samples, and its high expression was closely associated with poor clinicopathological variables of HCC patients. The results of functional experiments revealed that knockdown of circ-TLK1 remarkably inhibited the proliferation, migration, invasion, and EMT of HCC cells, while circ-TLK1 overexpression promoted these malignant behaviors. Moreover, we noted that circ-TLK1 was capable of binding to miR-138-5p and upregulating its target gene, SOX4 in HCC. Based on rescue assays, miR-138-5p inhibition partially suppressed the effects of circ-TLK1 knockdown on the malignant behaviors of HCC cells. We observed that circ-TLK1 was highly expressed in HCC samples, and its high expression was closely associated with poor clinicopathological variables of HCC patients. Yes The results of functional experiments revealed that knockdown of circ-TLK1 remarkably inhibited the proliferation, migration, invasion, and EMT of HCC cells, while circ-TLK1 overexpression promoted these malignant behaviors. 35359342 TINCR LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(miR-503-5p/STAT3-TINCR-EGFR-feedback loop) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Viability Assay//Colony Formation Assay//Invasion Assay TINCR is upregulated in human breast cancer tissues, and TINCR knockdown suppresses tumorigenesis in vitro and in vivo. Mechanistically, TINCR recruits DNMT1 to the miR-503-5p locus promoter, which increases the methylation and suppresses the transcriptional expression of miR-503-5p. Furthermore, TINCR also functions as a competing endogenous RNA to upregulate EGFR expression by sponging miR-503-5p. In addition, TINCR stimulates JAK2-STAT3 signaling downstream from EGFR, and STAT3 reciprocally enhances the transcriptional expression of TINCR. Yes TINCR is upregulated in human breast cancer tissues, and TINCR knockdown suppresses tumorigenesis in vitro and in vivo. 33446634 TINCR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[downregulated miR-21] qRT-PCR PLAC2 was down-regulated, while miR-21 was up-regulated in NSCLC tissues compared to non-cancer tissues. PLAC2 and miR-21 were inversely correlated, and PLAC 2 over-expression in NSCLC cells resulted in the down-regulation of miR-21. However, miR-21 over-expression did not significantly affect PLAC2 expression. PLAC2 over-expression resulted in decreased migration and invasion rates of NSCLC cells. MiR-21 over-expression played the opposite role and attenuated the effects of PLAC2 over-expression. Low PLAC2 levels in NSCLC tissues were associated with poor survival of NSCLC patients. Yes PLAC2 over-expression resulted in decreased migration and invasion rates of NSCLC cells. 31500623 THORLNC LncRNA Homo sapiens Breast Neoplasms BRCA tissues Interaction(THOR-hnRNPD-PDK1-MAPK/PI3K-AKT axis) RNA Pull-Down//IHC//Western Blot//ISH//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Colony Formation Assay//Invasion Assay//Transwell Assay THOR expression was significantly higher in BRCA tissues than in normal tissues, and THOR upregulation was associated with a poor prognosis in BRCA patients. Mechanistically, THOR bound to the hnRNPD protein and increased hnRNPD protein levels by maintaining hnRNPD protein stability through inhibition of the proteasome-dependent degradation pathway. The increased hnRNPD protein levels led to stabilization of its target mRNAs, including pyruvate dehydrogenase kinase 1 (PDK1), further activating downstream PI3K-AKT and MAPK signaling pathways to regulate BRCA cell proliferation and metastasis. THOR expression was significantly higher in BRCA tissues than in normal tissues, and THOR upregulation was associated with a poor prognosis in BRCA patients. Yes Functionally, THOR knockdown impaired cell proliferation, migration and invasion in BRCA cells in vitro and inhibited tumorigenesis and metastasis in a tumor xenograft model and THOR-deficient MMTV-PyMT model in vivo. 36329124 TILR LncRNA Homo sapiens Lung Neoplasms Cell lines Interaction(PCBP2/p53) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//Microarray Taken together, the present findings clearly demonstrate that TILR constitutively inhibits p53 expression in cooperation with PCBP2, thus maintaining p53 transcriptional activity at a level sufficiently low for avoidance of spurious apoptosis induction. Yes In addition, depletion of PCBP2 resulted in phenocopied effects of TILR silencing. TILR was also shown to suppress p53 expression in a post-transcriptional manner, as well as via a positive feedback loop involving p53 and Fanconi anemia pathway genes. 36522487 THUMPD3-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines Interaction[microRNA-543 ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay Overexpression and knockdown analysis revealed that THUMPD3-AS1 promoted tumor progression by increasing cell proliferation and self-renewal of NSCLC cells. Moreover, THUMPD3-AS1 may act as an endogenous sponge of microRNA-543 (miR-543) which can regulate the target gene ONECUT2 in NSCLC cells. Yes Overexpression and knockdown analysis revealed that THUMPD3-AS1 promoted tumor progression by increasing cell proliferation and self-renewal of NSCLC cells. 31819483 THUMPD3-AS1 LncRNA Homo sapiens Osteoarthritis knee normal and OA cartilage tissue Regulation(highly expressed) CCK8//ELISA//Flow Cytometry//Western Blot lncRNA THUMPD3-AS1 was downregulated in OA cartilage tissues and IL-1β-stimulated chondrocyte cell line. Overexpression of lncRNA THUMPD3-AS1 alleviated cell apoptosis and facilitated inflammatory responses, whereas knockdown had opposite effects. LncRNA THUMPD3-AS1 markedly increased the cyclin E2, cyclin-dependent kinase 4, B-cell lymphoma 2, tumor necrosis factor-α, nitric oxide, and IL-6 levels, and decreased the caspase-3 level. Furthermore, the target proteins of phosphorylation were identified as nuclear factor-κB p65 and mitogen-activated protein kinase p38, which could be indirectly suppressed by lncRNA THUMPD3-AS1 knockdown. Yes lncRNA THUMPD3-AS1 was downregulated in OA cartilage tissues and IL-1β-stimulated chondrocyte cell line. Overexpression of lncRNA THUMPD3-AS1 alleviated cell apoptosis and facilitated inflammatory responses, whereas knockdown had opposite effects.the target proteins of phosphorylation were identified as nuclear factor-κB p65 and mitogen-activated protein kinase p38, which could be indirectly suppressed by lncRNA THUMPD3-AS1 knockdown. 34509934 THRIL LncRNA Homo sapiens Osteosarcoma OS tissues and serum regulation[THRIL/TNF-α signal ] qRT-PCR Elevated expression of THRIL was associated with increased TNF-α levels in OS tissues and serum samples.THRIL/TNF-α signal supported cell growth and EMT phenotype of OS cells in vitro and in vivo. Moreover, high-expressed THRIL was associated with larger tumor size, advanced Enneking stage and lung metastasis, whereas high TNF-α expression was found in patients with high histologic grade and patients who simultaneously harbor high THRIL and TNF-α showed the worst overall survival and metastasis-free survival. Yes TNF-α signals increased OS cell vitalities in vitro but knockdown of THRIL inhibited TNF-α expressions, leading to impaired cell vitality, increased apoptosis and also downregulated epithelial to mesenchymal transition (EMT) phenotype and the ability of invasion, but these processes were restored by the treatment of TNF-α. 32021260 THRIL LncRNA Homo sapiens Arthritis, Rheumatoid synovial tissue (ST) specimens from RA patients with active disease (n=10, 7 females and 3 males; age range: 46–61 years) and osteoarthritis patients (n=5, 3 females and 2 males; age range: 54–66 years) Expression [highly expressed] Transfection//EdU Staining//Migration Assay//qRT-PCR//Cell Apoptosis Assay//Invasion Assay A significant decrease in THRIL expression was found in RA FLSs compared with cells from healthy control (HC)patients. THRIL is mainly localized in the nucleus. Yes Knockdown of THRIL increased the proliferation, migration, and invasion of RA FLSs. In contrast, THRIL overexpression had the opposite effect. 34733920 THRIL LncRNA Mus musculus Coronary Disease myocardial tissues Interaction(miR-424/TXNIP/p53 axis) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Microarray//Bioinformatics Analysis The results showed that treating CHD mice with si-THRIL attenuated myocardial damage by restoring LVEF, LVFS, and HDL-C levels, while lowering HMI, LVMI, TC, TG, LDL-C, CK-MB, and cTnI levels. Meanwhile, mechanistical studies using bioinformatics prediction, dual-luciferase and subcellular fractionation assays revealed that THRIL bound to microRNA (miR)-424, inhibited miR-424 interaction with TXNIP and promoted TXNIP expression in the myocardial tissues. Taken together, this study demonstrated that THRIL inhibition alleviates myocardial injury in CHD possibly through the miR-424/TXNIP/p53 axis. Yes The results showed that treating CHD mice with si-THRIL attenuated myocardial damage by restoring LVEF, LVFS, and HDL-C levels, while lowering HMI, LVMI, TC, TG, LDL-C, CK-MB, and cTnI levels. 34171363 THRIL LncRNA Mus musculus Lung Injury lung tissues regulation[ miR-424/ROCK2 axis] qRT-PCR//Luciferase Report Assay Our results showed that THRIL was highly expressed in the lung of sepsis mice. Overall, in vivo and in vitro results suggested that THRIL accelerates sepsis-induced lung injury by sponging miR-424 and further restoring ROCK2. Yes CLP triggered severe lung injury and apoptosis in mice, which was abolished by THRIL knockdown. 32818819 THRIL LncRNA Mus musculus Cerebral Ischaemia/Reperfusion Injury models of brain ischemia-reperfusion injury Interaction(miR-24-3p/NRP1/NF-κB p65 signaling pathway) Western Blot//Transfection//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//ELISA//IF THRIL was upregulated in both in vitro and in vivo models of brain ischemia-reperfusion injury. THRIL targeted and regulated the expression of miR-24-3p/neuropilin-1 (NRP1) axis. THRIL silencing significantly improved the neurological functioning of rats in the MCAO/R model by miR-24-3p/NRP1/NF-κB p65 signaling pathway. Yes Knockdown of THRIL attenuated OGD/R neuronal apoptosis and OGD/R-induced inflammation. THRIL targeted and regulated the expression of miR-24-3p/neuropilin-1 (NRP1) axis. THRIL silencing significantly improved the neurological functioning of rats in the MCAO/R model by miR-24-3p/NRP1/NF-κB p65 signaling pathway. 33675584 THORLNC LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung primary NSCLC cells and established cell lines Interaction(IGF2BP1) RNA Pull-Down//Western Blot//Tunel//RIP//qRT-PCR//ELISA In primary NSCLC cells and established cell lines, Lnc-THOR shRNA or CRISPR/Cas9-mediated knockout (KO) downregulated IGF2BP1 target mRNAs (IGF2, Gli1, Myc and SOX9), inhibiting cell viability, growth, proliferation, migration and invasion. Yes In primary NSCLC cells and established cell lines, Lnc-THOR shRNA or CRISPR/Cas9-mediated knockout (KO) downregulated IGF2BP1 target mRNAs (IGF2, Gli1, Myc and SOX9), inhibiting cell viability, growth, proliferation, migration and invasion. 34868966 TINCR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[TINCR/miR-107/CD36 axis] Flow Cytometry//qRT-PCR//Luciferase Report Assay//EdU Staining The expression levels of the TINCR and CD36 were down-regulated. MiR-107 overexpression in CRC cells induced proliferation and impeded apoptosis. A regulatory function of the lncRNA TINCR/miR-107/CD36 axis in CRC was revealed. LncRNA TINCR overexpression exerted suppressive influence on CRC progression through modulating the PPAR signaling pathway via the miR-107/CD36 axis. Yes The expression levels of the TINCR and CD36 were down-regulated. 30521471 THORLNC LncRNA Homo sapiens Colonic Neoplasms cell line(SW620) Regulation[Expression[Expression[highly expressed]-expression]-regulated] CCK8//EdU Staining//Transwell Assay lncRNA THOR, as an oncogene, promotes the proliferation and migration of colon cancer cells, which can be used as a therapeutic target for colon cancer treatment. Yes At cellular level, lncRNA THOR knockExpression[down-expression] led to significantly inhibited proliferation and migration of colon cancer SW620 cells. At animal level, lncRNA THOR knockExpression[down-expression] mediated the significantly inhibited growth of tumors in mice. It indicated that lncRNA THOR plays an important role in the development of colon cancer. 31452739 THORLNC LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues and established/primary human RCC cells Regulation[up-regulation] qRT-PCR Here, we show that THOR is expressed in human renal cell carcinoma (RCC) tissues and established/primary human RCC cells. Yes THOR silencing (by targeted siRNAs) or CRISPR/Cas9 knockout inhibited RCC cell growth, viability and proliferation in vitro. 29752937 THORLNC LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation[PTEN/AKT pathway] qRT-PCR In this study, we found that THOR was relatively highly expressed in human HCC tissues and cell lines. Mechanistically, THOR drives HCC cell progression via the PTEN/AKT pathway. Notably, high THOR expression was associated with worse prognosis. Yes THOR depletion resulted in significant inhibition of the growth and metastasis of HCC cells. 30098425 THORLNC LncRNA Homo sapiens Ovarian Neoplasms OC tissues regulation[IL-6/STAT3 pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Invasion Assay In this study, our results find that THOR is markedly upregulated in human OC tissues and predicts the poor prognosis of OC patients. Our findings reveal that THOR could promote OC cells growth, metastasis and self-renewal by activating IL-6/STAT3 signaling and may be a good predictive factor and therapeutic target. In this study, our results find that THOR is markedly upregulated in human OC tissues and predicts the poor prognosis of OC patients. Yes Functional studies have revealed that knockdown of THOR inhibits the growth, metastasis and self-renewal of OC cells. 32552789 THORLNC LncRNA Homo sapiens Osteosarcoma cell lines Interaction[enhancing SOX9 mRNA stability] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Mechanistically, mRNA stability, luciferase reporter, and RNA-RNA in vitro interaction assays indicated that THOR can directly bind to the middle region of the SOX9 3'-untranslated region (UTR), and enhances its mRNA stability, thereby increasing its expression. Notably, SOX9 knockdown reduced the ability of THOR overexpression to promote the stemness of OS cells. Yes THOR overexpression increased spheroid formation ability and aldehyde dehydrogenase 1 (ALDH1) activity in OS adherent cells, and the opposite effect was observed in spheroids with THOR knockdown. 31169973 THORLNC LncRNA Homo sapiens Glioma glioma tissues Regulation[MAGEA6-AMPK signaling ] RNA Pull-Down//Western Blot//qPCR//RIP//MTT//Cell Apoptosis Assay//Cell Proliferation Assay//Transwell Assay As described in our previous studies21, a total of five pairs of human glioma tissues (“T”) and paired surrounding normal brain tissues (“N”) were analyzed, and qPCR assay results in Fig. ​Fig.1a1a show that Lnc-THOR levels are high in human glioma tissues, whereas its levels in normal brain tissues are, however, extremely low (Fig. ​(Fig.1a).1a). Taken together, Lnc-THOR depletion inhibits human glioma cell survival possibly by activating MAGEA6-AMPK signaling. Yes In vivo, Lnc-THOR silencing or knockout potently inhibited subcutaneous A172 xenograft tumor growth in mice. 31727877 THORLNC LncRNA Homo sapiens Endometrial Neoplasms clinical sample Interaction(IGF2BP1/AKT and ERK ) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Invasion Assay//Transwell Assay THOR expression based on The Cancer Genome Atlas (TCGA) and clinical sample analyses was significantly higher in EC tissues than normal tissues, and higher THOR levels were closely associated with poor overall survival in EC. Moreover, IGF2BP1 protein expression and ERK and AKT protein phosphorylation levels in EC cells increased significantly with THOR overexpression in EC cells. In conclusion, our findings suggest that THOR promotes EC cell growth and invasion, and IGF2BP1-mediated AKT and ERK signaling pathways activation might be involved. THOR expression based on The Cancer Genome Atlas (TCGA) and clinical sample analyses was significantly higher in EC tissues than normal tissues, and higher THOR levels were closely associated with poor overall survival in EC. Yes CCK-8, colony formation, and transwell migration and invasion assays revealed that THOR significantly enhances the proliferation, migration, and invasion abilities of EC cells. 36175594 THEMIS2-211 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(THEMIS2-211/miR-940/SPOCK1 axis) qRT-PCR Here, the diagnostic value of a panel based on exosomal lncRNA THEMIS2-211 and PRKACA-202, superior to that of AFP, was identified for diagnosing human HCC. Besides, the performance of exosomal lncRNA THEMIS2-211 alone exceeds that of AFP in diagnosing early-stage HCC patients (stage I). Furthermore, lncRNA THEMIS2-211 is highly expressed in HCC tissues and correlated with the poor prognosis of HCC patients. LncRNA THEMIS2-211 is upregulated and localized in the cytoplasm of HCC cells. LncRNA THEMIS2-211 exerts its biological function as an oncogene that promotes the proliferation, migration, invasion, EMT of HCC cells by physically interacting with miR-940 and therefore promoting SPOCK1 expressions. Rescue assays show the regulation of SPOCK1 by lncRNA THEMIS2-211 dependents on miR-940. The discovery of lncRNA THEMIS2-211 further illuminates the molecular pathogenesis of HCC and the THEMIS2-211/miR-940/SPOCK1 axis may act as a potential therapeutic target for HCC. Furthermore, lncRNA THEMIS2-211 is highly expressed in HCC tissues and correlated with the poor prognosis of HCC patients. LncRNA THEMIS2-211 is upregulated and localized in the cytoplasm of HCC cells. Yes LncRNA THEMIS2-211 exerts its biological function as an oncogene that promotes the proliferation, migration, invasion, EMT of HCC cells by physically interacting with miR-940 and therefore promoting SPOCK1 expressions. Rescue assays show the regulation of SPOCK1 by lncRNA THEMIS2-211 dependents on miR-940. 35224785 TINCR LncRNA Homo sapiens Melanoma CMM tissues and tested cell lines Interaction(miR‑424‑5p/LATS1 axis ) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay Moreover, in the collected CMM tissues and tested cell lines of the current study, TINCR expression was found to be downregulated compared with the respective controls. LATS1, a target of miR‑424‑5p, was found to be positively regulated by TINCR. TINCR activated Hippo signaling and repressed the activity of Yes 1 associated transcriptional regulator by regulating LATS1 expression, while LATS1 knockdown reversed the effect of TINCR overexpression on CMM cells. Yes Notably, TINCR overexpression inhibited the expression levels of CTGF, CCN1 and AXL, decreased the proliferation and invasion, and induced the apoptosis of CMM cell lines. 34542165 TINCR LncRNA Homo sapiens Breast Neoplasms serum of patients with early TNBC Interaction(miR-761) RNA Pull-Down//Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Invasion Assay Both TINCR and miR-761 were up-regulated in the serum of patients with early TNBC and the area under the curve (AUC) of the two for distinguishing TNBC from BC was not less than 0.850. We also confirmed that TINCR acts as the molecular sponge of miR-761, and has positive regulation on it. Besides, LU can significantly down-regulate TINCR and miR-761, and partially offset the anti-TNBC activity of LU when they were abnormally up-regulated, which was mainly reflected in the decrease of anti-proliferation and pro-apoptotic ability of LU against TNBC. Yes In the cell function tests, down-regulation of TINCR or miR-761 notably suppressed the metastatic potentials (cell migration, invasion and EMT) of TNBC cells were remarkably inhibited, while up-regulation of TINCR or miR-761 notably promoted the metastatic potentials. 33654432 TINCR LncRNA Homo sapiens Urinary Bladder cancerous tissues interaction[Hsa-miR-125b ] qRT-PCR//Wound Healing Assay//ELISA//Luciferase Report Assay The expression levels of TINCR were higher in cancerous tissues than that in paired noncancerous tissues of UCB. Hsa-miR-125b is a target for TINCR in UCB. Higher expression levels of TINCR were positively associated with high-grade, invasive, and recurring tumors. Yes Depletion of TINCR retarded proliferation, decreased motility, increased apoptosis in UCB cells, and markedly reduced tumor growth in xenograft nude mice. 32622721 TINCR LncRNA Homo sapiens Diabetes Mellitus IECs Interaction(miR-668-3p/Klf3) ISH//qRT-PCR//Luciferase Report Assay//Microarray//Bioinformatics Analysis In this study, we observed that the level of lncRNA Tincr was increased in IECs in the DM state. More importantly, Tincr was associated with abnormal intestinal epithelial stem cell (IESC) differentiation in DM. Our mechanistic study demonstrated that Tincr is a major marker of Lgr5+ stem cells in DM. In addition, we investigated whether Tincr directly targets miR-668-3p and whether miR-668-3p targets Klf3. Our findings showed that Tincr sponged miR-668-3p, which attenuated abnormal IESC differentiation in DM by regulating Klf3 expression. Yes Furthermore, NEAT1 silencing inhibited renal fibrosis and inflammation and suppressed the RhoA/ROCK1 signaling pathway. NEAT1 silencing or overexpression of miR-31 alleviated renal fibrosis in vivo. 35362387 TINCR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[upregulates p53] qRT-PCR//Western Blot Our data showed that PLAC2 expression in HCC was not affect by HCV and HBV infection, while PLAC2 levels were significantly lower in HCC tissues comparing to non-cancer tissues.P53 mRNA was also downregulated in HCC and positively correlated with PLAC2. PLAC2 overexpression caused upregulated p53 and increase cancer cell apoptosis. P53 overexpression failed to affect PLAC2. In addition, p53 silencing reduced the effects of PLAC2 overexpression. Therefore, PLAC2 upregulated p53 to mediate cancer cell apoptosis. Low PLAC2 levels in HCC tissues were associated with low overall 5-year survival rate. Yes PLAC2 overexpression caused upregulated p53 and increase cancer cell apoptosis. 31233763 TINCR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-195-3p/ST6GAL1/NF-κB pathway) qRT-PCR TINCR was upregulated in HCC and associated with poor patient prognosis. Mechanistically, TINCR acted as a competing endogenous (ceRNA) to sponge miR-195-3p, relieving its repression on ST6GAL1, and activated nuclear factor kappa B (NF-κB) signaling. TINCR was upregulated in HCC and associated with poor patient prognosis. Yes Silencing TINCR inhibited HCC proliferation, migration, invasion, and oxaliplatin resistance while overexpressing TINCR showed opposite above-mentioned functions. The mouse xenograft experiment further verified that knockdown TINCR attenuated tumor progression and oxaliplatin resistance in vivo. 34980201 TINCR LncRNA Homo sapiens Carcinoma, Hepatocellular liver cancer tissues and cell lines Interaction(miR-375/ATG7 Axis) qRT-PCR The lncRNA TINCR was highly expressed in liver cancer tissues and cell lines. miR-375 negatively affected the expression of ATG7. The lncRNA TINCR bound to miR-375 and influenced its expression. Transfection of miR-375 mimics greatly inhibited the inhibitory effect of lncRNA TINCR knockdown on the invasion and proliferation, whereas transfection of miR-375 inhibitor considerably reverses this effect on liver cancer cells. Yes Liver cancer cells responded differently to knockdown of the lncRNA TINCR compared to overexpression in terms of proliferation, colony formation, and invasion. Overexpressing lncRNA TINCR increased liver cancer cell proliferation in vivo. 36157234 TINCR LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cell lines regulation[miR-7 and mTOR] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot The present study found that the expression of TINCR was significantly increased in bladder cancer tissues and cell lines, when compared with that in adjacent normal tissues and normal urinary tract epithelial cell line SV?HUC?1, respectively. Moreover, the high expression of TINCR was associated with tumor metastasis and advanced tumor, node, metastasis stage, as well as reduced overall survival rates of patients with bladder cancer. Yes Silencing of TINCR expression significantly increased miR?7 expression and reduced bladder cancer cell proliferation, migration and invasion, while knockdown of miR?7 expression reversed the inhibitory effects of TINCR downregulation on bladder cancer cells. 33000269 TINCR LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues regulation[miR-663,TGF-β1] qRT-PCR Our data showed that the expression levels of PLAC2 were significantly lower in BC tissues than that in non-cancer tissues. PLAC2 can upregulate miR-663 to downregulate TGF-β1 and suppress BC cell migration and invasion. The expression of PLAC2 was not affect by clinical stages and low expression levels of PLAC2 predicted lower survival rate. Yes Overexpression of PLAC2 also resulted in suppressed invasion and migration of BC cells. 32650766 TINCR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues, cell lines Regulation[Wnt/β‑catenin signaling pathway] Western Blot//Migration Assay//CCK8//qRT-PCR//FISH//Invasion Assay//ChIP A reverse transcription‑quantitative polymerase chain reaction assay identified that PLAC2 is upregulated in OSCC cell lines and primary tissue samples. In conclusion, the present results indicated that lncRNA PLAC2 is transcriptionally activated by H3K27ac modification at the promoter region in OSCC, and promotes cell growth and metastasis via activating Wnt/β‑catenin signaling pathway. Therefore, PLAC2 may serve as a promising biomarker for OSCC prognosis and therapy. Yes Functionally, overexpression of PLAC2 promotes OSCC cell proliferation, migration and invasion, whereas knockdown of PLAC2 exerted an opposite effect. 30720068 TINCR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues regulation[ JAK2/STAT3 signaling] qRT-PCR qRT-PCR analyses validated down-regulation of TINCR in tumor tissues compared with paired NATs, and its expression was closely correlated with pathological differentiation and lymph node metastasis in patients with OSCC. Our study suggests that TINCR functions as a tumor suppressor by inducing cell differentiation through modulating JAK2/STAT3 signaling in OSCC. TINCR may serve as a prognostic biomarker and therapeutic target for OSCC. qRT-PCR analyses validated down-regulation of TINCR in tumor tissues compared with paired NATs, and its expression was closely correlated with pathological differentiation and lymph node metastasis in patients with OSCC. Patients with lower TINCR expression levels had worse survival. Yes Overexpression of TINCR dramatically suppressed cell dedifferentiation, migration and invasion in vitro, while knockdown of TINCR had the opposite effects. Upregulation of TINCR significantly elevated the expression of terminal differentiation genes and repressed tumor growth in vivo. 33732637 TINCR LncRNA Homo sapiens Osteosarcoma OS tissues regulation[miR-93] CCK8//qRT-PCR Our results showed that PLAC 2 was downregulated in OS tissues, and the high expression levels of PLAC 2 were associated with favorable overall survival of OS patients. PLAC 2 is downregulated in OS and regulates cancer cell proliferation through miR-93. Our results showed that PLAC 2 was downregulated in OS tissues, and the high expression levels of PLAC 2 were associated with favorable overall survival of OS patients. Yes Overexpression of PLAC 2 led to decreased proliferation rate of OS cells, while overexpression of miR-93 showed opposite roles and reduced the overexpressing effects of PLAC 2. 32547199 TINCR LncRNA Homo sapiens Nasopharyngeal carcinoma nasopharynx tissues Expression[highly expressed] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//FISH//ELISA Here we report that lncRNA TINCR was significantly upregulated in NPC and was associated positively with poor survival. Here we report that lncRNA TINCR was significantly upregulated in NPC and was associated positively with poor survival. Yes Silencing TINCR inhibited NPC progression and cisplatin resistance. 33067266 TINCR LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction[miR-107/miR-1286 ] qRT-PCR//Wound Healing Assay//Transwell Assay Results indicated that TINCR was evidently downregulated in LUAD.These data revealed a possible regulatory mechanism in which upregulation of TINCR induced by Sp1 could constrain the migration and invasion through regulating miR-107 or miR-1286 in LUAD cells. The association between TINCR and clinicopathological parameters was analyzed by Pearson's chi-square test, suggesting TINCR was closely correlated with TNM stage and lymph mode metastasis. Yes Subsequently, the function role of TINCR was examined by gain- and loss-of-function studies in LUAD (A549 and NCI-H292) cells. 31497197 TINCR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck laryngeal squamous cell carcinoma (LSCC) tissues and cells Interaction(miR-210/BTG2) In Vivo Experiment//Wound Healing Assay//Cell Proliferation Assay//Cell Cycle Assay//Transwell Assay We used qRT-PCR to detect the expression of TINCR in laryngeal squamous cell carcinoma (LSCC) tissues and cells and found significantly lower levels in cancer tissues compared with adjacent tissues. Overexpression of miR-210 was determined to reverse the tumour-suppressive effects of TINCR. BTG2 (anti-proliferation factor 2) was identified as the target gene of miR-210, and BTG2 overexpression inhibited the proliferation and invasion of LSCC cells. BTG2 knockdown relieved the inhibitory effects of TINCR on the proliferation and invasion of LSCC. Additionally, patients with high TINCR expression had a better prognosis. Yes TINCR overexpression was observed to inhibit the proliferation and invasion of LSCC cells. . TINCR was shown to exert its antiproliferation and invasion effects by adsorbing miR-210, which significantly promoted the proliferation and invasion of laryngeal squamous cells. Finally, TINCR upregulation slowed xenograft tumour growth in nude mice and significantly increased survival compared with control mice. 34187411 TINCR LncRNA Homo sapiens ovarian carcinoma OC tissues regulation[CDK2 ] CCK8//qRT-PCR//Colony Formation Assay//Western Blot The expression levels of PLAC2 and CDK2 were both upregulated in OC and they were positively correlated. PLAC2 positively regulates CDK2 to promote OC cell proliferation. ring the 5-year follow-up, patients with high levels of PLAC2 and CDK2 showed significantly lower overall survival rate. Yes Cell proliferation assay showed that overexpression of PLAC2 resulted in increased, while silencing of PLAC2 resulted in decreased proliferation rate of OC cells. 32765074 TINCR LncRNA Homo sapiens Melanoma metastatic melanoma tissues Interaction(ATF4) In Vivo Experiment//qPCR//RNA-seq//Western Blot Here, we report that the lncRNA TINCR is down-regulated in metastatic melanoma and its silencing increases the expression levels of invasive markers, in vitro migration, in vivo tumor growth, and resistance to BRAF and MEK inhibitors. The critical mediator is ATF4, a central player of the integrated stress response (ISR), which is activated in TINCR-depleted cells in the absence of starvation and eIF2α phosphorylation. TINCR depletion increases global protein synthesis and induces translational reprogramming, leading to increased translation of mRNAs encoding ATF4 and other ISR proteins. Yes Here, we report that the lncRNA TINCR is down-regulated in metastatic melanoma and its silencing increases the expression levels of invasive markers, in vitro migration, in vivo tumor growth, and resistance to BRAF and MEK inhibitors. 33586907 TINCR LncRNA Homo sapiens Liver Neoplasms HCC tissues and LCSCs Regulation(PTBP1/ATG5 regulatory pathway) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP In this study, TINCR was found to be highly expressed in HCC tissues and LCSCs. In vitro and in vivo assays for the first time showed that TINCR was required for LCSC self-renewal and tumorigenesis. Moreover, gene ontology analysis revealed the involvement of autophagy in the maintenance of TINCR-regulated stemness. Mechanically, TINCR was associated with polypyrimidine tract binding protein 1 (PTBP1) protein, which further promoted the transcription activity of autophagy related gene ATG5. In conclusion, we demonstrated that TINCR regulated LCSC self-renewal by autophagy activation through PTBP1/ATG5 regulatory pathway, offering a potential new target for HCC therapy. Yes Moreover, gene ontology analysis revealed the involvement of autophagy in the maintenance of TINCR-regulated stemness. Mechanically, TINCR was associated with polypyrimidine tract binding protein 1 (PTBP1) protein, which further promoted the transcription activity of autophagy related gene ATG5. 36385098 TINCR LncRNA Homo sapiens Cardiomegaly TAC- or Ang II-induced models of cardiac hypertrophy Interaction(miR-211-3p-VEGFB-SDF-1α-CXCR4 pathway) Western Blot//RIP//qRT-PCR//Luciferase Report Assay//IHC In our study, we have showed TINCR was downregulated and miR-211-3p was upregulated in TAC- or Ang II-induced models of cardiac hypertrophy. Mechanistically, we demonstrated that miR-211-3p directly targeted VEGFB and thus regulated the expression of SDF-1α and CXCR4. Yes Dual luciferase and RIP assays revealed that TINCR served as a competitive endogenous RNA (ceRNA) for miR-211-3p. Then, we observed that knockdown of miR-211-3p alleviated TAC- or Ang II-induced cardiac hypertrophy both in vivo and in vitro. 34732848 TINCR LncRNA Homo sapiens Polycystic Ovary Syndrome PCOS patient and cells Interaction(miR-19a/TNF-α) Western Blot//Transfection//qPCR//Luciferase Report Assay//Cell Apoptosis Assay The results showed that PLAC2 was upregulated in PCOS. PLAC2 and miR-19a showed a direct interaction, while overexpression of PLAC2 and miR-19a did not affect the expression of each other in KGN cells. Instead, overexpression of PLAC2 led to upregulated TNF-α, which is a target of miR-19a. Therefore, PLAC2 may regulate miR-19a/TNF-α to participate in PCOS. Yes Cell apoptosis analysis showed that PLAC2 and TNF-α promoted the apoptosis of KGN cells. Overexpression of miR-19a played an opposite role. In addition, the overexpression of PLAC2 reduced the effects of overexpression of miR-19a. 34967266 OIP5-AS1 LncRNA Homo sapiens Colonic Neoplasms CC tissues and matched normal tissues Interaction(miR-34b-5p targets HuR) CCK8//qRT-PCR//Colony Formation Assay OIP5-AS1 was highly expressed in CC and associated with poor prognosis. Collectively, miR-34b-5p targets HuR and miR-34b-5p binds to OIP5-AS1 with HuR, thus inhibiting OIP5-AS1 and PI3K/Akt pathway and CC progression. OIP5-AS1 was highly expressed in CC and associated with poor prognosis. Yes Silencing OIP5-AS1 inhibited CC cell malignant behaviors and inhibited the growth rate and tumor weight. In the mechanism, HuR bound to OIP5-AS1 and stabilized OIP5-AS1 expression. 34021273 SNHG16 LncRNA Homo sapiens Urinary Bladder Neoplasms BCa cells and BCa tissues regulation[miR-200a-3p/ ZEB1/ZEB2 axis] qRT-PCR//RNA Pull-Down//Western Blot//Transwell Assay SNHG16 was found up-regulated in TGF-β-induced BCa cells and BCa tissues.This study first demonstrated that SNHG16 was responsible for EMT of BCa cells via miR-200a-3p/ ZEB1/ZEB2 axis. Yes Transwell assay showed that overexpression of SNHG16 significantly promoted the migration and invasion of BCa cells, whereas knock-down of SNHG16 caused the opposite effects. 32207096 MCM3AP-AS1 LncRNA Homo sapiens Carcinoma, Endometrioid EC tissues and cells Interaction(miR-126/VEGF axis) Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay MCM3AP-AS1 was upregulated in EC and predicted poor survival. MCM3AP-AS1 directly interacted with miR-126. In addition, overexpression of MCM3AP-AS1 increased the expression levels of VEGF, a target of miR-126. MCM3AP-AS1 was upregulated in EC and predicted poor survival. Yes Moreover, overexpression of MCM3AP-AS1 and VEGF increased the migration and invasion rates of EC cells, while overexpression of miR-126 suppressed these cell behaviors. 34256796 circITCH CircRNA Homo sapiens Prostatic Neoplasms PC cell lines and tissues Regulation[HOXB13/miR-17-5p axis] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//BrdU CircITCH was significantly reduced in PC cell lines and tissues.CircITCH promoted prostate cancer progression by regulating the HOXB13/miR-17-5p axis, and circITCH have a potential usage as therapeutic target for PC tumors. Low circITCH expression level was highly related with preoperative PSA, tumor stage and Gleason score. Yes Overexpression of circITCH can inhibit the malignant phenotype of prostate cancer. 31827402 hsa_circ_102004 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Expression[highly expressed] Western Blot//qPCR//Flow Cytometry//RNA-seq//Transwell Assay In the present study, circ-102004 expression was found to be significantly higher in PCa samples than in the matched normal tissues.Circ-102004 overexpression was also accompanied by significant alterations in many signaling pathways, such as ERK, JNK, and Hedgehog, which are known to cause different types of cancers. Yes In functional experiments, circ-102004 is shown to play an oncogenic role in PCa by stimulating cancer cell migration and invasion. 30219508 NONHSAT159216.1 LncRNA Homo sapiens Behcet Syndrome Chinese Han population Interaction(miR-6778-5p) Western Blot//Transfection//Genotyping//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay Two-stage association analysis showed a significantly decreased frequency of A allele of SNP rs7130280 in BD patients compared with healthy controls [OR 0.72 (95% CI 0.64, 0.81), Pc = 1.15 × 10-6]. Functionally, SNP rs7130280 could influence the secondary structure and relative expression of NONHSAT159216.1 in human THP-1/U937 macrophages and in peripheral blood mononuclear cells from healthy volunteers. Mechanistically, rs7130280 A allele could inhibit the expression of miR-6778-5p, thus enhancing its downstream molecular RPS6KA4/IL10 in a competing endogenous RNA sponge manner. Yes In vitro, overexpression of the rs7130280 A allele also suppressed cell proliferation. 35416950 circFOXO3 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues,blood Interaction[ sponging miR-29a-3p] CCK8//qRT-PCR//Luciferase Report Assay//RNA Pull-Down In this study, we found that circFOXO3 was up-regulated in both PCa tissues and serum samples. Furthermore, we demonstrated circFOXO3 could act as miR-29a-3p sponge to up-regulate SLC25A15 expression by bioinformatics analysis, dual-luciferase reporter assays and biotinylated RNA pull-down assays. SLC25A15 could reverse the tumour suppressing roles of knock-down circFOXO3 in PCa. Of note, we found that miR-29a-3p was down-regulated; however, SLC25A15 was overexpressed in PCa samples compared with normal tissues. In conclusion, circFOXO3 acts as a miR-29a-3p sponge to exhibit oncogenic activity that affects the cell cycle and cell apoptosis in PCa through transcriptional up-regulation of SLC25A15. Our analysis suggests circFOXO3 could act as promising prostate cancer biomarkers. Yes Knock-down circFOXO3 could remarkably inhibit PCa cell cycle, proliferation and promote cell apoptosis in vitro. 31733095 hsa_circ_0001206 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues Interaction[bind to miR-1285-5p ] qRT-PCR//Microarray Three circRNAs, hsa_circ_0001206, hsa_circ_0001633, and hsa_circ_0009061 were validated to be down-regulated in PCa by quantitative real-time PCR (qRT-PCR) and hsa_circ_0001206 as well as hsa_circ_0009061 was significantly associated with clinical features of PCa patients.Dual-luciferase reporter assays showed hsa_circ_0001206 could directly bind to miR-1285-5p. The expression of Smad4, a well-known suppressive gene in PCa, can be increased by overexpression of hsa_circ_0001206 and this effect could be partly reversed by co-transfection of miR-1285-5p mimic. The study revealed expression profiles and potential functions of circRNAs and demonstrated hsa_circ_0001206 played a suppressive role in the pathogenesis of PCa. Yes Moreover, overexpression of hsa_circ_0001206 inhibited PCa cell proliferation, migration, and invasion in vitro and prevented tumor growth in vivo. 31198063 MIR100HG LncRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction( MIR100HG/hnRNPA2B1/TCF7L2 feedback loop) Bioinformatics Analysis The expression of MIR100HG was strongly correlated with EMT markers and acted as a positive regulator of EMT. hnRNPA2B1 was identified as a binding partner of MIR100HG. Mechanistically, MIR100HG maintained mRNA stability of TCF7L2, a major transcriptional coactivator of the Wnt/β-catenin signaling, by interacting with hnRNPA2B1. hnRNPA2B1 recognized the N6-methyladenosine (m6A) site of TCF7L2 mRNA in the presence of MIR100HG. TCF7L2, in turn, activated MIR100HG transcription, forming a feed forward regulatory loop. The MIR100HG/hnRNPA2B1/TCF7L2 axis was augmented in specimens from CRC patients who either developed local or distant metastasis or had disease progression that was associated with cetuximab resistance. Yes MIR100HG sustained cetuximab resistance and facilitated invasion and metastasis in CRC cells both in vitro and in vivo. 35279145 MIR100HG LncRNA Homo sapiens Urinary Bladder Neoplasms tumor tissues Interaction(miR-142-5p/CALD1) qRT-PCR//Luciferase Report Assay//Western Blot qPCR results showed that compared with the adjacent tissues, the expression of MIR100HG and CALD1 was up-regulated, and the expression of miR-142-5p was down-regulated. In addition, miR-142-5p inhibited CALD1 expression in bladder cancer cells through a direct association, and reversed the proliferation and CALD1 expression in 5,637 cells overexpressing of MIR100HG. Moreover, MIR100HG expression was positively correlated with the tumor grade and clinical grade of patients with bladder cancer. Yes Overexpression of MIR100HG effectively promoted the proliferation, migration and invasion of 5,637 cells, inhibited the expression of miR-142-5p, and induced the expression of CALD1 in 5,637 cells. 35127818 MIR100HG LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction[silencing LATS1 and LATS2] qRT-PCR At first, we measured the high expression of MIR100HG in OS tissues and cell lines by qRT-PCR.Mechanistically, MIR100HG was upregulated by the transcription factor ELK1. The upregulation of MIR100HG led to the inactivation of Hippo pathway. Furthermore, we found that MIR100HG inactivated Hippo pathway in OS cells by epigenetically silencing LATS1 and LATS2. Rescue assays demonstrated that LATS1/2 involved in MIR100HG-mediated OS progression. Yes Functionally, MIR100HG knockdown suppressed cell proliferation, cell cycle progression while promoted cell apoptosis. 30551532 circZMIZ1 CircRNA Homo sapiens Prostatic Neoplasms blood Expression[highly expressed] qRT-PCR In this study, we demonstrated that the expression of circZMIZ1 was higher in plasma of human prostate cancer than the paired benign prostatic hyperplasia (BPH) patients' plasma. Mechanistically, we also showed that circZMIZ1 could increase the expression of androgen receptor (AR) and androgen receptor splice variant 7 (AR-V7), which may be partly contributed to the occurrence and development of prostate cancer. Yes Moreover, in cultured prostate cancer cells, knockdown of circZMIZ1 inhibited cell proliferation and caused cell cycle arrest at G1. 31686520 MIR100HG LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR The results from reverse transcription-quantitative PCR demonstrated that MIR100HG expression was higher in CRC tissues compared with in corresponding normal mucosa tissues. Furthermore, the results from Kaplan-Meier analysis followed by a log-rank test revealed that patients with CRC and high MIR100HG expression exhibited poorer disease-free survival and overall survival compared with patients with CRC and lower MIR100HG expression. Yes Furthermore, results from in vitro Transwell assays and in vivo animal assays demonstrated that upregulated MIR100HG expression promoted CRC cell migration and invasion and the formation of liver metastatic colonies in mice. 31814848 MIR100HG LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissue samples and cell lines regulation[miR-5590-3p/OTX1 axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//RIP//Colony Formation Assay//Transwell Assay MIR100HG expression was upregulated, whereas that of miR-5590-3p was downregulated in TNBC. MIR100HG promotes the progression of TNBC by sponging miR-5590-3p, thereby upregulating OTX1, suggesting a new potential treatment target for TNBC. Yes Furthermore, MIR100HG knockdown could promote TNBC cell apoptosis and cell cycle arrest in G0/G1 phase while inhibiting migration, invasion and proliferation. 33088216 circZNF609 CircRNA Homo sapiens Prostatic Neoplasms PC tissues Regulation[YAP1 and AMPK signaling pathways] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Invasion Assay circZNF609 was highly expressed at PC tissues. Yes circZNF609 declined cell colony ability, viability, migration and invasion and caused apoptosis. 31387394 circHIPK3 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Regulation[regulating miRNA-338-3p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Expression level of circHIPK3 in PCa tissues was remarkably higher than that of paracancerous tissues. Overexpression of circHIPK3 promotes the proliferative and invasive potentials of PCa cells through sponging miRNA-338-3p to regulate ADAM17 expression, thus accelerating the malignant progression of PCa. Yes Knockdown of circHIPK3 inhibited the proliferative and invasive rates of PC-3 and DU145 cells. 31118688 circPDHX CircRNA Homo sapiens Prostatic Neoplasms interaction[sponging miR-378a-3p] Western Blot//FISH//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay In conclusion, our findings demonstrated that circPDHX facilitated the proliferation and invasion of PCa cells by sponging miR-378a-3p. As a result, we found that increased expression of circPDHX was associated with Gleason score (P = 0.001) and pathogenic T stage (P = 0.01) and acted as an independent prognostic factor of poor survival (P = 0.036) in patients with PCa. Yes Knockdown of circPDHX inhibited cell proliferation and invasion in vitro and in vivo, but ectopic expression of circPDHX reversed these effects. 33634097 circITGA7 CircRNA Homo sapiens Thyroid Neoplasms cell lines regulation[miR-198 ,FGFR1 ] qRT-PCR In this study, we found that circITGA7 is upregulated in TC cell lines.Mechanistically, we found that circITGA7 acts as miR-198 competitive endogenous RNA (ceRNA) to regulate FGFR1 expression. Yes Silencing of circITGA7 inhibits metastasis and proliferation of TC cell lines in vitro. 32685526 MINCR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[activating c-Myc] Flow Cytometry//qRT-PCR//MTT//Western Blot MINCR expression was increased in NSCLC patients from TCGA datasets, and was also significantly increased in our collected specimens from NSCLC patients and NSCLC cell lines. Furthermore, silencing of MINCR reduced the expression levels of oncogene c-Myc and its downstream cyclin A, cyclin D, CD4, and CDK2, as well as apoptosis-associated Bcl-2, while significantly increased the expression levels of cleaved PARP-1. In the meantime, overexpression of MINCR remarkably enhanced cell proliferation of PC9 cells and activated c-Myc and its downstream effectors. Yes Knocking down of MINCR greatly inhibited the growth of NSCLC cell lines PC9 and A549. In addition, silencing of MINCR induced cell cycle arrest and apoptosis. 31481083 circNOLC1 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues,cell lines regulation[miR-647/PAQR4 axis] RNA Pull-Down//ChIP//Migration Assay//CCK8//qRT-PCR//FISH//RNA-seq//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our research indicated that circNOLC1 was overexpressed in PCa cells and tissues, and circNOLC1 was more stable than linear NOLC1 mRNA. CircNOLC1, elevated by transcription factor NF-kappaB, promotes PCa progression via a miR-647/PAQR4 axis, and circNOLC1 is a potential biomarker and target for PCa treatment. Yes CircNOLC1 promoted PCa cells proliferation and migration in vitro and vivo. 33490086 MINCR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung tissue,cell lines Regulation[miR-126/SLC7A5 axis] qRT-PCR In the present study, results found that MINCR over expression in NSCLC tissue and cell lines was closely related to poor survival in NSCLC. In conclusion, results suggest that the MINCR-miR-126-SLC7A5 axis plays an important role in the progression of NSCLC and may serve as a potential target for lung cancer diagnosis and treatment. In the present study, results found that MINCR over expression in NSCLC tissue and cell lines was closely related to poor survival in NSCLC. Yes Functional experiments found that decreased MINCR expression inhibits NSCLC cell proliferation and migration and promotes cells apoptosis.Tumor formation assay found that knockdown of MINCR significantly inhibited tumor growth. 30528230 circHIPK3 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues Interaction[sponging miR-193a-3p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this study, we found that circHIPK3 was overexpressed in PCa tissues and that higher circHIPK3 expression was associated with tumor stage.Bioinformatics analysis and luciferase reporter assays demonstrated that circHIPK3 could promote MCL1 expression by interacting with miR-193a-3p in PCa. Finally, rescue assays illustrated that circHIPK3 knockdown could partially reverse the effects of MCL1 overexpression. Yes Moreover, circHIPK3 knockdown markedly inhibited the proliferation, migration, and invasion of PCa cells in vitro and impaired tumor growth in vivo. 30863152 MIR100HG LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Expression[highly expressed] CCK8//qRT-PCR//Invasion Assay//Migration Assay In our study, we first found levels of MIR100HG expression were increased in gastric cancer cell lines and tissue samples compared with normal gastric epithelial cell line and adjacent normal gastric mucosa tissue samples, respectively. Moreover, high MIR100HG expression was positively associated with clinical stage, tumor invasion, lymph node metastasis, and distant metastasis in gastric cancer patients. S Yes The study in vitro suggested down-regulation of MIR100HG expression inhibits cell proliferation, migration, and invasion in gastric cancer. 30886062 MINCR LncRNA Homo sapiens Colonic Neoplasms CC cells regulation[miR-708-5p-mediated Wnt/β-catenin pathway] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP MINCR was up-regulated in CC cells.MINCR sponges miR-708-5p to up-regulate CTNNB1 and activate Wnt/β-catenin pathway, thus promoting the development CC. Yes Knockdown of MINCR suppressed cell proliferation and migration. 32535381 NEAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines Regulation[NEAT1/hsa-mir-98-5p/MAPK6 axis] qRT-PCR It was observed that NEAT1 was upregulated while hsa-mir-98-5p was downregulated respectively in NSCLC cell lines compared to human normal lung epithelial BES-2B cells. Bioinformatics search was used to elucidate the correlation between NEAT1 and hsa-mir-98-5p. Additionally, a novel messenger RNA target of hsa-mir-98-5p, mitogen-activated protein kinase 6 (MAPK6), was predicted. Overexpression and knockdown studies were conducted to verify whether NEAT1 exhibits its biological functions through regulating hsa-mir-98-5p and MAPK6 in vitro. NEAT1 was able to increase MAPK6 expression and hsa-mir-98-5p mimics can inhibit MAPK6 via downregulating NEAT1 levels. We speculated that NEAT1 may act as a competing endogenous lncRNA to upregulate MAPK6 by attaching hsa-mir-98-5p in lung cancers. Taken these together, NEAT1/hsa-mir-98-5p/MAPK6 is involved in the development and progress in NSCLC. NEAT1 could be recommended as a prognostic biomarker and therapeutic indicator in NSCLC diagnosis and treatment. Yes Inhibition of NEAT1 can suppress the progression of NSCLC cells and hsa-mir-98-5p can reverse this phenomenon. 29095526 circNDST1 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC cell lines Interaction(CSNK2A1/PI3K-Akt pathway ) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qPCR//Invasion Assay//Migration Assay//CCK8//FISH//RNA-seq//Colony Formation Assay//EdU Staining//Transwell Assay CircNDST1 was highly expressed in PTC cell lines, but knocking it down inhibited the proliferation, migration, and invasive abilities of TPC1 and KTC1 cell lines. CircNDST1 bonded with CSNK2A1 and promoted the interaction between CSNK2A1 and Akt, leading to the activation of the PI3K-Akt pathway and EMT. Yes CircNDST1 was highly expressed in PTC cell lines, but knocking it down inhibited the proliferation, migration, and invasive abilities of TPC1 and KTC1 cell lines. 36306106 circTP53 CircRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues Interaction(miR-1233-3p/MDM2 axis) RNA Pull-Down//Western Blot//ISH//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//IHC CircTP53 was a circRNA highly expressed in thyroid cancer tissues. CircTP53 acted as a target of miR-1233-3p to increase MDM2 expression. Yes CircTP53 promoted cell proliferation and cell viability of TPC-1 cells. Knockdown of circTP53 inhibited the expression of Mouse double minute 2 (MDM2) and increased the protein level of p53. 32500444 hsa_circ_0000285 CircRNA Homo sapiens Thyroid Neoplasms cell lines(TPC-1, FTC133 and Nthy-ori 3-1) Interaction(microRNA-654-3p) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//RIP//qRT-PCR//MTT//Luciferase Report Assay The expression levels of circRNA_0000285 and miR-654-3p in thyroid cancer cells (TPC-1 and FTC133) were upregulated and downregulated, respectively. Yes  Functional experiments demonstrated that circRNA_0000285-siRNA decreased thyroid cancer cell proliferation, promoted cell apoptosis, enhanced Bax expression and suppressed Bcl-2 expression. All these effects were reversed following transfection with miR-654-3p inhibitor. 34345298 hsa_circ_0058124 CircRNA Homo sapiens Thyroid Neoplasms TC tissues regulation[miR-940/MAPK1 axis] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0058124 was highly expressed in TC and is a stable cyclic transcript, mainly located in the cytoplasm. Circ_0058124 might play a carcinogenic role in TC progression by regulating the miR-940/MAPK1 axis, which might provide a new idea for the treatment of TC. Yes Circ_0058124 knockdown suppressed proliferation, migration, invasion and metabolic abilities in TC cells. 32110054 MIR124-1HG LncRNA Homo sapiens Colorectal Neoplasms cancer tissues interaction[miR-1301-3p,AKT1 ] ChIP//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The data demonstrated that RNCR3 was elevated in colorectal cancer, and it was negatively correlated with expression of miR-1301-3p which was decreased in cancers.RUNX1-activated upregulation of RNCR3 promoted colorectal cancer progression by sponging miR-1301-3p to elevate AKT1 levels in vitro and in vivo. Yes Knockdown of RNCR3 or miR-1301-3p overexpression significantly inhibited cell growth, invasion, and increased apoptosis through suppressing expression of Cyclin A1, PCNA, N-cadherin, Bcl-2, and promoting expression of E-cadherin, Bax in vitro and in vivo. 32239427 MIR124-1HG LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[Akt/GSK3 β Signaling Pathway] qRT-PCR//Western Blot RNCR3 was highly expressed in both HCC tissues and cells, and the expression of RNCR3 was closely related to tumor size, tumor number, TNM stage, and overall survival time. In terms of mechanism, RNCR3 induced the phosphorylation of Akt (thr308 and ser473) and GSK3β (ser9) but decreased the expression of GSK3β, which activated the Akt/GSK3β signaling pathway. RNCR3 was highly expressed in both HCC tissues and cells, and the expression of RNCR3 was closely related to tumor size, tumor number, TNM stage, and overall survival time. Yes In vitro, RNCR3 served as an oncogene to promote cell proliferation, migration, and invasion, and in vivo, RNCR3 promoted the growth and metastasis of HCC tumors. 33062024 hsa_circ_0102272 CircRNA Homo sapiens Thyroid Neoplasms TC tissues Expression[highly expressed] qRT-PCR//MTT//RNA-seq//Transwell Assay Both sequencing and quantitative reverse transcriptse-polymersase chain reaction analysis corroborated that hsa_circ_0102272 was dramatically elevated in TC tissues and cell lines compared to the control group. Patients with high expression of hsa_circ_0102272 showed significantly short overall survival and progression-free survival compared to those patients with hsa_circ_0102272 low expression. Yes In vitro experiments confirmed that knockdown of hsa_circ_0102272 could restrain cell proliferation, migration and invasion, as well as facilitate apoptosis of TC cells in vitro. 32367651 NEAT1 LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues Expression[highly expressed] qRT-PCR NEAT1 is highly expressed in lung adenocarcinoma tissues and promotes lung cancer cell proliferation and migration. Yes NEAT1 is highly expressed in lung adenocarcinoma tissues and promotes lung cancer cell proliferation and migration. 29788922 hsa_circ_0010957 CircRNA Homo sapiens Lupus Erythematosus, Systemic CD4+ T cells Interaction(microRNA‑125b) qRT-PCR//ELISA//Luciferase Report Assay//Western Blot CD4+ T cells in patients with SLE expressed higher levels of hsa_circ_0010957 compared with healthy individuals and was a good differentiator of the active from inactive SLE disease. It was also determined that hsa_circ_0010957 mediated microRNA (miR)‑125b/STAT3 signaling and subsequent secretion of inflammatory cytokines interleukin (IL)‑18, IL‑6 and IL‑17, which are important factors in the process of SLE. Hsa_circ_0010957 abrogated the proinflammatory effect of IL‑6 via the blockade of STAT3 signaling. CD4 T cells in patients with SLE expressed higher levels of hsa_circ_0010957 compared with healthy individuals and was a good differentiator of the active from inactive SLE disease Yes It was also determined that hsa_circ_0010957 mediated microRNA (miR)‑125b/STAT3 signaling and subsequent secretion of inflammatory cytokines interleukin (IL)‑18, IL‑6 and IL‑17, which are important factors in the process of SLE. Hsa_circ_0010957 abrogated the proinflammatory effect of IL‑6 via the blockade of STAT3 signaling. 33880592 hsa_circ_0044516 CircRNA Homo sapiens Prostatic Neoplasms blood,cell lines Expression[lower expressed] qRT-PCR Circ_0044516 was verified to be significantly upregulated in the exosomes from prostate cancer patients and the cell lines.By bioinformatics and luciferase reporter assays, circ_0044516 was verified to downregulate miR-29a-3p expression and negatively related to miR-29a-3p expression levels in prostate cancer. In a summary, the study indicated that circ_0044516 played an important role in prostate cancer cell survival and metastasis, which suggested that an oncogenic role of circ_0044516 in prostate cancer. Yes Further investigation demonstrated that circ_0044516 downregulation inhibited the proliferation and metastasis of prostate cancer cells. 31625175 circRACGAP1 CircRNA Homo sapiens Lupus Erythematosus, Systemic SLE tissues and cell line Interaction(miR-22-3p/ PTEN/AKT signalling) qRT-PCR//Luciferase Report Assay//RNA-seq//Western Blot Down-regulated circRACGAP1 was observed and correlated with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score, anti-double-stranded (ds) DNA, and complement C3 level in patients with SLE. Mechanistic investigation revealed that circRACGAP1 could serve as a sponge of miR-22-3p to regulate PTEN/AKT signalling. Down-regulated circRACGAP1 was observed and correlated with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score, anti-double-stranded (ds) DNA, and complement C3 level in patients with SLE. Yes Overexpression of circRACGAP1 significantly alleviated cell apoptosis in Jurkat cells within UVB exposure. 35543435 circTUBGCP3 CircRNA Homo sapiens Rectal Neoplasms rectal cancer tissues and cell lines Interaction(miR-375) In Vivo Experiment//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircTUBGCP3 was significantly up-regulated in rectal cancer tissues and cell lines. CircTUBGCP3 negative regulated microRNA-375 (miR-375) expression through interacting with it and circTUBGCP3 silencing-mediated effects in rectal cancer cells were largely based on the up-regulation of miR-375. Yes CircTUBGCP3 interference inhibited the colony formation ability, migration, invasion, cell cycle progression, and glycolysis and promoted the apoptosis in rectal cancer cells. 34515875 hsa_circ_0058129 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(miR-873-5p/follistatin-like 1 axis) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay// In Vivo Experiment//Cell Proliferation Assay//IHC//Transwell Assay The circ_0058129 and FSTL1 abundances were increased, while the miR-873-5p content was decreased in PTC tissues and cells compared with control groups. Moreover, miR-873-5p repressed PTC cell malignancy by binding to FSTL1. Circ_0058129 targeted miR-873-5p to regulate FSTL1. Yes Circ_0058129 shortage inhibited PTC cell proliferation, migration, and invasion. 35373391 MIR124-1HG LncRNA Homo sapiens Glioma glioma tissues Interaction[Akt/GSK-3β pathway] qRT-PCR In the present study, it was revealed that the expression of RNCR3 was increased in glioma tissues compared with in corresponding adjacent normal tissues. Finally, the results of western blot analyses revealed that knockdown of RNCR3 led to a decrease in the expression levels of phosphorylated Akt and glycogen synthase kinase-3β (GSK-3β), without any clear effect on the expression levels of total Akt and GSK-3β. Collectively, these results suggested that RNCR3 is able to regulate cell proliferation, the cell cycle and cell invasion in glioma, potentially via the Akt/GSK-3β signaling pathway. Furthermore, increased levels of RNCR3 expression were associated with tumor progression and poor survival rates of patients with glioma. Yes In addition, the U87 and U251 cell lines were selected to investigate the biological function and potential mechanisms of RNCR3 in glioma, and it was observed that RNCR3 knockdown led to an impairment of the proliferative and invasive abilities of cells; furthermore, G1 phase arrest was induced in glioma cells in vitro. 31788110 MIR124-1HG LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues interaction[miR-185-5p] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//cell invasion assay//Colony Formation Assay Here, our results confirmed that the RNCR3 expression was increased in prostate cancer compared to the corresponding adjacent normal prostate tissues.Finally, we further confirmed that RNCR3 binds to miR-185-5p, which has been identified as a tumor suppressor in some human cancers, including prostate cancer. Moreover, our data showed that the increased expression of RNCR3 is significantly associated with tumor progression and poor survival of prostate cancer patients. Yes Additionally, we found that RNCR3 knockdown could suppress the ability of proliferation, colony formation, and invasion of prostate cancer cells. 29887969 circGLCE CircRNA Homo sapiens Intervertebral Disc Degeneration nucleus pulposus tissue interaction[targeting of miR-587/STAP1] Flow Cytometry//qRT-PCR//FISH CircGLCE was found to stably exist in the cytoplasm of nucleus pulposus (NP) cells. It was downregulated in IDD.Thus, CircGLCE attenuates IDD by inhibiting the apoptosis of NP cells and ECM degradation through the targeting of miR-587/STAP1. Yes Knockdown of CircGLCE promoted apoptosis and induced the expression of matrix-degrading enzymes in NP cells. 33159017 hsa_circ_0005276 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues Interaction[FUS] ChIP//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Microarray//Transwell Assay The Expression[Expression[up-expression]-expression]regulation of XIAP and circ0005276 was determined in PCa tissues and cell lines.Mechanistically, we verified that circ0005276 interacted with FUS binding protein (FUS) so as to activate the transcription of XIAP. Yes It was observed from CCK-8 and EdU assays, cell proliferation was efficiently sExpression[Expression[up-expression]-expression]pressed by the knockExpression[down-expression] of XIAP or circ0005276 (Fig. 3a, b). Moreover, we detected cell apoptosis in two PCa cells after silencing of circ0005276 or XIAP. It was uncovered that caspase-3 activity and Bcl-2 protein level were increased, while the protein level of Bax was reduced 31624242 circABCC4 CircRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues, cell lines( PC3 and DU145) Interaction[miR-1182,FOXP4] qRT-PCR//Luciferase Report Assay//Western Blot We found that circABCC4 was remarkably Expression[Expression[up-expression]-expression]-regulated in prostate cancer tissues and cell lines and promoted FOXP4 expression by sponging miR-1182 in prostate cancer cells. Yes CircABCC4 knockExpression[down-expression] markedly sExpression[Expression[up-expression]-expression]pressed prostate cancer cell proliferation, cell-cycle progression, migration and invasion in vitro. Furthermore, silencing of the circRNA also delayed tumor growth in vivo. 31270953 hsa_circ_0000144 CircRNA Homo sapiens Thyroid Neoplasms TC tissues and TC cell lines regulation[miR-217/AKT3 pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//BrdU//Transwell Assay Circ_0000144 expression was remarkably elevated in TC tissues (p < 0.001) and TC cell lines. Circ_0000144 exerts a cancer-promoting effect on TC cells via the miR-217/AKT3 pathway. The elevation of circ_0000144 expression was markedly linked to tumor size (p = 0.015), TNM stage (p = 0.025) and lymph node metastasis (p = 0.017) of the patients. Yes Functional studies showed that knocking down circ_0000144 repressed the malignancy of TC cells. 32890417 NEAT1 LncRNA Homo sapiens Cholangiocarcinoma CCA cell lines Interaction(EZH2/E-cadherin ) In Vivo Experiment//Western Blot//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay NEAT1 levels were also higher in CCA cell lines than in a normal biliary epithelium cell line (HIBEpic). RIP and ChIP assays suggest that NEAT1 is recruited to the E-cadherin promoter by EZH2 (enhancer of zeste homolog 2), where it represses E-cadherin expression. Yes NEAT1 knockdown in CCA cell lines using shNEAT1 reduced cell proliferation and colony formation in CCK-8 and colony formation assays, respectively. CCA cells transfected with shNEAT1 also exhibited reduced metastasis and invasiveness in Transwell assays. NEAT1 knockdown cells produced smaller tumors, demonstrating that NEAT1 promotes tumor growth in vivo. Silencing of NEAT1 increased E-cadherin expression in vitro, and E-cadherin expression was inversely correlated with NEAT1 expression in CCA tissue samples. 28810932 MBNL1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patient tissues and NSCLC cells interaction[sponging miR-135a-5p] Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//EdU Staining//Transwell Assay In our research, we confirmed that MBNL1-AS1 was significantly reduced in NSCLC patient tissues and NSCLC cells.To sum up, our data revealed the significance of the MBNL1-AS1 and miR-135a-5p in NSCLC. In conclusion, MBNL1-AS1 could be a new therapeutic target to treat NSCLC. Yes Meanwhile, we reported that overexpression of MBNL1-AS1 obviously repressed A549 and H1975 cell proliferation, blocked cell cycle and inhibited the migration and invasion. 32092823 hsa_circ_0090231 CircRNA Homo sapiens Atherosclerosis HAECs Interaction(miR-635/NLRP3 axis) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay The treatment of HAECs with ox-LDL not only led to significant increase in the levels of circ_0090231 but also resulted in improved cell viability as well as reduced cell injury and pyroptosis as compared to that in non-treated cells. The circ_0090231 was also identified to function as a sponge for miR-635, knockdown of which reverses the effects of circ_0090231 inhibition. Furthermore, our results revealed that levels of NLRP3, a miR-635 target, are not only augmented in the AS model but its overexpression also weakens the miR-635 regulatory effects in the AS development. Yes The treatment of HAECs with ox-LDL not only led to significant increase in the levels of circ_0090231 but also resulted in improved cell viability as well as reduced cell injury and pyroptosis as compared to that in non-treated cells. 34637670 circCRKL CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells regulation[miR-141/KLF5 axis] RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay CircCRKL and KLF5 were decreased, and miR-141 was increased in PCa tissues and cells.These findings revealed that circCRKL inhibited the progression of PCa through upregulating KLF5 expression by sponging miR-141, elucidating a novel regulatory pathway in PCa cells. Yes The functional analysis discovered that the overexpression of circCRKL repressed cell cycle progression, migration, invasion, and boosted apoptosis of PCa cells. 32919302 circDDX17 CircRNA Homo sapiens Prostatic Neoplasms Prostate Cancer tissues regulation[circDDX17/miR-346/LHPP pathway] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP Furthermore, circDDX17 expression was downregulated significantly in PCa. Overall, our findings indicated that the circDDX17/miR-346/LHPP pathway inhibited the progression of prostate cancer and that circDDX17 may be a new potential therapeutic or diagnostic target for treating and diagnosing prostate cancer. Yes These results suggested that circDDX17 suppressed PC cell mobility, proliferation, and invasion. 32904557 circGRN CircRNA Homo sapiens Atherosclerosis HVSMCs Interaction(miR-214-3p/FOXO1 Axis) Western Blot//Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay//ELISA//Colony Formation Assay//Transwell Assay In this study, we found that circ_GRN was elevated in the serum of AS and oxidized low-density lipoprotein (ox-LDL)-induced HVSMCs. The in vitro AS model was established by exposing HVSMCs to ox-LDL, and we found circ_GRN knockdown reversed ox-LDL-evoked cell proliferation, migration, and inflammation. In a mechanical study, miR-214-3p directly bound to circ_GRN or FOXO1, and circ_GRN could regulate FOXO1 expression by competitively binding to miR-214-3p. Importantly, we demonstrated that miR-214-3p inhibition attenuated the protective effects of circ_GRN knockdown on ox-LDL-induced HVSMCs; besides that, miR-214-3p overexpression abolished ox-LDL-triggered HVSMC proliferation, migration, and inflammation, which were counteracted by FOXO1 upregulation. In conclusion, circ_GRN promoted the proliferation, migration, and inflammation of HVSMCs through miR-214-3p/FOXO1 axis in ox-LDL-induced AS model in vitro, suggesting the potential involvement in an AS process, which provided a potential candidate for future clinic intervention in AS. Yes Importantly, we demonstrated that miR-214-3p inhibition attenuated the protective effects of circ_GRN knockdown on ox-LDL-induced HVSMCs; besides that, miR-214-3p overexpression abolished ox-LDL-triggered HVSMC proliferation, migration, and inflammation, which were counteracted by FOXO1 upregulation. 33818550 MILIP LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells interaction[targeting miR-3196/OTX1 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay MAFG-AS1 was highly expressed in HCC tissues and cells. MAFG-AS1 facilitated the progression of HCC via targeting miR-3196/OTX1 axis, which might be used as a new insight for HCC treatment. Yes Attenuation of MAFG-AS1 evidently suppressed the proliferation, migration, invasion and tumor angiogenesis of HCC cells, suggesting that MAFG-AS1 played an oncogenic role in HCC. 33336731 circSCAP CircRNA Homo sapiens Atherosclerosis patients with AS and THP-1 cells Interaction(miR-221-5p/PDE3B axis) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay CircSCAP and phosphodiesterase 3B (PDE3B) levels were elevated, whereas the miR-221-5p level was decreased in patients with AS and oxidized low-density lipoprotein (ox-LDL)-induced THP-1 cells.In conclusion, circSCAP facilitated lipid accumulation, inflammation, and oxidative stress in ox-LDL-induced THP-1 macrophages by regulating miR-221-5p/PDE3B axis. Yes CircSCAP absence suppressed lipid deposition, inflammation, and oxidative stress in ox-LDL-induced THP-1 cells. 34321402 circMBOAT2 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines regulation[miR-1271-5p/mTOR axis] qRT-PCR//RNA Pull-Down//Western Blot Herein, we identified a novel circRNA, termed circMBOAT2 (has_circ_0007334), which was significantly overexpressed in PCa tissues and cell lines.circMBOAT2 promotes proliferation and metastasis of PCa through miR-1271-5p/mTOR axis-mediated activation of the PI3K/Akt pathway. Overexpression of circMBOAT2 was associated with high Gleason score, advanced pathological T stage, and poor prognosis. Yes Overexpression of circMBOAT2 promoted proliferation, migration, and invasion of PCa cells in vitro, and enhanced tumorigenesis and metastasis in vivo. 32645691 MILIP LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-339-5p/NFKB1-mediated IGF1) Transwell Assay//Wound Healing Assay//qRT-PCR//FISH//RIP//Colony Formation Assay//ChIP Our data showed significantly high expression pattern of MAFG-AS1 in the OC tissues and cells. Further mechanistic investigations revealed that MAFG-AS1 upregulated the IGF1 expression pattern through recruitment of NFKB1, whereas MAFG-AS1 upregulated the NFKB1 expression pattern through binding to miR-339-5p. Yes Thus, MAFG-AS1 overexpression accelerated the EMT, invasion, and migration of OC cells, which could be annulled by silencing of IGF1 or NFKB1. Besides, our in vitro findings were successfully recapitulated in the xenograft mice. 34035482 MILIP LncRNA Homo sapiens Urinary Bladder Neoplasms BLCA tissues and cells regulation[miR-143-3p/COX-2 Axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay MAFG-AS1 was remarkably upregulated in BLCA patient tissues and cell lines,The MAFG-AS1/miR-143-3p/COX-2 axis contributes to BLCA progression. MAFG-AS1 was remarkably upregulated in BLCA patient tissues and cell lines, and its high expression was closely related to histological grade, tumor size, and lymph node metastasis. Yes Silencing of MAFG-AS1 inhibited BLCA cell proliferation, metastasis, and invasion, while overexpression of MAFG-AS1 in BLCA cells had opposite biological effects. 33238264 circHIPK3 CircRNA Homo sapiens Prostatic Neoplasms PCa cells tissues interaction[ Sponging miR-338-3p] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay CircHIPK3 expression was upregulated in PCa cells and prostate cancer tissues. CircHIPK3 promotes G2/M transition and induces PCa cell proliferation by sponging miR-338-3p and increasing the expression of Cdc25B and Cdc2. Yes Overexpression of circHIPK3 or circHIPK3 silencing altered PCa viability, proliferation and apoptosis in vitro. 32547085 hsa_circ_0016068 CircRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues and cell lines regulation[miR-330-3p/BMI-1 Axis] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Microarray//Colony Formation Assay//EdU Staining//Transwell Assay We identified circ-0016068, a circRNA that was expressed more strongly in prostate cancer tumors vs. normal paired tissue, and confirmed its relatively high expression in prostate cancer tissues and cell lines. In so doing, circ-0016068 sequesters miR-330-3p and frees BMI-1 to enhance the proliferation, migration, and invasion of prostate cancer cells, and the metastasis of xenograft tumors. Yes We also discerned that circ-0016068 promotes the epithelial-to-mesenchymal transition (EMT) and the growth, migration, and invasion of prostate cancer cells in vitro; and promotes the growth and metastasis of tumors in a mouse model of prostate cancer. 32984325 circFMN2 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines regulation[LHX2] qRT-PCR Finally, we found that circFMN2 acts as a competing endogenous RNA (ceRNA) for miR-1238 to regulate LIM-homeobox gene 2 (LHX2) expression. circFMN2 regulates the miR-1238/LHX2 axis to promote PCa progression. Yes Function assays revealed that knockdown of circFMN2 significantly reduced PCa cell growth in vitro and in vivo. 32526477 NEAT1 LncRNA Homo sapiens Alzheimer Disease cell lines Interaction[Targeting miR-107] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT NEAT1 expression was enhanced in Aβ-treated SH-SY5Y and SK-N-SH cells .NEAT1 was indicated as a decoy of miR-107. miR-107 abundance was reduced in Aβ-treated cells, and its overexpression reversed Aβ-induced injury. Moreover, interference of miR-107 abated silencing of NEAT1-mediated inhibition of neuronal damage in Aβ-treated SH-SY5Y and SK-N-SH cells. Yes NEAT1 expression was enhanced in Aβ-treated SH-SY5Y and SK-N-SH cells, and its knockdown attenuated Aβ-induced inhibition of viability and promotion of apoptosis and p-Tau levels. 31250578 MILIP LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues Interaction(miR-125b-5p/SphK1 axis) qRT-PCR//Wound Healing Assay We found that MAFG-AS1 was significantly up-regulated in BC tissues and predicted a poor survival rate. MAFG-AS1 interacted with miR-125b-5p. Interestingly, we found that SphK1, a downstream target of miR-125b-5p, was negatively correlated with miR-125b-5p, while it was positively correlated with MAFG-AS1 across BC tissues. In addition, overexpression of MAFG‑AS1 upregulated the expression of SphK1 in BC cells, and attenuated the inhibitory effects of miR-125b-5p on the expression of SphK1. We found that MAFG-AS1 was significantly up-regulated in BC tissues and predicted a poor survival rate. Yes Functional assays showed that overexpression of MAFG?AS1 promoted BC cell proliferation, migration, and invasion, while its effects were attenuated by overexpression of miR-125b-5p. Moreover, overexpression of miR-125b-5p inhibited BC cell proliferation, migration, and invasion, while its effects were alleviated by overexpression of SphK1. 33400245 MILIP LncRNA Homo sapiens Leukemia, Myeloid, Acute AML cells and in serum and bone narrow from AML Interaction(miR-147b/HOXA9) qRT-PCR//Luciferase Report Assay We noted that MAFG-AS1 was overexpressed in AML cells and in serum and bone narrow from AML compared with normal controls specimen. These data illustrated that MAFG-AS1 acted as one oncogenic gene and accelerated AML progression via modulating miR-147b/HOXA9 axis. Yes Elevated expression of MAFG-AS1 increased cell growth, cycle and EMT in AML cell HL-60 cell. 36229729 MILIP LncRNA Homo sapiens Glioblastoma GBM tissues Interaction(miR-34a) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay MAFG-AS1 was upregulated in GBM, while mature miR-34a was downregulated in GBM.Interestingly, MAFG-AS1 was inversely correlated with mature miR-34a but not miR-34a precursor across GBM tissues. In GBM tissues, the overexpression of MAFG-AS1 did not affect the expression levels of miR-34a precursor but reduced the expression levels of mature miR-34a. Yes MAFG-AS1 promoted the expression of DICER and Drosha in GBM cells. Moreover, the overexpression of MAFG-AS1 promoted the proliferation of GBM cells and reduced the inhibitory effects of miR-34a on cell proliferation but did not affect cell cycle, apoptosis and migration. The overexpression of MAFG-AS1 promoted the progression of GBM in vivo by promoting the proliferation of GBM cells while miR-34a reversed the effect of overexpression of MAFG-AS1. 33911899 MILIP LncRNA Homo sapiens Adenocarcinoma of Lung Regulation[ MAFG-AS1/miR-744-5p/MAFG axis] CCK8//FISH//EdU Staining//Western Blot Based on the data of GEPIA database, lncRNA MAFG-AS1 was upregulated in LUAD tissues, which was associated with poor prognosis of patients. In summary, this study unveiled the MAFG-AS1/miR-744-5p/MAFG axis in LUAD, providing a potent and promising therapeutic target for LUAD patients. Based on the data of GEPIA database, lncRNA MAFG-AS1 was upregulated in LUAD tissues, which was associated with poor prognosis of patients. Yes The results indicated that silencing of MAFG-AS1 suppressed cell proliferation but induced cell apoptosis. 31211984 MILIP LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction(miR-3196/SOX12 pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//FISH//Colony Formation Assay//EdU Staining//Transwell Assay We observed augmented expression of MAFG-AS1 in LUAD tissues compared with normal adjacent tissues, and its association with poor prognosis.Besides, MAFG-AS1 also targeted miR-3196 directly by acting as an endogenous sponge, thereby rescuing the inhibition of SOX12, a target of miR-3196. Thus, the rescue assays demonstrated that MAFG-AS1 promotes cell migration, invasion, and EMT by modulating the miR-3196/SOX12 pathway. We observed augmented expression of MAFG-AS1 in LUAD tissues compared with normal adjacent tissues, and its association with poor prognosis. Yes Furthermore, MAFG-AS1 overexpression promoted LUAD cell migration, proliferation, invasion, and epithelial mesenchymal transition (EMT). 35275356 NEAT1 LncRNA Homo sapiens Alzheimer Disease SH-SY5Y cells Interaction( micro-27a-3p) RNA Pull-Down//qPCR//Luciferase Report Assay//Western Blot After being induced by amyloid protein, lncRNA NEAT1 was up-regulated while micro-27a-3p was down-regulated in SH-SY5Y cells. Yes Down-regulation of lncRNA NEAT1 or up-regulation of micro-27a-3p could reduce cell apoptosis, increase cell activity, down-regulate amyloid protein, BACE1 protein, APP protein, Tau protein and its phosphorylation, and up-regulate caspase 3 protein and its lysate protein. 34540002 MILIP LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[miR-149-3p,HOXB8] qRT-PCR//Luciferase Report Assay//RIP LncRNA MAFG-AS1 and HOXB8 were found to be highly expressed in CRC tissues and cells, while miR-149-3p was under-expressed.Taken together, lncRNA MAFG-AS1 downregulation inhibits the malignant behaviors of CRC cells by upregulating miR-149-3p and downregulating HOXB8, providing a potential therapeutic target for CRC treatment. Yes In addition, lncRNA MAFG-AS1 silencing by shRNA or miR-149-3p upregulation by mimic suppressed the migration, proliferation, invasion and tumorigenesis but promoted the apoptosis of HCT116 and LoVo cells. 33093810 hsa_circ_0050486 CircRNA Homo sapiens Atherosclerosis THP-1 macrophages Interaction(miR-1270 ) Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//ELISA We identified nine upregulated circRNAs and found that circ_0050486 was significantly upregulated in a THP-1 + PMA + oxLDL group compared with a THP-1 + PMA group. . Furthermore, circ_0050486 targeted and inhibited miR-145 and miR-1270. Upregulated miR-1270 markedly inhibited IL-6 and TNF-α levels and the cell death rates in oxLDL-induced THP-1 macrophages. Yes Additionally, circ_0050486 knockdown markedly inhibited IL-6 and TNF-α concentrations and the cell death rates in oxLDL-induced THP-1 macrophages. 36111016 MINCR LncRNA Homo sapiens Osteoarthritis OA cartilage tissues, chondrocytes Interaction(miR-146a-5p/BMPR2 ) RNA Pull-Down//Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Viability Assay//IHC//IF Here, MINCR and BMPR2 were downregulated whereas miR-146a-5p was upregulated in OA cartilage tissues compared with control as well as IL-1β-induced chondrocytes compared with normal chondrocytes. We also proved the binding relationship between MINCR and miR-146a-5p, and the BMPR2 acted as a target of miR-146a-5p. Mechanism analysis using rescue experiments in vitro and in vivo, MINCR silencing reversed the effects of miR-146a-5p downregulation in OA. Overexpression of miR-146a-5p also reversed the function of BMPR2 overexpression in OA. Yes Function experiments indicated that MINCR upregulation promoted cell proliferation and inhibited apoptosis and extracellular matrix (ECM)-degeneration. 35848848 MILIP LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cell lines Expression[highly expressed] qRT-PCR We found gastric cancer tissues and cell lines had remarkably increased MAFG-AS1 expression in comparison to normal gastric mucosa tissues and normal human gastric epithelial cell line, and high MAFG-AS1 expression was positively associated with diffuse type, advanced clinical stage, extensive depth of invasion, more lymph node metastasis, and present distant metastasis in gastric cancer patients. We found gastric cancer tissues and cell lines had remarkably increased MAFG-AS1 expression in comparison to normal gastric mucosa tissues and normal human gastric epithelial cell line, and high MAFG-AS1 expression was positively associated with diffuse type, advanced clinical stage, extensive depth of invasion, more lymph node metastasis, and present distant metastasis in gastric cancer patients. Yes The loss-of-function study showed knocking down MAFG-AS1 expression inhibited gastric cancer cell proliferation, migration and invasion in vitro. 32079456 circGOLPH3 CircRNA Homo sapiens Prostatic Neoplasms interaction[bind to the CBX7] RNA Pull-Down//Tunel//CCK8//qRT-PCR//Flow Cytometry//RIP//MTT//EdU Staining CircGOLPH3 could bind to the CBX7 protein that was highly expressed in the PC-3 cell. Additionally, a functional test on CBX7 showed that the CBX7 overexpression notably improved the proliferative capacity and the viability of PC-3 cells and decreased cellular apoptosis, which was consistent with the effects of circGOLPH3. Yes The results showed that after overexpression of circGOLPH3, the proliferative capacity and the viability of PC-3cells were significantly improved, whereas apoptosis was inhibited. 33245100 circSLC19A1 CircRNA Homo sapiens Prostatic Neoplasms PCa tissue and cell regulation[miR-326/MAPK1 Axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircSLC19A1 expression was up-regulated in PCa tissue and cell cytoplasm.CircSLC19A1 silencing inhibited PCa cell proliferation, migration and invasion through regulating miR-326/MAPK1 axis. Yes Silencing circSLC19A1 inhibited PCa cell viability, proliferation, migration, invasion and miR-326 expression. 33239918 hsa_circ_0067934 CircRNA Homo sapiens Thyroid Neoplasms TC tissues and cells Regulation[miR-1304/CXCR1 axis] CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay Circ_0067934 and CXCR1 were enhanced and miR-1304 decreased in TC tissues and cells. Notably, circ_0067934 regulated CXCR1 expression via sponging miR-1304 in TC cells. Both miR-1304 silencing and CXCR1 elevation reversed the facilitation of apoptosis and the retardation of proliferation, migration, and invasion induced by circ_0067934 reduction in TC cells. Yes Circ_0067934 downregulation triggered apoptosis and curbed proliferation, migration, and invasion of TC cells in vitro, as well as repressed tumor growth in vivo. 31858554 MINCR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Interaction[Wnt/β-catenin signals] qRT-PCR At first, the expression level of MINCR in OSCC tissues and cell lines as well as corresponding normal controls was evaluated by qRT-PCR assay. The relative high level of MINCR was observed in OSCC tissues and cell lines. Importantly, the effect of MINCR knockdown on Wnt/β-catenin signaling pathway was detected by luciferase reporter and western blot assays. It was found that MINCR knockdown obviously decreased the activity of Wnt/β-catenin pathway. Rescue assays were further used to validate the role of Wnt/β-catenin pathway in MINCR-mediated OSCC progression. The effects of MINCR knockdown on OSCC cell proliferation and migration were partly reversed by the activator of Wnt/β-catenin pathway (LiCl). The overall survival rate of OSCC patients with high or low level of MINCR was analyzed by using Kaplan-Meier method. Yes In addition, functional assay revealed that MINCR knockdown significantly suppressed OSCC cell proliferation and invasion. 30777615 MINCR LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Regulation( Wnt/β-catenin signal) In Vivo Experiment The osteosarcoma tissues and cell lines were found to exhibit significant (P<0.05) over-expression of lncRNA-MINCR.Western blot analysis revealed that lncRNA-MINCR operated through Wnt/β-catenin signaling pathway to control the growth and metastasis of osteosarcoma cells. Yes Silencing of lncRNA-MINCR in osteosarcoma cells suppressed their cell viability through the induction of apoptosis. The Saos-2 osteosarcoma cells exhibited significant (P<0.05) decline in migration and invasion rate together with inhibition of EMT under transcriptional knockdown of lncRNA-MINCR.In vivo mice tumorigenesis was significantly (P<0.05) restricted under lncRNA-MINCR repression. 35767742 MINCR LncRNA Homo sapiens Glioma cell lines regulation[miR-876-5p/GSPT1 Axis] RNA Pull-Down//qRT-PCR//RIP//FISH//Luciferase Report Assay MINCR was up-regulated in glioma.MINCR shared the binding sites with the 3'-untranslated region of GSPT1 and prevented the binding of miR-876-5p to GSPT1 mRNA, thus up-regulating the level of GSPT1. Yes MINCR depletion markedly refrained glioma cell proliferation, migration and invasion via sponging miR-876-5p. 32333234 MIR4713HG LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OTSCC tissues Interaction( let‑7c‑5p) In Vivo Experiment//IHC//Western Blot//Transfection//Wound Healing Assay//Migration Assay//qRT-PCR//RNA-seq//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//EdU Staining//Transwell Assay The present study performed a series of experiments to investigate the impact of MIR4713HG on OTSCC and revealed that upregulation of MIR4713HG had a crucial role in promoting cell proliferation and metastasis of OTSCC cell lines both in vitro and in vivo. In conclusion, the present study demonstrated that lncRNA MIR4713HG acted as a pro‑tumor factor facilitating cell proliferation and metastasis of OTSCC via affecting the let‑7c‑5p/TMC7 signaling pathway, which presents as a promising therapeutic target in OTSCC. Yes The present study performed a series of experiments to investigate the impact of MIR4713HG on OTSCC and revealed that upregulation of MIR4713HG had a crucial role in promoting cell proliferation and metastasis of OTSCC cell lines both in vitro and in vivo. 33760127 MINCR LncRNA Homo sapiens Liver Neoplasms HCC tissues,cell lines regulation[microRNA-107/β-catenin] CCK8//qRT-PCR qPCR results showed that the level of MINCR in HCC was remarkably higher than that in adjacent tissues, and the difference was statistically significant. Moreover, MINCR was capable of promoting the proliferation and inhibiting apoptosis of liver cancer cells via regulating microRNA-107/β-catenin. Compared with patients with low level of MINCR, patients with high level of MINCR had lower overall survival rate. Yes Similarly, the cell proliferation ability of sh-MINCR group was remarkably decreased while the apoptosis ability was oppositely increased when compared with the short hairpin RNA (shRNA) group. 32521894 MILIP LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells regulation[MAFG-AS1/miR-150-5p/MYB axis] qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Western Blot The results demonstrated that the expression levels of MAFG?AS1 were significantly upregulated in breast cancer tissues and cells compared with those in normal breast tissues and cells. In conclusion, the results of the present study demonstrated that MAFG‑AS1 functioned as a novel oncogenic lncRNA in the development of human breast cancer via regulating the miR‑150‑5p/MYB axis, which suggested that MAFG‑AS1 may be a novel biomarker for the diagnosis and prognosis of human breast cancer. Yes High MAFG?AS1 expression promoted the proliferation, migration and epithelial?mesenchymal transition of breast cancer cells. 33367930 MILIP LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[miR-147b/NDUFA4] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Firstly, we found that the expression of MAFG-AS1 was upregulated in CRC tissues and positively correlated with the advanced tumor stage. Taken together, our study suggested that MAFG-AS1 functions as a novel oncogenic lncRNA in the development of CRC by regulating miR-147b/NDUFA4. Firstly, we found that the expression of MAFG-AS1 was upregulated in CRC tissues and positively correlated with the advanced tumor stage. Yes Furthermore, overexpression of MAFG-AS1 promoted cell proliferation, cell cycle progression, and invasion, and inhibited apoptosis, while transduction of miR-147b partially reversed the effect of MAFG-AS1 on cellular processes. 30348529 MILIP LncRNA Homo sapiens Breast Neoplasms tumor tissues and cells regulation[JAK2/STAT3 signaling pathway,MAFG-AS1/miR-3196/TFAP2A regulatory axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay MAFG-AS1 was highly expressed in tumor tissues and cells.MAFG-AS1 knockdown attenuated breast cancer progression in vitro and in vivo through activation of the JAK2/STAT3 signaling pathway by the MAFG-AS1/miR-3196/TFAP2A regulatory axis. Yes MAFG-AS1 knockdown restrained proliferation, colony formation, and glycolysis but promoted apoptosis of breast cancer cells. Moreover, MAFG-AS1 knockdown reduced tumor growth in vivo. 33165437 MILIP LncRNA Homo sapiens Breast Neoplasms breast cancer cells Interaction(miR-574-5p/SOD2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Here we showed that downregulation of MAFG-AS1 inhibited the viability, migration, and invasion of BC cells.Mechanism investigation showed that inhibition of MAFG-AS1 induced apoptosis via the intrinsic apoptotic pathway and overexpression of Bcl-2 could inhibited it. Further, MAFG-AS1 acts as a sponge of miR-574-5p which directly binds to SOD2 mRNA. Yes Here we showed that downregulation of MAFG-AS1 inhibited the viability, migration, and invasion of BC cells. 33989902 hsa_circ_0062020 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay Circ_0062020 and TRIP13 were upregulated, while miR-615-5p was downregulated in PCa tissues and cells. Yes Circ_0062020 knockdown or miR-615-5p overexpression inhibited the proliferation and metastasis, and promoted apoptosis, which could be reversed by miR-615-5p inhibitor or pc-TRIP13 in ionizing radiation (IR)-treated PCa cells. 33235500 circIRAK1 CircRNA Homo sapiens Atherosclerosis AS serums and HUVECs Interaction(miR-330-5p/TRIM14 ) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay The expression of circIRAK1 was upregulated in AS serums and ox-LDL-treated HUVECs.CircIRAK1 served as a molecular sponge for miR-330-5p. CircIRAK1 regulated ox-LDL-mediated cell injury by absorbing miR-330-5p. In addition, miR-330-5p prevented endothelial cell dysfunction caused by ox-LDL via targeting tripartite motif containing 14 (TRIM14). TRIM14 expression was upregulated by circIRAK1 through sponging miR-330-5p. Yes Silencing circIRAK1 enhanced cell viability and angiogenesis while suppressed cell apoptosis, inflammatory response and oxidative stress in ox-LDL-stimulated HUVECs. 36336926 MILIP LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell line Interaction(miR-3612 and FKBP4) RNA Pull-Down//CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU//ELISA MAFG-AS1 and FKBP4 were both up-regulated in breast cancer tissues. Meanwhile, MAFG-AS1 could sponge miR-3612 to elevate the expression of FKBP4. Besides, FKBP4 could activate the cell proliferation and inhibit cell apoptosis and autophagy, which could relieve the inhibitory effect of miR-3612 on breast cancer cells. Yes MAFG-AS1 could function as an oncogene in breast cancer to activate cell proliferation, and inhibit cell apoptosis and autophagy. 35653827 MIR497HG LncRNA Homo sapiens Colorectal Neoplasms CRC cells and samples Interaction(miR-3918/ ACTG2 axis) qRT-PCR//Western Blot//Colony Formation Assay//Transwell Assay MIR497HG was markedly downregulated in CRC cells and samples. Overexpression of MIR497HG decreased miR-3918 expression while increased ACTG2 expression. MIR497HGexerts inhibitory effects on CRC progression by the miR-3918/ACTG2 axis.Our study conducted a systematic analysis of the biological roles of ACTG2, miR-3918 and MIR497HG, and the relationship among them in CRC progression. ACTG2 and MIR497HG were found to be tumour suppressors in CRC cell growth. More importantly, a novel ceRNA network, with MIR497HG as a ceRNA to regulate the miR-3918/ACTG2 axis, was found to play a key role in CRC cell proliferation, migration and invasion. Yes Further, the inhibitory effects exerted by MIR497HG overexpression on malignant phenotypes of CRC cells were reversed by ACTG2 knockdown. 35652208 hsa_circ_0088233 CircRNA Homo sapiens Prostatic Neoplasms rostate cancer tissues interaction[Targeting hsa-miR-185-3p] qRT-PCR//Microarray By screening a circRNA microarray assay, we found that circ_0088233 was upregulated in prostate cancer tissues compared to adjacent normal tissues, and this upregulation can be verified in 46 pairs of prostate cancer and adjacent normal tissues examined using quantitative reverse transcription-PCR. In conclusion, circ_0088233 may function as an oncogene and play an oncogenic role by sponging hsa-miR-185-3p. The level of circ_0088233 correlated with the TNM stage. Yes Knockdown of circ_0088233 reduced cell proliferation, migration, invasion, and induced G1 phase arrest and apoptosis. 33195183 MILIP LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines regulation[miR-765/PDX1 Axis] RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Transwell Assay MAFG-AS1 was significantly up-modulated in ESCC tissues and cell lines.Our research indicates that the MAFG-AS1/miR-765/PDX1 axis accelerates ESCC cell proliferation, migration, invasion and aerobic glycolysis. Yes MAFG-AS1 significantly accelerated ESCC cell proliferation, migration, invasion and aerobic glycolysis. 32801913 MIR137HG LncRNA Homo sapiens Stomach Neoplasms GC patients Interaction(miR-2682-3p /FUS) Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//IP//IHC//Transwell Assay Data showed that MIR137HG expressed significantly higher in GC than in SM. MIR137HG is distributed in both the nucleus and cytoplasm. It was co-located with FUS and could directly interact with FUS, which might interact with other proteins, such as MET(MET-proto-oncogene, receptor tyrosine kinase), RHOC(ras homolog family member), and CTNNB1(catenin beta1).These proteins may involve different signaling pathways to regulate gastric cancer progression. By contrast, the embedded miR-2682-3p could antagonize the series functions of its host lncRNA-MIR137HG by targeting FUS. Yes MIR137HG promoted colony formation and migration in vitro and promoted tumor formation and metastasis in vivo. 35733138 Mir155hg LncRNA Rattus norvegicus Colorectal Neoplasms CRC tissues/cells Interaction(miR-650/ANXA2 axis) RNA Pull-Down//CCK8//qRT-PCR//FISH//Colony Formation Assay MIR155HG and ANXA2 were highly expressed in CRC tissues/cells and of prognostic values for CRC patients. MIR155HG competed with ANXA2 for binding miR-650 and can also directly target ANXA2. MIR155HG and ANXA2 were highly expressed in CRC tissues/cells and of prognostic values for CRC patients. Yes Knockdown of MIR155HG or ANXA2 suppressed M2 macrophage polarization, and proliferation, migration, invasion and oxaliplatin resistance of CRC cells. 34562123 MIR155HG LncRNA Homo sapiens Melanoma melanoma cell lines and tissues Interaction( MiR-485-3p/PSIP1 Axis) In Vivo Experiment//Transwell Assay//Bioinformatics Analysis//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//EdU Staining//ChIP Herein, we found that MIR155HG was markedly upregulated in melanoma cell lines and tissues. We further determined that the SP1 transcription factor was responsible for driving MIR155HG upregulation in melanoma. By using predictive bioinformatics analyses, we identified miR-485-3p as a microRNA (miRNA) capable of binding to both MIR155HG and the 3' UTR of PSIP1. Elevated MIR155HG levels were linked to decreased overall survival (OS) in melanoma patients, and we further determined that MIR155HG expression was an independent predictor of melanoma patient prognosis. Yes When MIR155HG was knocked down in melanoma cells, this impaired their proliferative, migratory, and invasive activity. 34225636 MIR17HG LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissue Interaction[miR-17-5p] RIP//qRT-PCR//ChIP Here, we identified an immune-related lncRNA, MIR17HG, whose expression was gradually upregulated in adjacent, adenoma, and colorectal cancer tissue.Mechanistically, MIR17HG increased the expression of NF-κB/RELA by competitively sponging the microRNA miR-375. In addition, RELA transcriptionally activated MIR17HG in a positive feedback loop by directly binding to its promoter region. Moreover, miR-17-5p, one of the transcribed miRNAs from MIR17HG, reduced the expression of the tumor suppressor B-cell linker (BLNK), resulting in increased migration and invasion of colorectal cancer cells. MIR17HG also upregulated PD-L1, indicating its potential role in immunotherapy. Yes MIR17HG promoted tumorigenesis and metastasis in colorectal cancer cells both in vitro and in vivo. 31409641 circRTN1 CircRNA Homo sapiens Thyroid Neoplasms TC tissues and cells Interaction(miR-431-5p/TGFA) IHC//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of circRTN1 was increased in TC tissues and cells. MiR-431-5p was a target of circRTN1, and miR-431-5p downregulation reversed the role of circRTN1 knockdown in TC cells. TGFA was identified as a direct target of miR-431-5p, and miR-431-5p exerted the anti-tumor role in TC cells by downregulating TGFA.Moreover, circRTN1 sponged miR-431-5p to regulate TGFA expression. Yes Knockdown of circRTN1 suppressed TC cell proliferation, migration, and invasion, and increased cell apoptosis. Furthermore, circRTN1 knockdown inhibited tumor growth in vivo. 35804263 hsa_circ_0003611 CircRNA Homo sapiens Alzheimer Disease AD patients andSK-N-SH cells Interaction( miR-885-5p/KREMEN1) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//ELISA Circ_0003611 was overexpressed in AD patients and Aβ-treated SK-N-SH cells. MiR-885-5p was validated as a miRNA target of circ_0003611. The protective function of circ_0003611 downregulation was achieved by releasing miR-885-5p in Aβ-treated SK-N-SH cells. KREMEN1 was a downstream gene of miR-885-5p. Overexpression of miR-885-5p attenuated the Aβ-triggered cell injury by reducing the KREMEN1 expression. KREMEN1 was regulated by circ_0003611 via sponging miR-885-5p in Aβ-treated SK-N-SH cells. Yes Aβ-induced apoptotic, inflammatory and oxidative damages were relieved after knockdown of circ_0003611. 35076819 circAXL CircRNA Homo sapiens Alzheimer Disease SK-N-SH cells Interaction(miR-1306-5p/PDE4A ) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA CircAXL was overexpressed in Aβ1-42-treated SK-N-SH cells. MiR-1306-5p was screened as a target of circAXL, and miR-1306-5p inhibition abolished the effects of circAXL knockdown. MiR-1306-5p inhibited the expression of PDE4A, and circAXL regulated PDE4A expression by targeting miR-1306-5p. MiR-1306-5p restoration also alleviated Aβ1-42-induced cell injuries, while PDE4A reintroduction abolished the effects of miR-1306-5p restoration. Exosomal circAXL and exosomal miR-1306-5p had diagnostic values for AD. Yes CircAXL knockdown alleviated Aβ1-42-induced cell cytotoxicity, cell apoptosis, inflammation, oxidative stress and endoplasmic reticulum (ER) stress in SK-N-SH cells.CircAXL knockdown alleviates Aβ1-42-induced neurotoxicity in AD pathology via repressing PDE4A by releasing miR-1306-5p. 35229272 NEAT1 LncRNA Homo sapiens Glioma glioma tissues interaction[SOX2,miR-132] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay NEAT1 was up-regulated in glioma. NEAT1 promoted glioma development by promoting SOX2 expression through suppressing miR-132. Yes Knockdown of NEAT1 inhibited glioma cells' viability, migration and invasion. 30053878 hsa_circ_0057209 CircRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues and cells Interaction(MicroRNA-183/STK4) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//IF//IHC//Transwell Assay Initial results revealed that circRNA_0057209 and STK4 were both reduced, while miR-183 was up-regulated in thyroid cancer tissues and cells. Experiments including RNA pull-down and RIP assays further identified that upregulation of circRNA_0057209 augmented the expression of STK4, a target gene of miR-183, by competitively-binding to miR-183. Yes Furthermore, functional experiments provided evidence that overexpression of circRNA_0057209 not only inhibited the proliferative, migratory, and invasive properties of thyroid cancer cells while facilitating their apoptosis but also delayed tumor growth. Conversely, upregulation of miR-183 or silencing of STK4 reversed the changes induced by circRNA_0057209. 35308166 MIR200CHG LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(miR-200c/141-3p/YB-1 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//cell invasion assay//IP//Colony Formation Assay We found that MIR200CHG is highly expressed in breast cancer tissues and is related to the tumor size and histopathological grade. MIR200CHG directly binds to the transcription factor Y-box binding protein-1 (YB-1), and inhibits its ubiquitination and degradation. MIR200CHG regulates YB-1 phosphorylation at serine 102, thereby affecting the expression of genes related to tumor cell proliferation, apoptosis, invasion, and drug resistance. Additionally, MIR200CHG partially affects the expression of miR-200c/141-3p encoded by its intron region. We found that MIR200CHG is highly expressed in breast cancer tissues and is related to the tumor size and histopathological grade. Yes In vitro and in vivo experiments confirmed that MIR200CHG can promote breast cancer proliferation, invasion, and drug resistance. 34272387 circCCDC66 CircRNA Homo sapiens Thyroid Neoplasms TC tissues and cell lines Interaction(miR-211-5p/PDK4 axis) Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay The results demonstrated that circCCDC66 expression was significantly increased in TC tissues and cell lines. Further validation demonstrated that circCCDC66 directly interacted with the microRNA (miR) miR-211-5p. Subsequently, the activity of circCCDC66 was attenuated by miR-211-5p. In addition, the results demonstrated that circCCDC66 may promote papillary thyroid cancer progression by sponging miR-211-5p and increasing expression of PDK4. Yes Furthermore, silencing circCCDC66 inhibited TC cell proliferation, migratory and invasive abilities and glycolysis in vitro. 33841577 MIR194-2HG LncRNA Homo sapiens Liver Neoplasms liver cancer tissues and cell lines regulation[miR-1207-5p/TCF19/Wnt/β-Catenin Signaling] Western Blot//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay MIR194-2HG was upregulated in liver cancer tissues and cell lines. MIR194-2HG acts in an oncogenic role and activates the Wnt/β-catenin signaling pathway via a miR-1207-5p/TCF19 axis-mediated mechanism, which provides a novel avenue for diagnostic or therapeutic interventions in liver cancer. Liver cancer patients with higher expression of MIR194-2HG revealed poor overall survival compared with those who had lower expression of MIR194-2HG. Yes MIR194-2HG promoted the proliferation, migration, and invasion of HepG2 and Huh7 cells by acting as a ceRNA mechanism for the miR-1207-5p/TCF19 axis to activate the Wnt/β-catenin signaling pathway. 33116574 MIR17HG LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-138-5p/p38/Elk-1 signaling pathway) qRT-PCR//Western Blot In the present study, the expression of the glycolysis-related lncRNA MIR17HG gradually increased from adjacent normal to CRC to the paired liver metastatic tissues, and high MIR17HG expression predicted poor survival, especially in patients with liver metastasis. Mechanistically, MIR17HG functioned as a ceRNA to regulate HK1 expression by sponging miR-138-5p, resulting in glycolysis in CRC cells and leading to their invasion and liver metastasis. More interestingly, lactate accumulated via glycolysis activated the p38/Elk-1 signaling pathway to promote the transcriptional expression of MIR17HG in CRC cells, forming a positive feedback loop, which eventually resulted in persistent glycolysis and the invasion and liver metastasis of CRC cells. In the present study, the expression of the glycolysis-related lncRNA MIR17HG gradually increased from adjacent normal to CRC to the paired liver metastatic tissues, and high MIR17HG expression predicted poor survival, especially in patients with liver metastasis. Yes Functionally, MIR17HG promoted glycolysis in CRC cells and enhanced their invasion and liver metastasis in vitro and in vivo. 34145399 MIR205HG LncRNA Homo sapiens Myocardial Reperfusion Injury EAC and cell line Interaction(Hh) In Vivo Experiment//qRT-PCR//RNA-seq//Cell Proliferation Assay//Cell Cycle Assay These experiments revealed that miR205HG was downregulated in EAC vs. normal esophageal epithelia (NE) as well as in EAC cell lines.Finally, we show that one mechanism of action of miR205HG involves the Hh signaling pathway: miR205HG and Hh expression levels were inversely correlated in both EAC (r = -0.73) and BE (r = -0.83) tissues, and in vitro studies revealed details of Hh signaling inhibition induced by miR205HG. Yes its forced overexpression inhibited EAC cell proliferation and cell cycle progression in vitro. Similarly, overexpression of miR205HG inhibited xenograft tumor growth in mice In vivo. 33916875 MIR17HG LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Regulation[ Wnt/β-catenin signaling] CCK8//qRT-PCR//Western Blot Expression of MIR17HG was found to be elevated in colon cancer (P<0.001). Expression[up-expression]regulation of MIR17HG was significantly correlated with lymph node metastasis (P=0.005) and TNM stage (P<0.001), and also an independent prognostic indicator of overall survival and disease-free survival in colon cancer patients. Yes SExpression[up-expression]pression of MIR17HG inhibited colon cancer cell viability, invasion, and EMT process, and significantly reduced the ability of the cells to form tumors in vivo. 35116852 MIR17HG LncRNA Homo sapiens Parkinson Disease PD patients, mouse models and cells. Interaction(miR-153-3p and SNCA) qRT-PCR//IHC//Western Blot MIR17HG was up-regulated while miR-153-3p was down-regulated in PD patients, mouse models and cells. MIR17HG's function was enforced by sponging miR-153-3p and releasing the attenuation of the putative targets of miR-153-3p and SNCA. Yes Inhibiting MIR17HG attenuated neuronal apoptosis, microglial activation and SNCA expression in PD mice. Conditioned medium from 6-OHDA-treated SH-SY5Y cells intensified microglial inflammation, while inhibition of MIR17HG or overexpression of miR-153-3p restrained the inflammatory responses. 35137671 MIR17HG LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[FXR1/MIR17HG/miR-346(miR-425-5p)/TAL1/DEC1 axis] ChIP//Western Blot//Flow Cytometry//qRT-PCR//RIP//CCK8//Transwell Assay FXR1and MIR17HG were upregulated in glioma tissues and cell lines.FXR1/MIR17HG/miR-346(miR-425-5p)/TAL1/DEC1 axis plays a novel role in regulating the malignant behavior of glioma cells, which may be a new potential therapeutic strategy for glioma therapy. Yes Downregulation of FXR1 or MIR17HG resulted in inhibition of glioma cells progression.Remarkably, FXR1 knockdown combined with inhibition of MIR17HG resulted in the smallest tumor volumes and the longest survivals of nude mice in vivo. 30691465 NEAT1 LncRNA Homo sapiens Glioma cell line Regulation[NEAT1/miR-107/CDK14 axis] qRT-PCR Here, we found that NEAT1 was greatly upregulated in glioma cells compared with normal human astrocytes (NHAs).Subsequently, bioinformatics analysis was performed to predict the correlation between NEAT1 and miR-107. Moreover, it was revealed that NEAT1 could modulate miR-107 via serving as an endogenous sponge of miR-107. The direct binding correlation between NEAT1 and miR-107 was validated in our study. In addition, cyclin dependent kinase 14 (CDK14) was predicted as an messenger RNA target of miR-107 and the association between them was confirmed in our research. Moreover, we implied that NEAT1 demonstrated its biological functions via regulating miR-107 and CDK14 in vivo. In summary, our findings indicated that NEAT1/miR-107/CDK14 axis participated in glioma development. NEAT1 could act as a significant prognostic biomarker in glioma progression. Yes Then, we observed that knockdown of NEAT1 suppressed the growth and invasion of glioma cells including U251 and SW1783 cells. Reversely, overexpression of NEAT1 dramatically induced glioma cell survival, increased cell colony formation, and promoted cell invasion ability. 30480816 circPVT1 CircRNA Homo sapiens Thyroid Neoplasms MTC tissues and cells Interaction(miR-455-5p/CXCL12/CXCR4 signaling pathway) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Migration Assay//RIP//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//H&E Staining//Cell Cycle Assay//Colony Formation Assay//Invasion Assay//Transwell Assay miR-455-5p was reduced in MTC tissues and cells while circPVT1 was elevated. miR-455-5p targeted CXCL12 while circPVT1 sponged miR-455-5p. Knockdown of CXCL12 or CXCL12/CXCR4 signaling inhibitor reversed the effects of circPVT1 overexpression or miR-455-5p inhibitor on EMT and MTC cell proliferation, migration and invasion. Their levels were correlated with prognosis of MTC. Yes Overexpression of miR-455-5p or sh-circPVT1 suppressed EMT and MTC cell proliferation, migration and invasion. Knockdown of circPVT1 or miR-455-5p overexpression repressed MTC tumor growth and lung metastasis in vivo. 33962657 NEAT1 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-185-5p/DNMT1/mTOR signaling] qRT-PCR In this study, we first demonstrated that NEAT1 expression was upregulated, and miR-185-5p downregulated in glioma tissues and cells. In conclusion, these results suggest that NEAT1 promotes glioma tumorigenesis via miR-185-5p/DNMT1/mTOR signaling, which may provide a new target for the diagnosis and therapy of glioma. Yes In vitro and in vivo experiments verified that NEAT1 was a competing endogenous RNA for miR-185-5p for promoting DNA methyltransferase 1 (DNMT1) expression and activated mammalian target of rapamycin (mTOR) signaling, thus inhibiting apoptosis, and promoting glioma migration, proliferation, and epithelial-mesenchymal transition process. 32803763 NEAT1 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-152-3p/CCT6A pathway] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Transwell Assay The levels of NEAT1, CCT6A were highly expressed, but miR-152-3p was decreased in glioma tissues and cells. NEAT1 enhanced glioma progression, partially through miR-152-3p/CCT6A pathway. T Yes NEAT1 depletion or miR-152-3p mimics suppressed cell viability, migrated and invaded abilities but induced apoptotic rate in A172 and U251 cells, while the introduction of CCT6A partly counteracted these impacts. In addition, NEAT1 silencing impeded xenograft tumor growth in vivo. 32454145 NEAT1 LncRNA Homo sapiens Glioma glioma tissues regulation[MiR-92b] RNA Pull-Down//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay The expression of NEAT1 was low in glioma tissues and cells compared to the normal ones. Importantly, the tumor suppressor function of overexpressing NEAT1 was achieved by downregulating miR-92b and subsequently upregulating DKK3. Yes Overexpression of NEAT1 inhibited proliferation and promoted apoptosis of glioma cell lines (U-87 MG and U251). 31933377 NEAT1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction(miR‑377/FGFR1 axis) Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay//Transwell Assay The results revealed that the expression levels of NEAT1 and FGFR1 were significantly elevated, whereas miR‑377 expression was markedly decreased in CC tissues and cell lines.In conclusion, suppression of NEAT1 inhibited cell viability and migration, and promoted apoptosis of CC cells, and these effects were achieved through regulation of the miR‑377/FGFR1 axis. Yes In HeLa and C33A cells, after NEAT1 knockdown, miR?377 expression was increased, cell viability and migration were inhibited, and apoptosis was induced. Similarly, silencing FGFR1 inhibited cell viability and migration, and induced apoptosis of HeLa and C33A cells. 34779493 circTIAM1 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC cells and tissues Interaction(miR-646/HNRNPA1 signaling pathway) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay circTIAM1 was then selected because of its increased expression in PTC and association with apoptosis, proliferation, and migration of PTC cells in vitro and in vivo. Mechanistically, circTIAM1 acted as a sponge of microRNA-646 and functioned in PTC by targeting miR-646 and heterogeneous ribonucleoprotein A1. Yes circTIAM1 was then selected because of its increased expression in PTC and association with apoptosis, proliferation, and migration of PTC cells in vitro and in vivo. 35022405 NEAT1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines regulation[ELF3 ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay In this study, our findings showed that NEAT1 expression was upregulated in PC tissues and cell lines; high NEAT1 expression was associated with tumor size, TNM stage, lymph node and distant metastasis, and also predicted poor prognosis. In this study, our findings showed that NEAT1 expression was upregulated in PC tissues and cell lines; high NEAT1 expression was associated with tumor size, TNM stage, lymph node and distant metastasis, and also predicted poor prognosis. Yes Functional experiments demonstrated that NEAT1 could promote PC cell proliferation and metastasis both in vitro and in vivo. 32064164 NEAT1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Interaction[sponging miR-9-5p] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay In this study, we found that the lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) is significantly increased in both cervical cancer tissues and cell lines. Molecular studies uncovered that NEAT1 functions as competitive endogenous RNA (ceRNA), binding the micro-RNA miR-9-5p and suppressing its expression. However, we consistently found that when NEAT1 was highly expressed, it attenuated the inhibitory effect of miR-9-5p on the expression of PTEN and POU2F1, which are the targets of miR-9-5p. Consistent with the negative regulation of NEAT1 on miR-9-5p, restoration of miR-9-5p inhibited the growth-promoting effects of NEAT1 on cervical cancer cells. Taken together, these results indicated that NEAT1 plays an important role in the regulation cervical cancer cell growth by targeting miR-9-5p. Our findings characterized the possible mechanism of NEAT1 in cervical cancer. Yes Overexpression of NEAT1 promoted the proliferation and migration of cervical cancer cells. 30096244 hsa_circ_0003611 CircRNA Homo sapiens Alzheimer Disease AD patients and SH-SY5Y and SK-N-SH cells Interaction(miR-383-5p/KIF1B axis) Western Blot//RIP//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay In this work, the abundance of circ_0003611 was augmented in AD patients and SH-SY5Y and SK-N-SH cells treated with Aβ. Circ_0003611 worked as a miR-383-5p sponge, and the protective role of circ_0003611 absence on Aβ-triggered neuronal injury was overturned by releasing miR-383-5p. Meanwhile, miR-383-5p directly targeted KIF1B, and miR-383-5p upregulation might relieve Aβ-triggered neuronal injury by reducing KIF1B expression. Mechanical analysis discovered that circ_0003611 served as a sponge of miR-383-5p to impact KIF1B expression. These findings indicated that circ_0003611 improved Aβ-triggered neuronal injury in AD through targeting the miR-383-5p/KIF1B axis, which might deliver innovative therapy targeting for AD. Yes Aβ-mediated cell proliferation, apoptosis, inflammatory response, oxidative stress, and glycolysis were abolished through circ_0003611 silencing. 35960460 MIR205HG LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cell lines regulation[miR-214/SOX4 Axis] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Here, we found MIR205HG was substantially up-regulated in ESCC, and there was a positive correlation between MIR205HG expression and tumor size and lymphatic metastasis of ESCC patients. Here, we found MIR205HG was substantially up-regulated in ESCC, and there was a positive correlation between MIR205HG expression and tumor size and lymphatic metastasis of ESCC patients. Yes Inhibition of MIR205HG attenuated cell proliferation, migration, and invasion. Silencing MIR205HG increased G1 phase cell counts and decreased S phase cell counts, along with increased apoptotic cell populations. 33376358 NONHSAT024276 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(PTBP1) qRT-PCR The downregulation of NONHSAT024276 closely correlated with larger tumor volume and higher aspartate transaminase levels. Mechanistically, NONHSAT024276 directly bound to polypyrimidine tract-binding protein 1 (PTBP1), downregulating it and forming a feedback loop. Furthermore, NONHSAT024276 increased the ratio of M1 and M2 isoforms of pyruvate kinase (PKM1/PKM2) and also obstructed the PTBP1/PKM-mediated glycolysis. Finally, the rescue assays confirmed that NONHSAT024276 functioned in HCC via downregulating PTBP1 to increase the PKM1/PKM2 ratio. Hence, this study supported a model in which NONHSAT024276 downregulated PTBP1 and formed a feedback loop to increase the PKM1/PKM2 ratio to inhibit glycolysis and progression of HCC, opening new prospects for preventing or treating HCC. The downregulation of NONHSAT024276 closely correlated with larger tumor volume and higher aspartate transaminase levels. Yes Functional experiments were performed to verify the role of NONHSAT024276 in HCC progression, and the negative effects of NONHSAT024276 expression on cell proliferation and migration were identified. 36529521 MIR205HG LncRNA Homo sapiens Osteosarcoma human OS tissues Interaction(microRNA 2114-3p (miR-2114-3p)/twist family bHLH transcription factor 2 (TWIST2) axis) qRT-PCR//Western Blot//IF In this study, we found that MIR205 host gene (MIR205HG) was significantly elevated in human OS tissues, especially in metastatic OS tissues. The vast majority of MIR205HG was situated in the cytosol, and served as a competing endogenous RNA (ceRNA) that directly bound to microRNA 2114-3p (miR-2114-3p), resulting in increased twist family bHLH transcription factor 2 (TWIST2) level. Functionally, the attenuated cell invasion caused by MIR205HG knockdown was effectively rescued by miR-2114-3p silencing or TWIST2 overexpression. Pre-clinically, high MIR205HG was linked with dismal overall and relapse-free survival. Yes Stable knockdown of MIR205HG inhibited OS cell invasion and lung metastatic foci formation, but did not affect cell viability. 33949284 NONHSAT024778 LncRNA Homo sapiens Chordoma chordoma tissues Interaction(miR-1290/Robo1 axis) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis An increased NONHSAT024778 expression was correlated with a decreased miR-1290 level in chordoma tissues. Bioinformatics analysis showed that NONHSAT024778 acted as ceRNA to regulate Robo1 via sponging miR-1290 in chordoma cells, thereby promoting chordoma cell malignant progression. In vivo results confirmed the anti-tumor effects of NONHSAT024778 knockdown activating miR-1290 to inhibit the oncogene Robo1 Yes NONHSAT024778 knockdown suppressed the proliferation and invasion of chordoma cells. miR-1290 restored expression rescued the carcinogenic function of NONHSAT024778. 33767589 NONHSAT028712 LncRNA Homo sapiens Breast Neoplasms breast cancer cell lines and tissues Expression[highly expressed] Western Blot//qRT-PCR//FISH//Cell Viability Assay//Microarray In this study, we identified one lncRNA, lncRNA NONHSAT028712 (Lnc712), was highly expressed in breast cancer cell lines and tissues based on microarray screening. Yes Knockdown of Lnc712 largely inhibited breast cancer cell proliferation. 31892853 MIR205HG LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Interaction[sponging miR-122-5p] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay Conclusively, we found that MIR205HG was upregulated in cervical cancer tissues supported by GEPIA database and in cell lines through qRT-PCR, and its depletion inhibited the proliferation and metastasis of CC cells.Furthermore, MIR205HG could sponge miR-16-5p to accelerate malignant progression of CC cells via upregulating FOXP2. Yes Conclusively, we found that MIR205HG was upregulated in cervical cancer tissues supported by GEPIA database and in cell lines through qRT-PCR, and its depletion inhibited the proliferation and metastasis of CC cells. 31023531 NEAT1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues and cells Interaction(NEAT1/miR-101/DNA-PKcs axis) CCK8//qRT-PCR//Western Blot DNA-PKcs expression was significantly elevated in human PDAC tissues and cells. DNA-PKcs overexpression was correlated with TNM stage and lymph node metastasis. Higher expression of DNA-PKcs was closely correlated with patients of worse overall survival (OS). DNA-PKcs knockdown suppresses malignant behaviors of PDAC cells. Further study showed that miRNA-101 level was decreased in PDAC tissues and cells, which could be responsible for DNA-PKcs overexpression and DNA-PKcs mediated oncogenic actions in PDAC cells. Moreover, NEAT1 functions as an oncogene influencing cell proliferation, migration and invasion in part by serving as a competing endogenous RNA (ceRNAs) modulating miR-101 expression, leading to up-regulation of DNA-PKcs. Higher expression of DNA-PKcs was closely correlated with patients of worse overall survival (OS). Yes DNA-PKcs knockdown suppresses malignant behaviors of PDAC cells. Further study showed that miRNA-101 level was decreased in PDAC tissues and cells, which could be responsible for DNA-PKcs overexpression and DNA-PKcs mediated oncogenic actions in PDAC cells. 34405022 hsa_circ_102171 CircRNA Homo sapiens Thyroid Cancer, Papillary tumor tissues and cell lines Regulation[Wnt/β-catenin pathway] RNA Pull-Down//CCK8//qRT-PCR//RIP//Colony Formation Assay//EdU Staining//Transwell Assay CircRNA_102171 expression was upregulated in tumor tissues and cell lines.CircRNA_102171 overexpression promotes PTC progression through activating Wnt/β-catenin pathway in a CTNNBIP1-dependent way. Yes CircRNA_102171 silencing suppressed PTC cell proliferation, migration and invasion while promoting apoptosis. CircRNA_102171 knockdown inhibited PTC growth in vivo. 30424816 MIR205HG LncRNA Homo sapiens Melanoma melanoma tissues Interaction(miR-299-3p/VEGFA axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Invasion Assay//Transwell Assay Similarly, MIR205HG levels were significantly higher melanoma tissues than adjacent normal skin tissues (n=30). Dual luciferase reporter and RNA pull-down assays confirmed that MIR205HG directly binds to microRNA (miR)-299-3p. Targetscan analysis and dual luciferase reporter assays showed that miR-299-3p directly binds to the 3'UTR of VEGFA mRNA. Yes CCK-8 and flow cytometry assays showed that MIR205HG knockdown significantly decreased the viability of melanoma cells. 33535182 NEAT1 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Regulation[ NEAT1/miR-133a/SOX4 axis] qRT-PCR NEAT1 level in several cervical cancer cells was quantified and we found NEAT1 was greatly upregulated in vitro. In addition, in vivo assays were conducted to prove the role of NEAT1/miR-133a/SOX4 axis in cervical cancer. These findings implied that NEAT1 served as a competing endogenous RNA to sponge miR-133a and regulate SOX4 in cervical cancer pathogenesis. To sum up, it was implied that NEAT1/miR-133a/SOX4 axis was involved in cervical cancer development. Yes NEAT1 knockdown inhibited cervical cancer development through repressing cell proliferation, colony formation, capacity of migration, and invasion and also inducing the apoptosis. 30932200 MIR205HG LncRNA Homo sapiens esophageal carcinoma ESCA tumors Interaction(HNRNPA0/LIN28A) RNA Pull-Down//Wound Healing Assay//Immunoblotting//qPCR//MTT//Bioinformatics Analysis//Transwell Assay In this study, by using real-time quantitative PCR, we found that the expression of the miR205 host gene (miR205HG; a lncRNA) was downregulated in ESCA tumors when compared with normal esophageal tissues or adjacent normal tissues of tumors. In relation to the mechanism, our data show that miR205HG interacts with heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0) mRNA and then hamper its translation by interacting with lin-28 homolog A (LIN28A). Yes Furthermore, we demonstrated that miR205HG modulates the expression of extracellular matrix-related genes in ESCA cells. In the transwell assay, downregulation of miR205HG contributes to migration and invasion of ESCA cells 34821009 NEAT1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells regulation[ miR-124/NF-κB Pathway] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The expression of lncRNA-NEAT1 was upregulated in CC tissues and cells and positively correlated with TNM stage and lymph node metastasis. LncRNA-NEAT1 promoted the migration and invasion of CC cells via regulating miR-124/NF-κB pathway. The expression of lncRNA-NEAT1 was upregulated in CC tissues and cells and positively correlated with TNM stage and lymph node metastasis. Yes Overexpression of lncRNA-NEAT1 promoted the proliferation, migration and invasion, influenced the expression of EMT markers, and activated NF-κB pathway in HeLa and SiHa cells. 32368085 MIR205HG LncRNA Homo sapiens lung squamous cell carcinoma LUSC tissues and cell lines regulation[miR-299-3p/MAP3K2 axis] Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression levels of MIR205HG in LUSC tissues and cell lines were obviously up-regulated. MIR205HG acts as a competing endogenous RNA (ceRNA) to expedite cell proliferation and progression via targeting miR-299-3p in LUSC. Yes Down-regulation of MIR205HG expression remarkably reduced cell proliferation, migration and epithelial-to-mesenchymal transition (EMT) progression, whereas promoted cell apoptosis. 32513149 circPTPRM CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines Interaction(miR-885-5p/DNMT3A axis) Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay CircPTPRM was overexpressed in PTC tissues and cell lines, which predicted poor prognosis. It was subsequently confirmed that circPTPRM competed with miR-885-5p for DNMT3A binding. CircPTPRM promoted PTC progression via miR-885-5p/DNMT3A signal axis. CircPTPRM was overexpressed in PTC tissues and cell lines, which predicted poor prognosis. Yes CircPTPRM inhibition significantly alleviated the proliferation, migration, and invasion abilities. 36098040 hsa_circ_0000285 CircRNA Homo sapiens Thyroid Neoplasms THCA specimens and cells Interaction(miR-127-5p/CDH2) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay As opposed to normal samples and cells, hsa_circ_0000285 level was overtly increased in THCA specimens and cells. Notably, we demonstrated that hsa_circ_0000285 might target miR-127-5p/CDH2 axis in THCA. Afterward, our findings manifested that miR-127-5p attenuation blocked the function of hsa_circ_0000285 depletion in THCA cells. In the final step, CDH2 was proven to mediate the repressive potency of miR-127-5p in the malignant behaviors of THCA. Mechanistically, hsa_circ_0000285 induced the development of THCA via functioning as a competing endogenous RNA (ceRNA) of miR-127-5p to enhance CDH2 expression, which provided a new perspective for THCA therapy. Yes The downregulation of hsa_circ_0000285 weakened the proliferative and migratory capacity of THCA cells and promoted cell apoptosis. In addition, hsa_circ_0000285 silence suppressed the tumor growth of xenograft model mice in vivo. 35447001 MIR205HG LncRNA Homo sapiens Hepatoblastoma HB tissues and cells Interaction(miR-514a-5p/MAPK/ PI3K/AKT) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay MIR205HG was significantly overexpressed in HB. Furthermore, MIR205HG competitively bound to microRNA-514a-5p (miR-514a-5p) and targeted mitogen-activated protein kinase 9 (MAPK9) to stimulate mitogen activated protein kinase (MAPK) signaling pathway. Besides, MIR205HG also served as a sponge for microRNA-205-5p (miR-205-5p) to activate the PI3K/AKT signaling pathway. Yes Moreover, MIR205HG inhibition suppressed the proliferative, migratory and invasive capacities of HB cells. 34996511 hsa_circ_0058063 CircRNA Homo sapiens Thyroid Neoplasms TC tissues and cells Interaction(miR-330-3p/SDC4 axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//migration assay//Cell Proliferation Assay Circ_0058063 was upregulated in TC tissues and cells, but miR-330-3p expression showed an opposite trend. In addition, circ_0058063 is able to target miR-330-3p that is also able to target syndecan 4 (SDC4). circ_0058063 can act as a carcinogen in cases with TC via the miR-330-3p/SDC4 axis. Yes Both silencing circ_0058063 and upregulating miR-330-3p can suppress the proliferation and migration of TC cells, upregulate Bax, and downregulate Bcl-2. 35324533 NEAT1 LncRNA Homo sapiens Glioma glioma tissues Interaction(miR-98-5p/BZW1) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay We demonstrated that NEAT1 up-regulated glioma cells and negatively correlated with miR-98-5p in glioma tissues. A potential binding region between NEAT1 and miR-98-5p was confirmed by dual-luciferase assays. Basic leucine zipper and W2 domain containing protein 1 (BZW1) was identified as a direct target of miR-98-5p. We also identified that BZW1 was positively correlated with NEAT1 in glioma tissues. NEAT1 knockdown inhibited glioma cell proliferation in vivo via miR-98-5p/BZW1. Yes NEAT1 knockdown inhibited glioma cell proliferation. The inhibition of miR-98-5p rescued the knockdown of NEAT1 in glioma cells. 33393590 hsa_circ_0042666 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Regulation[miR-223/TGFBR3 axis] IHC//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In our present study, we identified a novel circRNA hsa_circ_0042666, which was poorly expressed in LSCC.In mechanism, our data indicated that hsa_circ_0042666 could competitively bind to miR-223 as a miRNA sponge to regulate TGFBR3 expression in LSCC progression. Altogether, these findings elucidated that hsa_circ_0042666 regulated LSCC cells proliferation and invasion by miR-223/TGFBR3 axis, which might provide a therapeutic strategy for the treatment of LSCC. Low hsa_circ_0042666 expression was closely associated with advanced tumor stage, lymph-node metastasis, and poor overall survival. Yes In vitro function assays, we showed that hsa_circ_0042666 dramatically reduced LSCC cells proliferation and invasion in vitro. 31525642 NEAT1 LncRNA Homo sapiens Glioma glioma tissues Interaction(miR‑324‑5p/KCTD20 axis) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining By reverse transcription‑quantitative PCR and fluorescence in situ hybridization analysis, NEAT1 expression was upregulated in glioma tissues compared with in adjacent normal brain tissues, and elevated NEAT1 levels were associated with poor prognosis. Using bioinformatics analysis, RNA immunoprecipitation experiments and luciferase reporter assays, it was demonstrated that NEAT1 may competitively bind to microRNA (miR)‑324‑5p, thus blocking its interaction with target mRNAs. Potassium channel tetramerization protein domain containing 20 (KCTD20) was identified as a specific miR‑324‑5p target. Yes Knockdown of NEAT1 in glioma cell lines was associated with cell cycle arrest at the G0/G1 phase, decreased proliferation and elevated apoptosis in vitro, and resulted in reduced tumor growth and increased survival in a mouse xenograft model of glioma. 33982764 circHACE1 CircRNA Homo sapiens Thyroid Neoplasms THCA tissues and adjacent non-cancerous tissues Interaction(miR-346) In Vivo Experiment//RNA Pull-Down//Western Blot//Invasion Assay//Migration Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis We verified that circHACE1 was downregulated in differentiated THCA. CircHACE1 could function as a microRNA (miR)-346 sponge and regulated Tfcp2L1 (transcription factor CP2 like 1) expression. Also, differentiated THCA patients with low circHACE1 expression were associated with TNM grade, lymphoid node metastasis, tumor size, and poor prognosis. Yes CircHACE1 overexpression decreased xenograft tumor growth in vivo and induced cell cycle arrest, apoptosis, impeded proliferation, migration, and invasion in differentiated THCA cells in vitro. 34092745 hsa_circ_0120175 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Interaction(miR-330-3p/SLC7A11 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay Circ_0120175 abundance was aberrantly increased in LSCC tissues and cell lines, and LSCC patients with high level of circ_0120175 were associated with advanced tumor staging, lymph node metastasis and short survival time. Circ_0120175 could sponge and negatively regulate miR-330-3p expression in LSCC cells. The addition of anti-miR-330-3p partly reversed circ_0120175 knockdown-induced effects in LSCC cells. SLC7A11 bound to miR-330-3p. Circ_0120175 enhanced the abundance of SLC7A11 through sponging miR-330-3p in LSCC cells. Circ_0120175 abundance was aberrantly increased in LSCC tissues and cell lines, and LSCC patients with high level of circ_0120175 were associated with advanced tumor staging, lymph node metastasis and short survival time. Yes Circ_0120175 interference suppressed cell proliferation, migration and invasion and induced cell apoptosis of LSCC cells. 35142935 NEAT1 LncRNA Homo sapiens Glioblastoma cell line Regulation(EGFR/STAT3 and NFκB (p65) ) In Vivo Experiment//cell invasion assay//IHC//Western Blot//Co-IP//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//H&E Staining//Cell Proliferation Assay//Colony Formation Assay We found that NEAT1 levels were regulated by EGFR pathway activity, which was mediated by STAT3 and NFκB (p65) downstream of the EGFR pathway.Taken together, we found that NEAT1 could bind to EZH2 and mediate the trimethylation of H3K27 in their promoters. Yes Moreover, we found that NEAT1 was critical for glioma cell growth and invasion by increasing β-catenin nuclear transport and downregulating ICAT, GSK3B, and Axin2. NEAT1 depletion also inhibited GBM cell growth and invasion in the intracranial animal model. 29138341 hsa_circ_0044520 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cells Interaction(miR-338-3p/ROR2 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay The expression of circ_0044520 and ROR2 was increased in LSCC tissues and cells, while the expression of miR-338-3p was decreased. Circ_0044520 can sponge miR-338-3p, and ROR2 is the target of miR-338-3p. Mechanically, circ_0044520 regulates ROR2 expression in LSCC cells by sponging miR-338-3p. In addition, in vivo studies have shown that down-regulation of circ_0044520 inhibits tumor growth. Yes In vitro complement experiments showed that knockdown of circ_0044520 significantly inhibited malignant behavior of LSCC, while co-transfection of miR-338-3p inhibitor partially up-regulated this change. In addition, miR-338-3p can inhibit the proliferation of LSCC cells, while co-transfection of overexpression of ROR2 can partially reverse this change. 35037694 hsa_circ_0005033 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cells Interaction(miR-107/IGF1R axis) In Vivo Experiment//Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay Expression of circ_0005033 was substantially upregulated in LSCC tissues and cells, and allied with miR-107 downregulation and IGF1R upregulation. Essentially, circ_0005033 and IGF1R were competing endogenous RNAs for miR-107 via target binding.Allied with that, cleaved-caspase 3/8/9 expression was elevated via death receptor-mediated and mitochondrial pathways, and expression of matrix metalloproteinase-2 (MMP2), MMP9, cyclin D1 and proliferating cell nuclear antigen was decreased. Moreover, Cisplatin-induced inhibition of cell viability was exacerbated by inhibiting circ_0005033. These functional effects of circ_0005033 depression were consistent with those of miR-107 overexpression. Furthermore, depleting miR-107 and restoring IGF1R abated the effects of circ_0005033 knockdown and miR-107 overexpression, respectively. Yes Silencing circ_0005033 facilitated apoptosis rate and lowered cell viability, proliferation, migration and invasion of LSCC cells, as well as delayed xenograft tumor growth. 34845162 NEAT1 LncRNA Homo sapiens Multiple Myeloma MM patients and MM cell lines Regulation[PI3K/AKT pathway] qRT-PCR//Western Blot NEAT1 and SOX13 were highly expressed in MM patients and MM cell lines, and the patient survival rate and platelet count were significantly decreased in the highly expressed NEAT1 group. Highly expressed NEAT1 promoted cell proliferation through activation of PI3K/AKT pathway, thus participating in the development of MM. NEAT1 and SOX13 were highly expressed in MM patients and MM cell lines, and the patient survival rate and platelet count were significantly decreased in the highly expressed NEAT1 group. Yes Low expression of NEAT1 could inhibit the PI3K/AKT pathway to suppress cell proliferation, promote apoptosis, and inhibit cell cycle. 30338809 circSHKBP1 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC specimens and cell lines Interaction(miR-766-5p/HMGA2 ) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay circSHKBP1 expression was up-regulated in the LSCC specimens and cell lines. Mechanistic analysis clarified that circSHKBP1 sponged miR-766-5p to regulate HMGA2, the target of miR-766-5p. Moreover, miR-766-5p inhibition and overexpression of HMGA2 rescued the tumor-suppressing roles of circSHKBP1 downregulation in LSCC. In conclusion, circSHKBP1 accelerated the tumorigenesis of LSCC via modulating HMGA2 by targeting miR-766-5p. And elevated circSHKBP1 expression was closely linked to poor prognosis. However, HMGA2 was highly expressed and positively associated with circSHKBP1 in these specimens. Importantly, the levels of circSHKBP1, miR-766-5p, and HMGA2 were closely associated with patients' clinical parameters including lymph nodes metastasis and TNM stages. Yes Silencing circSHKBP1 expression restrained cell proliferation, invasion, angiogenesis, stem cell-like properties and tumor growth. 35502885 MIR155HG LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-155-5p and TYRP1) Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay The present study indicated that the expression levels of miR155HG and tyrosinase-related protein 1 (TYRP1) were significantly increased, whereas that of miR155-5p was decreased in OC tissues and cells. Mechanistically, it was revealed that miR155HG and TYRP1 were both targeted by miR-155-5p with complementary binding sites in the 3' untranslated region. A dual-luciferase reporter assay was used to confirm the targeting relationship between miR155HG, miR-155-5p and TYRP1. Yes It was demonstrated that knockdown of miR155HG markedly inhibited OC cell viability, migration and invasion while promoting apoptosis, as indicated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, wound healing, Transwell and western blot assays. 34539833 hsa_circ_0000144 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(miR-1178-3p/YWHAH axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Tube Formation Assay//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//IHC//Invasion Assay//Transwell Assay Circ_0000144 and YWHAH were upregulated in PTC tissues and cells, while miR-1178-3p had an opposite result.Circ_0000144 acted as a molecular sponge for miR-1178-3p, which targeted YWHAH. MiR-1178-3p inhibitor reversed circ_0000144 silencing-mediated influence on PTC cell malignancy and angiogenesis. Yes Circ_0000144 silencing constrained PTC cell growth in vitro and in vivo and induced apoptosis and repressed migration, invasion, and angiogenesis of PTC cells in vitro. 35902926 circSLC25A16 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue Expression[highly expressed] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay In the NSCLC tissue, circSLC25A16 was upregulated comparing to normal tissue (Fig. ​(Fig.1g).1g). Collectively, present research reveals the crucial function of circSLC25A16 on NSCLC glycolysis through miR-488-3p/HIF-1α/LDHA, suggesting the underlying pathogenesis for NSCLC and providing a therapeutic strategy for precise treatment. Yes Besides, circSLC25A16 knockdown repressed the in vivo growth by xenograft assays. 32513983 circMYLK CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cell lines Regulation[ microRNA-195/cyclin D1 axis ] qRT-PCR//MTT//Luciferase Report Assay//Western Blot We found that circMYLK was highly expressed in LSCC tissues and cell lines. Mechanistically, circMYLK can serve as a competing endogenous RNA for miR-195 to increase cyclin D1 expression in LSCC, and rescue experiments further showed that restoration of miR-195 could block the oncogenic role of circMYLK in LSCC. In conclusion, our findings indicate that the circMYLK/miR-195/cyclin D1 regulatory axis could affect the proliferation and cell cycle progression of LSCC cells, and may provide a novel therapeutic target for the treatment of LSCC. Yes circMYLK overexpression promoted LSCC cell proliferation and G1/S cell cycle transition; whereas circMYLK knockdown had the contrary effects. 31427478 MIR155HG LncRNA Homo sapiens Pancreatic Neoplasms PC tissues,cell lines Interaction[miR-802] qRT-PCR In this research, our group found that lncRNA MIR155HG expression was remarkably increased in PC tumor tissue and cells compared to that in the adjacent normal tissue and cells.We performed bioinformatics analysis to search for the target of MIR155HG. As demonstrated by Luciferase reporter assay, we found that miR-802, a tumor suppressor in various cancer, is a direct target of MIR155HG. We demonstrated that the tumor-promoting effects of MIR155HG were contributed by negative regulation of miR-802 in PC cells. In summary, our results suggest that lncRNA MIR155HG might be applied as a novel diagnostic and therapeutic target for PC. Yes In addition, we exhibited that silence of MIR155HG by short hairpin RNA knockdown significantly inhibited cell growth and promoted cell apoptosis in PC cells. 31161625 MIR155HG LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Regulation[miR-155-5p/SOX10 axis] Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay It was revealed that MIR155HG and miR‑155‑5p were significantly upregulated in LSCC tissues, and were associated with the TNM stage, pathological differentiation and lymph node metastasis.On the whole, the findings of the present study indicate a novel role of MIR155HG in the TGF‑β‑induced EMT of LSCC cells by regulating EMT markers through the miR‑155/SOX10 axis. The MIR155HG/miR‑155‑5p/SOX10 axis plays an important role in promoting the progression of LSCC and may thus serve as a potential therapeutic target for LSCC treatment. It was revealed that MIR155HG and miR‑155‑5p were significantly upregulated in LSCC tissues, and were associated with the TNM stage, pathological differentiation and lymph node metastasis. Yes Moreover, the knockdown of MIR155HG and miR‑155‑5p inhibited the proliferation, migration and invasion of LSCC cells, whereas their overexpression exerted the opposite effects in vitro and MIR155HG overexpression promoted tumorigenesis in vivo. 31081043 hsa_circ_100395 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines Regulation(PI3K/AKT/mTOR signaling pathway) Western Blot//BrdU//Flow Cytometry//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay Decreased circ_100395 expression was shown in PTC tissues and cell lines. Circ_100395 overexpression significantly reduced aerobic glycolysis and the survival, migration and invasion abilities and downregulated phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, which were reversed by the PI3K activator 740Y-P. Yes Circ_100395 overexpression significantly reduced aerobic glycolysis and the survival, migration and invasion abilities and downregulated phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, which were reversed by the PI3K activator 740Y-P. 35447227 NEAT1 LncRNA Homo sapiens Multiple Myeloma Bone marrow Regulation[JAK2/STAT3 signaling pathway] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//ELISA NEAT1 and B7-H3 were up-regulated, but miR-214 was obviously down-regulated in MM patients. NEAT1 directly targeted miR-214, and miR-214 directly bound to B7-H3. MiR-214 inhibitor reversed the down-regulation and release of B7-H3 and M2 macrophage polarization caused by shNEAT1. The specific JAK2/STAT3 signaling inhibitor AG490 abrogated M2 macrophage polarization. B7-H3, NEAT1 and miR-214 were associated with overall survival time of MM patients. Yes NEAT1 silencing induced miR-214 and inhibited the expression and release of B7-H3 and then suppressed M2 macrophage polarization via inhibiting the JAK2/STAT3 signaling. 31731055 NONHSAT113026 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues Interaction[NF-κB/p50 and SLUG] qRT-PCR Compared to the adjacent tissues, NOAT113026 was noticeably downregulated in RCC. Overexpression of NOAT113026 can decrease the ability of cell migration, invasion, proliferation, and colony formation by regulating NF-κB/p50 and SLUG through a mechanism that involves lncRNA-mRNA interactions. Survival analysis showed that the lower the expression level of NOAT113026 was, the shorter the disease-free survival and overall survival in RCC would be. Yes Overexpression of NOAT113026 can decrease the ability of cell migration, invasion, proliferation, and colony formation by regulating NF-κB/p50 and SLUG through a mechanism that involves lncRNA-mRNA interactions. 31545257 MIR155HG LncRNA Homo sapiens Carcinoma, Renal Cell cell lines Interaction[MIR155HG/miR-155-5p/-3p ] CCK8//qRT-PCR//Western Blot//Transwell Assay In the current research, the expression of MIR155HG was increased in ccRCC. Blocking lncRNA MIR155HG/miR-155-5p/-3p inhibits proliferation, invasion and migration of renal clear cell carcinoma, which provided a new method for early diagnosis and precise treatment of ccRCC. Yes Interference of MIR155HG inhibited the cellular functions of ccRCC cells, which was reversed by overexpression of miR-155-3p and miR-155-5p. 31889587 MIR155HG LncRNA Homo sapiens Melanoma macrophages Regulation Western Blot//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Transwell Assay Interestingly, M1 macrophages expressed lower, while M2 macrophages expressed higher levels of MIR155HG. These evidences suggest that MIR155HG knockdown may inhibit melanoma cell proliferation, aberrant MIR155HG levels correlate with the regulation of M1/M2 macrophage balance and macrophage infiltration in tumor microenvironment. Yes The results showed that MIR155HG knockdown markedly reduced cell viability, suppressed colony formation, arrested the cell cycle at G1 phase and promoted apoptosis of A375 and SK-MEL-28 cells. More importantly, we also found that CM from A375 cells knocking down MIR155HG favored M1 polarization and ameliorated macrophage infiltration, while CM from MIR155HG overexpressing cells promoted M2 polarization and accelerated macrophage infiltration. 35182814 NONHSAT114552 LncRNA Homo sapiens Chordoma chordoma tissue Interaction( miR-320d/NRP1) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis NONHSAT114552 was overexpressed while miR-320d was down-regulated in chordoma tissue compared to fetal nucleus pulposus. In vitro studies confirmed that NONHSAT114552 acted as ceRNA to regulate NRP1 by directly sponging miR-320d, thus facilitating chordoma cell proliferation and invasion. Kaplan-Meier survival analysis showed that NONHSAT114552 overexpression was associated with patients' poor prognosis. Yes Knockdown of NONHSAT114552 significantly suppressed chordoma cell proliferation and invasion.In vivo study demonstrated that NONHSAT114552 moderated chordoma growth by sponging miR-320d to regulating NRP1. 34721048 MIR155HG LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue regulation[MIR155HG/miR-155 axis] qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Data obtained from the GEO dataset show that MIR155HG is frequently overexpressed in NSCLC tumor tissues and cell lines. Current findings indicate that MIR155HG/miR-155 axis facilitates NSCLC progression by downregulating TP53INP1. Elevated MIR155HG levels were found to be associated with advanced disease stage and poor prognosis of NSCLC. Yes Cell viability, as well as the capability of migration and invasion of NCI-H1975 and A549 cells, was markedly reduced upon MIR155HG knockdown. 32432745 NONHSAT105177 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC cancer tissues Expression[lower expressed] qRT-PCR NONHSAT105177 expression was significantly lower in PDAC cancer tissues than in adjacent noncancerous tissues. Yes Additionally, overexpression of NONHSAT105177 inhibited PDAC cell proliferation, migration, and the epithelial-mesenchymal transition (EMT), both in vitro and in vivo. 30237397 circMYOF CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cells Interaction(miR-145-5p/OTX1 regulatory axis ) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//Invasion Assay CircMYOF was upregulated in LSCC tissues and cells, and its knockdown suppressed LSCC cell growth, metastasis, and glycolysis, as well as inhibited LSCC tumor growth. Our data revealed that circMYOF contributed to LSCC progression by promoting cell growth, metastasis, and glycolysis through miR-145-5p/OTX1 axis. Yes CircMYOF was upregulated in LSCC tissues and cells, and its knockdown suppressed LSCC cell growth, metastasis, and glycolysis, as well as inhibited LSCC tumor growth. 35474406 NEAT1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Regulation[Wnt/β-Catenin Signaling] CCK8//qRT-PCR//Transwell Assay Our data revealed that NEAT1 is upregulated, while miR-34a-5p is downregulated in NPC tissues and cell lines. Additionally, we discovered that NEAT1 directly binds to miR-34a-5p and suppresses miR-34a-5p expression. Moreover, NEAT1 knockdown exerted suppression effects on cell proliferation, migration, invasion, and EMT by miR-34a-5p. NEAT1 knockdown blocked Wnt/β-catenin signaling via miR-34a-5p. Yes Our data revealed that NEAT1 is upregulated, while miR-34a-5p is downregulated in NPC tissues and cell lines. 30900419 NEAT1 LncRNA Homo sapiens Glioma glioma specimens and cells Interaction(miR-128-3p/ITGA5 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tunel//Flow Cytometry//qRT-PCR//FISH//RIP//IF//Luciferase Report Assay//Transwell Assay As a result, high expression of NEAT1 and lack of miR-128-3p were observed in glioma specimens and cells. Collectively, these results indicated that the NEAT1/miR-128-3p/ITGA5 axis was involved in glioma initiation and progression, and might offer a potential novel strategy for treatment of glioma. Yes . By binding to anti-oncogene miR-128-3p in the nucleus, NEAT1 enhanced tumorigenesis and glioma development. 34263426 hsa_circ_0067934 CircRNA Homo sapiens Thyroid Neoplasms thyroid cancer cell Interaction(miR-545-3p/SLC7A11 Signaling) In Vivo Experiment//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay Our data showed that the ferroptosis activator erastin decreased thyroid cancer cell viabilities, while the circ_0067934 shRNA further attenuated erastin-inhibited cell viabilities. Circ_0067934 upregulated the expression of the ferroptosis-negative regulator SLC7A11 by sponging and inhibiting miR-545-3p in thyroid cancer cells. The overexpression of SLC7A11 or the inhibitor of miR-545-3p reversed circ_0067934 silencing-regulated thyroid cancer cell proliferation. Yes Our data showed that the ferroptosis activator erastin decreased thyroid cancer cell viabilities, while the circ_0067934 shRNA further attenuated erastin-inhibited cell viabilities. The silencing of circ_0067934 enhanced the levels of ferroptosis-related markers, including Fe2+, iron, and ROS in the cells. The knockdown of circ_0067934 induced thyroid cancer cell apoptosis and repressed thyroid cancer cell proliferation in vitro and in vivo. 34290668 circRASSF2 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues Regulation[miR-302b-3p/IGF-1R axis] Western Blot//Luciferase Report Assay//Microarray circRASSF2 was found to be significantly up-regulated in LSCC tissues and LSCC cell lines compared with paired adjacent non-tumorous tissues and normal cells.In conclusion, these data suggest that circRASSF2 is a central component linking circRNAs to progression of LSCC via an miR-302b-3p/IGF-1R axis. Yes Moreover, knockdown of circRASSF2 significantly inhibited cell proliferation and migration in vitro, which was blocked by miR-302b-3p inhibitor. 30992382 circPARD3 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues regulation[PRKCI-Akt-mTOR pathway] RNA Pull-Down//Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay Autophagy was inhibited in LSCC, and circPARD3 was upregulated in the LSCC tissues (n = 100, p < 0.001). Our study reveals that the novel autophagy-suppressive circPARD3 promotes LSCC progression and chemoresistance through the PRKCI-Akt-mTOR pathway, providing new insights into circRNA-mediated autophagy regulation and potential biomarker and target for LSCC treatment. High circPARD3 level was associated with advanced T stages (p < 0.05), N stages (p = 0.001), clinical stages (p < 0.001), poor differentiation degree (p = 0.025), and poor prognosis (p = 0.002) of LSCC patients (n = 100). Yes Functionally, circPARD3 inhibited autophagy and promoted LSCC cell proliferation, migration, invasion and chemoresistance. 33234130 NONHSAT070806 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cells Expression(lower expressed) qRT-PCR//Wound Healing Assay//Transwell Assay We identified a novel sense lncRNA, NONHSAT070806, that was downregulated in BC tissues and cells and negatively correlated with level of tumor invasion in patients. Furthermore, overexpression of NONHSAT070806 induced apoptosis of T24 and 5637 cells, inhibited the proliferation, migration and invasion of BC cells, and attenuated the tumorigenesis of BC cells both in vitro and in vivo. We identified a novel sense lncRNA, NONHSAT070806, that was downregulated in BC tissues and cells and negatively correlated with level of tumor invasion in patients. Yes Furthermore, overexpression of NONHSAT070806 induced apoptosis of T24 and 5637 cells, inhibited the proliferation, migration and invasion of BC cells, and attenuated the tumorigenesis of BC cells both in vitro and in vivo. 36507479 NONHSAT076754 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial  EOC tissue,cell lines(SKOV3,OVCAR5,OVCAR3,OVCAR8,HO8910,HOSEPIC) Expression[highly expressed] qRT-PCR//Wound Healing Assay//Western Blot//Migration Assay The results showed that NONHSAT076754 expression was increased in EOC tissues and cell lines and that this expression was closely related with FIGO stage, high tumor grade and lymph node metastasis. Yes Furthermore, NONHSAT076754 knockdown markedly inhibited EOC cell migration and invasion in vitro. 31205552 NONHSAT079852.2 LncRNA Homo sapiens Glioblastoma recurrent GBM Interaction(miR-10401-3p/HSPA1A ) Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//FISH//Flow Cytometry//RNA-seq//Luciferase Report Assay//Colony Formation Assay//Invasion Assay qRT-PCR revealed that NONHSAT079852.2 was significantly elevated in recurrent GBM relative to that in primary GBM, and high NONHSAT079852.2 expression was associated with the poor overall survival rates of patients with GBM.NONHSAT079852.2 was identified to be a sponge for hsa-miR-10401-3p through luciferase reporter assay. Moreover, HSPA1A was targeted and regulated by hsa-miR-10401-3p. qRT-PCR revealed that NONHSAT079852.2 was significantly elevated in recurrent GBM relative to that in primary GBM, and high NONHSAT079852.2 expression was associated with the poor overall survival rates of patients with GBM. Yes The knockdown of NONHSAT079852.2 successfully induced tumor cell apoptosis, inhibited the proliferation, migration, invasion and the expression level of HSPA1A in glioma cells. 34307121 circCORO1C CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cells regulation[let-7c-5p/PBX3 axis] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay circCORO1C was highly expressed in LSCC tissues and cells, and this high expression was closely associated with the malignant progression and poor prognosis of LSCC. Mechanistic studies revealed that circCORO1C competitively bound to let-7c-5p and prevented it from decreasing the level of PBX3, which promoted the epithelial-mesenchymal transition and finally facilitated the malignant progression of LSCC. circCORO1C was highly expressed in LSCC tissues and cells, and this high expression was closely associated with the malignant progression and poor prognosis of LSCC. Yes Knockdown of circCORO1C inhibited the proliferation, migration, invasion, and in vivo tumorigenesis of LSCC cells. 32487167 hsa_circ_100290 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cell lines regulation[miR-136-5p/RAP2C axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining Here, we found that circRNA_100290 expression was significantly upregulated in LSCC tissues and cell lines compared with the normal controls. Our findings suggest that circRNA_100290 promotes LSCC progression by targeting the miR-136-5p/RAP2C axis, which may lead to the identification of potential therapeutic targets. Expression of circRNA_100290 positively correlated with advanced TNM stage and lymph node metastasis in LSCC patients. Yes In cell culture, upregulation of circRNA_100290 promoted LSCC cell proliferation, migration, and invasion, while it inhibited cell apoptosis; downregulating circRNA_100290 exerted the opposite effects. 32014687 circPPFIA1 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues Interaction(miR-340-3p ) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//qPCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We verified the expression of circPPFIA1 and found that it was upregulated in LSCC tissues compared to the adjacent normal tissues. Mechanistically, miR-340-3p was predicted to be the target miRNA sponged by circPPFIA1 as confirmed through the luciferase assay and rescue experiments. Yes These results suggest that circPPFIA1 knockdown can suppress the proliferation, migration, and invasion of LSCC cells, while circPPFIA1 overexpression can promote these processes. 34455918 MIR17HG LncRNA Homo sapiens Retinoblastoma RB samples Interaction(miR-155-5p/HIF-1α axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We found that MIR17HG expression was significantly up-regulated in RB samples, which was negatively correlated with miR-155-5p expression. MiR-155-5p suppressed the proliferation, migration, and invasion of RB cells. MIR17HG positively regulated the expression of HIF-1α on both mRNA and protein levels in RB cells. Additionally, miR-155-5p was identified as a target of MIR17HG. The data in this study suggest that MIR17HG exerts oncogenic effects in RB via the miR-155-5p/HIF-1α axis. Yes The proliferation, migration, and invasion of RB cells were promoted by MIR17HG overexpression but inhibited by MIR17HG knockdown. 35253975 hsa_circ_0042823 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC cell lines (AMC-HN-8 and TU686) Interaction(miR-877-5p/FOXM1 axis) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay Compared with normal human bronchial epithelial cells (HBECs), hsa_circ_0042823 was highly expressed in the LSCC cell lines (AMC-HN-8 and TU686). Further studies demonstrated that hsa_circ_0042823 interacted with miR-877-5p, and FOXM1 was the target of miR-877-5p. Yes Hsa_circ_0042823 overexpression promoted proliferation, migration and invasion of AMC-HN-8 cells through regulating miR-877-5p/FOXM1 axis. Additionally, inhibition of hsa_circ_0042823 inhibited growth of LSCC in vivo via miR-877-5p/FOXM1 axis. 34124974 NEAT1 LncRNA Homo sapiens Glioma glioma cell Regulation(PGK1) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Colony Formation Assay NEAT1 knockdown significantly suppressed the proliferation and glycolysis of glioma cells. NEAT1 could specifically interact with PGK1, which promotes PGK1 stability. Hairpin A of NEAT1 is essential for interaction with M1 domain of PGK1. Depletion of NEAT1 markedly inhibited tumor growth in mice, while PGK1 could reverse this effect. Higher expression of NEAT1 was associated with poor overall survival of GBM patients. Higher expression of NEAT1 was associated with poor overall survival of GBM patients. Yes NEAT1 knockdown significantly suppressed the proliferation and glycolysis of glioma cells. 35123484 circSEPT9 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC Interaction(miR-10a) CCK8//qRT-PCR CircSEPT9 was highly expressed in LSCC, whereas miR-10a was expressed at a lower level in LSCC. CircSEPT9 and miR-10a were closely correlated across LSCC tissue samples. Yes In LSCC cells, circSEPT9 overexpression increased the methylation of the miR-10a gene and decreased the expression of miR-10a. CircSEPT9 overexpression increased LSCC cell proliferation, whereas miR-10a overexpression decreased cell proliferation. 34936289 hsa_circ_0023305 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues Interaction(TRPM7 via miR-218-5p Sponging) In Vivo Experiment//FISH//Bioinformatics Analysis//qRT-PCR Recent investigations using bioinformatics analysis revealed high expression of hsa_circ_0023305 in LSCC tissues compared to normal tissues. In summary, these data propose a new mechanism by which the hsa_circ_0023305/miR-218-5p/TRPM7 network enhances LSCC progression. . Furthermore, we discovered that hsa_circ_0023305 expression level was positively correlated to tumor/node/metastasis (TNM) stage as well as lymph node metastasis in LSCC. Moreover, higher hsa_circ_0023305 levels were correlated to poorer LSCC patient outcomes. Yes Knockdown of hsa_circ_0023305 significantly inhibited LSCC cell proliferation, invasion, and migration abilities. 34901284 circZFR CircRNA Homo sapiens Thyroid Neoplasms TC cells Interaction(miR-16/MAPK1 axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay Results showed that circZFR was upregulated and miR-16 was downregulated in TC cells. Moreover, circZFR positively regulated MAPK1 expression in TC cells by serving as a ceRNA of miR-16. Yes CircZFR knockdown inhibited the viability and invasion and induced apoptosis in TC cells. Mechanistically, circZFR knockdown-induced inhibition of cell viability and invasion and promotion of apoptosis were overturned after miR-16 downregulation and promotion of MAPK1. 34323000 MIR503HG LncRNA Homo sapiens Vascular Diseases primary endothelial cells Regulation Other Importantly, the phenotypic changes induced by MIR503HG were independent of miR-424 and miR-503, which overlap the lncRNA locus. We also revealed that MIR503HG interacts with the PTBP1 (Polypyrimidine Tract Binding Protein 1) and regulates its protein level. PTBP1 regulation of EndMT markers suggests that the role of MIR503HG in EndMT might be mediated in part by PTBP1. Yes MIR503HG depletion induced a spontaneous EndMT phenotype, while its overexpression repressed hallmark EndMT changes, regulating 29% of its transcriptome signature. Overexpression of human MIR503HG in SuHx mice led to reduced mesenchymal marker expression, suggesting MIR503HG therapeutic potential. 33703914 MILIP LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues and cells Regulation Invasion Assay//Migration Assay//qRT-PCR//RNA-seq//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Importantly, high expression of MAFG-AS1 indicated advanced stage prostate cancer. Importantly, high expression of MAFG-AS1 indicated advanced stage prostate cancer. Univariate and Multivariate Cox regression analyses showed that high MAFG-AS1 expression was independently correlated with poor progression-free interval (PFI). Yes In addition, gene functional enrichment analysis revealed that MAFG-AS1 may be involved in ribosome biogenesis, ribonucleoprotein complex subunit organization, ribonucleoprotein complex assembly, rRNA metabolic process, structural constituent of ribosome, and ribonucleoprotein complex binding. 35992831 MILIP LncRNA Homo sapiens Carcinoma, Renal Cell primary ccRCC tissues Interaction(YBX1/Snai1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//RIP//Invasion Assay//Transwell Assay MILIP expression was upregulated in metastatic compared with primary ccRCC tissues. The increased MILIP expression in metastatic ccRCC cells was driven by the transcription factor AP-2 gamma (TFAP2C). Mechanistically, MILIP formed an RNA-RNA duplex with the snail family transcriptional repressor 1 (Snai1) mRNA and bound to Y-box binding protein 1 (YBX1). Yes Knockdown of MILIP diminished the potential of ccRCC cell migration and invasion in vitro and reduced the formation of ccRCC metastatic lesions in vivo. The effect of MILIP on ccRCC cells was associated with alterations in the expression of epithelial-to-mesenchymal transition (EMT) hallmark genes. 36028903 MIAT LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines regulation[ PI3K/Akt signalling pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay Our results show that MIAT was up-regulated in cervical cancer tissues and cell lines. Mechanically, knocking down MIAT suppressed the activation of PI3K/Akt signalling pathway. Yes Knocking down MIAT resulted in decreased cell proliferation, migration and invasion of cervical cancer cells and suppression of tumour growth in mice. 32239132 MT-CO2 LncRNA Homo sapiens Pulmonary Arterial Hypertension blood regulation[ LincRNA-COX2/miR-let-7a/STAT3 axis] CCK8//qRT-PCR//Wound Healing Assay//Flow Cytometry In peripheral blood samples from PAH patients and hypoxic PASMCs, lincRNA-COX2 expression was enhanced. LincRNA-COX2/miR-let-7a/STAT3 axis might be considered as a novel target to treat PAH. Yes Silencing lincRNA-COX2 inhibited hypoxia-induced PASMCs proliferation by influencing the G2/M phase of the cell cycle. 32803651 circNFIB1 CircRNA Homo sapiens Pancreatic Neoplasms PDAC tissues regulation[miR-486-5p/PIK3R1/VEGF-C axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RNA-seq In the present study, we identified that a novel circRNA (circNFIB1, hsa_circ_0086375) was downregulated in PDAC and negatively associated with LN metastasis in PDAC patients.Mechanistically, circNFIB1 functioned as a sponge of miR-486-5p, and partially reversed the effect of miR-486-5p. Moreover, circNFIB1 attenuated the oncogenic effect of miR-486-5p and consequently upregulated PIK3R1 expression, which further downregulated VEGF-C expression through inhibition of the PI3K/Akt pathway, and ultimately suppressed lymphangiogenesis and LN metastasis in PDAC. Yes Functionally, circNFIB1 knockdown promoted lymphangiogenesis and LN metastasis of PDAC both in vitro and in vivo. 32366257 NEAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines interaction[Sponging miR-153-3p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay These data showed that NEAT1 is highly expressed in NSCLC tissues and cell lines.Knockdown of NEAT1 could suppress cell proliferation, migration, and invasion of NSCLC while promoting cell apoptosis through sponging miR-153-3p. Yes Knockdown of NEAT1 suppresses cell proliferation, invasion, migration, and induces the cell apoptosis in NSCLC cell lines. 32380843 MIAT LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues regulation[MIAT-miR-150-CDKN1B signaling axis ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay The low expression of MIAT was characterized in cervical cancer, which associated with relatively poor prognosis.Our data highlighted the critical role of MIAT-miR-150-CDKN1B signaling axis in cervical cancer. The low expression of MIAT was characterized in cervical cancer, which associated with relatively poor prognosis. Yes Ectopic expression of MIAT inhibited malignant growth of cervical cancer both in vitro and in vivo. 32549789 MATN1-AS1 LncRNA Homo sapiens Osteosarcoma OS cells and tissues Interaction( miR-1299) qRT-PCR//RNA Pull-Down lnc MATN1-AS1 level was significantly elevated in OS cells and tissues and related to Enneking staging, lung metastasis, and histologic type. lnc MATN1-AS1 level was significantly elevated in OS cells and tissues and related to Enneking staging, lung metastasis, and histologic type. Patients with high lnc MATN1-AS1 level showed a shorter overall survival and recurrence-free survival. Yes Lnc MATN1-AS1 knockdown inhibited OS cell proliferation, migration, and invasion by sponging miR-1299. 34542816 hsa_circ_0000189 CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-192-5p-ZEB2 Axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining//Transwell Assay circ_0000189 was markedly overexpressed in glioma tissues and cell lines. Working as a competitive endogenous RNA, circ_0000189 directly targeted miR-192-5p, and repressed its expression, and circ_0000189 positively modulated ZEB2 expression indirectly via repressing miR-192-5p. Its high expression was associated with poor clinical pathological indicators and adverse MRI signs. Yes Gain-of-function experiments and loss-of-function experiments confirmed that circ_0000189 overexpression facilitated the proliferation and migration, as well as invasion of glioma cells, and suppressed apoptosis, and facilitated epithelial-mesenchymal transition (EMT) process. Compared to the control group, knocking down circ_0000189 suppressed the malignant phenotypes of glioma cells both in vivo and in vitro. 36193069 MIR503HG LncRNA Homo sapiens Triple Negative Breast Neoplasms breast cancer tissue,cell lines (MDA‐MB‐231 and TB549) Regulation[miR-103/OLFM4 axis] qRT-PCR//Luciferase Report Assay//Western Blot In our study, we found MIR503HG expression was significantly decreased in triple-negative breast cancer tissues and cell lines. Furthermore, we observed low MIR503HG expression was correlated with late clinical stage, lymph node metastasis and distant metastasis. In the survival analysis, we observed that triple-negative breast cancer patients with low MIR503HG expression had a statistically significant worse prognosis compared with those with high MIR503HG expression, and low MIR503HG expression was a poor independent prognostic factor for overall survival in triple-negative breast cancer patients.The study in vitro suggested MIR503HG inhibits cell migration and invasion via miR-103/OLFM4 axis in triple negative breast cancer. Yes we conducted loss‐ and gain‐of‐function experiments, and found MIR503HG expression inhibited cell migration and invasion in triple negative breast cancer cells. 31062436 circGNG4 CircRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues and cell lines Interaction(miR-223 ) RNA Pull-Down//IHC//Western Blot//qPCR//CCK8//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Findings of the present study confirmed that circRNA G protein subunit γ 4 (circGNG4) was upregulated in prostate cancer tissues and cell lines. Yes Knockdown of circGNG4 inhibited the malignant behavior of prostate cancer cells. Furthermore, bioinformatics were used to predict targeting interactions between circGNG4 or miR-223 and EYA transcriptional coactivator and phosphatase 3 (EYA3)/c-Myc mRNA. 34395419 circSLC8A1 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(miR-21) Cell Proliferation Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, our data revealed that circSLC8A1 was downregulated in PCa tissues and cells. In mechanism, circSLC8A1 exhibited a direct interaction with miR-21 and displayed as a miRNA sponge to inhibit PCa progression. Yes The reduction of circSLC8A1 resulted in the inhibition of cell proliferation and migration. 33869627 NEAT1 LncRNA Homo sapiens Sepsis sepsis tissues interaction[Irak2,miR-370-3p] Flow Cytometry//qRT-PCR//ELISA//Luciferase Report Assay NEAT1 and Irak2 were upregulated in sepsis tissues and LPS-induced RAW 264.7 and HL-1 cells, opposite to the expression of miR-370-3p.Knockdown of NEAT1 hampered sepsis progression by downregulating Irak2 via interacting with miR-370-3p in LPS-induced RAW 264.7 and HL-1 cells. Yes In addition, knockdown of NEAT1 promoted viability, suppressed apoptosis and reduced the expression of inflammatory cytokines in LPS-induced RAW 264.7 and HL-1 cells. 32414769 MIR503HG LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Interaction(miR-224-5p/HOXA9 axis) In Vivo Experiment//IHC//Western Blot//Transfection//Invasion Assay//Migration Assay//RIP//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Bioinformatics Analysis MIR503HG and HOXA9 expression were reduced in TNBC, while miR-224-5p was increased.Furthermore, MIR503HG promoted HOXA9 expression by inhibiting miR-224-5p. Overexpression of miR-224-5p reversed the effects of MIR503HG overexpression on TNBC cells, while overexpression of HOXA9 reversed the effect of MIR503HG knockdown. Additionally, an in vivo study proved that MIR503HG inhibited TNBC tumor growth via the miR-224-5p/HOXA9 axis. Yes Overexpression of MIR503HG or HOXA9 reduced the cell migration ability and proliferation and promoted apoptosis, and knockdown of MIR503HG or overexpression of miR-224-5p exhibited the opposite effects. 33869743 MIAT LncRNA Homo sapiens Glioma glioblastoma tumors Interaction(miR-29b-3p) Wound Healing Assay//Cell Apoptosis Assay//Cell Cycle Assay//Bioinformatics Analysis//IF our results revealed that the expression of MIAT was noticeably overexpressed in glioblastoma (p = < 0.0001). Moreover, knocking-down of MIAT reduced the expression of stemness factors, followed by upregulation of their downstream miRNAs (micro RNAs), let-7a-5p, and miR-29b-3p. We further found that the expression of MIAT was markedly upregulated in low-grade brain tumors rather than high-grade ones. Yes Inhibition of MIAT resulted in reduced proliferation of brain tumor cells followed by cell cycle arrest at the G1 phase, and significant induction of apoptosis, and senescence, but limited the migration ability and epithelial-mesenchymal-transition (EMT). 36352177 circTCF25 CircRNA Homo sapiens Glioma gliomas tissues and cells Interaction(circTCF25/miR-206/CypB axis ) In Vivo Experiment//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis circTCF25 was predominantly located in the cytoplasm; the combination of mir-206 and circTCF25 reverses the effects of knockdown of circTCF25 on the proliferation, migration, invasion, and tumorigenesis of glioma cells. Competitive binding between circTCF25 and miR-206 mainly upregulates target gene CypB expression by preventing its inhibition of the Jak2/p-stat3 pathway. In addition, knockdown of circTCF25 reduced CypB expression by inhibiting JAK2/p-stat3, which was rescued by treatment with a miR-206 inhibitor. In summary, our findings demonstrate that the circTCF25/miR-206/CypB axis plays a vital role in glioma progression, migration, invasion, and tumorigenesis. Yes circTCF25 was predominantly located in the cytoplasm; the combination of mir-206 and circTCF25 reverses the effects of knockdown of circTCF25 on the proliferation, migration, invasion, and tumorigenesis of glioma cells. Competitive binding between circTCF25 and miR-206 mainly upregulates target gene CypB expression by preventing its inhibition of the Jak2/p-stat3 pathway. In addition, knockdown of circTCF25 reduced CypB expression by inhibiting JAK2/p-stat3, which was rescued by treatment with a miR-206 inhibitor. 35384084 MBI‑52 LncRNA Homo sapiens Liver Cirrhosis CCl4‑induced mouse liver fibrosis models Interaction(microRNA‑466g/SMAD4 signaling pathway) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay lnc‑MBI‑52 was overexpressed in CCl4‑induced mouse liver fibrosis models and activated HSCs.In addition, lnc‑MBI‑52 and SMAD4 were identified as targets of miR‑466g. Yes Moreover, knockdown of lnc?MBI?52 downregulated α?smooth muscle actin and collagen type I expression. 34850963 MIR503HG LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cell lines Expression[lower expressed] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay The expression of MIR503HG was downregulated in bladder cancer tissues and cell lines. Low expression of MIR503HG was associated with advanced tumor stage, advanced histological grade, and lymph node metastasis. Yes Knockdown of MIR503HG promoted the cancer cell proliferation and increased the migration and invasion abilities of T24 cells. In addition, knockdown of MIR503HG reduced the cell apoptotic rate in cancer cells and promoted cell cycle progression. 30672010 MIAT LncRNA Homo sapiens Atherosclerosis blood Interaction[ MIAT/miR-149-5p /CD47 pathway] qRT-PCR//Luciferase Report Assay//RIP//Western Blot Here we show that lncRNA myocardial infarction associated transcript (MIAT) was markedly elevated in the serum of patients with symptoms of vulnerable atherosclerotic plaque and the macrophages of necrotic cores in an advanced atherosclerosis mouse model.Mechanistic studies revealed that MIAT acted as a micro RNA (miRNA) sponge to positively modulate the expression of anti-phagocytic molecule CD47 through sponging miR-149-5p. Together, these findings identified a macrophage MIAT/miR-149-5p /CD47 pathway as a key factor in the development of necrotic atherosclerotic plaques. Yes MIAT knockdown attenuated atherosclerosis progression, reduced necrotic core size, and increased plaque stability in vivo. Furthermore, MIAT knockdown promoted clearance of apoptotic cells by macrophages in vivo and in vitro. 30755588 MIAT LncRNA Homo sapiens Atherosclerosis human aortic endothelial cells Interaction(miR-214-3p/Caspase-1 signalling) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry The results found that lncRNA Miat was upregulated in ox-LDL-induced atherosclerosis model in vitro. LncRNA Miat and miR-214 has binding site, and CASP1, which encodes Caspase-1, is a target of miR-214. The downregulation of lncRNA Miat increased the expression of miR-214-3p and decreased the expression of Caspase-1, as well as its downstream molecule IL-1β in HAECs. Yes The inhibition of lncRNA Miat protects against ox-LDL-induced HAEC injury, presented as increased cell viability and decreased apoptosis. However, the inhibition of miR-214-3p attenuated the effect of lncRNA Miat downregulation on HAECs. Furthermore, the downregulation of lncRNA Miat alleviated atherosclerosis in ApoE-deficient mice. 34137063 MBLN1-AS1 LncRNA Rattus norvegicus Retinoblastoma retinoblastoma cell line Interaction(miR-338-5p-Wnt/β-catenin signaling pathway) Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay It was found that MBNL1-AS1 overexpression inhibited proliferation and migration in Y79 cells. In addition, the inhibitory effects of MBNL1-AS1 on Y79 cells were significantly reversed in the presence of miR-338-5p mimics, and MBNL1-AS1 overexpression significantly decreased miR-338-5p level in Y79 cells. Yes MBNL1-AS1 overexpression significantly inhibited Wnt/β-catenin signaling pathway, and this inhibitory effect was almost lost in the presence of miR-338-5p mimics.MBNL1-AS1 overexpression significantly inhibited Y79-induced retinoblastoma in mice, and this inhibitory effect was lost in the presence of miR-338-5p mimics. 33454803 MATN1-AS1 LncRNA Homo sapiens Glioma Glioma tissues Regulation[miR-200b/c/429-CHD1 axis] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay Meanwhile, MATN1-AS1 upregulation confirmed in glioma predicted poor clinical outcomes. Mechanistic investigations validated that MATN1-AS1 functioned as a ceRNA for miR-200b/c/429 to upregulate CHD1 which was also verified to exert a growth-promoting role in glioma cells here. Importantly, both CHD1 overexpression and miR-200b/c/429 inhibition could rescue the obstructive role of MATN1-AS1 silence in glioma cells. Yes Functionally, MATN1-AS1 knockdown restrained cell proliferation but stimulated apoptosis in vitro and repressed tumour growth in vivo. 31667976 MATN1-AS1 LncRNA Homo sapiens Glioblastoma glioblastoma tissues Regulation[MAPK signaling pathway] RNA Pull-Down//ChIP//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//IHC//Transwell Assay MATN1-AS1 was the most downregulated lncRNA in GBM and was correlated with a shorter survival time and poorer prognosis of GBM patients.Conversely, RELA was increased in GBM tumor tissues and negatively correlated with MATN1-AS1 expression. MATN1-AS1 over-expression or siRNA-RELA knockdown resulted in downregulation of mRNA and protein levels of RELA, ERK1/2, Bcl-2, survivin, and MMP-9; reduced cell proliferation and invasion; increased Bax mRNA and protein levels; and enhanced cellular apoptosis. MATN1-AS1 bound to E2F6, which negatively targeted RELA. Furthermore, MATN1-AS1 over-expression in GBM cells resulted in significant inhibition of tumor growth in vivo. MATN1-AS1 was the most downregulated lncRNA in GBM and was correlated with a shorter survival time and poorer prognosis of GBM patients. Yes Conversely, RELA was increased in GBM tumor tissues and negatively correlated with MATN1-AS1 expression. MATN1-AS1 over-expression or siRNA-RELA knockdown resulted in downregulation of mRNA and protein levels of RELA, ERK1/2, Bcl-2, survivin, and MMP-9; reduced cell proliferation and invasion; increased Bax mRNA and protein levels; and enhanced cellular apoptosis. 32042800 MAPT-AS1 LncRNA Homo sapiens Breast Neoplasms tissues and serum of BC patients Regulation( Wnt/β-catenin signaling pathway) Western Blot//Migration Assay//CCK8//Colony Formation Assay//Invasion Assay The expression of MAPT-AS1 was significantly up-regulated in tissues and serum of BC patients compared with controls (P<0.0001 for both). Overexpression of MAPT-AS1 activated the Wnt/β-catenin signaling pathway, promoting proliferation, migration, and invasion. Receiver operating characteristic (ROC) curve analysis showed that MAPT-AS1 had a large area under the curve (AUC) of 0.893. The expression of MAPT-AS1 in serum was closely related to the large tumor size, grade, tumor-node-metastasis (TNM) stages, and human epidermal growth factor receptor 2 (HER-2) expression status of BC patients. Yes Overexpression of MAPT-AS1 activated the Wnt/β-catenin signaling pathway, promoting proliferation, migration, and invasion. 35571636 NEAT1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL patients and cells Interaction(miR-495-3p/PD-L1 axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay NEAT1 was overexpressed in DLBCL patients. miR-495-3p was a target of NEAT1 and was decreased in DLBCL cells. However, inhibiting miR-495-3p reversed the effect of NEAT1 knock-down on DLBCL cells and induced the malignant behaviors of DLBCL cells. Moreover, NEAT1 functioned as a sponge of miR-495-3p to upregulate PD-L1. Yes Knockdown of NEAT1 reduced the viability while enhanced the apoptosis of tumor cells. However, overexpression of NEAT1 exhibited an opposite effect. 35352617 circDLC1 CircRNA Homo sapiens Glioma glioma tissues and cells Interaction( circDLC1/miR-671-5p/CTNNBIP1 ) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Bioinformatics Analysis//MeRIP//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining circDLC1 was poorly expressed in glioma. Mechanically, METTL3-mediated m6A modification enhanced circDLC1 stability and upregulated circDLC1 expression in glioma. circDLC1 upregulated CTNNBIP1 transcription by competitively binding to miR-671-5p. METTL3 overexpression repressed the malignant proliferation of glioma via circDLC1/miR-671-5p/CTNNBIP1 in vivo. Yes circDLC1 overexpression suppressed glioma cell proliferation. 35474040 circCDK14 CircRNA Homo sapiens Glioma glioma tissues and cell lines Regulation(miR-3938/PDGFRA axis) In Vivo Experiment//Wound Healing Assay//Transfection//Invasion Assay//qRT-PCR//FISH//RNA-seq//Bioinformatics Analysis//Transwell Assay Our findings indicated that circCDK14 was overexpressed in glioma tissues and cell lines, and elevated levels of circCDK14 induced poor prognosis of glioma patients. An evaluation of the underlying mechanism revealed that circCDK14 sponged miR-3938 to upregulate oncogenic gene PDGFRA expression. Moreover, we also found that circCDK14 reduced glioma cells' sensitivity to Fp by regulating PDGFRA expression. Our findings indicated that circCDK14 was overexpressed in glioma tissues and cell lines, and elevated levels of circCDK14 induced poor prognosis of glioma patients. Yes CircCDK14 promotes the migration, invasion and proliferation of glioma cells in vitro as well as tumorigenesis in vivo. 35002529 circPSMC3 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues regulation[downregulating DGCR8] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay CircPSMC3 was lowly expressed in PCa tissues compared with adjacent normal tissues.CircPSMC3 could suppress PCa cell migration and invasion by upregulating DGCR8. Yes The migration and invasion abilities of PCa cells were significantly inhibited after circPSMC3 was overexpressed in vitro. 32196577 NEAT1 LncRNA Homo sapiens stomach carcinoma gastric cancer tissues Interaction(miR‑500a‑3p/XBP‑1 axis) Western Blot//Transwell Assay//qPCR//CCK8//Luciferase Report Assay//Colony Formation Assay//IF lncRNA NEAT1 expression is upregulated in gastric cancer tissues. Yes Furthermore, the results indicated that lncRNA NEAT1 targeted and downregulated the expression of miR-500a-3p, and miR-500a-3p targeted X-box binding protein-1 (XBP-1) mRNA. lncRNA NEAT1 overexpression-mediated inhibition of gastric cancer cell proliferation and invasion was significantly reversed by miR-500a-3p overexpression.  33982777 circRHOT1 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues and cell lines interaction[sponging miR-125a-3p] qRT-PCR In this study, we demonstrated that circRHOT1 was overexpressed in pancreatic cancer tissues and cell lines, and it was found to directly bind to miR-125a-3p, acting as an endogenous sponge to inhibit its activity. Knockdown of circRHOT1 expression significantly inhibited proliferation as well as invasion, and it promoted apoptosis of pancreatic cancer cells via the regulation of E2F3 through the targeting of miR-125a-3p. Yes Knockdown of circRHOT1 expression significantly inhibited proliferation as well as invasion, and it promoted apoptosis of pancreatic cancer cells via the regulation of E2F3 through the targeting of miR-125a-3p. 32697386 hsa_circ_100395 CircRNA Homo sapiens Prostatic Neoplasms cancerous prostate tissues Interaction(miR-1228) Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay CircRNA_100395 expression was downregulated in cancerous prostate tissues relative to adjacent normal tissues. CircRNA_100395 expression was negatively correlated with tumor size, Gleason score, tumor stage, and lymph node metastasis. Yes Moreover, circRNA_100395 overexpression inhibited cell proliferation, altered cell cycle distribution, reduced cell migration and invasion abilities, and suppressed EMT in prostate cancer cells. Moreover, miR-1228 was a direct downstream target of circRNA_100395, and the anti-tumor ability of circRNA_100395 was significantly reversed by miR-1228. 33641485 NEAT1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse DLBCL tissues and cell lines regulation[miR-34b-5p-GLI1 pathway] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//ChIP NEAT1 and GLI1 were upregulated while miR-34b-5p was downregulated in DLBCL tissues and cell lines compared to normal controls. We revealed that MYC-regulated NEAT1 promoted DLBCL proliferation via the miR-34b-5p-GLI1 pathway, which could provide a novel therapeutic target for DLBCL. Yes Knockdown of NEAT1 or overexpression of miR-34b-5p inhibited cell proliferation but promoted cell apoptosis. 32206038 circDPP4 CircRNA Homo sapiens Prostatic Neoplasms 104 pairs of PCa tissues and matched adjacent normal prostate tissues Interaction(miR-195/cyclin D1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Cell Cycle Assay//EdU Staining//Transwell Assay We found that circDPP4 was overexpressed in PCa tissues and cell lines, and its expression was closely associated with Gleason score and clinical stage of PCa patients. We found that circDPP4 was overexpressed in PCa tissues and cell lines, and its expression was closely associated with Gleason score and clinical stage of PCa patients. Yes In vitro loss- and gain-of-function experiments demonstrated that circDPP4 knockdown inhibited, whereas circDPP4 overexpression promoted the proliferation, migration, invasion and cell cycle progression of PCa cells. Knockdown of circDPP4 also suppressed PCa tumor growth in vivo. We further found that circDPP4 functioned as a competing endogenous RNA (ceRNA) for miR-195 in PCa cells, and miR-195 negatively regulated the expression of oncogenic cyclin D1. 34271919 circFAM53B CircRNA Homo sapiens Glioma glioma tissues and cells Interaction(circFAM53B/miR-532-3p/c-MET/PI3K/AKT axis) In Vivo Experiment//IHC//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay As a result, circFAM53B was up-regulated in glioma tissues (vs. the matched non-tumor tissues). Mechanistically, bioinformatics analysis suggested that circFAM53B served as a competitive endogenous RNA (ceRNA) by sponging miR-532-3p, which targeted proto-oncogene (MET) and receptor tyrosine kinase (c-MET). miR-532-3p up-regulation delayed glioma development and inactivated the PI3K/AKT axis. Moreover, the treatment of the c-MET inhibitor SGX523, the PI3K inhibitor LY294002, and the Akt inhibitor MK-2206 reduced circFAM53B-mediated oncogenic effects. Higher levels of circFAM53B predicted poorer survival of glioma patients. Yes Functionally, circFAM53B up-regulation accelerated cell proliferation, colony formation, invasion and epithelial-mesenchymal transition (EMT), and heightened Bax/Bcl2 ratio.By contrast, circFAM53B down-regulation repressed glioma development in vitro. 35100091 MAT2B LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-431) Western Blot//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We observed that circMAT2B was overexpressed in NSCLC tissues and cell lines, and high expression of circMAT2B was closely associated with large tumor size, advanced TNM stage and poor prognosis of NSCLC patients. Mechanistically, circMAT2B could directly interact with miR-431, and subsequently decrease miR-431 expression in NSCLC. The effects of circMAT2B overexpression in NSCLC cells were abrogated by miR-431 restoration. We observed that circMAT2B was overexpressed in NSCLC tissues and cell lines, and high expression of circMAT2B was closely associated with large tumor size, advanced TNM stage and poor prognosis of NSCLC patients. Yes Further functional experiments showed that circMAT2B knockdown markedly inhibited the proliferation, migration, invasion and EMT of NSCLC cells, whereas circMAT2B overexpression led to the opposing results. 34288814 MIAT LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow,cell lines Interaction[negatively regulating miR-495] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Viability Assay In this study, we find that MIAT is overexpressed in AML patient specimens and AML cell lines.Mechanistically, we confirm that MIAT can function as a sponge to inhibit microRNA-495 (miR-495), a tumor suppressor, in AML cells. Collectively, our results demonstrate that MIAT is involved in promoting the progression of AML, at least partly, through negative regulation of miR-495, and therefore provide a promising target for treatment of AML. Importantly, upregulation of MIAT is closely related with poor clinical outcome. Yes Further investigations reveal that knockdown of MIAT inhibits the colony formation and proliferation, meanwhile, accelerates the apoptosis of AML cells in vitro. Consistently, MIAT knockdown slows AML progression in immunodeficient mice. 31698307 hsa_circ_100146 CircRNA Homo sapiens Prostatic Neoplasms PCa cells Interaction(miR-615-5p) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircRNA_100146 expression was distinctly upregulated in PCa cells. Yes Silencing of circRNA_100146 suppressed PCa cells' invasion, migration, and proliferation. CircRNA_100146 sponged miR-615-5p to suppress its expressions, while miR-615-5p targeted the 3'-UTR of TRIP13 to repress the expression of TRIP13. 34307457 MTCL1 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck paired tissues and cell line Interaction(C1QBP-β-catenin signaling axis) In Vivo Experiment//Wound Healing Assay//Co-IP//qRT-PCR//RNA-seq//IHC Specifically, circMTCL1 was remarkably up-regulated in the paired tissues of patients with LSCC (n = 67), which predicted a worse clinical outcome. Mechanistically, circMTCL1 directly recruited C1QBP protein by harboring the specific recognized sequence (+ 159 - + 210), thereby accelerating the translation of C1QBP expression by inhibiting its ubiquitin-proteasome-mediated degradation. Specifically, circMTCL1 was remarkably up-regulated in the paired tissues of patients with LSCC (n = 67), which predicted a worse clinical outcome. Yes Functionally, circMTCL1 exerted oncogenic biological charactersistics by promoting cell proliferative capability and invasive and migrative abilities. Ectopic circMTCL1 augumented cell proliferation, migration, and invasion of LSCC cells, and this effect could be reversed by C1QBP knocking down in vitro and in vivo. 35366893 NEAT1 LncRNA Homo sapiens Sepsis blood regulation[ NF-κB signaling pathway] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA The results showed that NEAT1 was highly expressed in patients with sepsis and LPS-induced H9c2 cells.Additionally, the NEAT1/miR-590-3p axis could regulate the activity of the NF-κB signaling pathway. Yes Knockdown of NEAT1 decreased LPS-induced cell apoptosis and inflammation response in H9c2 cells. 32855700 circPFKP CircRNA Homo sapiens Prostatic Neoplasms PCa tissues Interaction(IMPDH2) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//FISH//RIP//Cell Cycle Assay//EdU Staining//Transwell Assay In the present study, we found that the expression of circPFKP was significantly increased in PCa tissues compared with adjacent noncancerous prostate tissues, and was correlated with the D'Amico risk classification, N stage, and prognostic stage group of PCa. In the present study, we found that the expression of circPFKP was significantly increased in PCa tissues compared with adjacent noncancerous prostate tissues, and was correlated with the D'Amico risk classification, N stage, and prognostic stage group of PCa. Yes CircPFKP promotes the proliferation of PCa cells in vitro and in vivo. Suppressing circPFKP induced the G1/S arrest of PCa cells. Mechanistically, circPFKP interacted with IMPDH2, promoted the biogenesis of guanine nucleotides. 34673127 hsa_circ_0000418 CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-409-3p/PDK1 axis) Western Blot//Transfection//qPCR//CCK8//Flow Cytometry//RIP//Luciferase Report Assay//BrdU//Bioinformatics Analysis In this work, we observed that, circ_0000418 expression level was significantly up-regulated in glioma tissues and cell lines. Circ_0000418 specifically combined with miR-409-3p, and circ_0000418 negatively modulated the expression of miR-409-3p. PDK1 acted as a target gene of miR-409-3p, and PDK1 could be positively and indirectly modulated by circ_0000418 in glioma cells. Yes Circ_0000418 overexpression facilitated glioma cell growth and accelerated cell cycle progression, while knockdown of circ_0000418 produced the opposite effects. 35264067 hsa_circ_0006859 CircRNA Homo sapiens Osteoporosis, Postmenopausal osteoporosis patients Interaction(miR-431-5p/ROCK1) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Microarray//Bioinformatics Analysis Hsa_circ_0006859 in exosomes was upregulated in osteoporosis patients compared to healthy controls. Hsa_circ_0006859 directly bound to miR-431-5p, and ROCK1 was identified as a novel target gene of miR-431-5p. Hsa_circ_0006859 is a competing endogenous RNA (ceRNA) of miR-431-5p that promotes ROCK1 expression. Hsa_circ_0006859 suppressed osteogenesis and promoted adipogenesis by sponging miR-431-5p to upregulate ROCK1. Hsa_circ_0006859 differentiated osteopenia or osteoporosis patients from healthy controls with high sensitivity and specificity. Yes Hsa_circ_0006859 suppressed osteoblastic differentiation and promoted adipogenic differentiation of hBMSCs. 33648601 NEAT1 LncRNA Homo sapiens Sepsis kidney tissues regulation[let-7b-5p/TRAF6 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay lncRNA NEAT1 was expressed at higher levels in kidney tissues from sepsis patients than in healthy kidney tissues. Our data show that the lower expression of NEAT1 impeded sepsis development and LPS-induced injury inflammation by targeting let-7b-5p/TRAF6 axis, and NEAT1 may be a target for treatment of sepsis patients. Yes Furthermore, silencing of NEAT1 weakened LPS-induced apoptosis, inflammation, and inhibition of proliferation, which was overturned by silencing of let-7b-5p. 32724027 NEAT1 LncRNA Homo sapiens Hepatoblastoma BMSCs Interaction(miR-132/MMP9 Axis) Western Blot//Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay//IHC//Transwell Assay Differentially expressed lncRNA NEAT1/miR-132/MMP9 was obtained through bioinformatics analysis and cell verification. HB-derived exosomal lncRNA NEAT1 regulated miR-132 and MMP9 expression in BMSCs. In addition, HB-derived exosomal lncRNA NEAT1 promoted BMSCs differentiation toward invasive myofibroblast via miR-132/MMP9 axis. LncRNA NEAT1 regulated MMP9 through miR-132. Yes Tumor formation experiments in nude mice showed that HB-derived exosomal lncRNA NEAT1 could affect the development of HB. 35300348 NEAT1 LncRNA Homo sapiens Neuroblastoma neuroblastoma tissues and cell lines regulation[miR-183-5p/FOXP1,ERK/AKT Pathway] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay We observed that the expression of lncRNA nuclear-enriched abundant transcript-1 (NEAT1) was significantly decreased in human neuroblastoma tissues and cell lines, compared with the normal. Taken together, these data showed that NEAT1 negatively regulated cell proliferation and migration of neuroblastoma by the miR-183-5p/FOXP1 axis via suppression of the ERK/AKT pathway. Yes First, overexpression of NEAT1 suppressed cell proliferation and played a key role in cell migration and invasion. 32693640 NEAT1 LncRNA Homo sapiens capillary hemangioma IH tissues regulation[HIF1α/NF-κB signaling pathway] qRT-PCR//Luciferase Report Assay//Western Blot Reverse transcription?-quantitative PCR indicated that IH tissues exhibited high expression levels of NEAT1 and hypoxia?inducible factor 1α (HIF1α), and low expression levels of the microRNA (miR)?33a?5p. Collectively, the results revealed that depletion of lncRNA NEAT1 suppressed the tumorigenesis of IH by competitively binding miR‑33a‑5p and thereby stimulating the HIF1α/NF‑κB signaling pathway. Yes Small interfering RNA?mediated depletion of NEAT1 suppressed hemangioma endothelial cell (HemEC) proliferation, migration and invasion. 32945470 circSLC8A1 CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-214-5p/CDC27 axis) cell invasion assay//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay Lowly expressed circSLC8A1 was observed in both glioma tissues and cell lines. CircSLC8A1 directly sponged miR-214-5p and inhibited miR-214-5p expression in glioma cells. CDC27 was a direct target of miR-214-5p and could be regulated by miR-214-5p. Moreover, miR-214-5p mimics and CDC27 knockdown reversed the inhibitory effects of circSLC8A1 on cell proliferation and invasion. Yes Further biological analyses showed that circSLC8A1 inhibits the cell proliferation and invasion of glioma cells. 35098413 circITGA7 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(miR-370-3p) In Vivo Experiment//qRT-PCR//FISH//RNA-seq//Colony Formation Assay The present results demonstrated that circITGA7 was downregulated in PCa tissues and cells. Mechanically, circITGA7 served as a sponge for miR-370-3p, and miR-370-3p could target P21CIP1 in PCa cells. The inhibition of cell proliferation induced by circITGA7 could be reversed by transfecting miR-370-3p mimic. Yes Gain- or loss-of-function assays showed that circITGA7 inhibited the proliferation of PCa cells in vivo and in vitro. 35003259 circSMARCA5 CircRNA Homo sapiens Prostatic Neoplasms PCa cells Interaction( miR-432/PDCD10 Axis) In Vivo Experiment//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay CircSMARCA5 was aberrantly upregulated, and was a circular and stable RNA in PCa cells. MiR-432 was a direct target of circSMARCA5, and circSMARCA5 accelerated the development of PCa through miR-432 in PCa cells. PDCD10 was a direct target of miR-432, and PDCD10 addition reversed the inhibitory effects of miR-432 accumulation on the proliferation, metastasis, and glycolysis of PCa cells. Yes CircSMARCA5 accelerated the proliferation, metastasis, and glycolysis of PCa cells. 32407167 hsa_circ_0075542 CircRNA Homo sapiens Prostatic Neoplasms prostate tumor tissues Interaction(miR-1197 /HOXC11) Western Blot//Flow Cytometry//qRT-PCR//FISH//Cell Proliferation Assay The results indicated that the expression of hsa_circ_0075542 was downregulated in prostate tumor tissues. Moreover, hsa_circ_0075542 targeted the microRNA-1197 (miR-1197) homeobox C11 (HOXC11) axis by sponging miR-1197. Overexpression of miR-1197 played a tumor-promoting role. Overexpression of hsa_circ_0075542 alleviated the tumor-promoting effect of miR-1197 overexpression In conclusion, hsa_circ_0075542 suppressed malignant characteristics and promoted apoptosis in LNCaP and PC3 cells by acting as a competing endogenous RNA of miR-1197. The hsa_circ_0075542/miR-1197 axis might play a role via HOXC11. Yes The results of the functional experiments showed that overexpression of hsa_circ_0075542 suppressed cell proliferation, reduced migration and invasiveness capabilities, and promoted apoptosis. 34515615 circHIPK3 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Interaction(miR-448/MTDH signaling) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay Circular RNA circHIPK3 was significantly increased in PCa tissues and cell lines. Furthermore, circHIPK3 promoted metadherin (MTDH) expression by sponging miR-448. Yes And overexpression of circHIPK3 promoted the migration, proliferation, and invasion of PC-3 and 22Rv1 cells, while knockdown of circHIPK3 markedly repressed the above-mentioned series of biological processes. In vivo experiments, it was also found that overexpression of circHIPK3 significantly promoted tumor growth. 34142340 circMBOAT2 CircRNA Homo sapiens Pancreatic Neoplasms Pancreatic cancer tissues and cells(PANC-1 and SW1990) Expression [highly expressed] Wound Healing Assay//qPCR//MTT//Transwell Assay Circ-MBOAT2 and GOT1 expression were significantly upregulated, while miR-433-3p expression was downregulated in pancreatic cancer tissues and cells compared with normal pancreatic tissues or cells. Circ-MBOAT2 silencing repressed cell proliferation, migration, invasion and glutamine catabolism, whereas promoted cell apoptosis in pancreatic cancer. Additionally, circ-MBOAT2 acted as a sponge of miR-433-3p, which was found to be associate with GOT1. Yes Circ-MBOAT2 silencing repressed cell proliferation, migration, invasion and glutamine catabolism, whereas promoted cell apoptosis in pancreatic cancer. 33832516 NEAT1 LncRNA Homo sapiens Hodgkin Disease HL tissues and cell lines regulation[miR-448,DCLK1 ] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay QRT-PCR results showed that NEAT1 expressed higher in HL tissues and cell lines than that in controls. NEAT1 might be contributed to HL progression by promoting cell proliferation and invasion capability via miR-448 mediated DCLK1 expression. Yes In vitro experiments, NEAT1 downregulation could decrease cell proliferation and invasion capability in L428 cells. 32572888 hsa_circ_0001666 CircRNA Homo sapiens Pancreatic Neoplasms PC tissues and PC cell lines Interaction(miR-1251) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay We found that circ_0001666 is highly expressed in PC tissues and PC cell lines.Moreover, circ_0001666 is able to bind to miR-1251, thus increasing the expression of SOX4, which is a direct downstream effector of miR-1251. Patients with high circ_0001666 expression had shorter survival times. Yes In vitro and in vivo experiments have demonstrated that upregulation of circ_0001666 facilitates PC cell proliferation, EMT and invasiveness, whereas knockdown of circ_0001666 exhibits opposite functions. 34055896 MBNL1-AS1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Interaction(miR-181a-5p and PTEN/PI3K/AKT/mTOR signaling) RNA Pull-Down//Western Blot//Wound Healing Assay//RIP//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Results indicated that MBNL1-AS1 was conspicuously downregulated while miR-181a-5p upregulating in PCa tissues and cell lines.Further study revealed that MBNL1-AS1 acted as a sponge for miR-181a-5p and positively regulated PTEN by a sponge effect. Furthermore, miR-181a-5p overexpression counteracted the expression of PTEN and proteins in PI3K/AKT/mTOR signaling exerted by MBNL1-AS1-upregulation in PCa cells. Yes MBNL1-AS1 overexpression decreased the abilities of cell proliferation, invasion, and migration. 33648424 circANKS1B CircRNA Homo sapiens Prostatic Neoplasms PC cells and tissues Interaction(miR-152-3p/TGF-α) Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay The expression of circANKS1B was markedly upregulated in both PC cells and tissues.Dual-luciferase reporter assay indicated that circANKS1B directly bound to miR-152-3p.Furthermore, circANKS1B negatively regulated miR-152-3p expression.In addition, the impact of miR-152-3p silencing on invasion of circANKS1B-deficient PC cells was also abrogated by TGF-α deficiency. Moreover, high circANKS1B expression was associated with poor prognosis in PC patients. Yes Knockdown of circANKS1B markedly suppressed cell migration and invasion and TGF-α expression in PC cells, whereas the effects of circANKS1B silencing were reversed by miR-152-3p deficiency. 33556191 circPAPPA CircRNA Homo sapiens Prostatic Neoplasms PCa tissues (n = 35), the para-cancer normal tissues (n = 35) Interaction(miR-515-5p/FKBP1A axis) In Vivo Experiment//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay Circ-PAPPA abundance was markedly enhanced in PCa. Circ-PAPPA negatively regulated microRNA-515-5p (miR-515-5p) abundance. Yes Circ-PAPPA interference restrained cell viability, proliferation, motility and glycolysis while elevated the apoptosis rate of PCa cells. 34469009 hsa_circ_0062019 CircRNA Homo sapiens Prostatic Neoplasms Pca tissues Interaction(miR-1253/NRBP1 axis) In Vivo Experiment//IHC//Western Blot//Tube Formation Assay//qPCR//CCK8//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay As a result, circ_0062019 and NRBP1 were increased, but miR-1253 was decreased in PCa. Simultaneously, miR-1253 hindered PCa cell progression via regulating NRBP1. Yes Depletion of circ_0062019 curbed cell proliferation, migration, invasion, angiogenesis and EMT and induced apoptosis in PCa cells. Circ_0062019 facilitated the malignancy of PCa cells via sequestering miR-1253. 34866220 circLRP6 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(miR-330-5p/NRBP1) In Vivo Experiment//RNA Pull-Down//cell invasion assay//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//IHC CircLRP6 was highly expressed in PCa tissues and cells, knockdown of circLRP6 impaired PCa cell growth and metastasis in vitro by affecting cell proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition (EMT). Mechanistic studies showed that circLRP6 could competitively bind with miR-330-5p to prevent the degradation of its target gene NRBP1. Rescue assay suggested that miR-330-5p inhibition reversed the inhibitory effects of circLRP6 knockdown on PCa cell growth and metastasis. Moreover, overexpression of miR-330-5p suppressed PCa progression via NRBP1. Yes CircLRP6 was highly expressed in PCa tissues and cells, knockdown of circLRP6 impaired PCa cell growth and metastasis in vitro by affecting cell proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition (EMT). Notably, tumor formation assay indicated that circLRP6 silencing impeded tumor growth and EMT in vivo. 34158077 circPRKCI CircRNA Homo sapiens Prostatic Neoplasms PCa tissues Interaction(miR-24-3p ) qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Transwell Assay Circ_PRKCI was upregulated in PCa tissues than adjacent normal ones. As the downstream target of circ_PRKCI, miR-24-3p was negatively regulated by it. Moreover, circ_PRKCI/miR-24-3p axis was responsible for triggering proliferative and metastatic potentials in PCa. PCa patients expressing a high level of circ_PRKCI had high risks of lymphatic metastasis and distant metastasis. Yes Knockdown of circ_PRKCI weakened proliferative and metastatic abilities of PCa cells. 34268958 MIAT LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Interaction[upregulating LASP1] qRT-PCR Through analysis of RNA sequencing, we observed that lncRNA-MIAT was overexpressed in PTC tissues. The upregulation of MIAT was further confirmed in 40 pairs of PTC tissues and normal tissues we collected. Mechanistically, MIAT directly bound to miR-324-3p and upregulated LASP1 expression in PTC cells. In addition, expression of MIAT was positively correlated with LASP1 mRNA expression in samples collected from patients with PTC. More importantly, transfection of recombinant LASP1 attenuated MIAT silencing induced inhibition of cell proliferation, invasion and disruption of cell cycle progression in PTC cells. Yes In the function assays, results suggested that MIAT silencing led to inhibition of cell proliferation, invasion and disruption of cell cycle progression in PTC cells. 31372094 MIAT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines regulation[MIAT/miR-139-5p/MMP2 axis] qRT-PCR//Transwell Assay//Western Blot In this study, MIAT, miR-139-5p and MMP2 expression were measured by quantitative reverse transcriptase PCR (QRT-PCR) or Western blotting, respectively, and we found the expression of MIAT and MMP2 were elevated, while miR-139-5p was decreased in NSCLC tissues and cell lines.In conclusion, our results demonstrated that lncRNA MIAT modulated the migration and invasion of NSCLC by regulating miR-139-5p and MMP2. Yes Transwell assay showed MIAT and MMP2 functioned as an oncogene to induce cell migration and invasion in NSCLC, but miR-139-5p served as a tumor suppressor in NSCLC to inhibit cell migration and invasion. Besides that, in vivo experiments also indicated MIAT deletion inhibited tumor growth. 32345777 hsa_circ_0074032 CircRNA Homo sapiens Prostatic Neoplasms Pca tissues Interaction(microRNA-198 /HOXA1) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0074032 was overexpressed in PCa, and high circ_0074032 level was associated with worse PCa-related prognosis. Furthermore, circ_0074032 was identified as a miR-198 decoy, and miR-198 inhibition abolished circ_0074032 silencing-mediated effects on PCa cell proliferation, apoptosis, migration and invasion. In addition, miR-198 directly targeted homeobox A1 (HOXA1), and HOXA1 weakened miR-198 mimic-mediated impacts on PCa cell malignant phenotypes. Importantly, circ_0074032 regulated HOXA1 expression by sponging miR-198. Circ_0074032 was overexpressed in PCa, and high circ_0074032 level was associated with worse PCa-related prognosis. Yes Functionally, circ_0074032 silencing decreased xenograft tumour growth in vivo and induced cell apoptosis, curbed cell proliferation, migration and invasion in PCa cells in vitro. 34799875 MBNL1-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder tissue Regulation[miR-135a-5p/PHLPP2/FOXO1 axis ] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Microarray//BrdU//IHC The results showed that MBNL1-AS1 was significantly downregulated in bladder tumor tissues, and associated with BC progression.In conclusion, this study firstly suggests that MBNL1-AS1 acts as a tumor suppressor of BC by targeting miR-135a/PHLPP2/FOXO1 axis, providing a novel insight for BC diagnosis and treatment. Yes In vitro, MBNL1-AS1 knockdown increased the number of viable cells and bromodeoxyuridine-positive cells, accelerated cell cycle, and dysregulated proliferative regulators (Ki67, p21, p27, and Cyclin D1) in BC cells. Overexpression of MBNL1-AS1 had opposite effects on BC cell proliferation and apoptosis. 31769229 circSOBP CircRNA Homo sapiens Prostatic Neoplasms PCa specimens Interaction(miR-141-3p/MYPT1/p-MLC2 axis) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//IF We observed that circSOBP level was significantly lower in PCa specimens compared with adjacent noncancerous prostate specimens, and was correlated with the grade group of PCa. Mechanistically, circSOBP bound miR-141-3p and regulated the MYPT1/p-MLC2 axis. Yes Overexpression of circSOBP suppressed PCa migration and invasion in vitro and metastasis in vivo. CircSOBP depletion increased migration and invasion and induced amoeboid migration of PCa cells. 33784000 hsa_circ_0062019 CircRNA Homo sapiens Prostatic Neoplasms PCa cell lines Interaction(miR-195-5p/HMGA2 axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our results showed that hsa_circ_0062019 was highly expressed in PCa cell lines. Furthermore, luciferase reporter assay proved the binding of hsa_circ_0062019 with miR-195-5p and the binding between miR-195-5p and high mobility group AT-hook 2 (HMGA2), suggesting that hsa_circ_0062019 promoted the expression of HMGA2 by sponging miR-195-5p. Yes Cell Counting Kit-8 assay revealed that upregulation of hsa_circ_0062019 boosted PCa cell proliferation, and silencing of hsa_circ_0062019 inhibited cell proliferation. Meanwhile, transwell assay proved that upregulation of hsa_circ_0062019 facilitated PCa cell invasion and migration, while downregulation of hsa_circ_0062019 inhibited these malignant phenotypes. 33978716 hsa_circ_0006404 CircRNA Homo sapiens Prostatic Neoplasms 30 pairs of PCa tissues and adjacent normal tissues Interaction(miR-1299/CFL2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Circ_0006404 level was notably elevated in PCa. Circ_0006404 directly targeted miR-1299, and miR-1299 silencing largely reversed circ_0006404 interference-induced influences in PCa cells. CFL2 directly bound to miR-1299, and miR-1299-induced effects in PCa cells were largely attenuated by CFL2 overexpression. Yes Circ_0006404 contributed to the viability, metastasis and proliferation and impaired the apoptosis of PCa cells.  33442268 MIR503HG LncRNA Homo sapiens Ovarian Neoplasms ovarian tumor tissues and cells Interaction(MAPK/PI3K/AKT pathways) qRT-PCR//RNA Pull-Down//RIP//ChIP In this study, lower expressed MIR503HG was observed in ovarian tumor tissues and cells than in adjacent normal tissues and normal human ovarian epithelial cells. Nuclear and cytoplasmic separation test suggested that MIR503HG was mainly expressed in the nucleus. RNA immunoprecipitation and RNA pull-down assays confirmed that MIR503HG could bind to transcription factor SPI1 (Spi-1 proto-oncogene), and dual luciferase reporter gene and Chromatin immunoprecipitation assays verified that SPI1 could bind to TMEFF1 (Transmembrane protein with EGF like and two follistatin like domains 1) promoter, suggesting that MIR503HG suppressed TMEFF1 expression by competitively binding SPI1 and blocking transcriptional activation of TMEFF1. Yes MIR503HG overexpression impaired the proliferative, invasive and EMT properties, and facilitated cell apoptosis in ovarian cancer cells. 35771155 NEAT1 LncRNA Homo sapiens capillary hemangioma IH tissues and cells Interaction(miR-378b/FOSL1 axis) In Vivo Experiment//Western Blot//MeRIP//Transfection//Migration Assay//CCK8//RIP//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Invasion Assay//Transwell Assay ALKBH5, lncRNA NEAT1 and FOLS1 expression was elevated in IH tissues, while miR-378b was downregulated.ALKBH5 might have great potential as therapeutic target for IH, since ALKBH5 silencing suppressed IH progression by regulation of the NEAT1/miR-378b/FOSL1 axis. Yes In addition, miR-378b was the target of lncRNA NEAT1, and its overexpression reversed the promotion effect of lncRNA NEAT1 overexpression on IH cell tumor-like behaviors. Moreover, FOLS1 was the target of miR-378b, and its overexpression reversed the inhibitory effect of miR-378b overexpression on IH cell tumor-like behaviors in vitro. 35182329 NEAT1 LncRNA Homo sapiens Laryngeal Neoplasms laryngocarcinoma tissues and cell lines Interaction[targeting miR-29a-3p] qRT-PCR NEAT1 was upregulated in laryngocarcinoma tissues and cell lines. Further experiments showed that miR-29a-3p was directly targeted by NEAT1, and participated in NEAT-mediated progression of laryngocarcinoma. Yes NEAT1 knockdown suppressed growth and invasive abilities in laryngocarcinoma cells, while overexpression of NEAT1 enhanced such abilities. 31364125 MIR503HG LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues and cell lines regulation[miR-107/Par4 axis] RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Transwell Assay The expression of MIR503HG was decreased in colon cancer tissues and cell lines.MIR503HG regulated Par4 via sponging miR-107 in colon cancer, which promoting a new idea for the treatment of colon cancer. Yes MIR503HG overexpression inhibited cell proliferation, migration and invasion, promoted cell apoptosis, down-regulated N-cadherin and Vimentin, and up-regulated E-cadherin in colon cancer. 32738347 MIR503HG LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-503-5p/KANK1 axis) Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay H19X was remarkably up-regulated in CRC tissues. Through a number of functional studies, we found that H19X silencing inhibited the malignance phenotype of cancer cells through loss of miR-503-5p. Further studies demonstrated that miR-503-5p was involved in the progression of CRC by directly regulating the downstream target KANK1. Its expression related to tumor size (p = 0.041), lymph node metastasis (p = 0.037), distal metastasis (p = 0.028), advanced TNM stage (p = 0.034) and poor survival in CRC. Yes H19X acted as an oncogenic lncRNA that induced CRC cell proliferation, invasion and metastasis. T 35567714 NEAT1 LncRNA Homo sapiens Endometriosis EM tissues and cells Interaction(miR-124-3p) Western Blot//Flow Cytometry//MTT//H&E Staining//Transwell Assay MiR-124-3p was identified as a target of NEAT1, and could be negatively regulated by NEAT1 in EC-ESCs. The expression level of NEAT1 was evidently increased, whereas that of miR-124-3p was decreased, in the EM in vivo model, EM tissues and EC-ESCs from patients with EM. The loss-of-function assays further established that silencing of NEAT1 could inhibit EC-ESC proliferation, migration, and invasion, but it led to the promotion of apoptosis via targeting miR-124-3p. Yes The loss-of-function assays further established that silencing of NEAT1 could inhibit EC-ESC proliferation, migration, and invasion, but it led to the promotion of apoptosis via targeting miR-124-3p. 35094286 circβ-catenin CircRNA Homo sapiens Gallbladder Neoplasms GBC tissues Interaction(circβ-catenin/miR-223/STMN1 axis ) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//IHC//Bioinformatics Analysis In the study, we first demonstrated that circular RNA circβ-catenin expression was upregulated in GBC tissues when compared to adjacent normal tissues and associated with advanced clinical stage and poor prognosis in GBC patients.Mechanistic analysis further highlighted that circβ-catenin promoted Stathmin 1 (STMN1) expression through sponging miR-223 in GBC progression. In addition, knockdown of STMN1 inhibited cell growth and Warburg effect in GBC. In the study, we first demonstrated that circular RNA circβ-catenin expression was upregulated in GBC tissues when compared to adjacent normal tissues and associated with advanced clinical stage and poor prognosis in GBC patients. Yes Silencing of circβ-catenin obviously suppressed GBC cell proliferation and cell cycle progression in vitro, but circβ-catenin overexpression had the opposite effects. In vivo, silencing of circβ-catenin inhibited tumor growth. . Furthermore, we also found that circβ-catenin promoted GBC cell lactate production, pyruvate production, ATP quantity, and extracellular acidification rate (ECAR), which suggested that circβ-catenin regulated Warburg effect in GBC. 34489401 NEAT1 LncRNA Homo sapiens Arthritis, Rheumatoid synovial tissues regulation[miR-410-3p/YY1 Axis] Flow Cytometry//qRT-PCR//Luciferase Report Assay We found that NEAT1 was upregulated in synovial tissues and FLSs in RA. Inhibiting miR-410-3p and upregulating YY1 partially restored the inhibitory role in cell viability induced by the depletion of NEAT1 in RA FLSs. Yes Upregulation of NEAT1 promoted cell proliferation, induced S-to G2/M phase transition, and suppressed apoptosis in RA FLSs. 32983133 MBNL1-AS1 LncRNA Mus musculus acute myocardial infarction AMI model Interaction(miR-132-3p/SOX4 ) qRT-PCR//MTT//Luciferase Report Assay//Western Blot AMI model was constructed using Wistar rats and it was found that LncRNA MBNL1-AS1 was upregulated in AMI model according to the quantitative real-time polymerase chain reaction (qRT-PCR) results. Furthermore, Targetscan database predicted that SRY-related high-mobility-group box 4 (SOX4) was the direct target of miR-132-3p and was regulated by MBNL1-AS1 through miR-132-3p. Moreover, overexpression of SOX4 partially eliminated effects of MBNL1-AS1 on myocardial cells. Yes The left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP) and maximum rate of rise/fall of left ventricle pressure (±dp/dt max) were detected through hemodynamics test, which showed that knockdown of MBNL1-AS1 improved cardiac function in AMI model. The results revealed that silencing MBLN1-AS1 alleviated myocardial injury in AMI model. Additionally, MBNL1-AS1 knockdown inhibited apoptosis of myocardial cells and reduced the expression of apoptotic proteins. According to DIANA database and luciferase reporter assay, miR-132-3p was the direct target of MBNL1-AS1 and was negatively regulated by MBNL1-AS1. 34978261 circSMAD2 CircRNA Homo sapiens Gallbladder Neoplasms GBC cells Interaction(eIF4A3/SMAD2) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Cell Apoptosis Assay//Transwell Assay The data revealed that circSMAD2 was upregulated in GBC, and circSMAD2 knockdown significantly inhibited the viability of GBC cells. Meanwhile, circSMAD2 suppressed the binding between eukaryotic translation initiation factor 4A3 (eIF4A3) and SMAD2 through binding with eIF4A3. Knockdown of circSMAD2 notably inhibited the expression of SMAD2 in GBC cells, and SMAD2 overexpression partially reversed the anti-tumor effect of circSMAD2 knockdown. Yes The data revealed that circSMAD2 was upregulated in GBC, and circSMAD2 knockdown significantly inhibited the viability of GBC cells. In addition, circSMAD2 siRNA notably induced the apoptosis in GBC cells. The migration and invasion of GBC cells were obviously suppressed in the presence of circSMAD2 siRNA. 34727877 NEAT1 LncRNA Homo sapiens Arthritis, Rheumatoid FLSs Interaction(miR-338-3p/GLS ) RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay NEAT1 was significantly upregulated, and miR-338-3p was significantly downregulated in FLSs from RA patients compared to normal FLSs.Bioinformatics analysis showed that NEAT1 sponges miR-338-3p to form competing endogenous RNA (ceRNAs), which was verified by RNA pull-down assay and luciferase assay FLSs-RA had an increased rate of glutamine metabolism compared to normal FLSs increased compared to normal FLSs. The results confirmed that GLS (Glutaminase), a key enzyme in glutamine metabolism, is a direct target of miR-338-3p in FLSs-RA. Yes Silencing of NEAT1 and overexpression of miR-338-3p suppressed glutamine metabolism in FLSs-RA and promoted H2O2-induced apoptosis. 36050752 circTP63 CircRNA Homo sapiens Gallbladder Neoplasms GBC tissues and cells Interaction( miR-217 /EZH2) In Vivo Experiment//Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Invasion Assay In the present study, we showed that circTP63 expression was upregulated in GBC tissues and cells. Mechanistically, we demonstrated that circTP63 competitively bind to miR-217 and promoted EZH2 expression and finally facilitated tumor progression. Higher circTP63 expression was associated with lymph node metastasis and short overall survival (OS) in patients with GBC. Yes In vitro, knockdown of circTP63 significantly inhibited cell proliferation, cell cycle progression, migration and invasion abilities in GBC. 34789260 MIAT LncRNA Homo sapiens Thyroid Neoplasms PTC Interaction(miR-150/EZH2 pathway) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis Besides, significant differences in MIAT/EZH2 expression were found among various clinicopathological features. Moreover, EZH2 was identified as a direct downstream target of miR-150-5p in PTC cells. Restoration of EZH2 expression partially abolished the biological effects of miR-150-5p. Yes Gain- and loss-of-function experiments revealed that MIAT inhibited cell proliferation and migration in vitro. 34811354 MBNL1-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction(miR-889-3p/KLF9 axis) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Colony Formation Assay//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay The expression of the lncRNA MBNL1-AS1 was low in the breast cancer tissues and cells.The lncRNA MBNL1-AS1 could interact with miR-889-3p, and KLF9 was the downstream target of miR-889-3p. Moreover, miR-889-3p was negatively correlated with KLF9 and lncRNA MBNL1-AS1. Both miR-889-3p and si-KLF9 could reverse the overexpression of lncRNA MBNL1-AS1 in breast cancer development. The lncRNA MBNL1-AS1 decreased proliferation, invasion, migration and glycolysis of breast cancer via the miR-889-3p/KLF9 axis, which might be a potential biomarker for the diagnosis of breast cancer. Lower expression levels of the lncRNA MBNL1-AS1 were associated with poor prognosis of breast cancer. Yes Overexpression of the lncRNA MBNL1-AS1 decreased proliferation, invasion, migration and glycolysis of breast cancer cells. 35112997 MBNL1-AS1 LncRNA Homo sapiens Prostatic Neoplasms tissues and cells Interaction(miR-221-3p/CDKN1B/C-myc Axis) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay MBNL1-AS1 was shown to be negatively correlated with stemness index (mRNAsi), and even prognosis, tumor progression, recurrence, and drug resistance in PC patients. Molecular mechanism studies suggested that MBNL1-AS1 regulates CDKN1B through competitive binding to miR-221-3p, which led to the inhibition of the Wnt signaling pathway to affect PCSCs. MBNL1-AS1 was shown to be negatively correlated with stemness index (mRNAsi), and even prognosis, tumor progression, recurrence, and drug resistance in PC patients. Yes The knockdown of MBNL1-AS1 significantly affected the stemness of the PC cells, and subsequently their invasive and proliferative abilities. 36497267 MIAT LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues, cell lines Interaction[sponging miR-212] CCK8//Wound Healing Assay//Transwell Assay We found that MIAT was Expression[Expression[up-expression]-expression]-regulated in PTC tissues and cell lines. Luciferase assays further confirmed that miR-212 interacts with MIAT. Additionally, the negatively correlation of miR-212 with MIAT was verified in patients' samples. Repression of miR-212 partly abrogated the inhibitory effects of MIAT knockExpression[down-expression] on PTC cells. High MIAT expression was positively associated with advanced tumor-node-metastasis (TNM) stage and lymph node metastasis. Yes Functional assays showed that knockExpression[down-expression] of MIAT in PTC cells significantly inhibited cell proliferation, colony formation, migration and invasion in vitro, as well as impaired tumor growth in vivo. 31404776 hsa_circ_0079593 CircRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-324-5p/XBP1 axis) In Vivo Experiment//Western Blot//Transfection//Tube Formation Assay//qPCR//CCK8//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0079593 and XBP1 levels were elevated, while miR-324-5p level was declined in glioma. Circ_0079593 accelerated glioma progression via sequestering miR-324-5p, one of the targets of circ_0079593. XBP1 was a target gene of miR-324-5p, and miR-324-5p alleviated the malignant growth of glioma by repressing XBP1. Circ_0079593 contributed to the malignant evolution of glioma via modulating miR-324-5p and downstream XBP1 gene, suggesting that circ_0079593 might be a promising therapeutic target for glioma. Yes Silencing of circ_0079593 restrained proliferation, mobility, angiogenesis and glycolysis and induced apoptosis in glioma cells. Furthermore, silence of circ_0079593 hindered tumor growth in vivo. 35793013 MAPKAPK5-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissues and cells Interaction(miR-490-3p/HMGB2) CCK8//qRT-PCR//Flow Cytometry//In Vivo Experiment The expression of MAPKAPK5-AS1 was upregulated in tumor tissues from NSCLC patients. Mechanically, MAPKAPK5-AS1 could upregulate the HMGB2 level in NSCLC cells through competitively binding to miR-490-3p. MiR-490-3p inhibitor reversed the roles of MAPKAPK5-AS1 knockdown on tumor cell proliferation, apoptosis and EMT. Also, HMGB2 knockdown suppressed tumor cell malignant phenotypes. Patients with high expression of MAPKAPK5-AS1 had higher tumor size, advanced TNM stage, higher incidence of lymph node and distant metastasis, and shorter overall survival. Yes Knockdown of MAPKAPK5-AS1 inhibited the proliferation, induced apoptosis and blocked epithelial mesenchymal transformation (EMT) of NSCLC cells. Furthermore, interference of MAPKAPK5-AS1 slowed NSCLC tumor growth in vivo. 36445573 MILIP LncRNA Homo sapiens gastric adenocarcinoma GA tissues Interaction(miR-505 /PLK1 ) CCK8//qRT-PCR//Luciferase Report Assay//Western Blot The results indicated that MAFG-AS1 was highly expressed in GA and closely correlated with poor survival. MAFG-AS1 interacted with miR-505, but MAFG-AS1 and miR-505 overexpression showed no significant effects on each other's expression. In addition, MAFG-AS1 increased the expression of PLK1, a miR-505 target. The results indicated that MAFG-AS1 was highly expressed in GA and closely correlated with poor survival. Yes MAFG-AS1 and PLK1 overexpression increased GC cell proliferation rate. MiR-505 overexpression reduced the effects of MAFG-AS1 and PLK1 overexpression on cell proliferation. 34591387 NEAT1 LncRNA Homo sapiens Thyroid Neoplasms ATC tissues and cells regulation[miR-206 and miR-599] qRT-PCR//Luciferase Report Assay//RIP Our data indicated that NEAT1 was highly expressed in ATC tissues and cells, and hypoxia induced NEAT1 expression in ATC cells.In conclusion, our study suggested that a low NEAT1 expression suppressed the migration, invasion, and glycolysis in ATC cells under hypoxia at least partially through modulating miR-206 and miR-599, providing new therapeutic strategies for ATC treatment. Yes NEAT1 depletion repressed ATC cell migration, invasion and glycolysis under hypoxia. 32336952 circRFX3 CircRNA Homo sapiens Glioma glioma cells Interaction(HNRNPK/RFX3 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//IHC//EdU Staining//ChIP CircRFX3 was highly expressed in glioma cells. Mechanism analyses suggested that circRFX3 recruited HNRNPK to enhance RFX3 mRNA stability, thereby facilitating glioma cell malignant behaviors. RFX3 was also unveiled to affect glioma cells via stimulating PROX1 transcription. Yes CircRFX3 knockdown led to the suppression of glioma cell and tumor growth. CircRFX3 overexpression resulted in the opposite outcomes. 35416616 hsa_circ_0000069 CircRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues and cell lines Expression[highly expressed] qRT-PCR The expression of hsa_circ_0000069 was markedly upregulated in pancreatic cancer tissues and cell lines. SCL/TAL1 interrupting locus (STIL) is the parent gene for hsa_circ_0000069, and its high expression was related to poor overall survival in patients with pancreatic cancer. Yes In addition, downregulation of hsa_circ_0000069 markedly suppressed STIL expression, induced the apoptosis and cell cycle arrest, and inhibited the proliferation, migration and invasion in pancreatic cancer cells. Moreover, hsa_circ_0000069 knockdown inhibited the growth of xenograft pancreatic cancer tumors in vivo. 33324055 NEAT1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Interaction(lncRNA NEAT1/miRNA-766-5p/E2F3) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay Here, we find that NEAT1 is overexpressed in PCa tissues and cell lines. Further mechanistic studies find that NEAT1 sponges miR-766-5p, and miRNA-766-5p is negatively correlated with the expression of NEAT1. In addition, the functional experiment shows that upregulation of miRNA-766-5p inhibits PCa proliferation, migration, and invasion. Furthermore, E2F transcription factor 3 (E2F3) is testified to be the downstream target gene of miRNA-766-5p. Finally, the rescue experiment revealed that miRNA-766-5p inhibition largely restores NEAT1 downregulation-mediated function on PCa progression, while E2F3 knockdown partly removes the effects of miRNA-766-5p inhibitor. Yes Besides, silencing of NEAT1 inhibits cell proliferation, invasion, and migration and promotes cell apoptosis and cell cycle arrest. 35237319 hsa_circ_0030042 CircRNA Homo sapiens Atherosclerosis HUVECs Interaction(Eif4a3) FISH//Transfection//IHC//RIP hsa_circ_0030042 was significantly downregulated in CHD, while upon overexpression, it acted as an endogenous eukaryotic initiation factor 4A-III (eIF4A3) sponge to inhibit ox-LDL-induced abnormal autophagy of HUVECs and maintain plaque stability in vivo. Furthermore, hsa_circ_0030042 influenced autophagy by sponging eIF4A3 and blocking its recruitment to beclin1 and forkhead box O1 (FOXO1) mRNA, while hsa_circ_0030042-induced inhibition of beclin1 and FOXO1 was counteracted by eIF4A3 overexpression or decreased hsa_circ_0030042 binding. Yes Furthermore, hsa_circ_0030042 influenced autophagy by sponging eIF4A3 and blocking its recruitment to beclin1 and forkhead box O1 (FOXO1) mRNA, while hsa_circ_0030042-induced inhibition of beclin1 and FOXO1 was counteracted by eIF4A3 overexpression or decreased hsa_circ_0030042 binding. In high-fat-diet fed ApoE-/- mice, hsa_circ_0030042 also ameliorated plaque stability and counteracted eIF4A3-induced plaque instability. 33859754 hsa_circ_102541 CircRNA Homo sapiens Atherosclerosis atherosclerosis specimens Interaction(miR-296-5p/PLK1 pathway) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Bioinformatics Analysis The expression of circRNA_102541 and PLK1 were significantly elevated in atherosclerosis specimens, where the level of miR-296-5p was reduced. Furthermore, circRNA_102541 could bind miR-296-5p and subsequently target PLK1. Yes Following treatment with sh-circRNA_102541 or miR-296-5p mimics, proliferative ability and levels of PCNA were remarkably reduced in HUVEC cells, while apoptosis was significantly enhanced. 34251586 MT1JP LncRNA Homo sapiens Breast Neoplasms breast cells regulation[regulating miR-92-3p] CCK8//qRT-PCR//Transwell Assay The results demonstrated that MT1JP was significantly down-regulated in breast cells. Our data indicate that MT1JP functions as an anti-tumor LncRNA and downregulates miR-92-3p, CD151 and CD147, and may serve as a novel diagnostic and therapeutic marker in breast cancer. Yes Additionally, we found that overexpression of MT1JP in breast cancer cells significantly inhibited cell proliferation, migration and invasion, and regulate the expression of CDK2, cyclinE1 and P21. 32039825 circAGFG1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung non-small-cell lung cancer tissues Regulation[circAGFG1/miR-203/ZNF281 axis ] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Our results revealed that expression levels of circAGFG1 and miR-203 are upregulated in non-small-cell lung cancer tissues. In conclusion, our study suggests that circAGFG1 promotes NSCLC growth and metastasis though a circAGFG1/miR-203/ZNF281 axis and may represent a novel therapeutic target. Yes CircAGFG1 enhances NSCLC cell proliferation, invasion, migration and epithelial-mesenchymal transition in vitro. 31243884 hsa_circ_0062389 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue and cell lines Regulation[hsa_circ_0062389/miR-103a-3p/CCNE1 axis] CCK8//qRT-PCR//Luciferase Report Assay In the present study, hsa_circ_0062389 expression was significantly increased in NSCLC tissues and cell lines. In mechanism, hsa_circ_0062389 directly interacted with miR-103a-3p in NSCLC, and CCNE1 acted as a target of miR-103a-3p. Furthermore, rescue assays showed that miR-103a-3p suppression or CCNE1 overexpression abolished the effects of hsa_circ_0062389 suppression on lung cancer cells progression. Therefore, our results showed that the hsa_circ_0062389/miR-103a-3p/CCNE1 axis might contribute to the tumorigenesis of NSCLC, which provided a new strategy for cancer treatment. High hsa_circ_0062389 expression was associated with advanced TNM stage and lymph-node metastasis. Yes Function assays showed that hsa_circ_0062389 suppression reduced NSCLC cells proliferation and arrested cell cycle in G0/G1 phase.  31962276 MIF-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues ,cell lines Regulation[miR-1249-3p/HOXB8 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay qRT-PCR showed that MIF-AS1 was Expression[up-expression]regulated in BC tissues and cells.Using bioinformatics analysis and luciferase reporter assay, we identified that MIF-AS1 regulated the level of Homeobox B8 (HOXB8) via binding to miR-1249-3p. Yes Thereafter, we found that MIF-AS1 depletion inhibited BC cell proliferation, migration and epithelial-mesenchymal transition (EMT). 31097355 MT1JP LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues regulation[RUNX3] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Transwell Assay The expression of MT1JP was downregulated in HCC tumor tissues compared with that in adjacent normal tissues, while the percent survival was significantly greater in the high MT1JP expression group than in the low MT1JP expression group (P=0.0238).Overexpression of MT1JP suppressed HCC cell biological activities through the regulation of RUNX3. Yes In vitro, overexpression of MT1JP suppressed the proliferation, invasion, and migration, reduced colony cell number, increased cell apoptosis, and induced G1-phase cell cycle arrest in Bel-7402 and Huh-7 cells. 32943929 MIF-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines regulation[MIF-AS1/miRNA-31-5p/PLCB1 ] qRT-PCR//Luciferase Report Assay//Western Blot MIF-AS1 was significantly upregulated in OC tissues and cell lines (p<0.05).Furthermore, the regulatory loop MIF-AS1/miRNA-31-5p/PLCB1 could be utilized as a therapeutic target for OC. Higher level of MIF-AS1 predicted significantly worse prognosis of OC patients (p<0.05). Yes The knockdown of MIF-AS1 markedly attenuated the proliferative, migratory, and invasive abilities of ES-2 and HO-8910 cells (p<0.05). 32196575 circCHFR CircRNA Homo sapiens Atherosclerosis serums regulation[miR-214-3p/Wnt3/β-catenin pathway] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//ELISA Circ_CHFR was up-regulated in AS serums and ox-LDL-stimulated VSMCs.Circ_CHFR contributed to the progression of AS through the miR-214-3p/Wnt3/β-catenin signals, which illuminated the molecular mechanism of AS and suggested circ_CHFR might be an index for AS treatment. Yes Circ_CHFR depletion weakened the ox-LDL-induced promotion of cell growth, migration and inflammation in VSMCs. 32271446 MIAT LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[miR-331-3p/RAB5B pathway] Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay The results indicated that MIAT levels were significantly upregulated in GC tissues and cells, correlated with RAB5B levels and inversely associated with miR-331-3p levels.These data suggest that MIAT promotes GC progression via modulating miR-331-3p/RAB5B pathway. Yes MIAT overexpression promoted proliferation and metastasis, and inhibited the apoptosis of GC cells. MIAT knockdown had the opposite effect on GC cells. 33154765 hsa_circ_0003645 CircRNA Homo sapiens Atherosclerosis AS tissues regulation[NF-κB pathway,oxLDL] CCK8//qRT-PCR//ELISA//Western Blot Circ_0003645 was found up-regulated in AS patients and in HUVECs treated with oxLDL. In conclusion, circ_0003645 silencing alleviated inflammation and apoptosis, while promoted the viability in oxLDL-induced endothelial cells by the NF-κB pathway. Yes The LDH leakage, cell apoptosis, and expression levels of IL-6, TNF-α, ICAM-1, VCAM-1, NF-κB mRNA, NF-κB protein were all inhibited by circ_0003645 silencing, while cell viability was promoted, and the opposite effects were observed by the overexpression of circ_0003645. 32554046 hsa_circ_0008344 CircRNA Homo sapiens Glioblastoma IDH1 wild-type glioblastoma,and cells Expression [highly expressed] qRT-PCR//MTT//Cell Apoptosis Assay//Microarray//Colony Formation Assay//Transwell Assay CircRNA microarray revealed a total of 417 abnormally expressed circRNAs (>1.5-fold, P < .05) in glioblastoma tissue compared with the adjacent normal brain. Hsa_circ_0008344, among the top differentially expressed circRNAs, was significantly upregulated in IDH1 wild-type glioblastoma. Yes Further in vitro studies showed that knockdown of hsa_circ_0008344 suppressed glioblastoma cell proliferation, colony formation, migration, and invasion, but increased cell apoptotic rate. 29687495 circBFAR CircRNA Homo sapiens Glioblastoma GBM tissues or cell lines Interaction(miR-548b/FoxM1 axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//RNA-seq//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay In this study, the expression of circBFAR was significantly increased both in GBM tissues or cell lines and was negatively correlated with overall survival in patients with GBM.In conclusion, the present study demonstrated that a circBFAR/miR-548b/FoxM1 axis regulates the development of GBM and highlights potentially novel therapeutic targets for the treatment of GBM. In this study, the expression of circBFAR was significantly increased both in GBM tissues or cell lines and was negatively correlated with overall survival in patients with GBM. Yes Knockdown of circBFAR inhibited proliferation and invasion both in vitro and in vivo. 35202487 MIAT LncRNA Homo sapiens Breast Neoplasms ER, PR, Her2 positive tumor tissues and breast cancer cells Interaction(mir-302, mir-150 and mir-29c) qRT-PCR Unlike P53 positive tumors, MIAT expression was upregulated in ER, PR, Her2 positive tumor tissues. An increase in the expression of mir-302, mir-150, and a decrease in the expression of mir-29c were detected following MIAT silencing. More importantly, knockdown MIAT significantly elevated the expression of p16Ink4A and Cox2, which commitment cellular senescence in breast cancer cells. Yes Knockdown MIAT suppressed breast cancer cell proliferation and caused G1 arrest in cell cycle. Furthermore, downregulation of MIAT promoted apoptosis and significantly decreased migration of breast cancer cells. 29345338 MIAT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[ MIAT/miR-128-3p/PELI3 signaling] Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We demonstrated the aberrant upregulation of MIAT in NSCLC and its association with tumor progression.Our study highlighted the mechanistic contribution of the MIAT/miR-128-3p/PELI3 signaling cascade in NSCLC. Yes MIAT deficiency significantly compromised cell viability, proliferation, invasion, and migration, while increased miR-128-3p and decreased PELI3 expressions. 32556677 circRAD23B CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[miR-593-3p/CCND2 and miR-653-5p/TIAM1 pathways] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay The findings demonstrated that circ-RAD23B, identified to be amplified and overexpressed in NSCLC, was associated with lymph node invasion, lower differentiation grade and shorter overall survival (OS). Mechanistically, circ-RAD23B could sponge miR-593-3p and miR-653-5p and thus elevate CCND2 and TIAM1 expression, respectively. Rescue assays proved that circ-RAD23B promotes cell growth via miR-593-3p/CCND2 axis and facilitates cell invasion by miR-653-5p/TIAM1 pathway. The findings demonstrated that circ-RAD23B, identified to be amplified and overexpressed in NSCLC, was associated with lymph node invasion, lower differentiation grade and shorter overall survival (OS). Yes While, overexpressed circ-RAD23B remarkably downregulated the percentage of apoptotic cells in H1299 cell line (Fig. 2E). 30722989 NEAT1 LncRNA Homo sapiens Prostatic Neoplasms PCa cells Interaction( miR-205-5p via the SFPQ/PTBP2 axis) In Vivo Experiment//RNA Pull-Down//Luciferase Report Assay//Western Blot Collectively, our findings indicated that PCa-derived exosomes-loaded NEAT1 upregulated RUNX2 to facilitate the osteogenesis of hBMSCs by competitively binding to miR-205-5p via the SFPQ/PTBP2 axis, therefore providing a potential therapeutic target to treat osteogenesis of hBMSCs in PCa. Yes Furthermore, in vivo experimentation confirmed that upregulated NEAT1 induced osteogenesis. 34459124 MANCR LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR The present study investigated the potential role of MANCR in gastric cancer (GC) and revealed that MANCR was upregulated in GC tissues compared with non-cancerous tissues. MANCR expression was not affected by clinical stages and a high MANCR expression level was associated with poor survival time. Yes Furthermore, MANCR overexpression promoted, while miR-101 overexpression inhibited GC cell proliferation. 31807188 MILIP LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction[miR-339-5p/MMP15] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay The level of lncRNA MAFG-AS1 is higher in breast carcinoma, and the aggressive phenotypes of breast carcinoma cell are enhanced by MAFG-AS1 transfection.MAFG-AS1 appears to play an oncogene role in breast carcinoma by regulating the miR-339-5p/MMP15. Yes Finally, we demonstrated that the development of breast carcinoma cell is enhanced by MAFG-AS1 in vivo. 31002134 MILIP LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Regulation[MAFG-AS1-miR-339-5p-MMP15 axis ] qRT-PCR In the present study, our data showed that lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAFG-AS1) was over-expressed in NSCLC tissues and cell lines. Altogether, we proved that MAFG-AS1-miR-339-5p-MMP15 axis might be a promising therapeutic target for the treatment of patients with NSCLC. Yes Overexpression of MAFG-AS1 promoted the migration, invasion and enhanced epithelial-mesenchymal transition (EMT) of NSCLC cell. 30599080 MILIP LncRNA Homo sapiens bladder urothelial carcinoma BUC tissues regulation[HuR/PTBP1 axis] IHC//Western Blot//Wound Healing Assay//Co-IP//qRT-PCR//FISH//RIP//MTT//IP//Colony Formation Assay//Transwell Assay Here, we found that the lncRNA MAFG-AS1, which is highly expressed in BUC, is correlated with aggressive characteristics and poor prognosis of BUC. In conclusion, these findings indicate that MAFG-AS1 promotes the progression of BUC via regulation of the HUR/PTBP1 axis. Yes We demonstrate that MAFG-AS1 can promote BUC proliferation, invasion, metastasis, and epithelial-mesenchymal transition in vitro and in vivo. 33377647 MANCR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC cell lines and tissue Expression(highly expressed) Bioinformatics Analysis Furthermore, high expression of MANCR was verified in HNSCC cell lines and tissue by using real-time quantitative PCR (RT-qPCR) analysis. Further enrichment analysis demonstrated that the expression of MANCR was positively correlated with the T gamma delta (tgd) cells, neutrophils, and Th1 cells, and negatively correlated with the infiltration of B cells, CD8 T cells, and T cells in HNSCC. In addition, in vitro experiments showed that knockdown of MANCR in HNSCC cells markedly inhibited cell proliferation, migration, and invasion. We find that MANCR was elevated in HNSCC and promoted the malignant progression of HNSCC. The Kaplan-Meier analysis showed a worse prognosis with higher levels of MANCR for HNSCC. Yes Further enrichment analysis demonstrated that the expression of MANCR was positively correlated with the T gamma delta (tgd) cells, neutrophils, and Th1 cells, and negatively correlated with the infiltration of B cells, CD8 T cells, and T cells in HNSCC. In addition, in vitro experiments showed that knockdown of MANCR in HNSCC cells markedly inhibited cell proliferation, migration, and invasion. We find that MANCR was elevated in HNSCC and promoted the malignant progression of HNSCC. 35873456 circMYLK CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells interaction[Sponging miR-195-5p ] qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The results showed that circMYLK was significantly up-regulated in NSCLC tissues and cell lines, and its high expression was closely associated with deleterious clinicopathological characteristics and poor prognosis of NSCLC patients.Further rescue experiments revealed that the oncogenic effects of circMYLK on NSCLC cells could be largely abrogated by co-transfection with miR-195-5p mimic. The results showed that circMYLK was significantly up-regulated in NSCLC tissues and cell lines, and its high expression was closely associated with deleterious clinicopathological characteristics and poor prognosis of NSCLC patients. Yes Knockdown of circMYLK remarkably inhibited the malignant phenotypes of NSCLC cells, including proliferation, migration, invasion, glucose consumption and lactate production. 32753964 MT1JP LncRNA Homo sapiens Carcinoma, Hepatocellular Serum regulation[Regulating miR-24-3p] qRT-PCR//Luciferase Report Assay The expression of MT1JP was downregulated (P < 0.05), whereas that of miR-24-3p was upregulated in liver cancer.MT1JP, even when expressed at low levels, participates in the proliferation, apoptosis, and migration of liver cancer cells by regulating miR-24-3p. Serum MT1JP levels were correlated with tumor size, alpha-fetoprotein (AFP), TNM stage, differentiation, and lymph node metastasis. Yes Both MT1JP overexpression and miR-24-3p inhibition inhibited cellular proliferation and migration and increased apoptosis rates. 32606962 NEAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck One hundred two paraffin samples of LSCC patients Expression [highly expressed] qRT-PCR//MTT//Colony Formation Assay In this study, ISH revealed that NEAT1 was strongly expressed in the nucleus. The increased expression of NEAT1 was correlated with T grade, neck nodal metastasis, clinical stage, drinking history, or smoking history of LSCC. The Kaplan-Meier analysis indicated that patients with higher NEAT1 expression had a worse overall survival in LSCC patients. Yes In addition, NEAT1 knockdown significantly inhibited the growth of LSCC cells. 33831864 circPOSTN CircRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-433-3p/SPARC axis) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay circ_POSTN and SPARC were upregulated while miR-433-3p was downregulated in glioma tissues and cells. Both circ_POSTN and SPARC knockdown inhibited clonogenicity, migration, and promoted apoptosis of glioma cells. Circ_POSTN sponged miR-433-3p to regulate SPARC expression. Gain of SPARC largely attenuated circ_POSTN knockdown or miR-433-3p overexpression-mediated effects on glioma cell clonogenicity, migration, and apoptosis. Furthermore, silencing of circ_POSTN decreased xenograft tumor growth in vivo. Inhibition of circ_POSTN repressed glioma development, at least in part, via regulating the miR-433-3p/SPARC axis, providing evidence for circ_POSTN as a potential therapeutic target for glioma. Yes Both circ_POSTN and SPARC knockdown inhibited clonogenicity, migration, and promoted apoptosis of glioma cells. Circ_POSTN sponged miR-433-3p to regulate SPARC expression. Gain of SPARC largely attenuated circ_POSTN knockdown or miR-433-3p overexpression-mediated effects on glioma cell clonogenicity, migration, and apoptosis. 36454505 MANCR LncRNA Homo sapiens Stomach Neoplasms cell lines(BGC-823, SGC-7901, and MGC-803) Interaction[miR-16] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay n addition, CR749391 was observed to be Expression[down-expression]regulated in GC compared with that of normal gastric cell lines.In addition, CR749391 was observed to be Expression[down-expression]regulated in GC compared with that of normal gastric tissues, which was associated with KLF6 but inversely associated with miR-181a levels. Overall, the CR749391/miR-181a regulatory interaction and association between CR749391 and KLF6 may enhance the current understanding of GC pathogenesis, although CR749391 association with GC prognosis needs further study. Yes A functional study also revealed that CR749391 depletion in normal gastric epithelial cells promoted cell viability, migration and invasion, and conferred resistance to apoptosis, whereas ectopic CR749391 overexpression had the opposite effect in GC cells and inhibited in vivo tumor growth. 31853323 MAP4K2 CircRNA Homo sapiens diabetic retinopathy endothelial cell Interaction(miR-377/VEGFA) RNA Pull-Down//Transfection//Tube Formation Assay//Migration Assay//Proliferation Assay//qRT-PCR//RIP//MTT//migration assay//PCR//Cell Proliferation Assay//IP//ELISA//IF Clinically, cMAP4K2 expression was significantly up-regulated in the clinical sample of DR patients. Mechanistically, cMAP4K2 acted as miR-377 sponge to affect the biological activity of miR-377, which led to increased expression of vascular endothelial growth factor A (VEGFA). Yes Silencing of cMAP4K2 could reduce endothelial cell viability, proliferation, migration, and tube formation in vitro and alleviate retinal vascular dysfunction in vivo as shown by decreased vascular leakage and inflammation. By contrast, cMAP4K2 overexpression had an opposite effect on retinal vascular dysfunction. 35963645 NEAT1 LncRNA Homo sapiens Prostatic Neoplasms PCa and matched adjacent healthy control (HC) tissues,cell lines( LNCaP, PC-3, DU-145 ,RWPE-1) Interaction[miR-98-5p;HMAG2] qRT-PCR//Luciferase Report Assay//RIP//Western Blot it is clearly showed that the expression level of NEAT1 is significantly Expression[Expression[up-expression]-expression]-regulated in PCa tissues, compared with BPH (P<0.0001) and HC tissues (P<0.0001, with average 6.42-fold increase compared with matched healthy tissues, Figure 1B).In addition, luciference assay and RNA immunoprecipitation (RIP) assay confirmed that NEAT1 can function as a competing endogenous RNA (ceRNA) by sponging miR-98-5p to active HMGA2. Moreover, silencing of HMGA2 can decrease the proliferation ability of PCa cells. Taken together, NEAT1/miR-98-5p/HMGA2 pathway is involved in the development and progression of PCa. Yes Consistently, the overexpression of NEAT1 in PCa is also validated in cell lines, as shown that NEAT1 is Expression[Expression[up-expression]-expression]-regulated in DU145, PC3 and LNCaP PCa cell lines compared with normal prostate epithelial cell line RWPE- 1 (​(FigureFigure 1C). We subsequently treated PC3 cells by using HMGA2 siRNA or NC. As shown in Figure 3A, the cell viability was remarkably sExpression[Expression[up-expression]-expression]pressed by HMGA2 knockExpression[down-expression]. In addition, HMGA2 inhibition led to the reduced colony formation (Figure 3B) and invasion ability (Figure 3C). Collectively, these findings confirmed that HMGA2 functions as oncogene in PCa cells. 31481527 MT1JP LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissue regulation[regulating AKT] CCK8//qRT-PCR//Colony Formation Assay//Flow Cytometry In this experiment, qRT-PCR results showed that the expression level of lncRNA MT1JP in tumor tissues of HCC patients was remarkably lower than that in adjacent tissues, and the difference was statistically significant. LncRNA MT1JP expression is remarkably decreased in HCC tumor tissue samples, which is associated with pathological stage and poor prognosis of HCC patients. In addition, MT1JP may inhibit the malignant progression of HCC by downregulating AKT. Meanwhile, compared with patients with high expression of MT1JP, patients with low expression of MT1JP had a higher pathological staging and a lower overall survival rate. Yes In addition, overexpression of MT1JP remarkably attenuated the proliferation ability of HCC cells but enhanced cell apoptosis rate at the same time. 32633354 circKIF4A CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction( miR-335-5p/ALDOA ) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In our study, circKIF4A was identified as a remarkably upregulated circRNA expressed in glioma tissues and cell lines. The glycolysis regulating enzyme ALDOA was regulated by circKIF4A through the mechanism of interactivity with miR-335-5p in glioma cells. In a word, our data showed that the upregulation of circKIF4A facilitates glioma progression by means of binding miR-335-5p and upregulating ALDOA expression. Yes We discovered that knockdown of circKIF4A remarkably decreased the proliferation and invasion ability of glioma cells. Moreover, subcutaneous tumorigenesis model and intracranial injection of orthotopic glioma model were established to investigate the functions of circKIF4A in vivo. 36030248 circCCNB1 CircRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-516b-5p and HuR) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//IHC CircCCNB1 was overexpressed in glioma tissues and cells. EIF4A3 positively regulated circCCNB1 expression. CircCCNB1 knockdown reduced CCND1 expression in glioma cells and CCND1 overexpression bated the effect of circCCNB1 knockdown on glioma cell growth. CircCCNB1 interacted with HuR to elevate CCND1 expression. miR-516b-5p could interact with circCCNB1 and CCND1. CircCCNB1 regulated glioma cell progression and CCND1 expression by miR-516b-5p and HuR. CircCCNB1 aggravated glioma cell growth by elevating CCND1 through targeting miR-516b-5p and HuR. Yes CircCCNB1 knockdown repressed glioma cell proliferation and cell cycle process in vitro and blocked tumor growth in vivo. 35038081 hsa_circ_0016760 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-577/ZBTB7A Axis] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0016760 and ZBTB7A were upregulated and miR-577 was downregulated in NSCLC tissues and cells.Circ_0016760 silencing impeded NSCLC advancement through regulation of the miR-577/ZBTB7A axis. Yes Circ_0016760 exhaustion curbed the colony formation, migration, invasion, and ECAR of NSCLC cells in vitro and impeded tumor growth in vivo. 32753969 circTOP2A CircRNA Homo sapiens Glioma glioma tissues and cell lines Regulation(RPN2/Wnt/β-catenin pathway ) In Vivo Experiment//Western Blot//Transfection//CCK8//FISH//qRT-PCR//Luciferase Report Assay//Microarray//IHC//IF circTOP2A was significantly overexpressed in glioma and conferred a poor prognosis. circTOP2A could regulate RPN2 expression by sponging miR-422a, verified by western blot, dual-luciferase reporter gene assay, and RNA pull-down assay.Additionally, TOP/FOP and immunofluorescence analysis were used to confirm that sh-circTOP2A could suppress the Wnt/β-catenin pathway partly through RPN2. circTOP2A was significantly overexpressed in glioma and conferred a poor prognosis. Yes Functional assays including CCK8, transwell and FITC-annexin V were performed to explore the RPN2-mediated role of the circTOP2A effect on the glioma malignant phenotype. Finally, a tumor xenograft model was applied to validate the biological function of circTOP2A in vivo. 36227125 MAP3K1-2 LncRNA Homo sapiens Stomach Neoplasms GC cells Expression[highly expressed] Flow Cytometry//qRT-PCR//Transwell Assay//Western Blot The expression level of lncRNA MAP3K1-2 was upregulated in GC cells and markedly higher in poorly differentiated cell lines. Yes Silencing treatment of lncRNA MAP3K1-2 significantly inhibited cell proliferation and invasion in GC. 30122954 MAP3K20-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue,cell lines Interaction[downregulation of p21 ] qRT-PCR//MTT//EdU Staining//Western Blot The results of reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) revealed a significant upregulation of MLK7‑AS1 in both CRC tissue samples and cell lines. Furthermore, RT‑qPCR and western blot assays revealed that p21 may be a potential downstream target of MLK7‑AS1. To the best of the authors' knowledge, this is the first study to report that MLK7‑AS1 has potential as a biomarker and may promote proliferation in CRC partially through downregulating p21 expression. Yes Importantly, MLK7‑AS1 knockdown suppressed CRC cell proliferation and promoted G1/G0 phase arrest and apoptosis in vitro, whereas MLK7‑AS1 overexpression exhibited opposite effects. Consistently, decreased MLK7‑AS1 expression inhibited tumor growth in vivo. 30535460 MT1JP LncRNA Homo sapiens Breast Neoplasms BC tissues regulation[miRNA-214/RUNX3 Axis] Wound Healing Assay//Tunel//Flow Cytometry//qRT-PCR//Transwell Assay Compared with adjacent tissues, MT1JP and miRNA-214 gene expressions were significantly different (P<0.001, respectively).The overexpression of MT1JP suppresses the biological activities of breast cancer cells by regulation miRNA-214/RUNX3 axis in vitro and vivo study. Yes By in vitro and in vivo studies, the biological activities of the cells were significantly decreased in MDA-MB-231 and MCF-7 cell lines with MT1JP overexpression. 32581560 MIAT LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues,cell lines regulation[INCENP/miR-1301-3p axis] qRT-PCR In this study, we found that MIAT was significantly increased in ESCC tissues, as well as cell lines.Our findings indicated that MIAT promoted ESCC progression via targeting INCENP/miR-1301-3p axis and interacting with SOX2, suggesting novel potential therapeutic targets for ESCC. Yes Downregulation of MIAT suppressed ESCC cell proliferation, cell cycle, migration, and invasion. 31943174 NEAT1 LncRNA Homo sapiens Retinoblastoma RB tissues and cell lines Regulation[miR-204/CXCR4 axis] qRT-PCR We found NEAT1 and CXCR4 expression levels were elevated, whereas miR-204 expression was decreased in RB tissues and cells.In conclusion, NEAT1 promotes the development of RB via miR-204/CXCR4 axis, which provides a new target for the treatment of RB disease. Yes Knockdown of NEAT1 suppressed the tumor volume, tumor weight, and CXCR4 expression, whereas increased miR-204 expression in mice. Downregulation of NEAT1 significantly decreased the proliferation and migration but promoted the apoptosis of RB cells. 30479013 hsa_circ_0074027 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[miR-185-3p/BRD4/MADD pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Circ_0074027 was elevated in NSCLC specimens and cell lines.For mechanism investigation, circ_0074027 directly sponges miR-185-3p to enhance bromodomain-containing protein 4 (BRD4) and MAPK-activating death domain-containing protein (MADD) expression levels at the posttranscriptional level. Furthermore, we found the oncogenic function of circ_0074027 is attributed to its modulation of BRD4 and MADD. Collectively, upregulated circ_0074027 in NSCLC accelerates cell progression via miR-185-3p/BRD4/MADD pathway as a competing endogenous RNA. Overexpressed circ_0074027 was related to more advanced TNM stages, poorer differentiation grade, and worse overall survival. Yes Upregulated circ_0074027 increased the proliferation of H1299 cells by inhibiting cell apoptosis. Cell migration and invasion were enhanced after circ_0074027 overexpression. Silenced circ_0074027 caused the opposite effects in the A549 cell line. 31680319 NEAT1 LncRNA Homo sapiens Laryngeal Neoplasms laryngocarcinoma tissues and cells Interaction(miR-524-5p /HDAC1 axis ) In Vivo Experiment//Western Blot//ISH//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Transwell Assay Our study validated that NEAT1 expression was markedly upregulated in laryngocarcinoma tissues and cells.Taken together, knockdown of NEAT1 suppressed laryngocarcinoma cell growth and metastasis by miR-524-5p/HDAC1/PTEN/AKT signal pathway, which provided a potential therapeutic target for laryngocarcinoma. Yes Downregulation of NEAT1 dramatically suppressed cell proliferation and invasion through inhibiting miR-524-5p expression. Additionally, NEAT1 overexpression promoted cell growth and metastasis, while overexpression of miR-524-5p could reverse the effect. 34837887 MAPK8IP1P2 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues regulation[ miR-146b-3p] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay Here, we reported that MAPK8IP1P2 was downregulated in thyroid cancer tissues with lymphatic metastasis. Mechanistically, MAPK8IP1P2 activated Hippo signaling by sponging miR-146b-3p to disrupt the inhibitory effect of miR-146b-3p on NF2, RASSF1, and RASSF5 expression, which further inhibited anoikis resistance and lymphatic metastasis in thyroid cancer. Yes Upregulating MAPK8IP1P2 inhibited, while silencing MAPK8IP1P2 enhanced anoikis resistance in vitro and lymphatic metastasis of thyroid cancer cells in vivo. 33489905 MAPKAPK5_AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cancerous tissues Interaction( c-Myc) In Vivo Experiment//Western Blot//Transfection//MeRIP//Co-IP//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//IHC//Bioinformatics Analysis//ChIP MAAS was upregulated in HBV-related HCC cancerous tissues and its high expression was closely related to the poor survival probability of patients. Mechanistically, MAAS promoted the MYC proto-oncogene (c-Myc)-induced transcriptional activation of cyclin-dependent kinase 4 (CDK4), CDK6, and S-phase kinase associated protein 2 via stabilizing c-Myc protein, thereby facilitating G1/S transition. The latter contributed to the paradoxical proliferation of HBV+HCC cells. Yes Functional assays revealed that MAAS overexpression facilitated the proliferation of HBV+HCC cells in vitro and in vivo. 35264707 MIR503HG LncRNA Homo sapiens Pre-Eclampsia placental tissues Regulation[ NF-κB signaling pathway] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Transwell Assay The highly expressed MIR503HG was detected in PE placental tissues compared to normal placental tissues.Western blot assay results showed that MIR503HG overexpression suppressed the matrix metalloproteinase-2/-9 and the snail protein expression and increased the E-cadherin expression in trophoblast cells. In addition, MIR503HG overexpression suppressed the NF-κB signaling pathway by inhibiting the phosphorylation of IκBα and the nuclear translocation of NF-κB signaling subunit p65. On the other hand, MIR503HG knockdown played an opposite role in these protein expression levels. Yes MIR503HG overexpression suppressed cell proliferation, invasion, and migration of HTR-8/SVneo and JEG3 cells, while knockdown of MIR503HG increased trophoblast cell proliferation, invasion, and migration. 31467616 hsa_circ_0005273 CircRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues regulation[targeting KLF12] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay It was found that circ_0005273 was upregulated in pancreatic cancer tissues than that in normal tissues.Circ_0005273 drives proliferative and migratory abilities of pancreatic cancer cells via activating the KLF12, and it is able to predict lymphatic metastasis, distant metastasis and prognosis in pancreatic cancer patients. Besides, pancreatic cancer patients expressing a high level of circ_0005273 had higher incidence rates of lymphatic metastasis and distant metastasis, as well as poor prognosis. Yes Knockdown of circ_0005273 weakened the proliferative and migratory abilities of AsPC-1 and CFPAC-1 cells. 33275224 MAPKAPK5-AS1 LncRNA Homo sapiens Thyroid Neoplasms cell lines regulation[targeting miR-519e-5p/YWHAH] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining//Transwell Assay Results of RT-qPCR analysis demonstrated that MAPKAPK5-AS1 was more highly expressed in thyroid cancer cells compared to normal cells. Ultimately, our study revealed that MAPKAPK5-AS1 promotes proliferation and migration of thyroid cancer cells by targeting the miR-519e-5p/YWHAH axis, which provides novel insight into the development and progression of thyroid cancer. Yes Functional assays demonstrated that interfering with the expression of MAPKAPK5-AS1 notably repressed proliferation and invasion and accelerated apoptosis of BCPAP and TPC-1 cells. 33272009 NEAT1 LncRNA Homo sapiens Rhinitis, Allergic AR and IL-13-treated HNECs Interaction(miR-511/NR4A2 axis) Western Blot//Transfection//Tunel//qRT-PCR//Luciferase Report Assay//ELISA In this study, we found that the NEAT1 level was highly expressed in AR and IL-13-treated HNECs. In conclusion, our data revealed that exosomal NEAT1 contributed to the pathogenesis of AR through the miR-511/NR4A2 axis. These findings might offer novel strategies for the prevention and treatment of AR. Yes NEAT1 interference significantly suppressed levels of GM-CSF, eotaxin-1, and MUC5AC and apoptosis rate, but promoted the viability of IL-13-treated human nasal epithelial cells (HNECs). Moreover, exosomes containing NEAT1 induced inflammatory cytokine production and apoptosis, while NEAT1 depletion abrogated these effects. 34672863 hsa_circ_001587 CircRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines interaction[binding to microRNA-223] qRT-PCR//Luciferase Report Assay hsa_circRNA_001587 was poorly expressed, but miR-223 was highly expressed in PC tissues and cell lines. Therefore, hsa_circRNA_001587 inhibits PC cell migration, invasion, angiogenesis and tumorigenesis by impairing miR-223-mediated SLC4A4 inhibition. Yes Upregulation of hsa_circRNA_001587 downregulated the expression of matrix metalloproteinase-2 and-9, minichromosome maintenance 2, and vascular endothelial growth factor, and decreased the proliferation, migration, invasion, angiogenic and tumorigenic abilities of PC cells. 32878470 hsa_circ_0000285 CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-599/GNG12 axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Bioinformatics Analysis We found glioma tissues and cell lines were overexpressing hsa_circ_0000285. Using bioinformatic analysis and verification experiments for studying its mechanisms, we confirmed that hsa_circ_0000285 sponged miR-599, which negatively regulated GNG12 by binding to its mRNA. Yes While hsa_circ_0000285 promoted cell proliferation and migration, it inhibited apoptosis in vitro. It also increased tumor volume and weight in vivo. 35060646 NEAT1 LncRNA Homo sapiens Retinoblastoma retinoblastoma tissues Regulation[modulating miR-124] qRT-PCR Our data show enhanced NEAT1 expression in RB-affected tissues compared with the corresponding control. Thus, NEAT1 promotes RB progression by sponging miR-124, providing a therapeutic target for RB. Yes Functional experiments reveal that a NEAT1 knockdown in RB cells significantly inhibits proliferation, cycle progression, and facilitates apoptosis and caspase-3 and -9 activities. 31038819 NEAT1 LncRNA Homo sapiens Diabetic Nephropathies HK-2 cells Interaction(miR-150-5p/DRP1 ) Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay Our results showed that in response to high glucose the NEAT1 and DRP1 levels were upregulated, whereas the miR-150-5p level was downregulated in HK-2 cells. Mechanistically, NEAT1 sponged miR-150-5p to increase the DRP1 level. Moreover, silencing of NEAT1 or DRP1 could counteract miR-150-5p inhibition-induced deleterious effects. Yes Knockdown of NEAT1 or DRP1 in high glucose-challenged HK-2 cells inhibited excessive reactive oxygen species production and lactate dehydrogenase release, increased cell viability, mitochondrial membrane potential and superoxide dismutase activity and enhanced mitophagy. Inhibition of miR-150-5p resulted in the opposite results. 33914383 MAPKAPK5-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(miR-429/ZEB1 axis) qRT-PCR MAPKAPK5-AS1 and ZEB1 expressions were up-regulated in HCC tissues, and miR-429 expression is down-regulated in HCC tissues. MiR-429 was validated to be the target of MAPKAPK5-AS1, and miR-429 inhibitors could partially offset the effects of knocking down MAPKAPK5-AS1 on HCC cells. MAPKAPK5-AS1 could positively regulate ZEB1 expression through repressing miR-429. Moreover, fewer lung metastatic nodules were observed in the lung tissues of nude mice when the MAPKAPK5-AS1 was knocked down in HCC cells. Yes MAPKAPK5-AS1 knockdown could significantly impede HCC cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT), as well as promote cell apoptosis.MAPKAPK5-AS1 overexpression could enhance L02 cell proliferation, migration, invasion and EMT, and inhibit cell apoptosis. 35468721 MAPKAPK5-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction( miR-376b-5p/ECT2) In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//cell invasion assay MK5-AS1 expression was significantly upregulated in HCC tissues and cell lines. Bioinformatics analysis based on Lncbase, miRDB and TargetScan databases showed MK5-AS1 competitively bound to miR-376b-5p that prevented epithelial cell transforming sequence 2 (ECT2) from miRNA-mediated degradation, thus facilitated HCC metastasis. Furthermore, high MK5-AS1 expression was positively associated with tumor progression and poor prognosis. Yes In vitro and in vivo experiments confirmed that overexpressed MK5-AS1 promoted migration and invasion of HCC cells. 36567178 MAPKAPK5-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction(PLAGL2/HIF-1α signaling loop ) qRT-PCR MAPKAPK5-AS1 expression was significantly elevated in HCC, and its overexpression associated with malignant clinical features and reduced survival. Our results reveal a MAPKAPK5-AS1/PLAGL2/HIF-1α signaling loop in HCC progression and suggest that MAPKAPK5-AS1 could be a potential novel therapeutic target of HCC. MAPKAPK5-AS1 expression was significantly elevated in HCC, and its overexpression associated with malignant clinical features and reduced survival. Yes Functionally, MAPKAPK5-AS1 knockdown repressed the proliferation, mobility, and EMT of HCC cells and induced apoptosis. Ectopic expression of MAPKAPK5-AS1 contributed to HCC cell proliferation and invasion in vitro. Furthermore, MAPKAPK5-AS1 silencing suppressed, while MAPKAPK5-AS1 overexpression enhanced HCC growth and lung metastasis in vivo. 33596983 MTA2TR LncRNA Homo sapiens Pancreatic Neoplasms PC tissues Interaction[HIF-1α] RNA Pull-Down//Northern Blot//Western Blot//FISH//RIP//Luciferase Report Assay//Microarray//ChIP We found that metastasis associated protein 2 (MTA2) transcriptional regulator lncRNA (MTA2TR) was overexpressed in PC patient tissues relative to paired noncancerous tissues.We further demonstrated that MTA2TR transcriptionally upregulates MTA2 expression by recruiting activating transcription factor 3 (ATF3) to the promoter area of MTA2. Consequentially, MTA2 can stabilize the HIF-1α protein via deacetylation, which further activates HIF-1α transcriptional activity. Interestingly, our results revealed that MTA2TR is transcriptionally regulated by HIF-1α under hypoxic conditions. Our clinical samples further indicated that the overexpression of MTA2TR was correlated with MTA2 upregulation, as well as with reduced overall survival (OS) in PC patients. Yes Furthermore, we found that depletion of MTA2TR significantly inhibited PC cell proliferation and invasion both in vitro and in vivo. 31410216 NEAT1 LncRNA Homo sapiens Inflammatory Bowel Diseases colon biopsy tissues Interaction(TNFRSF1B) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//ELISA//IF In patients' specimens and DSS colitis mouse models, NEAT1 and TNFRSF1B expression were up-regulated compared with the control group. Moreover, NEAT1 co-precipitates TNFRSF1B mRNA in RNA-pulldown assay, and the presence of NEAT1 stabilizes the mRNA of TNFRSF1B. Yes In the presence of TNF-α stimulation, NEAT1 knockdown reduces the expression of TNFRSF1B and the translocation of NF-κB p65, thereby relieves cell inflammation. These effects can be reversed by the overexpression of TNFRSF1B. 34268386 circSFMBT1 CircRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells regulation[miR-330-5p/PAK1 axis] Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay This study demonstrated that circSFMBT1 and PAK1 were up-regulated in PC tissues and cells, while miR-330-5p was down-regulated. Taken together, circSFMBT1 promotes proliferation and metastasis of PC via regulating miR-330-5p/PAK1 pathway as a miR-330-5p sponge. Yes In addition, circSFMBT1 promoted proliferation, migration, and invasion of PC cells through up-regulating proliferation-related proteins and down-regulating apoptosis-related proteins via miR-330-5p. 32855541 MAPKAPK5-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[silencing p21] qRT-PCR Expression of MAPKAPK5-AS1 was significantly upregulated in 50 CRC tissues.We also found that p21 is a target of MAPKAPK5-AS1. In addition, we are the first to report that MAPKAPK5-AS1 plays a carcinogenic role in CRC. MAPKAPK5-AS1 is a novel prognostic biomarker and a potential therapeutic candidate for CRC cancer. Expression of MAPKAPK5-AS1 was significantly upregulated in 50 CRC tissues, and increased expression of MAPKAPK5-AS1 was found to be associated with greater tumor size and advanced pathological stage in CRC patients. Yes Knockdown of MAPKAPK5-AS1 significantly inhibited proliferation and caused apoptosis in CRC cells. 30343528 NEAT1 LncRNA Homo sapiens Liver Neoplasms HepG2 cells Interaction(NEAT1/WNT/β-catenin ) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//IHC//EdU Staining//IF Therefore, our findings provide evidence that ECM-derived mechanical signals regulate cell proliferation and drive EMT through a NEAT1/WNT/β-catenin mechanotransduction pathway in the tumor microenvironment of liver cancer. Yes Furthermore, nuclear paraspeckle assembly transcript 1 (NEAT1) was identified as a matrix stiffness-responsive long non-coding RNA (lncRNA) regulating proliferation and EMT in response to increasing matrix stiffness during the progression of HepG2 cells towards liver cancer phenotypes. Higher matrix stiffness contributed to enhancing NEAT1 expression, which activated the WNT/β-catenin pathway. 34769497 NEAT1 LncRNA Homo sapiens tongue squamous cell carcinoma cell line regulation[miR-339-5p/ITGA3 axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Compared with normal human oral mucosal cell line HOK, the expression of NEAT1 and ITGA3 was up-regulated, while the expression of miR-339-5p was down-regulated in human tongue squamous cell carcinoma cell lines. LncRNA NEAT1 promotes proliferation, migration and invasion of tongue squamous cell carcinoma cells by down-regulating miR-339-5p/ITGA3 axis. Yes Inhibition of NEAT1 or over-expression of miR-339-5p significantly inhibited proliferation, migration and invasion of CAL27 cells, and significantly inhibited expression of Cyclin D1 and MMP-9 proteins. 33043343 MIAT LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Regulation[mir-128-3p/VEGFC axis] qRT-PCR In the present study, we found that lncRNA MIAT was significantly up-regulated in both OS tissues and cell lines Moreover, the expression of MIAT was negatively associated with miR-128-3p but positively correlated with vascular endothelial growth factor C (VEGFC) in OS. Further mechanistic study revealed that lncRNA MIAT promoted OS progression by up-regulating VEGFC via sponging miR-128-3p in vitro. Taken together, our results suggest that MIAT/miR-128-3p/VEGFC axis contributes to OS progression and may be used as a novel therapeutic target for OS. In the present study, we found that lncRNA MIAT was significantly up-regulated in both OS tissues and cell lines, and high expression of MIAT was positively associated with tumor size and lymph node metastasis of OS patients. Yes In addition, knockdown of MIAT inhibited proliferation, migration, invasion and promoted apoptosis of OS cells in vitro. 30629798 NEAT1 LncRNA Homo sapiens Retinoblastoma RB tissues regulation[miR-3619-5p/LASP1 Axis] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay NEAT1 expression was dramatically up-regulated, and miR-3619-5p expression was obviously downregulated in RB tissues and cells compared with control groups. Yes Functionally, NEAT1 silencing inhibited RB cell migration, invasion, and proliferation, whereas induced cell apoptosis and cell cycle arrest in RB; this phenomenon was partially abolished by miR-3619-5p inhibitor. 33281873 NEAT1 LncRNA Homo sapiens Retinoblastoma retinoblastoma tissues, cells and serum Interaction(miR-148b-3p/ROCK1 axis) qRT-PCR//Luciferase Report Assay//Western Blot  It was found that LncRNA NEAT1 was up-regulated in retinoblastoma tissues, cells and serum, and the prognosis of patients with high expression of LNC RNA NEAT 1 was poor. In addition, LncRNA NEAT1 inhibited proliferation and invasion, and promoted apoptosis through miR-148b-3p/ROCK1 axis. the prognosis of patients with high expression of LNC RNA NEAT 1 was poor Yes Functional analysis showed that knocking down LncRNA NEAT1 could weaken proliferation and invasion, and accelerate apoptosis. Tumor allogeneic experiment showed that sh-NEAT1 injection can inhibit tumor growth. 34285579 NEAT1 LncRNA Homo sapiens Retinoblastoma tissues and cells Interaction(miR-24-3p/LRG1 axis) qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay In the present study, NEAT1 and LRG1 were upregulated, and miR-24-3p was downregulated in RB tissues and cells compared with the corresponding healthy tissues and cells. Moreover, miR-24-3p was identified as a target of NEAT and LRG1 was demonstrated to be a direct target gene of miR-24-3p. It was also demonstrated that NEAT1 knockdown inhibited the epithelial-to-mesenchymal transition (EMT) pathway by inhibiting the expression of LRG via targeting miR-24-3p. Yes Knockdown of NEAT1 or LRG1 significantly suppressed RB cell migration and invasion ability, while the effects were reversed by an miR-24-3p inhibitor. In addition, the downregulation of LRG1 caused by miR-24-3p was restored following the overexpression of NEAT1 in RB cells. 33732340 MIAT LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[miR-488-3p/IGF1R Pathway] RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay "LncRNA MIAT was upregulated in CRC sample and that was positively correlated with IGF1R expression.The present study confirmed that the ""MIAT/miR-488-3p/IGF1R"" pathway was involved in the development of CRC, which may be the target for developing therapeutic approaches for CRC." Yes Loss-of-functional assay suggested that knockdown of MIAT impeded cell activity, migration, invasion, and glycolysis of CRC cells in vivo, along with xenograft growth in vivo. 33085926 NEAT1 LncRNA Homo sapiens Melanoma cell lines Interaction[regulating miR-495-3p and E2F3] qRT-PCR In our present research, we displayed NEAT1 was overexpressed in melanoma cells.Mechanistically, it was revealed that NEAT1 could directly bind with miR-495-3p, which led to a negative effect on miR-495-3p levels. In addition, miR-495-3p was significantly decreased in melanoma cells. Furthermore, E2F3 was postulated as the target of miR-495-3p and overexpression of this miR could suppress the levels of E2F3. Meanwhile, it was exhibited that melanoma cell proliferation, migration, and invasion induced by E2F3 silence was abrogated by miR-495-3p. Moreover, an in vivo xenograft nude mice model was established using A375 cells and it was indicated that NEAT1 promoted melanoma progression in vivo via regulating the miR-495-3p/E2F3 axis. Yes A series of functional assays showed that overexpression of NEAT1 promoted the proliferation, migration, and invasion of melanoma cells. By contrast, NEAT1 knockdown obviously restrained melanoma cell progression. 31173352 NEAT1 LncRNA Homo sapiens Melanoma melanoma tissues,cells regulation[NEAT1/miR-200b-3p/SMAD2 axis] qRT-PCR//Luciferase Report Assay RT-qPCR and RNAscope assays revealed that expression of NEAT1 in melanoma tissues (n=18) was significantly higher than that in benign naevus (n=18) (Figure 4B–4D). Furthermore, the level of NEAT1 in various melanoma cell lines (A375, A875 and M14) was found to be higher than that of non-cancer cells as well (Figure 4E). These results showed that NEAT1 was up-regulated in melanoma cells.Taken together, the NEAT1/miR-200b-3p/SMAD2 signaling pathway promotes melanoma via activation of EMT, cell invasion and is related with immune responses, which provides new insights into the molecular mechanisms and therapeutic targets for melanoma. Yes In vitro and in vivo, we demonstrated that both NEAT1 and SMAD2 could promote the proliferation and invasion of melanoma cells, and these effects were reversed by up-regulating miR-200b-3p. 33202380 NEAT1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues, cell lines Regulation[miR-144-3p/EZH2 axis] Western Blot//qPCR//MTT//Luciferase Report Assay//Transwell Assay Results NEAT1 was highly expressed in EC tissues and cells.Additionally, NEAT1 acted as a ceRNA of miR-144-3p, leading to EZH2 upregulation. Overexpression of miR-144-3p suppressed the proliferation and invasion of EC cells. Yes Knockdown of NEAT1 inhibited the proliferation, migration and invasion of EC cells. Additionally, NEAT1 acted as a ceRNA of miR-144-3p, leading to EZH2 upregulation. Overexpression of miR-144-3p suppressed the proliferation and invasion of EC cells. 31747378 NEAT1 LncRNA Homo sapiens Endometrial Neoplasms EC tumors and cells regulation[miR-202-3p,TIMD4 ] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay NEAT1 was upregulated, whereas miR-202-3p was downregulated in EC tumors and cells. Upregulation of NEAT1 accelerated EC cell progression through sponging miR-202-3p to facilitate TIMD4 expression, providing potential novel treatment method for EC. Yes Depletion of NEAT1 restrained EC cell proliferation, migration, invasion, and improved apoptosis. 32882142 hsa_circ_0078767 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-665/GPX3 ) In Vivo Experiment//qRT-PCR//Colony Formation Assay//Western Blot The expression of circ_0078767 and GPX3 was decreased in NSCLC tissues, while the expression of miR-665 was increased.Circ_0078767 can sponge miR-665, and GPX3 is the target of miR-665. Mechanically, circ_0078767 regulates the GPX3 expression in NSCLC cells by spongy miR-665. In addition, in vivo studies have shown that downregulation of circ_0078767 promotes tumor growth. Circ_0078767 silencing promotes proliferation, migration, invasion, and glycolysis of NSCLC cells by regulating the miR-665/GPX3 axis, suggesting that circ_0078767/miR-665/GPX3 axis may be a potential regulatory mechanism for the treatment of NSCLC. Yes In vitro complement experiments showed that knockdown of circ_0078767 significantly promoted malignant behavior of NSCLC, while cotransfection of miR-665 inhibitor partially reduced this change. In addition, the GPX3 overexpression decreased the promoting effects of miR-665 upregulation on proliferation, migration, and invasion of NSCLC cells. 35340708 MIAT LncRNA Homo sapiens Osteoarthritis OA cartilage tissues Interaction(miR-181a-5p/OPN axis) Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//BrdU A total of six long non-coding RNAs (lncRNAs) were predicted to target miR-181a-5p, and MIAT was the most up-regulated in OA cartilage tissues among the six lncRNAs. Through direct targeting, MIAT inhibited miR-181a-5p expression.The lncRNA MIAT/miR-181a-5p/OPN axis could modulate OA chondrocyte proliferation and apoptosis. Yes MIAT silencing inhibited cell viability, suppressed DNA synthesis, and promoted cell apoptosis. Moreover, miR-181a-5p inhibition partially reversed the effects of MIAT silencing on OA chondrocytes. 35286539 MIAT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[sponging miR-22-3p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Mechanistic study revealed that SAL-miat acted as a competitive endogenous RNA (ceRNA) that upregulated the expression of sirt1 by sponging miR-22-3p. Moreover, miat downregulation activated the tumor suppressor pathway (p53/p21 and p16/pRb) and stimulated senescent cancer cells to secrete senescence-associated secretory phenotype (SASP), which contributed to inhibition of tumor cell proliferation, and resulted in the suppression of HCC tumorigenesis. Yes Knockdown of miat significantly promoted cellular senescence and inhibited HCC progression. 31503007 MIAT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction( miR-411-5p/STAT3/PD-L1 axis) qRT-PCR We found that MIAT and PD-L1 were significantly upregulated in HCC tissues and the expression of PD-L1 was regulated by MIAT. MIAT negatively regulated miR-411-5p expression, upregulated STAT3 and ultimately increased PD-L1 expression from the transcription level. The inhibition of miR-411-5p reversed STAT3 and PD-L1 expression inhibited by MIAT knockdown in HCC cells. Yes The knockdown of MIAT enhanced the cytotoxicity of T cells on HCC cells. 35429078 MIAT LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cell lines interaction[miR-330-5p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay Our data showed that the expression of lncRNA MIAT was remarkably increased in human epithelial ovarian cancer tissues and cell lines (p < 0.05). Moreover, we revealed that MIAT might function as an endogenous miR-330-5p sponge to regulate the target gene of miR-330-5p in epithelial ovarian cancer progression. High MIAT expression was associated with poor overall survival of epithelial ovarian cancer patients (p < 0.05). Yes Function assays showed that knockdown of MIAT expression significantly inhibited epithelial ovarian cancer cell proliferation and promoted cell apoptosis in vitro (p < 0.05). 30393480 MIAT LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and ovarian cancer cells interaction[ Sponging miR-150-5p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay lncRNA CASC2 was found to be downregulated, while IL‑17 was upregulated in the plasma of RA patients when compared with these levels in the plasma of healthy controls. MIAT acts as an oncogene in ovarian cancer cells through sponging miR-150-5p. Yes In OVCAR3 and SKOV3 cells, overexpression of MIAT promoted, and knockdown of MIAT suppressed the cell growth, migration, invasion, and EMT. 32186927 MIAT LncRNA Homo sapiens Osteosarcoma Osteosarcoma tissues Interaction[binds miR-150-5p to regulate ZEB1] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay It has been identified that during the development of osteosarcoma, MIAT is upregulated in tumor tissues compared to adjacent non-tumor tissues. These findings indicate that MIAT functions by competing with critical RNAs to target miR-150-5p and activate zinc finger E-box binding homeobox 1 to modulate the function of osteosarcoma cells. Together, the present findings may contribute to the understanding of the pathogenesis of osteosarcoma. Yes The spreading and proliferation of osteosarcoma cells was reduced by MIAT knockdown. 30655889 MT1JP LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Expression[lower expressed] Western Blot//CCK8//Luciferase Report Assay//PCR//Colony Formation Assay//Invasion Assay Here, we found that MT1JP expression was significantly down-regulated in breast cancer tissues and cell lines Here, we found that MT1JP expression was significantly down-regulated in breast cancer tissues and cell lines, and that decreased MT1JP expression was associated with breast cancer progression and poor survival of breast cancer patients. Yes we found that overexpression of MT1JP in breast cancer cells significantly inhibited cell proliferation and invasion 30787983 hsa_circ_0025033 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissue,cell lines (TPC-1, K1, SW579, FTC-133) Interaction[miR-1231 and miR-1304] CCK8//qRT-PCR//Luciferase Report Assay//Microarray The data demonstrated that circ_0025033 level was markedly enhanced in PTC tissues relative to the non-tumorous counterparts (Fig. 1B), which was consistent with the results from circRNA microarray. The Expression[Expression[up-expression]-expression]regulation of circ_0025033 was further confirmed in four cell lines compared with normal thyroid cell (Fig. 1C).circ_0025033 could directly sponge miR-1231 and miR-1304 in PTC cells. Furthermore, the oncogenic role of circ_0025033 is dependent on its sExpression[Expression[up-expression]-expression]pression of miR-1231 and miR-1304. Collectively, this work uncovers a novel signal of circ_0025033/miR-1231/miR-1304 involved in PTC initiation and progression. Yes The data showed that Expression[down-expression]regulation of circ_0025033 in K1 cells resulted in remarkably decreased cell growth and clonogenic ability. Conversely, overexpression of circ_0025033 in TPC-1 cell significantly increased cell viability and clone forming potential (Fig. 2C and D). 30709584 MIR210HG LncRNA Homo sapiens Hepatoblastoma hepatoblastoma tissues and cell lines Interaction( microRNA-608-FOXO6 axis) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay MIR210HG was shown to be highly expressed in hepatoblastoma tissues and cell lines.MIR210HG competitively combined with miR-608, and miR-608 decreased FOXO6 expression. Yes Knockdown of MIR210HG reduced proliferation, migration, and invasion in liver cancer cells, and suppressed tumor growth in vivo. 34918962 MIR210HG LncRNA Homo sapiens Endometrial Neoplasms endometrial cancer tissues Interaction(miR-337-3p/137 via the HMGA2-TGF-β/Wnt pathway) In Vivo Experiment//cell invasion assay//Western Blot//ISH//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay Herein, we show that MIR210HG is overexpressed in endometrial cancer tissues, which is associated with poor prognosis. Mechanistically, bioinformatics analyses, RNA binding protein immunoprecipitation (RIP) assays, and luciferase assays showed that MIR210HG acts as a molecular sponge of miR-337-3p and miR-137 to regulate the expression of HMGA2. Additionally, MIR210HG overexpression significantly enriched the Wnt/β-catenin and TGF-β/Smad3 signaling pathway genes, while MIR210HG or HMGA2 knockdown suppressed the Wnt/β-catenin and TGF-β/Smad3 signaling pathway. Yes MIR210HG silencing significantly inhibited proliferation, migration, invasion, and EMT phenotype formation in vitro as well as tumorigenesis in vivo. 34094710 MKLN1-AS LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression(highly expressed) qRT-PCR In this study, we observed noticeable increased levels of MKLN1-AS in HCC tissues. This upregulation of MKLN1-AS was clinically associated with vascular invasion and decreased disease-free survival and overall survival of patients with HCC. Yes Functionally, MKLN1-AS-knockdown dramatically suppressed the metastasis and growth of HCC cells in vitro and in vivo. 35579449 MKLN1-AS LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[MKLN1-AS/miR-654-3p/HDGF axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay MKLN1?AS was upregulated in HCC tissues and cell lines, and a high MKLN1?AS expression was associated with shorter overall survival and disease?free survival in patients with HCC. Therefore, the MKLN1‑AS/miR‑654‑3p/HDGF axis may offer a novel target for the diagnosis, prognosis, prevention and treatment of HCC. MKLN1?AS was upregulated in HCC tissues and cell lines, and a high MKLN1?AS expression was associated with shorter overall survival and disease?free survival in patients with HCC. Yes Functionally, the knockdown of MKLN1?AS impaired HCC cell proliferation, migration and invasion, as well as induced cell apoptosis in vitro. Knockdown of MKLN1?AS expression also inhibited cell proliferation in vivo. 33000222 MSTO2P LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(CDKN1A/EZH2) Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Colony Formation Assay MSTO2P expression was upregulated in CRC tissues and cells. Besides, MSTO2P epigenetically down-regulated cyclin-dependent kinase inhibitor 1A (CDKN1A) via binding to the enhancer of zeste homolog 2 (EZH2) in the nucleus. At last, rescue experiments proved the anti-tumor effect of inhibition of MSTO2P was partially recovered due to the knockdown of CDKN1A in HT-29 cells. Yes Functional experiments revealed that inhibition of MSTO2P suppressed HT-29 and SW480 cell proliferation and invasion, and promoted cell cycle arrest and cell apoptosis. 35346226 NEK6 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-382-5p/BCAS2 ) RNA Pull-Down//Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ_NEK6 expression was highly expressed in NSCLC tissues and cells. Circ_NEK6 sequestered miR-382-5p to fortify the expression of breast carcinoma amplified sequence 2 (BCAS2) in NSCLC. Besides, BCAS2 had tumor-promoting function in NSCLC. Furthermore, the effects of down-regulated circ_NEK6 on the malignant behaviors of NSCLC cells were totally recovered by miR-382-5p inhibition or BCAS2 overexpression. Yes Functionally, the silencing of circ_NEK6 could effectively suppress NSCLC cell proliferation, migration and invasion. 34663267 circPVT1 CircRNA Homo sapiens esophageal carcinoma EC tissues and cancer cell lines Expression[highly expressed] qRT-PCR//Western Blot//Transwell Assay In the present study, we demonstrated a significant up-regulation of circPVT1 levels in EC tissues and cancer cell lines. Yes In addition, overexpressing circPVT1 in TE-10 cell promoted invasive ability of cancer cell. In contrast, siRNA knockdown of circPVT1 inhibited this phenomenon, leading to increased apoptosis levels of TE-10 cell. 31636510 circPDE3B CircRNA Homo sapiens esophageal carcinoma ESCC tissues Interaction(miR-4766-5p/LAMA1 axis) In Vivo Experiment//Western Blot//Colony Formation Assay//qRT-PCR//RIP//Luciferase Report Assay//IHC//Transwell Assay Here, we screened human circRNA expression profiles in ESCC tissues and found significantly increased expression of hsa_circ_0000277 (termed circPDE3B) in ESCC tissues and cell lines compared to the normal controls. Mechanistically, bioinformatics analysis, a dual-luciferase reporter assay, and anti-AGO2 RNA immunoprecipitation showed that circPDE3B could act as a competing endogenous RNA (ceRNA) by harboring miR-4766-5p to eliminate the inhibitory effect on the target gene laminin α1 (LAMA1). Moreover, higher circPDE3B expression in patients with ESCC was correlated with advanced tumor-node-metastasis (TNM) stage and dismal prognosis. Yes Functional experiments demonstrated that circPDE3B promoted the tumorigenesis and metastasis of ESCC cells in vitro and in vivo. 34226522 hsa_circ_0006948 CircRNA Homo sapiens esophageal carcinoma EC tissues and cells Interaction(miR-4262/FNDC3B axis.) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0006948 was upregulated in EC tissues and cells. Target analysis indicated that miR-4262 was a target for circ_0006948 and FNDC3B was a downstream gene for miR-4262. Yes Downregulating the expression of circ_0006948 or FNDC3B repressed cell growth, migration, invasion and EMT in EC cells. 33630215 MKLN1-AS LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues and cells Regulation(YAP1 ) qRT-PCR MKLN1-AS and YAP1 were overexpressed in hepatocellular carcinoma tissues and cells. MKLN1-AS positively modulated YAP1 expression through targeting and stabilizing YAP1 mRNA.MKLN1-AS was predominantly located in the cytoplasm of the cells. The up-regulation of MKLN1-AS contributed to the poor prognosis of patients with hepatocellular carcinoma. Yes MKLN1-AS intensified proliferation, migration and invasion of hepatocellular carcinoma cells via YAP1. MKLN1-AS also caused hepatocarcinogenesis through inducing YAP1 expression in vivo. 33878313 NEAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[miR-138/SLC38A1 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay The expression of NEAT1 and SLC38A1 was upregulated in CRC tissues and cells.These studies disclosed that NEAT1 knockdown inhibited CRC progression by miR-138/SLC38A1 axis, providing an underlying target for CRC treatment. Yes NEAT1 knockdown or SLC38A1 downregulation restrained cell proliferation and invasion, and accelerated cell apoptosis and autophagy of CRC cells. 32700988 MSTO2P LncRNA Homo sapiens Lung Neoplasms LCa tissues Interaction[up-regulating EZH2] CCK8//qRT-PCR The qRT-PCR results showed that MSTO2P expression in LCa tissues was remarkably higher than that in adjacent tissues. At the same time, EZH2 expression in LCa tissues was also remarkably up-regulated relative to adjacent tissues, and it was positively correlated with the expression of MSTO2P. In addition, after down-regulating MSTO2P, the EZH2 level was also remarkably reduced. Further experimental results revealed that EZH2 down-regulation could impair the cell proliferation ability and down-regulate the expressions of autophagy genes such as Agt5, LC-3I, and LC-3II. Yes After down-regulating MSTO2P, the cell proliferation ability was weakened, and the protein levels of autophagy-related genes including Agt5, LC-3I, and LC-3II were remarkably down-regulated. 31081092 MSRB3-AS1-207 LncRNA Homo sapiens Thyroid Neoplasms PTC tissues Interaction[MAPK signalling] qRT-PCR Higher ENS-653 expression was observed in PTC tissue samples versus adjacent normal tissues, and was associated with a larger tumor size and a more advanced clinical stage. ENS-653 downregulation also inactivated ERK1/2 and ERK5, causing partial MAPK cascade suppression. Higher ENS-653 expression was observed in PTC tissue samples versus adjacent normal tissues, and was associated with a larger tumor size and a more advanced clinical stage. Yes Furthermore, ENS-653 downregulation reduced the proliferation of PTC cells and led to G1-S arrest, but had no impact on apoptosis. 30940124 circATIC CircRNA Homo sapiens Multiple Myeloma MM patients and cell lines Interaction(miR-324-5p/HGF) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Bioinformatics Analysis CircATIC expression was upregulated in MM patients and cell lines. MiR-324-5p was a target of circATIC. CircATIC silencing-mediated effects in MM cells were largely overturned by the knockdown of miR-324-5p. HGF was a target of miR-324-5p, and circATIC upregulated the expression of HGF partly through sponging miR-324-5p in MM cells. MiR-324-5p suppressed the malignant behaviors of MM cells, which were largely counteracted by the overexpression of HGF in MM cells. Yes CircATIC interference notably hampered cell proliferation, migration, invasion, and glycolysis and induced cell apoptosis of MM cells. 35579772 circATIC CircRNA Homo sapiens esophageal carcinoma ESCA tissues and cells Interaction( miR-10-3p/RHCG) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircATIC was decreased in ESCA. Functionally, circATIC served as the sponge for miR-10b-3p, which directly targeted RHCG. MiR-10b-3p elevation reversed circATIC-mediated effect on ESCA cell progression. Moreover, miR-10b-3p inhibition suppressed cell growth and metastasis and enhanced radiosensitivity in ESCA cells by targeting RHCG. Yes CircATIC overexpression suppressed cell proliferation, migration and invasion and promoted radiosensitivity and apoptosis in ESCA cells in vitro and repressed tumor formation and radioresistance in vivo. 35307984 NEAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC cell lines regulation[miR-205-5p/VEGFA axis] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//RIP//Transwell Assay Our results demonstrated high expression of NEAT1 and VEGFA and low expression of miR-205-5p in CRC cell lines. Taken together, lncRNA NEAT1 was found to be upregulated in CRC cell lines, promoting CRC cell proliferation, migration, and invasion through regulating the miR-205-5p/VEGFA signaling pathway. Yes Moreover, downregulation of NEAT1 and VEGFA inhibited cell proliferation, migration, and invasion. 32065361 hsa_circ_0003489 CircRNA Homo sapiens Multiple Myeloma MM tissues and cells Interaction(miR-433-3p/PBX3 axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//cell invasion assay//Colony Formation Assay Circ_0003489 and PBX3 were upregulated, while miR-433-3p was downregulated in MM tissues. In terms of mechanism, circ_0003489 could sponge miR-433-3p to regulate PBX3. Besides, miR-433-3p downregulation or PBX3 overexpression reversed the inhibition effect of circ_0003489 knockdown on MM progression. Yes Circ_0003489 knockdown or miR-433-3p overexpression remarkably suppressed MM proliferation and increased apoptosis in vitro. 36004524 MKLN1-AS LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(SOX9) qRT-PCR Both MKLN1-AS and SOX9 were up-regulated in HCC tissues compared to paracancerous tissues. Overexpression of SOX9 increased MKLN1-AS in HCCs, whereas silencing SOX9 decreased MKLN1-AS expression. According to dual luciferase reporter and ChIP assays, SOX9 can bind to the promoter of MKLN1-AS gene to stimulate the expression. MKLN1-AS is transcriptionally regulated by SOX9 and mediates the effects of SOX9 on the proliferation and EMT of HCCs. Yes SOX9 promoted cell viability, proliferation, invasion, and EMT of HCCs, but these promoting effects of SOX9 were attenuated after the knockdown of MKLN1-AS. 35138470 hsa_circ_0005230 CircRNA Homo sapiens Cholangiocarcinoma CCA tissues,cell line Interaction[sponging miR-1238 and miR-1299] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay As data showed, circ_0005230 was elevated in tumors and CCA cells. As data showed, circ_0005230 was elevated in tumors and CCA cells. Its expression in tumor samples was related to clinical severity. Yes Functionally, circ_0005230 significantly facilitated cell growth, clone-forming ability and metastatic properties and inhibit cell apoptosis in CCA cells. The in vivo study further validated the in vitro results. 30946694 NF1-419 CircRNA Homo sapiens Astrocytoma U87 cells Regulation Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay U87-NF1-419 can promote cell apoptosis and regulate lipid metabolism through glycerophospholipid metabolism and retrograde endocannabinoid signaling. In vivo experiments showed that circNF1-419 inhibits tumor growth in BALB/C nude mice, and enhanced AKAP4 and PTDSS1 in tumor tissues. Yes U87-NF1-419 can promote cell apoptosis and regulate lipid metabolism through glycerophospholipid metabolism and retrograde endocannabinoid signaling. In vivo experiments showed that circNF1-419 inhibits tumor growth in BALB/C nude mice, and enhanced AKAP4 and PTDSS1 in tumor tissues. 34376137 NEAT1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cell lines Interaction( miR-486-5p / NR4A1/Wnt/β-catenin signaling pathway.) CCK8//qRT-PCR//Western Blot We found NEAT1 and NR4A1 were highly expressed in colorectal cancer tissues and cell lines compared with controls. The gain of NR4A1 could abolish NEAT1 silencing-induced effects in colorectal cancer cells. In addition, NEAT1 contributed to colorectal cancer progression through mediating NR4A1/Wnt/β-catenin signaling pathway. Yes Loss-functional experiments revealed that knockdown of NEAT1 or NR4A1 repressed proliferation and motility, while inducing apoptosis of colorectal cancer cells. 33337350 MST1P2 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Interaction(microRNA miR-133b) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//migration assay//Cell Apoptosis Assay//Luciferase Report Assay//Cell Proliferation Assay//IHC//Invasion Assay We found that Lnc MST1P2 is obviously overexpression in CC tissues and cells. Dual-Luciferase assay and RT-qPCR assay further proved that Lnc MST1P2 has a negative regulation to miR-133b. miR-133b up-regulation inhibited cell viability and metastasis of Hela and SIHA cells. miR-133b inhibition notably decreased the anti-cancer effect of si-Lnc MST1P2. Yes Si-Lnc MST1P2 obviously repressed cell growth, cell migration, and cell invasion in Hela and SIHA cells. Moreover, Si-Lnc MST1P2 suppressed CC tumorigenesis in vivo. 34034626 NEF LncRNA Homo sapiens Thyroid Cancer, Papillary blood Interaction[TGF-β1] qRT-PCR High levels of TGF-β1 mRNA and low levels of lncRNA-NEF were also detected in the serum of patients with PTC compared with in healthy controls. In conclusion, the present study suggested that TGF-β1 may promote the invasion and migration of PTC cells by inhibiting the expression of lncRNA-NEF. Yes Furthermore, TGF-β1 promoted cell migration and invasion of PTC cell lines, but not the normal cell line, whereas lncRNA-NEF overexpression inhibited these phenomena. 30867742 MNX1-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LAC tissues and cell line Interaction(miR-34a/SIRT1 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay MNX1-AS1 was up-regulated in LAC, and over-expression of MNX1-AS1 was significantly associated with lymph node metastasis and poor prognosis. Mechanistically, MNX1-AS1 served as a ceRNA of miR-34a to down-regulate miR-34a expression. SIRT1 is targeted by miR-34a and its expression is regulated by MNX1-AS1 and miR-34a. Up-regulation of SIRT1 salvaged the effect of silencing MNX1-AS1 on A549 and H1299 cells, to some extent. These results showed that MNX1-AS1 contributes to LAC progression by targeting the miR-34a/SIRT1 axis. MNX1-AS1 was up-regulated in LAC, and over-expression of MNX1-AS1 was significantly associated with lymph node metastasis and poor prognosis. Yes In A549 and H1299 cells, cell proliferation, migration, and invasion were suppressed, the cell cycle was regulated, as well as apoptosis was increased after silencing MNX1-AS1. 35958481 MNX1-AS1 LncRNA Homo sapiens Non-alcoholic Fatty Liver Disease LO2 cells Regulation(YAP) In Vivo Experiment//qRT-PCR//Oil Red O Staining//Western Blot In conclusion, these data suggested that inhibition of MAYA could up-regulate YAP, which might repress hepatocyte senescence through modulating iron overload Yes Of importance, depression of lncRNA MAYA (MAYA) reduced iron overload and cellular senescence via promotion of YAP in PA-treated hepatocytes. These effects were further supported by in vivo experiments. 34190396 hsa_circ_0043898 CircRNA Homo sapiens esophageal carcinoma esophageal carcinoma specimens Expression[lower expressed] Flow Cytometry//qRT-PCR//Colony Formation Assay circ0043898 was validated that down-regulated expressed in the specimens from the patients with esophageal carcinoma. Yes The cell assays proved that overexpression of circ0043898 can obviously inhibit the cell proliferation, cell migration and invasion and induce cell apoptosis and death in the cancerous cells. 30252576 NEF LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma tumor tissues Regulation[wnt/β-catenin pathway] CCK8//qRT-PCR//Western Blot//Transwell Assay Expression of NEF was significantly downregulated in tumor tissues than in adjacent tissues in most patients.LncRNA NEF may inhibit the proliferation, migration and invasion of esophageal squamous-cell carcinoma cells by inactivating with wnt/β-catenin pathway. Serum level of NEF was higher in esophageal squamous-cell carcinoma patients than in healthy controls, and was significantly correlated with tumor size and tumor distant tumor metastasis. Yes NEF overexpression inhibited cancer cell proliferation, migration and invasion. 30402846 NEF LncRNA Homo sapiens Glioma glioma Tissue Interaction[miR-548g,YBX4] qRT-PCR//ELISA//Western Blot It was determined that NEF expression was Expression[down-expression]regulated in tumor tissues compared with adjacent heathy tissues. Blood NEF levels were negatively correlated with blood transforming growth factor (TGF)-β1 levels in patients with distant tumor metastasis, but not in patients with non-metastatic glioma and healthy controls. Yes NEF overexpression inhibited cancer cell migration and invasion. In addition, NEF overexpression Expression[down-expression]regulated TGF-β1 expression. 31258706 MNX1-AS1 LncRNA Homo sapiens Gallbladder Neoplasms GBC cells and tissues Interaction(MNX1-AS1/IGF2BP3/Hippo pathway ) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//RIP//RNA-seq//Luciferase Report Assay//Invasion Assay//ChIP This study shows that MNX1-AS1 expression is elevated in the tissues of GBC patients, and is strongly associated with reduced patient survival. Mechanistically, MNX1-AS1 is transcriptionally activated by TEA domain family member 4 (TEAD4), and suppresses insulin-like growing factor 2 mRNA-binding protein 3 (IGF2BP3) degradation by recruiting ubiquitin specific peptidase 16 (USP16). Furthermore, MNX1-AS1/IGF2BP3 axis inhibits the Hippo signaling pathway and subsequently activates TEAD4, thereby forming a positive feedback loop. This study shows that MNX1-AS1 expression is elevated in the tissues of GBC patients, and is strongly associated with reduced patient survival. Yes Functionally, MNX1-AS1 significantly stimulates the proliferation and metastasis of GBC cells in vitro and in vivo. 35953000 MNX1-AS1 LncRNA Homo sapiens Cholangiocarcinoma ICC cell lines and tissues regulation[MNX1-AS1/c-Myc and MAZ/MNX1/Ajuba/Hippo pathway] ChIP//Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RIP//FISH//IHC//Transwell Assay By cytological and animal model experiments, this study demonstrated that the expression of lncRNA MNX1-AS1 was remarkably elevated in ICC cell lines and tissues, and was highly and positively correlated with motor neuron and pancreas homeobox protein 1 (MNX1) expression. Taken together, our results uncovered that MNX1-AS1 can facilitate ICC progression via MNX1-AS1/c-Myc and MAZ/MNX1/Ajuba/Hippo pathway, suggesting that MNX1-AS1 may be able to serve as a potential target for ICC treatment. Yes MNX1-AS1 significantly facilitated the proliferation, migration, invasion, and angiogenesis in ICC cells in vitro, and remarkably promoted tumor growth and metastasis in vivo. 33093444 MNX1-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tumor tissues interaction[ p-JAK and Stat3] qRT-PCR//RNA Pull-Down//RIP//Western Blot We found that MNX1-AS1 were upregulated in TNBC tumor tissues and correlated with poor survival outcome in TNBC patients.By using RNA pulldown assay followed by western blotting and RNA immunoprecipitation (RIP), we identified Stat3 was the MNX1-AS1 binding protein and MNX1-AS1 upregulated the phosphorylation of Stat3 by enhancing the interaction between p-JAK and Stat3. We found that MNX1-AS1 were upregulated in TNBC tumor tissues and correlated with poor survival outcome in TNBC patients. Yes Silencing MNX1-AS1 reduced the aggressiveness of TNBC in vitro and in vivo. 32754442 MNX1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissue Interaction(microRNA-370/FoxM1 ) In Vivo Experiment//RNA Pull-Down//Migration Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay We demonstrated remarkably elevated levels of MNX1-AS1 in the LSCC tissues, which was correlated with poor disease prognosis. We also demonstrated that MNX1-AS1 sequesters that activity of miR-370, thereby releasing Forkhead Box ml (FoxM1) from the inhibitory actions of MNX1-AS1. Furthermore, the positive correlation of MNX1-AS1 and FoxM1 as well as the converse correlation between miR-370 and MNX1-AS1 (or FoxM1) were revealed in LSCC tissues using experiments. We demonstrated remarkably elevated levels of MNX1-AS1 in the LSCC tissues, which was correlated with poor disease prognosis. Yes MNX1-AS1-silencing strongly suppressed LSCC cell proliferation, migration, and invasion. Moreover, knockdown of MNX1-AS1 retarded tumor growth in nude mice model. 33882027 MNX1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck human LSCC tissues Interaction(mir-744-5p/bcl9/β-Catenin Axis) In Vivo Experiment//Western Blot//qRT-PCR//RIP//MTT//IHC//Transwell Assay MNX1-AS1 level was increased significantly in human LSCC tissues as compared with the normal tissues, which showed a positive correlation with BCL9 level while a negative correlation with miR-744-5p level. miR-744-5p targeted upregulation weakened the luciferase activity of MNX1-AS1 and /BCL9, and downregulated their expression levels-wt, while showed no effect when the binding sites were mutated. Collectively, this study reveals that MNX1-AS1 contributes to cell growth and migration by regulating miR-744-5p/BCL9/β-catenin axis in LSCC. High level of MNX1-AS1 predicted a poor prognosis and an advanced clinical process in LSCC patients. Yes Knockdown of MNX1-AS1 markedly weakened cell viability, migration, and invasion abilities, while BCL9 overexpression abolished these tendencies. In addition, MNX1-AS1 downregulation induced decreases in tumor volumes and weights in vivo, accompanied by reductions in BCL9, Ki-67 and β-catenin expression and an increase in miR-744-5p expression. 33821684 NEAT1 LncRNA Homo sapiens Colorectal Neoplasms Interaction[sponging miR-193a-3p] Flow Cytometry//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Upregulation of NEAT1 expression was significantly correlated with TNM stage, poor survival and tumour recurrence in patients with CRC, and acted as an independent prognostic factor for tumour recurrence. Knockdown of NEAT1 suppressed cell proliferation, colony formation abilities and invasive potential and induced cell apoptosis, but overexpression of NEAT1 reversed these effects. Upregulation of NEAT1 expression was significantly correlated with TNM stage, poor survival and tumour recurrence in patients with CRC, and acted as an independent prognostic factor for tumour recurrence. Yes Knockdown of NEAT1 suppressed cell proliferation, colony formation abilities and invasive potential and induced cell apoptosis, but overexpression of NEAT1 reversed these effects. 30407674 circSKA3 CircRNA Homo sapiens Medulloblastoma MB tissues regulation[miR-383-5p/FOXM1 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The levels of circSKA3 and FOXM1 were significantly elevated, while the level of miR-383-5p was notably declined in MB tissues. CircSKA3 augmented MB progression partly through miR-383-5p/FOXM1 axis. Yes CircSKA3 silencing impeded cell proliferation, migration, and invasion while promoted apoptosis by targeting miR-383-5p in vitro and retarded xenograft tumor growth in vivo. 33408514 MNX1 LncRNA Homo sapiens Urinary Bladder Neoplasms Regulation[miR-218-5p/RAB1A Axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//IF//Luciferase Report Assay//IHC//Transwell Assay ur study demonstrates that long noncoding RNA MNX1-AS1 promotes the initiation and progression of bladder cancer. MNX1-AS1 regulates RAB1A expression to promote proliferation, migration, invasion, and epithelial-mesenchymal transitions of bladder cancer cells via miR-218-5p, which contributes to the tumor growth and metastasis of bladder cancer. Yes Reduced expression of MNX1-AS1 could suppress cell proliferation, migration, invasion, and epithelial-mesenchymal transition in bladder cancer cells, whereas overexpression of MNX1-AS1 resulted in the opposite effects. Furthermore, in vivo experiments revealed that reduced expression of MNX1-AS1 inhibited tumor growth and metastasis. 31843814 circSKA3 CircRNA Homo sapiens Medulloblastoma MB tissues and cells Interaction(miR-326/ID3) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ-SKA3 expression was elevated in MB tissues and cells. Mechanism analyses revealed that circ-SKA3 directly targeted miR-326 that could bind to ID3, and circ-SKA3 decoyed miR-326 to increasing ID3 expression. Rescue experiments showed that miR-326 inhibition reversed the effects of circ-SKA3 knockdown, and ID3 overexpression recovered MB cell proliferation, migration and invasion blocked by miR-326 restoration. Yes Depleted expression of circ-SKA3 inhibited MB cell proliferation, migration and invasion and induced apoptosis and cell cycle arrest, and circ-SKA3 knockdown inhibited MB growth in vivo. 33775353 hsa_circ_0001821 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Regulation( miR-526b-5p/GRK5 axis) In Vivo Experiment//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The results presented that the expression of circ_0001821 and GRK5 was increased, while miR-526b-5p expression was decreased in NSCLC tissues and cells. Circ_0001821 knockdown reduced colony formation ability and metastasis ability but enhanced TAX sensibility and apoptosis of NSCLC cells, which was attenuated by miR-526b-5p inhibition or GRK5 overexpression. Circ_0001821 targeted miR-526b-5p, and miR-526b-5p targeted GRK5. Circ_0001821 could upregulate GRK5 expression by sponging miR-526b-5p. Depletion of circ_0001821 also blocked tumor growth in vivo. In conclusion, the depletion of circ_0001821 inhibited NSCLC progression, at least in part, by modulating the miR-526b-5p/GRK5 axis. Yes irc_0001821 knockdown reduced colony formation ability and metastasis ability but enhanced TAX sensibility and apoptosis of NSCLC cells, which was attenuated by miR-526b-5p inhibition or GRK5 overexpression. 34219377 hsa_circ_0000142 CircRNA Homo sapiens Multiple Myeloma MM patients Interaction(miR-610/AKT3 axis) Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay In this study, it was demonstrated that, circ_0000142 was highly expressed in MM patients, and its high expression level was significantly associated with increased International Staging System and Durie-Salmon stage.Mechanistically, circ_0000142 functioned as a competitive endogenous RNA, directly targeting miR-610 and positively regulating AKT3 expression. Yes Overexpression of circ_0000142 enhanced MM cell proliferation, migration, invasion and suppressed cell apoptosis, while knocking down circ_0000142 had the opposite effects. 32970816 NEAT1 LncRNA Homo sapiens Colorectal Neoplasms cell lines Interaction[ sponge miR-495-3p] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay As we observed, NEAT1 level was obviously elevated in colon cancer cells. Interestingly, as exhibited, miR-495-3p was obviously decreased in colon cancer cells and it significantly suppressed colon cancer progression. Subsequently, miR-495-3p was predicted as a target of NEAT1. CDK6 was speculated as the target of miR-495-3p and miR-495-3p modulated its expression negatively. Finally, it was indicated that NEAT1 promoted colon cancer development through modulating miR-495-3p and CDK6 in vivo. Taken these together, we reported that NEAT1 could sponge miR-495-3p to contribute to colon cancer progression through activating CDK6. Yes As exhibited, silence of NEAT1 could greatly repress colon cancer cell progression. Apoptosis of colon cancer cells was triggered and the cell cycle progression was remarkably inhibited by downregulation of NEAT1. 31173354 circCHEK1_246aa CircRNA Homo sapiens Multiple Myeloma MM cells Expression(highly expressed) In Vivo Experiment//Western Blot//Transfection//Co-IP//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay//IF We demonstrated that CHEK1 expression was significantly increased in human MM samples relative to normal plasma cells, and that in MM patients, high CHEK1 expression was associated with poor outcomes. Increased CHEK1 expression induced MM cellular proliferation and evoked drug-resistance in vitro and in vivo. CHEK1-mediated increases in cell proliferation and drug resistance were due in part to CHEK1-induced CIN. CHEK1 activated CIN, partly by phosphorylating CEP170. Interestingly, CHEK1 promoted osteoclast differentiation by upregulating NFATc1 expression. Intriguingly, we discovered that MM cells expressed circCHEK1_246aa, a circular CHEK1 RNA, which encoded and was translated to the CHEK1 kinase catalytic center. Transfection of circCHEK1_246aa increased MM CIN and osteoclast differentiation similarly to CHEK1 overexpression, suggesting that MM cells could secrete circCHEK1_246aa in the BM niche to increase the invasive potential of MM cells and promote osteoclast differentiation. and that in MM patients, high CHEK1 expression was associated with poor outcomes. Yes Increased CHEK1 expression induced MM cellular proliferation and evoked drug-resistance in vitro and in vivo. 34090465 hsa_circ_0000463 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-924/SLC1A5 signaling) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Invasion Assay//Flow Cytometry//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay Circ_0000463 expression was elevated in NSCLC tissues and cell lines. circ_0000463 absence suppressed the glutamine metabolism of NSCLC cells by targeting miR-924/SLC1A5 axis. Yes Circ_0000463 knockdown suppressed the proliferation, migration, and invasion and promoted the apoptosis of NSCLC cells. Circ_0000463 knockdown suppressed xenograft tumor growth in vivo. 34811815 NEAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[miR-195-5p] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expression of NEAT1 was up-regulated in CRC tissues and cells, and overall survival was lower with high expression of NEAT1. NEAT1 promotes colorectal cancer cellular processes by regulating CEP55 expression via the sponging of miR-195-5p. The expression of NEAT1 was up-regulated in CRC tissues and cells, and overall survival was lower with high expression of NEAT1. Yes Knockdown of NEAT1 repressed cell proliferation, migration, and invasion, while inducing apoptosis in CRC cells. 32749120 NEAT1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cells Interaction(miR-448/ZEB1 ) CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay Long noncoding RNA-nuclear paraspeckle assembly transcript 1 was up-regulated in colorectal cancer tissues and cells. Knocking down of nuclear paraspeckle assembly transcript 1 can suppress colorectal cancer proliferation and invasion, and caused a reduction of ZEB1 expression and an increase of miR-448 expression. Furthermore, knockdown of nuclear paraspeckle assembly transcript 1 regulated miR-448/ZEB1 axis to inhibit the expression of ZEB1. miR-448 silencing can reverse the effect of nuclear paraspeckle assembly transcript 1 knockdown. Yes Knocking down of nuclear paraspeckle assembly transcript 1 can suppress colorectal cancer proliferation and invasion, and caused a reduction of ZEB1 expression and an increase of miR-448 expression. 35695254 circHIPK3 CircRNA Homo sapiens Cholangiocarcinoma CCA tissues ,cell lines,blood Expression[highly expressed] qRT-PCR In this work, the expression of circular RNA circ-0000284 (aka circHIPK3) was specifically elevated in CCA cell lines, human tumor tissues and plasma exosomes. Yes Increased expression of circ-0000284 was associated with enhanced migration, invasion and proliferation of CCA cell lines. 31654054 circLAMP1 CircRNA Homo sapiens Cholangiocarcinoma CCA tissue samples and cell lines Interaction(miR-556-5p and miR-567/YY1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Up-regulation of circ-LAMP1 was found in CCA tissue samples and cell lines. Mechanistically, circ-LAMP1 directly sponged miR-556-5p and miR-567, thereby releasing their suppression on YY1 at post-transcriptional level. Rescue assay indicated that the oncogenic role of circ-LAMP1 is partially dependent on its modulation of YY1 in CCA. Enhanced level of circ-LAMP1 was linked to clinical severity, high post-operative recurrence and poor prognosis for the patients with CCA. Yes Gain/loss-of-function assays confirmed the oncogenic role of circ-LAMP1 in mediating cell growth, apoptosis, migration and invasion. Nevertheless, the level of circ-LAMP1 had no effect on normal biliary epithelium proliferation and apoptosis. Animal study further verified the in vitro data. 33675150 MIR99AHG LncRNA Homo sapiens Mycobacterium tuberculosis peripheral blood mononuclear cells from active TB patients Expression(highly expressed) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//RNA-seq//Cell Apoptosis Assay In this study, we identify an immunoregulatory long intergenic noncoding RNA, lincRNA-MIR99AHG, which is upregulated in mouse and human macrophages upon IL-4/IL-13 stimulation and downregulated after clinical Mtb HN878 strain infection and in peripheral blood mononuclear cells from active TB patients. Yes Knockdown of lincRNA-MIR99AHG with ASOs significantly reduced intracellular Mtb growth in mouse and human macrophages and reduced pro-inflammatory cytokine production. In addition, in vivo treatment of mice with MIR99AHG ASOs reduced the mycobacterial burden in the lung and spleen. 35895506 NIFK-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC patients and cells Interaction(SRSF10) qRT-PCR NIFK-AS1 was highly expressed in HCC tissues and correlated with a poor prognosis in HCC patients (P=0.008). RNA pull-down validated the NIFK-AS1/SRSF10 interaction. The overexpression of NIFK-AS1 was sufficient to rescue the growth of SRSF10 knockdown HepG2 cells. NIFK-AS1 was highly expressed in HCC tissues and correlated with a poor prognosis in HCC patients (P=0.008). Yes NIFK-AS1 was also significantly associated with cell mitosis, the cell cycle, and other biological processes. NIFK-AS1 deletion prevented cell proliferation, induced apoptosis, caused G2/M arrest, and affected cell cycle progression. 36092356 circDNM3OS CircRNA Homo sapiens Cholangiocarcinoma CCA tissues and cells Interaction( miR-145-5p/MORC2) In Vivo Experiment//Wound Healing Assay//Flow Cytometry//qRT-PCR//Colony Formation Assay CircDNM3OS and MORC2 were upregulated while miR-145-5p was downregulated in CCA tissues and cells. CircDNM3OS sponged miR-145-5p to elevate MORC2 expression. MiR-145-5p silencing overturned circDNM3OS knockdown-mediated influence on malignancy and glutamine metabolism of CCA cells. Yes Inhibition of circDNM3OS reduced xenograft tumor growth in vivo and constrained proliferation, colony formation, migration, invasion, induced apoptosis, and reduced glutamine metabolism of CCA cells in vitro. 33628035 NIHCOLE LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Regulation CCK8//RIP//RNA Pull-Down//IF Depletion of NIHCOLE from HCC cells led to impaired proliferation and increased apoptosis. NIHCOLE deficiency led to accumulation of DNA damage due to a specific decrease in the activity of the nonhomologous end-joining (NHEJ) pathway of DSB repair. DNA damage induction in NIHCOLE-depleted cells further decreased HCC cell growth. NIHCOLE was associated with DSB markers and recruited several molecules of the Ku70/Ku80 heterodimer. NIHCOLE expression was associated with poor prognosis and survival of HCC patients. Yes Depletion of NIHCOLE from HCC cells led to impaired proliferation and increased apoptosis. NIHCOLE deficiency led to accumulation of DNA damage due to a specific decrease in the activity of the nonhomologous end-joining (NHEJ) pathway of DSB repair. DNA damage induction in NIHCOLE-depleted cells further decreased HCC cell growth. NIHCOLE was associated with DSB markers and recruited several molecules of the Ku70/Ku80 heterodimer. 34321241 NIHCOLE LncRNA Homo sapiens Breast Neoplasms Breast Cancer tissues regulation[MicroRNA-511-3p/HMGA2 Axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay In this study, LINC02163 was upregulated in breast cancer, and its expression level was closely associated with tumor size, lymph node metastasis, and TNM stage.Our findings add to our understanding of the roles of the LINC02163/miR-511-3p/HMGA2 pathway as a regulator of breast cancer pathogenesis and may be useful in the development of lncRNA-directed cancer diagnosis, prognosis, and therapy. Patients with breast cancer presenting high LINC02163 expression exhibited shorter overall survival than those presenting low LINC02163 expression. Yes Knockdown of LINC02163 resulted in a decrease in breast cancer cell proliferation, migration, and invasion and an increase in cell apoptosis in vitro. In addition, silencing of LINC02163 impeded breast cancer tumor growth in vivo. 32571448 NIHCOLE LncRNA Homo sapiens Stomach Neoplasms GC tissue and cells Interaction(HuR/VAV3 mRNA) Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Colony Formation Assay//Transwell Assay Through bioinformatics analyses and in situ hybridization (ISH), we identified that RP11-138J23.1 was upregulated in GC tissue. Mechanistically, RP11-138J23.1 exerted its oncogenic functions by binding to HuR protein and increasing stability of VAV3 mRNA. Overall, our study highlights the essential role of RP11-138J23.1 in GC, suggesting that RP11-138J23.1 might be a potent therapeutic target for patients with GC. Yes Further study showed that RP11-138J23.1 knockdown significantly inhibited cell proliferation and metastatic ability.Whereas, RP11-138J23.1 overexpression could promote tumor cell growth and metastasis in vitro. 35392234 circZNF609 CircRNA Homo sapiens Cholangiocarcinoma cholangiocarcinoma tissues Interaction(YY1/eIF4A3/circ-ZNF609/miR-432-5p/LRRC1) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay//ChIP In this study, circ-ZNF609 was discovered as a novel circRNA highly expressed in cholangiocarcinoma for the first time. The promoting effect of circ-ZNF609 on cholangiocarcinoma is achieved via oncogene LRRC1 up-regulation through targeting miR-432-5p by endogenous competitive RNA mechanism. In addition, transcription factor YY1 can bind to the promoter of ZNF609 to further facilitate the transcription of circ-ZNF609. RNA binding protein eIF4A3 can bind to the pre-mRNA of circ-ZNF609 which promotes the circ-ZNF609 circular formation. The circ-ZNF609 expression is connected with the advanced TNM stage, lymphatic invasion and survival time in cholangiocarcinoma patients, and can be used as an independent prognostic factor for the patients. Yes Circ-ZNF609 can promote the cholangiocarcinoma cells proliferation, migration and invasion in vitro, it can also catalyze the xenograft growth in vivo. 34898474 NEAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular Peripheral blood mononuclear cells Interaction[miR-155/Tim-3 pathway] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP NEAT1 and Tim-3 were up-regulated in the PBMCs of patients with HCC (n = 20) compared with healthy subjects (n = 20). Down-regulation of NEAT1 restrained CD8T cell apoptosis and enhanced the cytolysis activity, while interference of miR-155 showed the opposite effects by up-regulating Tim-3. Binding and interaction between NEAT1 and miR-155 were validated in CD8T cells. Down-regulation of NEAT1 restrained CD8T cell apoptosis and enhanced the cytolysis activity through the miR-155/Tim-3 pathway. Yes Repression of NEAT1 suppressed tumor growth in HCC mice. 30710754 NKILA LncRNA Rattus norvegicus Ischemic Stroke HT22 cells Regulation(NF-κB pathway) In Vivo Experiment//Western Blot//Tunel//qRT-PCR//ELISA//EdU Staining//IF In in vivo experiments, NKILA significantly reduced cerebral infarction volume, brain water content and neurological score caused by MCAO/R. Moreover, NKILA blocked the activation of the NF-κB pathway, and inhibited astrocyte proliferation and neuron apoptosis as well as inflammation and oxidative stress. In in vitro experiments, NKILA significantly inhibited NF-κB pathway in HT22 cells. In addition, NKILA alleviated the inflammatory response and oxidative stress of U251 cells mediated by HT22 cells after OGD/R, and promoted U251 cell proliferation and inhibit their apoptosis. Yes In in vitro experiments, NKILA significantly inhibited NF-κB pathway in HT22 cells. 34454183 hsa_circ_0000284 CircRNA Homo sapiens Cholangiocarcinoma cholangiocarcinoma cell lines, tissues,blood Expression[highly expressed] Flow Cytometry//qRT-PCR//RIP//FISH//Luciferase Report Assay Circ-0000284 was evidently elevated in cholangiocarcinoma cell lines, tumor tissues and plasma exosomes. Yes Meanwhile, the high expression of circ-0000284 enhanced the migration, invasion and proliferation abilities of cholangiocarcinoma cells in vivo and in vitro 31501232 NEAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Regulation[Let-7b-IGF-1R Axis] qRT-PCR//Western Blot The results showed that the expressions of NEAT1 were significantly increased, while the expressions of miR-let-7b were decreased in the HCC tissues and cell lines.The over-expression of NEAT1 could promote the proliferation of HCC cells by inhibiting the expression of the miR-let-7b regulated by IGF-1R. Yes The mouse model experiments confirmed that the interference with NEAT1 expression inhibited the tumor growth. 31819522 MIR9-3HG LncRNA Homo sapiens lung squamous cell carcinoma LUSC cells Interaction(miR-138-5p/TAF15) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay RT-qPCR was conducted to reveal that MIR9-3HG was observably overexpressed in LUSC cells. Luciferase reporter, RNA-binding protein immunoprecipitation (RIP), immunofluorescence (IF), fluorescent in situ hybridization (FISH) and RNA pull down assays were implemented to confirm that MIR9-3HG modulates LIM domain kinase 1 (LIMK1) mRNA and protein levels by sequestering microRNA-138-5p (miR-138-5p) and recruiting TATA-box binding protein associated factor 15 (TAF15) protein. Yes Functional assays encompassing colony formation, 5-ethynyl-2'-deoxyuridine (EdU) staining, transwell and flow cytometry assays and western blot detecting related proteins demonstrated that MIR9-3HG depletion hampered cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) while accelerating cell apoptosis in LUSC. 35933883 MIR4435-2HG LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Regulation[Wnt/β-catenin signaling] Western Blot//qRT-PCR//Microarray//IHC//Transwell Assay The analysis revealed MIR4435-2HG to be markedly up-regulated in gastric cancer samples compared to normal stomach specimens. Using RNA pull-down and mass-spectrometry analyses we found and verified a direct and novel interaction between MIR4435-2HG and desmoplakin (DSP), the most abundant desmosomal protein. Overexpression and knockdown experiments revealed opposing roles for DSP and MIR4435-2HG, unmasking a cascade through which MIR4435-2HG binds to and inhibits DSP, leading to activation of WNT/β-catenin signaling and epithelial-mesenchymal transition in gastric cancer cells. We propose that the MIR4435-2HG/DSP/WNT axis serves as a critical effector of carcinogenesis and progression of gastric cancer, and could be exploited therapeutically to improve patients' outcomes. Yes Functional experiments showed that MIR4435-2HG up-regulation enhanced gastric cancer cell proliferation, clonogenicity, and migration and invasion in vitro, as well as tumorigenicity in mice. 31484163 NKILA LncRNA Mus musculus Asthma asthmatic mice Regulation(NF-κB pathway) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//ELISA Downregulated NKILA and upregulated total IgE level and expressions of inflammatory cytokines were observed in asthmatic mice. NKILA overexpression alleviated AHR and airway inflammation in asthmatic mice. NKILA reduced macrophage abundance and promoted M2 macrophage polarization in asthmatic mice. NKILA inhibited the NF-κB pathway in asthmatic mice. We highlighted that lncRNA NKILA limited the asthmatic airway inflammation via promoting M2 macrophage polarization and inhibiting the NF-κB pathway. Yes Downregulated NKILA and upregulated total IgE level and expressions of inflammatory cytokines were observed in asthmatic mice. NKILA overexpression alleviated AHR and airway inflammation in asthmatic mice. NKILA reduced macrophage abundance and promoted M2 macrophage polarization in asthmatic mice. NKILA inhibited the NF-κB pathway in asthmatic mice. We highlighted that lncRNA NKILA limited the asthmatic airway inflammation via promoting M2 macrophage polarization and inhibiting the NF-κB pathway. 34303195 hsa_circ_0006677 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and lung cancer cells Interaction(miR-578/SOSC2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis Circ_0006677 expression was reduced in NSCLC tissues of patients and lung cancer cells in comparison to adjacent normal tissues. Mechanically, circ_0006677 could inhibit NSCLC progression and glycolysis by regulating the expression of the signal transducer inhibitor SOSC2 through sponging microRNA-578 (miR-578). Lower expression of circ_0006677 was significantly associated with poorer patient survival. Yes Overexpression of circ_0006677 significantly inhibited the ability of NSCLC cell proliferation, migration, invasion, and glycolysis. 34054537 hsa_circ_0021205 CircRNA Homo sapiens Cholangiocarcinoma CCA tissues Interaction(MiR-204-5p/RAB22A Axis) In Vivo Experiment//Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Invasion Assay//Transwell Assay In this study, we found that circ_0021205 expression was up-regulated in CCA and positively correlated with tumor size and TNM stage. In addition, mechanisms investigation demonstrated that circ_0021205 exerts its oncogenic function by sponging miR-204-5p to regulate the expression of RAB22A. In this study, we found that circ_0021205 expression was up-regulated in CCA and positively correlated with tumor size and TNM stage. Yes The results showed that circ_0021205 promoted the proliferation, migration, and invasion of CCA cells. In vivo experiments showed that circ_0021205 inhibition reduced tumorigenesis in mice. 34012964 MIR4435-2HG LncRNA Homo sapiens Stomach Neoplasms macrophages Regulation(Jagged1/Notch and JAK1/STAT3 pathways) Western Blot//Migration Assay//CCK8//qRT-PCR//IF RT- qPCR and western blot to detect gene and protein level expression, transmission electron microscopy and nanoparticle tracking analysis (NTA) to study the efficiency of exosome isolation, and flow cytometry to observe cell differentiation were employed, delivery of MIR4435-2HG shRNA via MKN45 cell-derived exosomes significantly reversed the MKN45 exosome-induced M2 polarization in macrophages. MIR4435-2HG was negatively correlated with the survival rate of GC patients, and by inhibiting the activity of MIR4435-2HG, the viability and migration ability of GC cells could be reduced. Yes MIR4435-2HG was negatively correlated with the survival rate of GC patients, and by inhibiting the activity of MIR4435-2HG, the viability and migration ability of GC cells could be reduced. 36483041 hsa_circ_0020256 CircRNA Homo sapiens Cholangiocarcinoma CCA cells Interaction(miR-432-5p/E2F3 axis) In Vivo Experiment//Microarray//Western Blot Circ_0020256 was especially identified based on having the highest differential expression level among all of the CircRNA candidates. In CCA cells (RBE and HCCC-9810), Circ_0020256 significantly promoted cellular activity by interacting with its intra-cellular microRNA target, miR-432-5p. In contrast, overexpression of transcription factor E2F3 in CCA cells restored the CCA cellular activities that were inhibited by miR-432-5p. On the other hand, treatment with small interference RNA (siRNA) for Circ_0020256 inhibited CCA cell proliferation, migration, and invasion both in vitro and in vivo. Yes In CCA cells (RBE and HCCC-9810), Circ_0020256 significantly promoted cellular activity by interacting with its intra-cellular microRNA target, miR-432-5p. In contrast, overexpression of transcription factor E2F3 in CCA cells restored the CCA cellular activities that were inhibited by miR-432-5p. On the other hand, treatment with small interference RNA (siRNA) for Circ_0020256 inhibited CCA cell proliferation, migration, and invasion both in vitro and in vivo. 35091535 MIR99AHG LncRNA Homo sapiens Pulmonary Fibrosis LUAD tissues and cell lines Interaction(miR-136-5p/USP4/ACE2 axis) Western Blot//Transfection//Co-IP//Migration Assay//FISH//qRT-PCR//Luciferase Report Assay//Invasion Assay//IF LncRNA MIR99AHG expression level was downregulated in LUAD tissues and cell lines. Functional analysis showed that MIR99AHG is associated with the LUAD malignant phenotype in vitro and in vivo. Further mechanistic studies showed that, MIR99AHG functions as a competitive endogenous RNA (ceRNA) to antagonize miR-136-5p-mediated ubiquitin specific protease 4 (USP4) degradation, thereby unregulated the expression of angiotensin-converting enzyme 2 (ACE2), a downstream target gene of USP4, which in turn affected alveolar type II epithelial cell fibrosis and epithelial-mesenchymal transition (EMT). MIR99AHG levels were associated with poorer patient overall survival. Yes Functional analysis showed that MIR99AHG is associated with the LUAD malignant phenotype in vitro and in vivo. 36138468 circCCAC1 CircRNA Homo sapiens Cholangiocarcinoma cancerous bile-resident EVs and tissues. Expression [highly expressed] qRT-PCR Circ-CCAC1 levels were increased in cancerous bile-resident EVs and tissues. For CCA cells, circ-CCAC1 increased cell progression by sponging miR-514a-5p to up-regulate Yin Yang 1 (YY1). Meanwhile, YY1 directly bound to the promoter of calcium modulating ligand to activate its transcription. The diagnostic and prognostic values of circ-CCAC1 were identified in patients with CCA. Yes For CCA cells, circ-CCAC1 increased cell progression by sponging miR-514a-5p to up-regulate Yin Yang 1 (YY1). In vivo studies further showed that increased circ-CCAC1 levels in circulating EVs and cells accelerated both CCA tumorigenesis and metastasis. 32750152 MIR99AHG LncRNA Homo sapiens Endometrial Neoplasms endometrial carcinoma (EC) and patients Interaction(MiR-636/GLCE axis) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//Invasion Assay//Transwell Assay In this study, we found MONC is low expression in endometrial carcinoma (EC) and patients in the MONC high-expression group had a better prognosis. MONC and miR-636 are relatively co-localized in the cytoplasm. MONC directly inhibits the malignant biological behavior of ECSCs and ECCs by directly inhibiting miR-636. Simultaneously, miR-636 may indirectly reduce the expression of MONC. Down-regulation of miR-636 may promote GLCE expression by targeting the 3'-untranslated region (UTR) of the downstream gene GLCE, thereby inhibiting the progression of ECSCs. Yes MONC and miR-636 are relatively co-localized in the cytoplasm. MONC directly inhibits the malignant biological behavior of ECSCs and ECCs by directly inhibiting miR-636. Simultaneously, miR-636 may indirectly reduce the expression of MONC. Down-regulation of miR-636 may promote GLCE expression by targeting the 3'-untranslated region (UTR) of the downstream gene GLCE, thereby inhibiting the progression of ECSCs. In addition, we verified the tumor suppressive effect of MONC in nude mice, miR-636 can rescue the tumor suppressive effect of overexpressing MONC. 34193130 MIR99AHG LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction(ANXA2 ) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//FISH//Cell Apoptosis Assay//IHC//Invasion Assay//IF All four of these transcripts were downregulated in LUAD tissues partly due to the copy number deletion of the MIR99AHG gene. Mechanistically, the interaction between MIR99AHG and ANXA2 could accelerate the ANXA2-induced ATG16L+ vesicle biogenesis, thus promoting phagophore assembly. Additionally, miR-99a targeted a well-known autophagy suppressor, mammalian target of rapamycin (mTOR), thereby synergistically promoting autophagy and postponing LUAD progression with MIR99AHG. Both MIR99AHG and miR-99a expression was positively correlated with the survival of LUAD patients. Yes MIR99AHG suppressed proliferation and metastasis and promoted autophagy both in vitro and in vivo. 33931593 NEAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues, CRC cells Interaction(NEAT1/miR-216b/YY1 axis) qRT-PCR//Western Blot The NEAT1 expression was significantly upregulated in CRC tissues compared with its expression in normal tissues, and downregulation of NEAT1 suppressed the proliferation, migration, and invasion of CRC cells. Moreover, we found NEAT1 decreased the miR-216b level directly, and the suppression of miR-216b could inhibit the function of downstream YY1. However, overexpression of YY1 accelerated CRC cell proliferation, migration, and invasion. Yes The NEAT1 expression was significantly upregulated in CRC tissues compared with its expression in normal tissues, and downregulation of NEAT1 suppressed the proliferation, migration, and invasion of CRC cells. 36262350 MSTRG.29039.1 LncRNA Homo sapiens Multiple Myeloma MM tissues Interaction(miR-12119 / JAK2/STAT3 pathway) Western Blot//Transfection//qPCR//Luciferase Report Assay//RNA-seq We verified that MSTRG.29039.1 and its target gene OSMR were highly expressed in MM. After knockdown of MSTRG.29039.1 in MM cell lines, the expression of OSMR was decreased, and the expression of hsa-miR-12119 was upregulated which can also promote cell apoptosis and inhibit proliferation. In a conclusion, lncRNA MSTRG.29039.1 could promote proliferation by sponging hsa-miR-12119 via the JAK2/STAT3 pathway in multiple myeloma. Yes After knockdown of MSTRG.29039.1 in MM cell lines, the expression of OSMR was decreased, and the expression of hsa-miR-12119 was upregulated which can also promote cell apoptosis and inhibit proliferation. 34422217 circHNRNPU CircRNA Homo sapiens Multiple Myeloma NPCs sample, MM cell Regulation(SKP2/ c-Myc ) Cell Cycle Assay//Transfection//Colony Formation Assay CircHNRNPU was one of the top most abundant and differentially expressed circRNA in IgD MM relative to lgG and NPCs samples. Due to circHNRNPU_603aa including RNA-binding RGG-box region, it regulated SKP2 exon skipping, thereby competitively inhibited c-Myc ubiquitin so as to stabilize c-Myc in MM. MM cells secreted circHNRNPU through exosomes to interfere with various cells in the BM microenvironment. Increased circHNRNPU was associated with poor outcomes in four independent MM patient cohorts. Yes Overexpressed circHNRNPU_603aa promoted MM cell proliferation in vitro and in vivo, in contrast knockdown of circHNRNPU_603aa by siRNA abrogated these effects. 35260179 Mirt2 LncRNA Rattus norvegicus Myocardial Infarction AMI rats Interaction(miR-764/PDK1 axis) In Vivo Experiment//Western Blot//Tunel//qRT-PCR//RIP//MTT//Luciferase Report Assay Additionally, the levels of Mirt2 in AMI rats were increased significantly. In summary, these findings suggest that that Mirt2 participated in the regulation of MI through the miR-764/PDK1 axis. Yes Knockdown of Mirt2 by shRNA (shMirt2) had no significant effect on apoptosis and MI in sham rats, but significantly promoted apoptosis and MI in AMI rats. In vitro experiments showed that shMirt2 significantly decreased the level of Mirt2 in H9c2 cells and H9c2 cells treated with H/R. It is worth noting that shMirt2 had no significant effect on H9c2 cells, but significantly increased the levels of oxidative stress markers (malondialdehyde and lactate dehydrogenase), and also increased the number of apoptosis of H/R-treated H9c2 cells. 33199822 NFIA-AS2 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[miR-655-3p/ZFX axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Based on informatic analyses by online database, lncRNA NFIA-AS2 in glioma tissues was overexpressed and further confirmed in glioma tissues and cells by quantitative real-time PCR (qRT-PCR). In conclusion, this study firstly reported that NFIA-AS2 could promote the progression of glioma by targeting the miR-665-3p/ZFX axis, which highlighted that NFIA-AS2 could be a novel biomarker and therapeutic target for glioma patients. Yes Functionally, silenced NFIA-AS2 could remarkably hinder glioma cell proliferation, migration and invasion, and cause the apoptosis. 32779154 NEAT1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues regulation[ALKBH5-NEAT1 axis] Flow Cytometry//qRT-PCR//RIP The results showed NEAT1 was remarkably enhanced in colon cancer tissues and correlated with poor prognosis. ALKBH5 knockdown suppressed malignant behavior of colon cancer partially through NEAT1 by demethylation in vitro and vivo, suggesting that ALKBH5-NEAT1 axis maybe potential therapeutic target for colon cancer treatment. The results showed NEAT1 was remarkably enhanced in colon cancer tissues and correlated with poor prognosis. Yes Knockdown of NEAT1 inhibited cell proliferation and migration, induced cell apoptosis in colon cancer cell lines. 32913527 NEAT1 LncRNA Homo sapiens Colonic Neoplasms colon cancer cells and tissues regulation[ NEAT1/miR-185-5p/IGF2 axis ] RNA Pull-Down//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay NEAT1 upregulate IGF2 expression through absorbing miR-185-5p to enhances the migration and invasion of colon cancer cells. Colon cancer patients with low NEAT1 expression presented with longer overall survival than those with high expression. Yes The migration and invasion of colon cancer cells were considerably promoted by overexpressed NEAT1. 32077635 NFYC-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LAUD cell lines Regulation(apoptosis of LAUD cells) Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay The proliferation, migration, and invasion of cells were inhibited and apoptosis was increased after NFYC-AS1 knockdown in LAUD cells. The cells transfected with NFYC-AS1 siRNA had a higher rate of apoptosis compared with that in control cells. The apoptosis-related proteins p53 and PARP were upregulated. These suggested NFYC-AS1 could inhibit the apoptosis of LAUD cells. In terms of the expression of major autophagy proteins, p62 was downregulated while Beclin 1 was upregulated after NFYC-AS1 knockdown, which suggested that autophagy was activated. The expression of oncogenic proteins MET and c-Myc was downregulated. Yes The proliferation, migration, and invasion of cells were inhibited and apoptosis was increased after NFYC-AS1 knockdown in LAUD cells. 34926665 MIR4435‑2HG LncRNA Homo sapiens Prostatic Neoplasms prostate cancer cell lines Interaction(ST8SIA1 ) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Colony Formation Assay//Transwell Assay The results revealed that MIR4435‑2HG expression was increased in the prostate cancer cell lines and MIR4435‑2HG expression was the highest in the PC‑3 cells. Interference with MIR4435‑2HG inhibited the proliferation, clone formation ability, and the invasion and migration of PC‑3 cells, as well as tumor growth by suppressing the activation of the FAK/AKT/β‑catenin signaling pathway. Yes Interference with MIR4435‑2HG inhibited the proliferation, clone formation ability, and the invasion and migration of PC‑3 cells, as well as tumor growth by suppressing the activation of the FAK/AKT/β‑catenin signaling pathway. 33846784 NEAT1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(miR-524-5p/ID1 axis) Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay In PTC tissues and cells, NEAT1 was significantly up-regulated. Bioinformatics prediction revealed the existence of binding sites between NEAT1 and miR-524-5p. Besides, ID1 was confirmed as a direct target to miR-524-5p, and the enhancement of ID1 reversed the regulation of miR-524-5p upregulation on cell progression. Yes NEAT1 silencing blocked cell proliferation, metastasis, and facilitated apoptosis in vitro and impeded xenograft tumor growth in vivo. 35635748 NEAT1 LncRNA Homo sapiens Carcinoma, Renal Cell RCC cells Epigenetics(methylation) Bioinformatics Analysis " The results showed that the expression level of LncRNA NEAT1 was upregulated after methylated by dCas13b-METTL3 in RCC cells. Finally, we examined the effect of LncRNA NEAT1 hypermethylation on the transcriptome. We found differentially expressed genes in RCC cells were associated with ""cGMP-PKG signaling pathway"", ""Cell adhesion molecules"" and ""Pathways in cancer"". " Yes And the proliferation and migration ability of RCC cells was decreased after methylated LncRNA NEAT1. 34957107 MIR99AHG LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[miR577/FOXP1 axis] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay MIR99AHG was strongly up-regulated in human GC and contributed to cancer progression. Moreover, MIR99AHG worked as an oncogenic gene though competing for endogenous RNA (ceRNA) of miR-577. Kaplan-Meier analysis revealed that up-regulating MIR99AHG expression was positively correlated with unfavorable overall survival (P < 0.01) of patients from our hospital and TCGA database. Yes Knockdown of MIR99AHG expression inhibited cell proliferation, invasion, migration and promoted cell apoptosis. 32874129 circVAPA CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-342-3p/ZEB2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay CircVAPA expression was upregulated in NSCLC tissues and cell lines, and a high level of circVAPA was associated with a poor prognosis of NSCLC patients. CircVAPA served as a molecular sponge for microRNA-342-3p (miR-342-3p). miR-342-3p interference largely reversed circVAPA knockdown-mediated anti-tumor effects in NSCLC cells. Zinc finger E-box-binding homeobox 2 (ZEB2) was a target of miR-342-3p, and miR-342-3p overexpression suppressed the malignant behaviors of NSCLC cells largely by downregulating ZEB2. CircVAPA expression was upregulated in NSCLC tissues and cell lines, and a high level of circVAPA was associated with a poor prognosis of NSCLC patients. Yes CircVAPA silencing suppressed the proliferation, migration, and invasion and induced the apoptosis of NSCLC cells. CircVAPA silence repressed xenograft tumor growth in vivo, and IHC assay confirmed that circVAPA silence restrained the proliferation and metastasis but induced the apoptosis of NSCLC cells in vivo. 34839824 circAGFG1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patients Interaction(miR-28-5p/HIF-1α axis) In Vivo Experiment//Western Blot//CCK8//Flow Cytometry//Transwell Assay circAGFG1 was highly expressed in NSCLC, and high expression of circAGFG1 was closely related to the low survival rate of NSCLC patients. circAGFG1 bound to miR-28-5p in NSCLC cells, and circAGFG1 promoted NSCLC progression partly through sponging miR-28-5p in vitro. HIF-1α was a target of miR-28-5p, and miR-28-5p overexpression-mediated influences in NSCLC cells were partly overturned by the addition of HIF-1α overexpression plasmid. circAGFG1/miR-28-5p/HIF-1α axis regulated cellular glycolytic metabolism in NSCLC cells. circAGFG1 was highly expressed in NSCLC, and high expression of circAGFG1 was closely related to the low survival rate of NSCLC patients. Yes circAGFG1 knockdown inhibited the proliferation, migration, and invasion and promoted the apoptosis of NSCLC cells. 34013042 NHEG1 LncRNA Homo sapiens Neuroblastoma NB tissues Interaction(hsa-miR-665/HMGB1 axis) Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay We observed that lncRNA NHEG1 was significantly upregulated in NB tissues as compared to the normal tissues. In NB tissues, lncRNA NHEG1 expression showed an inverse correlation with hsa-miR-665 (miR-655), but a positive correlation with high mobility group box 1 (HMGB1). In NB cell lines, lncRNA NHEG1 knockdown caused the upregulation of miR-665 and the downregulation of HMGB1. Yes Through a series of functional assays, we further demonstrated that lncRNA Nheg1 knockdown suppressed cell proliferation, migration and invasion of NB cells, which could be rescued by miR-665 inhibitor and HMGB1 overexpression. 34889712 NEAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Regulation[NEAT1/hsa-mir-139-5p/TGF-β1 axis] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP It was found that NEAT1 was significantly increased in human HCC cell lines including Hep3B, LM3, MHCC97L, SK-hep1, and HepG2 cells compared to the normal human liver cell line LO2. These data indicates that targeting the NEAT1/hsa-mir-139-5p/TGF-β1 axis could be a new strategy for HCC. Yes In addition, NEAT1 downregulation can restrain HCC cell growth, migration, and invasion. 29797561 MIR99AHG LncRNA Homo sapiens Pancreatic Neoplasms PCa cell lines Interaction(FOXA1/MIR99AHG/miR-3129-5p/ELAVL1/NOTCH2 axis) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//FISH//IF//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay MIR99AHG was distinctly overexpressed in PCa cell lines. Moreover, MIR99AHG up-regulation was induced by transcription factor forkhead box A1 (FOXA1). Furthermore, MIR99AHG modulated notch receptor 2 (NOTCH2) expression and stimulated Notch signaling pathway through sequestering microRNA-3129-5p (miR-3129-5p) and recruiting ELAV like RNA binding protein 1 (ELAVL1). Yes MIR99AHG deficiency abrogated PCa cell proliferation, migration and invasion. 34911544 NEF LncRNA Homo sapiens Triple Negative Breast Neoplasms blood Interaction[ regulating miRNA-155] CCK8//qRT-PCR//Transwell Assay Follow-up study showed that low level of lncRNA NEF and high level of miRNA-155 were correlated with poor survival. MiRNA-155 overexpression partially rescued the inhibited cell migration and invasion caused by lncRNA NEF overexpression. LncRNA NEF overexpression inhibited miRNA-155 expression, while miRNA-155 overexpression showed no significant effect on lncRNA NEF expression. Therefore, lncRNA NEF may participate in TNBC by negatively regulating miRNA-155. Yes LncRNA NEF overexpression inhibited the migration and invasion of TNBC cells, while miRNA-155 overexpression promoted the migration and invasion of TNBC cells, but showed no significant effects on cancer cell proliferation. 30839051 NEF LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Tumor tissues, paired adjacent normal tissues and serum Interaction[β-catenin] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot As shown in Fig. 1, Expression[down-expression]regulation of NEF in tumor tissue compared with in adjacent healthy tissue was identified in 50/62 patients (80.6%). Therefore, Expression[down-expression]regulation of NEF may be involved in the pathogenesis of LSCC.NEF overexpression inhibited proliferation and promoted apoptosis of LSCC cells, and also Expression[down-expression]regulated β-catenin expression. Tumor distant metastasis is a major cause of mortality in patients with LSCC. The data in Table I demonstrated that serum levels of NEF were not affected by the existence of distant metastasis. Therefore, follow-Expression[Expression[up-expression]-expression] data of all patients with LSCC were analyzed. Patients were divided into high (n=31) and low (n=31) groExpression[Expression[up-expression]-expression]s according to the median serum level of NEF. Survival curves of these two groExpression[Expression[up-expression]-expression]s were plotted using the Kaplan-Meier method and further compared using a log-rank test (Fig. 3). The overall survival rate of the low expression groExpression[Expression[up-expression]-expression] was significantly worse than that of the high expression groExpression[Expression[up-expression]-expression] (P=0.0249). Yes Therefore, the present study investigated the effects of NEF overexpression on β-catenin in the human LSCC cell line UM-SCC-17A. As shown in Fig. 4A, NEF overexpression significantly inhibited the expression of β-catenin (P<0.05). 31186702 NKILA LncRNA Homo sapiens cervical squamous cell carcinoma Serum regulation[downregulating miRNA-21] qRT-PCR In our studies, we found that serum NKILA was at lower levels and serum microRNA-21 (miRNA-21) was at higher levels in patients with early stage CSCC than in the healthy female. Yes Overexpression of NKILA repressed the proliferation and promoted the apoptosis of CSCC cells, while miRNA-21 showed opposite functions. 31950510 MRPS30-DT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and NSCLC cells Interaction(RPS9/JAK-STAT pathway ) RNA Pull-Down//CCK8//qRT-PCR//FISH//Flow Cytometry//Transwell Assay We identified a novel lncRNA (BRCAT54), which was significantly upregulated in preoperative plasma, NSCLC tissues and NSCLC cells, and its higher expression was associated with better prognosis in patients with NSCLC.Mechanistically, BRCAT54 directly bound to RPS9. Knockdown of RPS9 substantially reversed the promoting effects of si-BRCAT54 on cell proliferation and enhanced the inhibitive effect of si-BRCAT54 on BRCAT54 expression. In addition, silencing of RPS9 activated JAK-STAT pathway and suppressed calcium signaling pathway gene expressions. We identified a novel lncRNA (BRCAT54), which was significantly upregulated in preoperative plasma, NSCLC tissues and NSCLC cells, and its higher expression was associated with better prognosis in patients with NSCLC. Yes Overexpression of BRCAT54 inhibited proliferation, migration and activated apoptosis in NSCLC cells. Conversely, knockdown of BRCAT54 reversed the suppressive effects of BRCAT54. Moreover, overexpression of BRCAT54 repressed NSCLC cell growth in vivo. 32459848 NEAT1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues,cell lines Interaction[Silenced miR-133b] Western Blot//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay We also confirmed that lncRNA NEAT1 was up-regulated in breast cancer and inhibited the expression of miR-133b, and identified the mitochondrial protein translocase of inner mitochondrial membrane 17 homolog A (TIMM17A) that serves as the target of miR-133b. Yes Both miR-133b knockdown and TIMM17A overexpression in breast cancer cells promoted cell migration and invasion both in vitro and in vivo. 31344855 MR4435-2HG LncRNA Homo sapiens Breast Neoplasms breast cancer tissue Regulation(Wnt/β-catenin ) Western Blot//Migration Assay//CCK8//qRT-PCR//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay Using Gene Expression Profiling Interactive Analysis, an online web tool, it was revealed that MIR4435-2HG was upregulated in breast cancer tissue, and its high expression was associated with poor prognosis based on The Cancer Genome Atlas database. Furthermore, knockdown of MIR4435-2HG results in inactivation of the Wnt/β-catenin signaling pathway. Using Gene Expression Profiling Interactive Analysis, an online web tool, it was revealed that MIR4435-2HG was upregulated in breast cancer tissue, and its high expression was associated with poor prognosis based on The Cancer Genome Atlas database. Yes MIR4435-2HG knockdown increased cell apoptosis but decreased cell proliferation, migration and invasion. MIR4435-2HG knockdown increased pro-apoptotic protein expression but decreased anti-apoptotic protein expression. In addition, MIR4435-2HG knockdown leads to dysregulation of epithelial-to-mesenchymal transition-associated genes. 33777197 MRPS30-DT LncRNA Homo sapiens Neuroma, Acoustic VS samples Interaction(microRNA-21 ) RNA Pull-Down//Transfection//qRT-PCR//Luciferase Report Assay//BrdU We found that BRCAT54 was downregulated in VS samples than that in VN samples, while miR-21 was upregulated in VS samples.BRCAT54 and miR-21 were not closely correlated. BRCAT54 was detected in both nuclear and cytoplasm samples, and BRCAT54 directly interacted with miR-21. However, BRCAT54 and miR-21 did not affect the expression of each other. Yes BRCAT54 suppressed primary VS cell proliferation and inhibited the role of miR-21 in promoting cell proliferation. 35137654 hsa_circ_0069767 CircRNA Homo sapiens Multiple Myeloma MM tissues Expression[highly expressed] qRT-PCR//Western Blot//Transwell Assay The expression of circ_0069767 in MM was significantly higher than that of the normal control group. Yes Cell function experiments showed that overexpression of circ_0069767 in MM cells led to decreased proliferation, migration and invasion, but increased apoptosis; meanwhile, knockdown of circ_0069767 caused opposite biological behaviors. Circ_0069767 by sponging miR-636 in MM cells regulates the expression of K-RAS while the K-RAS gene remained unmutated. 33192092 hsa_circ_0000190 CircRNA Homo sapiens Multiple Myeloma bone marrow tissue Interaction[miR-767-5p/MAPK4 pathway] qRT-PCR//Luciferase Report Assay//Western Blot Circ_0000190 was located in the cytoplasm, and down-regulated in both bone marrow tissue and peripheral blood, while the target of circ_0000190, miR-767-5p, was up-regulated, suggesting a negative correlation between them. The binding ability between circ_0000190 and miR-767-5p was confirmed by luciferase reporter assay. Moreover, circ_0000190 inhibited cell viability, proliferation and induced apoptosis of MM thus inhibiting cell progression, which is partially through the negative regulation of miR-767-5p. Mitogen-activated protein kinase 4 (MAPK4) is a direct target of miR-767-5p. In addition, over-expression of miR-767-5p promoted cell progression by directly targeting and regulating MAPK4. Yes The MM model mice with administration of circ_0000190 suppressed tumor growth and progression. 30728056 hsa_circ_0008003 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-548I/KPNA4 ) In Vivo Experiment//CCK8//qRT-PCR//H&E Staining//IHC Circ_0008003 expression was increased in NSCLC tissues and cell lines. Moreover, miR-548I was targeted by circ_0008003, and miR-548I knockdown reversed the influence of circ_0008003 silence on NSCLC progression. KPNA4 was targeted by miR-548I, and miR-548I overexpression suppressed cell viability, migration, invasion, angiogenesis, and promoted cell apoptosis via decreasing KPNA4. In addition, circ_0008003 regulated KPNA4 expression via miR-548I. Circ_0008003 knockdown decreased NSCLC cell growth in the xenograft model. Yes Circ_0008003 knockdown reduced cell viability, migration, invasion, angiogenesis, and caused apoptosis in NSCLC cells. 36573325 MRPS30-DT LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC cells Interaction(miR-130b) BrdU//qRT-PCR//Transfection Overexpression of BRCAT54 and miR-130b was achieved in TNBC cells to explore the interaction between then. BRCAT54 was detected in cytoplasm and was predicted to be targeted by miR-130b. In TNBC cells, downregulation of BRCAT54 was observed after the overexpression of miR-130b. Yes Moreover, BRCAT54 decreased cell proliferation and miR-130b increased cell proliferation. Besides, BRCAT54 suppressed the role of miR-130b in increasing cell proliferation. 35191803 circSKA3 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues and cells Interaction(miR-520 h/CDK6) Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay "circSKA3 was remarkably up-modulated in medulloblastoma tissues. circSKA3 could decoyed miR-520 h, which targeted the 3' UTR of CDK6. circSKA3 expression in medulloblastoma tissues was negatively correlated with miR-520 h expression and positively correlated with CDK6 expression. ""Rescue"" experiments revealed that miR-520 h down-modulation or CDK6 overexpression remarkably counteracted the inhibitory effect of circSKA3 knockdown on Daoy cells. circSKA3 facilitates medulloblastoma progression through miR-520 h/CDK6." Yes CircSKA3 depletion markedly suppressed Daoy cell viability, migration, invasion, and cell cycle progression. CircSKA3 overexpression induced the opposite effects. 35352283 hsa_circ_0003176 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-182-5p/RBM5 Axis) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//Colony Formation Assay Our results indicated that hsa_circ_0003176 showed typical characteristic of circRNAs, which was downregulated in both NSCLC tissues and cell lines. Furthermore, we found that hsa_circ_0003176 acts as sponge of miR-182-5p to regulate RBM5 expression. Further, in vitro rescue experiments demonstrated that hsa_circ_0003176 suppressed the proliferation, migration, and invasion of NSCLC cells by regulating miR-182-5p/RBM5 axis. Yes NSCLC tissues and cell lines 36193508 NEAT1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Interaction[NEAT1/miR-1224/KLF3] qRT-PCR//MTT//Luciferase Report Assay Compared with adjacent normal tissues, lncRNA NEAT1 was significantly Expression[up-expression]-regulated, while miR-1224 was significantly down-regulated in lung cancer tissues. LncRNA NEAT1 could specifically bind to the 3'UTR of miR-1224 and regulate its expression. Yes The inhibition of lncRNA NEAT1 remarkably reduced the proliferation and enhanced the apoptosis of lung cancer cells. 31646570 MRPS30-DT LncRNA Homo sapiens Breast Neoplasms BC tissues Interaction[Targeting Jab1/Cops5] ISH//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay We found that MRPS30-DT was upregulated in breast cancer specimens and was accompanied by high Jab1 expression compared with that of paired para-carcinoma tissues.These data indicate the possible mechanisms of MRPS30-DT and Jab1 in breast cancer; thus, MRPS30-DT and Jab1 may be novel prognostic biomarkers and potential therapeutic targets for breast cancer treatment. Yes Knocking down MRPS30-DT significantly inhibited cancer cell proliferation and invasion and induced apoptosis in breast cancer cells.Similarly, knocking down MRPS30-DT in MDA-MB-231 cells significantly suppressed tumor growth. 31788446 MNX1‑AS1 LncRNA Mus musculus Prostatic Neoplasms prostate cancer tissues and cell lines. Regulation(miR‑2113/MDM2 axis) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Bioinformatics Analysis//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay The expression of MNX1‑AS1 was significantly upregulated in the prostate cancer tissues and cell lines. MNX1‑AS1 knockdown suppressed the abilities of cell viability and migration and invasion in vitro and inhibited tumor growth in vivo. Additionally, luciferase reporter assay revealed that MNX1‑AS1 could target miR‑2113 and negatively interacted with miR‑2113 in prostate cancer cells. miR‑2113 directly targeted to MDM2 and negatively modulated the expression of MDM2. Rescue assays suggested that the viability, migration and invasion of impaired cells triggered by transfection with sh‑MNX1‑AS1 alone could be recovered by co‑transfection with sh‑MNX1‑AS1 + miR‑2113 inhibitor or sh‑MNX1‑AS1 + pCDH‑ MDM2 vector. The present study demonstrated that MNX1‑AS1 promoted prostate cancer progression through regulating miR‑2113/ MDM2 axis. Yes MNX1‑AS1 knockdown suppressed the abilities of cell viability and migration and invasion in vitro and inhibited tumor growth in vivo. 35616155 MNX1-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Expression[highly expressed] CCK8//qRT-PCR//Transwell Assay Expression of MNX1-AS1 was significantly higher in GC vs. adjacent non-tumor tissues. Higher MNX1-AS1 expression was significantly associated with tumor size, TNM stage and lymph node metastasis. Kaplan-Meier analysis showed that GC patients with higher MNX1-AS1 expression had worse OS compared to patients with lower MNX1-AS1 expression. Multivariate analysis showed that MNX1-AS1 is an independent poor prognostic factor in GC. Yes Knockdown of MNX1-AS1 significantly inhibited proliferation, migration and invasion of AGS and MGC-803 cells, and resulted in increased E-cadherin and decreased PCNA, N-cadherin, vimentin and MMP-9 expression. 30821221 NEAT1 LncRNA Homo sapiens Stomach Neoplasms GC specimens and cell lines Interaction(miR-17-5p/TGFβR2 Axis ) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//ELISA//IHC//IF We observed that NEAT1 was upregulated in most GC specimens and cell lines. Mechanism researches revealed that NEAT1 could competitively sponge miR-17-5p which targeted TGFβR2 directly. Subsequently, activate TGFβ/Smad pathway by following with upregulation of a series of classical proangiogenic factors especially VEGF. NEAT1 high was correlated with poor prognosis of GC patients. Yes In vitro experiments showed that NEAT1 promoted GC angiogenesis by enhancing proliferation, migration, and tube formation ability of endothelial cells. 34552925 MNX1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissue Interaction[repressing CDKN1A] qRT-PCR//Western Blot//Transwell Assay MNX1-AS1 expression in GC samples was significantly higher than that of the corresponding normal tissues. Our results suggested that MNX1-AS1 could enhance the metastasis and invasion of GC cells via suppressing CDKN1A. Meanwhile, MNX1-AS1 expression was associated with the overall survival time of GC patient. Yes Moreover, the migration and invasion of GC cells were markedly promoted after MNX1-AS1 overexpression in vitro. 31210302 MNX1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissue samples and cell lines regulation[EZH2/BTG2 and miR-6785-5p/BCL2 axes] Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Transwell Assay//ChIP It was found that MNX1-AS1 displayed obvious upregulation in GC tissue samples and cell lines, and ectopic expression of MNX1-AS1 predicted poor clinical outcomes for patients with GC.Our findings demonstrate that MNX1-AS1 may be able to serve as a prognostic indicator in GC patients and that TEAD4-activatd MNX1-AS1 can promote GC progression through EZH2/BTG2 and miR-6785-5p/BCL2 axes, implicating it as a novel and potent target for the treatment of GC. It was found that MNX1-AS1 displayed obvious upregulation in GC tissue samples and cell lines, and ectopic expression of MNX1-AS1 predicted poor clinical outcomes for patients with GC. Yes Overexpressed MNX1-AS1 expression promoted proliferation, migration and invasion of GC cells markedly, whereas decreased MNX1-AS1 expression elicited the opposite effects. 31924214 MIR4435‑2HG LncRNA Homo sapiens Liver Neoplasms primary liver cancer and liver cancer cell lines Interaction(miR‑136‑5p axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay The results revealed that MIR4435‑2HG expression was upregulated in primary liver cancer and liver cancer cell lines, and was positively associated with advanced tumor stage, metastasis and poor prognosis in patients with liver cancer. Furthermore, miR‑136‑5p was determined to be a direct target of MIR4435‑2HG and suppressed MIR4435‑2HG expression by binding with the seed region of the 3'‑UTR of MIR4435‑2HG in liver cancer cells. Furthermore, the target gene, B3GNT5, of miR‑136‑5p was confirmed by bioinformatics analysis and RT‑qPCR. In addition, B3GNT5 expression was regulated by the MIR4435‑2HG/miR‑136‑5p axis. The results revealed that MIR4435‑2HG expression was upregulated in primary liver cancer and liver cancer cell lines, and was positively associated with advanced tumor stage, metastasis and poor prognosis in patients with liver cancer. Yes Knockdown of MIR4435‑2HG significantly inhibited the proliferation, migration and invasion of liver cancer cells. 34859256 MNX1-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[AKT/mTOR pathway] qRT-PCR//Western Blot//Transwell Assay Our results show that MNX1-AS1 expression was significantly higher in breast cancer tissues than adjacent normal tissues. Our results suggest that MNX1-AS1 is a functional oncogene that induces epithelial-mesenchymal transition, in addition to activating AKT/mTOR pathway and its natural sense transcript MNX1 in breast cancer cells. Yes Moreover, knockdown/overexpression of MNX1-AS1 inhibits/promotes proliferation, migration and invasion of breast cancer cells. 30697072 MRAK050699 LncRNA Rattus norvegicus Silicosis silicosis rats Regulation( TGF-β/Smad3 signaling) In Vivo Experiment//Western Blot//qRT-PCR//RNA-seq//IHC//Bioinformatics Analysis//IF There were 1077 differentially expressed lncRNAs (378 upregulated and 699 downregulated). MRAK052509, MRAK139674, AY539881, MRAK050699, XR_6113, and BC167061 were selected to verify expression in silicosis rats using quantitative reverse transcription polymerase chain reaction. MRAK050699 was knocked down in rat alveolar type II epithelial cells, and the molecular mechanism of transforming growth factor-β (TGF-β)-induced EMT in these cells was studied. All selected lncRNAs were upregulated in the silicosis rats, consistent with the sequencing results. MRAK050699 knockdown inhibited EMT of RLE-6TN cells by regulating the TGF-β/Smad3 signaling pathway. Thus, the differential expression of lncRNAs is related to silicosis development, and MRAK050699 plays an important role in EMT, suggesting a potential therapeutic target for silicosis Yes MRAK050699 knockdown inhibited EMT of RLE-6TN cells by regulating the TGF-β/Smad3 signaling pathway. Thus, the differential expression of lncRNAs is related to silicosis development, and MRAK050699 plays an important role in EMT, suggesting a potential therapeutic target for silicosis 34779285 hsa_circ_0007841 CircRNA Homo sapiens Multiple Myeloma cell lines regulation[miR-338-3p/BRD4 signaling ] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0007841 was highly expressed in bone marrow (BM)-derived plasma cells of MM patients and MM cell lines than that in healthy volunteers and normal plasma cell line nPCs. Circ_0007841 acted as an oncogene to promote the proliferation, cell cycle and motility and restrain the apoptosis of MM cells through sequestering miR-338-3p to up-regulate the expression of BRD4. Yes Circ_0007841 promoted the proliferation, cell cycle and metastasis and impeded the apoptosis of MM cells. 32782441 NEF LncRNA Homo sapiens stomach carcinoma blood Interaction[targeting RUNX1] CCK8//qRT-PCR//Western Blot It was revealed that NEF was significantly downregulated in tumor tissues compared with in adjacent tissues. In addition, NEF overexpression promoted, and NEF siRNA silencing inhibited, Runx1 expression. Levels of circulation NEF in serum were lower in patients with gastric carcinoma compared with in healthy controls, and were decreased with the increasing stages of primary tumor. Yes NEF siRNA silencing promoted, and overexpression inhibited, gastric carcinoma proliferation. 30664208 NEAT1 LncRNA Homo sapiens Breast Neoplasms cell lines Interaction[ microRNA‑107] qRT-PCR NEAT1 expression was increased in BC cells, whereas miR‑107 expression was decreased, compared with normal mammary gland cells.Furthermore, NEAT1 promoted the expression of CPT1A, which was mediated by miR‑107. The results of the present study indicate that NEAT1 promotes the expression of CPT1A by inhibiting miR‑107 to improve the progression of BC cells; therefore, NEAT1 is a potential therapeutic target of BC. Yes NEAT1 promoted the progression of BC cells through inhibiting apoptosis‑associated genes and promoting cell cycle‑ and invasion‑associated gene expression, whereas miR‑107 served the opposite function. 31485672 NEAT1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells regulation[miR-138-5p/ ZFX Axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay NEAT1 was highly expressed and miR-138-5p was lowly expressed in BC tissues and cells. NEAT1 affected BC progression through modulating miR-138-5p/ZFX axis, providing a vital theoretical basis for BC treatment. Yes NEAT1 interference or miR-138-5p restoration repressed cell proliferation, migration, and invasion but accelerated apoptosis in BC cells. 32833504 MRPL23-AS1 LncRNA Homo sapiens Carcinoma, Adenoid Cystic patient tissues and cell lines Interaction(MRPL23-AS1/p19INK4D axis ) Western Blot//Flow Cytometry//qRT-PCR//IHC//ChIP MRPL23-AS1 recruited the EZH2 to the promoter region of p19INK4D, inhibited p19INK4D expression, and promoted tumor cell anoikis resistance. The novel MRPL23-AS1/p19INK4D axis may be a potential SACC biomarker or therapeutic target. Yes The functional experiments showed that MPRL23-AS1 could promote anoikis resistance in vitro. 35175670 NEAT1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[NEAT1/miR‑124/STAT3] Western Blot//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay The results demonstrated that NEAT1 and STAT3 expression levels were increased in breast cancer tissues compared with normal breast tissues, whereas miR‑124 expression was significantly decreased.Additionally, NEAT1 and STAT3 expression levels were negatively correlated with miR‑124 levels in breast cancer tissues. A direct interaction between miR‑124, and NEAT1 and STAT3, was predicted by bioinformatics analysis and confirmed using a luciferase activity assay. NEAT1 overexpression markedly increased STAT3 protein expression levels, and this effect was reversed by miR‑124 overexpression in breast cancer cells. Furthermore, miR‑124 overexpression partially attenuated the effects of NEAT1 on breast cancer cell proliferation and cell cycle progression. The inhibitory effects of miR‑124 overexpression on the proliferation rate and cell cycle progression were abolished by STAT3 overexpression. In turn, STAT3 silencing inhibited NEAT1 transcription in breast cancer cells. In summary, the present findings revealed that NEAT1 and STAT3 formed a feedback loop via sponging miR‑124 to promote breast cancer progression. Yes Functional analyses revealed that NEAT1 promoted cell proliferation and cell cycle progression in breast cancer cells. 31322202 NEAT1 LncRNA Homo sapiens Breast Neoplasms human breast cancer cells Interaction(miR-448 and ZEB1) qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis We observed that NEAT1 levels were significantly increased in human breast cancer cells including MCF-7, MDA-MB-453, MDA-MB-231, and SKBR3 cells compared to normal mammary epithelial cells MCF-10A while miR-448 was decreased. To conclude, we uncovered that NEAT1 participated in breast cancer progression by regulating miR-448 and ZEB1. Yes We found that downregulation of NEAT1 was able to inhibit the growth of breast cancer cells and miR-448 mimic exerted the similar function. 29323713 hsa_circ_0017620 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells and tissues Interaction(miR-520a-5p/KRT5 axis) In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay//Transwell Assay Hsa_circ_0017620 was upregulated in NSCLC cells and tissues. MiR-520a-5p had been verified to be a target miRNA of hsa_circ_0017620 and KRT5 had been verified to be a target mRNA of miR-520a-5p in NSCLC cells. In this study, we found that hsa_circ_0017620 played an important role in NSCLC progression. Hsa_circ_0017620 regulated cell proliferation, invasion, and migration through targeting miR-520a-5p/KRT5 axis in NSCLC, providing a potential new target for the treatment and diagnosis of NSCLC. Yes Knockdown of hsa_circ_0017620 inhibited cell proliferation, migration, and invasion in NSCLC cells, which was reversed by downregulating miR-520a-5p or upregulating KRT5 in NSCLC. Overexpression of hsa_circ_0017620 had opposite effects in NSCLC. hsa_circ_0017620 silencing inhibited tumor growth in vivo of NSCLC. 35302673 MRPL23-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(microRNA miR-30b/MYH9) qRT-PCR//Luciferase Report Assay//RNA Pull-Down In the present study, we showed that lncRNA MRPL23-AS1 was remarkably increased in OS tissues and cell lines. In terms of mechanism, luciferase reporter, RNA pull-down and fluorescence in situ hybridization (FISH) assays showed that MRPL23-AS1 competitively interacted with miR-30b, increasing myosin heavy chain 9 (MYH9) expression, a trans- activator of β-catenin, resulting in the activation of Wnt/β-catenin pathway, thereby promoting OS tumorigenesis and metastasis. Yes Stable knockdown of MRPL23-AS1 evidently attenuated cell viability and invasive ability, meanwhile inhibited in vivo tumor growth and dissemination. 33356805 MRPL39 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell interaction[miR-130] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that MRPL39 was significantly downregulated in GC tissues and cell lines and that its expression level was negatively associated with carcinoma size, tumor, lymph node, metastasis (TNM) stage, and lymphatic metastasis. Taken together, these findings indicate that MRPL39 serves as a tumor suppressor by directly targeting miR-130 in GC, which suggests that it might be a novel biomarker in the diagnosis and prognosis of GC. We found that MRPL39 was significantly downregulated in GC tissues and cell lines and that its expression level was negatively associated with carcinoma size, tumor, lymph node, metastasis (TNM) stage, and lymphatic metastasis. Patients with low MRPL39 expression levels revealed a short overall and disease-free survival period. Yes Over-expression of MRPL39 in the GC cell lines BGC823 and SGC-7901 inhibited cell growth, proliferation, migration, and invasion. 30452299 NEAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Regulation[miR-101-3p/SOX9/Wnt/β-Catenin Signal Pathway] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expressions of NEAT1 were significantly higher in both of NSCLC tissues and cells than in normal controls. Moreover, NEAT1 also takes part in NSCLC progression via miR-101-3p/SOX9/Wnt/β-catenin axis. High expression of NEAT1 was significantly associated with TNM stage (P=0.000) and metastasis (P=0.000). Yes NEAT1 knockdown inhibited the proliferation, migration and invasion of NSCLC cells. 30845377 MROCKI LncRNA Homo sapiens Leukemia, Myeloid, Acute blood samples and cultured AML cells regulation[down-regulating miR-204-5p] CCK8//qRT-PCR//Western Blot//Transwell Assay Here, we report that LOC285758 expression is higher in clinical AML blood samples and cultured AML cells. Our findings suggest that targeting of miR-204-5p by LOC285758 promotes the cell viability and invasion of AML cells, and thus LOC285758 may have potential as a therapeutic target for AML treatment. Yes LOC285758 overexpression promoted AML cell viability and invasion abilities, which were effectively inhibited by miR-204-5p overexpression; moreover, miR-204-5p overexpression also regulated the expression of E-cadherin, N-cadherin and Twist1. The data also showed that increased LOC285758 expression could effectively suppress the earlier effects of miR-204-5p on AML cells. 32067385 hsa_circ_0000518 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cells Interaction(miR-330-3p/SLC1A5 axis) CCK8//qRT-PCR//In Vivo Experiment//FISH circ_0000518 expression was enhanced in NSCLC. circ_0000518 functioned as a molecular sponge for miR-330-3p, and inhibition of miR-330-3p in cells markedly reversed circ_0000518 interference-mediated antitumor effects. miR-330-3p interacted with 3'-UTR of SLC1A5. miR-330-3p inhibitor-mediated protumor effect was remarkably reversed in cells after the knockdown of SLC1A5. Yes si-circ_0000518 inhibited cell proliferation, invasion, and glutamine metabolism. 35874898 NEAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines regulation[NEAT1/ miR-204/ NUAK1 Axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay The results revealed that NEAT1 was obviously enhanced in LC cell lines.In summary, our results showed that the down-regulation of NEAT1 in NSCLC inhibited its growth, migration and invasion through the miR-204/NUAK1 axis. Yes Further functional analysis showed that low expression of NEAT1 obviously suppressed the growth, migration and invasion of NSCLC and facilitated cell apoptosis. 33402847 NEAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[ has-miR-376b-3p/SULF1 axis ] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay In this study, the expression of NEAT1 and SULF1 was upregulated in NSCLC tissues and cells.In this study, we found that lncRNA NEAT1 regulated cell proliferation, invasion, migration, and apoptosis by targeting has-miR-376b-3p/SULF1 axis in NSCLC. Yes Of note, the knockdown of NEAT1 and SULF1 could inhibit cell proliferation, migration, and invasion and promote cell apoptosis in NSCLC. 32432744 MROCKI LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines and tissues Regulation(MAP3K7) qRT-PCR In this study, we identified that LINC01268 was highly expressed in HCC cell lines and tissues. High LINC01268 expression level was associated with lower HCC nodule number, moderate/poor differentiation and poor overall survival. Knockdown of LINC01268 inhibited the proliferation of HCC cells, which was enhanced by overexpression of LINC01268. Co-expression analysis implied an interaction between LINC01268 and MAP3K7. Similar to LINC01268, MAP3K7 was highly expressed in HCC cells, and positively correlated with moderate/poor differentiation as well as poor prognosis. Knockdown of LINC01268 in HCC cell lines led to reduction of MAP3K7 at both mRNA and protein levels. Phenotypic effects due to LINC01268 overexpression in HCC cells were reversed by knockdown of MAP3K7. High LINC01268 expression level was associated with lower HCC nodule number, moderate/poor differentiation and poor overall survival. Yes Knockdown of LINC01268 in HCC cell lines led to reduction of MAP3K7 at both mRNA and protein levels. Phenotypic effects due to LINC01268 overexpression in HCC cells were reversed by knockdown of MAP3K7. 33727826 NEAT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues interaction[NEAT1/miR-590-3p/MDM2 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay We found that NEAT1 was overexpressed in ESCC tissues and correlated with clinical characteristics of patients.These findings suggested that NEAT1/miR-590-3p/MDM2 axis might serve as potential therapeutic targets for ESCC patients. We found that NEAT1 was overexpressed in ESCC tissues and correlated with clinical characteristics of patients. Yes Silence of NEAT1 inhibited proliferation, migration, invasion and angiogenesis of ESCC cells. 33680941 hsa_circ_0009043 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells and tissue samples Interaction(miR-148a-3p/DNAJB4 axis) In Vivo Experiment//Flow Cytometry//RIP//Cell Proliferation Assay//IHC Both NSCLC cells and tissue samples were found to exhibit circ_0009043 upregulation, and lower circ_0009043 expression levels were found to be related to poorer NSCLC patient overall survival. Mechanistically, circ_0009043 was found to function as a molecular sponge that sequestered miR-148a-3p, which was in turn able to directly suppress DNAJB4 expression. Both NSCLC cells and tissue samples were found to exhibit circ_0009043 upregulation, and lower circ_0009043 expression levels were found to be related to poorer NSCLC patient overall survival. Yes Knocking down circ_0009043 resulted in the enhancement of NSCLC cell proliferative activity and the suppression of apoptotic tumor cell death in vitro, while also driving more rapid in vivo tumorigenesis. 35974419 MROCKI LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow samples regulation[miR-217/SOS1 axis] CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay LINC01268 was significantly upregulated by 1.6 fold in bone marrow samples of AML patients, which was associated with poor prognosis.LINC01268 promoted cell growth and inhibited cell apoptosis through modulating miR-217/SOS1 axis in AML. Yes LINC01268 knockdown inhibited viability and cell cycle progression but promoted apoptosis of AML cells. 32609259 NEAT1 LncRNA Homo sapiens Stomach Neoplasms tumor tissues and cells Interaction(microRNA-142-5p/JAG1 axis) In Vivo Experiment//Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay The results indicated that NEAT1 was highly expressed in tumor tissues and cells compared with that in paracancerous tissues and the normal gastric epithelial cell line GES-1 and significantly associated with poor prognosis in gastric cancer.Mechanistically, NEAT1 sponged miR-142-5p to regulate JAG1 expression. In addition, the effects of NEAT1 knockdown on the proliferation, migration and invasion of gastric cancer cells could be rescued by miR-142-5p inhibitor, and JAG1 overexpression reversed the miR-142-5p-mediated effects on gastric cancer cells. The results indicated that NEAT1 was highly expressed in tumor tissues and cells compared with that in paracancerous tissues and the normal gastric epithelial cell line GES-1 and significantly associated with poor prognosis in gastric cancer. Yes Functional analyses further demonstrated that NEAT1 knockdown suppressed proliferation, motility and tumor growth in vitro and in vivo. 34178135 NEAT1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[ NEAT1/miR-365a-3p/ABCC4 ] Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay We found NEAT1 increased expression in both GC tissues and cells and correlated with poorer overall survival of cancer patients. In this study, we revealed a NEAT1/miR-365a-3p/ABCC4 triplet in GC progression, which may provide novel targeted therapy markers for GC. We found NEAT1 increased expression in both GC tissues and cells and correlated with poorer overall survival of cancer patients. Yes We found NEAT1 overexpression promotes, while its knockdown inhibits GC cell proliferation, colony formation, invasion, and cell cycle progression in vitro. 32494153 NEAT1 LncRNA Homo sapiens Stomach Neoplasms GC cells and tissues regulation[miR-103a/ STAMBPL1 Axis] CCK8//qRT-PCR//Western Blot//Transwell Assay Our study indicated that LncRNA NEAT1 was up-regulated in GC cells and tissues. NEAT1 was targeted and inhibited by miR-103a and acted as an oncogene, which promoted the malignant behavior of GC cells. This regulatory effect of NEAT1 may be associated with STAMBPL1. Yes Moreover, NEAT1 knockdown and miR-103a overexpression inhibited cell proliferation and cell invasion. 33111649 NEAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[NEAT1/DDX5/Wnt/β-catenin axis] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay NEAT1 expression was significantly upregulated in CRC tissues compared with its expression in normal tissues. The NEAT1/DDX5/Wnt/β-catenin axis could be a potential therapeutic target of pharmacological strategies. Yes Altered NEAT1 expression led to marked changes in proliferation, migration, and invasion of CRC cells both in vitro and in vivo. 30185232 MSC-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell interaction[miR-524-5p,NR4A2 ] Tunel//CCK8//qRT-PCR//EdU Staining//Transwell Assay MSC-AS1 was upregulated in NPC tissues and cells. Mechanistically, MSC-AS1 sequestered miR-524-5p to upregulate NR4A2 expression in NPC cells. Yes Functional assays indicated that MSC-AS1 exacerbated cell proliferation, hindered apoptosis, and facilitated invasion and epithelial-to-mesenchymal transition (EMT) in NPC. 32368184 MNX1-AS1 LncRNA Homo sapiens colorectal adenocarcinoma COAD patients and cells Interaction(LncRNA MNX1-AS1/PPFIA4/AKT/HIF-1α ) qRT-PCR COAD patients with high expression of the lncRNA MNX1-AS1 have poor prognosis. LncRNA MNX1-AS1/PPFIA4 activates the downstream AKT/HIF-1α signaling pathway to promote COAD development. LY29004 significantly inhibits the tumorigenic ability of lncRNA MNX1-AS1 and PPFIA4. COAD patients with high expression of the lncRNA MNX1-AS1 have poor prognosis. Yes LncRNA MNX1-AS1 promotes the stemness of COAD cells. PPFIA4 mediates lncRNA MNX1-AS1 expression and affects COAD cell stemness. LncRNA MNX1-AS1 accelerates proliferation and migration, while it suppresses apoptosis. LncRNA MNX1-AS1/PPFIA4 accelerates tumor growth in COAD model. 36226248 MSC-AS1 LncRNA Homo sapiens Glioma TMZ-resistant glioma tissues and cells Interaction(miR-373-3p/CPEB4 axis & PI3K/Akt pathway) Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay MSC-AS1 was up-regulated in TMZ-resistant glioma tissues and cells, and glioma patients with high MSC-AS1 expression tend to have lower overall survival rate. MSC-AS1 suppression reduced the IC50 value of TMZ and proliferation, promoted apoptosis and TMZ sensitivity, and affected PI3K/Akt pathway in TMZ-resistant glioma cells. MSC-AS1 acted as miR-373-3p sponge, and miR-373-3p directly targeted CPEB4. Silencing miR-373-3p reversed the promoting effect of MSC-AS1 or CPEB4 knockdown on TMZ sensitivity. Furthermore, MSC-AS1 knockdown inhibited TMZ-resistant glioma growth in vivo by regulating miR-373-3p/CPEB4 axis through PI3K/Akt pathway. Collectively, MSC-AS1 knockdown suppressed cell growth and the chemoresistance of glioma cells to TMZ by regulating miR-373-3p/CPEB4 axis in vitro and in vivo through activating PI3K/Akt pathway. Yes MSC-AS1 knockdown inhibited TMZ-resistant glioma growth in vivo by regulating miR-373-3p/CPEB4 axis through PI3K/Akt pathway. Collectively, MSC-AS1 knockdown suppressed cell growth and the chemoresistance of glioma cells to TMZ by regulating miR-373-3p/CPEB4 axis in vitro and in vivo through activating PI3K/Akt pathway. 33106913 MSC-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and HCC cells regulation[PGK1] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay MSC-AS1 was obviously upregulated in HCC tissues and HCC cells. Taken these together, we indicated that MSC-AS1 promoted HCC oncogenesis via inducing the expression of PGK1. Yes Knockdown of MSC-AS1 repressed HepG2 and BEL-7404 cell proliferation, colony formation capacity, and triggered cell apoptosis. 32489020 MSC-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//Flow Cytometry//Colony Formation Assay//Transwell Assay The expression of MSC-AS1 in HCC cell lines was significantly higher than that in L02. Yes In the MSC-AS1 siRNA group, the proliferation and colony formation of HCC cells were inhibited, whereas the apoptosis rate was significantly higher than that in the blank and NC-siRNA groups. The rate of wound healing and the number of invasion cells in the MSC-AS1 siRNA group were significantly lower than that in the blank and NC-siRNA groups. 33625998 MNX1-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues,cell lines Interaction[inhibiting KISS1] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay MNX1-AS1 was higher-expressed in osteosarcoma samples than that in adjacent tissues.The abilities of proliferation and invasion were suppressed after MNX1-AS1 was knocked down in vitro. Yes The abilities of proliferation and invasion were suppressed after MNX1-AS1 was knocked down in vitro. 31364121 MSC-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-325/TRIM14 Axis) Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay We found that MSC-AS1 and TRIM14 were upregulated in CRC tissues, while miR-325 was downregulated in CRC tissues. Additionally, miR-325 was proved to be a target miRNA of MSC-AS1, and TRIM14 might be a downstream gene of miR-325. Besides that, MSC-AS1 counteracted the inhibitory effect of miR-325 on the cell progression and TRIM14 expression. Yes Functional experiments demonstrated that MSC-AS1 knockdown inhibited cell proliferation, migration, and invasion abilities in CRC cells. 34054957 circSEC61A1 CircRNA Homo sapiens Multiple Myeloma MM tissues and cells Interaction(miR-660-5p/CDK6 axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ_SEC61A1 level was increased in MM tissues and cells. CDK6 was identified as the target of miR-660-5p, and circ_SEC61A1 sponged miR-660-5p to positively regulate CDK6 expression. Yes Circ_SEC61A1 was a stable circRNA and mainly located in cytoplasm. Circ_SEC61A1 silence restrained the proliferation, metastasis and expedited the apoptosis in MM cells. 35030455 hsa_circ_0001821 CircRNA Homo sapiens Multiple Myeloma bone marrow tissues and cell lines Expression(highly expressed) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT Circ_0001821 expression was increased in bone marrow tissues and cell lines from multiple myeloma compared with that in normal controls, and its expression was related to hemoglobin, bone injury, β2-MG, and globulin. In multiple myeloma patients aged ≥60 years, high circ_0001821 expression displayed lower overall survival (OS) rate compared with low circ_0001821 expression.High circ_0001821 expression was an independent prognostic indicator for the poor OS. Yes Overexpression of circ_0001821 led to increased proliferation and arrested apoptosis of multiple myeloma cells, while knockdown of circ_0001821 had the opposite effects. 34555307 MSC-AS1 LncRNA Homo sapiens clear cell renal cell carcinoma regulation[miR-3924/WNT5A/β-catenin axis] qRT-PCR In this study, MSC-AS1 was dramatically upregulated in KIRC and correlated with dismal prognosis of KIRC patients.This study revealed that MSC-AS1 regulates KIRC cell proliferation and migration via miR-3924/WNT5A/β-catenin axis. Yes Knockdown of MSC-AS1 would suppress the proliferative and migratory properties of KIRC cells. 31916281 MSC-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression [highly expressed] CCK8//qRT-PCR//Western Blot In this study, we demonstrated that the expression of MSC-AS1 in GC tissues was significantly higher than that in non-tumor tissues. Moreover, the elevated level of MSC-AS1 was detected in GC cells (MKN-45, AGS, SGC-7901, and MGC-803) compared to normal GES-1 gastric mucosal cells. Mechanistically, modulating MSC-AS1 level affected the expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), but did not impact the levels of hexokinase 2 (HK2) and pyruvate kinase M2 (PKM2) in GC cells. The cancer genome atlas (TCGA) data further indicated that the high level of MSC-AS1 was closely correlated with advanced tumor stage and poor prognosis of GC. Yes Next, we revealed that MSC-AS1 knockdown inhibited the proliferation, glucose consumption, lactate production, and pyruvate production of MGC-803 cells. Conversely, MSC-AS1 overexpression enhanced the proliferation and glycolysis of AGC cells. 33390824 NEAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tumor and matched non-tumor tissues Regulation[Wnt/β-catenin signaling pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Consistent with the data from GEO database, NEAT1 levels were significantly higher in CRC tissues than in adjacent normal tissues (p < 0.001).Moreover, NEAT1 functions as an oncogene influencing cell viability and invasion in part by serving as a competing endogenous RNA (ceRNAs) modulating miRNA-34a expression, leading to subsequent repression of the miR-34a/SIRT1 axis and activation of the Wnt/β-catenin signaling pathway. In this study, we report that NEAT1 expression is up-regulated in colorectal cancer tissues, which correlates with advanced clinical features, poor overall survival and disease free survival. Yes Up-regulated NEAT1 promotes cell proliferation and metastasis of colorectal cancer both in vitro and in vivo. 30312725 MNX1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Interaction[MAPK pathway] qRT-PCR In the beginning, we found that the expression of MNX1-AS1 was obviously upregulated in cervical cancer tissues and cell lines. Taken together, it was identified that MNX1-AS1 promoted proliferation and inhibited apoptosis of cervical cancer cells through MAPK pathway. Yes Moreover, by loss-of-function and gain-of-function assay, the effect of MNX1-AS1 on cell proliferation and apoptosis was examined on cellular level. 30302806 MNX1-AS1 LncRNA Homo sapiens Glioblastoma GBM tissues and cell lines Interaction[inhibiting miR-4443] CCK8//qRT-PCR//Luciferase Report Assay Here we found that the expression of MNX1-AS1 was significantly upregulated in GBM tissues and cell lines. In terms of mechanism, we found that MNX1-AS1 could bind to miR-4443 in GBM cells. Overexpression of miR-4443 significantly inhibited the expression of MNX1-AS1 and vice versa. Moreover, there was an inverse correlation between the expression levels of MNX1-AS1 and miR-4443 in GBM tissues. We found that overexpression of miR-4443 inhibited the proliferation, migration, and invasion of GBM cells. We also showed that inhibition of miR-4443 reversed the effects of MNX1-AS1 knockdown on GBM cell proliferation, migration, and invasion. Taken together, we found that MNX1-AS1 promoted the proliferation, migration, and invasion of GBM cells through inhibiting miR-4443. Yes Knockdown of MNX1-AS1 significantly inhibited the proliferation, migration, and invasion of GBM cells. 29678219 MNX1-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues Expression[highly expressed] qRT-PCR In our study, we observed levels of MNX1-AS1 expression through analyzing The Cancer Genome Atlas and found MNX1-AS1 expression was highly expressed in lung adenocarcinoma tissues compared with normal lung tissues, but there was no statistical difference between lung squamous cell carcinoma tissues and normal lung tissues. Furthermore, we conducted quantitative real-time polymerase chain reaction, and confirmed that the expression of MNX1-AS1 was definitely higher in lung adenocarcinoma tissue samples, but not in lung squamous cell carcinoma tissue samples. In addition, high MNX1-AS1 expression was found to be associated with the low differentiated degree, advanced clinical stage, big tumor size, lymph node metastasis, and distant metastasis in lung adenocarcinoma patients. High expression of MNX1-AS1 was negatively correlated with overall survival time and served as an independent unfavorable prognostic factor in patients with lung adenocarcinoma. Yes The in vitro functional studies suggested that suppression of MNX1-AS1 inhibited lung adenocarcinoma cell proliferation and migration, and promoted apoptosis. 30506837 NEF LncRNA Homo sapiens cervical squamous cell carcinoma blood Interaction[TGF-β pathway] qRT-PCR//Western Blot//Transwell Assay We found that expression of NEF in cervical tissues (tumor tissues for CSCC patients) and serum was significantly down-regulated in HPV-negative CSCC patients than in healthy controls and HPV positive patients, but no significant differences were found between healthy controls and HPV positive patients.Therefore, we conclude that lncRNA NEF may inhibit the migration and invasion of HPV-negative cervical squamous cell carcinoma by inhibiting TGF-β pathway. Low serum levels of NEF distinguished HPV-negative CSCC patients from healthy controls and indicated poor survival. Yes NEF overexpression inhibited the migration and invasion of HPV-negative but not HPV-positive CSCC cells. 30910843 NEF LncRNA Homo sapiens Cholangiocarcinoma IHCC tissues,blood Interaction[RUNX1] qRT-PCR//Western Blot//Transwell Assay In the present study we found that lncRNA-NEF was down-regulated, while Runt-related transcription factor 1 (RUNX1) was up-regulated in tumor tissues than in adjacent healthy tissues of IHCC patients. LncRNA-NEF overexpression led to inhibited expression of RUNX1 in cells of IHCC cell lines and inhibited cancer cell migration and invasion. In contrast, RUNX1 overexpression showed no significant effects on lncRNA-NEF expression, but attenuated the effects of lncRNA-NEF overexpression on cancer cell migration and invasion. We therefore concluded that lncRNA-NEF participated in IHCC possibly by interacting with RUNX1. Patients were followed up for 5 years, patients with high plasma levels of lncRNA-NEF showed significantly better survival conditions compared with patients with low expression levels of lncRNA-NEF. Yes LncRNA-NEF overexpression led to inhibited expression of RUNX1 in cells of IHCC cell lines and inhibited cancer cell migration and invasion. 31015363 NEF LncRNA Homo sapiens Small Cell Lung Carcinoma SCLC tissues Interaction[TGF-β1] qRT-PCR//Western Blot//Transwell Assay The results demonstrated that the expression level of lncRNA-NEF was lower in patients with SCLC compared with that in healthy controls. lncRNA-NEF overexpression inhibited SCLC cell migration and invasion, resulting in TGF-β1 downregulation, while treatment with exogenous TGF-β1 reduced the inhibitory effects of lncRNA-NEF overexpression on migration and invasion. Yes lncRNA-NEF overexpression inhibited SCLC cell migration and invasion, resulting in TGF-β1 downregulation, while treatment with exogenous TGF-β1 reduced the inhibitory effects of lncRNA-NEF overexpression on migration and invasion. 31186707 MSC-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction(MSC-AS1/miRNA-429 Axis/JAK1/STAT3 ) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of MSC-AS1 presented significant upregulation, and miR-429 expression was markedly downregulated in NPC tissues and cells. The level of MSC-AS1 had negative relation to the miR-429 level. miR-429 was an antitumor gene inhibiting NPC growth and metastasis through JAK1/STAT3 pathway. In C666-1 cells, the elevated cell growth and migration induced by the miR-429 inhibitor were significantly reversed by si-JAK1 transfection. Yes Knockdown of MSC-AS1 suppressed the proliferation, invasion, and migration of C666-1 cells. On the contrary, overexpressing of MSC-AS1 exerts the opposite effects on C666-1 cell growth and migration. miR-429 was determined as functional downstream of MSC-AS1. The suppressive function of MSC-AS1 knockdown was predominately abolished by the miR-429 inhibitor. 36213586 NEAT1_2 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Interaction(miR-491 /TGM2/NFκb/FN1 Axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//IF//Luciferase Report Assay//IHC//Bioinformatics Analysis//Transwell Assay In PTC tissues, NEAT1_2 expression was markedly increased and regulated TGM2 expression. NEAT1_2 sponged miR-491, acting as a competing endogenous RNA to regulate TGM2 expression. Fibronectin 1 (FN1) was predicted as a TGM2 target. TGM2 could transcriptionally activate FN1 by promoting nuclear factor kappa B (NFκb) p65 nuclear translocation, ultimately promoting PTC invasion/metastasis. TGM2 was overexpressed in PTC, correlating positively with exthyroidal extension and lymph node metastasis. Yes TGM2 knockdown significantly inhibited invasion and metastasis. 33738254 MNX1-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC tumor tissues and cells Interaction(miR-744-5p/SOX12 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//H&E Staining The expression of MNX1-AS1 was increased in OC tumor tissues and cells. Elevated MNX1-AS1 expression is associated with advanced stage and lower overall survival rate. Yes Knockdown of MNX1-AS1 inhibited cell proliferation, migration and invasion, blocked cell cycle, and promoted cell apoptosis in SKOV-3 and OVCAR-3 cells. MNX1-AS1 was competitively binding with miR-744-5p, and its downstream target gene was SOX12. 34789303 NEAT1_1 LncRNA Homo sapiens Arthritis, Rheumatoid Fibroblast-like synoviocytes Interaction(miR-221-3p/uPAR axis) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//FISH//migration assay//cell invasion assay//Cell Cycle Assay//ELISA The targeting of NEAT1_1 and miR-221-3p/uPAR axis may have a promising therapeutic role in patients with RA. Yes In line with the biologic function, NEAT1_1 negatively regulates the tumor-like characters, and cytokine secretions of RA-FLSs. 34254354 NEAT1 LncRNA Homo sapiens Stomach Neoplasms Gastric Cancer tissues regulation[H3K27me3 and H3K4me3 ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//FISH//Luciferase Report Assay//IHC//ChIP Here, we demonstrated that the expression of NEAT1 was significantly increased and negatively correlated with prognosis in GC. Mechanistically, NEAT1 bound BRG1 (SMARCA4) directly, modulating H3K27me3 and H3K4me3 in the GADD45A promoter to regulate GADD45A-dependent G2/M cell cycle progression. Yes Further experiments revealed that NEAT1 silencing significantly suppressed cell proliferation both in vitro and in vivo and induced apoptosis. 33230443 NEAT1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues regulation[miR-1224-5p/RSF1 Signaling Axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay Our findings revealed high expression levels of NEAT1, RSF1 and a decreased expression level of miR-1224-5p in gastric cancer.Our research initially validated that NEAT1 may regulate the expression of RSF1 competitive sponge to miR-1224-5p, contributed to the supervision of gastric cancer evolution, which exposed new brightness for diagnosis and therapy of gastric cancer. Yes Upregulation of NEAT1 or knockdown of miR-1224-5p elevated gastric cancer cell proliferation, and migration. 33244266 MNX1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung tissue,cell lines Expression[highly expressed] qRT-PCR Compared with normal lung tissue, the expression of MNX1-AS1 was significantly increased in lung cancer tissues (p<0.05). The expression level of MNX1-AS1 in NSCLC cell line A549 was significantly higher than that in human normal lung epithelial cell line Beas-2B (p<0.05). MNX1-AS1 expression was significantly associated with TNM stage and lymph node metastasis (p<0.05). Kaplan-Meier survival curve analysis showed that high expression of MNX1-AS1 was associated with a poor prognosis in NSCLC. Yes In addition, knockdown of MNX1-AS1 inhibited proliferation, migration and invasion of the NSCLC cell line A549 and promoted apoptosis. 31118668 MSC-AS1 LncRNA Homo sapiens Diabetic Nephropathies DN patients and HRMC cells Interaction(miR-325/CCNG1 Axis) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//ELISA Upregulation of lncRNA MSC-AS1 was detected in DN patients and HRMC cells treated with high glucose (HG). In addition, lncRNA MSC-AS1 acts as a miR-325 sponge in the DN. CCNG1 is the direct target of miR-325, which can be positively regulated by lncRNA MSC-AS1 in DN. More importantly, downregulation of miR-325 and upregulation of CCNG1 can attenuate the protective effect of lncRNA MSC-AS1 knockdown on DN. Yes Knockdown of lncRNA MSC-AS1 reduced the proliferation, fibrosis, and inflammation of HRMC cells induced by HG. 35126911 MNX1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Regulation[miR-34a/SIRT1 axis] qRT-PCR MNX1-AS1 was signifcantly upregulated in ESCC tissues.Mechanism analysis revealed that miR-34a inhibitor could rescue the influence of inhibiting MNX1-AS1 on ESCC cells migration by serving as competing endogenous RNA (ceRNAs). Furthermore, we found that miR-34a specifically targeted SIRTI. It was conformed that high MNX1-AS1 expression was associated with ESCC lymph node metastasis. Yes Moreover, we found that knockdown of MNX1-AS1 apparently suppressed the cell proliferation, migration, and invasion capacity. 31170665 MNX1-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Interaction[ miR-527/BRF2 pathway] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In our research, we found that MNX1-AS1 was dramatically upregulated in lung cancer. Mechanistically, MNX1-AS1 was found to locate in the cytoplasm and interact with miR-527. Through inhibiting miR-527 availability, MNX1-AS1 facilitated BRF2 expression. Restoration of BRF2 rescued defects of proliferation, migration, and invasion caused by MNX1-AS1 knockdown. Taken together, our study found a novel signaling pathway, namely MNX1-AS1/miR-527/BRF2 axis, involved in lung cancer progression. Yes Functionally, MNX1-AS1 promoted lung cancer progression through regulating proliferation, migration, and invasion. 30618167 MNX1-AS1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cells Interaction( c-Myc/MNX1-AS1/IGF2BP1 positive feedback loop) CCK8//Luciferase Report Assay//Flow Cytometry High levels of MNX1-AS1 were associated with poor clinical outcomes in patients with lung cancer. MNX1-AS1 bound and drove phase separation of IGF2BP1, which increased the interaction of IGF2BP1 with the 3'-UTR (untranslated region) of c-Myc and E2F1 mRNA to promote their stability. The c-Myc/MNX1-AS1/IGF2BP1 positive feedback loop accelerated cell-cycle progression and promoted continuous proliferation of lung cancer cells. High levels of MNX1-AS1 were associated with poor clinical outcomes in patients with lung cancer. Yes MNX1-AS1 promoted cell proliferation and colony formation in vitro and tumor growth in vivo. In a lung cancer patient-derived xenograft model, inhibition of MNX1-AS1 suppressed cancer cell proliferation and tumor growth. 36214649 MNX1-AS1 LncRNA Homo sapiens Lung Neoplasms Cancer stem cells (CSCs) Interaction(MNX1-AS1/POU2F2/MYO1G axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//Transwell Assay Gene Expression Omnibus dataset, MNX1-AS1was found to be highly expressed in lung cancer tissues and cells. Deletion of MNX1-AS1 inhibited proliferation, migration, invasion and sphere-forming abilities of CSC. Furthermore, subcellular fractionation, fluorescence in situ hybridization, RNA immunoprecipitation, and dual-luciferase experiments demonstrated that MNX1-AS1 recruited the transcription factor POU domain class 2 transcription factor 2 (POU2F2) to the nucleus and activated the myosin IG (MYO1G) expression. MYO1G overexpression partially reversed the si-MNX1-AS1-decreased stemness of CSCs. Finally, MNX1-AS1 suppression significantly repressed the growth of xenografts in vivo. Our study highlights the importance of the MNX1-AS1/POU2F2/MYO1G axis in stem cell-like properties of lung cancer cells. Yes MYO1G overexpression partially reversed the si-MNX1-AS1-decreased stemness of CSCs. Finally, MNX1-AS1 suppression significantly repressed the growth of xenografts in vivo. 35819746 NEAT1 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues and cancer cell lines regulation[ cGAS/STING pathway] Flow Cytometry//qRT-PCR//RIP//MTT//Colony Formation Assay//Transwell Assay The results showed that NEAT1 was overexpressed in lung cancer tissues and cancer cell lines.Our findings demonstrated that NEAT1 interacted with DNMT1 to regulate cytotoxic T cell infiltration in lung cancer via inhibition of cGAS/STING pathway. Yes In vitro studies displayed that inhibition of NEAT1 with shRNA resulted in suppression of survival and migration/invasion of lung cancer cells. 32296457 MNX1-AS1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Regulation(YB1) qRT-PCR//RNA Pull-Down MNX1-AS1 expression was significantly upregulated in colorectal cancer and associated with poor prognosis. MNX1-AS1 bound to and activated Y-box-binding protein 1 (YB1), a multifunctional RNA/DNA-binding protein,and prevented its ubiquitination and degradation. Yes In vitro and in vivo gain- and loss-of-function experiments showed that MNX1-AS1 promotes the proliferation of colorectal cancer cells. A marked overlap between genes that are differentially expressed in MNX1-AS1 knockdown cells and transcriptional targets of YB1 was observed. 33782099 NEAT1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[miR-1294/AKT1 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay NEAT1 and AKT1 were distinctly up-regulated and miR-1294 was down-regulated in GC tissues and cells.NEAT1 could modulate cell proliferation, apoptosis, and metastasis in GC cells by regulating the PI3K/AKT/mTOR signaling pathway via the miR-1294/AKT1 axis, showing the great potential for NEAT1 as a valid biomarker in the progression and treatment of GC. Yes Cell proliferation and metastasis were refrained but apoptosis was promoted in GC cells after knockdown of NEAT1. 33336058 MNX1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation[ miR-218-5p/COMMD8 axis] CCK8//qRT-PCR//Transwell Assay In this study, we found that MNX1-AS1 was remarkably Expression[up-expression]regulated in HCC tissues and cell lines.Mechanistically, we identified that MNX1-AS1 was a competing endogenous RNA (ceRNA) for miR-218-5p. We demonstrated that MNX1-AS1 promoted COMMD8 expression through sponging miR-218-5p, and then contributed to HCC progression. Restoration of COMMD8 significantly reversed the effects of MNX1-AS1 knockdown. Furthermore, MNX1-AS1 overexpression was related to advanced stage and metastasis, and predicted poor prognosis. Yes Loss-of-function assays showed that MNX1-AS1 knockdown sExpression[up-expression]pressed the proliferation, migration and invasion of HCC cells in vitro.Further investigation indicated that MNX1-AS1 silencing delayed HCC growth in vivo. 30982576 NEAT1 LncRNA Homo sapiens Stomach Neoplasms cell lines Interaction[sponging miR-506] qRT-PCR Here, we observed that NEAT1 and STAT3 expressions were significantly upregulated in human GC cells including BGC823, SGC-7901, AGS, MGC803, and MKN28 cells compared with normal gastric epithelial cells GES-1, while miR-506 was downregulated. Therefore, it was hypothesized in our study that NEAT1 can be recognized as a competing endogenous RNA to modulate STAT3 by sponging miR-506 in GC. Yes We inhibited NEAT1 and observed that NEAT1 inhibition was able to repress the growth, migration, and invasion of GC cells. 29363783 circMYBL2 CircRNA Homo sapiens Multiple Myeloma MM tissue and serum samples Interaction(Cyclin F) In Vivo Experiment//Western Blot//Co-IP//qRT-PCR//RIP In the present study, we identified a MM-associated circular RNA (circRNA), circ-MYBL2, which was dramatically decreased in MM tissue and serum samples in comparison to normal samples. Low circ-MYBL2 level was closely correlated with high clinical stage and unfavorable outcome, and serum circ-MYBL2 had excellent accuracy in diagnosing MM. Yes Exogenous circ-MYBL2 expression notably repressed MM cell viability, DNA synthesis and cell cycle progression. Importantly, overexpression of circ-MYBL2 significantly reduced the tumor size of subcutaneous xenografts in nude mice. 33058028 NEAT1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[ALKBH5] qRT-PCR//Transwell Assay NEAT1 was overexpressed in GC cells and tissue. ALKBH5 affected the m6A level of NEAT1. The binding of ALKBH5 and NEAT1 influences the expression of EZH2 (a subunit of the polycomb repressive complex) and thus affects GC invasion and metastasis. Our findings indicate a novel mechanism by which ALKBH5 promotes GC invasion and metastasis by demethylating the lncRNA NEAT1. They may be potential therapeutic targets for GC. Yes Additional experiments confirmed that knockdown of NEAT1 significantly repressed invasion and metastasis of GC cells. 31290116 NEAT1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Regulation[miR-497-5p/PIK3R1 axis] RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay NEAT1 was upregulated in GC tissues, promoted proliferation, and inhibited apoptosis of GC cells.NEAT1 could directly bind to and negatively regulate miR-497-5p expression. PIK3R1 was then identified as a downstream target of miR-497-5P. In GC cell models, PIK3R1 was found to be directly negatively regulated by miR-497-5p and indirectly positively regulated by NEAT1. Yes Finally, NEAT1 knockdown inhibited tumor growth, increased miR-497-5p expression, and decreased PIK3R1 expression in xenograft model mice compared with the negative control. 31486491 MSC-AS1 LncRNA Homo sapiens Melanoma melanoma cell lines Interaction(miR-302a-3p/IGF2BP2/LEF1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay It was observed that MSC-AS1 and lymphoid enhancer-binding factor 1 (LEF1) were remarkably up-regulated while microRNA-302a-3p (miR-302a-3p) down-regulated in melanoma cell lines.Furthermore, MSC-AS1 regulated LEF1 expression through sponging miR-302a-3p and recruiting insulin like growth factor 2 mRNA-binding protein 2 (IGF2BP2). Eventually, LEF1 overexpression rescued cell progression impaired by MSC-AS1 knock-down. Yes . The silencing of MSC-AS1 hindered cell proliferation, migration and epithelial-mesenchymal transition (EMT) in vitro and tumor growth in vivo. 34218464 MIR4435-2HG LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction(miR-22-3p/TMEM9B ) RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//IF//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay MIR4435-2HG was notably up-regulated in breast cancer tissues and cell lines. MiR-22-3p expression was down-regulated in breast cancer tissues and cell lines, and negatively associated with MIR4435-2HG expression. Over-expression of miR-22-3p obviously inhibited the viability, proliferation, migration, invasion and EMT of breast cancer cell lines. Furthermore, TMEM9B was up-regulated in breast cancer tissues and cell lines and negatively associated with miR-22-3p expression. TMEM9B inhibition partially restored the effects of MIR4435-2HG/miR-22-3p on the viability, proliferation, migration, invasion and EMT of breast cancer cell lines. Yes Additionally, down-regulation of MIR4435-2HG restrained the viability, proliferation, migration, invasion and EMT of breast cancer cells. 36105009 NKILA LncRNA Homo sapiens Diabetic Cardiomyopathies blood Expression[highly expressed] qRT-PCR A 8-year-follow-up study on 312 diabetic patients without exhibiting obvious complications demonstrated that plasma lncRNA NKILA levels were upregulated specifically in diabetic patients who developed DC but not in patients with other complications. Yes Although in vitro experiments demonstrated that lncRNA NKILA expression in cardiomyocyte cells was not affected by high-glucose treatment, ectopic lncRNA NKILA expression and lncRNA NKILA knockdown potentiated, and inhibited cardiomyocyte apoptosis, respectively. 31316617 MIR210HG LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer cells Interaction(miR-125b-5p/HK2/PKM2 axis) CCK8//Transfection//qPCR//Luciferase Report Assay In this study, lncRNA MIR210HG was abnormally upregulated within pancreatic cancer. It acted as a key oncogenic regulator of pancreatic cancer aggressiveness and glycolysis. In conclusion, MIR210HG affected the phenotypes of pancreatic cancer cells, including proliferation, invasion, migration, and glycolysis, via modulating the miR-125b-5p/HK2/PKM2 axis. Yes Knockdown of MIR210HG significantly inhibited the aggressive phenotype of pancreatic cancer cells and inhibited the growth of xenograft tumours. 34110962 MIR23AHG LncRNA Homo sapiens Nasopharyngeal carcinoma Nasopharyngeal carcinoma tissues Regulation[Rho/Rac signaling pathway] ISH//Wound Healing Assay//Western Blot Therefore, we performed gene expression profiling to screen for altered expression of lncRNAs in NPC tissues and adjacent samples. One lncRNA, LOC284454, was upregulated and associated with poor prognosis in NPC. Mass spectrometry combined with bioinformatics suggested that LOC284454 affected the cytoskeletal and adhesion-related Rho/Rac signaling pathways. LOC284454 may be a potential novel treatment target and is expected to be a new diagnostic and prognostic marker in patients with NPC. Yes In in vivo and in vitro assays, LOC284454 promoted the migration and invasion capacity of NPC cells. 30380023 MIR31HG LncRNA Homo sapiens Adenocarcinoma of Lung LUAD specimens and some LUAD cell lines Interaction(lncRNA MIR31HG/miR-193a-3p/TNFRSF21 regulatory axis) Western Blot//Transfection//Wound Healing Assay//RIP//qRT-PCR//Cell Proliferation Assay//Transwell Assay MIR31HG was highly expressed in LUAD specimens and some LUAD cell lines. MIR31HG showed oncogenic features via sponging miR-193a-3p and tended to positively regulate TNFRSF21 expression. In a word, lncRNA MIR31HG acts as an oncogene in LUAD by targeting miR-193a-3p to modulate TNFRSF21, which may be beneficial to the gene therapy of LUAD. Yes Inhibition of MIR31HG clearly reduced the proliferation, migration, and invasion of the LUAD cells. 35936736 MIR31HG LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Regulation[Wnt/β-catenin signaling pathway] CCK8//qRT-PCR//Western Blot The present study demonstrated that MIR31HG was significantly increased in tumor tissues compared with adjacent normal tissues, and increased MIR31HG expression levels were associated with histological differentiation grade, lymph node metastasis and Tumor-node metastasis (TNM) stage in patients with NSCLC. Furthermore, the results of the present study demonstrated that downregulated MIR31HG inhibited the Wnt/β-catenin signaling pathway by decreasing the expression of glycogen synthase kinase 3β (GSK3β) and β-catenin, but increasing the phosphorylated (p)-GSK3β expression in NSCLC cells. The present study demonstrated that MIR31HG was significantly increased in tumor tissues compared with adjacent normal tissues, and increased MIR31HG expression levels were associated with histological differentiation grade, lymph node metastasis and Tumor-node metastasis (TNM) stage in patients with NSCLC. Patients who had a higher MIR31HG expression level, were predicted a shorter over survival (OS) time. Yes Using in vitro assays, the present study demonstrated that the downregulation of MIR31HG expression significantly inhibited cell proliferation and cell invasion abilities. 30655759 MIR31HG LncRNA Homo sapiens Uterine Cervical Neoplasms cervical carcinoma tissues interaction[sponge for miR-361-3p] Western Blot//EdU Staining//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Colony Formation Assay//Invasion Assay MIR31HG was strikingly upregulated in clinical cervical carcinoma specimens compared with that in adjacent samples.Mechanistically, MIR31HG was identified as an endogenous 'sponge' through competing for miR-361-3p binding to modulate the miRNA target, epithelial membrane protein 1 (EMP1). Yes Functionally, knockdown of MIR31HG noticeably repressed cervical carcinoma cell growth and invasiveness in vitro and inhibited cervical carcinoma cell growth in vivo. 32819595 NNT-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and cell lines Interaction( miR-30c/NPM1) qRT-PCR//RNA Pull-Down//RIP NNT-AS1 and NPM1 expressions in EC tissues and cell lines were higher than in benign endometrium and normal endometrial epithelial cells (EECs). miR-30c expression in EC tissues and cell lines was lower than in benign endometrium and normal EECs. NNT-AS1 interacted with miR-30c, and miR-30c negatively regulated NPM1 expression. Overexpression of NNT-AS1 increased NPM1 expression in EC cells, while overexpression of miR-30c reversed the effect. Yes Estradiol (E2) promoted the proliferation of EC cells, small interfering RNA (siRNA) against NNT-AS1 inhibited EC cell proliferation, miR-30c inhibitor promoted cell proliferation, and NPM1 siRNA inhibited cell proliferation. E2 increased tumor volume, and NNT-AS1 interference reduced tumor volume in vivo. 34976175 circPRMT5 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines regulation[miR-30c/E2F3 Axis] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay ?CircPRMT5 expression was upregulated in PTC tissues and cell lines. Our findings demonstrate that circPRMT5 acts as an oncogenic circRNA to promote PTC progression via regulating miR-30c/E2F3 axis. And circPRMT5 level was positively linked with advanced stage and lymph node metastasis. Yes ?CircPRMT5 knockdown inhibited proliferation, migration and invasion while inducing apoptosis. 32494192 MIR29B2CHG LncRNA Homo sapiens Breast Neoplasms Cell Lines and Tissues Interaction(miR-29 ) Flow Cytometry//qRT-PCR//Wound Healing Assay We observed that C1orf132 long transcript is significantly downregulated in triple-negative breast cancer.Knocking-out the promoter by means of CRISPR/Cas9 revealed no alterations in the expression of the neighboring genes CD46 and CD34, while the expression of miR-29c was reduced by half. Altogether, we are reporting here the existence of an additional/distal promoter with an enhancer effect on miR-29 generation and an inhibitory effect on cell migration. Yes Furthermore, the promoter knockout elevated the migration ability of the edited cells. 34201896 NEAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissue and cell lines interaction[microRNA-365] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay The present study demonstrated that expression of NEAT1 was significantly higher in OSCC tissue and cell lines compared with adjacent non-tumour tissue and normal oral keratinocytes, respectively. Additionally, upregulation of NEAT1 was significantly associated with advanced clinical stage and shorter survival time in patients with OSCC. Yes Furthermore, inhibition of NEAT1 expression led to a significant reduction in OSCC cell migration and invasion, which was accompanied by reduced matrix metalloproteinase (MMP)-2 and MMP9 protein expression. 30186464 hsa_circ_102002 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells regulation[miR-488-3p/HAS2 axis] Western Blot//ISH//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//IHC//Transwell Assay Our results suggested the upregulation of circ_102002 in PTC tissues and cells, and its promoting effects on epithelial-mesenchymal transition (EMT) and cell migration.These findings about the signal axis of circ_102002/miR-488-3p/HAS2 may further elucidate the PTC pathogenesis and improve clinical treatment. Yes Moreover, the inhibitory effect of downregulation of circ_102002 on PTC growth was evaluated in a mouse xenograft model, which involved miR-488-3p and HAS2 regulation. 32862195 circNCOR2 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells regulation[circ-NCOR2/miR-615a-5p/MTA2 axis] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Circ-NCOR2 overexpression was observed in PTC tissues and cells. Taken together, our findings reveal a novel circ-NCOR2/miR-615a-5p/MTA2 axis in PTC, which could become a potential therapeutic target for this disease. Yes Silenced or overexpressed expression of circ-NCOR2 strikingly attenuated or facilitated, respectively, the growth, migration, and invasion of PTC cells. 32940102 NEAT1 LncRNA Homo sapiens Hemangioma HA tissues Interaction[miR-361-5p/VEGFA pathway] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We found that compared with normal skin tissues, NEAT1 expression was elevated, whereas miR-361-5p decreased in HA tissues especially in proliferating phase HAs.NEAT1 functioned as a competing endogenous RNA to regulate VEGFA expression via sponging miR-361-5p. Taken together, these findings indicate that NEAT1 promotes the proliferation and migration, whereas inhibits the apoptosis of HemECs via regulating miR-361-5p/VEGFA axis. Yes Downregulation of NEAT1 significantly suppressed the viability, PCNA expression and migration, but increased apoptotic cell numbers and caspase-3 activity of HemECs. 30928097 NEAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cell line regulation[VEGF-A and Notch signaling pathway] qRT-PCR Expressions of lncRNA NEAT1 and VEGF-A were both increased significantly in OSCC cell lines especially in TSCC1 cell line. LncRNA NEAT1 may upregulate proliferation and EMT and repress apoptosis through activating VEGF-A and Notch signaling pathway in vitro, suggesting an underlying regulatory factor in OSCC. Yes Suppression of lncNRA NEAT1 was associated with lower cell viabilities and EMT and higher apoptosis rate in the TSCC1 cell line. 33023572 circFAT1(e2) CircRNA Homo sapiens Thyroid Cancer, Papillary PTC cell lines and tissues regulation[miRNA-873/ZEB1 Axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, circFAT1(e2) was found to be highly expressed in PTC cell lines and tissues. In conclusion, the results of this study indicated that circFAT1(e2) played a carcinogenic role by targeting the miR-873/ZEB1 axis to promote PTC invasion and metastasis, which might become a potential novel target for therapy of PTC. Yes circFAT1(e2) knockdown suppressed PTC cell growth, migration, and invasion. 33133224 MIR22HG LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cell lines Regulation[NOTCH2 signaling] CCK8//qRT-PCR//Western Blot//Transwell Assay MIR22HG expression was decreased in gastric cancer tissues and cells (P<0.05).MIR22HG negatively regulated NOTCH2 signaling. Silencing MIR22HG elevated HEY1 and nucleus NOTCH2 expression. Silencing of NOTCH2 suppressed AGS and MKN-45 cells proliferation, migration and invasion (all P<0.05). CONCLUSIONS LncRNA MIR22HG suppressed gastric cancer progression through attenuating NOTCH2 signaling. Low MIR22HG expression indicated lower 5-year overall survival rate (P<0.05). Yes Upregulation of MIR22HG inhibited AGS and MKN-45 cell proliferation, migration and invasion (all P<0.05). Downregulation of MIR22HG elevated AGS and MKN-45 cell proliferation, migration, and invasion (all P<0.05). 30670679 NNT-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms cell lines Regulation[miR-1301-3p/PODXL axis] qRT-PCR Here, we found that NNT-AS1 was upregulated in BC cells.These data suggested that NNT-AS1 enhances BC cell growth and activates Wnt pathway by targeting miR-1301-3p/PODXL axis. Yes Functionally, the silencing of NNT-AS1 inhibited cell proliferation, migration, invasion, and endothelial-mesenchymal transition. Furthermore, the apoptosis of BC cells was induced upon NNT-AS1 knockdown. 31782983 MIR22HG LncRNA Homo sapiens Carcinoma, Hepatocellular liver tissues Interaction[miR-10a-5p/NCOR2 axis] Northern Blot//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay We report that MIR22HG was downregulated in 120 HCC samples compared with adjacent nontumor liver tissues.In exploring the molecular mechanism of MIR22HG, we found that MIR22HG functioned as a tumor suppressor in hepatocellular carcinomas, in part through serving as a competing endogenous RNA to modulate the miRNA-10a-5p level. Moreover, NCOR2 was verified to act as the downstream target gene of MIR22HG/miR-10a-5p. In addition, the MIR22HG/miRNA-10a-5p/NCOR2 axis inhibited the activation of the Wnt/β-catenin pathway. Together, our results demonstrated that MIR22HG inhibited HCC progression in part through the miR-10a-5p/NCOR2 signaling axis and might act as a new prognostic biomarker for HCC patients. Yes Knockdown of MIR22HG promoted the growth, migration and invasion of HCC cells. 30680848 MIR22HG LncRNA Homo sapiens Osteosarcoma Osteosarcoma Cells and osteosarcoma tissues Interaction(miR-629-5p/TET3 Axis) qRT-PCR//Luciferase Report Assay//Western Blot MiR-629-5p could competitively bind with and was negatively correlated with MIR22HG, the latter of which was evidenced by the high expression of miR-629-5p and low expression of MIR22HG in osteosarcoma tissues. TET3 was the target gene of miR-629-5p, and the promotive effects of upregulated miR-629-5p on the viability and proliferation as well as its repressive effect on apoptosis were abrogated via overexpressed TET3. Yes Overexpressed MIR22HG repressed the viability and proliferation but enhanced apoptosis of osteosarcoma cells, which was reversed by miR-629-5p upregulation.  34373436 hsa_circ_0005909 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Interaction(miRNA-338-3p/SOX4 Pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//EdU Staining//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay In this research, our group firstly showed that circ_0005909 expressions were distinctly increased in NSCLC specimens and cell lines. In the terms of mechanism, circ_0005909 could act as a sponge of miRNA-338-3p, and miRNA-338-3p could target SOX4. Clinical studies revealed that high circ_0005909 expressions were associated with poor prognosis of NSCLC patients. Yes Functionally, knockdown of circ_0005909 was observed to suppress the proliferation, metastasis, and drug resistance of NSCLC cells. 34413915 MIR22HG LncRNA Homo sapiens Glioma glioma tissues and cell lines regulation[miR-9/CPEB3 axis] CCK8//qRT-PCR//Wound Healing Assay The results showed that MIR22HG expression level was decreased but miR-9 expression level was elevated in glioma tissues and cell lines. Taken together, these findings confirmed that MIR22HG suppressed glioma development by inhibiting the miR-9/CPEB3 axis and provides a novel therapeutic strategy for glioma treatment. Yes Functionally, MIR22HG regulated the proliferation, invasion and migration of the glioma cell line by targeting miR-9. 33552275 hsa_circ_0011290 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues regulation[miR-1252/ FSTL1 signal pathway] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//Western Blot Aberrant over-expression of hsa_circ_0011290 was associated with advanced stage and unfavorable prognosis of PTC.Our study uncovered the oncogenic contributions of hsa_circ_0011290-miR-1252-FSTL1 in PTCs. Yes Knockdown of hsa_circ_0011290 greatly inhibited cell viability, proliferation and stimulated cell apoptosis in PTC cells. 32234499 hsa_circ_0016760 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue specimens and cell lines Interaction(miR-646/AKT3 ) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Circ_0016760 and AKT3 were highly expressed in NSCLC tissue specimens and cell lines. Circ_0016760 interacted with miR-646 and negatively regulated its expression. MiR-646 bound to the AKT3 3' untranslated region in NSCLC cells, and miR-646 overexpression-induced effects in NSCLC cells were partly overturned by the addition of AKT3 overexpression plasmid. Yes Circ_0016760 interference suppressed cell proliferation, migration, and invasion and promoted the apoptosis of NSCLC cells. Circ_0016760 interacted with miR-646 and negatively regulated its expression. 34658165 circRUNX1 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Interaction(MiR-296-3p/DDHD2 axis) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay CircRUNX1 was selected for its high expression in PTC, and circRUNX1 silencing was directly associated with the week potential for migration, invasion and proliferation of PTC in vivo and in vitro. MiR-296-3p was then confirmed to be regulated by circRUNX1 and to target DDHD domain containing 2 (DDHD2) by luciferase reporter assays. Yes CircRUNX1 was selected for its high expression in PTC, and circRUNX1 silencing was directly associated with the week potential for migration, invasion and proliferation of PTC in vivo and in vitro. 33479208 NEAT1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cell lines regulation[miR-4500/BZW1 axis] CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay miR?4500 expression levels were low, whereas NEAT1 expression levels were high in OC tissues and cell lines compared with control tissues and cell lines.Collectively, the present study suggested that NEAT1 modulated cell proliferation, colony formation, apoptosis, migration, invasion and glycolysis via the miR‑4500/BZW1 axis in OC; therefore, NEAT1 may serve as a therapeutic target for OC. Yes NEAT1 knockdown induced OC cell apoptosis, and inhibited OC cell proliferation, colony formation, migration, invasion and glycolysis. 32945505 NNT-AS1 LncRNA Homo sapiens Cholangiocarcinoma CCA tissue Regulation[NNT-AS1/miR-142-5p/HMGA2 axis] ISH//qRT-PCR//Luciferase Report Assay//Western Blot LncRNA NNT-AS1 was found highly expressed in CCA.Mechanistically, we demonstrated that NNT-AS1 might function as a ceRNA in regulating HMGA2 (high mobility group AT-hook 2) through competitively binding to miR-142-5p in CCA. Moreover, we showed that NNT-AS1 regulated epithelial-mesenchymal transition in CCA. Upregulated NNT-AS1 expression was tightly associated with clinical malignancies and predicted poor prognosis of CCA patients. Yes Functional studies showed that NNT-AS1 knockdown inhibited cell proliferation, migration and invasion of CCA cells in vitro. Conversely, NNT-AS1 overexpression showed the opposite biological effects. In a tumor xenograft model, we confirmed that NNT-AS1 knockdown could significantly inhibit the growth of CCA, while NNT-AS1 overexpression promoted CCA development. 31632521 MIR31HG LncRNA Homo sapiens Stomach Neoplasms GC cells Regulation[p21 and E-cadherin] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Transwell Assay LOC554202 expression was higher in GC cells than that of gastric mucosal cells (p<0.01). It could promote proliferative and migratory abilities by downregulating expression levels of p21 and E-cadherin in GC cells. Yes Overexpression of LOC554202 in MGC-803 cells enhanced proliferative and migratory abilities, but decreased protein expressions of p21 and E-cadherin (p<0.01). 30575909 MIR31HG LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-361-3p -YY1) qRT-PCR//Western Blot MIR31HG was up-regulated in CRC tissues and was associated with poorer prognosis of CRC patients. In addition, MIR3HG overexpression promoted YY1 mRNA and protein level, and forced overexpression of YY1 enhanced MIR31HG level. Overexpressing YY1 reversed the tumor-suppressive effect mediated by MIR31HG knockdown. miR-361-3p, which was inhibited by MIR31HG overexpression, repressed the malignant behaviors of CRC cells. miR-361-3p-mediated anti-tumor effects were mostly reversed by upregulating MIR31HG. Further mechanism studies illustrated that miR-361-3p targeted and negatively regulated the expression of YY1. Yes The in-vitro and in-vivo experiments confirmed that overexpressing MIR31HG heightened the proliferation, growth, invasion, glycolysis and lung metastasis of CRC cells as well as the angiogenesis of HUVECs. 34485123 NNT-AS1 LncRNA Homo sapiens Cholangiocarcinoma CCA tissue,cell lines Interaction[miR-485/BCL9] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay In this study, NNT-AS1 was expressed at high levels in CCA and closely associated with poor prognosis of patients with CCA.Moreover, NNT-AS1 directly bounded to miR-485 and further regulated BCL9. Finally, rescue assays verified that NNT-AS1 modulated the tumorigenesis of CCA by regulating miR-485. In this study, NNT-AS1 was expressed at high levels in CCA and closely associated with poor prognosis of patients with CCA Yes NNT-AS1 knockdown impaired cell proliferation, suppressed CCA cell migration and invasion, and restrained tumor growth in vitro. 31616187 MIR31HG LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer patients and cell line Expression(highly expressed) qRT-PCR//Wound Healing Assay//IHC//Western Blot In TCGA database, we found that MIR31HG was elevated in colorectal cancer patients. The patients with high MIR31HG expression had poor overall survival and disease-specific survival. Yes Besides, MIR31HG knockdown significantly impaired colorectal cancer cell migration, invasion, growth and colony formation. 35733512 MIR31HG LncRNA Homo sapiens Carcinoma, Hepatocellular HCC specimens and cell lines Interaction(miR-485-5p/BSG axis) qRT-PCR//Wound Healing Assay//ChIP In this study, we firstly reported that LOC554202 expression was distinctly upregulated in HCC specimens and cell lines. Mechanistically, LOC554202 competitively bound to miR-485-5p and prevented the suppressive effects of miR-485-5p on its target gene basigin (BSG), which finally led to HCC metastasis, EMT, and docetaxel chemoresistance. Our data demonstrated that FOXO3-induced LOC554202 contributed to HCC progression by upregulating BSG via competitively binding to miR-485-5p, which suggested that the regulation of the FOXO3/LOC554202/miR-485-5p/BSG axis may have beneficial effects in the treatment of HCC. Clinical assays indicated that increased LOC554202 expression had a diagnostic value for HCC patients and was positively associated with advanced stages and poor clinical prognosis. Yes Additionally, forkhead box O3(FOXO3) could bind directly to the LOC554202 promoter region and activate its transcription. Functionally, we observed that knockdown of LOC554202 suppressed the proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) progress of HCC cells, and promoted apoptosis. 33654226 MIR31HG LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer cells and tissues Expression[lower expressed] qRT-PCR In this study, a decreased expression of MIR31HG was found in bladder cancer cells and tissues, except in the basal subtype. Survival analysis showed that high expression of MIR31HG was associated with poor overall survival (OS) and disease-free survival (DFS) in patients with MIBC of basal subtype. Yes In vitro experiments revealed that knockdown of MIR31HG inhibits cell proliferation, colony formation, and migration in bladder cancer. 33334367 NEAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(FOXP3/PKM2 axis) qRT-PCR//RIP//Western Blot A series of experiments have shown that NEAT1 knockdown can inhibit the viability, proliferation, migration, and invasion of HCC cells; NEAT1 can bind FOXP3 to promote PKM2 transcription; PKM2 knockdown can inhibit the viability, proliferation, migration, and invasion of HCC cells; and PKM2 knockdown reversed the function of NEAT1. Yes A series of experiments have shown that NEAT1 knockdown can inhibit the viability, proliferation, migration, and invasion of HCC cells; NEAT1 can bind FOXP3 to promote PKM2 transcription; PKM2 knockdown can inhibit the viability, proliferation, migration, and invasion of HCC cells; and PKM2 knockdown reversed the function of NEAT1. 36185217 circPRKCI CircRNA Homo sapiens Thyroid Cancer, Papillary human PTC patients' tumors and cells Interaction(circ-PRKCI/miR-335/E2F3 ceRNA axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qPCR//RIP//MTT//Luciferase Report Assay Here, quantitative real-time PCR showed that expression of circ-PRKCI was abnormally upregulated in human PTC patients' tumors and cells, and higher circ-PRKCI might predict lymph node metastasis and recurrence. Molecularly, circ-PRKCI functioned as a sponge for miR-335 and miR-335 could further targeted E2F transcription factor-3 (E2F3), according to dual-luciferase reporter assay and RNA immunoprecipitation. Here, quantitative real-time PCR showed that expression of circ-PRKCI was abnormally upregulated in human PTC patients' tumors and cells, and higher circ-PRKCI might predict lymph node metastasis and recurrence.  Yes As a result, circ-PRKCI knockdown could suppress cell cycle progression of PTC cells and restrain the abilities of cell proliferation, colony formation, wound closure, invasion, glucose consumption and lactate production, accompanied with decreased levels of matrix metalloproteinase-2 (MMP2), MMP9 and Snail.Moreover, above-mentioned inhibition could be imitated by overexpressing microRNA-335-5p (miR-335). 33716239 MIR31HG LncRNA Homo sapiens Thyroid Neoplasms human thyroid cancer tissues and cells Interaction(miR-761/MAPK1 axis) In Vivo Experiment//Bioinformatics Analysis//Wound Healing Assay//Immunoblotting//EdU Staining//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay MIR31HG was overexpressed in human thyroid cancer, and its overexpression predicted poor prognosis. Mechanistically, MIR31HG targeted and regulated miR-761. Moreover, miR-761 was identified as a molecular mediator of MIR30HG function in regulating thyroid cancer cell behaviors. MAPK1 was established as a direct and functional target of miR-761 and MAPK1 knockdown phenocopied miR-761 overexpression in impacting thyroid cancer cell behaviors. MIR31HG was overexpressed in human thyroid cancer, and its overexpression predicted poor prognosis. Yes Suppression of MIR31HG impeded cell proliferation, invasion and migration, as well as promoted cell apoptosis in vitro, and diminished the growth of xenograft tumors in vivo. 35443670 NEAT1 LncRNA Homo sapiens Ovarian Neoplasms cell lines interaction[miR-1321] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Elevated expression of NEAT1 was observed in OC cell lines, and NEAT1 expression was found to be positively related to the expression of tight junction protein 3 (TJP3), which is important in cancer development.Thus, the present study demonstrated that NEAT1 regulates TJP3 expression by sponging miR‑1321 and enhances the epithelial‑mesenchymal transition, invasion and migration of OC cells. Yes Knockdown of NEAT1 attenuated the migration and invasion of OC cells, as well as increased miR?1321 expression and in turn led to the reduction of TJP3. 32945443 NNT-AS1 LncRNA Homo sapiens Osteosarcoma Interaction[suppressive miR-320a] CCK8//qRT-PCR//Western Blot In both in vitro and in vivo model, NNT-AS1 expression level significantly correlated with that of beta-catenin, RUNX2, IGF-1R, c-Myc, Cyclin D1 and MMP13 as well as Akt phosphorylation level, and inversely correlated with miR-320a expression. Transfection of miR-320a mimic significantly inhibiter the promoting effect of NNT-AS1 on cell proliferation, survival and mobility of U2OS cells, while miR-320 inhibitor partially rescued that of OS-732 cells. Yes NNT-AS1 overexpression significantly increased proliferation, survival and mobility of U2OS cells in vitro as well as its tumor formation ability in vivo, while NNT-AS1 knockdown showed opposite effect on OS-732 cells. 30489194 MIR31HG LncRNA Homo sapiens pancreatic ductal adenocarcinoma Expression(highly expressed) qRT-PCR//Western Blot In this study, a cancer genomics analysis predicted that MIR31HG overexpression was positively correlated with poorer disease-free survival of pancreatic ductal adenocarcinoma (PDAC) patients, which was associated with upregulation of genes related to TGFβ signaling and the EMT. In this study, a cancer genomics analysis predicted that MIR31HG overexpression was positively correlated with poorer disease-free survival of pancreatic ductal adenocarcinoma (PDAC) patients, which was associated with upregulation of genes related to TGFβ signaling and the EMT. Yes In vitro evidence demonstrated that TGFβ induced MIR31HG expression in PDAC cells, and knockdown of MIR31HG expression reversed TGFβ-induced EMT phenotypes and cancer cell migration. 35743003 NEAT1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer clinical tissue samples and cell lines Interaction(let-7 g/MEST/ATGL axis) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//IHC NEAT1 expression was elevated while let-7 g was decreased in ovarian cancer clinical tissue samples and cell lines. A negative correlation existed between NEAT1 and let-7 g, whereby NEAT1 competitively bound to let-7 g and consequently down-regulate let-7 g expression. In addition, let-7 g targeted mesoderm specific transcript (MEST) and inhibited its expression, leading to promotion of adipose triglyceride lipase (ATGL) expression and inhibition of ovarian cancer cell growth, migration, and invasion. However, the effect of let-7 g was abolished by overexpression of MEST. Yes Furthermore, silencing of NEAT1 decreased the xenograft tumor growth by decreasing MEST while up-regulating let-7 g and ATGL. 34416900 MIR31HG LncRNA Homo sapiens Nasopharyngeal carcinoma HNSC tissues and NPC tissues Regulation(PI3K/AKT signaling pathway) Western Blot//FISH//qRT-PCR//MTT//Colony Formation Assay//Bioinformatics Analysis MIR31HG was highly expressed in HNSC tissues and NPC tissues. Meanwhile, the association between high MIR31HG expression and aggressive clinicopathological traits was significant in NPC patients at tumor stage III-IV (T3-T4) and in those with lymph node metastasis 1-2 (N1-N2). Yes Silencing of MIR31HG suppressed NPC cell viability and colony formation, promoted apoptosis, and decreased the expressions of p-PI3K, and p-AKT. 740Y-P reversed the above effects of si-MIR31HG on NPC cells. Besides, MIR31HG expression was positively correlated with AKT1 mRNA expression in HNSC patients. 36347827 MIR31HG LncRNA Homo sapiens Glioblastoma GBM cell Regulation(STAT1/Wnt/β-catenin signaling pathway) Northern Blot//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining//ChIP In the present study, we detected strongly-expressed MIR31HG in GBM cells through RT-qPCR analysis. Mechanistically, STAT1 was found to be as a transcription factor and played a part in activating the transcription of MIR31HG with upregulating the expression of MIR31HG in GBM. Moreover, high MIR31HG level was confirmed to induce the activation of Wnt/β-catenin signaling pathway in a variety of cancers. From subcellular fractionation and western blot assays, it was displayed that MIR31HG activated Wnt/β-catenin signaling pathway through enhancing the nuclear translocation of β-catenin. Yes Through loss-of-function assays, we uncovered that MIR31HG exerted its oncogenic property in GBM through boosting cell proliferation and suppressing the apoptosis. 33940081 NEAT1 LncRNA Homo sapiens Ovarian Neoplasms OC cells Interaction( miR-365) qRT-PCR//Luciferase Report Assay//Western Blot LncRNA NEAT1 and FGF9 are over-expressed in OC cells. NEAT1 can down-regulate the expression of miR-365 while up-regulating that of FGF9. Dual-luciferase reporter assay determined that NEAT1 competes with FGF9 for binding to miR-365. Yes . Knockdown of NEAT1 or FGF9, or over-expression of miR-365 results in decreased proliferation rate and cell clones as well as inhibited angiogenesis and down-regulated expressions of VEGF, Ang-1 and MMP2. Over-expression of NEAT1 or knockdown of miR-365 can reverse the effect caused by FGF9 knockdown. 33545926 NEAT1 LncRNA Homo sapiens Urinary Bladder Neoplasms cell lines(SV-HUC-1) Regulation[ NEAT1/miR-410/HMGB1 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining Firstly, NEAT1 expression in bladder cancer cells was determined and it was displayed NEAT1 was significant elevated.By employing the bioinformatics analysis, we speculated that miR-410 was as a downstream target of NEAT1. Then, the targeting association between them was proved in our research and we implicated miR-410 was dramatically restrained in bladder cancer cells. Meanwhile, it was exhibited that miR-410 was negatively regulated by NEAT1. Apart from these, HMGB1 was speculated as a downstream target of miR-410. Dual-luciferase reporter assay was used to prove the correlation between miR-410 and HMGB1. Up-regulation of miR-410 restrained HMGB1 levels and NEAT1 can regulate HMGB1 level via sponging miR-410. Yes NEAT1 was knockdown and overexpressed in T24 and J82 cells. Then it was indicated that NEAT1 silence greatly inhibited bladder cancer cell proliferation with an increased ratio of apoptotic cells and severe cell cycle arrest. Overexpression of NEAT1 exhibited a reversed process in bladder cancer cells. NEAT1 knockdown inhibited bladder cancer growth while increase of NEAT1 promoted bladder cancer development in vivo. 31734579 MIR22HG LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cells Regulation[Wnt/β-catenin signaling pathway ] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay We first found that MIR22HG expression was significantly down-regulated in CCA tissues and cell lines. In summary, the results of the present study show that MIR22HG repressed cell proliferation, migration and invasion in CCA by negatively regulating the Wnt/β-catenin signaling pathway. MIR22HG may be a novel target for diagnosis and therapy in CCA. Yes Function experiments demonstrated that overexpression of MIR22HG inhibited cell proliferation, migration and invasion in CCA, whereas knockdown of MIR22HG caused the opposite result. 30856284 circβ-catenin CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Cancer and paracancerous normal tissues from 20 patients with NSCLC Expression [highly expressed] Western Blot//Wound Healing Assay//Co-IP//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay A prominently higher circβ-catenin expression was found in NSCLC tissues. Importantly, circβ-catenin was found to encode a peptide in NSCLC cells. Yes Silencing of circβ-catenin was able to inhibit NSCLC cell migrating, invasive, and proliferative phenotypes. Overexpression of circβ-catenin could enhance the migrating, invasive, and proliferative phenotypes of NSCLC cells. 34296778 MIR210HG LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues regulation[miR-503-5p/TRAF4 axis] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the current study, we discovered a new lncRNA MIR210HG which was upregulated in CC tissues through microarray. In conclusion, we demonstrated that MIR210HG promoted CC progression through regulating the MIR210HG/miR-503-5p/TRAF4 axis, indicating that MIR210HG might act as a novel insight into CC treatment. The upregulation of MIR210HG was associated with advanced FIGO stage, metastasis, and poor prognosis in CC patients. Yes Function assays showed that MIR210HG inhibition significantly suppressed the proliferation, invasion, and epithelial-mesenchymal transition (EMT) processes in CC and reduced tumor growth in vivo. 32087604 MIR210HG LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell line Interaction(miR-210/MYCN) In Vivo Experiment//IHC//Western Blot//Co-IP//Migration Assay//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay High expression of MIR210HG was confirmed in breast cancer. MIR210HG promoted breast cancer progression, which was mediated by its encoded miR-210. MIR210HG was regulated by IGF2BP1 mediated m6A modification. IGF2BP1 was confirmed highly expressed in breast cancer and induced both MIR210HG and miR-210 expression, which contributed to breast cancer progression. In addition, MIR210HG transcript was stabilized by IGF2BP1 and co-factor ELAVL1. IGF2BP1 was a direct target of MYCN via E-box binding motif. MYCN induced IGF2BP1 expression in breast cancer cells. MIR210HG and miR-210 expressions were also increased by MYCN. Yes MIR210HG promoted breast cancer progression, which was mediated by its encoded miR-210. MIR210HG was regulated by IGF2BP1 mediated m6A modification. IGF2BP1 was confirmed highly expressed in breast cancer and induced both MIR210HG and miR-210 expression, which contributed to breast cancer progression. In addition, MIR210HG transcript was stabilized by IGF2BP1 and co-factor ELAVL1. IGF2BP1 was a direct target of MYCN via E-box binding motif. MYCN induced IGF2BP1 expression in breast cancer cells. MIR210HG and miR-210 expressions were also increased by MYCN. 35346372 NEAT1 LncRNA Homo sapiens Parkinson Disease human neuroblastoma cell line SH-SY5Y and embryonic kidney epithelial cell line HEK-293 T Interaction(miR-124-3p) RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//ELISA We demonstrated that, in SH-SY5Y cells treated with MPP+, NEAT1 and PDE4B expression levels were raised, while miR-124-3p expression was repressed; Besides, miR-124-3p was confirmed as the direct target of NEAT1, and its down-regulation counteracted the impact of NEAT1 depletion on SH-SY5Y cells. Yes NEAT1 depletion or miR-124-3p overexpression increased the cell viability and suppressed cell injury. 33522352 NEAT1 LncRNA Homo sapiens Parkinson Disease SH-SY5Y cell Interaction(miR-107-5p) qRT-PCR//RNA Pull-Down//Western Blot Furthermore, the level of NEAT1 was positively correlated with MPP+ concentration.miR-107-5p was then considered as a NEAT1 putative target involving apoptosis and autophagy of SH-SY5Y cells. Interfering with NEAT1 efficiently facilitated the viability of SH-SY5Y cells and drastically suppressed autophagy and apoptosis of PD mice induced by MPTP- via elevating miR-107-5p level, which indicated that lncRNA NEAT1 acted as a latent therapeutic factor for PD treatment. Yes Interfering with NEAT1 in the present study promoted cellular proliferation and mediated SH-SY5Y cell apoptosis and autophagy treated with MPP+. 35587608 NEAT1 LncRNA Homo sapiens Leukemia, Myeloid, Acute cell lines Interaction[miR-23a-3p/SMC1A ] CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay The qRT-PCR illustrated that NEAT1 and SMC1A expression was decreased but that miR-23a-3p expression was increased in primary AML cells and THP-1 cells compared with that in normal cells. Flow cytometry showed that the upregulation of NEAT1 and SMC1A or repression of miR-23a-3p promoted apoptosis and affected the cell cycle. NEAT1 repressed the expression of miR-23a-3p, and therefore promoted SMC1A, which in turn suppressed myeloid leukemia cell proliferation and enhanced apoptosis. Yes The CCK-8 assay showed that the overexpression of NEAT1 and SMC1A or repression of miR-23a-3p inhibited cell proliferation. 30246348 NEAT1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML tissues and cells regulation[NEAT1/miR-338-3p axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay NEAT1 and CREBRF were down-regulated in AML tissues and cells. NEAT1/miR-338-3p axis repressed the AML progression through regulating CREBRF, which might afford a favorable perspective for the AML treatment molecularly. Yes NEAT1 up-regulation suppressed cell growth, migration and invasion but enhanced apoptosis of AML cells. 32280304 MIR210HG LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[binding to DNMT1] CCK8//Colony Formation Assay//Transwell Assay MIR210HG was highly expressed in NSCLC tissues not only in GSE30219 dataset but also in our collected NSCLC tissues.MIR210HG could recruit DNMT1, thereafter promoting methylation of CACNA2D2 promoter region. MIR210HG expression was correlated to tumor stage and lymph node metastasis of NSCLC patients. Besides, lower disease-free survival (DFS) and overall survival (OS) were found in NSCLC patients with high-level MIR210HG compared with those with low-level MIR210HG. Yes In vitro experiments demonstrated that MIR210HG knockdown remarkably inhibited proliferation and migration of NSCLC cells. 31190878 circRAPGEF5 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues,cell lines Interaction[miR-198/FGFR1] Western Blot//qPCR//CCK8//FISH//Luciferase Report Assay The results showed that circRAPGEF5 was Expression[Expression[up-expression]-expression]regulated in PTC tissues and cell lines. Luciferase reporter assays confirmed that circRAPGEF5 interacted with miR-198 and that miR-198 interacted with the 3' UTR of FGFR1 to Expression[down-expression]regulate its expression. Yes "circRAPGEF5 knockExpression[down-expression] inhibited cell proliferation, migration, and invasion in vitro; and circRAPGEF5 silencing Expression[down-expression]regulated fibroblast growth factor receptor 1 (FGFR1) expression by ""sponging"" miR-198, sExpression[Expression[up-expression]-expression]pressing the aggressive biological behaviors of PTC." 30785065 MIR210HG LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue samples and cells Expression[highly expressed] qRT-PCR In results of our research, MIR210HG expression was increased in HCC tissue samples and cells compared with paired adjacent normal liver tissue samples and normal liver cell line respectively, and a good marker to discriminate HCC tissues from non-tumorous tissues. MIR210HG high-expression was correlated advanced clinical stage, big tumor size, present vascular invasion and unfavorable histological differentiation. The survival analysis from our cohort and TCGA cohort consistently suggested that HCC patients with MIR210HG high-expression had poorer prognosis than HCC patients with MIR210HG low-expression. Furthermore, univariate and multivariate Cox regression analyses showed that MIR210HG high-expression was an independent unfavorable prognostic factor for overall survival in HCC patients. Yes The in vitro study showed that silencing of MIR210HG depressed HCC cell proliferation, migration and invasion. 30841443 NONHSAG053901 LncRNA Mus musculus Diabetic Nephropathies renal tissue,mesangial cells Interaction[stimulating Egr-1/TGF-β mediated renal inflammation] qRT-PCR In this study, we revealed that the expression of NONHSAG053901 was drastically elevated in both DN mouse model and mesangial cells (MCs). These results together suggested that NONHSAG053901 promoted proinflammatory cytokines via stimulating Egr-1/TGF-β mediated renal inflammation. Yes It was found that overexpression of NONHSAG053901 remarkably promoted inflammation, fibrosis and proliferation in MCs. 30927260 MIR22HG LncRNA Homo sapiens Prostatic Neoplasms prostate cancer cells Interaction(miR-9-3p) Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//IF Indeed, low MIR22HG expression was discovered in prostate cancer cells. In addition, MIR22HG was identified as a sponge of miR-9-3p and the impacts of MIR22HG overexpression on cell proliferation and apoptosis were partly hindered by miR-9-3p overexpression. Yes Subsequently, in vitro loss-of-function studies revealed that MIR22HG overexpression suppressed cell proliferation but promoted cell apoptosis, accompanied with a reduction in Ki67 and Bcl-2 expressions, as well as an elevation in Bax and cleaved caspase 3 expressions. 35611601 MIR210HG LncRNA Homo sapiens Uterine Cervical Neoplasms CSCC tissues Interaction(PGK1) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In the current study, we identified a hypoxia-induced lncRNA MIR210HG was excessively expressed in CSCC tissues and regulated by human papillomavirus (HPV) type 16 E6 and E7 via hypoxia-inducible factor 1α (HIF-1α).Mechanistically, the depletion of MIR210HG or HIF-1α decreased each other's expression level, while silencing MIR210HG or HIF-1α respectively downregulated the expression levels of phosphoglycerate kinase 1 (PGK1), one of key metabolic enzymes in the glycolysis pathway. Furthermore, decreased expression of PGK1 by HIF-1α knockdown was reversed through the overexpression of MIR210HG. Yes Functional assays revealed the role of MIR210HG in promoting proliferation, migration and invasion of CSCC cells in vitro under normoxia as well as hypoxia conditions. Meanwhile, stable MIR210HG silencing dramatically repressed tumor growth and pulmonary metastasis in vivo. 35812055 circMAN1A2 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC specimens and three PTC cell lines Interaction(miR-449a/MTDH ) In Vivo Experiment//IHC//Western Blot//Bioinformatics Analysis//Transfection//Wound Healing Assay//Invasion Assay//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay CircMAN1A2 expression was elevated in PTC specimens and three PTC cell lines relative to adjacent normal specimens and Nthy-ori 3-1 cell line. CircMAN1A2 acted as a molecular sponge of miR-449a, and circMAN1A2 knockdown suppressed PTC development partly through upregulating miR-449a. MiR-449a bound to the 3' untranslated region of MTDH, and miR-449a restrained PTC progression partly through down-regulating MTDH. Yes CircMAN1A2 silencing inhibited the proliferation and motility of PTC cells. CircMAN1A2 interference suppressed PTC progression in vivo . 36066401 MIR210HG LncRNA Homo sapiens Glioma glioma tissues and cells Interaction(miR-377-3p/LMX1A) qRT-PCR//Luciferase Report Assay LncRNA MIR210HG was elevated in glioma tissues and cells and inhibition of lncRNA MIR210HG reduced the proliferation potential of glioma cells. LncRNA MIR210HG targeted and inhibited miR-377-3p and miR-377-3p targeted and inhibited LMX1A transcription. miR-377-3p downregulation or LMX1A overexpression reversed the inhibition of silencing lncRNA MIR210HG on glioma cell proliferation. Yes LncRNA MIR210HG was elevated in glioma tissues and cells and inhibition of lncRNA MIR210HG reduced the proliferation potential of glioma cells. LncRNA MIR210HG targeted and inhibited miR-377-3p and miR-377-3p targeted and inhibited LMX1A transcription. miR-377-3p downregulation or LMX1A overexpression reversed the inhibition of silencing lncRNA MIR210HG on glioma cell proliferation. 36197580 NEAT1 LncRNA Homo sapiens Leukemia, Myeloid, Acute leukemia stem cells Expression(lower expressed) qRT-PCR//Western Blot//FISH NEAT1_1 is downregulated in leukemia stem cells (LSCs) and its decreased expression correlates with recurrence in AML patients. Mechanistically, NEAT1_1 is released from the nucleus into the cytoplasm of AML cells, regulated by transcription factor C/EBPβ and nuclear protein NAP1L1. Cytoplasmic NEAT1_1 interacts with Wnt component DVL2 and E3 ubiquitin ligase Trim56, facilitates Trim56-mediated DVL2 degradation, and thus suppresses Wnt signaling. NEAT1_1 is downregulated in leukemia stem cells (LSCs) and its decreased expression correlates with recurrence in AML patients. Yes It is demonstrated that NEAT1_1 suppresses leukemogenesis and LSC function but is dispensable for normal hematopoiesis. 34609794 circLPAR1 CircRNA Homo sapiens Alzheimer Disease AD patients and CHP-212 and IMR-32 cells Interaction(miR-212-3p/ZNF217 feedback loop) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA CircLPAR1 was highly expressed in AD patients and Aβ25-35-stimulated CHP-212 and IMR-32 cells. Mechanistically, circLPAR1 competitively bound to miR-212-3p to elevate its target ZNF217. Yes Knockdown of circLPAR1 suppressed Aβ25-35-induced neuronal apoptosis, inflammation, and oxidative stress. 34403662 hsa_circ_10720 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell lines (HCC44, A549, H23 and H1299) Expression [highly expressed] Western Blot//Transfection//Wound Healing Assay//qRT-PCR//cell invasion assay//IF  Circ-10720 was overexpressed in HCC44 and A549 and underexpressed in H23 and H1299 NSCLC cell lines in comparison to BEAS2B normal immortalized lung cell line.   high levels of circ-10720 had shorter median TTR than those with low levels Yes  CircRNA knockdown in the two circ-10720 overexpressing cell lines was associated with a decrease of Vimentin (VIM) and an increase of E-cadherin (CDH1) protein levels, loss of mesenchymal phenotype, and a significant reduction of migration and invasion capacity. After silencing circ-10720, the apoptosis rate increased and the proliferation was significantly reduced.  34012794 hsa_circ_0005835 CircRNA Homo sapiens Alzheimer Disease NSC Interaction(miR-576-3p) qRT-PCR//Luciferase Report Assay In our study, we found that circ_0005835 was upregulated in AD patients and cell models. Knockdown of circ_0005835 could downregulate neuroinflammation in BV2 cells. Moreover, knockdown of circ_0005835 promoted neural stem cells (NSC) proliferation and differentiate to neuron. These data mean that circ_0005835 plays important role in the development of AD. The miR-576-3p expression in serum was downregulated in the AD group compared to the health control group. Consistently, the level of circ_0005835 was overexpressed in the Aβ-treated in both SH-SY5Y and BV2 cells. Moreover, the expression of miR-576-3p was negatively correlated with circ_0005835 in AD patients. In addition, we performed the rescued experiments to show that knockdown of circ_0005835 could downregulate neuroinflammation through sponging miR-576-3p in BV2 cells. Inhibition of circ_0005835 promoted NSC proliferation and differentiate to neuron via sponging miR-576-3p. These data suggested that circ_0005835 promoted AD development through regulating miR-576-3p expression. Yes Knockdown of circ_0005835 could downregulate neuroinflammation in BV2 cells. Moreover, knockdown of circ_0005835 promoted neural stem cells (NSC) proliferation and differentiate to neuron. These data mean that circ_0005835 plays important role in the development of AD. 35060046 NEAT1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues Interaction[RELA/NEAT1/miR-302a-3p/RELA feedback loop ] qRT-PCR RELA and NEAT1 expression were upregulated in PDAC tissues, particularly in PDAC tissues with lymph node metastasis, and their expression correlated with clinical parameters.In summary, RELA, NEAT1, and miR-302a-3p form a feedback loop in PDAC to modulate PDAC cell proliferation and migration. RELA and NEAT1 expression were upregulated in PDAC tissues, particularly in PDAC tissues with lymph node metastasis, and their expression correlated with clinical parameters. Yes RELA overexpression promoted PDAC cell proliferation and migration, which could be partially attenuated by the NEAT1 knockdown. 30362505 NOC2L-4.1 LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Interaction[miR-630/YAP1 pathway] CCK8//qRT-PCR//Luciferase Report Assay Quantitative reverse transcription-polymerase chain reaction detection shows that compared with human normal cervical epithelial cell, the expression of lncRNA NOC2L-4.1 was significantly increased and the expression of miR-630 was decreased in cell lines of cervical cancer. miR-630 specific inhibitor treatment reversed the inhibitory effect of lncRNA NOC2L-4.1 on cell proliferation and migration. Further studies also found that yes-associated protein 1 (YAP1) was the target of miR-630. Overexpression YAP1 suppressed miR-630 overexpression induced cell proliferation and inhibition of migration. Tumors induced by implantation of lncRNA NOC2L-4.1-knockdown Hela cells in nude mice showed that lncRNA NOC2L-4.1 silencing decreased the growth of tumors in both volume and weight by regulation of miR-630/YAP1. Taken together, our study reveals the important role of lncRNA NOC2L-4.1/miR-630/YAP1 regulatory network in cervical cancer, which provides new insights concerning the pathogenesis of cervical cancer. Yes The in vitro study found that downregulation of lncRNA NOC2L-4.1 suppressed cervical cancer cell migration (transwell assays) and proliferation (cell counting kit-8 and cloning formation assays). 31099044 NNT‑AS1 LncRNA Homo sapiens Colorectal Neoplasms serum Interaction(miR‑496/RAP2C axis) qRT-PCR//Western Blot The serum levels of NNT‑AS1 were significantly upregulated in patients with CRC compared with healthy subjects (P<0.05). Furthermore, the NNT‑AS1 levels were significantly decreased in postoperative samples compared with preoperative samples (P<0.01). In addition, it was also identified that NNT‑AS1 was upregulated in CRC exosomes (P<0.01), whereas no significant difference was observed in NNT‑AS1 levels between serum and exosomes. It was also identified that NNT‑AS1 exerted its effects via regulation of the microRNA‑496/Ras‑related protein Rap‑2c axis. Yes Silencing of NNT?AS1 inhibited the proliferation, migration and invasion of CRC cells. 34132374 circFAT1(e2) CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung  NSCLC tissues and cell lines Interaction(miR-30e-5p-USP22 axis ) Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay circFAT1(e2) was significantly upregulated in NSCLC tissues and cell lines. Yes circFAT1(e2) gene knockdown could significantly inhibit the proliferation, migration, and invasion of NSCLC cells. Loss of function testing found that circFAT1(e2) functioned as an oncogene in NSCLC cells. In addition, circFAT1(e2) acted as a ceRNA to spongy miR-30e-5p, which led to the increase in USP22 and promoted cell growth. 33884267 NNT-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissue and cell lines interaction[miR-424/E2F1] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Results revealed that NNT-AS1 expression level was significantly up-regulated in GC tissue and cell lines compared with adjacent normal tissue and normal cell lines. In conclusion, our study indicates that NNT-AS1 sponges miR-424/E2F1 to facilitate GC tumorigenesis and cycle progress, revealing the oncogenic role of NNT-AS1 for GC. The ectopic overexpression of NNT-AS1 indicated the poor prognosis of GC patients. Yes In vitro experiments validated that NNT-AS1 knockdown suppressed the proliferation and invasion ability and induced the GC cell cycle progression arrest at G0/G1 phase. In vivo xenograft assay, NNT-AS1 silencing decreased the tumour growth of GC cells. 30006956 NEAT1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues,cell lines Interaction[sponging miR-34a-5p to mediate HOXA13] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay Our results demonstrated a high expression of NEAT1 in osteosarcoma tissues and cells. Besides, NEAT1 could positively regulate the expression of HOXA13 by competing with miR-34a-5p. Yes Overexpression of NEAT1 markedly accelerated proliferative and reduced apoptosis potentials of osteosarcoma cells. 31044561 NNT-AS1 CircRNA Homo sapiens Lung Neoplasms lung cancer tissues and cells regulation[NNT-AS1/miR-3666/E2F2 axis] Western Blot//qPCR//Flow Cytometry//MTT//PCR//IF NNT-AS1 and E2F2 were upregulated, but miR-3666 was downregulated in lung cancer tissues and cells.NNT-AS1 participated in the progression of lung cancer through NNT-AS1/miR-3666/E2F2 regulatory axis at least in part. Yes NNT-AS1 knockdown attenuated proliferation and invasion but enhanced apoptosis of lung cancer cells, while miR-3666 inhibition reversed these effects. 31957837 NEAT1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction[miR-186-5p/HIF-1α ] qRT-PCR In the present study, we found that NEAT1 expression was significantly upregulated in OS tissues and cell lines.In addition, our studies showed that miR-186-5p was a downstream target of NEAT1 in OS. Functionally, miR-186-5p suppressed the proliferation, invasion, and EMT process of OS cells. Furthermore, our data revealed that HIF-1α was a downstream target of miR-186-5p and that NEAT1 could exert its tumor oncogenic roles on OS cells via the miR-186-5p/HIF-1α axis. Taking our results together, we elucidated that the NEAT1/miR-186-5p/HIF-1α axis might be a therapeutic approach for the treatment of OS. High NEAT1 expression was closely associated with advanced clinicopathologic features and poor overall survival of patients with OS. Yes Using in vitro function assay, we found that NEAT1 could promote the proliferation, invasion, and epithelial-mesenchymal transition (EMT) process of OS cells. NEAT1 could also promote OS cell growth in vivo. 30485482 MIR22HG LncRNA Homo sapiens Colorectal Neoplasms CRC sample and CRC cells Expression(lower expressed) In Vivo Experiment//Western Blot//qRT-PCR//MTT//Cell Apoptosis Assay The qPCR and ISH assay revealed that MIR22HG was downregulated in CRC sample compared with in normal tissue. MIR22HG was also significantly downexpressed in CRC cells compared with that in normal colonic epithelial cell line. Yes Overexpression of MIR22HG inhibited the growth, migration ability, and invasiveness of CRC cell in vitro. In addition, MIR22HG suppressed the epithelial-mesenchymal transition (EMT) and induced the apoptosis of human CRC cell. Moreover, the authors demonstrated that MIR22HG inhibited the tumor growth of CRC cell and regulated the expression of EMT markers (E-cadherin and N-cadherin) in vivo. 33493419 NEAT1 LncRNA Homo sapiens Osteosarcoma cell lines(KHOS, 143B, SAOS‐2, SOSP‐9697,MG‐63) Interaction[miR-339-5p/TGF-β1 pathway] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay "We observed that NEAT1 was significantly increased in OS cells compared with hFOB 1.19 cells (Figure 1a). MiR-339-5p was significantly decreased in OS cells, and its overexpression can remarkably repress the OS proliferation. These results indicated that NEAT1 could function as a tumor oncogene in OS by inhibiting miR-339-5p in vitro. Then, the following assays validated that transforming growth factor β1 (TGF-β1) can act as a functional target of miR-339-5p in OS cells. Finally, we indicated that NEAT1 could mediate TGF-β1 expression by competitively sponging miR-339-5p. NEAT1 induced OS cell proliferation and cell mobility by binding to miR-339-5p and increasing TGF-β1 in OS. It was demonstrated in our study that lncRNA NEAT1 could impede miR-339-5p expression to maintain the expression of TGF-β1, which led to the development of OS. Our findings implied that the novel identified NEAT1/miR-339-5p/TGF-β1 axis might be a new molecular pathway or therapeutic target for OS diagnosis and treatment." Yes "The CCK8 assay was used to detect whether NEAT1 inhibition could influence OS cell growth. It was observed that LV‐shNEAT1 could dramatically inhibit cell survival, especially at 72 hr, and induce OS cell apoptosis (Figure 2c–e)." 30203547 MIR22HG LncRNA Homo sapiens Adenocarcinoma Of Esophagus cell lines Regulation[ STAT3/c-Myc/FAK signaling] Cell Proliferation Assay//qRT-PCR//Colony Formation Assay//Western Blot Mechanistically, MIR22HG silencing decreased the expression of STAT3/c-Myc/p-FAK proteins and induced apoptosis in EAC cell lines. Yes In this study, abrogation of MIR22HG inhibited cell proliferation, colony formation, invasion and migration in EAC 3 cell lines (OE33, OE19 and FLO-1). 31291201 NNT-AS1 LncRNA Homo sapiens Lung Neoplasms NSCLC tissues and cell lines Regulation[NNT-AS1/miR-129-5p axis] qRT-PCR In the present study, we showed that the expression of NNT-AS1 was upregulated in non-small cell lung cancer (NSCLC) tissues and cell lines.Thus, our study indicated that lncRNA NNT-AS1 exerted functions in NSCLC via altering NNT-AS1/miR-129-5p axis which provided a novel therapeutic target for lung cancer treatment. High NNT-AS1 expression was associated with advanced tumor stage, and lymph node metastasis of NSCLC patients. Yes In vitro function assays showed that NNT-AS1 inhibition could significantly reduce lung cancer cells proliferation and invasion ability. 29857296 NNT-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-22-3p/YAP1 axis] RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay We found that the levels of NNT-AS1 and YAP1 were enhanced, while miR-22-3p expression was decreased in NSCLC tissues and cells.NNT-AS1 facilitated proliferation, migration, invasion and EMT of NSCLC cells by sponging miR-22-3p and regulating YAP1 expression, which might provide a potential biomarker and therapeutic target for NSCLC. High NNT-AS1 expression was correlated with poor prognosis. Yes NNT-AS1 knockdown impeded proliferation, migration, invasion and EMT of NSCLC cells. 31923353 MIR22HG LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma papillary carcinomas tissues ,cell lines Regulation[miR-24-3p/p27kip1 axis ] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay LncRNA MIR22HG and p27kip expressed low while miR-24-3p expressed high in thyroid papillary carcinomas and cells.MIR22HG inhibited cell growth through modulating p27kip1 by decreasing miR-24-3p expression in thyroid papillary carcinomas, providing a new modulate mechanism and therapeutic targets in thyroid papillary carcinomas. Yes Overexpression of MIR22HG inhibited cell proliferation, migration and invasion, whereas promoted cell apoptosis in thyroid papillary carcinomas cells. 31298336 Mir22hg LncRNA Mus musculus Osteoporosis bone marrow mesenchymal stem cells regulation[PTEN/ AKT pathway] qRT-PCR We found the expression of MIR22HG was significantly decreased in mouse BMSCs from the osteoporotic mice and it was upregulated during the osteogenic differentiation of human BMSCs. Mechanistically, MIR22HG promoted osteogenic differentiation by downregulating phosphatase and tensin homolog (PTEN) and therefore activating AKT signaling. Yes Overexpression of MIR22HG in human BMSCs enhanced osteogenic differentiation, whereas MIR22HG knockdown inhibited osteogenic differentiation both in vitro and in vivo. 32732881 MIR4435‑2HG LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues Interaction( miR‑383‑5p/RBM3 axis) qRT-PCR In tShe present study, we observed that MIR4435‑2HG expression was markedly upregulated in HNSCC tissues based on a Gene Expression Profiling Interactive Analysis dataset. This result was further confirmed in HNSCC tissues and cell lines using quantitative real‑time polymerase chain reaction. Furthermore, MIR4435‑2HG affected HNSCC cell proliferation and migration and EMT by modulating the microRNA miR‑383‑5p to positively regulate the protein expression level of RNA‑binding motif protein 3 (RBM3). In addition, the high expression level of MIR4435‑2HG was significantly associated with poor disease‑free survival and overall survival in all HNSCC cases and was associated with advanced tumor‑metastasis‑node stage and poor prognosis. I Yes In vitro and in vivo assays demonstrated that MIR4435‑2HG knockdown suppressed HNSCC cell proliferation and invasion, epithelial‑mesenchymal transition (EMT), and tumor growth as determined by Cell Counting Kit‑8, Transwell assays and western blotting. 33846802 hsa_circ_0039411 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Regulation[miR-1179/ABCA9 and miR-1205/MTA1 signaling pathways] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Hsa_circ_0039411 was identified as enhanced in PTC tissues/cells.The mechanism exploration showed that hsa_circ_0039411 functioned as a sponge for miR-1179 and miR-1205 to elevate ATP-binding cassette transporter A9 (ABCA9) and metastasis-associated 1 (MTA1) expression at the post-transcriptional level, respectively. Further investigation confirmed that the functions of hsa_circ_0039411 are dependent on its modulation of ABCA9 and MTA1 in PTC cells. Yes Gain-of-function experiments indicated that hsa_circ_0039411 facilitated PTC cell growth, migration, and invasion and inhibited cell apoptosis. Knockdown of hsa_circ_0039411 caused the opposite effects mentioned above. 31270819 NEAT1 LncRNA Homo sapiens Osteosarcoma U2OS cells Interaction(miR-483/STAT3 axis ) qRT-PCR//Western Blot The knockdown of NEAT1 in transplanted U2OS cells impaired the liver and lung metastases of osteosarcoma in nude mice. Moreover, NEAT1 silencing inhibited the mesenchymal- epithelial transition (MET) of osteosarcoma at metastasis sites. Yes The knockdown of NEAT1 in transplanted U2OS cells impaired the liver and lung metastases of osteosarcoma in nude mice. Moreover, NEAT1 silencing inhibited the mesenchymal- epithelial transition (MET) of osteosarcoma at metastasis sites. 33546665 NNT-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[miR-142-5p/SOX4/Wnt/β-catenin signaling pathway] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay NNT?AS1 and SOX4 were upregulated, whereas miR?142?5p was downregulated in GC tissues and cells compared with normal tissues and cells. Collectively, the present study indicated that NNT‑AS1 knockdown decreased GC cell proliferation, migration and invasion, and induced GC cell apoptosis by regulating the miR‑142‑5p/SOX4/Wnt/β‑catenin signaling pathway axis. Yes Both NNT?AS1 and SOX4 knockdown inhibited GC cell proliferation, migration and invasion, and enhanced GC cell apoptosis. 32468065 hsa_circ_0010235 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Fifty-three NSCLC patients Interaction(miR-338-3p) In Vivo Experiment//Western Blot//Transfection//Invasion Assay//Migration Assay//CCK8//Flow Cytometry//EdU Staining//Transwell Assay Expression of circ_0010235 was increased in human NSCLC tissues and cells, accompanied with miR-338-3p downregulation and KIF2A upregulation. Essentially, circ_0010235 could sponge miR-338-3p via target binding, and miR-338-3p downstream targeted KIF2A. Yes Functionally, exhaustion of circ_0010235 induced apoptosis rate of NSCLC cells and curbed cell viability, EdU incorporation, migration rate and invasion rate, accompanied with higher E-cadherin and lower N-cadherin expression. 34024242 NNT-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Interaction[suppressing miR-363] CCK8//qRT-PCR//Luciferase Report Assay In our study, we indicated that NNT-AS1 expression was upregulated in GC samples compared with the nontumor tissues. We also showed that NNT-AS1 expression was upregulated in the GC cell lines.These results indicated that lncRNA NNT-AS1 acted as an oncogene in the development of GC partly by inhibiting miR-363 expression. Yes Furthermore, we reported that elevated expression of NNT-AS1 promoted GC cell proliferation, cycle, and invasion partly by suppressing miR-363 expression. 30324628 NEAT1 LncRNA Homo sapiens Neoplasms Cancer-associated fibroblasts cells Interaction(miR-26a/b-5p-STAT3-YKL-40 axis) ChIP//Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//IF In our study, NEAT1 and YKL-40 were up-regulated, while miR-26a/b-5p was down-regulated in EC tissues. Moreover, NEAT1 expression was increased in CAF-exosomes compared with that in NF-exosomes. Yes More importantly, exosomal NEAT1 accelerated in vivo tumor growth via miR-26a/b-5p-STAT3-YKL-40 axis.  34153644 hsa_circ_0002111 CircRNA Homo sapiens Thyroid Cancer, Papillary 82 PTC tissue and adjacent normal tissue samples Expression [highly expressed] Transfection//Wound Healing Assay//Invasion Assay//CCK8//qRT-PCR//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay We found that the expression of hsa_circ_0002111 was significantly up-regulated in PTC tissues compared with adjacent non-cancerous tissues (P < 0.0001). Expression of hsa_circ_0002111 was also associated with advanced TNM stage and lymph-node metastasis of patients with PTC. The area under the receiver operating characteristic curve was 0.833. Yes Further, cell function assays showed that hsa_circ_0002111 inhibition significantly suppressed the proliferation and invasion abilities of PTC cells in vitro. 33718243 hsa_circ_0000190 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung plasma Regulation(sPD-L1) Cell Proliferation Assay//In Vivo Experiment//qRT-PCR//Western Blot Our results unraveled that hsa_circ_0000190 facilitated the tumorigenesis and immune evasion of NSCLC by upregulating sPD-L1 expression, potentially developing a different aspect in elucidating the molecular immunopathogenesis of NSCLC. Yes Our results unraveled that hsa_circ_0000190 facilitated the tumorigenesis and immune evasion of NSCLC by upregulating sPD-L1 expression, potentially developing a different aspect in elucidating the molecular immunopathogenesis of NSCLC. 35008490 MIR4435-2HG LncRNA Homo sapiens Colorectal Neoplasms CRC tissue regulation[miR-206/YAP1 Axis] qRT-PCR//Luciferase Report Assay MIR4435-2HG was highly expressed in CRC tissue in contrast with that in regular tissues and displayed relations to poor prognosis.MIR4435-2HG promoted CRC growth and metastasis through miR-206/YAP1 axis and is likely to play prognostic marker roles and be therapeutically targeted in CRC. MIR4435-2HG was highly expressed in CRC tissue in contrast with that in regular tissues and displayed relations to poor prognosis. Yes MIR4435-2HG knockdown could suppress CRC cell proliferation, invasion, and migration. Moreover, MIR4435-2HG knockdown inhibited CRC growth and liver metastasis in vitro. 32154166 hsa_circ_000864 CircRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues interaction[Binding to miR-361-3p] RNA Pull-Down//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay CircRNA_000864 and BTG2 were poorly expressed, and miR-361-3p was highly expressed in the pancreatic cancer tissues. Conjointly, our findings elicited that the overexpression of circRNA_000864 could promote BTG2 expression to inhibit pancreatic cancer development by binding to miR-361-3p, which represents an appealing therapeutic target for the treatment of pancreatic cancer. Yes Cell proliferation, migration, and invasion were inhibited, and the cell cycle arrest and apoptosis were stimulated after overexpression of circRNA_000864 or BTG2 or downregulation of miR-361-3p. Overexpression of circRNA_000864 or downregulation of miR-361-3p also decreased the tumor growth in vivo. 33425718 MT1JP LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC clinical samples and cells Interaction(miR-138/HIF-1α axis) Western Blot//Transfection//Migration Assay//qRT-PCR//Cell Proliferation Assay//IHC//Transwell Assay We observed that MT1JP was downregulated in TNBC. MT1JP was positively correlated with miR-138 but negatively correlated with HIF-1α in TNBC tissues. In TNBC cells, upregulation of miR-138 and downregulation of HIF-1α were observed after overexpression of MT1JP. In addition, overexpression of miR-138 resulted in downregulation of HIF-1α but did not affect the expression of MT1JP. Yes Decreased proliferation rate of TNBC cells was observed after overexpression of MT1JP and miR-138. HIF-1α increased cell proliferation and migration. HIF-1α also suppressed the role of MT1JP and miR-138 in TNBC cell proliferation and migration. 35703312 hsa_circ_001982 CircRNA Homo sapiens Carcinoma, Adenoid Cystic cell lines Expression[highly expressed] qRT-PCR qRT-PCR confirmed hsa_circRNA_092556, hsa_circRNA_101379, and hsa_circRNA_001982 up-regulation in SACC-LM. miR-181a-5p was down-regulated in SACC-LM and correlated with up-regulated hsa_circRNA_001982. Yes Wound healing and transwell assays indicated that silencing hsa_circRNA_001982 inhibited the migration and invasion of the SACC-LM cells. Furthermore, over-expression of hsa_circRNA_001982 promoted the migration and invasion of SACC-83 cells. 33237453 MT1JP LncRNA Homo sapiens Osteosarcoma OS tissues,Plasma regulation[miR-646,FGF2 ] qRT-PCR//Transwell Assay The authors found that MT1JP was significantly downregulated in OS tissues than in adjacent noncancer tissues.In addition, plasma MT1JP was also downregulated in OS patients than in healthy controls. In conclusion, MT1JP might downregulate FGF2 through miR-646 to inhibit OS cell migration and invasion. The lower plasma levels of MT1JP in OS patients distinguished early stage OS patients from healthy controls. miR-646 was positive, but FGF2 was negatively correlated with MT1JP across OS tissues. Yes MT1JP and miR-646 overexpression inhibited the migration and invasion of OS cells. 32196384 MT1JP LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cancer tissues Interaction(miR-32/PTEN) CCK8//qRT-PCR//Western Blot It was found that MT1JP was downregulated in HCC cancer tissues compared with that in non-cancer tissues. The expression of MT1JP in HCC tissues was positively associated with PTEN and negatively associated with miR-32. Overexpression of MT1JP increased the expression levels of PTEN and decreased the expression levels of miR-32. Survival analysis showed that patients with low MT1JP expression levels exhibited a significantly higher 5-year overall survival rate compared with patients with high MT1JP levels. Yes Overexpression of miR-32 did not affect the expression of MT1JP but decreased the expression levels of PTEN and attenuated the effect of overexpression of MT1JP on the expression of PTEN. Overexpression of MT1JP and PTEN decreased the proliferation of HCC cells. 34188706 hsa_circ_0000644 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(miR-671-5p/ANXA2 axis) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay Circ_0000644 and ANXA2 expression was significantly upregulated, while miR-671-5p was downregulated in PTC tissues and cells when compared with control groups. In addition, circ_0000644 acted as a miR-671-5p sponge and mediated PTC cell tumor properties through miR-671-5p. ANXA2 was identified as a target gene of miR-671-5p, and its overexpression relieved miR-671-5p-induced effects in PTC cells. Furthermore, circ_0000644 depletion inhibited ANXA2 production by combining with miR-671-5p. Yes Circ_0000644 knockdown inhibited PTC cell proliferation, tube formation, migration, and invasion, but induced apoptosis in vitro. Moreover, circ_0000644 knockdown led to delayed tumorigenesis in vivo. 36224454 MIR503HG LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-224-5p/TUSC3 signaling ) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Transwell Assay LncRNA MIR503HG and TUSC3 were downregulated, but miR-224-5p was upregulated in GC tissues and cells, in contrast with their normal counterparts. Mechanistically, LncRNA MIR503HG upregulated TUSC3 in GC cells through sponging miR-224-5p, resulting in the repression of GC progression. Finally, we validated that knock-down of ATF6, but not other two branches of UPR (PERK1 and IRE1), partially rescued cell proliferation and EMT in the GC cells with LncRNA MIR503HG overexpression. Yes Further gain- and loss-of-function experiments validated that the malignant phenotypes in GC cells, including cell proliferation, invasion, epithelial-mesenchymal transition (EMT) and tumorigenesis, were negatively regulated by LncRNA MIR503HG. 34381729 MIR4435-2HG LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Regulation[β-catenin signalling] qRT-PCR//Western Blot//RIP//Transwell Assay Here, we demonstrated that the lncRNA MIR4435-2HG was highly expressed in lung cancer tissues and correlated with histological grades and lymph node metastasis. High expression of lncRNA MIR4435-2HG correlates with lung cancer progression MIR4435-2HG promotes lung cancer cells proliferation and invasion MIR4435-2HG knockdown suppresses the EMT process and cancer stem cell traits MIR4435-2HG knockdown inhibits the β-catenin signalling. Here, we demonstrated that the lncRNA MIR4435-2HG was highly expressed in lung cancer tissues and correlated with histological grades and lymph node metastasis. Yes Phenotypic analysis indicated that MIR4435-2HG knockdown inhibited lung cancer cell proliferation and invasion in vitro and in vivo. 29872866 MIR4435-2HG LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Expression[highly expressed] Flow Cytometry//qRT-PCR//MTT LncRNA MIR4435-2HG is a novel cancer-related lncRNA that was recently found to exhibit high expression in colorectal cancer. The dysregulation of lncRNA miR4435-2HG was significantly related to the tumor size (p<0.001), lymph node metastasis (p<0.001), and tumor node metastasis (TNM) staging (p=0.022). The patients with higher expression of lncRNA miR4435-2HG showed worse prognosis than those with low expression of lncRNA miR4435-2HG group. Yes Besides, the downregulated lncRNA miR4435-2HG expression could repress cell proliferation and enhance cell apoptosis. 32141545 NKILA LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines regulation[NF-κB/Slug] qRT-PCR In this study, we demonstrated that NKILA was down-regulated in HCC tissues and cell lines, and decreased NKILA expression was significantly associated with larger tumor size and positive vascular invasion in HCC patients.Mechanistically, NKILA prevents Slug/epithelial to mesenchymal transition (EMT) pathway via suppressing phosphorylation of IκBα, p65 nuclear translocation and NF-κB activation. In conclusion, these results indicate that NKILA might serve as an effective prognostic biomarker and a promising therapeutic target against HCC metastasis. In this study, we demonstrated that NKILA was down-regulated in HCC tissues and cell lines, and decreased NKILA expression was significantly associated with larger tumor size and positive vascular invasion in HCC patients. Yes Moreover, NKILA inhibits migration and invasion of HCC cells both in vitro and in vivo. 32015685 hsa_circ_0011946 CircRNA Homo sapiens Carcinoma, Adenoid Cystic cancer tissues from patients with SACC Interaction(miR-1205) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results of the present study revealed that the expression levels of hsa_circ_0011946 were significantly upregulated in cancer tissues from patients with SACC. In conclusion, circRNA hsa_circ_0011946 was discovered to promote the malignant process of SACC by downregulating miR-1205 expression. Yes The knockdown of hsa_circ_0011946 expression inhibited the proliferation, invasion and migration of SACC cells, thereby inhibiting the EMT process, which was achieved by downregulating miR-1205 expression. 35317442 MIR503HG LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[wnt1] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay MIR503HG was downregulated in NSCLC. Lon non-coding RNA MIR503HG was downregulated in NSCLC. The over-expression of MIR503HG suppressed cell proliferation and promoted cell apoptosis in vitro and repressed tumorigenesis in vivo. MIR503HG suppressed NSCLC progression via negatively regulating Wnt1 expression. Yes CCK-8 assay and colony formation assay revealed that MIR503HG negatively regulated cell proliferation in NSLCL progression. In addition, MIR503HG promoted cell apoptosis and suppressed cell cycle progression in NSCLC in vitro. MIR503HG inhibited tumor formation in nude mice bearing NSCLC in vivo. 31858550 MIR503HG LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patients regulation[cyclin D1] Flow Cytometry//qRT-PCR//CCK8 MIR503HG was downregulated in NSCLC and low levels of MIR503HG were associated with poor survival. MIR503HG inhibits NSCLC cell proliferation by inducing cell cycle arrest through the downregulation of cyclin D1. MIR503HG was downregulated in NSCLC and low levels of MIR503HG were associated with poor survival. Yes Similarly, MIR503HG overexpression resulted in reduced cell proliferation rate, while overexpression of cyclin D1 caused the increased cell proliferation rate and attenuated effects of MIR503HG overexpression. 32184667 circPGAP3 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues regulation[miR-330-3p/Myc Axis] RNA Pull-Down//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ-PGAP3 expression was significantly increased in TNBC tissues. High circ-PGAP3 was closely associated with large tumor size, lymph node metastasis, later TNM stage and dismal outcome. Yes Through performing a series of in vitro and in vivo experiments, we found that circ-PGAP3 promoted TNBC cell growth and metastasis via sponging and inhibiting miR-330-3p, resulting in the upregulation of proto-oncogene Myc. 33116597 hsa_circ_0027446 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(miR-129-5p/CLDN1 pathway) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//EdU Staining//Transwell Assay Circ_0027446 and CLDN1 expression were significantly upregulated, while miR-129-5p expression was downregulated in PTC tissues and cells. In addition, circ_0027446 acted as a miR-129-5p sponge, and miR-129-5p bound to CLDN1. Moreover, miR-129-5p inhibitors attenuated circ_0027446 depletion-induced effects in PTC cells. CLDN1 also participated in the regulation of miR-129-5p in PTC cell tumor properties. Importantly, circ_0027446 mediated CLDN1 expression by interacting with miR-129-5p. High circ_0027446 expression was closely associated with the poor prognosis of PTC patients. Yes Circ_0027446 depletion inhibited PTC cell proliferation, migration and invasion but increased cell apoptosis. In vivo data showed that the decreased expression of circ_0027446 led to delayed tumor formation. 36058014 hsa_circ_0000644 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC cells and tissues Interaction(miR-1205/E2F3) Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay In PTC, circ_0000644 was highly expressed, and it was located mainly in the cytoplasm, and it had stable structure. Circ_0000644 could directly interact with miR-1205 to repress the expression of miR-1205, and it served as a miR-1205 sponge to modulate E2F3 expression in PTC cells. Circ_0000644 up-regulates E2F3 expression via sponging miR-1205 to promote PTC progression. Yes The knockdown of circ_0000644 repressed PTC cell growth, migration, and invasion, and facilitated apoptosis. 34919034 NKILA LncRNA Homo sapiens Breast Neoplasms MCF-7 breast cancer cells Regulation(expression of HSP90α, NF-κB and β-catenin proteins) qRT-PCR//MTT Results showed, HSP90 and NF-κB/p105, NF-κB/p65 and NF-κB/p50 subunits significantly increased while the level of β-catenin decreased after NKILA inhibition. For the first time we have demonstrated that HSP90 and expression levels of beta-catenin are associated with NKILA levels which may be closely related to the canonical NF-κB pathway in MCF-7 cells. Yes Results showed, HSP90 and NF-κB/p105, NF-κB/p65 and NF-κB/p50 subunits significantly increased while the level of β-catenin decreased after NKILA inhibition. 34125329 MIR503HG LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-489-3p and miR-625-5p] Western Blot//Tunel//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay Results showed that the expression of MIR503HG was significantly upregulated in NSCLC tissues compared with adjacent tissues.In conclusion, knockdown of MIR503HG suppressed proliferation and promoted apoptosis of NSCLC cells through regulating miR-489-3p and miR-625-5p. Yes We found that downregulation of MIR503HG could clearly suppressed cell proliferation and cell cycle progression. Moreover, MIR503HG knockdown also promoted apoptosis of NSCLC cells. As expected, overexpression of MIR503HG significantly promoted cell proliferation and inhibited cell apoptosis in NSCLC NCI-H1975 cells. 31983569 MT1JP LncRNA Homo sapiens Cholangiocarcinoma intrahepatic cholangiocarcinoma specimens Interaction(miR-18a-5p/FBP1 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//IF//Luciferase Report Assay//Transwell Assay MT1JP was downregulated in intrahepatic cholangiocarcinoma specimens, and its expression was related with TNM stage and lymph node metastasis. MT1JP bound to miR-18a-5p to facilitate the expression of fructose-1,6-bisphosphatase 1 (FBP1). MiR-18a-5p was increased in intrahepatic cholangiocarcinoma samples, and its expression was negatively correlated with that of MT1JP. MT1JP was downregulated in intrahepatic cholangiocarcinoma specimens, and its expression was related with TNM stage and lymph node metastasis. Yes Overexpression of MT1JP inhibited proliferation, cell cycle transition, migration and invasion, and induced apoptosis in intrahepatic cholangiocarcinoma cells. The knockdown of MT1JP led to opposite results. In addition, MT1JP also suppressed tumorigenesis in nude mice. 33557774 NKILA LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells regulation[NF-KappaB Signaling Pathway] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay NKILA was poorly expressed in OSCC tissues and cells. This study provided evidence that NKILA could reduce proliferation, invasion and migration of OSCC cells through inhibiting the NF-κB signaling pathway. Yes Cell proliferation, invasion and migration, tumor volume and weight were significantly suppressed in cells with overexpressed NKILA, while silencing NKILA led to opposite trends. 33143574 hsa_circ_0079558 CircRNA Homo sapiens Thyroid Cancer, Papillary papillary thyroid carcinoma (PTC) Interaction(miR-26b-5p/MET/AKT signaling) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay CircRNA_0079558 (circ_0079558) is derived from RAPGEF5 gene, and it has been found to be significantly up-regulated in papillary thyroid carcinoma (PTC). The miR-198/FGFR1 pathway was identified as another signal axis downstream of circ_0079558, and the co-overexpression of FGFR1 and MET largely rescued the proliferation ability of circ_0079558-silenced PTC cells. Yes Through using MET specific inhibitor PHA665752, we found that circ_0079558 overexpression enhanced the malignant behaviors of PTC cells through activating MET/AKT pathway. Through xenograft tumor model, we found that circ_0079558 silencing restrained xenograft tumor growth in vivo. 34565758 MSTRG.81401 LncRNA Rattus norvegicus Diabetic Neuropathic Pain type 2 diabetic rats Regulation(P2X4 ) qRT-PCR//Western Blot After administration with MSTRG.81401 short hairpin RNA (shRNA), the model + MSTRG.81401 shRNA group demonstrated increased mechanical withdrawal threshold, thermal withdrawal latency, open-field test, and sucrose preference test; however, immobility time on the forced swimming test decreased. Thus, lncRNA MSTRG.81401 shRNA can alleviate DNP and MDD-like behaviors in type 2 diabetic rats and may downregulate the expression of P2X4 receptors in the hippocampus and spinal cord of rats. Yes After administration with MSTRG.81401 short hairpin RNA (shRNA), the model + MSTRG.81401 shRNA group demonstrated increased mechanical withdrawal threshold, thermal withdrawal latency, open-field test, and sucrose preference test; however, immobility time on the forced swimming test decreased. MSTRG.81401 shRNA administration significantly decreased the expression of the P2X4 receptor, tumor necrosis factor-α, and interleukin-1β in the hippocampus and spinal cord in the model + MSTRG.81401 shRNA group. Simultaneously, MSTRG.81401 shRNA administration downregulated phosphorylation of ERK1/2 in the hippocampus and spinal cord. 35022948 circPSAP CircRNA Homo sapiens Multiple Myeloma MM tissues and cell line Interaction(miR-331-3p/HDAC4 ) RNA Pull-Down//Immunoblotting//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Bioinformatics Analysis CircPSAP was overexpressed in human MM and high levels of circPSAP predicted poor prognosis in MM patients. Mechanistically, circPSAP functioned as a miR-331-3p sponge, and circPSAP regulated cell proliferation, apoptosis and BTZ sensitivity by sponging miR-331-3p. MiR-331-3p directly targeted and inhibited HDAC4. MiR-331-3p-mediated inhibition of HDAC4 impaired cell proliferation and enhanced cell apoptosis and BTZ sensitivity. Moreover, circPSAP modulated HDAC4 expression by acting as a miR-331-3p sponge. CircPSAP was overexpressed in human MM and high levels of circPSAP predicted poor prognosis in MM patients. Yes CircPSAP depletion repressed cell proliferation and promoted apoptosis and BTZ sensitivity. 35369902 NEAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction[miRNA-22-3p/akt2] Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Invasion Assay The results revealed that NEAT1 expression was associated with tumor size and differentiation where NEAT1 was upregulated in both HCC tissues and cell lines.In conclusion, the results demonstrate that NEAT1 promotes the development of HCC, both in vitro and in vivo, through regulating miRNA-22-3p/AKT2, and provides insight into developing a new strategy for HCC treatment. Yes Overexpression of NEAT1 promoted proliferation and invasion while inhibited apoptosis in HCC cells, which was opposite to the effect of NEAT1 knockdown. 31802908 hsa_circ_0134426 CircRNA Homo sapiens Multiple Myeloma MM bone marrow samples and cell lines Interaction(miR-146b-3p/NDNF network) In Vivo Experiment//Western Blot//Transfection//qPCR//CCK8//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Poor levels of circ_0134426 and NDNF and high levels of miR-146b-3p were observed in MM bone marrow samples and cell lines.circRNA_0134426 decoys miR-146b-3p to repress its expression. Overexpression of miR-146b-3p restored MM cell activities that were blocked by circ_0134426 overexpression. NDNF is a functional molecule targeted by miR-146b-3p, and miR-146b-3p sequesters NDNF expression. The inhibitory effects of NDNF upregulation on MM cell growth, colony formation, and migration were partially abolished by miR-146b-3p overexpression. Circ_0134426 regulates the miR-146b-3p/NDNF network to restrain the development of MM, to some extent, suggesting that the development of MM therapeutic strategies might focus on circ_0134426 regulatory networks. Yes Circ_0134426 overexpression blocked MM cell growth, colony formation, and migration and impeded tumor development in xenograft models. 36460812 NEAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[miR-384 ] Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay Here, we found that NEAT1 is remarkably upregulated in HCC tissues and cell lines. Yes Overexpression of NEAT1 notably accelerated HCC cell proliferation, migration, and invasion. Knockdown of NEAT1 significantly inhibited HCC cell proliferation, migration and invasion. 30346062 NKILA LncRNA Homo sapiens Liver Neoplasms LC tissues and cells Interaction(miR-485-5p) Western Blot//Transfection//CCK8//Flow Cytometry//Transwell Assay The LncRNA NKILA expression was high in LC tissues and cells (P < 0.050), while miR-485-5p was low compared with the normal adjacent tissues (P < 0.050). Online websites predicted that LncRNA NKILA had a binding site with miR-485-5p, and dual-luciferase reporter assay confirmed that LncRNA NKILA could directly target with miR-485-5p (P < 0.050). Prognostic follow-up manifested that high LncRNA NKILA or low miR-485-5p could predict the poor prognosis and high mortality risk of the patients (P < 0.050). Yes LC cells with downregulated LncRNA NKILA documented inhibited proliferation, invasion, and EMT, while the apoptosis level of the cells increased (P < 0.050). The proliferation, invasion, and EMT were inhibited by miR-485-5p increase, while the apoptosis of the cells decreased after upregulating miR-485-5p (P < 0.050). 34512751 hsa_circ_0005615 CircRNA Homo sapiens Multiple Myeloma multiple myeloma tissues and cell lines Interaction(miR-185-5p/IRF4) In Vivo Experiment//Western Blot//Transfection//CCK8//Flow Cytometry//RIP//Luciferase Report Assay//Bioinformatics Analysis Circ_0005615 was upregulated in multiple myeloma tissues and cell lines. Circ_0005615 acted as a molecular sponge for miR-185-5p, and the antitumor effects mediated by circ_0005615 knockdown were reversed by silencing miR-185-5p. IRF4 was confirmed as a direct target of miR-185-5p, and miR-185-5p overexpression-induced antitumor influences could be counteracted by IRF4 overexpression. Circ_0005615 could positively regulate IRF4 expression by sponging miR-185-5p in multiple myeloma cells. Yes Circ_0005615 knockdown restrained the bortezomib resistance and proliferation and induced the apoptosis of multiple myeloma cells. Circ_0005615 knockdown suppressed the growth and bortezomib resistance of xenograft tumors in vivo. 36136989 hsa_circ_0059961 CircRNA Homo sapiens Cholangiocarcinoma CCA tissues and carcinoma cells Interaction(miR-629-5p/SFRP2 axis) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Circ_0059961 expression was decreased in CCA tissues and carcinoma cells. Circ_0059961 was proven to be a target of miR-629-5p, while miR-629-5p was confirmed to be a target of SFRP2. Circ_0059961 targeted miR-629-5p to modulate SFRP2 expression. Upregulation of miR-629-5p reversed the tumor-suppressive effects of circ_0059961 overexpression in rescue trials. Furthermore, SFRP2 overexpression restored miR-629-5p enrichment-promoted cell proliferation, migration, and invasion. Yes Overexpressed circ_0059961 reduced tumor cell proliferation, migration, and invasion while inducing apoptosis.Upregulated circ_0059961 reduced solid tumor growth in vivo. 35490654 circRHOT1 CircRNA Homo sapiens Pancreatic Neoplasms cell lines (PANC-1, Capan-2, Capan-1, SW1990, BxPC-3,AsPC-1) Expression[highly expressed] CCK8//qRT-PCR "Consistently, the expression of circRHOT1 was generally upregulated in pancreatic cancer cells compared with HPDE6c-7 " Yes Reducing the circRHOT1 expression may inhibit the pancreatic cancer cell proliferation, invasion and migration. 30444423 circLDLRAD3 CircRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues and cell lines Regulation[miR-137-3p/PTN axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay The results showed that circ-LDLRAD3 was overexpressed in pancreatic cancer tissues and cell lines.miR-137-3p was identified as a direct target of circ-LDLRAD3. More importantly, upregulation of circ-LDLRAD3 could mitigate the inhibitory effect of miR-137-3p on the proliferation, migration and invasion of pancreatic cancer cells. Besides, circ-LDLRAD3 could regulate the expression of pleiotrophin (PTN) through miR-137-3p. Taken together, knockdown of circ-LDLRAD3 repressed the proliferation, migration and invasion of pancreatic cancer cells through miR-137-3p/PTN axis, providing a new mechanism for pancreatic cancer progression. Yes Knockdown of circ-LDLRAD3 repressed the growth of pancreatic cancer in vitro and in vivo. 31521692 NKILA LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Regulation[NF-κB/Snail signaling pathway] CCK8//qRT-PCR//Transwell Assay//Western Blot The expression level of NKILA in osteosarcoma tissues was significantly lower than that in adjacent tissues, and was related to tumor size, Enneking stage, and metastasis. NKILA knockdown downregulated the expressions of p65 and E-cadherin, but strikingly increased Snail expression. The RNA binding protein co-immunoprecipitation experiments illustrated that p65 could bind to NKILA. Additionally, JSH was found to reverse the inhibitory effect of NKILA on cell migration and proliferation. The expression level of NKILA in osteosarcoma tissues was significantly lower than that in adjacent tissues, and was related to tumor size, Enneking stage, and metastasis. Yes After KNKS/NP cells were transfected with NKILA-siRNA, cell proliferation, invasion and migration were enhanced. Transfection of the NKILA overexpression plasmid in Saos2 cells reduced cell proliferation, invasion and migration. 31173281 NKILA LncRNA Homo sapiens Retinoblastoma blood Interaction[lncRNA XIST] CCK8//qRT-PCR We found that, comparing to healthy controls, NKILA was downregulated, while lncRNA XIST was upregulated in plasma of retinoblastoma patients and they were inversely correlated. Downregulation of NKILA distinguished early-stage patients from healthy controls. Overexpression of lncRNA NKILA mediated the downregulation of XIST in retinoblastoma cells, while XIST overexpression failed to significantly affect NKILA. Yes Overexpression of NKILA resulted in decreased, while XIST overexpression resulted in increased proliferation, migration and invasion rates of retinoblastoma cells. 30995132 circAMOTL1L CircRNA Homo sapiens Pancreatic Neoplasms PCa tissues,cell lines Regulation[circAMOTL1L-miR-193a-5p-Pcdha regulatory axis ] Northern Blot//ISH//qRT-PCR//RIP//Luciferase Report Assay//IF Here we show that a Amotl1-derived circRNA, termed circAMOTL1L, is downregulated in human Pca. These findings have linked p53/RBM25-mediated circAMOTL1L-miR-193a-5p-Pcdha regulatory axis to EMT in metastatic progression of PCa. Yes Here we show that a Amotl1-derived circRNA, termed circAMOTL1L, is downregulated in human PCa, and that decreased circAMOTL1L facilitates PCa cell migration and invasion through downregulating E-cadherin and upregulating vimentin, thus leading to EMT and PCa progression. 30531834 MIR600HG LncRNA Mus musculus Alzheimer Disease AD transgenic mouse models Regulation(PINK1 ) qRT-PCR//Immunoblotting//RNA Pull-Down MIR600HG expression was elevated during aging in two different types of AD transgenic mouse models. Next, we found that increased MIR600HG directly interact with NEDD4L, which promoted PINK1 ubiquitination and degradation, and as well as autophagy activation. Additionally, MIR600HG promoted Aβ production and suppressed Cytochrome C Oxidase activity. Administration of AAV-shMIR600HG restored the Cytochrome C Oxidase activity and inhibited Aβ production. Furthermore, PINK1 overexpression or MIR600HG knockdown significantly ameliorated the cognitive impairment in APP/PS1 mice. PINK1 depletion recovered the spatial memory defect in the AAV-shMIR600HG injected APP/PS1 mice. Yes Next, we found that increased MIR600HG directly interact with NEDD4L, which promoted PINK1 ubiquitination and degradation, and as well as autophagy activation. Additionally, MIR600HG promoted Aβ production and suppressed Cytochrome C Oxidase activity. Administration of AAV-shMIR600HG restored the Cytochrome C Oxidase activity and inhibited Aβ production. 34958029 NKILA LncRNA Homo sapiens Rectal Neoplasms rectal cancer tissues and cells Expression[lower expressed] qRT-PCR The results suggested NKILA expression was decreased in rectal cancer tissues and cells, and correlated with clinical stage, T classification, N classification and M classification. The results suggested NKILA expression was decreased in rectal cancer tissues and cells, and correlated with clinical stage, T classification, N classification and M classification.NKILA low-expression was an independent poor prognostic factor in rectal cancer patients. Yes NKILA-inhibited rectal cancer cell proliferation, migration, and invasion via suppressing NF-κB signaling. 30171719 MIR5HG LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues Interaction[downregulation of miR-204-5p] qRT-PCR//Transfection In the present study we found that MIR100HG was upregulated, while miR-204-5p was downregulated in tumor tissues than in adjacent healthy tissues of laryngeal squamous cell carcinoma (LSCC) patients. A significant and inverse correlation between MIR100HG and miR-204-5p was found in tumor tissues but not in adjacent healthy tissues of LSCC patients. Overexpression of MIR100HG resulted in the downregulation of miR-204-5p in LSCC cells, while miR-204-5p overexpression failed to significantly affect MIR100HG expression. In addition, miR-204-5p overexpression attenuated the enhancing effects of MIR100HG overexpression on cancer cell proliferation, migration and invasion. Expression of MIR100HG was significantly affected by AJCC stage. Yes Overexpression of MIR100HG led to promoted, while miR-204-5p, overexpression led to inhibited proliferation, migration and invasion of LSCC cells. 31114240 NKILA LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cells Interaction(miR-582-3p-YAP1 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay Here, our study demonstrated that NKILA was significantly upregulated in CCA tissues and cells. The 5-methylcytosine (m5 C) methyltransferase NSUN2 interacts with NKILA, increasing its m5 C level and promoting its interaction with YBX1. Moreover, NKILA physically interacted with and suppressed miR-582-3p, which was regulated by METTL3-mediated N6 -methyladenosine (m6 A) modification. Finally, we showed that YAP1 was a target of NKILA via miR-582-3p and NKILA functioned partially via YAP1 in CCA. Overexpression of NKILA is associated with advanced TNM stage, lymph node and distant metastasis, and also indicated poor prognosis in CCA patients. Yes Functionally, NKILA facilitated CCA growth and metastasis in vitro and in vivo. 35274813 NKILA LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Interaction[NF-κB pathway] ISH//qRT-PCR//Luciferase Report Assay//IF Compared with control tissues, NKILA expression was identified to be decreased in NPC tissues. Low NKILA expression was correlated with unfavorable clinicopathological features and predicted poor survival outcome in NPC patients. Yes Furthermore, we found that NKILA overexpression in high-metastatic-potential NPC cells repressed motile behavior and impaired the metastatic capacity in vitro and in vivo. 31430288 NKILA LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and CC cell lines (SiHa, C-33A, CaSki and HeLa) regulation[NF-κB activation] CCK8//qRT-PCR//Wound Healing Assay//Western Blot The expression levels of NKILA were decreased in CC tissues and CC cell lines (SiHa, C-33A, CaSki and HeLa) and the downregulation of NKILA expression using shRNA was observed to significantly increase the proliferation of CC cells. In conclusion, the results from the present study suggested that NKILA may be involved in the inhibition of migration and invasion in CC cells through regulating EMT processes, which may be related to its inhibition of NF-κB activation. Yes Conversely, the upregulation of NKILA inhibited the proliferation of CC cells, in addition to significantly inhibiting the migration and invasion of CaSki cells, whereas the knockdown of NKILA promoted the invasion of C-33A cells. 32765657 NKILA LncRNA Homo sapiens Breast Neoplasms Regulation[NF-κB/IL-6 signaling pathway] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT Cell viability and migration of MDA-MB-231 cells were significantly inhibited, while cell apoptosis was obviously promoted by overexpression of NKILA. Overexpression of NKILA could also inhibit the phosphorylation of IκBα and the nuclear transposition of p65, as well as induce cell apoptosis-related proteins and inhibit epithelial-mesenchymal transition-related proteins. Cell viability and migration of HUVEC were also significantly inhibited when treated with supernatant of cells overexpressed NKILA or treated with BAY11-7028. Exogenous IL-6 significantly increased the cell viability and migration of HUVEC, and overexpression of NKILA could reverse these effects induced by IL-6. Overexpression of NKILA significantly inhibited the protein levels of IL-6 and VEGFA in supernatant, as well as VEGFR in HUVEC, thus inhibited the angiogenesis of HUVEC. NKILA also reversed the above effects on protein levels of IL-6 and VEGFA in supernatant and angiogenesis induced by exogenous IL-6. Yes Cell viability and migration of HUVEC were also significantly inhibited when treated with supernatant of cells overexpressed NKILA or treated with BAY11-7028. 31862380 MIR4435-2HG LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-125b-5p/Sema4D ) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay LncRNA MIR4435-2HG and Sema4D were highly expressed, while miR-125b-5p expression was decreased in CRC tissues and cells. Knockdown of MIR4435-2HG/Sema4D or overexpression of miR-125b-5p inhibited CRC cell proliferation and aggressiveness; overexpression of MIR4435-2HG/Sema4D or knockdown of miR-125b-5p prompted the malignant behaviors of cancer cells.MIR4435-2HG and Sema4D competitively bound to miR-125b-5p. Yes Knockdown of MIR4435-2HG/Sema4D or overexpression of miR-125b-5p inhibited CRC cell proliferation and aggressiveness; overexpression of MIR4435-2HG/Sema4D or knockdown of miR-125b-5p prompted the malignant behaviors of cancer cells. 35730423 NKX2-1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC cell lines and tumor tissues Interaction(miR-145-5p/SERPINE1/VEGFR-2) In Vivo Experiment//Western Blot//Tube Formation Assay//Migration Assay//CCK8//qRT-PCR//Colony Formation Assay//FISH//RIP//Luciferase Report Assay//Cell Cycle Assay//IHC//Invasion Assay The results indicated that NKX2-1-AS1 expression was upregulated in GC cell lines and tumor tissues. RIP and dual-luciferase assays revealed that the microRNA miR-145-5p is a direct target of NKX2-1-AS1 and that NKX2-1-AS1 serves as a ceRNA to sponge miRNA and regulate angiogenesis in GC. Moreover, serpin family E member 1 (SERPINE1) is an explicit target for miR-145-5p; besides, the NKX2-1-AS1/miR-145-5p axis induces the translation of SERPINE1, thus activating the VEGFR-2 signaling pathway to promote tumor progression and angiogenesis. Yes Overexpression of NKX2-1-AS1 was significantly associated with tumor progression and enhanced angiogenesis. Functionally, NKX2-1-AS1 overexpression promoted GC cell proliferation, metastasis, invasion, and angiogenesis, while NKX2-1-AS1 knockdown restored these effects, both in vitro and in vivo. 33512745 MIR4435-2HG LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cell lines regulation[ miR-513a-5p/KLF6 axis] Western Blot//ISH//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this study, we found the up-regulation of MIR4435-2HG in ccRCC tissues and cell lines.Then, bioinformatic analysis and luciferase reporter assays confirmed the negative regulation effect of MIR4435-2HG on miR-513a-5p. And further investigations showed that KLF6, which collected from the intersection of databases, was the potential conjugated mRNAs of miR-513a-5p. Yes Functionally, overexpression of MIR4435-2HG promoted the proliferation as well as the metastasis in ccRCC cell lines, whereas knockdown of MIR4435-2HG inhibited the above changes. 33460239 MIR4435-2HG LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells regulation[miR-128-3p/CKD14 axis] RNA Pull-Down//Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay MIR4435-2HG and CDK14 were over-expressed in OC tissues and cells. MIR4435-2HG knockdown inhibited proliferation, invasion and migration but induced apoptosis of OC cells via miR-128-3p/CDK14 axis. Patients with high MIR4435-2HG expression had poorer overall survival (OS) than patients with low MIR4435-2HG expression. Yes MIR4435-2HG knockdown inhibited proliferation, invasion and migration but induced apoptosis of OC cells via miR-128-3p/CDK14 axis. 32377170 MIR4435-2HG LncRNA Homo sapiens Urinary Bladder Neoplasms Bca tissues and cells Interaction(microRNA-2467-3p/IQGAP3) qRT-PCR//RIP MIR4435-2HG was highly expressed in BCa. In terms of underlying mechanism, MIR44352HG acted as a microRNA-2467-3p (miR-2467-3p) sponge to control the expression of IQ motif containing GTPase activating protein 3 (IQGAP3) and cell division cycle associated 5 (CDCA5), resulting in activation of the rat sarcoma virus (Ras)/rapidly accelerated fibrosarcoma (Raf)/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) and PI3K/AKT/mTOR signaling pathways. Yes oreover, MIR4435-2HG silencing abrogated BCa cell proliferation, migration, and invasion. 35993042 circKIF4A CircRNA Homo sapiens Thyroid Cancer, Papillary papillary thyroid cancer tissues and cell lines Interaction(miR-1231 /GPX4) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay In the current study, we explored circKIF4A and the result showed that it had high expression in papillary thyroid cancer. Our consequence showed circKIF4A facilitated the malignant progress of papillary thyroid tumor by sponging miR-1231 and upregulating GPX4 expression. Yes Knockdown of circKIF4A could suppress papillary thyroid cell growth and migration. 34153004 MIR4435-2HG LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues regulation[miR-128-3p/MSI2 Axis] Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay LncRNA MIR4435-2HG expression was significantly up-regulated in CC tissues (P < 0.001) and cells (P < 0.01). MIR4435-2HG knockdown suppresses the proliferation, migration and invasion of CC cells through regulating the miR-128-3p/MSI2 axis, providing a possible therapeutic strategy for CC. Yes Knockdown of MIR4435-2HG inhibited the proliferation, migration and invasion of CC cells (P < 0.01). 33061572 MIR4435-2HG LncRNA Homo sapiens Glioblastoma GBM tissues and cell lines regulation[miR-1224-5p/TGFBR2 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//cell invasion assay//Colony Formation Assay Further experimental assays verified the up-regulation of MIR4435-2HG in GBM tissues and cell lines.Taken together, the present study suggests the oncogenic role of MIR4435-2HG in GBM and underlies the key function of MIR4435-2HG-driven GBM progression via targeting miR-1224-5p/TGFBR2 axis. Yes In vitro cell studies and in vivo animal studies showed that knockdown of MIR4435-2HG resulted in the inhibition of GBM cell proliferation and invasion and in vivo tumour growth, while MIR4435-2HG overexpression driven GBM progression. 32319715 NNT-AS1 LncRNA Homo sapiens lung squamous cell carcinoma LUSC tissues and cell lines regulation[miR-22/FOXM1 axis] Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay NNT-AS1 and FOXM1 were up-regulated but miR-22 was down-regulated in LUSC tissues and cell lines. LncRNA NNT-AS1 contributes to cell carcinogenesis in LUSC by regulating the miR-22/FOXM1 axis, providing a novel insight into the pathogenesis of LUSC and a new potential therapeutic target for LUSC treatment. Yes NNT-AS1 was a sponge of miR-22, and NNT-AS1 deletion suppressed the migration and invasion but induced apoptosis in LUSC cells. 32514270 NNT-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC specimens Interaction(miR-137/ Y-box binding protein 1 axis) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay The results showed that NNT-AS1 was significantly upregulated in ccRCC specimens compared with normal tissues. Mechanistically, NNT-AS1 acted as a competitive endogenous RNA to sponge miR-137, which depressed ccRCC cells proliferation and metastasis. Moreover, with the use of bioinformatics analysis, the famous oncogene YBX-1 was selected as the potential target of miR-137. Luciferase assay also confirmed the interaction between miR-137 and YBX-1. Yes Inhibition of NNT-AS1 restrained ccRCC proliferation and metastasis. 34643163 circWDR27 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(miR-215-5p/TRIM44 Axis) Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay CircWDR27 and TRIM44 were highly expressed while miR-215-5p was lowly expressed in PTC tissues and cells. Moreover, miR-215-5p was a direct target of circWDR27, and its inhibition reversed the suppressive effect of circWDR27 knockdown on PTC cell progression. In addition, miR-215-5p directly targeted TRIM44, and miR-215-5p exerted its anti-cancer role in PTC cells by targeting TRIM44. Yes Knockdown of circWDR27 suppressed cell proliferation and metastasis and induced cell cycle arrest and apoptosis in PTC cells. 34040392 MIR4435-2HG LncRNA Homo sapiens Carcinoma, Renal Cell Expression[highly expressed] qRT-PCR//RNA Pull-Down The microarray analysis identified an upregulated lncRNA MIR4435-1HG in renal carcinoma. The expression level of MIR4435-1HG was correlated with TNM stage, tumor size, and Fuhrman grade. High expression of MIR4435-1HG indicated poor prognosis. Yes MIR4435-1HG knockdown inhibited cell proliferation, and suppressed the migrating and invasive capacity of renal carcinoma cells. 32538823 NKX3-1 LncRNA Homo sapiens Glioma glioma tumor tissues Regulation(Fem1b/SPDEF pathway) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//Bioinformatics Analysis//Transwell Assay NKX3-1 lncRNA was found to be significantly increased in glioma tumor tissues. LncRNA NKX3-1 significantly increased the luciferase activity of Fem1b 3'-UTR-WT reporter genes (P <0.05) as well as the levels of SPDEF protein (P <0.05). The protein level of FEM1B was significantly reduced. Cell invasion and migration were significantly increased (P <0.05) in the lncRNA NKX3-1 overexpression group plus SPDEF group. Yes Proliferation, invasion, and migration of glioma cells were significantly increased (P <0.05) in the lncRNA NKX3-1 overexpression group, while apoptosis ability was significantly decreased (P <0.05).Tumor volume and weight were significantly increased in the lncRNA NKX3-1 overexpression group in nude mice (P <0.05). 34350121 MIR4435-2HG LncRNA Homo sapiens prostate carcinoma blood Regulation[upregulating TGF-β1 ] qRT-PCR//ELISA//Western Blot//Transwell Assay The present study demonstrated that plasma levels of MIR4435-2HG and transforming growth factor-β1 (TGF-β1) were significantly higher in patients with PCa compared with healthy controls.These results suggested that MIR4435-2HG may promote PCa by upregulating TGF-β1. The results from the follow-up study suggested that MIR4435-2HG was closely associated with patient survival. Yes MIR4435-2HG overexpression and treatment with TGF-β1 promoted cancer cell invasion and migration. In addition, TGF-β inhibitor attenuated the enhancing effects of MIR4435-2HG overexpression on cell invasion and migration. MIR4435-2HG overexpression led to upregulation of TGF-β1 expression, whereas TGF-β1 treatment had no effect on MIR4435-2HG expression. 31516603 MIR4435-2HG LncRNA Homo sapiens stomach carcinoma clinical gastric carcinoma tissues and cells. Interaction(MiR-138-5p/Sox4 Axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay The bioinformatics analysis based on TCGA and GEO databases indicated that MIR4435-2HG was obviously elevated in gastric carcinoma samples. The qRT-PCR analysis revealed that MIR4435-2HG was upregulated in clinical gastric carcinoma tissues and cells. Mechanically, we identified that MIR4435-2HG enhanced Sox4 expression by directly interacting with miR-138-5p as a competitive endogenous RNA (ceRNA) in gastric carcinoma cells, in which Sox4 was targeted by miR-138-5p. The high expression of MIR4435-2HG is associated with the poor survival rate of patients. Yes The knockout of MIR4435-2HG could repress the proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) and accelerate the apoptosis of gastric carcinoma cells. Moreover, the deletion of MIR4435-2HG was able to attenuate the tumor growth in vivo. 34532282 NNT-AS1 LncRNA Homo sapiens Prostatic Neoplasms PCa cells regulation[miR-496/DDIT4 axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down NNT-AS1 was apparently upregulated in PCa cells.NNT-AS1 contributes to the malignant phenotypes of PCa cells through targeting miR-496 to boost DDIT4 expression. Yes NNT-AS1 deficiency abrogated PCa cell viability, proliferation and migration but promoted apoptosis. 32982585 NNT-AS1 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cell lines regulation[down-regulating miR-203] BrdU//qRT-PCR//Flow Cytometry//Western Blot NNT-AS1 overexpression was appeared in CCA tissues and cell lines.NNT-AS1 promoted proliferation, EMT and PI3K/AKT and ERK1/2 pathways in CCLP1 and TFK1 cells through down-regulating miR-203. Yes Proliferation was promoted by NNT-AS1 overexpression in CCLP1 and TFK1 cells. 32019904 MIR4435-2HG LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues Regulation[MIR4435-2HG/TGF-β1 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay Here, it was identified that lncRNA MIR4435-2HG was highly expressed in lung cancer tissues, especially in nonsmall cell lung cancer (NSCLC).Transcriptome-sequencing analysis indicated that TGF-β signaling was mostly enriched in NSCLC cells with MIR4435-2HG knockExpression[down-expression]. Furthermore, MIR4435-2HG was identified as an miRNA sponge for TGF-β1 and thus activated TGF-β signaling. Additionally, re-activation of TGF-β1 rescued MIR4435-2HG knockExpression[down-expression]-mediated inhibition on the progression of NSCLC cells. Yes Functional experiments showed that knockExpression[down-expression] of MIR4435-2HG reduced the proliferation and migration ability of NSCLC cells. 31875359 MIR4435-2HG LncRNA Homo sapiens Glioma human glioma cell lines Interaction(miR-125a-5p/TAZ) Western Blot//Transfection//Colony Formation Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Transwell Assay We found that miR-125a-5p was closely related to the TAZ gene, and the lncRNA MIR4435-2HG was closely related to miR-125a-5p. Besides, it also increased the tumor volume of gliomas in a rat model subcutaneously inoculated with glioma cells. We also found miR-125a-5p could block the effect of MIR4435-2HG-OE and TAZ. Yes Both MIR4435-2HG-OE and TAZ increased the expression of the TAZ gene, activated the Wnt signaling pathway, inhibited apoptosis, and promoted migration and proliferation in glioma cells. 34714963 circPUM1 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissue samples and cells Interaction(miR-21-5p/MAPK1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Significantly, circPUM1 was upregulated in PTC tissue samples and cells . Besides, circPUM1 could sponge miR-21-5p and MAPK1 was a target gene of miR-21-5p. Yes Cell growth, metastasis and glycolytic process of PTC cells were all inhibited after downregulation of circPUM1. 33481227 circPSD3 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines Interaction(miR-7-5p/METTL7B axis) Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay In this study, qRT-PCR results showed that circ-PSD3 was significantly upregulated in PTC tissues and cell lines.Besides, circ-PSD3 interacted with miR-7-5p to reduce its expression, and methyltransferase like 7B (METTL7B) was verified as a target gene of miR-7-5p. Functionally, inhibition of circ-PSD3 impeded PTC cell proliferation and invasion via targeting miR-7-5p to downregulate METTL7B expression. Meanwhile, circ-PSD3 overexpression was positively associated with larger tumor size, TNM stage, and lymph node metastasis. Yes Knockdown of circ-PSD3 suppressed the proliferation and invasion of PTC cells. 33858297 NEAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular SMMC-7721 and Huh7 cells Interaction(miR-214) qRT-PCR NEAT1 expression level was significantly elevated in SMMC-7721 and Huh7 cells. NEAT1 serves as a sponge for miR-214. Besides, PSMB8 was a direct target of miR-214. Furthermore, ALKBH5 could up-regulate NEAT1 expression by inhibiting m6A enrichment. Yes Knockdown of NEAT1 inhibited proliferation and migration, induced apoptosis of HCC cell lines. 35357550 MIR4435-2HG LncRNA Homo sapiens Carcinoma, Hepatocellular Hepatic stellate cell Interaction(MIR4435-2HG/miR-506-3p/TGFB1 axis) qRT-PCR//Wound Healing Assay//Transwell Assay In conclusion, HSC-released CXCL1 aggravated HCC cell malignant behaviors through the MIR4435-2HG/miR-506-3p/TGFB1 axis. Yes In an orthotopic xenotransplanted tumor model of HCC cells plus HSCs in mice, CXCR2 knockdown in HCC cells significantly inhibited tumorigenesis, which was partially reversed by MIR4435-2HG overexpression in HCC cells. 36169092 circRAD18 CircRNA Homo sapiens Thyroid Cancer, Papillary papillary thyroid tissues and cell lines Interaction(miR-516b-PDK1 axis) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We characterized circRAD18 as a significantly upregulated circRNA in papillary thyroid tissues and cell lines and found its downregulation could inhibit the growth and metastasis ability of papillary thyroid cancer. Inhibition of circRAD18 could decrease the expression level of PDK1 protein by sponging miR-516b. Yes We characterized circRAD18 as a significantly upregulated circRNA in papillary thyroid tissues and cell lines and found its downregulation could inhibit the growth and metastasis ability of papillary thyroid cancer. Interestingly, we found that circRAD18 was involved in glucose metabolism reprogramming of papillary thyroid cancer, and its silence could remarkably inhibit cell glucose uptake and lactate production in papillary thyroid cancer cells. 34527562 NLIPMT LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[GSK3β ] qRT-PCR Here, we reported that RP11-115N4.1 (here renamed novel lncRNA inhibiting proliferation and metastasis [NLIPMT]) was downregulated in breast cancer tissues. Mechanistically, glycogen synthase kinase 3β (GSK3β) was identified as an effector protein regulated by lnc-NLIPMT. Inhibition of GSK3β activity restored NLIPMT-induced inhibition of proliferation and motility in breast cancer cells. Yes Ectopic expression of NLIPMT inhibited mammary cell proliferation, motility in vitro. Moreover, lnc-NLIPMT reduced the growth of implanted MDA-MB-231 cells in vivo 30417392 MIR4435-2HG LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tumor tissue and neutrophils Expression(highly expressed) CCK8//qRT-PCR//Migration Assay RNAscope assays showed that most MIR4435-2HG was located in the tumor stroma, which caused high expression of MIR4435-2HG in colorectal cancer tumor tissue. Mechanistically, Mir4435-2hg depletion enhanced the immunosuppressive ability of PMN-MDSCs by disturbing their fatty acid metabolism. Yes Transcriptome analysis of colorectal cancer tissues from wild-type and Mir4435-2hg-deficient mice revealed Mir4435-2hg as a tumor suppressor gene that regulated the immune microenvironment. Loss of Mir4435-2hg led to a decline in neutrophils and elevation of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC). In tissue-specific Mir4435-2hg knockout mice, we confirmed that Mir4435-2hg depletion in neutrophils, but not in intestinal epithelial cells, promoted colorectal cancer progression. 35862232 MIR4435-2HG LncRNA Homo sapiens Colonic Neoplasms colorectal cancer cells and tissues Expression(highly expressed) qRT-PCR//Wound Healing Assay//Western Blot MIR4435 expression correlated with the size of intestinal polyps in children. Expression of MIR4435 was up-regulated in colorectal cancer. Smad4 and desmoplakin were up-regulated and β-catenin was down-regulated in HCT116 cells by MIR4435 knockdown. Yes MIR4435 knockdown in HCT116 cells inhibited their proliferation, adhesion, and invasion ability. 36191994 hsa_circ_0011058 CircRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(miR-335-5p/YAP1 ) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Bioinformatics Analysis//Transfection//Tube Formation Assay//qPCR//CCK8//Flow Cytometry//RIP//Luciferase Report Assay//H&E Staining//Colony Formation Assay//EdU Staining Circ_0011058 expression was aberrantly elevated in PTC tissues and cells.Circ_0011058 promoted PTC cell proliferation, angiogenesis and radioresistance by upregulating YAP1 via acting as miR-335-5p sponge. Yes The downregulation of circ_0011058 suppressed proliferation, angiogenesis and radioresistance in PTC cells. 34562605 MIR503HG LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell Regulation(NF-κB/NLRP3 pathway) qRT-PCR//Western Blot Interestingly, we observed that the expression of lncRNA MIR503HG was downregulated after NETs stimulation, and ectopic MIR503HG expression reversed the metastasis-promoting effect of NETs in vitro and in vivo. Together, these results show that NETs activate the NF-κB/NLRP3 pathway by downregulating MIR503HG expression to promote EMT and NSCLC metastasis. Yes Interestingly, we observed that the expression of lncRNA MIR503HG was downregulated after NETs stimulation, and ectopic MIR503HG expression reversed the metastasis-promoting effect of NETs in vitro and in vivo. 35707534 MIR503HG LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(hsa-miR-503-3p and hsa-miR-503-5p) CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay Both GEO and TCGA+ GTEx databases showed that the expression of MIR503HG in ESCC tissues was higher than that in adjacent tissues and normal esophageal tissues (P<0.01). After knockdown of MIR503HG, the relative expression levels of hsa-miR-503-3p in KYSE30 cells of shMIR503HG1 group and shMIR503HG2 group were 0.66±0.02 and 0.58±0.00, respectively, the relative expression levels of hsa-miR-503-5p were 0.64±0.00 and 0.68±0.03, respectively, which were all lower than those in shNC group (P<0.01). After knockdown of MIR503HG, overexpression of hsa-miR-503-3p and hsa-miR-503-5p attenuated the inhibitory effects of knockdown of MIR503HG on proliferation (P<0.001), invasion (P<0.01) and migration (P<0.001) of KYSE30 cells. Yes Compared with shNC group, the proliferation rates of KYSE30 and KYSE510 cells after knockdown of MIR503HGwere significantly inhibited (P<0.001). The colony formation numbers of KYSE30 cells in shMIR503HG1 group and shMIR503HG2 group were (2.00±1.41) and (1.33±0.47), respectively, significantly lower than that of the shNC group (P=0.002). The clone formation numbers of KYSE510 cells in shMIR503HG1 group and shMIR503HG2 group were (174.67±15.97) and (80.33±6.34), respectively, significantly lower than that of the shNC group (P<0.001). The invasive numbers of KYSE30 cells in shMIR503HG1 group and shMIR503HG2 group were 75.33±6.02 and 45.67±7.59, significantly lower than that of the shNC group(P<0.001). The migrating number of KYSE30 cells in shMIR503HG1 group and shMIR503HG2 group were 244.00±10.23 and 210.67±13.52, significantly lower than that of the shNC group(P<0.001), and the cell cycle was arrested in G(0)/G(1) phase. The xenograft experiment showed that the subcutaneous tumor in shMIR503HG group was significantly smaller than that in shNC group, and the tumor weight in shMIR503HG group was (0.097±0.026) g, which was lower than (0.166±0.021) g in shNC group (P<0.001). 36380664 circZEB1 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tumor tissues and tumor cell lines interaction[sponging miR-448] CCK8//qRT-PCR//RNA Pull-Down//Tunel Compared with normal tissues and breast epithelial cells, the expression of circ-ZEB1 was markedly higher in TNBC tumor tissues and tumor cell lines. In conclusion, our findings identified a new functional circ-ZEB1 in TNBC tumorigenesis, and revealed the important regulatory role of circ-ZEB1 via sponging miR-448, providing a novel insight for TNBC pathogenesis. Yes The small hairpin RNA-mediated circ-ZEB1 knockdown inhibited TNBC cell proliferation and induced cell apoptosis. 32629026 MIR4435-2HG LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue,cell lines Expression[Expression[highly expressed]-expression] CCK8//qRT-PCR We showed that the lncRNA AK001796 expression was significantly Expression[up-expression]-regulated in HCC tissues and cell lines, compared to their controls, respectively. Higher lncRNA AK001796 expression closely correlated with tumor size (p<0.05), TNM stage (p<0.05) and the poor overall survival (OS) rate of HCC patients (p<0.05). Besides, multivariate Cox regression analysis found that lncRNA AK001796 expression was identified as an independent risk factor for HCC prognosis. Yes LINC01288 significantly promotes viability, migration, xenograft tumor growth and metastasis in vitro and in vivo. 30915744 NLIPMT LncRNA Homo sapiens Esophageal Neoplasms ESCC tissues regulation[miR-320/Survivin Axis] Western Blot//Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay//Transwell Assay NLIPMT was downregulated in ESCC and predicted poor survival of ESCC patients.We demonstrate that NLIPMT inhibits cell proliferation and migration and promotes cell cycle arrest and apoptosis in ESCC cells by regulating the miR-320/survivin axis. NLIPMT was downregulated in ESCC and predicted poor survival of ESCC patients. Yes Moreover, both NLIPMT and miR-320 overexpression inhibited cell proliferation and migration and promoted cell cycle arrest and apoptosis in ESCC cells, while their effects were abolished by survivin overexpression. 33324105 NLIPMT LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissue samples and cell lines Expression[lower expressed] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Our results revealed a downregulation of the expression of lnc-NLIPMT in PTC and a negative correlation between lnc-NLIPMT expression and tumor size (P=0.006). Our results revealed a downregulation of the expression of lnc-NLIPMT in PTC and a negative correlation between lnc-NLIPMT expression and tumor size (P=0.006). Yes Overexpression of lnc-NLIPMT in TPC-1 and B-CPAP cells significantly suppressed cell proliferation, migration, and invasion, while lnc-NLIPMT knockdown had the opposite effect. 33116886 MIR4435-2HG LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[upregulating miRNA-487a] CCK8//qRT-PCR We found that MIR4435-2HG and miRNA-487a were upregulated in tumor tissues compared to adjacent healthy tissues from HCC patients.Correlation analysis showed that MIR4435-2HG and miRNA-487a were positively correlated in both the tumor tissues and adjacent healthy tissues from HCC patients. Yes Overexpression of MIR4435-2HG led to upregulation of miRNA-487a in the cells of HCC cell lines, while overexpression of miRNA-487a did not significantly affect MIR4435-2HG. Overexpression of MIR4435-2HG and miRNA-487a promoted the proliferation of cells of HCC cell lines, and miRNA-487a knockdown partially attenuated the enhancing effects of MIR4435-2HG overexpression on cancer cell proliferation. 30988676 MIR503HG LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Interaction[TGF-β2] qRT-PCR//Western Blot We found that MIR503HG was Expression[down-expression]regulated and TGF-β2 was Expression[Expression[up-expression]-expression]regulated in CRC included in this study. MIR503HG and TGF-β2 were inversely correlated in CRC tissues, and in CRC cells, MIR503HG overexpression was accompanied by TGF-β2 Expression[down-expression]regulation, while TGF-β2 overexpression did not affect MIR503HG. Low levels of MIR503HG were associated with poor survival of CRC patients within 5 years after admission. Yes MIR503HG overexpression mediated the decreased migration and invasion rates of CRC cells. 31278965 NEAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines regulation[NEAT1/miR-320a/LAGE3 axis] qRT-PCR The present study found that NEAT1 was significantly overexpressed in HCC cell lines compared with LX?2 hepatic stellate cells. In conclusion, the present findings revealed that the NEAT1/miR‑320a/LAGE3 axis participates in HCC development and that NEAT1 could be used as a biomarker for HCC. Yes Knockdown of NEAT1 significantly repressed HCC cell viability, increased cell apoptosis, and inhibited cell migration and invasion capacity. By contrast, upregulation of NEAT1 demonstrated the reverse effects. 32945386 NEAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[HIF-1α ] Western Blot//Wound Healing Assay//Co-IP//CCK8//qRT-PCR//Transwell Assay NEAT1 and HIF-1α were highly expressed and showed a positive relationship in HCC tissues, and specifically, higher NEAT1 expression was positively associated with advanced TNM stage and metastasis in HCC patients.HIF-1α knockdown inhibits NEAT1 expression, which suppresses progression of HCC and improves its prognosis. NEAT1 and HIF-1α were highly expressed and showed a positive relationship in HCC tissues, and specifically, higher NEAT1 expression was positively associated with advanced TNM stage and metastasis in HCC patients. Yes NEAT1 overexpression further promoted development of HCC under hypoxia while promoting cell viability, migration and invasion and suppressing apoptosis, and such effects were reversed by down-regulating HIF-1α. NEAT1 overexpression promoted tumor growth, which was reversed by down-regulating HIF-1α. 32774741 circUBAP2 CircRNA Homo sapiens Thyroid Cancer, Papillary TC tissues and cells Interaction(miR-370-3p) RNA Pull-Down//Bioinformatics Analysis//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay CircUBAP2 was upregulated and miR-370-3p was downregulated in TC tissues and cells. Bioinformatics analysis showed that circUBAP2 contained putative binding sites of miR-370-3p. CircUBAP2 acted as a sponge to inhibit miR-370-3p expression. Mechanistically, miR-370-3p inhibition abolished the effects of circUBAP2 on proliferation, apoptosis, and invasion in TC cells. Yes CircUBAP2 was highly stable, resistant to RNase R digestion, and predominantly localized in the cytoplasm. CircUBAP2 knockdown inhibited cell proliferation and invasion and triggered apoptosis in TC cells. 34346032 NEAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR//MTT//Western Blot//Transwell Assay LncRNA NEAT1 expression was significantly increased in HCC tissues compared with adjacent tissues (p < 0.05). Yes Compared with the siRNA group, transfection of lncRNA NEAT1 siRNA into HepG2 cells significantly inhibited cell proliferation, increased Caspase 3 activity and apoptosis, reduced cell invasion, as well as arrested cell cycle (p < 0.05). 32373951 NLIPMT LncRNA Homo sapiens Colorectal Neoplasms CRC tissue regulation[Downregulating TGF-β1] qRT-PCR//Transwell Assay We found that NLIPMT was downregulated, while TGF-β1 was upregulated in CRC. The expression of lncRNA NLIPMT was negatively correlated with TGF-β1 in CRC. Through the overall survival evaluation, NLIPMT-high groups of CRC represented better survival rate compared to that of the NLIPMT-low group patients. Yes Analysis of cell invasion and migration showed that overexpression of NLIPMT suppressed the tumor cell invasion and migration. In contrast, overexpression of TGF-β1 could promote CRC cell invasion and migration and also reduce the role of NLIPMT. 32765103 NEAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR‑503/SMO axis ) qRT-PCR//MTT//Luciferase Report Assay//Western Blot The RNA expression level of NEAT1 and SMO was significantly elevated in HCC tissues and cells compared with that in the corresponding healthy tissues and cells, which was contrary to miR‑503 expression level. Further studies found that miR‑503 expression was negatively correlated with NEAT1 or SMO. It was also confirmed that NEAT1 directly interacted with miR‑503 and miR‑503 could bind to the 3'‑untranslated region of SMO. Yes NEAT1 silencing was found to restrict the viability, migration and invasion of the cells, while simultaneously induced apoptosis in the HCC cell line. 33398379 MBNL1-AS1 LncRNA Homo sapiens Colonic Neoplasms Interaction[sponging microRNA-412-3p] RNA Pull-Down//Western Blot//FISH//RIP//qRT-PCR//MTT//Luciferase Report Assay//Microarray//Transwell Assay The MBNL1-AS1 was downregulated in colon cancer.Collectively, the present study suggests an inhibitory role of MBNL1-AS1 in colon cancer by upregulating miR-412-3p-targeted MYL9. Thus, this study provides an enhanced understanding of MBNL1-AS1 along with miR-412-3p and MYL9 as therapeutic targets for colon cancer. Yes Moreover, MBNL1-AS1 reversed the CSC-like properties as well as xenograft tumor formation in vivo induced by miR-412-3p. 31255531 MBNL1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[Expression[highly expressed]regulating miR-301b-3p-targeted TGFBR2] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Microarray//Transwell Assay While a poor expression of lncRNA MBNL1-AS1 and TGFBR2, along with a high expression of miR-301b-3p was observed in NSCLC tissues.LncRNA MBNL1-AS1 functioned as a sponge of miR-301b-3p, which inverted the inhibitory role of lncRNA MBNL1-AS1 in CSC proliferation, migration, invasion, drug resistance, and sphere formation in NSCLC. LncRNA MBNL1-AS1 positively regulated TGFBR2 which was a target gene of miR-301b-3p. Yes Expression[up-expression]regulated lncRNA MBNL1-AS1 or depleted miR-301b-3p sExpression[up-expression]pressed the xenograft tumor formation in vivo. 31113460 NCK1-DT LncRNA Homo sapiens Atherosclerosis AS blood samples and ox-LDL stimulated vascular smooth muscle cells Interaction( miR-1197/COX10 axis) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay NCK1-AS1 was significantly upregulated in AS blood samples and ox-LDL stimulated vascular smooth muscle cells (VSMCs). NCK1-AS1 could positively regulate COX10 expression by directly sponging miR-1197. Moreover, co-transfection of sh-NCK1-AS1 and miR-1197 inhibitor, or co-transfection of sh-NCK1-AS1 and pc-COX10 (COX10 overexpressing plasmid) obviously reduced cell viability, promoted cell apoptosis, and increased MDA level in VSMCs followed by ox-LDL treatment for 24 h compared to that in sh-NCK1-AS1 transfected VSMCs. Yes Knockdown of NCK1-AS1 increased cell viability, reduced cell apoptosis and MDA level, and also inhibited the expression of inflammatory cytokines (IL-1β, IL-6 and TNK-α) in ox-LDL stimulated VSMCs. 34986861 circCSNK1G3 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines Interaction(miR-143-3p/HOX pathway) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay By screening for differentially expressed circRNAs, we found that circCSNK1G3 was aberrantly expressed in primary LUAD tissues and cell lines. We also found that circCSNK1G3 can directly interact with and suppress miR-143-3p expression by serving as a 'miR-143-3p sponge'. In addition, we found that circCSNK1G3 can modulate homeobox (HOX) A10 expression through miR-143-3p signaling and, thereby, affect LUAD tumorigenesis. Yes An oncogenic role of circCSNK1G3 was deduced from its aberrant expression and associated enhancement of LUAD A549 and H1299 cell proliferation, migration and invasion. 33118120 hsa_circ_001569 CircRNA Homo sapiens Pancreatic Neoplasms 26 tissues samples and 97 plasma samples from PC patients Expression(highly expressed) Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Invasion Assay//Transwell Assay Results showed that the expression of circ_001569 was upregulated in tissues and plasma of PC patients. High circ_001569 level was positively correlated with lymphatic metastasis, clinical stage, and venous invasion. Circ_001569 level was an independent prognostic indicator for overall survival rates of PC patients, and patients with high circ_001569 level had a poor prognosis. Yes In vitro, circ_001569 silencing decreased cell proliferation, migration, and invasion, but promoted cell apoptosis of PC cells. 33413045 NR2F1-AS1 LncRNA Homo sapiens Thyroid Neoplasms TC tissues Regulation[miRNA-338-3p/CCND1 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay NR2F1-AS1 and CCND1 were overexpressed, whereas miRNA-338-3p was Expression[down-expression]-regulated in TC tissues and cell lines. Yes Expression[down-expression]-regulation of NR2F1-AS1 and CCND1 sExpression[Expression[up-expression]-expression]pressed proliferation and migration of TC cells yet greatly enhanced cell apoptotic rate. Silence of NR2F1-AS1 significantly sExpression[Expression[up-expression]-expression]pressed TC tumorigenesis in vivo. 31304680 NCK1-DT LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction[inhibition of microRNA-134] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay In the present study, it was identified that NCK1-AS1 was significantly upregulated in cervical cancer tissues compared with the levels in adjacent non-tumour tissues. Therefore, the data from the present study suggested that NCK1-AS1 serves a promotive role in cervical cancer cell proliferation and migration by functioning as a molecular sponge for miR-134. High expression levels of NCK1-AS1 were associated with tumour progression and poor prognosis in patients with cervical cancer. Yes Silencing of NCK1-AS1 expression significantly decreased the levels of proliferation and migration of cervical cancer cells, and decreased the protein expression levels of matrix metalloproteinase (MMP)-2 and MMP-9. 31410182 NR2F1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction( miR-642a-3p/NR2F1 Axis) Western Blot//Transfection//qRT-PCR//MTT//Transwell Assay NR2F1-AS1 expression was clearly downregulated in CC tissues and cell lines. Molecular mechanistic experiments showed that NR2F1-AS1 overexpression upregulated NR2F1 expression in CC cells by directly binding to miR-642a-3p, and inhibiting by this way cell viability, proliferation, migration, and invasion in CC. Rescue assays showed that NR2F1 knockdown or miR-642a-3p overexpression offset NR2F1-AS1 upregulation-induced inhibition on CC cell malignant phenotypes. Yes Molecular mechanistic experiments showed that NR2F1-AS1 overexpression upregulated NR2F1 expression in CC cells by directly binding to miR-642a-3p, and inhibiting by this way cell viability, proliferation, migration, and invasion in CC. Rescue assays showed that NR2F1 knockdown or miR-642a-3p overexpression offset NR2F1-AS1 upregulation-induced inhibition on CC cell malignant phenotypes. 36087939 Miat LncRNA Rattus norvegicus Parkinson Disease PD rats Interaction( miR-34-5p/SYT1) FISH//Luciferase Report Assay//Tunel Compared with the normal rats, the downregulation of MIAT was observed in the cortex, hippocampus, substantia nigra, and striatum of the PD rats. Through RNA-sequencing of the PD mice treated with an overexpression of MIAT and through a differentially expressed genes analysis, it was hypothesized that MIAT could upregulate the expression of synaptotagmin-1 (SYT1) through sponging of miR-34-5p. Interactions between MIAT, miR-34-5p, and SYT1 were confirmed using RIP and dual-luciferase reporter assays. Yes Overexpression of MIAT exhibited a neuroprotective effect on the SH-SY5Y cells. 34650678 NCK1-DT LncRNA Homo sapiens Glioma glioma tissues and cells regulation[Wnt/β-catenin pathway,miR-138-2-3p] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP High expression of NCK1-AS1 was found in glioma tissues and cells, especially in U251 cells. Our study suggested that NCK1-AS1 might elevate TRIM24 expression and further activate the Wnt/β-catenin pathway via acting as a ceRNA for miR-138-2-3p. Yes Artificial silencing of NCK1-AS1 or up-regulation of miR-138-2-3p led to inhibited proliferation, invasion and migration but promoted cell apoptosis of U251 cells, while up-regulation of TRIM24 reversed these changes, and it activated the Wnt/β-catenin pathway. The in vitro results were reproduced in in vivo experiments. 32293515 NR2F1-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues regulation[miR-485-5p/miR-218-5p/BIRC5 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The present study demonstrated that NR2F1?AS1 expression is markedly increased in OS, and NR2F1?AS1 was shown to exert oncogenic functions in OS. Finally, it was revealed that silencing of NR2F1‑AS1 repressed the OS cell malignant phenotype by binding with miR‑485‑5p and miR‑218‑5p, and then downregulating BIRC5 expression, which suggests that the NR2F1‑AS1/miR‑485‑5p/miR‑218‑5p/BIRC5 axis could be a potential target for treating OS. Yes Furthermore, a series of experiments suggested that NR2F1?AS1 affects the proliferation, migration, invasion and apoptosis of OS cells by regulating BIRC5. 32945459 NCK1-DT LncRNA Homo sapiens Nasopharyngeal carcinoma cell lines Regulation[Upregulating miR-135a] qRT-PCR//Transwell Assay In the present study, we found that the plasma levels of NCK1-AS1 were significantly higher in NPC patients than the levels in patients with arthritis of the temporomandibular joint (TMJ), as well as healthy participants.The downregulation of lncRNA NCK1-AS1 inhibited cancer cell migration and invasion in NPC by upregulating miR-135a. In the present study, we found that the plasma levels of NCK1-AS1 were significantly higher in NPC patients than the levels in patients with arthritis of the temporomandibular joint (TMJ), as well as healthy participants. No significant difference in plasma levels of NCK1-AS1 was found between TMJ patients and healthy participants. Upregulation of NCK1-AS1 distinguished NPC patients from TMJ patients and healthy participants. Yes NCK1-AS1 siRNA silencing and miR-135a overexpression resulted in inhibited cell migration and invasion, and miR-135a inhibition attenuated the effects of NCK1-AS1 siRNA silencing. 31908525 MVIH LncRNA Homo sapiens Chlorophyll A PDAC tissues,cell lines Expression[highly expressed] qRT-PCR Lnc-MVIH expression was higher in human PDAC cell lines than human normal pancreatic ductal epithelial cell line. In PDAC patients, lnc-MVIH expression was increased in tumor tissue and correlated with advanced tumor size, lymph node metastasis, TNM stage and poor OS. Yes Cell proliferation, migration and invasion were increased in OE-MVIH group compared to OE-NC group, but decreased in KD-MVIH group compared to KD-NC group. 32509206 MEG3 LncRNA Homo sapiens Glioma glioma cells regulation[ miR-6088/SMARCB1 Axis] qRT-PCR//Luciferase Report Assay MEG3 and SMARCB1 expressions were downregulated in glioma cells.Collectively, the evidence in this study indicated that MEG3 was downregulated in glioma cells and inhibited proliferation and migration of glioma cells via regulating miR-6088/SMARCB1 axis. Yes Transfection of pcDNA3.1-MEG3 or pcDNA3.1-SMARCB1 plasmids could clearly block cell proliferation, migration, and EMT progression. 32420340 MVIH LncRNA Homo sapiens Glioblastoma GB cells and tissues Interaction(miR-302a ) Cell Cycle Assay//qPCR//Bioinformatics Analysis//Western Blot The lncRNA associated with microvascular invasion in hepatocellular carcinoma (lncRNA-MVIH), overexpressed in several cancers, was described to co-precipitate with phosphoglycerate kinase 1 (PGK1), preventing secretion of this enzyme to the extracellular environment and promoting cell migration and invasion. We found that the levels of miR-302a loaded onto RISC increased in GB cells after lncRNA-MVIH silencing, with the consequent downregulation of several miR-302a molecular targets. Our findings suggest a new mechanism of action of lncRNA-MVIH as a sponge of miR-302a. Yes We observed that lncRNA-MVIH silencing in human GB cells significantly decreased glycolysis, cell growth, migration, and invasion and sensitized GB cells to cediranib. 33438023 hsa_circ_03955 CircRNA Homo sapiens Pancreatic Neoplasms PC clinical samples Interaction(miR-3662/HIF-1α axis) Transfection//Flow Cytometry//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay In this study, it was investigated that circ_03955 was up-regulated in PC clinical samples as well as PC cell lines and associated with poor clinical outcomes of PC patients.Mechanistically, bioinformatics analysis indicated that circ_03955 acts as a sponge for microRNA (miR)-3662, and hypoxia-inducible factor 1ɑ (HIF-1ɑ) was one of the transcriptional targets of miR-3662. In this study, it was investigated that circ_03955 was up-regulated in PC clinical samples as well as PC cell lines and associated with poor clinical outcomes of PC patients. Yes Functional assays revealed that circ_03955 exerts a certain stimulative effect on the growth of PC cells in vitro and in vivo. Circ_03955 also inhibited apoptosis and promotes Warburg effect in PC cells. 33864618 Miat LncRNA Rattus norvegicus Cerebral Ischaemia/Reperfusion Injury rat cortical neurons Interaction(EGLN2 ) RNA Pull-Down//Western Blot//Co-IP//Tunel//qRT-PCR//IF Results showed that MIAT interacted with EGLN2 in rat cortical neurons. In contrast, MIAT overexpression increased EGLN2 stability after I/R injury via reducing its ubiquitin-mediated degradation. EGLN2 was a substrate of MDM2, a ubiquitin E3 ligase. MDM2 interacted with the N-terminal of EGLN2 and mediated its K48-linked poly-ubiquitination, thereby facilitating its proteasomal degradation. In conclusion, MIAT might act as a stabilizer of EGLN2 via reducing MDM2 mediated K48 poly-ubiquitination. MIAT-EGLN2 axis exacerbates I/R injury via altering redox homeostasis in neurons. Yes MIAT overexpression enhanced infarct volume and induced a higher ratio of neuronal apoptosis. EGLN2 knockdown significantly reversed the injury. 34687132 NCK1-DT LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC cell lines Interaction(miR-137/NCK1 Axis) Western Blot//Transfection//Wound Healing Assay//Tunel//qRT-PCR//Cell Proliferation Assay//Transwell Assay NCK1-AS1 was highly expressed in LSCC cell lines. NCK1, an adjacent gene of NCK1-AS1, is also highly expressed in LSCC cells and was positively regulated by NCK1-AS1. Moreover, NCK1-AS1 interact with miR-137 to upregulate NCK1 expression. NCK1 was the downstream target of miR-137 and was negatively correlated to miR-137. In addition, overexpressed NCK1 reversed the suppressive impact of NCK1-AS1 depletion on malignant behaviors of LSCC cells. Yes NCK1-AS1 depletion suppressed LSCC cell viability, proliferation, invasion, and migration while enhancing cell apoptosis. 35218517 NR2F1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miR-642a/DEK Pathway) qRT-PCR NR2F1-AS1 was significantly upregulated in HCC and associated with the poor prognosis of HCC patients. Biological function experiments revealed that the silence of NR2F1-AS1 suppressed cell invasion and migration in HCC. More importantly, NR2F1-AS1 directly interacted with miR-642a and negatively regulated miR-642a. DEK was the target of miR-642a, and NR2F1-AS1 positively regulated DEK expression by suppressing miR-642a. NR2F1-AS1 was significantly upregulated in HCC and associated with the poor prognosis of HCC patients. Yes Biological function experiments revealed that the silence of NR2F1-AS1 suppressed cell invasion and migration in HCC. 34594378 NR2F1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular human hepatoma cells Expression(highly expressed) CCK8//qRT-PCR//Western Blot The NR2F1-AS1 and H19 levels were high in human hepatoma cells, and AUCs of lncRNA NR2F1-AS1 and lncRNA H19 were both >0.8. The lncRNA NR2F1-AS1 and lncRNA H19 were associated with HCC staging. Yes After transfection of pcDNA3.1-NR2F1-AS1, si-NR2F1-AS1, NC, pcDNA3.1-H19, si-H19 BEL-7402 and Huh-7 cells, silencing NR2F1-AS1 and H19 expression can promote apoptosis and inhibit cell growth, while silencing their over-expression can inhibit the EMT process of Huh-7 cells. 33568940 NR2F1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue regulation[miR-371a-3p/TOB1 Axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot It was observed that NR2F1-AS1 was downregulated in CRC and predicted poor survival.In conclusion, NR2F1-AS1 regulates miR-371a-3p/TOB1 axis to suppress proliferation of CRC cells. It was observed that NR2F1-AS1 was downregulated in CRC and predicted poor survival. Yes Cell proliferation analysis revealed reduced proliferation rate of CRC cells after NR2F1-AS1 and TOB1 overexpression. 32407174 NR2F1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cell lines Regulation[Hedgehog signaling pathway] Northern Blot//ChIP//Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Microarray//Colony Formation Assay//EdU Staining//Transwell Assay In this study, a markedly elevated expression of NR2F1-AS1 was discovered in ESCC cells. Briefly, NR2F1-induced NR2F1-AS1 promotes ESCC progression through activation of Hedgehog signaling pathway. Yes Functional assays demonstrated that NR2F1-AS1 deficiency repressed ESCC progression. 31530388 NR2F1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Interaction(miR-363-3p/SOX4) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The relationships among NR2F1-AS1, miR-363-3p, and SOX4 were detected via dual-luciferase reporter assay. HK-2, GLS1, and SOX4 levels were also analyzed. We found that both NSCLC tissues and cells had higher levels of NR2F1-AS1. Silencing of NR2F1-AS1 inhibited the tumorigenicity of cells in vitro and reduced the glycolysis and glutamine metabolism of NSCLC cells. Regarding its mechanism, NR2F1-AS1 positively regulated the SOX4 level by sponging miR-363-3p. Furthermore, miR-363-3p inhibition or SOX4 overexpression reversed the repressing role of sh-NR2F1-AS1 in the tumorigenicity of NSCLC cells. In summary, NR2F1-AS1 promotes the tumorigenicity of NSCLC cells by regulating miR-363-3p/SOX4. Yes Silencing of NR2F1-AS1 inhibited the tumorigenicity of cells in vitro and reduced the glycolysis and glutamine metabolism of NSCLC cells. 34993348 Miat LncRNA Mus musculus Hypertension, Pulmonary pulmonary tissues,cell line regulation[ Nrf2 pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay MIAT was upregulated in both in vivo and in vitro HPH models, while miR-29a-5p was downregulated.MIAT promotes proliferative and migratory abilities, as well as oxidative stress in hypoxia-induced HPAECs by targeting miR-29a-5p, thus aggravating the development of HPH. Yes Knockdown of MIAT suppressed viability, migratory ability, and oxidative stress in hypoxia-induced HPAECs. 32964992 NCK1-DT LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck blood regulation[downregulating miR-100] qRT-PCR//Transwell Assay The expression of NCK1-AS1 was upregulated in early-stage OSCC patients but not in OU patients. Therefore, NCK1-AS1 may promote the metastasis of OSCC by downregulating miR-100. Yes Overexpression of NCK1-AS1 was followed by promoted OSCC cell invasion and migration. 33194849 NCK1-DT LncRNA Homo sapiens Urinary Bladder Neoplasms UBC tissues and cells regulation[Downregulating miR-143] Flow Cytometry//qRT-PCR//Luciferase Report Assay It was observed that NCK1-AS1 was up-regulated, while miR-143 was down-regulated in tumor tissues than in adjacent healthy tissues of urinary bladder cancer (UBC) patients. Therefore, NCK1-AS1 promotes cancer cell proliferation and increases cell stemness in UBC patients by down-regulating miR-143. A 5-year survival analysis showed that the survival rate of patients with high NCK1-AS1 level or low miR-143 level in tumor tissues appears relatively low. Yes NCK1-AS1 over-expression led to promoted proliferation and increased percentage of CD133+ (stemness) cells. 32184669 circFGFR1 CircRNA Homo sapiens Glioblastoma glioma cells Interaction(hsa-miR-224-5p/CXCR4) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay Here, we state that circFGFR1 is elevated in glioma cells, resulting in aggravated glioma aggravated malignancy. Furthermore, CXCR4 level in glioma cells is positively correlated with circFGFR1 level, and higher CXCR4 expression is found in circFGFR1 overexpression groups.Then, RIP, RNA pull-down, and luciferase reporter assay results showed that hsa-miR-224-5p directly binds to circFGFR1 and CXCR4 mRNA. The CXCR4 3'-untranslated region (UTR) activated luciferase activity was reduced with hsa-miR-224-5p transfection, while it is reversed when cotransfected with circFGFR1, indicating that circFGFR1 acts as a hsa-miR-244-5p sponge to increase CXCR4 expression. Yes The upregulation of circFGFR1 also promotes glioma growth in mouse xenograft models.The effect of circFGFR1 on glioma malignancy is abolished in CXCR4 knockout cells. 35059468 NCK1-DT LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[ Regulating miR-137/NUP43 Axis] Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay NCK1-AS1 was found to have elevated expression in GC tissues and cells in comparison with normal counterparts. In conclusion, the NCK1-AS1/miR-137/NUP43 axis was identified that could contribute to GC malignancy behaviors. Yes Loss-of-function experiments showed knockdown of NCK1-AS1 refrained GC cell proliferation, colony formation, migration, and invasion in vitro. Animal experiments showed silence of NCK1-AS1 suppresses tumor growth in vivo. 33116577 NCK1-DT LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cells Interaction(miR-22-3p/BCL9 axis to activate the Wnt/β-catenin signaling) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Reverse transcription quantitative polymerase chain reaction demonstrated that NCK1-AS1 exhibited high expression in gastric cancer tissues and cells. . Luciferase reporter and RIP assays suggested that NCK1-AS1 functioned as a competitive endogenous RNA (ceRNA) for miR-22-3p to positively modulate BCL9 expression. BCL9 was a target gene of miR-22-3p. According to western blot analysis and TOP/FOP flash assay, NCK1-AS1 activated the Wnt/β-catenin signaling via the miR-22-3p/BCL9 axis. Yes In vitro assays including MTT, colony formation, Transwell, wound healing and sphere formation assays indicated that NCK1-AS1 depletion inhibited cell proliferation, migration, invasion and stemness maintenance 33974352 NCK1-DT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC specimens and cell lines interaction[adsorb miR-137 ] qRT-PCR//Luciferase Report Assay//RNA Pull-Down We observed that NCK1-AS1 expression was upregulated, while miR-137 expression was down-regulated in NSCLC specimens and cell lines. Moreover, NCK1-AS1 was able to adsorb miR-137 via a sponge effect. Overall, our findings suggested that NCK1-AS1 may be a candidate biomarker and a target for new therapies in NSCLC patients. Increased NCK1-AS1 expression was positively correlated with TNM stage and lymph node metastasis and poor clinical outcome. Yes Functionally, knockdown of NCK1-AS1 suppressed the proliferation, migration and invasion of NSCLC cells, and promoted apoptosis. 33194081 NCK1-DT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-512-5p/p21 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//BrdU//Transwell Assay NCK1-AS1 expression was up-regulated in NSCLC tissues and cells, and its high expression was correlated with shorter overall survival time and faster progression of patients. NCK1-AS1 promotes NSCLC progression by regulating miR-512-5p/p21 molecular axis. NCK1-AS1 expression was up-regulated in NSCLC tissues and cells, and its high expression was correlated with shorter overall survival time and faster progression of patients. Yes Overexpression of NCK1-AS1 promoted NSCLC cell proliferation, migration and invasion, and accelerated the cell cycle, whereas NCK1-AS1 siRNA inhibited these malignant biological behaviors, and arrested cell cycle. 32858372 MIAT LncRNA Homo sapiens Sepsis-Induced Myocardial Depression cardiomyocyte, Venous blood samples of 62 patients with sepsis Regulation(NF-κB axis) Western Blot//Flow Cytometry//qRT-PCR//MTT//H&E Staining//ELISA MIAT was highly expressed in SIMD patients. Silencing MIAT alleviated inflammation and apoptosis and improved myocardial function in SIMD rats by downregulating the NF-κB axis. In LPS-induced H9C2 cardiomyocytes, silencing MIAT alleviated inflammation and oxidative stress and inhibited apoptosis by downregulating the NF-κB axis, thus mitigating cardiomyocyte injury. Yes Silencing MIAT alleviated inflammation and apoptosis and improved myocardial function in SIMD rats by downregulating the NF-κB axis. In LPS-induced H9C2 cardiomyocytes, silencing MIAT alleviated inflammation and oxidative stress and inhibited apoptosis by downregulating the NF-κB axis, thus mitigating cardiomyocyte injury. 35636204 NR2F1-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues,cell lines Interaction[PI3K/AKT/GSK-3β pathway] qRT-PCR The expression level of NR2F1-AS1 in tumor tissues and EC cells was measured.miR-363 was negatively regulated by NR2F1-AS1. SOX4 was a target of miR-363. NR2F1-AS1 functioned on EC progression via PI3K/AKT/GSK-3β pathway. The results demonstrated that NR2F1-AS1 was highly expressed in EC, which involved in the proliferation and migration of EC cells through downregulation of miR-363 to target SOX4 and regulating PI3K/AKT/GSK-3β pathway. Yes NR2F1-AS1 inhibition decreased EC cell viability, migration and invasion, while promoted cell apoptosis. 31109400 NR2F1-AS1 LncRNA Homo sapiens Melanoma melanoma tumors and cells Interaction(miR-493-5p/GOLM1 axis) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//EdU Staining//Transwell Assay Up-regulated NR2F1-AS1 and down-regulated miR-493-5p were detected in melanoma tumors and cells.The overexpression of NR2F1-AS1 was induced by STAT3. High NR2F1-AS1 expression was correlMoreover, NR2F1-AS1 was able to up-regulate GOLM1 through recognizing and binding miR-493-5p. Furthermore, knockdown of miR-493-5p distinctly reversed these inhibitory effects of NR2F1-AS1 down-regulation on the tumorigenesis and progression of melanoma.ated to advanced tumor stage and poor prognosis of melanoma. The overexpression of NR2F1-AS1 was induced by STAT3. High NR2F1-AS1 expression was correlated to advanced tumor stage and poor prognosis of melanoma. Yes Functional studies using CCK-8, Edu, transwell and wound healing assays revealed that the proliferative, migratory and invasive capacities of melanoma cells were attenuated by the by inhibition of NR2F1-AS1. 33822440 MEG3 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction(p53 ) Western Blot//Co-IP//Migration Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//IHC//Invasion Assay UXT was upregulated, while MEG3 was downregulated in breast cancer tissues and cell lines. Hypermethylation of the MEG3 imprinting control region was modulated by highly expressed DNMT3b. UXT inhibited MEG3 expression via recruiting DNMT3b to its imprinting control region. MEG3 positively regulated p53 activity. UXT negatively regulated the MEG3/p53 axis in a DNMT3b-dependent manner to promote tumor growth. Yes UXT knockdown or MEG3 overexpression inhibited cell proliferation, promoted apoptosis, and weakened cell migration and invasion. 35229028 NCK1-DT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression(highly expressed) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay The results of qRT-PCR showed that the expression of NCK1-AS1 was up-regulated in 50 out of 64 cases of NSCLC tissues. The results of qRT-PCR revealed that the expression of NCK1-AS1 was also up-regulated in NSCLC cells. It was found via statistical analysis that highly expressed NCK1-AS1 was positively correlated with tumor size, TNM stage and lymph node metastasis. Yes After interference in the expression of NCK1-AS1, the proliferation of NSCLC cells was inhibited, and the cell cycle was arrested at G2/M phase. 33629305 MEG3 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Interaction[PI3K/Akt pathway] qRT-PCR "Our findings showed that MEG3 was downregulated and miR-21 was upregulated in breast cancer patient tissues and cells. In summary, MEG3 overexpression inhibited the tumorigenesis of breast cancer by downregulating miR-21 through the PI3K/Akt pathway. " Yes MEG3 overexpression suppressed cell proliferation and glycolysis, and induced apoptosis in breast cancer cells. 30389444 MTORT1 LncRNA Homo sapiens Breast Neoplasms breast cancer cells Interaction(miR-26a-5p/CREB1 and STK4) Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay Our results showed that MTORT1 had low endogenous expression levels in breast cancer cells and was mainly located in the mitochondria. MTORT1 served as sponge of miR-26a-5p to up-regulate its target genes, CREB1 and STK4. Yes Knockdown of MTORT1 enhanced cell proliferation and migration, implying a tumor suppressor role of this novel mitochondrial lncRNA. 34141617 hsa_circ_0030167 CircRNA Homo sapiens Pancreatic Neoplasms PC cells Interaction(miR-338-5p/wif1/Wnt 8/β-catenin axis) Western Blot//Wound Healing Assay//Migration Assay//CCK8//FISH//Flow Cytometry//qRT-PCR//Colony Formation Assay//Invasion Assay We revealed that circ_0030167 mainly regulates miR-338-5p, enhances Wif1 expression, and inhibits the Wnt8/β-catenin pathway, thereby inhibiting the stemness of PC cells and tumor progression. Overall, BM-MSC exosomal circ_0030167 contributes to the progression and stemness of PC cells via the miR-338-5p/wif1/Wnt 8/β-catenin axis. Yes We revealed that circ_0030167 mainly regulates miR-338-5p, enhances Wif1 expression, and inhibits the Wnt8/β-catenin pathway, thereby inhibiting the stemness of PC cells and tumor progression. Overall, BM-MSC exosomal circ_0030167 contributes to the progression and stemness of PC cells via the miR-338-5p/wif1/Wnt 8/β-catenin axis. 33971282 circFOXM1 CircRNA Homo sapiens Glioblastoma GBM tumor tissues and cells Interaction(miR-577/E2F5 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay Our results showed that circFOXM1 was highly expressed in GBM tumor tissues and cells. MiR-577 could be sponged by circFOXM1, and its inhibitor could reverse the suppressive effect of circFOXM1 downregulation on GBM progression. E2F5 was a target of miR-577, and the effect of its knockdown on GBM progression was consistent with that of circFOXM1 silencing. CircFOXM1 positively regulated E2F5 expression, while miR-577 negatively regulated E2F5 expression. Yes Silencing of cir FOXM1 inhibited GBM cell proliferation, migration, invasion, glutaminolysis, as well as tumor growth. 34784267 NCK1-DT LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cell and tissues Regulation( TGF-β1) qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay Our data showed that plasma NCK1-AS1 was overexpressed in ESCC patients and positively correlated with NCK1-AS1 expression in tumor tissues but not in non-tumor tissues. TGF-β1 expression level was also increased in tumor tissues compared to the adjacent normal tissues and positively correlated with NCK1-AS1 in tumor tissues. TGF-β1 overexpression in ESCC cells did not affect NCK1-AS1 expression, while NCK1-AS1 overexpression in ESCC cells upregulated TGF-β1.oreover, TGF-β1 and NCK1-AS1 overexpression increased ESCC cell migration and invasion, while TGF-β inhibitor reduced the effects of NCK1-AS1 overexpression. Moreover, high plasma NCK1-AS1 levels were accompanied with poor survival. Yes oreover, TGF-β1 and NCK1-AS1 overexpression increased ESCC cell migration and invasion, while TGF-β inhibitor reduced the effects of NCK1-AS1 overexpression. 35311444 Miat LncRNA Mus musculus Myocardial Infarction MI mice Interaction(miR-10a-5p/EGR2 axis) In Vivo Experiment//Western Blot//Tunel//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay MIAT and EGR2 were subsequently determined to be highly-expressed, whereas miR-10a-5p was found to be poorly-expressed in cardiomyocytes exposed to hypoxia as well as in MI mice using RT-qPCR and Western blot assay. The binding relationships between MIAT and miR-10a-5p, and between miR-10a-5p and EGR2 were further confirmed by dual-luciferase reporter and RNA immunoprecipitation assays. Yes The results of in vitro and in vivo experimentation also suggested that overexpression of miR-10a-5p or silencing of MIAT and EGR2 reduced cardiomyocyte apoptosis and increased ATP content, thus alleviating the impairment of cardiac function following MI. 33819189 circZMYM4 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines Interaction(miR-587/ODAM pathway) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//Invasion Assay//Tunel//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay We found that circZMYM4 was distinctly down-regulated in LUAD tissues and cell lines. Importantly, circZMYM4 upregulated ODAM expression via sponging miR-587 to suppress LUAD progression. Yes Functional assays revealed that circZMYM4 overexpression suppressed LUAD cell proliferation, metastasis and suppressed apoptosis, while miR-587 overexpression could weaken these effects. 34634673 hsa_circ_0060055 CircRNA Homo sapiens Glioblastoma GBM tumor tissues and cells Interaction(MiR-197-3p/API5 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ_0060055 was overexpressed in GBM tumor tissues and cells, and its silencing suppressed GBM cell proliferation and invasion, while promoted apoptosis and radiosensitivity. In terms of mechanism, circ_0060055 could interact with miR-197-3p, and miR-197-3p could target API5. API5 expression also could be positively regulated by circ_0060055. Function experiments suggested that miR-197-3p inhibitor abolished the effect of circ_0060055 knockdown on GBM cell growth, invasion, and radiosensitivity. MiR-197-3p repressed GBM cell progression and improved radiosensitivity, and this effect was eliminated by API5 upregulation. Yes In vivo experiments confirmed that circ_0060055 knockdown reduced GBM tumor growth and enhanced the radiosensitivity of tumors. 35849320 NCK1-DT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues Interaction(miR-22-3p/YARS Axis ) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay NCK1-AS1 was overexpressed in HCC cells and tissues. NCK1-AS1 controlled the availability of miR-22-3p, resulting in YARS upregulation. YARS was found to have a clinical value for HCC diagnosis. Moreover, rescue experiments revealed that miR-22-3p inhibition or YARS overexpression partially blocked the function of NCK1-AS1 deficiency in HCC cells. As for the downstream signaling pathway, we discovered that NCK1-AS1 activated PI3K/AKT signaling by the miR-22-3p/YARS axis. Yes Functional assays depicted that depletion of NCK1-AS1 hampered malignant character of HCC cells. 35306563 circPTK2 CircRNA Homo sapiens Glioblastoma paired cancer and non-cancer tissues from glioblastoma patients Interaction(miR-23a Maturation) qRT-PCR//Transwell Assay We found that circPTK2 was downregulated in GBM and was inversely correlated with mature miR-23a, but not premature miR-23a. GBM cells transfected with circPTK2 expression vector showed significantly downregulated mature miR-23a, but not premature miR-23a. Transwell assay analysis showed that circPTK2 overexpression decreased cell invasion and migration, while miR-23a increased cell invasion and migration. Moreover, miR-23a overexpression reversed the inhibitory effects of circPTK2 overexpression on cell behaviors. Yes Transwell assay analysis showed that circPTK2 overexpression decreased cell invasion and migration, while miR-23a increased cell invasion and migration. Moreover, miR-23a overexpression reversed the inhibitory effects of circPTK2 overexpression on cell behaviors. 34456566 circCCT3 CircRNA Homo sapiens Pancreatic Neoplasms PC tissues Interaction( VEGFA/VEGFR2 Signaling) In Vivo Experiment//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Bioinformatics Analysis CircCCT3 expression was significantly increased in PC tissues (3.41 ± 0.57 vs. 1.00 ± 0.10, P < .01) and cell lines (Patu8988 2.57 ± 0.20; SW1990 2.88 ± 0.10; BxPC-3 2.45 ± 0.20; Panc02 2.99 ± 0.10 vs. H6c7 1.00 ± 0.10; all P < .001). CircCCT3 expression was negatively correlated with miR-613 expression. The CircCCT3 acted as a sponge for the miR-613 to facilitate VEGFA and VEGFR2 expression. PC patients with high CircCCT3 expression exhibited significantly poorer overall survival rate than those patients with low CircCCT3 expression (P = .013). Yes Moreover, it was found that CircCCT3 promoted cell proliferation, migration, and invasion, and inhibited cell apoptosis in PC cells. si-CirCCT3 also inhibited tumor growth of PC in nude mice. 34274912 NCK1-DT LncRNA Homo sapiens Melanoma melanoma cell lines Interaction(miR-526b-5p/ADAM15 axis) In Vivo Experiment//RNA Pull-Down//Transfection//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay NCK1-AS1 was overexpressed in melanoma cell lines and NCK1-AS1 knockdown hampers the proliferation and migration of melanoma cells. Besides, miR-526b-5p binds to NCK1-AS1 in melanoma and ADAM15 was validated as its downstream target. Further, the inhibitory effects of NCK1-AS1 knockdown on cell proliferation and migration in melanoma were reversed by the depletion of miR-526b-5p and further counteracted by ADAM15 knockdown. The growth of melanoma tumors was hindered by the down-regulation of NCK1-AS1 or up-regulation of miR-526b-5p. Yes NCK1-AS1 was overexpressed in melanoma cell lines and NCK1-AS1 knockdown hampers the proliferation and migration of melanoma cells. Besides, miR-526b-5p binds to NCK1-AS1 in melanoma and ADAM15 was validated as its downstream target. Further, the inhibitory effects of NCK1-AS1 knockdown on cell proliferation and migration in melanoma were reversed by the depletion of miR-526b-5p and further counteracted by ADAM15 knockdown. 34247598 MEG3 LncRNA Homo sapiens Breast Neoplasms cell lines Expression[highly expressed] qRT-PCR//Wound Healing Assay//IF Interestingly, using a panel of seven different breast cancer cell lines, the present study revealed that MEG3 is highly expressed in the triple negative metastatic human Hs578T breast cancer cell line, which is refractory to different therapeutic approaches. Yes The results demonstrated that MEG3 deletion increased cell proliferation, anchorage-independent cell growth and cell motility, which was consistent with its well-known tumor suppressor function. 31788068 circNUP98 CircRNA Homo sapiens Glioblastoma 58 GB tissue samples Interaction( miR-519a-3p) In Vivo Experiment//RNA Pull-Down//qRT-PCR//Luciferase Report Assay//BrdU Heatmap analysis showed that circNUP98 and pre-mature miR-519a-3p were upregulated in GB, while mature miR-519a-3p was downregulated in GB. Across the cancer tissues, circNUP98 was inversely correlated with mature miR-519a-3p, but positively correlated with pre-mature miR-519a-3p.CircNUP98 suppresses the maturation of miR-519a-3p to promote GB cell proliferation. Yes BrdU and cholecystokinin octapeptide (CCK-8) assays illustrated that overexpression of circNUP98 reduced the inhibitory effects of miR-519a-3p on cell proliferation.CircNUP98 contributed to larger tumors, which resulted in significantly reduced mice survival. 34867700 NR2F2-AS1 LncRNA Homo sapiens Pancreatic Neoplasms cell lines Interaction[regulates CDK4] Cell Cycle Assay//qPCR//Western Blot We showed that NR2F2-AS1 was upregulated in PC and positively correlated with CDK4.. In addition, CDK4 overexpression reduced the effects of NR2F2-AS1 siRNA silencing. Therefore, NR2F2-AS1 positively regulates CDK4 to promote cancer cell proliferation in PC. Follow-up study revealed that high levels of NR2F2-AS1 and CDK4 in PC tissues were closely correlated with the poor survival of PC patients. Yes Cell proliferation data showed that NR2F2-AS1 overexpression led to increased, while NR2F2-AS1 siRNA silencing led to proliferation rate of PC cells. 31566058 MGC27382 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Regulation( AKT/GSK3β pathway) Western Blot//Wound Healing Assay//qRT-PCR//Cell Cycle Assay//Transwell Assay We detected that DElncRNA MGC27382 is down-regulated in NSCLC tissues and cells. Further studies demonstrated that MGC27382-mediated inhibition on NSCLC progression can be impaired by LY294002, which is a frequently used inhibitor of AKT/GSK3β pathway. Yes Overexpression of MGC27382 prevented NSCLC cell proliferation via down-regulating cyclin D1 and cyclin E. Moreover, wound healing and transwell assays indicated that the ability of cell invasion and migration could be impaired when cells were treated with MGC27382 overexpression. 34224057 MYCNOS LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction[ regulating miR-340] RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, MYCNOS was up-regulated in both HCC tissues and cell lines, and elevated MYCNOS expression was correlated to shorter survival time of HCC patients.In addition, MYCNOS acted as a negative regulator of miR-340 in HCC cells, and all effects of MYCNOS knockdown were abrogated by further miR-340 inhibition. We also discovered that oncogene phosphatidylinositol-3, 4, 5-trisphosphate-dependent Rac exchange factor 2 (PREX2) was a downstream target of miR-340, and PREX2 expression was positively correlated to that of MYCNOS in HCC tissues. In conclusion, our findings demonstrated that MYCNOS knockdown inhibited HCC progression through regulating miR-340. In the present study, MYCNOS was up-regulated in both HCC tissues and cell lines, and elevated MYCNOS expression was correlated to shorter survival time of HCC patients. Yes MYCNOS knockdown significantly inhibited proliferation in HCC cells in vitro accompanied by exacerbated cell apoptosis; it also suppressed tumor growth in mouse model in vivo. Besides, the migration and invasion of HCC cells were remarkably inhibited after MYCNOS knockdown. 31776854 NR2F2-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Interaction[PTEN] Cell Proliferation Assay//qRT-PCR//Cell Apoptosis Assay//Western Blot The results demonstrated that NR2F2-AS1 and PTEN expression levels were significantly higher (Fig. 1A) and lower (Fig. 1B), respectively, in NPC tissues compared with non-tumor tissues (P<0.05). In conclusion, NR2F2-AS1 downregulation decreased proliferation and increased apoptosis of NPC cells via upregulation of PTEN. Furthermore, upregulated NR2F2-AS1 expression levels and downregulated PTEN expression levels in NPC tissues predicted less favorable survival outcomes in patients with NPC. Yes In addition, NR2F2-AS1 silencing and PTEN overexpression resulted in decreased proliferation and an increase in the apoptotic rate of NPC cells. 31966043 MEG3 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines (MKN74, MKN45, SGC7901, AGS) Interaction [MEG3/miR-21 axis ] Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay Our data showed that down-regulated MEG3 was observed in GC tissues and cell lines (MKN74, MKN45, SGC7901, AGS).Besides that, the targeting relationship between MEG3 and miR-21 was firstly revealed by bioinformatics prediction. In summary, our study revealed the regulating role of MEG3/miR-21 axis in GC progression and provided a new potential therapeutic strategy for GC treatment. Yes Overexpressed MEG3 by pcDNA3.1-MEG3 transfection suppressed cell proliferation, migration and invasion of GC cells remarkably.Finally, the mice tumor model experiments showed that overexpressed MEG3 could also inhibit tumor growth and metastasis in vivo through inhibiting miR-21 expression. 29710493 hsa_circ_0007142 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues regulation[Circ_0007142/miR-186/FOXK1 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay And circ_0007142 expression was the most upregulated in five lung adenocarcinoma tissues.Altogether, our study suggests Circ_0007142/miR-186/FOXK1 axis may play as an important role in progression of lung adenocarcinoma, which provided a novel potential mechanism about this disease. Yes In addition, knockdown of circ_0007142 inhibited proliferation, migration, invasion and induced apoptosis of lung adenocarcinoma cells. 32913545 NR2F2-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cells regulation[miR-4429/MBD1 axis ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, our results revealed that NR2F2-AS1 expression was up-regulated in cervical cancer tissues and cells, notably in patients with advanced cervical cancer.To sum up, these results suggested the potential mechanism of NR2F2-AS1 in cervical cancer and revealed that NR2F2-AS1 exerted its carcinogenic effect via regulating miR-4429/MBD1 axis, indicating a promising insight into the therapeutic target of cervical cancer. Yes NR2F2-AS1 accelerated progression of cervical cancer by facilitating cell proliferation, migration, invasion, and EMT process, but inhibiting cell apoptosis. 32469064 MYCNUT LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] qRT-PCR The data showed the significant up-regulation of lncUSMycN in tumor tissues compared to non-tumor specimens (95% CI, p = 0.002). Yes Furthermore, lncUSMycN knockdown induced apoptosis and suppressed cellular migration in breast cancer cells (p < 0.01). 31102367 NR2F2-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(miR-425-5p-mediated HMGB2) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//BrdU//Transwell Assay In comparison to adjacent non-tumor tissues, OS tissues showed upregulated NR2F2-AS1 expression. . Mechanistically, NR2F2-AS1 hampered miR-425-5p expression as its competitive endogenous RNA (ceRNA). Thus, NR2F2-AS1 facilitated the HMGB2 expression. However, miR-425-5p inhibited HMGB2 expression by targeting the latter. Higher NR2F2-AS1 level was predominantly correlated with worse clinical stages. Yes In vivo and in vitro tests corroborated that NR2F2-AS1 overexpression spurred OS cell proliferation, growth, invasion, and choked apoptosis. 36269529 circMELK CircRNA Homo sapiens Glioblastoma GBM tissues Interaction(miR-593/EphB2 axis) Western Blot//Migration Assay//qRT-PCR//FISH//RIP//Invasion Assay We demonstrated that circMELK was upregulated in GBM, acting as an oncogene and regulating GBM mesenchymal transition and GSC maintenance via sponging of miR-593. We have proved that circMELK functions as a sponge for tumor suppressor microRNA-593 (miR-593) by RNA immunoprecipitation and circRNA precipitation assays, which targets the oncogenic gene Eph receptor B2 (EphB2). Dual-luciferase reporter assays were adopted to estimate the interactions between miR-593 and circMELK or EphB2. Yes We have proved that circMELK functions as a sponge for tumor suppressor microRNA-593 (miR-593) by RNA immunoprecipitation and circRNA precipitation assays, which targets the oncogenic gene Eph receptor B2 (EphB2). 34168916 hsa_circ_0000284 CircRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells Interaction( miR-1179/RHPN2 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tube Formation Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Circ_0000284 was significantly upregulated in PC tissues and cells, and its knockdown inhibited PC cell proliferation, migration, invasion, and angiogenesis while promoting apoptosis.To sum up, our data confirmed that circ_0000284 facilitated PC malignant progression depending on the regulation of miR-1179/RHPN2 axis, suggesting that circ_0000284 might be a potential target for PC treatment. Yes Circ_0000284 was significantly upregulated in PC tissues and cells, and its knockdown inhibited PC cell proliferation, migration, invasion, and angiogenesis while promoting apoptosis. 36536496 NBR2 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[downregulating miRNA-21] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that NBR2 was downregulated in colorectal cancer tissues than in adjacent healthy tissues.NBR2 overexpression downregulated miRNA-21 in colorectal cancer cells, while miRNA-21 overexpression failed to significantly affect NBR2 expression.NBR2 overexpression suppressed migration and invasion of colorectal cancer cells. MiRNA-21 overexpression played an opposite role and attenuated the effects of NBR2 overexpression. Yes NBR2 overexpression suppressed migration and invasion of colorectal cancer cells. 31571148 circPDK1 CircRNA Homo sapiens Pancreatic Neoplasms PC tumor tissues and serum exosomes Interaction(miR-628-3p/BPTF/c-myc axis) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//ISH//Transfection//Migration Assay//FISH//qRT-PCR//IF//RIP//Luciferase Report Assay//Cell Proliferation Assay//IP//IHC//Transwell Assay CircPDK1 was highly abundant in PC tumor tissues and serum exosomes and was associated with poor survival.Mechanistically, circPDK1 could be activated by HIF1A at the transcriptional level and sponges miR-628-3p to activate the BPTF/c-myc axis. CircPDK1 was highly abundant in PC tumor tissues and serum exosomes and was associated with poor survival. Yes Exosomal circPDK1 significantly promoted PC cell proliferation, migration, and glycolysis both in vitro and in vivo. 36068586 NR2F2-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC TISSUES Interaction(miR-494) qRT-PCR NR2F2-AS1 expression was downregulated in OSCC and positively correlated with miR-494 expression.In OSCC cells, NR2F2-AS1 overexpression upregulated miR-494 level, while NR2F2-AS1 silencing decreased miR-494 expression.MSP results showed that NR2F2-AS1 overexpression decreased miR-494 methylation while NR2F2-AS1 silencing increased miR-494 methylation. Yes In addition, NR2F2-AS1 silencing increased OSCC cell proliferation rate while overexpression of miR-494 and NR2F2-AS1 decreased OSCC cell proliferation. Furthermore, miR-494 overexpression attenuated the effects of NR2F2-AS1 silencing on cell proliferation. 34896865 MEG3 LncRNA Homo sapiens Stomach Neoplasms Gastric Cancer tissues Expression[lower expressed] Flow Cytometry//Wound Healing Assay//Colony Formation Assay//Transwell Assay Bioinformatics analysis showed that lncRNA MEG3 and ATP4B were downregulated in gastric cancer tissues compared with normal tissues. Yes The overexpression of MEG3 and the application of 5-Aza treatment inhibited the migration, invasion and proliferation of MGC-803 cells and promoted apoptosis. Once the expression of MEG3 is restored or methylation is inhibited, tumor growth can be inhibited both in vivo and in vitro. 31584879 NR2F2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[downregulating CDK6] CCK8//qRT-PCR//Western Blot We found that NR2F2-AS1 and cyclin-dependent kinase 6 (CDK6) were both upregulated in CRC and were positively correlated. NR2F2-AS1 siRNA silencing led to decreased rate of CRC cell proliferation. CDK6 overexpression attenuated the effects of NR2F2-AS1 siRNA silencing on cancer cell proliferation. High expression levels of NR2F2-AS1 were closely correlated with low overall 5-year survival rate. Yes NR2F2-AS1 siRNA silencing led to decreased rate of CRC cell proliferation. CDK6 overexpression attenuated the effects of NR2F2-AS1 siRNA silencing on cancer cell proliferation. 31432342 NR2F2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-545-5p / c-Met/BVR/ATF-2 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//FISH//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our results showed that lncRNA NR2F2-AS1, c-Met, BVR and ATF-2 were overexpressed while miR-545-5p was silenced in NSCLC tissues and cells. Silencing of lncRNA NR2F2-AS1 or upregulating miR-545-5p significantly inhibited the cell proliferation, migration, invasion and EMT process. The EMT process could be inhibited by suppressing c-Met/BVR/ATF-2 axis. LncRNA NR2F2-AS1 promoted the NSCLC development through suppressing miR-545-5p to activate EMT process through c-Met/BVR/ATF-2 axis. Yes Silencing of lncRNA NR2F2-AS1 or upregulating miR-545-5p significantly inhibited the cell proliferation, migration, invasion and EMT process. The EMT process could be inhibited by suppressing c-Met/BVR/ATF-2 axis. The tumor xenograft experiments demonstrated that the tumor growth and EMT process were significantly inhibited by silencing lncRNA NR2F2-AS1 or overexpression of miR-545-5p in vivo. 34765296 NR2F2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[targeting miR-320b] Western Blot//Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay//Transwell Assay As a result, elevated expression of NR2F2-AS1 was detected in NSCLC tissues and cells and was remarkably associated with the tumor, node, metastasis (TNM) stage and the status of lymphatic metastasis of patients.Through bioinformatics analysis, NR2F2-AS1 functions as a ceRNA directly binding to miR-320b, BMI1 was a direct target of miR-320b. Combined with the following cellular experiments, the data showed that NR2F2-AS1 may influence the NSCLC cell proliferation, invasion and apoptosis through regulating miR-320b targeting BMI1. As a result, elevated expression of NR2F2-AS1 was detected in NSCLC tissues and cells and was remarkably associated with the tumor, node, metastasis (TNM) stage and the status of lymphatic metastasis of patients. Yes Down-regulated NR2F2-AS1 contributed to the promotion of cell apoptosis and the inhibition of cell proliferation and invasion in A549 and SPC-A-1 cells in vivo and vitro. 30592135 NR2F1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC cells Regulation RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//CCK8//RIP//Luciferase Report Assay//Bioinformatics Analysis//Transwell Assay The results of the present study revealed that the knockdown of NR2F1-AS1 inhibited the proliferation, invasion and migration of GC cells. NR2F1-AS1 also upregulated the expression levels of ST8SIA1 by recruiting transcriptional factor SPI1. Yes The results of the present study revealed that the knockdown of NR2F1-AS1 inhibited the proliferation, invasion and migration of GC cells. 34738863 NCK1-DT LncRNA Homo sapiens lung squamous cell carcinoma LUSC tissues and LUSC cells Interaction(NCK1/MYC) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//FISH//migration assay//Luciferase Report Assay//Cell Proliferation Assay//ChIP Through online bioinformatics analysis, we obtained a high NCK1-AS1 level in LUSC tissues. Meanwhile, we confirmed that NCK1-AS1 was upregulated in LUSC cells.Mechanistically, we revealed that NCK1-AS1 induced the upregulation of its nearby gene NCK adaptor protein 1 (NCK1) at the transcriptional level by interacting with the transcription factor MYC proto-oncogene (MYC). Rescue assays indicated that NCK1 participated in the regulation of NCK1-AS1 on LUSC progression. Yes Gain- or loss-of-function assays suggested that NCK1-AS1 prompted cell proliferation and migration, whilst impeded cell apoptosis in LUSC. 33629937 MEG3 LncRNA Homo sapiens Breast Neoplasms Interaction[activating NF-κB and p53] Western Blot//Tunel//Flow Cytometry//qRT-PCR//MTT//IF Moreover, ectopic expression of MEG3 increased the expression of endoplasmic reticulum (ER) stress-related proteins required for unfolded protein response, including glucose-regulated protein 78 (GRP78), inositol-requiring enzyme 1 (IRE1), protein kinase RNA (PKR)-like ER kinase (PERK), and activated transcription factor 6 (ATF6), as well as proapoptotic proteins CCAAT/enhancer binding protein homologous protein (CHOP) and caspase-3. Finally, MEG3 overexpression markedly increased nuclear factor κB (NF-κB) expression, NF-κB translocation to the nucleus, and p53 expression, whereas pharmacological inhibition of NF-κB completely abolished MEG3-induced activation of p53. Together, these results suggest that MEG3 inhibits breast cancer growth and induces breast cancer apoptosis, partially via the activation of the ER stress, NF-κB and p53 pathways, and that NF-κB signaling is required for MEG3-induced p53 activation in breast cancer cells. Our results indicate targeting lncRNA MEG3 may represent a novel strategy for breast cancer therapy. Yes MEG3 overexpression led to marked increase of apoptosis in breast cancer cells as determined using flow cytometry and fragmented DNA labeling. 30556250 MVIH LncRNA Homo sapiens Leukemia, Myeloid, Acute cell lines Interaction[downregulating miR-505] CCK8//qRT-PCR//Western Blot Lnc-MVIH expression was elevated in AML-193, KG-1, OCI-AML2 cell lines, but similar in HL-60 cell line compared with primary normal BMMC. Lnc-MVIH knockdown inhibits cell proliferation but promotes cell apoptosis via regulating miR-505 mediated HMGB1 and CCNE2 in AML. Yes Lnc-MVIH knockdown inhibited cell proliferation but promoted cell apoptosis in KG-1 cells, meanwhile miR-505 expression was increased by lnc-MVIH knockdown in KG-1 cells. 35117009 NR2F1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells regulation[NR2F1-AS1/miR-493-5p/ITGB1 axis] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay Our results showed that NR2F1-AS1 expression was upregulated in NSCLC cells, and notably, its upregulation was correlated with adverse clinical characteristics and shorter overall survival in patients with NSCLC. In summary, the NR2F1-AS1/miR-493-5p/ITGB1 pathway initiates pro-oncogenic behavior in NSCLC tumor progression, and the NR2F1-AS1/miR-493-5p/ITGB1 axis may provide new molecular targets for anticancer therapy against NSCLC. Our results showed that NR2F1-AS1 expression was upregulated in NSCLC cells, and notably, its upregulation was correlated with adverse clinical characteristics and shorter overall survival in patients with NSCLC. Yes The absence of NR2F1-AS1 functionally decreased NSCLC cell proliferation, migration, and invasion and promoted tumor cell apoptosis. In addition, the tumor growth of NSCLC cells in vivo was inhibited after NR2F1-AS1 silencing. 32784268 hsa_circ_000881 CircRNA Homo sapiens Adenocarcinoma of Lung 40 pairs of LUAD and para-carcinoma normal tissues Interaction(miR-665/PRICKLE2 axis) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis//Transwell Assay Circ-000881 was remarkably downregulated in LUAD. The results of luciferase reporter assay and bioinformatics analysis confirmed that circ-000881 served as a sponge for miR-665, and PRICKLE2 was a direct target of miR-665. Yes Overexpression of circ-000881 attenuated cell growth, migration, and invasion, whereas its knockdown enhanced the malignancy of LUAD cells. 33850895 hsa_circ_0099999 CircRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues and cells Regulation(circ_0099999/miR-330-5p/FSCN1 ceRNA crosstalk) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay Circ_0099999 was highly up-regulated in pancreatic cancer tissues and cells. Knockdown of circ_0099999 impeded cell proliferation, migration, invasion, glycolysis, and promoted apoptosis in vitro, as well as diminished tumour growth in vivo. Circ_0099999 targeted miR-330-5p, and miR-330-5p was a downstream mediator of circ_0099999 function. FSCN1 was a direct and functional target of miR-330-5p. Furthermore, circ_0099999 operated as a ceRNA for miR-330-5p to modulate FSCN1 expression. Yes Knockdown of circ_0099999 impeded cell proliferation, migration, invasion, glycolysis, and promoted apoptosis in vitro, as well as diminished tumour growth in vivo. 34409897 circABCC3 CircRNA Homo sapiens Glioblastoma glioblastoma tissues and cells Interaction(miR-770-5p/SOX2/PI3K/AKT signaling pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Tube Formation Assay//Migration Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay CircABCC3 and SOX2 expression were dramatically upregulated, while miR-770-5p expression was apparently downregulated in glioblastoma tissues and cells compared with control groups.Additionally, circABCC3 acted as a sponge for miR-770-5p, and miR-770-5p targeted SOX2. MiR-770-5p inhibitors impaired the impacts of circABCC3 silencing on glioblastoma progression, angiogenesis and PI3K/AKT pathway. CircABCC3 expression was higher in stage III glioblastoma tissues than in stage I + II glioblastoma tissues with close correlation with tumor-node-metastasis (TNM) stage. Yes CircABCC3 absence inhibited cell proliferation, migration, invasion, tube formation and the activation of PI3K/AKT pathway, whereas induced cell apoptosis in glioblastoma. Furthermore, circABCC3 knockdown repressed tumor growth in vivo. 33811842 circDCUN1D4 CircRNA Homo sapiens Adenocarcinoma of Lung Tumor tissues and A549 cell lines Expression [lower expressed] qRT-PCR//RNA-seq//CLIP circDCUN1D4 is downregulated in tumor samples under the mediation of DExH-box helicase 9 (DHX9), which inhibits the formation of circRNA by binding inverted repeat Alus (IRAlus) in flanking sequences. circDCUN1D4 depletion promoted invasion in vitro and metastasis in vivo. Downregulated circDCUN1D4 expression is associated with lymph node metastasis and predicts poor prognosis in LUAD patients Yes circDCUN1D4 depletion promoted invasion in vitro and metastasis in vivo. 33425493 circABCC4 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells regulation[miR-3186-3p/TNRC6B axis] qRT-PCR In this study, a notably elevated expression of circABCC4 was found in LUAD tissues and cells. In sum, circABCC4 regulates LUAD progression via miR-3186-3p/TNRC6B axis. Yes Functional assays elucidated that knockdown of circABCC4 significantly impaired LUAD cell proliferation, migration as well as accelerated cell apoptosis. 31960988 MHRT LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues,cell lines Regulation[miR-4529-5p/ROCK2 Axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay We identified that MHRT was ectopically expressed in gastric cancer tissues and cell lines.. Additionally, functional experiments illustrated that miR-4529-5p is particularly responsible for MHRT-mediated regulation of apoptosis. Besides, ROCK2 was identified as a downstream target of miR-4529-5p. Additionally, upregulated MHRT promotes the expression of ROCK2 by inhibiting miR-4529-5p. Yes Moreover, we found that MHRT promotes proliferation and invasion of gastric cancer cells in vitro. 31273599 hsa_circ_0000326 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues interaction[miR-338-3p] qRT-PCR//Western Blot//Luciferase Report Assay//FISH We found that high expression of hsa_circ_0000326 was correlated with tumor size, regional lymph node status and differentiation in human lung adenocarcinoma. Mechanistic studies showed that hsa_circ_0000326 acted as a miR-338-3p sponge and altered the function of miR-338-3p, which in turn upregulated the expression of the downstream target RAB14 and affected the proliferation, migration and apoptosis of lung adenocarcinoma cells. We found that high expression of hsa_circ_0000326 was correlated with tumor size, regional lymph node status and differentiation in human lung adenocarcinoma. Yes Additionally, we conducted gain- and loss-of-function assays and found that hsa_circ_0000326 acted as a positive regulator of cell proliferation and migration and a negative regulator of apoptosis. 32248836 NCAPG2 LncRNA Homo sapiens Lung Neoplasms LUAD tissues and cells Interaction(LncRNA-AL035458.2/hsa-miR-181a-5p Axis) CCK8//qRT-PCR//IHC//Migration Assay In this study, we investigated the role of NCAPG2 in LUAD and found that the expression of NCAPG2 in LUAD tissues was significantly higher than that of NCAPG2 expression in adjacent normal tissues. Finally, we found that AL139385.1 was upregulated in LUAD cancer tissues and cell lines. Knockdown of NCAPG2 inhibited cell proliferation, cell migration, and cell invasion of LUAD in vitro. More importantly, we established the AL035458.2/hsa-miR-181a-5p axis as the most likely upstream ncRNA-related pathway of NCAPG2 in LUAD. Kaplan-Meier survival analysis showed that patients with higher NCAPG2 expression correlated with unfavorable clinical outcomes. Yes Knockdown of NCAPG2 inhibited cell proliferation, cell migration, and cell invasion of LUAD in vitro. 35664767 hsa_circ_0001588 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues and cell lines regulation[miR-524-3p/NACC1 signaling] qRT-PCR//Luciferase Report Assay//Western Blot We found that hsa_circ_0001588 was prominently upregulated in lung adenocarcinoma tissues and cell lines;Together, our results revealed that hsa_circ_0001588 upregulated the expression of NACC1 by combining with miR-524-3p to promote the proliferation, migration, and invasion of lung adenocarcinoma cells, suggesting that hsa_circ_0001588 may be an underlying therapeutic target for lung adenocarcinoma. We found that hsa_circ_0001588 was prominently upregulated in lung adenocarcinoma tissues and cell lines; elevated expression of hsa_circ_0001588 was positively correlated with poor clinicopathological features of lung adenocarcinoma. Yes Functional experiments revealed that hsa_circ_0001588 acts as an oncogene to promote the proliferation, migration, and invasion of lung adenocarcinoma in vitro. 32735888 MHRT LncRNA Homo sapiens Heart Failure blood Expression[lower expressed] qRT-PCR The results demonstrated that expression of lncRNA MHRT in plasma was down-regulated in patients with chronic heart failure compared to that in healthy people. Yes Over-expression of lncRNA MHRT inhibited the apoptosis of human cardiomyocyte cell line AC16 after H2O2 treatment. 31853247 NR2F1-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Interaction( miR-641) CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results revealed that the total survival time of BC patients with high NR2F1-AS1 expression was lower than that of BC patients with low NR2F1-AS1 expression. Mechanistic investigation revealed that NR2F1-AS1 can competitively bind with microRNA-641 (miR-641) in BC. These results revealed that NR2F1-AS1 functioned as an oncogene by sponging miR-641 expression in BC cell progression. Moreover, miR-641 was negatively correlated with NR2F1-AS1 in BC tissues. Yes Moreover, functional experiments demonstrated that knockdown of NR2F1-AS1 inhibited BC cell viability, migration, and invasion abilities, whereas overexpression of NR2F1-AS1 had the opposite effect. 35083026 NR2F1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC cell lines Interaction( miR-29a-3p/VAMP7 axis) Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot In this study, we revealed that NR2F1-AS1 and NR2F1 were both positively correlated with the degree of malignancy and predicted poor prognosis in two independent GC cohorts.. NR2F1-AS1 and NR2F1 were highly co-expressed in pan-tissues and pan-cancers. Depletion of NR2F1-AS1 compromised the expression level of NR2F1 in GC cells. More importantly, transcriptome sequencing revealed a novel ceRNA network composed of NR2F1-AS1, miR-29a-3p, and VAMP7 in GC. The overexpression of VAMP7 predicted poor prognosis in GC. Rescue assay confirmed that NR2F1-AS1 promotes GC progression through miR-29a-3p/VAMP7 axis. In this study, we revealed that NR2F1-AS1 and NR2F1 were both positively correlated with the degree of malignancy and predicted poor prognosis in two independent GC cohorts. Yes Besides, NR2F1-AS1 and NR2F1 can respond to Epithelial-to-mesenchymal transition (EMT) signaling in GC, since their expression was increased by TGF-beta treatment and decreased after stable overexpression of OVOL2 in GC cell lines. Furthermore, NR2F1-AS1 knockdown inhibited the proliferation, migration, invasion and G1/S transition of GC cells. 35082283 NR2F1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-493-5p/MAP3K2 Axis) Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay The increased NR2F1-AS1 and MAP3K2 expressions were discovered in GC tissues and cells compared with control groups. In addition, NR2F1-AS1 was found to be a sponge of miR-493-5p, and MAP3K2 was a downstream gene of miR-493-5p. Moreover, the expression of MAP3K2 was notably reduced by miR-493-5p, and NR2F1-AS1 counteracted the inhibition of miR-493-5p. Yes Knockdown of NR2F1-AS1 and MAP3K2 dramatically suppressed cell proliferation and migration, while it enhanced cell apoptosis in GC cells. 34335755 hsa_circ_0050102 CircRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues and cells Interaction(miR-1182/NPSR1) Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Cell Cycle Assay//Invasion Assay//Transwell Assay Results of real-time quantitative PCR showed that circ-0050102 expressed higher in pancreatic cancers compared with that in adjacent normal tissues. Mechanism research suggested that circ-0050102 could downregulate miR-1182, while miR-1182 could not influence the expression of circ-0050102, and miR-1182 could directly target at NPSR1 and suppress it. Yes In cell functional experiment, downregulation of circ-0050102 could suppress cell proliferation, migration and invasion ability, boost cell apoptosis and arrest cell cycle in both PANC-1 and CFPAC-1 cells. Furthermore, allogeneic transplantation in nude mice was performed and results showed that the inhibition of circ-0050102 could slow down tumor formation in vivo. 33289016 NR2F1-AS1 LncRNA Homo sapiens Stomach Neoplasms cell lines Interaction(miR-190a/PHLDB2/AKT3) Western Blot//Tunel//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Transwell Assay//IF The results of bioinformatics analysis showed that the expression of NR2F1-AS1/miR-190a/PHLDB2 in GC was positively associated with the pathological features, staging, poor prognosis, and EMT process. Thus, our results showed that NR2F1-AS1/miR-190a/PHLDB2 promoted the phosphorylation of AKT3 to induce EMT in GC cells. Yes The results of bioinformatics analysis showed that the expression of NR2F1-AS1/miR-190a/PHLDB2 in GC was positively associated with the pathological features, staging, poor prognosis, and EMT process. 34746118 circPITX1 CircRNA Homo sapiens Glioblastoma GBM tissues and cells Interaction(miR-584-5p/KPNB1 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tube Formation Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//Transwell Assay CircPITX1 was obviously overexpressed in GBM tissues and cells when compared with negative groups. Mechanistically, circPITX1/miR-584-5p/KPNB1 axis regulated GBM process via mediating proliferation, angiogenesis, migration, invasion, and cell cycle process of GBM cells. Yes The functional experiment implied that knockdown of circPITX1 suppressed proliferation, angiogenesis, migration, invasion, and tumor growth in vivo along with induced cell cycle arrest of GBM cells. 33763840 MYCNOS LncRNA Homo sapiens Glioblastoma GBM tissues Interaction( miR-216b/FOXM1 axis) CCK8//qRT-PCR//Luciferase Report Assay//Western Blot MYCNOS was upregulated in GBM tissues compared to the paired non-tumor tissues. MYCNOS is predicted to interact with miR-216b, but overexpression of MYCNOS and miR-216b failed to affect each other's expression significantly. Dual luciferase activity assay showed that MYCNOS and miR-216b could directly interact with each other. MYCNOS overexpression increased the expression of FOXM1, which is a direct target of miR-216b. Yes Cell proliferation assay showed that MYCNOS and FOXM1 overexpression resulted in an increased proliferation rate of GBM cells, while miR-216b overexpression suppressed cell proliferation. Moreover, MYCNOS overexpression suppressed the role of miR-216b. 33871770 NR2F1-AS1 LncRNA Homo sapiens cervical squamous cell carcinoma tumor tissues regulation[miR-17/SIK1 Axis] qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay It was observed that NR2F1-AS1 was significantly downregulated in tumor tissues than in paired non-tumor tissues in CSCC patients. Therefore, NR2F1-AS1 regulates miR-17/SIK1 axis to suppress the invasion and migration of CSCC cells. Yes Transwell assay analysis revealed decreased invasion and migration rates of CSCC cells after NR2F1-AS1 and SIK1 overexpression. 31994002 NR2F1-AS1 LncRNA Homo sapiens Breast Cancer Lung Metastasis Breast cancer tissues  Interaction(NR2F1 and ΔNp63) In Vivo Experiment//RNA Pull-Down//Northern Blot//Flow Cytometry//qRT-PCR//RIP//IF//ChIP The long non-coding RNA (lncRNA) NR2F1-AS1 (NAS1) is up-regulated in the dormant mesenchymal-like BCSCs, and functionally promotes tumor dissemination but reduces proliferation in lungs. Mechanistically, NAS1 binds to NR2F1 mRNA and recruits the RNA-binding protein PTBP1 to promote internal ribosome entry site (IRES)-mediated NR2F1 translation, thus leading to suppression of ΔNp63 transcription by NR2F1. Yes The long non-coding RNA (lncRNA) NR2F1-AS1 (NAS1) is up-regulated in the dormant mesenchymal-like BCSCs, and functionally promotes tumor dissemination but reduces proliferation in lungs. 34475402 NR-104098 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML cells interaction[EZH2,E2F1] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Cell Cycle Assay//ChIP Based on the related analysis results, we identified that lncRNA NR-104098 is a suppressor gene that is significantly upregulated in AML cells. Taken together, these results lead to deeper insight into the mechanism of ATPR-induced AML differentiation and prevent proliferation by inhibiting EZH2 on the transcriptional level. Yes LncRNA NR-104098 could inhibit proliferation and induce differentiation in AML cells in vitro and also play main role in the mouse xenografts. 32296698 Neat1 LncRNA Mus musculus Fuchs' Endothelial Dystrophy corneal endothelial cells Expression(lower expressed) In Vivo Experiment//qRT-PCR//RNA-seq//IHC//IF Unsupervised clustering analysis uncovered nuclear enriched abundant transcript 1 (NEAT1), a long non-coding RNA (lncRNA), as the top expressed gene in the C0-endothelial subpopulation, but markedly downregulated in FECD. Consistent with human corneas, a UVA-induced mouse FECD model validated the loss of NEAT1 expression. Loss of NEAT1 function by an in vivo genetic approach reproduced the exacerbated phenotype of FECD by ablating corneal endothelial cells. Conversely, gain of function by a CRISPR-activated adenoviral delivery system protected corneas from UVA-induced FECD. Our findings provide novel mechanistic insights into the development of FECD, and targeting NEAT1 offers an attractive approach for treating FECD. Yes Loss of NEAT1 function by an in vivo genetic approach reproduced the exacerbated phenotype of FECD by ablating corneal endothelial cells. 35141048 NOTCH1 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cells regulation[miR-449c-5p/MYC/NOTCH1 axis] qRT-PCR In this study, circ-NOTCH1 exhibited increased expression in GC tissues and cells.Above findings explained that circ-NOTCH1 promoted metastasis and stemness in GC by targeting miR-449c-5p/MYC/NOTCH1 axis, suggesting the possibility of circ-NOTCH1 as a therapeutic marker for GC. Yes Suppression of circ-NOTCH1 inhibited cell migration, invasion, tumor spheroids number, and side population ratio. 31943342 MEG3 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Expression[lower expressed] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay MEG3 and miR-361-5p were observed to be significantly downregulated within both osteosarcoma tissues and cell lines, whereas FoxM1 was upregulated in osteosarcoma tissues and cell lines (p < 0.05). Yes MEG3 directly bound to miR-361-5p, and significantly upgraded its expression (p < 0.05). The upregulated MEG3 and miR-361-5p or the downregulated FoxM1 appeared to substantially inhibit proliferation, migration, and invasion of osteosarcoma cells (p < 0.05). 30624782 MEG3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues regulation[MEG3-miR-421-E-cadherin axis] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Firstly, this study demonstrated that the expression of MEG3 was significantly downregulated in HNSCC compared to adjacent normal tissues.This study indicated that the MEG3-miR-421-E-cadherin axis could be a new therapeutic target for HNSCC. Yes Overexpressed MEG3 inhibited cell proliferation, migration, and invasion in vitro. 32277605 MEG3 LncRNA Homo sapiens colorectal adenocarcinoma tumor tissues,Serum Regulation[TGF-β1,sphingosine kinase 1] CCK8//qRT-PCR//MTT//Western Blot MEG3 expression level was decreased in tumor tissues than that in adjacent healthy tissues. Serum level of MEG3 was lower in cancer patients than that in healthy controls, and the serum level decreased with the increased stage of primary tumor. Downregulation of lncRNA MEG3 can promote colorectal adenocarcinoma cell proliferation and inhibit the apoptosis by up-regulating TGF-β1 and its downstream sphingosine kinase 1. Yes MEG3 knockdown and SPHK1 overexpression promoted tumor cell proliferation, but inhibited cell apoptosis. 30556866 circRNF13 CircRNA Homo sapiens Pancreatic Neoplasms PC cell lines Interaction(miR-139-5p/IGF1R Axis) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Transfection//Wound Healing Assay//Invasion Assay//Migration Assay//CCK8//qRT-PCR//FISH//IHC//EdU Staining//Transwell Assay CircRNF13 was overexpressed in PC cell lines compared with the normal pancreatic duct cell line. CircRNF13 could serve as the molecular sponge of miR-139-5p to inhibit its association with IGF1R that eventually accelerated the malignant progression of PC. Yes Additionally, inhibition of circRNF13 impaired the proliferation, migration, and invasion of PC cells. 34899908 Neat1 LncRNA Mus musculus Neuronal Dysfunction Post-Sepsis neuronal cells from septic mice Interaction(Neat1/Hbb axis) RNA Pull-Down//Western Blot//qRT-PCR//FISH//RIP//IF We observed that Neat1 expression was increased in neuronal cells from septic mice and that it directly interacts with hemoglobin subunit beta (Hbb), preventing its degradation. The Neat1/Hbb axis suppressed postsynaptic density protein 95 (PSD-95) levels and decreased dendritic spine density. Neat1 knockout mice exhibited decreased Hbb levels, which resulted in increased PSD-95 levels, increased neuronal dendritic spine density, and decreased anxiety and memory impairment. Neat1 silencing via the antisense oligonucleotide GapmeR ameliorated anxiety-like behavior and cognitive impairment post-sepsis. Yes Neat1 knockout mice exhibited decreased Hbb levels, which resulted in increased PSD-95 levels, increased neuronal dendritic spine density, and decreased anxiety and memory impairment. Neat1 silencing via the antisense oligonucleotide GapmeR ameliorated anxiety-like behavior and cognitive impairment post-sepsis. 35331906 NPBWR2-1 LncRNA Homo sapiens Ovarian Neoplasms cell lines Expression[lower expressed] Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay Compared with IOSE80, lncRNA NPBWR1-2 was downregulated by more than two-fold in all five ovarian cancer cell lines. Yes Moreover, NPBWR1-2 overexpression in the SKOV3 cell line decreased cell viability, inhibited proliferation, migration and invasion, and promoted apoptosis compared with the control cells. 32565993 MEG3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(GATA3) CCK8//qRT-PCR//RIP However, the mechanism underlying MEG3 downregulation in OSCC has not been well characterized. Enhancer-controlled genes positively regulated by MEG3 were functionally enriched for the 'negative regulation of Wnt signaling pathway' term, as determined using metascape. GATA3 was predicted to be a transcription factor for these genes, and was demonstrated to bind to MEG3. Knockdown of GATA3 countered the effects on proliferation, invasion, and increased transcription of HIC1 and PRICKLE1 induced by MEG3 overexpression. Yes Overexpression of MEG3 inhibited the proliferation and invasion of OSCC cells. 36468944 NPCCAT1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Interaction[upregulating YY1] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//migration assay In this study, we identified a novel lncRNA nasopharyngeal carcinoma copy number amplified transcript-1 (NPCCAT1), whose expression is increased in NPC tissues compared with nasopharyngeal normal tissues.Overall, our study identified NPCCAT1 as an oncogenic lncRNA which promotes NPC progression via upregulating YY1, and suggested that lncRNA NPCCAT1 may be a promising therapeutic target for NPC. Yes Functional experiments demonstrated that overexpression of NPCCAT1 promotes NPC cell growth and migration in vitro and NPC tumor growth in vivo. Knockdown of NPCCAT1 suppresses NPC cell grow and migration. 30481541 NEAT1 LncRNA Rattus norvegicus Osteoarthritis OA model Interaction( miR-378) qRT-PCR//Luciferase Report Assay Compared to the control group, NEAT1 was significantly elevated in the model group, and its miR-378 was significantly decreased. Also, the NEAT1 + NC-miR-378 group's cell activity was lower than that of the sh-NEAT1+NC-miR-378 group but higher than that of the NC-NEAT1 + Inh-miR-378 group. Finally, higher fluorescence activity occurred for NEAT1-mutant type (MUT) transfected with Inh-miR-378. Yes Silencing NEAT1 can enhance OA-chondrocyte activity and decrease apoptosis. When NEAT1 and miR-378 were inhibited together, as shown fort the NC-NEAT1 + NC-miR-378 group, NEAT1 expression, as well as the multiplication and apoptosis ability of the OA-model cells, were the same as those of cells transfected with an empty vector, the NC-NEAT1 group. 35687708 MEG3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Expression [lower expressed] Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay The expression of lncRNA MEG3 in the OSCC tissues and cell lines was significantly lower compared with normal tissues and cell lines, respectively. The expression level of MEG3 was related to clinical stage, lymph node metastasis, distant metastasis and survival status. Yes Overexpression of lncRNA MEG3 inhibited the proliferation, migration, and invasion of SCC25 and CAL27 cell lines, induced apoptosis and promoted the expression of p53 gene. 34594425 NEAT1 LncRNA Rattus norvegicus acute myocardial infarction myocardial tissues Interaction(NEAT1/miR-22-3p/Ltb4r1 signaling pathway) RNA Pull-Down//Western Blot//Tunel//RIP//FISH//qRT-PCR//Luciferase Report Assay//ELISA We established that the NEAT1 and Ltb4r1 expressions were increased, while miR-22-3p expression was down-regulated in MI mice following CHD. NEAT1 could competitively bind to miR-22-3p and positively regulate Ltb4r1 expression. Ltb4r1 was the downstream target of miR-22-3p. Moreover, silencing NEAT1 or downregulating Ltb4rl expression resulted in improved cardiac function, reduced infarct size, and declined levels of IL-1β, IL-6, and IL-18. Furthermore, silencing of NEAT1 also inhibited apoptosis by decreasing levels of Cleaved caspase-3 and Bax, and increasing Bcl-2 level through sponging miR-22-3p, resulting in reduced myocardial injury in CHD. Yes silencing NEAT1 or downregulating Ltb4rl expression resulted in improved cardiac function, reduced infarct size, and declined levels of IL-1β, IL-6, and IL-18. Furthermore, silencing of NEAT1 also inhibited apoptosis by decreasing levels of Cleaved caspase-3 and Bax, and increasing Bcl-2 level through sponging miR-22-3p, resulting in reduced myocardial injury in CHD. 34081624 NEAT1 LncRNA Rattus norvegicus Neuralgia microglial cells Interaction(NEAT1/miR-128-3p/AQP4 axis ) In Vivo Experiment//Western Blot//qRT-PCR//RIP//ELISA//IHC SCI rats showed distinctly higher NEAT1 expression compared with that of the control group. ELISA experiment confirmed that the over-expression of NEAT1 enhanced the expression of IL-6, IL-1β, and TNFα in SCI rats. Other related mechanism studies revealed that NEAT13 targeted and inhibited miR-128-3p as its competing endogenous RNA (ceRNA), and enhanced AQP4 expression, while miR-128-3p targeted AQP4 to regulate its expression. Yes ELISA experiment confirmed that the over-expression of NEAT1 enhanced the expression of IL-6, IL-1β, and TNFα in SCI rats. Other related mechanism studies revealed that NEAT13 targeted and inhibited miR-128-3p as its competing endogenous RNA (ceRNA), and enhanced AQP4 expression, while miR-128-3p targeted AQP4 to regulate its expression. 33373887 circCRIMI1 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma serum samples and tissues Expression(lower expressed) qRT-PCR The results revealed that expression levels of hsa_circ_001010, hsa_circ-ZNF609 were significantly elevated while hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_0072309 were lower in lung adenocarcinoma serum samples and tissues than those in healthy controls (p < 0.05). . Meanwhile, hsa_circ_001010 and hsa_circ-ZNF609 were downregulated hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_0072309 were elevated in A549 cells compared with BEAS-2B cells. Notably, higher expressions of hsa_circ_001010, hsa_circ-ZNF609, and lower expressions of hsa_circ-CRIMI1, hsa_circ-BGT2, hsa_circ-EPB41L2, and hsa_circ_0072309 were positively correlated with clin-ical stage, lymph node metastasis, and smoking. Last but not least, patients with higher expressions of hsa_ circ_001010, hsa_circ-ZNF609, and lower expressions of hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_ 0072309 had significantly lower overall survival rates and disease-free rates as well. Yes Knockdown of hsa_circ-CRIMI1, hsa_circ-EPB41L2, or hsa_circ_0072309 and overexpressing of hsa_circ_001010 and hsa_circ-ZNF609 could promote A549 cell apoptosis but inhibits proliferation as well. 34383411 NPPA-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cell lines Interaction(miR-302e/DKK1/Wnt/β-catenin signaling pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//ELISA//Colony Formation Assay//ChIP In this study, NPPA-AS1 was discovered to be lowly expressed and upregulation of it impaired cell proliferation and migration in CC. Molecular mechanism assays uncovered that increased expression of NPPA-AS1 could inactivate Wnt/β-catenin signaling pathway in CC. In addition, NPPA-AS1 was found to negatively interact with miR-302e whereas positively correlate with dickkopf-1 (DKK1, an inhibitor of Wnt pathway) in CC. Besides, loss of function assay illuminated that miR-302e inhibition restrained cell proliferation and migration in CC. Yes In this study, NPPA-AS1 was discovered to be lowly expressed and upregulation of it impaired cell proliferation and migration in CC. Besides, downregulation of it led to opposite results. 32965043 MEG3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Regulation[JAK-STAT pathway] qRT-PCR It has been reported that long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) was downregulated in OSCC tissues, however, its functional mechanism remains uncertain. Together, our results revealed that MEG3 could modulate JAK-STAT pathway via miR-548d-3p/SOCS5/SOCS6 to suppresses migration and promote apoptosis in OSCC. Yes In addition, the overexpression of MEG3 inhibited tumor migration and facilitated apoptosis in vivo. 30809930 circGLIS3 CircRNA Homo sapiens Glioblastoma GBM cells Regulation(miR-449c-5p) RNA Pull-Down//Western Blot//Bioinformatics Analysis//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining CircGLIS3 was up-regulated in GBM cells and knockdown of circGLIS3 significantly hampered proliferation and promoted apoptosis of GBM cells. Furthermore, circGLIS3 positively regulated CAPG and GLIS3 by sponging miR-449c-5p to affect GBM cell proliferation and apoptosis. Yes CircGLIS3 was up-regulated in GBM cells and knockdown of circGLIS3 significantly hampered proliferation and promoted apoptosis of GBM cells. 36114444 MEG3 LncRNA Homo sapiens Hemangioma involuting phase HAs and normal skin tissues Regulation[miR-494 and regulating PTEN/PI3K/AKT pathway] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay The expression of MEG3 was substantially decreased and had a negative correlation with VEGF expression in proliferating phase HAs, as compared with the involuting phase HAs and normal skin tissues.Our findings suggested that lncRNA MEG3 inhibited HAs tumorigenesis by sponging miR-494 and regulating PTEN/PI3K/AKT pathway. Yes Ectopic expression of MEG3 suppressed cell proliferation, colony formation and induced cycle arrest in vitro and in vivo, followed by the downregulation of VEGF and cyclinD1, but knockdown of MEG3 reversed these effects. 30562741 MEG3 LncRNA Homo sapiens Urinary Bladder Neoplasms BC cells and tissues regulation[PI3K/AKT/mTOR pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining MEG3 was down-regulated with increased expression of miR-93-5p in BC cells and tissues. lncRNA MEG3 could function as a competing endogenous RNA of miR-93 to regulate the tumorigenesis of BC via PI3K/AKT/mTOR pathway. Yes MEG3 overexpression inhibited cell proliferation and the expression of proliferation-, apoptosis- and autophagy-related proteins. 35117516 circZNF652 CircRNA Homo sapiens Glioblastoma GBM tissues and cell lines Interaction(miR-486-5p/SERPINE1 signaling ) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The present study found that CircZNF652 and SERPINE1 were upregulated, while miR-486-5p was downregulated in GBM tissues and cell lines, and GBM patients with high expression of CircZNF652 and SERPINE1, and patients with low expression of miR-486-5p tended to have a worse prognosis. Next, the underlying mechanisms were investigated, and we found that circZNF652 sponged miR-486-5p to upregulate SERPINE1 in GBM cells. Also, we validated that knock-down of circZNF652 regulated the miR-486-5p/SERPINE1 axis to reverse the malignant phenotypes in GBM cells. Interestingly, we noticed that GBM cells derived exosomes were characterized by high-expressed CircZNF652. The present study found that CircZNF652 and SERPINE1 were upregulated, while miR-486-5p was downregulated in GBM tissues and cell lines, and GBM patients with high expression of CircZNF652 and SERPINE1, and patients with low expression of miR-486-5p tended to have a worse prognosis. Yes . Further results validated that both silencing of circZNF652 and miR-486-5p overexpression suppressed cell growth, migration, invasion, epithelial-mesenchymal transition (EMT) and tumorigenesis in GBM cells in vitro and in vivo. 35258403 Neat1 LncRNA Mus musculus Ventilator-Induced Lung Injury lung tissues of VILI mice and cell stretch (CS) treated AMs Interaction(miR-20b) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//MTT//Luciferase Report Assay//Cell Apoptosis Assay//ELISA//Bioinformatics Analysis The results demonstrated that NEAT1 was highly expressed in lung tissues of VILI mice and cell stretch (CS) treated AMs. Notably, miR‑20b was identified as the target of NEAT1, and STAT3 was the target of miR‑20b. NEAT1 knockdown decreased STAT3 protein expression, the effects of which were reversed following transfection with miR‑20b inhibitor. Furthermore, the protective effect of NEAT1 knockdown on VILI was reversed following transfection with miR‑20b inhibitor. Yes Furthermore, NEAT1 knockdown inhibited lung injury and cell apoptosis induced by VILI. Compared with VILI mice or CS?treated AMs, NEAT1 knockdown accelerated the phenotypic transformation from M1 to M2, and decreased the expression levels of IL?1β, IL?6, TNF?α and iNOS. 34981816 MEG3 LncRNA Homo sapiens Urinary Bladder Neoplasms Bladder Cancer Tissue Interaction[Binds with miR-27a] Western Blot//RIP//qRT-PCR//Luciferase Report Assay//Transwell Assay In the current study, we demonstrated that maternally expressed gene 3 (MEG3) is significantly downregulated in human invasive bladder cancers in comparison to non-invasive bladder cancers, and that ectopic expression of MEG3 dramatically inhibits the invasiveness of human bladder cancer cells.Our mechanistic studies reveal that MEG3, as a ceRNA, inhibits the invasiveness of human bladder cancer cells via negative regulation of c-Myc by competing with PHLPP2 mRNA for miR-27a. Yes In the current study, we demonstrated that maternally expressed gene 3 (MEG3) is significantly downregulated in human invasive bladder cancers in comparison to non-invasive bladder cancers, and that ectopic expression of MEG3 dramatically inhibits the invasiveness of human bladder cancer cells.Consistently, ectopic expression of MEG3 also attenuates metastatic ability of T24T cells, a cell line derived from T24 cells, in the lungs of nude mice. 30826633 circEPB41L2 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma serum samples and tissues Expression(lower expressed) qRT-PCR The results revealed that expression levels of hsa_circ_001010, hsa_circ-ZNF609 were significantly elevated while hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_0072309 were lower in lung adenocarcinoma serum samples and tissues than those in healthy controls (p < 0.05). . Meanwhile, hsa_circ_001010 and hsa_circ-ZNF609 were downregulated hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_0072309 were elevated in A549 cells compared with BEAS-2B cells. Notably, higher expressions of hsa_circ_001010, hsa_circ-ZNF609, and lower expressions of hsa_circ-CRIMI1, hsa_circ-BGT2, hsa_circ-EPB41L2, and hsa_circ_0072309 were positively correlated with clin-ical stage, lymph node metastasis, and smoking. Last but not least, patients with higher expressions of hsa_ circ_001010, hsa_circ-ZNF609, and lower expressions of hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_ 0072309 had significantly lower overall survival rates and disease-free rates as well. Yes Knockdown of hsa_circ-CRIMI1, hsa_circ-EPB41L2, or hsa_circ_0072309 and overexpressing of hsa_circ_001010 and hsa_circ-ZNF609 could promote A549 cell apoptosis but inhibits proliferation as well. 34383411 MEG3 LncRNA Homo sapiens Glioma cell lines Interaction[miR-377 and PTEN] Flow Cytometry//Western Blot//PCR//Transwell Assay MiR-377 mimics increased MEG3 expression and decreased the number of migrated and invaded U118 and U251 cells, without influence on apoptosis in both cell lines. Si-MEG3 decreased U118 cell apoptosis and induced G0/G1 cell cycle arrest, and pc-MEG3 increased U251 cell apoptosis via arresting cell cycle at G2/M phage. MiR-377 mimics and si-MEG3 increased the relative expression level of N-cadherin mRNA, and both si-MEG3 and pc-MEG3 increased E-cadherin in glioma cells. MiR-377 mimics increased ETS-1 mRNA in U118 cells, but decreased it in U251 cells. PTEN was increased by miR-377 mimics and si-MEG3 and decreased by pc-MEG3 in glioma cells. Yes Si-MEG3 transfection increased U118 cell migration and invasion and rescued miR-377 mimics-induced inhibitory in cell migration and invasion. 31378455 NORAD LncRNA Homo sapiens Breast Neoplasms Interaction[YAP pathway ] RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay//ChIP Here, we show that lncRNA NORAD is downregulated in lung and breast cancers, and that NORAD low expression in these cancer types is associated with lymph node metastasis and poor prognosis. Mechanistically, NORAD exploits its multiple repeated sequences to function as a multivalent platform for binding and sequestering S100P, thereby suppressing S100P-elicited pro-metastatic signaling network. Using cell and mouse models, we show that the S100P decoy function of NORAD suppresses lung and breast cancer migration, invasion, and metastasis. Together, our study identifies NORAD as a novel metastasis suppressor, elucidates its regulatory and functional mechanisms, and highlights its prognostic value. Yes Functionally, NORAD elicits potent inhibitory effects on migration and invasion of multiple lung and breast cancer cell lines, and repression of NORAD expression participates in the migration- and invasion-stimulatory effects of the YAP pathway. 30967631 hsa_circ_0018414 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(miR-6807-3p/DKK1 axis-inactivated Wnt/β-catenin pathway.) In Vivo Experiment//IHC//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining We first observed that circ_0018414 was downregulated in LUAD tissues and cells. Also, low expression of circ_0018414 predicted unfavorable prognosis of LUAD patients. Moreover, circ_0018414 overexpression enhanced the expression of its host gene, dickkopf WNT signaling pathway inhibitor 1 (DKK1), therefore inactivating the Wnt/β-catenin pathway. Additionally, circ_0018414 could sponge miR-6807-3p to protect DKK1 mRNA from miR-6807-3p-induced silencing, leading to DKK1 upregulation in LUAD cells. Finally, rescue assays proved that circ_0018414 inhibited the progression of LUAD via the miR-6807-3p/DKK1 axis-inactivated Wnt/β-catenin pathway. low expression of circ_0018414 predicted unfavorable prognosis of LUAD patients. Yes Then, upregulation of circ_0018414 repressed cell proliferation and stemness, while promoting cell apoptosis, in LUAD. 33614229 hsa_circ_0072309 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma serum samples and tissues Expression(lower expressed) qRT-PCR The results revealed that expression levels of hsa_circ_001010, hsa_circ-ZNF609 were significantly elevated while hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_0072309 were lower in lung adenocarcinoma serum samples and tissues than those in healthy controls (p < 0.05). . Meanwhile, hsa_circ_001010 and hsa_circ-ZNF609 were downregulated hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_0072309 were elevated in A549 cells compared with BEAS-2B cells. Notably, higher expressions of hsa_circ_001010, hsa_circ-ZNF609, and lower expressions of hsa_circ-CRIMI1, hsa_circ-BGT2, hsa_circ-EPB41L2, and hsa_circ_0072309 were positively correlated with clin-ical stage, lymph node metastasis, and smoking. Last but not least, patients with higher expressions of hsa_ circ_001010, hsa_circ-ZNF609, and lower expressions of hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_ 0072309 had significantly lower overall survival rates and disease-free rates as well. Yes Knockdown of hsa_circ-CRIMI1, hsa_circ-EPB41L2, or hsa_circ_0072309 and overexpressing of hsa_circ_001010 and hsa_circ-ZNF609 could promote A549 cell apoptosis but inhibits proliferation as well. 34383411 NORAD LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[regulating TGF-β pathway] qRT-PCR//Western Blot Increased expression of lncRNA-NORAD in breast cancer tissues promotes proliferation, invasion and migration of breast cancer cells and correlated with worse prognosis. LncRNA-NORAD activated TGF-β/RUNX2 signaling pathway in breast cancer cells. Yes Increased expression of lncRNA-NORAD in breast cancer tissues promotes proliferation, invasion and migration of breast cancer cells and correlated with worse prognosis. LncRNA-NORAD activated TGF-β/RUNX2 signaling pathway in breast cancer cells. 30930692 Neat1 LncRNA Mus musculus Ischemic Stroke MCAO Expression(highly expressed) In Vivo Experiment//qPCR//H&E Staining//ELISA//IHC We identified six hub lncRNAs (Neat1, Gm10827, Trp53cor1, Mir670hg, C730002L08Rik, and Mir181a-hg) that were highly correlated with activated-microglia mRNAs (cor > 0.8). We found that Neat1 had the highest correlation coefficient with pro-inflammatory factor mRNA levels. Yes In vivo experiments demonstrated that Neat1 had abnormally high expression after MCAO. Knockdown of Neat1 could significantly alleviate brain damage by reducing the number of activated microglia and reducing their release of proinflammatory cytokines. 34188516 NORAD LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction(miR-204-5p/ PTEN/PI3K/AKT signaling) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay NORAD was upregulated in the GC tissues and cell lines. The silencing of NORAD repressed cell proliferation and the Growth 2 (G2)/Mitosis (M) cell-cycle transition in GC. NORAD also regulated KMT2D expression by targeting miR-204-5p and mediated PTEN/PI3K/AKT signaling in GC. Yes The silencing of NORAD repressed cell proliferation and the Growth 2 (G2)/Mitosis (M) cell-cycle transition in GC. NORAD also regulated KMT2D expression by targeting miR-204-5p and mediated PTEN/PI3K/AKT signaling in GC. 36636064 MEG3 LncRNA Homo sapiens Glioma glioma tissue Interaction[miR‑96‑5p/MTSS1 signaling pathway] Northern Blot//Western Blot//CCK8//qRT-PCR//Transwell Assay In the present study, MEG3 was downregulated in glioma tissue. In addition, downregulation of MEG3 was observed in human glioma cell lines compared with normal astrocyte cells.Additionally, microRNA‑96‑5p (miR‑96‑5p) was a promising target of MEG3, and the promoting effects of miR‑96‑5p on cell growth and metastasis could be reversed by upregulated MEG3. Metastasis suppressor 1 (MTSS1) was predicted as the putative target of miR‑96‑5p, and its expression was restored by MEG3. In summary, the present data provided novel insight into the roles of MEG3 in glioma, and MEG3/miR‑96‑5p/MTSS1 signaling could be a promising therapeutic target for the treatment of patients with glioma. Yes Furthermore, overexpressed MEG3 inhibited the proliferation, migration and invasion of glioma cells. 31545491 circPITX1 CircRNA Homo sapiens Glioblastoma cell lines Regulation[miR-379-5p/MAP3K2 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining Herein, circ-PITX1 was found to be upregulated in glioblastoma and could mediate glioblastoma tissues and cell lines. Through mechanism investigation, we identified the cytoplasmic localization of circ-PITX1 and its molecular sponge role. The interactions between circ-PITX1 and miR-379-5p as well as between miR-379-5p and MAP3K2 were demonstrated. Thus, we confirmed that circ-PITX1 exerted as a competing endogenous RNA (ceRNA) in glioblastoma by sponging miR-379-5p to elevate MAP3K2 expression. Rescue assays demonstrated that MAP3K2 rescued the proliferation and apoptosis mediated by the silencing of circ-PITX1. Yes Functionally, downregulation of circ-PITX1 hampered cell proliferation and accelerated cell apoptosis. 31493405 NORAD LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression(highly expressed) qRT-PCR//Wound Healing Assay//MTT//Western Blot NORAD was significantly overexpressed in GC tissues compared to ANTs (P value < 0.0001). Yes NORAD downregulation leads to decreased cell viability (P value < 0.001) and migration (P value < 0.01), increased apoptosis rate (P value < 0.0001), and increased protein level for PTEN, E-cadherin, and Bax, but decreased protein level for Bcl-2. 35083614 MEG3 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction[degradation of P-STAT3] Flow Cytometry//RNA Pull-Down//Colony Formation Assay//RIP RNA pull-down and RIP assays demonstrated that MEG3 bound directly to P-STAT3 protein. CHX-chase and ubiquitination assay results showed that MEG3 promoted P-STAT3 degradation via ubiquitination. Clone formation assay and flow cytometry analysis results revealed that the inhibitory effect of MEG3 on P-STAT3 promoted apoptosis and inhibited proliferation of cervical cancer cells. Yes In vivo tumor formation experiments showed that MEG3 inhibited the tumor formation ability of cervical cancer cells. 31320837 NORAD LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-496/IL-33) In Vivo Experiment//Western Blot//Tunel//qRT-PCR//FISH//IF//Cell Viability Assay//ELISA//IHC//Transwell Assay As exhibited, NORAD was up-regulated in GC tissues and cells, while miR-496 was remarkably down-regulated. . The dual-luciferase reporter assay confirmed that miR-496 was a target of NORAD and targeted IL-33. Yes Overexpressing NORAD substantially promoted the proliferation, migration, invasion, and EMT of GC cells and repressed cell death, while overexpressing miR-496 had the opposite effects. Additionally, NORAD enhanced the IL-33 expression and the release of IL-33 from GC cells. 34895039 NORAD LncRNA Homo sapiens Stomach Neoplasms cell lines Regulation[RhoA/ROCK1 pathway ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay "As shown in Figure 1A, NORAD was upregulated in most GC cells, of which AGS and BGC-823 cells harboured the highest NORAD expression." Yes Results showed that NORAD knockdown decreased cell proliferation, migration and invasion but increased cell apoptosis. 31115002 Neat1 LncRNA Mus musculus Heart Injuries Myocardial Tissues Regulation[TLR2/NF-κB signaling pathway] qRT-PCR//IHC//Tunel//Western Blot " Firstly, the expression level of NEAT1 in mouse heart of three groups was detected by RT-PCR. The results revealed that the expression.TUNEL staining showed that NEAT1 knockdown markedly reduced LPS-induced apoptosis of cardiac cells (p<0.05). Immunohistochemical results revealed that NEAT1 knockdown could remarkably reverse LPS-induced elevation of the myocardial 4-HNE expression and decrease the oxidative stress in the heart (p<0.05). At the same time, CD45+ and CD68+ cells were reduced after NEAT1 knockdown in myocardial tissues (p<0.05). Reverse Transcription-Polymerase Chain Reaction (RT-PCR) showed that the mRNA levels of inflammatory indicators in LPS + NEAT1 siRNA group were lower than that in the LPS group (p<0.05). According to Western blotting results, NEAT1 siRNAs could significantly downregulate the protein expressions of TLR2 and p-p65. level of lncRNA NEAT1 in mouse myocardial tissues of the LPS group was significantly upregulated than that of the Sham group (p<0.05)." Yes ENEAT1 knockdown could significantly improve ischemia/reperfusion (I/R)-induced cardiac insufficiency in rats, and increase EF (%) and FS (%) (p<0.05). Besides, NEAT1 knockdown remarkably inhibited the LPS-induced myocardial injury. 31210324 MEG3 LncRNA Homo sapiens Parkinson Disease PD patients (n = 79) and healthy controls (n = 62) Expression [highly expressed] qRT-PCR//MTT//Western Blot MEG3 was downregulated in PD patients compared to that in the healthy controls. Yes Overexpression of MEG3 increased the expression levels of leucine-rich repeat kinase 2 (LRRK2) in SH-SY5Y cells. In contrast, overexpression of LRRK2 showed no significant effects on MEG3. Overexpression of MEG3 improved the viability and inhibited the apoptosis of SH-SY5Y cells pretreated with MPP + . 34643842 NORAD LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Regulation[miR-214/Akt/mTOR Axis] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining The qRT-PCR results showed that lncRNA NORAD was highly expressed in human GC tissues and cell lines.Meanwhile, there was a direct interaction between lncRNA NORAD and miR-214. NOARD could also inhibit the apoptosis of GC cells by down-regulating caspase-3; however, miR-214 overexpression attenuated this effect. Moreover, lncRNA NORAD promoted the phosphorylation of Akt and mTOR in mouse GC tissues and GC cell lines, while miR-214 mimics inhibited that promotion. Yes lncRNA NORAD could promote the growth and proliferation of GC cells both in vivo and in vitro. 31802897 Neat1 LncRNA Mus musculus Myocardial Reperfusion Injury heart tissues Regulation[MAPK signaling pathway ] qRT-PCR NEAT1 was greatly increased in myocardial IR injury mice models.In summary, our data indicated that NEAT1 contributed to myocardial IR injury via activating the MAPK pathway. Yes knockdown of NEAT1 resulted in attenuated myocardial IR injury in vivo. 30950059 NORAD LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[sponging miR-608] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Here, we found that NORAD was highly expressed in gastric cancer tissues and cell lines.Mechanistically, NORAD acted as a competitive endogenous RNA (ceRNA), which sponged miR-608 and suppressed the expression of miR-608 in gastric cancer cells. Further experiments demonstrated that miR-608 targeted the forkhead box O6 (FOXO6) and negatively regulated the expression of FOXO6. Consistent with the inhibitory effect of NORAD on miR-608, overexpression of NORAD enhanced the level of FOXO6 in gastric cancer cells. Overexpression of FOXO6 attenuated the inhibitory effect of miR-608 on the gastric cancer cell growth. Collectively, our results demonstrated that NORAD promoted the growth of gastric cancer cells via modulating the miR-608/FOXO6 pathway. Yes Down-regulation of NORAD suppressed the proliferation and migration of gastric cancer cells. 30453063 circAKT3 CircRNA Homo sapiens Glioblastoma GBM tissues Interaction[active phosphoinositide-dependent Kinase-1] qRT-PCR//RNA-seq Circ-AKT3 is expressed at low levels in GBM tissues compared with the expression in paired adjacent normal brain tissues. Our data indicate that the impaired circRNA expression of the AKT3 gene contributes to GBM tumorigenesis, and our data corroborate the hypothesis that restoring AKT3-174aa while inhibiting activated AKT may provide more benefits for certain GBM patients. Yes while the knockdown of circ-AKT3 enhanced the malignant phenotypes of astrocytoma cells. 31470874 circPTPRF CircRNA Homo sapiens Glioblastoma GBM tissues and cells Interaction(circPTPRF/miR-1208/YY1 axis ) In Vivo Experiment//Bioinformatics Analysis//Transfection//qRT-PCR//RIP//IF//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay In this study, we found circPTPRF is a novel circRNA that has never been studied, which was highly expressed in GBM and is closely related to poor patient prognoses. Mechanisms, miR-1208 was confirmed as a target of circPTPRF, and miR-1208 can also target the 3'UTR of YY1, and they were proved by luciferase reporter, western blotting (WB), qPCR and RNA immunoprecipitation (RIP) assays. The following rescue experiments demonstrated that circPTPRF was a miR-1208 sponge for upregulating YY1 expression to promote proliferation, invasion and neurosphere formation abilities of GBM in vitro. In this study, we found circPTPRF is a novel circRNA that has never been studied, which was highly expressed in GBM and is closely related to poor patient prognoses. Yes After knockdown or overexpression in glioma cell lines (U87 and LN229) and glioma stem cells (GSCs), we identified that circPTPRF could promote proliferation, invasion, and neurospheres formation abilities of GBM via in vitro and in vivo experiments. 36397164 circZNF609 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma serum samples and tissues Expression(highly expressed) qRT-PCR The results revealed that expression levels of hsa_circ_001010, hsa_circ-ZNF609 were significantly elevated while hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_0072309 were lower in lung adenocarcinoma serum samples and tissues than those in healthy controls (p < 0.05). . Meanwhile, hsa_circ_001010 and hsa_circ-ZNF609 were downregulated hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_0072309 were elevated in A549 cells compared with BEAS-2B cells. Notably, higher expressions of hsa_circ_001010, hsa_circ-ZNF609, and lower expressions of hsa_circ-CRIMI1, hsa_circ-BGT2, hsa_circ-EPB41L2, and hsa_circ_0072309 were positively correlated with clin-ical stage, lymph node metastasis, and smoking. Last but not least, patients with higher expressions of hsa_ circ_001010, hsa_circ-ZNF609, and lower expressions of hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_ 0072309 had significantly lower overall survival rates and disease-free rates as well. Yes Knockdown of hsa_circ-CRIMI1, hsa_circ-EPB41L2, or hsa_circ_0072309 and overexpressing of hsa_circ_001010 and hsa_circ-ZNF609 could promote A549 cell apoptosis but inhibits proliferation as well. 34383411 circPOSTN CircRNA Homo sapiens Glioblastoma 15 pairs of GBM clinical specimens and the normal adjunct tissues Interaction(miR-219a-2-3p/STC1/VEGFA) RNA Pull-Down//IHC//Western Blot//Transfection//Tube Formation Assay//Migration Assay//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In this study, by conducting gene expression detection based on 15 pairs of GBM clinical specimens and the normal adjunct tissues, we observed that circPOSTN showed abnormally higher expression in GBM. CircRNA-miRNA interaction prediction based on online analytical processing, AGO2-RIP assay, biotin labeled RNA pulldown assay, and dual-luciferase reporter assay revealed that circPOSTN sponged miR-219a-2-3p, limited its biological function, and ultimately upregulated their common downstream gene STC1. Finally, by carrying out in vitro and in vivo functional assays, we uncovered a new regulatory axis circPOSTN/miR-219a-2-3p/STC1 that promoted GBM neovascularization by increasing vascular endothelial growth factor A (VEGFA) secretion. Yes Both loss-of-function and gain-of-function biological experiments demonstrated that circPOSTN scheduled the proliferation, migration, and neovascularization abilities of GBM cells. 35927233 NPTN-IT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(miR-93-5p/miR-106b-5p/SOCS4) CCK8//qRT-PCR//Luciferase Report Assay//Western Blot The downregulation of lncRNA-LET is correlated to the poor prognosis of ESCC patients.Finally, the mechanistic views regarding the effects of miR-106b-5p or miR-93-5p and SOCS4 on ESCC are related to the feedback of lncRNA-LET. The downregulation of lncRNA-LET is correlated to the poor prognosis of ESCC patients. Yes Moreover, the upregulated expression of lncRNA-LET could have reduced the cell viability. In vivo tumor inhibition efficacy assays showed that an increase of lncRNA-LET presented excellent inhibitory effects on cancer proliferation as reflected by tumor weight and volume in mice. 35619921 MEG3 LncRNA Homo sapiens Colorectal Neoplasms CRC tumor tissue and cell lines Regulation[regulating miR-376/PRKD1 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay We observed that MEG3 was significantly down-regulated in both CRC tumor tissue and cell lines Yes the transient over-expression of MEG3 in CRC cell line SW480 and LoVo inhibited the proliferation and the migration and clone formation capability of cells; on the other hand, the knockdown of MEG3 has revealed opposite effects. 31632544 hsa_circ_001895 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC and adjacent noncancer tissues Interaction[microRNA-296-5p,SOX12] Western Blot//Wound Healing Assay//CCK8//RIP//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay We first used qRT-PCR analysis to find dysregulated circRNAs in ccRCC. A novel circRNA, hsa_circ_001895, was upregulated in ccRCC specimens and associated with metastatic properties of ccRCC.Mechanistically, hsa_circ_001895 directly binds with microRNA (miR)-296-5p and inhibits its expression. Moreover, sex determining region Y (SRY)-box 12 (SOX12) was identified as a target of miR-296-5p, the expression of which was suppressed by miR-296-5p. Notably, the inhibitory effect of hsa_circ_001895 on ccRCC progression was reversed by miR-296-5p inhibitor. In general, our findings indicated that hsa_circ_001895 may sponge miR-296-5p and promote SOX12 expression, which is the underlying mechanism of hsa_circ_001895-induced ccRCC progression. Yes Additionally, overexpression of hsa_circ_001895 not only promoted cell proliferation, invasion and migration of ccRCC, but also inhibited cell apoptosis, whereas hsa_circ_001895 knockdown reversed the effect on ccRCC progression. In vivo s.c. xenotransplanted tumor model also showed that silencing hsa_circ_001895 could suppress in vivo ccRCC growth. 31782868 hsa_circ_0010117 CircRNA Homo sapiens Glioblastoma glioblastoma tissues and cells Interaction(miRNA-6779-5p/SPEN axis) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay In this study, we found that circ-0010117 is downregulated in glioblastoma compared with corresponding paratumoural tissues. Subsequently, we observed that circ-0010117 can regulate aggressiveness in glioblastoma cells through miR-6779-5p. Furthermore, SPEN was verified as a direct target of miR-6779-5p and contributes to the circ-0010117 regulatory network. Yes In addition, we identified that overexpression of circ-0010117 can suppress tumorigenesis in nude mice. 36087384 MEG3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues regulation[ PSAT1-dependent glycogen synthase kinase-3β/Snail signaling pathway] qRT-PCR//Microarray MEG3 expression level was found to be markedly lower in tumor tissues and cells.Taken together, these results suggest that MEG3 may be a useful prognostic biomarker and may suppress EMT by inhibiting the PSAT1‑dependent glycogen synthase kinase‑3β/Snail signaling pathway in ESCC. Yes Ectopic expression of MEG3 inhibited cell proliferation, migration, invasion and cell cycle progression in EC109 cells. 32901893 MEG3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer cells regulation[MEG3/DKC1 ] CCK8//qRT-PCR//Flow Cytometry//ELISA//Transwell Assay The results demonstrated that lncRNA MEG3 was downregulated, while its binding protein, DKC1, was upregulated in lung cancer cells.LncRNA MEG3/DKC1 was identified as a novel dual-directional regulatory axis in the present study, acting as a promising target for the treatment of lung cancer. Yes Furthermore, lncRNA MEG3 inhibited cell proliferation, migration, invasion and telomerase activity in A549 cells by downregulating DKC1. lncRNA MEG3 inhibited non-small cell lung cancer progression by inhibiting telomere function, cell proliferation, telomerase activity, cell migration and invasion via regulation of the DKC1 protein expression. 32782535 MEG3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and A549 and HCC823 cell lines interaction[microRNA-7-5p] qRT-PCR//Luciferase Report Assay//Western Blot The expressions of lncRNA MEG3 and BRCA1 in NSCLC tissues and A549 and HCC823 cell lines were significantly lower than those in the normal group.LncRNA MEG3 was significantly downregulated in NSCLC, and it could regulate the BRCA1 expression by competitive binding to microRNA-7-5p. Yes Overexpression of lncRNA MEG3 and BRCA1 in A549 and HCC823 cell lines resulted in increased apoptosis of lung cancer cells. 30280775 MIAT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-214 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Invasion Assay//ChIP The H3/H4 histone acetylation level of MIAT promoter in HCC tissues was higher than that in normal tissues. MIAT negatively regulated miR-214 in HCC cells. Inhibition of miR-214 reversed the influence of MIAT downregulation on HCC cell proliferation and invasion.In nude mouse xenograft models, downregulation of MIAT markedly suppressed the tumor growth of HCC via releasing miR-214. Yes Upregulation of MIAT is related to the proliferation and invasion of HCC, and downregulating MIAT expression inhibited HCC cell proliferation and invasion. 29097358 MIAT LncRNA Homo sapiens Carotid Artery Diseases Interaction(KLF4 ) ISH//Transfection//Immunoblotting//Migration Assay//RIP//Cell Apoptosis Assay//Cell Proliferation Assay//IHC//IF MIAT mechanistically regulated SMC proliferation through the EGR1 (Early Growth Response 1)-ELK1 (ETS Transcription Factor ELK1)-ERK (Extracellular Signal-Regulated Kinase) pathway. MIAT is further involved in SMC phenotypic transition to proinflammatory macrophage-like cells through binding to the promoter region of KLF4 and enhancing its transcription. Yes Experimental knockdown of MIAT, using site-specific antisense oligonucleotides (LNA-GapmeRs) not only markedly decreased proliferation and migration rates of cultured human carotid artery smooth muscle cells (SMCs) but also increased their apoptosis. Studies using Miat-/- and Miat-/-ApoE-/- mice, and Yucatan LDLR-/- mini-pigs, as well, confirmed the regulatory role of this lncRNA in SMC de- and transdifferentiation and advanced atherosclerotic lesion formation. 34647815 MEG3 LncRNA Homo sapiens Breast Neoplasms breast cancer cells Interaction( miR-146b-5p ) RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay Herein, we demonstrated that MEG3 was downregulated in pan-cancers and correlated with SLFN5 expression positively in breast cancer by bioinformatics analysis of TCGA and UCSC Xena data. Through bioinformatics analysis of starBase and LncBase data, 12 miRNAs were found to regulate both SLFN5 and MEG3, in which miR-146b-5p was confirmed to be regulated by MEG3 using MEG3 siRNA and overexpression method. Yes MEG3 repressed EMT and migration/invasion, similar to our previously reported functions of SLFN5 in breast cancer. 36033389 NDRG1 LncRNA Homo sapiens Osteosarcoma osteosarcoma cell lines and tissues Interaction( miR-96-5p/ PI3K/AKT) qRT-PCR//IHC LncRNA NDRG1 was up-regulated in osteosarcoma cell lines and tissues and the expression of LncRNA NDRG1 was correlated with the overall survival of osteosarcoma patients.Mechanistically, LncRNA NDRG1 was found to aggravate osteosarcoma progression and regulate the PI3K/AKT pathway by sponging miR-96-5p. LncRNA NDRG1 was up-regulated in osteosarcoma cell lines and tissues and the expression of LncRNA NDRG1 was correlated with the overall survival of osteosarcoma patients. Yes Functional experiments exhibited that LncRNA NDRG1 aggravated osteosarcoma proliferation and migration in vitro; meanwhile, animals experiments showed that LncRNA NDRG1 promoted osteosarcoma growth and metastasis in vivo. 35787258 MEG3 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Regulation(DNMT1-mediated MEG3/Notch1) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Colony Formation Assay In this study, we discovered that MEG3 was downregulated by CpG hypermethylation within its gene promoter.Functionally, treatment of breast cancer cells with the DNA methylation inhibitor 5-AzadC as well as silencing of DNA methyltransferase-1 (DNMT1) could decrease the abnormal hypermethylation of the MEG3 promoter, reverse MEG3 expression, inhibit cell proliferation and promote cell apoptosis. In addition, we found that MEG3 expression was negatively correlated with DNMT1. Mechanistically, MEG3 knockdown combined with 5-AzadC or sh-DNMT1 treatment restored the expression of Notch1 receptor, leading to the Notch1 pathway activation, and promoted the progression of epithelial mesenchymal transformation (EMT). Finally, the mice tumor model experiments showed that DNMT1 knockdown can increase MEG3 expression and inhibit tumor growth. Yes Functionally, treatment of breast cancer cells with the DNA methylation inhibitor 5-AzadC as well as silencing of DNA methyltransferase-1 (DNMT1) could decrease the abnormal hypermethylation of the MEG3 promoter, reverse MEG3 expression, inhibit cell proliferation and promote cell apoptosis. 35822955 MTO1 CircRNA Homo sapiens Stomach Neoplasms gastric tumor tissue Expression(lower expressed) Transfection Circ-MTO1 was insufficiently expressed in gastric tumor tissue (median (interquartile range): 0.403 (0.288-0.518)) compared with adjacent tissue (median (interquartile range): 1.000 (0.715-1.524)) (p < 0.001). Besides, tumor circ-MTO1 was correlated with less lymph node metastasis (p = 0.014) and low TNM stage (p = 0.039), while was not correlated with demographic features or other clinical characteristics (all p > 0.05). Furthermore, tumor circ-MTO1 high expression was independently correlated with prolonged disease-free survival (DFS) (p = 0.013, adjusted hazard ratio (95% confidential interval): 0.314 (0.126-0.782)), but was not correlated with overall survival (p > 0.05). Yes Lastly, in gastric cancer cells, OE-circ-MTO1 apparently decreased relative cell viabilities at oxaliplatin concentrations of 0.4, 0.8, 1.6, and 3.2 μM (all p < 0.05). 35478417 circKEAP1 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction(miR-141-3p/KEAP1/NRF2 Axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//MTT//migration assay//Cell Proliferation Assay We found circKEAP1 was significantly downregulated in LUAD tissues and repressed tumor growth both in vitro and in vivo. Mechanistically, circKEAP1 competitively binds to miR-141-3p and relive miR-141-3p repression for its host gene, which activated the KEAP1/NRF2 signal pathway, and finally suppresses the tumor progress. Yes We found circKEAP1 was significantly downregulated in LUAD tissues and repressed tumor growth both in vitro and in vivo. 34136401 hsa_circ_0004296 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues, blood, and urine Interaction(EIF4A3/ETS1 ) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//IF//RNA-seq//Transwell Assay The expression of circ_0004296 was decreased in PCa tissues, blood, and urine, which was negatively associated with metastasis. Mechanistically, circ_0004296 regulated host gene ETS1 expression at the post-transcriptional level. EIF4A3 was identified and confirmed as the downstream binding protein of circ_0004296. The expression of circ_0004296 was decreased in PCa tissues, blood, and urine, which was negatively associated with metastasis. Yes Furthermore, gain and loss of function experiments in vitro and in vivo showed that circ_0004296 inhibited the proliferation, migration, invasion, and epithelial-mesenchymal transition of PCa cells 34696782 ncRuPAR LncRNA Homo sapiens Stomach Neoplasms gastric cancer cell Regulation(PAR-1, PI3K/Akt signaling, and cyclin D1. ) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Microarray//Colony Formation Assay//Invasion Assay//Transwell Assay Overexpression of ncRuPAR in vitro was found to inhibit its known target PAR-1, as well as PI3K/Akt signaling. The downstream targets of PI3K/Akt, cyclin D1 was downregulated, but there was no change in expression level of B-cell lymphoma 2 (Bcl-2). Yes ncRuPAR inhibited human gastric cancer cell proliferation and induced G1/S phase arrest and apoptosis, but did not affect migration or invasion in vitro. 36438913 NR038975 LncRNA Homo sapiens Stomach Neoplasms serum exosomes and serum of GC patients Interaction(NF90/NF45 Complex) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//IP//Colony Formation Assay//Invasion Assay Our data demonstrated that upregulated NR038975 expression was significantly related to lymph node metastasis and TNM stage. We further demonstrated that genetic deficiency of NR038975 abrogated the interaction between NF45 and NF90. Moreover, NF90 increased the stability of NR038975. Thus, NR038975-NF90/NF45 will be an important combinational target of GC. Our data demonstrated that upregulated NR038975 expression was significantly related to lymph node metastasis and TNM stage. Yes In addition, knockdown of NR038975 inhibited GC cell proliferation, migration, invasion, and clonogenicity and vice versa. 34900675 circEIF6 CircRNA Homo sapiens Pancreatic Neoplasms pancreatic tumor tissues and cell lines Interaction( miR-557/ SLC7A11/PI3K/AKT Signaling) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Invasion Assay//Transwell Assay CircEIF6 abundance was aberrantly up-regulated in pancreatic tumor tissues and cell lines. SLC7A11 was a target of miR-557, and miR-557 overexpression suppressed malignant potential of pancreatic cancer cells partly through reducing the expression of SLC7A11.CircEIF6 silencing also hampered the activation of phosphatidylinositol 3-kinase (PI3K)/AKT serine/threonine kinase (AKT) pathway. CircEIF6 bound to miR-557, and circEIF6 silencing elevated the expression of miR-557 in pancreatic cancer cells. Yes Cell proliferation, migration and invasion were significantly restrained while cell apoptosis was induced with the silencing of circEIF6 in pancreatic cancer cells.MiR-557 knockdown partly overturned circEIF6 silencing-induced effects in pancreatic cancer cells. 33469368 MEG3 LncRNA Homo sapiens Breast Neoplasms BC tissues Interaction(miR-141-3p/RBMS3 axis) IHC//Western Blot//Tunel//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay By performing in vivo and in vitro experiments, we found that MEG3 and RBMS3 were low-expressed, negatively correlated with high-expressed miR-141-3p, were positively correlated with each other in BC. MEG3 targeted miR-141-3p, and miR-141-3p targeted RBMS3. MEG3, which was mainly distributed in BC cytoplasm, could down-regulate miR-141-3p and up-regulate RBMS3, and reverse effect of miR-141-3p on related gene expressions and on promoting cancer development. Yes Overexpressed MEG3 inhibited growth of xenografts, promoted cell apoptosis via regulating apoptosis related factors, and up-regulated RBMS3 expression but down-regulated miR-141-3p. 33845141 circPVT1 CircRNA Homo sapiens Adenocarcinoma of Lung lung ADC cells Interaction(miR-429/FOXK1 signaling axis) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of circ-PVT1 was found to be increased in lung ADC cells, and shRNA-circ-PVT1 led to decreased cell viability, proliferation, migration and invasion. In conclusion, interference of circ‑PVT1 inhibits the progression of lung ADC and enhances its sensitivity to DDP via miR‑429/FOXK1, which may provide a theoretical basis for the use of novel targets in the treatment of lung ADC. Yes The expression of circ?PVT1 was found to be increased in lung ADC cells, and shRNA?circ?PVT1 led to decreased cell viability, proliferation, migration and invasion. 34328193 circAKT3 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and matched para-carcinoma normal tissues Interaction[binding miR-296-3p ] Western Blot//RIP//Luciferase Report Assay//Microarray//Transwell Assay Circ-AKT3 was verified significantly downregulated in ccRCC.Circ-AKT3 suppresses ccRCC metastasis by enforcing E-cadherin expression through competitively binding miR-296-3p. Yes Knockdown of circ-AKT3 promoted ccRCC migration and invasion, while overexpression of circ-AKT3 suppressed ccRCC metastasis. 31672157 circPOLR2A CircRNA Homo sapiens Glioblastoma GBM cells Interaction(miR-2113/POU3F2 axis/SOX9 ) RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining//ChIP According to experimental results, circPOLR2A was up-regulated in GBM cells and promoted GBM cell proliferation while inhibiting GBM cell apoptosis. CircPOLR2A mainly existed in cell cytoplasm and sponged miR-2113 to positively regulate POU3F2 expression. POU3F2 activated the transcription of SOX9 through interacting with SOX9 promoter (1-500). Rescue assays validated that circPOLR2A influenced GBM cell proliferation and apoptosis via SOX9. To conclude, circPOLR2A enhanced the transcription of SOX9 through miR-2113/POU3F2 axis, thus exacerbating GBM cells growth. Yes According to experimental results, circPOLR2A was up-regulated in GBM cells and promoted GBM cell proliferation while inhibiting GBM cell apoptosis. 35398178 MEG3 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells regulation[miR-30e-3p,LAMA4 ] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot Research results proved that miR-30e-3p was markedly upregulated, while MEG3 and LAMA4 were noticeably downregulated in OC tissues and cells. However, the upregulation of MEG3 increased the expression of LAMA4 by sponging miR-30e-3p, which alleviated the malignancy of OC cells. Yes The overexpression of LAMA4 significantly impaired the proliferation, migration, and invasion of OC cells. 32489317 hsa_circ_01844 CircRNA Homo sapiens Glioblastoma glioblastoma tissues Expression[lower expressed] Flow Cytometry//qRT-PCR//Transwell Assay The expression of circular RNA hsa_circ_01844 was lower in glioblastoma tissues when compared with the normal brain tissues by RT-PCR method (0.034 ± 0.036 vs. 1.630 ± 0.891, P < 0.001). Yes Using two glioblastoma cell lines, we found that overexpression of hsa_circ_01844 in glioblastoma cells suppressed their proliferation, colony formation, migration, and increased the apoptotic rate compared with empty vector group and blank control group (all P < 0.05). 32804726 hsa_circ_001010 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma serum samples and tissues Expression(highly expressed) qRT-PCR The results revealed that expression levels of hsa_circ_001010, hsa_circ-ZNF609 were significantly elevated while hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_0072309 were lower in lung adenocarcinoma serum samples and tissues than those in healthy controls (p < 0.05). . Meanwhile, hsa_circ_001010 and hsa_circ-ZNF609 were downregulated hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_0072309 were elevated in A549 cells compared with BEAS-2B cells. Notably, higher expressions of hsa_circ_001010, hsa_circ-ZNF609, and lower expressions of hsa_circ-CRIMI1, hsa_circ-BGT2, hsa_circ-EPB41L2, and hsa_circ_0072309 were positively correlated with clin-ical stage, lymph node metastasis, and smoking. Last but not least, patients with higher expressions of hsa_ circ_001010, hsa_circ-ZNF609, and lower expressions of hsa_circ-CRIMI1, hsa_circ-EPB41L2, and hsa_circ_ 0072309 had significantly lower overall survival rates and disease-free rates as well. Yes Knockdown of hsa_circ-CRIMI1, hsa_circ-EPB41L2, or hsa_circ_0072309 and overexpressing of hsa_circ_001010 and hsa_circ-ZNF609 could promote A549 cell apoptosis but inhibits proliferation as well. 34383411 hsa_circ_0008274 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction(miR-578/HMGA2) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//cell invasion assay//Colony Formation Assay Our findings determined that the expression of hsa_circ_0008274 in LUAD was significantly decreased.In summary, our data show that the overexpression of hsa_circ_0008274 repressed the proliferation and invasion of LUAD through downregulating miR-578 and activating HMGA2. Yes Cell experiments showed that overexpressed hsa_circ_0008274 could reduce the proliferation and invasion ability of LUAD cells. 34236145 hsa_circ_0002483 CircRNA Homo sapiens Adenocarcinoma of Lung LUAC tissue sample Interaction(miR-125a-3p) In Vivo Experiment//IHC//Western Blot//Transfection//Invasion Assay//FISH//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay We found that circ_0002483 was upregulated in LUAC tissue samples and associated with Tumor Node Metastasis (TNM) stage and poor survival in patients with LUAC. We found that circ_0002483 was upregulated in LUAC tissue samples and associated with Tumor Node Metastasis (TNM) stage and poor survival in patients with LUAC. Furthermore, circ_0002483 sponged miR-125a-3p and negatively regulated its expression. CCL4 was identified as a direct target of miR-125a-3p. The rescue experiments showed that miR-125a-3p mimics reversed the tumor-promoting effects of circ_0002483 by targeting CCL4-CCR5 axis in A549 and PC9 cells. Yes Knockdown of circ_0002483 inhibited proliferation, colony formation and invasion of A549 and PC9 cells in vitro, whereas overexpression of circ_0002483 harbored the opposite effects.In addition, the in vivo experiment further validated that knockdown of circ_0002483 repressed tumor growth. 34641879 circAASDH CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(miR-140-3p/E2F7) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis By screening for differentially expressed circRNAs, we found that circ-AASDH was highly expressed in LUAD tissues and cells and correlated with tumor size, clinical stage and poor prognosis. In mechanism, circ-AASDH could be used as a sponge of miR-140-3p to weaken its inhibition on the expression of E2F7. Additionally, the overexpression of circ-AASDH could deduce the suppression of miR-140-3p on the malignant progression of LUAD cells. Besides, silencing of circ-AASDH inhibited cell proliferation and migration by regulating the expression of E2F7. By screening for differentially expressed circRNAs, we found that circ-AASDH was highly expressed in LUAD tissues and cells and correlated with tumor size, clinical stage and poor prognosis. Yes Transfection of si-circ-AASDH can inhibit the proliferation and migration of LUAD cells and promote apoptosis in vitro. Furthermore, overexpression of circ-AASDH can promote the growth of LUAD in vivo. 33569293 MEG3 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues and cell lines interaction[ sponging miR-205-5p] qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay MEG3 was significantly down-regulated, while miR-205-5p was up-regulated in ovarian cancer tissues and cell lines.The overexpression of lncRNA MEG3 inhibits cell proliferation and cell invasion and promotes apoptosis in ovarian cancer by sponging miR-205-5p. Yes The overexpression of MEG3 and the knockdown of miR-205-5p inhibited cell viability, migration and invasion but promoted the apoptosis rate in ovarian cancer cells. 32509057 circMTO1 CircRNA Homo sapiens Glioblastoma glioblastoma tissues Regulation[miR-92/WWOX Signaling Pathway ] CCK8//qRT-PCR//Colony Formation Assay We showed that circMTO1 was markedly downregulated in glioblastoma tissues compared with adjacent normal tissues.Our results demonstrate that circMTO1 inhibits the proliferation of glioblastoma cells via the miR-92/WWOX signaling pathway. Lower circMTO1 level was significantly associated with shorter overall survival among patients with glioblastoma. Yes In addition, circMTO1 inhibited proliferation of cell U251 cells. 31456594 hsa_circ_0043278 CircRNA Homo sapiens Glioblastoma GMB cell lines and tissues regulation[ circ-0043278/miRNA-638/ Homeobox A9 (HOXA9) axis ] qRT-PCR//Luciferase Report Assay This work validated that circ_0043278 is highly expressed in GMB cell lines and tissues, while knockdown circ_0043278 inhibited GBM cell migration, proliferation, and invasion invitro and tumorigenesis invivo.These results showed that circ-0043278/miRNA-638/ Homeobox A9 (HOXA9) axis had a vital function in promoting GBM progression. Yes This work validated that circ_0043278 is highly expressed in GMB cell lines and tissues, while knockdown circ_0043278 inhibited GBM cell migration, proliferation, and invasion invitro and tumorigenesis invivo. 33154193 MEG3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell line Interaction(miR-5195-3p/FOXO1) CCK8//qRT-PCR//Transwell Assay Compared with normal tissues, MEG3 expression was significantly downregulated in HCC tissues. Double luciferase reporter and RNA pull-down assays confirmed the binding between MEG3 and miR-5195-3p as well as between miR-5195-3p and FOXO1. RT-qPCR and Western blotting results showed that MEG3 inhibited the expression of miR-5195-3p and promoted that of FOXO1. Additionally, MEG3 overexpression inhibited HCC tumorigenesis and progression in xenograft tumor models while depletion of MEG3 exerted the opposite way. Yes MEG3 overexpression inhibited the viability and migration of HCC cells. 34895065 circANXA7 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(miR-331/LAD1 axis) In Vivo Experiment//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Microarray//Colony Formation Assay//EdU Staining//Transwell Assay circ-ANXA7 was up-regulated in LUAD tissues and cells. Furthermore, circ-ANXA7 could accelerate proliferation and invasion of LUAD cells by targeting miR-331. miR-331 directly bound to the 3'-UTR of LAD1. LAD1 induced proliferation and invasion of LUAD cells, which was reversed after co-transfection with circ-ANXA7 knockdown. High circ-ANXA7 expression usually predicted a poorer prognosis for LUAD patients. Yes Its high expression promoted proliferation, migration, and invasion of LUAD cells as well as tumor growth. 33536022 MEG3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell Interaction(miR-9-5p/MDK axis ) CCK8//qRT-PCR//Western Blot The present study demonstrated that MEG3 suppressed HCC cell viability and migration, and induced cell apoptosis. In addition, it was also found that MEG3 targets the miR-9-5p/MDK axis and modulates the PDK/AKT pathway in HCC. Yes In conclusion, the findings of the present study demonstrated that lncRNA MEG3 affects HCC cell viability, apoptosis and migration through its targeting of miR-9-5p/MDK and regulation of the PDK/AKT pathway. 33747202 MEG3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction[sponging miR-9-5p to upregulate SOX11] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Western Blot The results showed that MEG3 and SOX11 were poorly expressed but miR-9-5p was highly expressed in HCC. The results showed that MEG3 and SOX11 were poorly expressed but miR-9-5p was highly expressed in HCC. The expression levels of these molecules suggested a negative correlation between MEG3 and miR-9-5p and a positive correlation with SOX11, confirmed by Pearson's correlation analysis and biology experiments. Furthermore, MEG3 could combine with miR-9-5p, and SOX11 was a direct target of miR-9-5p. Moreover, MEG3 over-expression promoted cell apoptosis and growth inhibition in HCC cells through sponging miR-9-5p to up-regulate SOX11. Therefore, the interactions among MEG3, miR-9-5p, and SOX11 might offer a novel insight for understanding HCC pathogeny and provide potential diagnostic markers and therapeutic targets for HCC. Yes Moreover, MEG3 over-expression promoted cell apoptosis and growth inhibition in HCC cells through sponging miR-9-5p to up-regulate SOX11. 31531526 MEG3 LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues Interaction[upregulating TGF-β1] CCK8//qRT-PCR//Transwell Assay The results showed that expression level of MEG3 was significantly lower in tumor tissues than in adjacent healthy tissues.We also found that MEG3 small interfering Ribonucleic Acid (siRNA) silencing promoted the proliferation, migration, and invasion of hepatocellular carcinoma cells by CCK-8 assay, transwell migration, and invasion assay, respectively, while TGF-β inhibitor treatment reduced those enhancing effects. MEG3 siRNA silencing also increased the expression level of TGF-β1. These results indicated that downregulation of MEG3 can promote proliferation, migration, and invasion of human hepatocellular carcinoma cells by upregulating TGF-β1 expression. Yes We also found that MEG3 small interfering Ribonucleic Acid (siRNA) silencing promoted the proliferation, migration, and invasion of hepatocellular carcinoma cells by CCK-8 assay, transwell migration, and invasion assay, respectively, while TGF-β inhibitor treatment reduced those enhancing effects. 31089680 NDRG1-OT1 LncRNA Homo sapiens Breast Neoplasms In vitro and in vivo functional assays showed that NDRG1-OT1 could promote tumor growth and migration. Interaction(miR-875-3p) Western Blot//Transwell Assay//Wound Healing Assay//qRT-PCR//RIP//IF//MTT//Colony Formation Assay//Invasion Assay//ChIP Expression profiling of NDRG1-OT1 revealed that it was upregulated under hypoxia in different breast cancer cells.Overexpression and knockdown of HIF-1α up- and downregulated NDRG1-OT1, respectively. Luciferase reporter assays and chromatin immunoprecipitation assays validated that HIF-1α transcriptionally activated NDRG1-OT1 by binding to its promoter (-1773 to -1769 and -647 to -643 bp). Next, to investigate whether NDRG1-OT1 could function as a miRNA sponge, results of in silico analysis, expression profiling of predicted miRNAs, and RNA immunoprecipitation assays indicated that NDRG1-OT1 could act as a miRNA sponge of miR-875-3p. Yes In vitro and in vivo functional assays showed that NDRG1-OT1 could promote tumor growth and migration. 36127332 MEG3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[PTEN/AKT/MMP-2/MMP-9 signaling axis] qRT-PCR//Luciferase Report Assay//Western Blot Compared to carcinoma-adjacent regions, MEG3 expression was downregulated in cancer regions of HCC samples; by contrast, miRNA-10a-5p was overexpressed in cancer regions compared to tumor-adjacent areas.Furthermore, miRNA-10a-5p bound the 3-untranslated region of PTEN mRNA and downregulated PTEN protein expression. Taken together, these data suggest that MEG3 regulates the PTEN/AKT/MMP-2/MMP-9 signaling axis and contributes to HCC development by targeting miRNA-10a-5p. Yes Furthermore, overexpression of MEG3 (a) decreased proliferation, migration, and invasion of HepG2 cells; (b) enhanced apoptosis and the proportion of HepG2 cells in G1 of the cell cycle 31396320 MEG3 LncRNA Homo sapiens Osteoarthritis chondrocytes Interaction(miR-93/TGFBR2 Axis) Western Blot//qRT-PCR//MTT//Cell Apoptosis Assay//EdU Staining//IF MEG3 was significantly downregulated in chondrocytes treated with IL-1β, whereas miR-93 was upregulated concomitantly. In addition, MEG3 was found to relieve the inhibitive expression of TGFBR2 as a competitive endogenous RNA (ceRNA) of miR-93, and then activated transforming growth factor-β (TGF-β) signaling pathway, regulated chondrocytes ECM degradation in IL-1β induced chondrocytes subsequently. Yes Overexpression of MEG3 induced the proliferation, suppressed the apoptosis, and relieved the degradation of ECM in IL-1β-induced chondrocytes. knockdown of MEG3 suppressed the proliferation, promoted the apoptosis, and aggravated ECM degradation in IL-1β induced chondrocytes. 31253047 NPSR1-AS1 LncRNA Homo sapiens Thyroid Neoplasms TC cells Interaction(NPSR1) Western Blot//Transfection//qRT-PCR//RIP//Colony Formation Assay//EdU Staining//Transwell Assay In short, NPSR1-AS1 displayed high expression TC cells, and NPSR1-AS1 silence inhibited TC cell malignant behaviors. Additionally, NPSR1-AS1 positively regulated its nearby gene neuropeptide S receptor 1 (NPSR1). ELAV like RNA binding protein 1 (ELAVL1) served as the RNA-binding protein (RBP) to combine with NPSR1-AS1 and NPSR1. Silencing of ELAVL1 reduced the stability of NPSR1 mRNA. Moreover, NPSR1 could activate the mitogen-activated protein kinases (MAPK) pathway in TC cells. Yes Additionally, NPSR1-AS1 positively regulated its nearby gene neuropeptide S receptor 1 (NPSR1). ELAV like RNA binding protein 1 (ELAVL1) served as the RNA-binding protein (RBP) to combine with NPSR1-AS1 and NPSR1. 35030041 NPSR1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[MAPK/ERK pathway] CCK8//qRT-PCR//Western Blot NPSR1-AS1 expression was upregulated in HCC tissues and cell lines.In conclusion, hypoxia-inducible NPSR1-AS1 promotes the proliferation and glycolysis of HCC cells, possibly by regulating the MAPK/ERK pathway, suggesting an underlying therapeutic strategy for HCC. Yes Next, the ectopic expression of NPSR1-AS1 facilitated the proliferation and glycolysis of HCC cells. In contrast, NPSR1-AS1 silencing repressed HCC cell proliferation and glycolysis. 33008585 circASPM CircRNA Homo sapiens Glioblastoma GSC tissues and cells Interaction(miR-130b-3p/E2F1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//IHC//Bioinformatics Analysis//IF CircASPM was overexpressed in GBM and promoted the tumorigenesis and proliferation of GSCs both in vitro and in vivo. Mechanistically, circASPM up-regulated the expression of E2F1 in GSCs via miR-130b-3p sponging. We furtherly demonstrated that circAPSM could promote the GSCs proliferation via E2F1 up-regulating. Yes CircASPM was overexpressed in GBM and promoted the tumorigenesis and proliferation of GSCs both in vitro and in vivo. 35371308 NR2F2-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer cells Interaction(miR-320b/PDCD4 pathway) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay In the current study, we found that NR2F2-AS1 was weakly expressed in gastric cancer cells in comparison with normal cells. Subsequently, our results confirmed that miR-320b was negatively regulated and that suppression of miR-320b alleviated the malignant behaviors of GC cells. More importantly, PDCD4 was a target of miR-320b. Mechanistically, NR2F2-AS1 modulated the expression level of PDCD4 by sponging miR-320b. Yes The study has further disclosed that ectopic of NR2F2-AS1 repressed cell proliferation, migration, invasion and EMT whereas it promoted cell apoptosis in gastric carcinoma. 35048354 MYLK CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[sponging miR-362-3p] qRT-PCR//Western Blot//PCR//IF CircMYLK was highly expressed in HCC tissues and cell lines, which was associated with poor prognosis in HCC patients. MiR-362-3p was a direct target of circMYLK, and Rab23 was a direct target gene of miR-362-3p. Meanwhile, circMYLK was negatively correlated with the expression of miR-362-3p and positively correlated with Rab23 expression. Moreover, either overexpressed miR-362-3p or silencing Rab23 could observably sExpression[Expression[up-expression]-expression]press the enhanced proliferation, invasion, and migration induced by circMYLK in Huh7 and Hep3B cells. Finally, knockExpression[down-expression] of circMYLK and overexpressed miR-362-3p could sExpression[Expression[up-expression]-expression]press the expression of Rab23, thus inhibiting the growth and proliferation of Hep3B cells in vivo. Yes In addition, knockExpression[down-expression] of circMYLK remarkably inhibited the proliferation, invasion, and migration of Huh7 and Hep3B cells. 31413665 circENTPD7 CircRNA Homo sapiens Glioblastoma glioblastoma tissues interaction[targeting ROS1] RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Microarray circENTPD7 (hsa_circ_0019421) was upregulated in glioblastoma tissues. Taken together, these findings indicate that circRNA circENTPD7 promotes glioblastoma cell proliferation and motility by regulating miR-101-3p/ROS1. Kaplan-Meier survival analysis indicated that glioblastoma patients had a poor overall survival when circENTPD7 expression levels were high. Yes Knockdown of circENTPD7 inhibited the motility and proliferation of glioblastoma cells. 32308563 Oip5-as1 LncRNA Rattus norvegicus Lung Injury sepsis models elicited by CLP or LPS Interaction(miR-128-3p/Sirtuin-1 pathway) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//H&E Staining//ELISA//IHC We discovered that OIP5-AS1 and Sirtuin1 (SIRT1) were markedly down-regulated in sepsis models elicited by CLP or LPS, while miR-128-3p experienced a dramatic up-regulation. Mechanistically, miR-128-3p, which targeted SIRT1, was hobbled by OIP5-AS1. Yes OIP5-AS1 overexpression attenuated NR8383 and RLE-6TN cell apoptosis triggered by LPS and suppressed the expressions of nuclear factor kappa B (NF-κB), inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in NR8383 and RLE-6TN cells, whereas miR-128-3p overexpression resulted in the opposite phenomenon. 34592882 OIP5-AS1 LncRNA Mus musculus Heart Failure mice model Regulation In Vivo Experiment//qPCR//RNA-seq Using a series of in vitro and ex vivo methods, we demonstrate that OIP5-AS1 is regulated during cardiac development in rodent and human models and in disease settings in mice. Yes Using CRISPR, we engineered a global OIP5-AS1 knockout (KO) mouse and demonstrated that female KO mice develop exacerbated heart failure following cardiac pressure overload (transverse aortic constriction [TAC]) but male mice do not 34142046 OIP5-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma EC cell Regulation(GPX4) Western Blot//Transfection//CCK8//qRT-PCR//RIP//Flow Cytometry//Colony Formation Assay OIP5-AS1 inhibition significantly inhibited EC cell viability and proliferation, induced ferroptosis, and downregulated GPX4 levels, while GPX4 reversed these effects. OIP5-AS1/GPX4 induced CD8+ T cell interaction and induced apoptosis through PD-1/PD-L1 immune checkpoints of CD8+ T cells. Yes OIP5-AS1 inhibition significantly inhibited EC cell viability and proliferation, induced ferroptosis, and downregulated GPX4 levels, while GPX4 reversed these effects. OIP5-AS1/GPX4 induced CD8+ T cell interaction and induced apoptosis through PD-1/PD-L1 immune checkpoints of CD8+ T cells. 35872956 hsa_circ_400027 LncRNA Homo sapiens Adenocarcinoma of Lung LAD tissues and cell lines Regulation[miR-933/SMAD4 axis ] IHC//Western Blot//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay In the present study, we first found that TP73-AS1 expression was markedly increased in LAD tissues and cell lines and its overexpression was strongly associated with poor clinical outcomes. Then the loss/gain-of-function assays elucidated that TP73-AS1 contributed to cell proliferation, migration, and invasion in vitro, and the in vivo experiments illustrated that its knockdown inhibited tumor growth and metastasis. Yes Then the loss/gain-of-function assays elucidated that TP73-AS1 contributed to cell proliferation, migration, and invasion in vitro, and the in vivo experiments illustrated that its knockdown inhibited tumor growth and metastasis. 30541897 NAMPT-AS LncRNA Homo sapiens Triple Negative Breast Neoplasms Breast tissues Expression[highly expressed] IF//qPCR//IHC//Western Blot In this study, we utilized the The Cancer Genome Atlas (TCGA) database and analyzed clinical samples to show that the long noncoding antisense transcript of nicotinamide phosphoribosyltransferase (NAMPT), NAMPT-AS, is upregulated in TNBC and is associated with poor prognosis, lymph node involvement, metastasis, and advanced stage. In this study, we utilized the The Cancer Genome Atlas (TCGA) database and analyzed clinical samples to show that the long noncoding antisense transcript of nicotinamide phosphoribosyltransferase (NAMPT), NAMPT-AS, is upregulated in TNBC and is associated with poor prognosis, lymph node involvement, metastasis, and advanced stage. Yes NAMPT-AS/NAMPT promoted tumor progression and regulated autophagy through the mTOR pathway in vitro and in vivo. 30940661 OIP5-AS1 LncRNA Homo sapiens Myasthenia Gravis patients with MG, Jurkat cell Interaction(miR-181c-5p/IL-7) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay The expression of OIP5-AS1 was up-regulated in patients with MG. Luciferase reporter assay indicated that OIP5-AS1 targeted the miR-181c-5p. Mechanistically, knockdown of OIP5-AS1 inhibited IL-7 expression at both the mRNA and protein levels in Jurkat cells, whereas the miR-181c-5p inhibitor blocked the reduction of IL-7 expression induced by OIP5-AS1 suppression. Yes Functional assays showed that OIP5-AS1 suppressed Jurkat cell apoptosis and promoted cell proliferation by sponging miR-181c-5p. 35602889 OIP5-AS1 LncRNA Homo sapiens Periodontitis human periodontal ligament stem cells (hPDLSCs) Interaction(miR-92a-3p) Western Blot//Transfection//qRT-PCR//RIP//MTT//Luciferase Report Assay We found that OIP5-AS1 was expressed at low levels in lipopolysaccharide (LPS)-stimulated hPDLSCs. OIP5-AS1 overexpression promoted proliferation and osteogenic differentiation ability and reduced LPS-induced inflammation in hPDLSCs. Furthermore, OIP5-AS1 directly targeted and reduced miR-92a-3p expression. The overexpression of miR-92a-3p partly abolished the effects of OIP5-AS1 on LPS-induced cell proliferation and osteogenic differentiation as well as inflammation in hPDLSCs. Collectively, the results indicated that OIP5-AS1 overexpression inhibited the LPS-induced inflammatory response and promoted the osteogenic differentiation of hPDLSCs by sponging miR-92a-3p. Thus, OIP5-AS1 is probably an essential objective for research during periodontitis treatment. Yes OIP5-AS1 overexpression promoted proliferation and osteogenic differentiation ability and reduced LPS-induced inflammation in hPDLSCs. 35546327 MEG8 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissues and cells regulation[miR-107/CDK6 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay MEG8 was strongly expressed while miR-107 was lowly expressed in tumor tissues and cells.Evidence in this work indicated that MEG8 regulates miR-107/CDK6 axis to promote NSCLC progression by activating the Rb/E2F3 pathway. Yes Overexpression of MEG8 potentiated cell proliferation, migration and invasion in BEAS-2B cells. Silencing MEG8 or overexpression of miR-107 clearly hindered cell progression in A549 and H1299 cells. 32649368 OIP5-AS1 LncRNA Homo sapiens Ischemic Stroke HMC3 and SH-SY5Y cells Interaction(miR-155-5p/IRF2BP2 Axis) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//ELISA In OGD/R-induced HMC3 and SH-SY5Y cells, the expression of OIP5-AS1 and IRF2BP2 was reduced while miR-155-5p was elevated. OGD/R induction promoted oxidative stress and inflammatory response in HMC3 and SH-SY5Y cells, while OIP5-AS1 or IRF2BP2 sufficiency as well as miR-155-5p inhibitor attenuated OGD/R-induced these influences. Mechanistically, OIP5-AS1 enhanced IRF2BP2 expression via sponging miR-155-5p. Yes In addition, IRF2BP2 knockdown abolished the suppressive impacts of OIP5-AS1 overexpression on oxidative stress and inflammatory response in OGD/R-induced HMC3 and SH-SY5Y cells. 36460840 hsa_circ_0003146 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cells Interaction(miR-1272/SCARB1 ) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining//Transwell Assay Circ_0003146 upregulation was detected in ccRCC tissues and cells.Tumor growth in vivo was inhibited after knockdown of circ_0003146. Circ_0003146 directly interacted with miR-1272, and the miR-1272 sponging effect was responsible for the function of circ_0003146. Scavenger receptor class B type 1 (SCARB1) was a target of miR-1272, and circ_0003146 regulated SCARB1 level by absorbing miR-1272. The regulation of circ_0003146 in ccRCC progression was achieved by upregulating SCARB1 in part. The current findings demonstrated that circ_0003146 contributed to the malignant progression of ccRCC via inducing SCARB1 upregulation by targeting miR-1272. Yes Downregulation of circ_0003146 induced inhibition of proliferation, migration, invasion and EMT but the promotion of apoptosis in ccRCC cells. 35276698 circPLIN2 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC cells and tissues Interaction(miR-199a-3p and IGF2BP on ZEB1) In Vivo Experiment circPLIN2 was significantly upregulated in ccRCC cells and tissues, and its overexpression was correlated with higher clinical stage and worse prognosis for ccRCC patients.Mechanistically, circPLIN2 not only increased the stability of the c-Myc and MARCKSL1 mRNAs by binding to the KH domains of IGF2BP proteins but also competitively sponged miR-199a-3p to abolish the repressive effect of miR-199a-3p on ZEB1 expression, which ultimately resulted in ccRCC tumorigenesis and progression. circPLIN2 was significantly upregulated in ccRCC cells and tissues, and its overexpression was correlated with higher clinical stage and worse prognosis for ccRCC patients. Yes Moreover, gain- and loss-of-function assays indicated that circPLIN2 promoted ccRCC cell proliferation, migration, and invasion in vitro and ccRCC tumor growth and metastasis in vivo. 36494341 circDVL1 CircRNA Homo sapiens Carcinoma, Renal Cell serums and tissues from ccRCC patients Interaction(miR-412-3p/PCDH7 axis) In Vivo Experiment//Western Blot//qRT-PCR//RNA-seq//Microarray//Cell Cycle Assay//Colony Formation Assay//IF Here we report that circDVL1 to be reduced in the serums and tissues from ccRCC patients, and to negatively correlate with ccRCC malignant features. Mechanistically, circDVL1 serves as a sponge for oncogenic miR-412-3p, thereby preventing miR-412-3p-mediated repression of its target protocadherin 7 (PCDH7) in ccRCC cells. Collectively, our results demonstrate that circDVL1 exerts tumor-suppressive function during ccRCC progression through circDVL1/miR-412-3p/PCDH7 axis, and suggest that circDVL1 could be a novel diagnostic and prognositc marker and therapeutic target for ccRCC. Yes Overexpression of circDVL1 inhibits proliferation, induces G1/S arrest, triggers apoptosis, and reduces migration and invasion in different ccRCC cells in vitro. Correspondingly, circDVL1 overexpression suppresses ccRCC tumorigenicity in a mouse xenograft model. 35280687 OIP5-AS1 LncRNA Homo sapiens Hepatoblastoma hepatoblastoma cells Interaction(PTBP1/ β-catenin ) In Vivo Experiment//IHC//Western Blot//Transfection//Wound Healing Assay//RIP//qRT-PCR//IF//Colony Formation Assay//Transwell Assay OIP5-AS1 was significantly up-regulated in hepatoblastoma cells. OIP5-AS1 bound with PTBP1, and silencing of OIP5-AS1 inhibited β-catenin. Meanwhile, overexpression of PTBP1 or β-catenin activation significantly reversed OIP5-AS1 silencing-inhibited hepatoblastoma cell proliferation and stemness. Moreover, β-catenin was found to be the downstream target of PTBP1, and OIP5-AS1 activated β-catenin signaling via promoting the binding between PTBP1 and β-catenin to increase the mRNA stability of β-catenin. Yes OIP5-AS1 silencing notably attenuated the stemness and invasion of hepatoblastoma cells. Finally, OIP5-AS1 knockdown significantly alleviated the tumor growth of hepatoblastoma by repressing β-catenin. 35255389 OIP5-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissue andcell line Interaction(miR-200c-3p/PTEN) In Vivo Experiment//Wound Healing Assay//qRT-PCR//Cell Apoptosis Assay//Cell Cycle Assay//Colony Formation Assay In the present study, we demonstrated that long noncoding RNA OIP5-AS1 was significantly reduced in EC tissue compared with normal tissue. The lower expression level of OIP5-AS1 was also confirmed in four kinds of EC cell lines compared with the normal endometrial cell line. Moreover, further study revealed that miR-200c-3p could bind to OIP5-AS1, and the loss function of miR-200c-3p could reverse the elevated OIP5-AS1's inhibitory effect on the progression of EC. Furthermore, we found that downregulation of miR-200c-3p was inversely correlated with PTEN expression in EC cells. Reduced OIP5-AS1 could lead to the accumulation of miR-200c-3p, which could induce the upregulation of PTEN indirectly. Yes Gain- and loss-of-function of experiments indicated that upregulation of OIP5-AS1 could inhibit the proliferation, migration, and invasion of EC cells in vitro. Meanwhile, overexpression of OIP5-AS1 could also suppress the growth of tumor in the xenograft model. 34368370 OIP5-AS1 LncRNA Homo sapiens ovarian carcinoma OC tissues interaction[sponging miR-34a ] qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay We observed that the expression of OIP5-AS1 and snail was upregulated and positively correlated with each other in OC. Therefore, OIP5-AS1 may upregulate snail expression in OC by sponging miR-34a to promote OC cell invasion and migration. Yes In cell invasion and migration assay, overexpression of OIP5-AS1 and snail resulted in increased OC cell invasion and migration, while overexpression of miR-34a decreased OC cell invasion and migration. 33092644 circCD44 CircRNA Homo sapiens Glioblastoma glioblastoma multiforme (GBM) tissues and GBM primary cells Interaction(miR-326 and miR-330-5p) In Vivo Experiment//RNA Pull-Down//Immunoblotting//RIP//qRT-PCR//IP//IHC//Invasion Assay Moreover, downregulated expression of circCD44 was found in glioblastoma multiforme (GBM) tissues and GBM primary cells. Mechanistically, circCD44 could regulate the expression of SMAD6 via sponging miR-326 and miR-330-5p involved in the progression of GBM. Yes Re-expression of circCD44 significantly suppressed the proliferation, colony formation, and invasion of GBM cells and inhibited tumor growth in vivo. 34631278 OIP5-AS1 LncRNA Homo sapiens Prostatic Neoplasms PC3 and DU145 cells Interaction(miR-128-3p/SLC7A11 signaling) In Vivo Experiment//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//RNA-seq//H&E Staining//IHC Furthermore, we found that lncRNA OIP5-AS1 expression was greatly elevated in PC3 and DU145 cells upon chronic Cd exposure. Mechanistically, we demonstrated that OIP5-AS1 served as an endogenous sponge of miR-128-3p to regulate the expression of SLC7A11, a surrogate marker of ferroptosis. Yes Dysregulation of OIP5-AS1 expression mediated cell growth and Cd-induced ferroptosis. 34051661 OIP5-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cell lines regulation[miR-204-5p/ZEB1 axis] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The results demonstrated that the expression levels of OIP5-AS1 were significantly increased in LSCC tissues and cell lines. Furthermore, OIP5-AS1 was confirmed to serve as a competing endogenous RNA of miR-204-5p in LSCC cells, and restoration of miR-204-5p counteracted the OIP5-AS1-mediated oncogenic effects. High expression of OIP5-AS1 was closely correlated with lymph node metastasis and advanced clinical stage of LSCC patients. Yes Moreover, in vitro assays showed that OIP5-AS1 overexpression promoted the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of LSCC cells, whereas OIP5-AS1 knockdown exerted suppressive effects on LSCC cells. 32009213 hsa_circ_0006427 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines Regulation[regulating miR-6783-3p/DKK1 axis and inactivating Wnt/β-catenin signaling pathway] qRT-PCR//Microarray Firstly, the downregulation of circ_0006427 in LUAD tissues and cell lines was revealed by microarray analysis and qRT-PCR analysis. Mechanistically, circ_0006427 was found to be predominantly located in the cytoplasm of LUCA cell, and was further revealed to positively regulate DKK1 in LUAD by sponging miR-6783-3p. KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis and western blot analysis revealed that circ_0006427 inactivated Wnt/β-catenin signaling pathway by upregulating DKK1. At last, rescue assays proved the function of circ_0006427/miR-6783-3p/DKK1 axis in LUAD progression. In conclusion, our study revealed that circ_0006427 suppressed lung adenocarcinoma progression through regulating miR-6783-3p/DKK1 axis. Yes Functionally, overexpression of circ_0006427 effectively suppressed cell proliferation, migration and invasion. 30470570 NAP1L6P LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines interaction[ Inhibin-β A] CCK8//qRT-PCR//Colony Formation Assay We identified that lncRNA NAP1L6 was over-expressed both in PCa tissues and cell lines by gene expression array profiling.lncRNA NR6A1 might play an oncogenic role in PCa initiation and progression by regulating the expression of INHBA, and might act as a novel prognostic biomarker for PCa treatment. Besides, high expression level of NAP1L6 promotes PCa cell proliferation, migration, and invasion (all P<0.05), and is significantly associated with larger tumor diameter, distant metastasis, and shorter survival time (all P<0.05). Yes Besides, high expression level of NAP1L6 promotes PCa cell proliferation, migration, and invasion (all P<0.05), and is significantly associated with larger tumor diameter, distant metastasis, and shorter survival time (all P<0.05). We found that NAP1L6 promoted the expression of INHBA (P<0.05), and knockdown of NAP1L6 led to the reduction of PCa cell migration, invasion, and proliferation by regulating the expression of INHBA (all P<0.05). 30154665 OIN1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Regulation(RASSF5/ADORA1 ) CCK8//qRT-PCR//In Vivo Experiment//Western Blot We here show that an unannotated lincRNA originated from chromosome 10q21 and designated as ovarian cancer long intergenic noncoding RNA 1 (OIN1), is often overexpressed in ovarian cancer tissues compared with normal ovaries as analyzed by RNA sequencing. Notably, RNA sequencing showed that OIN1 expression was negatively correlated with the expression of apoptosis-related genes ras association domain family member 5 (RASSF5) and adenosine A1 receptor (ADORA1), which were upregulated by OIN1 knockdown in ovarian cancer cells. Yes OIN1 silencing by specific siRNAs significantly exerted proliferation inhibition and enhanced apoptosis in ovarian cancer cells. 34681900 OIP5-AS1 LncRNA Homo sapiens Gallbladder Neoplasms cell lines regulation[suppressing miR-143-3p] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay OIP5-AS1 was highly expressed and miR-143-3p was downregulated in GBC cell lines, when compared with HGBE cells.LncRNA OIP5-AS1 accelerates the progression of GBC by suppressing miR-143-3p. Yes Overexpression of OIP5-AS1 or downregulation of miR-143-3p facilitated GBC-SD cell invasion, proliferation and migration, while different expression patterns were found in GBC-SD cells in response to OIP5-AS1 suppression or miR-143-3p overexpression. 33364844 OGFRP1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-149-5p/MAP3K3 axis) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//EdU Staining First, high expression of OGFRP1 in GC tissues and cells was determined through RT-qPCR. Subsequently, with the help of the starBase tool, we found that miR-149-5p might bind to OGFRP1, which was confirmed through a luciferase reporter assay. Furthermore, we identified that MAP3K3 was targeted by miR-149-5p in GC cells. Overall, OGFRP1 was determined to promote GC cell proliferation while suppressing cell apoptosis and radiosensitivity by regulating the miR-149-5p/MAP3K3 axis. Yes Finally, the results from rescue experiments validated that enhanced MAP3K3 expression counteracted the effect of OGFRP1 silencing on GC cell proliferation, apoptosis and radiosensitivity. 35050465 circAFAP1 CircRNA Homo sapiens Carcinoma, Renal Cell several renal cancer cell lines Interaction( Circ-AFAP1/miR-374b-3p/VEGFA signaling axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//IHC In this study, we obtained circAFAP1 upregulated in ccRCC by high-sequencing and verified by qRT-PCR in several renal cancer cell lines. We predicted the downstream miR-374b-3p and VEGFA by bioinformatic analysis and validated further by qRT-PCR, RNA pull-down, RIP, and dual-luciferase. Downregulation miR-374b-3p or overexpression VEGFA could restore proliferation, vascular formation after circAFAP1 silencing. Consistently with the results in vitro, silencing circAFAP1 suppressed ccRCC growth in vivo. In conclusion, the circAFAP1/miR-374b-3p/VEGFA axis played a critical role in the progression and development of ccRCC which might be novel biological marks and therapeutical targets. In situ hybridization (ISH) assays and Kaplan-Meier plot showed a higher level of circAFAP1 was linked to shorter overall survival. Yes Moreover, CCK8, colony formation, and EdU experiments showed circAFAP1 promoted ccRCC growth while tube formation displayed circAFAP1 contributed to ccRCC angiogenesis. 35173146 hsa-circ-0000211 CircRNA Homo sapiens Adenocarcinoma of Lung LAC tissues and LAC cell lines Interaction[miR-622/HIF1-α] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay Results revealed the expression of hsa-circ-0000211 in the human LAC tissues and LAC cell lines was higher than that in normal tissue and human lung normal epithelial cells, respectively.Furthermore, hsa-circ-0000211 promoted the migration and invasion of LAC by sponging miR-622. Moreover, hsa-circ-0000211 upregulated the HIF1-α expression by targeting miR-622. hsa-circ-0000211 promoted LAC cell migration and invasion by modulating the miR-622/HIF1-α network. Our study demonstrated that hsa-circ-0000211 can be a potential novel therapeutic target for LAC. Yes The knockdown of hsa-circ-0000211 could inhibit the migration and invasion properties of LAC. 31668923 circPOLR2A CircRNA Homo sapiens Carcinoma, Renal Cell cRCC tissues Interaction(UBE3C/circPOLR2A/PEBP1) RNA Pull-Down//Western Blot//MeRIP//RIP//qRT-PCR//FISH//RNA-seq//IP//Bioinformatics Analysis//IF Bioinformatics analysis revealed that circPOLR2A was highly expressed in cRCC tissues and metastatic cRCC tissues. Further mechanistic research suggested that circPOLR2A could interact with UBE3C and PEBP1 proteins, and that UBE3C could act as a specific ubiquitin E3 ligase for the PEBP1 protein. The UBE3C/circPOLR2A/PEBP1 protein-RNA ternary complex enhanced the UBE3C-mediated ubiquitination and degradation of the PEBP1 protein which could inactivate the ERK signaling pathway. CircPOLR2A expression was associated with tumor size and TNM stage in cRCC patients. Yes In vitro and in vivo functional assays revealed that circPOLR2A accelerated cRCC cell proliferation, migration, invasion and angiogenesis, while inhibiting apoptosis. 35840930 OCC-1D LncRNA Homo sapiens Colorectal Neoplasms colon cancer cells Regulation(Wnt signaling) qRT-PCR//MTT Collectively, we suggested the putative regulatory effects of OCC-1D lncRNA on cell cycle progression and Wnt signaling activation through enhancing the APPL2 gene transcription. Yes Flow cytometry, wound healing and MTT assay confirmed the cell cycle stimulatory effects of OCC-1D in CRC-originated cell lines (SW480 and HCT116). 35397713 MEG8 LncRNA Homo sapiens Hemangioma human hemangioma endothelial cell Interaction(miR‑203) qRT-PCR The knockdown of lncRNA MEG8 significantly inhibited proliferation (P<0.05) and invasion (P<0.05), but promoted apoptosis (P<0.01) in HemECs. Furthermore, lncRNA MEG8 knockdown upregulated miR‑203 (P<0.01) expression, but did not alter miR‑34a or miR‑200b expression (both P>0.05). Yes The knockdown of lncRNA MEG8 significantly inhibited proliferation (P<0.05) and invasion (P<0.05), but promoted apoptosis (P<0.01) in HemECs. 34713294 hsa_circ_0001946 CircRNA Homo sapiens Adenocarcinoma of Lung LAC tissues and cell lines Regulation[regulating miR-135a-5p/SIRT1 axis and activating Wnt/β-catenin signaling pathway] qRT-PCR Among them, circ_0001946 was significantly overexpressed in both LAC tissues and cell lines. Mechanism investigation revealed that circ_0001946 was located in the cytoplasm of LAC cells and acted as a molecular sponge of miR-135a-5p to upregulate Sirtuin 1 (SIRT1) expression. Rescue assays further validated the role of circ_0001946-miR-135a-5p-SIRT1 axis in LAC progression. Additionally, SIRT1 has been demonstrated to be a positive regulator of Wnt/β-catenin signaling pathway. Western blot analysis revealed that circ_0001946 regulated SIRT1/Wnt/β-catenin signaling pathway. In conclusion, our findings suggested that circ_0001946 might be a potential biomarker for the diagnosis or treatment of LAC. In addition, the expression level of circ_0001946 was positively correlated with TNM stage and tumor size. Using Kaplan-Meier analysis, we found that circ_0001946 expression was negatively related with the overall survival of LAC patients. Yes Next, we treated LAC cells with circ_0001946-specific shRNAs and found that knockdown of circ_0001946 inhibited LAC cell growth in vitro and in vivo. 30841451 OECC LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation[NF-κB and p38 MAPK pathway] qRT-PCR//Luciferase Report Assay We identified a novel lncRNA OECC, originating from chromosome 8q24 that is highly expressed in CRC tissues and cell lines and has a positive correlation with liver metastasis. Taken together, our results suggest that lncRNA OECC is overexpressed in CRC and may play an oncogenic role through NF-κB and p38 MAPK pathway activation via miR-143-3p. Yes Attenuation of lncRNA OECC expression prohibited CRC cell proliferation, induced apoptosis, and inhibited migration. 30126634 NAV2-AS5 LncRNA Homo sapiens Osteoarthritis patients with OA Interaction(miR-8082/ TNIP2) Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//ELISA//EdU Staining In our study, patients with OA showed downregulation of NAV2-AS5, upregulation of miR-8082, and downregulation of TNFAIP3 interacting protein 2 (TNIP2). MiR-8082 was predicted to be a target of both NAV2-AS5 and TNIP2. In addition, rescue experiments showed that silencing of TNIP2 reversed the effects of the miR-8082 inhibitor on proliferation, cell cycle, apoptosis, and inflammatory factors in sh-NAV2-AS5-treated chondrocytes. Yes Moreover, we found that both overexpression of NAV2-AS5 and miR-8082 inhibitor promoted cell proliferation, inhibited apoptosis, and released inflammatory cytokines in LPS-treated chondrocytes. 36503346 hsa_circ_0014130 CircRNA Homo sapiens Adenocarcinoma of Lung cell lines Interaction[hsa-miR-566] qPCR//Western Blot The expression level of hsa_circ_0014130 was up-regulated in the three cell lines, and both the overexpression plasmid and the subtractive siRNA were effectively transfected into the cells.hsa_circ_0014130 was capable to target hsa-miR-566 to reduce its expression level and to inhibit epithelial-to-mesenchymal transition. The use of the small molecule inhibitor SB-431542 and simultaneous reduction of hsa_circ_0014130 significantly inhibited the proliferation and invasion of tumor cells. Yes Overexpression of hsa_circ_0014130 was able to promote the proliferation and invasion of tumor cells, and knockdown of hsa_circ_0014130 inhibited the proliferation and invasion of tumor cells. 31818066 MEG8 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(miR-367-3p/14-3-3ζ/TGFβR1 axis) Western Blot//Co-IP//qRT-PCR//RIP//Luciferase Report Assay Results revealed that MEG8 was increased in HCC tissues and cells, and was correlated with the poor prognosis of HCC patients. Moreover, MEG8 sponged miR-367-3p to upregulate 14-3-3ζ, the binding of which suppressed TGFβR1 degradation, thereby enhancing TGFβ signaling. Results revealed that MEG8 was increased in HCC tissues and cells, and was correlated with the poor prognosis of HCC patients. Yes Inhibiting MEG8 significantly repressed the HCC cells' ability to proliferate, migrate, and invade. 33147050 OECC LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Regulation[PI3K/Akt/mTOR signaling pathway] qRT-PCR//RNA-seq//Transwell Assay It was initially revealed that the relative transcript level of OECC was highly upregulated in clinical human lung cancer tissues as well as in cultured lung cancer cells. Furthermore, depletion of OECC in A549 and 95D cells suppressed migration and invasion, which was verified using Transwell assays. RNA-sequence analysis suggested that the phosphoinositide 3-kinase/protein kinase B (Akt)/mammalian target of rapamycin signaling pathway was positively regulated by OECC in lung cancer cells A549. In addition, overexpression of Akt in OECC-depleted A549 and 95D cells reversed the suppression of proliferation and migration caused by OECC depletion. The results of the present study identified lncRNA OECC as a novel regulator of lung cancer progression and provided new clues for the clinical treatment of lung cancer. Yes Knockdown of OECC with specific short hairpin RNAs in lung cancer cell lines A549 and 95D inhibited colony formation and cell viability, as evidenced using colony formation assays and cell proliferation assays. 31452780 hsa_circ_0007766 CircRNA Homo sapiens Adenocarcinoma of Lung cell lines Interaction[Cyclin D1/CyclinE1/CDK4] CCK8//Wound Healing Assay//qPCR//Western Blot The expression of circ_0007766 in lung adenocarcinoma cell lines was detected by qPCR. In this study, the biological function of circ_0007766, a highly expressed circRNA found in a screen of lung adenocarcinoma tissue.Further molecular mechanism studies have found that circ_0007766 can up-regulate the expression of Cyclin D1/Cyclin E1/CDK4, which are the key proteins of cell cycle, and thus promote the malignant proliferation of lung adenocarcinoma. From the perspective of circRNA, this study will provide new clues for the pathogenesis, development and prognosis of lung adenocarcinoma, and provide new target for clinical treatment. Yes In vitro functional studies have shown that circ_0007766 may promote the proliferation and migration of lung adenocarcinoma cells. 31109436 circPSD3 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cell line Interaction(miR-25-3p/FBXW7-EMT axis) In Vivo Experiment//RNA Pull-Down//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay A qRT-PCR analysis performed on our ccRCC cohorts confirmed the downregulation of circPSD3 in ccRCC tissues and further suggested that a low level of circPSD3 expression was associated with tumor metastasis in patients with ccRCC. In summary, circPSD3 inhibits tumor metastasis by repressing the miR-25-3p/FBXW7-EMT axis and might be developed as a potential diagnostic and therapeutic target for ccRCC. A qRT-PCR analysis performed on our ccRCC cohorts confirmed the downregulation of circPSD3 in ccRCC tissues and further suggested that a low level of circPSD3 expression was associated with tumor metastasis in patients with ccRCC. Yes Based on the results of functional studies, circPSD3 significantly inhibited cell migration, invasion, and the epithelial-mesenchymal transition (EMT) in vitro and blocked pulmonary metastasis in vivo. 35295711 OGFRP1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer samples Regulation( AKT/mTOR pathway) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay OGFRP1 was expressed at abnormally high levels in gastric cancer samples (n = 408) compared to normal samples (n = 211). Similar results were obtained in 30 clinical case samples. OGFRP1 promotes tumor progression through activating the AKT/mTOR pathway. Yes Interference of OGFRP1 markedly blocked cell proliferation and migration, and it induced cell cycle arrest and the apoptosis of gastric cancer cells in vitro. The in vivo results further confirmed the antitumor effects of OGFRP1 knockdown on gastric cancer. 33744848 OGFRP1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer (PCa) clinical samples and cell lines interaction[SARM1,miR-124-3p] Wound Healing Assay//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Colony Formation Assay In this research, we found that OGFRP1 was up-regulated in prostate cancer (PCa) clinical samples and cell lines. In conclusion, lncRNA OGFRP1 completely bound to miR-124-3p and relieved their inhibition on SARM1, thus promoting the growth of PCa cells. Additionally, OGFRP1 is significantly associated with TNM stages III and IV and perineural invasion. Yes Knockdown of OGFRP1 inhibited the growth of PCa cells, suggesting a promotional effect of OGFRP1 in tumor progression. 32428870 OGFRP1 LncRNA Homo sapiens Lung Neoplasms lung cancer tumors and cells Interaction(miR-299-3p/SLC38A1 axis) In Vivo Experiment//qRT-PCR//Luciferase Report Assay//Western Blot OGFRP1 and SLC38A1 were overexpressed, whereas miR-299-3p was lowly expressed in lung cancer tumors and cells. Besides, Furthermore, miR-299-3p inhibitor or SLC38A1 overexpression attenuated OGFRP1 depletion-induced suppression on cell proliferation and ferroptosis in lung cancer. Animal experiments indicated that OGFRP1 deficiency restrained tumor growth in vivo by regulating the miR-299-3p/SLC38A1 axis. Yes OGFRP1 knockdown suppressed cell proliferation and facilitated ferroptosis by promoting lipid peroxidation and iron accumulation in lung cancer.Animal experiments indicated that OGFRP1 deficiency restrained tumor growth in vivo by regulating the miR-299-3p/SLC38A1 axis. 36066402 OGFRP1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-4640-5p/eIF5A axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The expression of OGFRP1 in NSCLC tissues were higher than that in normal lung tissue.OGFRP1 can directly interact with miR-4640-5p, and siOGFRP1 increased the level of miR-4640-5p. Moreover, miR-4640-5p could directly bind to the 3' UTR region of eIF5A mRNA. eIF5A was highly expressed in NSCLC tissues, and predicted a poor prognosis. Yes siOGFRP1 inhibited the proliferation, migration and invasion of A549 and H1299 cells. In addition, the expression of EMT-related and apoptosis-related proteins was changed by siOGFRP1 transfection. 34389018 OGFRP1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines interaction[miR-124-3p ] qRT-PCR In the present study, we found that OGFRP1 expression was significantly up-regulated in both NSCLC tissues and cell lines, and the upregulation of OGFRP1 expression is a powerful predictor of advanced clinical stage, lymph nodes metastasis and poor prognosis for NSCLC patients.Mechanistically, OGFRP1 could directly bind to miR-124-3p and effectively act as a competing endogenous RNA (ceRNA) for miR-124-3p to promote the expression of the target gene LYPD3. In the present study, we found that OGFRP1 expression was significantly up-regulated in both NSCLC tissues and cell lines, and the upregulation of OGFRP1 expression is a powerful predictor of advanced clinical stage, lymph nodes metastasis and poor prognosis for NSCLC patients. Yes Loss-of-function assay indicated that knockdown of OGFRP1 inhibited proliferation, migration and invasion, and induced apoptosis in vitro. 30274775 circNF1 CircRNA Homo sapiens Glioblastoma  Tumor tissues and adjacent non-cancerous tissues  Interaction(mature miR-340) Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay circNF1 expression was found to be upregulated in GBM and was correlated with patient survival. In glioma tissue, circNF1 was inversely correlated with mature miR-340, but not with the miR-340 precursor. circNF1 expression was found to be upregulated in GBM and was correlated with patient survival. Yes In GBM cells, circNF1 siRNA silencing resulted in the upregulation of mature miR-340, but not the miR-340 precursor. The cell proliferation assay showed that circNF1 siRNA silencing and miR-340 overexpression decreased the proliferation of GBM cells. 34589042 OIP5-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC cells Interaction(miRNA-320b/FOXM1/ Wnt/β-Catenin Pathway ) RNA Pull-Down//Northern Blot//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//FISH//Luciferase Report Assay//EdU Staining//Transwell Assay OIP5-AS1 downregulating inhibited cell proliferation, migration, and invasion capacities, while promoting cell apoptosis rates.As a competing endogenous RNA (ceRNA), OIP5-AS1 competed with Forkhead Box M1 (FOXM1) for the binding sites on microRNA-320b (miR-320b). OIP5-AS1 was able to upregulate FOXM1 expression via silencing miR-320b Yes OIP5-AS1 downregulating inhibited cell proliferation, migration, and invasion capacities, while promoting cell apoptosis rates. 33782807 MEG8 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patient tissues Interaction(miR-15a-5p-miR-15b-5p/PSAT1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay We revealed that the expression levels of MEG8 were elevated in the NSCLC patient tissues compared to that in adjacent normal tissues. The expression of MEG8 was negatively relative to that of miR-15a-5p and miR-15b-5p in the NSCLC patient tissues. The expression of MEG8 was upregulated, while miR-15a-5p and miR-15b-5p were downregulated in NSCLC cell lines. Thus, we concluded that lncRNA MEG8 promotes NSCLC progression by modulating the miR-15a/b-5p/PSAT1 axis. Yes The depletion of MEG8 inhibited NSCLC cell proliferation, migration, and invasion in vitro. MEG8 contributed to NSCLC progression by targeting miR-15a-5p/miR-15b-5p in vitro. LncRNA MEG8 contributes to tumor growth of NSCLC via the miR-15a/b-5p/PSAT1 axis in vivo. 33526036 NALCN CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-493-3p/PTEN) Western Blot//ISH//Wound Healing Assay//Transfection//Migration Assay//Proliferation Assay//qRT-PCR//FISH//migration assay//PCR//IF The downregulated expression of circNALCN was observed in both glioma tissues and cell lines. The mechanistic analysis demonstrated that circNALCN acted as a competing endogenous RNA for miR-493-3p to relieve the repressive effects of miR-493-3p on its target, PTEN, suppressing glioma tumorigenesis. CircNALCN expression was negatively correlated with World Health Organization grade and overall survival in patients with glioma. Yes Functionally, the overexpression of circNALCN significantly inhibited the proliferation and migration of glioma cells, whereas miR-493-3p mimics counteracted these effects. 34112159 OIP5-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction(miR-124-5p/IDH2/HIF-1α Pathway ) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//FISH//Cell Proliferation Assay//Colony Formation Assay//IF Herein, we find that lncRNA OIP5-AS1 is up-regulated in cervical cancer tissues and predicts poor 5-years overall survival in cervical cancer patients, and it promotes cell proliferation of cervical cancer cells in vitro and in vivo.In conclusion, hypoxia induced OIP5-AS1 promotes the Warburg effect through miR-124-5p/IDH2/HIF-1α pathway in cervical cancer. Herein, we find that lncRNA OIP5-AS1 is up-regulated in cervical cancer tissues and predicts poor 5-years overall survival in cervical cancer patients, and it promotes cell proliferation of cervical cancer cells in vitro and in vivo. Yes Herein, we find that lncRNA OIP5-AS1 is up-regulated in cervical cancer tissues and predicts poor 5-years overall survival in cervical cancer patients, and it promotes cell proliferation of cervical cancer cells in vitro and in vivo. 34513821 OIP5-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms interaction[miR-143-3p,ROCK1 ] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay Here, we demonstrated that lncRNA OIP5-AS1 was upregulated in cervical cancer and was correlated with poor prognosis by bioinformatics studies.Finally, we verified that OIP5-AS1 exerted its function in the regulation of cervical cancer progression via interacting with miR-143-3p to regulate ROCK1 expression. Here, we demonstrated that lncRNA OIP5-AS1 was upregulated in cervical cancer and was correlated with poor prognosis by bioinformatics studies. Yes OIP5-AS1 depletion inhibited cell proliferation and promoted cell apoptosis in cervical cancer cells. 31939597 circMTO1 CircRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues and adjacent tissues Interaction[circ-MTO1/miR-17/QKI-5] qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay Here, we found that circ-MTO1 was significantly Expression[down-expression]-regulated in LUAD, which was closely associated with malignant features and dismal prognosis.Subsequent mechanism experiments showed that circ-MTO1 served as a sponge of oncogenic miR-17 to increase the expression of RNA-binding protein QKI-5, leading to the inactivation of Notch signaling pathway, thereby restraining the growth of LUAD. Yes Enforced expression of circ-MTO1 sExpression[Expression[up-expression]-expression]pressed the growth of LUAD cells both in vitro and in vivo. 30975029 OIP5-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Interaction[sponging miR-143-3p ] qRT-PCR In the current study, we found that lncRNA OIP5-AS1 was upregulated in CC tissues and cell lines. In conclusion, we demonstrated that OIP5-AS1 promoted proliferation and invasion of CC cells via increasing the ITGA6 expression by sponging miR-143-3p, which might be an effective therapeutic target for the treatment of patients with CC. High OIP5-AS1 expression was significantly correlated with advanced International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis, and poor overall survival of patients with CC. Yes Using in vitro function assays, we showed that OIP5-AS1 suppression significantly decreased the proliferation, colony formation, and invasion ability of CC cells. 30188591 NAA25 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Expression(highly expressed) Western Blot//qRT-PCR//RNA-seq//Cell Cycle Assay//Colony Formation Assay Based on the public database, such as TCGA and Curtis dataset, NAA25 gene is highly expressed in breast cancer tissues and this result has also been proved in our samples and cell lines through RT-qPCR and western blot analysis. Based on the public database, such as TCGA and Curtis dataset, NAA25 gene is highly expressed in breast cancer tissues and this result has also been proved in our samples and cell lines through RT-qPCR and western blot analysis. Yes We found that NAA25-deficient cells could increase cell apoptosis, delay G2/M phase cell and decrease cell clone formation. RNA sequencing was then applied to analyze the molecular profiles of NAA25-deficient cells, and compared to the control group, NAA25 knockdown could activate apoptosis-related pathways, reduce the activation of tumor-associated signaling pathways and decrease immune response-associated pathways. 35096568 OIP5-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines Interaction[sponging miR-143-3p] qRT-PCR//Luciferase Report Assay//Transwell Assay//Western Blot SMAD3, lncRNA OIP5-AS1 expression is significantly enhanced in cervical cancer tissues and cell lines, but miR-143-3p was inhibited. Furthermore, lncRNA OIP5-AS1 exert its function via sponging miR-143-3p to regulate SMAD3 expression. Yes Moreover, silencing SMAD3 via siRNA suppressed cell number, viability, migration and invasion, whereas overexpression of OIP5-AS1 promoted these abilities. 30341904 OIP5-AS1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues and cell lines regulation[miR-429/FOXD1/ERK pathway] qRT-PCR//RNA Pull-Down//Luciferase Report Assay OIP5-AS1 was up-regulated in PDAC tissues and cell lines, and high level of OIP5-AS1 indicated poor prognosis in PDAC patients.OIP5-AS1 exerted oncogenic function in PDAC cells through targeting miR-429/FOXD1/ERK pathway. OIP5-AS1 was up-regulated in PDAC tissues and cell lines, and high level of OIP5-AS1 indicated poor prognosis in PDAC patients. Yes OIP5-AS1 knockdown hindered cell proliferation, migration and epithelial-mesenchymal transition (EMT) process, while overexpression of OIP5-AS1 caused the opposite results. 32669972 OIP5-AS1 LncRNA Homo sapiens Esophageal Neoplasms EC tissues and cultured EC cells Interaction( miR-30a/VOPP1 expression) qRT-PCR//MTT//RIP The results revealed that OIP5-AS1 expression in EC tissues and cultured EC cells was upregulated, microRNA-30a (miR-30a) expression was downregulated. miR-30a was confirmed to interact with OIP5-AS1, and miR-30a-mimics transfection ameliorated the effects of OIP5-AS1 in EC cells. Vesicular overexpressed in cancer prosurvival protein 1 (VOPP1) was verified as the direct target of miR-30a. VOPP1 expression was positively correlated with OIP5-AS1 expression in EC cells. Overexpression of VOPP1 ameliorated the negative effects of OIP5-AS1-knockdown on EC9706 and EC109 cells. Yes OIP5-AS1-knockdown suppressed the proliferation, migration and invasion of EC9706 and EC109 cells. 34386073 OIP5-AS1 LncRNA Homo sapiens Parkinson Disease SH-SY5Y cells, MPP+ cells Interaction( miR-137) qRT-PCR//Luciferase Report Assay OIP5-AS1 was downregulated in MPP+ cells. Collectively, lncRNA OIP5-AS1 promoted NIX expression through competitively binding to miR-137, and promoted mitochondrial autophagy, thus protecting neurons from degeneration which might be seen in patients with PD. Yes After OIP5-AS1 overexpression, miR-137 was downregulated and NIX was upregulated in MPP+ cells, inflammatory factors and chemokines were downregulated. There were target relationships between OIP5-AS1 and miR-137, and miR-137 and NIX. After OIP5-AS1 overexpression, miR-137 overexpression or NIX downregulation inhibited mitochondrial autophagy and ROS levels and aggravated mitochondrial vacuolation; and partially reversed the effect of OIP5-AS1 overexpression on promoting mitochondrial autophagy and protection on MPP+ cells. 35049152 OIP5-AS1 LncRNA Homo sapiens Osteosarcoma OS cells and exosomes secreted by cells Interaction(miR-153 and ATG5) qRT-PCR The results of RT-PCR showed that lncRNA OIP5-AS1 levels were elevated in OS cells and exosomes secreted by cells. According to the results of bioinformatics tools and dual-luciferase reporter (DLR) assay or RNA immunoprecipitation (RIP), miR-153 targeted the 3'-UTR of lncRNA OIP5-AS1 and autophagy-related protein 5 (ATG5). The results of western blot (WB) assay showed that exosomal lncRNA OIP5-AS1 and down-regulated miR-153 led to the enhancement of ATG5 protein expression, while up-regulated miR-153 resulted in the decrease of ATG5 protein expression. Yes Cell function experiments revealed that the proliferation, migration, and invasion of OS cells were promoted by exosomal lncRNA OIP5-AS1. In exosomes, lncRNA OIP5-AS1 inhibited the expression of LC3-II and Beclin 1 proteins, indicating that exosomal lncRNA OIP5-AS1 inhibited autophagy. 34150009 OIP5-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissue and cells Regulation[OIP5-AS1/miR-223/CDK14 axis ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay Results revealed that OIP5-AS1 level was elevated in osteosarcoma tissue and cells. In conclusion, our study found the critical regulation of OIP5-AS1/miR-223/CDK14 axis on osteosarcoma tumorigenesis, indicating the tumor promoting role of OIP5-AS1 for osteosarcoma. Clinically, OIP5-AS1 high-expression was closely correlated with osteosarcoma patients' poor prognosis. Yes Mechanistically, silenced OIP5-AS1 expression significantly repressed the proliferative ability and accelerated the apoptosis, meanwhile triggered G0/G1 phase cycle arrest in vitro and mice neoplasm growth in vivo. 30119217 OIP5-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Regulation[miR-338-3p/NRP1 axis] qRT-PCR We found that OIP5-AS1 was up-regulated in OSCC tissues compared with adjacent non-tumor tissues. The current results provide evidences for the role of OIP5-AS1 in promoting OSCC progression by regulating miR-338-3p/NRP1 axis and suggest OIP5-AS1 as a potential therapy target for OSCC. Yes Loss-of-function experiments revealed that OIP5-AS1 knockdown significantly inhibited OSCC cell proliferation, migration and invasion in vitro, and retarded tumor growth in vivo. 31369989 OIP5-AS1 LncRNA Homo sapiens Hemangioma hemangioma tissues,cell lines Regulation[miR-195-5p/NOB1 Axis] Western Blot//Flow Cytometry//qRT-PCR//RIP//FISH//MTT It was found that OIP5-AS1 was overexpressed in both hemangioma tissues and HemECs cells. Taken together, lncRNA OIP5-AS1 acted as a ceRNA to drive proliferation, migration and invasion of HemECs through regulating miR-195-5p/NOB1 axis. Yes OIP5-AS1 knockdown suppressed the proliferation, migration, and invasion of HemECs cell, while overexpression of OIP5-AS1 had opposite effects LncRNA OIP5-AS1 acted as a ceRNA through binding with miR-195-5p to upregulate NOB1 in HemECs. 31068824 OIP5-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms Bladder cancer tissue Expression[highly expressed] CCK8//qRT-PCR//Western Blot In our study, OIP5-AS1 was overexpressed in bladder cancer, and associated with clinical progression and short overall survival. In our study, OIP5-AS1 was overexpressed in bladder cancer, and associated with clinical progression and short overall survival. Yes The loss-of-function studies suggested downregulation of OIP5-AS1 expression decreased cell viability, induced cell-cycle arrest and promoted cell apoptosis in bladder cancer. 30485498 OIP5-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and cells Interaction(miR-92a/ITGA6) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay OIP5-AS1 and ITGA6 were upregulated while miR-92a was downregulated in OC. OIP5-AS1 as a competing endogenous RNA interacted with miR-92a to regulate ITGA6. Yes Inhibited OIP5-AS1 or downregulated ITGA6 or elevated miR-92a repressed EMT, viability, migration and invasion, and promoted apoptosis of OC cells. 35168644 circTSPAN4 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD and paracancerous tissues Interaction[ZEB1,miR-665] qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay Circ-TSPAN4 was significantly Expression[Expression[up-expression]-expression]regulated in LUAD tissues and cell lines.Mechanistically, circ-TSPAN4 directly interacted with miR-665, but not miR-4731-5p, to increase the expression of ZEB1, which is a well-known metastasis trigger. Importantly, the reduced metastatic capacity caused by circ-TSPAN4 depletion was partially rescued by miR-665 silencing or ZEB1 overexpression. The increased circ-TSPAN4 was linked to advanced tumor-node-metastasis stage, lymph node and distant metastasis, and poor outcome. Yes Lentivirus-mediated stably circ-TSPAN4 knockExpression[down-expression] dramatically attenuated the metastatic ability of LUAD cells both in vitro and in vivo. 31573758 OIP5-AS1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues and OC cell lines regulation[miR-324-3p/NFIB axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay OIP5-AS1 and NFIB were validated to be upregulated in both OC tissues and OC cell lines. The present study clarified that OIP5-AS1 accelerated OC progression by sponging miR-324-3p and upregulating NFIB. Yes Functionally, OIP5-AS1 knockdown and miR-324-3p overexpression restrained SKOV3 cell viability, invasion, and migration. 32706064 OIP5-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and tissues regulation[miR-3163/VEGFA] qRT-PCR In the first place, qRT-PCR found that OIP5-AS1 and VEGFA expressions were significantly increased while miR-3163 was obviously reduced in HCC cells and tissues. In summary, OIP5-AS1 affects HCC proliferation, metastasis, and angiogenesis in HCC by regulating VEGFA expression through sponging miR-3163. Yes Next, a series of functional experiments found that knockdown of OIP5-AS1 suppressed HCC cell proliferation, migration and angiogenesis abilities while promoting cell apoptosis simultaneously. 32329664 OIP5-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Interaction[miR-363-3p ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//H&E Staining//Cell Cycle Assay//Colony Formation Assay//EdU Staining//Transwell Assay Currently, we found OIP5-AS1 expression was upregulated in HCC cells compared with normal human liver cells. Collectively, these demonstrated that OIP5-AS1 was involved in HCC progression via targeting miR-363-3p and SOX4. Yes Knockdown of OIP5-AS1 suppressed HCC cell proliferation, induced cells cycle arrest and cells apoptosis. In addition, HCC cell migration and invasion capacity in vitro were also inhibited by OIP5-AS1 inhibition. 32042127 hsa_circ_0025036 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues Regulation[ hsa_circ_0025036/miR-198/SHMT1&TGF-α axis] qRT-PCR The results in this study revealed that hsa_circ_0025036 existed as a circular form and was aberrantly upregulated in lung adenocarcinoma tissues via quantitative reverse transcription-polymerase chain reaction (qRT-PCR). In conclusion, we demonstrate that hsa_circ_0025036 regulates cell proliferation and apoptosis in lung adenocarcinoma cells probably via hsa_circ_0025036/miR-198/SHMT1&TGF-α axis. Its expression level exhibited a close link with aggressive clinicopathological parameters including cancer differentiation, TNM stage and lymph node metastasis. Yes hsa_circ_0025036 knockdown significantly suppressed cell proliferation and promoted cell apoptosis in A549 and Calu-3 cells. 30138108 circCAMK2A CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction[regulating the miR-615-5p/fibronectin 1 pathway] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Mechanistically, miR-615-5p was identified as a direct target of circ-CAMK2A. Circ-CAMK2A Expression[Expression[up-expression]-expression]-regulates the expression level of fibronectin 1 by sponging miR-615-5p, thereby increasing MMP2 and MMP9 expression to promote the metastasis of LUAD. Circ-CAMK2A overexpression was observed in LUAD and was closely associated with lymph node metastasis, distant metastasis, advanced clinical stage, and poor prognosis. Yes Circ-CAMK2A silencing evidently inhibited LUAD cell migration and invasion, whereas circ-CAMK2A overexpression had an opposite effect. Importantly, overexpression of circ-CAMK2A also enhanced LUAD metastasis in vivo. 31889960 OIP5-AS1 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues regulation[AKT/ERK signaling pathway] qRT-PCR//Luciferase Report Assay Quantitative real-time PCR analysis revealed that OIP5-AS1 is highly expressed in pancreatic cancer tissues versus adjacent non-tumor tissues.Therefore, we demonstrate that OIP5-AS1 functions as oncogene in pancreatic cancer and its downregulation inhibits pancreatic cancer growth by sponging miR-342-3p via targeting AGR2 through inhibiting AKT/ERK signaling pathway. Yes Further, knockdown of OIP5-AS1 suppressed tumor growth in a xenograft mouse model of pancreatic cancer. 32157498 NALT1 LncRNA Homo sapiens Colorectal Neoplasms 76 CRC patients and CRC cell line Interaction(miRNA-574-5p/PEG10 ) qRT-PCR//RNA Pull-Down It was observed that high expression of NALT1 was markedly correlated with advanced cancer stage in the clinic. Bioinformatics analysis, RNA pulldown, Ago2-RIP, and luciferase reporter assays showed that miRNA-574-5p was a target of NALT1. Additionally, dual-luciferase reporter assays, Ago2-RIP, and rescue experiments indicated that miRNA-574-5p could target the PEG10 gene directly. It was observed that high expression of NALT1 was markedly correlated with advanced cancer stage in the clinic. Yes Functionally, NALT1 downregulation inhibited cell proliferation, migration and invasion, whereas NALT1 overexpression exhibited an opposite trend both in vivo and in vitro. 36385135 OIP5-AS1 LncRNA Homo sapiens Multiple Myeloma bone marrows regulation[miR-27a-3p/TSC1 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU The expression levels of OIP5-AS1 and TSC1 were decreased in MM, whereas miR-27a-3p was upregulated.OIP5-AS1 repressed multiple myeloma progression by regulating miR-27a-3p/TSC1 axis. High level of OIP5-AS1 could predict favourable prognosis of MM patients. Yes Overexpression of OIP5-AS1 inhibited cell viability, colony formation ability, migration and invasion, induced cell cycle arrest in G1 phase and apoptosis of MM cells in vitro as well as repressed tumorigenesis in vivo. 32410883 MELK LncRNA Homo sapiens Osteoarthritis OA human cartilage tissue, chondrocytes Interaction(miR-497-5p/MYD88/NF-κB signaling axis) RNA Pull-Down//Flow Cytometry//RIP//Luciferase Report Assay//Cell Viability Assay//ELISA The data presented that OA cartilage tissues presented raised circMELK and MYD88 and inhibited miR-497-5p expression. circMELK acted as a sponge of miR-497-5p while miR-497-5p was a regulator of MYD88. MYD88 restricted the effect of overexpressing miR-497-5p on IL-1β-stimulated chondrocytes. MYD88 triggered nuclear factor-kappaB (NF-κB) pathway activation. Yes IL-1β suppressed cell viability, prevented cell cycle, and induced apoptosis, autophagy, and inflammation of chondrocytes. Functionally, IL-1β-induced changes of chondrocytes could be attenuated by suppressing circMELK or overexpressing miR-497-5p. 35992546 OIP5-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC cell Interaction(miR-98/ADAMTS8 signaling) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Microarray//Cell Proliferation Assay//IHC//Transwell Assay Functional validation revealed that OIP5-AS1 overexpression promotes PTC cell proliferation, migration/invasion in vitro and in vivo, while OIP5-AS1 knockdown shows an opposite effect.Mechanistically, OIP5-AS1 acts as a target of miR-98, which activates ADAMTS8. OIP5-AS1 promotes PTC cell progression through miR-98/ADAMTS8 and EGFR, MEK/ERK pathways. Furthermore, RIP and RNA pull down assays identified OIP5-AS1 as the downstream target of METTL14. Yes Functional validation revealed that OIP5-AS1 overexpression promotes PTC cell proliferation, migration/invasion in vitro and in vivo, while OIP5-AS1 knockdown shows an opposite effect. Overexpression of METTL14 suppresses PTC cell proliferation and migration/invasion through inhibiting OIP5-AS1 expression and regulating EGFR, MEK/ERK pathways. 34131102 MELTF LncRNA Homo sapiens Uterine Cervical Neoplasms cervical tissues Regulation[PI3K/AKT signaling pathway] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Our research validated that MFI2 was up-regulated in cervical cancer by qRT-PCR.The results indicated that MFI2 may exert its function by regulating phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. Yes we verified that MFI2 can promote cell proliferation, cell metastasis and inhibit cell apoptosis in cervical cancer. In tumor xenograft formation assay, up-regulated MFI2 accelerated tumor formation. 31210294 MELTF-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-1299) CCK8//qRT-PCR MELTF-AS1 was increased in NSCLC tissues and cells. In addition, through luciferase activity analysis and bioinformatics analysis, MELTF-AS1 has a negative effect on miR-1299, and silencing MELTF-AS1 enhanced miR-1299 expression in NSCLC cells. Yes Silencing MELTF-AS1 suppressed the proliferation ability, migration capability and invasion level of NSCLC cells, which means that low expression of MELTF-AS1 may be more conducive to patient survival. 35441579 OIP5-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines Interaction(miR-429) Western Blot//qRT-PCR//MTT//BrdU//Transwell Assay In this work we reported that OIP5-AS1 expression was up-modulated in PTC tissues and cell lines. OIP5-AS1 overexpression enhanced the proliferation and metastasis of PTC cells, but the transfection of miR-429 mimics reversed the functions of OIP5-AS1 on the proliferation, migration, and invasion of PTC cells. Yes OIP5-AS1 overexpression enhanced the proliferation and metastasis of PTC cells, but the transfection of miR-429 mimics reversed the functions of OIP5-AS1 on the proliferation, migration, and invasion of PTC cells. 34155880 circDUSP22 CircRNA Homo sapiens Pancreatic Neoplasms PaCa samples and cells Interaction( miR-1178-3p/BNIP3) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining The decreased expression of circDUSP22 was observed in PaCa samples and cells. CircDUSP22 targeted miR-1178-3p, whose expression was reinforced in PaCa. The inhibitory cell growth caused by circDUSP22 ectopic expression was reversed by miR-1178-3p enrichment. In addition, miR-1178-3p targeted BNIP3, whose expression was declined in PaCa. The inhibitory cell growth caused by circDUSP22 ectopic expression was reversed by BNIP3 knockdown. Yes CircDUSP22 ectopic expression in vitro blocked PaCa cell proliferation, arrested cell cycle and provoked cell apoptosis. CircDUSP22 overexpression in vivo decelerated tumor growth. 36063260 MELTF-AS1 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer tissues regulation[ MFI2-AS1/miR-125a-5p Axis ] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay MFI2-AS1 was shown to be highly expressed in thyroid cancer tissues and predicted poor prognosis.Our results elucidated a novel mechanism that MFI2-AS1 promotes thyroid cancer progression via the miR-125a-5p/TRIAP1 pathway. MFI2-AS1 was shown to be highly expressed in thyroid cancer tissues and predicted poor prognosis. Yes Knockdown of MFI2-AS1 inhibited proliferation, colony formation, migration and invasion of thyroid cancer cells in vitro. 32764987 OIP5-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC patient specimens and NPC cell lines Interaction(miR-203) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay Here, we find that OIP5-AS1 is overexpressed in NPC patient specimens and NPC cell lines.Interestingly, there is a functional link between OIP5-AS1 and microRNA-203 (miR-203), a tumor suppressor, in NPC cells. Yes Further investigations reveal that knockdown of OIP5-AS1 significantly inhibits the proliferation, migration, and invasion and accelerates the apoptosis of NPC cells in vitro. Consistent with these findings, NPC progression is significantly slowed in mice when OIP5-AS1 is knocked down. 33628831 MELTF-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells Regulation(MMP14 ) qRT-PCR//Luciferase Report Assay The qRT-PCR analysis showed that the expression of MELTF-AS1 was increased in osteosarcoma tissues and cells, and the high expression of MELTF-AS1 indicated a poor prognosis of osteosarcoma patients. The high expression of MELTF-AS1 in osteosarcoma was partly due to the transcriptional activation of RREB1.Furthermore, the results of RNA pull-down assays, luciferase reporter assays, and RNA immunoprecipitation (RIP) assays revealed that MELTF-AS1 could regulate MMP14 expression through interaction with miR-485-5p. The qRT-PCR analysis showed that the expression of MELTF-AS1 was increased in osteosarcoma tissues and cells, and the high expression of MELTF-AS1 indicated a poor prognosis of osteosarcoma patients. Yes The results of transwell assays, scratch wound healing assays, and the tail vein injection lung metastasis model demonstrated that knocking down MELTF-AS1 inhibited metastasis ability of osteosarcoma cells. 34729248 MELTF-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and HCC cell line regulation[miR-134,FOXM1 ] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay In addition, up-regulation of MFI2-AS1 was further comfirmed in HCC tissues and HCC cell line. Collectively, we determined that MFI2-AS1 crucially acted in HCC progression via functioning as miR-134 sponge to upregulating FOXM1 expression, and was conducive to the promotion of better understanding the direct diagnostics and iatreusiology of lncRNA in HCC. Yes Ectopic expression of MFI2-AS1 stimulated the proliferation and metastasis of HCC cells, but knockdown MFI2-AS1 suppressed HCC cell proliferation and metastasis, indicating that MFI2-AS1 exerted oncogenic functions in the tumorigenesis of HCC. 32106369 MELTF-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[miR-574-5p/MYCBP axis] Western Blot//Wound Healing Assay//CCK8//FISH//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay LncRNA MFI2-AS1 and MYCBP were up-regulated in CRC tissues when compared with adjacent non-tumour tissues. These findings suggested that lncRNA MFI2-AS1 and MYCBP have promoting effects in CRC tissues. LncRNA MFI2-AS1 promoted CRC cell proliferation, migration and invasion through activating MYCBP and by sponging miR-574-5p. The expression levels of MFI2-AS1 were significantly associated with tumour histological grade, lymph and distant metastasis, TNM stage and vascular invasion. Yes Both MFI2-AS1 siRNA and miR-574-5p mimics inhibited proliferation, migration and invasion in LoVo and RKO cells. 31094023 hsa_circ_0000994 CircRNA Homo sapiens Pancreatic Neoplasms PC tissues and PC cell lines Interaction(miR-27a and miR-27b) Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay Hsa_circ_0000994 was lowly expressed in PC tissues as well as various PC cell lines, and this low expression was closely related to cancer. Mechanically, Hsa_circ_0000994 inhibited miR-27a and miR-27b. Hsa_circ_0000994 inhibited the cancer cells through the effect on miR-27a and miR-27b. In summary, a circRNA with tumor suppressor effects on PC has been elucidated. Yes In terms of functional testing, Hsa_circ_0000994 suppressed core ability of PC cells, including proliferation, migration, and invasion ability. Xenotransplantation studies further confirmed the effect of Hsa_circ_0000994 in promoting cell growth. 35669238 circFGFR1 CircRNA Homo sapiens Pancreatic Neoplasms PDAC cell Interaction(MicroRNA-532-3p/PIK3CB Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//ISH//Transfection//Wound Healing Assay//Colony Formation Assay//Flow Cytometry//FISH//qRT-PCR//MTT//Luciferase Report Assay//IHC//Invasion Assay In addition, circFGFR1 could sponge miR-532-3p to upregulate PIK3CB level. Rescue experiments revealed that the tumor-suppressive effects caused by miR-532-3p mimics could be reversed by circFGFR1 or PIK3CB overexpression. Yes Functionally, knockdown of circFGFR1 restrained in vitro PDAC cell growth, migration, invasion, and in vivo xenograft tumor growth and lung metastasis. 36607937 hsa_circ_0050102 CircRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells Interaction(miR-218-5p/PPME1 axis) In Vivo Experiment//IHC//Western Blot//Transfection//Tube Formation Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Hsa_circ_0050102 and PPME1 contents were increased, and the miR-218-5p was dwindled in PC. Furthermore, miR-218-5p was established to block the development of PC cells via PPME1. Hsa_circ_0050102 bound to miR-218-5p to adjust the content of PPME1. Yes Hsa_circ_0050102 lack subdued cell vitality, colony formation, cell migration and invasion, and angiogenesis, but endorsed cell apoptosis in PC cells. 35060203 hsa_circ_0008768 CircRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines Interaction(miR-330- 3p/PTEN Axis) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay The expression levels of circ_0008768 and PTEN mRNA were significantly reduced in both PC tissues and cell lines. Circ_0008768 directly targeted and negatively regulated the expression of miR-330- 3p. PTEN was identified as a downstream target gene of miR-330-3p. Circ_0008768 could positively regulate the expression of PTEN. Yes Overexpression of circ_0008768 exerted an inhibitory effect on the proliferation, migration and invasion of PC cells. Knocking down circ_0008768 showed the opposite effect. 35894462 circPARP4 CircRNA Homo sapiens Glioblastoma 36 high-grade gliomas (WHO grade III-IV) and 40 low-grade gliomas (WHO grade I-II) Interaction( miR-125a-5p/FUT4 pathway) In Vivo Experiment//Western Blot//Tunel//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//IHC//Invasion Assay The results confirmed the elevated expression of circPARP4 in glioma and found its association with glioma pathological grade. Mechanistically, in vivo and in vitro studies demonstrated that circPARP4, as a miRNA sponge, directly interacted with miR-125a-5p, which then regulated FUT4 to exert the oncogenic effect on glioma behavior. The results confirmed the elevated expression of circPARP4 in glioma and found its association with glioma pathological grade. Yes Gain- and loss-of-function strategies showed that circPARP4 could obviously promote glioma cell proliferation, migration, invasion, and epithelial-mesenchymal transition. 33520365 OIP5-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms tumor tissues, cell lines Hela, CaSki, Siha, and ME-180 Interaction(miR-147a/IGF1R pathway) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//Transwell Assay OIP5-AS1 showed the high-expression and miR-147a showed the low-expression in tumor tissues collected from patients with cervical cancer and cell lines Hela, CaSki, Siha, and ME-180. There were targeting sites between miR-147a and OIP5-AS1. OIP5-AS1 induced the down-regulation of miR-147a, so miR-147a was inversely correlated with OIP5-AS1. The down-regulation of miR-147a increased IGF1R and E-cadherin, and these increases were alleviated by OIP5-AS1 knockdown. Yes The low-expression of OIP5-AS1 suppressed the motility of Caski cells, as well as up-regulated the level of E-cadherin, which a key protein in EMT. 35233882 n384546 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues,cell lines Interaction[n384546/miR-145-5p/AKT3 pathway ] qRT-PCR//RNA-seq We identified a novel lncRNA, n384546, which is highly expressed in PTC tissues and cell lines. In addition, we identified miR-145-5p as a key miRNA target of n384546 using online bioinformatics tools. Anti-miR-145 could partially reverse the effects of n384546 knockdown. Furthermore, we found that n384546 could regulate the expression of AKT3 by sponging miR-145-5p, which was confirmed using an in vitro luciferase assay. In conclusion, we validated n384546 as a novel oncogenic lncRNA in PTC and determined that the n384546/miR-145-5p/AKT3 pathway contributes to PTC progression, which might be used as potential therapeutic targets for PTC patients. n384546 expression was associated with clinicopathological features of PTC patients, such as tumor size, lymph node metastasis, and TNM stage. Yes Functionally, knockdown of n384546 inhibited PTC cell proliferation, invasion, and migration both in vitro and in vivo. 31160577 circZKSCAN1 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tumor tissues and cells Interaction(miR-1294/PIM1 axis) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay Our results suggested that circZKSCAN1 was abundantly expressed in ccRCC tumor tissues and cells.Furthermore, we identified a novel circZKSCAN1/miR-1294/PIM1 axis was identified in RCC progression, showing that the expression of circZKSCAN1 expression in RCC cells was transcriptionally regulated by Kruppel-like factor 2. Yes CircZKSCAN1 knockdown significantly inhibited cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition of renal cell carcinoma (RCC) cells, whereas potentiated Natural Killer (NK) cell-mediated cytotoxicity against RCC cells in vitro and repressed tumor growth in vivo. 35285410 NBAT1 LncRNA Homo sapiens Endometrial Neoplasms EC cells and tumor tissues Interaction(miR-21-5p/ PTEN) Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay NBAT1 is downregulated, and miR-21-5p is upregulated in EC cells and tumor tissues. Overexpression of NBAT1 inhibits the proliferation, migration, and invasion abilities of EC cells and facilitated apoptosis. NBAT1 directly binds and negatively regulates miR-21-5p in EC. miR-21-5p mimics reverses the effect of lncRNA NBAT1 overexpression on the proliferation and migration of EC cells. PTEN is a downstream gene of miR-21-5p. lncRNA NBTA1 elevates PTEN expression via sponging miR-21-5p. Yes Overexpression of NBAT1 inhibits the proliferation, migration, and invasion abilities of EC cells and facilitated apoptosis. 35912140 NR4A1AS LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck tumor tissue regulation[Upregulates miR-221 ] CCK8//qRT-PCR In this study, we observed that NR4A1AS was upregulated in tumor tissue samples of OSCC, and its high expression levels were significantly correlated with poor survival in patients with OSCC. Moreover, we also propose that miR-221 is modulated by NR4A1AS through demethylation and the upregulation of NR4A1AS or miR-221 promotes the proliferation of OSCC cells, which suggests that anti-NR4A1AS might be a perspective approach for the therapy of OSCC. In this study, we observed that NR4A1AS was upregulated in tumor tissue samples of OSCC, and its high expression levels were significantly correlated with poor survival in patients with OSCC. Yes In addition, overexpression of NR4A1AS or miR-221 increased the proliferation rate of OSCC cells. 32753947 MYLK-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissues and cell lines regulation[MYLK-AS1/ miR-424-5p/E2F7 signaling pathway] Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay//Colony Formation Assay MYLK-AS1 up-regulation was detected in the HCC tumor tissues and cell lines associated with the enhancement of the angiogenesis and tumor progression. MYLK-AS1 and E2F7 are closely related to some malignant clinicopathological features and prognosis of HCC, thus the MYLK-AS1/ miR-424-5p/E2F7 signaling pathway might represent a promising treatment strategy to combat HCC. Yes The down-regulation of MYLK-AS1 reversed the effects on angiogenesis, proliferation, invasion and metastasis in the HCC cells and in vivo. 33168027 METTL3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cancer stem cells Regulation(TGFBR1/SMAD2/SMAD3 pathway) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay//ChIP Based on an integrative analysis of The Cancer Genome Atlas database, we identified lncRNA-RNA Component of Mitochondrial RNA Processing Endoribonuclease (RMRP) as one of the most highly upregulated lncRNAs that are associated with poor survival in NSCLC. Furthermore, N(6)-methyladenosine (m6A) was highly enriched within RMRP and enhanced its RNA stability. In vitro and in vivo experiments showed that RMRP promoted NSCLC cell proliferation, invasion, and migration. In terms of mechanism, RMRP recruited YBX1 to the TGFBR1 promotor region, leading to upregulation of the transcription of TGFBR1. The TGFBR1/SMAD2/SMAD3 pathway was also regulated by RMRP. In addition, RMRP promoted the cancer stem cells properties and epithelial mesenchymal transition, which promote the resistance to radiation therapy and cisplatin. Clinical data further confirmed a positive correlation between RMRP and TGFBR1. Based on an integrative analysis of The Cancer Genome Atlas database, we identified lncRNA-RNA Component of Mitochondrial RNA Processing Endoribonuclease (RMRP) as one of the most highly upregulated lncRNAs that are associated with poor survival in NSCLC. Yes In vitro and in vivo experiments showed that RMRP promoted NSCLC cell proliferation, invasion, and migration. In terms of mechanism, RMRP recruited YBX1 to the TGFBR1 promotor region, leading to upregulation of the transcription of TGFBR1. 34628486 METTL3 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-107/PER3 axis) colony Formation Assay//TUNEL//Western Blot//ISH//Wound Healing Assay//Tunel//Colony Formation Assay//qRT-PCR//RIP//FISH//IF//MSP//PCR//IP//IHC//Invasion Assay//ChIP RUNX3, circMETTL3, and PER3 were diminished while miR-107 was elevated in CRC tissues and cells. Mechanistically, RUNX3 bound to METTL3 promoter and activated circMETTL3 transcription. circMETTL3 directly bound with miR-107 which targeted PER3. circMETTL3/miR-107 regulated CRC cell proliferation and invasion via PER3. CircMETTL3, transcriptionally activated by RUNX3, restrains CRC development and metastasis via acting as a miR-107 sponge to regulate PER3 signaling. Low levels of RUNX3 and circMETTL3 correlated with poor prognosis of CRC. Yes Overexpression of RUNX3, circMETTL3, or PER3 suppressed while miR-107 mimics promoted, CRC cell proliferation and invasion, as well as tumor growth and metastasis in vivo. 35710754 hsa_circ_0020850 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues regulation[miR-195-5p/IRS2 Axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay circ_0020850 expression was enhanced in lung adenocarcinoma tissues and cells. circ_0020850 knockdown repressed lung adenocarcinoma cell proliferation, migration and invasion and promoted apoptosis via regulating miR-195-5p and IRS2. Yes circ_0020850 silence suppressed cell proliferation, migration and invasion and facilitated apoptosis. circ_0020850 down-regulation decreased lung adenocarcinoma xenograft tumor growth. 33149675 NBR2 LncRNA Homo sapiens Hepatoblastoma hepatoblastoma tissue samples Interaction(miR-22/TCF7 axis) Transfection//Wound Healing Assay//Immunoblotting//FISH//MTT//Luciferase Report Assay//Cell Apoptosis Assay//Transwell Assay The expression of NBR2 is significantly increased within hepatoblastoma tissue samples; moreover, under incubation with 0 mM glucose (glucose starvation), NBR2 expression is significantly upregulated. NBR2 silencing in hepatoblastoma cells also decreased TCF7 mRNA expression and TCF7 protein levels, as well as the protein levels of the cell cycle, glucose entrapment, and EMT markers. miR-22 is directly bound to both NBR2 and TCF7; lncRNA NBR2 counteracted miR-22-mediated repression on TCF7 via acting as a ceRNA. The effects of NBR2 silencing on TCF7 expression, hepatoblastoma cell phenotype, and cell cycle, glucose entrapment, and EMT markers were all significantly reversed by miR-22 inhibition. Yes NBR2 silencing not only inhibited hepatoblastoma cell viability, invasion, and migration under normal culture condition but also promoted the cell apoptosis under glucose starvation. 33651649 NBR2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues, CD133+ cells Regulation(Notch1/TGF-β1) qRT-PCR//Western Blot NBR2 was significantly downregulated in NSCLC tissues than that in non-cancer tissues of NSCLC patients, and low expression levels of NBR2 predicted poor survival. TGF-β1 was significantly upregulated in NSCLC tissues than that in non-cancer tissues, and was inversely correlated with NBR2.Overexpression of NBR2 downregulated TGF-β1, while overexpression of TGF-β1 did not affect the expression of NBR2. Mechanically, NBR2 interacted with Notch1 protein to inhibit its expression, thereby inhibiting the expression of TGF-β1 and further affecting the proportion of CD133+ cells. NBR2 was significantly downregulated in NSCLC tissues than that in non-cancer tissues of NSCLC patients, and low expression levels of NBR2 predicted poor survival. Yes Overexpression of NBR2 inhibited, while overexpression of TGF-β1 promoted NSCLC cell stemness. 35909269 Nron LncRNA Mus musculus Periodontitis osteoclastic-specific Nron knockout mice and osteoclastic-specific Nron transgenic mice Regulation(NKRF/Nfatc1) RNA-seq//Western Blot Interestingly, we recently found that the lncRNA Nron is negatively correlated with alveolar bone resorption in periodontitis model. Mechanistically, Nron was found to effectively promote the nuclear transport of NF-κb repressing factor (NKRF). In addition, NKRF in the nucleus significantly repressed the transcription of Nfatc1, which is a major NF-κb signaling molecule. Yes Nron effectively inhibited osteoclastogenesis and alveolar bone resorption. 34157883 MYLK-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(EZH2/LATS2) ChIP//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//IHC//Transwell Assay Results revealed that MYLK-AS1 showed an upregulated level in GC. Through in-depth mechanism exploration, MYLK-AS1 was uncovered to bind with wnhancer of zeste homolog 2 (EZH2), an epigenetic inhibitor, to inhibit the level of Large Tumor Suppressor 2 (LATS2), thereby exerting carcinogenicity. It was worth mentioning that upregulated MYLK-AS1 caused the unfavorable clinical outcome in GC patients. Yes Functional assays indicated that MYLK-AS1 silencing retarded the proliferation, cell cycle, migration, and invasion in GC. Besides, in vivo assay validated that MYLK-AS1 deficiency also restrained tumor growth. 34181498 NBPF4 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(ZFP36/EZH2 ) CCK8//qRT-PCR//Western Blot Initially, we identified that NBPF4 was downregulated in CRC tissues and cell lines.Our results demonstrated that NBPF4 downregulated EZH2 and stabilized itself by binding to ZFP36, thus escaping from inhibition by miR-17-3p, which allowed mitigation of CRC through inhibition of ETFA. Yes Furthermore, we observed that NBPF4 decreased tumorigenesis in both in vitro and in vivo models. 34405537 NRON LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Interaction[lncRNA snaR] CCK8//qRT-PCR Interestingly, our study observed the down-regulation of NRON in triple-negative breast cancer (TNBC) tissues compared with paired adjacent healthy tissues. The snaR overexpression resulted in promoted cancer cell proliferation but did not significantly affect NRON expression. NRON overexpression inhibited cancer cell proliferation and down-regulated snaR. The snaR overexpression reduced the effects of NRON overexpression. We therefore conclude that NRON may down-regulate lncRNA snaR to inhibit cancer cell proliferation in TNBC. Yes NRON overexpression inhibited cancer cell proliferation and down-regulated snaR. 30996114 NRON LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues and cell lines Expression[highly expressed] qRT-PCR The expression of NRON was significantly upregulated in BC specimens and cell lines compared with paired adjacent normal tissues and normal cell lines. The upregulation of NRON in bladder cancer patients was significantly associated with the depth of bladder tumor invasion and poor prognosis. Yes Knockdown of NRON inhibited BC cells proliferation, migration, invasion and tumorigenicity. 32194786 NRON LncRNA Homo sapiens Breast Neoplasms Breast cancer tissue regulation[miR-302b/SRSF2 axis] qRT-PCR Our results showed that the expression of lncRNA NRON was significantly downregulated in breast cancer tissues.Overall, we performed a comprehensive analysis to indicate that the lncRNA NRON/miR-302b/SRSF2 axis plays an important role in breast cancer. Yes Overexpression of lncRNA NRON significantly inhibited proliferation and invasion in breast cancer cell lines. Knockdown of lncRNA NRON promoted breast cancer development. 32913541 NRON LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tumors Expression [highly expressed] qRT-PCR//FISH We observed that lncNRON was upregulated in GC tissues and cell lines, and high lncNRON expression was associated with malignant features and poor prognosis in GC patients. LncNRON was found to promote the proliferation and tumorigenicity of GC cells. Mechanistically, lncNRON exerted its oncogenic functions by binding to the N6-methyladenosine eraser ALKHB5 and mediating Nanog mRNA decay. LncNRON expression is upregulated in GC and is relevant to the prognosis of patients. Yes LncNRON was found to promote the proliferation and tumorigenicity of GC cells. 34659574 METTL3 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cell lines Interaction(miR-34c-3p) colony Formation Assay//Western Blot//Wound Healing Assay//Proliferation Assay//qRT-PCR//Luciferase Report Assay//PCR//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//IF In this study, we investigate the pathological role and the underlying mechanism of the m6A methylated RNA level and its major methyltransferase METTL3 in the TNBC progression. We found that the m6A methylated RNA was dramatically decreased in TNBC tissues and cell lines. Functionally, we demonstrated that METTL3 inhibits the proliferation, migration, and invasion ability of TNBC cells. Moreover, we found METTL3 is repressed by miR-34c-3p in TNBC cells. On the mechanism, we found that circMETTL3 could act as a sponge for miR-34c-3p and inhibits cell proliferation, invasion, tumor growth and metastasis by up-regulating the expression of miR-34c-3p target gene METTL3. Yes Functionally, we demonstrated that METTL3 inhibits the proliferation, migration, and invasion ability of TNBC cells. Moreover, we found METTL3 is repressed by miR-34c-3p in TNBC cells. On the mechanism, we found that circMETTL3 could act as a sponge for miR-34c-3p and inhibits cell proliferation, invasion, tumor growth and metastasis by up-regulating the expression of miR-34c-3p target gene METTL3. 35004298 NRSN2-AS1 LncRNA Homo sapiens Ovarian Neoplasms OV cells and tissues Interaction(miR-744-5p/PRKX axis) In Vivo Experiment//CCK8//qRT-PCR//FISH//Colony Formation Assay//EdU Staining//Transwell Assay According to the results of qantitative real-time polymerase chain reaction, NRSN2-AS1 displayed the remarkably high expression in OV cells, in contrast to human ovarian epithelial cells. Based on online database, the expression level of NRSN2-AS1 was significantly higher in OV tissues than that in normal ovarian tissues.Moreover, mechanism analysis unveiled that NRSN2-AS1 functioned as a miR-744-5p sponge to regulate PRKX expression in OV cells. The results of TOP/FOP flash and western blot assays suggested that NRSN2-AS1/miR-744-5p/PRKX axis modulated the activity of Wnt/β-catenin signaling pathway. Yes The data from functional experiments indicated that NRSN2-AS1 knockdown inhibited OV cell malignant behaviors in vitro and OV tumor growth in vivo. 34791059 circXPO1 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues interaction[IGF2BP1] qRT-PCR//MTT//RIP//Western Blot circXPO1 was highly expressed in LUAD tissues compared with paired adjacent non-tumor tissues, and high circXPO1 expression correlated with worse overall survival. Mechanically, circXPO1 could bind with IGF2BP1 and enhance CTNNB1 mRNA stability, and subsequently promote LUAD progression. circXPO1 was highly expressed in LUAD tissues compared with paired adjacent non-tumor tissues, and high circXPO1 expression correlated with worse overall survival. Yes In a LUAD patient-derived xenograft model, intratumoural injection of cholesterol-conjugated siRNA specifically targeting circXPO1 efficiently suppressed tumor growth. 33268793 hsa_circ_002178 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD cancer tissues,cell lines interaction[promote PDL1/PD1 expression] Flow Cytometry//qRT-PCR//RIP//Western Blot Among them, has-circRNA-002178 was further confirmed to be upregulated in the LUAD tissues, and LUAD cancer cells.Taken together, our study revealed that circRNA-002178 could act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma. Yes Subsequently, we also found has-circRNA-002178 could enhance PDL1 expression via sponging miR-34 in cancer cells to induce T-cell exhaustion. 31949130 NBDY LncRNA Homo sapiens Thyroid Neoplasms Expression[highly expressed] CCK8//qRT-PCR//Cell Cycle Assay The data suggested that the expression of LINC01420 was significantly higher in TC tissues, compared with that in normal tissue samples (Fig. 1A). Yes Furthermore, the exact role of LINC01420 in TC was explored by performing a loss-of-function assay, which revealed that the knockdown of LINC01420 inhibited TC cell proliferation and cell cycle progression. 31897152 NRSN2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Interaction(SOX2/NRSN2-AS1/PGK1 ) RNA Pull-Down//ChIP//Western Blot//Co-IP//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay//Transwell Assay Our analysis of clinical data revealed that NRSN2-AS1 was upregulated in ESCC tissues and negatively correlated with patient survival. Luciferase reporter assays and chromatin immunoprecipitation assays demonstrated that NRSN2-AS1 is transcribed by SOX2. Mechanistically, NRSN2-AS1 can bind to phosphoglycerate kinase 1 (PGK1) and upregulate its protein levels by inhibiting its ubiquitination. Our analysis of clinical data revealed that NRSN2-AS1 was upregulated in ESCC tissues and negatively correlated with patient survival. Yes In vitro functional experiments showed that NRSN2-AS1 can promote ESCC cell proliferation, migration, and invasion. 35715622 hsa_circ_0001588 CircRNA Homo sapiens Glioblastoma GBM tissues and human gliomas cells Interaction(miR-211-5p/YY1 signaling) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression of circ_0001588 is markedly up-regulated in GBM tissues and human gliomas cells.Mechanistically, circ_0001588 locates in the cytoplasm, which is directly bound with miR-211-5p. Furthermore, circ_0001588 can positively regulate YY1 via sponging miR-211-5p. Additionally, increased expression of circ_0001588 is positively relevant with poor survival in GBM patients. Yes The down-regulation of circ_0001588 distinctly inhibits the proliferation, migration and invasion of GBM in vitro, as well as tumor growth in vivo. Moreover, knockdown of circ_0001588 reduces the tumor volume and weight, enhances the relative IHC staining index of E-cadherin and decreases the relative IHC staining index of Ki-67, Yin Yang 1 (YY1) and vinmentin in vivo. 34105224 hsa_circ_0006168 CircRNA Homo sapiens Glioblastoma human GBM tissues and cells Interaction(miR-628-5p/IGF1R ceRNA axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay hsa_circ_0006168 and IGF1R were upregulated, and miR-628-5p was downregulated in human GBM tissues and cells. Mechanically, hsa_circ_0006168 targeted and sponged miR-628-5p, and IFG1R was a novel target for miR-628-5p. Inhibiting miR-628-5p could abrogate in vitro role of hsa_circ_0006168 knockdown, and similarly IGF1R upregulation counteracted miR-628-5p role. Yes Functionally, blocking hsa_circ_0006168 and overexpressing miR-628-5p suppressed cell proliferation, migration, invasion, and expression of Vimentin and Snail (mesenchymal markers) in A172 and LN229 cells, accompanied with increased E-cadherin (epithelial marker), decreased colony formation, and promoted apoptosis rate. Silencing miR-628-5p counteracted the suppression of hsa_circ_0006168 deficiency on these behaviors, and restoring IGF1R blocked miR-628-5p-mediated inhibition as well. More importantly, hsa_circ_0006168 knockdown could delay xenograft tumor growth in vivo and lower Ras and phosphorylated Erk1/2 expression in vitro and in vivo. 34024251 NRAV LncRNA Homo sapiens Carcinoma, Hepatocellular Interaction(MiR-199a-3p/CISD2 axis/ Wnt/β-catenin signaling pathway) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay we found that NRAV plays an upmodulating role in HCC cells and tissues, and patients with high NRAV expression showed a poor prognosis. The dual-luciferase assay showed that miR-199a-3p is not only a target for NRAV but also interacts with the 3' UTR of CISD2 in HCC cells. MiR-199a-3p/CISD2 axis performs a function in NRAV-mediated cell behavior regulation. NRAV may trigger the Wnt/β-catenin signaling via the modulation of the miR-199a-3p/CISD2 axis in HCC. we found that NRAV plays an upmodulating role in HCC cells and tissues, and patients with high NRAV expression showed a poor prognosis. Yes Findings illustrated that the overexpression of NRAV enhanced the HCC cell viability, proliferation and invasion, whereas they were inhibited significantly by down expression of NRAV. 35436415 NSD2 CircRNA Homo sapiens Endometrial Neoplasms endometrial cancer tissues interaction[miR-646/NPM1 pathway] qRT-PCR//Western Blot//PCR//IF CircWHSC1 expression was increased in endometrial cancer tissues.CircWHSC1 promotes endometrial cancer development through sponging miR-646 and targeting NPM1. Yes CircWHSC1 overexpression promoted the proliferation, migration and invasion of endometrial cancer cells and decreased apoptosis. CircWHSC1 knockdown had the opposite effect. 32378344 NBR2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[Notch1 pathway] CCK8//qRT-PCR//Western Blot The expression of lncRNA NBR2 was decreased in NSCLC patients tissues, and the NSCLC patients in the NBR2 low expression group showed a poor prognosis.Overexpression of NBR2 suppressed the viability and migration of NSCLC cells and the expression of Notch1 and EMT-related genes in AsPC-1 cells. Simultaneous overexpression of NBR2 and Notch1 could reverse the inhibitory effect of NBR2 on proliferation and migration of NSCLC cells. The expression of lncRNA NBR2 was decreased in NSCLC patients tissues, and the NSCLC patients in the NBR2 low expression group showed a poor prognosis. Meanwhile, the expression of NBR2 in patients with NSCLC was correlated with tumor size. Yes Overexpression of NBR2 suppressed the viability and migration of NSCLC cells and the expression of Notch1 and EMT-related genes in AsPC-1 cells. Simultaneous overexpression of NBR2 and Notch1 could reverse the inhibitory effect of NBR2 on proliferation and migration of NSCLC cells. 31599420 NR4A1AS LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction[NR4A1] Western Blot//Invasion Assay//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//ChIP We first identified an antisense lncRNA of NR4A1 that was up-regulated in CRC tissues and cells with rapid amplification of cDNA ends (RACE), and designated it as NR4A1AS.Thus, we conclude that NR4A1AS up-regulates NR4A1 expression by forming RNA-RNA complexes and blocking UPF1-mediated mRNA destabilization, and it functions in tumor growth and metastasis of CRC cells at least partly through regulating NR4A1, suggesting that NR4A1AS might be as a potential target for RNA-based anti-CRC drug studies. Yes Moreover, depletion of NR4A1AS was found to mimic the effect of NR4A1 knockdown, specifically by suppressing cell proliferation, migration and invasion, and inducing apoptosis and cell cycle arrest. 31253658 MYLK-AS1 LncRNA Homo sapiens gallbladder carcinoma 120 pairs of GBC tissues Interaction(miR-217/EZH2) qRT-PCR//Transfection//Luciferase Report Assay//Western Blot Here, we demonstrated that MYLK-AS1 was significantly upregulated and correlated with a poor prognosis and poor clinical characteristics in GBC. Mechanistically, MYLK-AS1 functioned as an efficient miR-217 sponge, thereby releasing the inhibition of enhancer of zeste 2 polycomb repressive complex 2 (EZH2) subunit expression. MYLK-AS1 promoted GBC cell proliferation and resistance to gemcitabine by upregulating EZH2 expression, and EZH2 was confirmed as a direct target of miR-217. Here, we demonstrated that MYLK-AS1 was significantly upregulated and correlated with a poor prognosis and poor clinical characteristics in GBC. Yes Furthermore, the forced expression of MYLK-AS1 significantly promoted GBC cell proliferation and resistance to gemcitabine in vitro. 34393514 MYLK-AS1 LncRNA Homo sapiens Wilms Tumor nephroblastoma tissues and cells Interaction(TCF7L2/CCNE1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Microarray//Colony Formation Assay//ChIP After nephroblastoma tissue sample collection, RT-qPCR confirmed the upregulated expression of MYLK-AS1 and CCNE1 in nephroblastoma tissues and cells. RNA binding protein immunoprecipitation, chromatin immunoprecipitation, and dual-luciferase reporter gene assay were employed to determine the relationship among MYLK-AS1, TCF7L2, and CCNE1, which validated that transcription factor 7-like 2 (TCF7L2) could specifically bind to MYLK-AS1 and TCF7L2 could positively promote CCNE1. Kaplan-Meier curve exhibited that patients with elevated CCNE1 had lower overall survival rate in follow-up study. Yes silencing of MYLK-AS1 exerts suppressive role in the tumorigenic ability of nephroblastoma cells in vivo. 33438217 circATG7 CircRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells Interaction(miR-766-5p/ATG7) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//ISH//qRT-PCR//RIP//IF//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Herein, we demonstrated that autophagy-associated circRNA circ-autophagy related 7 (circATG7) was elevated in PC tissues compared to adjacent tissues, and in PC cells treated with EBSS and hypoxia. CircATG7 is located in the cell cytoplasm and nucleus. Cytoplasmic circATG7 sponged miR-766-5p and decreased its expression, and increased the expression of ATG7, a target gene of miR-766-5p. Nuclear circATG7 acted as a scaffold to increase the interaction between the human antigen R protein and ATG7 mRNA and enhanced ATG mRNA stability. Furthermore, we demonstrated that circATG7 regulates PC cell proliferation and metastasis in vivo via ATG7-dependent autophagy. circATG7 expression was positively associated with tumor diameter and lymph node invasion in patients with PC. Yes circATG7 overexpression promoted PC cell proliferation, mobility, and autophagy in vitro, while circATG7 knockdown induced the opposite effects. ATG7 inhibition attenuated the effects of circATG7 on the biological functions of PC cells. 35288538 circSKA3 CircRNA Homo sapiens Glioblastoma GBM tissues Interaction(miR-1) CCK8//qRT-PCR//Transfection We found that circSKA3 was upregulated in GBM and inversely correlated with miR-1 across GBM tissues. In GBM cells, overexpression of circSKA3 increased the methylation of miR-1 gene and decreased the expression of miR-1. High expression levels of circSKA3 and low expression levels of miR-1 were significantly correlated with the poor survival of GBM patients. Yes CCK-8 assay showed that overexpression of circSKA3 reduced the inhibitory effects of miR-1 on cell proliferation. 33500664 NBR2 LncRNA Homo sapiens Colorectal Neoplasms CRC tumors Expression Western Blot//Migration Assay//CCK8//qRT-PCR//Transwell Assay We found that the lncRNA NBR2, TNF-α, and HLA-DR were downregulated, and Arg-1, CD163, CD206, and IL-4 were upregulated in CRC tumors. Therefore, the lncRNA NBR2 suppressed the progression of colorectal cancer in vitro and in vivo by regulating TAM polarization. Yes M1 polarization was activated and M2 polarization was suppressed in NBR2-overexpressed macrophages, accompanied by increased production of inflammatory factors, decreased proliferation, and inhibited migration ability in the co-culture system of HCT-116 cells (SW480 cells) and NBR2-overexpressed macrophages. The promoted proliferation and migration were observed in the co-culture system of HCT-116 cells (SW480 cells) and NBR2-knockdown macrophages. The tumor growth of both HCT-116 cells and SW480 cells in the xenograft model was suppressed by co-planting NBR2-overexpressed macrophages and was facilitated by the co-planting of NBR2-knockdown macrophages. 34506209 NBR2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[ERK and JNK pathways] Western Blot//CCK8//qRT-PCR//Cell Cycle Assay//Transwell Assay We found that HCC cases with lower NBR2 expression had significantly worse overall survival than those with higher NBR2 expression in advanced patients.Taken together, NBR2 suppressed autophagy-induced cell proliferation at least partly through ERK and JNK pathways. We found that HCC cases with lower NBR2 expression had significantly worse overall survival than those with higher NBR2 expression in advanced patients. Yes Besides, NBR2 inhibited the proliferation, invasion, and migration of liver cancer cells. 33378941 NRAD1 LncRNA Homo sapiens Intervertebral Disc Degeneration IDD tissue and NP cells Interaction(miR‑205‑3p/Wnt/β‑catenin axis) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay The results showed that LINC00284 expression was upregulated in IDD tissue and IL?1β?induced NP cells. LINC00284 was also shown to be a target of microRNA (miR)‑205‑3p, and there was a negative correlation between LINC00284 and miR‑205‑3p levels in IDD tissue. Additionally, LINC00284 knockdown or miR‑205‑3p upregulation resulted in inhibition of Wnt/β‑catenin signaling and subsequent degradation of the ECM. Yes LINC00284 knockdown resulted in an increase in IL‑1β‑induced NP cell proliferation, a decrease in apoptosis and matrix metalloproteinase‑3 expression and an increase in expression of extracellular matrix (ECM) markers aggrecan and collagen II. In vivo experiments and histomorphometric analysis confirmed the protective effect of LINC00284 knockdown in IDD. 35322864 circCDC45 CircRNA Homo sapiens Glioblastoma GBM tissues and cells Interaction(miR-485-5p/CSF-1 axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay The expression of circCDC45 and CSF-1 was elevated in GBM tissues and cells, while the expression of miR-485-5p was declined. In mechanism, circCDC45 positively regulated the expression of CSF-1 by targeting miR-485-5p. Inhibition of miR-485-5p reversed the biological effects caused by circCDC45 downregulation in GBM cells. Yes Downregulation of circCDC45 or CSF-1 blocked GBM cell proliferation, invasion and migration as well as tumor growth in vivo. 34627193 NRAD1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(miR-3127-5p-E2F7 axis) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//IHC//Bioinformatics Analysis We found that LINC00284 expression was remarkably increased in PTC tissues and its overexpression was closely correlated with larger tumor size. In addition, silencing LINC00284 could effectively attenuate PTC cell proliferation, induce apoptosis and G1 arrest in vitro, as well as suppress tumorigenesis in mouse xenografts. Mechanistic investigations showed that LINC00284 acted as a competing endogenous RNA (ceRNA) for miR-3127-5p, thus resulting in the disinhibition of its endogenous target E2F7. Yes In short, our findings indicated that LINC00284-miR-3127-5p-E2F7 axis exerted oncogenic properties in PTC and may offer a new promising target for the diagnosis and therapy of PTC. 34226533 MYLK-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular regulation[EGFR/HER2-ERK1/2 signaling pathway] qRT-PCR In addition, MYLK-AS1 is overexpressed in HCC patients and negatively correlated with HCC prognosis. Thus, MYLK-AS1 is an upstream regulator of EGFR/HER2, and acts as an oncogene, suggesting an additional target for cancer therapeutics. Yes MYLK-AS1 increases hepatocellular carcinoma (HCC) cell proliferation, migration, and invasion in vitro. 32398965 NBR2 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Regulation[regulating Notch1 signaling] RNA Pull-Down//Western Blot//Wound Healing Assay//Tunel//CCK8//qRT-PCR//RIP//Invasion Assay In our study, we found that NBR2 expression was downregulated in osteosarcoma tissues, and osteosarcoma cases with lower NBR2 expression exhibited a shorter overall survival time compared with those with higher NBR2 expression. Furthermore, RNA-binding protein immunoprecipitation assays confirmed that NBR2 directly binds to Notch1 protein. Furthermore, overexpression of Notch1 in NBR2-overexpressing osteosarcoma cells reversed the effects of NBR2 on cell proliferation, invasion, migration, and epithelial-mesenchymal transition.NBR2 overexpression also suppressed the messenger RNA (mRNA) expression of Notch1, N-cadherin, and vimentin and increased the mRNA expression of E-cadherin in the tumor tissues. In our study, we found that NBR2 expression was downregulated in osteosarcoma tissues, and osteosarcoma cases with lower NBR2 expression exhibited a shorter overall survival time compared with those with higher NBR2 expression. Yes NBR2 overexpression inhibited osteosarcoma cell proliferation, invasion, and migration but did not increase apoptosis.The in vivo results showed that NBR2 overexpression inhibited tumor growth in nude mice that were inoculated with osteosarcoma cells. 30187965 NRAD1 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer cell lines Interaction(miR-30d-5p/ADAM12/ Notch signaling pathway) In Vivo Experiment//RNA Pull-Down//Transfection//Flow Cytometry//FISH//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis In parallel with the microarray data from GSE66783, LINC00284 was observed to be expressed at high levels in thyroid cancer cell lines. Mechanistically, using dual-luciferase reporter, RNA pull-down, and RNA immunoprecipitation (RIP) assays, LINC00284 was identified to competitively bind to microRNA-30d-5p (miR-30d-5p), which was observed to be expressed at low levels in thyroid cancer tissues and cells and directly targets the oncogene a disintegrin and metalloproteinase 12 (ADAM12). Overexpression of miR-30d-5p exerted tumor-suppressive effects on the malignant activity of thyroid cancer cells, changes that were reversed by LINC00284 overexpression or ADAM12 overexpression. Furthermore, LINC00284 activated the Notch signaling pathway by competitively binding to miR-30d-5p and increasing the expression of ADAM12. Yes Moreover, loss-of-function experiments revealed that the downregulation of LINC00284 reduced aldehyde dehydrogenase (ALDH) activity and thyroid cancer cell proliferation, colony formation, and invasiveness, which promoted cell apoptosis. 34490077 NRAD1 LncRNA Homo sapiens Colorectal Neoplasms RC tissues and colorectal cancer cell lines Interaction(miR-27a/c-Met regulatory axis) CCK8//qRT-PCR//IHC Our findings reveal that Linc00284 is upregulated in CRC tissues and colorectal cancer cell lines HCT116 and SW480 in comparison with corresponding para-carcinoma tissues and human fetal colonic mucosa cells FHC.Serum Linc00284 is increased, while miR-27a is decreased in CRC patients compared to healthy controls. Mechanistically, Linc00284 promotes c-Met expression by acting as miR-27a sponge, leading to the activation of downstream signaling pathways, thereby causing malignant phenotypes of CRC cells. High expression of Linc00284 in tumor tissues is associated with tumor metastasis and predicts a poor clinical outcome in CRC patients. Serum Linc00284 is increased, while miR-27a is decreased in CRC patients compared to healthy controls Yes Additionally, results in vitro and in vivo experiments suggest that Linc00284 silencing significantly suppresses CRC cell proliferation and/or invasion. 34050266 NRAD1 LncRNA Homo sapiens Lung Neoplasms LC tissues & cells Interaction(miR-205-3p/c-Met Axis) Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay Data showed that Linc00284 was significantly upregulated in LC tissues compared to adjacent normal lung tissues and predicted poor prognosis in patients with LC. In vitro, Linc00284 was highly expressed in LC cells and was mainly localized in the cytoplasm. Data showed that Linc00284 was significantly upregulated in LC tissues compared to adjacent normal lung tissues and predicted poor prognosis in patients with LC. Yes In vitro, Linc00284 was highly expressed in LC cells and was mainly localized in the cytoplasm.the in vivo results indicated that Linc00284 knockdown markedly suppressed tumor growth. 34616424 NBR2 LncRNA Homo sapiens Thyroid Neoplasms TC tissues regulation[AMPK Signaling] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Cell Apoptosis Assay//cell invasion assay Here, we show that NBR2 expression is down-regulated in TC tissues and associated with histologic subtypes of TC.Therefore, such data indicated that NBR2 acted as a tumor suppressor of thyroid cancers associated with enhancing the AMPK signaling and NBR2 may be a potential biomarker and therapeutic target for thyroid cancers. Yes While NBR2 silencing significantly enhanced the malignancy of BCPAP cells by increasing cell proliferation, clonogenicity, wound healing, and invasion as well as tumor growth in vivo, and decreasing spontaneous apoptosis, NBR2 over-expression had opposite effects in BHT101 cells. 32596161 NRAV LncRNA Homo sapiens Carcinoma, Pancreatic Ductal PDAC cells and tissues Interaction(miR-299-3p) In Vivo Experiment//IHC//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression level of lncRNA NRAV was higher in both tumor tissues and cell lines of PDAC and was negatively associated with the clinical survival of PDAC patients. Finally, NRAV was performed as a molecular sponge of miR-299-3p. Moreover, overexpression of miR-299-3p could reverse the promoting effects of NRAV on cell proliferation and metastasis of PDAC cells. The expression level of lncRNA NRAV was higher in both tumor tissues and cell lines of PDAC and was negatively associated with the clinical survival of PDAC patients. Yes Functionally, overexpression of NRAV promoted cell proliferation and metastasis of PDAC cells, while knockdown of NRAV reversed these effects. 36188725 NBR2 LncRNA Homo sapiens Multiple Myeloma MM cell lines Interaction(NBR2/miR-561-5p/DLC1 axis) qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis NBR2 regulated the biological behavior of MM cells and the activation of the AMPK/mTOR signaling pathway by targeting miR-561-5p. DLC1 was the target gene of miR-561-5p and the protein expression of DLC1 was regulated by the NBR2/miR-561-5p axis. Yes The upregulation of NBR2 in MM cell lines induced a decrease in the viability, proliferation capacity, glycolysis, and lactic acid production, and an increase in apoptosis of MM cells. 35951458 circABCB10 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues,cells line Expression[highly expressed] CCK8//qPCR//Western Blot Circ-ABCB10 expression was elevated in all the ccRCC cell lines compared with the normal kidney cells line. In addition, circ-ABCB10 was up-regulated in tumor tissues compared with paired adjacent tissues. In addition, circ-ABCB10 was up-regulated in tumor tissues compared with paired adjacent tissues, and its high expression correlated with the advanced pathological grade and the tumor node metastasis stage as well as independently predicting worse overall survival in ccRCC patients. Yes A498 cell proliferation was enhanced in the Circ-ABCB10(+) group compared with the NC(+) group, while it was inhibited in the Circ-ABCB10(-) group compared with the NC (-) group; and A498 cell apoptosis was repressed in the Circ-ABCB10(+) group than the NC(+) group, but was promoted in the Circ-ABCB10(-) group compared with the NC(-) group. 31106654 NSD2 CircRNA Homo sapiens Lung Neoplasms NSCLC cells and tissues Interaction(miR-7/TAB2) cell invasion assay//Western Blot//Transfection//Wound Healing Assay//Proliferation Assay//PCR//Cell Proliferation Assay//Invasion Assay//IF Our data showed that circ-WHSC1 was highly expressed in NSCLC cells and tissues. Through bioinformatic analysis and functional experiments, we showed that circ-WHSC1 could act as a sponge for micro-RNA-7 (miR-7) and regulate the expression of TAB2 (TGF-beta activated kinase one binding protein two). Inhibition of the circ-WHSC1/miR-7/TAB2 pathway could effectively attenuate lung cancer progression. Yes Both in vitro and in vivo experiments showed that circ-WHSC1 promoted NSCLC proliferation. circ-WHSC1 also promoted the migration and invasion of lung cancer cells. 34551195 MEG8 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tumor tissues and cells Interaction(miR-495-3p/G3BP1 axis) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//IHC//ChIP At first, we found that MEG8 expression was increased in ccRCC tumor tissues and cells. Subsequently, we utilized bioinformatics analysis, ChIP, and luciferase assays, and we found that PLAG1 could transcriptionally regulate MEG8 in ccRCC cells. Furthermore, MEG8 promoted G3BP1 expression to aggravate ccRCC tumorigenic properties through sponging miR-495-3p. Yes Next, we demonstrated that MEG8 knockdown suppressed cell viability, migration, and invasion in vitro and inhibited tumor growth in vivo. 35030351 circPUM1 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma cell lines and tissues Regulation[circPUM1/miR-326/Cyclin D1 and Bcl-2 axis] Western Blot//qPCR//Flow Cytometry//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay Here, it showed that circPUM1 is significantly upregulated in both lung adenocarcinoma cell lines and tissues.In summary, this present study revealed that circPUM1 functions as an oncogene to promote the tumorigenesis of lung adenocarcinoma through circPUM1/miR-326/Cyclin D1 and Bcl-2 axis. Yes Furthermore, silencing of circPUM1 impaired the proliferation, migration and invasion ability, and increased apoptosis in A549 cells. Nevertheless, overexpression of circPUM1 in SPC-A1 cells has the opposite effect. 30528736 circAGAP1 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Interaction(miR-15-5p/E2F3 Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Migration Assay//qRT-PCR//FISH//Luciferase Report Assay//IHC//Invasion Assay circAGAP1 (circ0058792) expression was significantly upregulated in ccRCC tissues compared to adjacent nontumor tissues. Mechanistic studies demonstrated that cytoplasmic circAGAP1 targeted miR-15-5p in an RNA-induced silencing complex. Additionally, miR-15-5p expression was downregulated in ccRCC. Luciferase reporter assays showed that E2F transcription factor 3 (E2F3) was a target of miR-15-5p, and upregulated E2F3 expression was positively correlated with circAGAP1 in ccRCC. Moreover, the expression of circAGAP1 was closely related to the tumor size, nuclear grade and clinical stage of ccRCC in patients. Yes NORAD overexpression repressed BC cell proliferation, migration, and invasion, whereas its knockdown produced the opposite effects. 33618745 circPPP6R3 CircRNA Homo sapiens Carcinoma, Renal Cell clear cell renal cell carcinoma (ccRCC) tissues and cell lines Interaction(miR-1238-3p/CD44 axis ) In Vivo Experiment//RNA Pull-Down//Luciferase Report Assay//RNA-seq Here we identified a novel circRNA, circPPP6R3, to be highly expressed both in clear cell renal cell carcinoma (ccRCC) tissues and cell lines based on analyzing high-throughput sequencing data and qRT-PCR analysis. Our study thus provided evidence that the regulatory network involving circPPP6R3/miR-1238-3p/CD44 axis might provide promising biomarkers as well as a therapeutic approach for ccRCC. Highly expressed circPPP6R3 was positively correlated with higher histological grade, T stage, and M stage as well as advanced clinical stage of ccRCC patients. Yes Functionally, knockdown of circPPP6R3 attenuated the proliferation, migration, and invasion of ccRCC cells whereas overexpression had the reverse effects. 34934046 circCHST15 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and RCC cell line Interaction(miR-125a-5p/EIF4EBP1 axis) In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//Microarray//Invasion Assay The expression of circCHST15 was higher in ccRCC tissues compared to healthy adjacent kidney tissue and higher in RCC cell lines compared to normal kidney cell lines. Mechanistically, we found that circCHST15 directly interacts with miR-125a-5p and acts as a microRNA sponge to regulate EIF4EBP1 expression. The level of circCHST15 was positively correlated with aggressive clinicopathological characteristics, and circCHST15 served as an independent prognostic indicator for overall survival and progression-free survival in patients with ccRCC after surgical resection. Yes Our in vivo and in vitro data indicate that circCHST15 promotes the proliferation, migration, and invasion of ccRCC cells. 34922539 circFLNA CircRNA Homo sapiens Glioblastoma clinical GBM samples and GBM cells Interaction(miR‑199‑3p) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay The results demonstrated that the expression levels of circFLNA were significantly upregulated in clinical GBM samples and GBM cells compared with adjacent healthy brain tissues and normal human astrocytes, respectively. Moreover, high circFLNA expression levels were associated with a worse prognosis in GBM. Yes The results of the Cell Counting Kit‑8 and Transwell assays revealed that circFLNA knockdown significantly inhibited the proliferative and invasive abilities of GBM cell lines.MicroRNA (miR)‑199‑3p was subsequently predicted to be target of circFLNA. 34498720 NBAT1 LncRNA Homo sapiens Lung Neoplasms cancer specimen and A549 cells Expression [lower expressed] CCK8//qRT-PCR//Flow Cytometry//Western Blot The expression level of lncRNA NBAT-1 in cancer specimen was remarkably lower than that in adjacent areas. Furthermore, the low expression of lncRNA NBAT-1 had a significant correlation with patient's tumor size, differentiation degree of tumor cells and lymph node metastasis. Yes The overexpression of lncRNA NBAT-1 could inhibit the proliferation and cell cycle, promote the apoptosis of A549 cells, and down-regulate the expression level of RAC1. 29687849 NBAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction(IGF2BP1/c-Myc) qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Western Blot Here, we found that the expression of NBAT1 was decreased in HCC tissues and cells; as well, the decreased expression of NBAT1 was also associated with tumor size and clinical TNM stages. NBAT1 bound to IGF2BP1 and inhibited the interaction between IGF2BP1 and c-Myc mRNA, thus suppressing the stability of c-Myc mRNA. Here, we found that the expression of NBAT1 was decreased in HCC tissues and cells; as well, the decreased expression of NBAT1 was also associated with tumor size and clinical TNM stages. Yes NBAT1 overexpression, both in vitro and in vivo studies, inhibited tumorigenesis through apoptosis augmentation and cell cycle blockade. 33387362 circRFX3 CircRNA Homo sapiens Glioblastoma GBM cell lines and clinical GBM tissues Interaction(miR-587/PDIA3/β-catenin axis.) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Bioinformatics Analysis//Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay We confirmed that the expression of circRFX3 was substantially increased in GBM cell lines and clinical GBM tissues. By performing dual-luciferase reporter gene and RNA pull-down assays, we verified that circRFX3 could sponge microRNA-587 (miR-587) to exercise its function as a competing endogenous RNA (ceRNA) in the development of GBM. In addition, PDIA3 was proven to be a downstream target of miR-587 and to regulate the Wnt/β-catenin pathway. Yes The results of a series of overexpression and knockdown assays indicated that circRFX3 could boost the proliferation, invasion, and migration of GBM cells. 34950658 NBAT1 LncRNA Homo sapiens Esophageal Neoplasms EC tissues Interaction[PKM2] CCK8//qRT-PCR//Western Blot Herein, we found that lncRNA NBAT-1 levels were lower in EC clinic tissues than in normal samples.Furthermore, a series of rescue experiments were performed to demonstrate that the role of lncRNA NBAT-1 in EC cell proliferation, cell growth and tumor glycolysis was partially dependent on the PKM2 protein, which is a key metabolic enzyme in tumor development. Taken together, our data illustrate a functional role for lncRNA NBAT-1 in metabolic reprogramming in EC cancer; thus, lncRNA NBAT-1 might be a potential clinical therapeutic target in EC patients. Herein, we found that lncRNA NBAT-1 levels were lower in EC clinic tissues than in normal samples, and lncRNA NBAT-1 expression was negatively associated with prognosis and TNM stage in EC patients Yes More importantly, in EC cancer cells, lncRNA NBAT-1 overexpression strongly inhibited cell proliferation, cell growth and tumor glycolysis. 31632565 circRPL23A CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cells Interaction(miR-1233/ACAT2) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Cell Cycle Assay//Transwell Assay Circ_RPL23A was lower expressed in ccRCC tissues and cells. MiR-1233 was a target of circ_RPL23A and direct targeted to ACAT2. Besides, circ_RPL23A exerted its anti-tumor effect by sponging miR-1233, and then relieved the inhibition effect of miR-1233 on ACAT2. Yes The elevated circ_RPL23A suppressed cell cycle progression, proliferation, migration and invasion but promoted apoptosis in ccRCC cells. 34036483 MELTF-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(YBX1/ANXA8 ) RNA Pull-Down//Luciferase Report Assay//ChIP In this study, an oncogenic lncRNA MELTF-AS1 was identified using systematic data analysis, screening, and verification. MELTF-AS1 was markedly upregulated in non-small cell lung cancer (NSCLC). Mechanistically, at the genome level, copy number amplification promoted MELTF-AS1 expression. At the transcriptional level, the transcription factor SP1 directly activated MELTF-AS1 transcription by binding to its promoter. Furthermore, MELTF-AS1 could directly bind and drive the phase separation of YBX1, which was an RNA-binding protein and involved in tumorigenesis, thus activating ANXA8 transcription and promoting tumorigenesis of NSCLC. Aberrant activation of ANXA8 and promotion of tumorigenesis have been found in a variety of tumors. High MELTF-AS1 levels were associated with advanced tumor-node-metastasis stage (TNM), high tumor size, and decreased survival time. Yes Functionally, MELTF-AS1 regulated cell proliferation and metastasis in vitro and in vivo. RNA sequencing analysis revealed that MELTF-AS1 knockdown specifically modulated genes associated with cell proliferation, apoptosis, and migration. 35508543 MEG8 LncRNA Homo sapiens Wilms Tumor WT tissues and cells Interaction(miR-23a-3p/CRK Axis) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay MEG8 and CRK expression was elevated, while miR-23a-3p expression was decreased in WT tissues and cells. . As to mechanism exploration, MEG8 could directly bind to miR-23a-3p and then miR-23a-3p targeted CRK. MEG8 was inversely correlated with miR-23a-3p and positively correlated with CRK in WT tissues. Meantime, miR-23a-3p was inversely correlated with CRK in WT tissues. . The histologic type, lymphatic metastasis, and National Wilms Tumor Study (NWTS) stage were associated with the expression of MEG8, miR-23a-3p, and CRK in WT patients. Yes MEG8 knockdown or miR-23a-3p overexpression restrained WT cells in cell viability, migration, and invasiveness in vitro. Additionally, MEG8 knockdown-mediated suppressive impacts on cell viability, migration, and invasiveness were reversed by overexpression of CRK or repression of miR-23a-3p in WT cells. 34518485 NUTM2A-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung The human A549 and NCI-H23 LUAD cells and the human BEAS2B lung epithelial cells Interaction(miR-590-5p/METTL3 axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay Reverse transcription-quantitative PCR analysis revealed that the expression levels of NUTM2A-AS1 were significantly upregulated, while those of miR-590-5p were significantly downregulated, in lung cancer cells compared with the control epithelial cells. It was determined that miR-590-5p could interact with METTL3, and further analysis of the expression levels of METTL3 in lung cancer cells demonstrated that METTL3 was significantly upregulated in NCI-H23 and A549 cells compared with the control cells. Yes NUTM2A-AS1 knockdown inhibited NCI-H23 cell viability and induced apoptosis by upregulating miR-590-5p expression. 34630705 NUTM2A-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction( miR-186-5p/KLF7-mediated Wnt/beta-catenin pathway) qRT-PCR As a result, lncRNA NUTM2A-AS1 and KLF7 profiles were heightened in the HCC tissues versus adjacent normal tissues, while miR-186-5p had the opposite expression tendency. The mechanistic studies revealed that miR-186-5p served as a common target of lncRNA NUTM2A-AS1 and KLF7. Up-regulation of lncRNA NUTM2A-AS1 was related to tumor size, advanced tumor stage, and lymph node metastasis of HCC patients. Yes Functionally, overexpression of lncRNA NUTM2A-AS1 heightened HCC cells' growth, invasion, EMT, and stemness and repressed their apoptosis by activating the Wnt/β-catenin pathway. In contrast, up-regulation of miR-186-5p or inhibition of KLF7 had reverse effects. In vivo, lncRNA NUTM2A-AS1 overexpression facilitated tumor growth and EMT, accompanied by declined miR-186-5p levels and enhanced KLF7 expression. 36242728 NBAT1 LncRNA Homo sapiens Glioma glioma tissues regulation[miR-21/SOX7 axis] CCK8//qRT-PCR//Transwell Assay The results demonstrated that NBAT1 expression decreased in glioma tissues compared to normal samples.Taken together, the results of the present study provide novel insight into the functions of NBAT1 in glioma, suggesting that the NBAT1/miR-21/SOX7 axis may act as a potential therapeutic target for the treatment of patients with glioma. Yes Overexpression of NBAT1 inhibited glioma cell proliferation, migration and invasion. 32782620 NUTM2A-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cells Regulation(trim37 ) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay Therefore, trim37 is seen as a necessary target for NUTM2A-AS1 to exert the biological function of BC. Additionally, NUTM2A-AS1 is to regulate the malignant phenotype of BC through NUTM2A-AS1/trim37 pathway. Yes We found NUTM2A-AS1 could promote the malignant phenotype of proliferation and invasion of BC. 35959349 MEG8 LncRNA Homo sapiens Myocardial Reperfusion Injury MIRI mice and OGD/R cells Interaction(miR-17-5p/CCND1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//H&E Staining//ELISA Rian was poorly expressed in MIRI mice and OGD/R cells. Furthermore, Rian bound to miR-17-5p and promoted CCND1 transcription. Notably, miR-17-5p overexpression or CCND1 silencing reversed the inhibitory effect of Rian overexpression on cardiomyocyte pyroptosis. Yes LncRNA Rian overexpression reduced cardiomyocyte pyroptosis in vivo and in vitro, as indicated by decreased NLRP3, cleaved caspase-1, GSDMD-N, IL-1β, IL-18, and TNF-α levels and increased IL-10 levels. 35264782 circPVT1 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cell lines Interaction(miR-145-5p/TBX15 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//Microarray//RNA-seq//IHC//Bioinformatics Analysis We found that circPVT1 was significantly upregulated in ccRCC tissues and positively associated with the clinical stage. We also found that circPVT1 directly binds to miRNA-145-5p via the Biotin-labelled miRNA pulldown assay and dual-luciferase reporter assay, and miR-145-5p inhibitor significantly attenuated the effect of circPVT1 knockdown on ccRCC cells. Moreover, through RNA sequencing and bioinformatics analysis, we demonstrated that TBX15 was regulated by the circPVT1/miR-145-5p axis and predicted poor prognosis in ccRCC. We found that circPVT1 was significantly upregulated in ccRCC tissues and positively associated with the clinical stage. Yes Importantly, we demonstrated that circPVT1 promoted ccRCC growth and metastasis in vitro and in vivo. 33453148 circTNPO3 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cells Interaction(IGF2BP2/SERPINH1 axis) RNA Pull-Down//qRT-PCR//FISH//RNA-seq//Microarray//IHC//IF We detected the obvious downregulation of circ-TNPO3 in ccRCC compared to matched adjacent normal tissues (n = 110). Mechanistically, we elucidated that circ-TNPO3 directly bound to IGF2BP2 protein and then destabilized SERPINH1 mRNA. Moreover, IGF2BP2/SERPINH1 axis was responsible for circ-TNPO3's function of inhibiting ccRCC metastasis. The lower circ-TNPO3 expression was found in ccRCC patients with distant metastasis, higher World Health Organization/International Society of Urologic Pathologists (WHO/ISUP) grade and more advanced tumour T stage. Yes In vitro and in vivo, circ-TNPO3 significantly suppressed the proliferation and migration of ccRCC cells. 35876041 NXTAR LncRNA Homo sapiens Prostatic Neoplasms human prostate tumors and cell lines Regulation(AR/AR-V7) In Vivo Experiment//RNA Pull-Down//qRT-PCR//ChIP In this study, we identified a long noncoding RNA (lncRNA), NXTAR (LOC105373241) that is located convergent with the AR gene and is repressed in human prostate tumors and cell lines. NXTAR bound upstream of the AR promoter and promoted EZH2 recruitment, causing significant loss of AR (and AR-V7) expression. Overall, this study uncovers a positive feedback loop, wherein NXTAR acts as a novel prostate tumor-suppressing lncRNA by inhibiting AR/AR-V7 expression, which in turn upregulates NXTAR levels, compromising enzalutamide-resistant prostate cancer. Yes Application of an oligonucleotide derived from NXTAR exon 5 (NXTAR-N5) suppressed AR/AR-V7 expression and prostate cancer cell proliferation, indicating the translational relevance of the negative regulation of AR. In addition, pharmacologic restoration of NXTAR using (R)-9b abrogated enzalutamide-resistant prostate xenograft tumor growth. 34740892 hsa_circ_0074298 CircRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues and cell lines Interaction(miR-519d /MOC2) In Vivo Experiment//Western Blot//ISH//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Hsa_circ_0074298 was highly expressed in pancreatic cancer tissues and cell lines. hsa_circ_0074298 could sponge miR-519, and miR-519d bound to SMOC2. The expression of hsa_circ_0074298 was significantly correlated with pancreatic cancer tumor size, lymph node metastasis, and pathological grade. Yes Downregulation of hsa_circ_0074298 expression significantly inhibited cell proliferation, migration, invasion, colony forming ability and promoted cell cycle arrest, apoptosis and chemo-resistance of pancreatic cancer in vitro and vivo. 34976169 NBAT1 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] CCK8//qRT-PCR//Flow Cytometry//Western Blot NBAT-1 and PTEN were lowly expressed in GC tissues compared with paracancerous tissues and normal gastric tissues. GC patients with stage Ⅲ-Ⅳ presented lower expression of NBAT-1 than those with stage Ⅰ-Ⅱ. Besides, lower expression of NBAT-1 was found in GC patients with N2-N3 compared with those with N0-N1. NBAT-1 expression was not correlated with TNM stage and distant metastasis in GC patients. Yes Upregulation of NBAT-1 in GC cells inhibited proliferation and arrested cell cycle. 31128020 NSD2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-296-3p /AKT3 ) PCR//Western Blot//Bioinformatics Analysis//IF Significantly up-regulated circWHSC1 and down-regulated microRNA-296-3p (miR-296-3p) were identified in NSCLC tissues and cells. MiR-296-3p was sponged by circWHSC1, and AKT serine/threonine kinase 3 (AKT3) was target of miR-296-3p; meanwhile, miR-296-3p over-expression significantly down-regulated AKT3 expression, and co-transfecting anti-miR-296-3p rescued circWHSC1 silence caused AKT3 down-regulation. Up-regulated circWHSC1 was associated with poor prognosis in NSCLC patients. Yes CircWHSC1 silence significantly inhibited colony formation, viability, invasion, and migration, while increased NSCLC cell apoptosis, which were partially rescued by anti-miR-296-3p. 34313353 hsa_circ_0005875 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues,cells Expression[highly expressed] qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Hsa_circ_0005875 was confirmed to be significantly upregulated in the ccRCC tumor tissues and renal carcinoma cells. Further analysis revealed that hsa_circ_0005875 expression was associated with tumor size, pathological TNM stage, histological differentiation, and lymphatic metastasis. Yes Functional experiments demonstrated that overexpression of hsa_circ_0005875 increased proliferation, migration and invasion abilities. 33193877 circAKT1 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cells regulation[up-regulating CAV1] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay In the present study, we confirmed the up-regulation of circAKT1 in ccRCC tissues and cells. To summarize, circAKT1 facilitated ccRCC progression at least partly by sequestering miR-338-3p to up-regulate CAV1 expression. High circAKT1 expression was positively associated with TNM stage, lymph node metastasis and predicted an adverse prognosis. Yes Functionally, knockdown of circAKT1 suppressed cell proliferation, colony formation, migration, invasion and EMT in vitro. 32900491 circLGMN CircRNA Homo sapiens Glioblastoma Seventy-three glioma tissues Interaction(miR-127-3p/LGMN axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//FISH//RIP//IF//Luciferase Report Assay//H&E Staining//IHC//Transwell Assay CircLGMN was upregulated in high-grade glioma (HGG), and high expression of circLGMN was associated with poor prognosis in patients with glioma. CircLGMN was upregulated in high-grade glioma (HGG), and high expression of circLGMN was associated with poor prognosis in patients with glioma. Yes CircLGMN overexpression promoted GBM cell proliferation and enhanced cell invasion. Mechanistically, circLGMN acts as a sponge for miR-127-3p, and prevents miR-127-3p-mediated degradation of LGMN mRNA, ultimately leading to increased LGMN protein expression. 34582975 MEG3-210 LncRNA Homo sapiens Endometriosis Endometrial tissues and sera regulation[p38 MAPK and PKA/SERCA2 signalling ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Transwell Assay Our results showed that MEG3-210 expression was lower in the eutopic endometrium of women with endometriosis.MEG3-210 regulates ESCs through p38 MAPK and PKA/SERCA signalling via interaction with Galectin-1. Yes MEG3-210 downregulation promoted ESCs migration, invasion, anti-apoptosis in vitro and growth of endometriotic lesions in vivo. 32446846 MYOSLID LncRNA Homo sapiens Osteosarcoma OS tissues and cell lines Regulation[MYOSLID/miR-1286/RAB13 axis] CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The expression of MYOSLID was upregulated in OS tissues and cell lines. Our work demonstrated that the MYOSLID/miR-1286/RAB13 axis is a novel regulatory signaling in promoting OS progression. Yes MYOSLID knockdown suppressed proliferation, migration and invasion of OS cells. 31849524 NT5E LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines regulation[SYNCRIP ] qRT-PCR Our results showed that lncNT5E was significantly up-regulated in PC tissues and cell lines and associated with poor prognosis. In conclusion, lncNT5E predicts poor prognosis and promotes PC progression by modulating SYNCRIP expression. Our results showed that lncNT5E was significantly up-regulated in PC tissues and cell lines and associated with poor prognosis. Yes LncNT5E depletion inhibited PC cell proliferation, migration, invasion and EMT in vitro and caused tumorigenesis arrest in vivo. 32770626 hsa_circ_0072309 CircRNA Homo sapiens Glioblastoma GBM tissues Interaction(HSP27) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Wound Healing Assay//qRT-PCR//IF//H&E Staining//IHC//EdU Staining//Transwell Assay In our work, hsa_circ_0072309 was remarkably downregulated in GBM. Moreover, we found that the function of hsa_circ_0,072,309 in GBM was associated with HSP27, which was reported to be an important regulator of cell proliferation, invasion and cytoskeletal. Yes Hsa_circ_0072309 inhibits proliferation and invasion of glioblastoma and affects cytoskeletal of GBM cells. 33862563 circDHX33 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC cell lines and tissues regulation[miR-489-3p/MEK1 axis] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Here, we present a novel circular RNA, circDHX33, that is up-regulated in ccRCC cell lines and tissues.In conclusion, our findings suggest that circDHX33 plays a role in promoting ccRCC via the miR-489-3p/MEK1 axis and may serve as a novel therapeutic target for the treatment of ccRCC patients. Upregulated circDHX33 in ccRCC patients significantly correlates with advanced TNM stage and metastasis. Yes Suppressing circDHX33 expression inhibits the proliferation and invasion of cultured cells, and suppresses tumor growth in vivo. 32717723 circAPBB1IP CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues regulation[ERK1/2 Signaling Pathway] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay The result indicated that circ-APBB1IP was significantly up-regulated in ccRCC. Further study found that knockdown of circ-APBB1IP up-regulated protein expression of cleaved caspase-3, cleaved caspase-7, cleaved caspase-8, cleaved caspase-9, Bax, Bad, Bak, E-cadherin and down-regulated expression of Bcl-2, N-cadherin, MMP-2, MMP-9, p-ERK1/2. Yes In vitro, knockdown of circ-APBB1IP by siRNA suppressed the proliferation, migration, and invasion and increased the apoptosis of ccRCC cells. 32547313 hsa_circ_0085576 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cell lines. regulation[miR-498/YAP1 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Transwell Assay In this study, using bioinformatics analysis and a series of experimental analysis, we characterized a novel circRNA, hsa_circ_0085576 was up-regulated in ccRCC tissues and cell lines. Finally, functional studies revealed that inhibition of hsa_circ_0085576 suppressed cell growth and metastasis by regulating miR-498/YAP1 signaling, in ccRCC cells. High hsa_circ_0085576 expression was significantly correlated with tumor size, clinical stage, and metastasis status and poorer survival. Yes Knockdown of hsa_circ_0085576 notably inhibited cell proliferation, migration, invasion, whereas enhanced cell apoptosis of ccRCC cells, in vitro. 32541093 NTT LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues Interaction(MYB ) qRT-PCR//Western Blot NTT was most significantly downregulated in hepatocellular carcinoma (HCC), while a higher NTT level correlated with a shorter survival time of patients with HCC. MYB was significantly upregulated, and its increased expression was associated with dismal survival in HCC patients, similar to the results for NTT. ChIP of HCC cell lines revealed that NTT is regulated by the transcription factor ATF3 and binds to the MYB promoter via the activated complex. NTT was most significantly downregulated in hepatocellular carcinoma (HCC), while a higher NTT level correlated with a shorter survival time of patients with HCC. Yes NTT knockdown significantly decreased cellular migration. 34616668 NUBE2R2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues, 95D and H1299 cells Expression(highly expressed) CCK8//qRT-PCR UBE2R2-AS1 was highly expressed in NSCLC tissues compared with that in adjacent normal tissues, which was significantly associated with lymph node metastasis and poor prognosis. UBE2R2-AS1 was highly expressed in NSCLC tissues compared with that in adjacent normal tissues, which was significantly associated with lymph node metastasis and poor prognosis. Yes Knockdown of UBE2R2-AS1 suppressed the proliferation, migration, and invasion, inhibiting the EMT process (increased E-cadherin, decreased N-cadherin and vimentin) in 95D and H1299 cells. Overexpression of UBE2R2-AS1 obtained the opposite results. 35777800 circUBAP2 CircRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues and cell lines regulation[miR-148a-3p/FOXK2 Pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Transwell Assay Our results showed that circUBAP2 expression was significantly down-regulated in ccRCC tissues and cell lines. In conclusion, these findings indicated that circUBAP2 functioned as a novel tumor suppressor in ccRCC through regulating the miR-148a-3p/FOXK2 axis. Yes Overexpression of circUBAP2 significantly inhibited the proliferation, migration, and invasion of ccRCC cells. 32425115 Metalnc9-AS LncRNA Homo sapiens Lung Neoplasms non-small cell lung cancer (NSCLC) tissues Expression(highly expressed) qRT-PCR//Invasion Assay//Migration Assay In this study, we demonstrated that the expression of Metalnc9-AS was upregulated in non-small cell lung cancer (NSCLC) tissues compared with corresponding non-tumorous tissues. Yes The gain of MetaLnc9-AS was highly associated with the malignant features of NSCLC. Overexpression of MetaLnc9-AS enhanced tumor metastasis in vitro and in vivo. 35333617 MEG8 LncRNA Homo sapiens Bone-Invasive Pituitary Adenomas BIPA tissues Interaction(miR-454-3p/TNF-α ) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA//IHC In this study, we report that lncRNA MEG8 and TNF-α are upregulated in BIPA tissues while miR-454-3p is downregulated, which is associated with poor progression-free survival (PFS).Mechanistically, MEG8 promotes TNF-α expression by sponging miR-454-3p, which ultimately leads to the occurrence of bone destruction. The mechanism is confirmed in vivo and in vitro. In this study, we report that lncRNA MEG8 and TNF-α are upregulated in BIPA tissues while miR-454-3p is downregulated, which is associated with poor progression-free survival (PFS). Yes Functional assays revealed the role of up-regulated MEG8 and down-regulated miR-454-3p in promoting bone destruction. 34016788 NBDY LncRNA Homo sapiens Pancreatic Neoplasms Interaction[KRAS ] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//IHC The bioinformatics analyses revealed LINC01420 was highly expressed in PC tissues. This study illustrated that LINC01420 accelerates PC progression through releasing miR-494-3p-silenced MYC in cytoplasm and upregulating MYC-activated KRAS in nucleus, unveiling LINC01420 as a latent therapeutic strategy for PC patients. Yes Besides, LINC01420 was pronouncedly upregulated in PC cell lines and its depletion controlled PC cell proliferation and EMT in vitro and hindered tumor growth in vivo. 31562613 circESRP1 CircRNA Homo sapiens Carcinoma, Renal Cell clear cell RCC (ccRCC) tissues and cell lines Interaction(miR-3942) Wound Healing Assay//qPCR//cell invasion assay//Colony Formation Assay//EdU Staining//Transwell Assay Lower expression of circESRP1 was found in clear cell RCC (ccRCC) tissues and cell lines. The expression level of circESRP1 exhibited a positive correlation with CTCF protein but negatively correlated with miR-3942 in 79 ccRCC tissues. Besides, circESRP1 expression level showed inversely correlated with the advanced tumor size, TNM stage and distant metastasis of ccRCC. Yes In vivo experiments, we found that overexpression of circESRP1 effectively repressed xenograft tumor growth and inhibited c-Myc-mediated EMT progression.  34775467 MYOSLID LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression(highly expressed) In Vivo Experiment//qRT-PCR The levels of MYOSLID, a hub lncRNA in our model, were higher in CRC tissues than in normal tissues. Yes Knockdown of MYOSLID induced necroptosis and inhibited the proliferation of CRC cells in vitro and in vivo. Interestingly, knockdown of MYOSLID also increased the percentage of CD4+ and CD8+ T cells in subcutaneously transplanted tumours. 36139524 MYOSLID LncRNA Homo sapiens Stomach Neoplasms gastric adenocarcinoma and paired normal tissues Interaction[MCL-1;miR-29c-3p ] qRT-PCR//RIP//Western Blot Then, the expression of lncRNA MYOSLID in GC tissues was detected by real‐time PCR and found that the expression of lncRNA MYOSLID was higher in GC tissues than in matched non‐tumour tissues (n = 75, P < .0001, Figure ​Figure1C).1C). We found for the first time that the expression of lncRNA MYOSLID was significantly Expression[Expression[up-expression]-expression]-regulated in GC tissues, and the Expression[Expression[up-expression]-expression]-regulation of lncRNA MYOSLID in GC was correlated with tumour size, AJCC stage, depth of invasion and survival time. In addition, apoptosis and growth arrest can be induced in vitro after knockExpression[down-expression] of lncRNA MYOSLID, which inhibits tumorigenesis in mouse xenografts in vivo. Further in-depth studies revealed that lncRNA MYOSLID acts as a ceRNA of miR-29c-3p, resulting in de-repression of its Expression[down-expression]stream target gene MCL-1. As shown in Table S1, high lncRNA MYOSLID expression was associated with patients age (P = .018), larger tumour size (P = .001), invasion‐related depth (P = .010) and AJCC staging (P = .001), while lncRNA MYOSLID was no significant correlation between expression and other factors including gender (P = 1.000). We also examined the association between lncRNA MYOSLID expression levels and prognosis in patients with GC. Kaplan‐Meier survival analysis showed that patients with higher lncRNA MYOSLID levels had shorter overall survival than patients with lower lncRNA MYOSLID levels (Figure ​(Figure1D).1D). In addition, lncRNA MYOSLID was significantly overexpressed in GC cell lines compared with human normal gastric epithelial cells (GES‐1) (Figure ​(Figure1E).1E). These data suggested that IncRNA MYOSLID is involved in the pathogenesis of GC. Yes In addition, apoptosis and growth arrest can be induced in vitro after knockExpression[down-expression] of lncRNA MYOSLID, which inhibits tumorigenesis in mouse xenografts in vivo. Further in-depth studies revealed that lncRNA MYOSLID acts as a ceRNA of miR-29c-3p, resulting in de-repression of its Expression[down-expression]stream target gene MCL-1. 31497917 NORAD LncRNA Homo sapiens Breast Neoplasms BC tissues Interaction(microRNA-323a-3p/PUM1/eIF2 axis) RNA Pull-Down//IHC//Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay NORAD and PUM1 were upregulated and miR-323a-3p was downregulated in BC. MiR-323a-3p inhibition reversed the role of NORAD knockdown in the biological functions of BC cells while silencing PUM1 reversed the influence of NORAD overexpression on BC cells. NORAD bound with miR-323a-3p and miR-323a-3p targeted PUM1. NORAD and miR-323a-3p functioned through the PUM1/eIF2 axis. High NORAD expression indicated a poor prognosis of BC patients. Yes NORAD inhibition or miR-323a-3p elevation inhibited malignant behaviors of BC cells. The in vivo assay revealed that NORAD inhibition or miR-323a-3p elevation inhibited tumor growth as well. 34125645 circHMGA2 CircRNA Homo sapiens Adenocarcinoma of Lung 36 paired LUAD and adjacent normal tissues. Interaction(miR-1236-3p/ZEB1 axis) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Migration Assay//qRT-PCR//FISH//Luciferase Report Assay//Microarray//IHC//Invasion Assay Through microarray analysis, we obtained the circRNA expression profile of LUAD and found that circ-HMGA2 (hsa_circ_0027446), a novel RNA, is highly expressed in LUAD. high expression of circ-HMGA2 was further verified in 36 paired LUAD and adjacent normal tissues.The luciferase reporter assay and FISH results showed that circ-HMGA2 interacts with miR-1236-3p and that miR-1236-3p interacts with ZEB1. Yes Functionally, circ-HMGA2 promoted LUAD cell metastasis in vitro and in vivo. 33762580 MEG3 LncRNA Homo sapiens Glioma glioma cells Interaction(Bcl-xL/ PI3K/Akt/NF-κB signal pathway ) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//Cell Proliferation Assay//Invasion Assay//Transwell Assay lncRNA MEG3 was lowly expressed in glioma cells as compared to noncancer cells. It is likely that MEG3 induces apoptosis in glioma cells via downregulating the Bcl-xL gene in the PI3K/Akt/NF-κB signal pathway to reduce the development of glioma. Yes Overexpression of MEG3 significantly downregulated the expression of Bcl-xL, slightly upregulated the expression of NF-κB p65 and IκBα, and reduced the proliferation of glioma cells with increased apoptosis and the migration and invasion ability. Subsequently, glioma cells overexpressing MEG3 had less tumorgenicity in xenograft mouse models. 35860793 circZNF609 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction(miR-338-3p/HRAS axis) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay CircZNF609 was elevated in NPC tissues and cell lines, and high circZNF609 expression had a poor prognosis.MiR-338-3p directly bound to circZNF609 and HRAS, and circZNF609 knockdown repressed NPC cell malignant properties by binding to miR-338-3p. MiR-338-3p was low in NPC, and miR-338-3p restoration performed anti-tumor effects in cells of NPC by targeting HRAS. CircZNF609 was elevated in NPC tissues and cell lines, and high circZNF609 expression had a poor prognosis. Yes CircZNF609 knockdown suppressed NPC progression in vitro by inhibiting cell proliferation, migration, invasion, and glycolysis and hindered tumor growth in vivo. 32970285 NONRATT009773.2 LncRNA Rattus norvegicus Bone Neoplasms BCP model rats Interaction(miR-708-5p/CXCL13 axis) qRT-PCR//FISH//Luciferase Report Assay//ELISA//Bioinformatics Analysis Our results showed that NONRATT009773.2 was significantly up-regulated in BCP model rats, whereas depletion of NONRATT009773.2 attenuated BCP.Moreover, NONRATT009773.2 functioned as a microRNA (miRNA) sponge to absorb miR-708-5p and up-regulated miRNA downstream target CXCL13, which plays fundamental roles in the initiation and maintenance of neuroinflammation and hyperalgesia. Yes Our results showed that NONRATT009773.2 was significantly up-regulated in BCP model rats, whereas depletion of NONRATT009773.2 attenuated BCP. In contrast, overexpression of NONRATT009773.2 triggered pain-like symptoms in normal animals. 35075718 MEG3 LncRNA Homo sapiens Reperfusion Injury Caco-2 cells Interaction(miR-34a-3p/SIRT1/NF-κB signaling) Western Blot//Tunel//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay//ELISA//IF Interestingly, we found that MEG3 could protect Caco-2 cells from oxygen-glucose deprivation (OGD)/reoxygenation-induced I/R injury by modulating cell proliferation and apoptosis.Mechanistically, MEG3 inhibited the expression of inflammatory factors including interleukin (IL)-1β, tumor necrosis factor (TNF)-α, interferon-gamma (IFN)-γ, inflammatory factors including interleukin (IL)-10, and transforming growth factor beta (TGFb)-1, as well as nuclear factor-kappa B (NF-κB) signaling. In response to OGD treatment in vitro, MEG3 also activated the expression of sirtuin 1 (SIRT1) by Caco-2 cells via sponging miR-34a-3p. Yes Interestingly, we found that MEG3 could protect Caco-2 cells from oxygen-glucose deprivation (OGD)/reoxygenation-induced I/R injury by modulating cell proliferation and apoptosis. Moreover, MEG3 relieved OGD-induced intestinal barrier dysfunction in vitro, as demonstrated by its significant rescue effect on transepithelial electrical resistance and the expression of tight junction proteins such as occludin and claudin-1 (CLDN1), which were impaired in OGD-treated Caco-2 cells.Furthermore, MEG3 relieved CA-induced intestinal barrier dysfunction through NF-κB signaling in vivo. 33569424 hsa_circ_0067741 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD cells and tissues Interaction(microRNA-183-5p) Western Blot//Transfection//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay//Invasion Assay//Transwell Assay We found that circ_0067741 expression was notably declined in LUAD cells and tissues.Moreover, circ_0067741 could sponge miR-183-5p to regulate LATS1 expression and then activate the Hippo/YAP pathway. Downregulation of LATS1 reversed the effects of circ_0067741 on the Hippo/YAP pathway and LUAD cells progression. Yes Overexpression of circ_0067741 inhibited the proliferation, migration, invasion, and angiogenesis of LUAD cells and promoted apoptosis. 35435136 circRANBP17 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissue and cells Interaction(miR-635/RUNX2 axis) In Vivo Experiment//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our qRT-PCR data found that circRANBP17 expression was up-regulated in NPC tissue and cells. MiR-635 was demonstrated as a direct target of circRANBP17; circRANBP17 up-regulated RUNX2 expression levels by sponging miR-635, thereby promoting NPC proliferation and invasion. Yes Functional silencing studies revealed that circRANBP17 inhibited NPC cell proliferation and invasion in vitro, and circRANBP17 down-regulation also reduced tumor growth in nude mice. 34093832 NEAT1 LncRNA Homo sapiens Parkinson Disease MPP+-treated neuroblastoma cells Interaction(miR-519a-3p/SP1 pathway) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay NEAT1 and SP1 expressions were significantly upregulated, whereas miR-519a-3p was downregulated in MPP+-treated neuroblastoma cells in a dose- and time-dependent manner when compared with control groups. Additionally, NEAT1 served as a sponge of miR-519a-3p and regulated MPP+-caused cell injury by interacting with miR-519a-3p. Also, SP1, a target gene of miR-519a-3p, rescued miR-519a-3p-mediated actions under MPP+ treatment. Importantly, NEAT1 stimulated SP1 expression through interaction with miR-519a-3p. Yes NEAT1 knockdown restrained MPP+-induced repression of cell viability and promotion of cell apoptosis and inflammation. 34508910 NEAT1 LncRNA Homo sapiens T-cell acute lymphoblastic leukemia T-ALL cells regulation[miR-146b-5p/NOTCH1 signaling pathway] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay The expression levels of NEAT1 were markedly increased, but miR-146b-5p levels were reduced in T-ALL cells. NEAT1 promotes the proliferation of T-ALL cells by sponging miR-146b-5p to upregulate the expression of NOTCH1. Yes Knockdown of NEAT1 or overexpression of miR-146b-5p decreased NOTCH1 expression, inhibited the proliferation of T-ALL cells. 33010698 MEG3 LncRNA Homo sapiens Intestinal Neoplasms clinical samples and in the Apcmin mouse model Regulation(miR-708/SOCS3/STAT3 signaling) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//H&E Staining//Cell Proliferation Assay//IHC//Bioinformatics Analysis//IF Our data showed Meg3 levels negatively correlate with miR-708 levels both in clinical samples and in the Apcmin mouse model, which indicated that Meg3 acts as a competitive endogenous RNA (ceRNA) of miR-708. Then, miR-708 served as an oncogene, inducing neoplasia in both Apcmin mice and cultured colonic organoids. Put together, miR-708 appears to promote malignant proliferation of colonic stem cells by targeting SOCS3/STAT3 signaling. Yes Then, miR-708 served as an oncogene, inducing neoplasia in both Apcmin mice and cultured colonic organoids. Put together, miR-708 appears to promote malignant proliferation of colonic stem cells by targeting SOCS3/STAT3 signaling. 34934045 MEG3 LncRNA Homo sapiens Spinal Cord Injuries ASCI mouse spinal cord tissues, primary microglia and BV2 cells Interaction(HuR/A20/NF-κB axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//RIP//ELISA//Transwell Assay//IF The lncRNA MEG3 expression was lessened in the ASCI mouse spinal cord tissues and LPS-treated primary microglia and BV2 cells, and the overexpression of lncRNA MEG3 restrained the M1 polarization of microglia and the neuroinflammation by regulating the NF-κB signaling pathway. For the investigation of the potential mechanism of such, the overexpression of lncRNA MEG3 restrained the M1 polarization of microglia through the HuR/A20/NF-κB axis and boosted the motor function recovery and neuroinflammation relief in the mice with SCI. The overexpression of lncRNA MEG3 restrained the M1 polarization of microglia through the HuR/A20/NF-κB axis. Yes For the investigation of the potential mechanism of such, the overexpression of lncRNA MEG3 restrained the M1 polarization of microglia through the HuR/A20/NF-κB axis and boosted the motor function recovery and neuroinflammation relief in the mice with SCI. The overexpression of lncRNA MEG3 restrained the M1 polarization of microglia through the HuR/A20/NF-κB axis. 35338543 NEAT1 LncRNA Homo sapiens Lung Injury patients with ARDS Interaction(miR-27a/PTEN axis) Western Blot//qPCR//CCK8//Luciferase Report Assay//Cell Cycle Assay//ELISA The expression levels of NEAT1 and pro-inflammatory cytokines were higher in patients with ARDS and septic models than in controls. Mechanistically, miR-27a was identified as a downstream target of NEAT1 and directly inhibited PTEN expression. Yes Knockdown of NEAT1 significantly increased cell proliferation and cycle progression and prolonged mouse survival in vitro and in vivo. 34239033 MEG3 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues,RCC cell lines regulation[MEG3-ST3Gal1-EGFR axis] ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Here, we found that the expression of MEG3 was higher in adjacent tissues than in RCC tissues, as well as downregulated in RCC cell lines compared to expression in normal renal cells.Taken together, our findings provide a novel mechanism to elucidate the role of the MEG3-ST3Gal1-EGFR axis in RCC progression. Yes The proliferation, migration and invasion of RCC cells transfected with MEG3 was decreased, whereas knockdown of MEG3 had the opposite effect. 32737220 NEAT1 LncRNA Homo sapiens diabetic cataract anterior capsule tissue regulation[microRNA-205-3p/MMP16 axis] qRT-PCR//Luciferase Report Assay//ChIP YY1 and NEAT1 expressions in the anterior capsule tissue of DC lens were remarkably reduced and positively correlated. The low expression of YY1 induces NEAT1 downregulation, which regulates microRNA-205-3p/MMP16 axis and thus participates in the development of DC. Yes Knockdown of NEAT1 inhibited proliferation while promoted apoptosis under high glucose conditions. 32572898 circSOX9 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Interaction(miR-485-3p/SOX9) Transwell Assay//Luciferase Report Assay//Western Blot Bioinformatics analysis showed that circSOX9 was significantly up-regulated in NPC, and its expression level was positively correlated with the malignant progression of cancer. In conclusion, circSOX9 acts as an oncogene in the progression of NPC through miR-485-3p/SOX9, indicating that circSOX9 can be used as a potential therapeutic target and predictive marker for nasopharyngeal carcinoma. Bioinformatics analysis showed that circSOX9 was significantly up-regulated in NPC, and its expression level was positively correlated with the malignant progression of cancer. Yes Data from function gain or loss studies showed that decrease of circSOX9 inhibited the invasion and proliferation of HONE1 and CNE2 cell lines. 35700516 MEG3 LncRNA Homo sapiens Pituitary Neoplasms pituitary tumor tissues and cells Interaction(miR‑23b‑3p/FOXO4 ) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay lncRNA MEG3 was expressed at lower levels in pituitary tumor tissues and cells. . lncRNA MEG3 negatively regulated miR‑23b‑3p expression levels, while miR‑23b‑3p negatively regulated FOXO4 expression levels. Overexpression of lncRNA MEG3 inhibited the EMT process in pituitary tumor cells. miR‑23‑3p inhibitor rescued the effect of shMEG3 on proliferation, invasion, migration, apoptosis and the EMT process in pituitary tumor cells. Yes Overexpression of lncRNA MEG3 inhibited proliferation, invasion and migration and accelerated apoptosis of pituitary tumor cells. 33649837 MEG3 LncRNA Homo sapiens Wilms Tumor blood regulation[Wnt/β-catenin pathway] Western Blot//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay MEG3 was lowly expressed in WT tissues and blood samples (p<0.05). Meanwhile, it could inhibit the proliferation and metastasis of WT cells via wt/β-catenin pathways. Yes Over-expression of MEG3 significantly reduced the proliferation, invasion and migration of CLS1cells than control cells (p<0.05).However, inhibition of MEG3 in WiT49 cells significantly promoted cell growth and metastasis compared with cells in negative control group (p<0.05). 33090393 circSETD3 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Interaction(circSETD3/miR-147a axis) In Vivo Experiment//IHC//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay The results showed that circSETD3 was upregulated in NPC tissues and was related to DDP resistance to NPC. In conclusion, the results of this study confirm that circSETD3 promotes NPC proliferation and DDP resistance by regulating miR-147a, and circSETD3/miR-147a axis may serve as a potential therapeutic target for NPC in the future. Yes Functional experiments revealed that circSETD3 knockdown inhibited NPC proliferation and increased DDP sensitivity and apoptosis rate. The promotion effect of circSETD3 overexpression on NPC proliferation and DDP resistance and inhibition effect on apoptosis was reversed by elevated miR-147a. 35196205 circIPO7 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC patients Interaction(YBX1/AKT/FGFR1, TNC, and NTRK1) In Vivo Experiment//RNA Pull-Down//IHC//ChIP//Western Blot//Invasion Assay//Co-IP//Migration Assay//qRT-PCR//FISH//IF//RIP//RNA-seq//ChIP-seq//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay In this study, circIPO7, a novel circRNA, is found to be specifically overexpressed in NPC patients with distant metastasis. Mechanistically, circIPO7 binds to Y-box binding protein-1 (YBX1) protein in the cytoplasm and facilitates its phosphorylation at serine 102 (p-YBX1S102) by the kinase AKT, which further promotes YBX1 nuclear translocation and activates FGFR1, TNC, and NTRK1 transcription. Clinically, higher circIPO7 expression indicates unfavorable distant metastasis-free survival in NPC patients given cisplatin-based chemotherapy. Yes Knockdown of circIPO7 in NPC cells suppresses their metastasis and increases sensitivity to cisplatin treatment in vitro and in vivo. 35917517 hsa_circ_0067934 CircRNA Homo sapiens Thyroid Neoplasms Thyroid Carcinoma tissues,cell lines Regulation[EMT and PI3K/AKT signaling pathways] CCK8//qRT-PCR//Transwell Assay//Western Blot Compared with adjacent tissue, circ_0067934 was highly expressed in thyroid tumors. Circ_0067934 expression level was highly expressed in thyroid tumor cell lines. In addition, circ_0067934 knockdown inhibited EMT and PI3K/AKT signaling pathways. Patients with high expression of circ_0067934 showed lower survival rates. Yes Knockdown of circ_0067934 inhibited cell proliferation, migration, and invasion and also promoted apoptosis. 30779728 hsa_circ_0001681 CircRNA Homo sapiens Thyroid Neoplasms TC tissues Interaction(miR-942-5p/TWIST1 signaling pathway) Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Here, we proved that hsa_circ_0001681 was increased in TC, and located majorly in the cytoplasm of TC cells. However, miR-942-5p was decreased in TC, and was negatively correlated with hsa_circ_0001681 expression.hsa_circ_0001681 acted as a miRNA sponge and completed with TWIST1 mRNA for binding to miR-942-5p, thus downregulation of hsa_circ_0001681 repressed EMT and subsequent malignant phenotype of TC cells through targeting miR-942-5p/TWIST1 signaling pathway. Yes Knockdown of hsa_circ_0001681 significantly repressed the proliferation, migration, invasion and EMT of TC cells. We also found that the process of hsa_circ_0001681 silencing limited EMT, which was obstructed by TWIST1 increasing. 34164767 NEAT1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines regulation[Inhibiting miR-146b-5p Expression] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//RIP//Transwell Assay Expression of lncRNA NEAT1 was upregulated in BC tissues and cell lines. Mechanistic investigations revealed that miR-146b-5p was a direct target of lncRNA NEAT1, and its expression was correlated negatively with expression of lncRNA NEAT1 in BC tissues. High expression of lncRNA NEAT1 predicted poor overall survival in BC patients. Yes Silencing of expression of lncRNA NEAT1 inhibited epithelial-mesenchymal transition (EMT) and suppressed the proliferation, migration and invasion of BC cells. Ectopic expression of lncRNA NEAT1 induced EMT and promoted BC progression. 32801860 MEG3 LncRNA Homo sapiens Cataract lens capsules regulation[ upregulating TP53INP1] Western Blot//Tunel//CCK8//qRT-PCR//FISH//Luciferase Report Assay We observed that MEG3 expression was up-regulated in the age-related cortical cataract (ARCC) lens capsules and positively correlated with the histological degree of ARCC.In summary, MEG3 promoted ARC progression by up-regulating TP53INP1 expression through suppressing miR-223 and promoting P53 expression, which would provide a novel insight into the pathogenesis of ARC. Yes Knockdown of MEG3 increased the viability and inhibited the apoptosis of LECs upon the oxidative stress induced by H2O2. 32841649 NEAT1 LncRNA Homo sapiens Keloid keloid tissues and fibroblasts Interaction(miR-196b-5p/FGF2 Axis) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay NEAT1 was increased and miR-196b-5p was decreased in keloid tissues and fibroblasts. NEAT1 knockdown or miR-196b-5p overexpression suppressed cell viability, migration, and extracellular matrix (ECM) component production in keloid fibroblasts. MiR-196 b-5p was a target of NEAT1, and NEAT1 overexpression reversed the effect of miR-196b-5p on keloid fibroblast progression. Moreover, we found that miR-196b-5p directly targeted FGF2. FGF2 knockdown suppressed keloid fibroblast viability, migration, and ECM protein production. FGF2 overexpression abolished the effect of miR-196b-5p overexpression on keloid fibroblast development. Yes NEAT1 knockdown or miR-196b-5p overexpression suppressed cell viability, migration, and extracellular matrix (ECM) component production in keloid fibroblasts. 33162101 circSETD3 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC cell Interaction(miR-615-5p and miR-1538/MAPRE1 ) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RNA-seq//Luciferase Report Assay//Bioinformatics Analysis//IF In vivo and in vitro experiments indicated that circSETD3 could promote NPC cell invasion and migration. It was found that circSETD3 competitively adsorbs to miR-615-5p and miR-1538 and negates their inhibitory effect on MAPRE1 mRNA, thereby upregulating the expression of MAPRE1. Yes In vivo and in vitro experiments indicated that circSETD3 could promote NPC cell invasion and migration. 33122825 circRNF13 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC clinical tissues and NPC cells Interaction(SUMO2) In Vivo Experiment//Wound Healing Assay//qRT-PCR//FISH//MTT//Cell Cycle Assay//Colony Formation Assay//Transwell Assay We found that circRNF13 was stably expressed at low levels in NPC clinical tissues and NPC cells. Moreover, circRNF13 activated the SUMO2 protein by binding to the 3'- Untranslated Region (3'-UTR) of the SUMO2 gene and prolonging the half-life of SUMO2 mRNA. Upregulation of SUMO2 promotes GLUT1 degradation through SUMOylation and ubiquitination of GLUT1, which regulates the AMPK-mTOR pathway by inhibiting glycolysis, ultimately resulting in the proliferation and metastasis of NPC. Yes In vitro and in vivo experiments showed that circRNF13 inhibited NPC proliferation and metastasis. 34465340 circGSK3B CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(GSK3B ) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay In the present research, circ-GSK3B (hsa_circ_0066903) was found to be significantly down-regulated in LUAD tissues and cells and it suppressed the proliferation, migration and stemness of LUAD cells. Furthermore, it was discovered that circ-GSK3B competitively sponged miR-3681-3p and miR-3909 to elevate GSK3B expression. Circ-GSK3B could impair the binding ability of FKBP51 to GSK-3β to inhibit the phosphorylation of GSK-3βS9, resulting in the inactivation of Wnt/β-catenin signaling. Yes In the present research, circ-GSK3B (hsa_circ_0066903) was found to be significantly down-regulated in LUAD tissues and cells and it suppressed the proliferation, migration and stemness of LUAD cells. 35821283 NEAT1 LncRNA Homo sapiens Melanoma melanoma tissues Interaction[NEAT1/miR-23a-5p/KLF3 ] CCK8//qRT-PCR//Invasion Assay//Migration Assay In this study, we observed that the expression of NEAT1 was significantly upregulated in melanoma tissues, which remarkedly promoted the cells' proliferation, cell migration, and invasion in melanoma cell lines. Our results demonstrated that NEAT1 could sponge miR-23a-3p and functions via the expression of KLF3. This axis of NEAT1/miR-23a-5p/KLF3 could together regulate melanoma cancer proliferation. Yes In this study, we observed that the expression of NEAT1 was significantly upregulated in melanoma tissues, which remarkedly promoted the cells' proliferation, cell migration, and invasion in melanoma cell lines. 31462890 Meg3 LncRNA Mus musculus Psoriasis TNF-α-treated HaCaT and NHEK cells and skin tissues of psoriatic mice model Interaction(PI3K/AKT/mTOR signalling pathway) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//MTT//ELISA//IHC//IF LncRNA MEG3 expression levels were downregulated in TNF-α-treated HaCaT and NHEK cells and skin tissues of psoriatic mice model. TNF-α-induced activation of the PI3K/AKT/mTOR signalling was abolished by lncRNA MEG3 overexpression in HaCaT and NHEK cells. Blocking the PI3K/AKT/mTOR signalling inhibited TNF-α-induced inflammation and restored autophagy level in TNF-α-treated HaCaT and NHEK cells. Yes TNF-α treatment enhanced inflammation and suppressed autophagy in HaCaT and NHEK cells, which were largely reversed by overexpression of lncRNA MEG3. Autophagy puncta and NLRP3 inflammasome assembly showed the same patterns with the expression of inflammation and autophagy markers in TNF-α-treated HaCaT and NHEK cells with or without lncRNA MEG3 overexpression. 34425525 MIAT LncRNA Homo sapiens Melanoma melanoma tissues and cell lines Interaction(miR-495-3p/HK2 axis) In Vivo Experiment//Western Blot//qPCR//RIP//Luciferase Report Assay LncRNA RNCR2 was upregulated in melanoma tissues and cell lines. Mechanically, RNCR2 was confirmed to bind to miR-495-3p and positively regulated HK2 expression level, and the miR-495-3p level was negatively correlated with RNCR2 or HK2 in melanoma tissues. Yes Cell function detection showed that RNCR2 knockdown remarkably inhibited cell proliferation and EMT via glycolysis, as well as reduced the growth of a tumor. 33724862 circSMARCC1 CircRNA Homo sapiens Prostatic Neoplasms PCa cells, plasma and tissues Interaction(miR-1322/CCL20/CCR6 signaling) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//RNA-seq//Cell Proliferation Assay//ELISA//IHC//Invasion Assay//IF CircSMARCC1 was dramatically up-regulated in PCa cells, plasma and tissues. Mechanistically, circSMARCC1 regulates the expression of CC-chemokine ligand 20 (CCL20) via sponging miR-1322 and activate PI3K-Akt signaling pathway involved in the proliferation and epithelial mesenchymal transformation. More importantly, high expression of circSMARCC1 was positively associated with colonization of CD68+/CD163+/CD206+ TAMs in tumor microenvironment. In addition, overexpression of circSMARCC1 facilitates the expression of CD163 in macrophages through the CCL20-CCR6 axis, induces TAMs infiltration and M2 polarization, thereby leading to PCa progression. Yes Overexpression of circSMARCC1 promotes tumor proliferation and metastasis both in vitro and in vivo, whereas knockdown of circSMARCC1 exerts the opposite effects. 36045408 hsa_circ_0092314 CircRNA Homo sapiens Pancreatic Neoplasms PAAD tissues and cells Interaction(miR-671) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay//Transwell Assay Circ_0092314 was markedly upregulated in PAAD tissues and cells, and its overexpression was closely correlated with worse prognosis of PAAD patients. Mechanistically, we demonstrated that circ_0092314 directly binds to miR-671 and relieve its suppression of the downstream target S100P, which induces EMT and activates the AKT signaling pathway. Circ_0092314 was markedly upregulated in PAAD tissues and cells, and its overexpression was closely correlated with worse prognosis of PAAD patients. Yes Functionally, circ_0092314 promotes proliferation, invasion and EMT in vitro and tumor growth in vivo. 33842379 hsa_circ_0081234 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(miR-1/MAP 3 K1 axis) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining The circ_0081234 level was increased in PCa tissues with spinal metastasis in comparison to primary PCa tissues without spinal metastasis. Knockdown of circ_0081234 blocked PCa cell progression by regulating miR-1. In addition, miR-1 overexpression suppressed PCa cell progression by repressing MAP 3 K1. Moreover, circ_0081234 increased MAP 3 K1 level via sponging miR-1. Yes Exosomal circ_0081234 promoted the migration, invasion and epithelial-mesenchymal transition of PCa cells. Depletion of circ_0081234 inhibited tumor growth in vivo. 34191363 NEAT1 LncRNA Homo sapiens Capsule Opacification posterior capsular tissues regulation[TGF-β/SMAD signaling pathway,NEAT1/miR-486-5p/SMAD4 axis] RNA Pull-Down//Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay NEAT1 is upregulated and miR-486-5p is downregulated in the posterior capsular tissues of PCO patients and TGF-β2-induced LECs. The activity of the TGF-β/SMAD signaling pathway is regulated by the NEAT1/miR-486-5p/SMAD4 axis. Yes Interference of NEAT1 reverses the promoting effect of TGF-β2 on the proliferation, migration, invasion and EMT of LECs. 33292220 Meg3 LncRNA Mus musculus Non-alcoholic Fatty Liver Disease liver tissues from HFD-fed mice Regulation(MEG3/EZH2/SIRT6 axis) Western Blot//qRT-PCR//RIP//Oil Red O Staining//ELISA//ChIP MEG3 level was reduced in FFA-challenged hepatocytes or liver from HFD-fed mice, and the reduction paralleled the severity of NAFLD in clinic. Overexpressing MEG3 suppressed FFA-induced lipid accumulation or inflammation in hepatocytes. By promoting the ubiquitination and degradation of EZH2, MEG3 upregulated SIRT6, an EZH2 target. SIRT6 essentially mediated the protective effects of MEG3 in hepatocytes. Consistently, overexpressing MEG3 alleviated HFD-induced NAFLD in vivo. By controlling the expressions of genes involved in lipid metabolism and inflammation, the MEG3/EZH2/SIRT6 axis significantly suppressed lipid accumulation and inflammation in vitro, and NAFLD development in vivo. Therefore, boosting MEG3 level may benefit the treatment of NAFLD. Yes Overexpressing MEG3 suppressed FFA-induced lipid accumulation or inflammation in hepatocytes. 35256601 Meg3 LncRNA Mus musculus Myocardial Infarction cell line(NMVM) Interaction[p53] qRT-PCR "The expression levels of lncRNA MEG3 in post‐MI myocardium were significantly higher than those of sham groExpression[Expression[up-expression]-expression] for the indicated time‐points.We therefore explored the association of lncRNA MEG3 with p53 in infarct hearts and hypoxic NMVMs by immunochemical, immunofluorescence and Western blotting assays. The number of p53‐positive myocardial cells in the border zone was increased following MI, which could be inhibited by lncRNA MEG3 knockExpression[down-expression] (Figure ​(Figure5A,B).5A,B). As shown in Figure ​Figure5C,D,5C,D, p53‐positive cells were markedly decreased in NMVMs that were treated with lenti‐lncRNA MEG3 compared with those treated with lenti‐GFP vectors under hypoxic conditions. Moreover, Western blotting indicated that knockExpression[down-expression] of lncRNA MEG3 decreased p53 expression compared with that noted in the control groExpression[Expression[up-expression]-expression] in infarct myocardium and hypoxic NMVMs (Figure ​(Figure5E,F).5E,F). Besides, we also found that overexpression of lncRNA MEG3 in hypoxic NMVMs could result in increase in p53 and cleaved caspase 3, indicating a promotion for myocardial apoptosis (Figure S4A‐C). " Yes Furthermore, we revealed that knockExpression[down-expression] of lncRNA MEG3 protected against endoplasmic reticulum stress (ERS)-mediated myocardial apoptosis including the induction of PERK-eIF2α and caspase 12 pathways. 31631486 Meg3 LncRNA Mus musculus Alzheimer Disease brain tissues Regulation[PI3K/Akt signaling pathway] qRT-PCR Downregulated MEG3 was detected in the tissues of AD rats. Our study highlights that upregulation of the lncRNA MEG3 improves cognitive impairment, alleviates neuronal damage, and inhibits activation of astrocytes in hippocampus tissues in AD through inhibiting the PI3K/Akt signaling pathway. Yes In addition, upregulation of MEG3 contributed to an improvement of spatial learning ability and memory ability, inhibited the pathological injury and its apoptosis of hippocampal neurons, decreased Aβ positive expression, inhibited oxidative stress injury and inflammatory injury as well as the activated astrocytes in AD rats via inactivation of the PI3/Akt pathway. 31190362 hsa_circ_0066147 CircRNA Homo sapiens Pancreatic Neoplasms PC tissues and cells Interaction(miR-326) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Invasion Assay//Migration Assay//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis circ_0066147 expression was upregulated in PC tissues and cells. Mechanistically, circ_0066147 directly targeted miR-326 and circ_0066147 modulated E2F2 expression by miR-326. Yes circ_0066147 knockdown inhibited PC cell proliferation, migration, invasion and enhanced apoptosis in vitro, as well as weakened tumor growth in vivo. 34056113 circZNF609 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues regulation[miR-188/ELF2 Axis] Western Blot//RIP//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay Circ-ZNF609 and ELF2 levels were increased and miR-188 level was decreased in NPC. Our findings demonstrated that circ-ZNF609 depletion-repressed proliferation and cell cycle transition, and induced apoptosis of NPC cells via modulation of miR-188/ELF2 axis, providing potential targets for the therapy of NPC. Yes Circ-ZNF609 knockdown significantly inhibited cell proliferation and cell cycle transition, as well as accelerated apoptosis in NPC cells. 32273713 NEAT1 LncRNA Homo sapiens Fatty Liver, Alcoholic blood regulation[LncRNA NEAT1/microRNA-129-5p/SOCS2 axis] RNA Pull-Down//Western Blot//Tunel//qRT-PCR//MTT//Luciferase Report Assay//H&E Staining MiR-129-5p was reduced while NEAT1 and SOCS2 were elevated in ASH. We have found that the inhibited NEAT1 could suppress liver fibrosis in ASH mice by promoting miR-129-5p and restraining SOCS2, thereby decelerating the development of ASH. Yes Inhibited NEAT1 or elevated miR-129-5p suppressed the elevated lipid metabolism and restrained inflammation reaction in ethanol-stimulated AML-12 cells. 33228663 circCTDP1 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines (SUNE1, SUNE2 and 6?10B cell lines) regulation[microRNA-320b/HOXA10/TGFβ2 pathway] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay In the present study, circCTDP1 expression was found to be markedly upregulated in NPC tissues and cell lines (SUNE1, SUNE2 and 6?10B cell lines).Furthermore, circCTDP1/miR‑320b promoted NPC progression by regulating the expression of homeobox A10 (HOXA10). Yes Knockdown of circCTDP1 resulted in inhibition of proliferation, migration and invasion, and promoted apoptosis of NPC cells. 31985027 circBART2.2 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and EBV-positive NPC cell lines Expression [highly expressed] ISH//qPCR//FISH//qRT-PCR//IHC In this study, EBV-encoded circBART2.2 was found to be highly expressed in NPC where it upregulated PD-L1 expression and inhibited T-cell function in vitro and in vivo. circBART2.2 promoted transcription of PD-L1 by binding the helicase domain of RIG-I and activating transcription factors IRF3 and NF-κB, resulting in tumor immune escape. Yes In this study, EBV-encoded circBART2.2 was found to be highly expressed in NPC where it upregulated PD-L1 expression and inhibited T-cell function in vitro and in vivo. 34321242 circARHGAP12 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction(EZR /TPM3 and RhoA) In Vivo Experiment//ISH//Transfection//Wound Healing Assay//qPCR//RNA-seq//Invasion Assay//IF CircARHGAP12 was significantly upregulated in NPC tissues and cell lines and promoted NPC cell migration and invasion. CircARHGAP12 was found to bind directly to the 3' UTR of EZR mRNA and promote its stability; moreover, EZR protein interacted with TPM3 and RhoA and formed a complex to promote NPC cell invasion and metastasis. Yes Overexpression or knockdown experiments revealed that circARHGAP12 regulates the expression of cytoskeletal remodeling-related proteins EZR, TPM3, and RhoA. 32931883 hsa_circ_0072088 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction( circ_0072088/miR-1261/PIK3CA) Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay First, an increase in circ_0072088 was confirmed in human LUAD tissues. Mechanistically, circ_0072088 directly downregulated miR-1261 expression, whereas increased PIK3CA gene expression was associated with poor overall survival of LUAD patients. The activation of the circ_0072088/miR-1261/PIK3CA regulatory pathway may play a significant role in the tumorigenesis and progression of LUAD. Yes Thereafter, it was mainly localized in the cytoplasm and was found to enhance cell proliferation, migration, and invasion of H1299 cells. 35474604 circNOTCH1 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction(miR-34c-5p/c-Myc axis ) RNA Pull-Down//ChIP//Western Blot//Transfection//Tube Formation Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay In the present research, our findings revealed that circ-NOTCH1 was overexpressed in NPC tissues and cells. Mechanistically, circ-NOTCH1 served as a competitive endogenous RNA to modulate c-Myc expression by sponging miR-34c-5p. Additionally, overexpression of c-Myc reversed the circ-NOTCH1 knockdown-mediated inhibition of NPC cellular progression. Yes Circ-NOTCH1 knockdown suppressed NPC cell proliferation, invasion, and migration. Subsequently, we discovered that c-Myc can activate circ-NOTCH1 by binding to the NOTCH1 promoter. 33675278 NEAT1 LncRNA Homo sapiens Aortic Aneurysm, Thoracic HAoSMC and HA-VSMC cells. Interaction(miR-324-5p/RAN) RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//EdU Staining NEAT1 was up-regulated in TAA patients, as well as HAoSMC and HA-VSMC cells. Down-regulation of NEAT1 could inhibit the proliferative abilities while promoting apoptosis of TAA cells. MiR-324-5p expression was down-regulated in both TAA tissues and cells. Then, RAN was selected out as a target of miR-324-5p. More interestingly, miR-324-5p had inhibitory effects on malignant behaviors of TAA cells. RAN was negatively related with miR-324-5p while positively correlated with NEAT1 in the tissues. Finally, the data of rescue assays manifested that RAN up-regulation could countervail the influence of down-regulation of NEAT1 on TAA cells. Yes Finally, the data of rescue assays manifested that RAN up-regulation could countervail the influence of down-regulation of NEAT1 on TAA cells. 34373133 NEAT1 LncRNA Homo sapiens Pancreatitis AR42J Cells Interaction(miR-365a-3p) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//ELISA LncRNA NEAT1 was upregulated in AR42J cells treated with 10 nmol/l caerulein, and miR-365a-3p was expressed at low levels in an AP model. In conclusion, lncRNA NEAT1 was involved in AP progression by sponging miR-365a-3p and may thus be a novel target for treating patients with AP. Yes Importantly, inhibition of lncRNA NEAT1 decreased apoptosis and inflammation in caerulein-treated AR42J cells, while these effects were reverted upon co-transfection with a miR-365a-3p inhibitor. 35325441 circPIBF1 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(Nrf2/SOD2) Western Blot//ISH//Tunel//FISH//qRT-PCR//RNA-seq//Bioinformatics Analysis Analysis of circRNA expression microarrays from the Gene Expression Omnibus database revealed that circPIBF1 was highly upregulated in lung adenocarcinoma (LUAD). CircPIBF1 could bind to nuclear factor erythroid 2-related factor 2 (Nrf2), which further promoted the expression of superoxide dismutase 2 (SOD2). In addition, Nrf2 was also observed to recruit histone acetyltransferase E1A binding protein p300 (EP300) to enhance H3K27ac modification of SOD2, thus modulating the Nrf2-Keap1 signaling pathway. CircPIBF1 was significantly overexpressed in LUAD and was related to the dismal prognosis of patients with LUAD. Yes Moreover, we found that knockdown of circPIBF1 significantly suppressed the expression of SOD2 in cells and LUAD cell growth, while enhanced the expression of pyroptosis-related factors, which were further reversed by overexpression of SOD2 or EP300. 36193777 MEG3 LncRNA Homo sapiens Arthritis, Rheumatoid cell lines Regulation[AKT/mTOR signalling pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay MEG3 was also down-regulated evidently in lipopolysaccharide (LPS)-treated chondrocyte. In summary, the protective role of MEG3 in RA was proved to be exerted by the increase in the rate of proliferation, which might correlate to the regulatory role of miR-141 and AKT/mTOR signal pathway, suggesting that MEG3 holds great promise as a therapeutic strategy for RA. Yes In-vivoexperiments also showed that cell proliferation was facilitated by MEG3 overexpression with inhibited inflammation. 31411001 circMEMO1 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD patients and cells Interaction(miR-485-3p-NEK4 ceRNA axis) In Vivo Experiment//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay Circ-MEMO1 and NEK4 were high-expressed, and miR-485-3p was low-expressed in LUAD patients and cells; moreover, circ-MEMO1 and NEK4 expression in LUAD cells could be suppressed, whereas miR-485-3p could be elevated with propofol anesthesia. Coincidently, high circ-MEMO1 was associated with low overall survival of LUAD patients, and overexpressing circ-MEMO1 could overall attenuate propofol effects in LUAD cells. Yes Functionally, propofol restrained cell viability, cell cycle entrance, cell proliferation, migration, and invasion of LUAD cells, accompanied by promoted E-cadherin and depressed CyclinD1 and Vimentin. 35521898 NORAD LncRNA Homo sapiens Osteonecrosis SONFH tissues Interaction(miR-26a-5p) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay NORAD expression was downregulated in SONFH tissues, while miR-26a-5p expression was upregulated. Moreover, NORAD improved DEX-induced inhibition of proliferation and differentiation, and promotion of apoptosis by regulation of miR-26a-5p in hBMSCs. Yes Overexpression of NORAD improved DEX-induced inhibition of proliferation and differentiation, and promotion of apoptosis in hBMSCs, while knockdown of NORAD led to the opposite results. 33413642 circSEC24A CircRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues and cell lines Interaction(miR-606) In Vivo Experiment//IHC//Western Blot//Bioinformatics Analysis//Transfection//Wound Healing Assay//Invasion Assay//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay The expression of circSEC24A in both pancreatic cancer tissues and cell lines was evidently up-regulated. Further study confirmed that circSEC24A alleviated suppression on target TGFBR2 expression by directly sponging miR-606 and then influenced the tumorigenesis of pancreatic cancer. Yes Furthermore, knockdown of circSEC24A significantly inhibited the proliferative, migration and invasive capacity of pancreatic cancer cells, whereas miR-606 inhibitor obviously counteracted these effects. 34906151 circMMD_007 CircRNA Homo sapiens Adenocarcinoma of Lung LC tissues and cells Interaction( miR-197-3p/PTPN9 axis.) Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We found that the expression of circMMD_007 was abnormally increased in LC. Knockout of circMMD_007 hindered the tumorigenesis of LC in vivo and in vitro. circMMD_007 could negatively regulate the expression of miR-197-3p. PTPN9 behaved to be a molecular target of miR-197-3p. The expression of circMMD_007 was higher in advanced stages. Yes Knockout of circMMD_007 hindered the tumorigenesis of LC in vivo and in vitro. circMMD_007 could negatively regulate the expression of miR-197-3p. PTPN9 behaved to be a molecular target of miR-197-3p. 35156900 hsa_circ_0001777 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues and cell lines Interaction(miR-942-5p/PRICKLE2 ) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ_0001777 expression was reduced in lung adenocarcinoma tissues and cell lines.Circ_0001777 could directly bind to microRNA-942-5p (miR-942-5p). The anti-tumor effects of circ_0001777 overexpression in lung adenocarcinoma cells were reversed after miR-942-5p accumulation. miR-942-5p directly bound to the 3' untranslated region (3'UTR) of prickle planar cell polarity protein 2 (PRICKLE2), and PRICKLE2 silencing reversed the anti-tumor effects of miR-942-5p knockdown in lung adenocarcinoma cells. Circ_0001777 could regulate PRICKLE2 expression by absorbing miR-942-5p. Yes Circ_0001777 overexpression restrained the proliferation, migration, invasion, and glycolysis and promoted the apoptosis of lung adenocarcinoma cells. Circ_0001777 overexpression markedly hampered tumor progression in vivo. 36103059 NORAD LncRNA Homo sapiens Psoriasis HaCaT cells Interaction(miR-26a) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//Cell Proliferation Assay In IL-22/LPS-stimulated HaCaT cells, NORAD, CDC6, and keratinocyte proliferation-related proteins (K6, K16, and K17) were up-regulated and miR-26a was down-regulated. Cell survival and proliferation were also increased. However, the results were reversed after interference with NORAD.Also, in vitro experiments revealed that NORAD negatively regulated miR-26a. Yes In IL-22/LPS-stimulated HaCaT cells, NORAD, CDC6, and keratinocyte proliferation-related proteins (K6, K16, and K17) were up-regulated and miR-26a was down-regulated. Cell survival and proliferation were also increased. However, the results were reversed after interference with NORAD. 33759666 circPVT1 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC cells and tissue specimens Interaction(β-TrCP/c-Myc/SRSF1 positive feedback loop) In Vivo Experiment//ISH//Transfection//Wound Healing Assay//FISH//qRT-PCR//IHC//Invasion Assay//Transwell Assay We find that circPVT1, a circular RNA, is significantly upregulated in NPC cells and tissue specimens. Mechanistically, circPVT1 inhibits proteasomal degradation of c-Myc by binding to β-TrCP, an E3 ubiquiting ligase. Stablization of c-Myc by circPVT1 alters the cytoskeleton remodeling and cell adhesion in NPC, which ultimately promotes the invasion and metastasis of NPC cells. Furthermore, c-Myc transcriptionally upregulates the expression of SRSF1, an RNA splicing factor, and recruits SRSF1 to enhance the biosynthesis of circPVT1 through coupling transcription with splicing, which forms a positive feedback for circPVT1 production. Yes In vitro and in vivo experiments showed that circPVT1 promotes the invasion and metastasis of NPC cells. 36199071 circP4HB CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction( miR-1184/SLC7A11 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay//IHC CircP4HB expression levels were increased in LUAD.It triggered glutathione (GSH) synthesis and, therefore protected LUAD cells from ferroptosis induced by erastin. CircP4HB may function as a competing endogenous RNA by modulating miR-1184 to regulate SLC7A11. Yes CircP4HB inhibited ferroptosis by regulating miR-1184/ SLC7A11-mediated GSH synthesis. In vivo, overexpression of circP4HB promoted tumor growth and inhibited ferroptosis. 35399564 NEAT1 LncRNA Homo sapiens Non-alcoholic Fatty Liver Disease NAFLD cellular model Interaction( miR-139-5p/c-Jun/SREBP-1c pathway) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Oil Red O Staining NEAT1, c-Jun and SREBP1c expression was markedly elevated, while miR-139-5p expression was reduced in the NAFLD cellular model. NEAT1 knockdown restrained lipid accumulation in the NAFLD cellular model by directly targeting miR-139-5p. Moreover, miR-139-5p overexpression suppressed lipid accumulation by directly suppressing c-Jun expression. In addition, c-Jun silencing suppressed lipid accumulation by directly targeting SREBP1c. Finally, miR-139-5p inhibition mitigated the inhibitory effect of sh-NEAT1 on lipid accumulation. Yes NEAT1 knockdown restrained lipid accumulation in the NAFLD cellular model by directly targeting miR-139-5p. Moreover, miR-139-5p overexpression suppressed lipid accumulation by directly suppressing c-Jun expression. In addition, c-Jun silencing suppressed lipid accumulation by directly targeting SREBP1c. Finally, miR-139-5p inhibition mitigated the inhibitory effect of sh-NEAT1 on lipid accumulation. 34808393 NORAD LncRNA Homo sapiens Cerebral Ischemia/Reperfusion Injury SH-SY5Y cells Interaction(miR-30a-5p/YWHAG) Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Luciferase Report Assay//ELISA It was demonstrated that lncRNA NORAD regulated YWHAG expression by sponging miR-30a-5p. Upregulation of lncRNA NORAD contributed to the enhancement of cell viability, the inhibition of cell apoptosis as well as the alleviation of oxidative stress and inflammation in OGD/R-injured SH-SY5Y cells, which were reversed upon elevation of miR-30a-5p. Taken together, lncRNA NORAD exerted protective effects against OGD/R-induced neural injury by sponging miR-30a-5p to upregulate YWHAG expression. Yes Decreased cell viability and temporarily increased lncRNA NORAD level were observed in SH-SY5Y cells after OGD/R. 34709972 NEAT1 LncRNA Homo sapiens Spinal Cord Injuries PC-12 cells Interaction(miR-211-5p/MAPK1 axis) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay It was found that LPS induced inflammation in the PC-12 cells, leading to significantly higher cell apoptosis rate and lower viability, and the expression level of NEAT1 was elevated by LPS. Taken together, the knockdown of NEAT1 remarkably alleviated the inflammation of SCI via miR-211-5p/MAPK1 axis. Yes However, knockdown of NEAT1 partially reversed the effects of LPS. Subsequently, the potential interaction between NEAT1 and miR-211-5p was validated and miR-211-5p inhibitor was further confirmed to antagonize the effects of NEAT knockdown. 34151707 NEAT1 LncRNA Homo sapiens Rosacea rosacea skin Interaction( miR-196a-5p/S100A9) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//ELISA NEAT1 was upregulated in rosacea skin and in LL37-treated HaCaT cells. inally, NEAT1 was able to directly interact with miR-196a-5p, and downregulating miR-196a-5p was efficient in reversing the influence of NEAT1 siRNA on S100A9. Yes Moreover, inflammatory damage was able to be reduced in vitro after knockdown of NEAT1. 33678493 hsa_circ_0129047 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD cell lines and tissues Interaction(miR-375/ACVRL1) In Vivo Experiment//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay Downregulation of hsa_circ_0129047 levels was observed in LUAD cell lines and tissues. Finally, we demonstrated that hsa_circ_0129047 sponged miR-375. This interaction facilitated the expression of the downstream target of miR-375, ACVRL1, whose upregulation inhibited the development and malignancy of LUAD.These findings demonstrate that hsa_circ_0129047 functions as a tumor inhibitor in LUAD by modulating the miR-375/ACVRL1 axis. Yes Meanwhile, the upregulation of hsa_circ_0129047 levels repressed the proliferative, migratory, and survival capacities of LUAD cells in vitro. Hsa_circ_0129047 exerted antitumor effects during in vivo tumor development. 35908770 NEAT1 LncRNA Homo sapiens Acute Kidney Injury AKI cell models Interaction(miR-22-3p/CXCL12/NF-κB ) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA NEAT1 was overexpressed and miR-22-3p was underexpressed in sepsis patients and lipopolysaccharide (LPS)-induced AKI cell models. In summary, our data showed that NEAT1 promoted LPS-induced HK2 cell injury via regulating the miR-22-3p/CXCL12/NF-κB signaling pathway, suggesting that NEAT1 knockdown might be a potential pathway for alleviating sepsis-induced AKI. Yes Knockdown of NEAT1 could promote viability and suppress apoptosis and the inflammatory response in LPS-induced HK2 cells. 35600150 NEAT1 LncRNA Homo sapiens Leukemia, Myelogenous, Chronic, BCR-ABL Positive CML cell lines and PBMCs of CML patients Interaction(miR-766-5p/CDKN1A Axis) RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay LncRNA nuclear-enriched abundant transcript 1 (NEAT1) expression levels were decreased in the CML cell lines and PBMCs of CML patients. Moreover, METTL3-mediated m6A modification induced the aberrant expression of NEAT1 in CML. Additionally, miR-766-5p was upregulated in CML PBMCs and abrogated the effects of NEAT1 on cell viability and apoptosis of the CML cells. Further, CDKN1A was proved to be the target gene of miR-766-5p and was downregulated in the CML PBMCs. Yes Overexpression of NEAT1 inhibited cell viability and promoted the apoptosis of CML cells. 34354942 NORAD LncRNA Homo sapiens Colitis, Ulcerative UC patient-derived colonic mucosal tissues, FHCs Interaction( miR-552-3p/MYD88 axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//ELISA//EdU Staining Our data exhibited higher levels of NORAD in UC patient-derived colonic mucosal tissues and TNF-α-stimulated FHCs.NORAD acted as a miR-552-3p sponge, and miR-552-3p silencing weakened NORAD inhibition-mediated effects on TNF-α-induced FHC apoptosis, inflammation, and oxidative stress. Myeloid differentiation primary response gene 88 (MYD88) was verified as a miR-552-3p target, and MYD88 overexpression whittled miR-552-3p mimic-mediated inhibition on TNF-α-induced FHC apoptosis, inflammation, and oxidative stress. Notably, TNF-α-induced NORAD regulated the nuclear factor-κappaB (NF-κB) signaling via the miR-552-3p/MYD88 axis. Yes Functional experiments presented that NORAD inhibition impaired TNF-α-induced FHC apoptosis, inflammation, and oxidative stress. 35412486 hsa_circ_0006117 CircRNA Homo sapiens Pancreatic Neoplasms PC cell lines and tissues Interaction(miR-96-5p/KRAS/MAPK Signaling Pathway) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//FISH//RNA-seq//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Subsequently, circular RNA hsa_circ_0006117 was identified as being highly expressed in PC tissues in a screen of two GEO datasets, which was further verified in PC cell lines and tissues. Moreover, we found that circular RNA hsa_circ_0006117 exerts its PC-promoting effects via activating the KRAS/mitogen-activated protein kinase (MAPK) signaling pathway. Through bioinformatics exploration and dual-luciferase reporter assays, miR-96-5p was identified as a downstream target of circular RNA hsa_circ_0006117. Yes Functional experiments subsequently indicated that circular RNA hsa_circ_0006117 facilitated the malignant behaviors of PC cells, prompting that it plays an oncogenic role in PC. 34512755 NORAD LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines Interaction[miR‑136‑5p] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay NORAD was highly expressed in NSCLC tissues and cell lines.Further investigation revealed that NORAD serves as a competing endogenous RNA for miR‑136‑5p. Yes NORAD overexpression increased NSCLC proliferation and glycolysis. 31059060 circHIPK2 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Regulation(HIPK2) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//FISH//Colony Formation Assay Herein, we established that circHIPK2 was upregulated in NPC tissues. Over-expression of circHIPK2 promoted cell proliferation in vitro and in vivo, and further studies revealed it inhibited the protein level of HIPK2 in a post-transcriptional pattern, decreasing β-catenin expression and suppressing the proliferation of NPC. Yes Over-expression of circHIPK2 promoted cell proliferation in vitro and in vivo, and further studies revealed it inhibited the protein level of HIPK2 in a post-transcriptional pattern, decreasing β-catenin expression and suppressing the proliferation of NPC. 35966290 NEAT1 LncRNA Homo sapiens lung non-small cell carcinoma NSCLC cancer stem cells Regulation(EGCG-upregulated CTR1) Flow Cytometry//Transfection//qPCR//Western Blot We observed that NEAT1 was up-regulated while copper transporter 1 (CTR1) was down-regulated in the enriched NSCLC cancer stem cells.Meanwhile, appropriate doses of EGCG restrained the stemness triggered by over-expressing NEAT1 via inducing CTR1 expression. Wnt signal pathway and epithelial-to-mesenchymal transition (EMT) process were involved in NEAT1-induced CSCs in NSCLC. Yes Knockdown of NEAT1 was able to decrease the CSC-like properties in NSCLC cells, while over-expression of NEAT1 could contribute to the stemness respectively. 29152741 circCAMSAP1 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Interaction(SERPINH1) Western Blot//Transwell Assay//Wound Healing Assay//Flow Cytometry//qRT-PCR//FISH//MTT//H&E Staining//IHC//IF We found that circCAMSAP1 was highly expressed in NPC tissues and promoted NPC proliferation and metastasis. Additionally, circCAMSAP1 promoted SERPINH1 expression through improved SERPINH1 mRNA stability by binding to the 3'-untranslated region (3'UTR) of SERPINH1. Highly expressed SERPINH1 reduced the ubiquitination-degradation rate of c-Myc, causing increased tumorigenesis. Meanwhile, c-Myc, cooperating with splicing factor 10 (SRSF10), could also promote CAMSAP1 pre-mRNA transcription and back-splicing, forming a positive feedback of circCAMSAP1 production, resulting in the proliferation and metastasis of NPC. Yes We found that circCAMSAP1 was highly expressed in NPC tissues and promoted NPC proliferation and metastasis. 35227262 Norad LncRNA Mus musculus Atherosclerosis atherosclerotic mouse aortas. Interaction(microRNA-495-3p/KLF5) RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA//IHC NORAD and KLF5 were increased whereas miR-495-3p was decreased in atherosclerotic mouse aortas.Effects of elevated miR-495-3p on atherosclerotic mice could be reversed by up-regulation of KLF5. NORAD served as a sponge of miR-495-3p and miR-495-3p directly targeted KLF5. Yes Inhibited NORAD or elevated miR-495-3p suppressed inflammation, oxidative stress, endothelial dysfunction, blood lipid level, atherosclerotic plaque area, collagen fibers and CD68 expression in atherosclerotic mouse aortas. 33636159 Norad LncRNA Mus musculus Atherosclerosis ox-LDL-treated HUVECs and thoracic aorta of atherosclerotic mice Interaction(VEGF/HDAC6/H3K9 deacetylation) Western Blot//Co-IP//qRT-PCR//Luciferase Report Assay//ELISA//ChIP The present study found that lncRNA NORAD expression was increased in ox-LDL-treated HUVECs and thoracic aorta of atherosclerotic mice, and knockdown of lncRNA NORAD alleviated vascular endothelial cell injury and atherosclerosis development in vitro and in vivo. In summary, lncRNA NORAD enhanced vascular endothelial cell injury and atherosclerosis through suppressing VEGF gene transcription via enhancing H3K9 deacetylation by recruiting HDAC6. Yes The present study found that lncRNA NORAD expression was increased in ox-LDL-treated HUVECs and thoracic aorta of atherosclerotic mice, and knockdown of lncRNA NORAD alleviated vascular endothelial cell injury and atherosclerosis development in vitro and in vivo.Knockdown of lncRNA NORAD aggravated ox-LDL-reduced or atherosclerosis-decreased vascular endothelial growth factor (VEGF) expression in HUVECs and thoracic aorta of mice to ameliorate vascular endothelial cell injury and atherosclerosis development. 34307380 MEG3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Regulation[MEG3-miR-4261-DKK2-Wnt/β-catenin signalling axis] Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay Here, we found that MEG3 expression was significantly downregulated in tumour tissues.Our study for the first time elaborated the critical role of MEG3-miR-4261-DKK2-Wnt/β-catenin signalling axis in ESCC, and MEG3 could represent a novel diagnostic and prognostic biomarker and therapeutic target in ESCC. Here, we found that MEG3 expression was significantly downregulated in tumour tissues, and its low expression was associated with large tumour size, lymph node metastasis and advanced clinical stage in ESCC patients. Univariate and multivariate analyses revealed low expression of MEG3 as an independent predictor for disease-free survival and overall survival. Yes Cell experiments showed that MEG3 inhibited ESCC cell proliferation, migration and invasion. 30990378 circFBXW7 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[NEK2, mTOR, and PTEN signaling pathways] CCK8//Wound Healing Assay//PCR//Transwell Assay CRC samples had a significantly lower level of circ-FBXW7 compared to normal tissue. Further study found that si circ-FBXW7 up-regulated the mRNA and protein expressions of NEK2 and mTOR, and diminished the PTEN expression. Whereas, overexpressed circ-FBXW7 induced the tumor suppression via reversing the expressions of NEK2, mTOR, and PTEN. Yes si circ-FBXW7 notably promoted the proliferation, colony formation, cell migration and invasion of CRC cell in vitro. On contrast, circ-FBXW7 overexpressed significantly suppressed CRC cell proliferation, migration and invasion. Similarly, si circ-FBXW7 stimulated the tumor growth and circ-FBXW7 overexpression repressed the tumor progression in SW480 and SW620 tumor models, which suggested that circ-FBXW7 could serve as a target biomarker of CRC. 31519156 circCSPP1 CircRNA Homo sapiens Colorectal Neoplasms colorectal carcinoma tissues regulation[circCSPP1/miR-193a-5p/COL1A1 axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down By bioinformatic analysis of 10 paired samples of colorectal carcinoma and adjacent mucosal tissues, we identified circCSPP1 as a significantly upregulated circRNA in colorectal carcinoma tissues, and its upregulation was correlated with a higher M stage. In conclusion, this finding indicates that circCSPP1 may act as a promising therapeutic target by regulating the EMT process in colorectal carcinoma via activation of the circCSPP1/miR-193a-5p/COL1A1 axis. Yes The gain- and loss-of-function assays revealed that circCSPP1 promotes the migration and invasion of colorectal carcinoma cells in vitro and in vivo. 32612946 MEG3 LncRNA Homo sapiens Diabetic Retinopathy Blood regulation[miR-93/Nrf2 Axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay lncRNA MEG3 and Nrf2 were decreased and miR-93 was increased in blood samples of DR patients and HG-treated human RPE and ARPE-19 cells. Yes Overexpression of miR-93 inhibited cell proliferation and promoted apoptosis, whereas overexpression of Nrf2 or MEG3 promoted proliferation and suppressed apoptosis and inflammation. 32473920 NEAT1 LncRNA Homo sapiens Stomach Neoplasms H. pylori-infected gastric cancer tissues Interaction(miR-30a/COX-2/BCL9 pathway) Western Blot//Transfection//Migration Assay//qRT-PCR//FISH//Luciferase Report Assay//IHC//Invasion Assay FISH and RT-qPCR demonstrated that the expression of NEAT1 was up-regulated in gastric cancer tissues, especially in H. pylori-infected gastric cancer tissues, and the expression of NEAT1 was negatively correlated with miR-30a (miR-30a-3p and miR-30a-5p). The dual-luciferase reporter assay identified that NEAT1 directly targeted miR-30a (miR-30a-3p and miR-30a-5p). Because miR-30a (miR-30a-3p and miR-30a-5p) negatively regulates the expression of downstream COX-2 and BCL9, NEAT1 was identified to upregulate indirectly the expression of COX-2 and BCL9. Yes The upregulation of NEAT1 enhanced proliferation, migration, and invasion of H. pylori filtrate-infected gastric cancer cells, while the downregulation of NEAT1 decreased these abilities, and miR-30a could reverse the effect of NEAT1 on these abilities. 34396632 NEAT1 LncRNA Homo sapiens Acute Kidney Injury TECs Interaction(miR-129-5p) In Vivo Experiment//Northern Blot//Western Blot//ISH//qPCR//Tunel//RIP//Luciferase Report Assay//RNA-seq//Cell Apoptosis Assay//IHC//ChIP By high-throughput RNA sequencing, we found that Neat1_2, a transcript variant of Neat1, was upregulated in 40-min ischemia/reperfusion injury (IRI), which resulted in the development of renal fibrotic lesions. The upregulation of Neat1_2 in hypoxia-treated TECs was attributed to p53 transcriptional regulation.Mechanistically, Neat1_2 shares miRNA response elements with FADD, CASP-8, and CASP-3. Neat1_2 competitively binds to miR-129-5p and prevents miR-129-5p from decreasing the levels of FADD, CASP-8, and CASP-3, and ultimately facilitates TEC apoptosis. Increased expression of Neat1_2 associated with kidney injury and TEC apoptosis was recapitulated in human AKI, highlighting its clinical relevance. Yes Gain- and loss-of-function studies, both in vitro and in vivo, demonstrated that Neat1_2 promoted apoptosis of injured TECs induced by IRI and caused tubulointerstitial inflammation and fibrosis. 35619557 hsa_circ_0006401 CircRNA Homo sapiens Colorectal Neoplasms metastatic CRC tissue samples Expression [highly expressed] In Vivo Experiment//Western Blot//Co-IP//Flow Cytometry//qRT-PCR//H&E Staining//IHC In our study, we found hsa_circ_0006401 was closely related to CRC metastasis and exhibited upregulated expression in metastatic CRC tissue samples. Yes Proliferation and migration were inhibited in vitro when hsa_circ_0006401 expression was silenced. Downregulation of hsa_circ_0006401 expression decreased CRC proliferation and liver metastasis in vivo. 33947841 MEG3 LncRNA Homo sapiens Meningioma MEN tissues and cell line regulation[miR-29c/AKAP12 axis] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//CCK8//Transwell Assay Levels of MEG3 and AKAP12 were downregulated, while miR-29c was effectively increased in MEN tissues and cell line. Also, AKAP12 was co-regulated by MEG3/miR-29c axis. MEG3 mediated the aggressive behaviors of MEN cells via miR-29c/AKAP12 axis, supporting that MEG3 served as a promising biomarker for the diagnosis and treatment of human MEN. Yes Functionally, increase of MEG3 diminished cell-cycle, migration, invasion, and proliferation in MEN cells, and reintroduction of miR-29c could eliminate these effects. 33251130 circFOXM1 CircRNA Homo sapiens Nasopharyngeal carcinoma nasopharyngeal carcinoma tissue and cells Interaction(miR-136-5p-SMAD2 axis) Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay In this study, we found that circFOXM1 is highly expressed in nasopharyngeal carcinoma tissue cells compared with adjacent normal tissues and is related to the staging of nasopharyngeal carcinoma. CircFOXM1 promotes the malignant proliferation of nasopharyngeal carcinoma cells by regulating the miR-136-5p-SMAD2 axis. High expression of circFOXM1 indicates a poor prognosis for nasopharyngeal carcinoma. Yes Knockdown of CircFOXM1 inhibited the proliferation and invasion of nasopharyngeal carcinoma cells. 35266323 hsa_circ_0071036 CircRNA Homo sapiens Pancreatic Neoplasms PDAC cell lines and tissue samples Interaction(miR-489) qRT-PCR//Cell Proliferation Assay//Cell Apoptosis Assay//Microarray//cell invasion assay//Luciferase Report Assay//Colony Formation Assay Hsa_circ_0071036 was remarkably overexpressed in PDAC cell lines and tissue samples, which negatively correlated with miR-489 expression. Mechanistic analyses indicated that hsa_circ_0071036 acted as an efficient miRNA sponge for miR-489 in PDAC. Aberrant expression of hsa_circ_0071036 correlated with poor clinicopathological characteristics and prognoses of PDAC patients. Yes Knockdown of hsa_circ_0071036 suppressed proliferation and invasion and induced apoptosis in vitro. Moreover, the in vivo xenograft model confirmed that silencing of hsa_circ_0071036 attenuated tumor growth. 33507122 circPLCE1 CircRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(HSP90α/RPS3 complex) In Vivo Experiment//RNA-seq A novel protein circPLCE1-411 encoded by circular RNA circPLCE1 was identified as a crucial player in the NF-κB activation of CRC. Mechanistically, circPLCE1-411 promoted the ubiquitin-dependent degradation of the critical NF-κB regulator RPS3 via directly binding the HSP90α/RPS3 complex to facilitate the dissociation of RPS3 from the complex, thereby reducing NF-κB nuclear translocation in CRC cells. Clinically, circPLCE1 was downregulated in CRC tissues and correlated with advanced clinical stages and poor survival. Yes Functionally, circPLCE1 inhibited tumor proliferation and metastasis in CRC cells, as well as patient-derived xenograft and orthotopic xenograft tumor models. 34412652 MEG3 LncRNA Homo sapiens Mouth Neoplasms tissues of oral cancer Interaction(miR-421) qRT-PCR//Invasion Assay//Transwell Assay MEG3 was downregulated in the tissues of oral cancer and associated with a poor prognosis. Luciferase reporter assay showed that miR-421 directly interacted with MEG3, and our subsequent experiment demonstrated that elevation of miR-421 reversed the MEG3-inhibited characteristics of oral CSCs. Yes In oral CSCs, the expression of MEG3 was repressed and overexpression of MEG3 resulted in suppression of self-renewal and invasion abilities. 33012637 hsa_circ_0005100 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-145-5p/MACC1 axis) Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay Hsa_circ_0005100 and MACC1 expression levels were increased, but miR-145-5p expression level was diminished in CRC. Furthermore, miR-145-5p was disclosed to block CRC via overturning MACC1. Hsa_circ_0005100 targeted miR-145-5p to modulate MACC1. Yes Hsa_circ_0005100 knockdown repressed cell proliferation, cell cycle, migration, and invasion, while expedited cell apoptosis in CRC cells. Additionally, hsa_circ_0005100 knockdown also attenuated tumorigenesis in vivo. 35766445 NEAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues and cells Interaction(microRNA-204-5p/SEMA4B axis) Western Blot//ISH//Bioinformatics Analysis//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay The RT-qPCR results showed that NEAT1 was highly expressed and miR-204-5p had decreased expression in LSCC tissues and cells compared with that in the normal tissue and the 16HBE-14o cell line, respectively. Besides, further experiments revealed that miR-204-5p was a target of NEAT1. At the same time, silenced miR-204-5p reversed the anti-tumor effects of si-NEAT1. In addition, SEMA4B was targeted by miR-204-5p in LSCC cells and upregulated SEMA4B weakened the antitumor effects of miR-204-5p in LSCC cells. Yes Knockdown of NEAT1 using small interfering (si) RNA and overexpressed miR-204-5p both effectively inhibited the proliferation, migration and invasion of LSCC cells. Besides, further experiments revealed that miR-204-5p was a target of NEAT1. At the same time, silenced miR-204-5p reversed the anti-tumor effects of si-NEAT1. In addition, SEMA4B was targeted by miR-204-5p in LSCC cells and upregulated SEMA4B weakened the antitumor effects of miR-204-5p in LSCC cells. 34630709 hsa_circ_0007331 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(circ_0007331/miR-205-5p/HMGA2 axis ) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay circ_0007331 is expressed more frequently in patients with CRC. This study demonstrated that the circ_0007331/miR-205-5p/HMGA2 axis promotes CRC development. Thus, circ_0007331 may be a potential biomarker for CRC. Yes The inhibition of circ_0007331 expression reduced the viability, colony formation, migration, and invasion of CRC cells. However, inhibition of miR-205-5p or elevation of high-mobility group A2 (HMGA2) can reverse the function of inhibited circ_0007331 in tumor cells. 35400282 circRIP2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(CBFB) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining CircRIP2 was upregulated in these samples of CRC tissues and cell lines. CBFB was downregulated in CRC tissues, which was negatively regulated by circRIP2 as its target gene. The attenuated proliferative and migratory abilities in Sw620 and HCT-116 cells with circRIP2 knockdown were abolished by co-silence of circRIP2 and CBFB. High level of circRIP2 predicted advanced staging, and high risk of distant metastasis of CRC. Yes In vitro knockdown of circRIP2 weakened proliferative and migratory abilities in Sw620 and HCT-116 cells. Moreover, in vivo knockdown of circRIP2 slowed down CRC growth in nude mice, and upregulated positive expression of CBFB in xenografted CRC tissues. 35647832 circCCNB1 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC biopsies and cell lines. Interaction(NF90/TJP1) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay We found that the circular RNA circCCNB1, encoded by the oncogene CCNB1, was downregulated in NPC biopsies and cell lines. Moreover, circCCNB1 induces a protein, nuclear factor 90 (NF90), to bind and prolong the half-life of tight junction protein 1 (TJP1) mRNA. Upregulation of TJP1 enhances tight junctions between cancer cells and inhibits NPC cell migration and invasion. Yes In vitro assays show that circCCNB1 inhibits NPC cell migration and invasion. 35471687 NEAT1 LncRNA Homo sapiens Liver Failure, Acute clinical samples and D-GalN/LPS induced ALF mouse model Interaction(EZH2/ microRNA-139/PUMA axis) In Vivo Experiment//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//ELISA//ChIP Expression of lncRNA NEAT1, enhancer of zeste homolog 2 (EZH2), and PUMA was upregulated, while the expression of miR-139 was downregulated in clinical samples and D-GalN/LPS induced ALF mouse model. LncRNA NEAT1 promoted the enrichment of H3K27me3 on the promoter region of miR-139 via EZH2, which led to suppression of miR-139. The inhibition of miR-139 resulted in the upregulation of its downstream target PUMA. Yes The NEAT1/miR-139/PUMA pathway upregulated the production of pro-inflammatory cytokines, tumor necrosis factor alpha, interleukin (IL)-6, and IL-1β, thereby mediating the progression of ALF. 33901015 Meg3 LncRNA Rattus norvegicus Colitis, Ulcerative Caco-2 damage models and UC rats Interaction(miR-98-5p/IL-10) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC LncRNA MEG3 and IL-10 levels were distinctly decreased while miR-98-5p was increased in Caco-2 damage models and UC rats.Bioinformatics analysis predicted the binding sites of lncRNA MEG3 to miR-98-5p and miR-98-5p to IL-10. Yes Overexpressed lncRNA MEG3 reduced. DAI scores and colon weight/length ratio improved UC ulceration. In addition, upregulation of lncRNA MEG3 relieved oxidative stress, inflammatory response, apoptosis, and pyroptosis of UC rat colons. LncRNA MEG3 overexpression alleviates the serve ulceration of UC rat colons by upregulating IL-10 expression via sponging miR-98-5p. 33394187 circFOXM1 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(miR-515-5p/ADAM10 axis) RNA Pull-Down//qRT-PCR//Cell Cycle Assay//Colony Formation Assay//Transwell Assay As a result, we found that circFOXM1 and ADAM10 expression were upregulated in PCa tissues and cells. Additionally, circFOXM1 directly sponged miR-515-5p, and miR-515-5p bound to ADAM10. ADAM10 absence also repressed PCa process. Furthermore, in-vivo tumor formation assay revealed that both circFOXM1 silencing and ADAM10 knockdown repressed tumor growth in vivo. Thus, we came a conclusion that circFOXM1 contributed to PCa progression via regulating miR-515-5p/ADAM10 axis. Yes Functional analysis showed that circFOXM1 silencing repressed proliferation, migration and invasion, and induced cell cycle arrest, whereas these effects were partly reversed by miR-515-5p inhibitor. 34387599 hsa_circ_0005962 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines Interaction(miR-3611/ CYP24A1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay Increased circ_0005962 and CYP24A1, and reduced miR-3611 were observed in LUAD tissues and cell lines. Molecular mechanism experiments exhibited that circ_0005962 served as a miR-3611 sponge and mediated CYP24A1 content by absorbing miR-3611. Additionally, silencing of circ_0005962 inhibited tumor growth in xenograft modes. Yes Functional assays testified that circ_0005962 depletion might hinder LUAD cell proliferation and sphere formation capability, but induced cell apoptosis in vitro. 36542209 hsa_circ_0020850 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues and cells Interaction(miR-326/BECN1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Tube Formation Assay//Migration Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay We found that circ_0020850 was obviously overexpressed in lung adenocarcinoma tissues and cells.MiR-326 was a target of circ_0020850, and knockdown of miR-326 abolished the suppression effect of circ_0020850 on the malignant behaviors of lung adenocarcinoma cells. Additionally, miR-326 could negatively regulate BECN1 expression, thereby regulating lung adenocarcinoma cell phenotypes. Importantly, circ_0020850 could directly bind to miR-326 and thus relieve miR-326-mediated inhibition on BECN1. Yes Knockdown of circ_0020850 inhibited migration, invasion, proliferation, and angiogenesis but induced apoptosis in lung adenocarcinoma cells in vitro, as well as curbed tumor growth in vivo. 35012553 hsa_circ_0008450 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues,cell lines Interaction[targeting miR-577] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results showed that circ_0008450 was elevated in NPC tissues and cells. Mechanistically, circ_0008450 reduced miR-577-mediated repression of CXCL9, resulting in facilitating the oncogenic functions of NPC. Yes Silenced circ_0008450 could inhibit cell proliferation, and metastatic properties and increased the number of apoptotic cells. Ectopically expressed circ_0008450 strengthened the abovementioned malignant biological behaviors. 31344361 circRPPH1 CircRNA Homo sapiens Glioblastoma glioblastoma cells Expression(highly expressed) CCK8//qRT-PCR//Wound Healing Assay//Colony Formation Assay The expression of circ_0000512 was upregulated in glioblastoma cells, and the overexpression of circ_0000512 was beneficial to the proliferation, migration, invasion, and epithelial-mesenchymal transition of U87 cells, while knockdown of circ_0000512 showed the opposite results. Yes The expression of circ_0000512 was upregulated in glioblastoma cells, and the overexpression of circ_0000512 was beneficial to the proliferation, migration, invasion, and epithelial-mesenchymal transition of U87 cells, while knockdown of circ_0000512 showed the opposite results. 35928926 MCM3AP LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(microRNA-195-5p/E2F3) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay We demonstrated that MCM3AP-AS1 was overexpressed in NSCLC tissues and cells, and MCM3AP-AS1 overexpression accelerated the proliferation, migration and invasion of NSCLC cells. In addition, MCM3AP-AS1 overexpression markedly up-modulated Bcl-2 expression and repressed Bax expression; MCM3AP-AS1 overexpression also significantly up-regulated N-cadherin expression and suppressed E-cadherin expression in NSCLC cells. What is more, in NSCLC cells, miR-195-5p was a target of MCM3AP-AS1, and the latter worked as a molecular sponge for miR-195-5p to regulate E2F3 expression. Yes We demonstrated that MCM3AP-AS1 was overexpressed in NSCLC tissues and cells, and MCM3AP-AS1 overexpression accelerated the proliferation, migration and invasion of NSCLC cells. 34346845 hsa_circ_0030586 CircRNA Homo sapiens Prostatic Neoplasms PCa cells Regulation( PI3K-AKT signaling) In Vivo Experiment//Invasion Assay//Migration Assay//CCK8//qRT-PCR//RNA-seq//Bioinformatics Analysis Our results showed that hsa_circ_0030586 is significantly upregulated in PCa cells (p < 0.05). Interfering with hsa_circ_0030586 in PC3 cells inhibited cell proliferation, migration, and invasion and led to the significant upregulation of E-cadherin and the significant downregulation of p-AKT/AKT, IKKα, PIK3CB, and Twist (all p < 0.05). Interfering with hsa_circ_0030586 in PC3 cells inhibited cell proliferation, migration, and invasion and led to the significant upregulation of E-cadherin and the significant downregulation of p-AKT/AKT, IKKα, PIK3CB, and Twist (all p < 0.05). Yes Interfering with hsa_circ_0030586 in PC3 cells inhibited cell proliferation, migration, and invasion and led to the significant upregulation of E-cadherin and the significant downregulation of p-AKT/AKT, IKKα, PIK3CB, and Twist (all p < 0.05). 34852706 circPOLA2 CircRNA Homo sapiens Glioblastoma GBM tissues Regulation(PTEN) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Cell Apoptosis Assay Our data revealed that circ_POLA2 was upregulated and PTEN was downregulated in GBM. PTEN showed an inverse correlation to circ_POLA2 across GBM tissues, In GBM cells, circ_POLA2 overexpression decreased PTEN accumulation, but PTEN overexpression failed to significantly affect circ_POLA2 expression. Yes Moreover, PTEN reduced the inhibitory effects of circ_POLA2 on GBM cell apoptosis. Circ_POLA2 is overexpressed in MCL and might promote GBM cell apoptosis through downregulating PTEN. 36730613 circSMARCA5 CircRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Interaction(miR-181b-5p/miR-17-3p-TIMP3 axis) In Vivo Experiment//Western Blot//qRT-PCR//RIP//Luciferase Report Assay In primary and metastatic prostate cancer tissues, circSMARCA5 was significantly downregulated compared with normal controls. At the molecular level, circSMARCA5 could affect the tissue inhibitor of metalloproteinases 3 (TIMP3) expression through miR-181b-5p or miR-17-3p interactions. Moreover, lysine acetyltransferase 5 (KAT5) induced circSMARCA5 biogenesis and regulated the miR-181b-5p-TIMP3 and miR-17-3p-TIMP3 axis. Yes Functionally, circSMARCA5 exhibited a suppressive effect on prostate cancer cells' metastasis and growth. 34390329 circPDE5A CircRNA Homo sapiens Prostatic Neoplasms PCa tissues Regulation(WTAP-EIF3C-MAPK signaling pathway ) In Vivo Experiment//Western Blot//FISH//qRT-PCR//Luciferase Report Assay//IF circPDE5A was identified downregulated in PCa tissues compared to adjacent normal tissue and was negatively correlated with gleason score of PCa patients. circPDE5A blocks the WTAP-dependent N6-methyladenisine (m6A) methylation of eukaryotic translation initiation factor 3c (EIF3C) mRNA by forming the circPDE5A-WTAP complex, and finally disrupts the translation of EIF3C. Moreover, the circPDE5A-dependent decrease in EIF3C expression inactivates the MAPK pathway and then restrains PCa progression. circPDE5A was identified downregulated in PCa tissues compared to adjacent normal tissue and was negatively correlated with gleason score of PCa patients. Yes circPDE5A inhibits PCa cells migration and invasion both in vitro and in vivo. 35650605 MCM3AP-AS1 LncRNA Homo sapiens Hemangioma IH patients Interaction( miR-138-5p/HIF-1α Axis-Regulated Glycolysis) ISH//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC We first documented that the expression of LncRNA MCM3AP-AS1 was significantly upregulated in IH. Furthermore, we demonstrated that MCM3AP-AS1 bound to miR-106b-3p which promotes glycolysis in IH.Taken together, we demonstrate that LncRNA-MCM3AP-AS1 promotes the progression of infantile hemangiomas by increasing the glycolysis via regulating miR-138-5p/HIF-1α axis. Yes In addition, we found that inhibition of HIF-1α contributed to the transformation of glycolysis to normal aerobic oxidation, partially reversed the promoting effect on glycolysis by the up-regulation of LncRNA MCM3AP-AS1 in IH disease. More importantly, we demonstrated this phenomenon existed in IH patients. 34660700 circMID1 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction( miR-330-3p/YTHDC2/IGF1R/AKT axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Our results showed that circMID1 was upregulated in PCa tissues and cells and its knockdown inhibited PCa cell proliferation, migration, invasion and glycolysis in vitro, as well as PCa tumorigenesis in vivo. In conclusion, our data confirmed that circMID1 might play a pro-cancer role in PCa, which promoted PCa progression through regulating the miR-330-3p/YTHDC2/IGF1R/AKT axis. Yes Our results showed that circMID1 was upregulated in PCa tissues and cells and its knockdown inhibited PCa cell proliferation, migration, invasion and glycolysis in vitro, as well as PCa tumorigenesis in vivo. 35212614 MCM3AP-AS1 LncRNA Homo sapiens cervical squamous cell carcinoma Interaction(miR-21/PTEN Axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay We found that MC-M3AP-AS1 was downregulated in CSCC patients, and its low level was closely correlated with patients' poor survival. MCM3AP-AS1 could directly interact with miR-21. However, miR-21 overexpression failed to affect MCM3AP-AS1 expression. Interestingly, MCM3AP-AS1 overexpression decreased the expression of PTEN, which is a target of miR-21. Therefore, MCM3AP-AS1 may regulate the miR-21/PTEN axis to regulate CSCC cell proliferation and apoptosis. We found that MC-M3AP-AS1 was downregulated in CSCC patients, and its low level was closely correlated with patients' poor survival. Yes Cell proliferation and apoptosis analysis showed that MCM3AP-AS1 and PTEN overexpression increased apoptosis but decreased proliferation of CSCC cells. MiR-21 overexpression played an opposite role and attenuated the effects of MCM3AP-AS1 overexpression. 35695665 NONRATG019935.2 LncRNA Rattus norvegicus Acute Kidney Injury AKI rats and LPS-treated NRK-52E cells Regulation(p53) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//RIP//RNA-seq//Cell Apoptosis Assay//H&E Staining//Luciferase Report Assay//IHC Among the four DE-Lncs, the expression level of lncRNA NONRATG019935.2 (9935) exhibited the most significant reduction in both septic AKI rats and LPS-treated NRK-52E cells (a rat RTEC line). Mechanistically, 9935 decreased the human antigen R (HuR)-mediated Tp53 mRNA stability by limiting the combination of HuR and the 3'UTR region of Tp53 mRNA in RTECs. Yes The overexpression of 9935 suppressed cell apoptosis and p53 protein level in LPS-treated NRK-52E cells, and retarded septic AKI development in the rat model of septic AKI. 34719669 hsa_circ_0094606 CircRNA Homo sapiens Prostatic Neoplasms PCa cells Interaction(PRMT1/ILF3/IL-8 regulation pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//FISH//Colony Formation Assay//Transwell Assay Mass spectrometry analysis after RNA pull-down experiment identified that circ_0094606 bound to PRMT1 in PCa cells, and further functional assays revealed that circ_0094606 promoted malignant progression of PCa by binding to PRMT1. Moreover, Co-IP, GST pull-down and Immunofluorescence showed that PRMT1 mediated arginine methylation of ILF3 to stabilize the protein. Bioinformatics analysis combined with data from RIP and RNA-pull down suggested that ILF3 could stabilize IL-8 mRNA, which promoted the M2 polarization in co-culture study. Yes In the present study, we found that hsa_circ_0094606 (subsequently named circ_0094606) could promote proliferation, epithelial mesenchymal transition (EMT) as well as migration of PCa cells through cell viability and migration assays and the determination of EMT markers. 36394342 MCM3AP-AS1 LncRNA Homo sapiens cervical squamous cell carcinoma regulation[miRNA-93] CCK8//qRT-PCR The results showed that MCM3AP-AS1 was down-regulated in CSCC and predicted poor survival. Therefore, MCM3AP-AS1 may inhibit cell proliferation in CSCC by down-regulating miRNA-93. The results showed that MCM3AP-AS1 was down-regulated in CSCC and predicted poor survival. Yes Cell proliferation analysis showed that overexpression of MCM3AP-AS1 led to reduced proliferation rate of CSCC cells. Silencing of MCM3AP-AS1 played an opposite role and overexpression of miR-93 reduced the effects of overexpressing MCM3AP-AS1. 31985002 MCM3AP-AS1 LncRNA Homo sapiens Small Cell Lung Carcinoma patients with SCLC Interaction(miR-148a/ROCK1 ) RNA Pull-Down//Western Blot//Transfection//qPCR//Luciferase Report Assay//cell invasion assay MCM3AP-AS1 was upregulated in patients with SCLC, and a high MCM3AP-AS1 level was accompanied by a low survival rate. MCM3AP-AS1 sponges miR-148a, thereby increasing SCLC cell invasion and migration via upregulating ROCK1 expression. MCM3AP-AS1 was upregulated in patients with SCLC, and a high MCM3AP-AS1 level was accompanied by a low survival rate. Yes In SCLC cells, MCM3AP-AS1 overexpression increased ROCK1 and promoted cancer cell invasion and migration, while miR-148a overexpression showed the opposite effects and attenuated the effects of MCM3AP-AS1 overexpression on ROCK1 expression and cell behaviors. 34271873 MIAT LncRNA Homo sapiens Retinoblastoma Rb tissues and cell lines Interaction(miR-665 / LASP1) Western Blot//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay The results of the present study indicated that MIAT targeted miR-665. In Rb tissues and cell lines, high expression of MIAT was observed, whereas miR-665 was downregulated in Rb tissues. In addition, LASP1 was identified as a target gene of miR-665. Both the decreased expression of miR-665 and the elevated expression of LASP1 reversed the suppressive effects of MIAT knockdown on the proliferation and migratory and invasive abilities of Y79 cells. Furthermore, MIAT silencing attenuated the development of Rb by regulating the miR-665/LASP1 axis. Yes Furthermore, the proliferation and migratory and invasive abilities of Rb Y79 and HXO-RB44 cells were decreased following MIAT downregulation or miR-665 overexpression. 34630696 circHIPK3 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction[circHIPK3-miR-4288-ELF3 regulatory loop] qRT-PCR In this study, we identified that circular homeodomain interacting protein kinase 3 (circHIPK3) was highly expressed in NPC tissues and cell lines. In conclusion, our findings demonstrated that circHIPK3 facilitated NPC progression through protecting ELF3 from miR-4288-mediated silencing, which suggested that the circHIPK3-miR-4288-ELF3 regulatory loop might be a potential target for NPC prevention. Yes We showed that circHIPK3 silence repressed NPC cell proliferation, migration, and invasion in vitro. In addition, circHIPK3 depletion dramatically repressed tumor growth and metastasis in vivo. 30070690 MCM3AP-AS1 LncRNA Homo sapiens Prostatic Neoplasms cancerous tissues regulation[MCM3AP-AS1/miR-876-5p/WNT5A axis ] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining MCM3AP-AS1 was significantly up-regulated in cancerous tissues of prostate cancer samples, positively correlated with the expression of WNT5A, while negatively related with miR-876-5p. Besides, MCM3AP-AS1 was identified as a sponge of miR-876-5p. WNT5A was validated as a target gene of miR- 876-5p. Yes After transfection of MCM3AP-AS1 shRNA into prostate cancer cells, the proliferative ability of cancer cells was signally inhibited, but the apoptosis of cancer cells was increased. 32684844 MCM3AP-AS1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissue samples and cell lines regulation[miR-543-3p/SLC39A10/PTEN Axis ] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In PCa tissue samples and cell lines, lncRNA MCM3AP-AS1 was up-regulated while miR-543-3p was down-regulated. LncRNA MCM3AP-AS1 can promote the proliferation, migration and invasion abilities of PCa cells through regulating the miR-543-3p/SLC39A10/PTEN axis, which suggests that lncRNA MCM3AP-AS1 might be a potential target for prostate cancer therapy. Yes Over-expression of MCM3AP-AS1 could promote the proliferation and invasion of PCa cells. 33061424 MCM3AP-AS1 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues,cell lines Regulation[MCM3AP-AS1/miR-138-5p/FOXK1 axis] Western Blot//ISH//Migration Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Invasion Assay qRT-PCR results showed that MCM3AP-AS1 level was enhanced in PC tissues compared with that in adjacent normal tissues (Fig. 1a). qRT-PCR analysis further demonstrated that MCM3AP-AS1 level was higher in PC cell models (PANC-1, BxPC-3, MIA PaCa-2, Capan-2, AsPC-1) compared to that in pancreatic duct epithelial cell line (HPDE6-C7). MCM3AP-AS1 promoted growth and migration through modulating miR-138-5p/FOXK1 axis in PC, providing insights into MCM3AP-AS1/miR-138-5p/FOXK1 axis as novel candidates for PC therapy from bench to clinic. Yes MCM3AP-AS1 overexpression promoted proliferation, migration and invasion in PC cells. MCM3AP-AS1 silencing showed a suppressive effect on cell growth in PC cells. Moreover, MCM3AP-AS1 knockdown suppressed tumor growth in mice. 31830901 hsa_circ_0076305 CircRNA Homo sapiens Prostatic Neoplasms Pca tissues and cells Interaction(miR-411-5p/PGK1 axis) Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay Circ_0076305 was highly expressed in PCa.MiR-411-5p was targeted by circ_0076305, and miR-411-5p suppression counteracted the influence of circ_0076305 silencing in PCa cells. Additionally, miR-411-5p directly targeted PGK1, and miR-411-5p upregulation restrained PCa cell malignant behaviours via reducing PGK1. Yes Circ_0076305 silencing could repress cell growth, migration and glycolysis while triggered apoptosis in PCa cells. 35238066 MCF2L-AS1 LncRNA Homo sapiens Breast Neoplasms BC tumors Interaction(YAP) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Tunel//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay Herein, the bioinformatics study analysis showed that MCF2L-AS1 was frequently highly expressed in BC tumors, and this overexpression was associated with worse patient outcomes. In conclusion, MCF2L-AS1 may represent a potential predictive biomarker in BC patients, as well as a key regulator of BC cell proliferation. It works through positive feedback processes involving direct YAP binding and subsequent modulation of intracellular gene expression. Herein, the bioinformatics study analysis showed that MCF2L-AS1 was frequently highly expressed in BC tumors, and this overexpression was associated with worse patient outcomes. Yes BC cells' proliferation, migration, and invasion are inhibited when MCF2L-AS1 is silenced, whereas the inverse is evident when MCF2L-AS1 is overexpressed. It was also observed that MCF2L-AS1 knockdown decreased carcinogenesis in xenograft tumor models. 36700469 MCF2L-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues regulation[MCF2L-AS1/miR-874-3p/CCNE1 axis] qRT-PCR//RNA Pull-Down//Luciferase Report Assay We identified a novel CRC-related lncRNA, MCF2L-AS1, which is distinctly highly expressed in CRC. In addition, the newly identified MCF2L-AS1/miR-874-3p/CCNE1 axis can modulate the initiation and progression of CRC. Its diagnostic value for CRC patients was also demonstrated. Clinical assays revealed that high MCF2L-AS1 expression is associated with advanced stages, positive metastasis and the poor prognosis of CRC patients. Multivariate assays confirmed that MCF2L-AS1 expression is an independent poor prognostic factor for both 5-year overall survival and 5-year disease-free survival of CRC patients. Yes Functionally, we confirmed that knockdown of MCF2L-AS1 distinctly suppresses the proliferation, migration and invasion of CRC cells and also promotes apoptosis. 33037865 MCF2L-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-874-3p/FOXM1 signaling axis) qRT-PCR//Transwell Assay//Western Blot Herein, we observed that MCF2L-AS1 expression was enriched in CRC tissues and cell lines.Additionally, silencing of MCF2L-AS1 dramatically impeded cell proliferation, invasion and migration capacities of CRC, and distinctly attenuated the expression of invasion associated targets MMP-2 and MMP-9. Interesting, FOXM1 was identified as direct target of miR-874-3p, and positively modulated by MCF2L-AS1 through sponging miR-874-3p. Mechanistically, MCF2L-AS1 accelerated cell proliferation, invasion and glycolysis through competitively binding to miR-874-3p, leading to enhance FOXM1 expression. Yes MCF2L-AS1 apparently restricted the glucose consumption and lactate production, and downregulated GLUT1 and LDHA expression. More importantly, we predicted and verified that MCF2L-AS1 acted as a molecular sponge for miR-874-3p and inversely regulated miR-874-3p expression. 32860508 MBNL1-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction(MBNL1-AS1/ZFP36/CENPA Axis) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Colony Formation Assay The results showed that the expression levels of MBNL1-AS1 were downregulated in breast cancer tissues and cell lines. RNA pull-down assay, RIP assay, western blot assay, and qRT-PCR assay showed that MBNL1-AS1 downregulated CENPA mRNA via directly interacting with Zinc Finger Protein 36 (ZFP36) and subsequently decreased the stability of CENPA mRNA. Restoration assays also confirmed that MBNL1-AS1 suppressed the CENPA-mediated proliferation and stemness in breast cancer cells. Yes In vitro and in vivo studies demonstrated that overexpression of MBNL1-AS1 markedly inhibited BC cells proliferation and stemness. 35518784 MBNL1-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction(miR-423-5p/CREBZF axis) In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Herein, our study found that MBNL1-AS1 was down-regulated both in breast cancer tissues and cell lines, and it functioned as a tumor suppressor to inhibit cancer cell proliferation, migration, and invasion. MiR-423-5p was found to be a target of MBNL1-AS1 with an inverse relationship: an increase in miR-423-5p could counteract the inhibitory effect induced by MBNL1-AS1 on cancer cell promotion. Further, CREBZF was negatively regulated by miR-423-5p. Accordingly, CREBZF knockdown could impair the hindrance of cancer cell growth mediated by low miR-423-5p expression. Also, MBNL1-AS1 influenced the PI3K/AKT pathway, which was associated with cell proliferation and apoptosis, by regulating CREBZF. Yes Herein, our study found that MBNL1-AS1 was down-regulated both in breast cancer tissues and cell lines, and it functioned as a tumor suppressor to inhibit cancer cell proliferation, migration, and invasion. 35094653 hsa_circ_0004417 CircRNA Homo sapiens Prostatic Neoplasms PC tissues and cells Interaction(miR-1228/p-Akt and E-cadherin) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay Circ_0004417 was significantly down-regulated in PC tissues and cells (p<0.05). In addition, the results demonstrated that circ_0004417 served as a sponge for miR-1228 and regulated expressions of p-Akt and E-cadherin. Yes Functional experiments proved that circ_0004417 overexpression markedly inhibited the proliferation and invasion of PC cells (p<0.05). 33629297 hsa_circ_0001686 CircRNA Homo sapiens Prostatic Neoplasms PCa cells Interaction(miR-411-5p/SMAD3/TGFBR2) Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay The expression of circ_0001686 was up-regulated, while the expression of miR-411-5p was down-regulated in PCa cells. Molecular mechanism exploration revealed that circ_0001686 could reduce miR-411-5p, affecting the downstream target genes of SMAD3 and TGFBR2. Yes Moreover, circ_0001686 promoted cell proliferation, migration, and invasion. 34169675 MBNL1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Interaction(miR-424-5p/Smad7 axis) Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//BrdU//Colony Formation Assay//Transwell Assay In this research, qRT-PCR showed that MBNL1-AS1 was down-regulated in GC tissues and cells. Bioinformatics analysis confirmed that MBNL1-AS1 binds to miR-424-5p via negative modulation. Rescue experiments showed that decreased miR-424-5p level inhibited GC cell promotion by silencing MBNL1-AS1. Furthermore, Smad7 was identified as a target of miR-424-5p that could reverse the promotion of GC cell growth mediated by miR-424-5p. Western blot results proved that MBNL1-AS1 affected TGF-β/SMAD pathways by regulating the miR-424-5p/Smad7 axis. Yes Cell experiments and the animal study demonstrated that MBNL1-AS1 knockdown accelerated GC cell proliferation, migration, and invasion, thus restraining cell apoptosis. Meanwhile, overexpression of MBNL1-AS1 repressed GC cell promotion. 35311623 circERBB2 CircRNA Homo sapiens Gallbladder Neoplasms GBC and para-cancer tissues Regulation[circERBB2-PA2G4-TIFIA regulatory axis] Western Blot//CCK8//RIP//FISH//Luciferase Report Assay//IF Our study demonstrates that circRNA expression pattern changed tremendously during GBC development, and circERBB2 is increased significantly in GBC tissues. CircERBB2, which accumulates in nucleoli and regulates rDNA transcription, promotes GBC proliferation, in vitro and in vivo. To evaluate clinical significance of circERBB2 with respect to prognosis of GBC patients, FISH assay was performed with a tissue microarray containing 149 surgically removed primary GBC specimens. The expression level of circERBB2 was higher in 48 patients and relatively lower in other 101 patients (Fig. 7a). We compared overall survival (OS) of the two groExpression[Expression[up-expression]-expression]s and found that GBC patients with high circERBB2 expression had significantly shorter OS time (Fig. ​(Fig.7b).7b). Median survival times were 12.73 months and 8.54 months for the circERBB2-high and -low groExpression[Expression[up-expression]-expression]s, respectively (p = 0.037). Patients of the two groExpression[Expression[up-expression]-expression]s had approximately equal age and sex distribution. Yes We performed CCK8 assay and found that silencing of circERBB2 significantly impaired proliferation of SGC-996 and GBC-SD cells (Additional file 4: Figure S3b, c). In accordance with CCK8 assay, silencing of circERBB2 also impaired clone-formation ability of SGC-996 and GBC-SD cells (Additional file 4: Figure S3d), suggesting that circERBB2 is associated with proliferation of GBC cells. 31752867 circFOXP1 CircRNA Homo sapiens Gallbladder Neoplasms GBC and adjacent normal tissue Interaction[regulating PKLR ] RNA Pull-Down//qRT-PCR//RIP//Luciferase Report Assay//RNA-seq By performing RNA sequencing from GBC and paired adjacent normal tissues to analyze the circRNA candidates, we identified that circFOXP1 (hsa_circ_0008234) expression was significantly upregulated in GBC tissues and positively associated with lymph node metastasis, advanced TNM stage and poor prognosis in patients. Additionally, circFOXP1 acted as the sponge of miR-370 to regulate PKLR, resulting in promoting Warburg effect in GBC progression. By performing RNA sequencing from GBC and paired adjacent normal tissues to analyze the circRNA candidates, we identified that circFOXP (hsa_circ_0008234) expression was significantly upregulated in GBC tissues and positively associated with lymph node metastasis, advanced TNM stage and poor prognosis in patients. Yes Short hairpin RNA mediated knockdown or exogenous expression of circFOXP1 combined with in vitro assays demonstrated that circFOXP1 has pleiotropic effects, including promotion of cell proliferation, migration, invasion, and inhibition of cell apoptosis in GBC. In vivo, circFOXP1 promoted tumor growth. 31623628 circHIPK3 CircRNA Homo sapiens Gallbladder Neoplasms gallbladder cancer cells interaction[microRNA-124] qRT-PCR We show that circHIPK3 is upregulated in human gallbladder cancer cells. Together, we conclude that circHIPK3 promotes gallbladder cancer cell growth possibly by sponging miR-124. Yes Conversely, ectopic over-expression of circHIPK3 can further promote cancer cell proliferation. 29928876 NEAT1 LncRNA Homo sapiens Non-alcoholic Fatty Liver Disease NAFLD patients Interaction(miR-212-5p/GRIA3 ) Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Oil Red O Staining//ChIP LncRNA NEAT1 and GRIA3 was upregulated, while miR-212-5p was downregulated in NAFLD patients. ChIP indicated enrichment of H3K27 on NEAT1 promoter. Luciferase results indicated direct interaction of NEAT1/miR-212-5p (which was confirmed by RIP) and miR-212-5p/GRIA3. Yes FFA promoted lncRNA NEAT1 and GRIA3 expression while suppressing miR-212-5p and promoted lipid accumulation as indicated by increased oil red O staining and FAS and ACC expression. 34652536 hsa_circ_0005221 CircRNA Homo sapiens Prostatic Neoplasms PCa cells Interaction(miR-339-5p/STAT5a pathway) RNA Pull-Down//qPCR//Luciferase Report Assay The expression of hsa_circ_0005221 was significantly higher in the PCa than in the prostatic epithelial cells. Hsa_circ_0005221 enhances the progression of prostate cancer through the miR-339-5p/STAT5a pathway. Yes The proliferation, invasion and migration abilities and EMT were decreased and the apoptosis increased in the DU145 and LNCaP cells with knockdown of hsa_circ_0005221, which was just the reverse in those with overexpressed hsa_circ_0005221. 34914211 circCDR1as CircRNA Homo sapiens Prostatic Neoplasms PC-3 cell line Interaction(miR-641/XIAP regulatory axis ) Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expression of circCDR1as and XIAP was higher and the expression of miR-641 was lower in the prostate cancer cell lines compared with the normal prostate epithelial cell line. Overall, the circCDR1as/miR-641/XIAP regulatory axis plays a role in the invasion and migration of the prostate cancer PC-3 cell line. Yes After effectively reducing the expression of circCDR1as and XIAP and increasing the expression of miR-641 in PC-3 cells, the proliferation, invasion and migration of PC-3 cells were effectively inhibited. 33907579 MIAT LncRNA Homo sapiens Cholangiocarcinoma CCA tissues regulation[miR-551b-3p/CCND1 axis] qRT-PCR Moreover, TCGA-CHOL data in the GEPIA platform further revealed the upregulated expression of MIAT in CCA tissues. MIAT contributed to the growth of CCA cells by targeting miR-551b-3p/CCND1 axis. Yes Functionally, MIAT knockdown significantly inhibited cell proliferation and induced G0/G1 phase arrest as well as apoptosis in HuCCT-1 and QBC939 cells. 32064660 circXRCC5 CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-490-3p/XRCC5/CLC3) ChIP//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Transwell Assay Up-regulation of circXRCC5 was observed in glioma tissues and cell lines, and indicated poor prognosis of glioma patients. Collectively, circXRCC5 promoted glioma progression via the miR-490-3p/XRCC5/CLC3 ceRNA network, providing a novel prognostic biomarker and a prospective target for glioma treatment. Up-regulation of circXRCC5 was observed in glioma tissues and cell lines, and indicated poor prognosis of glioma patients. Yes Knockdown of circXRCC5 suppressed cell proliferation, migration and invasion, while facilitated apoptosis. 35436516 MIAT LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 32 pairs of human LSCC tissue samples and corresponding adjacent non-tumor tissues, cell lines(TU-177 and AMC-HN-8) Interaction(microRNA-613) Wound Healing Assay//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay In the present study, it was found that the expression of MIAT in LSCC tissues was markedly higher compared with that in adjacent non-tumor tissues. In addition, MIAT expression was also increased in the human LSCC cell lines TU686, TU-177 and AMC-HN-8 compared with that in normal human keratinocytes (HaCaT). Subsequently, luciferase reporter assays verified that MIAT could bind to miR-613, where a negative correlation was observed between the expression of MIAT and miR-613 in LSCC tissues. Yes Knocking down MIAT expression significantly reduced LSCC cell proliferation and inhibited colony formation, a shown by MTT and colony formation assays, respectively. MIAT knockdown also substantially inhibited the migratory and invasive abilities of LSCC cells, as shown by wound healing and Transwell invasion assays, respectively. 33603840 hsa_circ_0012129 CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-661) cell invasion assay//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay RESULTS Expression of hsa-circ-0012129 was significantly increased in glioma tissues and cell lines. A dual-luciferase reporter assay showed that hsa-circ-0012129 contained the complementary binding region with miR-661 and that hsa-circ-0012129 expression negatively regulated miR-661. Rescue experiments showed that miR-661 could reverse the effects of hsa-circ-0012129 on cell viability, cell migration and invasion of glioma cells in vitro. Yes hsa-circ-0012129 knockdown significantly suppressed the proliferation, migration, and invasion abilities of U373 and SHG44 cells. 29686222 MIAT LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues and Du145 cells Interaction( MIAT/miR-361-3p/CCAR2 ) RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay lncRNA MIAT was upregulated, while miR-361 was downregulated in the prostate cancer tissues and Du145 cells. lncRNA MIAT negatively regulated miR-361-3p expression in Du145 cells. . Downregulating lncRNA MIAT decreased the cell viability, induced the cell apoptosis, increased Bax expression, and decreased Bcl-2 expression in Du145 cells, while the effects were reversed by downregulating miR-361-3p or CCAR2 upregulation. Moreover, CCAR2 upregulation reversed the effects of miR-361-3p upregulation on Du145 cell viability and apoptosis. Yes . Downregulating lncRNA MIAT decreased the cell viability, induced the cell apoptosis, increased Bax expression, and decreased Bcl-2 expression in Du145 cells, while the effects were reversed by downregulating miR-361-3p or CCAR2 upregulation. Moreover, CCAR2 upregulation reversed the effects of miR-361-3p upregulation on Du145 cell viability and apoptosis. 36245704 circRPMS1 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Interaction[miR-20,miR-31,miR-451] cell invasion assay//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay We found that EBV-encoded circRPMS1 was increased in metastatic NPC and was associated with short survival time.Further mechanism investigation revealed that circRPMS1-meadiated NPC oncogenesis through sponging multiple miRNA and promoting epithelial-mesenchymal transition (EMT). The inhibitors of miR-203, miR-31 and miR-451 could reverse the effects of circRPMS1 knockExpression[down-expression] on NPC cells. We found that EBV-encoded circRPMS1 was increased in metastatic NPC and was associated with short survival time. Yes KnockExpression[down-expression] of circRPMS1 inhibited cell proliferation, induced apoptosis and repressed cell invasion in EBV-positive NPC cells. 31695488 mc-COX2 CircRNA Homo sapiens Leukemia, Lymphocytic, Chronic, B-Cell blood Expression[highly expressed] Northern Blot//ISH//qPCR//FISH//Cell Apoptosis Assay//Microarray//PCR In this study, we attempted to identify the novel characteristics of mc-COX2 (mitochondrial genome-derived circRNAs [mc]), one of the mt-circRNAs that can be involved in CLL progression. mt-circRNAs were found to be highly expressed in the plasma exosomes of CLL patients. The upregulation of mc-COX2 was positively associated with leukemogenesis and worsening survival of CLL patients Yes The endogenous reduction of mc-COX2 can affect mitochondrial functions, suppress cell proliferation, and induce cell apoptosis. 32438315 MCF2L-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC cell Interaction(miR-105-5p/RAB22A axis) RNA Pull-Down//Flow Cytometry//qRT-PCR//FISH//RIP//Transwell Assay MCF2L-AS1 was highly expressed in CRC cells, and it could enhance the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process of CRC cells. MiR-105-5p was sponged by MCF2L-AS1 in CRC cells Yes Ras-related protein Rab-22A (RAB22A) was verified to be the downstream target of miR-105-5p. It was verified through rescue assays that RAB22A overexpression or miR-105-5p silencing could reverse the repressive impact of MCF2L-AS1 silencing on CRC progression. 34592939 MCM3AP-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary papillary thyroid cancer tissues and cells Regulation[miR-211-5p/SPARC axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay In papillary thyroid cancer, MCM3AP-AS1 was upregulated, while miR-211 was downregulated.MCM3AP-AS1 promotes papillary thyroid cancer by regulating the MCM3AP-AS1/miR-211-5p/SPARC axis, which could potentially be a therapeutic target in papillary thyroid cancer. Yes MCM3AP-AS1 overexpression promoted papillary thyroid cancer proliferation, migration, and invasion. 31030335 circTGFBR2 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissue interaction[sponging miR-107] IHC//Western Blot//ISH//Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Furthermore, the expression of circTGFBR2 was downregulated in NPC tissue samples, while circTGFBR2 overexpression correlated with favorable prognosis in NPC.Further analysis showed that circTGFBR2 sponged miR-107, leading to the upregulation of TGFBR2 expression and suppression of NPC progression. Yes Functionally, circTGFBR2 overexpression inhibited the proliferation and migration of NPC cells both in vitro and in vivo. 33160003 MCM3AP-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells regulation[miR-204-5p/FOXC1] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay MCM3AP-AS1 expression was elevated in OSCC tissues and cell lines.MCM3AP-AS1 promotes the progression of OSCC cells by adsorbing miR-204-5 p and upregulating FOXC1 expressions. Yes Overexpression of MCM3AP-AS1 facilitated the proliferation, migration and invasion of OSCC cells, while the knockdown of MCM3AP-AS1 suppressed these malignant phenotypes. 32690597 NEAT1 LncRNA Homo sapiens Coronary Artery Disease blood,human coronary endothelial cells regulation[miR-140-3p/MAPK1 pathway] Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Colony Formation Assay The results showed that NEAT1 was up-regulated in CAD blood samples and in human coronary endothelial cells (HCAECs). Our results revealed that lncRNA NEAT1 increased cell viability and inhibited CAD cell apoptosis possibly by activating the miR-140-3p/MAPK1 pathway, and lncRNA NEAT1 might serve as a potential therapeutic target for CAD. Yes Transfection of pcNEAT1 significantly inhibited the survival rate of HCAECs and induced apoptosis of HCAECs. 32844995 hsa_circ_0086722 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Interaction( miR-339-5p/STAT5A axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//EdU Staining//Transwell Assay Results revealed that circ_0086722 was highly expressed in PCa tissues and cell lines.Moreover, we demonstrated that circ_0086722 could mechanistically relieve the repressive effects of miR-339-5p on its target STAT5A, which facilitates PCa development. In conclusion, our findings revealed that circ_0086722 drives PCa development via the miR-339-5p/STAT5A axis, and it may function as a potential prognostic biomarker or therapeutic target for PCa treatment. Furthermore, high levels of circ_0086722 were positively correlated with pT3 stage, higher specimen Gleason score (>7), and worse biochemical recurrence-free survivals of PCa patients. Yes Then, functional experiments revealed that circ_0086722 accelerated PCa proliferation and progression. 35227787 MCTP1-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and cell lines Interaction(miR-650/SMAD7 Axis) Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay//Transwell Assay Our data showed that MCTP1-AS1 expression was downregulated in EC tissues and cell lines. Moreover, MCTP1-AS1 was proved to be the target of miR-650 and reversely correlated with its expression. In addition, MCTP1-AS1 reversed the effect of miR-650 on the EC cells, which might be associated with the role of SMAD7. Moreover, Western blot showed siRNA-SMAD7 transfection could rescue the repressed TGF-β/SMAD pathway induced by MCTP1-AS1 in EC cells. Yes Overexpression of MCTP1-AS1 inhibited cell proliferation, migration, invasion and EMT process of EC cells. 33568915 hsa_circ_0070512 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(miR-338-3p/hedgehog signaling pathway) In Vivo Experiment//ISH//CCK8//Luciferase Report Assay//Transwell Assay "hsa_circ_0070512 was increased in PCa tissues and cells and was mostly found in the cytoplasm of PCa cells. Mechanistically, we show that hsa_circ_0070512 acts as a ""molecular sponge"" for miR-338-3p and that the miR-338-3p mimics partially block the pro-tumor effects of hsa_circ_0070512. RNA sequencing analysis of PC3 cells stably overexpressing hsa_circ_0070512 revealed that hedgehog was downstream of the signaling pathways of hsa_circ_0070512 and miR-338-3p." Yes Overexpression of hsa_circ_0070512 considerably increased PCa cell proliferation and migration, whereas silencing of hsa_circ_0070512 greatly decreased PCa cell proliferation and migration. 36411517 MDFIC-7 LncRNA Homo sapiens Chordoma chordoma tumor tissues Interaction( miR-525-5p/ARF6 Axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis The expression of lncRNA MDFIC-7 was higher in chordoma tumor tissues than in adjacent non-tumor tissues. Mechanistically, lncRNA MDFIC-7, as a molecular sponge of miR-525-5p, negatively regulated miR-525-5p expression and promoted the gene expression of ARF6, a miR-525-5p target. Yes Downregulation of lncRNA MDFIC-7 reduced colony formation and cell proliferation in chordoma cells and decreased xenograft tumor growth in a nude mouse model. Moreover, lncRNA MDFIC-7 knockdown attenuated the Warburg effect in chordoma cells and xenograft tumors. 34621682 circDPP4 CircRNA Homo sapiens Prostatic Neoplasms 60 patients and PC cell lines Interaction( miR-564/ZIC2 axis) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//CCK8//qRT-PCR//Flow Cytometry//MTT//Colony Formation Assay//Transwell Assay Expression of circDPP4 is upregulated in PC tumors from 60 patients and PC cell lines, and a higher circDPP4 might predict poor overall survival. Mechanistically, circDPP4 functions as a miR-564 sponge and regulates the expression of ZIC2, a target gene for miR-564. Tumor growth is retarded by silencing circDPP4, accompanied by elevated miR-564 and attenuated Ki-67 and ZIC2. Expression of circDPP4 is upregulated in PC tumors from 60 patients and PC cell lines, and a higher circDPP4 might predict poor overall survival. Yes Decreasing circDPP4 suppresses cell proliferation, colony formation, migration/invasion, and 50% inhibitory concentration of DTX in PC cells, and promotes the apoptosis rate. Both overexpressing miR-564 and inhibiting ZIC2 could imitate those effects, whereas inhibiting miR-564 and restoring ZIC2 could separately counteract them. 34904327 MDHDH LncRNA Homo sapiens Glioblastoma clinical samples of GBM and LGG Interaction(MDH2 and PSMA1) ChIP//Western Blot//Wound Healing Assay//Co-IP//FISH//qRT-PCR//RIP//RNA-seq//Cell Proliferation Assay//Transwell Assay In public datasets, MDHDH expression was significantly downregulated in GBM and LGG compared with GTEx normal brain tissues. Mechanistically, we found that MDHDH directly bound to MDH2 and PSMA1 (20S proteasomal core subunit alpha-type 1) as a molecular scaffold and accelerated the degradation of MDH2 by promoting the binding of ubiquitinated MDH2 to the proteasome. The degradation of MDH2 subsequently led to changes in the mitochondrial membrane potential and NAD+/NADH ratio, which impeded glycolysis in glioma cells. The results of the tissue microarray showed that the MDHDH expression level negatively correlated with the tumor grade. Yes Altered MDHDH expression led to significant changes in the proliferation, migration and invasion of GBM cells both in vitro and in vivo. 36527092 Mdrl LncRNA Mus musculus Atherosclerosis mouse atherosclerotic plaques Interaction(miR-361/SQSTM1/NLRP3) Western Blot//Transfection//Tunel//qRT-PCR//RIP//Luciferase Report Assay//IHC Downregulated MDRL and increased NLRP3 were observed in mouse atherosclerotic plaques, accompanied with the increase of miR-361. Mechanically, MDRL suppressed NLRP3 inflammasome activation and VSMC apoptosis via suppressing miR-361. Furthermore, miR-361 directly bound to the 3'UTR of SQSTM1 and inhibited its translation, subsequently activating NLRP3 inflammasome. Yes The results showed that MDRL overexpression significantly attenuated the burden of atherosclerotic plaque and facilitated plaque stability through inhibiting NLRP3 inflammasome activation and cell apoptosis, and vice versa. Systematic delivery of miR-361 partly counteracted the beneficial effects of MDRL overexpression on atherosclerotic development in LDLR-/- mice. 36186576 hsa_circ_0046263 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC cell lines and tissues regulation[miR-133a-5p/IGFBP3 axis] Western Blot//Wound Healing Assay//qRT-PCR//RIP//FISH//Transwell Assay Circ-0046263 was upregulated in both NPC cell lines and tissues. Finally, circ-0046263 plays a tumor-promoting role in NPC to enhance malignant behavior through the miR-133a-5p/IGFBP3 axis, which could be a potential target for NPC therapy. Yes The in vitro functional studies revealed that knockdown of circ-0046263 inhibited the proliferation, invasion, and migration of NPC cells, whereas its overexpression produced the opposite result. 32703944 hsa_circ_0066755 CircRNA Homo sapiens Nasopharyngeal carcinoma plasma and tissues regulation[hsa_circ_0066755 / miR-651 axis] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay We found significant increases of hsa_circ_0066755 in the plasma and tissues of the patients. Collectively, this study reported for the first time that hsa_circ_0066755 played a role of oncogene in NPC and could be used as an effective diagnostic marker for NPC, and that hsa_circ_0066755 / miR-651 axis also involved in the progression of NPC. Moreover, its levels were positively correlated with clinical staging (P=0.019). The receiver operating characteristic (ROC) analysis showed that the area under the curves (AUCs) of tissue and plasma hsa_circ_0066755 for distinguishing NPC from non-cancerous controls were 0.8537 and 0.9044, respectively. Yes Our in-vitro experiment showed that the overexpression of hsa_circ_0066755 facilitated the growth, proliferation, clone formation, invasion and migration of CNE-1 NPC cells, while its down-regulation showed completely opposite effects. The xenograft experiment showed that exogenous hsa_circ_0066755 could significantly enhance the in-vivo tumorigenic ability of CNE-1 cells. 32669952 MEF2C-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and CC cells Interaction( miR-592/RSPO1 ) Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay The data from GEPIA website showed that lncRNA MEF2C-AS1 expression was down-regulated in CC tissues and also associated with survival rate of CC patients. Moreover, the results of qRT-PCR also showed lncRNA MEF2C-AS1 was lowly expressed in CC cells. Further research illustrated that lncRNA MEF2C-AS1 was the target of miR-592, and RSPO1 was the downstream target gene of miR-592. Yes Subsequently, we confirmed that overexpression of lncRNA MEF2C-AS1 inhibited the proliferation, migration and invasion of CC cells. 34169096 NEAT1 LncRNA Homo sapiens Liver Cirrhosis fibrotic liver tissues Interaction(miR-139-5p/ β-catenin/SOX9/TGF-β1 Pathway) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Transfection//Migration Assay//Flow Cytometry//FISH//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//IP//IHC//IF Our results demonstrated that the expression of lncRNA NEAT1 was increased and the expression of miR-139-5p was decreased in fibrotic liver tissues.LncRNA NEAT1 could sponge miR-139-5p and promoted hepatic stellate cells (HSCs) activation by directly inhibiting the expression of miR-139-5p. The co-localization of lncRNA NEAT1 with miR-139-5p was shown in the cytosols of activated HSCs. LncRNA NEAT1 exacerbated liver fibrosis by suppressing the expression of miR-139-5p. Collectively, our study suggested that miR-139-5p sponged by lncRNA NEAT1 regulated liver fibrosis via targeting β-catenin/SOX9/TGF-β1 Pathway. Yes miR-139-5p upregulation could suppress the expression of β-catenin. The overexpression of β-catenin promoted HSCs activation. Moreover, we found that β-catenin could interact with SOX9 promoted HSCs activation. Our further studies demonstrated that SOX9 could bind with the TGF-β1 promoter and promoted the transcription activity of TGF-β1. The upregulation of TGF-β1 further promoted HSCs activation. In vivo study also suggested that lncRNA NEAT1 knockdown and miR-139-5p overexpression alleviated murine liver fibrosis. 34531378 NEAT1 LncRNA Homo sapiens Heart Defects, Congenital blood Interaction[PI3K/AKT/mTOR] CCK8//qRT-PCR//Cell Apoptosis Assay//Western Blot Additionally, we subsequently tested the expression of NEAT1 and miR-181b in the blood samples from CHD patients. We discovered that the expression levels of NEAT1 and miR-181b were significantly decreased in CHD group as relative to that in healthy group. The decreased NEAT1 and miR-181b were showcased in hypoxia and blood samples from CHD; meanwhile, elevated miR-181b evoked by overexpressed NEAT1 was observed in hypoxia-managed H9c2 cells. More importantly, miR-181b inhibition obviously overturned the influences of NEAT1 in hypoxia-affected H9c2 cells apoptosis and autophagy. Besides, overexpressed NEAT1 facilitated PI3K/AKT/mTOR and JAK1/STAT3 activations via enhancing miR-181b. The research exposed that NEAT1 eased hypoxia-triggered H9c2 cells apoptosis and autophagy by expediting PI3K/AKT/mTOR and JAK1/STAT3 pathways via elevating miR-181b. Yes Overexpressed NEAT1 clearly allayed hypoxia-triggered H9c2 cells apoptosis and autophagy. 31853799 circPHF16 CircRNA Homo sapiens Prostatic Neoplasms prostate cancer (PCa) tissues and cells Interaction(miR-581/RNF128/Wnt/β-catenin pathway) In Vivo Experiment//RNA Pull-Down//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay Here, we identified that circPHF16 was downregulated in prostate cancer (PCa) tissues compared with normal tissues. Mechanistically, circPHF16 directly interacted with miR-581, leading to the downregulation of ring finger protein 128 (RNF128) and inhibiting the metastatic ability of PCa. Furthermore, circPHF16-dependent upregulation of RNF128 inactivated Wnt/β-catenin signaling. In total, our findings revealed that circPHF16 suppressed prostate cancer metastasis through the circPHF16/miR-581/Wnt/β-catenin pathways. Yes Functionally, circPHF16 restrained prostate cancer metastasis both in vivo and in vitro. 36503162 hsa_circ_0010235 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(circ_0010235/miR-1249-3p/HOXA13 Axis) In Vivo Experiment//RNA Pull-Down//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay Circ_0010235 was significantly overexpressed in human LUAD. Mechanistically, circ_0010235 targeted and inhibited miR-1249-3p. Moreover, circ_0010235 depletion repressed cell malignant behaviors by upregulating miR-1249-3p. HOXA13 was identified as a direct and functional target of miR-1249-3p. Furthermore, circ_0010235 regulated HOXA13 expression by competing for shared miR-1249-3p. Yes Silencing of circ_0010235 hindered LUAD cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro, as well as diminished tumor growth in vivo. 35076814 MEF2C-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Epigenetics(Hypermethylation ) qRT-PCR//Wound Healing Assay//Transwell Assay Lower expression and higher methylation of MEF2C-AS1 were found in CRC by online databases. In the comparisons of lesion tissues with adjacent normal tissues, MEF2C-AS1 hypermethylation of each individual site and mean level was found among CRC patients in in-house step 1 and step 2, more meaningfully, among NAA patients, AA patients, and CRC patients at all stages during colorectal carcinogenesis in in-house step 3 (all p < 0.05). Further comparisons demonstrated significant differences between CRC and NAA (p = 0.025), AA and NAA (p = 0.020). Moreover, MEF2C-AS1 hypermethylation was associated with poorer disease-specific survival of CRC patients (p = 0.044). Yes In addition, hypermethylation and lower expression of MEF2C-AS1 were verified in RKO cells, and the MEF2C-AS1 overexpression significantly suppressed RKO cell proliferation, migration, and invasion. 36064442 Meg3 LncRNA Rattus norvegicus Diabetic Brain Ischemic Injury RBMVECs Interaction(p53/GPX4 axis) Western Blot//Transfection//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//ChIP by modulating GPX4 transcription and expression, the Meg3-p53 signaling pathway mediated the ferroptosis of RBMVECs upon injury induced by OGD combined with hyperglycemic reperfusion. Yes GPX4 expression was suppressed again after the reintroduction of p53 into cells silenced by Meg3 34587716 Meg3 LncRNA Rattus norvegicus Neuralgia CCI rats and LPS-induced astrocytes Interaction(miR-130a-5p/CXCL12/CXCR4 axis) In Vivo Experiment//Western Blot//Transfection//Tunel//qRT-PCR//ELISA//IHC MEG3, CXCL12 and CXCR4 were overexpressed and miR-130a-5p was knocked down in CCI rats and LPS-induced astrocytes. AS verified by the dual-luciferase reporter assay and RIP assay, MEG3 sponged miR-130a-5p as a competitive endogenous RNA (ceRNA). What's more, miR-130a-5p up-regulation weakened the MEG3-induced proinflammatory effects on LPS-induced astrocytes. Yes Up-regulating MEG3 aggravated NP, enhanced inflammatory cytokines interleukin-1β (IL-1β), tumor necrosis factor (TNF)-α, and interleukin-6 (IL-6) expression and release in CCI rats and LPS-induced astrocytes. Up-regulating miR-130-5p repressed LPS-induced inflammation in astrocytes. 34609952 hsa_circ_0003258 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(hsa_circ_0003258/miR-653-5p/ARHGAP5 axis or hsa_circ_0003258/IGF2BP3 /HDAC4 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//FISH//IF//RIP//Luciferase Report Assay//Transwell Assay Increased expression of hsa_circ_0003258 was found in PCa tissues and was associated with advanced TNM stage and ISUP grade. Mechanistically, hsa_circ_0003258 could elevate the expression of Rho GTPase activating protein 5 (ARHGAP5) via sponging miR-653-5p. In addition, hsa_circ_0003258 physically binds to insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) in the cytoplasm and enhanced HDAC4 mRNA stability, in which it activates ERK signalling pathway, then triggers EMT programming and finally accelerates the metastasis of PCa. Increased expression of hsa_circ_0003258 was found in PCa tissues and was associated with advanced TNM stage and ISUP grade. Yes Overexpression of hsa_circ_0003258 promoted PCa cell migration by inducing epithelial mesenchymal transformation (EMT) in vitro as well as tumor metastasis in vivo, while knockdown of hsa_circ_0003258 exerts the opposite effect. 34986849 OIP5-AS1 LncRNA Homo sapiens Osteoarthritis cartilage tissues Interaction(micro-30a-5p) Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay LncRNA OIP5-AS1 in cartilage tissues of patients with OA decreased, while micro-30a-5p in them increased and increased with apoptosis. Yes Down-regulation of lncRNA OIP5-AS1 gave rise to increased micro-30a-5p, and up-regulation of micro-30a-5p or down-regulation of lncRNA OIP5-AS1 brought about cell apoptosis and inflammatory response, and inhibited cell proliferation, while up-regulation of micro-30a-5p suppressed cell apoptosis and inflammatory response, and accelerated cell proliferation.LncRNA OIP5-AS1 affected chondrocytes by negatively regulating micro-30a-5p. 33629291 MCM3AP-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues regulation[miR-28-5p/CENPF axis] qRT-PCR By searching GEO and TCGA database, we found that CENPF was upregulated in breast cancer tissues. All results indicated that MCM3AP-AS1/miR-28-5p/CENPF axis accelerates breast cancer progression. Yes Functional experiments revealed that CENPF had positive effect on the cellular functions, including proliferation, migration and invasion. 32485570 MCM3AP-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck tissues and cells regulation[inhibiting miR-363-5p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay RT-qPCR analysis demonstrated significantly higher MCM3AP-AS1 expression in tumor tissues or OSCC cells compared with normal tissues or human oral keratinocytes cells (P<0.05). MCM3AP-AS1 promoted OSCC cells proliferation, migration and invasion by inhibiting miR-363-5p. A high MCM3AP-AS1 level was associated with poor prognosis in OSCC patients (P<0.05 or P<0.01). Yes Compared to the small interfering (si)-negative control (NC) group, OSCC cells of si-MCM3AP-AS1 group exhibited markedly lower optical density (at 450 nm) value and relative migration and invasion (P<0.05). miR-363-5p was directly inhibited by MCM3AP-AS1. OSCC cells of si-MCM3AP-AS1 + inhibitor-NC group exhibited clearly lower relative proliferation, migration and invasion compared with cells of si-NC + inhibitor-NC group and si-MCM3AP-AS1 + miR-363-5p inhibitor group (P<0.05). 32742341 MCM3AP-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation[ miR-194-5p/FOXA1 axis ] RNA Pull-Down//CCK8//qRT-PCR//FISH//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining We revealed a novel oncogenic lncRNA MCM3AP-AS1, which is overexpressed in HCC and positively correlated with large tumor size, high tumor grade, advanced tumor stage and poor prognosis of HCC patients.Mechanistically, MCM3AP-AS1 directly bound to miR-194-5p and acted as competing endogenous RNA (ceRNA), and subsequently facilitated miR-194-5p's target gene forkhead box A1 (FOXA1) expression in HCC cells. Interestingly, FOXA1 restoration rescued MCM3AP-AS1 knockdown induced proliferation inhibition, G1 arrest and apoptosis of HCC cells. We revealed a novel oncogenic lncRNA MCM3AP-AS1, which is overexpressed in HCC and positively correlated with large tumor size, high tumor grade, advanced tumor stage and poor prognosis of HCC patients. Yes MCM3AP-AS1 knockdown suppressed HCC cell proliferation, colony formation and cell cycle progression, and induced apoptosis in vitro, and depletion of MCM3AP-AS1 inhibited tumor growth of HCC in vivo. 30782188 MCM3AP-AS1 LncRNA Homo sapiens Osteoarthritis OA and normal cartilage tissues&chondrocyte cell lines Interaction(miR-138-5p/SIRT1) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA//Transwell Assay It was found that MCM3AP-AS1 was declined in OA cartilage tissues, positively interrelated with SIRT1 expression while negatively correlated with miR-138-5p. MCM3AP-AS1 up-regulation enhanced the viability and migration of CHON-001 and ATDC5 cells while restraining the apoptosis and inflammatory response. Additionally, miR-138-5p overexpression counteracted the effects on chondrocytes caused by MCM3AP-AS1 overexpression. MCM3AP-AS1 could adsorb miR-138-5p, and SIRT1 was verified as a target of miR-138-5p, and SIRT1 could be up-regulated by overexpression of MCM3AP-AS1 indirectly. Yes MCM3AP-AS1 up-regulation enhanced the viability and migration of CHON-001 and ATDC5 cells while restraining the apoptosis and inflammatory response. 33942704 NEAT1 LncRNA Homo sapiens Non-alcoholic Fatty Liver Disease Regulation(mTOR/S6K1 signaling pathway) In Vivo Experiment//Western Blot The level of NEAT1 expression and the mRNA levels of ACC and FAS were obviously enhanced in NAFLD model both in vivo and in vitro. Knockdown of NEAT1 could also reduce the elevation of ACC and FAS induced by FFA in liver cells. Moreover, inhibition of mTOR/S6K1 pathway presented with the same effect with knockdown of NEAT1 on the expression of ACC and FAS mRNA levels. Yes The injection of si-NEAT1 lentivirus was performed to treat NAFLD of rats and the obvious efficacy for NAFLD rats was achieved. 28771824 hsa_circ_0006156 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(S100A9) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Colony Formation Assay//Transwell Assay Hsa_circ_0006156 (subsequently named circ_0006156) expresses at low levels in both PCa tissues and cells, and it significantly inhibits the migration and invasion of PCa cells.Circ_0006156 binds to and blocks the ubiquitination of S100A9. Moreover, functional assays revealed that circ_0006156 represses the malignant progression of PCa by binding to S100A9. Yes Hsa_circ_0006156 (subsequently named circ_0006156) expresses at low levels in both PCa tissues and cells, and it significantly inhibits the migration and invasion of PCa cells.Finally, in vivo experiments showed that circ_0006156 suppresses PCa migration and invasion by increasing S100A9, revealing circ_0006156 as a potential novel effective target for PCa treatment. 35760899 circPDHX CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(miR-497-5p/ACSL1 axis) In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay CircPDHX and ACSL1 contents were upregulated, and the miR-497-5p level was downregulated in PCa. CircPDHX bound to miR-497-5p to adjust ACSL1. Moreover, miR-497-5p inhibited the PCa progression by regulating ACSL1. Yes CircPDHX deficiency attenuated PCa cell proliferation, migration, and fatty acid metabolites, while intensified cell apoptosis. In the meantime, circPDHX deficiency repressed PCa tumor growth in vivo. 35777132 MCM3AP-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(MCM3APAS1/ miR-218/GLUT1 pathway) qRT-PCR//FISH//Luciferase Report Assay//Western Blot MCM3AP-AS1 accumulated to high levels in PTC tissues and was affected by clinical stage.MCM3AP-AS1 showed a positive correlation with GLUT1 across PTC tissues. RNA interaction prediction showed that MCM3AP-AS1 could bind to miR-218, which can directly target GLUT1. Yes RNA interaction prediction showed that MCM3AP-AS1 could bind to miR-218, which can directly target GLUT1. 35929906 MCM3AP-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC patients, CRC cells Regulation(VEGF and VEGFR2 ) qRT-PCR//MTT//Western Blot//Transwell Assay Before therapy, CRC patients presented a higher MCM3AP-AS1 level than healthy individuals (P < 0.05), and the sensitivity and specificity of MCM3AP-AS1 in predicting the occurrence of CRC were 65.12% and 83.33%, respectively (P < 0.001). Moreover, the VEGF and VEGFR2 mRNA levels were increased in CRC cells, and VEGF/VEGFR2 pathway-associated proteins were inhibited in the sh-MCM3AP-AS1 group (P < 0.05). After therapy, CRC patients presented a decrease in MCM3AP-AS1 levels, and recurrence was higher in patients who died (P < 0.05). Additionally, the high MCM3AP-AS1 expression group presented a higher mortality than the low MCM3AP-AS1 expression group (P < 0.05). Yes In an in vitro assay, CRC cells showed a higher MCM3AP-AS1 level than CCD-18Co cells, and the sh-MCM3AP-AS1 group presented decreased cell proliferation and invasiveness, whereas the levels apoptosis-associated proteins were increased (P < 0.05). 36172487 hsa_circ_0044516 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(miR-330-5p/SARM1 axis) Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0044516 and SARM1 were highly expressed, while miR-330-5p was rarely expressed in PCa tissues and cells. Circ_0044516 acted as a miR-330-5p sponge to block miR-330-5p expression, and circ_0044516 knockdown suppressed PCa cell proliferation, migration, invasion, and cycle progression by enriching miR-330-5p. SARM1 was a target of miR-330-5p, and miR-330-5p restoration also inhibited PCa cell proliferation, migration, invasion, and cycle progression by degrading SARM1. Moreover, circ_0044516 deficiency blocked tumor growth in vivo by regulating the miR-330-5p/SARM1 axis. Yes Circ_0044516 acted as a miR-330-5p sponge to block miR-330-5p expression, and circ_0044516 knockdown suppressed PCa cell proliferation, migration, invasion, and cycle progression by enriching miR-330-5p. SARM1 was a target of miR-330-5p, and miR-330-5p restoration also inhibited PCa cell proliferation, migration, invasion, and cycle progression by degrading SARM1. Moreover, circ_0044516 deficiency blocked tumor growth in vivo by regulating the miR-330-5p/SARM1 axis. 34993722 MCM3AP-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC cells Interaction(microRNA-599/ARPP19 axis) CCK8//qRT-PCR//Luciferase Report Assay//Migration Assay MCM3AP-AS1 was identified as a molecular sponge of miR-599, and further investigation indicated that MCM3AP-AS1 silencing inhibited cell proliferation and migration of the CRC cell lines. In addition, ARPP19 was identified as a target gene of miR-599, and MCM3AP-AS1-knockdown decreased ARPP19 mRNA expression and increased miR-599 expression.. The results also demonstrated that MCM3AP-AS1 promoted CRC cell progression by regulating the miR-599/ARPP19 axis. Yes MCM3AP-AS1 was identified as a molecular sponge of miR-599, and further investigation indicated that MCM3AP-AS1 silencing inhibited cell proliferation and migration of the CRC cell lines. 33613714 MCM3AP-AS1 LncRNA Homo sapiens Colorectal Neoplasms 53 cases of CRC and its adjacent normal tissues Interaction(miR-19a-3p/FOXF2 axis) CCK8//qRT-PCR MCM3AP-AS1 expression was down-modulated in CRC, and its dysregulation was linked to unfavorable pathological characteristics. MCM3AP-AS1 was recognized as a molecular sponge to suppress miR-19a-3p expression, and FOXF2 was a target gene of miR-19a-3p. MCM3AP-AS1 positively modulated FOXF2 expression, and its biological effect was dependent the on miR-19a-3p/FOXF2 axis. Yes MCM3AP-AS1 significantly impeded the multiplication and migration of CRC cells. 33450091 MIAT LncRNA Homo sapiens Melanoma melanoma tissues Regulation[PI3K/AKT signaling pathway] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay The lncRNA MIAT was overexpressed in melanoma. MIAT significantly upregulated the phosphorylation of PI3K and AKT and promoted cMyc and cyclin D1 protein expression. Yes The overexpression of MIAT promoted cell proliferation, cell invasion and migration, while the knockdown of MIAT expression got the opposite results. 30614798 circSCAF8 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(circSCAF8-miR-140-3p/miR-335-LIF pathway) In Vivo Experiment//Western Blot//FISH//qRT-PCR//Cell Proliferation Assay//IHC//Transwell Assay Mechanistically, circSCAF8 can function by binding to both miR-140-3p and miR-335 to regulate LIF expression and activate the LIF-STAT3 pathway that leads to the growth and metastasis of PCa. Collectively, our findings demonstrate that circSCAF8 contributes to PCa progression through the circSCAF8-miR-140-3p/miR-335-LIF pathway. Yes . We found that the knockdown of circSCAF8 in PCa cells suppressed the proliferation, migration, and invasion ability, while overexpression of circSCAF8 had the opposite effects. Similar results were observed in vivo. 35654787 hsa_circ_0081534 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines regulation[miR-508-5p/FN1 axis] RNA Pull-Down//Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In this study, we identified a circRNA hsa_circ_0081534 was significantly upregulated in NPC tissues and cell lines. Therefore, hsa_circ_0081534 promoted the proliferation, and invasion of NPC cells via regulating the miR-508-5p/FN1 axis. Yes Inhibition of hsa_circ_0081534 induced a decrease in NPC cells proliferation and invasion in vitro, and repressed tumor growth in vivo. 33082297 MCM3AP-AS1 LncRNA Homo sapiens Lung Neoplasms cell lines Regulation[miR-340-5p/KPNA4 axis] qRT-PCR At first, MCM3AP-AS1 expression was found to be elevated in lung cancer cells. Conclusively, the YY1-mediated overexpression of MCM3AP-AS1 accelerated angiogenesis and progression in lung cancer by targeting miR-340-5p/KPNA4 axis, which highlighted the possibility of MCM3AP-AS1 as a promising therapeutic target for lung cancer. Yes Depletion of MCM3AP-AS1 repressed cell proliferation, migration, and angiogenesis in lung cancer cells. 31693222 circSPON2 CircRNA Homo sapiens Prostatic Neoplasms PCa patients and cells Interaction(miR-331-3p/PRMT5) In Vivo Experiment//RNA Pull-Down//IHC//ChIP//Western Blot//Wound Healing Assay//H&E Staining//Migration Assay//FISH//qRT-PCR//Luciferase Report Assay//Microarray//Colony Formation Assay//Transwell Assay Moreover, the expression of circSPON2, a candidate circRNA in PCa tissues identified by RNA-seq, was found to be associated with poor clinical outcomes in PCa patients. Particularly, circSPON2 acted as a competitive endogenous RNA (ceRNA) of miR-331-3p to attenuate the repressive effects of miR-331-3p on its downstream target PRMT5. Our findings showed that the epigenetic regulator PRMT5 aggravates PCa progression by inhibiting the transcription of CAMK2N1 and is modulated by the circSPON2/miR-331-3p axis, which may serve as a potential therapeutic target for patients with aggressive PCa. Moreover, the expression of circSPON2, a candidate circRNA in PCa tissues identified by RNA-seq, was found to be associated with poor clinical outcomes in PCa patients. Yes Further results showed that circSPON2 induced PCa cell proliferation and migration, and that the circSPON2-induced effects were counteracted by miR-331-3p. 35624451 circKDM4A CircRNA Homo sapiens Prostatic Neoplasms serum exosomes Interaction( miR-338-3p/CUL4B) In Vivo Experiment//IHC//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay CircKDM4A expression was significantly upregulated in the serum exosomes from PC patients compared with the exosomes from healthy volunteers. Additionally, circKDM4A acted as a miR-338-3p sponge, and miR-338-3p bound to CUL4B in PC cells. CircKDM4A regulated the effect of exosome-induced PC cell malignancy by interacting with miR-338-3p and CUL4B. Yes Exosomes treatment promoted the proliferation, migration and invasion of PC cells but inhibited apoptosis; however, these effects were attenuated after circKDM4A knockdown. 35930171 NEAT1 LncRNA Homo sapiens Skin Neoplasms CSCC tissues and cells Expression(highly expressed) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//MTT//Colony Formation Assay Changes in lncRNA NEAT1 expression in CSCC tissues were correlated with the degree of lymph node metastasis and the tumor, regional lymph nodes, and distant metastasis (TNM) grade of patients. The downregulation of NEAT1 lncRNA significantly impeded cell invasion, proliferation, and migration in CSCC. Through lncRNA NEAT1 knockdown, significant reductions in metalloproteinase-2, metalloproteinase-9, N-cadherin, and vimentin expression were observed, and the level of E-cadherin increased. In vivo experiments in nude mice revealed that knockdown of lncRNA NEAT1 greatly inhibited cell proliferation in CSCC. In CSCC tissues, NEAT1 lncRNA was expressed at high levels and correlated with lymph node metastasis and TNM stage. Changes in lncRNA NEAT1 expression in CSCC tissues were correlated with the degree of lymph node metastasis and the tumor, regional lymph nodes, and distant metastasis (TNM) grade of patients. Yes The downregulation of NEAT1 lncRNA significantly impeded cell invasion, proliferation, and migration in CSCC. Through lncRNA NEAT1 knockdown, significant reductions in metalloproteinase-2, metalloproteinase-9, N-cadherin, and vimentin expression were observed, and the level of E-cadherin increased. In vivo experiments in nude mice revealed that knockdown of lncRNA NEAT1 greatly inhibited cell proliferation in CSCC. 35282061 MCM3AP-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction(ZFP36) RNA Pull-Down//Western Blot//Wound Healing Assay//Tunel//Flow Cytometry//qRT-PCR//RIP//MTT//Colony Formation Assay//Transwell Assay We found that lncRNA MCM3AP-AS1 was significantly upregulated in breast cancer, which correlated with patients' clinicopathological characteristics. Further analysis clarified that MCM3AP-AS1 binds with the RNA-binding protein ZFP36 ring finger protein (ZFP36) to regulate the levels of cyclin D1 (CCND1), c-myc (MYC), and matrix metalloproteinase 1 (MMP1). We found that lncRNA MCM3AP-AS1 was significantly upregulated in breast cancer, which correlated with patients' clinicopathological characteristics. Yes Downregulation of MCM3AP-AS1 substantially inhibited the proliferation, apoptosis, migration, and invasion of breast cancer cells. 35116304 hsa_circ_0008450 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC cell lines Interaction(miR-338-3p/SMAD5 axis) In Vivo Experiment//Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay Our data indicated that up-regulated circ_0008450 was correlated with NPC CDDP resistance. Mechanistically, circ_0008450 directly bound to miR-338-3p, and the regulatory effects of circ_0008450 on cell malignant behaviors and CDDP sensitivity were mediated by miR-338-3p in vitro. SMAD5 was a direct target of miR-338-3p and circ_0008450 mediated SMAD5 expression through miR-338-3p. Furthermore, the enforced level of miR-338-3p regulated cell malignant behaviors and CDDP sensitivity in vitro via down-regulating SMAD5. Yes Moreover, the knockdown of circ_0008450 suppressed cell proliferation, migration, invasion, and promoted apoptosis and CDDP sensitivity in vitro, as well as weakened tumor growth in vivo. 34387609 NEAT1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells regulation[miR-410-3p/ CCND1 axis] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay NEAT1 and CCND1 were upregulated, while miR-410-3p was down-regulated in breast cancer tissues and cells. NEAT1 induced breast cancer progression by regulating the miR-410-3p/CCND1 axis, indicating that NEAT1 may be a potential therapeutic target in breast cancer. Higher NEAT1 expression level was associated with lower survival rate of breast cancer patients. Yes Knockdown of miR-410-3p restored silenced NEAT1-mediated the inhibition of on proliferation, migration, invasion and EMT of breast cancer cells. 32675392 NORAD LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and clls Interaction(miR-211-5p/FOXD1/VEGF-A axis) qRT-PCR Increased lncRNA NORAD and decreased miR-211-5p expression were first detected in HCC compared with the peritumorial area. Mechanistically, we found that NORAD functions as a sponge for miR-211-5p. Moreover, it was revealed that decreased miR-211-5p induced the expression of FOXD1 as well as its downstream target VEGF-A, thereby contributes to enhanced angiogenesis of HCC. Yes Further studies showed that knockdown of NORAD or overexpression of miR-211-5p impaired the proliferation, migration and angiogenesis of HCC cells. 33309645 NORAD LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues and cells regulation[miR-422a] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay The results indicated that NORAD expression was significantly increased in lung cancer tissues and cells compared with adjacent healthy tissues and cells.The present study suggested that NORAD regulated lung cancer cell EMT by regulating the expression of miR‑422a, providing a potential therapeutic target for the intervention of the development of NSCLC. Yes Compared with the control groups, NORAD overexpression promoted SK?MES?1 cell viability, migration and invasion, whereas NORAD knockdown resulted in the opposite effects in A549 cells. 33300080 NEAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(miR-128-3p/ADAM28 axis) In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//FISH//CCK8//qRT-PCR//Luciferase Report Assay//IHC//IF We showed NEAT1 and ADAM28 expression levels were upregulated, while the miR-128-3p level was downregulated in NSCLC tissues and cells. NSCLC patients with high NEAT1 expression levels, low miR-128-3p levels, or high ADAM28 levels had significantly reduced overall survival times. Silencing of NEAT1 inhibited NSCLC cell autophagy and promoted apoptosis by sponging miR-128-3p. MiR-128-3p directly targeted ADAM28 and suppressed ADAM28 expression, which led to deactivation of the JAK2/STAT3 signaling pathway. Furthermore, ADAM28 overexpression attenuated miR-128-3p overexpression-induced apoptosis and autophagy inhibition in NSCLC by increasing the phosphorylation of JAK2 and STAT3. NEAT1 depletion or miR-128-3p overexpression inhibited autophagy and promoted apoptosis in vivo by suppressing ADAM28. In other word, silencing NEAT1 inhibited autophagy and then promoted NSCLC cell apoptosis by deactivating the JAK2/STAT3 signaling pathway through regulation of miR-128-3p/ADAM28 axis. Yes Silencing of NEAT1 inhibited NSCLC cell autophagy and promoted apoptosis by sponging miR-128-3p. MiR-128-3p directly targeted ADAM28 and suppressed ADAM28 expression, which led to deactivation of the JAK2/STAT3 signaling pathway. 36054559 MEG3 LncRNA Homo sapiens Laryngeal Neoplasms laryngeal cancer tissues Regulation[miR-23a/APAF-1 axis] qRT-PCR//Western Blot MEG3 was down-regulated in laryngeal cancer tissues, and the low MEG3 expression was associated with advanced clinical stage. Particularly, MEG3 bound to miR-23a specifically and a reciprocal negative regulation existed between miR-23a and MEG3. Moreover, MEG3 up-regulated apoptotic protease activating factor-1 (APAF-1), a known miR-23a's target, thereby leading to the activation of caspase-9 and caspase-3. Meanwhile, these activated effects were rescued by miR-23a overexpression. In conclusion, the present study demonstrated that MEG3 functions as a novel tumour suppressive LncRNA in laryngeal cancer for the first time. Furthermore, MEG3 may act as a ceRNA to regulate APAF-1 expression by competitive binding to miR-23a, thereby regulating the progression of laryngeal cancer. MEG3 was down-regulated in laryngeal cancer tissues, and the low MEG3 expression was associated with advanced clinical stage. Yes Additionally, MEG3 overexpression inhibited the proliferation and induced the apoptosis of laryngeal cancer cells in vitro and in vivo. 31328388 hsa_circ_0001801 CircRNA Homo sapiens Glioblastoma glioblastoma tissues Regulation[miR-628-5p/HMGB3 axis] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The up-regulation of circ-0001801 and HMGB3 and the down-regulation of miR-628-5p were both observed in GBM tumors and cells compared with the normal ones.In addition, we discovered that circ-0001801 was a sponge of miR-628-5p and HMGB3 was a target of miR-628-5p. Furthermore, miR-628-5p inhibitor abolished circ-0001801 silencing-mediated inhibition of cell progression in GBM. Similarly, HMGB3 restored circ-0001801 silencing-mediated repression on GBM cell progression. We also noticed that circ-0001801 could improve HMGB3 expression by sponging miR-628-5p in GBM. Yes Depletion of circ-0001801 reduced GBM cell proliferation, migration, invasion and EMT. 31858556 NORAD LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC stem cells Interaction(miR‑26a‑5p) Wound Healing Assay//Cell Viability Assay//Transwell Assay Collectively, the present study demonstrated that NORAD knockdown attenuated the migration, invasion and EMT of HNSCC stem cells via miR‑26a‑5p. Yes siNORAD inhibited cell vitality, migration and invasion, as well as promoted apoptosis, increased the expression of epithelial cell markers and decreased the expression of interstitial cell markers in HNSCC stem cells. miR‑26a‑5p was a downstream gene of NORAD, and knockdown of miR‑26a‑5p partially offset the regulatory effect of siNORAD on HNSCC stem cells. 34435652 NORAD LncRNA Homo sapiens Osteosarcoma OS samples Interaction(miR-155-5p) qRT-PCR//RIP//Transwell Assay NORAD was significantly increased in OS samples in comparison with controls, while miR-155-5p was reduced. There was a negative correlation between NORAD and miR-155-5p expression levels in OS samples. Taken together, the results of the present study indicated that the NORAD/miR-155-5p axis played a crucial role in regulating the proliferation, migration and invasion of OS cells. Yes Knockdown of NORAD and transfection of miR-155-5p mimics markedly inhibited the viability, migration and invasion of OS cells. 33968176 NORAD LncRNA Homo sapiens Osteosarcoma OS cell Interaction(miR-877-3p/CREBBP ) qRT-PCR//RIP BMSC-EVs promoted OS cell proliferation, invasion, migration, and angiogenesis. BMSC-EVs carried NORAD into OS cells and upregulated CREBBP by sponging miR-877-3p. miR-877-3p downregulation or CREBBP overexpression partly inverted the inhibitory effect of EVs by silencing NORAD on OS cell proliferation, invasion, migration, and angiogenesis. In vivo experiments validated that BMSC-EV-derived NORAD facilitated tumor growth by upregulating CREBBP via miR-877-3p. Yes miR-877-3p downregulation or CREBBP overexpression partly inverted the inhibitory effect of EVs by silencing NORAD on OS cell proliferation, invasion, migration, and angiogenesis. In vivo experiments validated that BMSC-EV-derived NORAD facilitated tumor growth by upregulating CREBBP via miR-877-3p. 35281474 Neat1 LncRNA Mus musculus Melanoma A-375 melanoma cells Regulation(M2 macrophage polarization) In Vivo Experiment//RIP//Luciferase Report Assay The results indicated that BMSC-EVs could be internalized by macrophages to promote the expression of macrophages M2 markers. M2 type macrophages promoted malignancy of melanoma cells. NEAT1 derived from BMSC-EVs promoted the progression of melanoma by promoting M2 polarization of macrophages. NEAT1 inhibits miR-374 expression, while miR-374 could upregulate LGR4-dependent IQGAP1 expression. The tumor-inhibiting effect of NEAT1 silencing was validated in the nude mouse xenograft model. Collectively, the results demonstrated that BMSC-EVs carrying NEAT1 can promote the progression of melanoma by inducing M2 polarization of macrophages, and thus may be considered as a potential target for melanoma therapeutics. Yes The tumor-inhibiting effect of NEAT1 silencing was validated in the nude mouse xenograft model. 35115683 Neat1 LncRNA Mus musculus Diabetic Nephropathies cell lines Expression[highly expressed] CCK8//qPCR//Western Blot MMCs (SV40 MES13 cells) were cultured under 30 mM glucose to construct DN cellular model (high glucose (HG) group); meanwhile, MMCs cultured under 5.6 mM glucose (normal glucose (NG) group) and 5.6 mM glucose plus 24.4 mM 3-O-methyl-D-glucose (osmotic control (OC) group) served as controls, and lnc-NEAT1 expression was determined by qPCR assay. Lnc-NEAT1 expression was elevated in HG group compared to NG group and OC group. Cell proliferation was decreased, and proliferative marker protein Cyclin D1 and proliferating cell nuclear antigen expressions also decreased in Sh-NEAT1 group compared to Sh-NC group. For cell apoptosis, apoptosis rate was increased, and apoptotic protein Cleaved Caspase3 expression enhanced but anti-apoptosis protein Bcl-2 expression decreased in Sh-NEAT1 group compared to Sh-NC group. For fibrosis markers (including fibronectin and collagen I) and inflammatory cytokines (including tumor necrosis factor-α, interleukin-1β and interleukin-6), their expressions were reduced in Sh-NEAT1 group compared to Sh-NC group. Lnc-NEAT1 is overexpressed, and its downregulation inhibits cell proliferation, fibrosis, and inflammation but promotes cell apoptosis in HG-induced MMCs DN cellular model. Yes Lnc-NEAT1 is overexpressed, and its downregulation inhibits cell proliferation, fibrosis, and inflammation but promotes cell apoptosis in HG-induced MMCs DN cellular model. 31933932 MEG3 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues,cell lines Regulation[miR-9-5p/QKI-5 axis] CCK8//qRT-PCR//Western Blot LncRNA MEG3 was a down-regulated lncRNA in prostate cancer tissues and cells and could inhibit the expression of miR-9-5p, whereas miR-9-5p down-regulated QKI-5 expression.On the contrary, miR-9-5p mimics presented an opposite tendency in prostate cancer cells. Furthermore, MEG3 inhibited tumour growth and up-regulated expression of QKI-5 in vivo. LncRNA MEG3 was a down-regulated lncRNA in prostate cancer and impacted the abilities of cell proliferation, migration and invasion, and cell apoptosis rate, this regulation relied on regulating miR-9-5p and its targeting gene QKI-5. Yes Overexpressed MEG3 and QKI-5 could decrease the abilities of proliferation, migration and invasion in prostate cancer cells effectively and increased the apoptosis rate. 30565858 MEG3 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//Transfection//Cell Apoptosis Assay Preliminary microarray data from a previous study indicated that lncRNA MEG3 expression was altered in plasma of patients with sepsis. The present study found that the plasma levels of lncRNA MEG3 were significantly higher in sepsis patients compared with healthy controls. Patients were subsequently divided into high and low lncRNA MEG3 expression groups according to the Youden's index. Patients from the high lncRNA MEG3 expression group exhibited a significantly higher mortality rate compared with those from the low lncRNA MEG3 expression group. According to treatment outcomes, patients were divided into survival and mortality groups. It was observed that the pre-therapy expression levels of lncRNA MEG3 were significantly higher in mortality group compared with the survival group. Yes Cell experiments in vitro revealed that lncRNA MEG3 overexpression and silencing using siRNA promoted and inhibited renal epithelial cell and cardiomyocyte apoptosis induced by lipopolysaccharide, respectively. 31641380 NEAT1 LncRNA Homo sapiens larynx squamous papilloma LP tissues and cells Interaction(miR-577 or miR-1224-5p/CCNT2 axis) Western Blot//Transfection//RIP//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay Lnc-NEAT1 was highly expressed in LP, and enhanced LP cell proliferation, and it was inhibited by Lnc-NEAT1 depleting. Concerning the underlying mechanism, it was found that Lnc-NEAT1 could functionally sponge microRNA-577 (miR-577) and microRNA-1224-5p (miR-1224-5p) and up-regulate Cyclin T2 (CCNT2) in LP cells. Notably, CCNT2 knockdown blocked Lnc-NEAT1-induced LP cell proliferation, and rescued cell apoptosis, which was specifically indicated by restoration of Bax, Cleaved caspase 3 and Cleaved caspase 9. Lnc-NEAT1 played a carcinogenic role in LP through mediating miR-577 or miR-1224-5p/CCNT2 axis, which may provide promising insights for the treatment of LP. Yes Lnc-NEAT1 was highly expressed in LP, and enhanced LP cell proliferation, and it was inhibited by Lnc-NEAT1 depleting. 35012431 MEG3 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cell lines Interaction[regulating miR-361-5p/TRAF3 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay We found that MEG3 was downregulated in CCA tissues and cell lines, especially in TFK1 and QBC939 cells. Our results suggested that MEG3 repressed cholangiocarcinoma by downregulating miR-361-5p expression. Meanwhile, the suppression of miR-361-5p might improve CCA survival by targeting TRAF3 and inhibiting the NF-κB pathway, which might help to develop new strategies for CCA therapy. Yes Further analysis indicated that MEG3-plasmid could inhibit cell viability and induce cell apoptosis in CCA cells, but these effects were significantly reversed by miR-361-5p mimic. 31539122 NORAD LncRNA Homo sapiens Esophageal Neoplasms EC cells regulation[MDM2/p53/Bcl2/Bax pathway] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Transwell Assay The results revealed that LINC00657 showed an aberrant high expression in EC cells, which promoted the growth of EC cells. LINC00657 knockdown inhibited CKS2 expression to suppress the proliferation, migration, and invasion of EC cells and induced apoptosis via regulating the MDM2/p53/Bcl2/Bax pathway. Yes LINC00657 knockdown inhibited CKS2 expression to suppress the proliferation, migration, and invasion of EC cells and induced apoptosis via regulating the MDM2/p53/Bcl2/Bax pathway. 32426838 NORAD LncRNA Homo sapiens Glioma cell lines regulation[AKR1B1 ] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Colony Formation Assay//Transwell Assay The results revealed that NORAD and AKR1B1 were highly expressed in glioma cells. These findings demonstrated that NORAD silencing suppressed proliferation, invasion, and migration and boosted apoptosis of glioma cells via downregulating the AKR1B1 expression, which may provide a potential therapeutic target for glioma treatment. Yes NORAD silencing inhibited proliferation, invasion and migration but promoted apoptosis of glioma cells, accompanied by the expression changes of migration- and apoptosis-related proteins. 32778640 NORAD LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines Interaction(microRNA-202-5p) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//RIP//qRT-PCR//MTT//Luciferase Report Assay LncRNA NORAD and ANP32E were upregulated in PC tissues and cells, whereas the miR-202-5p level was down-regulated. LncRNA NORAD competitively bound to miR-202-5p, and promoted the expression of the miR-202-5p target gene ANP32E thereby promoting PC cell viability, proliferation, and self-renewal ability in vitro, as well as facilitating tumorigenesis of PCSCs in vivo. Yes  NORAD overexpression increased the proportion of ALDH high-activity cells, accelerated proliferation, reduced apoptosis, colony, and sphere formation, and G0/G1 phase-arrested cells, increased S phase-arrested cells, and elevated the ratios of cleaved-caspase3 to pro-caspase3 and that of cleaved-caspase9 to pro-caspase9, but downregulated protein expression of PARP1, and upregulated the expression of Oct4, Nanog, and Sox2. To summarize, NORAD induced the viability, proliferation, and self-renewal while suppressing apoptosis of PCSCs through inhibiting miR-202-5p expression. 34551785 MEG3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC PC9 and H1299 cells Interaction(miR‑21‑5p/PTEN axis) Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay Reverse transcription‑quantitative (RT‑q)PCR analysis showed that MEG3 was downregulated in NSCLC PC9 and H1299 cells. Additionally, bioinformatics analysis indicated that MEG3 sponges microRNA (miR)‑21‑5p; miR‑21‑5p was predicted to target the phosphatase and tensin homolog (PTEN) 3'‑untranslated region sequence. MEG3 overexpression led to miR‑21‑5p suppression and PTEN upregulation in PC9 and H1299 cells, as detected by RT‑qPCR. Subsequently, western blot analysis confirmed that MEG3 overexpression enhanced PTEN expression levels and inhibited the PI3K/AKT signaling pathway in NSCLC cells. Yes Furthermore, Transwell assay demonstrated that MEG3 overexpression had an inhibitory effect on cell migration and invasion. MEG3 overexpression also mediated epithelial?to?mesenchymal transition by significantly enhancing E?cadherin and decreasing N?cadherin, Vimentin and matrix metalloprotein 9 expression levels in NSCLC cells, as indicated by western blot analysis. 33495842 NEAT1 LncRNA Homo sapiens Esophageal Neoplasms metastatic tissues Interaction(miR-377/E2F3 axis) Bioinformatics Analysis The expression of NEAT1 was also upregulated in metastatic tissues compared to nonmetastatic. At the molecular level, the regulatory effects of lncRNA NEAT1 were shown to be modulated by the miR-377/E2F3 signaling axis. Yes The elimination of lncRNA NEAT1 led to a significant decrease (P<0.05) decrease in the viabilities of cancer cells due to the induction of apoptosis. Cancer cell migration and invasion were also significantly reduced (P<0.05) upon lncRNA NEAT1. 36252156 MEG3 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cells Interaction[modulating Bmi1/RNF2] qRT-PCR In this study, MEG3 expression was significantly downregulated in both CCA tissues and cells in comparison with that in nontumor controls, respectively.Enhanced MEG3 also suppressed migration and invasion of CCLP-1 and QBC939 cells by reversing epithelial-mesenchymal transition (EMT) process. On the contrary, the proliferation, metastasis, and EMT were facilitated via knocking down MEG3. In addition, the expression of B lymphoma Mo-MLV insertion region 1 (Bmi1) and RING finger protein 2 was impacted by gain or loss of MEG3, furthermore, the malignant processes induced by MEG3 knockdown were rescued by means of silencing Bmi1. These data suggested that MEG3 caused tumor suppressive effects partly through mediating polycomb repressive complex 1. Our findings elucidate that MEG3 exerts critical functions in CCA development and likely acts as a promising tumor indicator or intervention target for CCA. In this study, MEG3 expression was significantly downregulated in both CCA tissues and cells in comparison with that in nontumor controls, respectively, and this downexpression was prominently associated with advanced TNM stage, lymph node invasion, and poor survival. Yes Functionally, MEG3 overexpression inhibited CCA growth in vitro and in vivo. 31119760 MEG3 LncRNA Homo sapiens Gallbladder Neoplasms cell lines regulation[NF-κB signaling pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay The expression of lncRNA MEG3 in three kinds of GBC cell lines was lower than that in human immortalized normal biliary epithelial cells (p<0.05). LncRNA MEG3 activates the NF-κB signal in GBC cells to affect the proliferation and apoptosis of GBC cells. Yes The results of CCK-8 assay and colony formation assay showed that overexpression of lncRNA MEG3 significantly reduced the proliferation rate and colony formation ability of GBC-SD cells compared with negative control (NC) group (p<0.05, p<0.05). 32633352 MIAT LncRNA Homo sapiens Diabetic Nephropathies kidney tissues regulation[E2F3 ] Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining Up-regulation of MIAT was observed in DN. In summary, our data explored the underlying mechanism of DN pathogenesis validated that MIAT induced mesangial cell proliferation and fibrosis via sponging miR-147a and regulating E2F3. Yes Then, functional assays displayed that silence of MIAT by siRNA significantly repressed the proliferation and cycle progression in mesangial cells induced by HG. 33009725 NORAD LncRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines Interaction(miR-520h/CKS1B axis) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//MTT//Cell Proliferation Assay//Bioinformatics Analysis//Transwell Assay The expression levels of LINC00657 and CKS1B were enhanced and miR-520h expression level was reduced in PC tissues and cell lines compared with adjacent normal tissues or HPDE6 cells. In conclusion, the results of the present study demonstrated that LINC00657 knockdown repressed the viability, migration and invasion of PC cells via targeting the miR-520h/CKS1B axis, which may offer a future target for PC therapy. Yes LINC00657 knockdown decreased the viability, migration and invasion of PC cells. 34504588 MEG3 LncRNA Homo sapiens Gallbladder Neoplasms GBC tissues and cells interaction[EZH2 ,LATS2] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Colony Formation Assay//ChIP We found that MEG3 was downregulated in GBC tissues and cells, and low expression of MEG3 was correlated with poor prognostic outcomes in patients.Furthermore, MEG3 executed its functions via EZH2 to regulate the downstream target gene LATS2. We found that MEG3 was downregulated in GBC tissues and cells, and low expression of MEG3 was correlated with poor prognostic outcomes in patients. Yes Overexpression of MEG3 inhibited GBC cell proliferation and invasion, induced cell apoptosis and decreased tumorigenicity in nude mice. 30282996 hsa_circ_0000345 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC cells Interaction(miR-513a-3p/PTEN axis) Transfection//Invasion Assay//Migration Assay Compared with NP69 cells, hsa_circ_0000345 was down-regulated in NPC cells. Furthermore, hsa_circ_0000345 promoted PTEN expression by sponging miR-513a-3p. Both miR-513a-3p overexpression and PTEN knockdown promoted cell proliferation, migration and invasion of SUNE1 cells, which were effectively abolished by hsa_circ_0000345 up-regulation. Yes hsa_circ_0000345 overexpression repressed cell proliferation, migration and invasion of SUNE1 cells, whereas hsa_circ_0000345 knockdown promoted cell proliferation, migration and invasion of 6-10B cells. 35545766 hsa_circ_0001946 CircRNA Homo sapiens Glioblastoma cell lines Interaction[modulating miR-671-5p and CDR1] Western Blot//Flow Cytometry//qRT-PCR//Colony Formation Assay//Transwell Assay The expression of circ_0001946 and CDR1 was low and that of miR-671-5p was high in GBM cells. Circ_0001946 suppressed the expression of miR-671-5p, thus upregulating the expression of CDR1, the gene downstream of miR-671-5p. Yes Circ_0001946 and CDR1 reduced proliferation, migration, and invasion and increased apoptosis in GBM cells, whereas miR-671-5p had an opposite effect. The xenograft mouse model and immunohistochemistry results indicated that circ_0001946 inhibited GBM growth as well as the expression of Ki67 in GBM cells. 30663767 circARID1A CircRNA Homo sapiens Glioblastoma GBM tissues and cell lines Interaction(miR-370-3p/ TGFBR2 pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//Luciferase Report Assay//Microarray//Transwell Assay By circRNA array analysis we found that circARID1A was significantly up-regulated in GBM. Next, we found that circARID1A was up-regulated in GBM tissues and cell lines. By performing dual-luciferase reporter assays, RNA pull-down and fluorescent in situ hybridization (FISH), we determined that circARID1A directly bound to miR-370-3p. Moreover, we confirmed that transforming growth factor beta receptor 2 (TGFBR2) was the target gene of miR-370-3p by performing RNA pull-down, dual-luciferase reporter assays and western blotting. Further experiments verified that circARID1A promoted GBM cell migration and invasion by modulating miR-370-3p/ TGFBR2 pathway. Yes Interfering with circARID1A inhibited the migration and invasion of a human GBM cell line U87. In addition, we demonstrated that silencing circARID1A restrain the growth of GBM in vivo. 35982888 hsa_circ_0092367 CircRNA Homo sapiens Pancreatic Neoplasms PC tissues and cell lines Interaction(miR-1206/ESRP1 Axis) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay We demonstrated that circ_0092367 was significantly downregulated in PC tissues and cell lines, and a high expression of circ_0092367 was associated with improved survival in patients with PC. Cytoplasmic circ_0092367 could directly repress the levels of miR-1206 and thus upregulate the expression of ESRP1, thereby inhibiting EMT and enhancing the sensitivity of PC cells to gemcitabine treatment. We demonstrated that circ_0092367 was significantly downregulated in PC tissues and cell lines, and a high expression of circ_0092367 was associated with improved survival in patients with PC. Yes Gain- and loss-of-function assays revealed that circ_0092367 inhibited epithelial-mesenchymal transition (EMT) phenotypes and sensitized PC cells to gemcitabine treatment in vitro and in vivo. 34828307 MEG3 LncRNA Homo sapiens Glioblastoma U251 cells Regulation(HIF1α) Invasion Assay//Transwell Assay The expression of MEG3 was significantly lower and HIF1α mRNA and protein expressions were significantly higher in U251 cells than in HFGCs (P < 0.05).In U251 cells, overexpression of MEG3 significantly decreased the mRNA and protein expressions of HIF1α(P < 0.05).Hypoxic exposure for 12h also resulted in significantly lowered expression of HIF1α protein in U251 cells (P < 0.05). Yes Overexpression of MEG3 obviously suppressed the proliferation and invasiveness of U251 cells (P < 0.05). 33509767 circCRIM1 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC cells Interaction(miR-34c-5p/FOSL1 axis) Western Blot//Transfection//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay CircCRIM1 and FOSL1 were upregulated in NPC cells, while miR-34c-5p was downregulated. The miR-34c-5p inhibitor notably promoted the malignant behaviour of NPC cells, while miR-34c-5p mimics exerted the opposite effect. Moreover, circCRIM1 could bind with miR-34c-5p, and FOSL1 was identified to be downstream of miR-34c-5p. Yes Knockdown of circCRIM1 significantly decreased the invasion, viability and migration of NPC cells. Furthermore, circCRIM1 downregulation notably inhibited the proliferation and invasion of NPC cells, while this phenomenon was significantly reversed by FOSL1 overexpression. 35484574 hsa_circ_0028007 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction(miR-656-3p/ELF2 Axis) In Vivo Experiment//Western Blot//Transfection//Tube Formation Assay//Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay Compared to normal tissues and cells, circ_0028007 level was elevated in NPC tissues and cells. circ_0028007 silencing could regulate the AMP-activated protein kinase/mammalian target of rapamycin pathway in NPC cells. Circ_0028007 promoted the malignant behaviors of NPC cells via acting as miR-656-3p sponge. In addition, ELF2 was demonstrated to be the target gene of miR-656-3p. MiR-656-3p overexpression restrained NPC cell malignant phenotypes, while ELF2 elevation reversed the effects. Circ_0028007 contributed to the progression of NPC by decoying miR-656-3p and elevating ELF2. Yes Knockdown of circ_0028007 repressed NPC cell growth, migration, invasion, and angiogenesis, facilitated apoptosis in vitro and blocked tumor growth in vivo. 35239093 NORAD LncRNA Homo sapiens Prostatic Neoplasms cell lines Expression[highly expressed] CCK8//qRT-PCR//Migration Assay To study the effect of NORAD on PCA, we first detected NORAD levels by qRT-PCR in PCA cells. NORAD expression was significantly higher in the four human PCA cell lines than in control cells (Figure 1; P < 0.05). The highest expression of NORAD was detected in PC-3 and DU-145 cells (P < 0.01), so these were used in subsequent experiments. Yes Cell proliferation and migration rates were significantly lower in the siNORAD group than in the wild-type group, while the apoptosis level was significantly higher in the siNORAD group compared with the wild-type group. 31342822 hsa_circ_0039908 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cells Interaction(miR-let-7c/RRM2 axis) Western Blot//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay Finally, circRNA_0039908/let7c-5p/RRM2 axis was identified in our research, it can play an important role in the LUAD pathogenesis progression and we found that the proliferation, invasion and migration abilities of LUAD cells can be suppressed after knockdown of circRNA_0039908. Yes Finally, circRNA_0039908/let7c-5p/RRM2 axis was identified in our research, it can play an important role in the LUAD pathogenesis progression and we found that the proliferation, invasion and migration abilities of LUAD cells can be suppressed after knockdown of circRNA_0039908. 36046641 MEG3 LncRNA Homo sapiens Melanoma cancer stem cell Interaction(miR-208/SOX4) Cell Proliferation Assay//qRT-PCR//Colony Formation Assay//In Vivo Experiment Luciferase reporter assays identified miR-208 and SOX4 as downstream targets of lncRNA MEG3. Overexpression of miR-208 and silencing of SOX4 rescued invasion and proliferation by cells that overexpressed lncRNA MEG3. Moreover, lncRNA MEG3 inhibited cancer stem cell differentiation and suppressed melanoma progression and metastasis through inhibition of miR-208 by SOX4. Yes Melanoma cell lines were found to be sensitive to lncRNA MEG3 expression levels and overexpression was found to inhibit melanoma cell proliferation and invasion, both in vitro and in vivo. 35838912 hsa_circ_0029426 CircRNA Homo sapiens Glioblastoma GBM tissue Interaction[sponging miR-197] qRT-PCR//Luciferase Report Assay//Microarray In the previous study, elevated circ_0029426 was first observed in glioblastoma (GBM) tissues compared with normal tissues by circRNA microarray. Mechanistically, miR-197 was predicted and verified to be sponged by circ_0029426. More importantly, the oncogenic functions of circ_0029426 are partially attributed to its sExpression[Expression[up-expression]-expression]pression on miR-197. Collectively, circ_0029426 may be taken as a potential therapeutic target for GBM. As a result, the circ_0029426 expression is tightly correlated with patients' clinical severity and prognosis. Yes Functionally, circ_0029426 strikingly promoted cell proliferation, migration and invasion, and inhibited cell apoptosis. 30548670 circMMP9 CircRNA Homo sapiens Glioblastoma GBM tissues interaction[miR-124] qRT-PCR//Luciferase Report Assay//FISH In this study, we screened differentially expressed circRNAs and identified circMMP9 in GBM.Our findings indicate that eIF4A3-induced circMMP9 is an important underlying mechanism in GBM cell proliferation, invasion and metastasis through modulation of the miR-124 signaling pathway, which could provide pivotal potential therapeutic targets for the treatment of GBM. Yes We found that circMMP9 acted as an oncogene, was upregulated in GBM and promoted the proliferation, migration and invasion abilities of GBM cells. 30470262 Neat1 LncRNA Mus musculus Breast Neoplasms cell line Interaction(PGK1/PGAM1/ENO1 complexes ) Co-IP//CCK8//qRT-PCR//RIP//FISH//Cell Cycle Assay//IHC//Invasion Assay Notably, NEAT1 is upregulated in cancer patients and correlates with high levels of these complexes, and genetic and pharmacological blockade of penultimate glycolysis ablates NEAT1-dependent tumorigenesis. Yes Here, we show that the deletion of the long noncoding RNA (lncRNA) Neat1 in MMTV-PyVT mice profoundly impairs tumor initiation, growth, and metastasis, specifically switching off the penultimate step of glycolysis. 34879239 hsa_circ_6783 CircRNA Homo sapiens Adenocarcinoma of Lung LA cell lines and PWB Expression(highly expressed) Cell Proliferation Assay//qRT-PCR//Transfection//Cell Apoptosis Assay The expression levels of circRNA6783 were significantly higher in LA cell lines and PWB (P < 0.05). Yes In addition, functional experiments showed that overexpression of circRNA6783 restrained cell proliferation, significantly increased spontaneous apoptosis. 35345604 hsa_circ_0001998 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues and cell lines Interaction(miR-145) Transfection//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ_0001998 was upregulated in LUAD, and silencing circ_0001998 suppressed viability, proliferation, and invasion of LUAD cells. The target gene of circ_0001998, miR-145, was downregulated in LUAD, and the low expression of miR-145 indicated a poor prognosis. Yes Circ_0001998 was upregulated in LUAD, and silencing circ_0001998 suppressed viability, proliferation, and invasion of LUAD cells. 35600959 hsa_circ_0129047 CircRNA Homo sapiens Adenocarcinoma of Lung LAC cells and tissues Interaction(miR-1206/BMPR2 ) RNA Pull-Down//cell invasion assay//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay Circ_0129047 expression levels were reduced in LAC cells and tissues. Mechanistically, we discovered that circ_0129047 could sponge miR-1206, and miR-1206 could directly target BMPR2. In conclusion, circ _0129047 was found to play a tumor suppressive role in LAC progression; it upregulated BMPR2 expression to inhibit LAC progression by sponging miR-1206. Yes In addition, circ_0129047 or BMPR2 knockdown facilitated the viability, proliferation, adhesion, migration, and invasion, while inhibiting the apoptosis of LAC cells. 35570745 NORAD LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines interaction[sponging miR-424 to regulate PD-L1 expression] CCK8//qRT-PCR//Flow Cytometry//Western Blot LINC00657 was remarkably overexpressed in HCC tissues and cell lines, associated with poor prognosis. LINC00657 was remarkably overexpressed in HCC tissues and cell lines, associated with poor prognosis. Yes LINC00657 knockdown repressed cell proliferation and invasion, promoted cell apoptosis of HCC cell lines. 32996041 MEG3 LncRNA Homo sapiens ovarian carcinoma tumors and adjacent healthy tissues Interaction[lncRNA AGAP2-AS1 ] qRT-PCR Compared with adjacent healthy tissues, AGAP2-AS1 was significantly upregulated in tumor tissues.lncRNA AGAP2-AS1 is upregulated in ovarian carcinoma and negatively regulates lncRNA MEG3 to participate in the regulation of cancer cell proliferation. Yes In addition, MEG3 overexpression attenuated the effects of AGAP2-AS1 overexpression on cancer cell proliferation, but AGAP2-AS1 overexpression did not obviously affect cancer cell invasion and migration. 31233485 NORAD LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-144-3p/SEPT2] qRT-PCR//Colony Formation Assay We showed NORAD expression was elevated in both HCC tissues and cells. Collectively, we showed NORAD serves as an oncogenic lncRNA to promote HCC progression via the miR-144-3p/SEPT2 axis. Yes We showed NORAD expression was elevated in both HCC tissues and cells. NORAD knockdown inhibits HCC cell growth but promotes apoptosis, while the overexpression of NORAD has opposite effects. 32509217 MEG3 LncRNA Homo sapiens Carcinoma, Renal Cell CCRCC and adjacent tissue Regulation[miR-7/RASL11B signaling] Wound Healing Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay Decreased MEG3 expression was observed in CCRCC tissues and cells. MEG3 could up-regulate RASL11B to inhibit the cell proliferation, invasion, and migration; induce G0/G1 cell cycle arrest; and promote cell apoptosis by suppressing miR-7 in CCRCC. Yes Overexpression of MEG3 accelerated apoptosis; inhibited cell proliferation, migration and invasion; and induced G0/G1 phase cell cycle arrest in CCRCC. 29968912 Neat1 LncRNA Mus musculus Parkinson Disease brain tissue regulation[miR-124/KLF4 axis] qRT-PCR//MTT//Luciferase Report Assay//Western Blot The number of TH+ cells was reduced, and the expression levels of NEAT1 and Krüppel-like factor 4 (KLF4) were increased in the midbrain of MPTP-HCl-treated mice.NEAT1 knockdown increased cell viability and suppressed apoptosis in PD via regulating the miR-124/KLF4 axis, providing a promising avenue for the treatment of PD. Yes Knockdown of NEAT1 promoted cell viability and decreased apoptosis in MPP-treated SH-SY5Y cells, which could be reversed by upregulating KLF4. 33817255 MEG3 LncRNA Homo sapiens Retinoblastoma RB cells Regulation( PI3K /Akt/mTOR signaling pathway) In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//Cell Proliferation Assay MEG3 mRNA level was significantly lower in RB cells than in non-cancer cells (p < 0.01). After overexpressing MEG3, p-PI3K, p-Akt and p-mTOR levels were significantly downregulated (p < 0.01). Our data suggest that MEG3 increases apoptosis and reduces tumorigenicity of RB cells through inactivating the PI3K/Akt/mTOR pathway. Yes Overexpressing MEG3 resulted in significant reduction in cell proliferation (p < 0.05), migration (p < 0.01) and significant increase in apoptosis (p < 0.01). Furthermore, in the xenograft model, RB cells overexpressing MEG3 generated significantly smaller tumors as compared to RB cells that did not overexpress MEG3 (p < 0.05). 36476400 Neat1 LncRNA Mus musculus Parkinson Disease brain tissue,cell line regulation[miR-212-3p/AXIN1 pathway] Western Blot//CCK8//qRT-PCR//RIP//ELISA NEAT1 was upregulated in PD mouse models and cell models. Our results demonstrated that NEAT1 knockdown suppressed PD progression through regulating the miR-212-3p/AXIN1 pathway, indicating that NEAT1 might be a therapeutic target for neuroprotection in PD. ++ Yes Function experiments confirmed that NEAT1 knockdown could promote the viability, suppress the apoptosis and inflammation of MPP-stimulated SK-N-SH cells to restrain PD progression. 33241432 Neat1 LncRNA Mus musculus Parkinson Disease MPTP-induced PD mice Interaction(miR-374c-5p) RNA Pull-Down//Western Blot//Tunel//qRT-PCR//Luciferase Report Assay//Cell Viability Assay The results demonstrated that the level of NEAT1 was upregulated in the MPTP-induced PD mice, dopamine neurons, and the SH-SY5Y cells treated with MPP+, whereas the level of miR-374c-5p was downregulated. As a possible target of NEAT1, miR-374c-5p could impact on the apoptosis and autophagy of the SH-SY5Y cells. NEAT1 inhibition upregulated the expression of miR-374c-5p, enhanced SH-SY5Y cell viability, and repressed autophagy and apoptosis in MPTP-induced PD mice. These findings indicated a potential therapeutic role of NEAT1 in treating PD. Yes NEAT1 level was positively correlated with MPP+ in a concentration-dependent manner. NEAT1 inhibition efficiently facilitated cell proliferation but inhibited apoptosis and autophagy in the MPP+-treated SH-SY5Y cells. Additionally, silencing of NEAT1 increased the TH+ rate of neurons and suppressed autophagy greatly in PD mice. 33984130 hsa_circ_0001058 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma cells and tissue specimen Interaction(miR-486-5p/TEK signaling axis) In Vivo Experiment//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Decreased circ_0001058 expression was observed in lung adenocarcinoma cells and tissue specimens. Circ_0001058 directly targeted miR-486-5p and depleted its expression. Restoring miR-486-5p could invert the inhibitory effects of circ_0001058 in the cancer cell phenotypes. Furthermore, miR-486-5p targeted TEK, so the inhibitory effects of TEK overexpression on the malignant behaviors of A549 and PC9 cells could also be abolished by miR-486-5p restoration. Yes Circ_0001058 overexpression restrained A549 and PC9 cells' abilities to proliferate, survive and invade, and it also repressed tumorigenesis in the animal models. 35946541 NORAD LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues regulation[miR-199a-3p] Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay LncRNA NORAD was highly expressed and miR-199a-3p was lowly expressed in ovarian cancer, and the expression levels of LNCRNARAD and miR-199a-3p were negatively correlated. LncRNA NORAD was highly expressed in ovarian cancer tissues, while silencing lncRNA NORAD expression could inhibit the proliferation, invasion, migration, and EMT of ovarian cancer cells by regulating miR-199a-3p, which might be a new target for the diagnosis and treatment of ovarian cancer. Yes Cell experiments showed that inhibiting the expression of lncRNA NORAD or up-regulating the expression of miR-199a-3p could inhibit the proliferation, invasion, migration, and EMT of ovarian cancer cells, while up-regulating the expression of lncRNA NORAD or inhibiting the expression of miR-199a-3p could promote their proliferation, invasion, migration, and EMT. 32141533 NORAD LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissue regulation[microRNA-150] CCK8//qRT-PCR//Luciferase Report Assay qRT-PCR showed that LINC00657 expression in OSCC tissue specimens was increased in comparison to normal ones. Additionally, it may accelerate the malignant progression of OSCC via regulating microRNA-150. Patients with high LINC00657 expression had higher pathological staging and lower overall survival. Yes Besides, the cell proliferation ability of the LINC00657 silencing group was remarkably decreased, while the opposite result was observed in LINC00657 overexpression group. 32196599 MIAT LncRNA Homo sapiens Neuroblastoma NBL cell lines (KELLY, IMR-32, SH-SY5Y, SK-N-AS, and SK-N-F1) Interaction(MIAT/NMYC Axis) Western Blot//Transfection//qRT-PCR//Cell Proliferation Assay//Cell Cycle Assay MIAT Expression Is Upregulated in Neuroblastoma Cell Lines and Tissues. Yes MIAT silencing induces cell death only in cells with NMYC amplification, but in NBL cells without NMYC amplification it decreases only the proliferation. MIAT downregulation markedly reduces the NMYC expression in NMYC-amplified NBL cell lines and c-Myc expression in NMYC non-amplified NBL cell lines, but the ectopic overexpression or downregulation of NMYC did not affect the expression of MIAT. 33806217 MEG3 LncRNA Homo sapiens Colorectal Neoplasms CC tumor tissues and cells Interaction(MEG3/miR-103a-3p/PDHB ceRNA pathway) In Vivo Experiment//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//Transwell Assay Expression of MEG3 was downregulated in human CC tumor tissues and cells (SW620 and HCT116), accompanied by higher miR-103a-3p and lower PDHB. Molecularly, miR-103a-3p was a target of MEG3, and further targeted PDHB. Similarly, in function, blocking miR-103a-3p suppressed CC in vitro by affecting proliferation, invasion, and ER stress; in addition, restoring miR-103a-3p partially counteracted the suppressive role of MEG3 in CC cells. Yes Restoring MEG3 suppressed cell viability, colony formation ability, and invasion, arrested cell cycle, and induced apoptosis rate in SW620 and HCT116 cells, as well as promoted expression of ER stress-related proteins (GRP78, ATF6, CHOP, caspase-3, and caspase-9). Furthermore, MEG3 overexpression hindered tumor growth and facilitated ER stress in vivo. 33118833 NORAD LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[targeting miR-202-5p] qRT-PCR We found that HCC tissues had a high level of NORAD compared with the paratumor tissues, and NORAD upregulation was associated with the shorter overall survival of patients with HCC. We address that NORAD has a tumor-promoting effect in HCC and describes a novel mechanism whereby NORAD regulates the TGF-β pathway as a ceRNA of Homo sapiens (hsa)-miR-202-5p. We found that HCC tissues had a high level of NORAD compared with the paratumor tissues, and NORAD upregulation was associated with the shorter overall survival of patients with HCC. Yes Furthermore, NORAD overexpression was demonstrated to promote HCC cell migration and invasion. 30537113 NORAD LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissus, cell lines Interaction[miR-155-5p] qRT-PCR We found that NORAD was substantially upregulated in both EOC cell lines and human tumors. Also, hsa-miR-155-5p was confirmed to be the competing target of NORAD in EOC, and its knockdown in OVCAR-3 and ES-2 cells reversed the NORAD downregulation-induced anticancer functions.z Yes In OVCAR-3 and ES-2 cells, lentivirus-mediated NORAD downregulation had significant anticancer effects, as it suppressed cell proliferation, decreased bufalin chemoresistance, arrested cell-cycle transition, and inhibited xenograft growth. 31250987 MEG3 LncRNA Homo sapiens Retinoblastoma retinoblastoma tissues Interaction(β-catenin ) RNA Pull-Down//Western Blot//Wound Healing Assay//Co-IP//qRT-PCR//RIP//migration assay//Transwell Assay The GEO database showed that the expression of MEG3 was low in retinoblastoma tissues and was closely associated with the invasion of retinoblastoma cells and activity of the Wnt pathway. Cell experiments confirmed that MEG3 could promote the binding of β-catenin and GSK-3β and induce phosphorylation, ubiquitination and degradation of β-catenin indirectly. Yes Both in vivo and in vitro experiments confirmed that MEG3 inhibited the migration and invasion of retinoblastoma cells. 35968358 NORAD LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cells Interaction(miR-577 and TPM4 ) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH LncRNA NORAD was highly expressed in OSCC tissues and cells.MiR-577 was found in OSCC with low expression, and RIP assays illustrated that NORAD, miR-577 and TPM4 coexisted in RNA-induced silencing complexes. Rescue assays proved that the overexpression of TPM4 could recover the effect of NORAD silencing on OSCC progression. Yes NORAD silencing repressed the biological behaviors of OSCC cells. 34991683 circLRFN5 CircRNA Homo sapiens Glioblastoma GBM tissues and cells Interaction(PRRX2/GCH1 ) qRT-PCR//Transfection//EdU Staining//Western Blot We found a novel circRNA circLRFN5 is downregulated in GBM and associated with GBM patients’ poor prognosis.Mechanistically, circLRFN5 binds to PRRX2 protein and promotes its degradation via a ubiquitin-mediated proteasomal pathway. PRRX2 can transcriptionally upregulate GCH1 expression in GSCs, which is a ferroptosis suppressor via generating the antioxidant tetrahydrobiopterin (BH4). We found a novel circRNA circLRFN5 is downregulated in GBM and associated with GBM patients’ poor prognosis. Yes CircLRFN5 overexpression inhibits the cell viabilities, proliferation, neurospheres formation, stemness and tumorigenesis of GSCs via inducing ferroptosis. 36266731 circFBXW7 CircRNA Homo sapiens Adenocarcinoma of Lung A549 and HCC2279 cell lines. Interaction(miR-942-5p) In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//FISH//RIP//MTT//migration assay//Luciferase Report Assay//EdU Staining circFBXW7 was downregulated in LUAD cell lines and tissues, and LUAD patients with lower levels had shorter DFS and OS. The in vitro study showed that circFBXW7 overexpression inhibited proliferation and migration of A549 and HCC2279 cell lines. Finally, we determined that circFBXW7 target miRNA-942-5p which regulates the EMT gene BARX2. The modulation of circFBXW7 levels produced significant changes in EMT genes in vitro and in vivo. circFBXW7 was downregulated in LUAD cell lines and tissues, and LUAD patients with lower levels had shorter DFS and OS. Yes These results were confirmed by circFBXW7 knockdown, which showed the reverse effect. The in vivo model showed that the circRNA levels influenced the tumor growth. 33889522 Neat1 LncRNA Mus musculus Lupus Erythematosus, Systemic myeloid-derived suppressor cells Regulation[ NEAT1-BAFF axis] Flow Cytometry//qRT-PCR//Immunoblotting//IF Mechanistically, we identified that the long non-coding RNA NEAT1 was over-expressed in G-MDSCs from MRL/lpr mice and could induce the promotion of G-MDSCs on IFN-I signaling activation of B cells through B cell-activating factor (BAFF) secretion. In addition, there was a positive correlation between NEAT1 and BAFF with the IFN signature in SLE patients. In conclusion, G-MDSCs may contribute to the IFN signature in SLE B cells through the NEAT1-BAFF axis, highlighting G-MDSCs as a potential therapeutic target to treat SLE. Yes Importantly, NEAT1 deficiency significantly attenuated the lupus symptoms in pristane-induced lupus mice. 31513833 MIAT LncRNA Homo sapiens Diabetic Nephropathies HK-2 Interaction(miR-182-5p/GPRC5A axis) RNA Pull-Down//Western Blot//Transfection//CCK8//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//ELISA//Colony Formation Assay HG induced the inhibition of cell growth, but accelerated apoptosis and inflammation as well as the activation of nuclear factor kappa B (NF-κB) pathway. MIAT reestablishment prevented the HG-induced cell damages and NF-κB signal activation. Mechanistically, MIAT was proved as a miR-182-5p sponge and regulated the expression of GPRC5A that was a miR-182-5p target. The rescued experiments demonstrated that MIAT downregulation or miR-182-5p upregulation aggravated the HG-induced cell damages and activated the NF-κB pathway via the respective regulation of miR-182-5p or GPRC5A. Yes Mechanistically, MIAT was proved as a miR-182-5p sponge and regulated the expression of GPRC5A that was a miR-182-5p target. 34553078 circFAT1 CircRNA Homo sapiens Adenocarcinoma of Lung A549 cells, LUAD tissues Interaction(miR-7/IRS2-ERK1/2) In Vivo Experiment//RNA Pull-Down//Northern Blot//Western Blot//CCK8//qRT-PCR//RNA-seq//Cell Apoptosis Assay//Luciferase Report Assay//BrdU//Cell Cycle Assay//Colony Formation Assay//IF We found that circFAT1 was one of the top expressed circRNAs in A549 cells by circRNA-seq and was significantly upregulated in human LUAD tissues.At molecular level, circFAT1 sequestered miR-7 to upregulate IRS2, which in turn regulated downstream ERK1/2 phosphorylation and CCND1 expression, ultimately promoting tumor progression. Yes Multiple cellular assays with A549 and PC9 LAUD cell lines under both gain-of-function and loss-of-function conditions demonstrated that circFAT1 promoted proliferation of LUAD cells in vitro and in vivo. In addition, we showed that DDP treatment was much more effective in circFAT1 knockdown tumor cells in vitro and in a xenograft tumor model. 35844799 MEG3 LncRNA Homo sapiens Melanoma carcinoma tissues regulation[miR-21/E-cadherin axis] CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The clinical data showed that lncRNA MEG3 and E-cadherin expressions were both declined in carcinoma tissues as compared with their para-carcinoma tissues.Our findings indicated that lncRNA MEG3 might inhibit the tumor growth, tumor metastasis and formation of melanoma by modulating miR-21/E-cadherin axis. Yes The results demonstrated that lncRNA MEG3 could suppress the tumor growth, tumor metastasis and formation; and meanwhile E-cadherin had the same effects on tumor growth, tumor metastasis and formation. 31938020 MIAT LncRNA Homo sapiens Pancreatic Carcinoma PC tissues and PC cell lines interaction[miR-133 ] Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay MIAT expression was found remarkably increased and miR-133 expression was significantly decreased in PC tissues and PC cell lines (PATU-8988, BxPC-3, PANC-1, SW1990 and AsPC-1 cells).Taken together, our results suggest that the interaction of MIAT and miR-133 play a role in the proliferation and metastasis of pancreatic carcinoma. PC patients with high MIAT level had poor prognosis than that with low MITA level. Yes The results exhibited that the inhibition of miR-133 expression reversed the inhibition effect of MIAT down-regulation in the growth, migration and invasion of PC cells. Moreover, tumor growth was tremendously suppressed in nude rats received injection of PATU-8988 cells transfected with siMIAT. 29772434 hsa_circ_0067934 CircRNA Homo sapiens Glioblastoma GBM tissues and cancer cells Interaction[PI3K-AKT pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay The expression level of hsa_circ_0067934 was significantly increased in GBM tissues and cancer cells. Moreover, the mechanistic analysis demonstrated that the down-regulation of hsa_circ_0067934 significantly suppressed the activation of the PI3K-AKT pathway. Kaplan-Meier survival curves showed that patients with higher expression of hsa_circ_0067934 had a more favorable overall survival and disease-free survival. Yes The functional investigations revealed that the knockdown of hsa_circ_0067934 suppressed GBM cell proliferation, metastasis and EMT, and promoted apoptosis. 31081099 NORAD LncRNA Homo sapiens Melanoma MM tissues Interaction[MIR-205-EGLN2 pathway] Western Blot//ISH//qRT-PCR//Luciferase Report Assay//Transwell Assay In this study, high expression of NORAD was firstly observed in melanoma tissues and human malignant melanoma cell lines.NORAD may play critical roles in tumorigenesis and progression of malignant melanoma by regulating of the miR-205-EGLN2 pathway, and may serve as a new therapeutic target. Yes In vitro, NORAD knockdown significantly inhibited migration and invasion of malignant melanoma cells and elevated the expression of miR-205, there was an interaction between miR-205 and NORAD in the RNA-induced silencing complex. 30843652 NEAT1 LncRNA Homo sapiens Chronic Periodontitis CP tissues and periodontitis model Interaction(miR-200c-3p/TRAF6 axis) Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//ELISA In this research, NEAT1 is up-regulated in CP tissues and periodontitis model group.Consequently, the silencing of NEAT1 inhibits inflammation and apoptosis via targeting miR-200c-3p/TRAF6 axis, thereby contributing to alleviate the progression of CP. Yes Silencing of NEAT1 and over-expression of miR-200c-3p enhanced cell viability and repressed apoptosis in the periodontitis model group.NEAT1 targets miR-200c-3p, and miR-200c-3p further targets TRAF6. MiR-200c-3p inhibitor or over-expression of TRAF6 reversed the promoting effect of NEAT1 knockdown on cell viability, and the inhibiting effects on inflammatory cytokines and cell apoptosis. 35034548 NORAD LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction(miR-363-3p/PEAK1/ERK) RNA Pull-Down//Western Blot//Invasion Assay//CCK8//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis We found that lncRNA NORAD was highly expressed in human NSCLC tissues and cell lines. Taken together, lncRNA NORAD upregulated the expression of PEAK1 through sponging miR-363-3p, and then activated the ERK signaling pathway, thereby promoting the development of NSCLC. Yes The CCK-8 assay results showed that lncRNA NORAD had no effect on cell proliferation. The Transwell assay and Western blotting results showed that overexpression of lncRNA NORAD promoted the invasion and epithelial-mesenchymal transition (EMT) of NSCLC cells. 33742335 NORAD LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells regulation[miR-495-3p/ TRIP13 axis] RNA Pull-Down//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay NORAD and TRIP13 were upregulated while miR-495-3p was downregulated in PCa tissues and cells.NORAD depletion inhibited PCa advancement via the miR-495-3p/ TRIP13 axis, which provided a potential tactic for PCa treatment. Yes Both NORAD silencing and miR-495-3p upregulation accelerated cell apoptosis and curbed cell proliferation, migration, and invasion in PCa cells. Also, NORAD silencing repressed tumor growth in vivo. 32694945 NORAD LncRNA Homo sapiens Prostatic Neoplasms PC tissues and cells regulation[miR-30a-5p/RAB11A/WNT/β-catenin pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay NORAD was upregulated in PC tissues and cells.Our results indicated a significant role of NORAD in mechanisms associated with PC progression. NORAD promoted cell proliferation, invasion and EMT via the miR-30a-5p/RAB11A/WNT/β-catenin pathway, thus inducing PC tumor growth. Yes Overexpression of NORAD promoted cell proliferation, invasion, EMT, and inhibited cell apoptosis; while knockdown of NORAD had the opposite effect. 33292272 MEG3 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC cells Interaction(miR-21/PTEN ) In Vivo Experiment//Western Blot//Tunel//Flow Cytometry//qRT-PCR//RIP//FISH//Luciferase Report Assay//IHC//IF As determined by RT-qPCR, MEG3 expression was down-regulated in NPC cells. Online RNA crosstalk analysis predicted the binding of miR-21 to MEG3 and PTEN, respectively. MEG3 was validated to bind to miR-21 while PTEN was identified as a target of miR-21 by dual-luciferase reporter gene assay. Exogenous transfection was done to change the levels of MEG3, miR-21 and PTEN in HK-1 cells to investigate their effects on the autophagy and apoptosis of NPC cells. The results suggested that MEG3 overexpression in HK-1 cells up-regulated PTEN and down-regulated miR-21, by which MEG3 further inhibited autophagy and apoptosis ability of NPC cells. Yes The results suggested that MEG3 overexpression in HK-1 cells up-regulated PTEN and down-regulated miR-21, by which MEG3 further inhibited autophagy and apoptosis ability of NPC cells. The tumour formation ability was tested after injecting the HK-1 cells into nude, mice and tumour growth was monitored. 33332708 hsa_circ_0004788 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Interaction(circ_0004788/miR-515-5p/FGF2 network) In Vivo Experiment//Wound Healing Assay//Tube Formation Assay//CCK8//Flow Cytometry//Colony Formation Assay//Invasion Assay//Transwell Assay Circ_0004788 and fibroblast growth factor 2 (FGF2) were significantly elevated, and microRNA-515-5p (miR-515-5p) was dramatically decreased in NPC tissues and cells. Yes The impacts of circ_0004788 knockdown on cell progression in NPC cells were reversed by miR-515-5p inhibitor, and FGF2 overexpression could block the suppressive effect of miR-515-5p on cell progression in NPC cells. 35460538 MEG3 LncRNA Homo sapiens Colitis, Ulcerative UC cell Interaction(miR-20b-5p/CREB1 ) Western Blot//Tunel//CCK8//Flow Cytometry//FISH//RIP//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA//Bioinformatics Analysis Collectively, our findings revealed that M2-EVs carrying MEG3 enhanced UC cell viability and reduced inflammatory responses via the miR-20b-5p/CREB1 axis, thus alleviating UC inflammation. Yes UC mice presented with shortened colon length, lightened weight, increased DAI score, enhanced apoptosis, and significant inflammatory cell infiltration, while M2-EVs reversed these trends. In vitro, M2-EVs increased UC cell viability and reduced inflammation. 34895044 NORAD LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tissues and cells regulation[miR-520a-3p/PI3k/Akt/mTOR signaling pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Compared with normal tissues and cells, the expressions of lncRNA NORAD in cancer tissues and cells were significantly higher. LncRNA NORAD can regulate the proliferation of NSCLC by regulating miR-520a-3p/PI3k/Akt/mTOR signaling pathway, thus promoting the occurrence and development of NSCLC. Yes LncRNA NORAD could accelerate the growth and metastasis of NSCLC in vitro and in vivo. 32110050 NORAD LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Interaction(microRNA-541-3p/PKM2) In Vivo Experiment//Western Blot//qRT-PCR//FISH//IF//Luciferase Report Assay//Transwell Assay PCa tissues and cell lines were observed to have a high expression of NORAD, particularly in tissues with bone metastasis.It was indicated that NORAD interacted with miR-541-3p, leading to the upregulation of PKM2. Forced expression of PKM2 promoted the transfer of PKH67-labeled EVs to bone marrow stromal cells. Yes NORAD knockdown resulted in reduced secretion and internalization of EVs, and suppressed proliferation, migration, and bone metastasis of PCa cells. 33722248 MEG3 LncRNA Homo sapiens Neuroblastoma 60 NB tissues and 20 adjacent tissues, cells Interaction(EZH2) In Vivo Experiment//IHC//Western Blot//Migration Assay//qRT-PCR//RIP//ChIP-seq//RNA-seq//Colony Formation Assay//Invasion Assay Q-PCR revealed that MEG3 expression was negatively correlated with INSS stage and risk grade of NB. MEG3 exerted an anti-cancer effect via stimulatory effects on EZH2 ubiquitination leading to its degradation. Conversely, EZH2 interacted with DNMT1 and HDAC1 to induce silencing of MEG3. In conclusion, downregulation of MEG3 and upregulation of EZH2 forms a feedback loop that concertedly promotes the development of NB. Q-PCR revealed that MEG3 expression was negatively correlated with INSS stage and risk grade of NB. Yes MEG3 overexpression was associated with inhibition of NB growth in vivo. 35257481 circADAMTS6 CircRNA Homo sapiens Glioblastoma gliblastoma patients Interaction(ANXA2/ NF-κB pathway) In Vivo Experiment//Tunel//Flow Cytometry//qRT-PCR//CCK8//Microarray Herein, we identified an unreported circRNA (hsa-circ-0072688, also named circADAMTS6) that is specifically upregulated in the hypoxic microenvironment of glioblastoma and closely correlated with poor prognosis of gliblastoma patients. Mechanistically, the hypoxic tumour microenvironment upregulates circADAMTS6 expression through transcription factor activator protein 1 (AP-1) and RNA-binding protein TAR DNA-binding protein 43 (TDP43). Moreover, circADAMTS6 accelerates glioblastoma progression by recruiting and stabilising annexin A2 (ANXA2) in a proteasomes-dependent manner. Furthermore, we found T-5224 (AP-1 inhibitor) treatment induces downregulation of circADAMTS6 and then inhibits tumour growth. Yes We found that circADAMTS6 promotes the malignant progression of glioblastoma by promoting cell proliferation and inhibiting apoptosis. 36396726 NORAD LncRNA Homo sapiens Lung Neoplasms lung epithelial cells and LC cells Interaction(miR-28-3p with E2F2) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay NORAD was overexpressed in LC cells and NORAD knockout led to suppressed LC cell proliferation, invasion, and migration. Besides, NORAD targeted miR-28-3p and miR-28-3p targeted E2F2 transcription. Inhibiting miR-28-3p or overexpressing E2F2 could both annul the inhibitory role of si-NORAD in LC cell proliferation, invasion, and migration. Generally, our findings demonstrated that NORAD competitively bound to miR-28-3p with E2F2, to promote LC cell progression. Yes NORAD was overexpressed in LC cells and NORAD knockout led to suppressed LC cell proliferation, invasion, and migration. 36245705 NORAD LncRNA Homo sapiens Thyroid Neoplasms PTC cell lines Interaction(miR-451) CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results of RT-qPCR and Western blotting suggested that the expression of lncRNA NORAD and IL-6R were higher than that of the control group, while the expression of miR-451 was lower. Yes Transwell assay indicated that the knockdown of lncRNA NORAD or overexpression of miR-451 significantly inhibited cell proliferation, migration and invasion in PTC cell lines. 34730199 NORAD LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction( miRNA-455/CDK14 axis) Luciferase Report Assay NORAD was upregulated in NSCLC tissues and cells. MiRNA-455 was the downstream target binding to NORAD. Its level was negatively regulated by NORAD. Knockdown of miRNA-455 could reverse the role of NORAD in regulating the proliferative ability of NSCLC. Moreover, CDK14 was the target gene of miRNA-455. CDK14 level was negatively regulated by miRNA-455. Its level was higher in NSCLC patients with advanced stage or accompanied with lymphatic metastasis. Worse prognosis was observed in NSCLC patients presenting high level of NORAD. Yes Silence of NORAD attenuated the proliferative ability of NCI-H1650 and HCC827 cells. 33764714 NORAD LncRNA Homo sapiens Thyroid Neoplasms PTC tissues,cell lines Interaction[targeting miR-202-5p] CCK8//qRT-PCR//Western Blot In this study, we demonstrated that NORAD expression was upregulated in PTC cell lines and samples. These results suggested that the lncRNA NORAD acts as an oncogene in PTC progression, partly by regulating miR-202-5p expression. Yes Ectopic expression of NORAD promoted PTC cell growth, invasion and migration. 30787987 NORAD LncRNA Homo sapiens Prostatic Neoplasms cancer cells Interaction(miR-346) In Vivo Experiment//qRT-PCR//RNA-seq miR-346 also interacts with genome-protective lncRNA NORAD to disrupt its interaction with PUM2, leading to PUM2 stabilisation and its increased turnover of DNA damage response (DDR) transcripts. Confirming clinical relevance, NORAD expression and activity strongly correlate with poor PC clinical outcomes and increased DDR in biopsy RNA-seq studies. In contrast, miR-346 is associated with improved PC survival. Yes Further, RNA-seq reveals widespread miR-346 and shNORAD dysregulation of DNA damage, replication and cell cycle processes. NORAD drives target-directed miR decay (TDMD) of miR-346 as a novel genome protection mechanism: NORAD silencing increases mature miR-346 levels by several thousand-fold, and WT but not TDMD-mutant NORAD rescues miR-346-induced DNA damage. Importantly, miR-346 sensitises PC cells to DNA-damaging drugs including PARP inhibitor and chemotherapy, and induces tumour regression as a monotherapy in vivo, indicating that targeting miR-346 35317841 Neat1 LncRNA Mus musculus Sepsis brain tissues Interaction[NF-κB] qRT-PCR//MTT//Tunel//Western Blot The relative expression levels of NEAT1 and NF-κB were significantly increased in the brain tissues of septic mice (p<0.01). Si-NEAT1 transfection significantly decreased the expressions of NEAT1 and NF-κB in brain tissues of septic mice (p<0.05). Yes The content of brain water in mice of sepsis group was evidently increased (p<0.05). However, si-NEAT1 treatment remarkably reduced this content (p<0.05). In addition, sepsis markedly decreased the activity of nerve cells (p<0.05). However, si-NEAT1 could significantly increase the activity of nerve cells in septic mice (p<0.05).In addition, si-NEAT1 transfection could evidently alleviate the apoptosis of nerve cells in septic mice (p<0.05). 31115021 hsa_circ_0000523 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cell lines Interaction(miR-1184/COL1A1/PI3K/Akt pathway ) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Circ_0000523 and COL1A1 mRNA expressions were significantly increased in NPC tissues and cell lines. MiR-1184 was the downstream target of circ_0000523, and COL1A1 was the target gene of miR-1184 and could be positively modulated by circ_0000523. COL1A1 overexpression increased the expression levels of p-p85 and p-Akt, whereas knocking down COL1A1 repressed their expressions. Yes Circ_0000523 overexpression promoted NPC cell proliferation and accelerated cell cycle progression, whereas miR-1184 overexpression reversed these effects; circ_0000523 knockdown suppressed NPC cell proliferation and induced cell cycle arrest, while miR-1184 inhibition counteracted these effects. 35759163 MIAT LncRNA Homo sapiens acute myocardial infarction blood Expression[highly expressed] qRT-PCR The results showed that the plasma levels of MIAT were significantly increased in patients with AMI compared with non‑AMI patients. Yes Knockdown of MIAT significantly inhibited cardiomyocyte apoptosis. 31661125 MEG3 LncRNA Homo sapiens Nasopharyngeal carcinoma cell lines interaction[miR-543,KLF4] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results showed that MEG3 was decreased and miR-543 was increased in NPC cell lines, and upregulated MEG3 inhibited cell proliferation, migration, and invasion and promoted apoptosis, suggesting that MEG3 acts as a tumor suppressor in NPC cells.These findings show that lncRNA MEG3 inhibits the development of NPC by sponging miR-543 targeting KLF4 and that MEG3 can serve as a new novel target for NPC therapeutics. Yes The results showed that MEG3 was decreased and miR-543 was increased in NPC cell lines, and upregulated MEG3 inhibited cell proliferation, migration, and invasion and promoted apoptosis, suggesting that MEG3 acts as a tumor suppressor in NPC cells. 35117441 hsa_circ_006020 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3613 No 31026505 hsa_circ_0001681 CircRNA Homo sapiens COVID-19 human lung epithelial cells Regulation qRT-PCR A total of 8 significantly dysregulated circRNAs, including hsa_circ_0000566, hsa_circ_0060927, hsa_circ_0067985, circRNA_04769, hsa_circ_0001681, hsa_circ_0080941, hsa_circ_0080942, hsa_circ_0005630, were selected to verify the change in expression in response to SARS-CoV-2 infection by qRT-PCR experiments. No 34004360 hsa_circ_002383 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7303 No 31026505 mmu_circ_28028 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[highly expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_001099 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3542 No 31026505 hsa_circ_000740 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3556 No 31026505 mmu_circ_29981 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[highly expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_04769 CircRNA Homo sapiens COVID-19 human lung epithelial cells Regulation qRT-PCR A total of 8 significantly dysregulated circRNAs, including hsa_circ_0000566, hsa_circ_0060927, hsa_circ_0067985, circRNA_04769, hsa_circ_0001681, hsa_circ_0080941, hsa_circ_0080942, hsa_circ_0005630, were selected to verify the change in expression in response to SARS-CoV-2 infection by qRT-PCR experiments. No 34004360 hsa_circ_003797 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3679 No 31026505 hsa_circ_005018 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7323 No 31026505 mmu_circ_007438 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 354 down-regulated circRNAs were identified. No 31692917 hsa_circ_002311 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3543 No 31026505 hsa_circ_005324 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3555 No 31026505 hsa_circ_002385 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7316 No 31026505 hsa_circ_001551 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3687 No 31026505 hsa_circ_001216 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7317 No 31026505 hsa_circ_0006365 CircRNA Homo sapiens Astrocytoma serum exosome Regulation qRT-PCR//RNA-seq Moreover, a serum exosome circRNA panel including hsa_circ_0075828, hsa_circ_0003828, and hsa_circ_0002976 could be used to screen for HGA, whereas a good prognosis panel comprised high concentrations of hsa_circ_0005019, hsa_circ_0000880, hsa_circ_0051680, and hsa_circ_0006365. No 34942001 hsa_circ_000614 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7318 No 31026505 hsa_circ_0080942 CircRNA Homo sapiens COVID-19 human lung epithelial cells Regulation qRT-PCR A total of 8 significantly dysregulated circRNAs, including hsa_circ_0000566, hsa_circ_0060927, hsa_circ_0067985, circRNA_04769, hsa_circ_0001681, hsa_circ_0080941, hsa_circ_0080942, hsa_circ_0005630, were selected to verify the change in expression in response to SARS-CoV-2 infection by qRT-PCR experiments. No 34004360 hsa_circ_003764 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7322 No 31026505 hsa_circ_005341 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7319 No 31026505 hsa_circ_001202 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7320 No 31026505 mmu_circ_29980 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[highly expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_004439 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7321 No 31026505 hsa_circ_0080941 CircRNA Homo sapiens COVID-19 human lung epithelial cells Regulation qRT-PCR A total of 8 significantly dysregulated circRNAs, including hsa_circ_0000566, hsa_circ_0060927, hsa_circ_0067985, circRNA_04769, hsa_circ_0001681, hsa_circ_0080941, hsa_circ_0080942, hsa_circ_0005630, were selected to verify the change in expression in response to SARS-CoV-2 infection by qRT-PCR experiments. No 34004360 mmu_circ_39832 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[highly expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 mmu_circ_31992 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 355 down-regulated circRNAs were identified. No 31692917 hsa_circ_001625 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7302 No 31026505 hsa_circ_3205 CircRNA Homo sapiens SARS-CoV-2 SARS-CoV-2 infected cells Interaction( miR-298/KCNMB4 and PRKCE) Other Our results showed that the predicted SARS-CoV-2 circ_3205 was expressed only in positive samples and its amount positively correlated with that of SARS-CoV-2 Spike (S) mRNA and the viral load (r values = 0.80952 and 0.84867, Spearman's correlation test, respectively). Human (hsa) miR-298 was predicted to interact with circ_3205 by all three predictive tools. KCNMB4 and PRKCE were predicted as hsa-miR-298 targets. No 35039944 hsa_circ_003604 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3614 No 31026505 hsa_circ_005233 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3559 No 31026505 hsa_circ_001105 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3557 No 31026505 hsa_circ_005494 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3558 No 31026505 hsa_circ_006019 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3598 No 31026505 hsa_circ_0060927 CircRNA Homo sapiens COVID-19 human lung epithelial cells Regulation qRT-PCR A total of 8 significantly dysregulated circRNAs, including hsa_circ_0000566, hsa_circ_0060927, hsa_circ_0067985, circRNA_04769, hsa_circ_0001681, hsa_circ_0080941, hsa_circ_0080942, hsa_circ_0005630, were selected to verify the change in expression in response to SARS-CoV-2 infection by qRT-PCR experiments. No 34004360 hsa_circ_006533 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3597 No 31026505 hsa_circ_0000566 CircRNA Homo sapiens COVID-19 human lung epithelial cells Regulation qRT-PCR A total of 8 significantly dysregulated circRNAs, including hsa_circ_0000566, hsa_circ_0060927, hsa_circ_0067985, circRNA_04769, hsa_circ_0001681, hsa_circ_0080941, hsa_circ_0080942, hsa_circ_0005630, were selected to verify the change in expression in response to SARS-CoV-2 infection by qRT-PCR experiments. No 34004360 hsa_circ_0008925 CircRNA Homo sapiens renal fibrosis HK-2 cells Expression(highly expressed) Western Blot The results showed that in exosomes derived from TGF-β1-cultured HK-2 cells, the expression of hsa_circ_0008925 was increased compared with normal cultured. Further, the expression level of hsa_circ_0008925 was increased in urinary exosomes from renal fibrosis patients and correlated with serum creatinine, blood urea nitrogen (BUN), estimated glomerular filtration rate, and cystatin C. The level of hsa_circ_0008925 was furthermore correlated with the score of tubulointerstitial fibrosis (TIF) and the score of glomerular sclerosis. The ROC curve showed that hsa_circ_0008925 can diagnose renal fibrosis at a cut-off value of 0.093 with a sensitivity of 52.2% and specificity of 96.4%. In summary, we indicated that urinary exosomal hsa_circ_0008925 could be acted as a noninvasive biomarker for renal fibrosis in glomerular diseases patients. No 35222740 hsa_circ_003729 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3541 No 31026505 hsa_circ_006532 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3596 No 31026505 hsa_circ_006522 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3595 No 31026505 hsa_circ_007165 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7298 No 31026505 hsa_circ_002200 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3538 No 31026505 hsa_circ_006640 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3594 No 31026505 hsa_circ_005825 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3560 No 31026505 hsa_circ_003643 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3688 No 31026505 mmu_circ_20332 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 359 down-regulated circRNAs were identified. No 31692917 hsa_circ_002523 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3539 No 31026505 hsa_circ_0067985 CircRNA Homo sapiens COVID-19 human lung epithelial cells Regulation qRT-PCR A total of 8 significantly dysregulated circRNAs, including hsa_circ_0000566, hsa_circ_0060927, hsa_circ_0067985, circRNA_04769, hsa_circ_0001681, hsa_circ_0080941, hsa_circ_0080942, hsa_circ_0005630, were selected to verify the change in expression in response to SARS-CoV-2 infection by qRT-PCR experiments. No 34004360 hsa_circ_002654 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7299 No 31026505 hsa_circ_061346 CircRNA Homo sapiens Retinal Diseases peripheral blood mononuclear cells Regulation qRT-PCR//Bioinformatics Analysis//Microarray Three circRNAs (hsa_circRNA_061346, hsa_circRNA_092369, and hsa_circRNA_103554) were identified as potential diagnostic biomarkers for ROP with certain clinical values. No 36081509 mmu_circ_004355 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 358 down-regulated circRNAs were identified. No 31692917 hsa_circ_002631 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7300 No 31026505 hsa_circ_003471 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7326 No 31026505 hsa_circ_000834 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7301 No 31026505 hsa_circ_006738 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7325 No 31026505 hsa_circ_003021 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3540 No 31026505 mmu_circ_36065 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 357 down-regulated circRNAs were identified. No 31692917 hsa_circ_007160 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3611 No 31026505 hsa_circ_001036 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7324 No 31026505 hsa_circ_0036877 CircRNA Homo sapiens Pre-Eclampsia htra-8 cells Regulation H&E Staining//RIP//qRT-PCR//FISH//Microarray//Bioinformatics Analysis RNA immunoprecipitation (RIP) of AGO2 in htra-8 cells and qRT-PCR analysis of hsa_circ_0036877 expression in maternal whole peripheral blood samples of participants were then conducted to confirm that hsa_circ_0036877 is a ceRNA and potential novel blood biomarker for early PE, respectively. No 29643944 mmu_circ_29319 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 356 down-regulated circRNAs were identified. No 31692917 hsa_circ_002252 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3612 No 31026505 hsa_circ_0051680 CircRNA Homo sapiens Astrocytoma serum exosome Regulation qRT-PCR//RNA-seq Moreover, a serum exosome circRNA panel including hsa_circ_0075828, hsa_circ_0003828, and hsa_circ_0002976 could be used to screen for HGA, whereas a good prognosis panel comprised high concentrations of hsa_circ_0005019, hsa_circ_0000880, hsa_circ_0051680, and hsa_circ_0006365. No 34942001 hsa_circ_001223 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3610 No 31026505 hsa_circ_000265 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7315 No 31026505 hsa_circ_004403 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3671 No 31026505 hsa_circ_001342 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3548 No 31026505 hsa_circ_003825 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3683 No 31026505 hsa_circ_002254 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3684 No 31026505 hsa_circ_002108 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3685 No 31026505 mmu_circ_21453 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[highly expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_0002976 CircRNA Homo sapiens Astrocytoma serum exosome Regulation qRT-PCR//RNA-seq Moreover, a serum exosome circRNA panel including hsa_circ_0075828, hsa_circ_0003828, and hsa_circ_0002976 could be used to screen for HGA, whereas a good prognosis panel comprised high concentrations of hsa_circ_0005019, hsa_circ_0000880, hsa_circ_0051680, and hsa_circ_0006365. No 34942001 hsa_circ_000354 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3549 No 31026505 hsa_circ_004446 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7306 No 31026505 hsa_circ_003456 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3601 No 31026505 hsa_circ_004463 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3670 No 31026505 hsa_circ_001523 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3669 No 31026505 hsa_circ_006575 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3550 No 31026505 hsa_circ_000333 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3668 No 31026505 hsa_circ_005743 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3602 No 31026505 hsa_circ_001773 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3672 No 31026505 hsa_circ_0044226 CircRNA Mus musculus Idiopathic Pulmonary Fibrosis lung tissues,cell line Expression[highly expressed] Western Blot//CCK8//qRT-PCR//FISH//Luciferase Report Assay//IHC The circ0044226 was upregulated while miR-7 was downregulated in IPF mice model and FMT-derived myofibroblasts. No 31786325 hsa_circ_002364 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3547 No 31026505 hsa_circ_001398 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3676 No 31026505 hsa_circ_002512 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3546 No 31026505 hsa_circ_002202 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3573 No 31026505 hsa_circ_001887 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3678 No 31026505 hsa_circ_006364 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3599 No 31026505 hsa_circ_001410 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3680 No 31026505 hsa_circ_005574 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3677 No 31026505 hsa_circ_002217 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3675 No 31026505 hsa_circ_006708 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3544 No 31026505 hsa_circ_003032 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3681 No 31026505 hsa_circ_004458 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3674 No 31026505 hsa_circ_000493 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3572 No 31026505 hsa_circ_002285 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3571 No 31026505 hsa_circ_002786 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3673 No 31026505 hsa_circ_004561 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3682 No 31026505 hsa_circ_002590 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3667 No 31026505 hsa_circ_000845 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3603 No 31026505 hsa_circ_004905 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3664 No 31026505 hsa_circ_0000880 CircRNA Homo sapiens Astrocytoma serum exosome Regulation qRT-PCR//RNA-seq Moreover, a serum exosome circRNA panel including hsa_circ_0075828, hsa_circ_0003828, and hsa_circ_0002976 could be used to screen for HGA, whereas a good prognosis panel comprised high concentrations of hsa_circ_0005019, hsa_circ_0000880, hsa_circ_0051680, and hsa_circ_0006365. No 34942001 mmu_circ_21454 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[highly expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_005358 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7313 No 31026505 hsa_circ_003655 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3552 No 31026505 hsa_circ_000122 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7314 No 31026505 hsa_circ_007189 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3553 No 31026505 mmu_circ_40141 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[highly expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_0005630 CircRNA Homo sapiens COVID-19 human lung epithelial cells Regulation qRT-PCR A total of 8 significantly dysregulated circRNAs, including hsa_circ_0000566, hsa_circ_0060927, hsa_circ_0067985, circRNA_04769, hsa_circ_0001681, hsa_circ_0080941, hsa_circ_0080942, hsa_circ_0005630, were selected to verify the change in expression in response to SARS-CoV-2 infection by qRT-PCR experiments. No 34004360 hsa_circ_002936 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7304 No 31026505 hsa_circ_003172 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3607 No 31026505 hsa_circ_007074 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3545 No 31026505 hsa_circ_006511 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3608 No 31026505 hsa_circ_003145 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3686 No 31026505 hsa_circ_007275 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3554 No 31026505 hsa_circ_003665 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3609 No 31026505 mmu_circ_30398 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[highly expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_000510 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7305 No 31026505 hsa_circ_005846 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3604 No 31026505 hsa_circ_001802 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3606 No 31026505 hsa_circ_004661 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3666 No 31026505 hsa_circ_001229 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7307 No 31026505 hsa_circ_006729 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3605 No 31026505 hsa_circ_003898 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3551 No 31026505 hsa_circ_0005019 CircRNA Homo sapiens Astrocytoma serum exosome Regulation qRT-PCR//RNA-seq Moreover, a serum exosome circRNA panel including hsa_circ_0075828, hsa_circ_0003828, and hsa_circ_0002976 could be used to screen for HGA, whereas a good prognosis panel comprised high concentrations of hsa_circ_0005019, hsa_circ_0000880, hsa_circ_0051680, and hsa_circ_0006365. No 34942001 hsa_circ_0003828 CircRNA Homo sapiens Astrocytoma serum exosome Regulation qRT-PCR//RNA-seq Moreover, a serum exosome circRNA panel including hsa_circ_0075828, hsa_circ_0003828, and hsa_circ_0002976 could be used to screen for HGA, whereas a good prognosis panel comprised high concentrations of hsa_circ_0005019, hsa_circ_0000880, hsa_circ_0051680, and hsa_circ_0006365. No 34942001 mmu_circ_34829 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[highly expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_002142 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7312 No 31026505 hsa_circ_003454 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7308 No 31026505 hsa_circ_001479 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7309 No 31026505 hsa_circ_000667 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3665 No 31026505 hsa_circ_002028 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7310 No 31026505 hsa_circ_000142 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7311 No 31026505 hsa_circ_0075828 CircRNA Homo sapiens Astrocytoma serum exosome Regulation qRT-PCR//RNA-seq Moreover, a serum exosome circRNA panel including hsa_circ_0075828, hsa_circ_0003828, and hsa_circ_0002976 could be used to screen for HGA, whereas a good prognosis panel comprised high concentrations of hsa_circ_0005019, hsa_circ_0000880, hsa_circ_0051680, and hsa_circ_0006365. No 34942001 hsa_circ_0007367 CircRNA Homo sapiens Heart Arrest animals and PMVECs exposed to pulsatile flow Interaction( zonula occludens- (ZO-) 1 and occludin/eNOS/NF-κB) In Vivo Experiment//qRT-PCR//IF//Western Blot the expression of hsa_circ_0007367 was significantly upregulated both in animals and PMVECs exposed to pulsatile flow. In particular, upregulation of hsa_circ_0007367 stabilized the expressions of endothelial tight junction markers zonula occludens- (ZO-) 1 and occludin, followed by modulating the endothelial nitric oxide synthases (eNOS) activity and inhibiting the NF-κB signaling pathway. No 35222790 mmu_circ_008009 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 377 down-regulated circRNAs were identified. No 31692917 hsa_circ_005741 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3570 No 31026505 hsa_circ_0028381 CircRNA Homo sapiens Vasculitis plasma Expression(highly expressed) qRT-PCR//RNA-seq qRT-PCR verification suggested that hsa_circ_0028381 levels were significantly increased in plasma from AAV patients compared to those in HCs and other CTDs. In addition, hsa_circ_0028381 was associated with renal involvement. Most importantly, increased baseline levels of hsa_circ_0028381 had predictive value for progression to end-stage renal disease (ESRD). No 36441649 hsa_circ_001399 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3582 No 31026505 hsa_circ_004012 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3628 No 31026505 mmu_circ_36832 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 373 down-regulated circRNAs were identified. No 31692917 hsa_circ_0000301 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer Interaction(miR-1228-3p/IRF4 Axis) Bioinformatics Analysis From above concern, it can conclude that hsa_circ_0000301/hsa-miR-1228-3p/IRF4 may be involved in the occurrence and development of cervical cancer. No 34020619 circRAPGEF5 CircRNA Homo sapiens Thyroid Cancer, Papillary blood Expression[highly expressed] qRT-PCR Individual qRT-PCR identification showed that two circRNAs (circRAPGEF5 and hsa_circ_0058124) were significantly up-regulated in PTC patients compared with HCs and thyroid nodules. No 32547069 hsa_circ_0058124 CircRNA Homo sapiens Thyroid Cancer, Papillary blood Expression[highly expressed] qRT-PCR Individual qRT-PCR identification showed that two circRNAs (circRAPGEF5 and hsa_circ_0058125) were significantly up-regulated in PTC patients compared with HCs and thyroid nodules. No 32547069 circMTO1 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues, cell lines Expression[highly expressed] qRT-PCR circMTO1 was shown to be greatly upregulated in cervical cancer cell lines and tumors. No 31226633 hsa_circ_0107593 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues, cell line interaction[ binding with hsa-miR-20a-5p/93-5p/106b-5p] qRT-PCR The results revealed that hsa_circ_0107593 has low expression in CC tissues and CC cell lines.Collectively, our study implies that hsa_circ_0107593 has tumor-suppressing activity in CC by physically binding with hsa-miR-20a-5p, hsa-miR-93-5p, and hsa-miR-106b-5p. Moreover, negative correlations of hsa_circ_0107593 expression were found against tumor diameter, FIGO stage, and myometrial invasion. Also, hsa_circ_0107593 impedes CC cell proliferation, migration, and invasion. Based on ROC curve analysis, hsa_circ_0107593 could serve as a diagnostic biomarker. Its low expression may indicate increased patient's risk to developing cervical cancer. No 33585208 circMETRN CircRNA Homo sapiens Glioblastoma glioblastoma cells Regulation(miR-4709-3p/GRB14/PDGFRα pathway) In Vivo Experiment//Western Blot//Wound Healing Assay//FISH//qRT-PCR//MTT//Luciferase Report Assay//Cell Apoptosis Assay//Microarray//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay Results in the present study revealed that low-dose radiation stimulated the secretion of ldrEXOs which delivered high levels of circ-METRN. And circ-METRN-abundant ldrEXOs increased the expression of γ-H2AX, indicating an efficient DNA damage-repair process in glioblastoma cells. The ldrEXOs-derived circ-METRN enhanced the glioblastoma progression and radioresistance via miR-4709-3p/GRB14/PDGFRα pathway. Up-regulating PDGFRα can rescue the tumor-promoting function of ldrEXOs in groups previously treated with inhibition of GRB14. Additionally, in-vivo experiments revealed that treatments with ldrEXOs promoted the growth of xenografted tumors and shortened the survival period. Furthermore, clinical researches indicated that circ-METRN may be transported into the bloodstream by exosomes in the early stages of fractionated radiotherapy. It has important clinical values to detect the serum exosomal circ-METRN in the early stage of radiotherapy, which is not only conducive to predict radioresistance and prognosis but also to assist MRI diagnosis in detecting the very early recurrence of glioblastoma. In summary, this study reveals for the first time that low-dose radiation-induced exosomal circ-METRN plays an oncogenic role in glioblastoma progression and radioresistance through miR-4709-3p/GRB14/PDGFRα pathway, providing mechanistic insights into the roles of circRNAs and a valuable marker for therapeutic targets in glioblastoma. Additionally, in-vivo experiments revealed that treatments with ldrEXOs promoted the growth of xenografted tumors and shortened the survival period. Furthermore, clinical researches indicated that circ-METRN may be transported into the bloodstream by exosomes in the early stages of fractionated radiotherapy. It has important clinical values to detect the serum exosomal circ-METRN in the early stage of radiotherapy, which is not only conducive to predict radioresistance and prognosis but also to assist MRI diagnosis in detecting the very early recurrence of glioblastoma. No 33867829 hsa_circ_006025 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3626 No 31026505 circCDKN2B-AS1 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues interaction[IMP3,HK2] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//RIP//Transwell Assay CircCDKN2B-AS1, a circular isoform of the long noncoding RNA (lncRNA) CDKN2B-AS1, was upregulated in cervical cancer and precancerous tissues. Our findings demonstrate that circCDKN2B-AS1 facilitates aerobic glycolysis by sponging the IMP3 protein to stabilize HK2 mRNA, consequently promoting the malignant phenotype in cervical cancer, which may provide a potential approach for cervical cancer therapeutics. No 33308298 hsa_circ_005234 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3578 No 31026505 mmu_circ_002573 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] qRT-PCR//Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 394 down-regulated circRNAs were identified. No 31692917 mmu_circ_39101 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 393 down-regulated circRNAs were identified. No 31692917 mmu_circ_18971 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 392 down-regulated circRNAs were identified. No 31692917 mmu_circ_006860 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 391 down-regulated circRNAs were identified. No 31692917 hsa_circ_000587 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3629 No 31026505 hsa_circ_002644 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3645 No 31026505 hsa_circ_001615 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3627 No 31026505 hsa_circ_0058124 CircRNA Homo sapiens Thyroid Neoplasms PTC tissue Regulation[NOTCH3/GATAD2A axis] qRT-PCR//Western Blot//FISH Quantitative real-time polymerase chain reaction (qRT-PCR) assays revealed a significant upregulation of hsa_circ_0058124 in PTC tissue and a close correlation with a poor prognosis for PTC patients. Hsa_circ_0058124 is associated with the malignant features and poor outcomes of PTC patients. Hsa_circ_0058124 acts as an oncogenic driver that promotes PTC cell proliferation, tumorigenicity, tumor invasion, and metastasis, which functions as a competing endogenous RNA to modulate miRNA-218-5p and its target gene NUMB expression, and consequently with repression of the NOTCH3/GATAD2A signaling axis in vitro and in vivo. No 31324198 hsa_circ_004872 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3650 No 31026505 hsa_circ_006554 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3600 No 31026505 hsa_circ_005902 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3649 No 31026505 hsa_circ_000531 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3577 No 31026505 hsa_circ_0006896 CircRNA Homo sapiens Atherosclerosis serum of UA and SA patients Interaction(miR1264‑DNMT1 axis) Western Blot//Wound Healing Assay//Migration Assay//FISH//qRT-PCR//MTT//Luciferase Report Assay//Microarray//Transwell Assay The expression of circRNA‑0006896 was positively correlated with triglyceride, low‑density lipoprotein cholesterol (LDL‑C) and C‑reactive protein levels, and negatively correlated with albumin levels in patients with UA. However, circRNA‑0006896 expression was positively correlated with LDL‑C in patients with SA. Additionally, in HUVECs treated with serum‑Exos derived from patients with UA, the expression of circRNA‑0006896 in HUVECs was upregulated. This was accompanied by decreased expression of microRNA‑1264 and SOCS3, increased levels of DNMT1 and phosphorylated STAT3. No 33649864 mmu_circ_40299 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 369 down-regulated circRNAs were identified. No 31692917 mmu_circ_007784 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 370 down-regulated circRNAs were identified. No 31692917 mmu_circ_26096 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 371 down-regulated circRNAs were identified. No 31692917 mmu_circ_008234 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[lower expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_002817 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3625 No 31026505 circN4BP2L2 CircRNA Homo sapiens Carcinoma, Ovarian Epithelial patient Expression(lower expressed) qRT-PCR//ELISA Low level of circN4BP2L2 was associated with advanced tumor stage (p < 0.01) in type I EOC. Decreased circN4BP2L2 was associated with lymph node metastasis (LNM) (p = 0.04) in type II EOC.The expression level of circN4BP2L2 in type I was similar to that in type II. Low level of circN4BP2L2 was associated with advanced tumor stage (p < 0.01) in type I EOC.Decreased circN4BP2L2 was associated with lymph node metastasis (LNM) (p = 0.04) in type II EOC. No 36434559 mmu_circ_31317 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[lower expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 circLRRC7 CircRNA Homo sapiens Glioblastoma GBM tissues Interaction(miR-1281 and PDXP Expression) qRT-PCR Through bioinformatic analysis followed by experimental validation, we found that hsa_circ_0114014 (circLRRC7) was dramatically down-regulated in GBM when compared with normal brain tissues (p < 0.0001). In summary, circLRRC7 may be a tumor suppressor that associated with miR-1281 and PDXP expression in GBM, which may provide novel therapeutic targets for GBM treatment. GBM patients with a lower circLRRC7 expression had poorer progression-free survival (PFS, p < 0.05) and overall survival (OS, p < 0.05). No 34912844 circADAMTS6 CircRNA Homo sapiens Cholangiocarcinoma tumor tissues and plasma exosomes of Asian patients with ICC Expression(highly expressed) qRT-PCR//RNA-seq The levels of circ-PTPN22 (hsa_circ_0110529) and circ-ADAMTS6 (hsa_circ_0072688), potential circRNA biomarkers, were elevated in the ICC tumor tissues and plasma exosomes of this subgroup than in the other subgroups and normal controls. Our results revealed a subgroup of Asian ICC characterized by T cell exhaustion and neutrophil extracellular traps and marked by elevated levels of circ-PTPN22 and circ-ADAMTS6 in tumor tissues and plasma exosomes. No 36700045 hsa_circ_003561 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3583 No 31026505 hsa_circ_0002171 CircRNA Homo sapiens Pneumonia Regulation qRT-PCR//RNA-seq In particular, hsa_circ_0002171 was differentially expressed in both groups and might thus be useful as a diagnostic biomarker of HAdV pneumonia and severe HAdV pneumonia. Receiver operating characteristic (ROC) curve analysis suggested that hsa_circ_0002171 had a significant value in the diagnosis of HAdV pneumonia and of severe HAdV pneumonia. No 36350973 hsa_circ_005970 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3647 No 31026505 hsa_circ_001993 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3646 No 31026505 mmu_circ_22546 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] qRT-PCR//Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 395 down-regulated circRNAs were identified. No 31692917 mmu_circ_43913 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 372 down-regulated circRNAs were identified. No 31692917 mmu_circ_014815 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 390 down-regulated circRNAs were identified. No 31692917 hsa_circ_0085616 CircRNA Homo sapiens Uterine Cervical Neoplasms Cervical Cancer tissues regulation[miR-503-5p-Mediated ATXN7L3 Activation] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ_0085616 was heightened and its downregulation blocked cellular proliferation, metastasis, and glycolysis in CC. It was obvious that circ_0085616 facilitated the carcinogenic effect on CC via the activation of ATXN7L3 by sponging miR-503-5p. No 33090006 circUSP42 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissue Expression[lower expressed] qRT-PCR circUSP42 Is Downregulated in Triple-Negative Breast Cancer and Associated With Poor Prognosis. circUSP42 Is Downregulated in Triple-Negative Breast Cancer and Associated With Poor Prognosis. No 32938310 mmu_circ_39099 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 380 down-regulated circRNAs were identified. No 31692917 hsa_circ_007187 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3580 No 31026505 hsa_circ_001935 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3581 No 31026505 hsa_circ_003639 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3630 No 31026505 circMYLK CircRNA Homo sapiens Uterine Cervical Neoplasms cell lines regulation[mTOR signaling] CCK8//qRT-PCR//Tunel//EdU Staining We disclosed that circMYLK was up-regulated in CC cell lines and acted as a sponge of miR-1301-3p. It was unveiled that circMYLK sponged miR-1301-3p to promote RHEB expression, which resulted in mTOR signaling activation and CC cell malignant growth. No 32547198 hsa_circ_001008 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3638 No 31026505 hsa_circ_0018289 CircRNA Homo sapiens Uterine Cervical Neoplasms tumor tissue Expression[highly expressed] qRT-PCR Circ_0018289 expression was upregulated in tumor tissue compared with paired adjacent tissue (P < .001), and receiver operative characteristic curve disclosed its good value for separating tumor tissue from adjacent tissue with an area under curve of 0.907 (95% CI: 0.879-0.935). Additionally, tumor circ_0018289 expression was positively associated with tumor size (P = .009), lymph node metastasis (P = .005) and Federation International of Gynecology and Obstetrics stage (P = .005). The DFS (P = .005) and OS (P = .015) were both worse in patients with circ_0018289 high expression compared to patients with circ_0018289 low expression. Meanwhile, in patients with circ_0018289 high expression, DFS and OS were the longest in patients with high+ expression followed by patients with high++ expression, and the shortest in patients with high+++ expression. No 32320103 mmu_circ_39100 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 382 down-regulated circRNAs were identified. No 31692917 mmu_circ_011865 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 381 down-regulated circRNAs were identified. No 31692917 hsa_circ_005707 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3637 No 31026505 mmu_circ_41991 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 389 down-regulated circRNAs were identified. No 31692917 mmu_circ_014393 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 379 down-regulated circRNAs were identified. No 31692917 mmu_circ_19175 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 376 down-regulated circRNAs were identified. No 31692917 mmu_circ_41990 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 378 down-regulated circRNAs were identified. No 31692917 hsa_circ_005543 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3636 No 31026505 hsa_circ_005837 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3635 No 31026505 hsa_circ_003929 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3634 No 31026505 hsa_circ_001716 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3633 No 31026505 hsa_circ_001304 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3632 No 31026505 hsa_circ_007290 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3639 No 31026505 hsa_circ_006914 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3640 No 31026505 hsa_circ_003266 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3641 No 31026505 hsa_circ_006336 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3642 No 31026505 mmu_circ_19241 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 388 down-regulated circRNAs were identified. No 31692917 hsa_circ_0001675 LncRNA Homo sapiens head and neck carcinoma HNC and adjacent normal tissues Regulation(hsa_circ_0001675-miRNA-mRNA axis.) qRT-PCR//IHC A total of 714 differentially expressed circRNAs were detected in HNC, and the low expression of hsa_circ_0001675 was particularly significant (fold change [FC] = -4.85, P = 6.305E-05). hsa_circ_0001675 had significantly lower expression in HNC than in normal tissue (P < 0.01). Low hsa_circ_0001675 expression was positively associated with tumor invasion and clinical staging (P < 0.05), and its area under the ROC curve (AUC) was 0.7776. Low hsa_circ_0001675 expression also correlated with the overall survival (OS) rate and the progression-free survival (PFS) rate of HNC patients (P < 0.001). Bioinformatics was used to construct a ceRNA network of hsa_circ_0001675 with six differentially expressed miRNAs (hsa-miR-330-5p, hsa-miR-498, hsa-miR-532-3p, hsa-miR-577, hsa-miR-1248, and hsa-miR-1305) and 411 differentially expressed mRNAs and found that the neuroactive ligand-receptor interaction, and the cAMP and calcium signaling pathways were particularly enriched. Further bioinformatics and IHC analysis showed that miR577/TESC is the likely downstream signaling pathway for hsa_circ_0001675. Low hsa_circ_0001675 expression was positively associated with tumor invasion and clinical staging (P < 0.05), and its area under the ROC curve (AUC) was 0.7776. Low hsa_circ_0001675 expression also correlated with the overall survival (OS) rate and the progression-free survival (PFS) rate of HNC patients (P < 0.001). No 35600372 mmu_circ_45453 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 387 down-regulated circRNAs were identified. No 31692917 circXPO5 CircRNA Homo sapiens Geniculate Bodies macaque glaucoma model Interaction(miR-330-5p) RNA-seq circXPO5 significantly decreased in the glaucoma model and a ceRNA network analysis revealed that circXPO5 can bind to miR-330-5p, which also binds to GRIN2A (ionotropic receptor NMDA type subunit 2A). QPCR detection showed a decrease in GRIN2A and an increase in miR-330-5p. No 35741665 mmu_circ_33363 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 386 down-regulated circRNAs were identified. No 31692917 hsa_circ_000047 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3644 No 31026505 hsa_circ_0072309 CircRNA Homo sapiens Glioblastoma GBM tissues and cells Interaction(p53) In Vivo Experiment//Western Blot//Flow Cytometry//IHC//IF Low hsa_circ_0072309 expression predicts poor prognosis for glioma patients. Hsa_circ_0072309 inhibits p53 ubiquitination and increases the stability of p53 protein in the context of p53 wild-type. MiR-100 mediates hsa_circ_0072309 regulating p53. P53 inhibitor or autophagy inhibitor could reverse the effect of hsa_circ_0072309 on TMZ sensitivity in p53 wild-type GBM. Low hsa_circ_0072309 expression predicts poor prognosis for glioma patients. No 35212145 mmu_circ_012434 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 374 down-regulated circRNAs were identified. No 31692917 mmu_circ_30196 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 385 down-regulated circRNAs were identified. No 31692917 mmu_circ_22265 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 384 down-regulated circRNAs were identified. No 31692917 mmu_circ_37328 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 375 down-regulated circRNAs were identified. No 31692917 hsa_circ_002033 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3567 No 31026505 hsa_circ_005122 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3568 No 31026505 hsa_circ_004320 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3579 No 31026505 mmu_circ_22646 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[lower expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 mmu_circ_25930 CircRNA Mus musculus Retinal Diseases retina tissues Expression[lower expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 383 down-regulated circRNAs were identified. No 31692917 hsa_circ_002903 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3643 No 31026505 hsa_circ_006204 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3576 No 31026505 circGARS CircRNA Homo sapiens Lupus Erythematosus, Systemic SLE patients Regulation(miR-19a /YTHDF2 /NF-κB/A20 axis) RNA Pull-Down//Western Blot//Transfection//qRT-PCR//RIP//FISH//Luciferase Report Assay Our results demonstrated that the levels of circGARS was remarkably upregulated in SLE and correlated with clinicopathological features. CircGARS directly combined with microRNA-19a (miR-19a). Functionally, circGARS downregulated the expression of TNFAIP3 (A20, tumor necrosis factor alpha-induced protein 3) to mediate the activation of immune responses that were regulated by the nuclear factor-κB (NF-κB) pathway as a negative feedback mechanism. In addition, miR-19a regulated A20 (TNFAIP3) degradation by downregulating the expression of YTH N6-methyladenosine RNA-binding protein 2 (YTHDF2). Our results demonstrated that the levels of circGARS was remarkably upregulated in SLE and correlated with clinicopathological features. No 35120571 hsa_circ_092369 CircRNA Homo sapiens Retinal Diseases peripheral blood mononuclear cells Regulation qRT-PCR//Bioinformatics Analysis//Microarray Three circRNAs (hsa_circRNA_061346, hsa_circRNA_092369, and hsa_circRNA_103554) were identified as potential diagnostic biomarkers for ROP with certain clinical values. No 36081509 hsa_circ_000056 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7330 No 31026505 mmu_circ_011180 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] qRT-PCR//Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 363 down-regulated circRNAs were identified. No 31692917 hsa_circ_000589 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3659 No 31026505 mmu_circ_35127 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[lower expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_003821 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3561 No 31026505 hsa_circ_0008301 CircRNA Homo sapiens Sjogren's Syndrome peripheral blood of pSS patients Expression(highly expressed) qRT-PCR//Western Blot The relative expression of hsa_circ_0008301 in the peripheral blood of pSS patients was significantly higher than that in the control groups including healthy control group and disease control group. No 36113315 hsa_circ_000467 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3658 No 31026505 hsa_circ_006409 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7328 No 31026505 hsa_circ_003268 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7329 No 31026505 hsa_circ_005315 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3562 No 31026505 mmu_circ_25277 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 361 down-regulated circRNAs were identified. No 31692917 mmu_circ_19534 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 364 down-regulated circRNAs were identified. No 31692917 hsa_circ_000268 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7331 No 31026505 hsa_circ_003986 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3563 No 31026505 hsa_circ_000381 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3564 No 31026505 hsa_circ_006461 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7332 No 31026505 mmu_circ_012082 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 365 down-regulated circRNAs were identified. No 31692917 hsa_circ_000364 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3565 No 31026505 hsa_circ_006965 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7333 No 31026505 mmu_circ_016108 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] qRT-PCR//Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 362 down-regulated circRNAs were identified. No 31692917 hsa_circ_004488 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3588 No 31026505 hsa_circ_006076 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3651 No 31026505 hsa_circ_002816 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3590 No 31026505 hsa_circ_006037 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7327 No 31026505 hsa_circ_001932 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3593 No 31026505 hsa_circ_000794 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3592 No 31026505 hsa_circ_002969 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3663 No 31026505 hsa_circ_103554 CircRNA Homo sapiens Retinal Diseases peripheral blood mononuclear cells Regulation qRT-PCR//Bioinformatics Analysis//Microarray Three circRNAs (hsa_circRNA_061346, hsa_circRNA_092369, and hsa_circRNA_103554) were identified as potential diagnostic biomarkers for ROP with certain clinical values. No 36081509 hsa_circ_002070 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3591 No 31026505 hsa_circ_003203 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3662 No 31026505 hsa_circ_001684 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3569 No 31026505 hsa_circ_002110 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3661 No 31026505 mmu_circ_32628 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 360 down-regulated circRNAs were identified. No 31692917 hsa_circ_0101622 CircRNA Homo sapiens Thyroid Neoplasms tumor tissues and plasma Expression[highly expressed] qRT-PCR Hsa_circ_0124055 and hsa_circ_0101622 as the most conspicuous biomarkers were significantly increased in tumor tissues and plasma of thyroid cancer patients. High hsa_circ_0124055 or hsa_circ_0101622 expression exhibited shorter overall survival. No 32373972 hsa_circ_0124055 CircRNA Homo sapiens Thyroid Neoplasms tumor tissues and plasma Expression[highly expressed] qRT-PCR Hsa_circ_0124055 and hsa_circ_0101622 as the most conspicuous biomarkers were significantly increased in tumor tissues and plasma of thyroid cancer patients. High hsa_circ_0124055 or hsa_circ_0101622 expression exhibited shorter overall survival. No 32373972 hsa_circ_006591 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3589 No 31026505 hsa_circ_000032 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3660 No 31026505 mmu_circ_28143 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[lower expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_0048122 CircRNA Homo sapiens Colorectal Neoplasms stage IV CRC patients Expression(highly expressed) qRT-PCR A strong correlation between liver metastases and hsa_circ_0048122 expression in stage IV CRC patients with a high hsa_circ_0048122 profile indicated a poor overall survival. Likewise, a high expression level of hsa_circ_0048122 appears as a potential predictor of liver metastases in patients' initial stages. A strong correlation between liver metastases and hsa_circ_0048122 expression in stage IV CRC patients with a high hsa_circ_0048122 profile indicated a poor overall survival. No 35792043 hsa_circ_001717 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3631 No 31026505 mmu_circ_24234 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 366 down-regulated circRNAs were identified. No 31692917 hsa_circ_004314 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7334 No 31026505 hsa_circ_0055202 CircRNA Homo sapiens Glioblastoma plasma of GBM patients and healthy volunteers Regulation Cell Proliferation Assay//qRT-PCR//Transwell Assay Five circRNAs were first selected as candidates with the upregulated level in exosome isolated from the plasma of GBM. Further validation found that only hsa_circ_0055202, hsa_circ_0074920 and hsa_circ_0043722 were consistent with training set. No 34385405 hsa_circ_001045 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3584 No 31026505 circDOCK1 CircRNA Homo sapiens Thyroid Neoplasms thyroid carcinoma tissues regulation[JAK/STAT/AMPK] qRT-PCR//Western Blot Results from qRT-PCR showed circDOCK1 was enriched in thyroid carcinoma tissues. circDOCK1 contributed to thyroid carcinogenesis through inhibition of miR-124 in thyroid cancer cells with dampening signaling transduction of JAK/STAT/AMPK in virtue of miR-124 downregulation. No 32584497 hsa_circ_005142 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3620 No 31026505 hsa_circ_000414 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3621 No 31026505 hsa_circ_003677 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3622 No 31026505 hsa_circ_002380 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3623 No 31026505 hsa_circ_000380 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3624 No 31026505 hsa_circ_004185 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3657 No 31026505 hsa_circ_002693 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3656 No 31026505 mmu_circ_19159 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 368 down-regulated circRNAs were identified. No 31692917 hsa_circ_0003416 CircRNA Homo sapiens Pulmonary Arterial Hypertension plasma Expression(lower expressed) qRT-PCR//Bioinformatics Analysis Expression levels of hsa_circ_0003416 in plasma were lower in the PAH-CHD group than in the CHD and healthy control groups (p = 0.009 vs. healthy control group, p = 0.026 vs. CHD group). Moreover, hsa_circ_0003416 was found to be negatively associated with B-type natriuretic peptide (r = -0.342, p = 0.013). In addition, the area under the curve of hsa_circ_0003416 levels in plasma was 0.721 (95% confidence intervals = 0.585-0.857, p = 0.004), suggesting that it has a promising diagnostic value. No 35165927 hsa_circ_002400 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3655 No 31026505 hsa_circ_005410 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3654 No 31026505 hsa_circ_0001831 CircRNA Homo sapiens Diabetic Nephropathies T2DM patients Expression(highly expressed) qRT-PCR//Microarray qRT-PCR results revealed that hsa_circ_0001831 and hsa_circ_0000867 were significantly upregulated in ET2DN group compared to both of T2DM and control group. The ROC curve demonstrated that hsa_circ_0001831 and hsa_circ_0000867 have high sensitivity and specificity associated with ET2DN. No 36118796 hsa_circ_001217 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3653 No 31026505 hsa_circ_000271 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3575 No 31026505 hsa_circ_001868 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3652 No 31026505 circPTPN22 CircRNA Homo sapiens Cholangiocarcinoma tumor tissues and plasma exosomes of Asian patients with ICC Expression(highly expressed) qRT-PCR//RNA-seq The levels of circ-PTPN22 (hsa_circ_0110529) and circ-ADAMTS6 (hsa_circ_0072688), potential circRNA biomarkers, were elevated in the ICC tumor tissues and plasma exosomes of this subgroup than in the other subgroups and normal controls. Our results revealed a subgroup of Asian ICC characterized by T cell exhaustion and neutrophil extracellular traps and marked by elevated levels of circ-PTPN22 and circ-ADAMTS6 in tumor tissues and plasma exosomes. No 36700045 mmu_circ_28144 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[lower expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_0008193 CircRNA Homo sapiens autoimmune thyroiditis plasma of HT Expression(highly expressed) qRT-PCR//Bioinformatics Analysis//Microarray Notably, hsa_circ_0008193 verified by RT-qPCR were the major upregulation circRNAs involved in the chemokine signaling pathway. No 35064448 mmu_circ_45155 CircRNA Mus musculus Retinal Diseases retina tissues Expression[highly expressed] Microarray Microarray analysis revealed that 539 circRNAs were significantly altered in OIR retinas compared with controls. Among them, 185 up-regulated and 367 down-regulated circRNAs were identified. No 31692917 hsa_circ_001864 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3619 No 31026505 hsa_circ_000748 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3618 No 31026505 mmu_circ_004372 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[highly expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 mmu_circ_21487 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[lower expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_005231 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3587 No 31026505 hsa_circ_0000867 CircRNA Homo sapiens Diabetic Nephropathies T2DM patients Expression(highly expressed) qRT-PCR//Microarray qRT-PCR results revealed that hsa_circ_0001831 and hsa_circ_0000867 were significantly upregulated in ET2DN group compared to both of T2DM and control group. The ROC curve demonstrated that hsa_circ_0001831 and hsa_circ_0000867 have high sensitivity and specificity associated with ET2DN. No 36118796 hsa_circ_000654 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7335 No 31026505 hsa_circ_0074920 CircRNA Homo sapiens Glioblastoma plasma of GBM patients and healthy volunteers Regulation Cell Proliferation Assay//qRT-PCR//Transwell Assay Five circRNAs were first selected as candidates with the upregulated level in exosome isolated from the plasma of GBM. Further validation found that only hsa_circ_0055202, hsa_circ_0074920 and hsa_circ_0043722 were consistent with training set. No 34385405 hsa_circ_0007990 CircRNA Homo sapiens Intracranial Aneurysm peripheral blood samples Expression(highly expressed) qRT-PCR//Microarray The expression of hsa_circ_0007990 was increased gradually in the healthy control, UIA without AWE, and UIA with AWE confirmed by RT-PCR (P<0.001). No 36466848 hsa_circ_006756 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3615 No 31026505 hsa_circ_005847 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3586 No 31026505 hsa_circ_000294 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7336 No 31026505 hsa_circ_0043722 CircRNA Homo sapiens Glioblastoma plasma of GBM patients and healthy volunteers Regulation Cell Proliferation Assay//qRT-PCR//Transwell Assay Five circRNAs were first selected as candidates with the upregulated level in exosome isolated from the plasma of GBM. Further validation found that only hsa_circ_0055202, hsa_circ_0074920 and hsa_circ_0043722 were consistent with training set. No 34385405 hsa_circ_000703 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3616 No 31026505 hsa_circ_002239 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3617 No 31026505 hsa_circ_005496 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3566 No 31026505 hsa_circ_000967 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7337 No 31026505 hsa_circ_005644 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3585 No 31026505 hsa_circ_004510 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3574 No 31026505 hsa_circ_000345 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3648 No 31026505 hsa_circ_001285 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7183 No 31026505 hsa_circ_005221 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7297 No 31026505 hsa_circ_001686 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3873 No 31026505 hsa_circ_002557 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3889 No 31026505 hsa_circ_007293 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3888 No 31026505 hsa_circ_004110 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3887 No 31026505 hsa_circ_003520 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3886 No 31026505 hsa_circ_002203 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3885 No 31026505 hsa_circ_003076 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3884 No 31026505 hsa_circ_002862 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3883 No 31026505 hsa_circ_001996 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3882 No 31026505 hsa_circ_004722 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3881 No 31026505 hsa_circ_006042 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3880 No 31026505 hsa_circ_001556 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3879 No 31026505 hsa_circ_002334 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3878 No 31026505 hsa_circ_004711 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3877 No 31026505 hsa_circ_002166 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3876 No 31026505 hsa_circ_003629 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3875 No 31026505 hsa_circ_000342 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3890 No 31026505 hsa_circ_001749 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3891 No 31026505 hsa_circ_004713 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3892 No 31026505 hsa_circ_005414 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3899 No 31026505 hsa_circ_0009109 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0069190 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0076822 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0039007 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0076085 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_003308 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3900 No 31026505 hsa_circ_007303 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3898 No 31026505 hsa_circ_0010276 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005863 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3897 No 31026505 hsa_circ_002137 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3896 No 31026505 hsa_circ_002103 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3895 No 31026505 hsa_circ_003580 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3894 No 31026505 hsa_circ_000416 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3893 No 31026505 hsa_circ_0073803 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_003900 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3874 No 31026505 hsa_circ_0016299 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0000490 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0079791 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004426 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3871 No 31026505 hsa_circ_0033068 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0088351 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0004966 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0060796 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0007218 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0056701 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0008651 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0009446 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0043021 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0079944 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0003735 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0025769 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_006174 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3870 No 31026505 hsa_circ_0049425 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0066583 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0002674 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0011136 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0002310 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0003561 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0055428 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0033530 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0037149 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0036587 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0027828 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0057879 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0074801 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0058680 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0055362 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0047581 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0031834 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_002617 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3872 No 31026505 hsa_circ_0014232 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0018762 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0014690 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0075189 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005157 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3907 No 31026505 hsa_circ_0001162 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0014809 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0061564 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0082634 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0031939 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0077055 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0005301 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_000750 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3911 No 31026505 hsa_circ_002169 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3910 No 31026505 hsa_circ_003130 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3909 No 31026505 hsa_circ_0056286 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_002069 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3908 No 31026505 hsa_circ_0043147 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0082796 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0004564 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_006263 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3912 No 31026505 hsa_circ_003727 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3913 No 31026505 hsa_circ_0032492 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0071474 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0015792 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0075801 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0071423 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0077301 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0057588 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0001459 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0008009 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0011612 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0058754 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0031868 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0015166 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0006751 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0020164 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0067007 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0028204 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0040483 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0080024 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_001661 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3906 No 31026505 hsa_circ_0068493 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_001204 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3902 No 31026505 hsa_circ_0020375 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005135 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3901 No 31026505 hsa_circ_0061640 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0026441 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0081670 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0007943 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0057880 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0006725 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0013526 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0078718 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0080344 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0041203 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0026889 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0071884 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005791 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3903 No 31026505 hsa_circ_002104 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3904 No 31026505 hsa_circ_0041475 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0044090 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0073776 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0002912 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0048159 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004104 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3905 No 31026505 hsa_circ_0047582 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0089074 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0000661 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0089903 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0058473 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0042347 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0006996 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0065164 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0041843 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0087909 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0046139 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0069528 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004847 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6925 No 31026505 hsa_circ_004546 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3836 No 31026505 hsa_circ_0051674 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_002002 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6913 No 31026505 hsa_circ_0042884 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_006926 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6914 No 31026505 hsa_circ_002003 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6915 No 31026505 hsa_circ_006507 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6916 No 31026505 hsa_circ_002309 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6917 No 31026505 hsa_circ_002755 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6918 No 31026505 hsa_circ_001372 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6919 No 31026505 hsa_circ_007272 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6920 No 31026505 hsa_circ_000301 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6921 No 31026505 hsa_circ_005930 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6922 No 31026505 hsa_circ_0001460 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_000241 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6923 No 31026505 hsa_circ_003178 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6912 No 31026505 circCNTN6 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 circCRTAM CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_007097 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6906 No 31026505 hsa_circ_000997 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3837 No 31026505 hsa_circ_006585 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6905 No 31026505 hsa_circ_0005512 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0077302 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0002184 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0043886 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004226 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6907 No 31026505 hsa_circ_006066 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6911 No 31026505 hsa_circ_0055275 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_001871 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6908 No 31026505 hsa_circ_005447 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6909 No 31026505 hsa_circ_0027258 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_006381 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6910 No 31026505 hsa_circ_0075782 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_006610 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6924 No 31026505 hsa_circ_0070256 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0041793 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0029708 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_001921 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6930 No 31026505 hsa_circ_005395 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6931 No 31026505 hsa_circ_0048880 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_002417 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6932 No 31026505 hsa_circ_005397 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6933 No 31026505 hsa_circ_0054314 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005403 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6934 No 31026505 hsa_circ_002949 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6935 No 31026505 hsa_circ_002576 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6936 No 31026505 hsa_circ_002902 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6937 No 31026505 hsa_circ_000379 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6938 No 31026505 hsa_circ_000910 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6939 No 31026505 hsa_circ_004820 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6940 No 31026505 hsa_circ_005731 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6941 No 31026505 hsa_circ_0026421 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0069307 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0062859 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0086717 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0015056 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_001689 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6926 No 31026505 hsa_circ_0064611 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0047503 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0017384 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0012844 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0086723 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0032821 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_007130 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6929 No 31026505 hsa_circ_0046816 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_003439 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3835 No 31026505 hsa_circ_0084896 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_003214 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6927 No 31026505 hsa_circ_002329 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6928 No 31026505 hsa_circ_0027655 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0049854 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_002391 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6904 No 31026505 hsa_circ_0084934 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0048158 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_006394 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3853 No 31026505 hsa_circ_002983 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3852 No 31026505 hsa_circ_004813 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3851 No 31026505 hsa_circ_000881 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3850 No 31026505 hsa_circ_005752 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3849 No 31026505 hsa_circ_006122 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3848 No 31026505 hsa_circ_004265 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3847 No 31026505 hsa_circ_007277 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3846 No 31026505 hsa_circ_003584 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3845 No 31026505 hsa_circ_0053587 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0001799 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0082391 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0006936 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0067800 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0092301 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005260 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3854 No 31026505 hsa_circ_006276 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3855 No 31026505 hsa_circ_005255 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3856 No 31026505 hsa_circ_006470 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3865 No 31026505 hsa_circ_003059 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3869 No 31026505 hsa_circ_0026609 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004472 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3868 No 31026505 hsa_circ_0026158 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_000360 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3867 No 31026505 hsa_circ_004882 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3866 No 31026505 hsa_circ_002228 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3864 No 31026505 hsa_circ_001794 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3857 No 31026505 hsa_circ_002604 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3863 No 31026505 hsa_circ_007176 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3862 No 31026505 hsa_circ_003357 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3861 No 31026505 hsa_circ_002157 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3860 No 31026505 hsa_circ_000375 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3859 No 31026505 hsa_circ_006184 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3858 No 31026505 hsa_circ_0041200 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0013780 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0088884 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0038587 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_000705 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6899 No 31026505 hsa_circ_000149 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6900 No 31026505 hsa_circ_001590 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6901 No 31026505 hsa_circ_005610 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3843 No 31026505 hsa_circ_002917 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3842 No 31026505 hsa_circ_001685 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3841 No 31026505 hsa_circ_000758 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3840 No 31026505 hsa_circ_005278 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3839 No 31026505 hsa_circ_002818 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3838 No 31026505 hsa_circ_0043599 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0027176 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_006516 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6902 No 31026505 hsa_circ_0035851 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_000119 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6903 No 31026505 hsa_circ_0045494 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_001123 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6898 No 31026505 hsa_circ_0047422 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_003113 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6897 No 31026505 hsa_circ_0021111 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0047330 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0004560 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0030123 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0029697 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0048151 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0017672 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0071817 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_006352 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6896 No 31026505 hsa_circ_0000903 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004157 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6892 No 31026505 hsa_circ_004888 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6893 No 31026505 hsa_circ_001761 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6894 No 31026505 hsa_circ_001747 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3844 No 31026505 hsa_circ_000365 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6895 No 31026505 hsa_circ_0014221 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0002091 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004833 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7296 No 31026505 hsa_circ_0069475 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_002287 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3967 No 31026505 hsa_circ_004501 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3966 No 31026505 hsa_circ_0062960 LncRNA Homo sapiens Heart Failure plasma Expression[highly expressed] qRT-PCR//Microarray Among the dysregulated circRNAs, hsa_circ_0112085 (p = 0.0032), hsa_circ_0062960 (p = 0.0006), hsa_circ_0053919 (p = 0.0074) and hsa_circ_0014010 (p = 0.025) showed significantly higher expression in patients with HF compared with healthy controls. No 31991759 hsa_circ_0053919 LncRNA Homo sapiens Heart Failure plasma Expression[highly expressed] qRT-PCR//Microarray Among the dysregulated circRNAs, hsa_circ_0112085 (p = 0.0032), hsa_circ_0062960 (p = 0.0006), hsa_circ_0053919 (p = 0.0074) and hsa_circ_0014010 (p = 0.025) showed significantly higher expression in patients with HF compared with healthy controls. No 31991759 hsa_circ_0014010 LncRNA Homo sapiens Heart Failure plasma Expression[highly expressed] qRT-PCR//Microarray Among the dysregulated circRNAs, hsa_circ_0112085 (p = 0.0032), hsa_circ_0062960 (p = 0.0006), hsa_circ_0053919 (p = 0.0074) and hsa_circ_0014010 (p = 0.025) showed significantly higher expression in patients with HF compared with healthy controls. No 31991759 hsa_circ_000689 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6885 No 31026505 hsa_circ_003400 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3965 No 31026505 hsa_circ_004502 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3964 No 31026505 hsa_circ_000744 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3963 No 31026505 hsa_circ_006459 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6886 No 31026505 hsa_circ_002897 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6887 No 31026505 hsa_circ_002233 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6888 No 31026505 hsa_circ_003483 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3962 No 31026505 hsa_circ_005456 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6889 No 31026505 hsa_circ_0071253 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_000618 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3968 No 31026505 hsa_circ_002005 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3969 No 31026505 hsa_circ_004263 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3970 No 31026505 hsa_circ_002633 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3979 No 31026505 hsa_circ_006073 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3985 No 31026505 hsa_circ_005572 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3984 No 31026505 hsa_circ_006583 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3983 No 31026505 hsa_circ_004517 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3982 No 31026505 hsa_circ_001253 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3981 No 31026505 hsa_circ_004416 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3980 No 31026505 hsa_circ_005421 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3978 No 31026505 hsa_circ_005201 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3971 No 31026505 hsa_circ_003152 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3977 No 31026505 hsa_circ_005296 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3976 No 31026505 hsa_circ_003608 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3975 No 31026505 hsa_circ_006131 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3974 No 31026505 hsa_circ_000925 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3973 No 31026505 hsa_circ_002488 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3972 No 31026505 hsa_circ_0025770 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0087115 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005501 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3987 No 31026505 hsa_circ_0069478 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004401 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3951 No 31026505 hsa_circ_001576 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3950 No 31026505 hsa_circ_002543 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3949 No 31026505 hsa_circ_006547 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3948 No 31026505 hsa_circ_003621 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3947 No 31026505 hsa_circ_005719 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3946 No 31026505 hsa_circ_0041204 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004646 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3945 No 31026505 hsa_circ_0087116 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005152 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3944 No 31026505 hsa_circ_0008002 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0087097 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0004390 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0071487 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0000512 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004588 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3952 No 31026505 hsa_circ_000334 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3953 No 31026505 hsa_circ_005186 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3954 No 31026505 hsa_circ_006876 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6890 No 31026505 hsa_circ_004339 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3961 No 31026505 hsa_circ_0004987 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_003802 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3960 No 31026505 hsa_circ_0078574 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0091587 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_001907 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3959 No 31026505 hsa_circ_001739 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6891 No 31026505 hsa_circ_001766 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3955 No 31026505 hsa_circ_0025765 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005349 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3958 No 31026505 hsa_circ_001125 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3957 No 31026505 hsa_circ_0087109 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_003894 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3956 No 31026505 hsa_circ_0018494 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_000308 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3986 No 31026505 hsa_circ_001219 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3988 No 31026505 hsa_circ_0014222 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0112085 LncRNA Homo sapiens Heart Failure plasma Expression[highly expressed] qRT-PCR//Microarray Among the dysregulated circRNAs, hsa_circ_0112085 (p = 0.0032), hsa_circ_0062960 (p = 0.0006), hsa_circ_0053919 (p = 0.0074) and hsa_circ_0014010 (p = 0.025) showed significantly higher expression in patients with HF compared with healthy controls. No 31991759 hsa_circ_000698 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4032 No 31026505 hsa_circ_001028 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6881 No 31026505 hsa_circ_002109 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6882 No 31026505 hsa_circ_004470 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4031 No 31026505 circEHBP1 CircRNA Homo sapiens acute myeloid leukemia AML patients Expression(highly expressed) RNA Pull-Down//Transfection//Flow Cytometry//qRT-PCR//MTT Compared to the controls, AML patients exhibited increased circEHBP1 and premature miR-129 levels but decreased mature miR-129 levels. No 36119459 hsa_circ_001120 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4030 No 31026505 hsa_circ_001214 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4029 No 31026505 hsa_circ_004885 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4028 No 31026505 hsa_circ_002935 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6883 No 31026505 hsa_circ_001264 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4027 No 31026505 hsa_circ_002529 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4026 No 31026505 hsa_circ_0089153 CircRNA Homo sapiens Ameloblastoma Biopsies of solid/multicystic AB and adjacent non-tumor tissues Interaction(miR-608/EGFR p53 axis) qRT-PCR//Transfection//Microarray Six differentially expressed circRNAs were selected and validated. According to miRNAs and pathways predicted, six correlated miRNAs were selected, hsa-miR-608 was filtered and validated. The hsa_circ_0089153/hsa-miR-608 binding sponge was validated. No 33523578 hsa_circ_0001667 CircRNA Homo sapiens Ameloblastoma Biopsies of solid/multicystic AB and adjacent non-tumor tissues Expression [lower expressed] qRT-PCR//Microarray Based on the circRNA microarray results and circRNA function prediction, six circRNAs (hsa_circ_0089153, hsa_circ_0001955, hsa_circ_0000517, hsa_circ_0080425, hsa_circ_0001667, hsa_circ_0043278), two of which were downregulated (hsa_circ_0001667, hsa_circ_0043278), were selected for quantitative validation. No 33523578 hsa_circ_004349 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4025 No 31026505 hsa_circ_0043278 CircRNA Homo sapiens Ameloblastoma Biopsies of solid/multicystic AB and adjacent non-tumor tissues Expression [lower expressed] qRT-PCR//Microarray Based on the circRNA microarray results and circRNA function prediction, six circRNAs (hsa_circ_0089153, hsa_circ_0001955, hsa_circ_0000517, hsa_circ_0080425, hsa_circ_0001667, hsa_circ_0043278), two of which were downregulated (hsa_circ_0001667, hsa_circ_0043278), were selected for quantitative validation. No 33523578 hsa_circ_002791 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4033 No 31026505 hsa_circ_0004812 CircRNA Homo sapiens Hepatitis B, Chronic liver tissues regulation[FSTL1,miR-1287-5p] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//Western Blot Levels of circ_0004812 were upregulated in CHB patients and HBV-infected hepatoma cells.Circ_0004812 was identified as a potential target for CHB infection. Circ_0004812 promoted the expression of FSTL1 by inhibiting miR-1287-5p. No 32188476 hsa_circ_006918 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6880 No 31026505 hsa_circ_004751 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4036 No 31026505 circGCN1L1 CircRNA Homo sapiens Osteoarthritis synoviocyte interaction[miR-330-3p and TNF-α ] qRT-PCR//Luciferase Report Assay//FISH The differentially upregulated circGCN1L1 (hsa_circ_0000448) in synoviocyte was validated in vitro and in vivo.Altogether, we elucidated the important roles of a novel circRNA, namely, circGCN1L1, which induced inflammation in TMJ synoviocytes and decreased anabolism of the extracellular matrix (ECM) through miR-330-3p and TNF-α gene. No 32332704 circHIPK3 CircRNA Homo sapiens Pancreatitis serum regulation[miR-193a-5p/GSDMD Axis] Western Blot//Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay//ELISA We found that the expression of circHIPK3 was significantly elevated in serum of patients with AP and in caerulein-stimulated AR42J cells and was associated with caspase-1 and caspase-11 activation.In conclusion, circHIPK3 promotes pyroptosis in acinar cells through regulation of the miR-193a-5p/GSDMD axis, which eventually aggravates AP disease. No 32318575 hsa_circ_002913 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4038 No 31026505 hsa_circ_002532 CircRNA Homo sapiens Pancreatitis blood Expression[lower expressed] qPCR//Microarray Next, the qPCR verification results further confirmed three downregulated circRNAs, including hsa_circRNA_002532, has_circRNA_059665, and hsa_circRNA_104156, and three upregulated circRNAs including hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470. No 32149089 hsa_circ_004587 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4037 No 31026505 hsa_circ_059665 CircRNA Homo sapiens Pancreatitis blood Expression[lower expressed] qPCR//Microarray Next, the qPCR verification results further confirmed three downregulated circRNAs, including hsa_circRNA_002532, has_circRNA_059665, and hsa_circRNA_104156, and three upregulated circRNAs including hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470. No 32149089 hsa_circ_104156 CircRNA Homo sapiens Pancreatitis blood Expression[lower expressed] qPCR//Microarray Next, the qPCR verification results further confirmed three downregulated circRNAs, including hsa_circRNA_002532, has_circRNA_059665, and hsa_circRNA_104156, and three upregulated circRNAs including hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470. No 32149089 hsa_circ_001908 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6879 No 31026505 hsa_circ_101015 CircRNA Homo sapiens Pancreatitis blood Expression[highly expressed] qPCR//Microarray Next, the qPCR verification results further confirmed three downregulated circRNAs, including hsa_circRNA_002532, has_circRNA_059665, and hsa_circRNA_104156, and three upregulated circRNAs including hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470. No 32149089 hsa_circ_101211 CircRNA Homo sapiens Pancreatitis blood Expression[highly expressed] qPCR//Microarray Next, the qPCR verification results further confirmed three downregulated circRNAs, including hsa_circRNA_002532, has_circRNA_059665, and hsa_circRNA_104156, and three upregulated circRNAs including hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470. No 32149089 hsa_circ_103470 CircRNA Homo sapiens Pancreatitis blood Expression[highly expressed] qPCR//Microarray Next, the qPCR verification results further confirmed three downregulated circRNAs, including hsa_circRNA_002532, has_circRNA_059665, and hsa_circRNA_104156, and three upregulated circRNAs including hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470. No 32149089 hsa_circ_004312 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4035 No 31026505 hsa_circ_004118 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4034 No 31026505 circFoxO3a CircRNA Homo sapiens Uterine Cervical Neoplasms serum Expression[lower expressed] qRT-PCR Levels of serum circFoxO3a were decreased in SCC patients compared with controls. Low expression of circFoxO3a was correlated with deeper stromal invasion and positive lymph node metastasis. Moreover, SCC patients with lower expression of serum circFoxO3a showed poorer prognosis, including both overall survival (OS) and recurrence-free survival (RFS). No 32308490 hsa_circ_007294 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6884 No 31026505 hsa_circ_005509 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4024 No 31026505 hsa_circ_005309 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3989 No 31026505 hsa_circ_005398 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4023 No 31026505 hsa_circ_005357 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4004 No 31026505 hsa_circ_003133 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4003 No 31026505 hsa_circ_003403 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4002 No 31026505 hsa_circ_006867 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4001 No 31026505 hsa_circ_004562 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4000 No 31026505 hsa_circ_004706 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3999 No 31026505 hsa_circ_007288 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3998 No 31026505 hsa_circ_001484 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3997 No 31026505 hsa_circ_001906 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3996 No 31026505 hsa_circ_001580 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3995 No 31026505 hsa_circ_005241 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3994 No 31026505 hsa_circ_004483 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3993 No 31026505 hsa_circ_001154 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3992 No 31026505 hsa_circ_004285 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3991 No 31026505 hsa_circ_005620 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3990 No 31026505 hsa_circ_004299 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4005 No 31026505 hsa_circ_005893 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4006 No 31026505 hsa_circ_006485 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4007 No 31026505 hsa_circ_005204 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4016 No 31026505 hsa_circ_002624 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4022 No 31026505 hsa_circ_005088 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4021 No 31026505 hsa_circ_003171 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4020 No 31026505 hsa_circ_004691 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4019 No 31026505 hsa_circ_000596 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4018 No 31026505 hsa_circ_003052 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4017 No 31026505 hsa_circ_005250 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4015 No 31026505 hsa_circ_003039 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4008 No 31026505 hsa_circ_004425 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4014 No 31026505 hsa_circ_002220 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4013 No 31026505 hsa_circ_002402 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4012 No 31026505 hsa_circ_000946 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4011 No 31026505 hsa_circ_002403 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4010 No 31026505 hsa_circ_000560 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4009 No 31026505 hsa_circ_0076380 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_003016 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3943 No 31026505 hsa_circ_0001761 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0067006 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005590 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3922 No 31026505 hsa_circ_0001192 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0087112 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0063430 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0052502 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0070447 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0000023 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0045578 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0052513 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0052508 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0008847 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0028638 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0001762 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0001764 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0032912 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_002199 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3923 No 31026505 hsa_circ_002411 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3924 No 31026505 hsa_circ_001013 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3925 No 31026505 hsa_circ_0080835 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0085178 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0000973 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0087231 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0051195 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0056898 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0003893 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0005079 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0006653 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0055280 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0052503 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0073792 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0071882 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0004530 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0077987 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0022673 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0068658 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0073446 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0052506 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_007269 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3917 No 31026505 hsa_circ_0052505 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_001231 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3916 No 31026505 hsa_circ_0071037 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0068494 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0001760 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_003917 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3915 No 31026505 hsa_circ_0010988 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0084293 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0071544 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0033522 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0085539 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_006519 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3914 No 31026505 hsa_circ_0082795 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0001258 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_006106 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3918 No 31026505 hsa_circ_006841 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3919 No 31026505 hsa_circ_0073777 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0022106 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0069658 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005098 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3921 No 31026505 hsa_circ_0058320 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0047835 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0071525 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0038222 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0003106 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_006200 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3920 No 31026505 hsa_circ_0087102 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0006664 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0001763 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0084270 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0087333 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0056702 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0005720 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0000972 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005540 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3942 No 31026505 hsa_circ_0087103 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0006041 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0001550 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0031787 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_000575 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3936 No 31026505 hsa_circ_0087110 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_000382 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3935 No 31026505 hsa_circ_0013781 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0073780 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0007672 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0026594 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0063012 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0077572 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0025210 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0038225 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_000090 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3934 No 31026505 hsa_circ_0032411 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0056794 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0087114 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0087100 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_002467 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3941 No 31026505 hsa_circ_0025764 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0000513 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0013594 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_000745 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3940 No 31026505 hsa_circ_004396 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3939 No 31026505 hsa_circ_0000514 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0082635 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0000511 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005619 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3938 No 31026505 hsa_circ_0006853 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0087111 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0087104 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005818 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3937 No 31026505 hsa_circ_005745 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3933 No 31026505 hsa_circ_0087096 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004447 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3926 No 31026505 hsa_circ_0002703 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0000519 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005429 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3930 No 31026505 hsa_circ_0014220 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0084873 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0042987 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0077765 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0080834 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0027392 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_002470 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3929 No 31026505 hsa_circ_0006997 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0000095 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0007334 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_002603 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3928 No 31026505 hsa_circ_0030167 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004521 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3927 No 31026505 hsa_circ_0000515 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0002238 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0011025 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0035229 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0016525 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0000518 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0077770 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0000520 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0087098 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_007278 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3932 No 31026505 hsa_circ_0031784 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0071478 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0055902 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0087101 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0001137 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0079308 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0014090 CircRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_006426 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3931 No 31026505 hsa_circ_003868 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6942 No 31026505 hsa_circ_001865 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3834 No 31026505 hsa_circ_005958 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3833 No 31026505 hsa_circ_004726 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7151 No 31026505 hsa_circ_000791 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3714 No 31026505 hsa_circ_005956 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7136 No 31026505 hsa_circ_006574 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7137 No 31026505 hsa_circ_005570 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7138 No 31026505 hsa_circ_000290 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7139 No 31026505 hsa_circ_003758 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7140 No 31026505 hsa_circ_006814 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7141 No 31026505 hsa_circ_000208 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7142 No 31026505 hsa_circ_001511 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7143 No 31026505 hsa_circ_002761 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7144 No 31026505 hsa_circ_001160 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7145 No 31026505 hsa_circ_003554 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7146 No 31026505 hsa_circ_000511 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7147 No 31026505 hsa_circ_007013 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7148 No 31026505 hsa_circ_001025 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7149 No 31026505 hsa_circ_004526 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3715 No 31026505 hsa_circ_006430 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3716 No 31026505 hsa_circ_000902 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7135 No 31026505 circRIP2 CircRNA Homo sapiens lung non-small cell carcinoma NSCLC tissues, as well as cell lines Interaction(miR-671-5p/FOXM1) RNA Pull-Down//CCK8//RIP//Luciferase Report Assay//BrdU//Transwell Assay We showed circRIP2 is differentially expressed NSCLC, and acted as a predictor for overall survival (OS) and disease-free survival (DFS). CircRIP2 promoted NSCLC progression by acting as a miRNA sponge for miR-671-5p, thus facilitating its target gene FOXM1 expression. Targeting circRIP2 could be potentially beneficial for NSCLC patients in the future. We showed circRIP2 is differentially expressed NSCLC, and acted as a predictor for overall survival (OS) and disease-free survival (DFS). No 34291441 hsa_circ_000742 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3725 No 31026505 hsa_circ_003547 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3724 No 31026505 hsa_circ_003827 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3723 No 31026505 hsa_circ_006093 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3722 No 31026505 hsa_circ_005672 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3721 No 31026505 hsa_circ_000563 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7130 No 31026505 hsa_circ_003822 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7131 No 31026505 hsa_circ_005725 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7134 No 31026505 hsa_circ_001928 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7132 No 31026505 hsa_circ_000237 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3720 No 31026505 hsa_circ_002750 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7133 No 31026505 hsa_circ_005973 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3719 No 31026505 hsa_circ_001720 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3718 No 31026505 hsa_circ_006058 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3717 No 31026505 hsa_circ_006581 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7150 No 31026505 hsa_circ_005169 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7152 No 31026505 hsa_circ_003927 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3727 No 31026505 hsa_circ_002086 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7153 No 31026505 hsa_circ_0043837 CircRNA Homo sapiens Stroke exosomal Regulation qRT-PCR//circRNA-seq//Western Blot Using exosomal circRNA sequencing, large sample validation, and diagnostic model construction revealed that exosomal circ_0043837 and circ_ 0001801were independent predictive factors for LAA stroke, and had better diagnostic efficacy than plasma circRNAs. No 35095932 hsa_circ_001823 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7169 No 31026505 hsa_circ_000348 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3710 No 31026505 hsa_circ_007164 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7170 No 31026505 hsa_circ_002834 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7171 No 31026505 hsa_circ_005796 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7172 No 31026505 hsa_circ_004809 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7173 No 31026505 hsa_circ_003995 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7174 No 31026505 hsa_circ_002306 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7175 No 31026505 hsa_circ_002709 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7176 No 31026505 hsa_circ_006959 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7177 No 31026505 hsa_circ_000420 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7178 No 31026505 hsa_circ_005675 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7179 No 31026505 hsa_circ_003542 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7180 No 31026505 hsa_circ_006343 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7181 No 31026505 hsa_circ_002630 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7168 No 31026505 hsa_circ_003296 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7167 No 31026505 hsa_circ_002838 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7166 No 31026505 hsa_circ_000067 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7158 No 31026505 hsa_circ_000931 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7154 No 31026505 hsa_circ_001529 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3713 No 31026505 hsa_circ_000264 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7155 No 31026505 hsa_circ_005573 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3712 No 31026505 hsa_circ_006886 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7156 No 31026505 hsa_circ_001727 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7157 No 31026505 hsa_circ_003253 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7159 No 31026505 hsa_circ_003575 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7165 No 31026505 hsa_circ_001490 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3711 No 31026505 hsa_circ_005942 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7160 No 31026505 hsa_circ_004133 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7161 No 31026505 hsa_circ_006598 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7162 No 31026505 hsa_circ_001354 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7163 No 31026505 hsa_circ_002537 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7164 No 31026505 hsa_circ_003003 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3726 No 31026505 hsa_circ_004763 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7129 No 31026505 hsa_circ_005190 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3536 No 31026505 hsa_circ_004597 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3751 No 31026505 hsa_circ_003651 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3764 No 31026505 hsa_circ_007002 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3763 No 31026505 hsa_circ_003529 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3762 No 31026505 hsa_circ_006635 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7115 No 31026505 hsa_circ_000681 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7116 No 31026505 hsa_circ_0000437 CircRNA Homo sapiens Endometrial Neoplasms human endometrial cancer (EC) samples Expression [lower expressed] In Vivo Experiment//Northern Blot//Western Blot//Wound Healing Assay//Tube Formation Assay//Co-IP//Migration Assay//qRT-PCR//FISH//RNA-seq//Luciferase Report Assay//ELISA//IHC//ChIP In this study, through deep RNA sequencing on human endometrial cancer (EC) samples and their paired adjacent normal tissues, we uncovered that the circRNA hsa-circ-0000437 is significantly reduced in EC compared with matched paracancerous tissue.  No 34534547 hsa_circ_000516 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3761 No 31026505 hsa_circ_004497 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3760 No 31026505 hsa_circ_004477 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3759 No 31026505 hsa_circ_006908 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3758 No 31026505 hsa_circ_001631 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3757 No 31026505 hsa_circ_002390 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3756 No 31026505 hsa_circ_005800 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3755 No 31026505 hsa_circ_006240 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3754 No 31026505 hsa_circ_005066 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3753 No 31026505 hsa_circ_001412 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3765 No 31026505 hsa_circ_005411 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3766 No 31026505 circPOLA2 CircRNA Homo sapiens Leukemia bone marrow mononuclear cells Interaction(miR-34a) Western Blot//Transfection//CCK8//qRT-PCR//BrdU//Cell Cycle Assay Circ_POLA2 was upregulated in AML and inversely correlated with mature miR-34a, but not miR-34a precursor. In AML cells, overexpression of circ_POLA2 decreased the expression levels of mature miR-34a, but not miR-34a precursor. No 33981162 hsa_circ_000873 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7106 No 31026505 hsa_circ_003549 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7100 No 31026505 hsa_circ_006684 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7101 No 31026505 hsa_circ_000901 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7102 No 31026505 hsa_circ_005715 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7103 No 31026505 hsa_circ_001152 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7104 No 31026505 hsa_circ_003072 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7105 No 31026505 hsa_circ_004701 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7107 No 31026505 hsa_circ_002270 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7114 No 31026505 hsa_circ_003342 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7108 No 31026505 hsa_circ_003055 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7109 No 31026505 hsa_circ_006471 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7110 No 31026505 hsa_circ_002904 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7111 No 31026505 hsa_circ_001733 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7112 No 31026505 hsa_circ_000497 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7113 No 31026505 hsa_circ_006047 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3752 No 31026505 hsa_circ_002729 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3750 No 31026505 hsa_circ_0020397 CircRNA Homo sapiens Luminal Mammary Tumours Luminal Mammary Tumours Regulation Cell Proliferation Assay//Wound Healing Assay//RNA-seq//Western Blot RNA-sequencing experiments performed on the triple-negative/mesenchymal MDA-MB-231 and MDA-MB-157 cell lines engineered to overexpress hsa_circ_0020397 demonstrate that the circRNA influences the expression of 110 common genes. Pathway analysis of these genes indicates that overexpression of the circular RNA differentiates the two mesenchymal cell lines along the epithelial pathway and increases cell-to-cell adhesion. This is accompanied by growth inhibition and a reduction in the random/directional motility of the cell lines. The upregulated AGR2, ENPP1, and PPP1R9A genes as well as the downregulated APOE, AQP3, CD99L2, and IGFBP4 genes show an opposite regulation by hsa_circ_0020397 silencing in luminal CAMA1 cells. No 34771489 hsa_circ_004187 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3749 No 31026505 hsa_circ_000021 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7121 No 31026505 hsa_circ_000824 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3734 No 31026505 hsa_circ_005164 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3733 No 31026505 hsa_circ_004414 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3732 No 31026505 hsa_circ_004156 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3731 No 31026505 hsa_circ_001286 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7122 No 31026505 hsa_circ_000181 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7123 No 31026505 hsa_circ_005457 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7124 No 31026505 hsa_circ_006147 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3730 No 31026505 hsa_circ_001788 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3729 No 31026505 hsa_circ_001382 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7125 No 31026505 hsa_circ_003954 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7126 No 31026505 hsa_circ_000238 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7127 No 31026505 hsa_circ_004653 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7128 No 31026505 hsa_circ_004399 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3728 No 31026505 hsa_circ_003251 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7120 No 31026505 hsa_circ_001251 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7119 No 31026505 hsa_circ_001691 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3735 No 31026505 hsa_circ_001488 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3742 No 31026505 hsa_circ_001677 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3748 No 31026505 hsa_circ_006802 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3747 No 31026505 hsa_circ_005524 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3746 No 31026505 hsa_circ_004196 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3745 No 31026505 hsa_circ_001079 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3744 No 31026505 hsa_circ_003247 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3743 No 31026505 hsa_circ_002561 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3741 No 31026505 hsa_circ_007188 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3736 No 31026505 hsa_circ_001616 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3740 No 31026505 hsa_circ_007039 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7117 No 31026505 hsa_circ_001425 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7118 No 31026505 hsa_circ_003025 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3739 No 31026505 hsa_circ_004467 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3738 No 31026505 hsa_circ_002797 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3737 No 31026505 hsa_circ_005387 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7182 No 31026505 hsa_circ_005990 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3709 No 31026505 hsa_circ_006818 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6943 No 31026505 hsa_circ_003682 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7272 No 31026505 hsa_circ_002407 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3699 No 31026505 hsa_circ_000508 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7257 No 31026505 hsa_circ_003207 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7258 No 31026505 hsa_circ_001237 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7259 No 31026505 hsa_circ_004625 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7260 No 31026505 hsa_circ_002154 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7261 No 31026505 hsa_circ_005928 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7262 No 31026505 hsa_circ_005683 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7263 No 31026505 hsa_circ_004578 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7264 No 31026505 hsa_circ_001039 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7265 No 31026505 hsa_circ_000438 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7266 No 31026505 hsa_circ_005684 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7267 No 31026505 hsa_circ_004402 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7268 No 31026505 hsa_circ_004078 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7269 No 31026505 hsa_circ_003932 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7270 No 31026505 hsa_circ_004499 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7256 No 31026505 hsa_circ_001789 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7255 No 31026505 hsa_circ_000174 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7254 No 31026505 hsa_circ_0005198 CircRNA Homo sapiens Arthritis, Rheumatoid plasma samples from new-onset patients with RA Expression(highly expressed) qRT-PCR//IF//Microarray Circ_0005008 and circ_0005198 were confirmed to be elevated significantly in plasma samples from new-onset patients with RA compared with those from HCs and from patients with systemic lupus erythematosus. Analysis using ROC curves implied that circ_0005008 and circ_0005198 have significant value in the diagnosis of RA. No 34539405 hsa_circ_006210 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7241 No 31026505 hsa_circ_006252 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7242 No 31026505 hsa_circ_005959 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7243 No 31026505 hsa_circ_006477 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7244 No 31026505 hsa_circ_0005008 CircRNA Homo sapiens Arthritis, Rheumatoid plasma samples from new-onset patients with RA Expression(highly expressed) qRT-PCR//IF//Microarray Circ_0005008 and circ_0005198 were confirmed to be elevated significantly in plasma samples from new-onset patients with RA compared with those from HCs and from patients with systemic lupus erythematosus. Analysis using ROC curves implied that circ_0005008 and circ_0005198 have significant value in the diagnosis of RA. No 34539405 hsa_circ_000297 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7245 No 31026505 hsa_circ_006827 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7246 No 31026505 hsa_circ_000191 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7253 No 31026505 hsa_circ_005906 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7247 No 31026505 hsa_circ_005857 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7248 No 31026505 hsa_circ_000073 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7249 No 31026505 hsa_circ_000856 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7250 No 31026505 hsa_circ_003907 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7251 No 31026505 hsa_circ_001187 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7252 No 31026505 hsa_circ_006492 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7271 No 31026505 hsa_circ_006939 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7273 No 31026505 hsa_circ_001234 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3701 No 31026505 hsa_circ_001505 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7274 No 31026505 hsa_circ_006192 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7289 No 31026505 hsa_circ_000405 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3695 No 31026505 hsa_circ_005518 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3694 No 31026505 hsa_circ_002787 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3693 No 31026505 hsa_circ_004215 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7290 No 31026505 hsa_circ_004150 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7291 No 31026505 hsa_circ_000655 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7292 No 31026505 hsa_circ_005117 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3692 No 31026505 hsa_circ_000037 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3691 No 31026505 hsa_circ_001492 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3690 No 31026505 hsa_circ_001265 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3689 No 31026505 hsa_circ_003774 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7293 No 31026505 hsa_circ_0140271 CircRNA Homo sapiens Arthritis, Rheumatoid PBMC Expression(highly expressed) qRT-PCR//ELISA//RNA-seq PBMC expression of hsa_circ_0140271 of female RA was significantly higher than that of female HC, and it was positively correlated with antistreptolysin (ASO). Furthermore, the receiver operating characteristic (ROC) curve indicated that hsa_circ_0140271 could distinguish female RA from female HC and female patients with ankylosing spondylitis (AS) or osteoarthritis (OA). Besides, the combined diagnosis anti-cyclic citrullinated peptide (Anti-CCP) + hsa_circ_0140271 could improve diagnostic accuracy with an area under the curve (AUC) of 0.818 to compared with Anti-CCP. Furthermore, KEGG pathway enrichment analysis indicated hsa_circ_0140271 may act as microRNA sponge and participate in fatty acid metabolism pathways. Furthermore, the receiver operating characteristic (ROC) curve indicated that hsa_circ_0140271 could distinguish female RA from female HC and female patients with ankylosing spondylitis (AS) or osteoarthritis (OA). No 34717684 hsa_circ_005094 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7294 No 31026505 hsa_circ_000024 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7295 No 31026505 hsa_circ_006307 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7288 No 31026505 hsa_circ_000295 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7287 No 31026505 hsa_circ_000929 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3696 No 31026505 hsa_circ_002832 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7279 No 31026505 hsa_circ_006190 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7275 No 31026505 hsa_circ_005502 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7276 No 31026505 hsa_circ_004124 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3698 No 31026505 circUBR4 CircRNA Homo sapiens Atherosclerosis VSMCs Interaction(miR-185-5p/FRS2 axis) RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//EdU Staining//Transwell Assay CircUBR4 was overexpressed in atherosclerosis patients and VSMCs treated with ox-LDL, and the knockdown of circUBR4 abolished ox-LDL-induced enhanced effects on the proliferation and migration of VSMCs. MiR-185-5p, interacted with FRS2, was a target of circUBR4 in VSMCs. The silencing of miR-185-5p reversed the effects caused by circUBR4 knockdown on ox-LDL-induced VSMCs. In addition, overexpression of miR-185-5p suppressed the proliferation and migration of VSMCs by targeting FRS2. CircUBR4 contributed to ox-LDL-induced VSMC proliferation and migration through up-regulating FRS2 via miR-185-5p. No 34159479 hsa_circ_000572 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7277 No 31026505 hsa_circ_000226 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7278 No 31026505 hsa_circ_001701 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7280 No 31026505 hsa_circ_003122 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3697 No 31026505 hsa_circ_000225 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7281 No 31026505 hsa_circ_001588 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7282 No 31026505 hsa_circ_000592 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7283 No 31026505 hsa_circ_006482 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7284 No 31026505 hsa_circ_002978 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7285 No 31026505 hsa_circ_007328 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7286 No 31026505 hsa_circ_002037 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3700 No 31026505 hsa_circ_000039 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3702 No 31026505 hsa_circ_006737 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7184 No 31026505 hsa_circ_003730 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7211 No 31026505 hsa_circ_007051 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7196 No 31026505 hsa_circ_006279 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7197 No 31026505 hsa_circ_003132 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7198 No 31026505 hsa_circ_000293 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7199 No 31026505 hsa_circ_001621 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7200 No 31026505 hsa_circ_006099 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7201 No 31026505 hsa_circ_000553 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7202 No 31026505 hsa_circ_005003 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7203 No 31026505 hsa_circ_004045 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7204 No 31026505 hsa_circ_001535 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7205 No 31026505 hsa_circ_002362 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7206 No 31026505 hsa_circ_000302 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7207 No 31026505 hsa_circ_004710 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7208 No 31026505 hsa_circ_002308 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7209 No 31026505 hsa_circ_006006 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7210 No 31026505 hsa_circ_005774 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7195 No 31026505 hsa_circ_004553 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7194 No 31026505 hsa_circ_0002397 CircRNA Homo sapiens Fabry Disease blood Regulation Phenotyping A distinct circular RNA transcriptome signature identified patients with Fabry disease. Level of circular RNAs hsa_circ_0006853 (AUC=0.73), hsa_circ_0083766 (AUC=0.8) and hsa_circ_0002397 (AUC=0.8) distinguished patients with Fabry disease from both healthy controls and patients with acute kidney injury. No 33547137 hsa_circ_002588 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7188 No 31026505 hsa_circ_006275 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3708 No 31026505 hsa_circ_003586 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7185 No 31026505 hsa_circ_005903 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3707 No 31026505 hsa_circ_004453 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7186 No 31026505 hsa_circ_0001801 CircRNA Homo sapiens Stroke exosomal Regulation qRT-PCR//circRNA-seq//Western Blot Using exosomal circRNA sequencing, large sample validation, and diagnostic model construction revealed that exosomal circ_0043837 and circ_ 0001801were independent predictive factors for LAA stroke, and had better diagnostic efficacy than plasma circRNAs. No 35095932 hsa_circ_003354 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7187 No 31026505 hsa_circ_1002 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC serum and tissue Expression(lower expressed) qRT-PCR//Bioinformatics Analysis circRNA1002 was significantly down-regulated in both HCC serum and tissue, indicating its reliability. No 35782101 hsa_circ_003587 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7193 No 31026505 hsa_circ_006400 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7189 No 31026505 hsa_circ_003952 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7190 No 31026505 hsa_circ_0006853 CircRNA Homo sapiens Fabry Disease blood Regulation Phenotyping A distinct circular RNA transcriptome signature identified patients with Fabry disease. Level of circular RNAs hsa_circ_0006853 (AUC=0.73), hsa_circ_0083766 (AUC=0.8) and hsa_circ_0002397 (AUC=0.8) distinguished patients with Fabry disease from both healthy controls and patients with acute kidney injury. No 33547137 hsa_circ_0083766 CircRNA Homo sapiens Fabry Disease blood Regulation Phenotyping A distinct circular RNA transcriptome signature identified patients with Fabry disease. Level of circular RNAs hsa_circ_0006853 (AUC=0.73), hsa_circ_0083766 (AUC=0.8) and hsa_circ_0002397 (AUC=0.8) distinguished patients with Fabry disease from both healthy controls and patients with acute kidney injury. Hsa_circ_0002397 was, furthermore, female-specifically expressed. No 33547137 hsa_circ_003762 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7191 No 31026505 hsa_circ_003530 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7192 No 31026505 hsa_circ_001502 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3706 No 31026505 hsa_circ_000945 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7212 No 31026505 hsa_circ_001163 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7240 No 31026505 hsa_circ_000240 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7213 No 31026505 hsa_circ_000760 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7229 No 31026505 hsa_circ_004443 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7230 No 31026505 hsa_circ_002325 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7231 No 31026505 hsa_circ_000489 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7232 No 31026505 hsa_circ_006348 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7233 No 31026505 hsa_circ_003029 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7234 No 31026505 hsa_circ_001113 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7235 No 31026505 hsa_circ_005211 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3705 No 31026505 hsa_circ_004077 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7236 No 31026505 hsa_circ_006431 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3704 No 31026505 hsa_circ_003077 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3703 No 31026505 hsa_circ_005830 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7237 No 31026505 hsa_circ_004788 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7238 No 31026505 hsa_circ_000781 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7239 No 31026505 hsa_circ_0078607 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Expression(lower expressed) IF The expression of circ_0078607 was significantly downregulated in ovarian cancer tissues compared with adjacent non-cancerous tissues. Besides, patients with low circ_0078607 expression exhibited parameters associated with poor prognosis, including advanced FIGO stage and higher serum CA125 level. Kaplan-Meier survival curve analysis showed that patients with low circ_0078607 expression had shorter PFS and OS. No 33833570 hsa_circ_005814 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7228 No 31026505 hsa_circ_002556 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7227 No 31026505 hsa_circ_002072 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7226 No 31026505 hsa_circ_000440 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7220 No 31026505 hsa_circ_005885 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7214 No 31026505 hsa_circ_006067 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7215 No 31026505 hsa_circ_001213 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7216 No 31026505 hsa_circ_004635 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7217 No 31026505 hsa_circ_002527 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7218 No 31026505 hsa_circ_003716 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7219 No 31026505 hsa_circ_0028861 CircRNA Homo sapiens Liver Neoplasms serum exosomal Expression(lower expressed) Microarray//qRT-PCR//Western Blot The validation of dysregulated circRNAs by qRT-PCR revealed that serum exosomal hsa_circ_0028861 was decreased in HCC compared to chronic HBV and cirrhosis. Then, hsa_circ_0028861 was identified as a novel biomarker for HCC diagnosis with an area under the ROC curve (AUC) of 0.79 for discriminating HCC from chronic HBV and cirrhosis individuals. Hsa_circ_0028861 was capable of detecting small (AUC = 0.81), early-stage (AUC = 0.82) and AFP-negative [AFP (-)] (AUC = 0.78) tumors as well. No 34367259 hsa_circ_000317 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7225 No 31026505 hsa_circ_003958 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7221 No 31026505 hsa_circ_000182 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7222 No 31026505 lincRNA-Cox2 LncRNA Homo sapiens Acute Lung Injury LPS-induced lung injury Expression(highly expressed) Flow Cytometry//qRT-PCR//ELISA//RNA-seq Using bulk and single-cell RNA sequencing, in addition to FACS, we find that lincRNA-Cox2 is most highly expressed in the lung and is most upregulated after LPS-induced lung injury (acute lung injury [ALI]) within alveolar macrophages, where it functions to regulate inflammation. No 35365562 hsa_circ_000415 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7223 No 31026505 hsa_circ_001965 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7224 No 31026505 circNCLN CircRNA Homo sapiens Acute Lung Injury LPS-induced ALI Interaction(circNCLN/miR-291a-3p/TSLP signaling axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//FISH//Luciferase Report Assay//PCR Mechanistically, our data identified that circNCLN acts as a molecular sponge to antagonize miR-291a-3p and thereby maintaining the expression of TSLP in alveolar epithelial cells. Importantly, targeting circNCLN by its antisense oligonucleotide (ASO) markedly alleviated LPS-induced ALI. Therefore, our results suggested that circNCLN/miR-291a-3p/TSLP axis may be an important signaling in LPS-induced ALI and circNCLN inhibition may serve as a potential treatment of ALI. No 35679712 hsa_circ_001946 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7099 No 31026505 hsa_circ_004571 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7098 No 31026505 hsa_circ_003859 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7097 No 31026505 hsa_circ_000269 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7001 No 31026505 circCASC15 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[highly expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_0026462 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005976 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3825 No 31026505 hsa_circ_001269 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6993 No 31026505 hsa_circ_0065611 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004212 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6994 No 31026505 circDTL CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[highly expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_004143 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6995 No 31026505 hsa_circ_004630 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6996 No 31026505 hsa_circ_004042 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6997 No 31026505 hsa_circ_004231 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6998 No 31026505 hsa_circ_002363 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6999 No 31026505 hsa_circ_004044 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7000 No 31026505 hsa_circ_0081949 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0078299 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_002423 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6992 No 31026505 hsa_circ_003773 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6991 No 31026505 hsa_circ_003815 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6990 No 31026505 hsa_circ_005265 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6983 No 31026505 hsa_circ_0029644 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0037720 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_001149 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6979 No 31026505 hsa_circ_000594 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6980 No 31026505 hsa_circ_003703 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6981 No 31026505 hsa_circ_005154 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6982 No 31026505 hsa_circ_003026 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6984 No 31026505 hsa_circ_000738 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3826 No 31026505 hsa_circ_001723 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6985 No 31026505 hsa_circ_004628 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6986 No 31026505 hsa_circ_006432 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6987 No 31026505 hsa_circ_005068 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6988 No 31026505 hsa_circ_002468 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3827 No 31026505 hsa_circ_004915 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6989 No 31026505 hsa_circ_0024738 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004797 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7002 No 31026505 hsa_circ_006617 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6977 No 31026505 hsa_circ_007232 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7003 No 31026505 hsa_circ_0007333 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_0001524 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_0004592 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_0007482 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 novel_circ_0002126 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_001434 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7014 No 31026505 novel_circ_0006802 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 novel_circ_0008678 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 novel_circ_0009255 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_0007948 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_003415 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7015 No 31026505 novel_circ_0012935 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_005977 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3823 No 31026505 novel_circ_0000151 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 circSKA3 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[highly expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_0023984 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_0023988 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_001710 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3824 No 31026505 hsa_circ_0004846 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 circJMJD1C CircRNA Homo sapiens Breast Neoplasms Breast cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified hsa_circ_0006743 (circJMJD1C) and hsa_circ_0002496 (circAPPBP1) to be significantly up-regulated in early-stage breast cancer tissues. No 33544410 circAPPBP1 CircRNA Homo sapiens Breast Neoplasms Breast cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified hsa_circ_0006743 (circJMJD1C) and hsa_circ_0002496 (circAPPBP1) to be significantly up-regulated in early-stage breast cancer tissues. No 33544410 hsa_circ_004566 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7004 No 31026505 hsa_circ_001333 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7005 No 31026505 hsa_circ_000423 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7006 No 31026505 hsa_circ_006315 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7007 No 31026505 hsa_circ_004343 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7008 No 31026505 hsa_circ_003037 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7013 No 31026505 hsa_circ_005848 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7009 No 31026505 hsa_circ_006195 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7010 No 31026505 hsa_circ_0002454 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_004574 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7011 No 31026505 hsa_circ_0001730 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_007025 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7012 No 31026505 hsa_circ_006167 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6978 No 31026505 hsa_circ_003232 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6976 No 31026505 hsa_circ_004883 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7096 No 31026505 hsa_circ_000498 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6960 No 31026505 hsa_circ_003498 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6955 No 31026505 hsa_circ_004865 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6956 No 31026505 hsa_circ_0020559 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_001278 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3831 No 31026505 hsa_circ_002802 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6957 No 31026505 hsa_circ_000959 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3830 No 31026505 hsa_circ_0045018 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_000784 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6958 No 31026505 hsa_circ_0054281 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0050785 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_003071 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6959 No 31026505 hsa_circ_0051578 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_001524 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3829 No 31026505 hsa_circ_0025413 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0006700 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0049856 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_000852 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6954 No 31026505 hsa_circ_0079543 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_001168 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6948 No 31026505 hsa_circ_000113 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6944 No 31026505 hsa_circ_005444 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6945 No 31026505 hsa_circ_0092196 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005888 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6946 No 31026505 hsa_circ_000281 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6947 No 31026505 hsa_circ_0012817 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004204 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6949 No 31026505 hsa_circ_002477 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6953 No 31026505 hsa_circ_0011420 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004029 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6950 No 31026505 hsa_circ_0005480 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_001174 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6951 No 31026505 hsa_circ_007180 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6952 No 31026505 hsa_circ_006475 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3832 No 31026505 hsa_circ_0066712 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004864 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6961 No 31026505 circUNC13C CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_0046764 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_004759 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6970 No 31026505 hsa_circ_0065603 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0029645 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 circBRWD3 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_003950 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3828 No 31026505 hsa_circ_0009552 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0026463 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_006242 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6971 No 31026505 hsa_circ_0004461 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_000963 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6972 No 31026505 hsa_circ_0075075 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0041062 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_005454 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6973 No 31026505 hsa_circ_003743 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6974 No 31026505 hsa_circ_004480 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6975 No 31026505 hsa_circ_002835 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6969 No 31026505 hsa_circ_006843 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6968 No 31026505 hsa_circ_006844 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6967 No 31026505 hsa_circ_0044345 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0072660 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0023867 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0006569 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0063347 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0079596 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0073309 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0060007 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_0059267 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_002478 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6962 No 31026505 hsa_circ_002801 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6963 No 31026505 hsa_circ_006588 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6964 No 31026505 hsa_circ_0081952 CircRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 hsa_circ_006557 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6965 No 31026505 hsa_circ_003346 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6966 No 31026505 hsa_circ_006505 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7016 No 31026505 hsa_circ_001478 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7017 No 31026505 hsa_circ_002010 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3822 No 31026505 hsa_circ_003564 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7070 No 31026505 hsa_circ_006437 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7061 No 31026505 hsa_circ_006951 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3777 No 31026505 hsa_circ_004621 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3776 No 31026505 hsa_circ_004261 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3775 No 31026505 hsa_circ_002472 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3774 No 31026505 hsa_circ_004532 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3773 No 31026505 hsa_circ_000291 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7062 No 31026505 hsa_circ_002348 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7063 No 31026505 hsa_circ_006931 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7064 No 31026505 hsa_circ_004103 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7065 No 31026505 hsa_circ_0001599 CircRNA Homo sapiens Stroke blood sample of 152 control subjects and 203 IS patients Expression [highly expressed] qRT-PCR//RNA-seq//Bioinformatics Analysis Relative to healthy controls, hsa_circ_0001599 was significantly upregulated in both mild and severe stroke. The hsa_circRNA_0001599 expression levels were positively correlated with the National Institutes of Health Stroke Scale scores and infarct volumes, with an ROC analysis of hsa_circRNA_0001599 in LAA-stroke, yielding an area under the curve of 0.805 (95% confidence interval: 0.748-0.862; p < 0.001), consistent with sensitivity and specificity values of 64.41% and 89.93%, respectively, for the diagnosis of LAA-stroke. The hsa_circRNA_0001599 expression levels were positively correlated with the National Institutes of Health Stroke Scale scores and infarct volumes, with an ROC analysis of hsa_circRNA_0001599 in LAA-stroke, yielding an area under the curve of 0.805 (95% confidence interval: 0.748-0.862; p < 0.001), consistent with sensitivity and specificity values of 64.41% and 89.93%, respectively, for the diagnosis of LAA-stroke. No 33493415 hsa_circ_002232 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7066 No 31026505 hsa_circ_001663 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3772 No 31026505 hsa_circ_007136 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7067 No 31026505 hsa_circ_006112 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7068 No 31026505 novel_circ_0011859 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_002699 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7060 No 31026505 hsa_circ_002534 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7059 No 31026505 hsa_circ_002255 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7051 No 31026505 hsa_circ_003335 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3780 No 31026505 hsa_circ_003975 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3779 No 31026505 hsa_circ_003179 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7048 No 31026505 hsa_circ_002973 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7049 No 31026505 hsa_circ_005462 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7050 No 31026505 hsa_circ_006100 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3778 No 31026505 hsa_circ_006594 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7052 No 31026505 hsa_circ_003718 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7058 No 31026505 hsa_circ_0001675 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_001785 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7053 No 31026505 hsa_circ_003502 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7054 No 31026505 hsa_circ_001634 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7055 No 31026505 hsa_circ_005508 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7056 No 31026505 hsa_circ_001250 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7057 No 31026505 hsa_circ_002822 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7069 No 31026505 hsa_circ_007085 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7071 No 31026505 hsa_circ_005337 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7018 No 31026505 hsa_circ_006298 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7072 No 31026505 hsa_circ_006354 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7088 No 31026505 hsa_circ_003012 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7089 No 31026505 hsa_circ_006945 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3769 No 31026505 hsa_circ_001487 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7090 No 31026505 hsa_circ_003284 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7091 No 31026505 hsa_circ_005301 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3768 No 31026505 hsa_circ_006847 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7092 No 31026505 hsa_circ_000617 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7093 No 31026505 hsa_circ_0003748 CircRNA Homo sapiens rheumatic heart disease hVIC cells Interaction(miR-577/MAPK ) Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//Bioinformatics Analysis//Transwell Assay We found that hsa_circ_0003748 was localized in the cytoplasm; hsa_circ_0003748 promoted the proliferation and migration of hVIC cells, arrested the cell cycle in the G2/M phase, and inhibited apoptosis. These phenomena may result from hsa_circ_0003748 promoting RVHD after sponging miR-577. Bioinformatic analysis revealed that hsa_circ_0003748 might affect RVHD progression by affecting transcription and the MAPK signaling pathway, the Ras signaling pathway, the cAMP signaling pathway, the Rap1 signaling pathway, and other signaling pathways. No 35535387 hsa_circ_0079586 CircRNA Homo sapiens Intracranial Aneurysm the endothelial cells collected from RIAs patients Interaction(miR-183-5p/MPO) Western Blot//Transfection//Genotyping//qRT-PCR//Luciferase Report Assay//Microarray The expression of circRNA-0079586, circRNA-RanGAP1 and MPO was significantly activated in the endothelial cells collected from RIAs patients when compared with UIAs patients, whereas the expression of miR-183-5p and miR-877-3p was remarkably suppressed in the endothelial cells collected from RIAs patients when compared with UIAs patients. No 34611229 hsa_circ_006052 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7094 No 31026505 circRanGAP1 CircRNA Homo sapiens Intracranial Aneurysm the endothelial cells collected from RIAs patients Interaction(miR-877-3p/MPO) Western Blot//Transfection//Genotyping//qRT-PCR//Luciferase Report Assay//Microarray The expression of circRNA-0079586, circRNA-RanGAP1 and MPO was significantly activated in the endothelial cells collected from RIAs patients when compared with UIAs patients, whereas the expression of miR-183-5p and miR-877-3p was remarkably suppressed in the endothelial cells collected from RIAs patients when compared with UIAs patients. No 34611229 hsa_circ_102682 CircRNA Homo sapiens Hyperhomocysteinemia serum samples Expression [lower expressed] qRT-PCR//ELISA Hsa_circRNA_102682 was significantly lower in diabetic patients with high levels of homocysteine than in those with normal levels of homocysteine, whereas transforming growth factor-beta and connective tissue growth factor levels were higher in diabetic patients with hyperhomocysteinemia. Low Hsa_circRNA_102682 was associated with high levels of transforming growth factor-beta and connective tissue growth factor as well as homocysteine and creatinine. No 34296783 hsa_circ_000552 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3767 No 31026505 hsa_circ_006372 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7095 No 31026505 hsa_circ_001564 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3770 No 31026505 hsa_circ_005039 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7087 No 31026505 hsa_circ_002984 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7086 No 31026505 hsa_circ_005553 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7079 No 31026505 hsa_circ_001338 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7073 No 31026505 hsa_circ_006517 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7074 No 31026505 hsa_circ_002860 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7075 No 31026505 hsa_circ_004862 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7076 No 31026505 hsa_circ_006830 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7077 No 31026505 hsa_circ_005261 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7078 No 31026505 hsa_circ_000139 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7080 No 31026505 hsa_circ_005107 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7085 No 31026505 hsa_circ_001453 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7081 No 31026505 hsa_circ_002698 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7082 No 31026505 hsa_circ_000891 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7083 No 31026505 hsa_circ_004207 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7084 No 31026505 hsa_circ_002730 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3771 No 31026505 circVsp27 CircRNA Homo sapiens Virus Diseases BmN cells Regulation Co-IP//qRT-PCR//RNA Pull-Down//Western Blot Altogether, our data suggested that BmCPV derived circRNA-vSP27 with small peptide translation activity may be employed by the host immunity in defense against the BmCPV infection. No 34875309 hsa_circ_007223 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3781 No 31026505 hsa_circ_003281 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3782 No 31026505 hsa_circ_002982 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3783 No 31026505 hsa_circ_004742 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3784 No 31026505 hsa_circ_005336 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7034 No 31026505 hsa_circ_001290 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7035 No 31026505 hsa_circ_000392 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7036 No 31026505 hsa_circ_004125 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3820 No 31026505 hsa_circ_000292 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7037 No 31026505 hsa_circ_001195 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7038 No 31026505 novel_circ_0002011 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_003860 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7039 No 31026505 hsa_circ_003447 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7040 No 31026505 hsa_circ_001504 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7041 No 31026505 hsa_circ_000393 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7042 No 31026505 hsa_circ_006885 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7043 No 31026505 hsa_circ_005647 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7044 No 31026505 hsa_circ_002481 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7045 No 31026505 hsa_circ_005915 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7046 No 31026505 hsa_circ_006149 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3821 No 31026505 hsa_circ_001189 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7033 No 31026505 hsa_circ_004656 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7032 No 31026505 hsa_circ_003761 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7025 No 31026505 hsa_circ_003431 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7019 No 31026505 hsa_circ_002027 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7020 No 31026505 hsa_circ_003904 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7021 No 31026505 hsa_circ_001562 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7022 No 31026505 hsa_circ_002765 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7023 No 31026505 hsa_circ_003340 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7024 No 31026505 hsa_circ_006537 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7026 No 31026505 hsa_circ_0003279 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_006875 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7027 No 31026505 hsa_circ_007093 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7028 No 31026505 hsa_circ_004712 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7029 No 31026505 hsa_circ_0007990 CircRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 hsa_circ_000797 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7030 No 31026505 hsa_circ_001990 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7031 No 31026505 hsa_circ_004205 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.7047 No 31026505 hsa_circ_005911 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3819 No 31026505 hsa_circ_006129 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3818 No 31026505 hsa_circ_006331 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3792 No 31026505 hsa_circ_005303 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3798 No 31026505 hsa_circ_004161 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3797 No 31026505 hsa_circ_006970 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3796 No 31026505 hsa_circ_003998 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3795 No 31026505 hsa_circ_003933 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3794 No 31026505 hsa_circ_001964 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3793 No 31026505 hsa_circ_003558 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3791 No 31026505 hsa_circ_005966 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3800 No 31026505 hsa_circ_003034 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3790 No 31026505 hsa_circ_004407 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3789 No 31026505 hsa_circ_003994 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3788 No 31026505 hsa_circ_002289 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3787 No 31026505 hsa_circ_001960 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3786 No 31026505 hsa_circ_002127 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3785 No 31026505 hsa_circ_005350 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3799 No 31026505 hsa_circ_000130 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3801 No 31026505 hsa_circ_000836 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3817 No 31026505 hsa_circ_006539 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3810 No 31026505 hsa_circ_006913 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3816 No 31026505 hsa_circ_000453 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3815 No 31026505 hsa_circ_003707 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3814 No 31026505 hsa_circ_006947 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3813 No 31026505 hsa_circ_006664 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3812 No 31026505 hsa_circ_005772 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3811 No 31026505 hsa_circ_001296 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3809 No 31026505 hsa_circ_004782 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3802 No 31026505 hsa_circ_006203 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3808 No 31026505 hsa_circ_003552 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3807 No 31026505 hsa_circ_005588 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3806 No 31026505 hsa_circ_003009 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3805 No 31026505 hsa_circ_003519 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3804 No 31026505 hsa_circ_000837 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3803 No 31026505 hsa_circ_000792 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3537 No 31026505 hsa_circ_002007 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6137 No 31026505 hsa_circ_006604 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3535 No 31026505 hsa_circ_002292 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2434 No 31026505 hsa_circ_005482 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2346 No 31026505 hsa_circ_000628 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2347 No 31026505 hsa_circ_004120 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2348 No 31026505 hsa_circ_004530 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2349 No 31026505 hsa_circ_003236 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2350 No 31026505 hsa_circ_005797 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2351 No 31026505 hsa_circ_006573 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2352 No 31026505 hsa_circ_005961 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2353 No 31026505 hsa_circ_001778 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2354 No 31026505 hsa_circ_001413 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2355 No 31026505 hsa_circ_002924 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2356 No 31026505 hsa_circ_005480 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2357 No 31026505 hsa_circ_005390 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2358 No 31026505 hsa_circ_000446 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2359 No 31026505 hsa_circ_003746 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2360 No 31026505 hsa_circ_004236 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2361 No 31026505 hsa_circ_007162 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2362 No 31026505 hsa_circ_004851 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2363 No 31026505 hsa_circ_000083 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2364 No 31026505 hsa_circ_002049 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2365 No 31026505 hsa_circ_005880 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2366 No 31026505 hsa_circ_002148 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2367 No 31026505 hsa_circ_001589 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2368 No 31026505 hsa_circ_002338 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2369 No 31026505 hsa_circ_004685 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2370 No 31026505 hsa_circ_003238 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2371 No 31026505 hsa_circ_003720 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2372 No 31026505 hsa_circ_004284 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2345 No 31026505 hsa_circ_003601 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2344 No 31026505 hsa_circ_002445 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2343 No 31026505 hsa_circ_005292 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2328 No 31026505 hsa_circ_005228 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2316 No 31026505 hsa_circ_000568 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2317 No 31026505 hsa_circ_001950 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2318 No 31026505 hsa_circ_002670 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2319 No 31026505 hsa_circ_004886 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2320 No 31026505 hsa_circ_002435 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2321 No 31026505 hsa_circ_000542 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2322 No 31026505 hsa_circ_001393 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2323 No 31026505 hsa_circ_005182 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2324 No 31026505 hsa_circ_001159 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2325 No 31026505 hsa_circ_003124 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2326 No 31026505 hsa_circ_004327 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2327 No 31026505 hsa_circ_002974 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2329 No 31026505 hsa_circ_006967 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2342 No 31026505 hsa_circ_003981 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2330 No 31026505 hsa_circ_006773 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2331 No 31026505 hsa_circ_001051 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2332 No 31026505 hsa_circ_000581 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2333 No 31026505 hsa_circ_002020 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2334 No 31026505 hsa_circ_003959 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2335 No 31026505 hsa_circ_002294 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2336 No 31026505 hsa_circ_004173 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2337 No 31026505 hsa_circ_003539 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2338 No 31026505 hsa_circ_001298 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2339 No 31026505 hsa_circ_005914 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2340 No 31026505 hsa_circ_000506 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2341 No 31026505 hsa_circ_000071 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2373 No 31026505 hsa_circ_004893 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2374 No 31026505 hsa_circ_003805 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2375 No 31026505 hsa_circ_001161 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2419 No 31026505 hsa_circ_000855 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2407 No 31026505 hsa_circ_004951 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2408 No 31026505 hsa_circ_004953 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2409 No 31026505 hsa_circ_007281 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2410 No 31026505 hsa_circ_005046 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2411 No 31026505 hsa_circ_005363 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2412 No 31026505 hsa_circ_002066 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2413 No 31026505 hsa_circ_005892 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2414 No 31026505 hsa_circ_000558 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2415 No 31026505 hsa_circ_006078 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2416 No 31026505 hsa_circ_002075 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2417 No 31026505 hsa_circ_004696 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2418 No 31026505 hsa_circ_003168 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2420 No 31026505 hsa_circ_005050 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2405 No 31026505 hsa_circ_001211 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2421 No 31026505 hsa_circ_007317 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2422 No 31026505 hsa_circ_002516 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2423 No 31026505 hsa_circ_001199 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2424 No 31026505 hsa_circ_005732 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2425 No 31026505 hsa_circ_005594 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2426 No 31026505 hsa_circ_005282 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2427 No 31026505 hsa_circ_000065 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2428 No 31026505 hsa_circ_005635 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2429 No 31026505 hsa_circ_006822 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2430 No 31026505 hsa_circ_001458 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2431 No 31026505 hsa_circ_001424 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2432 No 31026505 hsa_circ_001185 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2406 No 31026505 hsa_circ_004737 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2404 No 31026505 hsa_circ_001721 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2376 No 31026505 hsa_circ_001437 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2389 No 31026505 hsa_circ_004209 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2377 No 31026505 hsa_circ_006992 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2378 No 31026505 hsa_circ_007263 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2379 No 31026505 hsa_circ_005851 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2380 No 31026505 hsa_circ_003747 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2381 No 31026505 hsa_circ_003205 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2382 No 31026505 hsa_circ_001746 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2383 No 31026505 hsa_circ_000569 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2384 No 31026505 hsa_circ_007249 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2385 No 31026505 hsa_circ_006185 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2386 No 31026505 hsa_circ_003548 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2387 No 31026505 hsa_circ_006878 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2388 No 31026505 hsa_circ_002675 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2390 No 31026505 hsa_circ_001130 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2403 No 31026505 hsa_circ_001429 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2391 No 31026505 hsa_circ_002517 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2392 No 31026505 hsa_circ_002662 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2393 No 31026505 hsa_circ_002023 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2394 No 31026505 hsa_circ_002025 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2395 No 31026505 hsa_circ_000694 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2396 No 31026505 hsa_circ_004011 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2397 No 31026505 hsa_circ_003485 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2398 No 31026505 hsa_circ_002437 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2399 No 31026505 hsa_circ_003908 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2400 No 31026505 hsa_circ_001642 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2401 No 31026505 hsa_circ_006697 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2402 No 31026505 hsa_circ_001587 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2315 No 31026505 hsa_circ_005493 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2314 No 31026505 hsa_circ_006295 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2313 No 31026505 hsa_circ_004808 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2238 No 31026505 hsa_circ_002799 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2226 No 31026505 hsa_circ_004596 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2227 No 31026505 hsa_circ_007287 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2228 No 31026505 hsa_circ_006734 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2229 No 31026505 hsa_circ_003063 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2230 No 31026505 hsa_circ_003844 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2231 No 31026505 hsa_circ_001282 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2232 No 31026505 hsa_circ_003785 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2233 No 31026505 hsa_circ_006525 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2234 No 31026505 hsa_circ_002804 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2235 No 31026505 hsa_circ_005328 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2236 No 31026505 hsa_circ_004857 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2237 No 31026505 hsa_circ_000615 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2239 No 31026505 hsa_circ_003699 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2224 No 31026505 hsa_circ_005093 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2240 No 31026505 hsa_circ_004585 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2241 No 31026505 hsa_circ_005770 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2242 No 31026505 hsa_circ_006940 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2243 No 31026505 hsa_circ_002725 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2244 No 31026505 hsa_circ_006961 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2245 No 31026505 hsa_circ_007182 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2246 No 31026505 hsa_circ_001799 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2247 No 31026505 hsa_circ_004892 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2248 No 31026505 hsa_circ_003922 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2249 No 31026505 hsa_circ_006408 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2250 No 31026505 hsa_circ_004854 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2251 No 31026505 hsa_circ_000675 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2225 No 31026505 hsa_circ_005621 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2223 No 31026505 hsa_circ_001671 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2253 No 31026505 hsa_circ_006306 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2208 No 31026505 hsa_circ_005327 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2196 No 31026505 hsa_circ_002187 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2197 No 31026505 hsa_circ_002498 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2198 No 31026505 hsa_circ_004827 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2199 No 31026505 hsa_circ_001430 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2200 No 31026505 hsa_circ_004309 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2201 No 31026505 hsa_circ_001725 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2202 No 31026505 hsa_circ_005017 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2203 No 31026505 hsa_circ_000769 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2204 No 31026505 hsa_circ_000711 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2205 No 31026505 hsa_circ_005869 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2206 No 31026505 hsa_circ_005002 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2207 No 31026505 hsa_circ_002563 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2209 No 31026505 hsa_circ_004493 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2222 No 31026505 hsa_circ_002216 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2210 No 31026505 hsa_circ_000547 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2211 No 31026505 hsa_circ_003598 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2212 No 31026505 hsa_circ_003181 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2213 No 31026505 hsa_circ_006663 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2214 No 31026505 hsa_circ_005409 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2215 No 31026505 hsa_circ_001819 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2216 No 31026505 hsa_circ_005609 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2217 No 31026505 hsa_circ_000422 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2218 No 31026505 hsa_circ_001722 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2219 No 31026505 hsa_circ_002618 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2220 No 31026505 hsa_circ_007123 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2221 No 31026505 hsa_circ_002840 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2252 No 31026505 hsa_circ_001713 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2254 No 31026505 hsa_circ_001795 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2312 No 31026505 hsa_circ_005829 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2298 No 31026505 hsa_circ_002994 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2286 No 31026505 hsa_circ_005953 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2287 No 31026505 hsa_circ_003363 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2288 No 31026505 hsa_circ_005733 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2289 No 31026505 hsa_circ_006186 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2290 No 31026505 hsa_circ_005841 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2291 No 31026505 hsa_circ_005828 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2292 No 31026505 hsa_circ_006873 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2293 No 31026505 hsa_circ_006660 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2294 No 31026505 hsa_circ_001322 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2295 No 31026505 hsa_circ_004317 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2296 No 31026505 hsa_circ_004246 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2297 No 31026505 hsa_circ_005381 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2299 No 31026505 hsa_circ_004811 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2284 No 31026505 hsa_circ_005701 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2300 No 31026505 hsa_circ_000707 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2301 No 31026505 hsa_circ_006787 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2302 No 31026505 hsa_circ_006866 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2303 No 31026505 hsa_circ_007134 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2304 No 31026505 hsa_circ_006234 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2305 No 31026505 hsa_circ_007302 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2306 No 31026505 hsa_circ_006828 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2307 No 31026505 hsa_circ_002918 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2308 No 31026505 hsa_circ_002377 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2309 No 31026505 hsa_circ_004974 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2310 No 31026505 hsa_circ_002479 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2311 No 31026505 hsa_circ_002942 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2285 No 31026505 hsa_circ_002528 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2283 No 31026505 hsa_circ_000216 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2255 No 31026505 hsa_circ_002358 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2268 No 31026505 hsa_circ_003508 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2256 No 31026505 hsa_circ_000374 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2257 No 31026505 hsa_circ_007171 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2258 No 31026505 hsa_circ_004186 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2259 No 31026505 hsa_circ_000126 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2260 No 31026505 hsa_circ_006454 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2261 No 31026505 hsa_circ_006983 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2262 No 31026505 hsa_circ_006984 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2263 No 31026505 hsa_circ_001206 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2264 No 31026505 hsa_circ_001117 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2265 No 31026505 hsa_circ_001977 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2266 No 31026505 hsa_circ_006412 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2267 No 31026505 hsa_circ_007228 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2269 No 31026505 hsa_circ_003149 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2282 No 31026505 hsa_circ_001815 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2270 No 31026505 hsa_circ_005539 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2271 No 31026505 hsa_circ_001681 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2272 No 31026505 hsa_circ_006406 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2273 No 31026505 hsa_circ_001169 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2274 No 31026505 hsa_circ_004342 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2275 No 31026505 hsa_circ_005475 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2276 No 31026505 hsa_circ_003613 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2277 No 31026505 hsa_circ_002585 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2278 No 31026505 hsa_circ_000137 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2279 No 31026505 hsa_circ_003679 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2280 No 31026505 hsa_circ_004473 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2281 No 31026505 hsa_circ_006325 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2433 No 31026505 hsa_circ_006917 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2435 No 31026505 hsa_circ_003182 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2675 No 31026505 hsa_circ_002242 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2436 No 31026505 hsa_circ_007233 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2587 No 31026505 hsa_circ_005433 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2588 No 31026505 hsa_circ_006856 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2589 No 31026505 hsa_circ_001442 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2590 No 31026505 hsa_circ_003262 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2591 No 31026505 hsa_circ_006890 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2592 No 31026505 hsa_circ_000234 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2593 No 31026505 hsa_circ_003591 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2594 No 31026505 hsa_circ_005854 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2595 No 31026505 hsa_circ_000383 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2596 No 31026505 hsa_circ_001307 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2597 No 31026505 hsa_circ_001339 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2598 No 31026505 hsa_circ_001506 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2599 No 31026505 hsa_circ_002659 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2600 No 31026505 hsa_circ_003532 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2601 No 31026505 hsa_circ_004768 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2602 No 31026505 hsa_circ_004779 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2603 No 31026505 hsa_circ_002293 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2604 No 31026505 hsa_circ_007124 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2605 No 31026505 hsa_circ_000097 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2606 No 31026505 hsa_circ_005268 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2607 No 31026505 hsa_circ_000013 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2608 No 31026505 hsa_circ_005950 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2609 No 31026505 hsa_circ_006930 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2610 No 31026505 hsa_circ_000128 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2611 No 31026505 hsa_circ_006445 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2612 No 31026505 hsa_circ_004279 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2613 No 31026505 hsa_circ_003789 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2586 No 31026505 hsa_circ_004795 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2585 No 31026505 hsa_circ_000619 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2584 No 31026505 hsa_circ_007033 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2569 No 31026505 hsa_circ_001485 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2557 No 31026505 hsa_circ_002421 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2558 No 31026505 hsa_circ_003928 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2559 No 31026505 hsa_circ_006804 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2560 No 31026505 hsa_circ_003499 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2561 No 31026505 hsa_circ_006633 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2562 No 31026505 hsa_circ_005052 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2563 No 31026505 hsa_circ_007256 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2564 No 31026505 hsa_circ_004576 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2565 No 31026505 hsa_circ_001617 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2566 No 31026505 hsa_circ_004474 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2567 No 31026505 hsa_circ_001495 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2568 No 31026505 hsa_circ_004816 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2570 No 31026505 hsa_circ_000691 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2583 No 31026505 hsa_circ_006243 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2571 No 31026505 hsa_circ_003875 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2572 No 31026505 hsa_circ_005283 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2573 No 31026505 hsa_circ_005895 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2574 No 31026505 hsa_circ_006196 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2575 No 31026505 hsa_circ_004159 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2576 No 31026505 hsa_circ_000221 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2577 No 31026505 hsa_circ_006040 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2578 No 31026505 hsa_circ_006341 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2579 No 31026505 hsa_circ_004421 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2580 No 31026505 hsa_circ_003362 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2581 No 31026505 hsa_circ_003087 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2582 No 31026505 hsa_circ_000989 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2614 No 31026505 hsa_circ_004117 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2615 No 31026505 hsa_circ_005004 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2616 No 31026505 hsa_circ_006161 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2660 No 31026505 hsa_circ_003635 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2648 No 31026505 hsa_circ_004494 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2649 No 31026505 hsa_circ_001325 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2650 No 31026505 hsa_circ_006356 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2651 No 31026505 hsa_circ_006694 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2652 No 31026505 hsa_circ_002625 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2653 No 31026505 hsa_circ_003170 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2654 No 31026505 hsa_circ_005257 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2655 No 31026505 hsa_circ_001807 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2656 No 31026505 hsa_circ_001124 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2657 No 31026505 hsa_circ_006355 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2658 No 31026505 hsa_circ_000954 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2659 No 31026505 hsa_circ_006130 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2661 No 31026505 hsa_circ_004555 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2646 No 31026505 hsa_circ_007116 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2662 No 31026505 hsa_circ_002012 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2663 No 31026505 hsa_circ_002735 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2664 No 31026505 hsa_circ_005019 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2665 No 31026505 hsa_circ_004234 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2666 No 31026505 hsa_circ_007148 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2667 No 31026505 hsa_circ_005016 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2668 No 31026505 hsa_circ_005076 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2669 No 31026505 hsa_circ_003578 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2670 No 31026505 hsa_circ_000709 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2671 No 31026505 hsa_circ_002909 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2672 No 31026505 hsa_circ_003979 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2673 No 31026505 hsa_circ_000194 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2647 No 31026505 hsa_circ_003414 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2645 No 31026505 hsa_circ_002224 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2617 No 31026505 hsa_circ_003469 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2630 No 31026505 hsa_circ_002646 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2618 No 31026505 hsa_circ_001132 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2619 No 31026505 hsa_circ_001482 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2620 No 31026505 hsa_circ_006401 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2621 No 31026505 hsa_circ_000534 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2622 No 31026505 hsa_circ_000252 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2623 No 31026505 hsa_circ_007318 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2624 No 31026505 hsa_circ_002716 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2625 No 31026505 hsa_circ_006680 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2626 No 31026505 hsa_circ_004404 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2627 No 31026505 hsa_circ_005329 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2628 No 31026505 hsa_circ_005025 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2629 No 31026505 hsa_circ_006248 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2631 No 31026505 hsa_circ_002959 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2644 No 31026505 hsa_circ_007268 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2632 No 31026505 hsa_circ_000430 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2633 No 31026505 hsa_circ_002536 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2634 No 31026505 hsa_circ_001989 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2635 No 31026505 hsa_circ_007267 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2636 No 31026505 hsa_circ_003840 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2637 No 31026505 hsa_circ_007244 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2638 No 31026505 hsa_circ_002274 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2639 No 31026505 hsa_circ_002158 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2640 No 31026505 hsa_circ_001236 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2641 No 31026505 hsa_circ_001571 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2642 No 31026505 hsa_circ_004639 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2643 No 31026505 hsa_circ_002947 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2556 No 31026505 hsa_circ_004417 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2555 No 31026505 hsa_circ_004293 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2554 No 31026505 hsa_circ_007027 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2479 No 31026505 hsa_circ_003371 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2467 No 31026505 hsa_circ_003097 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2468 No 31026505 hsa_circ_007016 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2469 No 31026505 hsa_circ_001226 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2470 No 31026505 hsa_circ_003044 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2471 No 31026505 hsa_circ_002927 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2472 No 31026505 hsa_circ_002652 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2473 No 31026505 hsa_circ_003713 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2474 No 31026505 hsa_circ_006125 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2475 No 31026505 hsa_circ_006681 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2476 No 31026505 hsa_circ_002601 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2477 No 31026505 hsa_circ_000877 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2478 No 31026505 hsa_circ_000566 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2480 No 31026505 hsa_circ_004360 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2465 No 31026505 hsa_circ_003847 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2481 No 31026505 hsa_circ_005007 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2482 No 31026505 hsa_circ_006340 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2483 No 31026505 hsa_circ_002767 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2484 No 31026505 hsa_circ_006396 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2485 No 31026505 hsa_circ_006893 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2486 No 31026505 hsa_circ_002861 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2487 No 31026505 hsa_circ_005794 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2488 No 31026505 hsa_circ_005432 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2489 No 31026505 hsa_circ_002237 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2490 No 31026505 hsa_circ_003047 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2491 No 31026505 hsa_circ_003010 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2492 No 31026505 hsa_circ_000529 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2466 No 31026505 hsa_circ_003819 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2464 No 31026505 hsa_circ_002538 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2494 No 31026505 hsa_circ_005187 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2449 No 31026505 hsa_circ_001510 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2437 No 31026505 hsa_circ_000562 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2438 No 31026505 hsa_circ_000151 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2439 No 31026505 hsa_circ_007071 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2440 No 31026505 hsa_circ_000625 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2441 No 31026505 hsa_circ_001813 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2442 No 31026505 hsa_circ_003254 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2443 No 31026505 hsa_circ_002508 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2444 No 31026505 hsa_circ_007028 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2445 No 31026505 hsa_circ_000100 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2446 No 31026505 hsa_circ_007072 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2447 No 31026505 hsa_circ_002389 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2448 No 31026505 hsa_circ_004010 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2450 No 31026505 hsa_circ_001694 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2463 No 31026505 hsa_circ_005005 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2451 No 31026505 hsa_circ_001027 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2452 No 31026505 hsa_circ_003305 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2453 No 31026505 hsa_circ_004715 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2454 No 31026505 hsa_circ_003450 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2455 No 31026505 hsa_circ_005027 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2456 No 31026505 hsa_circ_003272 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2457 No 31026505 hsa_circ_004802 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2458 No 31026505 hsa_circ_000307 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2459 No 31026505 hsa_circ_004119 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2460 No 31026505 hsa_circ_000064 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2461 No 31026505 hsa_circ_006750 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2462 No 31026505 hsa_circ_006135 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2493 No 31026505 hsa_circ_004437 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2495 No 31026505 hsa_circ_004868 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2553 No 31026505 hsa_circ_003002 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2539 No 31026505 hsa_circ_002970 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2527 No 31026505 hsa_circ_003782 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2528 No 31026505 hsa_circ_004690 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2529 No 31026505 hsa_circ_006384 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2530 No 31026505 hsa_circ_004800 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2531 No 31026505 hsa_circ_000727 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2532 No 31026505 hsa_circ_004232 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2533 No 31026505 hsa_circ_004632 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2534 No 31026505 hsa_circ_001422 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2535 No 31026505 hsa_circ_001126 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2536 No 31026505 hsa_circ_003350 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2537 No 31026505 hsa_circ_004481 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2538 No 31026505 hsa_circ_000764 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2540 No 31026505 hsa_circ_005927 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2525 No 31026505 hsa_circ_000548 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2541 No 31026505 hsa_circ_000109 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2542 No 31026505 hsa_circ_000250 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2543 No 31026505 hsa_circ_001633 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2544 No 31026505 hsa_circ_003258 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2545 No 31026505 hsa_circ_002916 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2546 No 31026505 hsa_circ_007250 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2547 No 31026505 hsa_circ_004569 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2548 No 31026505 hsa_circ_005481 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2549 No 31026505 hsa_circ_003330 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2550 No 31026505 hsa_circ_005288 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2551 No 31026505 hsa_circ_002943 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2552 No 31026505 hsa_circ_004262 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2526 No 31026505 hsa_circ_000125 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2524 No 31026505 hsa_circ_005779 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2496 No 31026505 hsa_circ_003078 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2509 No 31026505 hsa_circ_000159 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2497 No 31026505 hsa_circ_005898 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2498 No 31026505 hsa_circ_005263 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2499 No 31026505 hsa_circ_006201 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2500 No 31026505 hsa_circ_007135 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2501 No 31026505 hsa_circ_006103 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2502 No 31026505 hsa_circ_004708 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2503 No 31026505 hsa_circ_005379 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2504 No 31026505 hsa_circ_005293 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2505 No 31026505 hsa_circ_001767 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2506 No 31026505 hsa_circ_001554 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2507 No 31026505 hsa_circ_000479 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2508 No 31026505 hsa_circ_002241 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2510 No 31026505 hsa_circ_005214 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2523 No 31026505 hsa_circ_005758 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2511 No 31026505 hsa_circ_001439 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2512 No 31026505 hsa_circ_000304 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2513 No 31026505 hsa_circ_002335 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2514 No 31026505 hsa_circ_003484 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2515 No 31026505 hsa_circ_005634 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2516 No 31026505 hsa_circ_003287 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2517 No 31026505 hsa_circ_004216 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2518 No 31026505 hsa_circ_001420 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2519 No 31026505 hsa_circ_004243 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2520 No 31026505 hsa_circ_004846 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2521 No 31026505 hsa_circ_007314 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2522 No 31026505 hsa_circ_002247 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2195 No 31026505 hsa_circ_001170 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2194 No 31026505 hsa_circ_004828 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2193 No 31026505 hsa_circ_007048 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2192 No 31026505 hsa_circ_003672 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1865 No 31026505 hsa_circ_006677 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1866 No 31026505 hsa_circ_000187 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1867 No 31026505 hsa_circ_004274 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1868 No 31026505 hsa_circ_001560 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1869 No 31026505 hsa_circ_001543 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1870 No 31026505 hsa_circ_005391 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1871 No 31026505 hsa_circ_005109 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1872 No 31026505 hsa_circ_004683 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1873 No 31026505 hsa_circ_004589 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1874 No 31026505 hsa_circ_000232 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1875 No 31026505 hsa_circ_004330 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1876 No 31026505 hsa_circ_005312 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1877 No 31026505 hsa_circ_003594 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1878 No 31026505 hsa_circ_000155 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1879 No 31026505 hsa_circ_006239 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1880 No 31026505 hsa_circ_006607 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1881 No 31026505 hsa_circ_000230 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1882 No 31026505 hsa_circ_006958 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1883 No 31026505 hsa_circ_005434 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1884 No 31026505 hsa_circ_004033 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1885 No 31026505 hsa_circ_002406 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1886 No 31026505 hsa_circ_006018 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1887 No 31026505 hsa_circ_004962 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1888 No 31026505 hsa_circ_000421 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1889 No 31026505 hsa_circ_003685 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1890 No 31026505 hsa_circ_000507 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1891 No 31026505 hsa_circ_001436 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1864 No 31026505 hsa_circ_003442 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1863 No 31026505 hsa_circ_002677 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1862 No 31026505 hsa_circ_007216 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1847 No 31026505 hsa_circ_003768 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1835 No 31026505 hsa_circ_003696 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1836 No 31026505 hsa_circ_001638 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1837 No 31026505 hsa_circ_005041 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1838 No 31026505 hsa_circ_000779 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1839 No 31026505 hsa_circ_005641 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1840 No 31026505 hsa_circ_001899 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1841 No 31026505 hsa_circ_003493 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1842 No 31026505 hsa_circ_006362 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1843 No 31026505 hsa_circ_000857 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1844 No 31026505 hsa_circ_001607 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1845 No 31026505 hsa_circ_006645 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1846 No 31026505 hsa_circ_004853 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1848 No 31026505 hsa_circ_001980 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1861 No 31026505 hsa_circ_004684 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1849 No 31026505 hsa_circ_001891 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1850 No 31026505 hsa_circ_003767 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1851 No 31026505 hsa_circ_003058 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1852 No 31026505 hsa_circ_003623 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1853 No 31026505 hsa_circ_001814 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1854 No 31026505 hsa_circ_006596 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1855 No 31026505 hsa_circ_001699 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1856 No 31026505 hsa_circ_000801 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1857 No 31026505 hsa_circ_000757 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1858 No 31026505 hsa_circ_006920 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1859 No 31026505 hsa_circ_000253 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1860 No 31026505 hsa_circ_001595 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1892 No 31026505 hsa_circ_001486 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1893 No 31026505 hsa_circ_000166 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1894 No 31026505 hsa_circ_004850 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1938 No 31026505 hsa_circ_003391 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1926 No 31026505 hsa_circ_004113 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1927 No 31026505 hsa_circ_005479 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1928 No 31026505 hsa_circ_000651 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1929 No 31026505 hsa_circ_002743 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1930 No 31026505 hsa_circ_000733 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1931 No 31026505 hsa_circ_000249 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1932 No 31026505 hsa_circ_003858 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1933 No 31026505 hsa_circ_006679 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1934 No 31026505 hsa_circ_006346 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1935 No 31026505 hsa_circ_004163 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1936 No 31026505 hsa_circ_003393 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1937 No 31026505 hsa_circ_001244 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1939 No 31026505 hsa_circ_005500 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1924 No 31026505 hsa_circ_000441 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1940 No 31026505 hsa_circ_003196 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1941 No 31026505 hsa_circ_001892 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1942 No 31026505 hsa_circ_003036 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1943 No 31026505 hsa_circ_002062 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1944 No 31026505 hsa_circ_004359 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1945 No 31026505 hsa_circ_000613 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1946 No 31026505 hsa_circ_002369 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1947 No 31026505 hsa_circ_004154 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1948 No 31026505 hsa_circ_007152 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1949 No 31026505 hsa_circ_005166 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1950 No 31026505 hsa_circ_001391 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1951 No 31026505 hsa_circ_003574 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1925 No 31026505 hsa_circ_006377 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1923 No 31026505 hsa_circ_006968 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1895 No 31026505 hsa_circ_006415 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1908 No 31026505 hsa_circ_001731 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1896 No 31026505 hsa_circ_000861 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1897 No 31026505 hsa_circ_003222 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1898 No 31026505 hsa_circ_001542 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1899 No 31026505 hsa_circ_005113 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1900 No 31026505 hsa_circ_002586 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1901 No 31026505 hsa_circ_005144 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1902 No 31026505 hsa_circ_006707 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1903 No 31026505 hsa_circ_007149 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1904 No 31026505 hsa_circ_002316 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1905 No 31026505 hsa_circ_006810 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1906 No 31026505 hsa_circ_000763 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1907 No 31026505 hsa_circ_002144 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1909 No 31026505 hsa_circ_003276 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1922 No 31026505 hsa_circ_001762 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1910 No 31026505 hsa_circ_001889 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1911 No 31026505 hsa_circ_000869 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1912 No 31026505 hsa_circ_006350 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1913 No 31026505 hsa_circ_002546 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1914 No 31026505 hsa_circ_004354 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1915 No 31026505 hsa_circ_007217 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1916 No 31026505 hsa_circ_001052 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1917 No 31026505 hsa_circ_000808 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1918 No 31026505 hsa_circ_003971 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1919 No 31026505 hsa_circ_007254 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1920 No 31026505 hsa_circ_001930 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1921 No 31026505 hsa_circ_005781 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1834 No 31026505 hsa_circ_006469 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1833 No 31026505 hsa_circ_002875 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1832 No 31026505 hsa_circ_002991 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1757 No 31026505 hsa_circ_002505 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1745 No 31026505 hsa_circ_003880 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1746 No 31026505 hsa_circ_006193 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1747 No 31026505 hsa_circ_003020 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1748 No 31026505 hsa_circ_004921 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1749 No 31026505 hsa_circ_007133 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1750 No 31026505 hsa_circ_001012 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1751 No 31026505 hsa_circ_005056 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1752 No 31026505 hsa_circ_004275 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1753 No 31026505 hsa_circ_002436 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1754 No 31026505 hsa_circ_000884 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1755 No 31026505 hsa_circ_006468 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1756 No 31026505 hsa_circ_001268 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1758 No 31026505 hsa_circ_005753 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1743 No 31026505 hsa_circ_003544 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1759 No 31026505 hsa_circ_000285 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1760 No 31026505 hsa_circ_002751 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1761 No 31026505 hsa_circ_001640 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1762 No 31026505 hsa_circ_000853 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1763 No 31026505 hsa_circ_006132 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1764 No 31026505 hsa_circ_001718 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1765 No 31026505 hsa_circ_003174 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1766 No 31026505 hsa_circ_005945 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1767 No 31026505 hsa_circ_001781 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1768 No 31026505 hsa_circ_001639 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1769 No 31026505 hsa_circ_004547 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1770 No 31026505 hsa_circ_004540 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1744 No 31026505 hsa_circ_004738 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1742 No 31026505 hsa_circ_004319 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1772 No 31026505 hsa_circ_000179 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1727 No 31026505 hsa_circ_001945 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1715 No 31026505 hsa_circ_004704 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1716 No 31026505 hsa_circ_002638 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1717 No 31026505 hsa_circ_002222 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1718 No 31026505 hsa_circ_006960 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1719 No 31026505 hsa_circ_005084 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1720 No 31026505 hsa_circ_001380 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1721 No 31026505 hsa_circ_001976 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1722 No 31026505 hsa_circ_004115 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1723 No 31026505 hsa_circ_004600 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1724 No 31026505 hsa_circ_000419 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1725 No 31026505 hsa_circ_006388 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1726 No 31026505 hsa_circ_002857 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1728 No 31026505 hsa_circ_002163 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1741 No 31026505 hsa_circ_005382 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1729 No 31026505 hsa_circ_003395 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1730 No 31026505 hsa_circ_000809 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1731 No 31026505 hsa_circ_001031 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1732 No 31026505 hsa_circ_000180 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1733 No 31026505 hsa_circ_001068 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1734 No 31026505 hsa_circ_006425 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1735 No 31026505 hsa_circ_003597 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1736 No 31026505 hsa_circ_006211 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1737 No 31026505 hsa_circ_001416 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1738 No 31026505 hsa_circ_002215 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1739 No 31026505 hsa_circ_004686 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1740 No 31026505 hsa_circ_001017 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1771 No 31026505 hsa_circ_005386 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1773 No 31026505 hsa_circ_004823 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1831 No 31026505 hsa_circ_002853 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1817 No 31026505 hsa_circ_004773 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1805 No 31026505 hsa_circ_004954 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1806 No 31026505 hsa_circ_003808 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1807 No 31026505 hsa_circ_004866 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1808 No 31026505 hsa_circ_002339 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1809 No 31026505 hsa_circ_003863 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1810 No 31026505 hsa_circ_006998 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1811 No 31026505 hsa_circ_005351 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1812 No 31026505 hsa_circ_004093 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1813 No 31026505 hsa_circ_006711 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1814 No 31026505 hsa_circ_003208 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1815 No 31026505 hsa_circ_001597 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1816 No 31026505 hsa_circ_006391 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1818 No 31026505 hsa_circ_000504 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1803 No 31026505 hsa_circ_006304 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1819 No 31026505 hsa_circ_001893 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1820 No 31026505 hsa_circ_002595 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1821 No 31026505 hsa_circ_004604 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1822 No 31026505 hsa_circ_003157 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1823 No 31026505 hsa_circ_005873 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1824 No 31026505 hsa_circ_000353 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1825 No 31026505 hsa_circ_004539 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1826 No 31026505 hsa_circ_004276 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1827 No 31026505 hsa_circ_003158 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1828 No 31026505 hsa_circ_004936 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1829 No 31026505 hsa_circ_004257 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1830 No 31026505 hsa_circ_004379 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1804 No 31026505 hsa_circ_000195 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1802 No 31026505 hsa_circ_004377 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1774 No 31026505 hsa_circ_003694 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1787 No 31026505 hsa_circ_004385 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1775 No 31026505 hsa_circ_007218 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1776 No 31026505 hsa_circ_006675 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1777 No 31026505 hsa_circ_006182 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1778 No 31026505 hsa_circ_003123 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1779 No 31026505 hsa_circ_004643 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1780 No 31026505 hsa_circ_006823 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1781 No 31026505 hsa_circ_003116 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1782 No 31026505 hsa_circ_002317 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1783 No 31026505 hsa_circ_004324 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1784 No 31026505 hsa_circ_004912 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1785 No 31026505 hsa_circ_000633 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1786 No 31026505 hsa_circ_001276 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1788 No 31026505 hsa_circ_003674 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1801 No 31026505 hsa_circ_001319 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1789 No 31026505 hsa_circ_005412 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1790 No 31026505 hsa_circ_002955 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1791 No 31026505 hsa_circ_004860 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1792 No 31026505 hsa_circ_006881 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1793 No 31026505 hsa_circ_003298 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1794 No 31026505 hsa_circ_003088 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1795 No 31026505 hsa_circ_000480 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1796 No 31026505 hsa_circ_003709 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1797 No 31026505 hsa_circ_004114 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1798 No 31026505 hsa_circ_002518 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1799 No 31026505 hsa_circ_004004 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1800 No 31026505 hsa_circ_004810 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1952 No 31026505 hsa_circ_005034 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1953 No 31026505 hsa_circ_005242 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1954 No 31026505 hsa_circ_004190 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2118 No 31026505 hsa_circ_004370 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2106 No 31026505 hsa_circ_006148 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2107 No 31026505 hsa_circ_002248 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2108 No 31026505 hsa_circ_000476 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2109 No 31026505 hsa_circ_004762 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2110 No 31026505 hsa_circ_005333 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2111 No 31026505 hsa_circ_003004 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2112 No 31026505 hsa_circ_004069 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2113 No 31026505 hsa_circ_005010 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2114 No 31026505 hsa_circ_000885 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2115 No 31026505 hsa_circ_004680 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2116 No 31026505 hsa_circ_005834 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2117 No 31026505 hsa_circ_006324 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2119 No 31026505 hsa_circ_004858 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2104 No 31026505 hsa_circ_003624 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2120 No 31026505 hsa_circ_003714 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2121 No 31026505 hsa_circ_000096 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2122 No 31026505 hsa_circ_004206 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2123 No 31026505 hsa_circ_006669 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2124 No 31026505 hsa_circ_001572 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2125 No 31026505 hsa_circ_004666 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2126 No 31026505 hsa_circ_006328 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2127 No 31026505 hsa_circ_005754 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2128 No 31026505 hsa_circ_005232 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2129 No 31026505 hsa_circ_000445 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2130 No 31026505 hsa_circ_003879 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2131 No 31026505 hsa_circ_004754 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2105 No 31026505 hsa_circ_000391 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2103 No 31026505 hsa_circ_004210 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2133 No 31026505 hsa_circ_001221 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2088 No 31026505 hsa_circ_003163 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2076 No 31026505 hsa_circ_000404 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2077 No 31026505 hsa_circ_006231 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2078 No 31026505 hsa_circ_002896 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2079 No 31026505 hsa_circ_004158 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2080 No 31026505 hsa_circ_003501 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2081 No 31026505 hsa_circ_004224 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2082 No 31026505 hsa_circ_004920 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2083 No 31026505 hsa_circ_004837 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2084 No 31026505 hsa_circ_000669 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2085 No 31026505 hsa_circ_003990 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2086 No 31026505 hsa_circ_002632 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2087 No 31026505 hsa_circ_002945 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2089 No 31026505 hsa_circ_004935 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2102 No 31026505 hsa_circ_004298 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2090 No 31026505 hsa_circ_003936 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2091 No 31026505 hsa_circ_005148 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2092 No 31026505 hsa_circ_001118 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2093 No 31026505 hsa_circ_002149 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2094 No 31026505 hsa_circ_005784 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2095 No 31026505 hsa_circ_002128 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2096 No 31026505 hsa_circ_005653 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2097 No 31026505 hsa_circ_002726 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2098 No 31026505 hsa_circ_007300 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2099 No 31026505 hsa_circ_000222 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2100 No 31026505 hsa_circ_002473 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2101 No 31026505 hsa_circ_005923 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2132 No 31026505 hsa_circ_001443 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2134 No 31026505 hsa_circ_004335 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2074 No 31026505 hsa_circ_005993 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2178 No 31026505 hsa_circ_005542 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2166 No 31026505 hsa_circ_001894 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2167 No 31026505 hsa_circ_002844 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2168 No 31026505 hsa_circ_005968 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2169 No 31026505 hsa_circ_001644 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2170 No 31026505 hsa_circ_001682 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2171 No 31026505 hsa_circ_003237 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2172 No 31026505 hsa_circ_000607 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2173 No 31026505 hsa_circ_001312 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2174 No 31026505 hsa_circ_002440 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2175 No 31026505 hsa_circ_005030 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2176 No 31026505 hsa_circ_002044 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2177 No 31026505 hsa_circ_001392 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2179 No 31026505 hsa_circ_006543 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2164 No 31026505 hsa_circ_003897 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2180 No 31026505 hsa_circ_005065 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2181 No 31026505 hsa_circ_006270 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2182 No 31026505 hsa_circ_002695 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2183 No 31026505 hsa_circ_005823 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2184 No 31026505 hsa_circ_006217 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2185 No 31026505 hsa_circ_006032 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2186 No 31026505 hsa_circ_001822 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2187 No 31026505 hsa_circ_000417 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2188 No 31026505 hsa_circ_004514 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2189 No 31026505 hsa_circ_005756 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2190 No 31026505 hsa_circ_002800 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2191 No 31026505 hsa_circ_004147 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2165 No 31026505 hsa_circ_006586 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2163 No 31026505 hsa_circ_000875 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2135 No 31026505 hsa_circ_003289 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2148 No 31026505 hsa_circ_000321 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2136 No 31026505 hsa_circ_005813 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2137 No 31026505 hsa_circ_006626 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2138 No 31026505 hsa_circ_005766 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2139 No 31026505 hsa_circ_004067 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2140 No 31026505 hsa_circ_000040 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2141 No 31026505 hsa_circ_007175 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2142 No 31026505 hsa_circ_000673 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2143 No 31026505 hsa_circ_005919 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2144 No 31026505 hsa_circ_004611 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2145 No 31026505 hsa_circ_006236 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2146 No 31026505 hsa_circ_000020 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2147 No 31026505 hsa_circ_000974 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2149 No 31026505 hsa_circ_006676 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2162 No 31026505 hsa_circ_004586 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2150 No 31026505 hsa_circ_006101 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2151 No 31026505 hsa_circ_001798 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2152 No 31026505 hsa_circ_005991 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2153 No 31026505 hsa_circ_003992 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2154 No 31026505 hsa_circ_000458 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2155 No 31026505 hsa_circ_006580 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2156 No 31026505 hsa_circ_002041 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2157 No 31026505 hsa_circ_003430 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2158 No 31026505 hsa_circ_006474 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2159 No 31026505 hsa_circ_003458 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2160 No 31026505 hsa_circ_004512 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2161 No 31026505 hsa_circ_007140 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2075 No 31026505 hsa_circ_005491 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2073 No 31026505 hsa_circ_003425 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1955 No 31026505 hsa_circ_000878 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1998 No 31026505 hsa_circ_003592 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1986 No 31026505 hsa_circ_004724 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1987 No 31026505 hsa_circ_000143 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1988 No 31026505 hsa_circ_004792 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1989 No 31026505 hsa_circ_002067 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1990 No 31026505 hsa_circ_006746 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1991 No 31026505 hsa_circ_000464 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1992 No 31026505 hsa_circ_004769 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1993 No 31026505 hsa_circ_000541 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1994 No 31026505 hsa_circ_001782 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1995 No 31026505 hsa_circ_004005 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1996 No 31026505 hsa_circ_005033 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1997 No 31026505 hsa_circ_004558 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1999 No 31026505 hsa_circ_004720 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1984 No 31026505 hsa_circ_004006 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2000 No 31026505 hsa_circ_006977 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2001 No 31026505 hsa_circ_003811 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2002 No 31026505 hsa_circ_000170 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2003 No 31026505 hsa_circ_001843 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2004 No 31026505 hsa_circ_000865 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2005 No 31026505 hsa_circ_002549 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2006 No 31026505 hsa_circ_005040 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2007 No 31026505 hsa_circ_005115 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2008 No 31026505 hsa_circ_004793 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2009 No 31026505 hsa_circ_000093 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2010 No 31026505 hsa_circ_007248 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2011 No 31026505 hsa_circ_006564 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1985 No 31026505 hsa_circ_007111 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1983 No 31026505 hsa_circ_001957 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2013 No 31026505 hsa_circ_001650 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1968 No 31026505 hsa_circ_003360 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1956 No 31026505 hsa_circ_006321 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1957 No 31026505 hsa_circ_004830 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1958 No 31026505 hsa_circ_003511 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1959 No 31026505 hsa_circ_002769 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1960 No 31026505 hsa_circ_002940 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1961 No 31026505 hsa_circ_003978 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1962 No 31026505 hsa_circ_006455 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1963 No 31026505 hsa_circ_003259 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1964 No 31026505 hsa_circ_005110 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1965 No 31026505 hsa_circ_000540 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1966 No 31026505 hsa_circ_002795 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1967 No 31026505 hsa_circ_001065 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1969 No 31026505 hsa_circ_003983 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1982 No 31026505 hsa_circ_000930 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1970 No 31026505 hsa_circ_003772 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1971 No 31026505 hsa_circ_001776 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1972 No 31026505 hsa_circ_003166 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1973 No 31026505 hsa_circ_004557 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1974 No 31026505 hsa_circ_006764 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1975 No 31026505 hsa_circ_000732 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1976 No 31026505 hsa_circ_002345 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1977 No 31026505 hsa_circ_003397 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1978 No 31026505 hsa_circ_001496 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1979 No 31026505 hsa_circ_006361 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1980 No 31026505 hsa_circ_003663 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1981 No 31026505 hsa_circ_003861 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2012 No 31026505 hsa_circ_000004 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2014 No 31026505 hsa_circ_003582 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2072 No 31026505 hsa_circ_002689 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2058 No 31026505 hsa_circ_004001 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2046 No 31026505 hsa_circ_003505 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2047 No 31026505 hsa_circ_001924 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2048 No 31026505 hsa_circ_001591 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2049 No 31026505 hsa_circ_005809 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2050 No 31026505 hsa_circ_004688 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2051 No 31026505 hsa_circ_004326 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2052 No 31026505 hsa_circ_005746 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2053 No 31026505 hsa_circ_004066 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2054 No 31026505 hsa_circ_003671 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2055 No 31026505 hsa_circ_003588 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2056 No 31026505 hsa_circ_003541 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2057 No 31026505 hsa_circ_005424 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2059 No 31026505 hsa_circ_003938 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2044 No 31026505 hsa_circ_000223 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2060 No 31026505 hsa_circ_003115 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2061 No 31026505 hsa_circ_005467 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2062 No 31026505 hsa_circ_001240 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2063 No 31026505 hsa_circ_001030 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2064 No 31026505 hsa_circ_006901 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2065 No 31026505 hsa_circ_000400 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2066 No 31026505 hsa_circ_000259 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2067 No 31026505 hsa_circ_003142 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2068 No 31026505 hsa_circ_003583 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2069 No 31026505 hsa_circ_005085 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2070 No 31026505 hsa_circ_004496 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2071 No 31026505 hsa_circ_007264 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2045 No 31026505 hsa_circ_004812 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2043 No 31026505 hsa_circ_000112 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2015 No 31026505 hsa_circ_005778 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2028 No 31026505 hsa_circ_005965 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2016 No 31026505 hsa_circ_004456 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2017 No 31026505 hsa_circ_000115 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2018 No 31026505 hsa_circ_004138 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2019 No 31026505 hsa_circ_003336 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2020 No 31026505 hsa_circ_000867 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2021 No 31026505 hsa_circ_003686 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2022 No 31026505 hsa_circ_000962 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2023 No 31026505 hsa_circ_006223 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2024 No 31026505 hsa_circ_004363 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2025 No 31026505 hsa_circ_001943 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2026 No 31026505 hsa_circ_000482 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2027 No 31026505 hsa_circ_006155 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2029 No 31026505 hsa_circ_003693 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2042 No 31026505 hsa_circ_001188 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2030 No 31026505 hsa_circ_003005 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2031 No 31026505 hsa_circ_002900 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2032 No 31026505 hsa_circ_006567 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2033 No 31026505 hsa_circ_004357 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2034 No 31026505 hsa_circ_006487 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2035 No 31026505 hsa_circ_000644 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2036 No 31026505 hsa_circ_005803 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2037 No 31026505 hsa_circ_003277 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2038 No 31026505 hsa_circ_001386 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2039 No 31026505 hsa_circ_003198 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2040 No 31026505 hsa_circ_004573 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2041 No 31026505 hsa_circ_002656 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2674 No 31026505 hsa_circ_001423 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2676 No 31026505 hsa_circ_001301 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3534 No 31026505 hsa_circ_006503 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3397 No 31026505 hsa_circ_000841 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3309 No 31026505 hsa_circ_004714 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3310 No 31026505 hsa_circ_005438 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3311 No 31026505 hsa_circ_004064 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3312 No 31026505 hsa_circ_001080 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3313 No 31026505 hsa_circ_004303 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3314 No 31026505 hsa_circ_001208 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3315 No 31026505 hsa_circ_004969 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3316 No 31026505 hsa_circ_005125 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3317 No 31026505 hsa_circ_005622 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3318 No 31026505 hsa_circ_000099 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3319 No 31026505 hsa_circ_003589 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3320 No 31026505 hsa_circ_007067 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3321 No 31026505 hsa_circ_000487 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3322 No 31026505 hsa_circ_002396 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3323 No 31026505 hsa_circ_000731 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3324 No 31026505 hsa_circ_000966 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3325 No 31026505 hsa_circ_007289 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3326 No 31026505 hsa_circ_001530 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3327 No 31026505 hsa_circ_005702 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3328 No 31026505 hsa_circ_002784 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3329 No 31026505 hsa_circ_003368 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3330 No 31026505 hsa_circ_000367 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3331 No 31026505 hsa_circ_000829 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3332 No 31026505 hsa_circ_000437 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3333 No 31026505 hsa_circ_001316 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3334 No 31026505 hsa_circ_002645 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3335 No 31026505 hsa_circ_003778 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3308 No 31026505 hsa_circ_002476 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3307 No 31026505 hsa_circ_003676 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3306 No 31026505 hsa_circ_004631 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3291 No 31026505 hsa_circ_002812 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3279 No 31026505 hsa_circ_006933 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3280 No 31026505 hsa_circ_007101 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3281 No 31026505 hsa_circ_006696 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3282 No 31026505 hsa_circ_001714 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3283 No 31026505 hsa_circ_003345 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3284 No 31026505 hsa_circ_002895 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3285 No 31026505 hsa_circ_003293 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3286 No 31026505 hsa_circ_003527 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3287 No 31026505 hsa_circ_006857 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3288 No 31026505 hsa_circ_005262 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3289 No 31026505 hsa_circ_002513 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3290 No 31026505 hsa_circ_006864 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3292 No 31026505 hsa_circ_001087 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3305 No 31026505 hsa_circ_000961 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3293 No 31026505 hsa_circ_000839 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3294 No 31026505 hsa_circ_002876 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3295 No 31026505 hsa_circ_006110 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3296 No 31026505 hsa_circ_000953 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3297 No 31026505 hsa_circ_001369 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3298 No 31026505 hsa_circ_007209 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3299 No 31026505 hsa_circ_005071 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3300 No 31026505 hsa_circ_000741 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3301 No 31026505 hsa_circ_000016 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3302 No 31026505 hsa_circ_003763 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3303 No 31026505 hsa_circ_003068 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3304 No 31026505 hsa_circ_002718 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3336 No 31026505 hsa_circ_000442 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3337 No 31026505 hsa_circ_004273 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3338 No 31026505 hsa_circ_004428 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3382 No 31026505 hsa_circ_001060 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3370 No 31026505 hsa_circ_007179 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3371 No 31026505 hsa_circ_004180 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3372 No 31026505 hsa_circ_000084 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3373 No 31026505 hsa_circ_002502 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3374 No 31026505 hsa_circ_004602 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3375 No 31026505 hsa_circ_005648 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3376 No 31026505 hsa_circ_006422 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3377 No 31026505 hsa_circ_002829 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3378 No 31026505 hsa_circ_000812 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3379 No 31026505 hsa_circ_001508 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3380 No 31026505 hsa_circ_000723 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3381 No 31026505 hsa_circ_002206 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3383 No 31026505 hsa_circ_004939 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3368 No 31026505 hsa_circ_003283 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3384 No 31026505 hsa_circ_000996 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3385 No 31026505 hsa_circ_005202 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3386 No 31026505 hsa_circ_006657 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3387 No 31026505 hsa_circ_002209 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3388 No 31026505 hsa_circ_000069 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3389 No 31026505 hsa_circ_000907 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3390 No 31026505 hsa_circ_001004 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3391 No 31026505 hsa_circ_005472 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3392 No 31026505 hsa_circ_000443 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3393 No 31026505 hsa_circ_002465 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3394 No 31026505 hsa_circ_005299 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3395 No 31026505 hsa_circ_003533 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3369 No 31026505 hsa_circ_006762 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3367 No 31026505 hsa_circ_005319 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3339 No 31026505 hsa_circ_001688 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3352 No 31026505 hsa_circ_000228 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3340 No 31026505 hsa_circ_002229 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3341 No 31026505 hsa_circ_006419 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3342 No 31026505 hsa_circ_004311 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3343 No 31026505 hsa_circ_001165 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3344 No 31026505 hsa_circ_001438 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3345 No 31026505 hsa_circ_002040 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3346 No 31026505 hsa_circ_004834 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3347 No 31026505 hsa_circ_006424 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3348 No 31026505 hsa_circ_004126 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3349 No 31026505 hsa_circ_004329 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3350 No 31026505 hsa_circ_005506 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3351 No 31026505 hsa_circ_000978 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3353 No 31026505 hsa_circ_002372 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3366 No 31026505 hsa_circ_001283 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3354 No 31026505 hsa_circ_006322 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3355 No 31026505 hsa_circ_001979 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3356 No 31026505 hsa_circ_004195 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3357 No 31026505 hsa_circ_001730 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3358 No 31026505 hsa_circ_001092 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3359 No 31026505 hsa_circ_006156 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3360 No 31026505 hsa_circ_002162 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3361 No 31026505 hsa_circ_002114 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3362 No 31026505 hsa_circ_002899 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3363 No 31026505 hsa_circ_006351 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3364 No 31026505 hsa_circ_004151 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3365 No 31026505 hsa_circ_001435 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3278 No 31026505 hsa_circ_006104 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3277 No 31026505 hsa_circ_001038 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3276 No 31026505 hsa_circ_002555 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3201 No 31026505 hsa_circ_004971 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3189 No 31026505 hsa_circ_004387 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3190 No 31026505 hsa_circ_003982 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3191 No 31026505 hsa_circ_005545 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3192 No 31026505 hsa_circ_007219 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3193 No 31026505 hsa_circ_006269 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3194 No 31026505 hsa_circ_004665 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3195 No 31026505 hsa_circ_004194 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3196 No 31026505 hsa_circ_001898 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3197 No 31026505 hsa_circ_004662 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3198 No 31026505 hsa_circ_000647 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3199 No 31026505 hsa_circ_005563 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3200 No 31026505 hsa_circ_005335 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3202 No 31026505 hsa_circ_004003 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3187 No 31026505 hsa_circ_005054 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3203 No 31026505 hsa_circ_004933 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3204 No 31026505 hsa_circ_006562 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3205 No 31026505 hsa_circ_006561 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3206 No 31026505 hsa_circ_000053 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3207 No 31026505 hsa_circ_000621 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3208 No 31026505 hsa_circ_000573 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3209 No 31026505 hsa_circ_003404 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3210 No 31026505 hsa_circ_007333 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3211 No 31026505 hsa_circ_003406 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3212 No 31026505 hsa_circ_005652 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3213 No 31026505 hsa_circ_003984 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3214 No 31026505 hsa_circ_004671 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3188 No 31026505 hsa_circ_003725 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3186 No 31026505 hsa_circ_002811 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3216 No 31026505 hsa_circ_001171 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3171 No 31026505 hsa_circ_001804 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3159 No 31026505 hsa_circ_000752 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3160 No 31026505 hsa_circ_004191 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3161 No 31026505 hsa_circ_003670 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3162 No 31026505 hsa_circ_005762 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3163 No 31026505 hsa_circ_006935 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3164 No 31026505 hsa_circ_004217 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3165 No 31026505 hsa_circ_007007 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3166 No 31026505 hsa_circ_001343 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3167 No 31026505 hsa_circ_000207 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3168 No 31026505 hsa_circ_000316 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3169 No 31026505 hsa_circ_004790 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3170 No 31026505 hsa_circ_001570 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3172 No 31026505 hsa_circ_005405 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3185 No 31026505 hsa_circ_006285 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3173 No 31026505 hsa_circ_002961 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3174 No 31026505 hsa_circ_005969 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3175 No 31026505 hsa_circ_005006 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3176 No 31026505 hsa_circ_000751 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3177 No 31026505 hsa_circ_004651 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3178 No 31026505 hsa_circ_001246 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3179 No 31026505 hsa_circ_000111 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3180 No 31026505 hsa_circ_003441 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3181 No 31026505 hsa_circ_006187 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3182 No 31026505 hsa_circ_004258 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3183 No 31026505 hsa_circ_006808 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3184 No 31026505 hsa_circ_006282 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3215 No 31026505 hsa_circ_001172 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3217 No 31026505 hsa_circ_001176 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3275 No 31026505 hsa_circ_002703 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3261 No 31026505 hsa_circ_005671 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3249 No 31026505 hsa_circ_004987 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3250 No 31026505 hsa_circ_002826 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3251 No 31026505 hsa_circ_005097 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3252 No 31026505 hsa_circ_000473 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3253 No 31026505 hsa_circ_002051 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3254 No 31026505 hsa_circ_004644 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3255 No 31026505 hsa_circ_000019 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3256 No 31026505 hsa_circ_004819 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3257 No 31026505 hsa_circ_006344 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3258 No 31026505 hsa_circ_006520 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3259 No 31026505 hsa_circ_003830 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3260 No 31026505 hsa_circ_007316 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3262 No 31026505 hsa_circ_001494 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3247 No 31026505 hsa_circ_006938 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3263 No 31026505 hsa_circ_004770 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3264 No 31026505 hsa_circ_002533 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3265 No 31026505 hsa_circ_003770 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3266 No 31026505 hsa_circ_007201 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3267 No 31026505 hsa_circ_006151 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3268 No 31026505 hsa_circ_005937 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3269 No 31026505 hsa_circ_004441 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3270 No 31026505 hsa_circ_006447 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3271 No 31026505 hsa_circ_004181 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3272 No 31026505 hsa_circ_001182 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3273 No 31026505 hsa_circ_001183 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3274 No 31026505 hsa_circ_003093 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3248 No 31026505 hsa_circ_001330 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3246 No 31026505 hsa_circ_002296 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3218 No 31026505 hsa_circ_001515 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3231 No 31026505 hsa_circ_007308 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3219 No 31026505 hsa_circ_003140 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3220 No 31026505 hsa_circ_001768 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3221 No 31026505 hsa_circ_002161 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3222 No 31026505 hsa_circ_002510 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3223 No 31026505 hsa_circ_000833 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3224 No 31026505 hsa_circ_001072 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3225 No 31026505 hsa_circ_000517 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3226 No 31026505 hsa_circ_006157 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3227 No 31026505 hsa_circ_003274 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3228 No 31026505 hsa_circ_005607 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3229 No 31026505 hsa_circ_004337 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3230 No 31026505 hsa_circ_000835 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3232 No 31026505 hsa_circ_001248 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3245 No 31026505 hsa_circ_007265 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3233 No 31026505 hsa_circ_005396 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3234 No 31026505 hsa_circ_004503 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3235 No 31026505 hsa_circ_002657 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3236 No 31026505 hsa_circ_003146 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3237 No 31026505 hsa_circ_001729 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3238 No 31026505 hsa_circ_005998 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3239 No 31026505 hsa_circ_004903 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3240 No 31026505 hsa_circ_001810 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3241 No 31026505 hsa_circ_005727 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3242 No 31026505 hsa_circ_004890 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3243 No 31026505 hsa_circ_003949 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3244 No 31026505 hsa_circ_001577 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3396 No 31026505 hsa_circ_005975 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3398 No 31026505 hsa_circ_004291 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2677 No 31026505 hsa_circ_002194 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3399 No 31026505 hsa_circ_004002 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3497 No 31026505 hsa_circ_003306 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3498 No 31026505 hsa_circ_002313 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3499 No 31026505 novel_circ_018711 CircRNA Mus musculus Autistic Disorder brain tissue Expression[highly expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 novel_circ_028696 CircRNA Mus musculus Autistic Disorder brain tissue Expression[highly expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 novel_circ_058403 CircRNA Mus musculus Autistic Disorder brain tissue Expression[highly expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 novel_circ_013547 CircRNA Mus musculus Autistic Disorder brain tissue Expression[highly expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 novel_circ_002576 CircRNA Mus musculus Autistic Disorder brain tissue Expression[highly expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 novel_circ_011355 CircRNA Mus musculus Autistic Disorder brain tissue Expression[highly expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 novel_circ_052619 CircRNA Mus musculus Autistic Disorder brain tissue Expression[highly expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 novel_circ_000430 CircRNA Mus musculus Autistic Disorder brain tissue Expression[highly expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 novel_circ_063340 CircRNA Mus musculus Autistic Disorder brain tissue Expression[highly expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 novel_circ_015779 CircRNA Mus musculus Autistic Disorder brain tissue Expression[highly expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 hsa_circ_0029426 CircRNA Homo sapiens Glioblastoma blood Expression[highly expressed] qRT-PCR Among the 14 candidates, circRNA, circNT5E, circFOXO3, circ_0001946, circ_0029426, circ-SHPRH, and circMMP12 were detected with increased levels in the training set. No 32425605 circHIPK3 CircRNA Mus musculus Cardiac Fibrosis heart tissues Interaction[sponging miR-29b-3p] RIP//FISH//Luciferase Report Assay//Transwell Assay//EdU Staining//IF No 30967276 hsa_circ_0001859 CircRNA Mus musculus Pulmonary Disease, Chronic Obstructive lung tissue Expression[lower expressed] qRT-PCR//FISH circRNA0001859 was downregulated in the lung tissue of mice after the three kinds of treatments (Cigarette smoke (CS)/NK alone or CS + NNK) for inducing COPD. No 33239003 circDcbld1 CircRNA Mus musculus Intimal Hyperplasia common carotid artery Interaction[Targeting miR-145-3p/Neuropilin-1] Western Blot//FISH//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay In vitro, the suppression of circDcbld1 in rat vascular smooth muscle cells (VSMCs) led the increase of contractile smooth muscle cell markers and the decrease of cell migration. In vivo, the injection of chemically modified circDcbld1 small interfering RNA (siRNA) lessened the formation of neointima in rat CCA after balloon injury. Further experiments proved that circDcbld1, as a competing endogenous RNA, interacted with miR-145-3p and upregulated the level of neuropilin-1 (Nrp1), thereby regulating the migration of VSMCs. In this study, we demonstrated a new mechanism by which circular RNA promotes intimal hyperplasia. We deem that intervention in the circDcbld1-miR-145-3p/Nrp1 pathway might be a feasible approach to alleviate the post-injury intimal hyperplasia. No 31778958 hsa_circ_0074026 CircRNA Homo sapiens Glioma GM tissues,cell lines (U87MG, U118, U251, and LN229) Interaction[miR-1304;ERBB4] CCK8//qRT-PCR//Wound Healing Assay//Transwell Assay The depletion of circ_0074026 can block cell growth, migration, invasion, and impel cell apoptosis in the LN229 cell line. However, ectopically expressed circ_0074026 caused the opposite effect in the U251 cell line. The following dual-luciferase reporter assay demonstrated that miR-1304 interacted with circ_0074026 and ERBB4 3'-UTR. Furthermore, the rescue assay indicated that circ_0074026 modulated ERBB4 to promote tumor progression by regulating miR-1304. Thus, a novel regulatory pathway may provide a new therapeutic target for patients with GM. No 31643077 circSHPRH CircRNA Homo sapiens Glioblastoma blood Expression[highly expressed] qRT-PCR Among the 14 candidates, circRNA, circNT5E, circFOXO3, circ_0001946, circ_0029426, circ-SHPRH, and circMMP13 were detected with increased levels in the training set. No 32425605 circMMP9 CircRNA Homo sapiens Glioblastoma blood Expression[highly expressed] qRT-PCR Among the 14 candidates, circRNA, circNT5E, circFOXO3, circ_0001946, circ_0029426, circ-SHPRH, and circMMP14 were detected with increased levels in the training set. No 32425605 novel_circ_0002569 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[highly expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 mmu_circ_0001379 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[highly expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 novel_circ_0003587 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 novel_circ_0002971 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 novel_circ_0002612 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 novel_circ_0002263 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 novel_circ_0002115 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 hsa_circ_002100 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3496 No 31026505 hsa_circ_000975 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3495 No 31026505 hsa_circ_001040 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3494 No 31026505 hsa_circ_001002 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3487 No 31026505 circDENND2A CircRNA Homo sapiens Glioma Interaction[sponging miR-625-5p] RNA Pull-Down//Wound Healing Assay//qPCR//FISH//Luciferase Report Assay//IHC//Transwell Assay In order to profile the hypoxia-associated circRNAs, we compared the differentially expressed circRNA profiles between glioma and normal tissues (GSE86202) [21] with the differentially expressed mRNA profiles in U87MG cells between hypoxia and normoxia (GSE45301) [22]. As shown in Fig. 1a, expression changes of 12 circRNAs in glioma tissues and their host genes in hypoxia were confirmed, suggesting potential hypoxia-associated circRNAs in glioma. Notably, the expression levels of only one circRNA (circDENND2A) and its host gene (DENND2A) were found to be upregulated. circDENND2A is required for the hypoxia-induced malignancy of glioma cells and functions by sponging miR-625-5p. No 30988674 hsa_circ_002016 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3483 No 31026505 hsa_circ_0074027 CircRNA Homo sapiens Glioblastoma glioblastoma tissues Regulation[miR-518a-5p/IL17RD signaling pathway ] qRT-PCR//Luciferase Report Assay Circ_0074027 expression was evidently upregulated in GBM tissue specimens and cells compared to the adjacent non-tumorous tissues and NHA, respectively. Our findings provide evidence that circ_0074027 plays an oncogenic role in GBM by regulating miR-518a-5p/IL17RD signaling. No 30738578 circZNF609 CircRNA Homo sapiens Glioma cell line Regulation[ CircZNF609/miR-134-5p/BTG-2 axis] CCK8//qRT-PCR//Wound Healing Assay//Luciferase Report Assay CircZNF609 was significantly upregulated in U251 and U87 cells and acted as an oncogene to promote cell proliferation and cell migration of glioma cell U251 and U87.Both BTG-2 and CircZNF609 are the direct targets of miR-134-5p, and their expression could be negatively regulated by miR-134-5p. No 31721211 novel_circ_061645 CircRNA Mus musculus Autistic Disorder brain tissue Expression[lower expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 hsa_circ_002014 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3484 No 31026505 circNT5E CircRNA Homo sapiens Glioblastoma blood Expression[highly expressed] qRT-PCR Among the 14 candidates, circRNA, circNT5E, circFOXO3, circ_0001946, circ_0029426, circ-SHPRH, and circMMP9 were detected with increased levels in the training set. No 32425605 novel_circ_012200 CircRNA Mus musculus Autistic Disorder brain tissue Expression[lower expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 novel_circ_018104 CircRNA Mus musculus Autistic Disorder brain tissue Expression[lower expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 hsa_circ_002013 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3485 No 31026505 circFOXO3 CircRNA Homo sapiens Glioblastoma blood Expression[highly expressed] qRT-PCR Among the 14 candidates, circRNA, circNT5E, circFOXO3, circ_0001946, circ_0029426, circ-SHPRH, and circMMP10 were detected with increased levels in the training set. No 32425605 hsa_circ_000154 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3486 No 31026505 hsa_circ_007322 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3488 No 31026505 hsa_circ_003150 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3493 No 31026505 novel_circ_000370 CircRNA Mus musculus Autistic Disorder brain tissue Expression[lower expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 novel_circ_065910 CircRNA Mus musculus Autistic Disorder brain tissue Expression[lower expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 novel_circ_001586 CircRNA Mus musculus Autistic Disorder brain tissue Expression[lower expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 hsa_circ_003930 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3489 No 31026505 novel_circ_056205 CircRNA Mus musculus Autistic Disorder brain tissue Expression[lower expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 novel_circ_022010 CircRNA Mus musculus Autistic Disorder brain tissue Expression[lower expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 hsa_circ_0001946 CircRNA Homo sapiens Glioblastoma blood Expression[highly expressed] qRT-PCR Among the 14 candidates, circRNA, circNT5E, circFOXO3, circ_0001946, circ_0029426, circ-SHPRH, and circMMP11 were detected with increased levels in the training set. No 32425605 hsa_circ_003242 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3490 No 31026505 novel_circ_066322 CircRNA Mus musculus Autistic Disorder brain tissue Expression[lower expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 novel_circ_014536 CircRNA Mus musculus Autistic Disorder brain tissue Expression[lower expressed] qPCR//RNA-seq The volcano plots of circRNAs are shown in Figure 2B. A total of 1,059 altered circRNAs were identified in the autism group, with 477 upregulated and 582 downregulated (GSE163904, Figure 2C, Table 1, and Supplementary Material). No 33679870 hsa_circ_003653 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3491 No 31026505 hsa_circ_001196 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3492 No 31026505 novel_circ_0002035 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 hsa_circ_006108 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3500 No 31026505 novel_circ_0001482 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 hsa_circ_007073 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3520 No 31026505 rno_circ_006869 CircRNA Mus musculus Cerebral Hemorrhage cerebral cortex Expression[highly expressed] qRT-PCR//Microarray To validate the expression of circRNA observed in microarray results, 3 up-regulated (rno_circRNA_006869, rno_circRNA_011054 and rno_circRNA_005098) and 3 down-regulated (rno_circRNA_012556, rno_circRNA_001430 and rno_circRNA_004782) circRNAs after ICH were selected to perform qRT-PCR. The expression level of 2 up-regulated (rno_circRNA_011054 and rno_circRNA_005098) and 1 down-regulated (rno_circRNA_012556) statistically altered after ICH compared with the sham groups and these results were consistent with the microarray data (Fig. 3). No 31610150 circARF3 CircRNA Mus musculus Adipose Inflammation preadipocyte Interaction[Targeting miR-103/TRAF3] qRT-PCR//Luciferase Report Assay//Western Blot Furthermore, we found that tumor necrosis factor receptor-associated factor 3 (TRAF3), as a miR-103 downstream target, mediates the functions of miR-103 in adipose inflammation. Overexpressing TRAF3 attenuated miR-103-induced inflammation by accelerating mitophagy. Moreover, we identified that circARF3 blocked miR-103 effects, which resulted in an increase in TRAF3 expression. TRAF3 restrained the nuclear factor κB (NF-κB)-signaling pathway, heightened mitophagy, and suppressed NLRP3 inflammasome activation ultimately. Our data showed that circARF3 acts as an endogenous miR-103 sponge to inhibit mitophagy-mediated adipose inflammation both in vitro and in vivo. These findings disclose a new regulatory pathway for adipose inflammation, which consists of circARF3, miR-103, and TRAF3. No 30623853 mmu_circ_39830 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[lower expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 mmu_circ_29948 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[lower expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_003871 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3513 No 31026505 mmu_circ_40509 CircRNA Mus musculus Non-alcoholic Fatty Liver Disease Liver tissues Expression[lower expressed] qRT-PCR//Microarray A total of 450 circRNAs were revealed to be dysregulated, with 298 circRNAs Expression[up-expression]regulated and 152 circRNAs downregulated in the NASH model mice. No 30720095 hsa_circ_005557 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3514 No 31026505 hsa_circ_006335 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3515 No 31026505 hsa_circ_001902 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3516 No 31026505 hsa_circ_001134 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3517 No 31026505 hsa_circ_000396 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3518 No 31026505 hsa_circ_006691 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3519 No 31026505 hsa_circ_002198 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3521 No 31026505 rno_circ_005098 CircRNA Mus musculus Cerebral Hemorrhage cerebral cortex Expression[highly expressed] qRT-PCR//Microarray To validate the expression of circRNA observed in microarray results, 3 up-regulated (rno_circRNA_006869, rno_circRNA_011054 and rno_circRNA_005098) and 3 down-regulated (rno_circRNA_012556, rno_circRNA_001430 and rno_circRNA_004782) circRNAs after ICH were selected to perform qRT-PCR. The expression level of 2 up-regulated (rno_circRNA_011054 and rno_circRNA_005098) and 1 down-regulated (rno_circRNA_012556) statistically altered after ICH compared with the sham groups and these results were consistent with the microarray data (Fig. 5). No 31610150 hsa_circ_002117 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3522 No 31026505 hsa_circ_004484 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3523 No 31026505 hsa_circ_001886 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3524 No 31026505 hsa_circ_005073 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3525 No 31026505 hsa_circ_002188 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3526 No 31026505 hsa_circ_005275 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3527 No 31026505 hsa_circ_005527 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3528 No 31026505 hsa_circ_004495 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3529 No 31026505 hsa_circ_000525 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3530 No 31026505 hsa_circ_003817 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3531 No 31026505 hsa_circ_004053 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3532 No 31026505 hsa_circ_006807 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3533 No 31026505 rno_circ_011054 CircRNA Mus musculus Cerebral Hemorrhage cerebral cortex Expression[highly expressed] qRT-PCR//Microarray To validate the expression of circRNA observed in microarray results, 3 up-regulated (rno_circRNA_006869, rno_circRNA_011054 and rno_circRNA_005098) and 3 down-regulated (rno_circRNA_012556, rno_circRNA_001430 and rno_circRNA_004782) circRNAs after ICH were selected to perform qRT-PCR. The expression level of 2 up-regulated (rno_circRNA_011054 and rno_circRNA_005098) and 1 down-regulated (rno_circRNA_012556) statistically altered after ICH compared with the sham groups and these results were consistent with the microarray data (Fig. 4). No 31610150 hsa_circ_003872 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3512 No 31026505 novel_circ_0001472 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 mmu_circ_0001058 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 novel_circ_0000999 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 novel_circ_0000517 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 novel_circ_0000137 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 mmu_circ_0001770 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 mmu_circ_0001747 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 mmu_circ_0001352 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 novel_circ_0003626 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 hsa_circ_004375 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3501 No 31026505 novel_circ_0003100 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 novel_circ_0002430 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 novel_circ_0001874 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 novel_circ_0001305 CircRNA Mus musculus Myocardial Reperfusion Injury Myocardial tissues Expression[lower expressed] qRT-PCR//circRNA-seq All dysregulated circRNAs are listed in Table 1. No 32596283 rno_circ_004782 CircRNA Mus musculus Cerebral Hemorrhage cerebral cortex Expression[lower expressed] qRT-PCR//Microarray To validate the expression of circRNA observed in microarray results, 3 up-regulated (rno_circRNA_006869, rno_circRNA_011054 and rno_circRNA_005098) and 3 down-regulated (rno_circRNA_012556, rno_circRNA_001430 and rno_circRNA_004782) circRNAs after ICH were selected to perform qRT-PCR. The expression level of 2 up-regulated (rno_circRNA_011054 and rno_circRNA_005098) and 1 down-regulated (rno_circRNA_012556) statistically altered after ICH compared with the sham groups and these results were consistent with the microarray data (Fig. 8). No 31610150 hsa_circ_002501 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3511 No 31026505 hsa_circ_005490 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3502 No 31026505 hsa_circ_002371 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3503 No 31026505 hsa_circ_006906 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3504 No 31026505 hsa_circ_004471 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3505 No 31026505 hsa_circ_001881 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3506 No 31026505 hsa_circ_002866 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3507 No 31026505 hsa_circ_006237 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3508 No 31026505 hsa_circ_002865 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3509 No 31026505 hsa_circ_003424 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3510 No 31026505 rno_circ_001430 CircRNA Mus musculus Cerebral Hemorrhage cerebral cortex Expression[lower expressed] qRT-PCR//Microarray To validate the expression of circRNA observed in microarray results, 3 up-regulated (rno_circRNA_006869, rno_circRNA_011054 and rno_circRNA_005098) and 3 down-regulated (rno_circRNA_012556, rno_circRNA_001430 and rno_circRNA_004782) circRNAs after ICH were selected to perform qRT-PCR. The expression level of 2 up-regulated (rno_circRNA_011054 and rno_circRNA_005098) and 1 down-regulated (rno_circRNA_012556) statistically altered after ICH compared with the sham groups and these results were consistent with the microarray data (Fig. 7). No 31610150 hsa_circ_0072309 CircRNA Homo sapiens Triple Negative Breast Neoplasms TNBC patients Expression(lower expressed) qRT-PCR//RNA-seq Next, we mapped the RBPs that interact with the top five downregulated circRNAs (hsa_circ_0072309, circ_0004365, circ_0006677, circ_0008599, and circ_0009043) and hsa_circ_0000479, resulting in a total of 16 RBPs, most of them being enriched to pathways related to cancer and gene regulation (e.g., AGO1/2, EIF4A3, ELAVL1, and PTBP1). Among the six circRNAs, hsa_circ_0072309 was the one that presented the most confidence results, being able to distinguish TNBC patients from controls with an AUC of 0.78 and 0.81, respectively. No 35805051 rno_circ_012556 CircRNA Mus musculus Cerebral Hemorrhage cerebral cortex Expression[lower expressed] qRT-PCR//Microarray To validate the expression of circRNA observed in microarray results, 3 up-regulated (rno_circRNA_006869, rno_circRNA_011054 and rno_circRNA_005098) and 3 down-regulated (rno_circRNA_012556, rno_circRNA_001430 and rno_circRNA_004782) circRNAs after ICH were selected to perform qRT-PCR. The expression level of 2 up-regulated (rno_circRNA_011054 and rno_circRNA_005098) and 1 down-regulated (rno_circRNA_012556) statistically altered after ICH compared with the sham groups and these results were consistent with the microarray data (Fig. 6). No 31610150 hsa_circ_002015 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3482 No 31026505 hsa_circ_0005198 CircRNA Homo sapiens Glioma glioma tissues,blood Expression[highly expressed] qRT-PCR Here, we demonstrated that circ_0005198 was considerably up-regulated in glioma tissues, serum samples and TMZ-resistant glioma cells. No 33316781 circKIAA0368 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC cells Interaction(miR-6838-5p and PCAF) qRT-PCR//Western Blot CircKIAA0368 was upregulated in NPC cells and could elevate HOXA10 expression by sponging miR-6838-5p. Furthermore, circKIAA0368 was unveiled to competitively bind to p300/CREB-binding protein-associated factor (PCAF) to repress acetylation and degradation of HOXA10 protein. No 35593126 hsa_circ_001500 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3433 No 31026505 XLOC_020366 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [highly expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 hsa_circ_000940 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3422 No 31026505 hsa_circ_006526 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3423 No 31026505 hsa_circ_006065 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3424 No 31026505 hsa_circ_006062 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3425 No 31026505 hsa_circ_001140 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3426 No 31026505 hsa_circ_005552 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3427 No 31026505 hsa_circ_004669 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3428 No 31026505 hsa_circ_003803 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3429 No 31026505 hsa_circ_001528 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3430 No 31026505 hsa_circ_000702 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3431 No 31026505 hsa_circ_001006 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3432 No 31026505 hsa_circ_003470 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3434 No 31026505 XLOC_024429 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [highly expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 hsa_circ_005534 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3435 No 31026505 hsa_circ_004900 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3436 No 31026505 hsa_circ_005203 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3437 No 31026505 hsa_circ_007332 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3438 No 31026505 hsa_circ_006173 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3439 No 31026505 hsa_circ_004037 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3440 No 31026505 hsa_circ_007055 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3441 No 31026505 hsa_circ_000847 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3442 No 31026505 hsa_circ_002284 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3443 No 31026505 hsa_circ_001840 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3444 No 31026505 hsa_circ_004595 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3445 No 31026505 hsa_circ_002864 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3446 No 31026505 XLOC_023394 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [highly expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 hsa_circ_002433 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3421 No 31026505 hsa_circ_002263 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3448 No 31026505 hsa_circ_003154 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3412 No 31026505 hsa_circ_005904 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3400 No 31026505 hsa_circ_005592 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3401 No 31026505 hsa_circ_003926 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3402 No 31026505 hsa_circ_005069 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3403 No 31026505 hsa_circ_006277 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3404 No 31026505 hsa_circ_000087 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3405 No 31026505 hsa_circ_000089 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3406 No 31026505 hsa_circ_002210 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3407 No 31026505 hsa_circ_006260 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3408 No 31026505 hsa_circ_005466 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3409 No 31026505 hsa_circ_005820 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3410 No 31026505 hsa_circ_000951 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3411 No 31026505 hsa_circ_005604 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3413 No 31026505 XLOC_026236 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [highly expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 hsa_circ_005819 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3414 No 31026505 hsa_circ_000355 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3415 No 31026505 hsa_circ_001076 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3416 No 31026505 hsa_circ_006688 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3417 No 31026505 hsa_circ_000721 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3418 No 31026505 hsa_circ_007168 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3419 No 31026505 hsa_circ_002711 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3420 No 31026505 XLOC_014961 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [lower expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 XLOC_006315 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [lower expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 XLOC_005361 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [lower expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 XLOC_002938 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [lower expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 XLOC_026492 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [highly expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 hsa_circ_005567 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3447 No 31026505 hsa_circ_002283 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3449 No 31026505 hsa_circ_003656 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3481 No 31026505 hsa_circ_0028007 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Expression[highly expressed] qRT-PCR//MTT Hsa_circ_0028007 expression was abnormally heightened within NPC tissues in comparison with matched non-tumor tissues (P < .05). Over-expressed hsa_circ_0028007 was strongly associated with advanced (III-IV) tumor stage, aggressive infiltration, and metastatic lymph nodes of NPC patients (P < .05). No 32524687 rno_circ_0009301 CircRNA Rattus norvegicus hypertension Aortic Vascular Tissues Expression [highly expressed] In Vivo Experiment//qRT-PCR//circRNA-seq Additionally, real-time RT-PCR analysis verified that downregulation of rno_circRNA_0009197, and upregulation of rno_circRNA_0005818, rno_circRNA_0005304, rno_circRNA_0005506, and rno_circRNA_0009301 were observed in aorta of SHR when compared with that of WKY rats. No 34988135 rno_circ_0005506 CircRNA Rattus norvegicus hypertension Aortic Vascular Tissues Expression [highly expressed] In Vivo Experiment//qRT-PCR//circRNA-seq Additionally, real-time RT-PCR analysis verified that downregulation of rno_circRNA_0009197, and upregulation of rno_circRNA_0005818, rno_circRNA_0005304, rno_circRNA_0005506, and rno_circRNA_0009301 were observed in aorta of SHR when compared with that of WKY rats. No 34988135 rno_circ_0005304 CircRNA Rattus norvegicus hypertension Aortic Vascular Tissues Expression [highly expressed] In Vivo Experiment//qRT-PCR//circRNA-seq Additionally, real-time RT-PCR analysis verified that downregulation of rno_circRNA_0009197, and upregulation of rno_circRNA_0005818, rno_circRNA_0005304, rno_circRNA_0005506, and rno_circRNA_0009301 were observed in aorta of SHR when compared with that of WKY rats. No 34988135 rno_circ_0005818 CircRNA Rattus norvegicus hypertension Aortic Vascular Tissues Expression [highly expressed] In Vivo Experiment//qRT-PCR//circRNA-seq Additionally, real-time RT-PCR analysis verified that downregulation of rno_circRNA_0009197, and upregulation of rno_circRNA_0005818, rno_circRNA_0005304, rno_circRNA_0005506, and rno_circRNA_0009301 were observed in aorta of SHR when compared with that of WKY rats. No 34988135 rno_circ_0009197 CircRNA Rattus norvegicus hypertension Aortic Vascular Tissues Expression [lower expressed] In Vivo Experiment//qRT-PCR//circRNA-seq Additionally, real-time RT-PCR analysis verified that downregulation of rno_circRNA_0009197, and upregulation of rno_circRNA_0005818, rno_circRNA_0005304, rno_circRNA_0005506, and rno_circRNA_0009301 were observed in aorta of SHR when compared with that of WKY rats. No 34988135 hsa_circ_000543 CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Expression[highly expressed] RIP//Luciferase Report Assay//PCR//Microarray We found that circRNA_000543 expression was upregulated in NPC tissues compared adjacent tissues No 30928094 hsa_circ_005740 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3467 No 31026505 hsa_circ_005693 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4039 No 31026505 hsa_circ_001001 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3468 No 31026505 hsa_circ_005894 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3469 No 31026505 circMYC CircRNA Homo sapiens Nasopharyngeal carcinoma exosomal Expression[highly expressed] qRT-PCR//Colony Formation Assay//EdU Staining Circulating exosomal circMYC was significantly increased in patients with NPC and was associated with tumor size, lymph node metastasis, TNM stage, survival rate, and disease recurrence. Circulating exosomal circMYC was significantly increased in patients with NPC and was associated with tumor size, lymph node metastasis, TNM stage, survival rate, and disease recurrence. No 32945062 hsa_circ_004367 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3470 No 31026505 hsa_circ_002602 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3471 No 31026505 circPTPN12 CircRNA Rattus norvegicus Endometrium Fibrosis EECs Regulation(circPTPN12/miR-21-5 p/∆Np63α pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RNA-seq//Luciferase Report Assay//IHC//Bioinformatics Analysis//IF Here, we provide the evidence that upregulation of circPTPN12 in endometrial epithelial cells (EECs) of fibrotic endometrium functions as endogenous sponge of miR-21-5 p to inhibit miR-21-5 p expression and activity, which in turn results in upregulation of ΔNp63α to induce the epithelial mesenchymal transition (EMT) of EECs (EEC-EMT). In a mouse model of endometrium fibrosis, circPTPN12 appears to be a cofactor of driving EEC-EMT and administration of miR-21-5 p could reverse this process and improve endometrial fibrosis. No 34132637 circHIPK3 CircRNA Mus musculus Cardiac Senescence CKO mice Regulation qRT-PCR//Co-IP//RIP//Western Blot Our novel CKO mice exhibited worse cardiac function, decreased circHIPK3 expression and telomere length shortening in the heart. In vitro, the level of p21 in CMs was significantly decreased by circHIPK3 overexpression, but increased by circHIPK3 silencing. We showed that circHIPK3 was a scaffold for p21 mRNA-binding protein HuR and E3 ubiquitin ligase β-TrCP. circHIPK3 silencing weakened the interaction between HuR and β-TrCP, reduced HuR ubiquitination, and enhanced the interaction between HuR and p21 mRNA. Moreover, we found that mice injected with human umbilical cord mesenchymal stem cell-derived exosomes (UMSC-Exos) showed increased circHIPK3 levels, decreased levels of p21, longer telomere length, and good cardiac function. However, these beneficial effects exerted by UMSC-Exos were inhibited by silencing circHIPK3. The level of the senescence-inducer p21 in the hearts of CKO mice was significantly increased and survival was poor compared with control mice. No 36438474 hsa_circ_001387 CircRNA Homo sapiens Nasopharyngeal carcinoma tumor tissues,blood , cell lines Expression[highly expressed] qRT-PCR Expression of hsa_circRNA_001387 was significantly increased in the tumor tissues of NPC surgical patients, in the peripheral blood samples of NPC radiotherapy patients and in the NPC cell lines (P<0.01). Expression of hsa_circRNA_001387 was significantly elevated in patients with well-differentiated tumors, lymph node metastasis and distant metastases, stage III-IV, positive EB virus, or family history of NPC. hsa_circRNA_001387 was closely associated with the prognosis of the patients. The overall survival and progression?-free survival were shorter in patients with high expression. No 32440159 hsa_circ_005514 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3472 No 31026505 circPITX1 CircRNA Homo sapiens Glioma glioma tissues and cells Expression[highly expressed] qRT-PCR Expression of circPITX1 and NEK2 was up-regulated in glioma tissues and cells. No 32190004 hsa_circ_006612 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3473 No 31026505 hsa_circ_001548 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3474 No 31026505 hsa_circ_006506 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3475 No 31026505 hsa_circ_004071 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3476 No 31026505 hsa_circ_003075 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3477 No 31026505 hsa_circ_005137 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3478 No 31026505 hsa_circ_006742 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3479 No 31026505 hsa_circ_006154 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3480 No 31026505 rno_circ_008646 CircRNA Rattus norvegicus Lung Injury lung tissues Interaction(rno-miR-224/FOXI1) In Vivo Experiment//qRT-PCR//Luciferase Report Assay//Western Blot Moreover, the expression of rno_circRNA_008646 was significantly higher in lung tissues of formaldehyde exposure rats than in control.Bioinformatics analysis showed that one potential target miRNA/mRNA for rno_circRNA_008646 was rno-miR-224/Forkhead Box I1 (FOXI1). Besides, luciferase report gene confirmed that there was targeted binding relationship between rno_circRNA_008646 and rno-miR-224, rno-miR-224 and FOXI1. Further verification experiments indicated that the expression of rno_circRNA_008646 was negatively correlated rno-miR-224, while it was positively correlated with FOXI1. No 35998475 hsa_circ_000078 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3466 No 31026505 hsa_circ_001709 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3450 No 31026505 hsa_circ_003654 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3455 No 31026505 hsa_circ_004211 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3451 No 31026505 hsa_circ_002262 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3452 No 31026505 XLOC_017727 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [highly expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 XLOC_007735 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [highly expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 XLOC_005533 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [highly expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 XLOC_003359 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [highly expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 hsa_circ_005917 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3453 No 31026505 hsa_circ_001994 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3454 No 31026505 XLOC_003353 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [highly expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 XLOC_001350 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [highly expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 XLOC_000409 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [highly expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 XLOC_000322 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [highly expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334 hsa_circ_005884 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3456 No 31026505 hsa_circ_002733 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3465 No 31026505 hsa_circ_005883 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3457 No 31026505 circSLC8A1 CircRNA Rattus norvegicus Heart Diseases myocardium Expression(circSlc8a1 level was upregulated, while the circNfix level was elevated) In Vivo Experiment//qRT-PCR//H&E Staining The results from both the IHD rat and H9c2 cell models revealed that circSlc8a1 level was upregulated, while the circNfix level was elevated in the early stage of ischemia and subsequently downregulated. The time-dependent expression patterns of the two circRNAs suggested their potential as SCD biomarkers. In autopsy cases, the results showed that the expression of these two circRNAs in the myocardium with acute IHD-related SCDs corresponded to the observations in the ischemic models. Further analysis related to myocardial ischemia indicated that circSLC8A1 showed high sensitivity and specificity for myocardial infarction and was positively correlated with creatine kinase MB in pericardial fluid. Downregulated circNFIX level could indicate the ischemic myocardial damage, and it was negatively correlated with the coronary artery stenosis grade. The combination of circSLC8A1 and circNFIX had better performance to discriminate IHD-related SCDs. The results suggested that circSLC8A1 and circNFIX may be used as auxiliary diagnostic markers for SCD caused by acute IHD in forensic medicine. Downregulated circNFIX level could indicate the ischemic myocardial damage, and it was negatively correlated with the coronary artery stenosis grade. No 33633191 circNFIX CircRNA Rattus norvegicus Heart Diseases myocardium Expression(circSlc8a1 level was upregulated, while the circNfix level was elevated) In Vivo Experiment//qRT-PCR//H&E Staining The results from both the IHD rat and H9c2 cell models revealed that circSlc8a1 level was upregulated, while the circNfix level was elevated in the early stage of ischemia and subsequently downregulated. The time-dependent expression patterns of the two circRNAs suggested their potential as SCD biomarkers. In autopsy cases, the results showed that the expression of these two circRNAs in the myocardium with acute IHD-related SCDs corresponded to the observations in the ischemic models. Further analysis related to myocardial ischemia indicated that circSLC8A1 showed high sensitivity and specificity for myocardial infarction and was positively correlated with creatine kinase MB in pericardial fluid. Downregulated circNFIX level could indicate the ischemic myocardial damage, and it was negatively correlated with the coronary artery stenosis grade. The combination of circSLC8A1 and circNFIX had better performance to discriminate IHD-related SCDs. The results suggested that circSLC8A1 and circNFIX may be used as auxiliary diagnostic markers for SCD caused by acute IHD in forensic medicine. Downregulated circNFIX level could indicate the ischemic myocardial damage, and it was negatively correlated with the coronary artery stenosis grade. No 33633191 hsa_circ_006978 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3458 No 31026505 hsa_circ_002204 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3459 No 31026505 hsa_circ_001992 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3460 No 31026505 circTLK1 CircRNA Homo sapiens Glioma glioma tumor tissues and glioma cell lines Interaction(miR-452-5p/SSR1 axis/PBX2/JAK/STAT signaling ) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//H&E Staining//Transwell Assay Our results revealed that circTLK1 is highly expressed in glioma tumor tissues and glioma cell lines. Mechanistically, investigation of the factors downstream of circTLK1 revealed that circTLK1 activated JAK/STAT signaling in glioma cells. Furthermore, AGO2-RIP, RNA-pull down, and luciferase reporter gene assays led to the identification of the novel circTLK1/miR-452-5p/SSR1 axis. Moreover, we investigated the upstream regulator of circTLK1 and found that circTLK1 expression in glioma cells could be regulated by the transcriptional factor PBX2. No 34721518 hsa_circ_005286 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3461 No 31026505 hsa_circ_0080229 CircRNA Homo sapiens Glioma glioma tissues and cell lines Interaction(miR-182/MDM2) Western Blot//ISH//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay The expression of circ_0080229 was upregulated in both glioma tissues and cell lines related to unfavorable clinicopathologic characteristics. The expression of circ_0080229 was found to be inversely correlated with miR-1827, a micro-ribonucleic acid (miRNA) targeting murine double minute-2 (MDM2). The downregulation of circ_0080229 inhibited gliomas in vivo and suppressed U87 and U251 cell lines in vitro, which the transfection of the miR-1827 inhibitor could reverse. Concerning the mechanism, a block of circ_0080229 decreased MDM2 expression, while the inhibition of miR-1827 reversed this effect. No 34268375 hsa_circ_000949 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3462 No 31026505 hsa_circ_004432 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3463 No 31026505 hsa_circ_001914 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3464 No 31026505 hsa_circ_000030 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3158 No 31026505 hsa_circ_004750 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3157 No 31026505 hsa_circ_004184 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3156 No 31026505 hsa_circ_001477 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3155 No 31026505 hsa_circ_004624 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2828 No 31026505 hsa_circ_000457 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2829 No 31026505 hsa_circ_000456 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2830 No 31026505 hsa_circ_005338 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2831 No 31026505 hsa_circ_002807 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2832 No 31026505 hsa_circ_003495 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2833 No 31026505 hsa_circ_004909 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2834 No 31026505 hsa_circ_002519 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2835 No 31026505 hsa_circ_005199 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2836 No 31026505 hsa_circ_000920 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2837 No 31026505 hsa_circ_000407 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2838 No 31026505 hsa_circ_002053 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2839 No 31026505 hsa_circ_006057 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2840 No 31026505 hsa_circ_000580 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2841 No 31026505 hsa_circ_004803 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2842 No 31026505 hsa_circ_005799 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2843 No 31026505 hsa_circ_004340 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2844 No 31026505 hsa_circ_000690 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2845 No 31026505 hsa_circ_001925 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2846 No 31026505 hsa_circ_004323 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2847 No 31026505 hsa_circ_000490 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2848 No 31026505 hsa_circ_000499 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2849 No 31026505 hsa_circ_002196 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2850 No 31026505 hsa_circ_005092 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2851 No 31026505 hsa_circ_004442 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2852 No 31026505 hsa_circ_000070 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2853 No 31026505 hsa_circ_006826 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2854 No 31026505 hsa_circ_002106 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2827 No 31026505 hsa_circ_002886 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2826 No 31026505 hsa_circ_003832 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2825 No 31026505 hsa_circ_005023 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2810 No 31026505 hsa_circ_004036 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2798 No 31026505 hsa_circ_004979 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2799 No 31026505 hsa_circ_003957 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2800 No 31026505 hsa_circ_002658 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2801 No 31026505 hsa_circ_000854 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2802 No 31026505 hsa_circ_004192 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2803 No 31026505 hsa_circ_002167 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2804 No 31026505 hsa_circ_006266 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2805 No 31026505 hsa_circ_006457 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2806 No 31026505 hsa_circ_002597 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2807 No 31026505 hsa_circ_004018 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2808 No 31026505 hsa_circ_001049 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2809 No 31026505 hsa_circ_005031 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2811 No 31026505 hsa_circ_002116 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2824 No 31026505 hsa_circ_000713 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2812 No 31026505 hsa_circ_000932 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2813 No 31026505 hsa_circ_000608 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2814 No 31026505 hsa_circ_001048 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2815 No 31026505 hsa_circ_003571 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2816 No 31026505 hsa_circ_001177 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2817 No 31026505 hsa_circ_001178 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2818 No 31026505 hsa_circ_006753 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2819 No 31026505 hsa_circ_005711 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2820 No 31026505 hsa_circ_001047 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2821 No 31026505 hsa_circ_001046 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2822 No 31026505 hsa_circ_006012 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2823 No 31026505 hsa_circ_007299 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2855 No 31026505 hsa_circ_002934 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2856 No 31026505 hsa_circ_004129 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2857 No 31026505 hsa_circ_000630 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2901 No 31026505 hsa_circ_002401 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2889 No 31026505 hsa_circ_000147 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2890 No 31026505 hsa_circ_000233 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2891 No 31026505 hsa_circ_002805 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2892 No 31026505 hsa_circ_001514 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2893 No 31026505 hsa_circ_004525 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2894 No 31026505 hsa_circ_004423 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2895 No 31026505 hsa_circ_004062 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2896 No 31026505 hsa_circ_003886 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2897 No 31026505 hsa_circ_007276 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2898 No 31026505 hsa_circ_002265 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2899 No 31026505 hsa_circ_000196 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2900 No 31026505 hsa_circ_000909 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2902 No 31026505 hsa_circ_003611 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2887 No 31026505 hsa_circ_001771 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2903 No 31026505 hsa_circ_005229 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2904 No 31026505 hsa_circ_000123 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2905 No 31026505 hsa_circ_005585 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2906 No 31026505 hsa_circ_001774 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2907 No 31026505 hsa_circ_002723 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2908 No 31026505 hsa_circ_000858 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2909 No 31026505 hsa_circ_003942 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2910 No 31026505 hsa_circ_006673 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2911 No 31026505 hsa_circ_001566 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2912 No 31026505 hsa_circ_004198 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2913 No 31026505 hsa_circ_002178 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2914 No 31026505 hsa_circ_006439 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2888 No 31026505 hsa_circ_002168 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2886 No 31026505 hsa_circ_003512 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2858 No 31026505 hsa_circ_001857 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2871 No 31026505 hsa_circ_005408 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2859 No 31026505 hsa_circ_006923 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2860 No 31026505 hsa_circ_002090 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2861 No 31026505 hsa_circ_005889 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2862 No 31026505 hsa_circ_000138 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2863 No 31026505 hsa_circ_004122 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2864 No 31026505 hsa_circ_004121 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2865 No 31026505 hsa_circ_005507 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2866 No 31026505 hsa_circ_006963 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2867 No 31026505 hsa_circ_004020 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2868 No 31026505 hsa_circ_003267 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2869 No 31026505 hsa_circ_004051 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2870 No 31026505 hsa_circ_004960 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2872 No 31026505 hsa_circ_002600 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2885 No 31026505 hsa_circ_002506 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2873 No 31026505 hsa_circ_001475 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2874 No 31026505 hsa_circ_005197 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2875 No 31026505 hsa_circ_000031 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2876 No 31026505 hsa_circ_000846 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2877 No 31026505 hsa_circ_003126 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2878 No 31026505 hsa_circ_001569 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2879 No 31026505 hsa_circ_001009 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2880 No 31026505 hsa_circ_005067 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2881 No 31026505 hsa_circ_002964 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2882 No 31026505 hsa_circ_006098 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2883 No 31026505 hsa_circ_001074 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2884 No 31026505 hsa_circ_005793 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2797 No 31026505 hsa_circ_001662 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2796 No 31026505 hsa_circ_004296 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2795 No 31026505 hsa_circ_001934 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2720 No 31026505 hsa_circ_006686 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2708 No 31026505 hsa_circ_003634 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2709 No 31026505 hsa_circ_002382 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2710 No 31026505 hsa_circ_003118 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2711 No 31026505 hsa_circ_003119 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2712 No 31026505 hsa_circ_004015 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2713 No 31026505 hsa_circ_006423 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2714 No 31026505 hsa_circ_003669 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2715 No 31026505 hsa_circ_000720 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2716 No 31026505 hsa_circ_001408 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2717 No 31026505 hsa_circ_005769 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2718 No 31026505 hsa_circ_003652 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2719 No 31026505 hsa_circ_002130 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2721 No 31026505 hsa_circ_003402 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2706 No 31026505 hsa_circ_006736 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2722 No 31026505 hsa_circ_003999 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2723 No 31026505 hsa_circ_003420 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2724 No 31026505 hsa_circ_002240 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2725 No 31026505 hsa_circ_002882 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2726 No 31026505 hsa_circ_007257 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2727 No 31026505 hsa_circ_002564 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2728 No 31026505 hsa_circ_000481 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2729 No 31026505 hsa_circ_000008 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2730 No 31026505 hsa_circ_000431 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2731 No 31026505 hsa_circ_002430 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2732 No 31026505 hsa_circ_000428 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2733 No 31026505 hsa_circ_003500 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2707 No 31026505 hsa_circ_000859 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2705 No 31026505 hsa_circ_001636 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2735 No 31026505 hsa_circ_003697 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2690 No 31026505 hsa_circ_003057 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2678 No 31026505 hsa_circ_006327 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2679 No 31026505 hsa_circ_002058 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2680 No 31026505 hsa_circ_001847 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2681 No 31026505 hsa_circ_001897 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2682 No 31026505 hsa_circ_003974 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2683 No 31026505 hsa_circ_001805 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2684 No 31026505 hsa_circ_002946 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2685 No 31026505 hsa_circ_002578 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2686 No 31026505 hsa_circ_004038 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2687 No 31026505 hsa_circ_000708 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2688 No 31026505 hsa_circ_001793 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2689 No 31026505 hsa_circ_004270 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2691 No 31026505 hsa_circ_006145 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2704 No 31026505 hsa_circ_001136 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2692 No 31026505 hsa_circ_006993 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2693 No 31026505 hsa_circ_003326 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2694 No 31026505 hsa_circ_005051 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2695 No 31026505 hsa_circ_004674 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2696 No 31026505 hsa_circ_005314 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2697 No 31026505 hsa_circ_004318 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2698 No 31026505 hsa_circ_001344 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2699 No 31026505 hsa_circ_005584 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2700 No 31026505 hsa_circ_006772 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2701 No 31026505 hsa_circ_006730 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2702 No 31026505 hsa_circ_003311 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2703 No 31026505 hsa_circ_000960 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2734 No 31026505 hsa_circ_003603 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2736 No 31026505 hsa_circ_002087 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2794 No 31026505 hsa_circ_002174 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2780 No 31026505 hsa_circ_003387 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2768 No 31026505 hsa_circ_004873 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2769 No 31026505 hsa_circ_003022 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2770 No 31026505 hsa_circ_003631 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2771 No 31026505 hsa_circ_002055 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2772 No 31026505 hsa_circ_000146 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2773 No 31026505 hsa_circ_004927 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2774 No 31026505 hsa_circ_001239 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2775 No 31026505 hsa_circ_000603 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2776 No 31026505 hsa_circ_001890 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2777 No 31026505 hsa_circ_001313 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2778 No 31026505 hsa_circ_002485 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2779 No 31026505 hsa_circ_004089 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2781 No 31026505 hsa_circ_005313 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2766 No 31026505 hsa_circ_005717 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2782 No 31026505 hsa_circ_007012 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2783 No 31026505 hsa_circ_004863 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2784 No 31026505 hsa_circ_004977 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2785 No 31026505 hsa_circ_002096 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2786 No 31026505 hsa_circ_002039 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2787 No 31026505 hsa_circ_001627 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2788 No 31026505 hsa_circ_002264 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2789 No 31026505 hsa_circ_004756 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2790 No 31026505 hsa_circ_006599 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2791 No 31026505 hsa_circ_000637 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2792 No 31026505 hsa_circ_004137 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2793 No 31026505 hsa_circ_003874 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2767 No 31026505 hsa_circ_001167 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2765 No 31026505 hsa_circ_006609 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2737 No 31026505 hsa_circ_002126 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2750 No 31026505 hsa_circ_004629 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2738 No 31026505 hsa_circ_001347 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2739 No 31026505 hsa_circ_005290 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2740 No 31026505 hsa_circ_001162 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2741 No 31026505 hsa_circ_003816 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2742 No 31026505 hsa_circ_001299 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2743 No 31026505 hsa_circ_005949 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2744 No 31026505 hsa_circ_000848 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2745 No 31026505 hsa_circ_001300 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2746 No 31026505 hsa_circ_003595 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2747 No 31026505 hsa_circ_002225 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2748 No 31026505 hsa_circ_002972 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2749 No 31026505 hsa_circ_007200 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2751 No 31026505 hsa_circ_001645 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2764 No 31026505 hsa_circ_005087 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2752 No 31026505 hsa_circ_002487 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2753 No 31026505 hsa_circ_005988 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2754 No 31026505 hsa_circ_006033 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2755 No 31026505 hsa_circ_006678 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2756 No 31026505 hsa_circ_003121 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2757 No 31026505 hsa_circ_003054 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2758 No 31026505 hsa_circ_000935 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2759 No 31026505 hsa_circ_001770 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2760 No 31026505 hsa_circ_003865 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2761 No 31026505 hsa_circ_006785 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2762 No 31026505 hsa_circ_002914 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2763 No 31026505 hsa_circ_002125 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2915 No 31026505 hsa_circ_005008 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2916 No 31026505 hsa_circ_000645 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2917 No 31026505 hsa_circ_005378 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3081 No 31026505 hsa_circ_004013 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3069 No 31026505 hsa_circ_004240 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3070 No 31026505 hsa_circ_005072 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3071 No 31026505 hsa_circ_004648 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3072 No 31026505 hsa_circ_004814 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3073 No 31026505 hsa_circ_006623 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3074 No 31026505 hsa_circ_004682 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3075 No 31026505 hsa_circ_005317 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3076 No 31026505 hsa_circ_003086 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3077 No 31026505 hsa_circ_003141 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3078 No 31026505 hsa_circ_005477 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3079 No 31026505 hsa_circ_000676 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3080 No 31026505 hsa_circ_006301 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3082 No 31026505 hsa_circ_004491 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3067 No 31026505 hsa_circ_003250 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3083 No 31026505 hsa_circ_001855 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3084 No 31026505 hsa_circ_006450 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3085 No 31026505 hsa_circ_003111 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3086 No 31026505 hsa_circ_000863 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3087 No 31026505 hsa_circ_007325 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3088 No 31026505 hsa_circ_002431 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3089 No 31026505 hsa_circ_006134 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3090 No 31026505 hsa_circ_006902 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3091 No 31026505 hsa_circ_003108 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3092 No 31026505 hsa_circ_002616 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3093 No 31026505 hsa_circ_000349 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3094 No 31026505 hsa_circ_006111 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3068 No 31026505 hsa_circ_000895 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3066 No 31026505 hsa_circ_000726 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3096 No 31026505 hsa_circ_004492 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3051 No 31026505 hsa_circ_000469 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3039 No 31026505 hsa_circ_006011 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3040 No 31026505 hsa_circ_006079 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3041 No 31026505 hsa_circ_001783 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3042 No 31026505 hsa_circ_004392 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3043 No 31026505 hsa_circ_003551 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3044 No 31026505 hsa_circ_000576 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3045 No 31026505 hsa_circ_005925 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3046 No 31026505 hsa_circ_002839 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3047 No 31026505 hsa_circ_000153 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3048 No 31026505 hsa_circ_001635 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3049 No 31026505 hsa_circ_000185 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3050 No 31026505 hsa_circ_000828 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3052 No 31026505 hsa_circ_000943 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3065 No 31026505 hsa_circ_001953 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3053 No 31026505 hsa_circ_004305 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3054 No 31026505 hsa_circ_005805 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3055 No 31026505 hsa_circ_002854 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3056 No 31026505 hsa_circ_006329 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3057 No 31026505 hsa_circ_001951 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3058 No 31026505 hsa_circ_002923 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3059 No 31026505 hsa_circ_002186 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3060 No 31026505 hsa_circ_004978 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3061 No 31026505 hsa_circ_003722 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3062 No 31026505 hsa_circ_003948 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3063 No 31026505 hsa_circ_000057 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3064 No 31026505 hsa_circ_003120 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3095 No 31026505 hsa_circ_007100 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3097 No 31026505 hsa_circ_000980 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3037 No 31026505 hsa_circ_007215 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3141 No 31026505 hsa_circ_002093 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3129 No 31026505 hsa_circ_002920 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3130 No 31026505 hsa_circ_007004 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3131 No 31026505 hsa_circ_005996 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3132 No 31026505 hsa_circ_000787 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3133 No 31026505 hsa_circ_006608 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3134 No 31026505 hsa_circ_003409 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3135 No 31026505 hsa_circ_005200 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3136 No 31026505 hsa_circ_004955 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3137 No 31026505 hsa_circ_005986 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3138 No 31026505 hsa_circ_006566 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3139 No 31026505 hsa_circ_003934 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3140 No 31026505 hsa_circ_004107 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3142 No 31026505 hsa_circ_004593 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3127 No 31026505 hsa_circ_004017 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3143 No 31026505 hsa_circ_002459 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3144 No 31026505 hsa_circ_006490 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3145 No 31026505 hsa_circ_003673 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3146 No 31026505 hsa_circ_006642 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3147 No 31026505 hsa_circ_004964 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3148 No 31026505 hsa_circ_005744 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3149 No 31026505 hsa_circ_006766 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3150 No 31026505 hsa_circ_002301 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3151 No 31026505 hsa_circ_002932 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3152 No 31026505 hsa_circ_003051 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3153 No 31026505 hsa_circ_000063 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3154 No 31026505 hsa_circ_005685 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3128 No 31026505 hsa_circ_007054 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3126 No 31026505 hsa_circ_000906 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3098 No 31026505 hsa_circ_005871 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3111 No 31026505 hsa_circ_001704 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3099 No 31026505 hsa_circ_001427 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3100 No 31026505 hsa_circ_001426 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3101 No 31026505 hsa_circ_003303 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3102 No 31026505 hsa_circ_004874 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3103 No 31026505 hsa_circ_005170 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3104 No 31026505 hsa_circ_001641 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3105 No 31026505 hsa_circ_000528 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3106 No 31026505 hsa_circ_006825 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3107 No 31026505 hsa_circ_000537 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3108 No 31026505 hsa_circ_006922 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3109 No 31026505 hsa_circ_000502 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3110 No 31026505 hsa_circ_005160 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3112 No 31026505 hsa_circ_002547 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3125 No 31026505 hsa_circ_000254 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3113 No 31026505 hsa_circ_003102 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3114 No 31026505 hsa_circ_000390 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3115 No 31026505 hsa_circ_006568 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3116 No 31026505 hsa_circ_007105 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3117 No 31026505 hsa_circ_001563 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3118 No 31026505 hsa_circ_005703 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3119 No 31026505 hsa_circ_006222 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3120 No 31026505 hsa_circ_003565 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3121 No 31026505 hsa_circ_001016 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3122 No 31026505 hsa_circ_006508 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3123 No 31026505 hsa_circ_004772 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3124 No 31026505 hsa_circ_006255 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3038 No 31026505 hsa_circ_006631 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3036 No 31026505 hsa_circ_000157 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2918 No 31026505 hsa_circ_000014 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2961 No 31026505 hsa_circ_003482 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2949 No 31026505 hsa_circ_000624 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2950 No 31026505 hsa_circ_001880 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2951 No 31026505 hsa_circ_005714 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2952 No 31026505 hsa_circ_001404 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2953 No 31026505 hsa_circ_003757 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2954 No 31026505 hsa_circ_004880 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2955 No 31026505 hsa_circ_005503 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2956 No 31026505 hsa_circ_000520 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2957 No 31026505 hsa_circ_001421 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2958 No 31026505 hsa_circ_003031 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2959 No 31026505 hsa_circ_003451 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2960 No 31026505 hsa_circ_004410 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2962 No 31026505 hsa_circ_006912 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2947 No 31026505 hsa_circ_002789 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2963 No 31026505 hsa_circ_001860 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2964 No 31026505 hsa_circ_001153 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2965 No 31026505 hsa_circ_005907 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2966 No 31026505 hsa_circ_000018 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2967 No 31026505 hsa_circ_000815 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2968 No 31026505 hsa_circ_006739 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2969 No 31026505 hsa_circ_002846 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2970 No 31026505 hsa_circ_003206 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2971 No 31026505 hsa_circ_006326 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2972 No 31026505 hsa_circ_000717 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2973 No 31026505 hsa_circ_005126 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2974 No 31026505 hsa_circ_002408 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2948 No 31026505 hsa_circ_005874 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2946 No 31026505 hsa_circ_004513 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2976 No 31026505 hsa_circ_001431 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2931 No 31026505 hsa_circ_005210 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2919 No 31026505 hsa_circ_005561 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2920 No 31026505 hsa_circ_004781 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2921 No 31026505 hsa_circ_006318 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2922 No 31026505 hsa_circ_001143 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2923 No 31026505 hsa_circ_005147 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2924 No 31026505 hsa_circ_005102 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2925 No 31026505 hsa_circ_005344 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2926 No 31026505 hsa_circ_000993 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2927 No 31026505 hsa_circ_005944 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2928 No 31026505 hsa_circ_003924 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2929 No 31026505 hsa_circ_000992 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2930 No 31026505 hsa_circ_005146 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2932 No 31026505 hsa_circ_003477 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2945 No 31026505 hsa_circ_005291 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2933 No 31026505 hsa_circ_007001 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2934 No 31026505 hsa_circ_006644 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2935 No 31026505 hsa_circ_004241 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2936 No 31026505 hsa_circ_002713 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2937 No 31026505 hsa_circ_002975 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2938 No 31026505 hsa_circ_002328 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2939 No 31026505 hsa_circ_000659 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2940 No 31026505 hsa_circ_004591 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2941 No 31026505 hsa_circ_004606 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2942 No 31026505 hsa_circ_002567 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2943 No 31026505 hsa_circ_006091 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2944 No 31026505 hsa_circ_006936 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2975 No 31026505 hsa_circ_004218 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2977 No 31026505 hsa_circ_006330 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3035 No 31026505 hsa_circ_001584 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3021 No 31026505 hsa_circ_003364 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3009 No 31026505 hsa_circ_004235 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3010 No 31026505 hsa_circ_005183 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3011 No 31026505 hsa_circ_004613 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3012 No 31026505 hsa_circ_002663 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3013 No 31026505 hsa_circ_005849 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3014 No 31026505 hsa_circ_005009 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3015 No 31026505 hsa_circ_006169 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3016 No 31026505 hsa_circ_000091 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3017 No 31026505 hsa_circ_004957 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3018 No 31026505 hsa_circ_002915 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3019 No 31026505 hsa_circ_005734 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3020 No 31026505 hsa_circ_003733 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3022 No 31026505 hsa_circ_001215 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3007 No 31026505 hsa_circ_000526 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3023 No 31026505 hsa_circ_003646 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3024 No 31026505 hsa_circ_006646 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3025 No 31026505 hsa_circ_002628 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3026 No 31026505 hsa_circ_003732 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3027 No 31026505 hsa_circ_007113 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3028 No 31026505 hsa_circ_001331 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3029 No 31026505 hsa_circ_006009 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3030 No 31026505 hsa_circ_006927 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3031 No 31026505 hsa_circ_006662 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3032 No 31026505 hsa_circ_007315 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3033 No 31026505 hsa_circ_007242 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3034 No 31026505 hsa_circ_003070 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3008 No 31026505 hsa_circ_001415 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3006 No 31026505 hsa_circ_006140 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2978 No 31026505 hsa_circ_006418 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2991 No 31026505 hsa_circ_000665 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2979 No 31026505 hsa_circ_000169 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2980 No 31026505 hsa_circ_001839 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2981 No 31026505 hsa_circ_002330 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2982 No 31026505 hsa_circ_000163 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2983 No 31026505 hsa_circ_006611 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2984 No 31026505 hsa_circ_000643 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2985 No 31026505 hsa_circ_001108 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2986 No 31026505 hsa_circ_006934 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2987 No 31026505 hsa_circ_004049 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2988 No 31026505 hsa_circ_005289 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2989 No 31026505 hsa_circ_002076 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2990 No 31026505 hsa_circ_001288 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2992 No 31026505 hsa_circ_000712 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3005 No 31026505 hsa_circ_004887 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2993 No 31026505 hsa_circ_004818 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2994 No 31026505 hsa_circ_002684 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2995 No 31026505 hsa_circ_005716 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2996 No 31026505 hsa_circ_005149 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2997 No 31026505 hsa_circ_002378 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2998 No 31026505 hsa_circ_003659 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.2999 No 31026505 hsa_circ_006319 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3000 No 31026505 hsa_circ_002911 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3001 No 31026505 hsa_circ_004552 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3002 No 31026505 hsa_circ_004061 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3003 No 31026505 hsa_circ_005353 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.3004 No 31026505 hsa_circ_0006719 CircRNA Homo sapiens Scoliosis blood Expression[highly expressed] circRNA-seq//qPCR Only hsa_circ_0006719 was confirmed to have a higher expression level in the CS group than the healthy control group (P = 0.036). No 32394619 hsa_circ_100352 LncRNA Homo sapiens Myelodysplastic Syndromes 100 MDS patients and 20 controls Expression [highly expressed] Bioinformatics Analysis Validated by real-time quantitative PCR between 100 MDS patients and 20 controls, three upregulated (hsa_circRNA_100352, hsa_circRNA_104056, and hsa_circRNA_104634) and three downregulated (hsa_circRNA_103846, hsa_circRNA_102817, and hsa_circRNA_102526) circRNAs matched the arrays. Kaplan-Meier survival analysis showed that only hsa_circRNA_100352, hsa_circRNA_104056, and hsa_circRNA_102817 were significantly associated with overall survival. No 33560542 hsa_circ_003688 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4040 No 31026505 hsa_circ_005881 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5520 No 31026505 hsa_circ_005029 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5522 No 31026505 hsa_circ_003475 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5523 No 31026505 hsa_circ_005649 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5524 No 31026505 hsa_circ_0008618 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A590) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S43). No 31700878 hsa_circ_002322 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5525 No 31026505 hsa_circ_0006530 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A589) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S42). No 31700878 hsa_circ_0003961 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A588) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S41). No 31700878 hsa_circ_0036423 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A587) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S40). No 31700878 hsa_circ_0008184 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A586) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S39). No 31700878 hsa_circ_0023179 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues, serum, and cells Regulation qRT-PCR hsa_circ_0023179 conforms to the basic properties of circRNA, and the detection method of hsa_circ_0023179 has good stability and repeatability. Its expression was connected to histological type, TNM stage, lymph node metastasis, and distal metastasis in NSCLC tissues, serum, and cells. hsa_circ_0023179 conforms to the basic properties of circRNA, and the detection method of hsa_circ_0023179 has good stability and repeatability. Its expression was connected to histological type, TNM stage, lymph node metastasis, and distal metastasis in NSCLC tissues, serum, and cells. No 35972691 hsa_circ_0003513 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A585) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S38). No 31700878 hsa_circ_006083 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6327 No 31026505 hsa_circ_0058764 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A584) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S37). No 31700878 hsa_circ_0001564 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A583) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S36). No 31700878 hsa_circ_0007883 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A582) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S35). No 31700878 hsa_circ_002605 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6326 No 31026505 hsa_circ_0001746 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A581) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S34). No 31700878 hsa_circ_004139 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5526 No 31026505 hsa_circ_000076 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5527 No 31026505 hsa_circ_004633 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5528 No 31026505 hsa_circ_0001868 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A580) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S33). No 31700878 hsa_circ_000492 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5529 No 31026505 hsa_circ_006500 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5530 No 31026505 hsa_circ_0008193 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A579) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S32). No 31700878 hsa_circ_0001550 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A578) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S31). No 31700878 hsa_circ_0006508 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A577) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S30). No 31700878 hsa_circ_004373 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5531 No 31026505 hsa_circ_004362 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5521 No 31026505 hsa_circ_003476 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5519 No 31026505 hsa_circ_000275 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5542 No 31026505 hsa_circ_0000119 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A591) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S44). No 31700878 hsa_circ_006613 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6330 No 31026505 hsa_circ_003304 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5506 No 31026505 hsa_circ_001263 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5507 No 31026505 hsa_circ_003891 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5508 No 31026505 hsa_circ_006016 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6329 No 31026505 hsa_circ_0087378 CircRNA Homo sapiens estrogen-receptor positive breast cancer ER-positive BC and adjacent nontumor tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq Additionally, hsa_circ_0087378 was validated to be Expression[down-expression]regulated in ER-positive BC and the hsa_circ_0087378-miR-1260b-SFRP1 axis was proposed to be a key regulatory pathway. No 30417652 hsa_circ_0000231 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A601) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S54). No 31700878 hsa_circ_005196 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5509 No 31026505 hsa_circ_0001487 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A600) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S53). No 31700878 hsa_circ_0004805 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A599) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S52). No 31700878 hsa_circ_001227 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5510 No 31026505 hsa_circ_0004592 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A598) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S51). No 31700878 hsa_circ_003191 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5511 No 31026505 hsa_circ_001818 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5512 No 31026505 hsa_circ_001672 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5513 No 31026505 hsa_circ_001370 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5514 No 31026505 hsa_circ_0001136 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A597) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S50). No 31700878 hsa_circ_0000213 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A596) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S49). No 31700878 hsa_circ_0091187 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A595) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S48). No 31700878 hsa_circ_0002457 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A594) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S47). No 31700878 hsa_circ_001258 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6328 No 31026505 hsa_circ_0004214 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A593) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S46). No 31700878 hsa_circ_006127 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5515 No 31026505 hsa_circ_001679 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5516 No 31026505 hsa_circ_004333 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5517 No 31026505 hsa_circ_0002901 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A592) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S45). No 31700878 hsa_circ_005691 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5518 No 31026505 hsa_circ_0001558 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A576) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S29). No 31700878 hsa_circ_0087960 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A575) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S28). No 31700878 hsa_circ_0001772 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A574) Expression[Expression[lower expressed]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S27). No 31700878 hsa_circ_0000638 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A573) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S26). No 31700878 hsa_circ_0075303 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A551) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S4). No 31700878 hsa_circ_001875 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5537 No 31026505 hsa_circ_007015 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6322 No 31026505 hsa_circ_001851 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5538 No 31026505 hsa_circ_0004983 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A550) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S3). No 31700878 hsa_circ_0017521 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A549) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S2). No 31700878 hsa_circ_006105 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5539 No 31026505 CBT15_circR_5906 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 41 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_179 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 40 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_3282 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 39 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_003972 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5540 No 31026505 hsa_circ_005425 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6321 No 31026505 CBT15_circR_3896 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 38 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_5592 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 37 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_006861 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6320 No 31026505 CBT15_circR_142 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 36 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_1967 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 35 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_3276 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 34 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_006937 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6319 No 31026505 CBT15_circR_2916 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 33 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_001472 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6318 No 31026505 CBT15_circR_3289 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 32 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_1983 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 31 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_3324 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 30 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_1779 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 29 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_005206 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6317 No 31026505 hsa_circ_003410 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6316 No 31026505 hsa_circ_003710 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5536 No 31026505 hsa_circ_000795 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5535 No 31026505 hsa_circ_0005939 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A552) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S5). No 31700878 hsa_circ_0009035 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A566) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S19). No 31700878 hsa_circ_0001460 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A572) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S25). No 31700878 hsa_circ_0001727 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A571) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S24). No 31700878 hsa_circ_005554 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5532 No 31026505 hsa_circ_002779 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5533 No 31026505 hsa_circ_004815 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5534 No 31026505 hsa_circ_0005332 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A570) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S23). No 31700878 hsa_circ_0001865 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A569) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S22). No 31700878 hsa_circ_0004692 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A568) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S21). No 31700878 hsa_circ_000646 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6325 No 31026505 hsa_circ_000512 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6324 No 31026505 hsa_circ_000322 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6323 No 31026505 hsa_circ_0003502 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A567) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S20). No 31700878 hsa_circ_0009143 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A565) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S18). No 31700878 hsa_circ_0076178 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A553) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S6). No 31700878 hsa_circ_0073608 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A564) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S17). No 31700878 circTTBK2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(miR-873-5p/TEAD1/DERL1 axis) In vivo experiment//Wound Healing Assay//qRT-PCR//Cell Proliferation Assay//IHC//Transwell Assay Overexpressed circTTBK2 in NSCLC tissues indicates poor prognosis of NSCLC patients. circTTBK2 harbors miR-873-5p, and miR-873-5p directly targets TEAD1. TEAD1 transcriptionally activates DERL1. Overexpressed circTTBK2 in NSCLC tissues indicates poor prognosis of NSCLC patients. No 35916080 hsa_circ_0001875 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A563) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S16). No 31700878 hsa_circ_0035292 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A562) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S15). No 31700878 hsa_circ_0072568 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A561) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S14). No 31700878 hsa_circ_0000615 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A560) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S13). No 31700878 hsa_circ_0002153 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A559) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S12). No 31700878 hsa_circ_0003692 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A558) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S11). No 31700878 hsa_circ_0005077 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A557) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S10). No 31700878 hsa_circ_0000344 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A556) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S9). No 31700878 hsa_circ_0011821 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A555) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S8). No 31700878 hsa_circ_0031749 CircRNA Homo sapiens Adenocarcinoma of Lung cell line (A554) Expression[Expression[Expression[highly expressed]-expression]-expression] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Transwell Assay CircRNAs were sequenced in A549 cells cultured under normoxia and hypoxia conditions. The Volcano plot filtered and identified the differentially expressed circRNAs with statistical significance between the two groExpression[Expression[up-expression]-expression]s (Figure 4A). The threshold of exhibiting folds change is 2.0 and P values <0.05. Among 65 identified circRNAs that were differentially expressed, 35 were Expression[Expression[up-expression]-expression]-regulated and 30 were Expression[down-expression]-regulated (Table S7). No 31700878 hsa_circ_0001492 CircRNA Homo sapiens Adenocarcinoma of Lung blood Expression[differently expression] qRT-PCR//RNA-seq//Western Blot The result of high-throughput sequencing data documented that 182 differentially expressed exosomal circRNAs in all were screened, which included 105 that were Expression[Expression[up-expression]-expression]regulated and 78 that were Expression[down-expression]regulated in LUAD patients plasma compared with controls. No 31646690 hsa_circ_0001346 CircRNA Homo sapiens Adenocarcinoma of Lung blood Expression[differently expression] qRT-PCR//RNA-seq//Western Blot The result of high-throughput sequencing data documented that 182 differentially expressed exosomal circRNAs in all were screened, which included 105 that were Expression[Expression[up-expression]-expression]regulated and 78 that were Expression[down-expression]regulated in LUAD patients plasma compared with controls. No 31646690 hsa_circ_0000690 CircRNA Homo sapiens Adenocarcinoma of Lung blood Expression[differently expression] qRT-PCR//RNA-seq//Western Blot The result of high-throughput sequencing data documented that 182 differentially expressed exosomal circRNAs in all were screened, which included 105 that were Expression[Expression[up-expression]-expression]regulated and 78 that were Expression[down-expression]regulated in LUAD patients plasma compared with controls. No 31646690 hsa_circ_14119-10 CircRNA Homo sapiens Essential Hypertension blood Expression[highly expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039987 (fold change in descending order). No 33236350 hsa_circ_007070 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5471 No 31026505 hsa_circ_0126640 CircRNA Homo sapiens Essential Hypertension blood Expression[lower expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039995 (fold change in descending order). No 33236350 hsa_circ_001272 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5472 No 31026505 hsa_circ_0097804 CircRNA Homo sapiens Essential Hypertension blood Expression[lower expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039994 (fold change in descending order). No 33236350 hsa_circ_002429 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5473 No 31026505 hsa_circ_0063886 CircRNA Homo sapiens Essential Hypertension blood Expression[lower expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039993 (fold change in descending order). No 33236350 hsa_circ_006728 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6348 No 31026505 hsa_circ_006363 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6347 No 31026505 hsa_circ_000803 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5474 No 31026505 hsa_circ_001102 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5475 No 31026505 hsa_circ_001023 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5476 No 31026505 hsa_circ_004660 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5477 No 31026505 hsa_circ_001166 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5478 No 31026505 hsa_circ_005864 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5479 No 31026505 hsa_circ_0131618 CircRNA Homo sapiens Essential Hypertension blood Expression[lower expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039992 (fold change in descending order). No 33236350 hsa_circ_0096334 CircRNA Homo sapiens Essential Hypertension blood Expression[lower expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039991 (fold change in descending order). No 33236350 hsa_circ_000436 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5480 No 31026505 hsa_circ_000027 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5481 No 31026505 hsa_circ_005591 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5482 No 31026505 hsa_circ_0093773 CircRNA Homo sapiens Essential Hypertension blood Expression[lower expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039990 (fold change in descending order). No 33236350 hsa_circ_005997 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6346 No 31026505 hsa_circ_003644 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5483 No 31026505 hsa_circ_000532 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5484 No 31026505 hsa_circ_004099 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5485 No 31026505 hsa_circ_0127342 CircRNA Homo sapiens Essential Hypertension blood Expression[lower expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039989 (fold change in descending order). No 33236350 hsa_circ_0100094 CircRNA Homo sapiens Essential Hypertension blood Expression[lower expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039988 (fold change in descending order). No 33236350 hsa_circ_005935 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5486 No 31026505 hsa_circ_004760 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5470 No 31026505 hsa_circ_8935-1 CircRNA Homo sapiens Essential Hypertension blood Expression[lower expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039996 (fold change in descending order). No 33236350 hsa_circ_000186 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5469 No 31026505 hsa_circ_003792 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5455 No 31026505 hsa_circ_000338 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5443 No 31026505 hsa_circ_003053 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5444 No 31026505 hsa_circ_005859 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5445 No 31026505 hsa_circ_005124 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5446 No 31026505 hsa_circ_002872 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5447 No 31026505 hsa_circ_006473 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5448 No 31026505 hsa_circ_005413 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5449 No 31026505 hsa_circ_000710 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5450 No 31026505 hsa_circ_005141 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5451 No 31026505 hsa_circ_002879 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5452 No 31026505 hsa_circ_001900 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5453 No 31026505 hsa_circ_000527 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5454 No 31026505 hsa_circ_002719 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5456 No 31026505 hsa_circ_000231 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5468 No 31026505 hsa_circ_006003 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5457 No 31026505 hsa_circ_001191 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5458 No 31026505 hsa_circ_007006 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5459 No 31026505 hsa_circ_007066 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5460 No 31026505 hsa_circ_005548 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5461 No 31026505 hsa_circ_002141 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5462 No 31026505 hsa_circ_002321 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5463 No 31026505 hsa_circ_001869 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5464 No 31026505 hsa_circ_006228 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5465 No 31026505 hsa_circ_0039978 CircRNA Homo sapiens Essential Hypertension blood Expression[lower expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039997 (fold change in descending order). No 33236350 hsa_circ_002898 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5466 No 31026505 hsa_circ_002948 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5467 No 31026505 hsa_circ_005151 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5487 No 31026505 hsa_circ_10088-9 CircRNA Homo sapiens Essential Hypertension blood Expression[highly expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039986 (fold change in descending order). No 33236350 hsa_circ_0001439 CircRNA Homo sapiens Adenocarcinoma of Lung blood Expression[differently expression] qRT-PCR//RNA-seq//Western Blot The result of high-throughput sequencing data documented that 182 differentially expressed exosomal circRNAs in all were screened, which included 105 that were Expression[Expression[up-expression]-expression]regulated and 78 that were Expression[down-expression]regulated in LUAD patients plasma compared with controls. No 31646690 hsa_circ_15285-1 CircRNA Homo sapiens Essential Hypertension blood Expression[highly expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039985 (fold change in descending order). No 33236350 hsa_circ_0011292 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Expression[highly expressed] qRT-PCR Circ_0011292 and TRIM65 were upregulated, while miR-379-5p was downregulated in NSCLC tissues and cells. No 32833503 hsa_circ_0000079 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[lower expressed] RNA Pull-Down//Co-IP//CCK8//qRT-PCR//RIP//Transwell Assay Our study showed that circ_0000079 (CiR79) levels were significantly downregulated in NSCLC patients. No 32951448 hsa_circ_000956 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6341 No 31026505 hsa_circ_104670 CircRNA Homo sapiens Sepsis sepsis serum exosomes Expression [highly expressed] qRT-PCR//Western Blot RT-qPCR verified the results of microarray analysis: hsa_circRNA_104484 and hsa_circRNA_104670 were upregulated in sepsis serum exosomes. ROC analysis showed that hsa_circRNA_104484 and hsa_circRNA_104670 in serum exosomes have the potential to be used as diagnostic markers for sepsis. No 34238972 hsa_circ_001014 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5500 No 31026505 hsa_circ_104484 CircRNA Homo sapiens Sepsis sepsis serum exosomes Expression [highly expressed] qRT-PCR//Western Blot RT-qPCR verified the results of microarray analysis: hsa_circRNA_104484 and hsa_circRNA_104670 were upregulated in sepsis serum exosomes. ROC analysis showed that hsa_circRNA_104484 and hsa_circRNA_104670 in serum exosomes have the potential to be used as diagnostic markers for sepsis. No 34238972 circPRKCI CircRNA Homo sapiens Sepsis blood Expression[lower expressed] qRT-PCR Decreased circ-PRKCI expression and increased miR-545 expression were observed in sepsis patients compared to HCs, both of which had close correlations with sepsis risk. No 32985287 hsa_circ_000773 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6340 No 31026505 hsa_circ_0054633 CircRNA Homo sapiens Diabetes, Gestational blood Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR Hsa_cirRNA_0054633 was highly correlated with GHBA1 and GHBA1c levels in maternal blood samples at various stages of the GDM groExpression[Expression[up-expression]-expression] (including placental tissue and umbilical cord blood) (P < 0.05). No 30736847 hsa_circ_003537 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6339 No 31026505 hsa_circ_000623 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6338 No 31026505 hsa_circ_002307 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5501 No 31026505 hsa_circ_007034 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6337 No 31026505 hsa_circ_005416 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5502 No 31026505 hsa_circ_006241 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6336 No 31026505 hsa_circ_005811 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5503 No 31026505 hsa_circ_004220 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6335 No 31026505 hsa_circ_0001789 CircRNA Homo sapiens stomach carcinoma GC tissues and plasma samples Expression(lower expressed) qRT-PCR GC tissues and plasma samples showed down-regulated hsa_circ_0001789 levels than their counterparts, which were closely correlated with the malignant characteristics of GC. hsa_circ_0001789 had preferred AUCs that reached 0.786 for predicting the stage of invasion, 0.603 for predicting the stage of lymphatic metastasis, 0.722 for predicting the stage of distant metastasis, and 0.786 for predicting TNM stage. No 36111683 hsa_circ_005875 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5504 No 31026505 hsa_circ_006166 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6334 No 31026505 circNRIP1 CircRNA Homo sapiens stomach carcinoma GC cells Expression[highly expressed] qRT-PCR//Western Blot circNRIP1 was upregulated in GC cells. No 32425596 hsa_circ_003602 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6333 No 31026505 hsa_circ_001259 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5505 No 31026505 hsa_circ_004287 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6332 No 31026505 hsa_circ_001376 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6331 No 31026505 hsa_circ_008068 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD cancer tissues Expression(highly expressed) qRT-PCR//Microarray Q-PCR results showed that hsa_circ_101555 and hsa_circ_008068 were significantly upregulated in both LUAD cancer tissues and circulating plasma. Hsa_circ_101555 and hsa_circ_008068 were positively associated with tumour differentiation, tumour size and CEA (P<0.05). No 35707741 hsa_circ_101555 CircRNA Homo sapiens Adenocarcinoma of Lung LUAD cancer tissues Expression(highly expressed) qRT-PCR//Microarray Q-PCR results showed that hsa_circ_101555 and hsa_circ_008068 were significantly upregulated in both LUAD cancer tissues and circulating plasma. Hsa_circ_101555 and hsa_circ_008068 were positively associated with tumour differentiation, tumour size and CEA (P<0.05). No 35707741 hsa_circ_003849 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5499 No 31026505 hsa_circ_001959 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5498 No 31026505 circMALAT1 CircRNA Homo sapiens Liver Neoplasms HCC tissues Expression[highly expressed] qRT-PCR//RIP//Western Blot Circ-MALAT1 is highly expressed in CSCs from clinical hepatocellular carcinoma samples under the mediation of an RNA-binding protein, AUF1. No 32099751 hsa_circ_0037909 CircRNA Homo sapiens Essential Hypertension blood Expression[highly expressed] qRT-PCR The expression level of hsa_circ_0037909 in EH patients was significantly higher than that in the healthy controls (P = 0.007), and the expression level of hsa-miR-637 in EH patients was significantly lower in than that in the healthy controls (P = 0.039); the same result appears in the HAECs and HUVECs. No 30861600 hsa_circ_0007075 CircRNA Homo sapiens Essential Hypertension blood Expression[highly expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039984 (fold change in descending order). No 33236350 hsa_circ_0117886 CircRNA Homo sapiens Essential Hypertension blood Expression[highly expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039983 (fold change in descending order). No 33236350 hsa_circ_13649-1 CircRNA Homo sapiens Essential Hypertension blood Expression[highly expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039982 (fold change in descending order). No 33236350 hsa_circ_0079536 CircRNA Homo sapiens Essential Hypertension blood Expression[highly expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039981 (fold change in descending order). No 33236350 hsa_circ_14116-3 CircRNA Homo sapiens Essential Hypertension blood Expression[highly expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039980 (fold change in descending order). No 33236350 hsa_circ_0133228 CircRNA Homo sapiens Essential Hypertension blood Expression[highly expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039979 (fold change in descending order). No 33236350 hsa_circ_0014243 CircRNA Homo sapiens Essential Hypertension blood Expression[highly expressed] qRT-PCR//Microarray The top 10 up-regulated circRNAs in the EH group were hsa_circ_0014243, hsa_circ_0133228, hsa-circRNA14116-3, hsa_circ_0079536, hsa-circRNA13649-1, hsa_circ_0117886, hsa_circ_0007075, hsa-circRNA15285-1, hsa-circRNA10088-9, and hsa-circRNA14119-10; the top 10 down-regulated circRNAs were hsa_circ_0100094, hsa_circ_0127342, hsa_circ_0093773, hsa_circ_0096334, hsa_circ_0131618, hsa_circ_0063886, hsa_circ_0097804, hsa_circ_0126640, hsa-circRNA8935-1, and hsa_circ_0039978 (fold change in descending order). No 33236350 hsa_circ_004505 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5488 No 31026505 hsa_circ_002887 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5489 No 31026505 hsa_circ_0037897 CircRNA Homo sapiens Essential Hypertension blood Expression[highly expressed] qRT-PCR The expression level of hsa_circ_0037897 in EH patients was significantly higher (p < .001) compared to the control group, while hsa-miR-145-5p had significantly lower expression(p = .002) than the control group. No 33307836 hsa_circ_001295 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5490 No 31026505 hsa_circ_002269 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5491 No 31026505 hsa_circ_0014243 CircRNA Homo sapiens Essential Hypertension blood Expression[highly expressed] qRT-PCR The results indicated that hsa_circ_0014243 was upregulated in whole blood samples of EH patients compared with that in the controls (P<0.001). No 30783441 hsa_circ_003906 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5497 No 31026505 hsa_circ_0126991 CircRNA Homo sapiens Essential Hypertension blood Expression[Expression[highly expressed]-expression] qRT-PCR//Microarray The expression level of hsa_circ_0126991 in EH patients was significantly higher in comparison with healthy controls (p < 0.0001). No 31108493 hsa_circ_0067127 CircRNA Homo sapiens Carcinoma, Hepatocellular PHC tissues Expression[lower expressed] qRT-PCR . The results indicated that hsa_circ_0003056 exhibited reduced expression in PHC tissues. Moreover, hsa_circ_0003056 and hsa_circ_0067127 were quantified in the plasma samples of 35 PHC patients and 32 healthy donors. The results revealed that hsa_circ_0067128 was significantly Expression[down-expression]regulated in the patients' plasma. No 31612035 hsa_circ_0003056 CircRNA Homo sapiens Carcinoma, Hepatocellular PHC tissues Expression[lower expressed] qRT-PCR . The results indicated that hsa_circ_0003056 exhibited reduced expression in PHC tissues. Moreover, hsa_circ_0003056 and hsa_circ_0067127 were quantified in the plasma samples of 35 PHC patients and 32 healthy donors. The results revealed that hsa_circ_0067127 was significantly Expression[down-expression]regulated in the patients' plasma. No 31612035 hsa_circ_007297 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5492 No 31026505 hsa_circ_000965 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5493 No 31026505 hsa_circ_005724 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6345 No 31026505 hsa_circ_006542 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6344 No 31026505 hsa_circ_000036 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6343 No 31026505 hsa_circ_000535 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5494 No 31026505 hsa_circ_006207 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5495 No 31026505 hsa_circ_004928 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5496 No 31026505 hsa_circ_004901 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6342 No 31026505 hsa_circ_005564 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5541 No 31026505 hsa_circ_006859 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6315 No 31026505 hsa_circ_000944 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5661 No 31026505 hsa_circ_0012342 CircRNA Homo sapiens Carcinoma, Mucoepidermoid MEC tissues Expression[Expression[lower expressed]-expression] qRT-PCR//Microarray We found hsa_circ_0012342 expression pattern was consistent with the microarray data and showed the highest fold change in MEC groExpression[Expression[up-expression]-expression] compared with normal control groExpression[Expression[up-expression]-expression] (Fig. 4B). No 30471855 hsa_circ_004498 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6301 No 31026505 hsa_circ_005489 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5623 No 31026505 hsa_circ_002692 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5624 No 31026505 hsa_circ_001205 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6300 No 31026505 hsa_circ_001385 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6299 No 31026505 hsa_circ_005525 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5625 No 31026505 hsa_circ_006821 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5626 No 31026505 circTtc3 CircRNA Homo sapiens Myocardial Infarction cell lines Interaction[sponging miR-15b] qRT-PCR Herein, we found that circ-Ttc3 was markedly upregulated in the ischemic myocardium and the cardiomyocytes subjected to hypoxic insult.Thus, our findings revealed the cardioprotective role of circ-Ttc3 in MI. The miR-15b-Arl2 regulatory cascade underlies the protection against MI-induced cardiomyocyte apoptosis by circ-Ttc3. No 30876857 hsa_circ_005516 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6298 No 31026505 hsa_circ_000165 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5627 No 31026505 hsa_circ_005581 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5628 No 31026505 hsa_circ_003599 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5629 No 31026505 hsa_circ_004068 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5630 No 31026505 hsa_circ_002323 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5631 No 31026505 hsa_circ_002191 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5632 No 31026505 hsa_circ_004689 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5633 No 31026505 hsa_circ_002064 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5634 No 31026505 hsa_circ_002333 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6297 No 31026505 hsa_circ_005079 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5635 No 31026505 hsa_circ_003715 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6296 No 31026505 hsa_circ_002102 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5636 No 31026505 hsa_circ_001970 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5637 No 31026505 hsa_circ_101692 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .156) were identified No 31261542 hsa_circ_083127 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .155) were identified No 31261542 hsa_circ_005790 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5638 No 31026505 hsa_circ_101153 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .154) were identified No 31261542 hsa_circ_004676 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5639 No 31026505 hsa_circ_004405 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6302 No 31026505 circPAX5 CircRNA Homo sapiens Precursor Cell Lymphoblastic Leukemia-Lymphoma peripheral blood Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR Starting from this resource of circRNA expression in mature blood cell populations, targeted examination identified striking and generalized Expression[Expression[up-expression]-expression]regulated expression of circPAX5, circPVT1 and circHIPK3 in pediatric B-precursor acute lymphoblastic leukemia, and disclosed circRNAs with variable expression across cytogenetic subtypes. No 31605010 CBT15_circR_1782 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 28 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_000505 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6303 No 31026505 hsa_circ_006833 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5604 No 31026505 hsa_circ_006256 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5605 No 31026505 hsa_circ_007331 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5606 No 31026505 hsa_circ_102685 CircRNA Homo sapiens Crohn Disease colon tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//Microarray Furthermore, circRNA-102685 was Expression[Expression[up-expression]-expression]regulated by 3.02-fold in the CD groExpression[Expression[up-expression]-expression] as compared with the control groExpression[Expression[up-expression]-expression] (P<0.01). According to the results of RT-qPCR validation, circRNA-102685 was Expression[Expression[up-expression]-expression]regulated by 1.46-fold in the CD groExpression[Expression[up-expression]-expression] as compared with the control groExpression[Expression[up-expression]-expression] (P<0.01; Fig. 2). No 30896837 circOGDH CircRNA Homo sapiens Ischemic Stroke penumbra tissue of middle cerebral artery occlusion mice and in the plasma of 45 patients with AIS Interaction( miR-5112/COL4A4 ) ISH//RIP//qPCR//Luciferase Report Assay CircOGDH expression was dramatically and selectively upregulated in the penumbra tissue of middle cerebral artery occlusion mice and in the plasma of 45 patients with AIS showing a 54-fold enhancement versus noncerebrovascular disease controls. Sequestering of miR-5112 by CircOGDH enhanced COL4A4 expression to elevate neuron damage. Additionally, knockdown of CircOGDH significantly enhanced neuronal cell viability under ischemic conditions. Furthermore, the expression of CircOGDH in brain tissue was closely related to that in the serum of middle cerebral artery occlusion mice. Finally, we found that CircOGDH was highly expressed in plasma exosomes of patients with AIS compared with those in noncerebrovascular disease individuals. Partial regression analysis revealed that CircOGDH expression was positively correlated with the size of penumbra in patients with AIS. No 35189704 hsa_circ_001962 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5607 No 31026505 hsa_circ_006179 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5608 No 31026505 hsa_circ_000849 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5609 No 31026505 hsa_circ_006900 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5610 No 31026505 circSCMH1 CircRNA Homo sapiens Ischemic Stroke blood Expression[lower expressed] qRT-PCR CircSCMH1 levels were significantly decreased in the plasma of patients with acute ischemic stroke, offering significant power in predicting stroke outcomes. CircSCMH1 levels were significantly decreased in the plasma of patients with acute ischemic stroke, offering significant power in predicting stroke outcomes. No 32441115 hsa_circ_0141720 CircRNA Homo sapiens Ischemic Stroke blood Expression[highly expressed] qRT-PCR//Microarray RT-PCR validated that the expression of hsa_circ_0141720 in serum of ACI patients was increased the most. No 32776759 hsa_circ_000496 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5611 No 31026505 hsa_circ_000984 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5612 No 31026505 hsa_circ_000585 CircRNA Homo sapiens Cholangiocarcinoma CCA tissues Expression [highly expressed] qRT-PCR//Microarray CircRNA_000585 was shown by qRT-PCR to be upregulated in tumour versus paired para-cancer tissue from 15 patients with CCA. No 34182814 hsa_circ_002559 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6304 No 31026505 hsa_circ_000523 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5613 No 31026505 hsa_circ_006024 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5614 No 31026505 hsa_circ_002192 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5615 No 31026505 hsa_circ_000955 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5616 No 31026505 hsa_circ_005271 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5617 No 31026505 circHIPK3 CircRNA Homo sapiens Precursor Cell Lymphoblastic Leukemia-Lymphoma peripheral blood Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR Starting from this resource of circRNA expression in mature blood cell populations, targeted examination identified striking and generalized Expression[Expression[up-expression]-expression]regulated expression of circPAX5, circPVT1 and circHIPK5 in pediatric B-precursor acute lymphoblastic leukemia, and disclosed circRNAs with variable expression across cytogenetic subtypes. No 31605012 hsa_circ_004511 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5618 No 31026505 circPVT1 CircRNA Homo sapiens Precursor Cell Lymphoblastic Leukemia-Lymphoma peripheral blood Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR Starting from this resource of circRNA expression in mature blood cell populations, targeted examination identified striking and generalized Expression[Expression[up-expression]-expression]regulated expression of circPAX5, circPVT1 and circHIPK4 in pediatric B-precursor acute lymphoblastic leukemia, and disclosed circRNAs with variable expression across cytogenetic subtypes. No 31605011 hsa_circ_004149 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5619 No 31026505 hsa_circ_000007 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5620 No 31026505 hsa_circ_001173 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5621 No 31026505 hsa_circ_007279 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5622 No 31026505 hsa_circ_001601 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5640 No 31026505 hsa_circ_003264 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5641 No 31026505 hsa_circ_006320 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5642 No 31026505 hsa_circ_004919 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5643 No 31026505 hsa_circ_003436 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5651 No 31026505 hsa_circ_007315 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .143) were identified No 31261542 hsa_circ_102606 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .142) were identified No 31261542 hsa_circ_101015 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .141) were identified No 31261542 hsa_circ_104864 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .140) were identified No 31261542 hsa_circ_103672 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .139) were identified No 31261542 hsa_circ_404660 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .138) were identified No 31261542 hsa_circ_056670 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .137) were identified No 31261542 hsa_circ_405133 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .136) were identified No 31261542 hsa_circ_0044234 CircRNA Homo sapiens Triple Negative Breast Neoplasms various BC subtypes as well as cell lines Interaction(miR135b-5p/GATA3 ceRNA axis) qRT-PCR Our experimental investigation of circ_0044234 expressions in various BC subtypes as well as cell lines reveals that TNBC expresses circ_0044234 at a substantially lower level than non-TNBC. Interestingly, a substantial inverse expression correlation was detected between circ_0044234 and miR-135b-5p as well as between miR-135b-5p and GATA3 in breast tumors. Moreover, circ_0044234 expression could be an independent prognostic biomarker in BC. No 34126989 hsa_circ_000079 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5652 No 31026505 hsa_circ_005521 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5653 No 31026505 hsa_circ_103671 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .135) were identified No 31261542 hsa_circ_005752 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .134) were identified No 31261542 hsa_circ_000263 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5654 No 31026505 hsa_circ_000970 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .133) were identified No 31261542 hsa_circ_006214 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5655 No 31026505 hsa_circ_006353 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5656 No 31026505 hsa_circ_004663 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5657 No 31026505 hsa_circ_005995 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5658 No 31026505 hsa_circ_101212 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .132) were identified No 31261542 hsa_circ_103366 CircRNA Homo sapiens Alzheimer Disease blood Expression[highly expressed] qRT-PCR//Microarray We performed qRT-PCR to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015, suggesting that these two circRNAs were expressed at a low level or not expressed at all (Fig. 3). No 31834549 hsa_circ_103936 CircRNA Homo sapiens Alzheimer Disease blood Expression[highly expressed] qRT-PCR//Microarray We performed qRT-PCR to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015, suggesting that these two circRNAs were expressed at a low level or not expressed at all (Fig. 3). No 31834549 hsa_circ_000788 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5659 No 31026505 hsa_circ_101618 CircRNA Homo sapiens Alzheimer Disease blood Expression[highly expressed] qRT-PCR//Microarray We performed qRT-PCR to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015, suggesting that these two circRNAs were expressed at a low level or not expressed at all (Fig. 3). No 31834549 hsa_circ_001326 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .131) were identified No 31261542 hsa_circ_103710 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .130) were identified No 31261542 hsa_circ_044097 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .144) were identified No 31261542 hsa_circ_006884 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5650 No 31026505 hsa_circ_006172 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6286 No 31026505 hsa_circ_101379 CircRNA Homo sapiens Carcinoma, Adenoid Cystic cell lines Expression[highly expressed] qRT-PCR qRT-PCR confirmed hsa_circRNA_092556, hsa_circRNA_101379, and hsa_circRNA_001982 up-regulation in SACC-LM. miR-181a-5p was down-regulated in SACC-LM and correlated with up-regulated hsa_circRNA_001982. No 33237453 hsa_circ_004048 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6295 No 31026505 hsa_circ_104865 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .153) were identified No 31261542 hsa_circ_023670 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .152) were identified No 31261542 hsa_circ_053294 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .151) were identified No 31261542 hsa_circ_104978 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .150) were identified No 31261542 hsa_circ_006589 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6294 No 31026505 hsa_circ_005515 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5644 No 31026505 hsa_circ_001827 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6293 No 31026505 hsa_circ_006458 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5645 No 31026505 hsa_circ_092556 CircRNA Homo sapiens Carcinoma, Adenoid Cystic cell lines Expression[highly expressed] qRT-PCR//Wound Healing Assay//Transwell Assay qRT-PCR confirmed hsa_circRNA_092556, hsa_circRNA_101379, and hsa_circRNA_001982 up-regulation in SACC-LM. miR-181a-5p was down-regulated in SACC-LM and correlated with up-regulated hsa_circRNA_001982. No 33237453 hsa_circ_000489 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .149) were identified No 31261542 hsa_circ_007292 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6292 No 31026505 hsa_circ_003459 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5646 No 31026505 circCDYL CircRNA Homo sapiens Triple Negative Breast Neoplasms breast cancer tissues and cells regulation[miR-190a-3p/TP53INP1 axis] CCK8//qRT-PCR//Colony Formation Assay//Western Blot CircCDYL were down-regulated in breast cancer tissues and cells, the expression of which positively correlated with patients' survival rate.CircCDYL promotes apoptosis and inhibits proliferation of the malignant phenotype of breast cancer through regulating miR-190a-3p/TP53INP1 axis, which suggests that circCDYL is a potential therapeutic target for breast cancer. CircCDYL were down-regulated in breast cancer tissues and cells, the expression of which positively correlated with patients' survival rate. No 32741666 hsa_circ_001895 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6291 No 31026505 hsa_circ_003776 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5647 No 31026505 hsa_circ_000934 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6290 No 31026505 hsa_circ_002874 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5648 No 31026505 hsa_circ_000387 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6289 No 31026505 hsa_circ_100517 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .148) were identified No 31261542 hsa_circ_001135 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5649 No 31026505 hsa_circ_104866 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .147) were identified No 31261542 hsa_circ_103139 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .146) were identified No 31261542 hsa_circ_087962 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .145) were identified No 31261542 hsa_circ_004123 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6288 No 31026505 hsa_circ_006489 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6287 No 31026505 hsa_circ_001609 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5603 No 31026505 hsa_circ_002967 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5602 No 31026505 hsa_circ_006249 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5601 No 31026505 hsa_circ_007301 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6312 No 31026505 hsa_circ_007225 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5554 No 31026505 CBT15_circR_5700 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 11 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_1996 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 10 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_7078 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 9 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_004544 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5555 No 31026505 hsa_circ_004584 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5556 No 31026505 hsa_circ_102100 CircRNA Homo sapiens Idiopathic Pulmonary Fibrosis plasma Expression[highly expressed] qRT-PCR Further validation of the results by polymerase chain reaction analysis indicated that Homo sapiens (hsa)_circRNA_100906, hsa_circRNA_102100 and hsa_circRNA_102348 were significantly upregulated, whereas hsa_circRNA_101225, hsa_circRNA_104780 and hsa_circRNA_101242 were downregulated in plasma samples of IPF patients compared with those in samples from healthy controls. No 30272257 hsa_circ_002745 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5557 No 31026505 CBT15_circR_5702 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 8 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_172 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 7 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_160 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 6 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_007023 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5558 No 31026505 hsa_circ_003474 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5559 No 31026505 hsa_circ_006308 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5560 No 31026505 hsa_circ_006143 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5561 No 31026505 hsa_circ_005789 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5562 No 31026505 hsa_circ_002746 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5563 No 31026505 CBT15_circR_6041 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 5 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_6841 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 4 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_001179 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5564 No 31026505 hsa_circ_005512 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5565 No 31026505 hsa_circ_005912 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5566 No 31026505 hsa_circ_000830 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5567 No 31026505 CBT15_circR_2290 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 3 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_001656 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5568 No 31026505 hsa_circ_001181 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5569 No 31026505 CBT15_circR_1646 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 2 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_2932 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 12 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_000893 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5553 No 31026505 CBT15_circR_5810 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 13 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_2289 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 22 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_1984 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 27 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_002179 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5543 No 31026505 CBT15_circR_3245 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 26 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_004603 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5544 No 31026505 CBT15_circR_3242 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 25 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_000034 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5545 No 31026505 hsa_circ_006176 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6314 No 31026505 CBT15_circR_6417 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 24 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_001035 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5546 No 31026505 hsa_circ_004626 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6313 No 31026505 CBT15_circR_136 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 23 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_005123 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5547 No 31026505 CBT15_circR_312 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 21 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_006731 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5552 No 31026505 CBT15_circR_4498 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 20 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_6001 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 19 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_000840 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5548 No 31026505 CBT15_circR_225 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 18 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_006138 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5549 No 31026505 CBT15_circR_6378 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 17 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_004485 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5550 No 31026505 hsa_circ_007122 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5551 No 31026505 CBT15_circR_6056 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 16 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_7249 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 15 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 CBT15_circR_4672 CircRNA Homo sapiens Lubrication Disorders vaginal epithelial tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Among Expression[Expression[up-expression]-expression]regulated circRNAs, there are 19 circRNAs showing no spliced reads per billion mapping, and among Expression[down-expression]regulated circRNAs, there are 37 circRNAs showing no spliced reads per billion mapping. The top deregulated circRNAs were picked out as listed in Table 14 , from which it can be concluded that the circRNA expression in LD groExpression[Expression[up-expression]-expression]s was quite dissimilar from that in NC groExpression[Expression[up-expression]-expression]s. No 31551192 hsa_circ_100906 CircRNA Homo sapiens Idiopathic Pulmonary Fibrosis plasma Expression[highly expressed] qRT-PCR Further validation of the results by polymerase chain reaction analysis indicated that Homo sapiens (hsa)_circRNA_100906, hsa_circRNA_102100 and hsa_circRNA_102348 were significantly upregulated, whereas hsa_circRNA_101225, hsa_circRNA_104780 and hsa_circRNA_101242 were downregulated in plasma samples of IPF patients compared with those in samples from healthy controls. No 30272257 hsa_circ_001180 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5570 No 31026505 hsa_circ_000982 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6311 No 31026505 hsa_circ_005311 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6305 No 31026505 hsa_circ_004914 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6310 No 31026505 hsa_circ_000010 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5584 No 31026505 hsa_circ_001247 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5585 No 31026505 hsa_circ_004301 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5586 No 31026505 hsa_circ_003265 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5587 No 31026505 hsa_circ_003920 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6308 No 31026505 hsa_circ_005963 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5588 No 31026505 hsa_circ_006097 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6307 No 31026505 hsa_circ_7474 CircRNA Homo sapiens Ovarian Neoplasms HGSOC tissues, cell lines(SKOV-3, HO 8910, and A2786) Expression[differently expression] qRT-PCR//RNA-seq Differential expression of 7 circRNAs (circRNA385, circRNA2058, circRNA3336, circRNA2606, circRNA1656, circRNA1312 and circRNA7474) in HGSOC tissue was confirmed by qRT-PCR. The expression of circRNA1662 was Expression[down-expression]-regulated in HGSOC tissues and ovarian cancer cell lines, and correlated with the FIGO stage of HGSOC. No 31019161 hsa_circ_1312 CircRNA Homo sapiens Ovarian Neoplasms HGSOC tissues, cell lines(SKOV-3, HO 8910, and A2785) Expression[differently expression] qRT-PCR//RNA-seq Differential expression of 7 circRNAs (circRNA385, circRNA2058, circRNA3336, circRNA2606, circRNA1656, circRNA1312 and circRNA7474) in HGSOC tissue was confirmed by qRT-PCR. The expression of circRNA1661 was Expression[down-expression]-regulated in HGSOC tissues and ovarian cancer cell lines, and correlated with the FIGO stage of HGSOC. No 31019161 hsa_circ_006650 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5589 No 31026505 hsa_circ_2606 CircRNA Homo sapiens Ovarian Neoplasms HGSOC tissues, cell lines(SKOV-3, HO 8910, and A2784) Expression[differently expression] qRT-PCR//RNA-seq Differential expression of 7 circRNAs (circRNA385, circRNA2058, circRNA3336, circRNA2606, circRNA1656, circRNA1312 and circRNA7474) in HGSOC tissue was confirmed by qRT-PCR. The expression of circRNA1660 was Expression[down-expression]-regulated in HGSOC tissues and ovarian cancer cell lines, and correlated with the FIGO stage of HGSOC. No 31019161 hsa_circ_003270 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5590 No 31026505 hsa_circ_3336 CircRNA Homo sapiens Ovarian Neoplasms HGSOC tissues, cell lines(SKOV-3, HO 8910, and A2783) Expression[differently expression] qRT-PCR//RNA-seq Differential expression of 7 circRNAs (circRNA385, circRNA2058, circRNA3336, circRNA2606, circRNA1656, circRNA1312 and circRNA7474) in HGSOC tissue was confirmed by qRT-PCR. The expression of circRNA1659 was Expression[down-expression]-regulated in HGSOC tissues and ovarian cancer cell lines, and correlated with the FIGO stage of HGSOC. No 31019161 hsa_circ_2058 CircRNA Homo sapiens Ovarian Neoplasms HGSOC tissues, cell lines(SKOV-3, HO 8910, and A2782) Expression[differently expression] qRT-PCR//RNA-seq Differential expression of 7 circRNAs (circRNA385, circRNA2058, circRNA3336, circRNA2606, circRNA1656, circRNA1312 and circRNA7474) in HGSOC tissue was confirmed by qRT-PCR. The expression of circRNA1658 was Expression[down-expression]-regulated in HGSOC tissues and ovarian cancer cell lines, and correlated with the FIGO stage of HGSOC. No 31019161 hsa_circ_000999 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5591 No 31026505 hsa_circ_385 CircRNA Homo sapiens Ovarian Neoplasms HGSOC tissues, cell lines(SKOV-3, HO 8910, and A2781) Expression[differently expression] qRT-PCR//RNA-seq Differential expression of 7 circRNAs (circRNA385, circRNA2058, circRNA3336, circRNA2606, circRNA1656, circRNA1312 and circRNA7474) in HGSOC tissue was confirmed by qRT-PCR. The expression of circRNA1657 was Expression[down-expression]-regulated in HGSOC tissues and ovarian cancer cell lines, and correlated with the FIGO stage of HGSOC. No 31019161 hsa_circ_006124 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5592 No 31026505 hsa_circ_1656 CircRNA Homo sapiens Ovarian Neoplasms HGSOC tissues, cell lines(SKOV-3, HO 8910, and A2780) Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Differential expression of 7 circRNAs (circRNA385, circRNA2058, circRNA3336, circRNA2606, circRNA1656, circRNA1312 and circRNA7474) in HGSOC tissue was confirmed by qRT-PCR. The expression of circRNA1656 was Expression[down-expression]-regulated in HGSOC tissues and ovarian cancer cell lines, and correlated with the FIGO stage of HGSOC. No 31019161 hsa_circ_005215 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6306 No 31026505 hsa_circ_001758 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5593 No 31026505 hsa_circ_007220 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5594 No 31026505 hsa_circ_006916 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5595 No 31026505 hsa_circ_002021 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5596 No 31026505 hsa_circ_000190 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5597 No 31026505 hsa_circ_004454 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5598 No 31026505 hsa_circ_006845 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5599 No 31026505 hsa_circ_007174 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5600 No 31026505 hsa_circ_001340 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6309 No 31026505 hsa_circ_000059 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5583 No 31026505 hsa_circ_007324 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5582 No 31026505 hsa_circ_102505 CircRNA Homo sapiens bladder carcinoma BC and adjacent non‑neoplastic bladder tissues Expression [highly expressed] qRT-PCR//Microarray The results revealed upregulation of hsa_circRNA_100086, _038632, _100876, _102241, _004646, _102505, _104600, and _005411 expression in BC tissues relative to their levels in ANNB tissues, whereas hsa_circRNA_001409, _101969, and _103801 were downregulated. No 33200221 hsa_circ_007000 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5571 No 31026505 hsa_circ_103801 CircRNA Homo sapiens bladder carcinoma BC and adjacent non‑neoplastic bladder tissues Expression [lower expressed] qRT-PCR//Microarray The results revealed upregulation of hsa_circRNA_100086, _038632, _100876, _102241, _004646, _102505, _104600, and _005411 expression in BC tissues relative to their levels in ANNB tissues, whereas hsa_circRNA_001409, _101969, and _103801 were downregulated. No 33200221 hsa_circ_101969 CircRNA Homo sapiens bladder carcinoma BC and adjacent non‑neoplastic bladder tissues Expression [lower expressed] qRT-PCR//Microarray The results revealed upregulation of hsa_circRNA_100086, _038632, _100876, _102241, _004646, _102505, _104600, and _005411 expression in BC tissues relative to their levels in ANNB tissues, whereas hsa_circRNA_001409, _101969, and _103801 were downregulated. No 33200221 hsa_circ_102348 CircRNA Homo sapiens Idiopathic Pulmonary Fibrosis plasma Expression[highly expressed] qRT-PCR Further validation of the results by polymerase chain reaction analysis indicated that Homo sapiens (hsa)_circRNA_100906, hsa_circRNA_102100 and hsa_circRNA_102348 were significantly upregulated, whereas hsa_circRNA_101225, hsa_circRNA_104780 and hsa_circRNA_101242 were downregulated in plasma samples of IPF patients compared with those in samples from healthy controls. No 30272257 hsa_circ_002820 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5572 No 31026505 hsa_circ_001409 CircRNA Homo sapiens bladder carcinoma BC and adjacent non‑neoplastic bladder tissues Expression [lower expressed] qRT-PCR//Microarray The results revealed upregulation of hsa_circRNA_100086, _038632, _100876, _102241, _004646, _102505, _104600, and _005411 expression in BC tissues relative to their levels in ANNB tissues, whereas hsa_circRNA_001409, _101969, and _103801 were downregulated. No 33200221 hsa_circ_002175 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5573 No 31026505 hsa_circ_005411 CircRNA Homo sapiens bladder carcinoma BC and adjacent non‑neoplastic bladder tissues Expression [highly expressed] qRT-PCR//Microarray The results revealed upregulation of hsa_circRNA_100086, _038632, _100876, _102241, _004646, _102505, _104600, and _005411 expression in BC tissues relative to their levels in ANNB tissues, whereas hsa_circRNA_001409, _101969, and _103801 were downregulated. No 33200221 hsa_circ_104600 CircRNA Homo sapiens bladder carcinoma BC and adjacent non‑neoplastic bladder tissues Expression [highly expressed] qRT-PCR//Microarray The results revealed upregulation of hsa_circRNA_100086, _038632, _100876, _102241, _004646, _102505, _104600, and _005411 expression in BC tissues relative to their levels in ANNB tissues, whereas hsa_circRNA_001409, _101969, and _103801 were downregulated. No 33200221 hsa_circ_002821 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5574 No 31026505 hsa_circ_002694 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5575 No 31026505 hsa_circ_000892 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5576 No 31026505 hsa_circ_000890 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5577 No 31026505 hsa_circ_103516 CircRNA Homo sapiens Inflammatory Bowel Diseases blood Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR Expression of circRNA_103516 in PBMCs was increased in CD patients [2.085 (1.195­3.510)] compared with that in UC patients [1.385 (0.925­2.599), P = 0.003], HCs [0.901 (0.724­1.376), P < 0.001], and PCs [0.901 (0.742­1.375), P < 0.001]. The expression level of circRNA_103516 was higher in PBMCs from the UC groExpression[Expression[up-expression]-expression] compared with those of the HC (P = 0.004) and PC (P = 0.025) groExpression[Expression[up-expression]-expression]s. No 31749597 hsa_circ_006070 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5578 No 31026505 hsa_circ_006074 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5579 No 31026505 hsa_circ_004930 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5580 No 31026505 hsa_circ_101225 CircRNA Homo sapiens Idiopathic Pulmonary Fibrosis plasma Expression[lower expressed] qRT-PCR Further validation of the results by polymerase chain reaction analysis indicated that Homo sapiens (hsa)_circRNA_100906, hsa_circRNA_102100 and hsa_circRNA_102348 were significantly upregulated, whereas hsa_circRNA_101225, hsa_circRNA_104780 and hsa_circRNA_101242 were downregulated in plasma samples of IPF patients compared with those in samples from healthy controls. No 30272257 hsa_circ_004646 CircRNA Homo sapiens bladder carcinoma BC and adjacent non‑neoplastic bladder tissues Expression [highly expressed] qRT-PCR//Microarray The results revealed upregulation of hsa_circRNA_100086, _038632, _100876, _102241, _004646, _102505, _104600, and _005411 expression in BC tissues relative to their levels in ANNB tissues, whereas hsa_circRNA_001409, _101969, and _103801 were downregulated. No 33200221 hsa_circ_102241 CircRNA Homo sapiens bladder carcinoma BC and adjacent non‑neoplastic bladder tissues Expression [highly expressed] qRT-PCR//Microarray The results revealed upregulation of hsa_circRNA_100086, _038632, _100876, _102241, _004646, _102505, _104600, and _005411 expression in BC tissues relative to their levels in ANNB tissues, whereas hsa_circRNA_001409, _101969, and _103801 were downregulated. No 33200221 hsa_circ_104780 CircRNA Homo sapiens Idiopathic Pulmonary Fibrosis plasma Expression[lower expressed] qRT-PCR Further validation of the results by polymerase chain reaction analysis indicated that Homo sapiens (hsa)_circRNA_100906, hsa_circRNA_102100 and hsa_circRNA_102348 were significantly upregulated, whereas hsa_circRNA_101225, hsa_circRNA_104780 and hsa_circRNA_101242 were downregulated in plasma samples of IPF patients compared with those in samples from healthy controls. No 30272257 hsa_circ_038632 CircRNA Homo sapiens bladder carcinoma BC and adjacent non‑neoplastic bladder tissues Expression [highly expressed] qRT-PCR//Microarray The results revealed upregulation of hsa_circRNA_100086, _038632, _100876, _102241, _004646, _102505, _104600, and _005411 expression in BC tissues relative to their levels in ANNB tissues, whereas hsa_circRNA_001409, _101969, and _103801 were downregulated. No 33200221 hsa_circ_101242 CircRNA Homo sapiens Idiopathic Pulmonary Fibrosis plasma Expression[lower expressed] qRT-PCR Further validation of the results by polymerase chain reaction analysis indicated that Homo sapiens (hsa)_circRNA_100906, hsa_circRNA_102100 and hsa_circRNA_102348 were significantly upregulated, whereas hsa_circRNA_101225, hsa_circRNA_104780 and hsa_circRNA_101242 were downregulated in plasma samples of IPF patients compared with those in samples from healthy controls. No 30272257 hsa_circ_100086 CircRNA Homo sapiens bladder carcinoma BC and adjacent non‑neoplastic bladder tissues Expression [highly expressed] qRT-PCR//Microarray The results revealed upregulation of hsa_circRNA_100086, _038632, _100876, _102241, _004646, _102505, _104600, and _005411 expression in BC tissues relative to their levels in ANNB tissues, whereas hsa_circRNA_001409, _101969, and _103801 were downregulated. No 33200221 hsa_circ_0001924 CircRNA Homo sapiens Idiopathic Pulmonary Fibrosis blood Expression[lower expressed] qRT-PCR We confirmed the downregulation of FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR) lncRNA, hsa_circ_0001924 circularRNA, utrophin (UTRN) and Y-box binding protein 3 (YBX3) mRNAs. No 33233868 hsa_circ_004469 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5581 No 31026505 hsa-circ_9102-5 CircRNA Homo sapiens Essential Hypertension blood Expression[highly expressed] qRT-PCR Hsa-circRNA9102-5 (11.7 ± 1.06 vs 12.13 ± 1.11, P = .007) was up-regulated in the patients group which was diagnosed with EH, as compared to the HC group, and was involved in the regulation of EH by sponging hsa-miR-150-5p. No 32445294 hsa_circ_003082 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5442 No 31026505 hsa_circ_0036881 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0016624 CircRNA Homo sapiens Osteoporosis, Postmenopausal postmenopausal osteoporosis tissue Expression[lower expressed] qRT-PCR//RNA-seq//Western Blot There were 387 circRNAs were differentially expressed in osteoporosis (|fold change| > 2 and P-value < 0.01). circRNA_0016624 and BMP2 were down-regulated in osteoporosis. No 31235259 hsa_circ_006624 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6381 No 31026505 hsa_circ_005267 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6380 No 31026505 hsa_circ_000554 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6379 No 31026505 hsa_circ_101566 CircRNA Homo sapiens capillary hemangioma blood samples Expression [lower expressed] qRT-PCR//Microarray From the circRNA expression profiles in the plasma of patients with IHs, 128 differentially expressed circRNAs were identified, of which 72 were upregulated and 56 were downregulated. Based on known data of microarray analysis, 10 circRNAs we selected for RT-qPCR validation, including 6 upregulated and 4 downregulated circRNAs. No 33968165 hsa_circ_103573 CircRNA Homo sapiens capillary hemangioma blood samples Expression [lower expressed] qRT-PCR//Microarray From the circRNA expression profiles in the plasma of patients with IHs, 128 differentially expressed circRNAs were identified, of which 72 were upregulated and 56 were downregulated. Based on known data of microarray analysis, 10 circRNAs we selected for RT-qPCR validation, including 6 upregulated and 4 downregulated circRNAs. No 33968165 hsa_circ_103546 CircRNA Homo sapiens capillary hemangioma blood samples Expression [lower expressed] qRT-PCR//Microarray From the circRNA expression profiles in the plasma of patients with IHs, 128 differentially expressed circRNAs were identified, of which 72 were upregulated and 56 were downregulated. Based on known data of microarray analysis, 10 circRNAs we selected for RT-qPCR validation, including 6 upregulated and 4 downregulated circRNAs. No 33968165 hsa_circ_102101 CircRNA Homo sapiens capillary hemangioma blood samples Expression [lower expressed] qRT-PCR//Microarray From the circRNA expression profiles in the plasma of patients with IHs, 128 differentially expressed circRNAs were identified, of which 72 were upregulated and 56 were downregulated. Based on known data of microarray analysis, 10 circRNAs we selected for RT-qPCR validation, including 6 upregulated and 4 downregulated circRNAs. No 33968165 hsa_circ_023016 CircRNA Homo sapiens capillary hemangioma blood samples Expression [highly expressed] qRT-PCR//Microarray From the circRNA expression profiles in the plasma of patients with IHs, 128 differentially expressed circRNAs were identified, of which 72 were upregulated and 56 were downregulated. Based on known data of microarray analysis, 10 circRNAs we selected for RT-qPCR validation, including 6 upregulated and 4 downregulated circRNAs. No 33968165 hsa_circ_062683 CircRNA Homo sapiens capillary hemangioma blood samples Expression [highly expressed] qRT-PCR//Microarray From the circRNA expression profiles in the plasma of patients with IHs, 128 differentially expressed circRNAs were identified, of which 72 were upregulated and 56 were downregulated. Based on known data of microarray analysis, 10 circRNAs we selected for RT-qPCR validation, including 6 upregulated and 4 downregulated circRNAs. No 33968165 hsa_circ_104310 CircRNA Homo sapiens capillary hemangioma blood samples Expression [highly expressed] qRT-PCR//Microarray From the circRNA expression profiles in the plasma of patients with IHs, 128 differentially expressed circRNAs were identified, of which 72 were upregulated and 56 were downregulated. Based on known data of microarray analysis, 10 circRNAs we selected for RT-qPCR validation, including 6 upregulated and 4 downregulated circRNAs. No 33968165 hsa_circ_103361 CircRNA Homo sapiens capillary hemangioma blood samples Expression [highly expressed] qRT-PCR//Microarray From the circRNA expression profiles in the plasma of patients with IHs, 128 differentially expressed circRNAs were identified, of which 72 were upregulated and 56 were downregulated. Based on known data of microarray analysis, 10 circRNAs we selected for RT-qPCR validation, including 6 upregulated and 4 downregulated circRNAs. No 33968165 hsa_circ_103372 CircRNA Homo sapiens capillary hemangioma blood samples Expression [highly expressed] qRT-PCR//Microarray From the circRNA expression profiles in the plasma of patients with IHs, 128 differentially expressed circRNAs were identified, of which 72 were upregulated and 56 were downregulated. Based on known data of microarray analysis, 10 circRNAs we selected for RT-qPCR validation, including 6 upregulated and 4 downregulated circRNAs. No 33968165 hsa_circ_001490 CircRNA Homo sapiens capillary hemangioma blood samples Expression [highly expressed] qRT-PCR//Microarray From the circRNA expression profiles in the plasma of patients with IHs, 128 differentially expressed circRNAs were identified, of which 72 were upregulated and 56 were downregulated. Based on known data of microarray analysis, 10 circRNAs we selected for RT-qPCR validation, including 6 upregulated and 4 downregulated circRNAs. No 33968165 circCHST12 CircRNA Homo sapiens Cerebral Hemorrhage ICH patients Regulation qRT-PCR//Bioinformatics Analysis The combination of the novel circERBB2 and circCHST12 in ICH patients and healthy controls showed an area under the curve of 0.917 (95% CI: 0.869-0.965), with a sensitivity of 87.5% and a specificity of 82%. No 36523430 circERBB2 CircRNA Homo sapiens Cerebral Hemorrhage ICH patients Regulation qRT-PCR//Bioinformatics Analysis The combination of the novel circERBB2 and circCHST12 in ICH patients and healthy controls showed an area under the curve of 0.917 (95% CI: 0.869-0.965), with a sensitivity of 87.5% and a specificity of 82%. No 36523430 hsa_circ_002987 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5227 No 31026505 hsa_circ_0021739 CircRNA Homo sapiens Osteoporosis, Postmenopausal Fifty-three postmenopausal women Regulation Transfection//qPCR RESULTS Among 4 circRNAs previously identified by RNA-sequencing analysis as differentially expressed in patients with postmenopausal osteoporosis, only hsa_circ_0021739 showed a significant difference in expression between the groups and was downregulated in patients with postmenopausal osteoporosis. No 33875631 hsa_circ_001090 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5228 No 31026505 hsa_circ_003887 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5229 No 31026505 hsa_circ_0006848 CircRNA Homo sapiens microinvasive gastric cancer EGC tissues Expression[lower expressed] qRT-PCR The hsa_circ_0006848 expression was significantly downregulated in EGC tissues (vs. nontumorous tissues, n = 30, p = 0.0073) and plasma samples from EGC patients (vs. paired healthy volunteers, n = 30, p = 0.0089). In addition, the hsa_circ_0006848 plasma level in postoperative patients was significantly higher than that of preoperative patients (n = 30, p = 0.047). Furthermore, the decreased hsa_circ_0006848 expression in plasma was negatively correlated with poor differentiation (p = 0.037) and tumor size (p = 0.046). No 31565098 hsa_circ_006556 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5230 No 31026505 hsa_circ_002700 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6378 No 31026505 hsa_circ_0102533 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissues and whole blood from NSCLC patients Expression[highly expressed] CCK8//qRT-PCR Compared with the control group, hsa_circ_0102533 expression was significantly increased in tumor tissues and whole blood from NSCLC patients. No 31949836 hsa_circ_000556 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6377 No 31026505 hsa_circ_007184 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6376 No 31026505 hsa_circ_103124 CircRNA Homo sapiens Crohn Disease blood Expression[highly expressed] qRT-PCR//Microarray 7 circRNAs (092520, 102610, 004662, and 103124) were significantly up-regulated validated by RT-PCR and qPCR between CD and HCs. ROC curve analysis suggested important values of circRNAs (092520, 102610, 004662, and 103124) in CD diagnosis, with area under the curve (AUC) as 0.66, 0.78, 0.85, and 0.74, respectively. Then, we further identified that the relative expression levels of circRNA_004662 was upregulated significantly in CD patients compared with UC patients. No 31261517 hsa_circ_006806 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6382 No 31026505 hsa_circ_0043314 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_000950 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5441 No 31026505 hsa_circ_0062614 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_001336 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5213 No 31026505 hsa_circ_000171 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5214 No 31026505 hsa_circ_0015911 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_001877 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5215 No 31026505 hsa_circ_002474 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5216 No 31026505 hsa_circ_0075671 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_003240 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6385 No 31026505 hsa_circ_0043705 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_000922 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5217 No 31026505 hsa_circ_001129 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6384 No 31026505 hsa_circ_0001218 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 circMTO1 CircRNA Homo sapiens Gallbladder Neoplasms GBC tissues,blood Expression[highly expressed] qRT-PCR Circ-MTO1 expression was significantly upregulated in tumor tissues and plasma in GBC patients. In addition, circ-MTO1 expression was associated with clinical-pathological characteristics in GBC. High circ-MTO1 expression served as an independent prognostic factor for poor OS and PFS in GBC patients. Moreover, upregulated plasma circ-MTO1 level was significantly associated with tumor development. No 32894542 hsa_circ_0066860 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0055707 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0064299 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_002976 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5218 No 31026505 hsa_circ_0003470 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_005776 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5219 No 31026505 hsa_circ_0004890 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_000728 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5220 No 31026505 hsa_circ_006643 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5221 No 31026505 hsa_circ_002365 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5222 No 31026505 hsa_circ_002841 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5223 No 31026505 hsa_circ_001624 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5224 No 31026505 hsa_circ_002275 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5225 No 31026505 hsa_circ_000979 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6383 No 31026505 hsa_circ_000688 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5226 No 31026505 hsa_circ_102610 CircRNA Homo sapiens Crohn Disease blood Expression[highly expressed] qRT-PCR//Microarray 6 circRNAs (092520, 102610, 004662, and 103124) were significantly up-regulated validated by RT-PCR and qPCR between CD and HCs. ROC curve analysis suggested important values of circRNAs (092520, 102610, 004662, and 103124) in CD diagnosis, with area under the curve (AUC) as 0.66, 0.78, 0.85, and 0.74, respectively. Then, we further identified that the relative expression levels of circRNA_004662 was upregulated significantly in CD patients compared with UC patients. No 31261517 hsa_circ_92520 CircRNA Homo sapiens Crohn Disease blood Expression[highly expressed] qRT-PCR//Microarray 5 circRNAs (092520, 102610, 004662, and 103124) were significantly up-regulated validated by RT-PCR and qPCR between CD and HCs. ROC curve analysis suggested important values of circRNAs (092520, 102610, 004662, and 103124) in CD diagnosis, with area under the curve (AUC) as 0.66, 0.78, 0.85, and 0.74, respectively. Then, we further identified that the relative expression levels of circRNA_004662 was upregulated significantly in CD patients compared with UC patients. No 31261517 hsa_circ_002992 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5231 No 31026505 hsa_circ_005853 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5232 No 31026505 hsa_circ_000766 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6373 No 31026505 hsa_circ_007170 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5253 No 31026505 hsa_circ_006832 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5254 No 31026505 hsa_circ_000593 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5255 No 31026505 hsa_circ_002747 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5256 No 31026505 hsa_circ_005580 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5257 No 31026505 hsa_circ_000887 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6372 No 31026505 hsa_circ_007241 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5258 No 31026505 hsa_circ_000403 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5259 No 31026505 hsa_circ_002732 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5260 No 31026505 hsa_circ_000716 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5261 No 31026505 hsa_circ_003383 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5262 No 31026505 hsa_circ_000452 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5263 No 31026505 hsa_circ_004618 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5264 No 31026505 hsa_circ_000820 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5265 No 31026505 hsa_circ_001824 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6371 No 31026505 hsa_circ_000068 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6370 No 31026505 hsa_circ_002569 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6369 No 31026505 hsa_circ_004520 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5266 No 31026505 hsa_circ_005667 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6368 No 31026505 hsa_circ_004063 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6367 No 31026505 hsa_circ_005237 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6366 No 31026505 hsa_circ_005643 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6365 No 31026505 hsa_circ_006435 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6364 No 31026505 circTGFBR3 CircRNA Homo sapiens Neuroblastoma Five paired neuroblastoma tumor and adjacent normal fetal adrenal medulla samples Expression(lower expressed) qRT-PCR//circRNA-seq//migration assay//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis A total of 4704 differentially expressed circRNAs were found, including 2462 up-regulated and 2242 down-regulated circRNAs. According to our previous studies, the predicted target circRNAs of miR-21 involved in tumorigenic signaling pathways were selected, including circRNA-TBC1D4, circRNA-NAALAD2 and circRNA-TGFBR3. These circRNAs were associated with clinical features, and the circRNA expression was significantly lower (P < 0.05) in the NB tissues than in normal adrenal tissues. No 34093041 circNAALAD2 CircRNA Homo sapiens Neuroblastoma Five paired neuroblastoma tumor and adjacent normal fetal adrenal medulla samples Expression(lower expressed) qRT-PCR//circRNA-seq//migration assay//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis A total of 4704 differentially expressed circRNAs were found, including 2462 up-regulated and 2242 down-regulated circRNAs. According to our previous studies, the predicted target circRNAs of miR-21 involved in tumorigenic signaling pathways were selected, including circRNA-TBC1D4, circRNA-NAALAD2 and circRNA-TGFBR3. These circRNAs were associated with clinical features, and the circRNA expression was significantly lower (P < 0.05) in the NB tissues than in normal adrenal tissues. No 34093041 circCUX1 CircRNA Homo sapiens Neuroblastoma cell lines Regulation[circ-CUX1/EWSR1/MAZ axis] RNA Pull-Down//Northern Blot//Western Blot//Co-IP//qRT-PCR//FISH//RIP//Luciferase Report Assay//RNA-seq//ChIP "Notably, circ‐CUX1 levels were higher in tissues of NB, colon cancer, and prostate cancer, than normal fetal adrenal medulla or adjacent normal tissues (Fig 2G). In addition, circ‐CUX1 levels were positively correlated with those of CUX1 in tissues of NB (R = 0.590, P < 0.0001), colon cancer (R = 0.868, P < 0.0001), or prostate cancer (R = 0.619, P = 0.0023; Fig 2G). In 54 primary NB tumors, higher circ‐CUX1 levels were observed in cases with poor stroma (P = 0.0083) or advanced INSS stages (P = 0.0017), without association with MYCN amplification (P = 0.1532; Fig EV1E). Patients with high circ‐CUX1 expression had lower survival probability (Fig EV1F). These results indicated that circ‐CUX1 was up‐regulated in NB tissues and cell lines.These results indicate circ-CUX1/EWSR1/MAZ axis as a therapeutic target for aerobic glycolysis and NB progression. " No 31709724 hsa_circ_002392 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5252 No 31026505 hsa_circ_006008 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5251 No 31026505 hsa_circ_002774 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5250 No 31026505 hsa_circ_004203 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5240 No 31026505 hsa_circ_004662 CircRNA Homo sapiens Crohn Disease blood Expression[highly expressed] qRT-PCR//Microarray 4 circRNAs (092520, 102610, 004662, and 103124) were significantly up-regulated validated by RT-PCR and qPCR between CD and HCs. ROC curve analysis suggested important values of circRNAs (092520, 102610, 004662, and 103124) in CD diagnosis, with area under the curve (AUC) as 0.66, 0.78, 0.85, and 0.74, respectively. Then, we further identified that the relative expression levels of circRNA_004662 was upregulated significantly in CD patients compared with UC patients. No 31261517 hsa_circ_006050 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6375 No 31026505 hsa_circ_003235 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6374 No 31026505 hsa_circ_002442 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5233 No 31026505 hsa_circ_001756 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5234 No 31026505 hsa_circ_000327 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5235 No 31026505 hsa_circ_005348 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5236 No 31026505 hsa_circ_005589 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5237 No 31026505 hsa_circ_004412 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5238 No 31026505 hsa_circ_004202 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5239 No 31026505 circMTO1 CircRNA Homo sapiens Polycystic Ovary Syndrome human granulosa-like tumor cell Interaction(miR-320b/MCL1 axis) RNA Pull-Down//Western Blot//Transfection//FISH//RIP//Luciferase Report Assay//Cell Apoptosis Assay We found that circMTO1 knockdown promoted human granulosa-like tumor cell proliferation and inhibited its apoptosis rate. Our results revealed the effect of the novel circMTO1/miR-320b/MCL1 axis in human granulosa-like tumor cells. No 34413875 hsa_circ_0097636 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray After qRT-PCR validation, the expression levels of hsa_circ_0043533 (p < 0.05) and hsa_circ_0043532 (p < 0.01) were significantly higher in the PCOS group, while the expression level of hsa_circ_0097636 (p < 0.01) was prominently lower versus the non-PCOS group. No 30941555 hsa_circ_007295 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5241 No 31026505 hsa_circ_0001438 CircRNA Homo sapiens severe pre-eclampsia placental tissues Expression[highly expressed] qPCR//RNA-seq Among these circRNAs, hsa_circ_0001438, hsa_circ_0001326, and hsa_circ_32340 were upregulated in the sPE patients and the circRNA-miRNA-mRNA interaction network generated with these three circRNAs revealed a broad regulatory network that might be involved in the pathogenesis of sPE. No 31759525 hsa_circ_005270 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5242 No 31026505 hsa_circ_002744 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5243 No 31026505 hsa_circ_001397 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5244 No 31026505 hsa_circ_001654 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5245 No 31026505 hsa_circ_007090 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5246 No 31026505 hsa_circ_0043532 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray After qRT-PCR validation, the expression levels of hsa_circ_0043533 (p < 0.05) and hsa_circ_0043532 (p < 0.01) were significantly higher in the PCOS group, while the expression level of hsa_circ_0097636 (p < 0.01) was prominently lower versus the non-PCOS group. No 30941555 hsa_circ_006595 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5247 No 31026505 hsa_circ_0043533 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray After qRT-PCR validation, the expression levels of hsa_circ_0043533 (p < 0.05) and hsa_circ_0043532 (p < 0.01) were significantly higher in the PCOS group, while the expression level of hsa_circ_0097636 (p < 0.01) was prominently lower versus the non-PCOS group. No 30941555 hsa_circ_005522 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5248 No 31026505 hsa_circ_32340 CircRNA Homo sapiens severe pre-eclampsia placental tissues Expression[highly expressed] qPCR//RNA-seq Among these circRNAs, hsa_circ_0001438, hsa_circ_0001326, and hsa_circ_32340 were upregulated in the sPE patients and the circRNA-miRNA-mRNA interaction network generated with these three circRNAs revealed a broad regulatory network that might be involved in the pathogenesis of sPE. No 31759525 hsa_circ_002762 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5249 No 31026505 hsa_circ_0001326 CircRNA Homo sapiens severe pre-eclampsia placental tissues Expression[highly expressed] qPCR//RNA-seq Among these circRNAs, hsa_circ_0001438, hsa_circ_0001326, and hsa_circ_32340 were upregulated in the sPE patients and the circRNA-miRNA-mRNA interaction network generated with these three circRNAs revealed a broad regulatory network that might be involved in the pathogenesis of sPE. No 31759525 hsa_circ_002867 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5212 No 31026505 hsa_circ_001055 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5211 No 31026505 hsa_circ_0044052 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0050612 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_002889 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5166 No 31026505 hsa_circ_006493 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5167 No 31026505 hsa_circ_006803 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5168 No 31026505 hsa_circ_006291 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5169 No 31026505 hsa_circ_007156 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6400 No 31026505 hsa_circ_003617 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5170 No 31026505 hsa_circ_002374 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5171 No 31026505 hsa_circ_004527 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6399 No 31026505 hsa_circ_003738 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6398 No 31026505 hsa_circ_004601 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5172 No 31026505 hsa_circ_003748 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6397 No 31026505 hsa_circ_003645 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6396 No 31026505 hsa_circ_007018 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6395 No 31026505 circSETDB1 CircRNA Homo sapiens Ovarian Neoplasms SOC tissues Expression[highly expressed] qRT-PCR Serum circSETDB1 expression is upregulated in SOC patients. Higher levels of circSETDB1 are positively associated with advanced clinical stage, lymph node metastasis of SOC patients. No 31686850 circPTPRA CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Non-small cell lung carcinomas tissues Interaction[sponging miR-96-5p] Northern Blot//Western Blot//qPCR//FISH//RIP//Luciferase Report Assay//Microarray//Transwell Assay circPTPRA was significantly downregulated in NSCLC tumors relative to matched healthy lung tissue.circPTPRA suppressed EMT in NSCLC cell lines and reduced metastasis in the murine xenograft model by sequestering miR-96-5p and upregulating RASSF8. Correlation analyses in patient-derived NSCLC tumor specimens supported the involvement of the circPTPRA/miR-96-5p/RASSF8/E-cadherin axis dysregulation in NSCLC tumor progression Lower circPTPRA levels correlated with metastasis and inferior survival outcomes in NSCLC patients. No 31160270 hsa_circ_0071186 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0068500 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0039213 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_005692 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6394 No 31026505 hsa_circ_001353 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5173 No 31026505 hsa_circ_001077 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6393 No 31026505 hsa_circ_007020 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6392 No 31026505 hsa_circ_0006751 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_003829 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5174 No 31026505 hsa_circ_0054970 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0055065 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0070585 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_004073 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5165 No 31026505 hsa_circ_005606 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6401 No 31026505 hsa_circ_000305 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6402 No 31026505 hsa_circ_007214 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6408 No 31026505 hsa_circ_006571 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5156 No 31026505 circAF4 CircRNA Homo sapiens Leukemia bone marrow Interaction[miR-128-3p] CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay We discovered a circRNA, named circAF4, originating from the AF4 gene, a partner of the MLL fusion gene in MLL-AF4 leukemia. We showed that circAF4 plays an oncogenic role in MLL-AF4 leukemia and promotes leukemogenesis in vitro and in vivo. More importantly, knockdown of circAF4 increases the leukemic cell apoptosis rate in MLL-AF4 leukemia cells, while no effect was observed in leukemia cells that do not carry the MLL-AF4 translocation. Mechanically, circAF4 can act as a miR-128-3p sponge, thereby releasing its inhibition on MLL-AF4 expression. No 31623653 hsa_circ_003550 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5157 No 31026505 hsa_circ_003839 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6414 No 31026505 hsa_circ_006835 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6413 No 31026505 hsa_circ_006181 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6412 No 31026505 hsa_circ_007041 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6411 No 31026505 hsa_circ_001690 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5158 No 31026505 hsa_circ_004409 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6410 No 31026505 hsa_circ_003540 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6409 No 31026505 hsa_circ_003301 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5159 No 31026505 hsa_circ_005252 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5160 No 31026505 hsa_circ_002205 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5161 No 31026505 hsa_circ_003114 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6403 No 31026505 hsa_circ_003007 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6407 No 31026505 hsa_circ_001275 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6406 No 31026505 hsa_circ_005736 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5162 No 31026505 hsa_circ_101093 CircRNA Homo sapiens Adenocarcinoma of Lung exosome, cell lines Interaction(FABP3) qPCR//IF//Luciferase Report Assay//IHC//ChIP A potential explanation is that exosomal circRNA_101093 (cir93) maintained an elevation in intracellular cir93 in LUAD to modulate AA, a poly-unsaturated fatty acid critical for ferroptosis-associated increased peroxidation in the plasma membrane. Mechanistically, cir93 interacted with and increased fatty acid-binding protein 3 (FABP3), which transported AA and facilitated its reaction with taurine. Thus, global AA was reduced, whereas N-arachidonoyl taurine (NAT, the product of AA and taurine) was induced. No 35184419 hsa_circ_0132266 CircRNA Homo sapiens Leukemia, Lymphocytic, Chronic, B-Cell blood Regulation[miR-337-3p/PML axis] Western Blot//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay Here, we observed hsa_circ_0132266 (circ_0132266), a circRNA significantly decreased in the peripheral blood mononuclear cells (PBMCs) of CLL patients compared with healthy donors, could act as an endogenous sponge of hsa-miR-337-3p (miR-337-3p) and regulate its activity, which resulted in a downstream change of target-gene PML and a consequent influence on cell viability. No 31152142 hsa_circ_0001492 CircRNA Homo sapiens Adenocarcinoma of Lung serum and serum exosomal Expression(highly expressed) qRT-PCR Expression of serum and serum exosomal hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 were significantly higher in LUAD patients than in healthy donors, and significantly lower after surgery. These three serum exosomal circRNAs were also associated with a higher cancer stage. No 35747792 hsa_circ_0001439 CircRNA Homo sapiens Adenocarcinoma of Lung serum and serum exosomal Expression(highly expressed) qRT-PCR Expression of serum and serum exosomal hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 were significantly higher in LUAD patients than in healthy donors, and significantly lower after surgery. These three serum exosomal circRNAs were also associated with a higher cancer stage. No 35747792 hsa_circ_003664 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6405 No 31026505 hsa_circ_006784 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6404 No 31026505 hsa_circ_0000896 CircRNA Homo sapiens Adenocarcinoma of Lung serum and serum exosomal Expression(highly expressed) qRT-PCR Expression of serum and serum exosomal hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 were significantly higher in LUAD patients than in healthy donors, and significantly lower after surgery. These three serum exosomal circRNAs were also associated with a higher cancer stage. No 35747792 hsa_circ_002008 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5163 No 31026505 hsa_circ_005176 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5164 No 31026505 hsa_circ_0003295 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0003775 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0002941 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0015168 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_005436 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6387 No 31026505 hsa_circ_007183 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5193 No 31026505 hsa_circ_0083952 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_004245 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5194 No 31026505 hsa_circ_004780 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5195 No 31026505 hsa_circ_0070240 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_003399 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5196 No 31026505 hsa_circ_005422 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5197 No 31026505 hsa_circ_006189 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5198 No 31026505 hsa_circ_005106 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5199 No 31026505 hsa_circ_003728 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5200 No 31026505 hsa_circ_001270 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5201 No 31026505 hsa_circ_004165 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5202 No 31026505 hsa_circ_007186 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5203 No 31026505 hsa_circ_002997 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5204 No 31026505 hsa_circ_005562 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5205 No 31026505 hsa_circ_005523 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5206 No 31026505 hsa_circ_002257 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5207 No 31026505 hsa_circ_0037369 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_006123 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5208 No 31026505 hsa_circ_006433 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6386 No 31026505 hsa_circ_0086476 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0008324 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0059623 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_003912 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5209 No 31026505 hsa_circ_0013968 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[highly expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_002998 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5210 No 31026505 hsa_circ_004374 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5192 No 31026505 hsa_circ_002721 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5191 No 31026505 hsa_circ_000370 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5190 No 31026505 hsa_circ_001367 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5181 No 31026505 hsa_circ_0029883 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0012382 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_005181 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6391 No 31026505 hsa_circ_0002425 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_003563 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5175 No 31026505 hsa_circ_000923 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5176 No 31026505 hsa_circ_0087613 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_002521 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6390 No 31026505 hsa_circ_006314 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5177 No 31026505 hsa_circ_007058 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5178 No 31026505 hsa_circ_005537 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5179 No 31026505 hsa_circ_003491 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5180 No 31026505 hsa_circ_006219 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6389 No 31026505 hsa_circ_006824 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5189 No 31026505 hsa_circ_0042499 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_002208 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5182 No 31026505 hsa_circ_003060 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5183 No 31026505 hsa_circ_000011 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5184 No 31026505 hsa_circ_001091 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5185 No 31026505 hsa_circ_006452 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5186 No 31026505 hsa_circ_001653 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5187 No 31026505 hsa_circ_002724 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5188 No 31026505 hsa_circ_002387 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6388 No 31026505 hsa_circ_0082709 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0064680 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0003915 CircRNA Homo sapiens Polycystic Ovary Syndrome PCOS tissues Expression[lower expressed] qRT-PCR//Microarray The identification of different circRNAs expression profiles between the two groups—the cumulus cells from PCOS patients and those from the control group—was evaluated by unsupervised hierarchical clustering analysis, which indicated that the expression patterns of circRNAs in 10 PCOS patients were statistically significantly different from those of the 10 patients in the control group (Fig. 1A). The unsupervised hierarchical clustering generated a tree showing a clear distinction of samples between the two groups. The volcano plots also showed the variation of circRNAs expression between both groups (see Fig. 1B). The names of the top 20 up- and 20 down- differentially expressed circRNAs, the fold change, and the P value are shown in Table 1. No 30979425 hsa_circ_0017068 CircRNA Homo sapiens severe pre-eclampsia Placental sample Expression[lower expressed] qRT-PCR//RIP//Western Blot We selected 7 of the top 10 distinctly Expression[up-expression]- or downregulated circRNAs for further validation by qRT-PCR. One-generation sequencing of qRT-PCR products was conducted to detect the junction reads of selected circRNAs. Among them, the qRT-PCR results of 6 DE-circRNAs (hsa_circ_0002888, hsa_circ_0007445, hsa_circ_0007611, hsa_circ_0011460, hsa_circ_0012737, hsa_circ_0017068) were consistent with the RNA-Seq data (Fig. 2), while one circRNA-hsa_circ_0017068 presented the opposite expression trend between the RNA-Seq data and qRT-PCR results. No 31487644 hsa_circ_0012737 CircRNA Homo sapiens severe pre-eclampsia Placental sample Expression[lower expressed] qRT-PCR//RIP//Western Blot We selected 7 of the top 10 distinctly Expression[up-expression]- or downregulated circRNAs for further validation by qRT-PCR. One-generation sequencing of qRT-PCR products was conducted to detect the junction reads of selected circRNAs. Among them, the qRT-PCR results of 6 DE-circRNAs (hsa_circ_0002888, hsa_circ_0007445, hsa_circ_0007611, hsa_circ_0011460, hsa_circ_0012737, hsa_circ_0017068) were consistent with the RNA-Seq data (Fig. 2), while one circRNA-hsa_circ_0017068 presented the opposite expression trend between the RNA-Seq data and qRT-PCR results. No 31487644 hsa_circ_0007611 CircRNA Homo sapiens severe pre-eclampsia Placental sample Expression[highly expressed] qRT-PCR//RIP//Western Blot We selected 7 of the top 10 distinctly Expression[up-expression]- or downregulated circRNAs for further validation by qRT-PCR. One-generation sequencing of qRT-PCR products was conducted to detect the junction reads of selected circRNAs. Among them, the qRT-PCR results of 6 DE-circRNAs (hsa_circ_0002888, hsa_circ_0007445, hsa_circ_0007611, hsa_circ_0011460, hsa_circ_0012737, hsa_circ_0017068) were consistent with the RNA-Seq data (Fig. 2), while one circRNA-hsa_circ_0017068 presented the opposite expression trend between the RNA-Seq data and qRT-PCR results. No 31487644 hsa_circ_0001036 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_002061 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6358 No 31026505 hsa_circ_0072083 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Expression[highly expressed] qRT-PCR The level of circ_0072083 was higher in NSCLC tissues and cells relative to that in adjacent non-tumor tissues and normal lung cells. No 32190002 hsa_circ_000780 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5391 No 31026505 hsa_circ_002001 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5392 No 31026505 hsa_circ_004364 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5393 No 31026505 hsa_circ_003795 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5394 No 31026505 hsa_circ_007036 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5395 No 31026505 hsa_circ_000653 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5396 No 31026505 hsa_circ_005330 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5397 No 31026505 hsa_circ_001738 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5398 No 31026505 hsa_circ_001499 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5399 No 31026505 hsa_circ_004366 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5400 No 31026505 hsa_circ_000410 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5401 No 31026505 hsa_circ_005244 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5402 No 31026505 hsa_circ_006139 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5403 No 31026505 hsa_circ_001501 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5404 No 31026505 hsa_circ_0036599 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_006119 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5405 No 31026505 hsa_circ_000514 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5406 No 31026505 hsa_circ_003215 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5407 No 31026505 hsa_circ_003307 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5408 No 31026505 hsa_circ_005086 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6357 No 31026505 hsa_circ_006572 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5409 No 31026505 hsa_circ_004289 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5410 No 31026505 hsa_circ_005442 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5411 No 31026505 hsa_circ_0014923 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_002412 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5412 No 31026505 hsa_circ_0004203 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_0000158 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_0021569 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_000798 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5384 No 31026505 hsa_circ_001652 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5376 No 31026505 hsa_circ_003739 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6361 No 31026505 hsa_circ_006177 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6360 No 31026505 hsa_circ_001888 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5377 No 31026505 hsa_circ_003386 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5378 No 31026505 hsa_circ_0085131 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor specimens Expression[highly expressed] qRT-PCR In the present study, NSCLC tumor specimens exhibited a higher hsa_circ_0085131 level in comparison to para-tumor samples. And the higher level of hsa_circ_0085131 was associated with recurrence and poorer survival of NSCLC. No 32449799 hsa_circ_005682 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5379 No 31026505 hsa_circ_006774 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6359 No 31026505 hsa_circ_006399 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5380 No 31026505 hsa_circ_004035 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5381 No 31026505 hsa_circ_000161 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5382 No 31026505 hsa_circ_001352 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5383 No 31026505 hsa_circ_0009128 CircRNA Homo sapiens Adenocarcinoma of Lung LAC tissues Expression[Expression[highly expressed]-expression] qRT-PCR//Western Blot Two-hundred-eighty-five dysregulated circular transcripts were found in LAC tissues, among which 102 and 183 were either Expression[up-expression] or down regulated, respectively. No 30787976 hsa_circ_002748 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5390 No 31026505 hsa_circ_001128 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5385 No 31026505 hsa_circ_0006276 CircRNA Homo sapiens Adenocarcinoma of Lung LAC tissues Expression[Expression[highly expressed]-expression] qRT-PCR//Western Blot Two-hundred-eighty-five dysregulated circular transcripts were found in LAC tissues, among which 102 and 183 were either Expression[up-expression] or down regulated, respectively. No 30787976 hsa_circ_0002360 CircRNA Homo sapiens Adenocarcinoma of Lung LAC tissues Expression[Expression[highly expressed]-expression] qRT-PCR//Western Blot Two-hundred-eighty-five dysregulated circular transcripts were found in LAC tissues, among which 102 and 183 were either Expression[up-expression] or down regulated, respectively. No 30787976 hsa_circ_0039161 CircRNA Homo sapiens Adenocarcinoma of Lung LAC tissues Expression[Expression[highly expressed]-expression] qRT-PCR//Western Blot Two-hundred-eighty-five dysregulated circular transcripts were found in LAC tissues, among which 102 and 183 were either Expression[up-expression] or down regulated, respectively. No 30787976 hsa_circ_0000264 CircRNA Homo sapiens Adenocarcinoma of Lung LAC tissues Expression[Expression[highly expressed]-expression] qRT-PCR//Western Blot Two-hundred-eighty-five dysregulated circular transcripts were found in LAC tissues, among which 102 and 183 were either Expression[up-expression] or down regulated, respectively. No 30787976 hsa_circ_002584 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5386 No 31026505 hsa_circ_003873 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5387 No 31026505 hsa_circ_0007395 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_0000254 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_404940 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_006023 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5388 No 31026505 hsa_circ_006416 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5389 No 31026505 hsa_circ_0007845 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_005659 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5413 No 31026505 hsa_circ_006117 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5374 No 31026505 hsa_circ_007046 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5414 No 31026505 hsa_circ_0001946 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissues Expression [highly expressed] PCR Circ_0001946 expression in adjacent tissues was over 3-folds as that in tumor tissues (P < .001). Meanwhile, higher tumor circ_0001946 expression was correlated with less lymph node metastasis (P < .001) and decreased TNM stage (P = .001), but did not correlate with other clinicopathological features. Moreover, higher tumor circ_0001946 expression was associated with prolonged disease-free survival (DFS) (P < .001) and overall survival (OS) (P < .001), respectively. No 34216509 hsa_circ_0087862 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[Expression[highly expressed]-expression] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_003910 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5427 No 31026505 hsa_circ_001687 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5428 No 31026505 hsa_circ_006118 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5429 No 31026505 hsa_circ_006620 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5430 No 31026505 hsa_circ_000746 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5431 No 31026505 hsa_circ_003798 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6353 No 31026505 hsa_circ_006850 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5432 No 31026505 hsa_circ_000939 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5433 No 31026505 hsa_circ_004729 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5434 No 31026505 hsa_circ_003870 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5435 No 31026505 hsa_circ_003742 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5436 No 31026505 hsa_circ_002570 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5437 No 31026505 hsa_circ_000276 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6352 No 31026505 hsa_circ_0043800 CircRNA Homo sapiens Hepatoblastoma HB tissues and cells Expression[highly expressed] RNA Pull-Down//qRT-PCR//RIP//Transwell Assay//ChIP Circ_0043800, which was originated from STAT3, was up-regulated in HB tissues and cells. No 32493490 hsa_circ_006777 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6351 No 31026505 hsa_circ_012515 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cancerous tissues Expression[highly expressed] qRT-PCR In the cancerous tissues from NSCLC patients, NSCLC cells and gefitinib-resistant cell lines, the average expressions of hsa_circRNA_012515 increased significantly (P<0.01). No 32210630 hsa_circ_001329 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5438 No 31026505 hsa_circ_000199 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6350 No 31026505 circP4HB CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue Interaction[sponging miR-133a-5p] Northern Blot//Western Blot//qPCR//RIP//Luciferase Report Assay//Transwell Assay NSCLC tumor specimens exhibited higher circP4HB levels in comparison to paired healthy lung samples and was associated with metastatic disease and poorer survival. NSCLC tumor specimens exhibited higher circP4HB levels in comparison to paired healthy lung samples and was associated with metastatic disease and poorer survival. No 31005252 hsa_circ_001341 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6349 No 31026505 hsa_circ_11783 CircRNA Homo sapiens Breast Cancer Liver Metastases BCLM tissues,cell lines Expression[lower expressed] qRT-PCR he altered expressed circRNAs were found in BCLM tissues, compared with primary tumor tissues. These circRNAs involved in metastatic related signaling pathways. Hsa_circ_21439 and hsa_circ_11784 were verified to be the most significantly Expression[Expression[up-expression]-expression]- and Expression[down-expression]regulated circRNAs in both BCLM tissues and cells. No 31293174 hsa_circ_000872 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5439 No 31026505 hsa_circ_002231 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5440 No 31026505 hsa_circ_21439 CircRNA Homo sapiens Breast Cancer Liver Metastases BCLM tissues,cell lines Expression[Expression[highly expressed]-expression] qRT-PCR he altered expressed circRNAs were found in BCLM tissues, compared with primary tumor tissues. These circRNAs involved in metastatic related signaling pathways. Hsa_circ_21439 and hsa_circ_11783 were verified to be the most significantly Expression[Expression[up-expression]-expression]- and Expression[down-expression]regulated circRNAs in both BCLM tissues and cells. No 31293174 hsa_circ_0105015 CircRNA Homo sapiens Essential Hypertension EH patients Interaction(hsa-miR-637) qRT-PCR//Microarray Hsa_circ_0105015 has two predicted binding sites with hsa-miR-637. The relative expression of hsa_circ_0105015 in EH patients was significantly higher than healthy controls (P = .002), and similar results appeared in TNF-α-induced endothelial cells. The area under the curve after hsa_circ_0105015 combined with hsa-miR-637 was 0.703, P < .001. No 33236350 hsa_circ_0012077 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[Expression[highly expressed]-expression] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_0018659 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[Expression[highly expressed]-expression] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_0026457 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[Expression[highly expressed]-expression] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_0014887 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_0087571 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_005640 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5415 No 31026505 hsa_circ_0005735 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_0000685 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_400660 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_000439 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5416 No 31026505 hsa_circ_002705 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6356 No 31026505 hsa_circ_003028 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5417 No 31026505 hsa_circ_007059 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5418 No 31026505 hsa_circ_006497 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6355 No 31026505 hsa_circ_005624 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5419 No 31026505 hsa_circ_003848 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5420 No 31026505 hsa_circ_0001355 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_0081069 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[Expression[highly expressed]-expression] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_0082352 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_006973 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5421 No 31026505 hsa_circ_006921 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6354 No 31026505 hsa_circ_000604 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5422 No 31026505 hsa_circ_005730 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5423 No 31026505 hsa_circ_004348 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5424 No 31026505 hsa_circ_0001627 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[lower expressed] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_0000559 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[Expression[highly expressed]-expression] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_0008029 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[Expression[highly expressed]-expression] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_001958 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5425 No 31026505 hsa_circ_001982 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5426 No 31026505 hsa_circ_0087856 CircRNA Homo sapiens Demyelinating Diseases Cerebrospinal Fluid Expression[Expression[highly expressed]-expression] qRT-PCR Volcano plot graphs (Figure 2) showed that 26 exo-circRNAs were differentially expressed in the CSF exosomes of patients with immune-mediated demyelinating disease. The expression profiles were demonstrated by a cluster heat map (Figure 3). Among these 26 exo-circRNAs, 8 were Expression[Expression[up-expression]-expression]regulated, and 18 were Expression[down-expression]regulated (Table 2). No 31611906 hsa_circ_005670 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5375 No 31026505 hsa_circ_0007761 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung serum Expression[lower expressed] qRT-PCR//RNA-seq In comparison with NSCLC cases, circ_0047921 ( P < 0.001) was significantly up-regulated in COPD controls, whereas circ_0056285 was up-regulated ( P = 0.003) and circ_0007761 ( P = 0.019) was down-regulated in TB controls. No 32535085 hsa_circ_0007445 CircRNA Homo sapiens severe pre-eclampsia Placental sample Expression[highly expressed] qRT-PCR//RIP//Western Blot We selected 7 of the top 10 distinctly Expression[up-expression]- or downregulated circRNAs for further validation by qRT-PCR. One-generation sequencing of qRT-PCR products was conducted to detect the junction reads of selected circRNAs. Among them, the qRT-PCR results of 6 DE-circRNAs (hsa_circ_0002888, hsa_circ_0007445, hsa_circ_0007611, hsa_circ_0011460, hsa_circ_0012737, hsa_circ_0017068) were consistent with the RNA-Seq data (Fig. 2), while one circRNA-hsa_circ_0017068 presented the opposite expression trend between the RNA-Seq data and qRT-PCR results. No 31487644 hsa_circ_001086 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5318 No 31026505 hsa_circ_002018 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5291 No 31026505 hsa_circ_001109 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5292 No 31026505 hsa_circ_005306 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5293 No 31026505 hsa_circ_007115 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5294 No 31026505 hsa_circ_003606 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5295 No 31026505 hsa_circ_002655 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5296 No 31026505 hsa_circ_000229 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5297 No 31026505 hsa_circ_002758 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5298 No 31026505 hsa_circ_003545 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5299 No 31026505 hsa_circ_006449 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5300 No 31026505 hsa_circ_007230 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5301 No 31026505 hsa_circ_003813 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5302 No 31026505 hsa_circ_006339 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5303 No 31026505 hsa_circ_001432 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5304 No 31026505 hsa_circ_000160 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5305 No 31026505 hsa_circ_007032 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5306 No 31026505 hsa_circ_003233 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5307 No 31026505 hsa_circ_006720 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5308 No 31026505 hsa_circ_007031 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5309 No 31026505 hsa_circ_003647 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5310 No 31026505 hsa_circ_003913 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5311 No 31026505 hsa_circ_001623 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5312 No 31026505 hsa_circ_0004417 CircRNA Homo sapiens Adenocarcinoma of Lung LAC tissues Expression[lower expressed] qRT-PCR//Western Blot Two-hundred-eighty-five dysregulated circular transcripts were found in LAC tissues, among which 102 and 183 were either Expression[up-expression] or down regulated, respectively. No 30787976 hsa_circ_005053 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5313 No 31026505 hsa_circ_005163 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5314 No 31026505 hsa_circ_004116 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5315 No 31026505 hsa_circ_003876 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5316 No 31026505 hsa_circ_002977 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5290 No 31026505 hsa_circ_004732 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5289 No 31026505 hsa_circ_004579 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5288 No 31026505 hsa_circ_003675 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5274 No 31026505 hsa_circ_0002888 CircRNA Homo sapiens severe pre-eclampsia Placental sample Expression[highly expressed] qRT-PCR//RIP//Western Blot We selected 7 of the top 10 distinctly Expression[up-expression]- or downregulated circRNAs for further validation by qRT-PCR. One-generation sequencing of qRT-PCR products was conducted to detect the junction reads of selected circRNAs. Among them, the qRT-PCR results of 6 DE-circRNAs (hsa_circ_0002888, hsa_circ_0007445, hsa_circ_0007611, hsa_circ_0011460, hsa_circ_0012737, hsa_circ_0017068) were consistent with the RNA-Seq data (Fig. 2), while one circRNA-hsa_circ_0017068 presented the opposite expression trend between the RNA-Seq data and qRT-PCR results. No 31487644 hsa_circ_000129 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5267 No 31026505 hsa_circ_002139 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5268 No 31026505 hsa_circ_007212 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5269 No 31026505 hsa_circ_003061 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5270 No 31026505 hsa_circ_003915 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5271 No 31026505 hsa_circ_0007385 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue Expression[highly expressed] qRT-PCR Hsa_circ_0007385 was upregulated in tumor tissue compared with adjacent non-tumor tissue (P < .001). Tumor hsa_circ_0007385 high expression correlated with lymph node metastasis (P = .007) and higher TNM stage (P = .004). In addition, DFS (P = .028) and OS (P = .008) were both less favorable in patients with tumor hsa_circ_0007385 high expression compared to patients with tumor hsa_circ_0007385 low expression. No 32666646 hsa_circ_004355 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5272 No 31026505 hsa_circ_0011460 CircRNA Homo sapiens severe pre-eclampsia Placental sample Expression[highly expressed] qRT-PCR//RIP//Western Blot We selected 7 of the top 10 distinctly Expression[up-expression]- or downregulated circRNAs for further validation by qRT-PCR. One-generation sequencing of qRT-PCR products was conducted to detect the junction reads of selected circRNAs. Among them, the qRT-PCR results of 6 DE-circRNAs (hsa_circ_0002888, hsa_circ_0007445, hsa_circ_0007611, hsa_circ_0011460, hsa_circ_0012737, hsa_circ_0017068) were consistent with the RNA-Seq data (Fig. 2), while one circRNA-hsa_circ_0017068 presented the opposite expression trend between the RNA-Seq data and qRT-PCR results. No 31487644 hsa_circ_0004777 CircRNA Homo sapiens Adenocarcinoma of Lung LAC tissues Expression[lower expressed] qRT-PCR//Western Blot Two-hundred-eighty-five dysregulated circular transcripts were found in LAC tissues, among which 102 and 183 were either Expression[up-expression] or down regulated, respectively. No 30787976 hsa_circ_003245 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5273 No 31026505 hsa_circ_0001320 CircRNA Homo sapiens Adenocarcinoma of Lung LAC tissues Expression[lower expressed] qRT-PCR//Western Blot Two-hundred-eighty-five dysregulated circular transcripts were found in LAC tissues, among which 102 and 183 were either Expression[up-expression] or down regulated, respectively. No 30787976 hsa_circ_0003176 CircRNA Homo sapiens Adenocarcinoma of Lung LAC tissues Expression[lower expressed] qRT-PCR//Western Blot Two-hundred-eighty-five dysregulated circular transcripts were found in LAC tissues, among which 102 and 183 were either Expression[up-expression] or down regulated, respectively. No 30787976 hsa_circ_001850 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5287 No 31026505 hsa_circ_000782 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5275 No 31026505 hsa_circ_001381 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5276 No 31026505 hsa_circ_006816 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5277 No 31026505 hsa_circ_003313 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5278 No 31026505 hsa_circ_005096 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5279 No 31026505 hsa_circ_001830 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5280 No 31026505 hsa_circ_003151 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5281 No 31026505 hsa_circ_004177 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5282 No 31026505 hsa_circ_000921 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5283 No 31026505 hsa_circ_004670 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5284 No 31026505 hsa_circ_003462 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5285 No 31026505 hsa_circ_005248 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5286 No 31026505 hsa_circ_001526 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5317 No 31026505 hsa_circ_005310 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5319 No 31026505 hsa_circ_003695 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5373 No 31026505 hsa_circ_003349 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5320 No 31026505 hsa_circ_003704 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5347 No 31026505 hsa_circ_004200 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5348 No 31026505 hsa_circ_000595 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5349 No 31026505 hsa_circ_004605 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5350 No 31026505 hsa_circ_001033 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5351 No 31026505 hsa_circ_002647 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5352 No 31026505 hsa_circ_005989 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5353 No 31026505 hsa_circ_006438 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5354 No 31026505 hsa_circ_000060 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5355 No 31026505 hsa_circ_003008 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5356 No 31026505 hsa_circ_003881 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5357 No 31026505 hsa_circ_005305 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5358 No 31026505 hsa_circ_002626 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5359 No 31026505 hsa_circ_001256 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5360 No 31026505 hsa_circ_001497 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5361 No 31026505 hsa_circ_005566 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5362 No 31026505 hsa_circ_000777 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5363 No 31026505 hsa_circ_005355 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5364 No 31026505 hsa_circ_001483 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5365 No 31026505 hsa_circ_002938 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5366 No 31026505 hsa_circ_006849 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5367 No 31026505 hsa_circ_006116 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5368 No 31026505 hsa_circ_007185 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5369 No 31026505 hsa_circ_002635 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5370 No 31026505 hsa_circ_005650 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5371 No 31026505 hsa_circ_005520 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5372 No 31026505 hsa_circ_003518 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6362 No 31026505 hsa_circ_004171 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5346 No 31026505 hsa_circ_006126 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5345 No 31026505 hsa_circ_006629 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5344 No 31026505 hsa_circ_001084 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5332 No 31026505 hsa_circ_003341 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5321 No 31026505 hsa_circ_005274 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5322 No 31026505 hsa_circ_003388 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5323 No 31026505 hsa_circ_005104 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5324 No 31026505 hsa_circ_000260 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5325 No 31026505 hsa_circ_005960 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5326 No 31026505 hsa_circ_004376 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5327 No 31026505 hsa_circ_005245 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5328 No 31026505 hsa_circ_005188 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5329 No 31026505 hsa_circ_0047921 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung serum Expression[highly expressed] qRT-PCR//RNA-seq In comparison with NSCLC cases, circ_0047921 ( P < 0.001) was significantly up-regulated in COPD controls, whereas circ_0056285 was up-regulated ( P = 0.003) and circ_0007761 ( P = 0.017) was down-regulated in TB controls. No 32535085 hsa_circ_002105 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5330 No 31026505 hsa_circ_003911 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5331 No 31026505 hsa_circ_006524 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5333 No 31026505 hsa_circ_007060 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5343 No 31026505 hsa_circ_000522 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5334 No 31026505 hsa_circ_002960 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5335 No 31026505 hsa_circ_007035 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5336 No 31026505 hsa_circ_001821 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5337 No 31026505 hsa_circ_005226 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5338 No 31026505 hsa_circ_0056285 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung serum Expression[highly expressed] qRT-PCR//RNA-seq In comparison with NSCLC cases, circ_0047921 ( P < 0.001) was significantly up-regulated in COPD controls, whereas circ_0056285 was up-regulated ( P = 0.003) and circ_0007761 ( P = 0.018) was down-regulated in TB controls. No 32535085 hsa_circ_004490 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5339 No 31026505 hsa_circ_003444 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6363 No 31026505 hsa_circ_0004062 CircRNA Homo sapiens Adenocarcinoma of Lung LAC tissues Expression[lower expressed] qRT-PCR//Western Blot Two-hundred-eighty-five dysregulated circular transcripts were found in LAC tissues, among which 102 and 183 were either Expression[up-expression] or down regulated, respectively. No 30787976 hsa_circ_000248 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5340 No 31026505 hsa_circ_001093 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5341 No 31026505 hsa_circ_005686 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5342 No 31026505 hsa_circ_005339 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5660 No 31026505 hsa_circ_007252 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .129) were identified No 31261542 hsa_circ_005495 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4041 No 31026505 hsa_circ_002629 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5962 No 31026505 hsa_circ_100191 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_102854 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_026358 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_000484 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5964 No 31026505 hsa_circ_003461 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5965 No 31026505 hsa_circ_002641 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5966 No 31026505 hsa_circ_075650 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_103809 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_401782 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_004570 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5967 No 31026505 hsa_circ_002722 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5968 No 31026505 hsa_circ_002773 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6203 No 31026505 hsa_circ_406826 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_101001 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_082680 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_102039 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_404013 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_001987 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5969 No 31026505 hsa_circ_006428 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5970 No 31026505 hsa_circ_000319 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_000320 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_004341 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5971 No 31026505 hsa_circ_000780 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_087212 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_000317 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_003370 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5972 No 31026505 hsa_circ_006309 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5973 No 31026505 hsa_circ_005055 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5963 No 31026505 hsa_circ_004315 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5961 No 31026505 hsa_circ_004870 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5994 No 31026505 hsa_circ_003658 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5960 No 31026505 hsa_circ_006466 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5946 No 31026505 circNSUN2 CircRNA Homo sapiens Colorectal Neoplasms colorectal carcinoma tissues,cell lines Expression[highly expressed] qRT-PCR CircNSUN2 was clearly upregulated in three CRC tumor tissues, five CRC cell lines compared to normal colorectal tissue, particularly in HCT116 cells (Supplementary Fig. 1a). No 31619685 hsa_circ_002088 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5947 No 31026505 hsa_circ_002565 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5948 No 31026505 hsa_circ_003711 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5949 No 31026505 hsa_circ_001680 CircRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[highly expressed] qRT-PCR Circ_001680 was more highly expressed in of CRC tissue than in matched adjacent normal tissues from the same patients. No 32005118 hsa_circ_004650 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5950 No 31026505 hsa_circ_003892 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6206 No 31026505 hsa_circ_001024 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5951 No 31026505 hsa_circ_0000919 CircRNA Homo sapiens tongue squamous cell carcinoma five pairs of TSCC and adjacent (Ctrl) tissues Regulation qRT-PCR//Survival Analysis//Bioinformatics Analysis//Microarray These findings were validated by RT-qPCR analysis and the results demonstrated that the expression levels of 9/10 selected candidate DEcircRNAs (circ_0020048, circ_0000919, circ_0004525, circ_0002113, circ_0004029, circ_0004503, circ_0008752, circ_0002300 and circ_0001811) were dysregulated in TSCC tissues compared with Ctrl tissues. The expression levels of five DEcircRNAs (circ_0004503, circ_0008752, circ_0002300, circ_0020048 and circ_0000919) were associated with pathological grade or tumor clinical stage. Notably, only the expression levels of one DEcircRNA (circ_0000919) were associated with decreased OS. No 35782902 hsa_circ_001360 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6205 No 31026505 hsa_circ_000371 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5952 No 31026505 hsa_circ_103670 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_004390 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_104172 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_404013 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_006158 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6204 No 31026505 hsa_circ_001937 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_005571 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5953 No 31026505 hsa_circ_100872 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_006178 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5954 No 31026505 hsa_circ_003836 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5955 No 31026505 hsa_circ_003779 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5956 No 31026505 hsa_circ_003251 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[lower expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_005660 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5957 No 31026505 hsa_circ_000350 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5958 No 31026505 hsa_circ_006286 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5959 No 31026505 hsa_circ_036186 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_062557 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_001581 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5974 No 31026505 hsa_circ_100053 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_003231 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5983 No 31026505 hsa_circ_000601 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5984 No 31026505 hsa_circ_000217 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6195 No 31026505 hsa_circ_030162 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_003560 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6194 No 31026505 hsa_circ_006783 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6193 No 31026505 hsa_circ_006587 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5985 No 31026505 hsa_circ_006481 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5986 No 31026505 hsa_circ_003129 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6192 No 31026505 hsa_circ_000357 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6191 No 31026505 hsa_circ_0000231 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and adjacent tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq "The results showed that all six circRNAs in 20 paired tongue fresh tissues were expressed in TSCC higher than paracancer, consistent with the high‐throughput data (Figure 11)" No 30269358 hsa_circ_0005615 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and adjacent tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq "The results showed that all six circRNAs in 20 paired tongue fresh tissues were expressed in TSCC higher than paracancer, consistent with the high‐throughput data (Figure 10)" No 30269358 hsa_circ_0001742 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and adjacent tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq "The results showed that all six circRNAs in 20 paired tongue fresh tissues were expressed in TSCC higher than paracancer, consistent with the high‐throughput data (Figure 9)" No 30269358 hsa_circ_0007976 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and adjacent tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq "The results showed that all six circRNAs in 20 paired tongue fresh tissues were expressed in TSCC higher than paracancer, consistent with the high‐throughput data (Figure 8)" No 30269358 hsa_circ_001729 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_0002837 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and adjacent tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq "The results showed that all six circRNAs in 20 paired tongue fresh tissues were expressed in TSCC higher than paracancer, consistent with the high‐throughput data (Figure 7)" No 30269358 hsa_circ_0002162 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues and adjacent tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq "The results showed that all six circRNAs in 20 paired tongue fresh tissues were expressed in TSCC higher than paracancer, consistent with the high‐throughput data (Figure 6)" No 30269358 hsa_circ_002475 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5987 No 31026505 hsa_circ_006502 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5988 No 31026505 hsa_circ_006942 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6190 No 31026505 hsa_circ_087212 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_037767 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_006515 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6189 No 31026505 hsa_circ_005699 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5989 No 31026505 hsa_circ_004664 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5990 No 31026505 hsa_circ_003092 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5991 No 31026505 hsa_circ_000687 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5992 No 31026505 hsa_circ_000235 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5982 No 31026505 hsa_circ_004054 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6196 No 31026505 hsa_circ_004678 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5981 No 31026505 hsa_circ_006146 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6200 No 31026505 hsa_circ_407284 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_006853 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5975 No 31026505 hsa_circ_006226 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_067130 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_103121 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_404905 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_101323 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_404474 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_067209 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_002836 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6202 No 31026505 hsa_circ_006514 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6201 No 31026505 hsa_circ_402089 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_081069 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_004662 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_002019 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5976 No 31026505 hsa_circ_014280 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_013058 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_002253 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5977 No 31026505 hsa_circ_006183 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5978 No 31026505 hsa_circ_004406 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5979 No 31026505 hsa_circ_004998 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5980 No 31026505 hsa_circ_001901 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6199 No 31026505 hsa_circ_045179 CircRNA Homo sapiens tongue squamous cell carcinoma tumor tissues Expression[highly expressed] qPCR//Migration Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Microarray The top 15 upregulated and top 15 downregulated circRNAs, combined with the detailed molecular information, are presented in Tables III and ?andIV.IV. No 32319610 hsa_circ_0001742 CircRNA Homo sapiens tongue squamous cell carcinoma TSCC tissues Expression[highly expressed] qRT-PCR Circ_0001742 expression was increased in TSCC tumor tissue compared with adjacent tissue, and it presented good value in discriminating tumor tissue from adjacent tissue (area under the curve (AUC): 0.870, 95% CI: 0.831-0.910). Tumor high circ_0001742 expression was associated with higher T stage, N stage, and TNM stage, but not age, gender, or pathological grade. Furthermore, OS was reduced in tumor circ_0001742 high patients compared with tumor circ_0001742 low patients; moreover, OS was the shortest in tumor circ_0001742 high+++ patients, followed by tumor circ_0001742 high++ patients and tumor circ_0001742 high+ patients, and the longest in tumor circ_0001742 low patients. No 32463532 hsa_circ_000314 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6198 No 31026505 hsa_circ_000120 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6197 No 31026505 hsa_circ_006889 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5945 No 31026505 hsa_circ_007038 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5944 No 31026505 hsa_circ_003717 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5943 No 31026505 hsa_circ_001241 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5922 No 31026505 hsa_circ_003241 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5908 No 31026505 hsa_circ_000800 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5909 No 31026505 hsa_circ_004394 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5910 No 31026505 hsa_circ_0005754 CircRNA Homo sapiens lung squamous cell carcinoma Blood Expression[lower expressed] qRT-PCR//RNA-seq By screening expression level and fold change of exosomal circRNAs, we listed top 10 differentially expressed circRNAs and their detailed information in Table 1. No 32309852 hsa_circ_006296 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5911 No 31026505 hsa_circ_0025580 CircRNA Homo sapiens lung squamous cell carcinoma Blood Expression[highly expressed] qRT-PCR//RNA-seq By screening expression level and fold change of exosomal circRNAs, we listed top 10 differentially expressed circRNAs and their detailed information in Table 1. No 32309852 hsa_circ_0013226 CircRNA Homo sapiens lung squamous cell carcinoma Blood Expression[lower expressed] qRT-PCR//RNA-seq By screening expression level and fold change of exosomal circRNAs, we listed top 10 differentially expressed circRNAs and their detailed information in Table 1. No 32309852 hsa_circ_000124 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5912 No 31026505 hsa_circ_006133 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5913 No 31026505 hsa_circ_0014235 CircRNA Homo sapiens lung squamous cell carcinoma Blood Expression[highly expressed] qRT-PCR//RNA-seq By screening expression level and fold change of exosomal circRNAs, we listed top 10 differentially expressed circRNAs and their detailed information in Table 1. No 32309852 hsa_circ_0018430 CircRNA Homo sapiens lung squamous cell carcinoma Blood Expression[highly expressed] qRT-PCR//RNA-seq By screening expression level and fold change of exosomal circRNAs, we listed top 10 differentially expressed circRNAs and their detailed information in Table 1. No 32309852 circPDK1 CircRNA Homo sapiens lung squamous cell carcinoma LSCC tissue Expression[highly expressed] qRT-PCR CircPDK1 was identified to be overexpressed (P<0.01) in LSCC. Through analysis in study cohort, circPDK1low patients (less than the mean expression, n=124) showed more lymph nodes metastasis (P=0.025), more vascular invasion (VI) (P=0.047), more visceral pleural invasion (VPI) (P=0.015) and poorer prognosis (P=0.003) than circPDK1high ones (n=108). Univariate and multivariate analysis showed that circPDK1, T staging, LN status, age, and SCCAg were significant prognostic factors for RFS and OS. The prognostic model based on these factors showed the concordance index (C-index) of 0.8214 and 0.8359 for predicting 5-year RFS and OS, respectively. No 32010569 hsa_circ_001451 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5914 No 31026505 hsa_circ_000483 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5915 No 31026505 hsa_circ_001328 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5916 No 31026505 hsa_circ_0000826 CircRNA Homo sapiens Colorectal Liver Metastases CRC tissue Expression[highly expressed] qRT-PCR//RNA-seq After verified some candidates in another 40 CRC and CRC-m samples by qRT-PCR, we further demonstrated that circRNA_0001178 and circRNA_0000826 were significantly upregulated in CRC-m tissues, and both of them had the potential for diagnosing liver metastases from colorectal cancer. No 30630466 hsa_circ_0001178 CircRNA Homo sapiens Colorectal Liver Metastases CRC tissue Expression[highly expressed] qRT-PCR//RNA-seq After verified some candidates in another 40 CRC and CRC-m samples by qRT-PCR, we further demonstrated that circRNA_0001178 and circRNA_0000826 were significantly upregulated in CRC-m tissues, and both of them had the potential for diagnosing liver metastases from colorectal cancer. No 30630466 hsa_circ_000832 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6219 No 31026505 hsa_circ_000831 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6218 No 31026505 hsa_circ_003385 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5917 No 31026505 hsa_circ_003438 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5918 No 31026505 hsa_circ_004083 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5919 No 31026505 hsa_circ_001858 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5920 No 31026505 hsa_circ_006780 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6217 No 31026505 hsa_circ_003783 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5921 No 31026505 hsa_circ_007121 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6216 No 31026505 circEZH2E2 /E3 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cells Interaction(EZH2-circEZH2E2/E3 -miR363/miR708-EZH2 regulatory loop) In Vivo Experiment//qRT-PCR//Wound Healing Assay//Transwell Assay We here report the identification of circEZH2E2/E3 that is derived from exons 2 and 3 of the EZH2 gene and overexpressed in PCa.These findings show a novel autoenhancing EZH2-circEZH2E2/E3 -miR363/miR708-EZH2 regulatory loop, by which circEZH2E2/E3 plays important roles in PCa tumorigenesis and progression by upregulating EZH2, and may have potential diagnostic, prognostic, and therapeutic uses in PCa management. Overexpression of circEZH2E2/E3 is significantly correlated with higher tumor grade, tumor progression, and unfavorable progression-free and disease-specific survival in PCa patients. No 36519785 hsa_circ_005307 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5907 No 31026505 hsa_circ_0043638 CircRNA Homo sapiens lung squamous cell carcinoma Blood Expression[highly expressed] qRT-PCR//RNA-seq By screening expression level and fold change of exosomal circRNAs, we listed top 10 differentially expressed circRNAs and their detailed information in Table 1. No 32309852 hsa_circ_0019069 CircRNA Homo sapiens lung squamous cell carcinoma Blood Expression[lower expressed] qRT-PCR//RNA-seq By screening expression level and fold change of exosomal circRNAs, we listed top 10 differentially expressed circRNAs and their detailed information in Table 1. No 32309852 hsa_circ_001095 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5896 No 31026505 hsa_circ_005951 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5887 No 31026505 hsa_circ_000545 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5888 No 31026505 hsa_circ_004771 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5889 No 31026505 hsa_circ_006550 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5890 No 31026505 hsa_circ_005061 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5891 No 31026505 hsa_circ_007259 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5892 No 31026505 hsa_circ_000718 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6222 No 31026505 hsa_circ_006027 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5893 No 31026505 hsa_circ_002871 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6221 No 31026505 hsa_circ_001254 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6220 No 31026505 hsa_circ_000941 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5894 No 31026505 hsa_circ_006910 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5895 No 31026505 hsa_circ_004898 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5897 No 31026505 hsa_circ_0084709 CircRNA Homo sapiens lung squamous cell carcinoma Blood Expression[lower expressed] qRT-PCR//RNA-seq By screening expression level and fold change of exosomal circRNAs, we listed top 10 differentially expressed circRNAs and their detailed information in Table 1. No 32309852 hsa_circ_003931 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5898 No 31026505 hsa_circ_002737 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5899 No 31026505 hsa_circ_003787 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5900 No 31026505 hsa_circ_002112 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5901 No 31026505 hsa_circ_007150 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5902 No 31026505 hsa_circ_003744 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5903 No 31026505 hsa_circ_001463 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5904 No 31026505 hsa_circ_0026403 CircRNA Homo sapiens lung squamous cell carcinoma Blood Expression[highly expressed] qRT-PCR//RNA-seq By screening expression level and fold change of exosomal circRNAs, we listed top 10 differentially expressed circRNAs and their detailed information in Table 1. No 32309852 hsa_circ_006578 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5905 No 31026505 hsa_circ_0074027 CircRNA Homo sapiens lung squamous cell carcinoma Blood Expression[highly expressed] qRT-PCR//RNA-seq By screening expression level and fold change of exosomal circRNAs, we listed top 10 differentially expressed circRNAs and their detailed information in Table 1. No 32309852 hsa_circ_004427 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5906 No 31026505 hsa_circ_0057558 CircRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues and cell lines Interaction(miR-206/USP33/c-Myc Axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//IP circ_0057558 gives an impetus to cell proliferation and cell cycle control in prostate cancer cell lines by sponging miR-206 and positively regulating the transcription of the miR-206 target gene USP33. No 33718387 BTBD7_hsa_circ_0000563 CircRNA Homo sapiens Coronary Artery Disease peripheral blood mononuclear cells Expression(lower expressed) qRT-PCR//Bioinformatics Analysis//Western Blot In the present study, BTBD7_hsa_circ_0000563 was verified as a circular RNA in the PBMCs of CAD patients. The expression level of BTBD7_hsa_circ_0000563 in the CAD group was significantly lower than that in the control group. The area under the ROC curve was 0.690. ChIRP-MS found seven proteins that were directly bound to BTBD7_hsa_circ_0000563. Bioinformatic analysis of these seven proteins showed that the mitophagy and DNA repair pathways were enriched. These proteins interacted with each other to a certain extent. No 36329387 hsa_circ_004419 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5923 No 31026505 hsa_circ_002803 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6207 No 31026505 hsa_circ_000341 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5924 No 31026505 rno_circ_000740 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[highly expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 hsa_circ_006904 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6211 No 31026505 rno_circ_011190 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[highly expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 rno_circ_014301 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[highly expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 rno_circ_000793 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[highly expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 hsa_circ_004084 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5941 No 31026505 rno_circ_013859 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[highly expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 hsa_circ_001806 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6210 No 31026505 rno_circ_013860 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[highly expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 mmu_circ_31436 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[highly expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 hsa_circ_004902 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6209 No 31026505 rno_circ_008695 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[highly expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 rno_circ_001731 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[lower expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 hsa_circ_003638 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5942 No 31026505 rno_circ_017447 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[lower expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 rno_circ_008565 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[lower expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 rno_circ_011560 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[lower expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 mmu_circ_24828 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[lower expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 hsa_circ_005205 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6208 No 31026505 rno_circ_008424 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[lower expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 rno_circ_007118 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[lower expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 mmu_circ_39417 CircRNA Homo sapiens Diabetes Mellitus, Type 2 islet β-cells Expression[lower expressed] qRT-PCR//Microarray " A total of 8117 circRNAs were detected by the circRNA microarray (Figure 2(a)). We identified 825 circRNAs that were differentially expressed between the control and T2DM rats. Three hundred and eighty-eight of these circRNAs were upregulated, and 437 were downregulated in T2DM rats (Figure 2(b)). Some differentially expressed circRNAs are shown in Table 2. " No 31249590 circCCNB1 CircRNA Homo sapiens Diabetes Mellitus, Type 2 Serum Expression[highly expressed] qRT-PCR//ELISA From the results, circ_CCNB1 was significantly increased while circ_0009024 was decreased in serum samples from T2DM patients. No 32633001 circβ-catenin CircRNA Homo sapiens Liver Neoplasms HCC tissues and corresponding adjacent normal tissues,cell lines(SW620、Huh7、HepG2 , PLC/PRF/5 ) Interaction[Wnt/β-catenin pathway] Northern Blot//Western Blot//qRT-PCR//Luciferase Report Assay//RNA-seq we identify a novel circRNA derived from β-catenin, a well-characterized oncogene in liver cancer. This is the first report that circRNA can encode a novel protein isoform, which subsequently promotes tumor growth through activation of the Wnt/β-catenin pathway in liver cancer.  No 31027518 hsa_circ_0054633 CircRNA Homo sapiens Diabetes Mellitus, Type 2 serum of patients with T2DM Expression(highly expressed) qRT-PCR We found that serum expression of hsa_circ_0054633 was dramatically increased in patients with T2DM. Serum hsa_circ_0054633 levels had high sensitivity (75.0%) and specificity (95.5%) for differentiating T2DM. Besides, serum expression of circ_0054633 was significantly correlated with fasting blood glucose (r=0.698), hemoglobin A1c (r=0.503) and low-density lipoprotein (r=0.399). No 33653785 hsa_circ_0071106 CircRNA Homo sapiens Diabetes Mellitus, Type 2 101 pairs of T2DM and controls Expression(highly expressed) qRT-PCR Compared with healthy controls, the expression levels of hsa_circ_0071106, hsa_circ_0000284, hsa_circ_0071271, hsa-miR-29a-5p, hsa-miR-3690, hsa-miR-607, lncRNA MEG3 and lncRNA TUG1were higher in T2DM (all P < 0.05). The AUCs of hsa_circ_0071106, hsa-miR-607 and lncRNA TUG1 for diagnosis of T2DM were 0.563,0.645 and 0.642, respectively. No 35876150 hsa_circ_0009024 CircRNA Homo sapiens Diabetes Mellitus Serum Expression[lower expressed] qRT-PCR//ELISA From the results, circ_CCNB1 was significantly increased while circ_0009024 was decreased in serum samples from T2DM patients. No 32633001 hsa_circ_001107 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5940 No 31026505 hsa_circ_006175 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5939 No 31026505 hsa_circ_005212 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5938 No 31026505 hsa_circ_006115 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6214 No 31026505 hsa_circ_005546 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5925 No 31026505 hsa_circ_003585 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5926 No 31026505 hsa_circ_000611 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5927 No 31026505 hsa_circ_003192 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5928 No 31026505 hsa_circ_006687 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5929 No 31026505 hsa_circ_001509 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6215 No 31026505 circZNF609 CircRNA Homo sapiens Coronary Artery Disease blood Expression[lower expressed] qRT-PCR The expression level of circZNF609 in PBLs of CAD patients was significantly decreased compared with the controls (the fold changes of 0.4133, P<0.0001). No 32647666 hsa_circ_0000676 CircRNA Homo sapiens Coronary Artery Disease blood Expression[highly expressed] qRT-PCR//circRNA-seq The results showed that hsa_circ_0005540 and hsa_circ_0000676 were significantly increased in CAD patients as compared with non-CAD controls (P < 0.05, Figures 2(a) and 2(b)). No 32670434 hsa_circ_0005540 CircRNA Homo sapiens Coronary Artery Disease blood Expression[highly expressed] qRT-PCR//circRNA-seq The results showed that hsa_circ_0005540 and hsa_circ_0000676 were significantly increased in CAD patients as compared with non-CAD controls (P < 0.05, Figures 2(a) and 2(b)). No 32670434 hsa_circ_0004104 CircRNA Homo sapiens Coronary Artery Disease blood Expression[highly expressed] qRT-PCR//Microarray A total of 624 circRNAs and 171 circRNAs were significantly upregulated and downregulated, respectively, in CAD patients relative to controls. Hsa_circ_0001879 and hsa_circ_0004105 were validated to be significantly upregulated in large cohorts. No 31103880 hsa_circ_000571 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5930 No 31026505 hsa_circ_0001879 CircRNA Homo sapiens Coronary Artery Disease blood Expression[highly expressed] qRT-PCR//Microarray A total of 624 circRNAs and 171 circRNAs were significantly upregulated and downregulated, respectively, in CAD patients relative to controls. Hsa_circ_0001879 and hsa_circ_0004104 were validated to be significantly upregulated in large cohorts. No 31103880 hsa_circ_006579 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6213 No 31026505 hsa_circ_006674 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5937 No 31026505 circCDR1AS CircRNA Homo sapiens Prostatic Neoplasms 25 PCa tissues and 25 BPH samples Expression(highly expressed) qRT-PCR The results revealed that expression of circCDR1AS was significantly elevated in PCa compared with the BPH (p < 0.05). We also observed that PCa patients over the age of 60 had a higher expression of the circCDR1AS than patients under the age of 60 (p = 0.017). Moreover, a lower expression level of circHIAT1 was found in the PCa than BPH tissues (p < 0.05), and finally, the findings indicated that the area under the curve (AUC) of circCDR1AS was 0.848, with 92% sensitivity and 76% specificity, as well as an AUC of 0.828, with the 80% sensitivity and 76% specificity for circHIAT1. No 35007362 circHIAT1 CircRNA Homo sapiens Prostatic Neoplasms 25 PCa tissues and 25 BPH samples Expression(lower expressed) qRT-PCR The results revealed that expression of circCDR1AS was significantly elevated in PCa compared with the BPH (p < 0.05). We also observed that PCa patients over the age of 60 had a higher expression of the circCDR1AS than patients under the age of 60 (p = 0.017). Moreover, a lower expression level of circHIAT1 was found in the PCa than BPH tissues (p < 0.05), and finally, the findings indicated that the area under the curve (AUC) of circCDR1AS was 0.848, with 92% sensitivity and 76% specificity, as well as an AUC of 0.828, with the 80% sensitivity and 76% specificity for circHIAT1. No 35007362 hsa_circ_003869 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5931 No 31026505 hsa_circ_000312 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5932 No 31026505 hsa_circ_001693 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5933 No 31026505 hsa_circ_003962 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5934 No 31026505 hsa_circ_000652 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6212 No 31026505 hsa_circ_0043603 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma blood Expression[lower expressed] qRT-PCR//Microarray 3 circRNAs (hsa_circ_0062459, hsa_circ_0001946, and hsa_circ_0043603) were also detected in plasma and 2 of them except hsa_circ_0062459 could be used as diagnostic biomarkers and found in exosome of cell-conditioned culture conditioned media. No 30674324 hsa_circ_0001946 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma blood Expression[lower expressed] qRT-PCR//Microarray 3 circRNAs (hsa_circ_0062459, hsa_circ_0001946, and hsa_circ_0043603) were also detected in plasma and 2 of them except hsa_circ_0062459 could be used as diagnostic biomarkers and found in exosome of cell-conditioned culture conditioned media. No 30674324 hsa_circ_006086 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5935 No 31026505 hsa_circ_002469 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5936 No 31026505 hsa_circ_0062459 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma blood Expression[highly expressed] qRT-PCR//Microarray 3 circRNAs (hsa_circ_0062459, hsa_circ_0001946, and hsa_circ_0043603) were also detected in plasma and 2 of them except hsa_circ_0062459 could be used as diagnostic biomarkers and found in exosome of cell-conditioned culture conditioned media. No 30674324 hsa_circ_001527 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5993 No 31026505 hsa_circ_000367 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_008421 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .128) were identified No 31261542 hsa_circ_004098 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6164 No 31026505 hsa_circ_002350 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6081 No 31026505 hsa_circ_006860 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6162 No 31026505 hsa_circ_002768 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6082 No 31026505 hsa_circ_000054 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6083 No 31026505 hsa_circ_000152 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6161 No 31026505 hsa_circ_004796 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6160 No 31026505 hsa_circ_001294 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6159 No 31026505 hsa_circ_007037 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6084 No 31026505 hsa_circ_006063 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6085 No 31026505 hsa_circ_005473 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6158 No 31026505 hsa_circ_005437 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6086 No 31026505 hsa_circ_003888 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6087 No 31026505 hsa_circ_000957 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6088 No 31026505 hsa_circ_002558 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6157 No 31026505 hsa_circ_0009043 CircRNA Homo sapiens Endometrial Neoplasms endometrial tissue Expression[lower expressed] qRT-PCR Data of circRNA sequencing showed a significant change in 75,928 unique circRNAs (P<0.05). The upregulated hsa_circ_0039569 and hsa_circ_0001610 and downregulated hsa_circ_0000437, hsa_circ_0001776, and hsa_circ_0009043 were validated by qRT-PCR analysis. Using bioinformatical methods, we found that hsa_circ_0039569 has the MRE of hsa-miR-542-3p and hsa-let-7c-5p. Hsa-miR-542-3p and hsa-let-7c-5p were downregulated in the grade 3 EC validated by qRT-PCR analysis. In the clinicopathological parameters, the expression level of hsa_circ_0039569 was significantly correlated with tumor differentiation (P=0.001). No 31308756 hsa_circ_005279 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6089 No 31026505 hsa_circ_005709 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6090 No 31026505 hsa_circ_0001776 CircRNA Homo sapiens Endometrial Neoplasms endometrial tissue Expression[lower expressed] qRT-PCR Data of circRNA sequencing showed a significant change in 75,928 unique circRNAs (P<0.05). The upregulated hsa_circ_0039569 and hsa_circ_0001610 and downregulated hsa_circ_0000437, hsa_circ_0001776, and hsa_circ_0009043 were validated by qRT-PCR analysis. Using bioinformatical methods, we found that hsa_circ_0039569 has the MRE of hsa-miR-542-3p and hsa-let-7c-5p. Hsa-miR-542-3p and hsa-let-7c-5p were downregulated in the grade 3 EC validated by qRT-PCR analysis. In the clinicopathological parameters, the expression level of hsa_circ_0039569 was significantly correlated with tumor differentiation (P=0.001). No 31308756 hsa_circ_004610 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6091 No 31026505 hsa_circ_0000437 CircRNA Homo sapiens Endometrial Neoplasms endometrial tissue Expression[lower expressed] qRT-PCR Data of circRNA sequencing showed a significant change in 75,928 unique circRNAs (P<0.05). The upregulated hsa_circ_0039569 and hsa_circ_0001610 and downregulated hsa_circ_0000437, hsa_circ_0001776, and hsa_circ_0009043 were validated by qRT-PCR analysis. Using bioinformatical methods, we found that hsa_circ_0039569 has the MRE of hsa-miR-542-3p and hsa-let-7c-5p. Hsa-miR-542-3p and hsa-let-7c-5p were downregulated in the grade 3 EC validated by qRT-PCR analysis. In the clinicopathological parameters, the expression level of hsa_circ_0039569 was significantly correlated with tumor differentiation (P=0.001). No 31308756 hsa_circ_000557 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6156 No 31026505 hsa_circ_0001610 CircRNA Homo sapiens Endometrial Neoplasms endometrial tissue Expression[highly expressed] qRT-PCR Data of circRNA sequencing showed a significant change in 75,928 unique circRNAs (P<0.05). The upregulated hsa_circ_0039569 and hsa_circ_0001610 and downregulated hsa_circ_0000437, hsa_circ_0001776, and hsa_circ_0009043 were validated by qRT-PCR analysis. Using bioinformatical methods, we found that hsa_circ_0039569 has the MRE of hsa-miR-542-3p and hsa-let-7c-5p. Hsa-miR-542-3p and hsa-let-7c-5p were downregulated in the grade 3 EC validated by qRT-PCR analysis. In the clinicopathological parameters, the expression level of hsa_circ_0039569 was significantly correlated with tumor differentiation (P=0.001). No 31308756 hsa_circ_000386 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6092 No 31026505 hsa_circ_002551 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6093 No 31026505 hsa_circ_0039569 CircRNA Homo sapiens Endometrial Neoplasms endometrial tissue Expression[highly expressed] qRT-PCR Data of circRNA sequencing showed a significant change in 75,928 unique circRNAs (P<0.05). The upregulated hsa_circ_0039569 and hsa_circ_0001610 and downregulated hsa_circ_0000437, hsa_circ_0001776, and hsa_circ_0009043 were validated by qRT-PCR analysis. Using bioinformatical methods, we found that hsa_circ_0039569 has the MRE of hsa-miR-542-3p and hsa-let-7c-5p. Hsa-miR-542-3p and hsa-let-7c-5p were downregulated in the grade 3 EC validated by qRT-PCR analysis. In the clinicopathological parameters, the expression level of hsa_circ_0039569 was significantly correlated with tumor differentiation (P=0.001). No 31308756 hsa_circ_005926 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6094 No 31026505 hsa_circ_000356 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6095 No 31026505 hsa_circ_001949 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6163 No 31026505 hsa_circ_006597 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6080 No 31026505 hsa_circ_006427 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5995 No 31026505 hsa_circ_000052 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6165 No 31026505 hsa_circ_4010-22 CircRNA Homo sapiens acute myocardial infarction blood Expression[highly expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009320. No 33063235 hsa_circ_001104 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6170 No 31026505 hsa_circ_007102 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6069 No 31026505 hsa_circ_0050908 CircRNA Homo sapiens acute myocardial infarction blood Expression[highly expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009319. No 33063235 hsa_circ_001103 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6070 No 31026505 hsa_circ_100933 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[lower expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_100562 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[lower expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_031282 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[lower expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_103091 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[lower expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_004000 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6169 No 31026505 hsa_circ_007075 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6168 No 31026505 hsa_circ_023983 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[lower expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_1011001 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[lower expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_035435 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[lower expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_001032 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6071 No 31026505 hsa_circ_000101 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6072 No 31026505 hsa_circ_006392 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6073 No 31026505 hsa_circ_006051 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6074 No 31026505 hsa_circ_007444 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[lower expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_004709 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6167 No 31026505 hsa_circ_007151 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6075 No 31026505 hsa_circ_004259 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6166 No 31026505 hsa_circ_101528 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[lower expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_002299 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6076 No 31026505 hsa_circ_006521 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6077 No 31026505 hsa_circ_006075 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6078 No 31026505 hsa_circ_000488 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6079 No 31026505 hsa_circ_000564 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6096 No 31026505 hsa_circ_005347 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6097 No 31026505 hsa_circ_003536 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6098 No 31026505 hsa_circ_001837 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6155 No 31026505 hsa_circ_006088 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6144 No 31026505 hsa_circ_005304 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6143 No 31026505 hsa_circ_001287 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6118 No 31026505 hsa_circ_004897 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6142 No 31026505 hsa_circ_006462 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6141 No 31026505 hsa_circ_003327 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6119 No 31026505 hsa_circ_001828 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6120 No 31026505 hsa_circ_002134 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6121 No 31026505 hsa_circ_006852 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6122 No 31026505 hsa_circ_003784 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6123 No 31026505 hsa_circ_001106 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6124 No 31026505 hsa_circ_001829 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6125 No 31026505 hsa_circ_000460 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6126 No 31026505 hsa_circ_004725 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6127 No 31026505 hsa_circ_003043 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6128 No 31026505 hsa_circ_004508 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6140 No 31026505 hsa_circ_002060 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6129 No 31026505 hsa_circ_000273 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6130 No 31026505 hsa_circ_001728 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6131 No 31026505 hsa_circ_006891 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6139 No 31026505 hsa_circ_003373 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6132 No 31026505 hsa_circ_004383 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6138 No 31026505 hsa_circ_003793 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6133 No 31026505 hsa_circ_006741 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1713 No 31026505 hsa_circ_005383 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6134 No 31026505 hsa_circ_005213 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6135 No 31026505 hsa_circ_000968 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6136 No 31026505 hsa_circ_000567 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6117 No 31026505 hsa_circ_006528 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6116 No 31026505 hsa_circ_006527 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6115 No 31026505 hsa_circ_001375 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6149 No 31026505 hsa_circ_006641 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6099 No 31026505 hsa_circ_001203 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6154 No 31026505 hsa_circ_001441 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6100 No 31026505 hsa_circ_007053 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6101 No 31026505 hsa_circ_001801 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6102 No 31026505 hsa_circ_000599 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6103 No 31026505 hsa_circ_002059 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6153 No 31026505 hsa_circ_001866 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6152 No 31026505 hsa_circ_003760 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6104 No 31026505 hsa_circ_002360 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6151 No 31026505 circMYC CircRNA Homo sapiens Melanoma melanoma tissue Interaction[c-MYC-SRSF] qRT-PCR//Luciferase Report Assay//RNA Pull-Down Our current study demonstrated that human circMYC was obviously upregulated in human melanoma tissue. No 31811601 hsa_circ_000022 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6150 No 31026505 hsa_circ_007068 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6148 No 31026505 hsa_circ_006529 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6114 No 31026505 hsa_circ_000977 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6105 No 31026505 hsa_circ_005905 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6106 No 31026505 hsa_circ_005729 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6107 No 31026505 hsa_circ_000086 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6147 No 31026505 hsa_circ_006168 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6108 No 31026505 hsa_circ_000671 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6109 No 31026505 hsa_circ_006045 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6110 No 31026505 hsa_circ_006000 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6111 No 31026505 hsa_circ_003204 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6112 No 31026505 hsa_circ_002046 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6113 No 31026505 hsa_circ_004551 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6146 No 31026505 hsa_circ_000088 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6145 No 31026505 hsa_circ_005870 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6068 No 31026505 hsa_circ_001736 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6067 No 31026505 hsa_circ_005253 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6066 No 31026505 hsa_circ_003488 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6029 No 31026505 hsa_circ_101202 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[highly expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_002798 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6183 No 31026505 hsa_circ_006778 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6014 No 31026505 hsa_circ_003775 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6182 No 31026505 hsa_circ_000649 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6015 No 31026505 hsa_circ_005627 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6016 No 31026505 hsa_circ_001098 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6017 No 31026505 hsa_circ_101341 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[highly expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_003596 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6181 No 31026505 hsa_circ_004247 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6018 No 31026505 hsa_circ_005216 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6019 No 31026505 hsa_circ_004353 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6020 No 31026505 hsa_circ_0009319 CircRNA Homo sapiens acute myocardial infarction blood Expression[lower expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009338. No 33063235 hsa_circ_0059665 CircRNA Homo sapiens acute myocardial infarction blood Expression[lower expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009337. No 33063235 hsa_circ_0122979 CircRNA Homo sapiens acute myocardial infarction blood Expression[lower expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009336. No 33063235 hsa_circ_006436 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6180 No 31026505 hsa_circ_004867 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6179 No 31026505 hsa_circ_000038 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6021 No 31026505 hsa_circ_005999 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6022 No 31026505 hsa_circ_4014-45 CircRNA Homo sapiens acute myocardial infarction blood Expression[lower expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009335. No 33063235 hsa_circ_0039155 CircRNA Homo sapiens acute myocardial infarction blood Expression[lower expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009334. No 33063235 hsa_circ_001593 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6023 No 31026505 hsa_circ_002352 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6024 No 31026505 hsa_circ_006911 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6025 No 31026505 hsa_circ_007009 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6026 No 31026505 hsa_circ_001257 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6027 No 31026505 hsa_circ_002376 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6028 No 31026505 hsa_circ_001513 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6013 No 31026505 hsa_circ_005384 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6184 No 31026505 hsa_circ_005220 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6012 No 31026505 hsa_circ_004896 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6007 No 31026505 hsa_circ_001071 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5996 No 31026505 hsa_circ_003199 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5997 No 31026505 hsa_circ_002121 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6188 No 31026505 hsa_circ_004559 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5998 No 31026505 hsa_circ_005277 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5999 No 31026505 hsa_circ_003683 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6000 No 31026505 hsa_circ_006553 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6001 No 31026505 hsa_circ_003294 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6002 No 31026505 hsa_circ_004350 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6003 No 31026505 hsa_circ_007207 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6004 No 31026505 hsa_circ_002138 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6005 No 31026505 hsa_circ_000450 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6006 No 31026505 hsa_circ_006974 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6008 No 31026505 hsa_circ_005600 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6011 No 31026505 hsa_circ_005455 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6187 No 31026505 hsa_circ_005616 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6186 No 31026505 hsa_circ_001400 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6009 No 31026505 hsa_circ_102459 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_0122984 CircRNA Homo sapiens acute myocardial infarction blood Expression[lower expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009340. No 33063235 hsa_circ_0081241 CircRNA Homo sapiens acute myocardial infarction blood Expression[lower expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009339. No 33063235 hsa_circ_001640 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_020068 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_001703 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6010 No 31026505 hsa_circ_004183 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_003067 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6185 No 31026505 hsa_circ_400850 CircRNA Homo sapiens Esophageal Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_005687 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6178 No 31026505 hsa_circ_006007 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6030 No 31026505 hsa_circ_005140 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6065 No 31026505 hsa_circ_006421 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6031 No 31026505 hsa_circ_1825-44 CircRNA Homo sapiens acute myocardial infarction blood Expression[highly expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009326. No 33063235 hsa_circ_007222 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6050 No 31026505 hsa_circ_002471 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6051 No 31026505 hsa_circ_004201 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6052 No 31026505 hsa_circ_004733 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6053 No 31026505 hsa_circ_007094 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6054 No 31026505 hsa_circ_004556 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6173 No 31026505 hsa_circ_001708 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6055 No 31026505 hsa_circ_002351 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6056 No 31026505 hsa_circ_006180 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6057 No 31026505 hsa_circ_103980 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[highly expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_0115392 CircRNA Homo sapiens acute myocardial infarction blood Expression[highly expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009325. No 33063235 hsa_circ_14702 CircRNA Homo sapiens acute myocardial infarction blood Expression[highly expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009324. No 33063235 hsa_circ_0060937 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[lower expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_4010-20 CircRNA Homo sapiens acute myocardial infarction blood Expression[highly expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009323. No 33063235 hsa_circ_000198 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6058 No 31026505 hsa_circ_006208 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6059 No 31026505 hsa_circ_003148 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6060 No 31026505 hsa_circ_005568 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6061 No 31026505 hsa_circ_006046 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6062 No 31026505 hsa_circ_005839 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6063 No 31026505 hsa_circ_005101 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6172 No 31026505 hsa_circ_101120 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[lower expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_0010551 CircRNA Homo sapiens acute myocardial infarction blood Expression[highly expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009322. No 33063235 hsa_circ_005418 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6171 No 31026505 hsa_circ_002043 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6064 No 31026505 hsa_circ_002995 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6049 No 31026505 hsa_circ_006779 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6048 No 31026505 hsa_circ_002234 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6047 No 31026505 hsa_circ_0095920 CircRNA Homo sapiens acute myocardial infarction blood Expression[lower expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009331. No 33063235 hsa_circ_003820 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6032 No 31026505 hsa_circ_004875 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6033 No 31026505 hsa_circ_006429 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6034 No 31026505 hsa_circ_000046 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6035 No 31026505 hsa_circ_101803 CircRNA Homo sapiens Carcinoma, Renal Cell renal tissue Expression[highly expressed] qRT-PCR//Microarray For the mentioned five up- and eleven down-regulated circRNAs, the circRNA IDs used in the databases ArrayStar and circBase are summarized in Table 2. No 31575051 hsa_circ_0113067 CircRNA Homo sapiens acute myocardial infarction blood Expression[lower expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009333. No 33063235 hsa_circ_003751 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6177 No 31026505 hsa_circ_002219 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6036 No 31026505 hsa_circ_004450 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6176 No 31026505 hsa_circ_005302 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6175 No 31026505 hsa_circ_004197 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6174 No 31026505 hsa_circ_0054211 CircRNA Homo sapiens acute myocardial infarction blood Expression[lower expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009330. No 33063235 hsa_circ_000916 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6046 No 31026505 hsa_circ_000448 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6037 No 31026505 hsa_circ_0066439 CircRNA Homo sapiens acute myocardial infarction blood Expression[lower expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009329. No 33063235 hsa_circ_000908 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6038 No 31026505 hsa_circ_005598 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6039 No 31026505 hsa_circ_003273 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6040 No 31026505 hsa_circ_0025097 CircRNA Homo sapiens acute myocardial infarction blood Expression[highly expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009328. No 33063235 hsa_circ_005748 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6041 No 31026505 hsa_circ_8493-7 CircRNA Homo sapiens acute myocardial infarction blood Expression[highly expressed] Microarray Compared with the control group, there were 650 differentially expressed circRNAs found in AMI patients (P < .05, fold change > 2), including 535 up-regulated circRNAs, such as hsa_circ_0050908, hsa_circRNA4010-22, hsa_circ_0081241, hsa_circ_0010551, hsa_circRNA4010-20, hsa_circRNA14702, hsa_circ_0115392, has_circRNA1825-44, has_circRNA8493-7, and hsa_circ_0025097. Furthermore, there were 115 down-regulated circRNAs, such as hsa_circ_0066439, hsa_circ_0054211, hsa_circ_0095920, hsa_circ_0122984, hsa_circ_0113067, hsa_circ_0039155, hsa_circRNA4014-45, hsa_circ_0122979, hsa_circ_0059665, and hsa_circ_0009327. No 33063235 hsa_circ_005287 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6042 No 31026505 hsa_circ_005463 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6043 No 31026505 hsa_circ_006235 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6044 No 31026505 hsa_circ_004043 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6045 No 31026505 hsa_circ_003650 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5886 No 31026505 hsa_circ_006170 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5885 No 31026505 hsa_circ_005536 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5884 No 31026505 hsa_circ_002399 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5742 No 31026505 hsa_circ_005577 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5743 No 31026505 hsa_circ_0007013 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC and para-carcinoma tissues Expression[Expression[lower expressed]-expression] qRT-PCR//Microarray The qRT-PCR assay showed the Expression[Expression[up-expression]-expression]regulation of miR-455-5p, miR-21-3p, miR-96-5p, miR-93-5p, RP11-973H7.5, and HOXC10 expression in LSCC as well as the Expression[down-expression]regulation of miR-486-5p, LINC00657, CTC-297N7.9, hsa_circ_0008832, hsa_circ_0033988, hsa_circ_0001445, hsa_circ_0007013, KRT4, HOPX, TGFBR2, and KDR expression in LSCC (Fig. 17). No 30128795 hsa_circ_003011 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5744 No 31026505 hsa_circ_000590 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6277 No 31026505 hsa_circ_007084 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5745 No 31026505 hsa_circ_005331 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5746 No 31026505 hsa_circ_003833 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5747 No 31026505 hsa_circ_000896 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5748 No 31026505 hsa_circ_000622 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6276 No 31026505 hsa_circ_004189 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5749 No 31026505 hsa_circ_006049 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5750 No 31026505 hsa_circ_002542 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5751 No 31026505 hsa_circ_006523 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5752 No 31026505 hsa_circ_004238 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5753 No 31026505 hsa_circ_002806 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5754 No 31026505 hsa_circ_005217 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5755 No 31026505 hsa_circ_001706 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5756 No 31026505 hsa_circ_102378 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .75) were identified No 31261542 hsa_circ_001058 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5757 No 31026505 hsa_circ_002085 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5758 No 31026505 hsa_circ_000344 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5759 No 31026505 hsa_circ_003452 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6275 No 31026505 hsa_circ_018255 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .74) were identified No 31261542 hsa_circ_000095 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5760 No 31026505 hsa_circ_000985 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5761 No 31026505 hsa_circ_006310 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5762 No 31026505 hsa_circ_006656 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5763 No 31026505 hsa_circ_103885 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .76) were identified No 31261542 hsa_circ_003790 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5741 No 31026505 hsa_circ_003143 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5883 No 31026505 hsa_circ_0001445 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC and para-carcinoma tissues Expression[Expression[lower expressed]-expression] qRT-PCR//Microarray The qRT-PCR assay showed the Expression[Expression[up-expression]-expression]regulation of miR-455-5p, miR-21-3p, miR-96-5p, miR-93-5p, RP11-973H7.5, and HOXC10 expression in LSCC as well as the Expression[down-expression]regulation of miR-486-5p, LINC00657, CTC-297N7.9, hsa_circ_0008832, hsa_circ_0033988, hsa_circ_0001445, hsa_circ_0007013, KRT4, HOPX, TGFBR2, and KDR expression in LSCC (Fig. 16). No 30128795 hsa_circ_006512 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5725 No 31026505 hsa_circ_005909 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5726 No 31026505 hsa_circ_002562 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5727 No 31026505 hsa_circ_002223 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5728 No 31026505 hsa_circ_001156 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5729 No 31026505 hsa_circ_001963 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5730 No 31026505 hsa_circ_005128 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5731 No 31026505 hsa_circ_102077 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .82) were identified No 31261542 hsa_circ_006769 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5732 No 31026505 hsa_circ_002460 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5733 No 31026505 hsa_circ_102076 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .81) were identified No 31261542 hsa_circ_001002 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .80) were identified No 31261542 hsa_circ_104690 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .79) were identified No 31261542 hsa_circ_005266 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6279 No 31026505 hsa_circ_003057 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .78) were identified No 31261542 circPSEN1 CircRNA Homo sapiens Alzheimer Disease ADAD patients Expression(highly expressed) RNA-seq Our findings show the differential expression of circPSEN1 is increased in ADAD. No 35246267 hsa_circ_000631 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6278 No 31026505 hsa_circ_102693 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .77) were identified No 31261542 hsa_circ_000938 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5734 No 31026505 hsa_circ_001757 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5735 No 31026505 hsa_circ_003042 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5736 No 31026505 hsa_circ_002731 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5737 No 31026505 hsa_circ_0008832 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC and para-carcinoma tissues Expression[Expression[lower expressed]-expression] qRT-PCR//Microarray The qRT-PCR assay showed the Expression[Expression[up-expression]-expression]regulation of miR-455-5p, miR-21-3p, miR-96-5p, miR-93-5p, RP11-973H7.5, and HOXC10 expression in LSCC as well as the Expression[down-expression]regulation of miR-486-5p, LINC00657, CTC-297N7.9, hsa_circ_0008832, hsa_circ_0033988, hsa_circ_0001445, hsa_circ_0007013, KRT4, HOPX, TGFBR2, and KDR expression in LSCC (Fig. 14). No 30128795 hsa_circ_005428 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5738 No 31026505 hsa_circ_0033988 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC and para-carcinoma tissues Expression[Expression[lower expressed]-expression] qRT-PCR//Microarray The qRT-PCR assay showed the Expression[Expression[up-expression]-expression]regulation of miR-455-5p, miR-21-3p, miR-96-5p, miR-93-5p, RP11-973H7.5, and HOXC10 expression in LSCC as well as the Expression[down-expression]regulation of miR-486-5p, LINC00657, CTC-297N7.9, hsa_circ_0008832, hsa_circ_0033988, hsa_circ_0001445, hsa_circ_0007013, KRT4, HOPX, TGFBR2, and KDR expression in LSCC (Fig. 15). No 30128795 hsa_circ_003590 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5739 No 31026505 hsa_circ_007050 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5740 No 31026505 hsa_circ_003968 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5764 No 31026505 hsa_circ_062160 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .73) were identified No 31261542 hsa_circ_104562 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .72) were identified No 31261542 hsa_circ_104212 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .71) were identified No 31261542 hsa_circ_005556 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5783 No 31026505 hsa_circ_004070 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5784 No 31026505 hsa_circ_000981 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5785 No 31026505 hsa_circ_0008675 CircRNA Homo sapiens Lupus Erythematosus, Systemic blood Expression[highly expressed] qRT-PCR Furthermore, the RT?qPCR results were consistent with the microarray data, in that all three selected circRNAs, hsa_circ_0082688, hsa_circ_0082689 and hsa_circ_0008675, were significantly upregulated in patients with SLE (P<0.05). No 33169172 hsa_circ_008544 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .68) were identified No 31261542 hsa_circ_004461 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5786 No 31026505 hsa_circ_000244 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5787 No 31026505 hsa_circ_002587 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5788 No 31026505 hsa_circ_003460 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5789 No 31026505 hsa_circ_000600 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6271 No 31026505 hsa_circ_001669 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5790 No 31026505 hsa_circ_003449 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5791 No 31026505 hsa_circ_004457 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5792 No 31026505 hsa_circ_0123996 CircRNA Homo sapiens Diabetes Mellitus, Type 2 kidney tissues regulation[miR-149-5p,Bach1 ] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay We observed that circ_0123996 expression was significantly increased in Type 2 diabetes (T2D) with DN in comparison to those patients without DN.Thus, it was revealed that circ_0123996 was involved in DN via sponging miR-149-5p and modulating Bach1 expression. No 32707301 hsa_circ_0071106 CircRNA Homo sapiens Diabetes Mellitus, Type 2 blood samples of 103 T2DM and 103 controls Interaction(hsa-miR-29a-5p) qPCR Lastly,we found that has_circ_0071106 increase the risk of T2DM (OR=2.819 (95% CI: 1.415~5.616)). Thearea under the ROCcurve has_circ_0071106 was 0.690, the sensitivity was 62.1%, and the specificity was 69.9%. The function prediction results showed that has_circ_0071106 was involved in biological processes such as protein binding, gene transcription, and may be involved in the pathway of hsa-miR-29a-5p regulating diabetes, has_circ_0071106 may be used as a diagnostic marker for T2DM. No 33967607 hsa_circ_0071336 CircRNA Homo sapiens Diabetes Mellitus, Type 2 blood in T2D Interaction(miR-93-5p/GLUT4 axis) qRT-PCR//Luciferase Report Assay//Western Blot The results showed that circulating hsa_circ_0071336 was significantly downregulated in blood in T2D and had a high diagnostic accuracy for discriminating T2D and impaired fasting glucose (IFG) from healthy controls. A luciferase reporter assay and western-blot analysis indicated that miR-93-5p was a direct target of hsa_circ_0071336, and miR-93-5p may negatively regulate the expression of GLUT4. The expression levels of hsa_circ_007136 were negatively related to miR-93-5p expression and positively correlated with the mRNA expression of GLUT4 in adipose tissues. Low expression of circ_0071336 was an independent predictor of T2D, IFG and insulin resistance. No 35439323 hsa_circ_004046 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5793 No 31026505 hsa_circ_001629 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5794 No 31026505 hsa_circ_006510 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5795 No 31026505 hsa_circ_0115355 CircRNA Homo sapiens Diabetes Mellitus, Type 2 patients with T2DM and INS-1 cell lines Interaction(miR-145/SIRT1 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//ELISA//Bioinformatics Analysis In this study, hsa_circ_0115355 was significantly underexpressed in both patients with T2DM and INS-1 cell lines. This study thus showed that hsa_circ_0115355 inhibits the occurrence and development of T2DM by regulating the expression of SIRT1 by adsorbing miR-145. No 35778952 hsa_circ_0004030 CircRNA Homo sapiens Prostatic Neoplasms cancer tissues Expression[highly expressed] qRT-PCR Three circRNAs, hsa_circ_0020050, hsa_circ_0004030, and hsa_circ_0123778 (circ-CTNNB2), were upregulated in the tissues of gastric cancer, prostate cancer, and colorectal cancer No 30563889 circKATNAL1 CircRNA Homo sapiens Prostatic Neoplasms Interaction[miR-145-3p/WISP1 pathway] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP Detection of circRNAs in PCa cells showed that circ_KATNAL1 is down-regulated, mainly located in the cytoplasm, and contains multiple binding sites of miR-145-3p, which is an anticancer miRNA. Circ_KATNAL1 and miR-145-3p promote each other's expression, and down-regulate the expression of the target gene WISP1. Both circ_KATNAL1 and miR-145-3p inhibit cell proliferation, invasiveness, and migration, down-regulate the expression of MMP-2 and MMP-9, promote cell apoptosis and the activation of caspase-3, caspase-8, caspase-9, and PARP, whereas WISP1 has the opposite effect, and the above-mentioned functions of circ_KATNAL1 were achieved through the miR-145-3p/WISP1 pathway. Therefore, circ_KATNAL1 plays an anticancer role in PCa cells through the miR-145-3p/WISP1 pathway, which could be an important target for the diagnosis and treatment of PCa. No 31800303 circITCH CircRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] qRT-PCR Circ-ITCH expression was decreased in tumor tissue compared with paired adjacent tissues (P< 0.001), and it presented with good value in distinguishing tumor tissues from paired adjacent tissues with area under curve (AUC) of 0.812 (95%CI: 0.780-0.845). Circ-ITCH low expression was associated with advanced pathologic T stage (P= 0.002) and high risk of lymph node metastasis (P= 0.047) in prostate cancer patients. As for prognosis, patients with circ-ITCH high expression had longer disease-free survival (DFS) (P< 0.001) and overall survival (OS) (P< 0.001). Additionally, circ-ITCH (high vs. low) independently predicted better survival, while Gleason score (> 7 vs. ⩽ 7) and surgical margin status (positive vs. negative) independently predicted worse survival in prostate patients underwent radical prostatectomy. No 31306101 hsa_circ_406683 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .67) were identified No 31261542 circAR3 CircRNA Homo sapiens Prostatic Neoplasms blood Regulated[up-regulated] qRT-PCR//Luciferase Report Assay . In PCa patient tissues, circAR3 is highly expressed in benign prostate and hormone naive PCa but downregulated when tumors were treated with neoadjuvant hormone therapy and further reduced when tumors progressed to the castrate-resistant stage. However, circAR3 levels in plasma are extremely low in patients with benign prostate, are upregulated in PCa patients with high Gleason scores and lymph node metastasis, and become undetectable in men after radical prostatectomy. circAR3 does not affect AR signaling, PCa cell proliferation, and invasion rates. Our results demonstrated that the origin of the detectable plasma circAR3 is from the prostate/PCa. Plasma circAR3 may be developed to be a PCa biomarker to monitor PCa development and tumor progression. No 31760376 hsa_circ_104077 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .66) were identified No 31261542 hsa_circ_102655 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .65) were identified No 31261542 hsa_circ_006775 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6272 No 31026505 hsa_circ_002881 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5782 No 31026505 hsa_circ_005036 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5781 No 31026505 hsa_circ_002617 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .69) were identified No 31261542 hsa_circ_003534 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5765 No 31026505 hsa_circ_101583 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .70) were identified No 31261542 hsa_circ_005143 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6274 No 31026505 hsa_circ_005952 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5766 No 31026505 hsa_circ_002453 CircRNA Homo sapiens Lupus Erythematosus, Systemic plasma Expression[highly expressed] qRT-PCR Plasma circRNA_002453 was also found to be upregulated in SLE patients when compared with RA patients and healthy controls. No 30172209 hsa_circ_001619 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5767 No 31026505 hsa_circ_006085 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5768 No 31026505 hsa_circ_006034 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5769 No 31026505 hsa_circ_002579 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5770 No 31026505 hsa_circ_003299 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5771 No 31026505 circPTPN22 CircRNA Homo sapiens Lupus Erythematosus, Systemic blood Expression[lower expressed] qRT-PCR : Bioinformatics analysis demonstrated that the parent gene of circPTPN22 was protein tyrosine phosphatase non-receptor type 22 (PTPN22), a potent regulator of T cell activation. The downregulation of circPTPN22 in patients with SLE was strongly negatively correlated with their Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores. No 30871426 hsa_circ_002159 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5772 No 31026505 hsa_circ_0000479 CircRNA Homo sapiens Lupus Erythematosus, Systemic peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR This enabled us to narrow down dysregulated circRNAs to 15 upregulated circRNAs. Only hsa_circ_0000479 was significantly upregulated in PBMCs of patients with SLE compared with HCs (P < 0.05). No 31608065 hsa_circ_004891 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5780 No 31026505 hsa_circ_004507 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5773 No 31026505 hsa_circ_000118 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6273 No 31026505 hsa_circ_001309 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5774 No 31026505 hsa_circ_002042 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5775 No 31026505 hsa_circ_0044235 CircRNA Homo sapiens Lupus Erythematosus, Systemic blood Expression[highly expressed] qRT-PCR Validation assays in 30 SLE patients and 20 HCs demonstrated that the levels of hsa_circ_0044235 and hsa_circ_0068367 were significantly decreased in the patients with SLE. No 31432107 hsa_circ_0068367 CircRNA Homo sapiens Lupus Erythematosus, Systemic blood Expression[highly expressed] qRT-PCR Validation assays in 30 SLE patients and 20 HCs demonstrated that the levels of hsa_circ_0044235 and hsa_circ_0068367 were significantly decreased in the patients with SLE. No 31432107 hsa_circ_002295 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5776 No 31026505 hsa_circ_000648 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5777 No 31026505 hsa_circ_0082688 CircRNA Homo sapiens Lupus Erythematosus, Systemic blood Expression[highly expressed] qRT-PCR Furthermore, the RT?qPCR results were consistent with the microarray data, in that all three selected circRNAs, hsa_circ_0082688, hsa_circ_0082689 and hsa_circ_0008675, were significantly upregulated in patients with SLE (P<0.05). No 33169172 hsa_circ_006389 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5778 No 31026505 hsa_circ_004997 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5779 No 31026505 hsa_circ_0082689 CircRNA Homo sapiens Lupus Erythematosus, Systemic blood Expression[highly expressed] qRT-PCR Furthermore, the RT?qPCR results were consistent with the microarray data, in that all three selected circRNAs, hsa_circ_0082688, hsa_circ_0082689 and hsa_circ_0008675, were significantly upregulated in patients with SLE (P<0.05). No 33169172 hsa_circ_006616 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6280 No 31026505 hsa_circ_004554 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6281 No 31026505 hsa_circ_000479 CircRNA Homo sapiens Alzheimer Disease tissues and cells Regulation qRT-PCR//Transfection//Luciferase Report Assay//Bioinformatics Analysis It is concluded that human circRNA_001481 and circRNA_000479 could be utilized as potential biomarkers for the early onset detection of AD and the development of effective therapeutics. No 35864990 hsa_circ_007221 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5688 No 31026505 hsa_circ_102369 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .109) were identified No 31261542 hsa_circ_001956 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5672 No 31026505 hsa_circ_103703 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .108) were identified No 31261542 hsa_circ_006952 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5673 No 31026505 hsa_circ_042437 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .107) were identified No 31261542 hsa_circ_003545 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .106) were identified No 31261542 hsa_circ_101210 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .105) were identified No 31261542 hsa_circ_003945 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5674 No 31026505 hsa_circ_005426 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5675 No 31026505 hsa_circ_002971 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .104) were identified No 31261542 hsa_circ_101379 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .103) were identified No 31261542 hsa_circ_004026 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5676 No 31026505 hsa_circ_004749 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6285 No 31026505 hsa_circ_104596 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .102) were identified No 31261542 hsa_circ_084010 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .101) were identified No 31261542 hsa_circ_004304 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5677 No 31026505 hsa_circ_001552 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5678 No 31026505 hsa_circ_002653 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5679 No 31026505 hsa_circ_001602 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5680 No 31026505 hsa_circ_007049 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5681 No 31026505 hsa_circ_006683 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5682 No 31026505 hsa_circ_002249 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5683 No 31026505 hsa_circ_007077 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6284 No 31026505 hsa_circ_405454 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .100) were identified No 31261542 hsa_circ_006820 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5684 No 31026505 hsa_circ_006284 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5685 No 31026505 hsa_circ_004111 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5686 No 31026505 hsa_circ_101997 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .110) were identified No 31261542 hsa_circ_000843 CircRNA Homo sapiens Alzheimer Disease blood Expression[highly expressed] qRT-PCR//Microarray We performed qRT-PCR to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015, suggesting that these two circRNAs were expressed at a low level or not expressed at all (Fig. 3). No 31834549 hsa_circ_102841 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .111) were identified No 31261542 hsa_circ_407013 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .119) were identified No 31261542 hsa_circ_030286 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .127) were identified No 31261542 hsa_circ_405163 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .126) were identified No 31261542 hsa_circ_003681 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5662 No 31026505 hsa_circ_052491 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .125) were identified No 31261542 hsa_circ_001742 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .124) were identified No 31261542 hsa_circ_060539 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .123) were identified No 31261542 hsa_circ_406926 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .122) were identified No 31261542 hsa_circ_101280 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .121) were identified No 31261542 hsa_circ_405619 CircRNA Homo sapiens Alzheimer Disease blood Expression[highly expressed] qRT-PCR//Microarray We performed qRT-PCR to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015, suggesting that these two circRNAs were expressed at a low level or not expressed at all (Fig. 3). No 31834549 hsa_circ_001612 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5663 No 31026505 hsa_circ_401106 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .120) were identified No 31261542 hsa_circ_007298 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5664 No 31026505 hsa_circ_104594 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .118) were identified No 31261542 hsa_circ_101211 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .112) were identified No 31261542 hsa_circ_001200 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5665 No 31026505 hsa_circ_002375 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .117) were identified No 31261542 hsa_circ_001417 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5666 No 31026505 hsa_circ_104100 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .116) were identified No 31261542 hsa_circ_101236 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .115) were identified No 31261542 hsa_circ_001532 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5667 No 31026505 hsa_circ_001022 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5668 No 31026505 hsa_circ_007056 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5669 No 31026505 hsa_circ_005612 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5670 No 31026505 hsa_circ_103702 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .114) were identified No 31261542 hsa_circ_000363 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5671 No 31026505 hsa_circ_401437 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .113) were identified No 31261542 hsa_circ_000178 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5687 No 31026505 hsa_circ_102597 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .99) were identified No 31261542 hsa_circ_001481 CircRNA Homo sapiens Alzheimer Disease tissues and cells Regulation qRT-PCR//Transfection//Luciferase Report Assay//Bioinformatics Analysis It is concluded that human circRNA_001481 and circRNA_000479 could be utilized as potential biomarkers for the early onset detection of AD and the development of effective therapeutics. No 35864990 hsa_circ_004617 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5689 No 31026505 hsa_circ_003577 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5710 No 31026505 hsa_circ_003066 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5711 No 31026505 hsa_circ_001885 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5712 No 31026505 hsa_circ_004943 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6283 No 31026505 hsa_circ_005121 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6282 No 31026505 hsa_circ_100512 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .90) were identified No 31261542 hsa_circ_103926 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .89) were identified No 31261542 hsa_circ_006030 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5713 No 31026505 hsa_circ_100465 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .88) were identified No 31261542 hsa_circ_000131 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5714 No 31026505 hsa_circ_101633 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .87) were identified No 31261542 hsa_circ_001613 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5715 No 31026505 hsa_circ_104742 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .86) were identified No 31261542 hsa_circ_103886 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .85) were identified No 31261542 hsa_circ_104076 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .84) were identified No 31261542 hsa_circ_403472 CircRNA Homo sapiens Alzheimer Disease blood Expression[lower expressed] qRT-PCR//Microarray We performed qRT-PCR to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015, suggesting that these two circRNAs were expressed at a low level or not expressed at all (Fig. 3). No 31834549 hsa_circ_0003391 CircRNA Homo sapiens Alzheimer Disease blood Expression[highly expressed] qRT-PCR In this study, we attempted to identify an aberrant circRNA, hsa_circ_0003391, which is significantly downregulated in the peripheral blood of patients with AD, and to explore the relationship between hsa_circ_0003391 and the clinical manifestation of AD. No 33424579 hsa_circ_001555 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5716 No 31026505 hsa_circ_001917 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5717 No 31026505 hsa_circ_003381 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5718 No 31026505 hsa_circ_006498 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5719 No 31026505 hsa_circ_004306 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5720 No 31026505 hsa_circ_002843 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5721 No 31026505 hsa_circ_000868 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5722 No 31026505 hsa_circ_000026 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5723 No 31026505 hsa_circ_007197 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5724 No 31026505 hsa_circ_406710 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .83) were identified No 31261542 hsa_circ_001306 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5709 No 31026505 hsa_circ_000318 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5708 No 31026505 hsa_circ_006551 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5707 No 31026505 hsa_circ_004776 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5696 No 31026505 hsa_circ_002728 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5690 No 31026505 hsa_circ_002245 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5691 No 31026505 hsa_circ_101524 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .98) were identified No 31261542 hsa_circ_101209 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .97) were identified No 31261542 hsa_circ_102598 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[lower expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .96) were identified No 31261542 hsa_circ_403230 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .95) were identified No 31261542 hsa_circ_001206 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .94) were identified No 31261542 hsa_circ_007204 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5692 No 31026505 hsa_circ_104395 CircRNA Homo sapiens Alzheimer Disease blood Expression[lower expressed] qRT-PCR//Microarray We performed qRT-PCR to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015, suggesting that these two circRNAs were expressed at a low level or not expressed at all (Fig. 3). No 31834549 hsa_circ_005075 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5693 No 31026505 hsa_circ_001363 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5694 No 31026505 hsa_circ_003791 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5695 No 31026505 hsa_circ_002211 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5697 No 31026505 hsa_circ_006499 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5706 No 31026505 hsa_circ_102624 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .93) were identified No 31261542 hsa_circ_006907 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5698 No 31026505 hsa_circ_104214 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .92) were identified No 31261542 hsa_circ_006015 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5699 No 31026505 hsa_circ_007010 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5700 No 31026505 hsa_circ_003064 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5701 No 31026505 hsa_circ_002156 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5702 No 31026505 hsa_circ_008036 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .91) were identified No 31261542 hsa_circ_402904 CircRNA Homo sapiens Alzheimer Disease blood Expression[lower expressed] qRT-PCR//Microarray We performed qRT-PCR to validate the microarray data of 10 randomly selected differentially expressed circRNAs, including five upregulated circRNAs (hsa_circRNA_103366, hsa_circRNA_103936, hsa_circRNA_101618, hsa_circRNA_405619, and hsa_circRNA_000843) and five downregulated circRNAs (hsa_circRNA_104395, hsa_circRNA_400066, hsa_circRNA_010015, hsa_circRNA_402904, and hsa_circRNA_403472). We verified eight circRNAs, but were unable to detect hsa_circRNA_400066 and hsa_circRNA_010015, suggesting that these two circRNAs were expressed at a low level or not expressed at all (Fig. 3). No 31834549 hsa_circ_004515 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5703 No 31026505 hsa_circ_002251 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5704 No 31026505 hsa_circ_006259 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5705 No 31026505 hsa_circ_100938 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .64) were identified No 31261542 hsa_circ_006751 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6270 No 31026505 hsa_circ_405040 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .63) were identified No 31261542 hsa_circ_001909 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6235 No 31026505 hsa_circ_006829 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5838 No 31026505 hsa_circ_0057213 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 38. No 32509077 hsa_circ_0057224 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 39. No 32509077 hsa_circ_0057222 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 40. No 32509077 hsa_circ_005801 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5839 No 31026505 hsa_circ_103730 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .24) were identified No 31261542 hsa_circ_103527 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .23) were identified No 31261542 hsa_circ_000205 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5840 No 31026505 hsa_circ_006649 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5841 No 31026505 hsa_circ_004748 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5842 No 31026505 hsa_circ_0016064 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 41. No 32509077 hsa_circ_102328 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .22) were identified No 31261542 hsa_circ_405031 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .21) were identified No 31261542 hsa_circ_006287 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5843 No 31026505 hsa_circ_102330 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .20) were identified No 31261542 hsa_circ_100544 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .19) were identified No 31261542 hsa_circ_100540 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .18) were identified No 31261542 hsa_circ_006206 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5844 No 31026505 hsa_circ_005295 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5845 No 31026505 hsa_circ_005284 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5846 No 31026505 hsa_circ_006928 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5847 No 31026505 hsa_circ_004478 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5848 No 31026505 hsa_circ_000725 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5849 No 31026505 hsa_circ_102876 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .17) were identified No 31261542 hsa_circ_100543 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .16) were identified No 31261542 hsa_circ_000976 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5850 No 31026505 hsa_circ_103526 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .15) were identified No 31261542 hsa_circ_0057223 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 37. No 32509077 hsa_circ_004444 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5837 No 31026505 hsa_circ_0067804 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 36. No 32509077 hsa_circ_101274 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .28) were identified No 31261542 hsa_circ_100542 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .31) were identified No 31261542 hsa_circ_087236 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .30) were identified No 31261542 hsa_circ_0020060 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 28. No 32509077 hsa_circ_0074026 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 29. No 32509077 hsa_circ_004174 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6238 No 31026505 hsa_circ_0032812 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 30. No 32509077 hsa_circ_0087142 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 31. No 32509077 hsa_circ_005579 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5828 No 31026505 hsa_circ_006668 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6237 No 31026505 hsa_circ_0087140 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 32. No 32509077 hsa_circ_000389 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5829 No 31026505 hsa_circ_405266 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .29) were identified No 31261542 hsa_circ_000133 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5830 No 31026505 hsa_circ_0067802 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 35. No 32509077 hsa_circ_005674 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5831 No 31026505 hsa_circ_002686 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5832 No 31026505 hsa_circ_001862 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5833 No 31026505 hsa_circ_005558 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5834 No 31026505 hsa_circ_0087144 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 33. No 32509077 hsa_circ_003809 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5835 No 31026505 hsa_circ_004640 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6236 No 31026505 hsa_circ_004080 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5836 No 31026505 hsa_circ_085302 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .27) were identified No 31261542 hsa_circ_403267 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .26) were identified No 31261542 hsa_circ_101273 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .25) were identified No 31261542 hsa_circ_0007499 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 34. No 32509077 hsa_circ_005308 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5851 No 31026505 hsa_circ_001550 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6234 No 31026505 hsa_circ_001364 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6240 No 31026505 hsa_circ_001984 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5852 No 31026505 hsa_circ_101271 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .06) were identified No 31261542 hsa_circ_000289 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6227 No 31026505 hsa_circ_005981 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5869 No 31026505 hsa_circ_405761 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .05) were identified No 31261542 hsa_circ_003845 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5870 No 31026505 hsa_circ_006089 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5871 No 31026505 hsa_circ_006044 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6226 No 31026505 hsa_circ_005105 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5872 No 31026505 hsa_circ_004727 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5873 No 31026505 hsa_circ_005611 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5874 No 31026505 hsa_circ_001918 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6225 No 31026505 hsa_circ_005099 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5875 No 31026505 hsa_circ_000329 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5876 No 31026505 hsa_circ_0006410 CircRNA Homo sapiens Prostatic Neoplasms two pairs of PCa tissues and adjacent tissues Regulation qRT-PCR Thus, we utilized high-throughput sequencing data and bioinformatics analysis to identify specifically expressed circRNAs in PCa and filtered out five specific circRNAs for further analysis-hsa_circ_0006410, hsa_circ_0003970, hsa_circ_0006754, hsa_circ_0005848, and a novel circRNA, hsa_circ_AKAP7. No 33574834 hsa_circ_0003970 CircRNA Homo sapiens Prostatic Neoplasms two pairs of PCa tissues and adjacent tissues Regulation qRT-PCR Thus, we utilized high-throughput sequencing data and bioinformatics analysis to identify specifically expressed circRNAs in PCa and filtered out five specific circRNAs for further analysis-hsa_circ_0006410, hsa_circ_0003970, hsa_circ_0006754, hsa_circ_0005848, and a novel circRNA, hsa_circ_AKAP7. No 33574834 hsa_circ_007282 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6224 No 31026505 hsa_circ_006706 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6223 No 31026505 hsa_circ_0006754 CircRNA Homo sapiens Prostatic Neoplasms two pairs of PCa tissues and adjacent tissues Regulation qRT-PCR Thus, we utilized high-throughput sequencing data and bioinformatics analysis to identify specifically expressed circRNAs in PCa and filtered out five specific circRNAs for further analysis-hsa_circ_0006410, hsa_circ_0003970, hsa_circ_0006754, hsa_circ_0005848, and a novel circRNA, hsa_circ_AKAP7. No 33574834 hsa_circ_003219 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5877 No 31026505 hsa_circ_001292 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5878 No 31026505 hsa_circ_004384 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5879 No 31026505 hsa_circ_0005848 CircRNA Homo sapiens Prostatic Neoplasms two pairs of PCa tissues and adjacent tissues Regulation qRT-PCR Thus, we utilized high-throughput sequencing data and bioinformatics analysis to identify specifically expressed circRNAs in PCa and filtered out five specific circRNAs for further analysis-hsa_circ_0006410, hsa_circ_0003970, hsa_circ_0006754, hsa_circ_0005848, and a novel circRNA, hsa_circ_AKAP7. No 33574834 hsa_circ_AKAP7 CircRNA Homo sapiens Prostatic Neoplasms two pairs of PCa tissues and adjacent tissues Regulation qRT-PCR Thus, we utilized high-throughput sequencing data and bioinformatics analysis to identify specifically expressed circRNAs in PCa and filtered out five specific circRNAs for further analysis-hsa_circ_0006410, hsa_circ_0003970, hsa_circ_0006754, hsa_circ_0005848, and a novel circRNA, hsa_circ_AKAP7. No 33574834 hsa_circ_0001747 CircRNA Homo sapiens Prostatic Neoplasms 25 pairs of PCa and adjacent normal tissue samples Regulation In Vivo Experiment//Western Blot//qRT-PCR//Microarray//IHC the hsa_circ_0001747 signature was selected for further experimental verification in vitro and in vivo, which showed that downregulated hsa_circ_0001747 might facilitate PCa via augmenting autophagy. No 34294687 hsa_circ_000864 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5880 No 31026505 hsa_circ_005225 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5881 No 31026505 hsa_circ_000485 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5882 No 31026505 hsa_circ_102329 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .07) were identified No 31261542 hsa_circ_003741 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5868 No 31026505 hsa_circ_004889 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5867 No 31026505 hsa_circ_002403 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .09) were identified No 31261542 hsa_circ_062161 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .14) were identified No 31261542 hsa_circ_103525 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .13) were identified No 31261542 hsa_circ_000447 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6233 No 31026505 hsa_circ_003352 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5853 No 31026505 hsa_circ_006305 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5854 No 31026505 hsa_circ_003771 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6232 No 31026505 hsa_circ_004881 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6231 No 31026505 hsa_circ_002450 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6230 No 31026505 hsa_circ_000992 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .12) were identified No 31261542 hsa_circ_047274 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .11) were identified No 31261542 hsa_circ_009084 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .10) were identified No 31261542 hsa_circ_005208 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6229 No 31026505 hsa_circ_001568 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5855 No 31026505 hsa_circ_001534 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5866 No 31026505 hsa_circ_000734 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6228 No 31026505 hsa_circ_004034 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5856 No 31026505 hsa_circ_030389 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .08) were identified No 31261542 hsa_circ_003480 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5857 No 31026505 hsa_circ_003027 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5858 No 31026505 hsa_circ_005613 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5859 No 31026505 hsa_circ_002379 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5860 No 31026505 hsa_circ_004160 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5861 No 31026505 hsa_circ_000262 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5862 No 31026505 hsa_circ_000319 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5863 No 31026505 hsa_circ_006410 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5864 No 31026505 hsa_circ_000478 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5865 No 31026505 hsa_circ_007258 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6239 No 31026505 hsa_circ_004445 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6241 No 31026505 hsa_circ_006230 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5796 No 31026505 hsa_circ_001683 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5820 No 31026505 hsa_circ_002989 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6258 No 31026505 hsa_circ_104131 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .52) were identified No 31261542 hsa_circ_003671 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .51) were identified No 31261542 hsa_circ_105028 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .50) were identified No 31261542 hsa_circ_005646 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6257 No 31026505 hsa_circ_004509 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6256 No 31026505 hsa_circ_004308 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5804 No 31026505 hsa_circ_003091 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5805 No 31026505 hsa_circ_006258 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5806 No 31026505 hsa_circ_003271 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5807 No 31026505 hsa_circ_003263 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5808 No 31026505 hsa_circ_000998 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5809 No 31026505 hsa_circ_000814 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5810 No 31026505 hsa_circ_000994 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5811 No 31026505 circZNF609 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Expression[highly expressed] Flow Cytometry//qRT-PCR//RIP//MTT//Colony Formation Assay//Transwell Assay Circ-ZNF609 was abnormally up-regulated in PCa tissues and cell lines. No 32943916 hsa_circ_404781 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .49) were identified No 31261542 hsa_circ_000362 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5812 No 31026505 hsa_circ_003521 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5813 No 31026505 hsa_circ_001233 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5814 No 31026505 hsa_circ_004249 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5815 No 31026505 hsa_circ_007323 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5816 No 31026505 hsa_circ_006202 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5817 No 31026505 hsa_circ_001512 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5818 No 31026505 hsa_circ_100148 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .48) were identified No 31261542 hsa_circ_006501 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5819 No 31026505 hsa_circ_000451 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6255 No 31026505 hsa_circ_007011 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6254 No 31026505 hsa_circ_004609 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5803 No 31026505 hsa_circ_006689 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6259 No 31026505 hsa_circ_103518 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .53) were identified No 31261542 hsa_circ_103432 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .59) were identified No 31261542 hsa_circ_001242 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5797 No 31026505 hsa_circ_102718 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .62) were identified No 31261542 hsa_circ_104689 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .61) were identified No 31261542 hsa_circ_0001633 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues Expression[lower expressed] qRT-PCR//Microarray Three circRNAs, hsa_circ_0001206, hsa_circ_0001633, and hsa_circ_0009061 were validated to be down-regulated in PCa by quantitative real-time PCR (qRT-PCR) and hsa_circ_0001206 as well as hsa_circ_0009061 was significantly associated with clinical features of PCa patients. No 31198063 hsa_circ_0009061 CircRNA Homo sapiens Prostatic Neoplasms PCa tissues Expression[lower expressed] qRT-PCR//Microarray Three circRNAs, hsa_circ_0001206, hsa_circ_0001633, and hsa_circ_0009061 were validated to be down-regulated in PCa by quantitative real-time PCR (qRT-PCR) and hsa_circ_0001206 as well as hsa_circ_0009061 was significantly associated with clinical features of PCa patients. No 31198063 hsa_circ_005264 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6269 No 31026505 hsa_circ_006479 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .60) were identified No 31261542 hsa_circ_006602 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5798 No 31026505 hsa_circ_000103 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6268 No 31026505 hsa_circ_007114 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5799 No 31026505 hsa_circ_005978 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6267 No 31026505 hsa_circ_006494 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5800 No 31026505 hsa_circ_100091 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .58) were identified No 31261542 hsa_circ_002639 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6260 No 31026505 hsa_circ_005565 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5801 No 31026505 hsa_circ_000549 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6266 No 31026505 hsa_circ_005435 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6265 No 31026505 hsa_circ_000933 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6264 No 31026505 hsa_circ_005946 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5802 No 31026505 hsa_circ_007312 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6263 No 31026505 hsa_circ_076967 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .57) were identified No 31261542 hsa_circ_005172 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6262 No 31026505 hsa_circ_002487 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .56) were identified No 31261542 hsa_circ_104777 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .55) were identified No 31261542 hsa_circ_002640 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6261 No 31026505 hsa_circ_402193 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .54) were identified No 31261542 hsa_circ_402777 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .47) were identified No 31261542 hsa_circ_0033074 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 2. No 32509077 hsa_circ_002852 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5827 No 31026505 hsa_circ_002520 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6253 No 31026505 hsa_circ_0040578 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 13. No 32509077 hsa_circ_104064 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .33) were identified No 31261542 hsa_circ_000924 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5824 No 31026505 hsa_circ_0070475 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 14. No 32509077 hsa_circ_0005917 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 15. No 32509077 hsa_circ_0070466 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 16. No 32509077 hsa_circ_001155 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5825 No 31026505 hsa_circ_006349 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6248 No 31026505 hsa_circ_001836 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6247 No 31026505 hsa_circ_005763 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6246 No 31026505 hsa_circ_000730 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6245 No 31026505 hsa_circ_0013059 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 17. No 32509077 hsa_circ_0062625 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 18. No 32509077 hsa_circ_0075601 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 19. No 32509077 hsa_circ_0004646 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 20. No 32509077 hsa_circ_0072904 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 21. No 32509077 hsa_circ_0020064 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 22. No 32509077 hsa_circ_0090179 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 23. No 32509077 hsa_circ_104132 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .32) were identified No 31261542 hsa_circ_0090180 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 24. No 32509077 hsa_circ_000475 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5826 No 31026505 hsa_circ_002422 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6244 No 31026505 hsa_circ_002772 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6243 No 31026505 hsa_circ_0057896 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 25. No 32509077 hsa_circ_0029996 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 26. No 32509077 hsa_circ_003605 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6242 No 31026505 hsa_circ_0032813 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[lower expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 27. No 32509077 hsa_circ_100539 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .34) were identified No 31261542 hsa_circ_005389 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5823 No 31026505 hsa_circ_103267 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .35) were identified No 31261542 hsa_circ_0040583 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 7. No 32509077 hsa_circ_004601 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .46) were identified No 31261542 hsa_circ_003636 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .45) were identified No 31261542 hsa_circ_0057549 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 3. No 32509077 hsa_circ_001471 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6252 No 31026505 hsa_circ_0076303 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 4. No 32509077 hsa_circ_102904 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .44) were identified No 31261542 hsa_circ_007069 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6251 No 31026505 hsa_circ_400998 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .43) were identified No 31261542 hsa_circ_0076304 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 5. No 32509077 hsa_circ_005191 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5821 No 31026505 hsa_circ_020496 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .42) were identified No 31261542 hsa_circ_0076305 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 6. No 32509077 hsa_circ_0024925 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 8. No 32509077 hsa_circ_104130 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .36) were identified No 31261542 hsa_circ_101112 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .41) were identified No 31261542 hsa_circ_005690 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5822 No 31026505 hsa_circ_005738 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6250 No 31026505 hsa_circ_002797 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .40) were identified No 31261542 hsa_circ_0008053 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 9. No 32509077 hsa_circ_100937 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .39) were identified No 31261542 hsa_circ_104228 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .38) were identified No 31261542 hsa_circ_0007405 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 10. No 32509077 hsa_circ_006582 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6249 No 31026505 hsa_circ_0062627 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 11. No 32509077 hsa_circ_0004390 CircRNA Homo sapiens Prostatic Neoplasms PCA tissues Expression[highly expressed] Microarray Hierarchical clustering (Figure 1A), volcano plot (Figure 1B), and scatter plots (Figure 1C) showed that the different expression profiles of circRNAs between PCA and non-PCA tissues were diverse. The top each twenty up- and down-regulated circRNAs are listed in Table 12. No 32509077 hsa_circ_101042 CircRNA Homo sapiens Pituitary Neoplasms invasive and non-invasive NFPA tumor tissues Expression[highly expressed] qRT-PCR//RNA-seq//Microarray And significantly aberrantly expressed circRNAs between the 2 groups were illustrated in the volcano plot (Fig. ​(Fig.1C).1C). Overall, 152 dysregulated circRNAs (fold change ≥ 2.0, P < .37) were identified No 31261542 hsa_circ_004462 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5155 No 31026505 hsa_circ_006964 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6415 No 31026505 hsa_circ_004999 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5154 No 31026505 hsa_circ_002883 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4376 No 31026505 hsa_circ_006749 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4378 No 31026505 hsa_circ_0081375 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_0073792 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_0023309 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_005787 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6790 No 31026505 hsa_circ_006838 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4379 No 31026505 hsa_circ_006095 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4380 No 31026505 hsa_circ_006376 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4381 No 31026505 hsa_circ_0003570 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_000175 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6789 No 31026505 hsa_circ_006035 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4382 No 31026505 hsa_circ_005404 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6788 No 31026505 hsa_circ_0023310 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_002621 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6787 No 31026505 hsa_circ_0073782 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_0045305 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_002648 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4383 No 31026505 hsa_circ_002550 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4384 No 31026505 hsa_circ_0028687 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_002267 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4385 No 31026505 hsa_circ_001346 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4386 No 31026505 hsa_circ_002388 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4387 No 31026505 hsa_circ_0028694 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_006840 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4388 No 31026505 hsa_circ_0028697 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_0023311 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_005120 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4389 No 31026505 hsa_circ_005453 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4377 No 31026505 hsa_circ_000127 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6791 No 31026505 hsa_circ_001896 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6762 No 31026505 hsa_circ_005658 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4375 No 31026505 hsa_circ_003165 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6805 No 31026505 hsa_circ_003899 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4367 No 31026505 hsa_circ_003211 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6804 No 31026505 hsa_circ_005095 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6803 No 31026505 hsa_circ_005276 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6802 No 31026505 hsa_circ_0006751 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_000696 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6801 No 31026505 hsa_circ_002236 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4368 No 31026505 hsa_circ_004242 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6800 No 31026505 hsa_circ_005921 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6799 No 31026505 hsa_circ_005962 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6798 No 31026505 hsa_circ_004162 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6797 No 31026505 hsa_circ_001971 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6796 No 31026505 hsa_circ_001395 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6795 No 31026505 hsa_circ_0037141 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_000714 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4369 No 31026505 hsa_circ_0035024 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_0025368 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_000025 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4370 No 31026505 hsa_circ_005669 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4371 No 31026505 hsa_circ_0037139 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_000092 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4372 No 31026505 hsa_circ_004008 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6794 No 31026505 hsa_circ_005865 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4373 No 31026505 hsa_circ_005605 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6793 No 31026505 hsa_circ_003841 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6792 No 31026505 hsa_circ_005597 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4374 No 31026505 hsa_circ_002160 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4390 No 31026505 hsa_circ_0016779 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_0016780 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_0069236 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_005083 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6772 No 31026505 hsa_circ_002367 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4400 No 31026505 hsa_circ_005967 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4401 No 31026505 hsa_circ_001351 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6771 No 31026505 hsa_circ_001606 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6770 No 31026505 hsa_circ_002432 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4402 No 31026505 hsa_circ_001966 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6769 No 31026505 circFAM120B CircRNA Homo sapiens Aortic Dissection aortic tissues Expression[lower expressed] qRT-PCR//RNA-seq//Western Blot The top 10 significantly differentially expressed circRNAs, 10 significantly differentially expressed miRs and 10 significantly differentially expressed mRNAs identified in the RNA-Seq analysis were selected for further qRT-PCR analysis. Thirty matched human AAAD and normal aortic tissues were used in this part, the results of qRT-PCR confirmed the up-regulation of circUBA2, circARHGAP26, circCHSY1, circMBNL1, circIQGAP1, circMED13, circMYH10, circRAB7A, hsa-miR-210-5p, hsa-miR-4521, hsa-miR-128-3p, hsa-miR-1180-5p, EPG5, ITGA2B, TANC2, FGR, IL-1α and TEAD2 and the down-regulation of circCEP70, circFAM120B, hsa-miR-622, hsa-miR-6773-5p, hsa-miR-8071, hsa-miR-139-3p, hsa-miR-187-3p, hsa-miR-1273-3p, FGD5, FOXF1,CDH5 and KCNK5 (Figs 2A–2T and S1). No 31251793 circCEP70 CircRNA Homo sapiens Aortic Dissection aortic tissues Expression[lower expressed] qRT-PCR//RNA-seq//Western Blot The top 10 significantly differentially expressed circRNAs, 10 significantly differentially expressed miRs and 10 significantly differentially expressed mRNAs identified in the RNA-Seq analysis were selected for further qRT-PCR analysis. Thirty matched human AAAD and normal aortic tissues were used in this part, the results of qRT-PCR confirmed the up-regulation of circUBA2, circARHGAP26, circCHSY1, circMBNL1, circIQGAP1, circMED13, circMYH10, circRAB7A, hsa-miR-210-5p, hsa-miR-4521, hsa-miR-128-3p, hsa-miR-1180-5p, EPG5, ITGA2B, TANC2, FGR, IL-1α and TEAD2 and the down-regulation of circCEP70, circFAM120B, hsa-miR-622, hsa-miR-6773-5p, hsa-miR-8071, hsa-miR-139-3p, hsa-miR-187-3p, hsa-miR-1273-3p, FGD5, FOXF1,CDH5 and KCNK5 (Figs 2A–2T and S1). No 31251793 hsa_circ_001210 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4403 No 31026505 circRAB7A CircRNA Homo sapiens Aortic Dissection aortic tissues Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot The top 10 significantly differentially expressed circRNAs, 10 significantly differentially expressed miRs and 10 significantly differentially expressed mRNAs identified in the RNA-Seq analysis were selected for further qRT-PCR analysis. Thirty matched human AAAD and normal aortic tissues were used in this part, the results of qRT-PCR confirmed the up-regulation of circUBA2, circARHGAP26, circCHSY1, circMBNL1, circIQGAP1, circMED13, circMYH10, circRAB7A, hsa-miR-210-5p, hsa-miR-4521, hsa-miR-128-3p, hsa-miR-1180-5p, EPG5, ITGA2B, TANC2, FGR, IL-1α and TEAD2 and the down-regulation of circCEP70, circFAM120B, hsa-miR-622, hsa-miR-6773-5p, hsa-miR-8071, hsa-miR-139-3p, hsa-miR-187-3p, hsa-miR-1273-3p, FGD5, FOXF1,CDH5 and KCNK5 (Figs 2A–2T and S1). No 31251793 circMYH10 CircRNA Homo sapiens Aortic Dissection aortic tissues Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot The top 10 significantly differentially expressed circRNAs, 10 significantly differentially expressed miRs and 10 significantly differentially expressed mRNAs identified in the RNA-Seq analysis were selected for further qRT-PCR analysis. Thirty matched human AAAD and normal aortic tissues were used in this part, the results of qRT-PCR confirmed the up-regulation of circUBA2, circARHGAP26, circCHSY1, circMBNL1, circIQGAP1, circMED13, circMYH10, circRAB7A, hsa-miR-210-5p, hsa-miR-4521, hsa-miR-128-3p, hsa-miR-1180-5p, EPG5, ITGA2B, TANC2, FGR, IL-1α and TEAD2 and the down-regulation of circCEP70, circFAM120B, hsa-miR-622, hsa-miR-6773-5p, hsa-miR-8071, hsa-miR-139-3p, hsa-miR-187-3p, hsa-miR-1273-3p, FGD5, FOXF1,CDH5 and KCNK5 (Figs 2A–2T and S1). No 31251793 circMED13 CircRNA Homo sapiens Aortic Dissection aortic tissues Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot The top 10 significantly differentially expressed circRNAs, 10 significantly differentially expressed miRs and 10 significantly differentially expressed mRNAs identified in the RNA-Seq analysis were selected for further qRT-PCR analysis. Thirty matched human AAAD and normal aortic tissues were used in this part, the results of qRT-PCR confirmed the up-regulation of circUBA2, circARHGAP26, circCHSY1, circMBNL1, circIQGAP1, circMED13, circMYH10, circRAB7A, hsa-miR-210-5p, hsa-miR-4521, hsa-miR-128-3p, hsa-miR-1180-5p, EPG5, ITGA2B, TANC2, FGR, IL-1α and TEAD2 and the down-regulation of circCEP70, circFAM120B, hsa-miR-622, hsa-miR-6773-5p, hsa-miR-8071, hsa-miR-139-3p, hsa-miR-187-3p, hsa-miR-1273-3p, FGD5, FOXF1,CDH5 and KCNK5 (Figs 2A–2T and S1). No 31251793 hsa_circ_003412 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6768 No 31026505 hsa_circ_005103 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4404 No 31026505 hsa_circ_000197 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6767 No 31026505 hsa_circ_003056 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4405 No 31026505 hsa_circ_001670 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6766 No 31026505 hsa_circ_006976 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4406 No 31026505 hsa_circ_004583 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4407 No 31026505 hsa_circ_006975 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4408 No 31026505 hsa_circ_006444 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6765 No 31026505 circIQGAP1 CircRNA Homo sapiens Aortic Dissection aortic tissues Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot The top 10 significantly differentially expressed circRNAs, 10 significantly differentially expressed miRs and 10 significantly differentially expressed mRNAs identified in the RNA-Seq analysis were selected for further qRT-PCR analysis. Thirty matched human AAAD and normal aortic tissues were used in this part, the results of qRT-PCR confirmed the up-regulation of circUBA2, circARHGAP26, circCHSY1, circMBNL1, circIQGAP1, circMED13, circMYH10, circRAB7A, hsa-miR-210-5p, hsa-miR-4521, hsa-miR-128-3p, hsa-miR-1180-5p, EPG5, ITGA2B, TANC2, FGR, IL-1α and TEAD2 and the down-regulation of circCEP70, circFAM120B, hsa-miR-622, hsa-miR-6773-5p, hsa-miR-8071, hsa-miR-139-3p, hsa-miR-187-3p, hsa-miR-1273-3p, FGD5, FOXF1,CDH5 and KCNK5 (Figs 2A–2T and S1). No 31251793 hsa_circ_001743 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4409 No 31026505 hsa_circ_004127 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4410 No 31026505 hsa_circ_003169 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6764 No 31026505 hsa_circ_006257 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4411 No 31026505 hsa_circ_005901 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4399 No 31026505 hsa_circ_002615 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4398 No 31026505 hsa_circ_001280 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4397 No 31026505 hsa_circ_001859 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6782 No 31026505 hsa_circ_0016778 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_0016773 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_0016776 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_001876 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6786 No 31026505 hsa_circ_003538 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6785 No 31026505 hsa_circ_006558 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4391 No 31026505 hsa_circ_005886 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4392 No 31026505 hsa_circ_004791 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4393 No 31026505 hsa_circ_000432 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6784 No 31026505 hsa_circ_005136 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6783 No 31026505 hsa_circ_0016775 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_004352 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4394 No 31026505 hsa_circ_004537 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6781 No 31026505 hsa_circ_006084 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6773 No 31026505 hsa_circ_0016774 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_0016772 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_006420 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6780 No 31026505 hsa_circ_006534 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6779 No 31026505 hsa_circ_0065978 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_005835 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6778 No 31026505 hsa_circ_003556 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6777 No 31026505 hsa_circ_000145 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4395 No 31026505 hsa_circ_001936 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6776 No 31026505 hsa_circ_006453 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6775 No 31026505 hsa_circ_002859 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4396 No 31026505 hsa_circ_006559 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6774 No 31026505 hsa_circ_004169 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6806 No 31026505 hsa_circ_001659 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4366 No 31026505 hsa_circ_007211 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4365 No 31026505 hsa_circ_0076690 CircRNA Homo sapiens Osteoporosis blood interaction[sponging miR-152] qRT-PCR Hsa_circ_0076690 expression was significantly decreased in osteoporosis patients compared to control and showed an acceptable diagnostic value in clinical samples. In conclusion, our study revealed that hsa_circ_0076690 may act as a potential diagnostic biomarker for osteoporosis patients and hsa_circ_0076690 could regulate osteogenic differentiation of hBMSCs via sponging miR-152. No 32717724 hsa_circ_006546 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4325 No 31026505 circAFF2 CircRNA Homo sapiens Leukemia, Myelomonocytic, Juvenile blood Expression[highly expressed] qRT-PCR//RNA-seq Validation of a set of deregulated circRNAs in an independent cohort of JMML patients confirmed the down-regulation of circOXNAD1 and circATM, and a marked up-regulation of circLYN, circAFF2, and circMCTP1. No 33490078 hsa_circ_004153 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4326 No 31026505 circLYN CircRNA Homo sapiens Leukemia, Myelomonocytic, Juvenile blood Expression[highly expressed] qRT-PCR//RNA-seq Validation of a set of deregulated circRNAs in an independent cohort of JMML patients confirmed the down-regulation of circOXNAD1 and circATM, and a marked up-regulation of circLYN, circAFF2, and circMCTP1. No 33490078 circATM CircRNA Homo sapiens Leukemia, Myelomonocytic, Juvenile blood Expression[lower expressed] qRT-PCR//RNA-seq Validation of a set of deregulated circRNAs in an independent cohort of JMML patients confirmed the down-regulation of circOXNAD1 and circATM, and a marked up-regulation of circLYN, circAFF2, and circMCTP1. No 33490078 hsa_circ_005300 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4327 No 31026505 circOXNAD1 CircRNA Homo sapiens Leukemia, Myelomonocytic, Juvenile blood Expression[lower expressed] qRT-PCR//RNA-seq Validation of a set of deregulated circRNAs in an independent cohort of JMML patients confirmed the down-regulation of circOXNAD1 and circATM, and a marked up-regulation of circLYN, circAFF2, and circMCTP1. No 33490078 hsa_circ_007284 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4328 No 31026505 hsa_circ_005392 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4329 No 31026505 hsa_circ_000009 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4330 No 31026505 hsa_circ_004031 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4331 No 31026505 hsa_circ_006107 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6832 No 31026505 hsa_circ_000719 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4332 No 31026505 hsa_circ_006590 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4333 No 31026505 hsa_circ_006953 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4334 No 31026505 hsa_circ_004716 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4335 No 31026505 hsa_circ_000429 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6831 No 31026505 hsa_circ_002370 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6830 No 31026505 hsa_circ_002455 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4336 No 31026505 hsa_circ_003522 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4337 No 31026505 hsa_circ_001406 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6829 No 31026505 hsa_circ_004899 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6828 No 31026505 hsa_circ_000189 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6827 No 31026505 hsa_circ_000277 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4338 No 31026505 hsa_circ_002073 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6826 No 31026505 hsa_circ_003943 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6825 No 31026505 hsa_circ_004030 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4324 No 31026505 circMCTP1 CircRNA Homo sapiens Leukemia, Myelomonocytic, Juvenile blood Expression[highly expressed] qRT-PCR//RNA-seq Validation of a set of deregulated circRNAs in an independent cohort of JMML patients confirmed the down-regulation of circOXNAD1 and circATM, and a marked up-regulation of circLYN, circAFF2, and circMCTP1. No 33490078 hsa_circ_0005583 CircRNA Homo sapiens Optic Neuropathy, Ischemic blood Expression[highly expressed] qRT-PCR//RNA-seq There were significant differences in the expression of 49 circRNAs in the peripheral blood of NAION patients, in which there were 24 upregulations and 25 downregulations (variation folds > 2 and P < 0.05), and it was confirmed that hsa_circ_0005583, hsa_circ_0003922, hsa_circ_0002021, and hsa_circ_0000462 were significantly downregulated (variation folds > 2 and P < 0.05), especially hsa_circ_0005583 which was the most significantly changed one (P < 0.001), and are related to processes such as neurodegeneration, oxidative stress, immunity, and metabolism. No 33294447 hsa_circ_002544 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6841 No 31026505 hsa_circ_006865 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6840 No 31026505 hsa_circ_004878 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6839 No 31026505 hsa_circ_000055 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6838 No 31026505 hsa_circ_001293 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6837 No 31026505 hsa_circ_006039 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4315 No 31026505 hsa_circ_0000462 CircRNA Homo sapiens Optic Neuropathy, Ischemic blood Expression[highly expressed] qRT-PCR//RNA-seq There were significant differences in the expression of 49 circRNAs in the peripheral blood of NAION patients, in which there were 24 upregulations and 25 downregulations (variation folds > 2 and P < 0.05), and it was confirmed that hsa_circ_0005583, hsa_circ_0003922, hsa_circ_0002021, and hsa_circ_0000462 were significantly downregulated (variation folds > 2 and P < 0.05), especially hsa_circ_0005583 which was the most significantly changed one (P < 0.001), and are related to processes such as neurodegeneration, oxidative stress, immunity, and metabolism. No 33294447 hsa_circ_0002021 CircRNA Homo sapiens Optic Neuropathy, Ischemic blood Expression[highly expressed] qRT-PCR//RNA-seq There were significant differences in the expression of 49 circRNAs in the peripheral blood of NAION patients, in which there were 24 upregulations and 25 downregulations (variation folds > 2 and P < 0.05), and it was confirmed that hsa_circ_0005583, hsa_circ_0003922, hsa_circ_0002021, and hsa_circ_0000462 were significantly downregulated (variation folds > 2 and P < 0.05), especially hsa_circ_0005583 which was the most significantly changed one (P < 0.001), and are related to processes such as neurodegeneration, oxidative stress, immunity, and metabolism. No 33294447 hsa_circ_001050 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4316 No 31026505 hsa_circ_001592 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4317 No 31026505 hsa_circ_006659 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4318 No 31026505 hsa_circ_0003922 CircRNA Homo sapiens Optic Neuropathy, Ischemic blood Expression[highly expressed] qRT-PCR//RNA-seq There were significant differences in the expression of 49 circRNAs in the peripheral blood of NAION patients, in which there were 24 upregulations and 25 downregulations (variation folds > 2 and P < 0.05), and it was confirmed that hsa_circ_0005583, hsa_circ_0003922, hsa_circ_0002021, and hsa_circ_0000462 were significantly downregulated (variation folds > 2 and P < 0.05), especially hsa_circ_0005583 which was the most significantly changed one (P < 0.001), and are related to processes such as neurodegeneration, oxidative stress, immunity, and metabolism. No 33294447 hsa_circ_000377 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6836 No 31026505 hsa_circ_006218 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6835 No 31026505 hsa_circ_0001946 CircRNA Homo sapiens Coronary Artery Disease peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Hsa_circ_0001946 was validated to be significantly up-regulated in the peripheral blood mononuclear cells of CHD patients, and revealed as an independent indicator of increased CHD risk (odds ratio: 2.364; 95% confidence interval [CI]: 1.765-3.165) after adjusting for confounding factors. No 33326806 hsa_circ_004022 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6834 No 31026505 hsa_circ_004368 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4319 No 31026505 hsa_circ_001800 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6833 No 31026505 hsa_circ_006954 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4320 No 31026505 hsa_circ_003405 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4321 No 31026505 hsa_circ_003423 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4322 No 31026505 hsa_circ_006538 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4323 No 31026505 hsa_circ_0011269 CircRNA Homo sapiens Osteoporosis osteoporosis tissues regulation[miR-122,RUNX2 ] qRT-PCR We found that circ_0011269 was notably downregulated in osteoporosis (fold change, 3.94). In summary, this study found that circ_0011269 sponges miR-122 to regulate RUNX2 expression and promotes osteoporosis progression. No 32619044 hsa_circ_0002060 CircRNA Homo sapiens Osteoporosis blood Expression[highly expressed] qRT-PCR As a result, circ_0006873 and circ_0002060 were found to be significantly upregulated between nonosteoporotic controls and osteoporosis patients (n = 40, respectively). Pearson correlation analysis showed that the level of circ_0006873 and circ_0002060 were associated with the low-bone mineral density in patients with osteoporosis. Furthermore, ROC analysis indicated that circ_0002060 showed potential diagnostic value for osteoporosis. No 31056800 hsa_circ_001831 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6807 No 31026505 hsa_circ_0006873 CircRNA Homo sapiens Osteoporosis blood Expression[highly expressed] qRT-PCR As a result, circ_0006873 and circ_0002060 were found to be significantly upregulated between nonosteoporotic controls and osteoporosis patients (n = 40, respectively). Pearson correlation analysis showed that the level of circ_0006873 and circ_0002060 were associated with the low-bone mineral density in patients with osteoporosis. Furthermore, ROC analysis indicated that circ_0002060 showed potential diagnostic value for osteoporosis. No 31056800 hsa_circ_0080888 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_006956 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6810 No 31026505 hsa_circ_0005754 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_005897 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4347 No 31026505 hsa_circ_004175 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4348 No 31026505 hsa_circ_0087206 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_002736 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4349 No 31026505 hsa_circ_002607 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4350 No 31026505 hsa_circ_000286 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6809 No 31026505 hsa_circ_001142 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4351 No 31026505 hsa_circ_004286 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4352 No 31026505 hsa_circ_000164 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4353 No 31026505 hsa_circ_000802 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4354 No 31026505 hsa_circ_002793 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4355 No 31026505 hsa_circ_005130 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6808 No 31026505 hsa_circ_001715 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4356 No 31026505 hsa_circ_002850 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4357 No 31026505 hsa_circ_003940 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4358 No 31026505 hsa_circ_002849 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4359 No 31026505 hsa_circ_002397 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4360 No 31026505 hsa_circ_005560 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4361 No 31026505 hsa_circ_0002091 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_0001946 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_000075 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4362 No 31026505 hsa_circ_0017695 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_001536 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4363 No 31026505 hsa_circ_007198 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4364 No 31026505 hsa_circ_0025367 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_005258 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6811 No 31026505 hsa_circ_005916 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6812 No 31026505 hsa_circ_002082 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6817 No 31026505 hsa_circ_003684 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6824 No 31026505 hsa_circ_006695 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6823 No 31026505 hsa_circ_006402 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6822 No 31026505 hsa_circ_005180 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4339 No 31026505 hsa_circ_003164 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6821 No 31026505 hsa_circ_005393 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6820 No 31026505 hsa_circ_002499 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4340 No 31026505 hsa_circ_006667 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4341 No 31026505 hsa_circ_0048871 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_001383 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6819 No 31026505 hsa_circ_005332 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6818 No 31026505 hsa_circ_0048870 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_000044 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4342 No 31026505 hsa_circ_0080897 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_003376 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6816 No 31026505 hsa_circ_0048892 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_005058 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6815 No 31026505 hsa_circ_006337 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6814 No 31026505 hsa_circ_004050 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4343 No 31026505 hsa_circ_0048867 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_001622 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4344 No 31026505 hsa_circ_002373 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6813 No 31026505 hsa_circ_0048858 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_004101 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4345 No 31026505 hsa_circ_006685 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4346 No 31026505 hsa_circ_0048861 CircRNA Homo sapiens Gastrointestinal Stromal Tumors GIST tissues Expression[differently-expression] qRT-PCR//Microarray In total, 1,815 mRNAs (839 upregulated mRNAs and 976 downregulated mRNAs) (Table 1) and 5,770 circRNAs (3,122 upregulated circRNAs and 2,648 downregulated circRNAs) (Table 2) were differentially expressed between the GIST and adjacent normal gastrointestinal tissue samples (p < 0.05 and FC ≥ ± 2). No 31552107 hsa_circ_005173 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6763 No 31026505 hsa_circ_005108 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4412 No 31026505 hsa_circ_004016 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6416 No 31026505 hsa_circ_005728 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4475 No 31026505 hsa_circ_003369 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6683 No 31026505 hsa_circ_001198 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4476 No 31026505 hsa_circ_000209 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4477 No 31026505 hsa_circ_004801 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4478 No 31026505 circLAMP1 CircRNA Homo sapiens Precursor T-Cell Lymphoblastic Leukemia-Lymphoma T-LBL tissues,cell lines Regulation[miR-615-5p/DDR2 signaling] CCK8//qRT-PCR//Luciferase Report Assay//Flow Cytometry In this work, we first screened the differentially expressed circRNAs between T-LBL tissues and normal infantile thymus and circ-LAMP1 was identified the highest expressed circRNA in cancerous tissues. qRT-PCR further verified its upregulation in T-LBL tissues and cell lines.Dual-luciferase reporter system further identified that miR-615-5p could be sponged by circ-LAMP1 and discoidin domain receptor tyrosine kinase 2 (DDR2) 3'-UTR is the direct target of miR-615-5p. Rescue assays demonstrated that the biological function of circ-LAMP1 is partly attributed to the modulation of miR-615-5p/DDR2 signaling. In summary, these findings documented that circ-LAMP1 might be an oncogene in T-LBL, which might be useful in developing promising therapies for T-LBL. No 30922709 hsa_circ_002757 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4479 No 31026505 hsa_circ_002788 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4480 No 31026505 hsa_circ_002386 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4481 No 31026505 hsa_circ_005662 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6682 No 31026505 hsa_circ_004056 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4482 No 31026505 hsa_circ_006765 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6681 No 31026505 hsa_circ_007057 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6680 No 31026505 hsa_circ_004871 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6679 No 31026505 hsa_circ_007065 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4483 No 31026505 hsa_circ_000080 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4484 No 31026505 hsa_circ_003377 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6678 No 31026505 hsa_circ_006031 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4485 No 31026505 hsa_circ_006658 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4486 No 31026505 hsa_circ_000184 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4487 No 31026505 hsa_circ_003398 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4488 No 31026505 hsa_circ_005578 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6677 No 31026505 hsa_circ_003963 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4489 No 31026505 hsa_circ_000838 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6676 No 31026505 hsa_circ_001311 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6675 No 31026505 hsa_circ_001867 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6674 No 31026505 hsa_circ_003389 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6673 No 31026505 hsa_circ_005855 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4490 No 31026505 hsa_circ_006072 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6684 No 31026505 hsa_circ_000340 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4474 No 31026505 circMBNL1 CircRNA Homo sapiens Aortic Dissection aortic tissues Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot The top 10 significantly differentially expressed circRNAs, 10 significantly differentially expressed miRs and 10 significantly differentially expressed mRNAs identified in the RNA-Seq analysis were selected for further qRT-PCR analysis. Thirty matched human AAAD and normal aortic tissues were used in this part, the results of qRT-PCR confirmed the up-regulation of circUBA2, circARHGAP26, circCHSY1, circMBNL1, circIQGAP1, circMED13, circMYH10, circRAB7A, hsa-miR-210-5p, hsa-miR-4521, hsa-miR-128-3p, hsa-miR-1180-5p, EPG5, ITGA2B, TANC2, FGR, IL-1α and TEAD2 and the down-regulation of circCEP70, circFAM120B, hsa-miR-622, hsa-miR-6773-5p, hsa-miR-8071, hsa-miR-139-3p, hsa-miR-187-3p, hsa-miR-1273-3p, FGD5, FOXF1,CDH5 and KCNK5 (Figs 2A–2T and S1). No 31251793 hsa_circ_003553 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4473 No 31026505 hsa_circ_003356 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4458 No 31026505 hsa_circ_003740 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4459 No 31026505 hsa_circ_001546 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4460 No 31026505 hsa_circ_006805 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4461 No 31026505 circCRAMP1L CircRNA Homo sapiens Pre-Eclampsia blood regulation[MSP/RON axis] qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay circCRAMP1L circulating levels were significantly lower in patients with preeclampsia (2.66 ± 0.82, △Ct value) than in healthy pregnant women (3.95 ± 0.67, △Ct value, p < 0.001). RNA immunoprecipitation and luciferase reporter gene illustrated that circCRAMP1L participated in regulation of trophoblast cell by regulating MSP. No 33109096 hsa_circ_006896 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6694 No 31026505 hsa_circ_006883 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6693 No 31026505 hsa_circ_001872 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4462 No 31026505 hsa_circ_003769 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4463 No 31026505 hsa_circ_007310 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4464 No 31026505 circTNFRSF21 CircRNA Homo sapiens Skin Neoplasms cSCC tissue Interaction(circ_TNFRSF21/miR-3619-5p/ROCK axis) Western Blot//Transfection//Tube Formation Assay//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Invasion Assay//Transwell Assay Circ_TNFRSF21 and ROCK2 were upregulated in cSCC tissue, while miR-3619-5p was downregulated. Circ_TNFRSF21 negatively regulated the expression of miR-3619-5p, while miR-3619-5p negatively regulated the expression of ROCK2. miR-3619-5p suppressed tube formation by inhibiting ROCK signaling. No 35593591 hsa_circ_007291 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4465 No 31026505 hsa_circ_002319 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6692 No 31026505 hsa_circ_002697 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6691 No 31026505 hsa_circ_003921 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4466 No 31026505 hsa_circ_004024 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6690 No 31026505 hsa_circ_000245 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6689 No 31026505 hsa_circ_006518 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4467 No 31026505 hsa_circ_001428 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6688 No 31026505 hsa_circ_004092 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6687 No 31026505 hsa_circ_005596 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4468 No 31026505 hsa_circ_001379 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4469 No 31026505 hsa_circ_003492 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4470 No 31026505 hsa_circ_001277 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4471 No 31026505 hsa_circ_004307 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6686 No 31026505 hsa_circ_001903 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4472 No 31026505 hsa_circ_006213 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6685 No 31026505 hsa_circ_0064900 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[lower expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_005402 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4491 No 31026505 hsa_circ_0043144 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[lower expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_003895 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4492 No 31026505 hsa_circ_000251 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6670 No 31026505 hsa_circ_003914 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6669 No 31026505 hsa_circ_007205 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4500 No 31026505 hsa_circ_001565 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6668 No 31026505 hsa_circ_005987 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4501 No 31026505 hsa_circ_000565 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6667 No 31026505 hsa_circ_005021 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4502 No 31026505 hsa_circ_007307 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6666 No 31026505 hsa_circ_004541 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6665 No 31026505 hsa_circ_005943 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6664 No 31026505 hsa_circ_000388 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6663 No 31026505 hsa_circ_006705 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6662 No 31026505 hsa_circ_005617 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4503 No 31026505 hsa_circ_007283 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6661 No 31026505 hsa_circ_003804 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6660 No 31026505 hsa_circ_005695 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6659 No 31026505 hsa_circ_006232 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6658 No 31026505 hsa_circ_005222 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4504 No 31026505 hsa_circ_000807 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6657 No 31026505 hsa_circ_001297 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4505 No 31026505 hsa_circ_004090 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4506 No 31026505 hsa_circ_002244 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4507 No 31026505 hsa_circ_003153 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6656 No 31026505 hsa_circ_004237082 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_006366 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6655 No 31026505 hsa_circ_005177 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6654 No 31026505 hsa_circ_002714 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6653 No 31026505 hsa_circ_004429 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6671 No 31026505 hsa_circ_004440 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6672 No 31026505 circZNF609 CircRNA Homo sapiens Rhabdomyosarcoma embryonal and alveolar Interaction[G1-S] Flow Cytometry//qRT-PCR//Western Blot We found that circ-ZNF609 is upregulated in biopsies from the two major RMS subtypes, embryonal (ERMS) and alveolar (ARMS). Moreover, we discovered that in an ERMS-derived cell line circ-ZNF609 knock-down induced a specific block at the G1-S transition, a strong decrease of p-Akt protein level and an alteration of the pRb/Rb ratio. Regarding p-Akt, we were able to show that circ-ZNF609 acts by counteracting p-Akt proteasome-dependent degradation, thus working as a new regulator of cell proliferation-related pathways. As opposed to ERMS-derived cells, the circRNA depletion had no cell cycle effects in ARMS-derived cells. Since in these cells the p53 gene resulted downregulated, with a concomitant upregulation of its cell cycle-related target genes, we suggest that this could account for the lack of circ-ZNF609 effect in ARMS. No 30670781 hsa_circ_0000074 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[lower expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_000203 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4493 No 31026505 hsa_circ_005243 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4494 No 31026505 hsa_circ_0001744 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[lower expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_0031660 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[lower expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_0051785 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[lower expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_004076 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4495 No 31026505 hsa_circ_0077995 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[lower expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_001769 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4496 No 31026505 hsa_circ_0075043 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[lower expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_002165 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4497 No 31026505 hsa_circ_0056158 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[lower expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_0025453 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[lower expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_0000364 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[highly expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 circMAN1A2 CircRNA Homo sapiens cancer malignant tumors tissues Expression[highly expressed] qRT-PCR The results showed that circMAN1A2 was upregulated in nasopharyngeal carcinoma, oral cancer, thyroid cancer, ovarian cancer, and lung cancer, with areas under the curves of 0.911, 0.779, 0.734, 0.694, and 0.645, respectively, indicating the good diagnostic value of circMAN1A2. No 31046163 hsa_circ_0051433 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[highly expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_0026466 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[highly expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_0002136 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[highly expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_0043926 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[highly expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_0001853 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[highly expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_0000157 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[highly expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_0003003 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[highly expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_001097 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4498 No 31026505 hsa_circ_0004903 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[highly expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_0007294 CircRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[highly expressed] qRT-PCR//Microarray The top ten most significant circRNAs and mRNAs ranked by FC are summarized in Table 2 and Table 3, respectively. No 32606648 hsa_circ_004649 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4499 No 31026505 hsa_circ_006297 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6695 No 31026505 hsa_circ_001668 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4457 No 31026505 hsa_circ_006299 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6696 No 31026505 hsa_circ_004288 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6727 No 31026505 hsa_circ_004386 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6745 No 31026505 hsa_circ_000819 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6744 No 31026505 hsa_circ_002764 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6743 No 31026505 hsa_circ_001212 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6742 No 31026505 hsa_circ_005838 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6741 No 31026505 hsa_circ_001440 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6740 No 31026505 hsa_circ_007262 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4418 No 31026505 hsa_circ_002355 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6739 No 31026505 hsa_circ_005111 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4419 No 31026505 hsa_circ_006002 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4420 No 31026505 hsa_circ_000897 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4421 No 31026505 hsa_circ_003497 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6738 No 31026505 hsa_circ_003175 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4422 No 31026505 hsa_circ_000736 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6737 No 31026505 hsa_circ_004533 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6736 No 31026505 hsa_circ_005751 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6735 No 31026505 hsa_circ_003806 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6734 No 31026505 hsa_circ_006837 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4423 No 31026505 hsa_circ_002580 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6733 No 31026505 hsa_circ_007092 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4424 No 31026505 hsa_circ_001844 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6732 No 31026505 hsa_circ_005742 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4425 No 31026505 hsa_circ_005326 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4426 No 31026505 hsa_circ_001289 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6731 No 31026505 hsa_circ_007154 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6730 No 31026505 hsa_circ_003996 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6729 No 31026505 hsa_circ_005354 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6728 No 31026505 hsa_circ_000793 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6746 No 31026505 hsa_circ_001519 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6747 No 31026505 hsa_circ_004831 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6748 No 31026505 hsa_circ_005918 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6756 No 31026505 circCHSY1 CircRNA Homo sapiens Aortic Dissection aortic tissues Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot The top 10 significantly differentially expressed circRNAs, 10 significantly differentially expressed miRs and 10 significantly differentially expressed mRNAs identified in the RNA-Seq analysis were selected for further qRT-PCR analysis. Thirty matched human AAAD and normal aortic tissues were used in this part, the results of qRT-PCR confirmed the up-regulation of circUBA2, circARHGAP26, circCHSY1, circMBNL1, circIQGAP1, circMED13, circMYH10, circRAB7A, hsa-miR-210-5p, hsa-miR-4521, hsa-miR-128-3p, hsa-miR-1180-5p, EPG5, ITGA2B, TANC2, FGR, IL-1α and TEAD2 and the down-regulation of circCEP70, circFAM120B, hsa-miR-622, hsa-miR-6773-5p, hsa-miR-8071, hsa-miR-139-3p, hsa-miR-187-3p, hsa-miR-1273-3p, FGD5, FOXF1,CDH5 and KCNK5 (Figs 2A–2T and S1). No 31251793 circARHGAP26 CircRNA Homo sapiens Aortic Dissection aortic tissues Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot The top 10 significantly differentially expressed circRNAs, 10 significantly differentially expressed miRs and 10 significantly differentially expressed mRNAs identified in the RNA-Seq analysis were selected for further qRT-PCR analysis. Thirty matched human AAAD and normal aortic tissues were used in this part, the results of qRT-PCR confirmed the up-regulation of circUBA2, circARHGAP26, circCHSY1, circMBNL1, circIQGAP1, circMED13, circMYH10, circRAB7A, hsa-miR-210-5p, hsa-miR-4521, hsa-miR-128-3p, hsa-miR-1180-5p, EPG5, ITGA2B, TANC2, FGR, IL-1α and TEAD2 and the down-regulation of circCEP70, circFAM120B, hsa-miR-622, hsa-miR-6773-5p, hsa-miR-8071, hsa-miR-139-3p, hsa-miR-187-3p, hsa-miR-1273-3p, FGD5, FOXF1,CDH5 and KCNK5 (Figs 2A–2T and S1). No 31251793 circUBA2 CircRNA Homo sapiens Aortic Dissection aortic tissues Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot The top 10 significantly differentially expressed circRNAs, 10 significantly differentially expressed miRs and 10 significantly differentially expressed mRNAs identified in the RNA-Seq analysis were selected for further qRT-PCR analysis. Thirty matched human AAAD and normal aortic tissues were used in this part, the results of qRT-PCR confirmed the up-regulation of circUBA2, circARHGAP26, circCHSY1, circMBNL1, circIQGAP1, circMED13, circMYH10, circRAB7A, hsa-miR-210-5p, hsa-miR-4521, hsa-miR-128-3p, hsa-miR-1180-5p, EPG5, ITGA2B, TANC2, FGR, IL-1α and TEAD2 and the down-regulation of circCEP70, circFAM120B, hsa-miR-622, hsa-miR-6773-5p, hsa-miR-8071, hsa-miR-139-3p, hsa-miR-187-3p, hsa-miR-1273-3p, FGD5, FOXF1,CDH5 and KCNK5 (Figs 2A–2T and S1). No 31251793 hsa_circ_004758 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6761 No 31026505 hsa_circ_003019 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6760 No 31026505 hsa_circ_004536 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6759 No 31026505 hsa_circ_001931 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6758 No 31026505 hsa_circ_0085289 CircRNA Homo sapiens Periodontitis LPS-treated PDLCs Regulation(let-7f-5p/SOCS6 Pathway) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//ELISA Circ_0085289 and SOCS6 levels were reduced, and let-7f-5p level was increased in periodontitis patients and LPS-treated PDLCs. LPS stimulation caused PDLC injury and circ_0085289 downregulation. Moreover, circ_0085289 upregulation or let-7f-5p downregulation diminished LPS-triggered PDLC injury. Besides, circ_0085289 promoted SOCS6 expression by absorbing let-7f-5p. Circ_0085289 alleviated LPS-stimulated PDLC injury via targeting let-7f-5p. Moreover, let-7f-5p targeted SOCS6 to affect LPS-resulted PDLC injury. Circ_0085289 alleviated PDLC injury induced by LPS stimulation via modulating let-7f-5p/SOCS6 axis No 33710445 hsa_circ_0095812 CircRNA Homo sapiens Periodontitis gingival tissues Expression[highly expressed] qPCR//RNA-seq Subsequently, we have investigated the expression pattern of circ_0062491 (downregulated) and circ_0095812 (upregulated) among 30-paired periodontitis patients and healthy individuals by quantitative real-time polymerase chain reaction. Moreover, circ_0062491 was identified as the sponge of miR-584 which play a key role in periodontitis. No 31021476 hsa_circ_0062491 CircRNA Homo sapiens Periodontitis gingival tissues Interaction[ sponge of miR-584] qPCR//RNA-seq Subsequently, we have investigated the expression pattern of circ_0062491 (downregulated) and circ_0095812 (upregulated) among 30-paired periodontitis patients and healthy individuals by quantitative real-time polymerase chain reaction. Moreover, circ_0062491 was identified as the sponge of miR-584 which play a key role in periodontitis. No 31021476 hsa_circ_006229 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6757 No 31026505 hsa_circ_006869 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4413 No 31026505 hsa_circ_003467 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6755 No 31026505 hsa_circ_006121 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4417 No 31026505 circANRIL CircRNA Homo sapiens Mucocutaneous Lymph Node Syndrome blood Expression[lower expressed] qRT-PCR The serum levels of circANRIL were lower in patients with KD before therapy than in the controls, but became higher in the patients after therapy than before therapy. No 30843267 hsa_circ_001457 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6754 No 31026505 hsa_circ_005112 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6753 No 31026505 hsa_circ_002235 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4414 No 31026505 hsa_circ_001139 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4415 No 31026505 hsa_circ_004281 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6752 No 31026505 hsa_circ_002885 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6751 No 31026505 hsa_circ_007022 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4416 No 31026505 circMTO1 CircRNA Homo sapiens Liver Cirrhosis blood Interaction[ miR-17-5p and Smad7] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay Here, we found that serum circMTO1 was significantly down-regulated in chronic hepatitis B (CHB) patients.Taken together, we demonstrate that circMTO1 inhibits liver fibrosis via regulation of miR-17-5p and Smad7, and serum circMTO1 may be a novel promising biomarker of liver fibrosis. No 31148365 hsa_circ_000905 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6750 No 31026505 hsa_circ_0003574 CircRNA Homo sapiens Ischemic Stroke 5 NCs versus five patients with ICAS-stroke Expression(highly expressed) qPCR Only hsa_circRNA_0003574 was significantly upregulated in patients than in NCs. GO analysis indicated that predicted target genes involved various biological processes, cellular components, and molecular functions. No 36225588 hsa_circ_004984 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6749 No 31026505 hsa_circ_004658 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4427 No 31026505 hsa_circ_006671 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6726 No 31026505 hsa_circ_002426 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6697 No 31026505 hsa_circ_000817 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4428 No 31026505 hsa_circ_005167 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4442 No 31026505 hsa_circ_000200 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6709 No 31026505 hsa_circ_002965 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6708 No 31026505 hsa_circ_004623 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6707 No 31026505 hsa_circ_005015 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6706 No 31026505 hsa_circ_005060 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4443 No 31026505 hsa_circ_002288 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4444 No 31026505 hsa_circ_003640 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6705 No 31026505 hsa_circ_006834 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6704 No 31026505 hsa_circ_000818 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6703 No 31026505 hsa_circ_001468 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4445 No 31026505 hsa_circ_001315 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4446 No 31026505 hsa_circ_003457 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4447 No 31026505 hsa_circ_006413 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6702 No 31026505 hsa_circ_004088 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4448 No 31026505 hsa_circ_004700 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4449 No 31026505 hsa_circ_003229 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4450 No 31026505 hsa_circ_003705 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4451 No 31026505 hsa_circ_003755 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4452 No 31026505 hsa_circ_002906 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4453 No 31026505 hsa_circ_001271 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6701 No 31026505 hsa_circ_001575 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4454 No 31026505 hsa_circ_001750 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6700 No 31026505 hsa_circ_000759 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6699 No 31026505 hsa_circ_003162 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6698 No 31026505 hsa_circ_003814 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4455 No 31026505 hsa_circ_003131 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4456 No 31026505 hsa_circ_002952 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4441 No 31026505 hsa_circ_004908 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4440 No 31026505 hsa_circ_007096 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6710 No 31026505 hsa_circ_001218 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6718 No 31026505 hsa_circ_002071 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6725 No 31026505 hsa_circ_001649 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6724 No 31026505 hsa_circ_006028 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6723 No 31026505 circIGF1R CircRNA Homo sapiens Psoriasis HaCaT cells Regulation(miR-194-5p/CDK1 axis) Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay These results showed that circ-IGF1R could affect the proliferation, apoptosis, migration and invasion of IL-22-stimulated HaCaT cells by regulating the expression of miR-194-5p. Based on TargetScan prediction and dual luciferase reporter assays, it was shown that cyclin-dependent kinase (CDK)1 was targeted by miR-194-5p. Additionally, the expression of CDK1 was upregulated following stimulation with IL-22 in HaCaT cells at the mRNA and protein levels. Transfection of miR-194-5p mimic or miR-194-5p inhibitor negatively regulated CDK1 expression in the IL-22 induced HaCaT cells. In conclusion, circ-IGF1R-siRNA could inhibit the cell proliferation, migration and invasion, and induce apoptosis by regulating the miR-194-5p/CDK1 axis. circ-IGF1R may thus serve as a potential treatment target for psoriasis. No 34776628 hsa_circ_005492 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6722 No 31026505 hsa_circ_004331 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6721 No 31026505 hsa_circ_003835 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4429 No 31026505 hsa_circ_001692 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4430 No 31026505 hsa_circ_004531 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4431 No 31026505 hsa_circ_006054 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4432 No 31026505 hsa_circ_004946 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6720 No 31026505 hsa_circ_005511 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6719 No 31026505 hsa_circ_001466 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4433 No 31026505 hsa_circ_003946 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6711 No 31026505 hsa_circ_002552 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6717 No 31026505 hsa_circ_005465 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4434 No 31026505 hsa_circ_002000 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4435 No 31026505 hsa_circ_005077 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4436 No 31026505 hsa_circ_000247 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6716 No 31026505 hsa_circ_000279 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4437 No 31026505 hsa_circ_004466 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6715 No 31026505 hsa_circ_001042 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4438 No 31026505 hsa_circ_006265 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6714 No 31026505 hsa_circ_003101 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6713 No 31026505 hsa_circ_001138 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6712 No 31026505 hsa_circ_000219 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4439 No 31026505 hsa_circ_005971 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4314 No 31026505 hsa_circ_004182 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4313 No 31026505 hsa_circ_003285 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4312 No 31026505 hsa_circ_003916 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4154 No 31026505 hsa_circ_001973 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4156 No 31026505 hsa_circ_16316-13 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and36). No 32419790 hsa_circ_0140760 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and35). No 32419790 hsa_circ_005759 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4157 No 31026505 hsa_circ_006925 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6876 No 31026505 hsa_circ_002098 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4158 No 31026505 hsa_circ_0140759 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and34). No 32419790 hsa_circ_16316-10 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and33). No 32419790 hsa_circ_005750 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6875 No 31026505 hsa_circ_007147 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6874 No 31026505 hsa_circ_004654 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4159 No 31026505 circFUNDC1 CircRNA Homo sapiens Stroke Associated Infection blood Expression[highly expressed] qRT-PCR A significantly elevated level of circFUNDC1 was found in SAI patients compared with not infected AIS patients (P=0.0258). No 32537657 hsa_circ_002856 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4160 No 31026505 hsa_circ_004468 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4161 No 31026505 hsa_circ_001230 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4162 No 31026505 hsa_circ_004479 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4163 No 31026505 circPDE4B CircRNA Homo sapiens Retinopathy of Prematurity prematurity model,cells regulation[HIF-1α ,miR-181c] qRT-PCR In the present study, our data demonstrated that circPDE4B was downregulated, while hypoxia-inducible factor-1α (HIF-1α) and VEGFA were upregulated in the retinopathy of prematurity model in vitro and in vivo. In conclusion, circPDE4B suppressed the expression of VEGFA and pathological angiogenesis via promoting VHL-mediated ubiquitin degradation of HIF-1α through binding to miR-181c. No 32584521 hsa_circ_0049220 CircRNA Homo sapiens Lupus Erythematosus, Discoid Expression [lower expressed] qRT-PCR We found that the expressions of hsa_circ_0049224 and has_circ_0049220 in healthy control groups were both much higher than those in inactive and active SLE patients. The expression level of DNMT1 is positively correlated with the expressions of hsa_circ_0049224 and has_circ_0049220. Moreover, there was a negative correlation between the SLE Disease Activity Index (SLEDAI) and the expressions of hsa_circ_0049224 and has_circ_0049220. We also found that these 2 circRNAs are associated with some clinical characteristics of SLE. No 29606700 hsa_circ_002759 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4164 No 31026505 hsa_circ_007086 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4165 No 31026505 hsa_circ_005862 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4166 No 31026505 hsa_circ_005417 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4167 No 31026505 hsa_circ_0049224 CircRNA Homo sapiens Lupus Erythematosus, Discoid Expression [lower expressed] qRT-PCR We found that the expressions of hsa_circ_0049224 and has_circ_0049220 in healthy control groups were both much higher than those in inactive and active SLE patients. The expression level of DNMT1 is positively correlated with the expressions of hsa_circ_0049224 and has_circ_0049220. Moreover, there was a negative correlation between the SLE Disease Activity Index (SLEDAI) and the expressions of hsa_circ_0049224 and has_circ_0049220. We also found that these 2 circRNAs are associated with some clinical characteristics of SLE. No 29606700 hsa_circ_007208 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4168 No 31026505 hsa_circ_0012919 CircRNA Homo sapiens Lupus Erythematosus, Discoid blood Expression[highly expressed] qRT-PCR Expression of hsa_circ_0012919 and MDA5 were further confirmed to be significantly higher in CD4+ T cells of SLE patients (p < 0.05), methylation level of MDA5 promoter was significantly lower in CD4+ T cells of SLE patients (p < 0.05), and expression of MDA5 mRNA was correlated with SLE parameters (p < 0.05). No 32321346 hsa_circ_004032 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4169 No 31026505 hsa_circ_002132 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4170 No 31026505 hsa_circ_005798 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4155 No 31026505 hsa_circ_0140758 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and37). No 32419790 hsa_circ_004193 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6842 No 31026505 hsa_circ_16316-4 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and38). No 32419790 hsa_circ_000678 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4134 No 31026505 hsa_circ_004019 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4135 No 31026505 hsa_circ_002324 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4136 No 31026505 hsa_circ_000677 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4137 No 31026505 hsa_circ_0009024 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and44). No 32419790 hsa_circ_006946 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4138 No 31026505 hsa_circ_16316-9 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and43). No 32419790 hsa_circ_001326 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4139 No 31026505 hsa_circ_000602 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4140 No 31026505 hsa_circ_004183 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4141 No 31026505 hsa_circ_002226 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4142 No 31026505 hsa_circ_006712 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6877 No 31026505 hsa_circ_006584 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4143 No 31026505 hsa_circ_006665 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4144 No 31026505 hsa_circ_006632 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4145 No 31026505 hsa_circ_002094 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4146 No 31026505 hsa_circ_006603 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4147 No 31026505 hsa_circ_004328 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4148 No 31026505 hsa_circ_006087 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4149 No 31026505 hsa_circ_000898 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4150 No 31026505 hsa_circ_003866 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4151 No 31026505 hsa_circ_0003368 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and42). No 32419790 hsa_circ_0140736 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and41). No 32419790 hsa_circ_0140781 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and40). No 32419790 hsa_circ_16316-11 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and39). No 32419790 hsa_circ_006690 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4152 No 31026505 hsa_circ_006198 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4153 No 31026505 circSETD2 CircRNA Homo sapiens Abnormal Birth Weight placenta regulation[circRNA-SETD2/miR-519a/PTEN Axis] qRT-PCR//Luciferase Report Assay//Western Blot//Microarray The result identified that circ-SETD2 was highly expressed in the placenta of the patients with fetal macrosomia compared with healthy donors. These findings improve our understanding of the mechanisms of progression of fetal macrosomia and will guide future development of therapeutic strategies against the disease by targeting the circ-SETD2/miR-519a/PTEN axis. No 32626774 hsa_circ_003690 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4171 No 31026505 hsa_circ_006812 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6873 No 31026505 hsa_circ_005000 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4172 No 31026505 hsa_circ_000366 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4183 No 31026505 hsa_circ_002281 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4184 No 31026505 hsa_circ_003145 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_059085 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_405511 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_103181 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_051123 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_002796 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_002141 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_007624 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_102232 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_100166 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_006120 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4185 No 31026505 hsa_circ_002530 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4186 No 31026505 hsa_circ_103601 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_001695 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_400696 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_002218 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4187 No 31026505 hsa_circ_403457 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_006710 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_000883 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_406768 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_006604 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_102166 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_104940 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_404655 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_400185 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_004452 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4182 No 31026505 hsa_circ_003195 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4181 No 31026505 hsa_circ_006817 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4180 No 31026505 hsa_circ_102551 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_0000977 CircRNA Homo sapiens Esophageal Neoplasms ESCC cells Interaction(miR-874-3p) Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Microarray//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay Disordered hsa_circ_0000977 expression can promote carcinogenesis in ESCC and might serve as a diagnostic biomarker to evaluate the occurrence and development of esophageal cancer Hsa_circ_0000977 was significantly upregulated in ESCC (p < 0.01) and had diagnostic value in ESCC. No 35476874 BTBD7_hsa_circ_0000563 CircRNA Homo sapiens Carotid Stenosis atherosclerotic stenosis tissues Expression[lower expressed] qRT-PCR The RT-qPCR assay revealed that coronary artery segments with severe atherosclerotic stenosis had significantly low BTBD7_hsa_circ_0000563 levels. No 32710445 hsa_circ_004057 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6872 No 31026505 hsa_circ_000102 CircRNA Homo sapiens Graves Disease Serum exosomes Expression[highly expressed] qRT-PCR//Microarray The intronic circRNA hsa_circRNA_000102 was confirmed as an up-regulated component in plasma exosomes from patients with GD. No 32727578 hsa_circ_100981 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_100900 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_004365 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4173 No 31026505 hsa_circ_068259 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_104168 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_000328 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_402731 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_406350 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_003099 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4174 No 31026505 hsa_circ_002734 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4179 No 31026505 hsa_circ_102552 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_003671 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_003687 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4175 No 31026505 hsa_circ_403560 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_005866 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4176 No 31026505 hsa_circ_001752 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_008142 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_100812 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_407124 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_000274 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4177 No 31026505 hsa_circ_092478 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_002197 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4178 No 31026505 hsa_circ_000107 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4133 No 31026505 hsa_circ_003255 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4132 No 31026505 hsa_circ_0140746 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and45). No 32419790 hsa_circ_0107597 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and65). No 32419790 hsa_circ_006555 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4067 No 31026505 hsa_circ_0052193 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and70). No 32419790 hsa_circ_006227 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4068 No 31026505 hsa_circ_004730 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4069 No 31026505 hsa_circ_006776 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4070 No 31026505 hsa_circ_005843 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4071 No 31026505 hsa_circ_001856 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4072 No 31026505 hsa_circ_007321 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4073 No 31026505 hsa_circ_0140697 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and69). No 32419790 hsa_circ_0003086 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and68). No 32419790 hsa_circ_000085 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4074 No 31026505 hsa_circ_0058143 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and67). No 32419790 hsa_circ_001144 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4075 No 31026505 hsa_circ_000397 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4076 No 31026505 hsa_circ_007320 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4077 No 31026505 hsa_circ_006932 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4078 No 31026505 hsa_circ_003997 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4079 No 31026505 hsa_circ_000638 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4080 No 31026505 hsa_circ_001648 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4081 No 31026505 hsa_circ_002118 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4082 No 31026505 hsa_circ_004697 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4083 No 31026505 hsa_circ_002681 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4084 No 31026505 hsa_circ_002266 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4085 No 31026505 hsa_circ_003343 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4086 No 31026505 hsa_circ_002855 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4087 No 31026505 hsa_circ_0061370 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and66). No 32419790 hsa_circ_000050 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4088 No 31026505 hsa_circ_002227 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4066 No 31026505 hsa_circ_0140547 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and71). No 32419790 hsa_circ_000326 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4065 No 31026505 hsa_circ_002979 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4051 No 31026505 hsa_circ_002282 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6878 No 31026505 hsa_circ_0046285 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and74). No 32419790 hsa_circ_004371 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4042 No 31026505 hsa_circ_0140549 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and73). No 32419790 hsa_circ_005882 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4043 No 31026505 hsa_circ_002441 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4044 No 31026505 hsa_circ_002589 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4045 No 31026505 hsa_circ_003100 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4046 No 31026505 hsa_circ_002560 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4047 No 31026505 hsa_circ_007235 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4048 No 31026505 hsa_circ_001332 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4049 No 31026505 hsa_circ_002794 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4050 No 31026505 hsa_circ_000883 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4052 No 31026505 hsa_circ_001131 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4064 No 31026505 hsa_circ_002612 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4053 No 31026505 hsa_circ_003494 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4054 No 31026505 hsa_circ_001145 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4055 No 31026505 hsa_circ_001003 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4056 No 31026505 hsa_circ_003648 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4057 No 31026505 hsa_circ_005254 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4058 No 31026505 hsa_circ_005497 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4059 No 31026505 hsa_circ_0140553 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and72). No 32419790 hsa_circ_005964 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4060 No 31026505 hsa_circ_005297 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4061 No 31026505 hsa_circ_005679 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4062 No 31026505 hsa_circ_005867 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4063 No 31026505 hsa_circ_002424 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4089 No 31026505 hsa_circ_13156-4 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and64). No 32419790 hsa_circ_003691 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4131 No 31026505 hsa_circ_006846 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4090 No 31026505 hsa_circ_004460 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4112 No 31026505 hsa_circ_001838 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4113 No 31026505 hsa_circ_002143 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4114 No 31026505 hsa_circ_002131 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4115 No 31026505 hsa_circ_0076034 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and53). No 32419790 hsa_circ_16316-7 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and52). No 32419790 hsa_circ_006216 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4116 No 31026505 hsa_circ_006625 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4117 No 31026505 hsa_circ_001041 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4118 No 31026505 hsa_circ_0140780 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and51). No 32419790 hsa_circ_0007907 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and50). No 32419790 hsa_circ_001503 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4119 No 31026505 hsa_circ_006338 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4120 No 31026505 hsa_circ_005694 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4121 No 31026505 hsa_circ_16316-1 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and49). No 32419790 hsa_circ_0140783 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and48). No 32419790 hsa_circ_006159 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4122 No 31026505 hsa_circ_001418 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4123 No 31026505 hsa_circ_006205 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4124 No 31026505 hsa_circ_000042 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4125 No 31026505 hsa_circ_005638 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4126 No 31026505 hsa_circ_16316-12 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and47). No 32419790 hsa_circ_003838 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4127 No 31026505 hsa_circ_002715 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4128 No 31026505 hsa_circ_16316-2 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[highly expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and46). No 32419790 hsa_circ_007274 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4129 No 31026505 hsa_circ_001222 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4130 No 31026505 hsa_circ_001096 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4111 No 31026505 hsa_circ_0140537 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and54). No 32419790 hsa_circ_001637 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4110 No 31026505 hsa_circ_000668 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4099 No 31026505 hsa_circ_005569 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4091 No 31026505 hsa_circ_003680 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4092 No 31026505 hsa_circ_0140541 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and63). No 32419790 hsa_circ_0140536 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and62). No 32419790 hsa_circ_005474 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4093 No 31026505 hsa_circ_002484 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4094 No 31026505 hsa_circ_001680 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4095 No 31026505 hsa_circ_0140540 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and61). No 32419790 hsa_circ_16166-1 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and60). No 32419790 hsa_circ_006987 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4096 No 31026505 hsa_circ_000952 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4097 No 31026505 hsa_circ_004172 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4098 No 31026505 hsa_circ_004877 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4100 No 31026505 hsa_circ_000635 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4109 No 31026505 hsa_circ_16166-3 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and59). No 32419790 hsa_circ_002456 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4101 No 31026505 hsa_circ_005236 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4102 No 31026505 hsa_circ_000284 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4103 No 31026505 hsa_circ_0140539 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and58). No 32419790 hsa_circ_0091073 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and57). No 32419790 hsa_circ_001094 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4104 No 31026505 hsa_circ_004431 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4105 No 31026505 hsa_circ_002921 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4106 No 31026505 hsa_circ_0140538 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and56). No 32419790 hsa_circ_003828 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4107 No 31026505 hsa_circ_005749 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4108 No 31026505 hsa_circ_023576 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_103348 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_102966 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_001632 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4270 No 31026505 hsa_circ_006672 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4246 No 31026505 hsa_circ_006504 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4247 No 31026505 hsa_circ_002353 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4248 No 31026505 hsa_circ_003909 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4249 No 31026505 hsa_circ_007224 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4250 No 31026505 hsa_circ_002665 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4251 No 31026505 hsa_circ_002664 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4252 No 31026505 hsa_circ_000874 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4253 No 31026505 hsa_circ_102817 LncRNA Homo sapiens Myelodysplastic Syndromes 100 MDS patients and 20 controls Expression [lower expressed] Bioinformatics Analysis Validated by real-time quantitative PCR between 100 MDS patients and 20 controls, three upregulated (hsa_circRNA_100352, hsa_circRNA_104056, and hsa_circRNA_104634) and three downregulated (hsa_circRNA_103846, hsa_circRNA_102817, and hsa_circRNA_102526) circRNAs matched the arrays. Kaplan-Meier survival analysis showed that only hsa_circRNA_100352, hsa_circRNA_104056, and hsa_circRNA_102817 were significantly associated with overall survival.  No 33560542 hsa_circ_006368 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4254 No 31026505 hsa_circ_001870 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4255 No 31026505 hsa_circ_001070 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4256 No 31026505 hsa_circ_006209 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4257 No 31026505 hsa_circ_001456 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4258 No 31026505 hsa_circ_002410 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4259 No 31026505 hsa_circ_103846 LncRNA Homo sapiens Myelodysplastic Syndromes 100 MDS patients and 20 controls Expression [lower expressed] Bioinformatics Analysis Validated by real-time quantitative PCR between 100 MDS patients and 20 controls, three upregulated (hsa_circRNA_100352, hsa_circRNA_104056, and hsa_circRNA_104634) and three downregulated (hsa_circRNA_103846, hsa_circRNA_102817, and hsa_circRNA_102526) circRNAs matched the arrays. No 33560542 hsa_circ_001742 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4260 No 31026505 hsa_circ_002327 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4261 No 31026505 hsa_circ_001846 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4262 No 31026505 hsa_circ_002164 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4263 No 31026505 hsa_circ_104634 LncRNA Homo sapiens Myelodysplastic Syndromes 100 MDS patients and 20 controls Expression [highly expressed] Bioinformatics Analysis Validated by real-time quantitative PCR between 100 MDS patients and 20 controls, three upregulated (hsa_circRNA_100352, hsa_circRNA_104056, and hsa_circRNA_104634) and three downregulated (hsa_circRNA_103846, hsa_circRNA_102817, and hsa_circRNA_102526) circRNAs matched the arrays. No 33560542 hsa_circ_001448 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4264 No 31026505 hsa_circ_104056 LncRNA Homo sapiens Myelodysplastic Syndromes 100 MDS patients and 20 controls Expression [highly expressed] Bioinformatics Analysis Validated by real-time quantitative PCR between 100 MDS patients and 20 controls, three upregulated (hsa_circRNA_100352, hsa_circRNA_104056, and hsa_circRNA_104634) and three downregulated (hsa_circRNA_103846, hsa_circRNA_102817, and hsa_circRNA_102526) circRNAs matched the arrays. Kaplan-Meier survival analysis showed that only hsa_circRNA_100352, hsa_circRNA_104056, and hsa_circRNA_102817 were significantly associated with overall survival.  No 33560542 hsa_circ_001991 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4265 No 31026505 hsa_circ_002939 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4266 No 31026505 hsa_circ_005816 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4267 No 31026505 hsa_circ_000597 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4268 No 31026505 hsa_circ_001603 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4245 No 31026505 hsa_circ_000697 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4244 No 31026505 hsa_circ_102526 LncRNA Homo sapiens Myelodysplastic Syndromes 100 MDS patients and 20 controls Expression [lower expressed] Bioinformatics Analysis Validated by real-time quantitative PCR between 100 MDS patients and 20 controls, three upregulated (hsa_circRNA_100352, hsa_circRNA_104056, and hsa_circRNA_104634) and three downregulated (hsa_circRNA_103846, hsa_circRNA_102817, and hsa_circRNA_102526) circRNAs matched the arrays. No 33560542 hsa_circ_003884 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4233 No 31026505 hsa_circ_0006571 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[highly expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_001279 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4225 No 31026505 hsa_circ_0056686 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[highly expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_0020376 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[highly expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_000043 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4226 No 31026505 hsa_circ_006246 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4227 No 31026505 hsa_circ_0062558 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[highly expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_001878 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4228 No 31026505 hsa_circ_002452 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4229 No 31026505 hsa_circ_003176 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4230 No 31026505 hsa_circ_001075 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4231 No 31026505 hsa_circ_005394 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4232 No 31026505 hsa_circ_0083920 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[highly expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_005281 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4243 No 31026505 hsa_circ_002953 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4234 No 31026505 hsa_circ_001861 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4235 No 31026505 hsa_circ_006446 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4236 No 31026505 hsa_circ_005450 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4237 No 31026505 hsa_circ_006868 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4238 No 31026505 hsa_circ_005910 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6860 No 31026505 hsa_circ_000683 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4239 No 31026505 hsa_circ_007144 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6859 No 31026505 hsa_circ_007026 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6858 No 31026505 hsa_circ_005372 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4240 No 31026505 hsa_circ_004112 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4241 No 31026505 hsa_circ_005957 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4242 No 31026505 hsa_circ_005755 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4269 No 31026505 hsa_circ_001764 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4271 No 31026505 hsa_circ_001056 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4223 No 31026505 hsa_circ_002032 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4272 No 31026505 hsa_circ_0000775 CircRNA Homo sapiens Carcinoma, Hepatocellular tumor tissues Regulation(IGF2BP2/CDC27) RNA Pull-Down//ChIP//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//FISH//RIP//DNA Pull-Down//Luciferase Report Assay//Transwell Assay High expression of circ_0000775 in HC cells was induced by transcriptionally stimulation by TCF7L2. Circ_0000775 in cytoplasm recruited IGF2BP2 to enhance the mRNA stability of CDC27, thus positively modulating CDC27 expression. Circ_0000775 exacerbated HC cell migration, invasion and EMT through CDC27. No 35561648 hsa_circ_006763 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6847 No 31026505 hsa_circ_001209 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4292 No 31026505 hsa_circ_004072 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4293 No 31026505 hsa_circ_005452 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4294 No 31026505 hsa_circ_000299 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6846 No 31026505 hsa_circ_0072088 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression(highly expressed) In Vivo Experiment//Western Blot//Transfection//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//IF The screening results showed that circ-0072088 was highly expressed in patients with HCC, and its increase indicated unfavorable prognosis of patients according to quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Moreover, HCC-secreted EXOs mediated the degradation of miR-375 via circ-0072088 and upregulated MMP-16, thus suppressing the metastasis of HCC. Additionally, circ-0072088 was mainly secreted by HCC cells via EXOs in plasma of such patients, and its high level in plasma EXOs was closely associated with tumor node metastasis (TNM) staging and tumor size. No 34568335 hsa_circ_005920 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4295 No 31026505 hsa_circ_000361 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4296 No 31026505 hsa_circ_001444 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4297 No 31026505 hsa_circ_001318 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4298 No 31026505 hsa_circ_005850 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6845 No 31026505 hsa_circ_005504 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4299 No 31026505 hsa_circ_001374 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4300 No 31026505 hsa_circ_005510 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4301 No 31026505 hsa_circ_005821 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4302 No 31026505 hsa_circ_005070 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4303 No 31026505 hsa_circ_004774 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4304 No 31026505 hsa_circ_001657 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4305 No 31026505 hsa_circ_002594 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4306 No 31026505 hsa_circ_005505 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4307 No 31026505 hsa_circ_005156 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6844 No 31026505 hsa_circ_003846 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4308 No 31026505 hsa_circ_005824 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4309 No 31026505 hsa_circ_002416 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6843 No 31026505 hsa_circ_002531 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4310 No 31026505 hsa_circ_004619 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4311 No 31026505 hsa_circ_002701 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4291 No 31026505 hsa_circ_003689 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6848 No 31026505 hsa_circ_005559 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6849 No 31026505 hsa_circ_006496 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4283 No 31026505 hsa_circ_006628 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4273 No 31026505 hsa_circ_002133 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4274 No 31026505 hsa_circ_0079787 CircRNA Homo sapiens Axial Spondyloarthritis blood Expression[lower expressed] qRT-PCR Of the 5 selected circRNAs, the expression of hsa_circ_0079787 was indicated to be significantly reduced in the peripheral blood of patients with AxSpA as compared with the levels in HCs and patients with SLE. No 33000244 hsa_circ_004743 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4275 No 31026505 hsa_circ_000081 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4276 No 31026505 hsa_circ_000987 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4277 No 31026505 hsa_circ_001260 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6857 No 31026505 hsa_circ_001194 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4278 No 31026505 hsa_circ_006247 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4279 No 31026505 hsa_circ_006811 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4280 No 31026505 hsa_circ_000278 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4281 No 31026505 hsa_circ_006666 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4282 No 31026505 hsa_circ_002346 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4284 No 31026505 hsa_circ_003649 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4290 No 31026505 hsa_circ_002340 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6856 No 31026505 hsa_circ_004845 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6855 No 31026505 hsa_circ_002384 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6854 No 31026505 hsa_circ_003800 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4285 No 31026505 hsa_circ_001835 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6853 No 31026505 hsa_circ_001150 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6852 No 31026505 hsa_circ_004130 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4286 No 31026505 hsa_circ_000280 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4287 No 31026505 hsa_circ_000936 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4288 No 31026505 hsa_circ_003939 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4289 No 31026505 hsa_circ_001765 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6851 No 31026505 hsa_circ_004642 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6850 No 31026505 hsa_circ_007236 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4224 No 31026505 hsa_circ_003852 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4222 No 31026505 hsa_circ_101894 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_000455 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Interaction(hsa-miR-22-3p/NLRP3) Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 225 circRNAs were downregulated. No 34024202 hsa_circ_073942 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_006448 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4189 No 31026505 hsa_circ_104078 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_031757 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_001512 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_005285 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4190 No 31026505 hsa_circ_070294 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_005159 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4191 No 31026505 hsa_circ_103916 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_006491 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4192 No 31026505 hsa_circ_004422 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4193 No 31026505 hsa_circ_001366 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4194 No 31026505 hsa_circ_100452 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_101130 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_005526 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4195 No 31026505 hsa_circ_072697 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_000218 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6870 No 31026505 hsa_circ_002032 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_0000116 CircRNA Homo sapiens Azoospermia testicular tissue Expression[highly expressed] qRT-PCR Our study illustrated that the expression of hsa_circ_0000116 was significantly higher in testicular tissue samples of NOA patients than in that of OA patients. No 32735753 hsa_circ_103868 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [highly expressed] Microarray No 34024202 hsa_circ_403471 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [highly expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 229 circRNAs were downregulated. No 34024202 hsa_circ_092488 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [highly expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 228 circRNAs were downregulated.  No 34024202 hsa_circ_017215 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [highly expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 228 circRNAs were downregulated. No 34024202 hsa_circ_101558 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [highly expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 227 circRNAs were downregulated.  No 34024202 hsa_circ_101212 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [highly expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 227 circRNAs were downregulated. No 34024202 hsa_circ_101515 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [highly expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 226 circRNAs were downregulated.  No 34024202 hsa_circ_101209 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [highly expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 226 circRNAs were downregulated. No 34024202 hsa_circ_030050 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_103075 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_406996 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_406775 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_103867 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_007328 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_104935 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_015279 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_000780 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_102558 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_067007 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_103141 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_103161 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_406419 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_406194 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_101053 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_406503 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_005158 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4188 No 31026505 hsa_circ_402150 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_025349 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_406168 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_029998 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_406822 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_402130 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_406267 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_406402 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_001937 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[lower expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_002006 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_001506 CircRNA Homo sapiens Azoospermia Testicular tissue Expression[highly expressed] qRT-PCR//Microarray Using a threshold of fold change (FC) ≥ 1.5 and a p-value < 0.05, we identified 82 differentially expressed circRNAs, of which 16 were up-regulated and 66 were down-regulated in NOA tissues compared with OA tissues (Table 1 and Table 2). No 32029690 hsa_circ_003286 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6871 No 31026505 hsa_circ_071374 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [highly expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 225 circRNAs were downregulated.  No 34024202 hsa_circ_004718 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4196 No 31026505 hsa_circ_006059 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4221 No 31026505 hsa_circ_060056 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [lower expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 224 circRNAs were downregulated.  No 34024202 hsa_circ_0066135 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[lower expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_000156 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6863 No 31026505 hsa_circ_0030979 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[lower expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_002591 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6862 No 31026505 hsa_circ_0087207 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[lower expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_001754 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4209 No 31026505 hsa_circ_0081566 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[lower expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_0015729 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[lower expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_004300 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6861 No 31026505 hsa_circ_001974 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4210 No 31026505 hsa_circ_000303 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4211 No 31026505 hsa_circ_006357 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4212 No 31026505 hsa_circ_002260 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4213 No 31026505 hsa_circ_0026353 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[lower expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_005165 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4214 No 31026505 hsa_circ_0043579 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[lower expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_0020786 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[highly expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_0039985 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[highly expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_000411 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4215 No 31026505 hsa_circ_005235 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4216 No 31026505 hsa_circ_0084859 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[highly expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_001078 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4217 No 31026505 hsa_circ_003288 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4218 No 31026505 hsa_circ_000783 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4219 No 31026505 hsa_circ_002343 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4220 No 31026505 hsa_circ_0046674 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[highly expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_0016628 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[highly expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_005972 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4208 No 31026505 hsa_circ_003490 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6864 No 31026505 hsa_circ_001402 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6865 No 31026505 hsa_circ_000185 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [lower expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 220 circRNAs were downregulated. No 34024202 hsa_circ_406038 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [lower expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 224 circRNAs were downregulated. No 34024202 hsa_circ_006141 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4197 No 31026505 hsa_circ_008289 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [lower expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 223 circRNAs were downregulated.  No 34024202 hsa_circ_103450 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [lower expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 223 circRNAs were downregulated. No 34024202 hsa_circ_005775 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4198 No 31026505 hsa_circ_001525 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4199 No 31026505 hsa_circ_102871 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [lower expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 222 circRNAs were downregulated.  No 34024202 hsa_circ_001719 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4200 No 31026505 hsa_circ_001982 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [lower expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 222 circRNAs were downregulated. No 34024202 hsa_circ_404552 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [lower expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 221 circRNAs were downregulated.  No 34024202 hsa_circ_102746 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [lower expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 221 circRNAs were downregulated. No 34024202 hsa_circ_105009 CircRNA Homo sapiens Venous Thrombosis blood of three DVT patients and three healthy controls Expression [lower expressed] Microarray Here, we found that 303 circRNAs were differentially expressed in deep vein thrombosis using microarray, of which 83 circRNAs were upregulated and 220 circRNAs were downregulated.  No 34024202 hsa_circ_001446 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6869 No 31026505 hsa_circ_003889 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4207 No 31026505 hsa_circ_0054660 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[lower expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_000346 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4201 No 31026505 hsa_circ_002173 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4202 No 31026505 hsa_circ_002827 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4203 No 31026505 hsa_circ_0020068 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[lower expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_002366 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4204 No 31026505 hsa_circ_006929 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6868 No 31026505 hsa_circ_0076808 CircRNA Homo sapiens uterine fibroid ULM tissue Expression[lower expressed] CCK8//qRT-PCR//IF//Microarray The top 10 up and down-regulated circRNAs are listed in Table 3. No 32976932 hsa_circ_006639 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6867 No 31026505 hsa_circ_003700 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6866 No 31026505 hsa_circ_003128 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4205 No 31026505 hsa_circ_006479 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4206 No 31026505 hsa_circ_003607 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6652 No 31026505 hsa_circ_004545 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6651 No 31026505 hsa_circ_004744 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6650 No 31026505 hsa_circ_007255 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6542 No 31026505 hsa_circ_001702 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6541 No 31026505 hsa_circ_000173 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4974 No 31026505 hsa_circ_002089 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4975 No 31026505 hsa_circ_001988 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4976 No 31026505 hsa_circ_001596 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6540 No 31026505 hsa_circ_000162 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4977 No 31026505 hsa_circ_007245 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6539 No 31026505 hsa_circ_006815 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6538 No 31026505 hsa_circ_001082 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6537 No 31026505 hsa_circ_002535 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4978 No 31026505 hsa_circ_004826 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6536 No 31026505 hsa_circ_001083 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6535 No 31026505 hsa_circ_003127 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6534 No 31026505 hsa_circ_006619 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6533 No 31026505 hsa_circ_005812 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6532 No 31026505 hsa_circ_102339 CircRNA Homo sapiens Moyamoya Disease blood Expression[lower expressed] qRT-PCR//Microarray Hsa_circRNA_063411, hsa_circRNA_100146, hsa_circRNA_089761, hsa_circRNA_089762, hsa_circRNA_405463, hsa_circRNA_036592 hsa_circRNA_102534, hsa_circRNA_102339, hsa_circRNA_404457 and hsa_circRNA_405324 were the top ten differentially expressed circRNAs with the highest fold difference, suggesting their potential as candidate biomarkers for MMD No 31132337 hsa_circ_102534 CircRNA Homo sapiens Moyamoya Disease blood Expression[lower expressed] qRT-PCR//Microarray Hsa_circRNA_063411, hsa_circRNA_100146, hsa_circRNA_089761, hsa_circRNA_089762, hsa_circRNA_405463, hsa_circRNA_036592 hsa_circRNA_102534, hsa_circRNA_102339, hsa_circRNA_404457 and hsa_circRNA_405324 were the top ten differentially expressed circRNAs with the highest fold difference, suggesting their potential as candidate biomarkers for MMD No 31132337 hsa_circ_000609 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4979 No 31026505 hsa_circ_002691 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6531 No 31026505 hsa_circ_005012 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4980 No 31026505 hsa_circ_005401 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4981 No 31026505 hsa_circ_000041 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4982 No 31026505 hsa_circ_006782 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4983 No 31026505 hsa_circ_002951 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4984 No 31026505 circHIPK3 CircRNA Homo sapiens Pancreatic Neoplasms PC tumor tissues Expression[highly expressed] qRT-PCR RT-PCR showed that the level of circHIPK3 was increased in PC tumor tissues; moreover, circHIPK3 was also increased in GEM-resistant PC tumors tissues and GEM-resistant PC cells. No 32104074 hsa_circ_006842 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4985 No 31026505 hsa_circ_003750 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4986 No 31026505 hsa_circ_000666 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4973 No 31026505 hsa_circ_001760 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4972 No 31026505 hsa_circ_006549 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4821 No 31026505 hsa_circ_001320 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4971 No 31026505 hsa_circ_006038 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4945 No 31026505 hsa_circ_000270 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4946 No 31026505 hsa_circ_000663 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4947 No 31026505 hsa_circ_005680 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4948 No 31026505 hsa_circ_000810 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4949 No 31026505 hsa_circ_006316 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4950 No 31026505 hsa_circ_003310 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4951 No 31026505 hsa_circ_005887 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4952 No 31026505 hsa_circ_001655 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4953 No 31026505 hsa_circ_005227 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4954 No 31026505 hsa_circ_003230 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4955 No 31026505 hsa_circ_000193 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4956 No 31026505 hsa_circ_004731 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4957 No 31026505 hsa_circ_006371 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4958 No 31026505 hsa_circ_000672 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4959 No 31026505 hsa_circ_005441 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4960 No 31026505 hsa_circ_000555 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4961 No 31026505 hsa_circ_005451 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4962 No 31026505 hsa_circ_000167 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4963 No 31026505 hsa_circ_006056 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4964 No 31026505 hsa_circ_003033 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4965 No 31026505 hsa_circ_002113 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4966 No 31026505 hsa_circ_003726 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6543 No 31026505 hsa_circ_002454 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4967 No 31026505 hsa_circ_005538 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4968 No 31026505 hsa_circ_003227 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4969 No 31026505 hsa_circ_001324 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4970 No 31026505 hsa_circ_006801 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4987 No 31026505 hsa_circ_002783 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4988 No 31026505 hsa_circ_004087 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4989 No 31026505 hsa_circ_004295 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4990 No 31026505 hsa_circ_000135 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6524 No 31026505 hsa_circ_002710 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6523 No 31026505 hsa_circ_036592 CircRNA Homo sapiens Moyamoya Disease blood Expression[highly expressed] qRT-PCR//Microarray Hsa_circRNA_063411, hsa_circRNA_100146, hsa_circRNA_089761, hsa_circRNA_089762, hsa_circRNA_405463, hsa_circRNA_036592 hsa_circRNA_102534, hsa_circRNA_102339, hsa_circRNA_404457 and hsa_circRNA_405324 were the top ten differentially expressed circRNAs with the highest fold difference, suggesting their potential as candidate biomarkers for MMD No 31132337 hsa_circ_005645 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5013 No 31026505 hsa_circ_003048 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5014 No 31026505 hsa_circ_001356 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5015 No 31026505 hsa_circ_405463 CircRNA Homo sapiens Moyamoya Disease blood Expression[highly expressed] qRT-PCR//Microarray Hsa_circRNA_063411, hsa_circRNA_100146, hsa_circRNA_089761, hsa_circRNA_089762, hsa_circRNA_405463, hsa_circRNA_036592 hsa_circRNA_102534, hsa_circRNA_102339, hsa_circRNA_404457 and hsa_circRNA_405324 were the top ten differentially expressed circRNAs with the highest fold difference, suggesting their potential as candidate biomarkers for MMD No 31132337 hsa_circ_004041 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5016 No 31026505 hsa_circ_001522 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5017 No 31026505 hsa_circ_000866 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6522 No 31026505 hsa_circ_001948 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6521 No 31026505 hsa_circ_002627 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6520 No 31026505 hsa_circ_004388 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5018 No 31026505 hsa_circ_001745 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5019 No 31026505 hsa_circ_005587 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5020 No 31026505 hsa_circ_002756 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6519 No 31026505 hsa_circ_005273 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6518 No 31026505 hsa_circ_089762 CircRNA Homo sapiens Moyamoya Disease blood Expression[highly expressed] qRT-PCR//Microarray Hsa_circRNA_063411, hsa_circRNA_100146, hsa_circRNA_089761, hsa_circRNA_089762, hsa_circRNA_405463, hsa_circRNA_036592 hsa_circRNA_102534, hsa_circRNA_102339, hsa_circRNA_404457 and hsa_circRNA_405324 were the top ten differentially expressed circRNAs with the highest fold difference, suggesting their potential as candidate biomarkers for MMD No 31132337 hsa_circ_006029 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6517 No 31026505 hsa_circ_005024 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5021 No 31026505 hsa_circ_003125 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5022 No 31026505 hsa_circ_005431 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5023 No 31026505 hsa_circ_0006220 LncRNA Homo sapiens Pancreatic Neoplasms Exosomal Expression(highly expressed) qRT-PCR//Western Blot Compared with healthy controls, hsa_circ_0006220 and hsa_circ_0001666 were highly expressed in exosomes in the plasma of pancreatic cancer patients. In addition, clinicopathological features revealed that the expression of hsa_circ_0006220 in plasma exosomes from pancreatic cancer patients was associated with CA19-9 levels (p = 0.0001) and lymph node metastasis (p = 0.0005). No 35446993 hsa_circ_089761 CircRNA Homo sapiens Moyamoya Disease blood Expression[highly expressed] qRT-PCR//Microarray Hsa_circRNA_063411, hsa_circRNA_100146, hsa_circRNA_089761, hsa_circRNA_089762, hsa_circRNA_405463, hsa_circRNA_036592 hsa_circRNA_102534, hsa_circRNA_102339, hsa_circRNA_404457 and hsa_circRNA_405324 were the top ten differentially expressed circRNAs with the highest fold difference, suggesting their potential as candidate biomarkers for MMD No 31132337 hsa_circ_001384 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6516 No 31026505 hsa_circ_006740 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6515 No 31026505 hsa_circ_005947 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6514 No 31026505 hsa_circ_000973 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5012 No 31026505 hsa_circ_002238 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6525 No 31026505 hsa_circ_003337 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5011 No 31026505 hsa_circ_001273 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4999 No 31026505 circPDAC RNA CircRNA Homo sapiens Pancreatic Neoplasms PDAC tissues Regulation RNA-seq The novel circRNA, named circPDAC RNA, was not expressed in normal human cells, but was expressed in PDAC and other carcinoma cells. No 32879441 hsa_circ_002405 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6530 No 31026505 hsa_circ_002068 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4991 No 31026505 hsa_circ_0013587 CircRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues, cell lines and plasma samples Expression [highly expressed] qRT-PCR Hsa_circ_0013587 was highly expressed in the pancreatic cancer tissues, cell lines and plasma samples from patients with pancreatic cancer. Notably, hsa_circ_0013587 was upregulated in pancreatic cancer patients with later clinical stages III-IV as compared with those detected in early clinical stages I-II. Notably, hsa_circ_0013587 was upregulated in pancreatic cancer patients with later clinical stages III-IV as compared with those detected in early clinical stages I-II. No 34289738 hsa_circ_005322 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4992 No 31026505 hsa_circ_006283 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4993 No 31026505 hsa_circ_003261 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4994 No 31026505 hsa_circ_005992 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6529 No 31026505 hsa_circ_006367 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4995 No 31026505 hsa_circ_004542 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4996 No 31026505 hsa_circ_006036 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4997 No 31026505 hsa_circ_001834 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4998 No 31026505 hsa_circ_002136 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5000 No 31026505 hsa_circ_005877 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5010 No 31026505 hsa_circ_003657 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5001 No 31026505 hsa_circ_005872 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5002 No 31026505 hsa_circ_004280 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6528 No 31026505 hsa_circ_002884 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6527 No 31026505 hsa_circ_001792 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5003 No 31026505 hsa_circ_005941 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5004 No 31026505 hsa_circ_006253 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5005 No 31026505 hsa_circ_000986 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5006 No 31026505 hsa_circ_003040 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5007 No 31026505 hsa_circ_002919 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5008 No 31026505 hsa_circ_006484 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6526 No 31026505 hsa_circ_004523 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5009 No 31026505 hsa_circ_001737 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4944 No 31026505 hsa_circ_000376 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4943 No 31026505 hsa_circ_000267 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4942 No 31026505 hsa_circ_001961 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4881 No 31026505 hsa_circ_002438 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4853 No 31026505 hsa_circ_007327 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4854 No 31026505 hsa_circ_000398 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4855 No 31026505 hsa_circ_000926 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4856 No 31026505 hsa_circ_004297 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4857 No 31026505 hsa_circ_007040 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4858 No 31026505 hsa_circ_000664 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4859 No 31026505 hsa_circ_002230 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4860 No 31026505 hsa_circ_001712 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4861 No 31026505 hsa_circ_005032 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4862 No 31026505 hsa_circ_003440 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4863 No 31026505 hsa_circ_006472 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4864 No 31026505 hsa_circ_006251 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4865 No 31026505 hsa_circ_003754 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4866 No 31026505 hsa_circ_000786 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4867 No 31026505 hsa_circ_006754 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4868 No 31026505 hsa_circ_001245 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4869 No 31026505 hsa_circ_005325 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4870 No 31026505 hsa_circ_003878 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4871 No 31026505 hsa_circ_002500 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4872 No 31026505 hsa_circ_006991 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4873 No 31026505 hsa_circ_005954 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4874 No 31026505 hsa_circ_006060 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4875 No 31026505 hsa_circ_003472 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4876 No 31026505 hsa_circ_001873 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4877 No 31026505 hsa_circ_002637 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4878 No 31026505 hsa_circ_000108 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4879 No 31026505 hsa_circ_000029 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4852 No 31026505 hsa_circ_002525 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4851 No 31026505 hsa_circ_004799 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4850 No 31026505 hsa_circ_003766 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4835 No 31026505 hsa_circ_006293 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4823 No 31026505 hsa_circ_001791 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4824 No 31026505 hsa_circ_000969 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4825 No 31026505 hsa_circ_005340 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4826 No 31026505 hsa_circ_006781 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4827 No 31026505 hsa_circ_005057 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4828 No 31026505 hsa_circ_000919 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4829 No 31026505 hsa_circ_000551 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4830 No 31026505 hsa_circ_005038 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4831 No 31026505 hsa_circ_006128 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4832 No 31026505 hsa_circ_001759 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4833 No 31026505 hsa_circ_005035 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4834 No 31026505 hsa_circ_001452 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4836 No 31026505 hsa_circ_001998 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4849 No 31026505 hsa_circ_005448 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4837 No 31026505 hsa_circ_006347 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4838 No 31026505 hsa_circ_005550 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4839 No 31026505 hsa_circ_007047 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4840 No 31026505 hsa_circ_004021 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4841 No 31026505 hsa_circ_002660 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4842 No 31026505 hsa_circ_002650 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4843 No 31026505 hsa_circ_002011 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4844 No 31026505 hsa_circ_006647 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4845 No 31026505 hsa_circ_005663 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4846 No 31026505 hsa_circ_002439 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4847 No 31026505 hsa_circ_006403 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4848 No 31026505 hsa_circ_002213 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4880 No 31026505 hsa_circ_004673 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4882 No 31026505 hsa_circ_004475 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4941 No 31026505 hsa_circ_002212 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4883 No 31026505 hsa_circ_007326 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4914 No 31026505 hsa_circ_005551 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4915 No 31026505 hsa_circ_000754 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4916 No 31026505 hsa_circ_002286 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4917 No 31026505 hsa_circ_001927 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4918 No 31026505 hsa_circ_001578 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4919 No 31026505 hsa_circ_000385 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4920 No 31026505 hsa_circ_002123 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4921 No 31026505 hsa_circ_006397 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4922 No 31026505 hsa_circ_005078 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4923 No 31026505 hsa_circ_001658 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4924 No 31026505 hsa_circ_004316 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4925 No 31026505 hsa_circ_003173 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4926 No 31026505 hsa_circ_005399 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4927 No 31026505 hsa_circ_004916 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4928 No 31026505 hsa_circ_007169 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4929 No 31026505 hsa_circ_006136 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4930 No 31026505 hsa_circ_003437 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4931 No 31026505 hsa_circ_000843 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4932 No 31026505 hsa_circ_000785 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4933 No 31026505 hsa_circ_002146 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4934 No 31026505 hsa_circ_006509 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4935 No 31026505 hsa_circ_001000 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4936 No 31026505 hsa_circ_007080 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4937 No 31026505 hsa_circ_002347 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4938 No 31026505 hsa_circ_000670 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4939 No 31026505 hsa_circ_002545 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4940 No 31026505 hsa_circ_002185 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4913 No 31026505 hsa_circ_005595 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4912 No 31026505 hsa_circ_000298 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4911 No 31026505 hsa_circ_004705 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4896 No 31026505 hsa_circ_005844 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4884 No 31026505 hsa_circ_003473 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4885 No 31026505 hsa_circ_005532 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4886 No 31026505 hsa_circ_002375 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4887 No 31026505 hsa_circ_002749 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4888 No 31026505 hsa_circ_006895 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4889 No 31026505 hsa_circ_000515 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4890 No 31026505 hsa_circ_005446 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4891 No 31026505 hsa_circ_003885 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4892 No 31026505 hsa_circ_005174 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4893 No 31026505 hsa_circ_003382 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4894 No 31026505 hsa_circ_000743 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4895 No 31026505 hsa_circ_005533 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4897 No 31026505 hsa_circ_005549 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4910 No 31026505 hsa_circ_004723 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4898 No 31026505 hsa_circ_006001 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4899 No 31026505 hsa_circ_003084 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4900 No 31026505 hsa_circ_003046 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4901 No 31026505 hsa_circ_005541 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4902 No 31026505 hsa_circ_002642 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4903 No 31026505 hsa_circ_004580 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4904 No 31026505 hsa_circ_004698 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4905 No 31026505 hsa_circ_000236 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4906 No 31026505 hsa_circ_000413 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4907 No 31026505 hsa_circ_003435 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4908 No 31026505 hsa_circ_002261 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4909 No 31026505 hsa_circ_100146 CircRNA Homo sapiens Moyamoya Disease blood Expression[highly expressed] qRT-PCR//Microarray Hsa_circRNA_063411, hsa_circRNA_100146, hsa_circRNA_089761, hsa_circRNA_089762, hsa_circRNA_405463, hsa_circRNA_036592 hsa_circRNA_102534, hsa_circRNA_102339, hsa_circRNA_404457 and hsa_circRNA_405324 were the top ten differentially expressed circRNAs with the highest fold difference, suggesting their potential as candidate biomarkers for MMD No 31132337 hsa_circ_0001666 LncRNA Homo sapiens Pancreatic Neoplasms Exosomal Expression(highly expressed) qRT-PCR//Western Blot Compared with healthy controls, hsa_circ_0006220 and hsa_circ_0001666 were highly expressed in exosomes in the plasma of pancreatic cancer patients. The expression of hsa_circ_0001666 was correlated with both tumor size (p = 0.0157) and CA19-9 level (p = 0.0001). No 35446993 hsa_circ_000330 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5024 No 31026505 hsa_circ_005461 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5117 No 31026505 hsa_circ_005430 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5109 No 31026505 hsa_circ_006798 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5110 No 31026505 hsa_circ_007206 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6455 No 31026505 hsa_circ_006909 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6454 No 31026505 hsa_circ_004254 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5111 No 31026505 hsa_circ_0000367 CircRNA Homo sapiens Arthritis, Rheumatoid blood Expression[highly expressed] qRT-PCR The levels of hsa_circ_0002715, hsa_circ_0001947, hsa_circ_0000367, and hsa_circ_0035197 were significantly increased in the peripheral blood of new-onset RA patients than in the peripheral blood of HC. No 31772684 hsa_circ_002873 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5112 No 31026505 hsa_circ_000358 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6453 No 31026505 hsa_circ_0035197 CircRNA Homo sapiens Arthritis, Rheumatoid blood Expression[highly expressed] qRT-PCR The levels of hsa_circ_0002715, hsa_circ_0001947, hsa_circ_0000367, and hsa_circ_0035197 were significantly increased in the peripheral blood of new-onset RA patients than in the peripheral blood of HC. No 31772684 hsa_circ_005369 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6452 No 31026505 hsa_circ_0002715 CircRNA Homo sapiens Arthritis, Rheumatoid blood Expression[highly expressed] qRT-PCR The levels of hsa_circ_0002715, hsa_circ_0001947, hsa_circ_0000367, and hsa_circ_0035197 were significantly increased in the peripheral blood of new-onset RA patients than in the peripheral blood of HC. No 31772684 hsa_circ_004538 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5113 No 31026505 hsa_circ_003135 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6451 No 31026505 hsa_circ_005376 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6450 No 31026505 hsa_circ_006069 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6449 No 31026505 hsa_circ_004082 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6448 No 31026505 hsa_circ_001664 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5114 No 31026505 hsa_circ_004703 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5115 No 31026505 hsa_circ_007019 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6447 No 31026505 hsa_circ_006114 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6446 No 31026505 hsa_circ_002195 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5116 No 31026505 hsa_circ_004968 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6445 No 31026505 hsa_circ_004949 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6444 No 31026505 hsa_circ_005269 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6443 No 31026505 hsa_circ_002063 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6442 No 31026505 hsa_circ_005189 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6441 No 31026505 hsa_circ_005706 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6440 No 31026505 hsa_circ_005704 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5108 No 31026505 hsa_circ_005985 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5107 No 31026505 hsa_circ_003443 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6456 No 31026505 hsa_circ_006440 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6467 No 31026505 hsa_circ_004549 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6475 No 31026505 hsa_circ_005443 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5101 No 31026505 hsa_circ_000066 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6474 No 31026505 hsa_circ_004411 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5102 No 31026505 hsa_circ_006880 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6473 No 31026505 hsa_circ_005576 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6472 No 31026505 hsa_circ_006919 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5103 No 31026505 hsa_circ_001473 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6471 No 31026505 hsa_circ_000888 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5104 No 31026505 hsa_circ_007234 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6470 No 31026505 hsa_circ_003297 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6469 No 31026505 hsa_circ_004787 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6468 No 31026505 hsa_circ_003960 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6466 No 31026505 hsa_circ_006171 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6457 No 31026505 hsa_circ_001874 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6465 No 31026505 hsa_circ_000958 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6464 No 31026505 hsa_circ_006577 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6463 No 31026505 hsa_circ_004506 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6462 No 31026505 hsa_circ_006851 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6461 No 31026505 hsa_circ_002760 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6460 No 31026505 hsa_circ_004266 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5105 No 31026505 hsa_circ_0001715 CircRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissue Expression[highly expressed] qRT-PCR//Microarray Hsa_circ_0001715 was the most up-regulated circRNA in lung adenocarcinoma tissues. We further found that high plasma hsa_circ_0001715 was signi?cantly correlated with TNM stage (P = 0.039) and distant metastasis (P = 0.030). Furthermore, ROC curve analysis showed that hsa_circ_0001715 had high diagnostic value, and the area under the curve (AUC) was 0.871. Lung adenocarcinoma patients with plasma hsa_circ_0001715 levels over 0.417 had significantly shorter OS than those with lower levels (P = 0.004). Univariate and multivariate survival analysis showed that plasma hsa_circ_0001715 level was an independent prognostic factor for the OS. No 33122916 hsa_circ_002851 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5106 No 31026505 hsa_circ_005375 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6459 No 31026505 hsa_circ_005632 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6458 No 31026505 hsa_circ_001089 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6439 No 31026505 hsa_circ_001291 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6438 No 31026505 hsa_circ_001995 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5099 No 31026505 hsa_circ_003967 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5118 No 31026505 hsa_circ_006043 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6428 No 31026505 hsa_circ_006887 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6427 No 31026505 hsa_circ_002466 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5139 No 31026505 hsa_circ_003098 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6426 No 31026505 hsa_circ_006634 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5140 No 31026505 hsa_circ_004097 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6425 No 31026505 hsa_circ_000426 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6424 No 31026505 hsa_circ_001944 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6423 No 31026505 hsa_circ_007014 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6422 No 31026505 hsa_circ_003045 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6421 No 31026505 hsa_circ_005207 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5141 No 31026505 hsa_circ_002312 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5142 No 31026505 hsa_circ_001489 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6420 No 31026505 hsa_circ_004424 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5143 No 31026505 hsa_circ_004108 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5144 No 31026505 hsa_circ_003144 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6419 No 31026505 hsa_circ_004145 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6418 No 31026505 hsa_circ_003970 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5145 No 31026505 hsa_circ_004938 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6417 No 31026505 hsa_circ_006897 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5146 No 31026505 hsa_circ_000012 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5147 No 31026505 hsa_circ_004572 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5148 No 31026505 hsa_circ_004575 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5149 No 31026505 hsa_circ_004134 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5150 No 31026505 hsa_circ_005320 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5151 No 31026505 hsa_circ_002101 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5152 No 31026505 hsa_circ_005836 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5153 No 31026505 hsa_circ_004876 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6429 No 31026505 hsa_circ_000761 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6430 No 31026505 hsa_circ_001358 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6431 No 31026505 hsa_circ_006636 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5125 No 31026505 hsa_circ_003636 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6437 No 31026505 hsa_circ_002541 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5119 No 31026505 hsa_circ_003877 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5120 No 31026505 hsa_circ_003134 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6436 No 31026505 hsa_circ_006096 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6435 No 31026505 hsa_circ_001088 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6434 No 31026505 hsa_circ_007246 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5121 No 31026505 hsa_circ_000017 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5122 No 31026505 hsa_circ_004420 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5123 No 31026505 hsa_circ_001447 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5124 No 31026505 hsa_circ_005081 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6433 No 31026505 hsa_circ_003147 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6432 No 31026505 hsa_circ_002623 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5126 No 31026505 hsa_circ_000324 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5138 No 31026505 hsa_circ_001334 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5127 No 31026505 hsa_circ_000724 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5128 No 31026505 hsa_circ_006593 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5129 No 31026505 hsa_circ_007045 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5130 No 31026505 hsa_circ_003193 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5131 No 31026505 hsa_circ_000735 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5132 No 31026505 hsa_circ_003421 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5133 No 31026505 hsa_circ_005321 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5134 No 31026505 hsa_circ_004620 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5135 No 31026505 hsa_circ_004798 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5136 No 31026505 hsa_circ_000995 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5137 No 31026505 hsa_circ_0005519 CircRNA Homo sapiens Asthma blood Interaction[bind to hsa-let-7a-5p] Luciferase Report Assay//Microarray Hsa_circ_0005519 was up-regulated and negatively correlated with hsa-let-7a-5p expression in CD4 T cells of asthmatic patients.Our data suggest that hsa_circ_0005519 may induce IL-13 and IL-6 expression by regulating hsa-let-7a-5p in CD4 T cells to affect asthma. And hsa_circ_0005519 may be a potential biomarker of asthma. + No 31148290 hsa_circ_000206 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5100 No 31026505 hsa_circ_003759 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5098 No 31026505 hsa_circ_003365 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5025 No 31026505 hsa_circ_001537 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5065 No 31026505 hsa_circ_002496 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5043 No 31026505 hsa_circ_002214 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5044 No 31026505 hsa_circ_002971 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5045 No 31026505 hsa_circ_003282 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6502 No 31026505 hsa_circ_002893 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6501 No 31026505 hsa_circ_006693 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6500 No 31026505 hsa_circ_003731 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6499 No 31026505 hsa_circ_005529 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5046 No 31026505 hsa_circ_002981 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5047 No 31026505 hsa_circ_000844 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5048 No 31026505 hsa_circ_006903 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6498 No 31026505 hsa_circ_002598 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5049 No 31026505 hsa_circ_002310 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5050 No 31026505 hsa_circ_004140 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5051 No 31026505 hsa_circ_001267 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5052 No 31026505 hsa_circ_006215 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5053 No 31026505 hsa_circ_002115 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5054 No 31026505 hsa_circ_000699 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6497 No 31026505 hsa_circ_004734 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5055 No 31026505 hsa_circ_003331 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5056 No 31026505 hsa_circ_001314 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5057 No 31026505 hsa_circ_003985 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5058 No 31026505 hsa_circ_000682 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5059 No 31026505 hsa_circ_005530 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5060 No 31026505 hsa_circ_002858 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5061 No 31026505 hsa_circ_004638 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5062 No 31026505 hsa_circ_000272 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5063 No 31026505 hsa_circ_002065 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6503 No 31026505 hsa_circ_001498 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5042 No 31026505 hsa_circ_001192 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5041 No 31026505 hsa_circ_004390 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5028 No 31026505 hsa_circ_003535 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6513 No 31026505 hsa_circ_063411 CircRNA Homo sapiens Moyamoya Disease blood Expression[lower expressed] qRT-PCR//Microarray Hsa_circRNA_063411, hsa_circRNA_100146, hsa_circRNA_089761, hsa_circRNA_089762, hsa_circRNA_405463, hsa_circRNA_036592 hsa_circRNA_102534, hsa_circRNA_102339, hsa_circRNA_404457 and hsa_circRNA_405324 were the top ten differentially expressed circRNAs with the highest fold difference, suggesting their potential as candidate biomarkers for MMD No 31132337 hsa_circ_003223 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6512 No 31026505 hsa_circ_005388 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6511 No 31026505 hsa_circ_005192 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6510 No 31026505 hsa_circ_005420 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6509 No 31026505 hsa_circ_000776 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5026 No 31026505 hsa_circ_003136 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6508 No 31026505 hsa_circ_003786 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5027 No 31026505 hsa_circ_001184 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6507 No 31026505 hsa_circ_003161 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6506 No 31026505 circHIPK3 CircRNA Homo sapiens Arthritis, Rheumatoid 79 RA patients and 30 control individuals Interaction(microRNA-124a) qRT-PCR//ELISA In all grades of RA groups, there was a significantly substantial elevation of circHIPK3 RNA gene expression, with subsequent downregulation of miRNA-124a when compared to the control group. CircHIPK3 and microRNA-124a expression have been established to be inversely linked. Also, estimation of serum levels of MCP-1, ESR, CRP, and RF exhibited a significant increase in all grades of RA as compared to the control group. No 35291619 hsa_circ_000409 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6505 No 31026505 hsa_circ_005175 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6504 No 31026505 hsa_circ_004389 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5029 No 31026505 hsa_circ_003610 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5030 No 31026505 hsa_circ_007103 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5031 No 31026505 hsa_circ_000455 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5032 No 31026505 hsa_circ_005618 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5033 No 31026505 hsa_circ_003514 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5034 No 31026505 hsa_circ_000561 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5035 No 31026505 hsa_circ_005280 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5036 No 31026505 hsa_circ_005155 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5037 No 31026505 hsa_circ_000454 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5038 No 31026505 hsa_circ_003801 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5039 No 31026505 hsa_circ_000627 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5040 No 31026505 hsa_circ_006540 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5064 No 31026505 hsa_circ_005528 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5066 No 31026505 hsa_circ_0001200 CircRNA Homo sapiens Arthritis, Rheumatoid blood Expression[highly expressed] qRT-PCR//RNA-seq These process closely associated with RA. The basic characteristics of the six circRNAs are listed in -_Table 2. No 32191279 hsa_circ_004040 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5067 No 31026505 hsa_circ_001933 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6485 No 31026505 hsa_circ_007311 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6484 No 31026505 hsa_circ_000384 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5086 No 31026505 hsa_circ_0001402 CircRNA Homo sapiens Arthritis, Rheumatoid blood Expression[lower expressed] qRT-PCR//RNA-seq These process closely associated with RA. The basic characteristics of the six circRNAs are listed in -_Table 2. No 32191279 hsa_circ_004616 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6483 No 31026505 hsa_circ_001841 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5087 No 31026505 hsa_circ_000239 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5088 No 31026505 hsa_circ_0000734 CircRNA Homo sapiens Arthritis, Rheumatoid blood Expression[lower expressed] qRT-PCR//RNA-seq These process closely associated with RA. The basic characteristics of the six circRNAs are listed in -_Table 2. No 32191279 hsa_circ_006563 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6482 No 31026505 hsa_circ_005852 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5089 No 31026505 hsa_circ_006531 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5090 No 31026505 hsa_circ_001359 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5091 No 31026505 hsa_circ_007260 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6481 No 31026505 hsa_circ_0008360 CircRNA Homo sapiens Arthritis, Rheumatoid blood Expression[lower expressed] qRT-PCR//RNA-seq These process closely associated with RA. The basic characteristics of the six circRNAs are listed in -_Table 2. No 32191279 hsa_circ_003347 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6480 No 31026505 hsa_circ_000503 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6479 No 31026505 hsa_circ_000722 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5092 No 31026505 hsa_circ_0003972 CircRNA Homo sapiens Arthritis, Rheumatoid blood Expression[highly expressed] qRT-PCR//RNA-seq These process closely associated with RA. The basic characteristics of the six circRNAs are listed in -_Table 2. No 32191279 hsa_circ_003155 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6478 No 31026505 hsa_circ_003678 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5093 No 31026505 hsa_circ_006530 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5094 No 31026505 hsa_circ_002566 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6477 No 31026505 hsa_circ_001594 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5095 No 31026505 hsa_circ_001678 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5096 No 31026505 hsa_circ_002831 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6476 No 31026505 hsa_circ_007296 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5097 No 31026505 hsa_circ_0001566 CircRNA Homo sapiens Arthritis, Rheumatoid blood Expression[highly expressed] qRT-PCR//RNA-seq These process closely associated with RA. The basic characteristics of the six circRNAs are listed in -_Table 2. No 32191279 hsa_circ_004652 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5085 No 31026505 hsa_circ_006576 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6486 No 31026505 hsa_circ_002129 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6487 No 31026505 hsa_circ_004079 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5077 No 31026505 hsa_circ_004451 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5068 No 31026505 hsa_circ_002193 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6496 No 31026505 hsa_circ_002649 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5069 No 31026505 hsa_circ_002084 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5070 No 31026505 hsa_circ_001220 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6495 No 31026505 hsa_circ_000588 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5071 No 31026505 hsa_circ_004094 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6494 No 31026505 hsa_circ_000339 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5072 No 31026505 hsa_circ_002828 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5073 No 31026505 hsa_circ_006570 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5074 No 31026505 hsa_circ_005298 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5075 No 31026505 hsa_circ_002966 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5076 No 31026505 hsa_circ_002181 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5078 No 31026505 hsa_circ_003618 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5084 No 31026505 hsa_circ_006150 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5079 No 31026505 hsa_circ_001308 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5080 No 31026505 hsa_circ_003780 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5081 No 31026505 hsa_circ_003745 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6493 No 31026505 hsa_circ_006294 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6492 No 31026505 circCRIM1 CircRNA Homo sapiens Adenocarcinoma of Lung LUAC tissues Interaction[microRNA (miR)-182/miR-93-leukemia inhibitory factor receptor pathway] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//RNA-seq Based on circBase data and our biobank tissues, we identified circCRIM1 (a circRNA derived from exons 2, 3 and 4 of the CRIM1 gene, hsa_circ_0002346) as having a significantly decreased expression in LUAC samples compared with matched normal control samples. In the clinical and pathological analyses, the downregulation of circCRIM1 in LUAC was significantly correlated with lymphatic metastasis and TNM stage, which served as an independent risk factor for the overall survival of patients with LUAC. No 31301086 hsa_circ_001579 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6491 No 31026505 hsa_circ_006789 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6490 No 31026505 hsa_circ_000224 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6489 No 31026505 hsa_circ_006317 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6488 No 31026505 hsa_circ_005689 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5082 No 31026505 hsa_circ_003781 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.5083 No 31026505 hsa_circ_005037 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4822 No 31026505 hsa_circ_005582 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4820 No 31026505 hsa_circ_001059 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4508 No 31026505 hsa_circ_006302 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4565 No 31026505 hsa_circ_005470 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6601 No 31026505 hsa_circ_003069 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4566 No 31026505 hsa_circ_004599 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4567 No 31026505 hsa_circ_005178 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6600 No 31026505 hsa_circ_005575 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4568 No 31026505 hsa_circ_005247 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4569 No 31026505 hsa_circ_006748 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4570 No 31026505 hsa_circ_0002571 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[highly expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_0007897 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[highly expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_000799 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4571 No 31026505 hsa_circ_003893 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6599 No 31026505 hsa_circ_003478 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6598 No 31026505 hsa_circ_004465 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4572 No 31026505 hsa_circ_000491 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4573 No 31026505 hsa_circ_001335 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4574 No 31026505 hsa_circ_0007841 CircRNA Homo sapiens Multiple Myeloma cell lines Expression[highly expressed] qRT-PCR The results show that in the MM cell lines and drug-resistant cell lines, hsa_circ_0007841 expression was significantly upregulated, which was closely associated with disease prognosis. No 31803627 hsa_circ_005723 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4575 No 31026505 hsa_circ_005064 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4576 No 31026505 hsa_circ_006417 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4577 No 31026505 hsa_circ_003736 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4578 No 31026505 hsa_circ_006915 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4579 No 31026505 hsa_circ_002409 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4580 No 31026505 hsa_circ_004859 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6597 No 31026505 circMYC CircRNA Homo sapiens Multiple Myeloma serum exosomal Expression[highly expressed] qRT-PCR Compared with healthy people, the expression level of serum exosomal circMYC was significantly increased in patients with MM. No 32812415 hsa_circ_002740 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6596 No 31026505 hsa_circ_003579 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6595 No 31026505 hsa_circ_001732 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6594 No 31026505 hsa_circ_003006 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6602 No 31026505 hsa_circ_000903 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4564 No 31026505 hsa_circ_003177 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4819 No 31026505 hsa_circ_001707 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6603 No 31026505 hsa_circ_006152 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4552 No 31026505 novel_circ_0023209 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 novel_circ_0018621 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_0075830 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[highly expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_005625 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4553 No 31026505 hsa_circ_0002131 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[highly expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_002553 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6610 No 31026505 hsa_circ_000612 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4554 No 31026505 hsa_circ_007005 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6609 No 31026505 hsa_circ_006971 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4555 No 31026505 novel_circ_0002255 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[highly expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_0004712 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[highly expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_001243 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6608 No 31026505 hsa_circ_003210 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6607 No 31026505 hsa_circ_004256 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4556 No 31026505 novel_circ_0022502 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[highly expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_000513 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4557 No 31026505 hsa_circ_004214 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6606 No 31026505 hsa_circ_002999 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4558 No 31026505 hsa_circ_003422 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4559 No 31026505 novel_circ_0000523 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[highly expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_007285 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4560 No 31026505 hsa_circ_007271 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6605 No 31026505 hsa_circ_000325 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4561 No 31026505 hsa_circ_006278 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6604 No 31026505 hsa_circ_001010 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4562 No 31026505 hsa_circ_004028 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4563 No 31026505 hsa_circ_005063 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4581 No 31026505 hsa_circ_005486 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4582 No 31026505 hsa_circ_006463 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4583 No 31026505 hsa_circ_001449 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6593 No 31026505 circKCNQ5 CircRNA Homo sapiens Multiple Myeloma bone marrow plasma cells Expression[highly expressed] qRT-PCR//Microarray In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls. No 31948430 hsa_circ_001044 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4600 No 31026505 hsa_circ_006360 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6585 No 31026505 hsa_circ_006682 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4601 No 31026505 circAFF2 CircRNA Homo sapiens Multiple Myeloma bone marrow plasma cells Expression[lower expressed] qRT-PCR//Microarray In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls. No 31948430 hsa_circ_006197 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4602 No 31026505 hsa_circ_000918 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4603 No 31026505 hsa_circ_000990 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4604 No 31026505 hsa_circ_002996 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4605 No 31026505 hsa_circ_006254 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4606 No 31026505 hsa_circ_001817 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4607 No 31026505 hsa_circ_005519 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4608 No 31026505 hsa_circ_003428 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4609 No 31026505 hsa_circ_000408 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4610 No 31026505 hsa_circ_003139 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6584 No 31026505 hsa_circ_005651 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6583 No 31026505 hsa_circ_005817 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4611 No 31026505 hsa_circ_000827 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4612 No 31026505 hsa_circ_002954 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4613 No 31026505 circWWC3 CircRNA Homo sapiens Multiple Myeloma bone marrow plasma cells Expression[lower expressed] qRT-PCR//Microarray In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls. No 31948430 hsa_circ_002354 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4614 No 31026505 hsa_circ_000570 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4615 No 31026505 hsa_circ_006313 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4616 No 31026505 hsa_circ_000028 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4617 No 31026505 hsa_circ_007199 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4618 No 31026505 hsa_circ_004102 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6582 No 31026505 circDNAJC5 CircRNA Homo sapiens Multiple Myeloma bone marrow plasma cells Expression[lower expressed] qRT-PCR//Microarray In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls. No 31948430 hsa_circ_004109 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4599 No 31026505 hsa_circ_005721 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4598 No 31026505 novel_circ_0012511 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[highly expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_007029 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4590 No 31026505 hsa_circ_002683 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6592 No 31026505 hsa_circ_006732 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4584 No 31026505 hsa_circ_001146 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4585 No 31026505 hsa_circ_0006528 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[highly expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_006375 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6591 No 31026505 hsa_circ_001147 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4586 No 31026505 hsa_circ_005614 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4587 No 31026505 hsa_circ_004739 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4588 No 31026505 hsa_circ_004075 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4589 No 31026505 circPTK2 CircRNA Homo sapiens Multiple Myeloma bone marrow plasma cells Expression[highly expressed] qRT-PCR//Microarray In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls. No 31948430 hsa_circ_005059 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6590 No 31026505 hsa_circ_0067682 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[highly expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_001476 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4591 No 31026505 hsa_circ_003593 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6586 No 31026505 hsa_circ_000870 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4592 No 31026505 hsa_circ_001967 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6589 No 31026505 hsa_circ_001037 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6588 No 31026505 hsa_circ_002878 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4593 No 31026505 hsa_circ_002483 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4594 No 31026505 hsa_circ_003944 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6587 No 31026505 circRNF217 CircRNA Homo sapiens Multiple Myeloma bone marrow plasma cells Expression[highly expressed] qRT-PCR//Microarray In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls. No 31948430 circRERE CircRNA Homo sapiens Multiple Myeloma bone marrow plasma cells Expression[highly expressed] qRT-PCR//Microarray In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls. No 31948430 hsa_circ_002457 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4595 No 31026505 circNAGPA CircRNA Homo sapiens Multiple Myeloma bone marrow plasma cells Expression[highly expressed] qRT-PCR//Microarray In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls. No 31948430 hsa_circ_001361 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4596 No 31026505 hsa_circ_005246 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4597 No 31026505 hsa_circ_002318 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4551 No 31026505 hsa_circ_0008844 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_001926 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4550 No 31026505 circRIMS1‐2 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 circMCU CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 circRIMS1‐1 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_003842 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4518 No 31026505 hsa_circ_000261 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6632 No 31026505 circFLT3‐1 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_006871 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4519 No 31026505 hsa_circ_000715 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4520 No 31026505 hsa_circ_004095 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4521 No 31026505 hsa_circ_001255 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6631 No 31026505 hsa_circ_004179 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6630 No 31026505 circDGKH CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_004622 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4522 No 31026505 circFLT3‐2 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_007095 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4523 No 31026505 circSPHKAP CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 novel_circ_0023024 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 circGRM1 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 circGABRB2 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 novel_circ_0012657 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_006014 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6629 No 31026505 hsa_circ_002672 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4524 No 31026505 hsa_circ_006848 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4525 No 31026505 hsa_circ_001997 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4526 No 31026505 hsa_circ_000204 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4527 No 31026505 hsa_circ_005020 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4528 No 31026505 hsa_circ_004459 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4529 No 31026505 hsa_circ_005469 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4530 No 31026505 hsa_circ_006333 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4517 No 31026505 hsa_circ_003384 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6633 No 31026505 hsa_circ_001700 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6634 No 31026505 hsa_circ_002514 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6643 No 31026505 hsa_circ_001848 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4509 No 31026505 hsa_circ_002548 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6649 No 31026505 hsa_circ_001151 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6648 No 31026505 hsa_circ_000117 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4510 No 31026505 hsa_circ_006957 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4511 No 31026505 hsa_circ_005983 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6647 No 31026505 hsa_circ_006622 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6646 No 31026505 hsa_circ_002503 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4512 No 31026505 hsa_circ_007021 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6645 No 31026505 hsa_circ_002201 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4513 No 31026505 hsa_circ_0071408 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_002336 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6644 No 31026505 hsa_circ_006238 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6642 No 31026505 hsa_circ_002515 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6635 No 31026505 hsa_circ_006495 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4514 No 31026505 hsa_circ_000591 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6641 No 31026505 hsa_circ_006819 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6640 No 31026505 hsa_circ_002243 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6639 No 31026505 hsa_circ_001349 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4515 No 31026505 novel_circ_0018627 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 novel_circ_0003732 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_006383 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6638 No 31026505 hsa_circ_0057123 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_005765 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6637 No 31026505 hsa_circ_005445 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4516 No 31026505 hsa_circ_003555 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6636 No 31026505 circSYNE1 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_005623 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6628 No 31026505 novel_circ_0022200 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 circICA1 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 circCADPS2 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_003976 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4536 No 31026505 hsa_circ_004230 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4537 No 31026505 hsa_circ_003701 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4538 No 31026505 hsa_circ_004634 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4539 No 31026505 hsa_circ_0085173 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_007203 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4540 No 31026505 novel_circ_0023207 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_000255 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6617 No 31026505 hsa_circ_006280 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6616 No 31026505 hsa_circ_005464 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6615 No 31026505 circCAMK4‐1 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_000942 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4541 No 31026505 circCAMK4‐2 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_002448 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4542 No 31026505 hsa_circ_005688 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6614 No 31026505 hsa_circ_000401 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4543 No 31026505 hsa_circ_0006030 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_004659 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6613 No 31026505 hsa_circ_002780 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4544 No 31026505 hsa_circ_004869 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4545 No 31026505 hsa_circ_006055 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4546 No 31026505 hsa_circ_006053 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6612 No 31026505 hsa_circ_002427 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4547 No 31026505 hsa_circ_002497 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4548 No 31026505 hsa_circ_001863 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6611 No 31026505 hsa_circ_001916 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4549 No 31026505 hsa_circ_004740 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6618 No 31026505 hsa_circ_001266 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6619 No 31026505 hsa_circ_000796 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4535 No 31026505 hsa_circ_000211 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4532 No 31026505 novel_circ_0013630 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 hsa_circ_006370 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4531 No 31026505 circGRIK2 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_005359 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6627 No 31026505 hsa_circ_002074 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6626 No 31026505 hsa_circ_0038484 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 circATP8A2 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_005498 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6625 No 31026505 hsa_circ_005583 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6624 No 31026505 hsa_circ_005218 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6623 No 31026505 hsa_circ_006334 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6622 No 31026505 circEPHX2 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 circWAC CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 novel_circ_0001232 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 circTENM1 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_005698 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4533 No 31026505 circSNORD109A CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 circMAP3K5 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_000530 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6621 No 31026505 hsa_circ_002006 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4534 No 31026505 hsa_circ_005948 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6620 No 31026505 circCAMKK2 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 novel_circ_0018629 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 novel_circ_0010653 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 novel_circ_0004306 CircRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[lower expressed] qRT-PCR//RNA-seq A total of 294 circRNAs were detected to be differentially expressed (FC ≥ 2.0 and P adj ≤ 0.05) in ecEM compared with matched euEM samples, with 146 upregulated and 148 downregulated. Hierarchical clustering analysis showed the overview of circRNA expression (Figure ​(Figure1a),1a), and the top 20 up‐ and downregulated circRNAs (Figure ​(Figure1b).1b). Table ​Table22 listed the top 20 up‐ and downregulated circRNAs. No 31144476 circSVEP1 CircRNA Homo sapiens Medulloblastoma medulloblastoma tissues Expression[lower expressed] CCK8//qRT-PCR A total of 33 differentially expressed circRNAs were identified using the volcano plot (fold change ≥2.0 and FDR <0.05) in MB tissues compared with normal cerebellum tissues, including three upregulated and 30 downregulated circRNAs (Figure 3A, Table 1). No 30402980 hsa_circ_002031 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4619 No 31026505 hsa_circ_001348 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4620 No 31026505 hsa_circ_000331 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4621 No 31026505 hsa_circ_003628 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4760 No 31026505 hsa_circ_005487 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4732 No 31026505 hsa_circ_001558 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4733 No 31026505 hsa_circ_002122 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4734 No 31026505 hsa_circ_004672 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4735 No 31026505 hsa_circ_005629 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4736 No 31026505 hsa_circ_005555 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4737 No 31026505 hsa_circ_000813 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4738 No 31026505 hsa_circ_002152 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4739 No 31026505 hsa_circ_000775 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4740 No 31026505 hsa_circ_003515 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4741 No 31026505 hsa_circ_003834 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4742 No 31026505 hsa_circ_004934 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4743 No 31026505 hsa_circ_002712 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4744 No 31026505 hsa_circ_000684 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4745 No 31026505 hsa_circ_006380 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4746 No 31026505 hsa_circ_003735 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4747 No 31026505 hsa_circ_001923 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4748 No 31026505 hsa_circ_003788 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4749 No 31026505 hsa_circ_005129 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4750 No 31026505 hsa_circ_004148 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4751 No 31026505 hsa_circ_002250 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4752 No 31026505 hsa_circ_006899 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4753 No 31026505 hsa_circ_002599 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4754 No 31026505 hsa_circ_003062 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4755 No 31026505 hsa_circ_004244 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4756 No 31026505 hsa_circ_001705 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4757 No 31026505 hsa_circ_002507 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4758 No 31026505 hsa_circ_005979 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4731 No 31026505 hsa_circ_006312 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4730 No 31026505 hsa_circ_001825 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4729 No 31026505 hsa_circ_001553 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4714 No 31026505 hsa_circ_006289 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4702 No 31026505 hsa_circ_001081 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4703 No 31026505 hsa_circ_003666 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4704 No 31026505 hsa_circ_004489 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4705 No 31026505 hsa_circ_000320 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4706 No 31026505 hsa_circ_007177 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4707 No 31026505 hsa_circ_004464 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4708 No 31026505 hsa_circ_000369 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4709 No 31026505 hsa_circ_006290 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4710 No 31026505 hsa_circ_003557 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4711 No 31026505 hsa_circ_000876 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4712 No 31026505 hsa_circ_004055 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4713 No 31026505 hsa_circ_005547 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4715 No 31026505 hsa_circ_001630 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4728 No 31026505 hsa_circ_002207 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4716 No 31026505 hsa_circ_006387 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4717 No 31026505 hsa_circ_001999 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4718 No 31026505 hsa_circ_006552 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4719 No 31026505 hsa_circ_002180 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4720 No 31026505 hsa_circ_000947 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4721 No 31026505 hsa_circ_001345 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4722 No 31026505 hsa_circ_003411 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4723 No 31026505 hsa_circ_002687 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4724 No 31026505 hsa_circ_005427 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4725 No 31026505 hsa_circ_003226 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4726 No 31026505 hsa_circ_001281 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4727 No 31026505 hsa_circ_001224 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4759 No 31026505 hsa_circ_001772 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4761 No 31026505 hsa_circ_003416 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4700 No 31026505 hsa_circ_006813 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4762 No 31026505 hsa_circ_002985 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4793 No 31026505 hsa_circ_002017 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4794 No 31026505 hsa_circ_005876 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4795 No 31026505 hsa_circ_007079 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4796 No 31026505 hsa_circ_003843 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4797 No 31026505 hsa_circ_006288 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4798 No 31026505 hsa_circ_004344 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4799 No 31026505 hsa_circ_007167 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4800 No 31026505 hsa_circ_004522 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4801 No 31026505 hsa_circ_000227 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4802 No 31026505 hsa_circ_005984 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4803 No 31026505 hsa_circ_005656 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4804 No 31026505 hsa_circ_007017 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4805 No 31026505 hsa_circ_003857 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4806 No 31026505 hsa_circ_005468 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4807 No 31026505 hsa_circ_003513 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4808 No 31026505 hsa_circ_003427 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4809 No 31026505 hsa_circ_003378 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4810 No 31026505 hsa_circ_005352 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4811 No 31026505 hsa_circ_000585 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4812 No 31026505 hsa_circ_004482 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4813 No 31026505 hsa_circ_001122 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4814 No 31026505 hsa_circ_002554 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4815 No 31026505 hsa_circ_003049 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4816 No 31026505 hsa_circ_006268 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6544 No 31026505 hsa_circ_003290 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4817 No 31026505 hsa_circ_004290 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4818 No 31026505 hsa_circ_006548 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4792 No 31026505 hsa_circ_006905 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4791 No 31026505 hsa_circ_005531 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4790 No 31026505 hsa_circ_001777 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4775 No 31026505 hsa_circ_002151 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4763 No 31026505 hsa_circ_000583 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4764 No 31026505 hsa_circ_001915 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4765 No 31026505 hsa_circ_006281 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4766 No 31026505 hsa_circ_006188 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4767 No 31026505 hsa_circ_003777 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4768 No 31026505 hsa_circ_003708 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4769 No 31026505 hsa_circ_005150 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4770 No 31026505 hsa_circ_003065 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4771 No 31026505 hsa_circ_002606 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4772 No 31026505 hsa_circ_004783 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4773 No 31026505 hsa_circ_006393 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4774 No 31026505 hsa_circ_002083 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4776 No 31026505 hsa_circ_001121 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4789 No 31026505 hsa_circ_003919 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4777 No 31026505 hsa_circ_006670 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4778 No 31026505 hsa_circ_002509 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4779 No 31026505 hsa_circ_004413 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4780 No 31026505 hsa_circ_000309 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4781 No 31026505 hsa_circ_003918 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4782 No 31026505 hsa_circ_003837 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4783 No 31026505 hsa_circ_001557 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4784 No 31026505 hsa_circ_003239 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4785 No 31026505 hsa_circ_005415 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4786 No 31026505 hsa_circ_002888 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4787 No 31026505 hsa_circ_000964 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4788 No 31026505 hsa_circ_000641 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4701 No 31026505 hsa_circ_001252 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4699 No 31026505 hsa_circ_006077 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4622 No 31026505 hsa_circ_004679 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4659 No 31026505 hsa_circ_005440 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4642 No 31026505 hsa_circ_006379 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4643 No 31026505 hsa_circ_007247 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6574 No 31026505 hsa_circ_002298 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6573 No 31026505 hsa_circ_002461 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4644 No 31026505 hsa_circ_0087776 CircRNA Homo sapiens Multiple Myeloma serum of MM patients Expression [lower expressed] qRT-PCR The results showed that the expression of hsa_circ_0087776 was significantly lower in serum of MM patients (P-value < 0.0001), and the expression was consistent in MM cells. In the analysis of clinicopathological parameters, it was found that there were significant statistical differences with MM stage and renal injury. No 34905439 hsa_circ_005356 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6572 No 31026505 hsa_circ_003325 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6571 No 31026505 hsa_circ_004784 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6570 No 31026505 hsa_circ_003619 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6569 No 31026505 hsa_circ_004757 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6568 No 31026505 hsa_circ_000911 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4645 No 31026505 hsa_circ_000323 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4646 No 31026505 hsa_circ_003698 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4647 No 31026505 hsa_circ_007329 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4648 No 31026505 hsa_circ_006950 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4649 No 31026505 hsa_circ_001981 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4650 No 31026505 hsa_circ_003641 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4651 No 31026505 hsa_circ_005593 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4652 No 31026505 hsa_circ_002428 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4653 No 31026505 hsa_circ_004741 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4654 No 31026505 hsa_circ_003413 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6567 No 31026505 hsa_circ_006541 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4655 No 31026505 hsa_circ_003622 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4656 No 31026505 hsa_circ_003989 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4657 No 31026505 hsa_circ_002398 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6566 No 31026505 hsa_circ_005710 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6565 No 31026505 hsa_circ_005161 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4641 No 31026505 circAL137655 CircRNA Homo sapiens Multiple Myeloma bone marrow plasma cells Expression[lower expressed] qRT-PCR//Microarray In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls. No 31948430 hsa_circ_006460 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4640 No 31026505 hsa_circ_004047 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6580 No 31026505 hsa_circ_0054633 CircRNA Homo sapiens Diabetes Mellitus Serum Expression(lower expressed) qRT-PCR//ELISA Clinical data indicated that serum C peptide was increased in T2D treatment with insulin. Serum hsa_circ_0054633 was decreased in insulin treatment group. Hsa_circ_0054633 was negative correlated with C peptide (r = -0.2841, p = 0.0433,). IL-1 and IL-6, IL-17, and TNF-α were higher in T2D patients and decreased after insulin treatment, only IL-17 and TNF-α showed a positive correlation to hsa_circ_0054633 (r = 0.4825, p < 0.0001, and r = 0.6190, p < 0.0001). The area under ROC curve was 0.7432, 0.5839, and 0.7573 for Hsa_circ_0054633, C peptide, and their combination. No 34272768 hsa_circ_006544 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4623 No 31026505 hsa_circ_007190 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4624 No 31026505 circKLHL2 CircRNA Homo sapiens Multiple Myeloma bone marrow plasma cells Expression[lower expressed] qRT-PCR//Microarray In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls. No 31948430 hsa_circ_004767 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4625 No 31026505 hsa_circ_000706 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4626 No 31026505 hsa_circ_000172 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6581 No 31026505 hsa_circ_003200 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4627 No 31026505 hsa_circ_002171 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4628 No 31026505 hsa_circ_001365 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4629 No 31026505 hsa_circ_006698 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4630 No 31026505 hsa_circ_001852 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4631 No 31026505 hsa_circ_007226 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4632 No 31026505 hsa_circ_003964 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4639 No 31026505 hsa_circ_005815 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4633 No 31026505 hsa_circ_006476 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6579 No 31026505 hsa_circ_004391 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4634 No 31026505 circIQGAP1 CircRNA Homo sapiens Multiple Myeloma bone marrow plasma cells Expression[lower expressed] qRT-PCR//Microarray In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls. No 31948430 hsa_circ_002404 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4635 No 31026505 hsa_circ_002120 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4636 No 31026505 hsa_circ_004607 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6578 No 31026505 hsa_circ_000449 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6577 No 31026505 hsa_circ_005259 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4637 No 31026505 hsa_circ_000518 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6576 No 31026505 hsa_circ_000477 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6575 No 31026505 hsa_circ_001054 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4638 No 31026505 hsa_circ_000188 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4658 No 31026505 hsa_circ_003380 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6564 No 31026505 hsa_circ_004504 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4698 No 31026505 hsa_circ_006153 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4660 No 31026505 hsa_circ_004500 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6551 No 31026505 hsa_circ_005785 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6550 No 31026505 hsa_circ_003953 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4678 No 31026505 hsa_circ_002024 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6549 No 31026505 hsa_circ_003642 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6548 No 31026505 hsa_circ_000826 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4679 No 31026505 hsa_circ_002771 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6547 No 31026505 hsa_circ_000660 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4680 No 31026505 hsa_circ_000917 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4681 No 31026505 hsa_circ_000256 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6546 No 31026505 hsa_circ_001493 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4682 No 31026505 hsa_circ_002393 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4683 No 31026505 hsa_circ_001127 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4684 No 31026505 hsa_circ_005100 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4685 No 31026505 hsa_circ_006800 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4686 No 31026505 hsa_circ_001531 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6545 No 31026505 hsa_circ_005478 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4687 No 31026505 hsa_circ_000306 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4688 No 31026505 hsa_circ_001394 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4689 No 31026505 hsa_circ_001005 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4690 No 31026505 hsa_circ_003489 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4691 No 31026505 hsa_circ_000210 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4692 No 31026505 hsa_circ_006513 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4693 No 31026505 hsa_circ_002290 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4694 No 31026505 hsa_circ_004027 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4695 No 31026505 hsa_circ_002682 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4696 No 31026505 hsa_circ_003965 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4697 No 31026505 hsa_circ_006786 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4677 No 31026505 hsa_circ_002720 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4676 No 31026505 hsa_circ_003890 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4675 No 31026505 hsa_circ_006761 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6561 No 31026505 hsa_circ_002453 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6563 No 31026505 hsa_circ_000765 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4661 No 31026505 hsa_circ_001882 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4662 No 31026505 hsa_circ_001518 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4663 No 31026505 hsa_circ_000003 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4664 No 31026505 hsa_circ_005603 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6562 No 31026505 hsa_circ_005700 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4665 No 31026505 hsa_circ_006858 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4666 No 31026505 hsa_circ_003257 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4667 No 31026505 hsa_circ_006199 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4668 No 31026505 hsa_circ_005599 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4669 No 31026505 hsa_circ_003202 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4670 No 31026505 hsa_circ_006733 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6560 No 31026505 hsa_circ_001549 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4674 No 31026505 hsa_circ_005922 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6559 No 31026505 hsa_circ_003107 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6558 No 31026505 hsa_circ_0006215 CircRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissue Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay RT-qPCR results verified that, in 30 samples of pancreatic cancer tissue and paracancerous tissue, hsa_circ_0006215 expression was increased in pancreatic cancer tissue, miR-378a-3p expression was decreased in pancreatic cancer tissue, and SERPINA4 expression was increased in pancreatic cancer tissue (P<0.05). No 29930719 hsa_circ_001517 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4671 No 31026505 hsa_circ_001274 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4672 No 31026505 hsa_circ_000790 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6557 No 31026505 hsa_circ_001368 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6556 No 31026505 hsa_circ_003668 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6555 No 31026505 hsa_circ_001748 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6554 No 31026505 hsa_circ_001786 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6553 No 31026505 hsa_circ_004255 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.4673 No 31026505 hsa_circ_006788 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[lower expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.6552 No 31026505 hsa_circ_006090 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1714 No 31026505 ZSWIM8-215 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 hsa_circ_001011 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1712 No 31026505 LOC105379018 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1041 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC145474 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC107986416 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 LOC107986108 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 LOC105379395 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 973 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105379254 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 952 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105379251 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 894 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105379232 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 897 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105379140 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1051 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105379132 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 740 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105379131 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 632 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105379088 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1034 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105379080 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 749 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105379068 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 849 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105379067 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 911 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378908 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 612 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101618237 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 934 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378868 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1000 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378821 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 759 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378808 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 843 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378718 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 555 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378698 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 595 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378531 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 797 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378425 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 860 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378409 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 593 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378367 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 649 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378360 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 673 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378344 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1063 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378205 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 609 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378157 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1072 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378095 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1064 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC148696 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC151171 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)69) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 LOC151484 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC154761 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC440434 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC440311 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC440300 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC440173 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC401557 LncRNA Homo sapiens Alzheimer Disease blood Expression[lower expressed] qRT-PCR//Microarray As shown in Fig. 4, compatible with microarray results, expression of lncRNA lnc-AL445989.1-2, TTC39C-AS1, and LINC01420 is significantly high, and lnc-CSTB-1 and LOC401561 are significantly low in the patient group when compared with control groups. No 32885358 LOC401261 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 566 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC400464 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression [differentially expressed] RNA-seq Among the 557 lncRNAs, 30 and 527 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC399815 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC390614 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 922 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC389765 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC388242 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC375196 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LOC374443 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 667 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC349160 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC340512 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC339874 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC339192 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 979 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC338963 LncRNA Homo sapiens Lambert-Eaton myasthenic syndrome three LEMS patients Expression(highly expressed) qRT-PCR Among these, lncRNA LOC338963 and its neighboring mRNA AP3B2 were upregulated jointly, which was confirmed by qRT-PCR. No 35508598 LOC317727 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 763 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC285847 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC285097 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 682 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC285074 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC284344 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC284240 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 715 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC283788 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC283045 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC268276 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 721 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC221946 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC202181 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC105378046 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 648 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105378022 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 695 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377998 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 787 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376577 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1001 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376565 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 746 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376523 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 709 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376427 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 581 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376417 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 554 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376344 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 949 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376278 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 971 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376264 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 699 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376237 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 653 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376214 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 613 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376212 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 553 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376090 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 948 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376075 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 968 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376033 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 772 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376025 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 942 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375972 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC105375971 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1031 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375902 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 635 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375896 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 773 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375895 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 634 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375885 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 696 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375878 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[lower expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 LOC105375844 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 954 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375833 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 552 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375743 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 671 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375655 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 932 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375637 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 614 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375634 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 630 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375608 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 691 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375587 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 933 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376575 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC105376580 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 664 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377988 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 783 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376582 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 588 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377983 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 741 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377972 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 839 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377943 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 927 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377852 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1076 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377836 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 983 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377764 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 900 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377663 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 621 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377632 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 995 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377503 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 681 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377453 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 987 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377398 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 678 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377374 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1045 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377363 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 LOC105377320 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 640 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377319 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 936 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377283 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1055 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377227 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 600 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377225 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 798 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377194 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 901 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377145 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 872 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377053 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 761 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105377016 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 603 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376991 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 822 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376896 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1002 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376838 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 594 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376805 LncRNA Homo sapiens Breast Neoplasms serum of BC patients and healthy subjects Expression [lower expressed] RNA-seq After a comprehensive comparison of the BC patients and healthy subjects, we discovered five up-regulated exo-lncRNAs and six down-regulated exo-lncRNAs of interest. No 34733934 LOC105376744 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 711 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376616 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 985 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105376608 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 867 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC440568 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 596 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC441178 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC441242 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MALAT1 LncRNA Homo sapiens Breast Neoplasms  tumor tissue Expression [highly expressed] qRT-PCR The expression of MALAT1 was more abundant in tumor tissue (2.992 ± 2.256) than that in adjacent normal tissue (1.641±1.438, Z=-2.594, p=0.009), and it was not correlated with any clinical pathological characteristics. No 33519238 MALAT1 LncRNA Homo sapiens Liver Inflammation Caused By Chb In Patients With Chronic Hbv Infection Complicated With Nafld CHB group Interaction(hsa-mir-20b-5p/TXNIP axis ) ChIP Differential analysis of lncRNA shown that the expression of metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) in CHB group was significantly upregulated. It is predicted that there may be a ceRNA regulation relationship of MALAT1/hsa-miR- 20b-5p/TXNIP. No 33775752 MALAT1 LncRNA Homo sapiens Diabetes Mellitus 200 were subjects with T2DM and 200 were healthy subjects Expression(highly expressed) qRT-PCR Compared with healthy controls, patients with T2DM showed an overall increase in expression of lncRNAs NKILA, NEAT, MALAT1, and MIAT by 3.94-fold, 5.28-fold, 4.46-fold, and 6.35-fold, respectively. Higher expression of lncRNA MALAT1 was significantly linked with weight loss (p=0.003), blurred vision (p=0.01), smoking (p<0.0001), and alcoholism (p<0.0001). Higher expression of lncRNA MALAT1 was significantly linked with weight loss (p=0.003), blurred vision (p=0.01), smoking (p<0.0001), and alcoholism (p<0.0001). No 33436407 MALAT1 LncRNA Homo sapiens Medulloblastoma tissues of patients with medulloblastoma Expression(highly expressed) qRT-PCR The expression levels of MALAT1 and SNGH16 were significantly higher in patients with group 3 medulloblastoma than in those with other subtypes. Patients with high expression levels of MALAT1 and SNGH16 had a relatively shorter overall survival than those with low expression levels No 34533098 MALAT1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse Expression(highly expressed) qRT-PCR//IHC MALAT1 expression was further increased in the non-germinal center B-cell-like (non-GCB), advanced stage (stages IIE-IV) and International Prognostic Index (IPI) score (3-5) groups (P = 0.01, P < 0.001 and P < 0.001, respectively). MALAT1 expression was further increased in the non-germinal center B-cell-like (non-GCB), advanced stage (stages IIE-IV) and International Prognostic Index (IPI) score (3-5) groups (P = 0.01, P < 0.001 and P < 0.001, respectively). No 34427833 MALAT1 LncRNA Homo sapiens Ischemic Stroke serum Mutation(G varian) qRT-PCR//Genotyping serum MALAT1 was downregulated, while serum ANRIL was overexpressed in CIS patients, relative to controls. MALAT1 downregulation discriminated CIS patients from controls by receiver-operating-characteristic analysis. Moreover, serum ANRIL denoted good diagnostic accuracy. MALAT1 rs619586 AA and rs3200401 CT, TT were associated with increased CIS risk, whereas ANRIL rs10965215 GG was found to be protective. The studied ANRIL rs10738605 polymorphism was not associated with CIS susceptibility. Notably, the G variant of MALAT1 rs619586 demonstrated a higher serum MALAT1 expression level. Multivariate logistic regression analysis revealed serum MALAT1 as well as MALAT1 rs3200401 CT + TT as independent predictors of CIS. Additionally, a negative association was found between the serum MALAT1 level and the National Institutes of Health Stroke Scale score. In conclusion, MALAT1 rs619586 and rs3200401 and ANRIL rs10965215 are novel prospective noninvasive diagnostic biomarkers for CIS predisposition. serum ANRIL denoted good diagnostic accuracy.Additionally, a negative association was found between the serum MALAT1 level and the National Institutes of Health Stroke Scale score. No 33818067 MALAT1 LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 MALAT1 LncRNA Homo sapiens COVID-19 saliva and nasopharyngeal swab samples Expression(highly expressed) qRT-PCR We evaluated the expression of lncRNAs NEAT1, MALAT1, and MIR3142 in saliva and nasopharyngeal swab from SARS-CoV-2 positive (n = 34) and negative patients (n = 46). A higher expression of the lncRNAs NEAT1 and MALAT1 (p < 0.05) were found in positive samples. NEAT1 had a higher expression mainly in saliva samples (p < 0.001), and MALAT1 was upregulated in nasopharyngeal samples (p < 0.05). Area under the ROC curve for NEAT1 in saliva was 0.8067. This study was the first to investigate the expression of lncRNAs in saliva and nasopharyngeal samples of COVID-19 patients, which gives new insights into the initial response to infection and infectivity and may provide new biomarkers for severity and targets for therapy. No 34463043 MALAT1 LncRNA Homo sapiens COVID-19 peripheral blood mononuclear cells Expression(highly expressed) RNA-seq The immunomodulatory long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 were highly differentially expressed between mild and severe patients in multiple cell types. No 35007307 MALAT1 LncRNA Homo sapiens COVID-19 Peripheral Blood Mononuclear Cell Expression(highly expressed) qRT-PCR The mean expression levels of MALAT-1, THRIL, and miR-155-5p were significantly increased in the acute phase of COVID-19 compared with a healthy control group. In addition, the expression levels of MALAT-1 and THRIL in the post-acute phase of COVID-19 were significantly lower than in the acute phase of COVID-19. According to the ROC curve analysis, these ncRNAs could be considered useful biomarkers for COVID-19 diagnosis and for discriminating between acute and post-acute phase of COVID-19. No 35500644 MALAT1 LncRNA Homo sapiens Diabetic Nephropathies 40 patients with type 2 diabetes and 80 patients with type 2 diabetic kidney disease patients Expression(highly expressed) Other The results showed that MALAT1 and SAA in the diabetic kidney disease with mass albuminuria group were higher than those in the type 2 diabetes mellitus group (q=8.57, P<0.01; q=11.09, P<0.01) and the diabetic kidney disease with microalbuminuria group (q=3.96, P<0.05; q=7.85, P<0.01). No 36536575 MALAT1 LncRNA Homo sapiens Sars-Cov-2 Vaccination Breakthrough Infections 57 VBT and unvaccinated COVID-19 patients Expression(lower expressed) RNA-seq//Bioinformatics Analysis Further, out of the 12 lncRNA genes, 7 lncRNAs are reported to modulate immune/inflammatory responses in infectious diseases. Out of the 7 lncRNAs, LUCAT1, MALAT1, NEAT1 and GAS5 were downregulated in the VBT. LUCAT1 is a negative regulator of interferon response, and downregulation of LUCAT1 suggests an activated interferon response (30). MALAT1 is known to negatively regulate the immune response and positively regulate the inflammatory response in the infected individuals, therefore downregulation of MALAT1 in the breakthrough infection suggests an upregulated immune response and downregulated inflammatory response (31, 32). NEAT1 and GAS5 also act as pro-inflammatory lncRNAs, and their downregulation is an indicator of decreased inflammatory response in the VBT (33, 34). Amongst the upregulated lncRNAs, ROR1-AS1, UGDH-AS1 and LINC00273 were upregulated in the VBT. The upregulation of ROR1-AS1 and LINC00273 indicates a heightened immune response, whereas upregulation of UGDH-AS1 suggests a decreased disease severity possibly modulated by MOV10 and EDN1 (8). No 36466827 MALAT1 LncRNA Homo sapiens Coronary Artery Disease CAD patients Expression(highly expressed) qPCR MALAT1 and MIAT were upregulated in CAD patients (p Value= .0008 and .0078, respectively). The expression level of XIST was significantly elevated diabetic compared to non-diabetic CAD patients (p Value= .0003). MALAT1 gene had the highest diagnostic power for discrimination of CAD patients from controls (AUC= 0.682, p Value=.001). No 32447981 MALAT1 LncRNA Homo sapiens Growth Hormone-Secreting Pituitary Adenoma Expression [highly expressed] qRT-PCR Our results revealed that the expression of lncRNA H19 was remarkably higher in invasive GHPAs, however, there was no significant differences between the expression of lncRNA MALAT-1 in invasive GHPAs and non-invasive GHPAs, suggesting that lncRNA H19 may play an important role in GHPA invasion. LncRNA H19 might be a target for the study of GHPAs invasion, and a potential index for the diagnosis or prognosis of GHPAs. No 29604339 Malat1 LncRNA Mus musculus acute myocardial infarction myocardial tissues Regulation[ miR-320-Pten axis] qRT-PCR//Luciferase Report Assay//Tunel//Western Blot MALAT1 and Pten were highly expressed, while miR-320 was suppressed in MI group. Mechanistically, MALAT1 may serve as a sponge for miR-320 to upregulate Pten, a direct target of miR-320. No 29990866 Malat1 LncRNA Mus musculus Diabetic Nephropathies renal tissues Regulation[miR-145/ZEB2 axis] qRT-PCR//Luciferase Report Assay//Western Blot MALAT1 was upregulated while miR-145 was downregulated in renal tissues of db/db mice. Mechanistically, MALAT1 functions as a sponge RNA for miR-145 to derepress the expression of target gene ZEB2, thereby inducing EMT and fibrosis. These results provide a novel potential target for DN therapy in the future. No 31081103 Malat1 LncRNA Mus musculus Renal Ischemia/Reperfusion Injury kidney tissues Expression[highly expressed] qPCR//Western Blot//Microarray We identified that renal IRI induced the upregulation of SPRR2F, SPRR1A, MMP-10, and long noncoding RNA (lncRNA) Malat1 in kidney tissues for 479.3-, 4.98-, 238.1-, and 3.79-fold, respectively. No 30668132 Malat1 LncRNA Mus musculus Osteoporosis Femoral tissues Regulation[MAPK signaling pathway] Flow Cytometry//qPCR//Western Blot The results of qPCR showed that the expression of lncRNA MALAT1 in OP rats was significantly lower than that of normal rats.Moreover, it inhibited osteogenic differentiation of BMSCs by enhancing the activation of the MAPK signaling pathway, thereby promoting OP progression. No 31210287 MALAT1 LncRNA Rattus norvegicus Cerebral Hemorrhage ICH rats. Regulation(p-p65/p65) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//ELISA First, we found that MALAT1 was expressed at higher levels in ICH rats. miR-146a is a target gene of MALAT1 and is downregulated in ICH rats. Downregulation of MALAT1 inhibited the neurological scores, brain water content, and neuronal apoptosis, reduced the levels of pro-inflammatory cytokines, and prevented oxidative stress in ICH rats. In addition, the protein level of p-p65 and the ratio of p-p65/p65 were decreased in the MALAT1-shRNA group. No 35113000 MAGOHB LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MAGI2-AS3 LncRNA Homo sapiens Breast Neoplasms "cell lines (MDA-MB-231 36 and MCF-7)" Interaction[microRNA-374a ] qRT-PCR//Luciferase Report Assay//Western Blot In addition, an increase in MAGI2-AS3 can inhibit microRNA-374a (miR-374a) expression in breast cancer cells. Bioinformatic analysis predicted the correlation between MAGI2-AS3 and miR-374a. Phosphatase and tensin homolog (PTEN) was found to be an novel mRNA target of miR-374a. MAGI2-AS3 upregulation inhibited breast cancer metastatic progression by decreasing miR-374a and enhancing PTEN expression. No 30883342 MAGI2-AS3 LncRNA Homo sapiens Glioma glioma tissues Expression[lower expressed] qRT-PCR We found that the relative expression level of MAGI2-AS3 in glioma tissues was significantly lower than those in adjacent normal brain tissues (p<0.01). Lower MAGI2-AS3 expression was observed to be positively correlated with the World Health Organization (WHO) grade (p=0.031) and KPS score (p=0.003) in glioma patients. The Kaplan-Meier analysis indicated that patients with low MAGI2-AS3 expression levels tended to have worse overall survival than those with high levels of MAGI2-AS3 expression (p=0.0042). No 31081100 MAGI2-AS3 LncRNA Homo sapiens Intervertebral Disc Degeneration plasma Expression[lower expressed] qRT-PCR//Western Blot The expression levels of plasma lncRNA MAGI2-AS3 were lower in IDD patients compared to that in the control group. No 32143617 MAGI2-AS3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miRNA-374-5p/FOXO1) Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Transwell Assay CeRNAs of the lncRNA MAGI2-AS3/miR-374-5p/FOXO1 pathway were significantly dysregulated in HCC, and validation in vitro showed that FOXO1 is positively regulated by MAGI2-AS3 through the induction of miR-374a/b-5p in HCC cells. No 36359865 MAGI2-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MAGI1-IT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MAFIP LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 MAFG‐AS1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)106) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 MAFA-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung TCGA(LUAD cancer and normal samples) Regulation Survival Analysis Herein, we identified an eight-lncRNA signature (PR-lncRNA signature, NPSR1-AS1, SATB2-AS1, LINC01090, FGF12-AS2, AC005256.1, MAFA-AS1, BFSP2-AS1, and CPC5-AS1), which contributes to predicting LUAD patient's prognosis risk and survival outcomes. Of them, NPSR1-AS1, SATB2-AS1, FGF12-AS2, and AC005256.1 could be acted as the poor prognosis markers, while LINC01090, MAFA-AS1, BFSP2-AS1, and CPC5-AS1 were treated as the protective factors for survival in LUAD patients. No 34550610 MALAT1 LncRNA Homo sapiens Acute Kidney Injury kidney injury specimens and NRK-52E cells Interaction(miR-146a/NF-κB signaling pathway) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Cell Proliferation Assay The expression levels of miR-146a were lower in the kidney injury specimens and NRK-52E cells, compared with those in the controls. MALAT1 knockdown and the overexpression of miR-146a reduced the production of phosphorylated inhibitor of NF-κB and np65 protein. miR?146a was found to be transcriptionally induced by NF-κB, and miR-146a repressed the pro-inflammatory NF-κB pathway and downstream transcription factors. Taken together, these data indicated that the MALAT1/miR?146a/NF-κB pathway exerted key functions in LPS-induced AKI, and provided novel insights into the mechanisms of this therapeutic candidate for the treatment of the disease. No 29115409 MALAT1 LncRNA Homo sapiens acute myeloid leukemia AML patients Regulation(EZH2/SUZ12/H3K27 ) qRT-PCR//Transfection//Western Blot MALAT-1, EZH2 and EED gene expression was markedly increased in AML patients with E-cadherin down-regulation. A positive correlation between EZH2 or SUZ12 and MALAT-1 expression was observed. No 35747989 MACC1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[MACC1-AS1/miR-145 axis] qRT-PCR//RNA Pull-Down//Luciferase Report Assay MACC1-AS1 was highly expressed in HCC tissues and cells. This work revealed a novel MACC1-AS1/miR-145 axis that regulates the stemness of HCC cells. No 32339066 MALAT1 LncRNA Homo sapiens Bronchopulmonary Dysplasia BPD premature infants Interaction(Keap1/Nrf2 signal pathway) qRT-PCR//Transfection//Cell Apoptosis Assay//Western Blot The results showed that, compared to the control group, the expression of MALAT1 increased significantly, and AIF decreased substantially in BPD premature infants. In the A549 hyperoxic lung injury model, compared with the air group, the expression of MALAT1 in the hyperoxia group decreased markedly, while the expression of Keap1 and Nrf2 increased considerably. Furthermore, compared with the control plasmid transfection air group (NC group), the expression of Keap1 and Nrf2 increased significantly in the small interfering RNA (siRNA) group. No 33708512 MALAT1 LncRNA Homo sapiens Diabetic Nephropathies micro-albuinuria diabetic group Expression(highly expressed) qRT-PCR MALAT1 expression, serum caspase1 level, IL18 level, myeloperoxidase activity, and protein carbonyl level were significantly increased in micro-albuinuria diabetic group when compared with diabetic normo-albuminuria group. No 36270460 MALAT1 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR Plasma lncRNA MALAT1 expression was elevated in sepsis patients than HCs (P < 0.001), and ROC curve disclosed that it had a good value in predicting sepsis risk with an area under curve (AUC) of 0.823 (95% CI: 0.783-0.864). Additionally, lncRNA MALAT1 expression was positively correlated with Scr (P = 0.005), WBC (P = 0.017), CRP (P < 0.001), PCT (P < 0.001), TNF-α (P < 0.001), IL-8 (P < 0.001), IL-17 (P = 0.001), APACHE II score (P < 0.001), and SOFA score (P < 0.001). LncRNA MALA1 expression was elevated in deaths compared with survivors (P < 0.001) and could predict the risk of 28-day mortality with an AUC of 0.755 (95% CI: 0.682-0.828). Accumulating survival was worse in patients with lncRNA MALAT1 high expression compared with patients who had lncRNA MALAT1 low expression (P < 0.001). No 31301104 MALAT1 LncRNA Homo sapiens Sepsis cell lines Regulation[miR-150-5p/NF-κB axis] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay MALAT1 was highly expressed, but miR-150-5p was downregulated in LPS-mediated H9c2 cells.We first demonstrated that MALAT1 depletion is responsible for the sepsis inflammatory response by inhibiting the expressions of IL-6 and TNF-α and the NF-κB signaling pathway by upregulating miR-150-5p. No 31934174 MALAT1 LncRNA Homo sapiens Sepsis Blood Expression[highly expressed] qRT-PCR Lnc-MALAT1/miR-125a axis was increased in sepsis patients compared with healthy controls (P < .001) and was of excellent value in distinguishing septic patients from healthy controls with the area under the curve (AUC) of 0.931 (95% CI: 0.908-0.954). No 32309886 MALAT1 LncRNA Homo sapiens Endometriosis Endometriosis tissue Expression[highly expressed] qRT-PCR//MTT//IHC//Western Blot In the present study, we found that both lncRNA-MALAT1 and autophagy level were up-regulated in ectopic endometrium from patients with endometriosis, and its expression level correlates positively with that of hypoxia-inducible factor-1α (HIF-1α). No 30324652 MALAT1 LncRNA Homo sapiens Abortion, Habitual blood Mutation[rs619586 ] Genotyping Our results showed that the rs619586 G variant had protective effects against recurrent miscarriage (AG vs. AA: adjusted OR = 0.670, 95% CI = 0.457-0.982, p = 0.040; GG vs. AA: adjusted OR = 0.278, 95% CI = 0.079-0.975, p = 0.046; GG/AG vs. AA adjusted OR = 0.621, 95% CI = 0.429-0.900, p = 0.012). In a combined analyses of protective genotypes, with regard to the three single nucleotide polymorphisms (SNPs), we found that individuals with two or three protective genotypes exhibited a significantly lower risk of recurrent miscarriage than those with no or only one protective genotype (adjusted OR = 0.369, 95% CI = 0.199-0.684, p = 0.002). Moreover, the decrease in recurrent miscarriage risk with two or three protective genotypes was most pronounced in women less than 35 years of age (OR = 0.290, 95% CI = 0.142-0.589, p < 0.001) and in women with 2-3 miscarriages (adjusted OR = 0.270, 95% CI = 0.126-0.580, p < 0.001). In conclusion, our study suggests that the rs619586 G variant may have potential protective effects conferring a decreased risk of recurrent miscarriage in the southern Chinese population. No 31024342 MALAT1 LncRNA Homo sapiens Abortion, Habitual blood Regulation[p53-MALAT1 pathway] qRT-PCR//Luciferase Report Assay We found the level of NEAT1 and MALAT1 was reduced significantly and only the MALAT1 level negatively correlated with p53 protein level. No 30848022 MALAT1 LncRNA Homo sapiens Arthritis, Rheumatoid blood Expression[highly expressed] qRT-PCR MALAT1, MEG3, NEAT1 were increased in PBMCs, plasma, synovial fluid (p < 0.05) of RA patients. No 33026292 MALAT1 LncRNA Homo sapiens Arthritis, Rheumatoid peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR The expression levels of NR_002819, NR_038935, and ENST00000603415 were significantly increased in the RA-ILD group, while the expression level of ENST00000560199 was significantly decreased. No 32133566 MALAT1 LncRNA Homo sapiens Gastrointestinal Neoplasms Expression[highly expressed] Meta-analysis A total of ten studies reported the OS of 1,052 patients, according to MALAT1 expression levels. Heterogeneity analysis revealed no heterogeneity among these studies, therefore, the fixed-effects model (I2, 0.0%; P=0.528) was assessed in the meta-analysis. Overall, the pooled results confirmed a significant association between high MALAT1 expression and poor OS in digestive system malignancies, with a HR value of 1.62 (95% CI, 1.35–1.88; P<0.001; Fig. 2). Although there was no significant heterogeneity among the studies, a subgroup meta-analysis was conducted on tumor type, country, sample size and analysis type (Table III). A significant association was identified between the expression of MALAT1 and the OS of patients with digestive system malignant tumors in China (HR, 1.63; 95% CI, 1.34–1.91). The association between MALAT1 and OS was significant in studies with a sample size ≥100 (HR, 1.57; 95% CI, 1.27–1.88; P<0.001) and <100 (HR, 1.76; 95% CI, 1.21–2.31; P<0.001). Furthermore, MALAT1 was also identified to be significantly associated with OS of patients in studies with multivariate analysis (HR, 1.51; 95% CI, 1.19–1.84; P<0.001) and non-multivariate analysis (HR, 1.84; 95% CI, 1.37–2.31; P<0.001). Furthermore, sensitivity analysis indicated the robustness of the meta-analysis results (Fig. 3). No 30719108 MALAT1 LncRNA Homo sapiens clear cell renal cell carcinoma KIRC tissues,cell lines Interaction[miR-194-5p/ACVR2B signaling] CCK8//Luciferase Report Assay//Colony Formation Assay//Flow Cytometry The results showed that highly expressed MALAT1, ACVR2B, and lowly expressed miR-194-5p were associated with larger tumor size (≥4 cm), advanced TNM stage and poor prognosis of KIRC patients, when, respectively, compared with lowly expressed MALAT1, ACVR2B, and highly expressed miR-194-5p (P < 0.05). Transfection of pcDNA-MALAT1, miR-194-5p inhibitor, and pcDNA-ACVR2B conferred the KIRC cells with promoted viability and proliferation, as well as reduced apoptosis (P < 0.05). Treatment of rats with pcDNA-MALAT1, miR-194-5p inhibitor, or pcDNA-ACVR2B also contributed to larger tumor size growing in them (P < 0.05). Moreover, MALAT1 could directly target miR-194-5p to suppress its expression, and ACVR2B was the targeted molecule of miR-194-5p (P < 0.05). Finally, ACVR2B could reverse the effects exerted by miR-194-5p on viability, proliferation, and apoptosis of KIRC cells (P < 0.05). In conclusion, LncRNA MALAT1/miR-194-5p/ACVR2B signaling was regarded as a candidate pathway for modulating KIRC progression. The results showed that highly expressed MALAT1, ACVR2B, and lowly expressed miR-194-5p were associated with larger tumor size (≥4 cm), advanced TNM stage and poor prognosis of KIRC patients, when, respectively, compared with lowly expressed MALAT1, ACVR2B, and highly expressed miR-194-5p (P < 0.05). No 30334578 MALAT1 LncRNA Homo sapiens Glaucoma blood Expression[lower expressed] qRT-PCR Compared with those in the control group, patients in the study group had significantly lower expression of serum lncRNA MALAT1 and lncRNA ANRIL (P<0.05), significantly lower expression of serum PEDF and IL-12 (P<0.05), and significantly higher expression of serum Hcy and IL-4 (P<0.05), without significant difference in the expression of serum IFN-γ between the two groups (P>0.05). No 32010306 MALAT1 LncRNA Homo sapiens Glaucoma Three hundred and forty-six glaucoma patients and 263 healthy controls Mutation(rs619586, rs3200401, rs664589 ) Genotyping The MALAT1 SNPs rs619586 (A>G), rs3200401 (C>T), and rs664589 (C>G) were associated with POAG risk, and the ANRIL SNPs rs2383207 (A>G), rs564398 (A>G), rs2157719 (A>G), rs7865618 (G>A), and rs4977574 (A>G) were associated with POAG (p < 0.05). The MALAT1 haplotypes ACG and ATC, comprised rs619586, rs3200401, and rs664589, increased POAG risk, and the ANRIL haplotype AAGAA, made up of rs2383207, rs7865618, rs4977574, rs564398, and rs2157719, show a significantly increased risk of POAG. In addition, rs619586 (A>G) of MALAT1 and rs564398/rs2157719 of ANRIL were associated with a smaller vertical cup-to-disc ratio, while rs619586 of MALAT1 and rs2383207/rs4977574 of ANRIL were associated with higher intraocular pressure in the POAG population. No 35028972 MALAT1 LncRNA Homo sapiens Non-alcoholic Fatty Liver Disease hepatocytes Interaction(miR-206/ARNT Axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//H&E Staining//Oil Red O Staining//IHC//Bioinformatics Analysis//ChIP The data revealed expression of MALAT1 was up-regulated in vitro and in vivo in NAFLD, and knockdown of MALAT1 suppressed FFA-induced lipid accumulation in hepatocytes. Meanwhile, MALAT1 upregulated the expression of ARNT through binding with miR-206. Moreover, miR-206 inhibitor reversed MALAT1 knockdown effects in decreased lipid accumulation in FFA-treated hepatocytes. Furthermore, ARNT could inhibit the expression of PPARα via binding with PPARα promoter. Knockdown of MALAT1 significantly upregulated the level of PPARα and downregulated the expression of CD36, while PPARα knockdown reversed these phenomena. MALAT1 regulated PPARα/CD36 -mediated hepatic lipid accumulation in NAFLD through regulation of miR-206/ARNT axis. No 35769097 MALAT1 LncRNA Homo sapiens Mycosis Fungoides MF tissues Interaction[CCL21 ] Transwell Assay//Western Blot Expression of MALAT1 was selectively increased in MF tissues. C-C Chemokine receptor type 7 (CCR7) expression was found to be increased in MyLa cells. CCL21 was found not only to mediate migration, but also to enhance MALAT1 and mammalian target of rapamycin (mTOR) activation in MyLa cells. Knockdown of MALAT1 abrogated CCL21-mediated migration, but not mTOR activation. In contrast, mTOR inhibition reduced CCL21-mediated migration and MALAT1 expression. No 31028199 MALAT1 LncRNA Homo sapiens Brain Injuries brain tissues Expression[highly expressed] qRT-PCR//Luciferase Report Assay//Tunel//Western Blot MALAT1 and WNT1 were high-expressed in brain tissues of HIBD mice while miR-429 was low-expressed in brain tissues from HIBD mice. No 31185248 MALAT1 LncRNA Homo sapiens Psoriasis Iranian patients Mutation(rs619586, rs3200401) Genotyping We investigated the associations between two genetic variants in MALAT1 and susceptibility to psoriasis in the Iranian population. The G allele of rs619586 has been shown to be less common among cases versus controls (odds ratios (OR; 95% confidence intervals (CI)) = 0.57 (0.36-0.9)), adjusted p = .02). This single nucleotide polymorphism has been associated with the risk of psoriasis in a dominant model (AG + GG vs. AA: OR (95% CI) = 0.56 (0.35-0.92), adjusted p = .04) as well as log-additive model (OR (95% CI) = 0.59 (0.38-0.92), adjusted p = .04). The rs3200401 was not associated with psoriasis in any of the supposed inheritance models. This study potentiates rs619586 as a risk locus for psoriasis in the Iranian population No 34846099 MALAT1 LncRNA Homo sapiens Coronary Artery Disease Epigenetics [rs619586, rs11227209 , rs3200401 ] Genotyping The rs619586 AG/GG genotypes and G allele were associated with a reduced risk of CAD (AG/GG vs. AA: adjusted OR = 0.66, 95% CI: 0.48-0.91; G vs. A: adjusted OR = 0.68, 95% CI: 0.51-0.90). Stratification analyses showed that CAD patients with rs11227209 CG/GG, rs619586 AG/GG, and rs3200401 CT/TT genotypes exhibited lower levels of TCH (P = 0.02, 0.04, and 0.02, respectively). Moreover, CGCC haplotype was associated with a decreased risk of CAD (OR = 0.28, 95% CI: 0.16-0.48). Multivariate logistic regression analysis identified some independent risk factors for CAD, including rs619586 and rs664589. Subsequent combined analysis showed that the combined genotypes of rs619586AG/GG and rs664589CC were associated with a reduced risk of CAD (OR = 0.29; 95%CI, 0.16-0.53). No 29631611 MALAT1 LncRNA Homo sapiens Cerebral Infarction blood Interaction[downregulated the expression of hsa-miR-145-5p, hsa-miR-140-5p, hsa-miR-483-3p, and hsa-miR-338-3p] qRT-PCR//Western Blot The levels of hsa-miR-145-5p, hsa-miR-140-5p, hsa-miR-483-3p, and hsa-miR-338-3p in the plasma of ACI patients were significantly lower than those in the control group (p < 0.001), and the plasma LncRNA MALAT1 levels were significantly higher in ACI patients than in the control group (p < 0.001). The level of LncRNA MALAT1 in plasma of ACI patients and control group was negatively correlated with hsa-miR-145-5p, hsa-miR-140-5p, hsa-miR-483-3p, and hsa-miR-338-3p (r = - 0.36, - 0.79, - 0.76, - 0.75; - 0.60, - 0.68, - 0.48, - 0.56). Plasma levels of hsa-miR-145-5p, hsa-miR-140-5p, hsa-miR-483-3p, and hsa-miR-338-3p were negatively correlated with hs-CRP levels in patients with ACI and controls (r = - 0.74, - 0.81, - 0.84, - 0.56; - 0.61, - 0.69, - 0.69, - 0.50). MALAT1 transfection resulted in the decreased levels of hsa-miR-145-5p, hsa-miR-140-5p, hsa-miR-483-3p, and hsa-miR-338-3p in HUVECs while overexpression of hsa-miR-145-5p, hsa-miR-140-5p, hsa-miR-483-3p, and hsa-miR-338-3p led to a decrease in hs-CRP levels in HUVECs. LncRNA MALAT1 induced the upregulation of CRP expression through inhibiting the expression of hsa-miR-145-5p, hsa-miR-140-5p, hsa-miR-483-3p, and hsa-miR-338-3p. No 31342266 MALAT1 LncRNA Homo sapiens gastric adenocarcinoma GA tissues Expression[differently expression] qRT-PCR//Microarray The expression of 5 differentially expressed lncRNAs, HNF1A-AS1, RP11-62F24.2, GAS5, MALAT1, and H19 were randomly selected to be measured in 47 patients using real-time quantitative reverse transcription PCR (qRT-PCR), and the data were consistent with those obtained from the microarray chip. No 31850717 MALAT1 LncRNA Homo sapiens beta-Thalassemia blood Expression[highly expressed] qRT-PCR Significant higher expression levels of the studied lncRNAs in β-thal patients compared to the controls (all P values < 0.001) were identified. No 30665334 MALAT1 LncRNA Homo sapiens Myasthenia Gravis blood Interaction[sponging miR-338-3p ] qRT-PCR//Luciferase Report Assay//Western Blot In this study, we found that MALAT-1 expression was downregulated in MG. Thus, MALAT-1 directly induced MSL2 expression in MG by acting as a competing endogenous RNA for miR-338-3p, suggesting that it may serve as a therapeutic target for MG treatment. No 30362606 MALAT1 LncRNA Homo sapiens Diabetic Nephropathies blood Expression[lower expressed] qRT-PCR LncRNA MALAT1 expression in peripheral blood mononuclear cells (PBMC) was significantly upregulated in T2DM and DKD groups when compared to control. No 32832561 MALAT1 LncRNA Homo sapiens Coronary Disease  plasma Expression [highly expressed] qRT-PCR Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 relative expression was increased, but miR-125b relative expression was decreased in CHD patients compared with controls. ROC curve exhibited that lncRNA MALAT1 and miR-125b were of good value in differentiating CHD patients from controls, and further logistic regression analysis verified their independent correlation with CHD risk. In CHD patients, lncRNA MALAT1 was positively correlated with Gensini score, total cholesterol, low-density lipoprotein cholesterol, C-reactive protein, tumor necrosis factor α, interleukin (IL)-1β, IL-6, IL-17, and accumulating MACE occurrence; reversely, miR-125b presented a opposite trend. No 33660877 MALAT1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues regulation[miR-202 ] qRT-PCR Comparison of different lncRNAs in tumor samples from osteosarcoma with and without lung metastasis led to identification of MALAT1 as the most differentially upregulated lncRNA in the osteosarcoma patients with lung metastasis.In conclusion, MALAT1-miR-202 represents a potential lncRNA-miRNA signature that affects lung metastasis of osteosarcomas and could potentially be targeted for therapy. No 32728178 MALAT1 LncRNA Homo sapiens Lupus Erythematosus, Discoid 163 SLE patients Mutation(rs3200401 ) Genotyping We aimed to explore the contribution of HOTAIR (rs10783618), LINC-ROR (rs1942347), and MALAT1 (rs3200401) variants to SLE susceptibility and/or severity in 163 SLE patients and age-/sex-matched controls using real-time TaqMan allelic discrimination PCR. HOTAIR rs10783618*C/C was associated with a 77% increased risk of SLE (OR = 1.77, 95%CI = 1.09?2.87, p = 0.020) under the recessive model. Similarly, MALAT1 rs3200401*T/T carriers were three times more likely to develop SLE (OR = 2.89, 95%CI = 1.42?5.90) under the recessive model. While the rs3200401*T/C genotype was associated with a 49?57% decreased risk of SLE under codominant (OR = 0.51, 95%CI = 0.31?0.82, p < 0.001) and over-dominant (OR = 0.43, 95%CI = 0.27?0.68, p < 0.001) models. LINC-ROR rs1942347*A/A patients were more likely to have a positive family history of SLE. At the same time, HOTAIR rs10783618*C/C was associated with a higher frequency of arthritis (p = 0.001) and the presence of oral ulcers (p = 0.002), while patients carrying rs10783618*T/T genotype were more likely to develop hair loss (p < 0.001), weight loss (p = 0.001), and neurological symptoms (p = 0.003). No 35626352 MALAT1 LncRNA Homo sapiens Glioblastoma brain tissues Expression[highly expressed] qRT-PCR MALAT1 expression was significantly upregulated in primary GB vs. normal brain tissues (p = 0.025). Increased MALAT1 expression in IDH1/2 wild-type primary GBs correlated with patient age and tumor localization (p = 0.032 and p = 0.025, respectively). A multivariate analysis showed that high MALAT1 expression was an unfavorable prognostic factor for overall survival (p = 0.034) in IDH1/2 wild-type primary GBs. No 31479414 MALAT1 LncRNA Homo sapiens Acute Coronary Syndrome 92 ACS patients and 92 controls Mutation(rs600231 ) Genotyping The prevalence of the GG genotype of rs600231 in ACS group was higher than that in control group (15.7% vs. 14.7%, P=0.048). The dominant model differed (AG + GG vs. AA) and the G allele of rs600231 in ACS group was higher than that in control group (for dominant model: 66.2% vs. 60.9%, P=0.014; for allele: 41.0% vs. 37.8%, P=0.042). In addition, in the AG and GG phenotypes, the relative expression of lncRNA MALAT1 was significantly higher in ACS patients than in controls with the same phenotypes (P<0.05). No 33968621 MAD2L1P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 550 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LYST-AS1-201 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 LOC442028 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC731605 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1011 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC730101 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Expression[highly expressed] qRT-PCR We found that LOC730101 was significantly upregulated in human osteosarcoma tissues compared with corresponding adjacent normal tissues (p < 0.01). Elevated LOC730101 expression was correlated with advanced clinical stage (p = 0.001) and distant metastasis (p = 0.005). Furthermore, survival assay revealed that osteosarcoma patients in the high LOC730101 expression group had significantly shorter 5-year overall survival time than those in the low LOC730101 expression group (p = 0.0002). No 30024599 LOC730098 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 958 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC729966 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC729739 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)93) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 LOC729732 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC729603 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 535 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC729056 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1039 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC729040 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 821 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC728730 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC728673 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LOC728175 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LOC727896 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 764 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC654342 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC653406 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 976 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC650866 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 628 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC646903 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC646890 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1040 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC646870 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1018 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC646665 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1053 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC646471 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC646358 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 539 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC646214 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 998 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC645965 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 726 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC645357 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 898 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC645166 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC644285 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1004 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC643711 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC643339 LncRNA Homo sapiens COVID-19 Thai population Regulation Genotyping Additionally, a suggestive locus on chromosome 12q22, harboring EEA1 and LOC643339, was associated with COVID-19 disease severity (p value 1.3 × 10-6 - 4.4 × 10-6, Q-Q plot λ = 0.997, odds ratio 0.28-0.31). EEA1 is involved in viral entry into cells, while LOC643339 is a long non-coding RNA. In summary, our study suggested loci on chromosomes 5q32 and 12q22 to be linked to COVID-19 disease susceptibility and disease severity, respectively. No 35013560 LOC613038 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC730102 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC90768 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LY86-AS1 LncRNA Homo sapiens Pemphigus 227 endemic PF patients and 194 controls Mutation(rs12192707 ) qRT-PCR//Genotyping//Microarray Among them, the LINC-PINT SNP rs10228040*A (OR = 1.47, p = .012) was also associated with increased susceptibility for sporadic PF (OR = 2.28, p = .002). Moreover, the A+ carriers of LY86-AS1*rs12192707 mark lowest LY86-AS1 RNA levels, which might be associated with a decreasing autoimmune response. No 33394553 LOC93429 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LY6G6E LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LY6E-DT LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Expression[lower expressed] qRT-PCR qPCR results indicated marked upregulation of CDKN2A-AS1, C7orf55, LINC00184, HEIH, and ZEB2 expression, whereas that of SNHG3, LINC00630, LOC100133669, APTR, LINC-PINT, and SEMA5A was downregulated in OC tissues as compared with levels in normal ovary tissues (Fig. ?(Fig.5b5b). No 31098301 LUCAT1-203 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[highly expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 10. No 31619123 LUCAT1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[LUCAT1/miR-5582-3p/TCF7L2 axis] RIP//Luciferase Report Assay//RNA Pull-Down Furthermore, LUCAT1 was more expressed in BCSCs than in breast cancer cells (BCCs) by lncRNA microarray chips. LUCAT1 up-regulation promoted proliferation of BCCs, while LUCAT1 down-regulation inhibited self-renewal of BCSCs. MiR-5582-3p was directly bound to LUCAT1 and TCF7L2 and negatively regulated their expression. LUCAT1 affected Wnt/β-catenin pathway. This study found LUCAT1 expression was related to tumor size (p = 0.015), lymph node metastasis (p = 0.002) and TNM staging (p < 0.001). High LUCAT1 expression indicated a shorter overall survival (p = 0.006) and disease-free survival (p = 0.011). No 31300015 LUCAT1 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[lower expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 LUCAT1 LncRNA Homo sapiens Crohn Disease plasma of patients with CD Expression(highly expressed) qRT-PCR LncRNA LUCAT1 was increased in plasma of patients with CD compared with the control group. The plasma LncRNA LUCAT1 level of patients with CD both in the clinical and endoscopic active phase was higher than that of both the clinical and endoscopic remission phase. No 34621310 LUCAT1 LncRNA Homo sapiens Pulmonary Disease, Chronic Obstructive serums of COPD patients Expression [highly expressed] RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//ELISA LncRNA LUCAT1 was upregulated in the serums of COPD patients. Correlation analysis further confirmed the strong correlation between LUCAT1 expression and inflammatory cytokines IL-1β, IL-6, and TNF-α. No 34125980 LUCAT1 LncRNA Homo sapiens Aortic Aneurysm, Thoracic aortic tissue Expression[lower expressed] qRT-PCR We found significantly reduced CARMN (p = 0.033) and LUCAT1 (p = 0.009) expression in aortic tissue samples from TAA patients. Relative expression of MALAT1 (p = 0.117) and SMILR (p = 0.610) did not differ in aortic tissue between the TAA and non-TAA groups. Expression of both LUCAT1 and SMILR was significantly decreased in TAA patients' blood plasma compared to controls (p = 0.018 and p = 0.032, respectively). No 32655720 LUCAT1 LncRNA Homo sapiens Sars-Cov-2 Vaccination Breakthrough Infections 57 VBT and unvaccinated COVID-19 patients Expression(lower expressed) RNA-seq//Bioinformatics Analysis Further, out of the 12 lncRNA genes, 7 lncRNAs are reported to modulate immune/inflammatory responses in infectious diseases. Out of the 7 lncRNAs, LUCAT1, MALAT1, NEAT1 and GAS5 were downregulated in the VBT. LUCAT1 is a negative regulator of interferon response, and downregulation of LUCAT1 suggests an activated interferon response (30). MALAT1 is known to negatively regulate the immune response and positively regulate the inflammatory response in the infected individuals, therefore downregulation of MALAT1 in the breakthrough infection suggests an upregulated immune response and downregulated inflammatory response (31, 32). NEAT1 and GAS5 also act as pro-inflammatory lncRNAs, and their downregulation is an indicator of decreased inflammatory response in the VBT (33, 34). Amongst the upregulated lncRNAs, ROR1-AS1, UGDH-AS1 and LINC00273 were upregulated in the VBT. The upregulation of ROR1-AS1 and LINC00273 indicates a heightened immune response, whereas upregulation of UGDH-AS1 suggests a decreased disease severity possibly modulated by MOV10 and EDN1 (8). No 36466827 LUCAT00 LncRNA Homo sapiens Carcinoma, Renal Cell Expression[highly expressed] Meta-analysis Meanwhile, up-regulation of LUCAT1 was significantly related to worse OS in ccRCC patients (HR = 1.51, 95% CI = 1.01-2.00). No 31577719 LUADT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues regulation[miR-34a/GAS1 Axis] qRT-PCR//Luciferase Report Assay In this study, we found that LUADT1 was upregulated in OSCC and predicted poor survival. LUADT1 may promote OSCC proliferation by regulating miR-34a/GAS1 axis. In this study, we found that LUADT1 was upregulated in OSCC and predicted poor survival. No 32494204 LSM1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LRRFIP1-215 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[lower expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 LRRC9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LRRC37A8P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LRRC37A4P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LRR1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LRP5L-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LRP10 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 LRBA LncRNA Homo sapiens Breast Neoplasms luminal A and B patients Interaction(miR-18 and miR-190b) qRT-PCR//Northern Blot//RNA Pull-Down//Western Blot We found that uc.147 is high expressed in luminal A and B patients. Additionally, we identifed 19 proteins that interact with lnc-uc.147 through mass spectrometry and demonstrated a high correlation of lnc-uc.147 with the neighbour gene expression and miR-18 and miR-190b. . For luminal A, a subtype usually associated with better prognosis, high uc.147 expression was associated with a poor prognosis and suggested as an independent prognostic factor. The silencing of uc.147 increases apoptosis, arrests cell cycle, and reduces cell viability and colony formation in BC cell lines. No 34387142 LRB1 LncRNA Homo sapiens Carcinoma, Hepatocellular serum Expression[highly expressed] qRT-PCR The results indicated that the serum LRB1 levels in patients with HCC were significantly increased compared with healthy volunteers. The serum LRB1 levels were positively associated with α-fetoprotein (AFP) expression, large tumor sizes, tumor stage (tumor-node metastasis or Barcelona Clinic Liver Cancer stage) and venous invasion, and were negatively associated with overall survival. No 30008842 LPAR3 CircRNA Homo sapiens Esophageal Neoplasms ESCC tissues and cells interaction[sponges microRNA-198] qRT-PCR//Microarray Circular RNA LPAR3 showed apparently high expression in ESCC tissues and cells, which was closely correlated with the clinical stage and lymph node metastasis of ESCC patients. However, it had no effect on ESCC cell proliferation. Circular RNA LPAR3 can regulate the miR-198-MET signal axis to promote the migration, invasion, and metastasis of esophageal cancer cells, which can thereby serve as a potential diagnostic and therapeutic target of esophageal cancer. Circular RNA LPAR3 showed apparently high expression in ESCC tissues and cells, which was closely correlated with the clinical stage and lymph node metastasis of ESCC patients. No 32495982 LPAR1 CircRNA Homo sapiens Alzheimer Disease cerebrospinal fluid Expression[highly expressed] qRT-PCR//Microarray By RT-qPCR, circ-LPAR1, circ-AXL and circ-GPHN were increased, whereas circ-PCCA, circ-HAUS4, circ-KIF18B and circ-TTC39C were decreased in AD patients compared with Ctrl subjects, and these circRNAs were disclosed to predict AD risk by receiver operating characteristics curve analysis. No 32315771 LOXL2-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck plasma of 28 cases with TNM I/II [early-stage squamous cell carcinoma (ESCC) group], 36 cases with TNM III/IV [advanced-stage squamous cell carcinoma (ASCC) group], 16 cases with dysplasia [oral premalignant lesion (OPL) group] and 16 healthy controls (H group) Regulation qRT-PCR//Microarray The expression level of ENST00000412740, NR_131012, ENST00000588803 and NR_038323 exhibited significant differences in the H, OPL, ESCC and ASCC groups (P<0.05). ROC curve and logistic regression analyses revealed that the diagnostic efficacy of the combined lncRNAs was more prominent than that of a single lncRNA, particularly in the ESCC and ASCC groups. No 33552289 LOXL1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOXL1-AS1 LncRNA Homo sapiens Ovarian Neoplasms Serum Expression[highly expressed] qRT-PCR The expression of LOXL1-AS1 was dramatically higher in EOC patients compared to healthy controls (p < 0.01). LOXL1-AS1 yielded an area under the ROC curve of 0.843 with 65.3% sensitivity and 68.2% specificity in discriminating high-grade EOC from healthy controls. It was also shown that LOXL1-AS1 expression was associated with advanced FIGO stage (p = 0.004) and positively distant metastasis (p = 0.013). Kaplan-Meier assays revealed that patients with high LOXL1-AS1 expression had a shorter overall survival than those with low expression (p = 0.0006). No 32449981 LOXL1-AS1 LncRNA Homo sapiens choriocarcinoma human choriocarcinoma cells Regulation(miR-515-5p ) Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay Our results showed that human placental trophoblast cells had higher level of LOXL1-AS1 in comparison to human choriocarcinoma cells, however, human placental trophoblast cells had lower level of miR-515-5p. In addition, the expression of CyclinD1, MMP2, MMP9 were significantly decreased in JeG-3 cell lines. We observed lower cell survival rate and lower cell migration number in JeG-3 cell lines. Our results demonstrated that LOXL1-AS1 could target miR-515-5p, and subsequently reverse the inhibitory effect of LOXL1-AS1 on proliferation and migration in JEG-3 cells. Also, lower expressions of p-p65 and p-IкBα in JeG-3 cells showed that miR-515-5p could reversed the inhibitory effect of LOXL1-AS1 on NF-κB signaling pathway. No 33278425 LONRF1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC93463 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 915 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375510 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 964 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375472 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 877 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375464 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 780 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102724471 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1033 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102724318 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 833 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102724281 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 564 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102724271 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 702 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102724210 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 969 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102724168 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 592 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102724069 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 531 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102724040 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1003 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102723985 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 617 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102723956 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 788 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102723927 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 790 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102723746 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 842 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102723654 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 547 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102723640 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC102723622 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 676 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102723549 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 654 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102723427 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC102723415 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 766 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102723345 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC102640791 LncRNA Homo sapiens Sepsis cell model of sepsis Interaction(miR-320-5p) qRT-PCR//ELISA//Luciferase Report Assay Results Compared with the control group, the LPS group had lower expression of LOC102640791 and higher expression of miR-320-3p. Compared with the LPS group, the LPS group with high expression of LOC102640791 and the LPS group with low expression of miR-320-3p had higher expression of pro-inflammatory factors (TNF-α, IL-6 and IL-8) and lower expression of anti-inflammatory factors (IL-4 and IL-10). Wild type LOC102640791 can inhibit the luciferase activity of miR-320-3p. No 35786454 LOC102550137 LncRNA Mus musculus Silicosis silicotic rat lungs Expression[lower expressed] qRT-PCR//RNA-seq The expression of LOC103691771, LOC102549714 and LOC102550137 was upregulated, while the expression of LOC103693125 and LOC103692016 was downregulated in silicotic rat lungs and TGF-β3-induced fibroblast, which was consistent with the results of RNA-sequencing. No 32028236 LOC102549714 LncRNA Mus musculus Silicosis silicotic rat lungs Expression[highly expressed] qRT-PCR//RNA-seq The expression of LOC103691771, LOC102549714 and LOC102550137 was upregulated, while the expression of LOC103693125 and LOC103692016 was downregulated in silicotic rat lungs and TGF-β2-induced fibroblast, which was consistent with the results of RNA-sequencing. No 32028236 LOC101930307 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 627 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101930275 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 549 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101929964 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 652 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101929758 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 LOC101929732 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 838 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101929670 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 752 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101929567 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 544 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101929532 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC102724450 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC102724517 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 693 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101929482 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 907 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102724579 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1036 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369652 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 606 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369595 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 665 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369537 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 578 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369519 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 930 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369495 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 713 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369458 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1066 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369437 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 639 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369413 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 663 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369313 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 658 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369212 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 636 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369208 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 941 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369196 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 807 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369170 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 651 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369165 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 947 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369161 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 827 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369159 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 812 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369147 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 675 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369144 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 896 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369141 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 747 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC103693125 LncRNA Mus musculus Silicosis silicotic rat lungs Expression[lower expressed] qRT-PCR//RNA-seq The expression of LOC103691771, LOC102549714 and LOC102550137 was upregulated, while the expression of LOC103693125 and LOC103692016 was downregulated in silicotic rat lungs and TGF-β4-induced fibroblast, which was consistent with the results of RNA-sequencing. No 32028236 LOC103692016 LncRNA Mus musculus Silicosis silicotic rat lungs Expression[lower expressed] qRT-PCR//RNA-seq The expression of LOC103691771, LOC102549714 and LOC102550137 was upregulated, while the expression of LOC103693125 and LOC103692016 was downregulated in silicotic rat lungs and TGF-β5-induced fibroblast, which was consistent with the results of RNA-sequencing. No 32028236 LOC103691771 LncRNA Mus musculus Silicosis silicotic rat lungs Expression[highly expressed] qRT-PCR//RNA-seq The expression of LOC103691771, LOC102549714 and LOC102550137 was upregulated, while the expression of LOC103693125 and LOC103692016 was downregulated in silicotic rat lungs and TGF-β1-induced fibroblast, which was consistent with the results of RNA-sequencing. No 32028236 LOC103611081 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC102724906 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 923 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102724898 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 857 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102724832 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1048 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102724720 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 856 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102724676 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 733 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC102724637 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1077 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101929523 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101929441 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC105369748 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[LOC105369748/miR-5095/MBD2 signaling axis] ISH//qRT-PCR We identified that LOC105369748 expression was significantly elevated in HCC tissues compared with normal tissues based on bioinformatics analysis, quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis and in situ hybridization (ISH) examination.In conclusion, our findings elucidate that the LOC105369748/miR-5095/MBD2 signaling axis regulates the HCC progression and may be a novel therapeutic avenue. Moreover, we found that the LOC105369748 overexpression was associated with poor prognosis in patients with HCC. No 30912130 LOC101928075 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101928020 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 778 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101927990 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 530 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101927910 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 813 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101927884 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101927881 LncRNA Homo sapiens Breast Neoplasms serum of BC patients and healthy subjects Expression [lower expressed] RNA-seq After a comprehensive comparison of the BC patients and healthy subjects, we discovered five up-regulated exo-lncRNAs and six down-regulated exo-lncRNAs of interest.  No 34733934 LOC101927854 LncRNA Homo sapiens Breast Neoplasms serum of BC patients and healthy subjects Expression [lower expressed] RNA-seq After a comprehensive comparison of the BC patients and healthy subjects, we discovered five up-regulated exo-lncRNAs and six down-regulated exo-lncRNAs of interest.  No 34733934 LOC101927759 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101927752 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101927752 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 731 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101927746 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101927587 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 562 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101927560 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 999 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101927551 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 802 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101927432 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 888 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101927391 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 679 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101927354 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101927257 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101927196 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1025 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101927157 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 792 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101927141 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101927092 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 571 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101927078 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 871 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101927027 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101927021 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101926980 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 781 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101926915 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101926908 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LOC101926907 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 674 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101926897 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 LOC101928020 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101928096 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 620 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101929356 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 959 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928098 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101929340 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101929188 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101929165 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 537 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101929138 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1074 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101929106 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101929098 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 889 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928989 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 762 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928936 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101928932 LncRNA Homo sapiens Breast Neoplasms serum of BC patients and healthy subjects Expression [highly expressed] RNA-seq After a comprehensive comparison of the BC patients and healthy subjects, we discovered five up-regulated exo-lncRNAs and six down-regulated exo-lncRNAs of interest. No 34733934 LOC101928926 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 774 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928895 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 804 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928804 LncRNA Homo sapiens Hearing Loss, Noise-Induced blood Expression[highly expressed] qRT-PCR LncRNAs were verified by qRT-PCR, namely, LOC101928211, LOC101928804, and BANCR. The expression of LOC101928211 and LOC101928804 in the NIHL group was significantly higher than that in the exposed group, while the expression of BANCR was obviously decreased (P<0.001). No 31807550 LOC101928705 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 931 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928674 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101928673 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 717 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928667 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 776 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928514 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 832 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928489 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101928462 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 623 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928446 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 618 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928429 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101928421 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 975 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928389 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 532 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928278 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 977 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928272 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101928266 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC101928236 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1052 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101928211 LncRNA Homo sapiens Hearing Loss, Noise-Induced blood Expression[highly expressed] qRT-PCR LncRNAs were verified by qRT-PCR, namely, LOC101928211, LOC101928804, and BANCR. The expression of LOC101928211 and LOC101928804 in the NIHL group was significantly higher than that in the exposed group, while the expression of BANCR was obviously decreased (P<0.001). No 31807550 LOC101928140 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC105369653 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 714 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369817 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 704 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375434 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 848 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374097 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1024 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374052 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 557 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374005 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 727 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373930 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 908 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373923 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 914 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373922 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 570 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373917 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 576 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373867 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 970 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373844 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1015 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373827 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 784 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373802 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 556 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373799 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 541 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373797 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 841 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373794 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 876 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373658 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 608 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373654 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 655 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373653 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 688 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373589 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 601 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373561 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 666 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373473 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 719 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373420 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 LOC105373330 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 980 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373301 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 705 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373264 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 720 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373243 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 851 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373192 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 874 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373160 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 845 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373117 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 737 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373063 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 683 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105373045 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 536 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374082 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1007 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374130 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 622 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372964 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 891 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374162 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 607 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375426 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 929 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375407 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 599 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375337 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 861 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375222 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 551 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375201 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 850 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375184 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 878 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375170 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1032 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375152 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 629 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105375150 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 732 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374839 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 955 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374812 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1006 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374766 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 610 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374718 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 661 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374650 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 545 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374612 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 873 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374605 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 789 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374598 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 598 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374584 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 582 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374462 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1038 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374450 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 777 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374439 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 575 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374422 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 644 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374339 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1021 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374333 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 577 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374256 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1061 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374213 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1054 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374182 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 645 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374181 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 567 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105374166 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 692 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372983 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 840 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372960 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 847 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369818 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 573 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370977 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 1035 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370897 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 801 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370888 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC105370841 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 647 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370837 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1020 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370830 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 864 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370765 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 844 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370761 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 668 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370726 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 794 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370651 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1009 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370569 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 748 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370567 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 712 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370565 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 982 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370526 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC105370524 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 937 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370461 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 771 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370460 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 808 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370439 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1047 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370417 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 986 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370415 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 760 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370354 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 710 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370315 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 672 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370258 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 751 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370155 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 657 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370154 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1027 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370137 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 580 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370081 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 944 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370048 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 690 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369993 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1073 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105369857 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 757 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105370915 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 828 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105371094 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1042 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372923 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 744 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105371232 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 817 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372900 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 728 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372882 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 779 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372759 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 902 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372709 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 585 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372685 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1078 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372601 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 938 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372525 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1075 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372470 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 994 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372467 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 796 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372426 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 836 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372165 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 LOC105372162 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 992 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372145 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 974 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372105 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 814 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372097 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 631 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372092 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 735 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372090 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 722 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105372019 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1070 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105371996 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 818 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105371928 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 919 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105371871 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 858 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105371870 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 703 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105371862 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1058 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105371669 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 786 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105371607 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 809 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105371602 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 799 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105371408 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 734 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105371374 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 912 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC105371267 LncRNA Homo sapiens Breast Neoplasms Northern Chinese Han Females Interaction(rs6499221, rs3931698, rs8044565, rs3852740, rs111577197) Genotyping In this study, rs3931698 was a protective factor of BC in total (GG homozygote: OR = 0.30, 95% CI: 0.11-0.82, p=0.018; recessive model: OR = 0.30, 95% CI: 0.11-0.84, p=0.021). In addition, rs6499221 and rs3852740 were also associated with BC susceptibility among patients at age <52 years and patients with BC in a positive status. Thus, the haplotype analysis had a negative result for the incidence of BC (p > 0.05), and haplotype consisting of rs8044565 and rs111577197 was nonsignificantly associated with the BC risk. Finally, MDR and FPRP analyses also validated the result of this study. In stratification analysis based on the average age of 52 years and clinical characteristics (PR status, III-IV TNM stage), rs3931698 was also demonstrated to be associated with BC susceptibility. No 34475952 MALAT1 LncRNA Homo sapiens Ischemic Stroke blood Expression[lower expressed] qRT-PCR Plasma concentrations of inflammation factors (including C-reactive protein (CRP), tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-8, IL-10, IL-17, and IL-22) were measured and RFS was calculated. lnc-MALAT1 expression was decreased in AIS patients compared to controls, and it had a close correlation with AIS (AUC=0.791, 95% CI: 0.735-0.846) No 33111743 MALAT1 LncRNA Homo sapiens Myocardial Infarction MI patients Mutation(rs3200401 ) Genotyping The MALAT1 rs3200401 CT + TT genotypes could be a risk factor for MACCEs in MI patients, suggesting that the MALAT1 gene may become a biomarker for poor prognosis in MI patients. The MALAT1 rs3200401 CT + TT genotypes could be a risk factor for MACCEs in MI patients, suggesting that the MALAT1 gene may become a biomarker for poor prognosis in MI patients. No 35392816 MALAT1 LncRNA Homo sapiens Coronary Artery Disease blood Mutation[rs4102217 ] Genotyping In a stratified analysis, we found that non-drinkers with GC genotype and the recessive model of rs4102217 had higher CAD risk (P=0.010, odds ratio (OR): 1.96, 95% confidence interval (CI) = 1.17-3.28; P=0.026, OR: 1.73, 95% CI = 1.07-2.79) and diabetes mellitus (DM) history group (P=0.010, OR: 4.07, 95% CI = 1.41-11.81; P=0.019, OR: 3.29, 95% CI = 1.22-8.88). In SNP-SNP interactions analysis between MALAT1 and CAD risk, we found rs4102217 had an increase in smokers (GG: OR: 2.04, 95% CI = 1.42-2.92; CC+GC: OR: 2.64, 95% CI = 1.64-4.26) and a decrease in drinkers (CC+GC: OR: 0.33, 95% CI = 0.20-0.55). Smokers with MALAT1 rs619586 AA genotype (OR: 2.20, 95% CI = 1.57-3.07) and GG+AG genotype (OR: 2.11, 95% CI = 1.17-3.81) had a higher risk of CAD. Moreover, drinkers with AA genotype (OR: 0.22, 95% CI = 0.10-0.48) and GG+AG genotype (OR: 0.38, 95% CI = 0.22-0.65) had a lower risk of CAD. According to the MDR software, MALAT1 rs4102217 polymorphism-smoking-drinking was the best interaction model, which has higher risk of CAD (Testing Bal.ACC. = 0.6979). No 30833365 NDUFV2P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 909 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 NDUFS7-204 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 NDUFC1-202 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 NDUFB9-205 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 NDUFB10-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 NDUFA6-DT LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NDC1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 nc-SPARCL1-1 LncRNA Homo sapiens non-alcoholic steatohepatitis sera Interaction(HSPD1/MMP14/ITGB1/miR-6881-5P/Lnc-SPARCL1-1:2 panel) qRT-PCR//Bioinformatics Analysis We observed up-regulation of Lnc-SPARCL1-1:2 lncRNA that led to upregulation of miR-6881-5P with a subsequent increase in levels of HSPD1, MMP14, and ITGB1 mRNAs. In addition, ROC curve analysis was done, with discriminative cutoff values that aided discrimination between NASH cases and control, and also between NAFLD, simple steatosis and NASH. No 34572434 NCKAP5 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NCK1-DT LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NCK1-DT LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] qRT-PCR//RNA Pull-Down//RIP Increased expression of NCK1-AS1, MSH2, and decreased expression of miR-134-5p were observed in cervical cancer tissues. No 30221354 NCK1-DT LncRNA Homo sapiens Prostatic Hyperplasia blood Interaction[TGF-β1] qRT-PCR It was revealed in the present study that plasma NCK1-AS1 was upregulated in patients with PC when compared with patients with benign prostatic hyperplasia (BPH) and healthy controls. Overexpression of NCK1-AS1 led to significantly upregulated transforming growth factor (TGF)-β1, while TGF-β1 overexpression failed to significantly affect NCK1-AS1 in PC cells. NCK1-AS1 overexpression led to promoted migration and invasion. TGF-β inhibitor played an opposite role and attenuated the effects of NCK1-AS1 overexpression. Therefore, NCK1-AS1 may upregulate TGF-β1 to promote PC. No 31807161 NCBP2AS2-1 LncRNA Homo sapiens COVID-19 COVID-19 patients Expression(highly expressed) qRT-PCR Results revealed the decreased expression of A2M-AS1 and FLVCR1 in COVID-19 patients. Additionally, they showed the increased expression of DBH-AS1, FLVCR1-DT, and NCBP2AS2. Both FLVCR1-DT and NCBP2AS2 showed a positive correlation with interleukin-6 (IL-6). DBH-AS1 and FLVCR1-DT had a significant association with mortality, complications, and mechanical ventilation. A significant negative correlation was found between A2M-AS1 and NCBP2AS2-1 and between FLVCR1 and FLVCR1-DT. No 36359290 NCBP2AS2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NCAPH-207 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 NCAPG2 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 NCAPG LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NCAPG LncRNA Homo sapiens Lung Neoplasms LUAD tissues Regulation(AC099850.3/NCAPG axis) Bioinformatics Analysis Both NCAPG and lncRNA AC099850.3 were over-expressed in LUAD tissues, and correlated with tumor progression and poor prognosis in LUAD. LncRNA AC099850.3 was identified as a potential regulator of NCAPG expressions. The AC099850.3/NCAGP axis was markedly correlated with EGFR mutations and IC50 of EGFR-TKIs. Besides, elevated NCAPG levels were associated with EGFR-TKIs resistance in 57 LUAD patients undergoing TKIs treatment. Gene set enrichment analysis revealed that both AC099850.3 and NCAGP were abundant in the cell cycle and the p53 signaling pathway. Both NCAPG and lncRNA AC099850.3 were over-expressed in LUAD tissues, and correlated with tumor progression and poor prognosis in LUAD. No 36061963 NCAPG LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 NBR2 LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 NBPF25P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NBEAP4 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 579 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 NBDY LncRNA Homo sapiens Alzheimer Disease blood Expression[highly expressed] qRT-PCR//Microarray As shown in Fig. 4, compatible with microarray results, expression of lncRNA lnc-AL445989.1-2, TTC39C-AS1, and LINC01420 is significantly high, and lnc-CSTB-1 and LOC401559 are significantly low in the patient group when compared with control groups. No 32885358 NBAT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NBAT1 LncRNA Homo sapiens Ischemic Stroke AIS patients Regulation(TUG1, miR-21) qRT-PCR Our study showed that NBAT1 serum expression levels were elevated in AIS patients compared to controls. NBAT1 expression levels were observed to be positively correlated with triglycerides, TUG1, and miR-21 No 36250025 NBAT1 LncRNA Homo sapiens Carcinoma, Renal Cell cell lines Regulation[miR-346/GSK-3β axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay NBAT1 was significantly downregulated in RCC cells. Furthermore, NBAT1 negatively regulated miR-346 expression. In addition, miR-346 overexpression and the knockdown of GSK-3β, a direct target of miR-346 could overturn the inhibitory effect of NBAT1 on Wnt/β-catenin signaling and cell proliferation, migration, and invasion. NBAT1 functioned as an endogenous sponge by competing for miR-346 binding to GSK-3β and therefore alleviated RCC cells. No 31298469 NAPSB LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NAPA LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NAP1L4P3 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)36) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 NAMPT-212 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 NDUFS8-213 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 Neat1 LncRNA Mus musculus Intervertebral Disc Degeneration intervertebral disks,human nucleus pulposus cells regulation[BAX/BAK Pathway] qRT-PCR//Tunel//Western Blot The relative NEAT1 expression was significantly upregulated in the IVDD rat model and the denatured HNPC.NEAT1 played its role in IVDD progression via partly by mediating the miR-195 expression and might be used as a potential target for IVDD therapy. No 32850952 NALCN-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 Neat1 LncRNA Mus musculus Non-alcoholic Fatty Liver Disease liver tissues Interaction[miR-146a-5p/ROCK1] qRT-PCR//Luciferase Report Assay High levels of NEAT1 and ROCK1, and low level of miR-146a-5p were identified in NAFLD models. NEAT1 could target miR-146a-5p to promote ROCK1 expression. Knockdown of NEAT1, overexpression of miR-146a-5p and knockdown of ROCK1 inhibited lipid accumulation through activating AMPK pathway. No 31484042 NEAT1 LncRNA Homo sapiens Malignant Tumour Lympha Node Metastasis Expression[highly expressed] Meta-analysis We have collected all the concerned studies about NEAT1 and researched the relationship between NEAT1 and lymph node metastasis. We have searched the studies by seeking database PubMed, Web of Science, and China National Knowledge Infrastructure (up to 10 January 2019), as well as a total of 821 patients from eight studies topics and made accordingly meta-analysis. By analyzing the data, we have found that the result is the high expression of NEAT1 associate with the metastasis of lymph node in different malignant tumours. The high level of NEAT1 expression can predict the metastasis of lymph node (OR = 3.36, 95% CI = 1.66-6.77, p = .000) and it is a molecular marker of positive lymph node for treatment. No 31213091 NEAT1 LncRNA Homo sapiens renal fibrosis renal tissues Interaction(miR-31) Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//H&E Staining//ELISA//IHC We showed that NEAT1 was highly expressed, whereas miR-31 was decreased in renal fibrosis. NEAT1 was found to directly bind miR-31 to positively regulate RhoA expression. Furthermore, NEAT1 silencing inhibited renal fibrosis and inflammation and suppressed the RhoA/ROCK1 signaling pathway. However, knockdown of miR-31 could reverse these effects. NEAT1 silencing or overexpression of miR-31 alleviated renal fibrosis in vivo. No 36440854 NEAT1 LncRNA Homo sapiens Non-alcoholic Fatty Liver Disease hepacytes Regulation[AMPK/SREBP-1 signaling] qRT-PCR//Western Blot NEAT1 and miR-140 are upregulated in hepacytes under the NAFLD conditions.The NEAT1-miR-140 axis play a crucial role in modulation of NAFLD via inactivation of AMPK/SREBP1 signaling. This study may provide a novel insight for the treatment of NAFLD. No 31239155 NEAT1 LncRNA Homo sapiens Non-alcoholic Fatty Liver Disease cell lines Regulation[miR-506/GLI3 axis ] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot NEAT1 was upregulated while miR-506 was downregulated in the progression of NAFLD. lncRNA NEAT1 could regulate fibrosis, inflammatory response, and lipid metabolism via the miR-506/GLI3 axis as a ceRNA, which is a novel mechanistic role in the regulation of NAFLD. No 31957704 NEAT1 LncRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Regulated[up-regulated] qRT-PCR//ELISA Lnc-NEAT1 expression was elevated in AECOPD patients and stable COPD patients compared to healthy controls, as well as in AECOPD patients compared to stable COPD patients; moreover, ROC curves showed that lnc-NEAT1 predicted increased COPD susceptibility and acute exacerbation risk of COPD. Also, lnc-NEAT1 expression positively correlated with GOLD stage and levels of TNF-α, IL-1β, IL-6 and IL-17 in both AECOPD and stable COPD patients. Furthermore, lnc-NEAT1 expression negatively correlated with miR-193a expression, and miR-193a could predict decreased COPD susceptibility and acute exacerbation risk, and negatively correlated with GOLD stage and levels of TNF-α, IL-1β, IL-6 and IL-17 in both AECOPD and stable COPD patients. lnc-NEAT1 predicts elevated COPD susceptibility and increased acute exacerbation risk, and positively correlates with disease severity as well as inflammation, but negatively associates with miR-193a in COPD patients. No 31934120 NEAT1 LncRNA Homo sapiens Non-alcoholic Fatty Liver Disease PBMCs Expression(highly expressed) ELISA The relative expressions of lncRNA NEAT1 in the PBMCs of the NAFLD group were remarkably higher than they were in the control group (P<0.05).The lncRNA NEAT1 expressions in the NAFLD patients presented a remarkable positive correlation with the ALT, GGT, TC, and TG levels (P<0.05). The HEPC levels were positively correlated with the ALT, GGT, TC, and TG levels in the NAFLD patients (P<0.05), and the lncRNA NEAT1 expressions in the peripheral blood had a positive correlation with HEPC (P<0.05). No 35559416 NEAT1 LncRNA Homo sapiens Pulmonary Fibrosis PF tissues and cells regulation[miR-9-5p and TGF-β signaling pathway] qRT-PCR//Luciferase Report Assay//Western Blot We observed that NEAT1 was significantly upregulated while miR-9-5p was downregulated in PF tissues and TGF-β1-induced cells. Taken together, our findings showed that NEAT1 knockdown attenuated PF via the regulatory of miR-9-5p and TGF-β signaling to repress EMT and might provide new therapeutic targets for PF patients. No 32894569 NEAT1 LncRNA Homo sapiens Myocardial Infarction blood Expression[highly expressed] RNA-seq RNA-seq revealed deregulated protein-coding transcripts and lncRNAs in post-MI PBMCs, among which nuclear enriched abundant transcript (NEAT1) was the most highly expressed lncRNA, and the only one significantly suppressed in patients. No 30924864 NEAT1 LncRNA Homo sapiens Diabetic Retinopathy patients with DR regulation[TGF-β1 and VEGF signaling pathways] qRT-PCR Here, we found the NEAT1 level was significantly elevated in patients with DR, in the retina of diabetic rats and mice. Hence, we concluded NEAT1 might contribute to the development of DR through activating TGF-β1 and VEGF. No 32356340 NEAT1 LncRNA Homo sapiens Coronary Disease CHD patients Expression(highly expressed) qRT-PCR//ELISA Lnc-NEAT1 was higher in CHD patients than in controls (p < 0.001). In CHD patients, lnc-NEAT1 positively associated with Gensini score (r = 0.323, p < 0.001). No 35478415 NEAT1 LncRNA Homo sapiens Sinonasal Squamous Cell Carcinoma SNSCC tissues and cells regulation[miR-195-5p/VEGFA axis] Flow Cytometry//qRT-PCR//MTT//Western Blot In SNSCC tissues and cells, the expressions of NEAT1 and VEGFA were up-regulated while the expression of miR-195-5p was down-regulated, and NEAT1 was negatively correlated with miR-195-5p yet positively correlated with VEGFA. Down-regulating NEAT1 inhibited the viability and vasculogenic mimicry formation of SNSCC cells yet promoted their apoptosis via the miR-195-5p/VEGFA axis, providing a possible therapeutic target for SNSCC treatment. No 33146672 NEAT1 LncRNA Homo sapiens Hypothyroidism Interaction(miR-126/TRAF7 pathway) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay Furthermore, lncRNA NEAT1 was upregulated upon TSH treatment and could function as a ceRNA and bind to miR-126, thus, modulating its expression level and vascular function. Finally, the NEAT1/miR-126/TRAF7 axis functions in response to TSH and regulates endothelial functions in SCH in vitro and in vivo. No 33677813 NEAT1 LncRNA Homo sapiens Diabetes Mellitus 200 were subjects with T2DM and 200 were healthy subjects Expression(highly expressed) qRT-PCR Compared with healthy controls, patients with T2DM showed an overall increase in expression of lncRNAs NKILA, NEAT, MALAT1, and MIAT by 3.94-fold, 5.28-fold, 4.46-fold, and 6.35-fold, respectively. Altered NEAT1 expression was significantly associated with weight loss (p=0.04), fatigue (p=0.01), slow wound healing (p=0.002), blurred vision (p=0.008), loss of appetite (p=0.007), smoking (p<0.0001), and alcoholism (p<0.0001). Altered NEAT1 expression was significantly associated with weight loss (p=0.04), fatigue (p=0.01), slow wound healing (p=0.002), blurred vision (p=0.008), loss of appetite (p=0.007), smoking (p<0.0001), and alcoholism (p<0.0001). No 33436407 NEAT1 LncRNA Homo sapiens Stomatitis, Aphthous Plasma Expression(highly expressed) qRT-PCR//ELISA Plasma NEAT1, IL-2, IL-1β, and TNF-α levels were the highest in the S-RAS group, followed in turn by NS-RAS and control groups. NEAT1 was positively and significantly correlated with IL-2, IL-1β, and TNF-α across S-RAS and NS-RAS samples, but not control samples. After treatment, plasma levels of NEAT1, IL-2, IL-1β, and TNF-α decreased significantly. Moreover, a higher recurrence rate was observed during the follow-up in patients with high plasma NEAT1 levels. No 34972503 NEAT1 LncRNA Homo sapiens Breast Neoplasms Serum samples Expression(highly expressed) qRT-PCR Assessment of lncRNA XIST, and lncRNA NEAT1 expression was performed using real time PCR. Expression levels of the investigated lncRNAs were significantly higher in BC patients as compared to the other groups. Both lncRNAs were significantly correlated with BC laterality, lymph node involvement, and clinical stages. LncRNA NEAT1 reported a significant aberrant expression with pathological types, histological grading and, hormonal status. No 33602501 NEAT1 LncRNA Homo sapiens Oligodendroglioma POG tissues Interaction(miR-143 ) qRT-PCR The expression levels of miR-21, miR-106a, miR-10b, and LncRNA NEAT1 were higher, and the expression level of miR-143 was lower in POG tissues compared with normal brain tissues (p = 0.006, p = 0.032, p = 0.034, p = 0.002, and p = 0.001, respectively). No 33744906 NEAT1 LncRNA Homo sapiens Behcet Syndrome BD patients Expression(highly expressed) qRT-PCR Compared to controls, the significant upregulation of NEAT1 {median [interquartile range (IQR)] = 1.68 (0.38-7.7), p < 0.0001} and downregulation of lnc-DC [median (IQR) = 0.2 (0.12-1.39), p = 0.03] were detected in the sera collected from BD patients. Also, high NEAT1 levels were significantly associated with a negative pathergy test, while higher lnc-DC was significantly associated with a positive family history Higher serum expression levels of NEAT1 and lnc-DC were significantly associated with the following clinical presentations: cutaneous lesions, vascular manifestations, articular manifestations, neurological manifestations, and higher disease activity score. No 35127819 NEAT1 LncRNA Homo sapiens COVID-19 saliva and nasopharyngeal swab samples Expression(highly expressed) qRT-PCR We evaluated the expression of lncRNAs NEAT1, MALAT1, and MIR3142 in saliva and nasopharyngeal swab from SARS-CoV-2 positive (n = 34) and negative patients (n = 46). A higher expression of the lncRNAs NEAT1 and MALAT1 (p < 0.05) were found in positive samples. NEAT1 had a higher expression mainly in saliva samples (p < 0.001), and MALAT1 was upregulated in nasopharyngeal samples (p < 0.05). Area under the ROC curve for NEAT1 in saliva was 0.8067. This study was the first to investigate the expression of lncRNAs in saliva and nasopharyngeal samples of COVID-19 patients, which gives new insights into the initial response to infection and infectivity and may provide new biomarkers for severity and targets for therapy. No 34463043 NEAT1 LncRNA Homo sapiens COVID-19 SARS-CoV-2-infected cells Interaction(hsa-miR-374-5p and hsa-miR-155-5p) Bioinformatics Analysis Our analysis suggested that lncRNA NEAT1 might regulate the host immune response through two miRNAs, hsa-miR-374-5p and hsa-miR-155-5p, which control the expression of SOCS1, IL6, IL1B, CSF1R, CD274, TLR6, and TNF. No 34675627 NEAT1 LncRNA Homo sapiens COVID-19 80 COVID-19 patients Expression(highly expressed) qRT-PCR NEAT1 and TUG1 expression levels were higher in COVID-19 patients compared with controls (P<0.001). NEAT1 and TUG1 had significant correlations with the measured cytokines, and based on the multivariate regression analysis, NEAT1 is the independent predictor for survival in COVID-19 patients (P=0.02). No 35982898 NEAT1 LncRNA Homo sapiens COVID-19 peripheral blood mononuclear cells Expression(highly expressed) RNA-seq The immunomodulatory long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 were highly differentially expressed between mild and severe patients in multiple cell types. No 35007307 NEAT1 LncRNA Homo sapiens Diabetic Ischemic Stroke Diabetic patients with stroke Interaction(miR-124) ELISA In the DM+AIS group, NEAT1 expression was considerably higher, compared with AIS group and with control group. In comparison to the AIS-only patients, DM patients and controls, miR-124 expression was considerably lower in the DM+AIS group. NEAT1 was shown to have good predictive value for AIS risk in diabetics, based on Receiver Operating Characteristic (ROC) curve analysis. In both the DM+AIS and the AIS group, NEAT1 levels was strongly linked with the National Institutes of Health Stroke Scale (NIHSS) score. No 36027040 NEAT1 LncRNA Homo sapiens influenza Epigenetics(splicing isoforms ) RNA-seq We show that NEAT1_2 splicing and up-regulation can be induced by ectopic co-expression of the HSV-1 immediate-early proteins ICP22 and ICP27, potentially linking increased expression and splicing of NEAT1_2. To identify other conditions with NEAT1_2 splicing, we performed a large-scale screen of published RNA-seq data. This uncovered both induction of NEAT1_2 splicing and poly(A) read-through similar to HSV-1 and IAV infection in cancer cells upon inhibition or knockdown of CDK7 or the MED1 subunit of the Mediator complex phosphorylated by CDK7. No 36279270 NEAT1 LncRNA Homo sapiens Sars-Cov-2 Vaccination Breakthrough Infections 57 VBT and unvaccinated COVID-19 patients Expression(lower expressed) RNA-seq//Bioinformatics Analysis Further, out of the 12 lncRNA genes, 7 lncRNAs are reported to modulate immune/inflammatory responses in infectious diseases. Out of the 7 lncRNAs, LUCAT1, MALAT1, NEAT1 and GAS5 were downregulated in the VBT. LUCAT1 is a negative regulator of interferon response, and downregulation of LUCAT1 suggests an activated interferon response (30). MALAT1 is known to negatively regulate the immune response and positively regulate the inflammatory response in the infected individuals, therefore downregulation of MALAT1 in the breakthrough infection suggests an upregulated immune response and downregulated inflammatory response (31, 32). NEAT1 and GAS5 also act as pro-inflammatory lncRNAs, and their downregulation is an indicator of decreased inflammatory response in the VBT (33, 34). Amongst the upregulated lncRNAs, ROR1-AS1, UGDH-AS1 and LINC00273 were upregulated in the VBT. The upregulation of ROR1-AS1 and LINC00273 indicates a heightened immune response, whereas upregulation of UGDH-AS1 suggests a decreased disease severity possibly modulated by MOV10 and EDN1 (8). No 36466827 NEAT1 LncRNA Homo sapiens Stroke serum of 181 CVS patients Expression(highly expressed) qRT-PCR When compared to controls, there was a statistically higher level of lncNEAT1 in each case group (median (IQR) = 3.68 (1.35-7.35) and 3.05 (0.95-6.45) for the hypertensive and non-hypertensive groups, respectively, with a significantly higher level in the hypertensive group (P = 0.04). No 36439973 NEAT1 LncRNA Homo sapiens Rhinitis, Allergic pediatric AR patients, DCs and HCs Interaction(microRNA-125a) qRT-PCR Lnc-NEAT1 was overexpressed, while miR-125a downregulated in pediatric AR patients compared to DCs and HCs (all p < 0.001). Moreover, lnc-NEAT1 expression negatively correlated with miR-125a expression in pediatric AR patients (p = 0.002), but not in DCs (p = 0.226) or HCs (p = 0.237). Additionally, lnc-NEAT1 expression positively, while miR-125a expression negatively correlated with Th2 cells and IL-10 (all p < 0.05), but they were not correlated with Th1 cells or IFN-γ in pediatric AR patients. Furthermore, in pediatric AR patients, lnc-NEAT1 expression positively associated with TNSS (p < 0.001), sneezing score (p = 0.006), and congestion score (p = 0.008); miR-125a expression was negatively related to TNSS (p < 0.001), itching score (p = 0.040), and sneezing score (p = 0.005). No 35064698 Neat1 LncRNA Mus musculus Breast Neoplasms serum EVs Interaction(miR-141-3p) RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay NEAT1 expression in serum EVs was high and related to lymph node metastasis, progesterone receptor, estrogen receptor and Ki-67 in BC patients. After EV treatment, NEAT1 and KLF12 levels were increased, miR-141-3p expression was decreased, the abilities of proliferation, invasion, migration and in vivo metastasis were enhanced, and the sensitivity of cells to cisplatin, paclitaxel and 5-fluorouracil was decreased. After NEAT1 interference, NEAT1 and KLF12 levels in BC cells treated with EVs were decreased, miR-141-3p expression was increased, cell proliferation, invasion, migration and in vivo metastasis were decreased, and drug resistance sensitivity was increased. NEAT1 can bind to miR-141-3p and upregulates KLF12 expression. No 33820555 Neat1 LncRNA Mus musculus Alzheimer Disease brain tissues Regulation[miR-124/BACE1 axis] qRT-PCR//Luciferase Report Assay//Western Blot NEAT1 was notably up-regulated and miR-124 was remarkably down-regulated in AD mouse model. Knockdown of NEAT1 or overexpression of miR-124 showed the protective effects on cellular AD model induced by Aβ. Moreover, miR-124 expression could be up- and down-regulated by suppression or overexpression of NEAT1, respectively. In addition, the expression of BACE1 was the potential functional target of miR-124. These findings suggested that NEAT1 might play a vital role in the development of AD by regulating miR-124/BACE1 axis. No 31014193 Neat1 LncRNA Mus musculus Neuralgia spinal cord regulation[NEAT1/miR-128-3p/AQP4 axis] qRT-PCR//Luciferase Report Assay//IHC//Western Blot SCI rats showed distinctly higher NEAT1 expression compared with that of the control group.NEAT1 affects AQP4 signaling pathway to alleviate the spinal cord injury-induced NP via promoting miR-128-3p expression. No 33373887 NALT1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Regulation[NOTCH signaling pathway] qRT-PCR//Western Blot//Transwell Assay NALT1 was the hub-lncRNA of blue module and was an independent risk factor for GC prognosis. NALT1 was overexpressed in GC and its expression was closely related to invasion and metastasis. The mechanism may involve NALT1 regulation of NOTCH1, which is associated with lncRNA in T cell acute lymphoblastic leukemia, through cis regulation, thereby affecting the expression of the NOTCH signaling pathway. No 31802831 NAALADL2-210 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 NEAT1 LncRNA Homo sapiens Arthritis, Rheumatoid blood Expression[highly expressed] qRT-PCR MALAT1, MEG3, NEAT1 were increased in PBMCs, plasma, synovial fluid (p < 0.05) of RA patients. No 33026292 MTHFD1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 MTAP-206 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MTA3-219 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MTA1 LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-24A) Expression[no-differently] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD18 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 MT1P3 LncRNA Homo sapiens Diabetes Mellitus, Type 2 By lncRNA array, we screened thousands of differentially expressed lncRNA in megakaryocytes from T2D patients and confirmed that lncRNA metallothionein 1 pseudogene 3 (MT1P3) was significantly upregulated in megakaryocytes from T2D patients than in healthy controls. Expression[highly expressed] qRT-PCR By lncRNA array, we screened thousands of differentially expressed lncRNA in megakaryocytes from T2D patients and confirmed that lncRNA metallothionein 1 pseudogene 3 (MT1P3) was significantly upregulated in megakaryocytes from T2D patients than in healthy controls. No 29617185 MT1JP LncRNA Homo sapiens Lung Neoplasms NSCLC cancer tissues Regulation[miRNA-423-3p/Bim Axis] Western Blot//ISH//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay MT1JP, miRNA-423-3p, and Bim expressions in NSCLC cancer tissues and those in adjacent cancer tissues were significantly different (P<0.01 or P<0.001) with increasing stage.The lncRNA MT1JP suppresses NSCLC biological activities by regulating the miRNA-423-3p/Bim axis. MT1JP, miRNA-423-3p, and Bim expressions in NSCLC cancer tissues and those in adjacent cancer tissues were significantly different (P<0.01 or P<0.001) with increasing stage.The lncRNA MT1JP suppresses NSCLC biological activities by regulating the miRNA-423-3p/Bim axis. No 31342947 MT1JP LncRNA Homo sapiens Retinoblastoma retinoblastoma cells Regulation[Wnt/β-Catenin pathway ] qRT-PCR The results revealed that MT1JP was down-regulated, while β-catenin was highly expressed in retinoblastoma cells.We demonstrated that MT1JP was a tumor suppressor by negatively modulating the activity of the Wnt/β-catenin signaling pathway in the development of retinoblastoma and might function as a prognostic biomarker and therapeutic target. No 30024609 MSTRG.926466.1 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MSTRG.91634.7 LncRNA Mus musculus Pulmonary Fibrosis silica-induced lung inflammation and fibrosis in mice Interaction(PINK1 ) In Vivo Experiment//RNA Pull-Down//Western Blot//FISH//qRT-PCR//ELISA//IHC//IF In this study, the decreased expression of a novel exosomal lncRNA MSTRG.91634.7 in silicosis patients was identified according to high-throughput sequencing. Then, this macrophage-derived exosomal lncRNA MSTRG.91634.7 could regulate the fibroblast's activation by targeting PINK1 in a co-culture system of THP-1 and MRC-5. Finally, the mouse was exposed to 3 mg/50 μL silica to set up the silicosis model. AAV-ov-Pink1 was intratracheally injected to overexpress PINK1 in mice lungs. Our results suggested that PINK1, the target protein of lncRNA MSTRG.91634.7, participated in restricting the silica-induced lung inflammation and fibrosis in mice. No 36309172 MSTRG.739926.2 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MSTRG.562314.2 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MSTRG.505966.1 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MSTRG.505964.56 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MSTRG.35002.1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Regulation[ BMP signaling pathway] qRT-PCR//RNA-seq Notably, the qPCR assay confirmed that KIAA0125 and MSTRG.35002.1 were significantly downregulated in both ES and LS colon tumor tissues compared with normal colon tissues. No 31043791 MSTRG.314430.5 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MSTRG.255299.33 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MSTRG.255299.32 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MSL3P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MSH5-SAPCD1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MSC-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression(highly expressed) Bioinformatics Analysis The MSC-AS1 level was elevated in gastric cancer tissues. An increased MSC-AS1 level was significantly correlated with T stage (odds ratio [OR] = 2.55 for T3 and T4 vs. T1 and T2), histological type (OR = 5.28 for diffuse type vs. tubular type), histological grade (OR = 3.09 for grade 3 vs. grades 1 and 2), TP53 status (OR = 0.55 for mutated vs. wild type), and PIK3CA status (OR = 0.55 for mutated vs. wild type) (all p < 0.05) by univariate logistic regression. No 34926534 MSC-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MSC-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Epigenetics(lower-methylated ) qRT-PCR//Bioinformatics Analysis Significant negative correlation was observed between 8 DElncRNAs-DMCs pairs. 3 (cg23614229, cg23957912, and cg11052780) DMCs and 4 (CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1) DElncRNAs were identified as high-risk factors for poor prognosis of PC patients. Overexpression of hypo-methylated CACNA1G-AS1, F11-AS1, and NNT-AS1 and down-regulation of hyper-methylated MSC-AS1 significantly lower the survival of PC patients and could be a potential prognostic and therapeutic biomarker. No 35715447 MSC-AS1 LncRNA Homo sapiens Melanoma melanoma tissues and cells Interaction(miR-330-3p/ YAP1 axis) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//CCK8//Luciferase Report Assay//ELISA//Colony Formation Assay Results showed that lncRNA MSC-AS1 was upregulated in melanoma tissues and cells. High expression of MAS-AS1 was positively correlated with a poor prognosis. Pull-down and luciferase reporter demonstrated that miR-330-3p specifically binds directly to YAP1 and MSC-AS1, respectively. MSC-AS1 promoted the expression of YAP1 by downregulating miR-330-3p. Results showed that lncRNA MSC-AS1 was upregulated in melanoma tissues and cells. High expression of MAS-AS1 was positively correlated with a poor prognosis. No 36206100 MSC-AS1 LncRNA Homo sapiens Laryngeal Neoplasms LC tissues Expression(highly expressed) qRT-PCR A ceRNA network composed of MSC-AS1, miR-429, COL4A1 and ITGAV was constructed. It was verified by RT-qPCR that the lncRNA and mRNAs in the ceRNA network were highly expressed in multiple LC tissues. No 33079247 MRTFB-212 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MRPL9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MRPL53-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MRPL48 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MRPL23-AS LncRNA Homo sapiens Carcinoma, Adenoid Cystic blood Expression[highly expressed] qRT-PCR "Moreover, MRPL23-AS1 levels were higher in exosomes isolated from the blood plasma of patients with SACC, and exosomal MRPL23-AS1 affected pulmonary microvascular endothelial cells in an ""exosomecrine"" manner. " No 32098781 MRPL23-207 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MTCO5P1 LncRNA Homo sapiens Arthritis, Rheumatoid keen synovial tissues Expression[highly expressed] qRT-PCR Results of RT-qPCR showed that the levels of lncRNAs MTCO2P12, KCNQ5-IT1 and RP11-83J16.1 were increased, whereas lncRNAs LINC00570, RP11-342M1.6, and REXO1L4P were decreased in RA patients compared to controls. No 32355550 MTHFD2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR The expression of circ-MTHFD2 in cancer tissues of NSCLC patients was higher than that in adjacent tissues (p<0.05), and there was no remarkable difference in the expression of circ-MTHFD2 before and after RNase R digestion (p>0.05). The area under the curve (AUC) of circ-MTHFD2 ROC was 0.701, with the cut-off value of 3.534, 90% sensitivity and 71% specificity. Circ-MTHFD2 expression was closely associated with smoking history, tumor size, tumor-node-metastasis (TNM) stage, lymph node metastasis, and recurrence in NSCLC patients (p<0.05). No 33015789 N4BP2L2-IT2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 904 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 MTHFS LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 n406498 LncRNA Homo sapiens Tuberculosis host peripheral blood Regulation PCR "LncRNAs TCONS_00001838 and n406498 have the potential to become new molecular markers for PTB, and the nomogram of ""LncRNA + EHR"" model is expected to be effective for the early clinical diagnosis of TB." "Furthermore, the nomogram showed good compliance in predicting the risk of TB and a higher net benefit than the ""EHR"" model for threshold probabilities of 0.2-1." No 35308365 n381234 LncRNA Homo sapiens Brain Injuries, Traumatic Brain tissues Expression[lower expressed] qRT-PCR//Microarray LncRNA and mRNA expression profiles were detected in three TBI and three control groups. Volcano plot filtering identified 99 differentially expressed lncRNAs (P < 0.05, fold change > 1.2) (Figure ​1A1A and ​andB).B). Among them, 43 lncRNAs were up-regulated and 56 lncRNAs were down-regulated. In the TBI group, n333955, n332943, n335470, ENST00000384390, and n341115 were the five most significantly up-regulated lncRNAs. While, TCONS_00018733-XLOC_008489, OTTHUMT00000076953, NR_029967, ENST00000433249, and n381234 were the five most significantly down-regulated lncRNAs (Table 3). Next, we compared mRNA expression profiles of the TBI group with the control group. No 30632503 n346372 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[highly expressed] qRT-PCR The results indicated that lncRNA?n346372 was upregulated in bladder cancer tissues compared with the matched adjacent normal tissues (P<0.05). Following a χ2 test with common clinical variables among the patients, the expression level of lncRNA?n346372 was demonstrated to be positively associated with advanced tumor stage and poor histological differentiation of bladder cancer. Kaplan?Meier survival analysis revealed that patients with high expression of n346372 were more likely to have a poor prognosis compared with patients with low n346372 expression. No 30365104 n341115 LncRNA Homo sapiens Brain Injuries, Traumatic Brain tissues Expression[highly expressed] qRT-PCR//Microarray LncRNA and mRNA expression profiles were detected in three TBI and three control groups. Volcano plot filtering identified 99 differentially expressed lncRNAs (P < 0.05, fold change > 1.2) (Figure ​1A1A and ​andB).B). Among them, 43 lncRNAs were up-regulated and 56 lncRNAs were down-regulated. In the TBI group, n333955, n332943, n335470, ENST00000384390, and n341115 were the five most significantly up-regulated lncRNAs. While, TCONS_00018733-XLOC_008489, OTTHUMT00000076953, NR_029967, ENST00000433249, and n381234 were the five most significantly down-regulated lncRNAs (Table 3). Next, we compared mRNA expression profiles of the TBI group with the control group. No 30632503 n335470 LncRNA Homo sapiens Brain Injuries, Traumatic Brain tissues Expression[highly expressed] qRT-PCR//Microarray LncRNA and mRNA expression profiles were detected in three TBI and three control groups. Volcano plot filtering identified 99 differentially expressed lncRNAs (P < 0.05, fold change > 1.2) (Figure ​1A1A and ​andB).B). Among them, 43 lncRNAs were up-regulated and 56 lncRNAs were down-regulated. In the TBI group, n333955, n332943, n335470, ENST00000384390, and n341115 were the five most significantly up-regulated lncRNAs. While, TCONS_00018733-XLOC_008489, OTTHUMT00000076953, NR_029967, ENST00000433249, and n381234 were the five most significantly down-regulated lncRNAs (Table 3). Next, we compared mRNA expression profiles of the TBI group with the control group. No 30632503 n333955 LncRNA Homo sapiens Brain Injuries, Traumatic Brain tissues Expression[highly expressed] qRT-PCR//Microarray LncRNA and mRNA expression profiles were detected in three TBI and three control groups. Volcano plot filtering identified 99 differentially expressed lncRNAs (P < 0.05, fold change > 1.2) (Figure ​1A1A and ​andB).B). Among them, 43 lncRNAs were up-regulated and 56 lncRNAs were down-regulated. In the TBI group, n333955, n332943, n335470, ENST00000384390, and n341115 were the five most significantly up-regulated lncRNAs. While, TCONS_00018733-XLOC_008489, OTTHUMT00000076953, NR_029967, ENST00000433249, and n381234 were the five most significantly down-regulated lncRNAs (Table 3). Next, we compared mRNA expression profiles of the TBI group with the control group. No 30632503 n332943 LncRNA Homo sapiens Brain Injuries, Traumatic Brain tissues Expression[highly expressed] qRT-PCR//Microarray LncRNA and mRNA expression profiles were detected in three TBI and three control groups. Volcano plot filtering identified 99 differentially expressed lncRNAs (P < 0.05, fold change > 1.2) (Figure ​1A1A and ​andB).B). Among them, 43 lncRNAs were up-regulated and 56 lncRNAs were down-regulated. In the TBI group, n333955, n332943, n335470, ENST00000384390, and n341115 were the five most significantly up-regulated lncRNAs. While, TCONS_00018733-XLOC_008489, OTTHUMT00000076953, NR_029967, ENST00000433249, and n381234 were the five most significantly down-regulated lncRNAs (Table 3). Next, we compared mRNA expression profiles of the TBI group with the control group. No 30632503 MYLK-AS1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1080 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 MYL6-216 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MYL6-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MYD88-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MYBL2 CircRNA Homo sapiens Multiple Myeloma blood Expression[lower expressed] qRT-PCR In the present study, we identified a MM-associated circular RNA (circRNA), circ-MYBL2, which was dramatically decreased in MM tissue and serum samples in comparison to normal samples. Low circ-MYBL2 level was closely correlated with high clinical stage and unfavorable outcome, and serum circ-MYBL2 had excellent accuracy in diagnosing MM. No 33058028 MVIH LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR GC tissues exhibited a higher lncRNA MVIH expression level than paired nontumoros tissues. High MVIH level was revealed to be associated with the T stage, tumor-node-metastasis (TNM) stage and lymphatic metastasis of GC. Specially, patients with high MVIH expression level showed significantly shorter overall survival rate and progression-free survival rate. Moreover, invasion depth, distant metastasis, TNM stage, and MVIH expression were identified as risk factors of GC poor prognosis on univariate Cox regression analyses. No 30880767 MVIH LncRNA Homo sapiens Leukemia, Myeloid, Acute Bone marrow samples of AML patients Expression[highly expressed] qRT-PCR LncRNA MVIH expression was increased in AML patients (median: 2.205 [1.221‐3.405]) compared to controls (median: 0.986 [0.544‐1.999]) (P < .001) (Figure ​(Figure1A).1A). No 31724217 MVIH LncRNA Homo sapiens Leukemia, Myeloid, Acute BMMCs Expression(highly expressed) IF Lnc-MVIH was upregulated in pediatric AML patients compared with controls (p < 0.001). In pediatric AML patients, lnc-MVIH was correlated with increased bone marrow blasts, less inv(16) or t(16;16) abnormity, and higher Chinese Medical Association (CMA) risk stratification (all p < 0.05), whereas its correlation with National Comprehensive Cancer Network (NCCN) risk stratification was not statistically significant (p = 0.098). As for prognosis, lnc-MVIH high expression patients presented with lower complete response rate to 1 course of induction therapy (61.5% vs. 79.7%, p = 0.024), shorter event-free survival (median 12.0 months vs. 22.0 months, p = 0.006), and overall survival (median 28.0 months vs. 42.0 months, p = 0.043) compared with lnc-MVIH low expression patients. As for prognosis, lnc-MVIH high expression patients presented with lower complete response rate to 1 course of induction therapy (61.5% vs. 79.7%, p = 0.024), shorter event-free survival (median 12.0 months vs. 22.0 months, p = 0.006), and overall survival (median 28.0 months vs. 42.0 months, p = 0.043) compared with lnc-MVIH low expression patients. No 33704838 MVIH LncRNA Homo sapiens Uterine Cervical Neoplasms CC primary tumor and marginal non-tumor tissue Expression(highly expressed) qRT-PCR The expression levels of MVIH were significantly higher in CC tumors as compared to marginal non-tumor samples (p < 0.0001). Overexpression of MVIH was significantly associated with younger age (p = 0.033), lymph node metastasis (p = 0.031), tumor invasion depth (p = 0.035), and squamous cell type of CC (p = 0.019). The ROC analysis for MVIH as a diagnostic biomarker revealed the respective sensitivity and specificity of 67.83 and 80. Overexpression of MVIH was significantly associated with younger age (p = 0.033), lymph node metastasis (p = 0.031), tumor invasion depth (p = 0.035), and squamous cell type of CC (p = 0.019). The ROC analysis for MVIH as a diagnostic biomarker revealed the respective sensitivity and specificity of 67.83 and 80. No 36471781 MUC20-OT1-314 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MTUS1-226 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MTRR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MTOR LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-10A) Expression[highly expressed] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD4 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 MTO1 CircRNA Homo sapiens Osteosarcoma tumor Interaction(miR-630) qPCR//PCR Circ-MTO1 was lower in tumor than in non-tumor tissues (p<0.001); meanwhile, its elevated tumor expression was correlated with less advanced Enneking stage (p=0.049), good neoadjuvant chemotherapy response (p=0.029), and longer disease-free survival (DFS) (p=0.047). In addition, tumor circ-MTO1 was negatively associated with miR-630 (r=-0.323, p=0.032). Circ-MTO1 was lower in tumor than in non-tumor tissues (p<0.001); meanwhile, its elevated tumor expression was correlated with less advanced Enneking stage (p=0.049), good neoadjuvant chemotherapy response (p=0.029), and longer disease-free survival (DFS) (p=0.047). No 34545623 MTO1 CircRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Interaction[miR-17-5p] qRT-PCR Circular RNA-mitochondrial tRNA translation optimization 1 expression was downregulated in tumor tissue compared with paired adjacent tissue (P < .001) in patients with prostate cancer. In addition, circ-MTO1 high expression independently predicted favorable DFS and OS. Besides, further in vitro experiments illustrated that circ-MTO1 inhibited proliferation (P < .05) and invasion (P < .05) as well as downregulated miR-17-5p expression in prostate cancer cells (P < .05). Circ-MTO1 high expression in tumor tissue was correlated with decreased pathological T stage (P = .001) as well as lower pathological N stage (P = .020). As for survival profiles, the DFS (P = .006) and OS (P = .018) were both longer in patients who had circ-MTO1 high expression compared with patients who had circ-MTO1 low expression. No 31713278 MTND5P15 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 723 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 MTND4P16 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1037 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 MTND2P12 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[lower expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 20 No 32547537 MTMR9LP LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MTMR6 CircRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR//circRNA-seq The top 5 up- and downregulated circRNAs in patients with are listed in Table IV. No 32765789 MTMR1 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 MTLN LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumors Expression(highly expressed) qRT-PCR LINC00116 expression was upregulated in lung cancer. Furthermore, we found that LINC00116 expression was correlated with pT factor, pN factor, pTNM stage, smoking history, differentiation, and Ki-67 labeling index (p < 0.05). In addition, Kaplan-Meier survival analysis showed that high levels of LINC00116 expression were associated with poorer overall survival (OS), progression-free survival (PFS) and first progression (FP) (p < 0.05) of lung cancer patients. No 35763382 NEAT1 LncRNA Homo sapiens Arthritis, Rheumatoid RA patients Interaction(microRNA-21 and microRNA-125a) qRT-PCR lnc-NEAT1 was elevated, but miR-21 and miR-125a were declined in RA patients compared with HCs (all p < 0.001); meanwhile, lnc-NEAT1 was negatively correlated with miR-21 and miR-125a (both p < 0.05) in RA patients. Besides, elevated lnc-NEAT1 but declined miR-21 and miR-125a were correlated with erythrocyte sedimentation rate (ESR) and C-reactive protein and the 28-joint Disease Activity-ESR score (all p < 0.05) in RA patients. Moreover, lnc-NEAT1 was declined from baseline to W12 in RA patients (p < 0.001). Additionally, lnc-NEAT1 at W12 was declined in response patients compared with non-response patients (p = 0.006), and also decreased in remission patients compared with non-remission patients (p < 0.001). No 34708894 NEAT1 LncRNA Homo sapiens Asthma blood Expression[highly expressed] qRT-PCR LncRNA NEAT1 expression was upregulated in asthma patients in exacerbation compared with HCs and asthma patients in remission, and receiver operating characteristic curve exhibited that it was of good value in distinguishing asthma patients in exacerbation from HCs (AUC: 0.869 (0.830-0.908)) and asthma patients in remission (AUC: 0.775 (0.724-0.825)). No 31876058 MRPL18 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NONHSAT094532.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT090546.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT083385.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT083001.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT060802.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT060108.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT053785 LncRNA Homo sapiens Carcinoma, Hepatocellular serum Expression[highly expressed] qRT-PCR The level of NONHSAT053785 was significantly increased in the serum of HCC patients and was higher in HCC patients with IM as compared to those without. No 32606762 NONHSAT052104.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT046699.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT037033.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT036782.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT033507.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT033488.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT032459.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT029132.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT022309.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT015292.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] qRT-PCR//Microarray There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT007744.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT004949.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT000612.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 None CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NOC2LP2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NNT-AS1 LncRNA Homo sapiens Breast Neoplasms Breast Cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR However, NNT-AS1 expression was significantly Expression[down-expression]-regulated in tumor tissues compared to ANCTs (expression ratio=0.51, P=0.01). NNT-AS1 expression was significantly higher in estrogen receptor (ER) negative samples, in comparison with ER positives (P=0.01). No 31210440 NNT-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[TGF-β signaling pathway] qRT-PCR//IHC High levels of NNT-AS1 were detected in HCC tissues by both RNAscope and real-time quantitative PCR (RT-qPCR) assays.In conclusion, this research identifies a novel mechanism by which NNT-AS1 impairs CD4 T cell infiltration via activation of the TGF-β signaling pathway in HCC. Importantly, the overall survival time of HCC patients who exhibited higher levels of NNT-AS1 expression was significantly shorter than that of HCC patients who had lower levels of NNT-AS1 expression (P = 0.0402). No 33426064 NNT-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Expression[highly expressed] qRT-PCR NNT-AS1 level was significantly elevated in CC tissues and cells, especially in DDP-resistant tumors and cell lines. No 32489326 NNT-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Epigenetics(hypo-methylated ) qRT-PCR//Bioinformatics Analysis Significant negative correlation was observed between 8 DElncRNAs-DMCs pairs. 3 (cg23614229, cg23957912, and cg11052780) DMCs and 4 (CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1) DElncRNAs were identified as high-risk factors for poor prognosis of PC patients. Overexpression of hypo-methylated CACNA1G-AS1, F11-AS1, and NNT-AS1 and down-regulation of hyper-methylated MSC-AS1 significantly lower the survival of PC patients and could be a potential prognostic and therapeutic biomarker. No 35715447 NMU LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NMRAL2P LncRNA Homo sapiens Stomach Neoplasms gastric tumor tissues and GC cell lines regulation[ACOT7 ] qRT-PCR//Western Blot NMRAL2P was downregulated in tumor tissues and GC cell lines.NMRAL2P activation suppresses ACOT7 expression in GC. No 32469171 NLRC4 LncRNA Homo sapiens Colorectal Neoplasms tumor tissues Expression(highly expressed) qRT-PCR//IHC CLAN was highly expressed in tumor tissues. And the expression level was not correlated with age, gender, differentiation, and location of CRC patients. Also, CLAN expression did not correlated with budding, LVI, and TILs. However, CLAN expression was strongly associated with lymph node metastasis and higher TNM stage. No 36301367 NLGN1-208 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 NONHSAT093693.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT101022.2 LncRNA Homo sapiens Lupus Erythematosus, Systemic SLE patients and healthy controls Expression [highly expressed] qRT-PCR The lncRNA NONHSAT101022.2 was significantly downregulated in SLE patients and was also significantly related to the activity and severity of disease. No 34150746 NKILA LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patients Regulation Bioinformatics Analysis We identified and independently verified the ATG (AL691432.2, MMP2-AS1, AC124067.2, CRNDE, ABALON, AL161431.1, NKILA) in NSCLC patients and found that immune regulation in the tumor microenvironment is closely related to this gene. No 34849558 NONHSAT101175.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT157258.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT156459.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT155673.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT154079.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT153797.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT153298.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT151833.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT151590.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT151524.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT150829.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT145806.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT142467.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT139219 LncRNA Homo sapiens Hemophilia A blood Expression[lower expressed] qRT-PCR A comparison between the hemophilia and non-hemophilia groups showed that the mean of transcript levels of two lncRNAs was significantly lower in hemophilia A samples compared to normal samples (5.52 in control & 1.25 in case, and 4.86 in control & 2.14 in case for NONHSAT139215 and NONHSAT139219, respectively) (p < .05; Figure 4(A,B)). Considering that the expression of lncRNAs was low in the case versus the control, thus the selected lncRNAs could be related to FVIII activity in Iranian hemophilia A patients. No 30758269 NONHSAT139215 LncRNA Homo sapiens Hemophilia A blood Expression[lower expressed] qRT-PCR A comparison between the hemophilia and non-hemophilia groups showed that the mean of transcript levels of two lncRNAs was significantly lower in hemophilia A samples compared to normal samples (5.52 in control & 1.25 in case, and 4.86 in control & 2.14 in case for NONHSAT139215 and NONHSAT139219, respectively) (p < .05; Figure 4(A,B)). Considering that the expression of lncRNAs was low in the case versus the control, thus the selected lncRNAs could be related to FVIII activity in Iranian hemophilia A patients. No 30758269 NONHSAT139199.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT135353.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT134002.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT128361.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT124124.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT119430.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT119086.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT117419.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT112964.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT112228.2 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues regulation[MiR-509-3-5p-NONHSAT112228.2 Axis] qRT-PCR//Luciferase Report Assay Interestingly, high-expression of NONHSAT112228.2 accompanied by low-expression of p21 was observed in lung cancer tissues and associated with lower overall survival.MiR-509-3-5p- NONHSAT112228.2 regulatory axis can inhibit the proliferation and migration of lung cancer cells. Interestingly, high-expression of NONHSAT112228.2 accompanied by low-expression of p21 was observed in lung cancer tissues and associated with lower overall survival. No 32141418 NONHSAT108675.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT108154.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT108048.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT107107.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT105845.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NLGN1-207 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 NKILA LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NEAT1 LncRNA Homo sapiens Sepsis serum regulation[miR-370-3p/TSP-1 axis] Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//ELISA The enrichment of NEAT1 was enhanced in sepsis patients and LPS-stimulated RAW 264.7 cells. LncRNA NEAT1 promoted the inflammation and apoptosis while restrained the proliferation of LPS-stimulated RAW 264.7 cells through the miR-370-3p/TSP-1 axis. No 31957847 NEAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung blood Expression[highly expressed] qRT-PCR Five lncRNAs (RMRP, NEAT1, TUG1, MALAT1, and H19) stably expressed in plasma. Differential expression analysis showed that RMRP and TUG1 had significantly lower expression levels in the NSCLC group than in the control group (P = 0.001, Figure 2A, Supplementary Table S2 ). In contrast, NEAT1 and MALAT1 had significantly higher expression levels in the NSCLC group than in the control group (P = 0.022 and 0.002, respectively, Figure 2A, Supplementary Table S2 ). The expression level of H19 showed no significant difference between NSCLC and control groups (P = 0.534, Figure 2A, Supplementary Table S2 ). No 33425713 NEAT1 LncRNA Homo sapiens Lung Neoplasms blood Mutation[rs2239895 ] qRT-PCR//Genotyping Our study found that the polymorphisms of two SNPs increased or decreased the risk of lung cancer were not obvious, but statistical significance in non-small cell lung cancer and lung squamous cell carcinoma can be observed. Compared with homozygous CC genotype carriers, the GC genotype of rs2239895 was positively related to the risk of lung squamous cell carcinoma (OR 1.805, 95% CI, 1.168-2.789, P = 0.008). Similarly, associations between rs2239895 and lung squamous cell carcinoma risk were found (CC + GC vs. GG, OR 1.668, 95%CI, 1.093-2.545, P = 0.018) in dominant model. In stratified analysis for age, rs2239895 GC genotype was observed to increase the risk of non-small-cell lung cancer compared with CC genotype (OR 1.562, 95%CI, 1.029-2.371, P = 0.036). No 31704150 NEAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[miR-193a-3p/KRAS] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot The impact of knockdown of both NEAT1 and its predicted downstream miR-193a-3p in CRC cells was examined here to delve into their interactions and mechanisms. Additionally, the target of miR-193a-3p, Kirsten rat sarcoma viral oncogene homolog (abbreviated as KRAS), was also predicted by bioinformatics algorithms. Small interfering RNA and antisense oligonucleotides that inhibit NEAT1, as well as overexpression or knockdown of miR-193a-3p, were adequately drawn upon to confirm that NEAT1 serves as a miR-193a-3p sponge or competing endogenous RNA, to impact miR-193a-3p's further functions, including modulating KRAS proteins, both in vitro and in vivo. No 30575330 NEAT1 LncRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR The expression levels of serum NEAT1 were significantly higher in CRC, especially in metastatic CRC, than in colorectal adenoma and healthy controls. In addition, serum NEAT1 could well differentiate metastatic CRC from non-metastatic CRC and CRC from colorectal adenoma or healthy controls. Moreover, the metastatic CRC cells secreted more NEAT1 than the control cells. Upregulation of serum NEAT1 was significantly associated with poor clinical outcome of CRC, and serum NEAT1 was identified as an independent prognostic factor for CRC. No 33173332 NEAT1 LncRNA Homo sapiens Osteoarthritis knee cartilages regulation[miR-543/PLA2G4A axis] Northern Blot//Western Blot//Flow Cytometry//qRT-PCR//RIP//FISH//Luciferase Report Assay High-expressed NEAT1 was detected in OA cartilage and chondrocytes. .In conclusion, NEAT1 could sponge miR-543 to induce PLA2G4A expression, inhibit chondrocyte proliferation and promote apoptosis. No 33040229 NEAT1 LncRNA Homo sapiens Osteoarthritis OA cartilage tissue regulation[NEAT1/miR-193a-3p/SOX5 axis ] qRT-PCR//Luciferase Report Assay We found that miR-193a-3p expression was downregulated, while NEAT1 and SOX5 were upregulated in OA cartilage tissue and chondrocytes. In conclusion, NEAT1/miR-193a-3p/SOX5 axis regulates cartilage matrix degradation in human OA. No 31868949 NEAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR The expression level of lncRNA NEAT1, H19, MALAT1, HOTAIR, DANCR, UCA1, and BCAR4 were significantly decreased, compared with that in adjacent noncancerous tissues (all P <.05). The expression level of lncRNA GAS5 was statistically significantly increased (P <.05). For the quantitative polymerase chain reaction (qPCR) assay, 8 kinds of lncRNAs were detected as a result of the GeXP assay. No 30423146 NEAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR Relative NEAT1 expression level was significantly increased in serum of HCC patients 4.7 (1.31-6.82) (p < .0001). No 31190421 NEAT1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder tissues Expression[lower expressed] qRT-PCR PV1 was down-regulated in tumor tissues compared with both ANCTs and normal controls (Expression ratios of 0.48 and 0.14; P values of 0.4 and <0.001 respectively). No 31054930 NEAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 209 OSCC patients Mutation(rs3741384) Genotyping Using multivariate Cox hazards regression analysis, a predictive role of NEAT1 rs3741384 GG and UCA1 rs7255437 TC+TT in a worse prognosis of OSCC was identified. No 33384238 NEAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck plasma of 28 cases with TNM I/II [early-stage squamous cell carcinoma (ESCC) group], 36 cases with TNM III/IV [advanced-stage squamous cell carcinoma (ASCC) group], 16 cases with dysplasia [oral premalignant lesion (OPL) group] and 16 healthy controls (H group) Regulation qRT-PCR//Microarray The expression level of ENST00000412740, NR_131012, ENST00000588803 and NR_038323 exhibited significant differences in the H, OPL, ESCC and ASCC groups (P<0.05). ROC curve and logistic regression analyses revealed that the diagnostic efficacy of the combined lncRNAs was more prominent than that of a single lncRNA, particularly in the ESCC and ASCC groups. No 33552289 NEAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck oral cancer cell lines Expression(lower expressed) qRT-PCR NEAT1 expression in oral cancer cell lines was lower than that in normal cells and was significantly downregulated in OSCC. NEAT1 upregulation reduced the survival rate of patients with OSCC. NEAT1 upregulation also reduced the survival rate of OSCC patients treated with chemotherapy and radiotherapy. No 35028059 NEAT1 LncRNA Homo sapiens Osteosarcoma tumour tissues Expression(highly expressed) Bioinformatics Analysis  The normalised data highlighted that the paraspeckles transcripts were highly abundant in osteoblastic OS cells, except NEAT1, which was highly expressed in myeloid cell 1 and 2 subpopulations. No 36507075 NEAT1 LncRNA Homo sapiens Parkinson Disease blood Expression[highly expressed] qRT-PCR We detected NEAT1 to be significantly up-regulated in PD patients in multiple comparisons. No 31953211 NEAT1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML patients Regulation(P53 and BCL-2) qPCR//Bioinformatics Analysis Our results showed that NEAT1 expression was significantly lower in AML patients compared to healthy controls (P-value < 0.05). While a significant correlation was observed between the expression levels of NEAT1 and PTEN genes in AML patients (P-value < 0.05), there was no correlation between the expression levels of NEAT1 with P53 and BCL-2 (P-value > 0.05). No 35231756 NEAT1 LncRNA Homo sapiens Glioma Glioma tissues Interaction[SRSF1] Western Blot//qRT-PCR//RIP//RNA-seq//Microarray//EdU Staining Importantly, we identified nuclear paraspeckle assembly transcript1 (NEAT1), an upregulated long non-coding RNA (lncRNA) in glioma, as a target of SRSF1. Mechanistically, we proved that SRSF1 bound to NEAT1 and facilitated its RNA stability. The positive correlation between SRSF1 and NEAT1 levels in cancers further supported the positive regulation of NEAT1 by SRSF1. No 31200124 NEAT1 LncRNA Homo sapiens Nasopharyngeal carcinoma nasopharyngeal carcinoma tissues Expression[highly expressed] qRT-PCR In our study, we found that the levels of NEAT1 expression were increased in NPC clinical tissue specimens, and associated with advanced M classification and clinical stages. Moreover, the Kaplan-Meier analysis suggested that the levels of NEAT1 expression were negatively associated with the overall survival of patients with NPC. No 30618186 NEAT1 LncRNA Homo sapiens Multiple Myeloma multiple myeloma tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//RNA-seq Underexpression of NEAT1 was confirmed in healthy donors; NEAT1 levels were also significantly reduced in MGUS patients compared to MM (Online SExpression[Expression[up-expression]-expression]plementary Figure S4). No 30213829 NEAT1 LncRNA Homo sapiens Multiple Myeloma bone marrow interaction[microRNA-125a] qRT-PCR lncRNA NEAT1 was upregulated in MM patients compared with healthy donors and presented with excellent value in distinguishing MM patients from healthy donors.lncRNA NEAT1 might interact with miR-125a, and serves as a novel biomarker for treatment response and survival profiles in MM, indicating its clinical value for MM management. Furthermore, lncRNA NEAT1 negatively associated with complete remission (CR), overall remission rate (ORR), progression-free survival (PFS), and overall survival (OS). No 32608537 NEAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Regulation Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining NEAT1 regulated levels of ACSL4 and proteins related to the ferroptosis and classical apoptosis pathways. Levels of ACSL4, SLC7A11, and GPX4 were decreased more by NEAT1 silencing plus erastin than by erastin alone. No 33730930 NEAT1 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues and cells Interaction(miR-186-5p/PTP4A1 axis) Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Transwell Assay NEAT1 and PTP4A1 were significantly upregulated in CCA tissues and cells, but miR-186-5p was downregulated. In conclusion, NEAT1 was involved in cell proliferation, migration and invasion in CCA, and the NEAT1/miR-186-5p/PTP4A1/PI3K/AKT axis indicated novel regulatory mechanisms and therapeutics for the treatment of CCA. NEAT1 expression was negatively correlated with the survival of CCA patients and has remarkable correlation with serum CA199 levels and lymph node metastasis. No 33502823 NEAT1 LncRNA Homo sapiens Alzheimer Disease AD patients Expression(highly expressed) qRT-PCR//RNA-seq We found that the NEAT1 and BC200 levels in the plasma of the AD patients were significantly higher compared with the control group (P=0.0021, p= 0.02, respectively).Besides, plasma level of BC200 discriminated the pre-clinical subjects from healthy controls with 83 % sensitivity and 66 % specificity. Besides, plasma level of BC200 discriminated the pre-clinical subjects from healthy controls with 83 % sensitivity and 66 % specificity. No 35949493 NEAT1 LncRNA Homo sapiens Alzheimer Disease Sixty-six AD patients Interaction(miR-27a-3p) qRT-PCR the serum NEAT1 level, SUVR, and cerebrospinal fluid NEAT1 and BACE1 levels were higher than those in the control group, and the moderate-to-severe group were higher than the mild group (all P < 0.05). Serum NEAT1 level in AD patients was positively correlated with SUVR, cerebrospinal fluid NEAT1 and BACE1 (r = 0.350, 0.606, 0.341, all P < 0.05);serum miR-27a-3p level was positively correlated with cerebrospinal fluid miR-27a-3p level (r = 0.695, P < 0.05), and negatively correlated with SUVR and cerebrospinal fluid BACE1 level (r = - 0.521, - 0.447, both P < 0.05). Serum NEAT1 level in AD patients was positively correlated with SUVR, cerebrospinal fluid NEAT1 and BACE1 (r = 0.350, 0.606, 0.341, all P < 0.05);serum miR-27a-3p level was positively correlated with cerebrospinal fluid miR-27a-3p level (r = 0.695, P < 0.05), and negatively correlated with SUVR and cerebrospinal fluid BACE1 level (r = - 0.521, - 0.447, both P < 0.05). No 35659599 NEAT1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] qRT-PCR The expression of NEAT1 was increased significantly in prostate cancer tissues, compared with adjacent normal prostate tissues (P < .001). NEAT1 expression was significantly associated with TNM stage (P = .005), lymph nodes metastasis (P = .005), distant metastasis(P = .003), and Gleason score (P = .001). Overall survival rate was significantly lower for prostate cancer patients with a high expression level of NEAT1 than those with a low NEAT1a expression level (P = .048). No 32481386 NEAT1 LncRNA Homo sapiens Prostatic Neoplasms FFPE tissues of PCa patients Expression(highly expressed) qPCR Plasma profiling revealed eight dysregulated lncRNAs, while microarray analysis revealed 717 significantly dysregulated lncRNAs, out of which only nuclear-enriched abundant transcript 1 (NEAT1) was commonly upregulated in plasma samples and FFPE tissues. NEAT1's individual validation revealed statistically significant upregulation (FC = 2.101, p = 0.009). Receiver operating characteristic (ROC) analysis showed an area under the curve (AUC) value of 0.7298 for NEAT1 (95% CI = 0.5812-0.8785), suggesting a relatively high diagnostic value, thus having a potential biomarker role for this malignancy. Receiver operating characteristic (ROC) analysis showed an area under the curve (AUC) value of 0.7298 for NEAT1 (95% CI = 0.5812-0.8785), suggesting a relatively high diagnostic value, thus having a potential biomarker role for this malignancy. No 33917553 NEAT1 LncRNA Homo sapiens Multiple Sclerosis peripheral blood Expression[highly expressed] qRT-PCR In the present study, we evaluated expression levels of three lncRNAs named Nuclear Paraspeckle Assembly Transcript 1 (NEAT1), P21 associated ncRNA DNA damage activated (PANDA) and Taurine-up-regulated gene 1 (TUG1) in peripheral blood of 50 relapsing-remitting MS patients and 50 matched healthy subjects. No 30114626 NEAT1 LncRNA Homo sapiens Multiple Sclerosis Th17 cells Expression(highly expressed) qRT-PCR The results showed an increase in the expression of NEAT1, KCNQ1OT1 and RORC and a decrease in the expression of FOXP3. In plasma, an upregulation of IL17 and a downregulation of TGFB inflammatory cytokines were detected. The dysregulated expression of these genes could be attributed to relapsing-remitting MS (RR-MS) patients and help us understand MS pathogenesis better. No 35266286 NEAT1 LncRNA Homo sapiens Ischemic Stroke blood Interaction[decreased miR-124 and miR-125a ] qRT-PCR lncRNA NEAT1 expression was elevated in patients with AIS compared with controls, and it had a good predictive value for AIS risk (area under the curve [AUC]: 0.804 [95% confidence interval [CI]: 0.763-0.845]). No 31721299 NEAT1 LncRNA Homo sapiens Sepsis Blood Regulation[Lnc-NEAT1/miR-124 axis ] qRT-PCR//ELISA Lnc-NEAT1 expression was increased while miR-124 expression was decreased in patients with sepsis compared to HCs, and both of them were able to distinguish patients with sepsis from HCs.Lnc-NEAT1/miR-124 axis correlates with increased sepsis risk, and associates with higher inflammation, deteriorative disease condition, and decreased survival in patients with sepsis. No 31393351 NEAT1 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR LncRNA NEAT1 was increased, but miR-125a was decreased in sepsis patients compared to HCs, and in ARDS sepsis patients compared to non-ARDS sepsis patients. No 32785981 NEAT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NEAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR NEAT1 has been significantly over-expressed in NSCLC tissues obtained from male subjects compared with the corresponding ANCTs (Relative expression (REx) = 3.022, P = 0.019) but not in female subjects (P = 0.975). No 30866866 NKILA LncRNA Homo sapiens Lung Neoplasms Lung cancer tissues,cell line Regulation[IL-11/STAT3 signaling] qRT-PCR//MTT The expression of NKILA was significantly down regulated in lung cancer tissues when compared to matched normal tissue. No 31934087 NEAT1 LncRNA Homo sapiens Breast Neoplasms 50 GC samples and 50 BC samples Interaction(XIST, hsa-miR-612, MTRNR2L8) qRT-PCR//Bioinformatics Analysis//Microarray Based on bioinformatics and experimental analyses, lncRNA NEAT1 have a significant down-regulation in the breast cancer samples with tumor size lower than 2 cm. Also, it has a significant high expression in the gastric cancer patients. Furthermore, NEAT1 have a significant interaction with XIST, hsa-miR-612 and MTRNR2L8. High expression of NEAT1 have a correlation with the lower survival rate of breast cancer samples and higher survival rate of gastric cancer patients. No 35581633 NKILA LncRNA Homo sapiens Colorectal Neoplasms CRC cell lines and tissues Expression[lower expressed] qRT-PCR The present study investigated the expression and clinical significance of the lncRNA nuclear factor-κB interacting long non-coding RNA (NKILA) in CRC. It was identified that NKILA was downregulated in six CRC cell lines and tissues (n=173). Low NKILA expression was significantly associated with a poor differentiation grade, larger tumor size and advanced Tumor-Node-Metastases stages. Further statistical analyses revealed that low NKILA expression predicted poor overall survival (OS) rate and progression-free survival (PFS) rate. In addition, low NKILA expression was determined as an independent risk factor for poor OS and PFS. Furthermore, NKILA exhibited a relatively high sensitivity and specificity compared with CEA and CA19-9 in the early diagnosis of CRC. The serum level of NKILA was positively correlated with the level in tissues. In addition, a decreased NKILA level in serum was revealed to be partially restored post-operatively. No 31423284 NKILA LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Regulation Bioinformatics Analysis Combined with the overall survival data, we established 6 six lncRNA-based signature to predict prognosis, which were LINC00896, AC007996.1, NKILA, AP003555.2, MIRLET7BHG, and AC009237.14. We found that the expression level of PD-L1 (CD274) and somatic mutations in the high-risk group were higher than those in the low-risk group. No 34790382 NKILA LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Expression [highly expressed] Survival Analysis In this study, autophagy-related mRNAs-lncRNAs were screened from lung adenocarcinoma and a co-expression network of autophagy-related mRNAs-lncRNAs was constructed by using The Cancer Genome Atlas (TCGA). The univariate and multivariate Cox proportional hazard analyses were used to evaluate the prognostic value of the autophagy-related lncRNAs and finally obtained a survival model composed of 15 autophagy-related lncRNAs. No 33987935 NKILA LncRNA Homo sapiens Retinoblastoma blood Expression[lower expressed] Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay NKILA and MALAT1 were low expressed in retinoblastoma, and AUC of LncRNA NKILA and MALAT1 was over 0.9. No 32894536 NKILA LncRNA Homo sapiens Spondylitis, Ankylosing blood Interaction[TGF-β1] qRT-PCR//ELISA In the present study we found that plasma lncRNA NKILA was expressed at higher levels in active ankylosing spondylitis patients than in healthy controls.Plasma levels of TGF-ß1 were also higher in active ankylosing spondylitis patients than in healthy controls. Levels of plasma lncRNA NKILA and TGF-ß1 were significantly and positively correlated in ankylosing spondylitis patients but not in healthy controls. Patients in the high lncRNA NKILA level group had significantly longer length of treatment and higher re-hospitalization rate at 3 years after discharge. No 31173579 NKILA LncRNA Homo sapiens Diabetes Mellitus 200 were subjects with T2DM and 200 were healthy subjects Expression(highly expressed) qRT-PCR Compared with healthy controls, patients with T2DM showed an overall increase in expression of lncRNAs NKILA, NEAT, MALAT1, and MIAT by 3.94-fold, 5.28-fold, 4.46-fold, and 6.35-fold, respectively. Among patients with T2DM, higher expression of lncRNA NKILA was associated with hypertension (p=0.001), smoking (p<0.0001), and alcoholism (p<0.0001). Among patients with T2DM, higher expression of lncRNA NKILA was associated with hypertension (p=0.001), smoking (p<0.0001), and alcoholism (p<0.0001). No 33436407 NIPSNAP3B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NIHCOLE LncRNA Homo sapiens Stomach Neoplasms eighty-three GC tissues Expression(highly expressed) qRT-PCR The significant downregulation of LINC00365 (66.3%) and RP11-354K4.2 (62.7%) were observed in GC samples; while the upregulation of LINC01389, RP11-138J23.1, TWIST1, MMP13, MAML1, CD44s, and SALL4 were found in 67.5%, 45.8%, 56.6%, 44.6%, 59%, 55.4%, and 62.7% tumors samples at the mRNA level, respectively. No 36208698 NIFK-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NIFK-AS1 LncRNA Homo sapiens Sars-Cov-2 Vaccination Breakthrough Infections 57 VBT and unvaccinated COVID-19 patients Expression(highly expressed) RNA-seq//Bioinformatics Analysis Further, out of the 12 lncRNA genes, 7 lncRNAs are reported to modulate immune/inflammatory responses in infectious diseases. Out of the 7 lncRNAs, LUCAT1, MALAT1, NEAT1 and GAS5 were downregulated in the VBT. LUCAT1 is a negative regulator of interferon response, and downregulation of LUCAT1 suggests an activated interferon response (30). MALAT1 is known to negatively regulate the immune response and positively regulate the inflammatory response in the infected individuals, therefore downregulation of MALAT1 in the breakthrough infection suggests an upregulated immune response and downregulated inflammatory response (31, 32). NEAT1 and GAS5 also act as pro-inflammatory lncRNAs, and their downregulation is an indicator of decreased inflammatory response in the VBT (33, 34). Amongst the upregulated lncRNAs, ROR1-AS1, UGDH-AS1 and LINC00273 were upregulated in the VBT. The upregulation of ROR1-AS1 and LINC00273 indicates a heightened immune response, whereas upregulation of UGDH-AS1 suggests a decreased disease severity possibly modulated by MOV10 and EDN1 (8). No 36466827 NFIA-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[lower expressed] qRT-PCR The relative expression results indicated that microRNAs such as MIR-191, MIR-213, MIR-122A had significantly higher expression and MIR-125B-1, MIR-125B-2, MIR-145 had lower expression in ER positive breast cancer compared to normal breast. No 30775882 NFATC3 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 NFASC-216 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 NEURL3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NEMF-207 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 NELL2-213 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 NELL2 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NEK9 LncRNA Homo sapiens Breast Neoplasms 73 patients diagnosed with breast cancer Expression(highly expressed) PCR The experimental results show that lncRNA ATB and Nek9 in 3 groups are significantly different, and group A> group B> group C (all P < 0.05). The expression of lncRNA ATB and Nek9 is closely associated with lymph node metastasis and TNM stage in breast cancer patients (P < 0.05). Besides, the Spearman correlation coefficient shows that lncRNA ATB and Nek9 are positively correlated with breast cancer incidence (P < 0.05). It is evident that lncRNA ATB and Nek9 are expressed at high levels in breast cancer patients and are positively correlated with the occurrence and development of the disease. The experimental results show that lncRNA ATB and Nek9 in 3 groups are significantly different, and group A> group B> group C (all P < 0.05). The expression of lncRNA ATB and Nek9 is closely associated with lymph node metastasis and TNM stage in breast cancer patients (P < 0.05). Besides, the Spearman correlation coefficient shows that lncRNA ATB and Nek9 are positively correlated with breast cancer incidence (P < 0.05). It is evident that lncRNA ATB and Nek9 are expressed at high levels in breast cancer patients and are positively correlated with the occurrence and development of the disease. No 35935324 NEF LncRNA Homo sapiens Osteoporosis, Postmenopausal blood Expression[lower expressed] qRT-PCR We showed that plasma lncRNA-NEF was downregulated and plasma IL-6 was upregulated in postmenopausal osteoporosis patients compared with healthy controls. No 31220986 NEDD8-MDP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NEDD4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NECAB1-206 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 NEAT1_2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Expression[lower expressed] qRT-PCR We found that NEAT1_2 and WEE1 were upregulated, and miR-101-3p was downregulated in HCC tissues, as well as HCC cell lines No 30488993 NEAT1_1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer T24, BIU-87 and EJ-1 cells Interaction(miR-3122/H3K79me3 ) qRT-PCR//RNA Pull-Down We picked up miRNA miR-3122, which substantially interacted with NEAT1.1, and found that histone H3K79me3 was reduced in bladder cancer T24, BIU-87 and EJ-1 cells after miR-3122 overexpression, and rescued by NEAT1.1 additional compensation. Nonetheless, we failed to find that miR-3122 could interfere with expression of H3K79 methyltransferase disruptor of telomeric silencing-1 like (DOT1L). Interestingly, we harvested histone 3 fished by biotin-labelled miR-3122, and validated this intercrossing using RNA immunoprecipitation. No 35687898 NEAT1 LncRNA Homo sapiens Stomach Neoplasms 484 gastric cancer patients and 484 controls in Chinese Han population Mutation [rs3825071 and rs7943779 ] qRT-PCR//Genotyping In the dominant model (GG), the genotypes AG + AA of rs3825071 and rs7943779 were associated with an increased risk of gastric cancer (OR = 1.72, 95%CI = 1.27-2.32 and OR = 1.63, 95%CI = 1.19-2.22). Individuals harboring ≥ 3 risk alleles have higher risk of gastric cancer (OR = 1.88, 95% CI = 1.26-2.80, P = 0.002). No 33464437 NEAT1 LncRNA Homo sapiens Stomach Neoplasms 50 GC samples and 50 BC samples Interaction(XIST, hsa-miR-612, MTRNR2L8) qRT-PCR//Bioinformatics Analysis//Microarray Based on bioinformatics and experimental analyses, lncRNA NEAT1 have a significant down-regulation in the breast cancer samples with tumor size lower than 2 cm. Also, it has a significant high expression in the gastric cancer patients. Furthermore, NEAT1 have a significant interaction with XIST, hsa-miR-612 and MTRNR2L8. High expression of NEAT1 have a correlation with the lower survival rate of breast cancer samples and higher survival rate of gastric cancer patients. No 35581633 NEAT1 LncRNA Homo sapiens Breast Neoplasms cell lines Regulation[NEAT1/miR-21/RRM2 axis] qRT-PCR//EdU Staining//Western Blot Altogether, our data indicated that NEAT1, miR-21, and RRM2 were upregulated in several BC cell lines.Overexpressed of miR-21 in MDA-MB-231 cells promote proliferation and migration. Besides, our results demonstrated that overexpressed of miR-21 upregulated the level of RRM2. Accordingly, miR-21/RRM2 might be a new diagnosis and treatment target of BC. No 31621912 NEAT1 LncRNA Homo sapiens Breast Neoplasms blood Interaction[NEAT1/miR-204] qRT-PCR We quantified each RNA in plasma samples of 63 BC patients and 10 healthy women by quantitative real-time PCR. In cell culture experiments, the influence of these noncoding RNAs (ncRNAs) on proliferation and apoptosis of BC cell line MCF-7 was examined. Plasma levels of H19 (P = 0.030), NEAT1 (P = 0.030), and miR-331 (P = 0.012) were deregulated in BC patients compared with healthy women. In both cohorts, the concentrations of H19 correlated with those of miR-675 (P = 0.0001). Higher H19 (P = 0.001) along with lower miR-675 (P = 0.007) levels and higher miR-204 (P = 0.017) along with lower NEAT1 (P = 0.030) levels were detected in plasma of HER2-positive patients compared with the other BC subgroups. Whereas the expression of HOTAIR was below the detection level, miR-331 levels correlated with nodal status (P = 0.002) and recurrence (P = 0.012). In cell culture experiments, a competitive impact on cell proliferation and apoptosis by these ncRNAs was also documented. Our findings describe a relationship of the plasma levels of H19/miR-675 and NEAT1/miR-204 in the different BC subtypes; in addition, they reveal an interplay between these lncRNAs and miRNAs in the regulatory network in MCF-8 cells, which should also be considered in the search for new diagnostic and therapeutic markers. No 30803129 NEAT1 LncRNA Homo sapiens Breast Neoplasms serum Expression(lower expressed) qRT-PCR//ELISA The serum levels of HOTAIR, PAI-1, and OPN were significantly higher in breast cancer patients compared to controls and fibroadenoma patients. The serum level of PVT1 was significantly higher in breast cancer patients than in the controls, while that of NEAT1 was significantly lower in breast cancer patients compared to controls and fibroadenoma patients. No 33670447 MRPL20-AS1 LncRNA Homo sapiens Sleep Apnea, Obstructive OSAS patients Regulation qPCR//RNA-seq We found that three lncRNAs were significantly dysregulated, of which MRPL20-AS1 was the most significant. In a larger cohort of 22 OSAS patients, MRPL20-AS1 was inversely correlated with the apnea-hypopnea index (AHI). This indicates that OSAS patients with higher AHI levels and therefore more severe OSAS had lower levels of MRPL20-AS1 in the blood. No 35988669 MRPL11 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MALAT1 LncRNA Homo sapiens tongue squamous cell carcinoma tongue tissues Expression[highly expressed] qRT-PCR The expression of MALAT1 was upregulated in tongue SCC, compared to normal tongue tissues. The expression level of MALAT1 was correlated to differentiation and stage of tongue SCC, and high MALAT1 expression was associated with low disease-free survival and overall survival rates. Moreover, advanced tongue SCC patients with high MALAT1 level had lower disease-free survival and decreased overall survival rate than patients with low MALAT1 level. No 32383096 MEG3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung peripheral blood and tissues Expression(lower expressed) RNA Pull-Down//Western Blot//Transfection//MTT//Luciferase Report Assay//Transwell Assay LncRNA MEG3 was low in peripheral blood and tissues, while miR-543 was high (P < 0.05); both had good diagnostic values for NSCLC (P < 0.05). LncRNA MEG3 was low in peripheral blood and tissues, while miR-543 was high (P < 0.05); both had good diagnostic values for NSCLC (P < 0.05). LncRNA MEG3 had a negative correlation with miR-543 (P < 0.05) and influenced the prognosis of NSCLC patients (P < 0.05). No 34399782 MEG3 LncRNA Homo sapiens Cerebral Hemorrhage Serum Interaction(MEG3/miR-181b and UCH-L1) qRT-PCR "In this study, we studied the lncRNA MEG3 and miR-181b expression in 30 patients with ICH who were admitted to the General Hospital of Xinjiang Military Command from January 2021 to May 2021 by quantitative polymerase chain reaction. Serum levels of UCH-L1 were detected by enzyme-linked immune sorbent assay, and disease severity was evaluated using the Glasgow Coma Scale. We also recorded ICH-related deaths in hospital.Our data indicated that lnc-MEG3, miR-181b, and UCH-L1 are likely involved in the pathophysiology of ICH, and could form the basis of future studies on potential targets for the treatment of traumatic CNS injuries. UCH-L1 could also find application in ICH management. Further studies on the plasma lncRNA-MEG3, miR-181b, and UCH-L1 levels in patients with ICH could yield novel biological targets for the prediction and treatment of ICH. " Our data indicated that lnc-MEG3, miR-181b, and UCH-L1 are likely involved in the pathophysiology of ICH, and could form the basis of future studies on potential targets for the treatment of traumatic CNS injuries. No 36128917 MEG3 LncRNA Homo sapiens Asthma blood Expression[lower expressed] qRT-PCR The expression of MEG3 was low in asthma patients (P<0.050), the diagnostic sensitivity and specificity for asthma were 79.83 and 66.40%, respectively (P<0.001), it was the lowest in mixed granulocytic asthma (P<0.050) and was negatively correlated with the course of disease (r=-0.666, P<0.001). No 32104286 MEG3 LncRNA Homo sapiens Arthritis, Rheumatoid blood Expression[highly expressed] qRT-PCR MALAT1, MEG3, NEAT1 were increased in PBMCs, plasma, synovial fluid (p < 0.05) of RA patients. No 33026292 MEG3 LncRNA Homo sapiens Spondylitis, Ankylosing blood Expression[lower expressed] qRT-PCR The results indicated that MEG3 was downregulated in ankylosing spondylitis patients compared with that in healthy controls. In addition, patients with higher expression levels of MEG3 had a shorter hospitalization time and a lower re-hospitalization rate within 2 years after discharge It was concluded that lncRNA MEG3 is downregulated in ankylosing spondylitis patients and is associated with disease activity, time of hospitalization and disease duration. No 30651794 MEG3 LncRNA Homo sapiens Spondylitis, Ankylosing AS patients interaction[targeting miR-146a] qRT-PCR//Luciferase Report Assay//RIP MEG3 was downregulated in AS patients, negatively correlated with the levels of IL-1β, IL-6, and TNF-α, and blocked the inflammatory response of AS. LncRNA MEG3 plays an anti-inflammatory role in AS partially through targeting miR-146a, which provides a potential new means for the treatment of AS patients. No 31894531 MEG3 LncRNA Homo sapiens Ischemic Stroke blood Expression[highly expressed] Flow Cytometry//qRT-PCR//Western Blot In vivo study showed that MEG3 increased significantly in the IS group (P=0.004), and its level remained stable within 3 to 48h after the onset of IS. Overall survival analysis showed that patients with higher MEG3 expression within 48h had a relatively poor prognosis (P＜0.001). No 31656272 MEG3 LncRNA Homo sapiens Leukemia, Promyelocytic, Acute 287 AML patients derived from The Cancer Genome Atlas (TCGA) Expression(highly expressed) qRT-PCR In the development set, MEG3 expression was significantly increased in APL than AML with AML1/ETO, other types of AML, and disease controls, which was consistent with the results from the database analysis. MEG3 expression in APL was associated with age (P = .0053) but did not correlate with other clinicopathological features (P > .05). No 33372415 MEG3 LncRNA Homo sapiens Glioma human cancer tissues Expression(lower expressed) RNA-seq Results showed that MEG3 expression was lower in most of the human cancer tissues than in the normal tissues. Survival analysis showed that the CNV level of MEG3 had significant correlation with overall survival (OS) and progression-free survival (PFS) compared with wild type in LGG. Lower MEG3 expression was related with poor prognosis. No 34220951 MEG3 LncRNA Homo sapiens ankylosing spondylitis 1 blood regulation[Let-7i/SOST Axis] RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay The expression levels of MEG3 and SOST were decreased and let-7i was increased in AS patients. Furthermore, SOST expression was positively regulated by MEG3, while was negatively regulated by let-7i. Our results revealed that lncRNA MEG3 promoted SOST expression to restrain the progression of AS by sponging let-7i, which provided a treatment target for AS. No 32793634 MEG3 LncRNA Homo sapiens Pituitary Neoplasms pituitary tissues regulation[MEG3/MIR-376B-3P/HMGA2 axis] qRT-PCR//Luciferase Report Assay//Western Blot MEG3 and MIR-376B-3P were decreased in patients with CNFPA, and their transcriptional levels were highly associated with invasive CNFPAs.This study offers a novel mechanism of an MEG3/MIR-376B-3P/HMGA2 regulatory network in CNFPAs, which may become a breakthrough for anticancer treatments. No 31899875 MEG3 LncRNA Homo sapiens childhood acute lymphocytic leukemia cALL patients Expression(lower expressed) qRT-PCR Lnc-MEG3 expression was decreased in cALL patients (vs. controls) (p < .001). Meanwhile, higher baseline lnc-MEG3 expression was correlated with good prednisone response at day 8 (p = .001) and good bone marrow response at day 15 (p = .046) in cALL patients. No 33600264 MEG3 LncRNA Homo sapiens childhood leukemia 266 patients with childhood ALL and 266 healthy controls Mutation(rs7158663 ) qRT-PCR//Genotyping MEG3 rs7158663 AG and AA genotypes were significantly associated with ALL [odds ratio=1.61 (95% confidence interval=1.12-2.31) and 2.21 (1.16-4.22), respectively]. The A allele also exhibited a statistical association with higher risk of ALL (p=0.0015). There was no positive association as for rs3087918, rs11160608 or rs4081134. Interestingly, a significant interaction between MEG3 rs7158663 and age (≥3.5 years) and gender (male) was found. No 34949657 MEG3 LncRNA Homo sapiens Behcet Syndrome BD and SLE patients Expression(highly expressed) qRT-PCR The current results demonstrate the upregulation of lncRNA MEG3 in BD but not SLE patients. Moreover, significant differences in RORγt and FOXP3 were found between BD and SLE patients. The present findings linked lncRNA MEG3 to BD activity scores as well as CRP levels. Finally, lncRNA MEG3 showed excellent diagnostic power for BD, in addition to adequate discriminative power that can be used to differentiate between BD and SLE. No 36155183 MEG3 LncRNA Homo sapiens Autism Spectrum Disorder MEG3, GAS5, CYTOR, UCA1 lncRNAs and CRYBG3 gene Expression(highly expressed) qRT-PCR Expression of MEG3 was remarkably higher in children with ASD when compared with controls (Posterior Beta = 2.919, SE = 0.51, P value < 0.0001). This difference was significant among male subgroups (Posterior Beta = 2.913, SE = 0.56, P value < 0.0001) as well as female subgroups (95% CrI for Beta = [0.29, 2.4], SE = 0.53, P value < 0.0001). Expression levels of other lncRNAs or CRYBG3 were not different between children with ASD and controls. Among children with ASD, the most robust correlations were found between GAS5/CYTOR, CYTOR/UCA1 and GAS5/UCA1 with correlation coefficients of 0.83, 0.83 and 0.73, respectively. Among controls, GAS5/UCA1, MEG3/UCA1 and GAS5/MEG3 pairs had the highest correlation coefficients (0.89, 0.84 and 0.80, respectively). ROC curve analysis revealed that MEG3 can distinguish children with ASD from controls with diagnostic power of 0.792 (P value < 0.0001). This value was higher among male subgroups (AUC = 0.84, P value < 0.0001) compared with female subgroups (AUC = 0.727, P value = 0.0727). No 34115273 MEG3 LncRNA Homo sapiens Lymphoma, Non-Hodgkin 175 patients and 175 healthy subjects Mutation(rs7158663) PCR Results demonstrated rs4848320 C > T and rs6726151 T > G of PAX8AS1 and rs7158663 of MEG3 play a potential role in the susceptibility of NHL and PAX8AS1 rs1110839 T > G variant was associated with decreased risk of NHL. No 35938744 MEG3 LncRNA Homo sapiens Ichthyosis Vulgaris homogenized psoriatic lesions Interaction(miRNA 21) qRT-PCR//ELISA Expression of MEG3 was significantly downregulated, while miRNA-21 was remarkably upregulated, ER stress proteins GRP78, ATF6, and caspase 3 all showed low levels in homogenized psoriatic lesions when compared to normal skin. miRNA 21 and MEG3 were identified as possible diagnostic markers for psoriasis vulgaris. No 36718302 MEG3 LncRNA Homo sapiens Stomach Neoplasms tumor samples Expression(lower expressed) qRT-PCR We observed upregulation of HOTAIR but downregulation of MEG3 in tumor compared to the non-tumor tissues. We also found a significant negative association between their expression levels and H. pylori positive status. However, only the expression level of HOTAIR was significantly associated with the size and stage of the tumor (P < 0.05). The ROC curve analysis revealed that the expression levels of MEG3 and HOTAIR might discriminate GC tumor and non-tumor tissues. No 35186192 MEG3 LncRNA Homo sapiens Respiratory Syncytial Virus Infections RSV‑infected patients and in BEAS‑2B cells infected with RSV Regulation(TLR4‑dependent p38 MAPK and NF‑κB signaling) qRT-PCR//Transfection//Western Blot The findings of the present study demonstrated that the expression level of lncRNA MEG3 was reduced in the NPA samples of RSV?infected patients and in BEAS?2B cells infected with RSV. In vitro transfection revealed increased mRNA expression levels of toll?like receptor 4 (TLR4), tumor necrosis factor?α (TNFα) and interleukin (IL)?8 following RSV infection in BEAS?2B cells. Additionally, ectopic expression of MEG3 reduced the expression level of TLR4, subsequently suppressing the mRNA expression levels of TNFα and IL?8, indicating the protective role of MEG3 in the process of RSV infection. It is of note, that RSV infection?induced p38 mitogen activated protein kinase (MAPK) and nuclear factor?κB (NF?κB) activation was partly abolished by overexpression of MEG3. No 29257348 Meg3 LncRNA Mus musculus Breast Neoplasms BC patients Mutation(rs7158663 ) qRT-PCR//Genotyping Frequencies of MEG3 rs7158663 GA/AA genotype and A allele were significantly higher in BC patients compared to the controls results showed that serum MEG3 levels were significantly lower, according to the presence of the A allele in different study groups while the expression of miR-182 and miRNA 29 were significantly elevated. No 34421993 Meg3 LncRNA Mus musculus Cholesterol Gallstone Sixteen mice Expression(highly expressed) In Vivo Experiment//qRT-PCR//RNA-seq Moreover, KDM4A was selected as a hub node in the PPI network, and lncRNA MEG3 was considered as a key lncRNA in the regulatory network. Additionally, the miR-107-5p/miR-149-3p/miR-346-3-MEG3 regulatory pairs and MEG3-PABPC4/CEP131/NUMB1 co-expression pairs existed in the regulatory network. The qRT-PCR analysis showed that KDM4A expression was increased, and the expressions of MEG3, PABPC4, CEP131, and NUMB1 were downregulated. No 33665015 MED13L-230 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MED1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 MEAT6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MCM3AP-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] qRT-PCR There was a significant overexpression of the lncRNAs in tumour tissues as compared with their adjacent non-tumour tissues (P < 0.001). No 32678686 MCM3AP-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues interaction[sponging miR-545] qRT-PCR//Cell Cycle Assay We found that MCM3AP-AS1 was upregulated in CRC and its high expression levels predicted poor survival of CRC patients.MCM3AP-AS1 may upregulate CDK4 by sponging miR-545 to induce G1 arrest in CRC cells. We found that MCM3AP-AS1 was upregulated in CRC and its high expression levels predicted poor survival of CRC patients. No 32982409 MCM3AP-AS1 LncRNA Homo sapiens Osteoarthritis synovial fluid Interaction[ miR-142-3p/HMGB1] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay We found that MCM3AP-AS1 was up-regulated in OA. Bioinformatics analysis showed that MCM3AP-AS1 may interact with miR-142-3p, which can inhibit the apoptosis of chondrocytes. In addition, over-expression of MCM3AP-AS1 and miR-142-3p failed to affect the expression of each other. Instead, MCM3AP-AS1 over-expression led to up-regulated expressions of HMGB1, which is a target of miR-142-3p. Lipopolysaccharide (LPS) treatment led to the up-regulated expressions of MCM3AP-AS1 in chondrocytes. In cell apoptosis assay, MCM3AP-AS1 and HMGB1 over-expression led to increased apoptotic rate of chondrocytes. MiR-142-3p over-expression played an opposite role and attenuated the effects of MCM3AP-AS1 over-expression. No 31836002 MCM3AP-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues regulation[MiR-34a] qRT-PCR//Cell Apoptosis Assay In this study, we showed that miR-34a was downregulated and MCM3AP-AS1 was upregulated in NPC. MiR-34a inhibits cell proliferation and induces apoptosis in human NPC by targeting MCM3AP-AS1. High expression level of MCM3AP-AS1 and low levels of miR-34a in NPC tissues predicted the poor survival. No 32606969 MCM3AP-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Expression[highly expressed] RNA Pull-Down//qRT-PCR//RIP//Luciferase Report Assay//ChIP MCM3AP-AS1 was highly-expressed in ccRCC and associated with poor patient survival. MCM3AP-AS1 was highly-expressed in ccRCC and associated with poor patient survival. No 32714856 MEG3 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical carcinoma tissues Expression[lower expressed] qRT-PCR//Microarray CACX is one of the most common cancer affecting women world-wide. Here, expression microarray analysis revealed 8 over-expressed transcribed pseudogenes (GBP1P1, HLA-DRB6, HLA-H, SLC6A10P, NAPSB, KRT16P2, PTTG3P and RNF126P1), down-regulated 7 lincRNAs (H19, MIR100HG, MEG3, DIO3OS, HOXA11-AS, CD27-AS1 and EPB41L4A-AS) and 6 snoRNAs (SNORD97, SNORD3A, SNORD3C, SNORD3D, SNORA12 and SCARNA9) as DEncGs (log2 fold-change ≥ ±1.0) in CACX. No 31229557 MEG3 LncRNA Homo sapiens Sepsis Plasma interaction[miR-21] qRT-PCR The lnc-MEG3 expression and lnc-MEG3/miR-21 axis were increased, while miR-21 expression was decreased in sepsis patients compared with HCs. Lnc-MEG3 might serve as a potential biomarker for the development, progression, and prognosis prediction of sepsis via interacting with miR-21. No 31907972 MCM2 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 MEG3 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR LncRNA MEG3 expression was increased in sepsis patients compared with HCs. No 32844492 METTL14 LncRNA Homo sapiens Coronary Disease 506 patients and 506 healthy subjects Interaction(rs4834698, rs17050450 ) Genotyping Our study showed that GAS5 rs17359906 (OR 2.32, p = 0.020) and rs75315904 (OR 0.41, p = 0.039) were related to the risk of CHD in females. ESR1 rs6927072 (OR 1.76, p = 0.007) and rs4870061 (OR 0.74, p = 0.036) correlated with CHD risk in age ≤ 60 years. GAS5 rs17359906 (OR 0.10, p = 0.032) and ESR1 rs3020308 (OR 2.73, p = 0.041) were associated with an increased susceptibility to CHD in smokers. We also found that METTL14 rs4834698 (OR 1.57, p = 0.044) and ESR1 rs4870061 (OR 0.62, p = 0.040) were associated with CHD susceptibility in non-drinkers. Besides, METTL14 rs17050450 (OR 0.48, p = 0.029) and ESR1 rs3853248 (OR 1.61, p = 0.018) had the susceptibility of CHD patients with diabetes. Our study indicated that GAS5/METTL14/ESR1 polymorphisms were associated with CHD risk, which might provide a new understanding of CHD in a Chinese population. No 35235104 MESTIT1 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[lower expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 MER11C LncRNA Homo sapiens Depressive Disorder, Major blood Expression[highly expressed] qRT-PCR Five were found to be differentially expressed in MDD patients compared to healthy subjects (Fig. 1, Supplemenatal Table 3): MER11C, PCAT1, PCAT29, RMRP, and Y5. Whereas the expression level of RMRP in MDD patients was significantly lower than in healthy subjects (p = 0.000227, U = 175), the expression levels of MER11C, PCAT1, PCAT29, and Y5 were significantly higher in MDD patients than in healthy subjects (MER11C: p = 0.0215, U = 262; PCAT1: p = 0.0183, U = 199; PCAT29: p = 0.00693, U = 165; Y5: p = 0.00665, U = 226). No 31351391 MEMO1-209 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MELTF-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MELK LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 MEIS1-AS2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MEG8 LncRNA Homo sapiens Myelodysplastic Syndromes bone marrow Expression[highly expressed] qRT-PCR//Microarray Of the functionally described lncRNAs, we detected the upregulation of H19, EMCN-IT1, WT1-AS, MEG8, and PVT1 and the downregulation of ST6GAL2-IT1 and U6. No 32977510 MEG3-202 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues,cell lines Expression[lower expressed] qRT-PCR//RNA-seq Subsequently, four lncRNAs (upregulated ENST00000433108; downregulated ENST00000598996, ENST00000524265 and ENST00000398461) and two mRNAs (upregulated CCNB1 and CDK1) in 64 pairs of BC and adjacent normal tissues and four BC cell lines were detected using reverse transcription?quantitative PCR and these results were consistent with the sequencing data. No 33000254 MEG-3 LncRNA Homo sapiens stomach carcinoma cell lines (HGC-27,BGC-823) Interaction[EMT regulation] qRT-PCR//MTT//IHC//Western Blot It was demonstrated that lncRNA‑MEG3 expression was Expression[down-expression]regulated in gastric carcinoma cells compared with normal gastric cells. Western blot analysis demonstrated that lncRNA‑MEG3 transfection inhibited the expression of anti‑apoptotic proteins B cell lymphoma-2 (Bcl‑2) and Bcl‑2‑like protein 2 and increased the expression of pro‑-apoptotic proteins caspase‑3 and caspase‑9 in gastric carcinoma cells. lncRNA‑MEG3 transfection Expression[Expression[up-expression]-expression]regulated the expression of epithelial marker E‑cadherin and inhibited the expression of mesenchymal markers vimentin and fibronectin in gastric carcinoma cells, which suggested that lncRNA‑MEG3 inhibited epithelial‑mesenchymal transition (EMT), which may subsequently inhibit progression in gastric carcinoma cells. The present study also revealed that lncRNA‑MEG3 transfection sExpression[Expression[up-expression]-expression]pressed tumor growth mainly by decreasing the expression of vascular endothelial growth factor and increasing the expression of Bcl‑2 in vivo. In conclusion, these results indicated that lncRNA‑MEG3 may regulate EMT‑associated signaling pathways and has the potential as a therapeutic target in gastric carcinoma. No 31524253 MEG3 LncRNA Homo sapiens Stomach Neoplasms blood Expression[lower expressed] qRT-PCR Our results showed that the H19 level was significantly (P = 0.008) elevated and MEG3 expression was significantly (P = 0.002) down-regulated in GC patients compared to healthy participants. No 30447342 MEG3 LncRNA Homo sapiens Stomach Neoplasms gastric cancer samples Expression(lower expressed) RNA-seq Expression levels of LINC-ROR, HOXA-AS2 and MEG3 lncRNAs have been lower in gastric cancer samples compared with nearby non-cancerous samples (Expression ratios = 0.26, 0.37 and 0.36; P values = 0.021, 0.015 and 0.032, respectively). Expressions of LINC-ROR and HOXA-AS2 were not associated with any clinical or pathological parameter. ROC curve analysis revealed that HOXA-AS2 and LINC-ROR could significantly differentiate between gastric cancer samples and nearby non-cancerous tissues (AUC values = 0.68 and 0.64; P values = 0.01 and 0.04, respectively). No 36299522 MEG3 LncRNA Homo sapiens Breast Neoplasms breast tumor tissue Regulation[miR-506/SP3/SP1/DNMT1/MEG3 ] qRT-PCR//Wound Healing Assay//Transwell Assay SP was upregulated while miR-506 and MEG3 were downregulated in breast tumor tissue compared to adjacent normal breast tissues. Our data reveal a novel axis of miR-506/SP3/SP1/DNMT1/MEG3 in regulating migration and invasion of breast cancer cell lines, which provide rationales for developing effective therapies to treating metastatic breast cancers. No 30386180 MEG3 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[lower expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 MEG3 LncRNA Homo sapiens Breast Neoplasms a cohort of Iranian breast cancer patients Expression(lower expressed) Other Expression levels of TP53, MEG3, CASC2 and PANDA were significantly lower in tumoral samples compared with non-tumoral samples (Posterior mean differences = -4.26, -1.66, -5.98 and -3.13, respectively; P values < 0.0001).Expression of CASC2 was higher in Her2 1+ cases compared with Her2 negative cases (Beta = 1.85, P value = 0.037). Expression levels of MEG3 and TP53 were lower in grade 2 samples compared with grade 1 (Beta = -1.86, P value = 0.006 and Beta = -2.24, P value = 0.003, respectively). No 35034894 MEG3 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines,blood Interaction[targeting ADAR1] CCK8//qRT-PCR//Flow Cytometry//Western Blot Significant decreased levels of MEG3 existed in CRC tissue, cell lines and serum.Western blotting was conducted on cells that were transfected to overexpress MEG3. From these blots, we were able to elucidate that ADAR1 protein expression in both HCT-116 (P < 0.01; Figure ​Figure5E)5E) and HT29 (P < 0.01; Figure ​Figure5F)5F) cells was elevated when MEG3 was expressed at higher levels. MEG3 levels were up-regulated in HCT-116 cells. CRC patients with down-regulated serum MEG3 levels had larger tumor sizes, and advanced clinical stages.The sensitivity and specificity of serum MEG3 levels in CRC detection was 0.667 and 0.875, respectively. Tumor size, T stages, and serum MEG3 levels are indie factors that produce an effect on CRC patients' prognosis. Kaplan‑Meier survival curves suggested that CRC patients with high levels of MEG3 had a remarkably better overall survival rate. No 31413531 MEG3 LncRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR Our data revealed that the expression levels of lncRNAs 91H, PVT-1 and MEG3 were significantly higher in plasma samples from CRC patients than in those from non-cancerous controls. No 30978169 MEG3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC patients Mutation(rs7158663 ) qRT-PCR The AA, GA+AA, and A alleles were associated with increased risk for HCC (adjusted odds ratio (OR) 11.84%, 95% CI 4.07-34.45, p < 0.0001; adjusted OR 3.18, 95% CI 1.79-5.67, p < 0.0001; and adjusted OR 2.87, 95% CI 1.91-4.34, p < 0.0001, respectively). MEG3 serum expression level was downregulated in HCC patients. The rs7158663 G > A polymorphism and downregulated MEG3 were significantly associated with larger tumor size and advanced disease stage. The mutant genotype and allele were linked to an increased risk in male patients and patients ≥ 50 years old. No 35049008 MEG3 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines and tumors Interaction(miR664a-3p/ADH4 Axis) qRT-PCR Maternally Expressed Gene 3 (MEG3) is an imprinted lncRNA that is reported to be downregulated in HCC (in both cell lines and tumors). Alcohol Dehydrogenase 4 (ADH4) is a well-known prognostic protein biomarker for predicting the survival outcomes of patients with hepatocellular carcinoma whose expression is regulated by miR-664a-3p, which is upregulated in HCC.In summary, our interaction analyses results predict the significance of the MEG3/miR-664a-3p/ADH4 axis, where MEG3 downregulation results in miR-664a-3p overexpression and the subsequential underexpression of ADH4 in HCC, as a novel axis of interest that demands further validation. No 36553522 MEG3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Mutation[rs11160608 ] Luciferase Report Assay//Genotyping A statistically significant increased risk was observed between rs11160608 and OSCC (Dominant model: adjusted OR = 1.36, 95% CI = 1.06-1.76, p = 0.017). Moreover, the effect of rs11160608 CC genotype with OSCC risk was much strong in drinkers than non-drinkers (adjusted OR = 1.79, 95% CI = 1.17-2.73, p = 0.007). Furthermore, the luciferase activity of rs11160608 A allele was lower than rs11160608 C allele by luciferase reporter assay. No 30947387 MEG3 LncRNA Homo sapiens Parkinson Disease blood Expression[lower expressed] qRT-PCR The relative expression of lncRNAs MEG3, NGF and BDNF levels of PD group were significantly lower than that of the control group, and NSE level was significantly higher than that of the control group (P < 0.05) No 33329296 MEG3 LncRNA Homo sapiens Uterine Cervical Neoplasms blood Expression[lower expressed] qRT-PCR The results of the present study revealed that the serum MEG3 expression in the OG was significantly lower than that of the CG (P<0.05). The area under the curve (AUC) of MEG3 in diagnosing cervical cancer was 0.844, the AUC in predicting mortality was 0.858, while that in diagnosing lymph node transfer was 0.707, and that in diagnosing FIGO staging was 0.791. The 5-year survival rate of the high-expression group was higher than that of the low-expression group (P=0.020). No 32934750 MEG3 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[highly expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 MEG3 LncRNA Homo sapiens Lupus Erythematosus, Systemic BD and SLE patients Expression(highly expressed) qRT-PCR The current results demonstrate the upregulation of lncRNA MEG3 in BD but not SLE patients. Moreover, significant differences in RORγt and FOXP3 were found between BD and SLE patients. The present findings linked lncRNA MEG3 to BD activity scores as well as CRP levels. Finally, lncRNA MEG3 showed excellent diagnostic power for BD, in addition to adequate discriminative power that can be used to differentiate between BD and SLE. No 36155183 MEG3 LncRNA Homo sapiens Diabetes Mellitus, Type 2 Brazilian population Interaction(rs7158663) Genotyping The rs3931283/PVT1 G/G and rs7158663/MEG3 G/G are associated with DKD and markers of renal function in T2DM patients from a Brazilian population. No 36565414 MEG3 LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 MEG3 LncRNA Homo sapiens Multiple Sclerosis blood Expression[lower expressed] qRT-PCR We detected a significant down-regulation in the expression of NR_003531.3 in MS patients No 31721530 MEG3 LncRNA Homo sapiens Multiple Sclerosis blood Expression[lower expressed] qRT-PCR Relative expressions of SPRY4-IT1, HOXA-AS2, LINC-ROR, and MEG3 were significantly lower in female MS patients compared with female healthy subjects. No 32578033 MEG3 LncRNA Homo sapiens Sepsis blood regulation[NF-κB signaling pathway] Flow Cytometry//qRT-PCR//ELISA//Western Blot The expression level of serum MEG3 in the sepsis group was significantly lower than that in the control group (P <0.05).Overexpression of MEG3 can inhibit LPS-induced macrophage apoptosis and secretion of inflammatory factors by inhibiting the activation of the NF-κB signaling pathway. No 33040826 MCM3AP CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 MBP-219 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 METTL26 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MALAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and adjacent tissues Expression[highly expressed] qRT-PCR The results showed that H19 and MALAT2 was significantly higher expression in CRC tissues than in the adjacent normal colorectal mucosa No 31232113 MALAT1 LncRNA Homo sapiens Colorectal Neoplasms Colorectal Cancer tissuses Mutation[rs664589 ] RNA Pull-Down//Genotyping//RIP//qRT-PCR//Luciferase Report Assay MALAT1 rs664589 CG/GG genotypes significantly increased the associated risk and decreased overall survival of patients with colorectal cancer compared with the CC genotype. In vitro and in vivo experiments showed that the rs664589 C to G mutation facilitated carcinogenesis and metastasis of colorectal cancer. Mechanistically, the miRNA miR-194-5p targeted MALAT1 for degradation in the nucleus in an Ago2-dependent manner; the rs664589 G allele altered the binding of MALAT1 to miR-194-5p, resulting in increased expression of MALAT1. Colorectal cancer cells and human tissues with the rs664589 CG/GG genotype expressed significantly higher MALAT1 than those with the rs664589 CC genotype. Multivariate Cox regression analysis showed that MALAT1 was a poor prognostic factor of colorectal cancer. In summary, MALAT1 with the rs664589 G allele demonstrates altered binding to miR-194-5p in the nucleus, leading to increased MALAT1 expression and enhanced colorectal cancer development. SIGNIFICANCE: These findings highlight the functional role of MALAT1 polymorphism in colorectal cancer metastasis and survival as well as the underlying mechanism. No 31311811 MALAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Interaction[sponging miR-101] CCK8//qRT-PCR//Flow Cytometry//Western Blot In this study, significantly increased Malat1 expression and autophagy activity were found in colorectal cancer tissues compared with the adjacent normal tissues. Above all, the inhibition of autophagy by 3-MA not only relieved the Malat1-induced cell proliferation but also promoted the Malat1-induced cell apoptosis. In addition, Malat1 was found to act as an endogenous sponge by directly binding to miR-101 to reduce miR-101. Furthermore, the suppressive effects of miR-101 on the autophagy, proliferation, and apoptosis of CRC were abolished by Malat1. No 31372165 MALAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulated[up-regulated] RNA Pull-Down//Northern Blot//Western Blot//RIP//qRT-PCR//IF//Luciferase Report Assay//RNA-seq//Transwell Assay Using RNA-sequencing technology, we found a significantly differential lncRNA expression pattern in postsurgical, recurrent primary, and metastatic sites, compared with primary sites of non-recurrent CRC patients (Fig. ​(Fig.1a,1a, Supplementary Data S1). As one of the differentially expressed lncRNAs, MALAT1 had higher expression levels in recurrent primary and metastatic sites, relative to non-recurrent primary tumors (Fig. ​(Fig.1b),1b), and this result was validated by real-time PCR in 124 CRC primary and metastatic tissues (Fig. ​(Fig.1c).1c). In addition, we discovered that CRC patients with lower MALAT1 expression in primary tumors had better prognosis with longer OS (overall survival) and DFS (disease-free survival) (Fig. 1d, e). No 31097689 MALAT1 LncRNA Homo sapiens Colorectal Neoplasms Regulation[YAP1-MALAT1-miR-126-5p axis ] IP//RNA Pull-Down//Luciferase Report Assay//ChIP MALAT1 was obviously expressed, with differential expression of 11 lncRNAs in HCT116 cells after transfection with siYAP1 or si-Ctl. Based on bioinformatics prediction, immunoprecipitation (IP), and chromatin immunoprecipitation (ChIP), the interaction of YAP1 with TCF4/β-catenin was regulated by MALAT1. Bioinformatics prediction, dual luciferase assay, RNA-IP, and RNA pull-down assay demonstrated that YAP1-induced MALAT1 promoted the expression of metastasis-associated molecules such as VEGFA, SLUG, and TWIST, by sponging miR-126-5p in CRC. These findings indicated that the YAP1-MALAT1-miR-126-5p axis could control angiogenesis and epithelial-mesenchymal transition in CRC, providing potential biomarkers and therapeutic targets for CRC. No 30531836 MALAT1 LncRNA Homo sapiens Colorectal Neoplasms Liver Metastatic Colorectal Cancer and adjacent non-cancer liver tissues Expression [highly expressed] PCR We first evaluated expression levels of several lncRNAs in eight excised liver metastases from primary colorectal cancers and found significantly upregulated lncRNAs HOTAIR and MALAT1 along with significantly downregulated LOC285194. A positive signature comprising of high HOTAIR/MALAT1 and low LOC285194 also correlated with progression to higher grade tumors.  No 34307387 MALAT1 LncRNA Homo sapiens Colorectal Neoplasms CRC and AP patients Mutation(rs3200401 ) qRT-PCR//ELISA Serum PVT1 and MALAT1 were upregulated in CRC and AP patients versus healthy controls, whereas, miRNA-186, miRNA-101 and E-cadherin were downregulated in CRC versus non-CRC groups. rs3200401CC genotype carriers showed higher E-cadherin levels than CC + CT carriers. rs3200401 was correlated with lymph node status. MALAT1 showed superior diagnostic potential for CRC and predicted CRC risk among non-CRC groups in the multivariate logistic analysis. PVT1, MALAT1, miRNA-186 and miRNA-101 levels were correlated with E-cadherin, tumor stage, lymph node and distant metastasis. No 34200314 MALAT1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues regulation[ β-catenin degradation] qRT-PCR In this study, MALAT1 and β-catenin were found to be overexpressed in tumor samples from 62 patients with colon cancer. In conclusion, MALAT1 is an oncogene in colon cancer, which inhibits β-catenin degradation by upregulating H3K27 trimethylation and repressing GSK-3β expression. No 32485228 MALAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR The expression level of lncRNA NEAT1, H19, MALAT1, HOTAIR, DANCR, UCA1, and BCAR4 were significantly decreased, compared with that in adjacent noncancerous tissues (all P <.05). The expression level of lncRNA GAS5 was statistically significantly increased (P <.05). For the quantitative polymerase chain reaction (qPCR) assay, 8 kinds of lncRNAs were detected as a result of the GeXP assay. No 30423146 MALAT1 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR The levels of serum HULC, MALAT1, Linc00152, PTTG3P, SPRY4-IT1, UBE2CP3, and UCA1 were significantly higher in HCC patients than in patients with benign liver diseases and healthy controls, whereas serum PTENP1 was significantly decreased in HCC patients compared with healthy participants. No 32733618 MALAT1 LncRNA Homo sapiens Urinary Bladder Neoplasms urinary exosomes Expression[highly expressed] qRT-PCR LINC00355, UCA1-203, and MALAT1 expression was significantly higher in TCC patients compared to controls (non-malignant or normal samples). However, UCA1-201 expression was significantly decreased in TCC patients compared with controls. No 30568497 MALAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Mutation(rs3200401,rs619586 ) qRT-PCR Furthermore, analyses of clinical datasets revealed that the MALAT1 expression level was upregulated in OSCC compared to normal tissues, especially in the betel quid-chewing population. No 34268119 MALAT1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissue Regulated[up-regulated] IHC These findings provide further insight into the expression pattern of MALAT1 and BACH1 in TNBC and suggest them as prognostic biomarkers for TNBC. No 31939443 MALAT1 LncRNA Homo sapiens Glioblastoma 85 primary pediatric and adult GB patients Expression(highly expressed) qRT-PCR Among the subgroups, MALAT1 was highly expressed in group A that had a single TERT mutation as compared to that in groups D and E (p = 0.001 and p < 0.001, respectively); further, high MALAT1 expression was associated with worse prognosis in patients with C228T mutation (p < 0.001). Among the subgroups, MALAT1 was highly expressed in group A that had a single TERT mutation as compared to that in groups D and E (p = 0.001 and p < 0.001, respectively); further, high MALAT1 expression was associated with worse prognosis in patients with C228T mutation (p < 0.001). No 34210246 MALAT1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Expression[highly expressed] qRT-PCR MALAT1 expression was upregulated in PTC tissues compared with paired corresponding noncancerous tissues. We also found that upregulated MALAT1 expression was correlated with tumor size, lymph node metastases (p = 0.011) and WHO disease stage. No 29987950 MALAT1 LncRNA Homo sapiens Gallbladder Neoplasms GBC tissues and cell lines Interaction[ABI3BP ] Microarray Microarray-based analysis initially provided data suggesting that the expression of MALAT1 was up-regulated while that of the ABI family member 3 binding protein (ABI3BP) was down-regulated in GBC tissues and cell lines. The results confirmed that the cancer prevention effects triggered by restored ABI3BP and depleted MALAT1 as evidenced by suppressed cell growth and enhanced cell senescence. MALAT1 was observed to down-regulate ABI3BP expression through recruitment of the enhancer of zeste homolog 2 (EZH2) to the ABI3BP promoter region while the silencing of MALAT1 or suppression of H3K27 methylation was observed to promote the expression of ABI3BP. Furthermore, GBC patients with high expression of MALAT1 indicated poor prognosis. No 31174563 MALAT1 LncRNA Homo sapiens Osteoporosis, Postmenopausal PMOP tissues and cell Expression(lower expressed) qRT-PCR Plasma MALAT1 expressions were significantly lower in patients with PMOP, compared with healthy controls. Plasma MALAT1 expressions were markedly decreased in patients with VF, compared with patients without fractures. Plasma MALAT1 expressions were negatively related to GSQ grading in patients with VF. No 35311990 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cell lines Interaction(IGF2BP2) Cell Proliferation Assay//qRT-PCR//In Vivo Experiment//Western Blot We identified that lncRNA MALAT1 is a target of IGF2BP2 in NSCLC. IGF2BP2 promotes MALAT1 stability in an m6A-dependent mechanism, thus promoting its downstream target autophagy-related (ATG)12 expression and NSCLC proliferation. No 35111811 MALAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues Expression[highly expressed] CCK8//Wound Healing Assay//Flow Cytometry//Transwell Assay MALAT1 expression was higher in LSCC tissues than in adjacent normal tissues (P < .05) MALAT1 expression was higher in LSCC tissues than in adjacent normal tissues (P < .05), and LSCC patients who carried highly expressed MALAT1 demonstrated poorer 5-year survival than ones with low MALAT1 expression (P < .05). No 31837057 MALAT1 LncRNA Homo sapiens Prostatic Neoplasms 579 patients with prostate cancer Mutation(rs1194338 ) Genotyping Moreover, individuals with at least one polymorphic A allele at MALAT1 rs1194338 in the PSA >10 ng/mL group were positively associated with node-positive prostate cancer.In conclusion, MALAT1 SNPs are significantly associated with the susceptibility to both advanced Gleason grade and nodal metastasis in prostate cancer. Our results show that patients with a polymorphic G allele at rs619586 had a significantly higher risk of being in an advanced Gleason grade group (AOR: 1.764; 95% CI: 1.011-3.077; p = 0.046). No 34574033 MALAT1 LncRNA Homo sapiens Diabetes Mellitus, Type 2 571 T2DM patients and 526 controls Mutation(rs3200401, rs619586 ) Genotyping We found that the CT + TT genotypes of the rs3200401 polymorphism were significantly associated with an increased risk of T2DM in Chinese Han population (OR = 1.77; 95% CI:1.35-2.33; Padjusted < 0.001), whereas MALAT1 rs619586 AG + GG genotypes were associated with a reduced risk of T2DM (OR = 0.67; 95% CI:0.48-0.94; Padjusted = 0.021). Subsequent stratified analysis showed that compared with the rs3200401 CC genotype, CT + TT genotypes were associated with an increased risk of T2DM in the male, female, age ≥ 65 years, and BMI ≥ 24 subgroups (OR = 1.68, 95% CI:1.10-2.56, Padjusted = 0.016; OR = 1.83, 95% CI:1.27-2.62, Padjusted = 0.001; OR = 1.86, 95% CI:1.38-2.52, Padjusted < 0.001; OR = 2.13, 95% CI:1.45-3.15, Padjusted < 0.001; respectively). Haplotype analysis showed that T-A-C haplotype had a 1.533-fold increased risk of T2DM (95% CI, 1.208-1.945, P < 0.001) and C-G-G was associated with a decreased risk of T2DM. No significant association was found between rs11227209 and T2DM risk (P > 0.05). No 36283602 MALAT1 LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 MALAT1 LncRNA Homo sapiens Multiple Sclerosis Expression[highly expressed] qRT-PCR//RNA-seq//Microarray We confirmed MALAT1 upregulation in two independent MS cohorts (1.5-fold increase; P < 0.01; 59 cases, 50 controls). No 30566690 MALAT1 LncRNA Homo sapiens Multiple Sclerosis blood Mutation[rs619586 and rs3200401 ] Genotyping The G allele of the rs619586 was significantly under-represented in MS patients compared with controls (OR (95% CI) = 0.65 (0.46-0.92), adjusted P value = 0.03). This SNP was associated with lower MS risk in dominant model (OR (95% CI) = 0.63 (0.43-0.91), adjusted P value = 0.03). The rs3200401 was not associated with MS risk in any inheritance model. Moreover, the A T haplotype (rs619586 and rs3200401, respectively) within MALAT1 was associated with MS risk. The current study provides additional evidences for contribution of MALAT1 in the pathogenesis of MS. No 30822187 MALAT1 LncRNA Homo sapiens Multiple Sclerosis blood Expression[highly expressed] qRT-PCR MALAT1 and lnc-DC were significantly increased in MS patients (P=0.004 and P=0.006, respectively) in comparison with controls. No 30514825 MALAT1 LncRNA Homo sapiens Retinoblastoma blood Expression[lower expressed] Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay NKILA and MALAT1 were low expressed in retinoblastoma, and AUC of LncRNA NKILA and MALAT1 was over 0.8. LncRNA NKILA and MALAT1 were associated with tumor size, classification and clinical grading in children with retinoblastoma. No 32894536 MALAT1 LncRNA Homo sapiens Melanoma Interaction[miR-34a ] RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//RNA-seq We demonstrated that miR-34a is negatively correlated with MALAT1 in melanoma cells and tumor specimens. Interestingly, MALAT1, which contains functional sequence-specific miR-34a-binding sites, regulates miR-34a stability in melanoma cells and in vivo. Importantly, MALAT1 was significantly enriched in the Ago2 complex, but not when the MALAT1-binding site of miR-34a was mutated. Furthermore, MALAT1 could be shown to regulate c-Myc and Met expression by functioning as a miR-34a sponge. Our results reveal an unexpected mode of action for MALAT1 as an important regulator of miR-34a. No 31101802 MALAT1 LncRNA Homo sapiens Endometrial Neoplasms endometrial cancer tissues Mutation[rs664589 C>G ] qRT-PCR//Genotyping We found that the MALAT1 rs664589 C>G polymorphism was significantly associated with endometrial cancer risk (heterogeneous: adjusted OR = 0.57, 95% CI = 0.34-0.93, P = .026; homogenous: adjusted OR = 3.74, 95% CI = 1.12-12.45, P = .032; and recessive: adjusted OR = 4.06, 95% CI = 1.22-13.48, P = .022). Stratified analysis further demonstrated that the MALAT1 rs664589 C>G polymorphism significantly increased the risk of endometrial cancer susceptibility in patients with no history of surgery, more deliveries, BMI between 25 and 29.9, and FIGO stages II-III. Compared with the wild-type GCG haplotype carriers, individuals with CGG haplotypes had a higher risk of developing endometrial cancer. No 31880028 MALAT1 LncRNA Homo sapiens Endometrial Neoplasms Serum and tissue samples Expression(lower expressed) RNA-seq At the same time, lncRNA sequencing results showed that when endometrial atypical hyperplasia continued to change, including LINC00511, PVT1, and IQCH-AS1 (downregulated), and only changed significantly in the endometrial dysplasia group, including MALAT1, CARMN (downregulated) and LINC00648, BISPR, LINC01534, and LINC00930 (upregulated). No 36510632 MALAT1 LncRNA Homo sapiens acute myocardial infarction blood Expression[highly expressed] qRT-PCR Out of the 10 lncRNAs tested, the mRNA level of lncRNA H19, MIAT and MALAT1 were significantly higher in AMI patients than in healthy control (2.3 ± 0.2 vs. 1.0 ± 0.1, p < 0.001, 1.5±0.1 vs. 1.0±0.1, p = 0.002, 1.8±0.2 vs. 1.0±0.1, p < 0.001, respectively). No 31302423 MALAT1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Interaction[SLAIN2] qRT-PCR//IHC Similarly, MALAT1 expression was upregulated in CRC samples as compared to paired normal controls from the dataset of Shanghai General Hospital (Fig. 7a). Importantly, MALAT1 was much higher in stage III-IV or relapse group patients as compared to stage I-II or non-relapse group, respectively (Fig. 7b and c). Also, high MALAT1 expression was positively associated with lymph node metastasis and distant metastasis (Table S3). No 30797712 MALAT1 LncRNA Homo sapiens Lung Neoplasms Chinese Northeast Han Population Mutation(Rs3200401 ) Genotyping The findings of the study showed that rs3200401 was significantly associated with the risk of non-small cell lung cancer (NSCLC) and lung squamous cell carcinoma (LUSC). Compared with homozygous CC genotype, CT heterozygous genotype decreased risk of NSCLC (Pa = 0.034) and LUSC (Pa = 0.025). Rs3200401 in lncRNA MALAT1 was associated with the susceptibility of non-small-cell lung cancer and lung squamous cell carcinoma. No 35928715 MBOAT2 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 MALAT1 LncRNA Homo sapiens Lung Neoplasms MALAT1 rs619586 gene Mutation(rs619586 A/G) Genotyping The MALAT1 rs619586 A/G genotype frequencies between patient and control groups were significantly different (P < .001), specifically, 83.85% vs 75.88% (AA), 15.60% vs 21.79% (AG), and 0.55% vs 2.32% (GG). When the homozygous genotype MALAT1 rs619586 AA was used as the reference group, AG (AG vs AA: adjusted odds ratio [OR] 0.65, 95% confidential interval [CI] 0.51-0.83, P = .001) and GG genotypes were associated with significantly decreased risk of lung cancer (GG vs AA: adjusted OR 0.22, 95% CI 0.08-0.59, P = .003). In the dominant model, MALAT1 rs619586 AG/GG variants were also associated with a significantly decreased risk of lung cancer (adjusted OR 0.61, 95% CI 0.48-0.78, P < .001). In the recessive model, when MALAT1 rs619586 AA/AG genotypes were used as the reference group, the GG homozygous genotype was also associated with significantly decreased risk for lung cancer (adjusted OR 0.24, 95% CI 0.09-0.64, P = .004). Hsa-miR-34b/c rs4938723 T > C, pri-miR-124-1 rs531564 C > G and hsa-miR-423 rs6505162 C > A SNPs were not associated with lung cancer risk. When the homozygous genotype MALAT1 rs619586 AA was used as the reference group, AG (AG vs AA: adjusted odds ratio [OR] 0.65, 95% confidential interval [CI] 0.51-0.83, P = .001) and GG genotypes were associated with significantly decreased risk of lung cancer (GG vs AA: adjusted OR 0.22, 95% CI 0.08-0.59, P = .003). In the dominant model, MALAT1 rs619586 AG/GG variants were also associated with a significantly decreased risk of lung cancer (adjusted OR 0.61, 95% CI 0.48-0.78, P < .001). In the recessive model, when MALAT1 rs619586 AA/AG genotypes were used as the reference group, the GG homozygous genotype was also associated with significantly decreased risk for lung cancer (adjusted OR 0.24, 95% CI 0.09-0.64, P = .004). Hsa-miR-34b/c rs4938723 T > C, pri-miR-124-1 rs531564 C > G and hsa-miR-423 rs6505162 C > A SNPs were not associated with lung cancer risk. Our collective data indicated that MALAT1 rs619586 A/G SNPs significantly reduced the risk of lung cancer No 33761627 MBOAT2 CircRNA Homo sapiens Cardiomyopathy, Hypertrophic blood Expression[lower expressed] qRT-PCR Serum expression levels of circRNAs DNAJC6, TMEM56 and MBOAT2 were downregulated in patients with HCM. No 31889077 MBNL1-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute patients Regulation Bioinformatics Analysis In the chemotherapy group, patients with low lncRNA-MBNL1-AS1 expression had significantly lower EFS and OS (60.0%, 8.6%) than patients with high lncRNA-MBNL1-AS1 expression (68.6%, 34.3%) (χ2=7.817, 10.880, all P<0.01). In the chemotherapy group, patients with low lncRNA-MBNL1-AS1 expression had significantly lower EFS and OS (60.0%, 8.6%) than patients with high lncRNA-MBNL1-AS1 expression (68.6%, 34.3%) (χ2=7.817, 10.880, all P<0.01). No 33789374 MATR3-221 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MATR3-214 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MARF1-210 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MARCKSL1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MARCHF8-207 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MAPT-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] qRT-PCR In our study we found that MAPT-AS1 is overexpressed in breast cancer but not in triple negative breast cancer (TNBC) MAPT was associated with survival time in breast cancer. No 30074401 MAPT-AS1 LncRNA Homo sapiens Breast Neoplasms TCGA and breast cancer cells Expression [highly expressed] qRT-PCR The qRT-PCR identified 5 lncRNAs with significantly differential expression in breast cancer cells based on the 9 lncRNAs of the prognostic model, and the results were consistent with the tissues. In order to further explore the prognostic value of the 9 lncRNAs, the Kaplan Meier curve was built to confirm the relationship between these lncRNAs and OS. In our analysis, a total of 6 of the 9 lncRNAs (USP30-AS1, ST7-AS1, VPS9D1-AS1, OTUB6DB-AS1, LINC01087, and MAPT-AS1) were identified. The results indicated that the 8 autophagy-related lncRNAs were correlated to the OS in breast cancer patients No 33614483 MAPKAPK5-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 MAPK13 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MAP3K11-206 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 MAP2K5 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 MAP2K4P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MANCR LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues Interaction[downregulating miR-122a] qRT-PCR//Transwell Assay MANCR was found to be upregulated in HCC and high expression level of MANCR in cancer tissues predicted poor survival of HCC patients. MicroRNA (miR)-122a was downregulated HCC and was inversely correlated with MANCR only in cancer tissues. MANCR overexpression resulted in downregulation of miR-122a, while miR-122a overexpression showed no obvious effects on MANCR expression. MANCR overexpression showed no significant effects on HCC cell proliferation but led to promoted cell migration and invasion. miR-122a overexpression led to inhibited migration and invasion of HCC cells and attenuated the effects of MANCR overexpression. No 31788100 MANCR LncRNA Homo sapiens Breast Neoplasms BC tumor tissues Expression(highly expressed) qRT-PCR DSCAM-AS1 and MANCR lncRNAs were significantly upregulated in BC tumor tissues compared with the adjacent nontumor tissues. No 33012018 MALAT1 LncRNA Homo sapiens Stomach Neoplasms 150 GC patients and 100 healthy controls Epigenetics(hypermethylated ) Bioinformatics Analysis H19 gene, H19C island, and MALAT1B island, as well as 20 CpG sites were hypermethylated in peripheral blood of GC patients compared with HCs; similar results were also found in female and male groups (P < .05 for all). The combination of H19c3, H19c4, MALAT1b12, and age, as well as the combination of H19b7, H19c1, H19c5, and age in the nomograms could distinguish GC patients from HCs in the female group and male group, respectively. No 34615385 MALAT1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[binding to miR-339-5p] qRT-PCR In the present study, the expression of MALAT1 in clinical samples of breast cancer tissues was found to be significantly up-regulated that was consistent with the result based on the dataset of the Cancer Genome Atlas (TCGA) at cBioportal. Furthermore, the combination of bioinformatics prediction with experimental verifications indicated that lncRNA MALAT1 can regulate BLCAP mRNA expression through binding to miR-339-5p. A negative correlation between overall survival and the expression of MALAT1 was statistically significant in the group of diagnosis age below 60 or in the group of infiltrating ductal carcinoma analyzed by TCGA database, which declared that MALAT1 might be a potentially useful prognostic factor. No 30683807 MALAT1 LncRNA Homo sapiens Breast Neoplasms Interaction[EEF1A1] ChIP//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Notably, MALAT1 bound to the promoter regulatory element of the translation elongation factor 1-alpha 1 gene EEF1A1. Knockdown of MALAT1 by shRNA caused significant downregulation of EEF1A1 in breast cancer MDA-MB231 and SKRB3 cells. Using a luciferase reporter assay, we showed that knockdown of MALAT1 reduced the promoter activity of EEF1A1 in these two breast cancer cells. Chromatin immunoprecipitation (ChIP) assay indicated that MALAT1 regulated EEF1A1 by altering the histone 3 lysine 4 (H3K4) epigenotype in the gene promoter. MALAT1 was overexpressed in breast cancer tissues and breast cancer cells. Knockdown of MALAT1 reduced cell proliferation and invasion by arresting cells at the G0/G1 phase. Ectopic overexpression of EEF1A1 reversed the altered tumor phenotypes induced by MALAT1 shRNA treatment. These data suggest an epigenetic mechanism by which MALAT1 lncRNA facilitates a pro-metastatic phenotype in breast cancer by trans-regulating EEF1A1. No 31105998 MALAT1 LncRNA Homo sapiens Breast Neoplasms cell line Expression[highly expressed] FISH//Wound Healing Assay//qRT-PCR Strand-specific detection of MALAT1 and TALAM1 shown that both lncRNAs are significantly upregulated in all breast cancer cell lines tested comparing to the non-tumorigenic cell line (Fig. ​(Fig.1a1a and Additional file 1: Figure S4). No 31382922 MALAT1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] qRT-PCR The data analyses revealed that MALAT1 was up-regulated in breast cancer and could be a distinctive factor to diagnose cancer. No 32880825 MALAT1 LncRNA Homo sapiens Breast Neoplasms Regulation Meta-analysis The results showed that MALAT1 had been widely studied in the proliferation and differentiation of cancer cells, and MALAT1 might regulate breast cancer through the PI3K/AKT/mTOR signaling pathway. In addition, high expression of MALAT1 had a significant correlation with relapse-free survival (HR: 1.51, 95% CI: 0.79-2.29), while there was no significant correlation between MALAT1 expression and overall survival (HR: 1.09, 95% CI: 0.63-1.72). No 35116487 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues Expression[highly expressed] qRT-PCR MALAT1and SOX9 expression was higher in NSCLC tissues than the adjacent tissues, and they have positive correlation. No 29896925 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Expression[highly expressed] qRT-PCR Our results indicated that MALAT1 and miR-197-3p were both over-expressed within NSCLC tissues and cells, when compared with normal tissues and cells (P < 0.05). No 30841025 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues Expression[highly expressed] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The results showed that miR-142-3p expression was reduced in NSCLC tissues, while β-catenin and MALAT1 expression levels were elevated. No 30970294 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung blood Expression[highly expressed] qRT-PCR Five lncRNAs (RMRP, NEAT1, TUG1, MALAT1, and H19) stably expressed in plasma. Differential expression analysis showed that RMRP and TUG1 had significantly lower expression levels in the NSCLC group than in the control group (P = 0.001, Figure 2A, Supplementary Table S2 ). In contrast, NEAT1 and MALAT1 had significantly higher expression levels in the NSCLC group than in the control group (P = 0.022 and 0.002, respectively, Figure 2A, Supplementary Table S2 ). The expression level of H19 showed no significant difference between NSCLC and control groups (P = 0.534, Figure 2A, Supplementary Table S2 ). No 33425713 MALAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Expression[highly expressed] Meta-analysis The overexpression of lncRNA MALAT-l in NSCLC tissues was correlated with OS, gender, tumor size, LNM, tumor differentiation, and TNM stage. Thus, lncRNA MALAT-l may serve as a prognostic factor for NSCLC. No 33052949 MALAT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Expression[highly expressed] qRT-PCR The expression levels of UCA1 and MALAT1 lncRNAs in ESCC tissues were significantly higher than those in adjacent carcinoma tissues, and there were statistically significant differences in TNM staging between the patients with high lncRNA expression and low lncRNA expression. The expression levels of UCA1 and MALAT1 lncRNAs in ESCC tissues were significantly higher than those in adjacent carcinoma tissues, and there were statistically significant differences in TNM staging between the patients with high lncRNA expression and low lncRNA expression. No 30002691 MALAT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma Mutation[rs3200401 C > T,rs619586 A > G] Genotyping Taken together, our findings proposed that polymorphism rs3200401 C > T in MALAT1 gene is associated with increased risk of ESCC. Since the association between rs619586 A > G polymorphism and ESCC risk was not significant after FDR adjustment, there was a minor possibility that rs619586 A > G might be a protective factor for ESCC. No 31040692 METTL25 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 METTL8-209 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MROH5 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR503HG LncRNA Homo sapiens cervical squamous cell carcinoma plasma Expression[lower expressed] qRT-PCR In this study, we observed that levels of miR503HG in plasma were significantly lower in CSCC patients than in healthy participants. No 32184661 MIR503 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 MIR497HG LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[lower expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 MIR4788 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR4672 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma plasma exosome Expression[highly expressed] qRT-PCR//RNA-seq Expression levels of the lncRNAs NR_039819, NR_036133, NR_003353, ENST00000442416.1, and ENST00000416100.1 were significantly higher in exosomes from ESCC patients than non-cancer controls. No 32597791 MIR4667 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR4537 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[highly expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 10 No 32547537 MIR4453HG LncRNA Homo sapiens Kidney Failure, Chronic blood Expression[highly expressed] qRT-PCR//RNA-seq Validation study in an independent cohort of ESRD patients (n = 111) confirmed that elevated plasma lncRNA DKFZP434I0714 is a significant independent predictor of adverse CV outcomes in uremic patients. Additional experiments demonstrated the functional involvement of DKFZP434I0714 in the pathogenesis of endothelial dysfunction. No 30097337 MIR4435-2HG-268 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MIR4435-2HG-257 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MIR4435-2HG-246 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MIR4435-2HG-242 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MIR4435-2HG-210 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MIR4435-2HG LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR4435-2HG LncRNA Homo sapiens Colorectal Neoplasms CRC samples Expression(highly expressed) In Vivo Experiment//qRT-PCR Microarray analysis revealed that lncRNAs SNHG6, MIR4435-2HG, and TRPM2-AS1 were upregulated in CRC.These results were validated in colon cell lines. Moreover, qRT-PCR showed that the expression levels of SNHG6 and TRPM2-AS1 were upregulated in the colorectal tumor tissues compared with their paired tissues. Nonetheless, there was no significant increase in MIR4435-2HG expression in CRC samples. No 34431156 MIR4435-2HG LncRNA Homo sapiens Colorectal Neoplasms CRC samples Expression(highly expressed) IP A markedly increased level of LINC00978 and β-catenin expression levels was observed in CRC samples compared with adjacent tissues (P < 0.0001).The results of Pearson's correlation coefficient highlighted a positive correlation between LINC00978 and β-catenin expression (r2 = 0.4695, P < 0.0001). No 34273360 MIR4435-2HG LncRNA Homo sapiens Osteoarthritis blood Expression[lower expressed] qRT-PCR MIR4435-2HG was downregulated in plasma of osteoarthritis than in plasma of healthy controls.Overexpression of MIR4435-2HG promoted, while MIR4435-2HG knockdown inhibited the proliferation of chondrocytes. In contrast, MIR4435-2HG overexpression inhibited, while MIR4435-2HG knockdown promoted the apoptosis of chondrocytes. No 31387631 MIR4435-2HG LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue regulation[MAPK/ERK pathway] Western Blot//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay LINC00978 expression was significantly up-regulated in human HCC tissue relative to adjacent normal tissue, and LINC00978 high expression was correlated with poor HCC overall survival.LINC00978 is highly expressed in human HCC tissue and correlates with poor HCC prognosis. LINC00978 promotes HCC cell proliferation, cell cycle progression, and survival, partially by activating the MAPK/ERK pathway. LINC00978 expression was significantly up-regulated in human HCC tissue relative to adjacent normal tissue, and LINC00978 high expression was correlated with poor HCC overall survival. No 32077915 MIR4435-2HG LncRNA Homo sapiens Carcinoma, Hepatocellular immune cell Interaction(MIR4435-2HG/miR-1-3p/MMP9/miR-29-3p/DUXAP8 ceRNA network axis) qRT-PCR Assessment of the MIR4435-2HG/hsa-miR-1-3p/MMP9/hsa-miR-29-3p/DUXAP8 ceRNA network axis in HCC showed that a high risk/poor prognosis was significantly correlated with tumor stage and invasion depth. No 35201491 MIR4435-2HG LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck plasma regulation[ upregulating TGF-β1] CCK8//qRT-PCR//Western Blot//Transwell Assay The results showed that levels of MIR4435-2HG and TGF-β1 in plasma were upregulated in OSCC.Therefore, MIR4435-2HG regulates the behaviors of OSCC cells by promoting the expression of TGF-β1. No 32016787 MIR4435-2HG LncRNA Homo sapiens ovarian carcinoma blood Interaction[TGF-β1] ELISA//Western Blot//PCR//Transwell Assay We found that both MIR4435-2HG and transforming growth factor beta 1 (TGF-β1) were Expression[up-expression]regulated in OC.Correlation analysis showed that plasma levels of MIR4435-2HG and TGF-β1 were positively correlated only in OC patients. qPCR and western blot analysis results showed that MIR4435-2HG overexpression led to Expression[up-expression]regulation of TGF-β1 in OC cells, while TGF-β1 treatment did not significantly affect MIR4435-2HG expression. Transwell invasion and migration assays showed that MIR4435-2HG and TGF-β1 promoted the invasion and migration of OC cells while TGF-β inhibitor sExpression[up-expression]pressed the invasion and migration of these cells. Further analysis of the Transwell invasion and migration assay results showed that TGF-β inhibitor reduced the effects of MIR4435-2HG overexpression. Expression[up-expression]regulation of MIR4435-2HG distinguished early stage (Stage I and II) OC patients from healthy controls. No 31435668 MIR4300HG LncRNA Homo sapiens Postoperative Nausea and Vomiting Mutation[ rs11232965] Genotyping//Microarray We identified a novel SNP (rs11232965) in the long non-coding RNA MIR4300HG that is associated with PONV. The rs11232965-SNP variant (T > C) is protective against the incidence of PONV. No 32928300 MIR4275 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 MIR3667HG LncRNA Homo sapiens Gallbladder Neoplasms GBC tissues and cells Expression(lower expressed) RNA-seq//Genotyping AC084082.3 and LINC00662 showed increasing expression levels (p-value = 0.009), while C22orf34 expression decreased in the sequence from gallstones to GBC (p-value = 0.04). No 35158906 MIR3654 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR329-1 LncRNA Homo sapiens Brain Injuries, Traumatic Brain tissues Expression[lower expressed] qRT-PCR//Microarray LncRNA and mRNA expression profiles were detected in three TBI and three control groups. Volcano plot filtering identified 99 differentially expressed lncRNAs (P < 0.05, fold change > 1.2) (Figure ​1A1A and ​andB).B). Among them, 43 lncRNAs were up-regulated and 56 lncRNAs were down-regulated. In the TBI group, n333955, n332943, n335470, ENST00000384390, and n341115 were the five most significantly up-regulated lncRNAs. While, TCONS_00018733-XLOC_008489, OTTHUMT00000076953, NR_029967, ENST00000433249, and n381234 were the five most significantly down-regulated lncRNAs (Table 3). Next, we compared mRNA expression profiles of the TBI group with the control group. No 30632503 MIR323B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma plasma exosome Expression[highly expressed] qRT-PCR//RNA-seq Expression levels of the lncRNAs NR_039819, NR_036133, NR_003353, ENST00000442416.1, and ENST00000416100.2 were significantly higher in exosomes from ESCC patients than non-cancer controls. No 32597791 MIR31HG LncRNA Homo sapiens Osteosarcoma OS tissues and OS cell lines Interaction[suppress miR-361] CCK8//Western Blot//Flow Cytometry//Transwell Assay MIR31HG was upregulated in OS tissues and OS cell lines. Mechanistically, cell growth and metastasis-related target genes of MIR-361 including VEGF, FOXM1 and Twist were de-repressed in OS cells by MIR31HG overexpression, leading to upregulated BCL2, CCND1 and epithelial-mesenchymal transition (EMT) phenotype. Patients with high expression of MIR31HG also showed more VEGF, FOXM1 and Twist levels. Overexpression of MIR31HG in vivo also promoted tumor growth via inhibition of miR-361 signals and elevated the expression of VEGF, FOXM1 and Twist for tumor growth. The patients with high expression of MIR31HG have high tumor stages and distant metastasis. No 31564967 MIR31HG LncRNA Homo sapiens Adenocarcinoma of Lung Expression[lower expressed] qRT-PCR "The results showed that CEBPA‐AS1 and GVINP1 were downregulated in LUAD tumor tissues, while MIR31HG and RAET1K were upregulated in LUAD tumor tissues (Figure 4). The qRT‐PCR results of these four lncRNAs were consistent with our TCGA bioinformatics results, indicating that our TCGA analysis was credible" No 30125988 MIR3142HG LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR503HG LncRNA Homo sapiens Arthritis, Rheumatoid peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR//RNA-seq In the present study, 231 upregulated and 110 downregulated lncRNAs were identified as differentially expressed in patients with RA compared with the controls. Information on the top 6 up- or downregulated lncRNAs is provided in Table III. No 33456537 MIR548AC LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR29B2CHG LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 903 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 MIR548AI LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MRGBP LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MPP2-209 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MPHOSPH9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MPHOSPH10 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 MPC1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MOCS2-DT-201 LncRNA Homo sapiens allergic asthma peripheral blood mononuclear cells Regulation qPCR ENST00000499459 and TCONS_00004989 are potential biomarkers for house dust mite-induced allergic asthma. No 36463267 MMP2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patients Regulation Bioinformatics Analysis We identified and independently verified the ATG (AL691432.2, MMP2-AS1, AC124067.2, CRNDE, ABALON, AL161431.1, NKILA) in NSCLC patients and found that immune regulation in the tumor microenvironment is closely related to this gene. No 34849558 MMP24OS-202 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[lower expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 18. No 31619123 MMP24OS LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MKRN5P LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 659 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 MKLN1 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 MITA1 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] Migration Assay//qRT-PCR//RNA-seq//Invasion Assay//ChIP Both RNA-seq (Fig. 1B) and QRT-PCR analyses (Fig. 1C) showed more than 5-fold upregulation of MITA1 by serum starvation. No 30839115 MIRLET7BHG LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Regulation Bioinformatics Analysis Combined with the overall survival data, we established 6 six lncRNA-based signature to predict prognosis, which were LINC00896, AC007996.1, NKILA, AP003555.2, MIRLET7BHG, and AC009237.14. We found that the expression level of PD-L1 (CD274) and somatic mutations in the high-risk group were higher than those in the low-risk group. No 34790382 MIRLET7BHG LncRNA Homo sapiens Leukemia TCGA(151 samples from 151 patients) Regulation Bioinformatics Analysis A four-autophagy related lncRNA (MIR133A1HG, AL359715.1, MIRLET7BHG, and AL356752.1) signature was established. The high risk score based on signature was related to the short survival time of AML patients. The signature was an independent factor for the prognosis for AML patients (HR = 1.684, 95% CI = 1.324-2.142, P < 0.001). A four-autophagy related lncRNA (MIR133A1HG, AL359715.1, MIRLET7BHG, and AL356752.1) signature was established. The high risk score based on signature was related to the short survival time of AML patients. The signature was an independent factor for the prognosis for AML patients (HR = 1.684, 95% CI = 1.324-2.142, P < 0.001). No 34276784 MIR99AHG-296 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MIR99AHG-253 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MIR99AHG LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR99AHG LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 MIR9-3HG LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR9-3HG LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck TCGA Regulation qRT-PCR Then, we recognized a set of six FElncRNAs PFLS (SLCO4A1-AS1, C1RL-AS1, PCED1B-AS1, HOXB-AS3, MIR9-3HG, and SFTA1P) for predicting patients' prognostic risks and survival outcomes. Notably, the low-risk group of the PFLS showed a higher MHC score and cytolytic activity (CYT) score than the high-risk group, implying the low-risk group may have greater tumor surveillance and killing ability.  No 34976018 MIR876 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 MIR762HG LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR762HG LncRNA Homo sapiens Breast Neoplasms TCGA Expression [lower expressed] Bioinformatics Analysis The high expression of four core lncRNAs (AC010595.1, AC046168.1, AC069277.1, and AP000904.1) was associated with worse overall survival, while the low expression of LINC00528 and MIR762HG was associated with worse overall survival. The 6-lncRNA model has an especially good predictive power for overall survival (p < 0.0001) and 3-year survival (the area under the curve = 0.980) in HER2-positive breast cancer patients. The high expression of four core lncRNAs (AC010595.1, AC046168.1, AC069277.1, and AP000904.1) was associated with worse overall survival, while the low expression of LINC00528 and MIR762HG was associated with worse overall survival. The 6-lncRNA model has an especially good predictive power for overall survival (p < 0.0001) and 3-year survival (the area under the curve = 0.980) in HER2-positive breast cancer patients. No 34257572 MIR6826 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 MIR6511B1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR614 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 MIR600HG LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR600HG LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Interaction(miR-144-3p/KIF3A) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay By qRT-PCR, it could be discovered in this study that MIR600HG expression obviously increased in CRC tissues and cell lines compared with the normal group. Overexpression of MIR600HG affected the expression of downstream molecules, such as miR-144-3p and KIF3A, providing the possible mechanisms of MIR600HG in the development and progression of CRC. Moreover, the high expression of MIR600HG was correlated with tumor size, tumor volume and TNM stage. No 35378445 MIR548H2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR29B2CHG LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR23AHG-201 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 MFAP3-209 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MIF-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cells Regulation[ lncMIF-AS1/miR-212-5p/NDUFA4 signal] Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay Expression of lncMIF-AS1 and NDUFA4 were upregulated in gastric cancer tissues and cells as compared with non-cancerous gastric tissues and cells (P < .05). Taken together, the present study implies that inhibition of lncMIF-AS1/miR-212-5p/NDUFA4 signal transduction may provide a promising therapeutic target for the treatment of gastric cancer. No 30238562 MICB-DT LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIAT LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)76) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 MIAT LncRNA Homo sapiens Stomach Neoplasms serum Expression[highly expressed] qRT-PCR Serum exosomal MIAT levels were significantly higher in GC patients than in gastric adenoma patients and healthy controls. Moreover, serum exosomal MIAT upregulation was significantly associated with worse clinical variables and shorter survival. No 32274858 MIAT LncRNA Homo sapiens Breast Neoplasms BC tissues regulation[DLG3] Wound Healing Assay//Co-IP//qRT-PCR//RIP//FISH//MTT//Transwell Assay MIAT was initially overexpressed while DLG3 was down-regulated in BC. Taken together, the central findings of our study demonstrate that MIAT silencing inhibits BC progression by means of up-regulating DLG3 via activation of the Hippo signaling pathway, highlighting a novel potential therapeutic target for the treatment of the BC. No 32593652 MIAT LncRNA Homo sapiens Breast Neoplasms BC tissues Expression(highly expressed) qRT-PCR The expression levels of MIAT were notably higher in BC than in normal or adjacent tissues. And MIAT expression could be used as a prognostic indicator of mortality risk in patients with BC in different aspects. And the high MIAT expression in serum was positive related to TNM stage (P = 0.032) and lymph node metastasis (P = 0.028). No 34712062 MIAT LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 MIAT LncRNA Homo sapiens Fatigue Syndrome, Chronic peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR LncRNAs NTT, MIAT and EmX2OS levels were found to be significantly elevated in ME/CFS patients as compared with healthy controls. No 30119681 MIAT LncRNA Homo sapiens acute myocardial infarction blood Expression[highly expressed] qRT-PCR Out of the 10 lncRNAs tested, the mRNA level of lncRNA H19, MIAT and MALAT1 were significantly higher in AMI patients than in healthy control (2.3 ± 0.2 vs. 1.0 ± 0.1, p < 0.001, 1.5±0.1 vs. 1.0±0.1, p = 0.002, 1.8±0.2 vs. 1.0±0.1, p < 0.001, respectively). No 31302423 MIAT LncRNA Homo sapiens tongue squamous cell carcinoma tongue tissue ,blood Regulation[Wnt/β-catenin signaling pathway] qRT-PCR Myocardial infarction associated transcript expression level in TSCC specimen was upregulated compared to adjacent non-neoplastic tongue tissue and had a significant positive association with its level in serum.Upregulated MIAT promoted EMT of TSCC cells through activation of Wnt/β-catenin signaling pathway and indicated a poor prognosis of TSCC, which may provide us a non-invasive approach to evaluate the prognosis of TSCC. MIAT levels in both TSCC specimen and serum were correlated with cervical lymph node metastasis and histological grading of TSCC patients. Results of survival analysis showed that high expression levels of MIAT in both TSCC tissues and serums indicated higher mortality and shorter survival time of TSCC patients. No 31166624 MIAT LncRNA Homo sapiens Coronary Artery Disease blood Expression[highly expressed] qRT-PCR The median MIAT expression level in CAD patients was significantly 12-fold higher than controls (p<0.001). No 31188931 MIAT LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[highly expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 MIAT LncRNA Homo sapiens Coronary Artery Disease blood Expression[highly expressed] qRT-PCR Compared with healthy donors, serum lncRNA-MIAT was significantly increased in CAD patients. No 31143478 MIAT LncRNA Homo sapiens Coronary Artery Disease Interaction(miR-29b-3p and miR-29b-3p/ PAPPA) qRT-PCR//ELISA//Luciferase Report Assay MIAT expression in CAD patients (4.23 [1.22-6.50]) was higher than that in non-CAD controls (1.64 [0.05-2.93]) (p < 0.01) and had an independent correlation with CAD. MIAT expression was positively correlated with the C-reactive protein level (r = 0.769, p < 0.0001) and pro-inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and IL-8 levels, while negatively correlated with the anti-inflammatory cytokine IL-10. LncRNA MIAT sponged miR-29b-3p and miR-29b-3p targeted PAPPA. No 34558803 MIAT LncRNA Homo sapiens beta-Thalassemia blood Expression[highly expressed] qRT-PCR Significant higher expression levels of the studied lncRNAs in β-thal patients compared to the controls (all P values < 0.001) were identified. No 30665334 MIAT LncRNA Homo sapiens Reperfusion Injury H9c2 cell Interaction(lncRNA MIAT/VEGFA pathway) In Vivo Experiment//qRT-PCR//Luciferase Report Assay//Western Blot In-depth studies revealed that HC83 directly downregulated a lncRNA known as myocardial infarction-associated transcript (MIAT) that led to a subsequent upregulation of VEGFA expression. No 36090756 MIAT LncRNA Homo sapiens Diabetes Mellitus 200 were subjects with T2DM and 200 were healthy subjects Expression(highly expressed) qRT-PCR Compared with healthy controls, patients with T2DM showed an overall increase in expression of lncRNAs NKILA, NEAT, MALAT1, and MIAT by 3.94-fold, 5.28-fold, 4.46-fold, and 6.35-fold, respectively. Expression of lncRNA MIAT was associated with only blurred vision (p<0.0001), smoking (p<0.0001), and alcoholism (p<0.0001). Expression of lncRNA MIAT was associated with only blurred vision (p<0.0001), smoking (p<0.0001), and alcoholism (p<0.0001). No 33436407 MIAT LncRNA Homo sapiens Hypertension, Pregnancy-Induced 69 pregnant women with gestational hypertension (GH) and 66 pregnant women with preeclampsia (PE) Expression(highly expressed) qRT-PCR The level of MIAT in GH group was significantly higher than that in HC group, while MIAT level in PE group was more significantly upregulated than that in GH group and HC group. ROC curve showed that MIAT had the ability to distinguish between GH patients and healthy controls. Pearson correlation coefficient suggested that HOTAIR expression was positively correlated with systolic blood pressure (SBP) and diastolic blood pressure (DPB). No 34652723 MIAT LncRNA Homo sapiens Coronary Artery Disease CAD patients Expression(highly expressed) qPCR MALAT1 and MIAT were upregulated in CAD patients (p Value= .0008 and .0078, respectively). The expression level of XIST was significantly elevated diabetic compared to non-diabetic CAD patients (p Value= .0003). MALAT1 gene had the highest diagnostic power for discrimination of CAD patients from controls (AUC= 0.682, p Value=.001). No 32447981 Miat LncRNA Mus musculus Atherosclerosis aortic tissues Regulation[PI3K/Akt signaling pathway] qRT-PCR//Western Blot//Tunel//H&E Staining MIAT was found to be upregulated in AS.Meanwhile, MIAT was determined to promote angiogenesis as well as the expression of inflammatory factors (IL-1β, IL-6, and TNF-α) in AS mice through the activation of the PI3K/Akt signaling pathway. Furthermore, MIAT activated the PI3K/Akt signaling pathway to participate in AS progression. No 31237148 Miat LncRNA Mus musculus Myocardial Infarction mouse model Expression(highly expressed) Other To shed light on this issue, we firstly detected the expression of lncR-MIAT using qRT-PCR and found a robust elevation (>5-fold) of lncR-MIAT level in heart of MI mice relative to sham-operated control counterparts. Similarly, 3-fold increase of lncR-MIAT was observed in cultured neonatal mouse ventricular cells (NMVCs) in response to hypoxic insult. No 33941765 Miat LncRNA Mus musculus Hypoxic-Ischemic striatal tissues Interaction[miR-211/GDNF] qRT-PCR//RIP//Western Blot Compared with control group, lncRNA MIAT and GDNF were downregulated in striatal tissues of neonatal rats in HI group and oxygen glucose deprivation (OGD)-induced ischemic injury of Neuro2A cells, whereas miR-211 was up-regulated in striatal tissues of HI group and OGD-induced ischemic injury of Neuro2A cells. LncRNA MIAT interacted with miR-211, and lncRNA MIAT overexpression reduced neuron apoptosis through miR-211. Besides, GDNF expression was positively regulated by lncRNA MIAT and negatively regulated by miR-211 in Neuro2A cells. In vivo experiment proved MIAT promoted motor function and relieved HI injury. No 30563429 Miat LncRNA Mus musculus Cardiovascular Diseases synovium and myocardial tissues of collagen-induced arthritis (CIA) mice. Expression [highly expressed] qRT-PCR//Transfection//ELISA//Western Blot Here, we firstly found that lncRNA myocardial infarction associated transcript (lncRNA MIAT), a crucial lncRNA to regulate CVD, expressed increasingly in synovium and myocardial tissues of collagen-induced arthritis (CIA) mice. No 33459112 MIA-RAB4B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIA2-AS1 LncRNA Homo sapiens Arthritis, Rheumatoid peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR The expression levels of NR_002819, NR_038935, and ENST00000603415 were significantly increased in the RA-ILD group, while the expression level of ENST00000560199 was significantly decreased. No 32133566 MHRT LncRNA Homo sapiens Mucocutaneous Lymph Node Syndrome serum Regulation qRT-PCR The results indicated that the serum levels of lncRNAs SRA and HCG22 were higher in patients with acute KD compared with those in healthy controls. B-type natriuretic peptide (BNP) and C-reactive protein were positively correlated with HCG22 in patients with acute KD, while total cholesterol and low-density lipoprotein were negatively correlated with HCG22 in patients with acute KD. No 34373708 MHENCR LncRNA Homo sapiens Colorectal Neoplasms tumor tissues and cells Interaction(MiR-532-3p) qRT-PCR//Luciferase Report Assay Compared with para-cancerous tissues, MHENCR expression was increased and miR-532-3p expression was decreased in tumor tissues. High expression of MHENCR exhibited shorter overall survival. No 36288952 MGC27345 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR MGC27345 expression levels were significantly decreased in GC tissues than in adjacent normal specimens. Lower expression of MGC27345 was found in advanced tumor stages. GC patients with low-expression of MGC27345 had a poorer overall survival compare to those with high-expression of MGC27345. Furthermore, MGC27345 was an independent protective prognosis factor in GC development. No 32767324 MGAT1 CircRNA Homo sapiens Heart Defects, Congenital CHD tissues regulation[ miR-34a/YAP1 axis] Flow Cytometry//qRT-PCR//RIP//PCR//IP The level of circMGAT1 was downregulated, while miR-34a was strikingly increased in CHD tissues and hypoxia-induced AC16 cells.In conclusion, circMGAT1 inhibited cell apoptosis and enhanced cell proliferation by regulating the miR-34a/YAP1 axis, providing a therapy target for the treatment of human CHD. No 33165436 MFAP5 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 MIF-AS1 LncRNA Homo sapiens Stomach Neoplasms 844 GC patients and 871 controls Mutation(rs17004044) Bioinformatics Analysis//Genotyping Significant associations were identified between MIF-AS1 rs17004044 variants and GC group in the codominant, dominant and additive models (OR = 2.843, P = 0.010; OR = 1.370, P = 0.004; and OR = 1.386; P = 0.001). In addition, association between rs17004044 variants and survival of GC was extremely observed (TC HR = 2.02 (1.21-3.37) P = 0.007, CC HR = 5.61 (2.12-14.83), P = 0.001). In addition, association between rs17004044 variants and survival of GC was extremely observed (TC HR = 2.02 (1.21-3.37) P = 0.007, CC HR = 5.61 (2.12-14.83), P = 0.001). No 35367937 MILIP LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues and cell lines regulation[miR-143-3p/SERPINE1 axis] qRT-PCR//Luciferase Report Assay//RIP MAFG-AS1 was upregulated in bladder cancer tissues and cell lines.Our findings indicated that MAFG-AS1 facilitates tumorigenesis via regulation of the miR-143-3p/SERPINE1 axis and also provides a novel insight into tumorigenesis and identify a promising therapeutic target for bladder cancer. High MAFG-AS1 expression was associated with bladder cancer histological grade, TNM stage and lymph node metastasis, and patients with high expression showed poor overall survival. No 35117325 MIR23AHG LncRNA Homo sapiens Head and Neck Neoplasms blood Expression[highly expressed] qRT-PCR LOC284454 was significantly upregulated in the sera of patients with nasopharyngeal carcinoma, oral cancer, and thyroid cancer. No 32972383 MILIP LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tumor tissue Expression(highly expressed) qRT-PCR Lnc-MAFG-AS1 expression was increased in HCC tumor tissue than in adjacent tissue [median (interquartile range): 2.730 (1.685-4.198) vs. 0.990 (0.703-1.468), p < 0.001], with a high area under the curve [0.889, 95% confidence interval (CI): 0.854-0.924] to distinguish them via receiver operating characteristic curve analysis. In addition, patients with a high expression of lnc-MAFG-AS1 exhibited worse overall survival than those with a low expression of lnc-MAFG-AS1 [median (95% CI): 34.0 (24.5-43.5) vs. 48.0 (41.5-54.5) months] (p = 0.011), which was further validated by univariate Cox's analysis [hazard ratio (HR) = 1.827, p = 0.013] and multivariate Cox's analysis (HR = 1.697, p = 0.040). No 36034393 Mir22hg-202 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 6. No 30974198 MIR216A LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 MIR210HG LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 MIR205HG-205 LncRNA Homo sapiens Urinary Bladder Neoplasms BC tissues,cell lines Expression[highly expressed] qRT-PCR//RNA-seq Subsequently, four lncRNAs (upregulated ENST00000433108; downregulated ENST00000598996, ENST00000524265 and ENST00000398461) and two mRNAs (upregulated CCNB1 and CDK1) in 64 pairs of BC and adjacent normal tissues and four BC cell lines were detected using reverse transcription?quantitative PCR and these results were consistent with the sequencing data. No 33000254 MIR205HG LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines Regulation[MIR205HG/SRSF1/KRT17 axis ] CCK8//qRT-PCR//RIP//EdU Staining//Transwell Assay LncRNA MIR205HG was a predicted overexpressed lncRNA in CESC tissues by employed the public database GEPIA (http://gepia.cancer-pku.cn/index.html), as exhibited in Fig. 2A. Then the overexpression of MIR205HG in cervical cancer cells was confirmed (Fig. 2B). In conclusion, MIR205HG modulated the biological activities of cervical cancer cells via targeting SRSF1 and regulating KRT17, which better understood the pathogenesis of cervical carcinoma and excavated a novel therapeutic target. No 31655037 MIR205HG LncRNA Homo sapiens lung squamous cell carcinoma LUSC samples Expression[highly expressed] CCK8//Colony Formation Assay//Flow Cytometry//Western Blot Our results showed that CTD-2562J17.6 and FENDRR were significantly downregulated while MIR205HG, LNC_000378, RP11-116G8.5, RP3-523K23.2, and RP5-968D22.1 were significantly upregulated in all five LUSC samples. Importantly, MIR205HG was upregulated in LUSC clinical samples as well as in LUSC cell lines. No 32188965 MIR205HG LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 MIR2052HG LncRNA Homo sapiens Breast Neoplasms 504 Chinese Han patients and 505 healthy controls Mutation(rs34841297) qRT-PCR//Luciferase Report Assay//Genotyping qRT-PCR results revealed that homozygous deletion (1.68±1.37) of the rs34841297 A- genotype resulted in higher MIR2052HG expression than the heterozygous deletion genotype (0.95±0.94) and wild AA genotype (0.26±0.12). No 34762068 MIR2052HG LncRNA Homo sapiens Abortion, Habitual MIR2052HG rs3802201 Mutation(rs3802201 C>G) Genotyping Our results showed that there was no evidence indicates the MIR2052HG rs3802201 C>G is related to RM (CG and CC: adjusted OR = 0.970, 95% CI = 0.694-1.355, p = 0.8577; GG and CC: adjusted OR = 0.743, 95% CI = 0.416-1.330, p = 0.3174; dominant model: adjusted OR = 0.925, 95% CI = 0.672-1.272, p = 0.6298; recessive model: adjusted OR = 0.751, 95% CI = 0.430-1.321, p = 0.3233). No 34910326 MIR196A1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 MIR17HG LncRNA Homo sapiens Glioma Mutation[rs7318578 ] Genotyping Our study firstly reported that MIR17HG rs7318578 was a risk factor for glioma susceptibility and rs17735387 was associated with the longer survival of glioma among Chinese Han population, which might help to enhance the understanding of MIR17HG gene in gliomagenesis. In subsequent studies, we will continue to collect samples and follow up to further validate our findings and further explore the function of these MIR17HG SNPs in glioma in a larger sample size. No 33036577 MIR17HG LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 775 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 MIR17HG LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 MIR155HG LncRNA Homo sapiens Glioma TCGA dataset Epigenetics(methylation ) qRT-PCR//Luciferase Report Assay//ChIP MIR155HG was predominantly expressed in the isocitrate dehydrogenase (IDH) wild-type as well as mesenchymal subtype gliomas. Promoter methylation levels of MIR155HG in glioblastoma (GBM) were remarkably decreased compared with those in lower-grade glioma (LGG). In addition, there were negative correlations between promoter methylation levels and MIR155HG expressions but positive correlations with patients' overall survival. In vitro studies further revealed that MIR155HG expression was regulated by DNA promoter methylation and transcription factor (SP1) binding to the promoter. Moreover, there was a close association between MIR155HG expression and immune as well as stromal cell infiltrations, inflammatory activities, and immune checkpoints. Clinically, univariate and multivariate Cox analyses revealed that MIR155HG is an independent prognostic marker for glioma patients. No 35299997 MIR137HG LncRNA Homo sapiens Urinary Bladder Neoplasms cell lines Expression[highly expressed] qRT-PCR As shown in Figure 8A and ​andB,B, the expression of 4 lncRNAs (MIR137HG, LINC00525, ERVH48-1 and LINC00518) was upregulated, while the expression of AC110491.1 and ADAMTS9-AS1 was downregulated in MIBC tissues and bladder cancer cells (T24, J82, UM-UC-3, TCCSUP and SW780) compared with the expression in adjacent nontumor bladder tissues and the immortalized SV-HUC-1 uroepithelial cells, respectively. No 31308745 MIR133A1HG LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[lower expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 12 No 32547537 MIR133A1HG LncRNA Homo sapiens Leukemia TCGA(151 samples from 151 patients) Regulation Bioinformatics Analysis A four-autophagy related lncRNA (MIR133A1HG, AL359715.1, MIRLET7BHG, and AL356752.1) signature was established. The high risk score based on signature was related to the short survival time of AML patients. The signature was an independent factor for the prognosis for AML patients (HR = 1.684, 95% CI = 1.324-2.142, P < 0.001). A four-autophagy related lncRNA (MIR133A1HG, AL359715.1, MIRLET7BHG, and AL356752.1) signature was established. The high risk score based on signature was related to the short survival time of AML patients. The signature was an independent factor for the prognosis for AML patients (HR = 1.684, 95% CI = 1.324-2.142, P < 0.001). No 34276784 MIR124-1HG LncRNA Homo sapiens Glioma glioma tissues,cell lines Expression[lower expressed] qRT-PCR//Transwell Assay//Western Blot Moreover, we confirmed levels of LINC00599 expression were decreased in glioma tissues and cell lines compared with matched adjacent normal tissues and normal human astrocytes (NHAs), respectively. No 30867254 MIR1227 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 MIR1-1HG LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[lower expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 11 No 32547537 MIR100HG-272 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 MIR100HG LncRNA Homo sapiens Uterine Cervical Neoplasms cervical carcinoma tissues Expression[lower expressed] qRT-PCR//Microarray CACX is one of the most common cancer affecting women world-wide. Here, expression microarray analysis revealed 8 over-expressed transcribed pseudogenes (GBP1P1, HLA-DRB6, HLA-H, SLC6A10P, NAPSB, KRT16P2, PTTG3P and RNF126P1), down-regulated 7 lincRNAs (H19, MIR100HG, MEG3, DIO3OS, HOXA11-AS, CD27-AS1 and EPB41L4A-AS) and 6 snoRNAs (SNORD97, SNORD3A, SNORD3C, SNORD3D, SNORA12 and SCARNA9) as DEncGs (log2 fold-change ≥ ±1.0) in CACX. No 31229557 MIR000378HG LncRNA Homo sapiens lung squamous cell carcinoma LUSC samples Expression[highly expressed] CCK8//Colony Formation Assay//Flow Cytometry//Western Blot Our results showed that CTD-2562J17.6 and FENDRR were significantly downregulated while MIR205HG, LNC_000378, RP11-116G8.5, RP3-523K23.2, and RP5-968D22.1 were significantly upregulated in all five LUSC samples. Importantly, MIR205HG was upregulated in LUSC clinical samples as well as in LUSC cell lines. No 32188965 MINCR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression(highly expressed) qRT-PCR The significant overexpression of MINCR and EZH2 were observed in the CRC tissues compared to control tissues (p < 0.0001). No 34923811 MINCR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR Our results showed that MINCR was significantly upregulated in HCC tissues, compared with paired adjacent nontumor tissue samples. MINCR upregulation was correlated with TNM stage (p = 0.005) and histological grade (p = 0.001). The results of Kaplan-Meier method and log-rank test indicated that the 5-years overall survival of the high MINCR group was significantly lower than that of low MINCR group (p = 0.0035). Univariate and multivariate analysis results indicated that MINCR was an independent prognostic factor in HCC (p < 0.05). No 30556858 MINCR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[CDK2 ] qRT-PCR The expression of LncRNA-MINCR and CDK2 mRNA in primary hepatocellular carcinoma tissues was higher than that in the adjacent tissues [(5.51±0.62) vs (1.62±0.51), (4.52±0.73) vs (1.85±0.95), P<0.05]. The two play a synergistic role in the invasion, invasion and metastasis of hepatocarcinoma cells. LncRNA-MINCR expression was associated with TNM staging, lymph node metastasis, and cirrhosis (P<0.05). CDK2 mRNA expression was associated with tumor diameter, TNM stage, lymph node metastasis, and serum alpha-fetoprotein levels (P<0.05). The 3-year survival rate of patients with high expression of LncRNAMINCR was lower than that of LncRNA-MINCR low expression group [53.49% vs 77.38%, 2=13.024, P<0.05). No 30947664 MILIP LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(STC2) CCK8//qRT-PCR//Invasion Assay//Migration Assay The results indicated that expression of LncRNA MAFG-AS1 in the breast cancer tissues was significantly higher than the adjacent normal breast tissues and elevated expression level of LncRNA MAFG-AS1 was correlated to the larger tumor size, negative expression of ER, PR and lymph node metastasis. Mechanically, LncRNA MAFG-AS1 was mainly located in the cytoplasm. The downstream target gene of LncRNA MAFG-AS1 was STC2 which might promote cell proliferation and metastasis in breast cancer and this study provides a new potential therapeutic target for breast cancer. The results indicated that expression of LncRNA MAFG-AS1 in the breast cancer tissues was significantly higher than the adjacent normal breast tissues and elevated expression level of LncRNA MAFG-AS1 was correlated to the larger tumor size, negative expression of ER, PR and lymph node metastasis. No 35513366 MILIP LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR MAFG-AS1 was distinctly up-regulated in CRC specimens compared to matched non-tumor specimens (p < 0.01). High MAFG-AS1 expressions were closely associated with depth of invasion (p = 0.011) and TNM stage (p = 0.022). Survival assays revealed that patients with high expression of MAFG-AS1 have a shorter overall survival (p = 0.0030) and disease-free survival (p = 0.0002). No 33295405 MILIP LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction[downregulation of miR-6852] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Based on The Cancer Genome Atlas database and reverse transcription-quantitative PCR results, it was determined that lncRNA MAFG-AS1 expression was increased in HCC tissues and cell lines. Inhibition of miR-6852 increased proliferation, migration and invasion of HCC cell lines. LncRNA MAFG-AS1 promoted HCC development by dampening miR-6852 function and may thus be a novel target for treating patients with HCC. No 31572506 LOC101926889 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 834 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC101241902 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NONHSAT159665.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 LINC00930 LncRNA Homo sapiens Endometrial Neoplasms Serum and tissue samples Expression(highly expressed) RNA-seq At the same time, lncRNA sequencing results showed that when endometrial atypical hyperplasia continued to change, including LINC00511, PVT1, and IQCH-AS1 (downregulated), and only changed significantly in the endometrial dysplasia group, including MALAT1, CARMN (downregulated) and LINC00648, BISPR, LINC01534, and LINC00930 (upregulated). No 36510632 LINC00926 LncRNA Homo sapiens Breast Neoplasms breast cancer cells Interaction(FOXO3A/LINC00926/PGK1 axis) RNA Pull-Down//qRT-PCR//FISH//Luciferase Report Assay//IHC//Invasion Assay we identify a lncRNA LINC00926 that negatively regulates PGK1 expression and predicts good clinical outcome of breast cancer. LINC00926 downregulates PGK1 expression through the enhancement of PGK1 ubiquitination mediated by E3 ligase STUB1. Moreover, hypoxia inhibits LINC00926 expression and activates PGK1 expression largely through FOXO3A. FOXO3A/LINC00926/PGK1 axis regulates breast cancer glycolysis, tumor growth, and lung metastasis both in vitro and in vivo. In breast cancer patients, LINC00926 expression is negatively correlated with PGK1 and positively correlated with FOXO3A expression. we identify a lncRNA LINC00926 that negatively regulates PGK1 expression and predicts good clinical outcome of breast cancer. No 33940159 LINC00926 LncRNA Homo sapiens Stress Disorders, Post-Traumatic PTSD sample Interaction(MLL1/IFNG and IL17A) ELISA//RNA-seq Increased H3K4me3 resulted from LINC00926, which we found to be upregulated in the PTSD sample, bringing in histone methyltransferase, MLL1, onto WNT10B promotor leading to the introduction of H3K4 trimethylation. The addition of recombinant human WNT10B to pre-activated peripheral blood mononuclear cells (PBMCs) led to increased expression of inflammatory genes such as IFNG and IL17A, suggesting that WNT10B is involved in their upregulation. Together, our data suggested that LINC00926 interacts physically with MLL1 and thereby controls the expression of IFNG and IL17A. This is the first time a long non-coding RNA is shown to regulate the expression of WNT10B and consequently inflammation. This observation has high relevance to our understanding of disease mechanisms of PTSD and comorbidities associated with PTSD. No 35551428 LINC00924 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00923 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 LINC00917 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Serum-derived exosomal Expression(highly expressed) qRT-PCR Serum-derived exosomal LINC00917 was highly expressed in NSCLC patients, and further upregulated in stage III/IV cancer patients. Serum-derived exosomal LINC00917 was highly expressed in NSCLC patients, and further upregulated in stage III/IV cancer patients. Exosomal LINC00917 yielded modestly good under the curve (AUC) values. Upregulated exosomal LINC00917 expression was closely associated with cancer patients' advanced stages and shorter OSs. No 35003204 LINC00900 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression(lower expressed) Bioinformatics Analysis Expression of SLC16A-AS1 was significantly lower in breast cancer tissues compared with paired non-cancerous samples (expression ratio = 0.27, P value < 0.001). Similarly, LINC00900 was down-regulated in cancer tissues compared with non-cancerous ones (expression ratio = 0.26, P value = 0.01). No 36641651 LINC00896 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Regulation Bioinformatics Analysis Combined with the overall survival data, we established 6 six lncRNA-based signature to predict prognosis, which were LINC00896, AC007996.1, NKILA, AP003555.2, MIRLET7BHG, and AC009237.14. We found that the expression level of PD-L1 (CD274) and somatic mutations in the high-risk group were higher than those in the low-risk group. No 34790382 LINC00892-201 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[lower expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 12. No 31619123 LINC00888 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00884-202 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC00881 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LINC00877-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC00862 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LINC00861 LncRNA Homo sapiens COVID-19 126 blood samples Expression(highly expressed) Bioinformatics Analysis Upon further investigation on an individually selected lncRNA level, some lncRNA genes were significantly enriched in the COVID-19/ICU, while some were enriched in the COVID-19/non-ICU group (Figures 5c and 5d). Selected lncRNAs are presented as violin plots depicting upregulation of LINC02207, AC020636.1, AC243967.2, LINC01127, AC00727.1 and AC092746.1 in the COVID-19/ICU group, whereas those enriched in the COVID-19/non-ICU group include LINC02084, LINC02446, LINC00861, AC015911.3, LINC01871 and ANKRD44-AS1 with ANOVA p values of <0.0001. No 33898797 LOC101060038 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 811 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC00858 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR We observed that LINC00858 was distinctly up-regulated in GC tissues compared to adjacent non-tumor specimens (p < 0.01). Higher expression of LINC00858 in GC was found to be associated with TNM stage (p = 0.003) and lymphatic metastasis (p = 0.007). Using Kaplan-Meier assays, we found that patients with high expression levels of LINC00858 had a distinctly poor overall survival and disease-free survival compared to those with low expression levels of LINC00858 (p = 0.0102). No 32119160 LINC00839 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00839 LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma cells（MHCC97H） Interaction( miR-3666) qRT-PCR Compared with adjacent tissues, the expression level of LINC00839 in hepatocellular carcinoma tissues increased (2.82±0.27 vs. 0.96±0.10, P<0.001), but the expression level of miR-3666 decreased (0.23±0.02 vs. 1.01±0.10, P<0.001). The expression levels of LINC00839 and miR-3666 in liver cancer tissue were negatively correlated (r=-0.658, P<0.001). The survival rate of MHCC97H cells in the si-LINC00839 group [(53.91±5.41)% vs. (100.53±10.22)%], the number of clones formed (92.0±8.0 vs. 164.0±14.3), the number of migration (131.0±12.7 vs. 247.0±22.4), the number of invasion (66.0±6.4 vs. 120.0±11.6) and the protein level of MMP-2 (0.20±0.02 vs. 0.67±0.06) were lower than those in the si-NC group (P<0.001). However, the protein levels of p21 (0.76±0.07 vs. 0.25±0.02) and E-cadherin (0.78±0.08 vs. 0.14±0.01) were higher than those in the si-NC group (P<0.001). LINC00839 targeted and negatively regulated the expression of miR-3666. The survival rate of MHCC97-H cells in the miR-3666 group [(47.93±4.86)% vs. (100.11±10.21)%], the number of clone formation (78.0±7.7 vs. 166.0±15.9), the number of migration (117.0±12.1 vs. 250.0±25.0), the number of invasion (57.0±5.7 vs. 121.0±12.3) and the protein level of MMP-2 (0.16±0.01 vs. 0.69±0.07) were lower than those in the miR-NC group (all P<0.001). However, the protein levels of p21 (0.83±0.08 vs. 0.24±0.02) and E-cadherin (0.87±0.09 vs. 0.13±0.01)were higher than those in the miR-NC group (all P<0.001). The survival rate of MHCC97-H cells in the si-LINC00839+ anti-miR-3666 group [(89.94±9.05)% vs. (54.12±5.39)%], the number of clones (143.0±13.8 vs. 94.0±9.4), the number of migration (208.0±19.8 vs. 129.0±12.6), the number of invasion (108.0±10.1 vs. 65.0±6.4) and the protein level of MMP-2 (0.31±0.03 vs 0.66±0.06) were higher than those in the si-LINC00839+ anti-miR-NC group (P<0.001). However, the protein levels of p21 (0.31±0.03 vs. 0.74±0.07) and E-cadherin (0.28±0.03 vs. 0.80±0.08) were lower than those int the si-LINC00839+ anti-miR-NC group (P<0.001). No 34794216 LINC00702 LncRNA Homo sapiens Meningioma malignant meningioma tissues and cell lines Regulation[LINC00702/miR-4652-3p/ZEB1 axis,Wnt/β-catenin pathway] qRT-PCR Bioinformatics analysis and mechanism experiments demonstrated that LINC00702 acted as the molecular sponge of miR-4652-3p to upregulate ZEB1 in malignant meningioma. Furthermore, high level of LINC00702 was demonstrated to be associated with the activity of Wnt/β-catenin signaling. Moreover, miR-4652-3p and ZEB1 involved in LINC00702-mediated Wnt/β-catenin signaling. At last, rescue assays revealed that miR-4652-3p and ZEB1 attenuated LINC00702-mediated cell proliferation and migration. No 30849635 LINC00700 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00674 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00673 LncRNA Homo sapiens Stomach Neoplasms gastric tissues Mutation[rs11655237 ] qRT-PCR//Genotyping Our results indicate that LINC00673 rs11655237 is associated with an increased GC risk, possibly by down-regulating LINC00673 expression through creating a miR-1231 binding site. No 31118802 LINC00673 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00673 LncRNA Homo sapiens Carcinoma, Hepatocellular 783 HCC patients and 1197 healthy subjects Mutation(rs9914618, rs6501551, rs11655237 ) qRT-PCR A TaqMan allelic discrimination assay was performed to analyze the genotypes of three tagging SNPs, viz., rs9914618 G > A, rs6501551 A > G, and rs11655237 C > T, of LINC00673 in 783 HCC patients and 1197 healthy subjects. Associations of functional SNPs of LINC00673 with HCC susceptibility and clinicopathologic variables were analyzed by logistic regression models. After stratification by confounding factor, we observed that elderly patients (≥60 years) with the LINC00673 rs9914618 A allele had an increased risk of developing HCC under a codominant model (p = 0.025) and dominant model (p = 0.047). Moreover, elderly patients carrying the GA + AA genotype of rs9914618 exhibited a higher risk of having lymph node metastasis compared to those who were homozygous for the major allele (p = 0.013). Genotype screening of rs9914618 in HCC cell lines showed that cells carrying the AA genotype expressed higher LINC00673 levels compared to the cells carrying the GG genotype. No 36361527 LINC00673 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR//Microarray The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated). No 32020063 LINC00673 LncRNA Homo sapiens Neuroblastoma blood Mutation[rs11655237 C>T] Genotyping After pooling all enrolled patients, we observed a significant association between LINC00673 rs11655237 C>T and risk of neuroblastoma (TT vs. CC: adjusted odds ratio [OR]=1.58, 95% confidence interval [CI]=1.06-2.35, P=0.024; additive model: adjusted OR=1.20, 95% CI=1.03-1.39, P=0.020; recessive model: adjusted OR=1.50, 95% CI=1.02-2.22, P=0.040). No 31005956 LINC00673 LncRNA Homo sapiens Wilms Tumor blood Mutation[rs11655237 C>T] Genotyping In conclusion, we failed to find any association between the LINC00673 rs11655237 C>T polymorphism and WT risk. This finding needs to be verified in larger studies and other populations. No 31257678 LINC00665-201 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck plasma of 28 cases with TNM I/II [early-stage squamous cell carcinoma (ESCC) group], 36 cases with TNM III/IV [advanced-stage squamous cell carcinoma (ASCC) group], 16 cases with dysplasia [oral premalignant lesion (OPL) group] and 16 healthy controls (H group) Regulation qRT-PCR//Microarray The expression level of ENST00000412740, NR_131012, ENST00000588803 and NR_038323 exhibited significant differences in the H, OPL, ESCC and ASCC groups (P<0.05). ROC curve and logistic regression analyses revealed that the diagnostic efficacy of the combined lncRNAs was more prominent than that of a single lncRNA, particularly in the ESCC and ASCC groups. No 33552289 LINC00665 LncRNA Homo sapiens Glioma glioma tissues and cells regulation[STAU1-Mediated mRNA Degradation] qRT-PCR In this study, we demonstrated that TATA-box binding protein associated factor 15 (TAF15) and long intergenic non-protein coding RNA 665 (LINC00665) were both downregulated in glioma tissues and cells. Our study highlights a key role of the TAF15/LINC00665/MTF1(YY2)/GTSE1 axis in modulating the malignant biological behaviors of glioma cells, suggesting novel mechanisms by which lncRNAs affect STAU1-mediated mRNA stability, which can inform new molecular therapies for glioma. No 32464546 LINC00938 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00941 LncRNA Homo sapiens Pulmonary Fibrosis fibroblast Regulation In Vivo Experiment//Wound Healing Assay//Migration Assay//FISH//RIP Here, highly upregulated LINC00941/lncIAPF was found to accelerate pulmonary fibrosis by promoting fibroblast-to-myofibroblast differentiation and myofibroblast proliferation and migration. No 35427207 LINC00944 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC cells Interaction(DMDRMR/miR-378a-5p/DAB2IP axis) In Vivo Experiment//ELISA//Tube Formation Assay Here, we demonstrated that the lncRNA DMDRMR serves as a sponge of miR-378a-5p to increase EZH2 and SMURF1 expression, thus promoting EZH2-mediated transcriptional repression of DAB2IP and SMURF1-mediated degradation of DAB2IP. Consequently, this axis activates VEGFA/VEGFR2 signaling pathway, resulting in angiogenesis and resistance of tumor cells to sunitinib in ccRCC. Our results support that the DMDRMR/miR-378a-5p/DAB2IP axis may serve as a novel target for combination diagnosis or therapy of ccRCC patients. Moreover, the competing endogenous RNA regulatory axis of DMDRMR is clinically relevant to ccRCC pathogenesis and prognosis of patients with ccRCC. No 35562342 LINC00944 LncRNA Homo sapiens Breast Neoplasms breast cancer cells Regulation qRT-PCR//Western Blot Here, we show that LINC00944 is responsive to ADAR1 up- and downregulation in breast cancer cells.Moreover, we found that LINC00944 expression was correlated to the age at diagnosis, tumor size, and estrogen and progesterone receptor expression. Moreover, we found that LINC00944 expression was correlated to the age at diagnosis, tumor size, and estrogen and progesterone receptor expression.Finally, we show that low expression of LINC00944 is correlated to poor prognosis in breast cancer patients. No 33383047 LINC01060 LncRNA Homo sapiens Glioma glioma tissues regulation[MZF1/c-Myc/HIF1α Axis] qRT-PCR Clinically, Linc01060 was upregulated in glioma and was significantly correlated with tumor grade and poor clinical prognosis. Clinically, Linc01060 was upregulated in glioma and was significantly correlated with tumor grade and poor clinical prognosis. These findings suggest that inhibition of Linc01060-containing exosomes or targeting the Linc01060/MZF1/c-Myc/HIF1α axis may be an effective therapeutic strategy in glioma. No 33158815 LINC01055 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[highly expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 LINC01038 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 602 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC01032 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1069 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC01019 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01006-211 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01006 LncRNA Mus musculus Carcinoma, Hepatocellular HCC cells and tissues Regulation(miR-194-5p/CADM1 axis) qRT-PCR LINC01006 and CADM1 displayed upregulation, but miR-194-5p exhibited downregulation in HCC cells and tissues. Short hairpin (sh)-LINC01006 and miR-194-5p mimics repressed the proliferative, migratory, and invasive capacities of HCC cells, and injection of sh-LINC01006 restrained the growth of HCC tumours in mice. LINC01006 served as a competing endogenous RNA of miR-194-5p and was inversely correlated with miR-194-5p. CADM1 was targeted by miR-194-5p, inversely correlated with miR-194-5p, and positively associated with LINC01006. Furthermore, transfection of pcDNA-CADM1 or the miR-194-5p inhibitor reversed the suppressive effects of sh-LINC01006 on the proliferation, invasion, and migration abilities of HCC cells. No 34718169 LINC01004 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 565 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC01001 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[lower expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 LINC00997 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00989-202 LncRNA Homo sapiens Diabetes Mellitus, Type 2 five patients with T2D and paired controls Expression(highly expressed) qRT-PCR//Bioinformatics Analysis//Microarray The top five upregulated lncRNAs are ENST00000381108.3, ENST00000515544.1, ENST00000539543.1, ENST00000508174.1, and ENST00000564527.1, and the top five downregulated lncRNAs are TCONS_00017539, ENST00000430816.1, ENST00000533203.1, ENST00000609522.1, and ENST00000417079.1. No 35257412 LINC00989-201 LncRNA Homo sapiens Diabetes Mellitus, Type 2 five patients with T2D and paired controls Expression(highly expressed) qRT-PCR//Bioinformatics Analysis//Microarray The top five upregulated lncRNAs are ENST00000381108.3, ENST00000515544.1, ENST00000539543.1, ENST00000508174.1, and ENST00000564527.1, and the top five downregulated lncRNAs are TCONS_00017539, ENST00000430816.1, ENST00000533203.1, ENST00000609522.1, and ENST00000417079.1. No 35257412 LINC00987 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00968-209 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC00968-007 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC and matched adjacent non-tumor lung tissues Expression[lower expressed] qRT-PCR//Microarray FENDRR-005 and LINC00968-007 were downregulated in NSCLC compared with matched adjacent normal tissues, and DLEU1 and LINC01617 were upregulated in NSCLC compared with matched adjacent normal tissues. No 31348244 LINC00968 LncRNA Homo sapiens Coronary Artery Disease Epicardial adipose tissue of 19 CAD patients and 24 non-CAD patients Regulation qRT-PCR We confirmed a dysregulated intergenic lncRNA (lincRNA) (LINC00968) by real-time quantitative PCR (RT-qPCR).  No 33452392 LINC00968 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[lower expressed] qRT-PCR//Microarray The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated). No 32020063 LINC00968 LncRNA Homo sapiens Arthritis, Rheumatoid peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR//RNA-seq In the present study, 231 upregulated and 110 downregulated lncRNAs were identified as differentially expressed in patients with RA compared with the controls. Information on the top 6 up- or downregulated lncRNAs is provided in Table III. No 33456537 LINC00964 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1059 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC00963-236 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC00963-223 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC00963-213 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 LINC00963 LncRNA Homo sapiens Breast Neoplasms 71 luminal A and B tumor tissues and two luminal A cell lines Expression(highly expressed) qRT-PCR//Bioinformatics Analysis The results showed the significant upregulation of all three lncRNAs in luminal A and B tumor specimens and cell lines. Upregulation of DUXAP8 and FOXD2-AS1 was significantly associated with progesterone receptor-positive (PR+) and p53 protein expression in luminal BC patients, respectively. No 34043149 LINC00963 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LINC00961/SPAAR LncRNA Rattus norvegicus Myocardial Infarction murine endothelial cell line Mutation(Locus Loss) RNA-seq Data mining suggested that SPAAR is predominantly expressed in human cardiac endothelial cells and fibroblasts, while murine LINC00961 expression is hypoxia-responsive in mouse endothelial cells. LINC00961 mice displayed a sex-specific delay in longitudinal growth and development, smaller left ventricular systolic and diastolic areas and volumes, and greater risk area following myocardial infarction compared with wildtype littermates. These data suggest the LINC00961/SPAAR locus contributes to cardiac endothelial cell and fibroblast function and hypoxic response, growth and development, and basal cardiovascular function in adulthood. No 33478078 LINC00958 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR LINC00958 was shown to be dramatically elevated in GC relative to normal controls. Elevated LINC00958 significantly correlated with lymph nodes metastases, distance metastasis, peritoneal dissemination, and peritumoral tissues infiltration (p<0.05). The Kaplan-Meier survival analysis showed that up-regulated LINC00958 was markedly associated with inferior overall survival (p<0.001). No 30720167 LINC00958 LncRNA Homo sapiens Pancreatic Neoplasms cell lines Regulation[PAX8LINC00958/miR-330-5p/PAX8axis ] FISH//RNA Pull-Down//Luciferase Report Assay//qRT-PCR LINC00958 and PAX8 were up-regulated, while miR-330-5p was down-regulated during PC.Therefore, silencing of LINC00958 may bind to miR-330-5p to inhibit PAX8 in a competitive fashion, thereby preventing the progression of PC. No 30639194 LINC00957 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00957 LncRNA Homo sapiens Colorectal Neoplasms Colorectal Cancer tissues,cell lines Expression[Expression[highly expressed]-expression] qRT-PCR//Western Blot Our research revealed that LINC00957 was significantly higher expression in CRC.Mechanically, inhibition of LINC00957 expression reversed 5-FU resistance by Expression[down-expression]-regulating P-gP. In addition, the LINC00957 expression was associated with TNM stage and chemotherapy outcome, but age, gender, tumor size, histological grade, primary tumor location. CRC patients with high LINC00957 expression level showed poor overall survival (P = 0.002). Multivariate survival analysis indicated that LINC00957 was a prognostic factor for CRC patients (P = 0.010). No 31497531 LINC00665 LncRNA Homo sapiens Adenocarcinoma of Lung lung cancer tissues Regulation(LINC00665-miR-let-7b-CCNA2) qRT-PCR Through stepwise reverse prediction and validation from miRNA to lncRNA, four key lncRNAs were identified using expression and survival analysis. Ultimately, the co-expression analysis identified LINC00665-miR-let-7b-CCNA2 as the key ceRNA network associated with the prognosis of LUAD. We successfully constructed a novel ceRNA network wherein each component was significantly associated with the prognosis of LUAD. LINC00665-miR-let-7b-CCNA2 competing endogenous RNA network associated with prognosis of lung adenocarcinoma No 33627711 LINC00665 LncRNA Homo sapiens Carcinoma, Hepatocellular Regulation Survival Analysis Classification analysis developed a three-lncRNA signature of AC005332.5, ELF3-AS1 and LINC00665, which was demonstrated to be the most discriminatory with an AUC (Area under the curve) value of 0.913 (95% CI: 0.8610-0.9665) and verified in validation patients. The expression levels of AC005332.5, ELF3-AS1 and LINC00665 were significantly changed with different tumor stages or grades. Survival analysis revealed that AC005332.5, ELF3-AS1 and LINC00665 were highly associated with the prognosis of overall survival. Additionally, the lncRNA signature yielded statistical significance to predict clinical outcomes independently from other clinical variables in validation patients, as suggested in the multivariate Cox hazards analysis. Conclusively, a three-lncRNA signature of AC005332.5, ELF3-AS1 and LINC00665 may serve as an excellent diagnostic biomarker for HBV-related HCC and potential prognostic significance for HBV-related HCC sufferers. Classification analysis developed a three-lncRNA signature of AC005332.5, ELF3-AS1 and LINC00665, which was demonstrated to be the most discriminatory with an AUC (Area under the curve) value of 0.913 (95% CI: 0.8610-0.9665) and verified in validation patients.The expression levels of AC005332.5, ELF3-AS1 and LINC00665 were significantly changed with different tumor stages or grades.Survival analysis revealed that AC005332.5, ELF3-AS1 and LINC00665 were highly associated with the prognosis of overall survival. Additionally, the lncRNA signature yielded statistical significance to predict clinical outcomes independently from other clinical variables in validation patients, as suggested in the multivariate Cox hazards analysis No 35802466 LINC00662 LncRNA Homo sapiens Gallbladder Neoplasms GBC tissues and cells Expression(highly expressed) RNA-seq//Genotyping AC084082.3 and LINC00662 showed increasing expression levels (p-value = 0.009), while C22orf34 expression decreased in the sequence from gallstones to GBC (p-value = 0.04). No 35158906 LINC00525 LncRNA Homo sapiens Urinary Bladder Neoplasms cell lines Expression[highly expressed] qRT-PCR As shown in Figure 8A and ​andB,B, the expression of 4 lncRNAs (MIR137HG, LINC00525, ERVH48-1 and LINC00518) was upregulated, while the expression of AC110491.1 and ADAMTS9-AS1 was downregulated in MIBC tissues and bladder cancer cells (T24, J82, UM-UC-3, TCCSUP and SW780) compared with the expression in adjacent nontumor bladder tissues and the immortalized SV-HUC-1 uroepithelial cells, respectively. No 31308745 LINC00518 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Regulation[inhibition of CDX2 methylation and the Wnt signaling pathway] Western Blot//Wound Healing Assay//Tunel//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Transwell Assay//EdU Staining//ChIP The results of RT-qPCR showed that there was a significantly higher LINC00518 expression in BC tissues than that in adjacent normal tissue (p < 0.05) (Fig. 1C). No 30611858 LINC00518 LncRNA Homo sapiens Colorectal Neoplasms colorectal tumors Expression [highly expressed] Bioinformatics Analysis Our results nominated ESRG, LINC00518, PWRN1, and TTTY14 lncRNAs as the top-hit novel lncRNAs with aberrant expression in colon cancer. The qPCR method was used to profile these lncRNAs that showed the up-regulation of ESRG and LINC00518, and down-regulation of TTTY14 in thirty paired colorectal cancer specimens. No 34896077 LINC00518 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues,cell lines Expression[highly expressed] qRT-PCR//MTT//Luciferase Report Assay//Western Blot Linc00518 was highly expressed in prostate tumour both in vivo and in vitro. No 30462844 LINC00518 LncRNA Homo sapiens Urinary Bladder Neoplasms cell lines Expression[highly expressed] qRT-PCR As shown in Figure 8A and ​andB,B, the expression of 4 lncRNAs (MIR137HG, LINC00525, ERVH48-1 and LINC00518) was upregulated, while the expression of AC110491.1 and ADAMTS9-AS1 was downregulated in MIBC tissues and bladder cancer cells (T24, J82, UM-UC-3, TCCSUP and SW780) compared with the expression in adjacent nontumor bladder tissues and the immortalized SV-HUC-1 uroepithelial cells, respectively. No 31308745 LINC00511-268 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC00511-252 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC00511-226 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC00511-205 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[highly expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 LINC00511 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cells Expression[highly expressed] qRT-PCR LINC00511 and CDK6 were upregulated while miR-29c was downregulated in breast cancer tissues and cells. No 31047896 LINC00511 LncRNA Homo sapiens Breast Neoplasms BC patients' blood Interaction( miR-185-3p) qRT-PCR LINC00511 and miR-301a-3p, in BC patients' blood, were overexpressed, and their median levels increased significantly, while miR-185-3p was, in contrast, downregulated, being decreased fourfold. LINC00511 was elevated in BC early stages, when compared to late stages (p < 0.0003). LINC00511, miR-185-3p, and miR-301a-3p showed AUC superior to classical TMs, allowing us to conclude that the investigated ncRNAs, in BC patients' liquid biopsy, are novel diagnostic molecular biomarker signatures.Additionally, both LINC00511 and miR-301a-3p were positively correlated with the aggressiveness of BC, as manifested in patients with larger tumors (>2 cm) at (p < 0.001). No 34745973 LINC00511 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[LINC00511/EZH2/IL-24 axis] qRT-PCR//RIP//Western Blot LINC00511 was an upregulated lncRNA in CRC tissues and cells, which played an oncogenic role by strengthening the malignant phenotypes of CRC cells.Those data together demonstrated the contribution of HNF4α to the progression of CRC through mediating the LINC00511/EZH2/IL-24 axis. No 33052062 LINC00511 LncRNA Homo sapiens Endometrial Neoplasms Serum and tissue samples Expression(lower expressed) RNA-seq At the same time, lncRNA sequencing results showed that when endometrial atypical hyperplasia continued to change, including LINC00511, PVT1, and IQCH-AS1 (downregulated), and only changed significantly in the endometrial dysplasia group, including MALAT1, CARMN (downregulated) and LINC00648, BISPR, LINC01534, and LINC00930 (upregulated). No 36510632 LINC00511 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[differently-expression] qRT-PCR//Microarray "The identified 199 lncRNAs were then analysed, retaining only those transcripts for which experimentally validated microRNA (miRNA) targets had already been annotated in starBase and, among these, only lncRNAs that targeted at least 10 miRNAs were selected. Using this approach, we obtained 6 lncRNAs, including CTD-2020K17.1, LINC00657, RP11-169K16.9, LINC00511, RP11-372K14.2 and RP11-214O1.2. (Table 2)" No 31480511 LINC00511 LncRNA Homo sapiens COVID-19 peripheral blood Regulation qRT-PCR Expression of SNHG6 was considerably lower in COVID-19 patients compared with control subjects (Ratio of mean expression (RME) = 0.22, P value = 7.04E-05) and in both female and male COVID-19 patients compared with sex-matched unaffected individuals (RME = 0.32, P value = 0.04 and RME = 0.16, P value = 0.000679683, respectively). However, its expression was similar among ICU-hospitalized and non-ICU patients. Similarly, expression of SNHG16 was lower in in COVID-19 patients compared with controls (RME = 0.20, P value = 5.94E-05) and in both female and male patients compared with sex-matched controls (RME = 0.32, P value = 0.04 and RME = 0.14, P value = 0.000496435, respectively) with no significant difference among ICU-hospitalized and non-ICU hospitalized patients. Expression of VDR was lower in COVID-19 patients compared with controls (RME = 0.42, P value = 0.04) and in male patients compared with male controls (RME = 0.27, P value = 0.02). Yet, expression of VDR was statistically similar between female subgroups and between ICU-hospitalized and non-ICU hospitalized patients. Expression levels CYP27B, Linc00511 and Linc00346 were similar among COVID-19 patients and healthy subjects or between their subgroups. Significant correlations have been detected between expression levels of VDR, CYP27B and SNHG6, SNHG16, Linc00511 and Linc00346 lncRNAs both among COVID-19 patients and among healthy controls with the most significant ones being SNHG6 and SNHG16 (r = 0.74, P value = 3.26e-17 and r = 0.81, P = 1.54e-22, respectively). No 34147082 LINC00488 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[miR-330-5] RNA Pull-Down//Luciferase Report Assay//RIP//Microarray The fundamental findings of the present study collectively propose that lncRNA LINC00488 can competitively sponge miR-330-5p to regulate TLN1 in relation to the cell growth and angiogenesis in HCC. No 31005556 LINC00488 LncRNA Homo sapiens Thyroid Neoplasms thyroid cancer cell lines (BCPAP, BHP5-16, TPC-1 and CGTH-W3) Interaction(miR-376a-3p/PON2) Western Blot//Wound Healing Assay//Immunoblotting//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay Our findings revealed that LINC00488 was highly expressed in thyroid cancer cell lines (BCPAP, BHP5-16, TPC-1 and CGTH-W3) and promoted the proliferation, migration and invasion, while inhibited the apoptosis of thyroid cancer cells (BCPAP and TPC-1). The results of bioinformatics analysis and dual luciferase reporter gene assay showed that LINC00488 could directly bind to miR-376a-3p and down-regulated the expression level of miR-376a-3p. In addition, Paraoxonase-2 (PON2) was a target gene of miR-376a-3p and negatively regulated by miR-376a-3p. No 33600548 LINC00477 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] CCK8//qRT-PCR//RNA Pull-Down//RIP The overall expression of LINC00477 was reduced in gastric cancers compared to normal gastric tissues. No 31191018 LINC00475 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)56) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 LINC00473 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Expression[highly expressed] CCK8//qRT-PCR//Colony Formation Assay The findings of the present study demonstrated that in ESCC tissues and cells, the expression levels of LINC00473 and CDC25A were significantly upregulated, while the expression of miR?497?5p was downregulated. No 32468021 LINC00473 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Expression[highly expressed] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay LINC00473 and FOXP1 were up-regulated, while miR-345-5p was down-regulated in HCC tissues and cells. No 32021265 LINC00473 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues and cell lines Expression[highly expressed] qRT-PCR//MTT//Colony Formation Assay//Western Blot LncRNA LINC00473 was upregulated in HNSCC tissues and cell lines. No 30468475 LINC00473 LncRNA Homo sapiens Neoplasms tumor tissues Expression(highly expressed) Bioinformatics Analysis The aggregated results revealed that high expression of LINC00473 was significantly associated with unfavorable overall survival (HR = 1.66, 95% CI: 1.48-1.86, P < .00001), disease-free survival (HR = 1.59, 95% CI: 1.09-2.32, P = .02) in a variety of cancers. The aggregated results revealed that high expression of LINC00473 was significantly associated with unfavorable overall survival (HR = 1.66, 95% CI: 1.48-1.86, P < .00001), disease-free survival (HR = 1.59, 95% CI: 1.09-2.32, P = .02) in a variety of cancers. No 36596056 LINC00472 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00472 LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues interaction[binding to YBX1] qRT-PCR//RNA Pull-Down//RIP LINC00472 expression in lung adenocarcinoma tissues was significantly lower and tightly associated with patient prognosis and TNM clinical stages in lung adenocarcinoma.These results indicated that LINC00472 inhibited the cell EMT process by binding to YBX1, and affected the mechanical properties of the cell, ultimately inhibited its ability to invade and metastasize. LINC00472 expression in lung adenocarcinoma tissues was significantly lower and tightly associated with patient prognosis and TNM clinical stages in lung adenocarcinoma. No 33144579 LINC00470 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial 35 cases of EOC patients (malignant group) and 20 cases of benign ovarian tumor patients (benign group) Expression(highly expressed) qRT-PCR Compared with the benign and normal groups, the expression of FER1L6-AS2, LINC00470 and LINC01811 in malignant group increased by 1.66 and 1.84-fold, 2.05 and 2.46-fold, 2.94 and 2.35-fold, respectively; the expressions of CXXC4-AS1, LINC02343 and LINC02428 were down-regulated to 29% and 34%, 40% and 46%, 42% and 42%, respectively. No 35385957 LINC00467 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00467 LncRNA Homo sapiens Leukemia, Myeloid, Acute plasma exosomal Expression(lower expressed) qRT-PCR Subsequently, the downregulated plasma exosomal lncRNAs (LINC00265, LINC00467, and UCA1) and the upregulated plasma exosomal lncRNA (SNHG1) were identified in AML patients (n=65) compared to HD (n=20). No 36276083 LINC00523 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LINC00525 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR The expressions of LINC00525 in CRC were significantly increased when compared with that in the normal intestinal tissues (Fig. 1b, p<0.01). No 31242722 LINC00661 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00526 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00659 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00654 LncRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR The combination of ZFAS1, SNHG11, LINC00909 and LINC00654 showed high diagnostic performance for CRC (AUC: 0.937), especially early-stage disease (AUC: 0.935). Plasma levels of the four candidate lncRNAs were significantly reduced in postoperative samples compared to preoperative samples. No 31633800 LINC00654 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LINC00649 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00649 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow Expression[lower expressed] qRT-PCR LINC00649 was underexpressed in bone marrow of AML group than that in healthy control group. The patients of LINC00649-low group have significantly inferior PFS and OS. No 32883226 LINC00649 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Interaction(miR-216a-3p) In Vivo Experiment//Transfection//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay LINC00649 expression was increased in cervical cancer tissues, especially in squamous histology, positive lymph node metastasis, and high-FIGO stage tissues. LINC00649 could bind directly with miR-216a-3p. Silence of LINC00649 could enhance the expression of miR-216a-3p and suppress the cervical cancer cell proliferation abilities, migration capacities, and invasion power. Whereas, transfection of miR-216a-3p inhibitor partially reverses the above cellular activities changes in cervical cancer cells. The higher expression of LINC00649 predicted a shorter survival rate for patients. No 36054700 LINC00649 LncRNA Homo sapiens Ischemic Stroke blood Expression[highly expressed] qRT-PCR lnc-ITSN1-2 expression was increased in AIS patients compared to controls (P < .001), and receiver operating characteristic curve revealed its predictive value for AIS risk (area under the curve: 0.804, 95% confidence interval, 0.763-0.845). No 31647141 LINC00649 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[highly expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 3 No 32547537 LINC00649 LncRNA Homo sapiens Sepsis 95 sepsis patients and 50 health controls Expression(highly expressed) qRT-PCR Lnc-ITSN1-2 in sepsis patients was higher than it in health controls (Z = -7.328, p < 0.001). Lnc-ITSN1-2 correlated with increased interferon-gamma (p = 0.009), Th17 cells (p = 0.022), and interleukin-17A (p = 0.006), but not Th1 cells (p = 0.169) in sepsis patients. No 35243686 LINC00648 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 569 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC00648 LncRNA Homo sapiens Endometrial Neoplasms Serum and tissue samples Expression(highly expressed) RNA-seq At the same time, lncRNA sequencing results showed that when endometrial atypical hyperplasia continued to change, including LINC00511, PVT1, and IQCH-AS1 (downregulated), and only changed significantly in the endometrial dysplasia group, including MALAT1, CARMN (downregulated) and LINC00648, BISPR, LINC01534, and LINC00930 (upregulated). No 36510632 LINC00645 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00641 LncRNA Homo sapiens Prostatic Neoplasms 43 pairs of prostate tumoral and non-tumor tissue Expression(lower expressed) qRT-PCR Significant upregulation of LINC00641 (2.47 ± 0.5 vs 1.41 ± 0.2) and downregulation of JPX (1.42 ± 0.6 vs 2.83 ± 1.0) were observed in PC tissues compared with the normal tissues (their adjacent non-tumoral tissues). No 34522197 LINC00638 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC Interaction(miR-4732-3p/ULBP1 Axis) qRT-PCR//Co-IP//FISH Next, we constructed a ceRNA network, LINC00638/miR-4732-3p/ULBP1, that may be responsible for NK cell infiltration in HCC with high TMB. The LINC00638/miR-4732-3p/ULBP1 axis may regulate immune escape via PD-L1 in HCC with high TMB. No 34568062 LINC00636-201 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[lower expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 LINC00632 LncRNA Homo sapiens Colorectal Neoplasms CRC plasma and tissue samples Expression(lower expressed) qRT-PCR The expression levels of ARST were lower in CRC plasma samples compared to that in the patient groups and controls (p < 0.01), while other patient groups and controls showed no significant difference. The expression levels of ARST were also lower in CRC tissues compared to that in non-tumor tissues (p < 0.01). Plasma expression levels of ARST effectively distinguished CRC patients from other patients and controls. The expression levels of ARST were closely correlated with patients' survival. Chi-squared test analysis showed that ARST was closely associated with patients' distant metastasis but not tumor size. No 35018118 LINC00630 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Expression[lower expressed] qRT-PCR qPCR results indicated marked upregulation of CDKN2A-AS1, C7orf55, LINC00184, HEIH, and ZEB2 expression, whereas that of SNHG3, LINC00630, LOC100133669, APTR, LINC-PINT, and SEMA5A was downregulated in OC tissues as compared with levels in normal ovary tissues (Fig. ?(Fig.5b5b). No 31098301 LINC00628 LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues,cell lines Interaction[LAMA3] Western Blot//Transwell Assay//Wound Healing Assay//Flow Cytometry//FISH//RIP//qRT-PCR//MTT//Luciferase Report Assay//IHC//ChIP The results from the TCGA database showed that LINC00628 was highly expressed in lung adenocarcinoma patients as compared to normal control subjects (Figure 2B). Furthermore, qRT-PCR verified that LINC00628 was overexpressed in human lung adenocarcinoma tissues (Figure 2C) and also in the lung adenocarcinoma cell lines (A549, H1650, HCC827, H1975, and H1299) (Figure 2D) (p < 0.05). No 31557618 LINC00622 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 758 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC00606 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 LINC00602 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 820 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC00595 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00589-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC00566 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00562 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LINC00538 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 LINC00534 LncRNA Homo sapiens Breast Neoplasms serum of BC patients and healthy subjects Expression [highly expressed] RNA-seq After a comprehensive comparison of the BC patients and healthy subjects, we discovered five up-regulated exo-lncRNAs and six down-regulated exo-lncRNAs of interest.  No 34733934 LINC00528 LncRNA Homo sapiens Breast Neoplasms TCGA Expression [lower expressed] Bioinformatics Analysis The high expression of four core lncRNAs (AC010595.1, AC046168.1, AC069277.1, and AP000904.1) was associated with worse overall survival, while the low expression of LINC00528 and MIR762HG was associated with worse overall survival. The 6-lncRNA model has an especially good predictive power for overall survival (p < 0.0001) and 3-year survival (the area under the curve = 0.980) in HER2-positive breast cancer patients. The high expression of four core lncRNAs (AC010595.1, AC046168.1, AC069277.1, and AP000904.1) was associated with worse overall survival, while the low expression of LINC00528 and MIR762HG was associated with worse overall survival. The 6-lncRNA model has an especially good predictive power for overall survival (p < 0.0001) and 3-year survival (the area under the curve = 0.980) in HER2-positive breast cancer patients. No 34257572 LINC01060-202 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01063 LncRNA Homo sapiens Breast Neoplasms breast cancer samples Expression [lower expressed] Bioinformatics Analysis Expression levels of lnc-MICAL3-2, lnc-DDX31, LINC01063, LINC02381, ENST0000615051 and lnc-TRIM43B-1 were significantly decreased in breast cancer samples compared with paired control tissues (Posterior mean difference= -2.774, -2.012, -2.012, -2.015, -0.884 and -2.872; P values= 0.019, 0.0001, 0.0001, 0.0001, 0.032 and 0.0001, respectively). No 34175685 LINC01082 LncRNA Homo sapiens Colonic Neoplasms COAD tissues Expression[lower expressed] qRT-PCR "To manifest the expression of integrated analysis, we selected the previously obtained eight biomarkers including XXbac‐ B476C20.9, PP7080, CDKN2B‐AS1, LINC00092, CA3‐AS1, HAND2‐AS1, CTD‐2269F5.1, and LINC01082. In Figure 8, these eight selected DElncRNAs for qRT‐PCR confirmation were eight optimal diagnostic lncRNA biomarkers, and these eight DElncRNAs were all downregulated in the high‐ throughput transcriptome datasets for COAD compared with normal controls. The expression of these selected eight genes in qRT‐PCR was consistent with our integrated analysis." No 30269368 LINC01697-202 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01671-201 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[lower expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 LINC01671 LncRNA Homo sapiens Stomach Neoplasms GC tissues Regulation qRT-PCR Following RT‑qPCR validation, AC016735.2, AP001626.1, RP11‑400N13.3 and RP11‑243M5.2 were considered to be consistent with the prediction of the bioinformatics analysis. Transcriptome sequencing and RT‑qPCR experiments identified 4 lncRNAs, including AC016735.2, AP001626.1, RP11‑400N13.3 and RP11‑243M5.2 to have an important role in the carcinogenesis of GC. No 29693709 LINC01644 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 LINC01630 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01626 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01619-210 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01619-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01618-202 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01614-201 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[highly expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 LINC01614 LncRNA Homo sapiens Stomach Neoplasms gastric cancer cells Expression(highly expressed) CCK8//qRT-PCR//Wound Healing Assay The survival analysis showed that high expression of CCDC144NL antisense RNA 1 (CCDC144NL-AS1) and LINC01614 was positively correlated with the poor prognosis of patients with gastric cancer. The in vitro validation results showed that CCDC144NL-AS1 and LINC01614 were both up-regulated in the gastric cancer cells. The survival analysis showed that high expression of CCDC144NL antisense RNA 1 (CCDC144NL-AS1) and LINC01614 was positively correlated with the poor prognosis of patients with gastric cancer. No 35083139 LINC01614 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC and matched adjacent non-tumor lung tissues Expression[highly expressed] qRT-PCR//Microarray FENDRR-005 and LINC00968-007 were downregulated in NSCLC compared with matched adjacent normal tissues, and DLEU1 and LINC01614 were upregulated in NSCLC compared with matched adjacent normal tissues. No 31348244 LINC01614 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01614 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC microenvironment Expression(highly expressed) qRT-PCR//RNA-seq We reported that LINC00511 and STAT3 expressions in GC tissues and cell lines were observably up-regulated, while miR-625-5p expression was inhibited. miR-625-5p was proved to be a downstream target of LINC00511, and LINC00511 could induce the expression of STAT3 by inhibiting the expression of miR-625-5p. Activation of the stromal and immune cell infiltration was also observed in the high LINC01614 group in the PTC microenvironment. Furthermore, the GILS score and FOXD2-AS1, LINC01614, AC073257.2, and AC005082.1 were also associated with driver mutations and multiple clinical-pathological variables, respectively. No 34604079 LINC01614 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[highly expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 7 No 32547537 LINC01611 LncRNA Homo sapiens Prostatic Neoplasms cell lines Interaction[promote the expressions of GRIN2A and BACE2] CCK8//qRT-PCR//Transwell Assay//Western Blot The expression of RP1-90L14.1 was significantly higher in the LNCaP-AI than in the LNCaP cells .RP1-90L14.1 can promote the expressions of GRIN2A and BACE2 and may have an endogenous competitive relation with GRIN2A and BACE2. No 32216238 LINC01600 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1044 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC01589 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Our experimental results showed lncRNA CTA-941F9.9 to be significantly downregulated in CRC tissues in both cohorts, with areas under the ROC curve (AUC) of 0.802 and 0.876. No 31343781 LINC01572-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01572-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01564 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression(highly expressed) qRT-PCR lncRNA (LINC01564, RAMS11), CBX4, and TOP2A relative expression levels were upregulated in both patient groups compared to controls (p < 0.001*), with the highest levels in the HCC group compared with the CHC group. Additionally, these levels were significantly positively correlated with the clinicopathological features of HCC. No 36672564 LINC01561 LncRNA Homo sapiens Breast Neoplasms BrCa cell lines Expression[highly expressed] qRT-PCR qRT-PCR results identified that in BrCa cell lines, linc01561 and MMP11 were higher expressed while miR-145-5p was lower expressed compared with those in epithelial cell line. No 29890225 LINC01561 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01554 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC cells Interaction(G3BP2) Western Blot//CCK8//qRT-PCR//RIP//RNA-seq//Luciferase Report Assay//EdU Staining//Transwell Assay Mechanistically, LINC01554 maintained the high G3BP2 expression in ESCC by protecting G3BP2 from degradation through ubiquitination and the interaction domains within LINC01554 and G3BP2 were identified. No 34782720 LINC01554 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC specimens Expression(lower expressed) qRT-PCR LINC01554 expressions were strongly downregulated in EOC specimens compared with matched nontumor specimens (p < 0.01). Importantly, LINC01554 provided a high diagnostic performance for the detection of EOC specimens (AUC = 0.7827; p < 0.001). Low expression of LINC01554 was distinctly associated with the FIGO stage (p = 0.034) and distant metastasis (p = 0.007). The assays of survival data (five years) revealed that the 5-year overall survival of the low LINC01554 expression group was distinctly shorter than that of the high LINC01554 expression group (p = 0.0017). No 34422133 LINC01554 LncRNA Homo sapiens Liver Neoplasms HCC tissues,cell lines Expression[lower expressed] Flow Cytometry//qRT-PCR Compared to correspongding adjacent liver tissues, the LINC01554 expression in HCC was significantly down-regulated (P=0.001). And its expression levels in HCC cell lines were also remarkably lower than that in normal human hepatocyte cell line (P<0.001). Besides, the expression level of LINC01554 was significantly related to tumor size, multiple lesions, TNM stages, tumor recurrence rate as well as long-term survival in HCC patients (P<0.05). No 32231743 LINC01550 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[lower expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 LINC01537 LncRNA Homo sapiens Lung Neoplasms Lung Cancer tissues Expression[lower expressed] qRT-PCR Validation analysis confirmed the downregulation of LINC01537 in lung cancer. No 31374807 LINC01537 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HSCC tissues Expression[lower expressed] qRT-PCR The expression level of RP11-169D4.1-001 in HSCC tissues was significantly lower than that in adjacent normal tissues (P = .001). The expression of RP11-169D4.1-001 had no significant relationship with tumor differentiation, stage, smoking, drinking, age, tumor location, or treatment. RP11-169D4.1-001 expression was associated with T category (P = .008) and lymph node metastasis (P = .001). Survival data were assessed by Kaplan-Meier curves. Patients with high RP11-169D4.1-001 expression were found to have a shorter overall survival than patients with low RP11-169D4.1-001 expression. Multivariate analysis also indicated that target RNA was an independent factor for prognosis. The ROC curve was constructed to clarify the diagnostic value of RP11-169D4.1-001. No 31512299 LINC01684-228 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01724-201 LncRNA Homo sapiens Arthritis, Gouty blood Expression[lower expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 LINC01518 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01793 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Expression(highly expressed) qRT-PCR LINC01793 was remarkably upregulated in the HCC tissues and cells. Subsequent analysis revealed that high LINC01793 was related to the Barcelona Clinic Liver Cancer (P = 0.007), tumor invasion (P = 0.042), the number of tumors (P = 0.031) and serum level of alanine aminotransferase(p = 0.022). The areas under the curve of LINC01793, for distinguishing HCC from healthy controls, CHB and LC patients, were 0.824, 0.767 and 0.756, respectively. In addition, the combination of LINC01793 with alpha fetoprotein (AFP) had a stronger diagnostic value than LINC01793 or AFP alone in AFP-negative HCC patients. No 35760369 LINC02145 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissue Interaction[sponging miR-30b-3p] qRT-PCR FLJ33360 expression was significantly downregulated in ovarian cancer tissue (P=0.0011) and was closely associated with International Federation of Gynecology and Obstetrics (FIGO) stage (P=0.027) and recurrence (P=0.002). FLJ33360 is a potential biomarker for early diagnosis and prognostic assessment in ovarian cancer and may regulate the expression of genes by sponging miR-30b-3p and thus participate in the development of ovarian cancer. No 31239715 LINC02108 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC02084 LncRNA Homo sapiens COVID-19 126 blood samples Expression(highly expressed) Bioinformatics Analysis Upon further investigation on an individually selected lncRNA level, some lncRNA genes were significantly enriched in the COVID-19/ICU, while some were enriched in the COVID-19/non-ICU group (Figures 5c and 5d). Selected lncRNAs are presented as violin plots depicting upregulation of LINC02207, AC020636.1, AC243967.2, LINC01127, AC00727.1 and AC092746.1 in the COVID-19/ICU group, whereas those enriched in the COVID-19/non-ICU group include LINC02084, LINC02446, LINC00861, AC015911.3, LINC01871 and ANKRD44-AS1 with ANOVA p values of <0.0001. No 33898797 LINC02076 LncRNA Homo sapiens Neuroblastoma Three independent gene expression datasets Regulation qRT-PCR//Western Blot Four autophagy-related lncRNAs (AL356599.1, AC022075.1, AC020928.1 and LINC02076) were found to be with the best prognostic value and integrated into a four-lncRNA risk signature for predicting PFS of NB patients. The four-lncRNA signature significantly stratify NB patients into two risk groups, with high-risk group has significantly poorer PFS than the low-risk group. No 36530992 LINC02064 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).23). No 33330027 LINC02055-222 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC02046-201 LncRNA Homo sapiens Rhabdomyosarcoma cells Interaction(miR-4443/NUPR1 regulatory axis ) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis Finally, the ENST00000469812/miR-4443/NUPR1 regulatory axis exhibited a positive effect on EV71 replication. No 36269411 LINC02042 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC02015 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC02006 LncRNA Homo sapiens Colorectal Neoplasms 465 CRC patients and 1548 controls Mutation(rs10935945 ) Genotyping The strongest association was observed for rs10935945 in long non-coding RNA LINC02006 (3q25.2). Three other SNPs were also located within genes (rs17575184 in NEGR1, rs11060839 in PIWIL1, rs12935896 in BCAS3), while one was intergenic (rs9927668 at 16p13.2). No 34070617 LINC01995-201 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[highly expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 LINC01990 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01988 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01987 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 LINC01967-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01940 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01929 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR//Microarray The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated). No 32020063 LINC01929 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction( miR-1179) Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay LINC01929 was up-regulated in NSCLC tissues compared with healthy tissues. miR-1179 was a target miRNA of LINC01929. Inhibited expression of LINC01929 significantly reduced the proliferation, migration, and invasion of NSCLC cells by targeting miR-1179. A positive correlation was observed between LINC01929 expression level and tumor T (p = 0.002) or N stage (p = 0.010). Patients with higher LINC01929 levels had shorter overall survival (p = 0.009). Compared with other factors, high LINC01929 expression was significantly associated with poor survival in univariate Cox analysis (HR: 2.485, 95%CI: 1.220-5.060, p = 0.012). No 35996496 LINC01871 LncRNA Homo sapiens COVID-19 126 blood samples Expression(highly expressed) Bioinformatics Analysis Upon further investigation on an individually selected lncRNA level, some lncRNA genes were significantly enriched in the COVID-19/ICU, while some were enriched in the COVID-19/non-ICU group (Figures 5c and 5d). Selected lncRNAs are presented as violin plots depicting upregulation of LINC02207, AC020636.1, AC243967.2, LINC01127, AC00727.1 and AC092746.1 in the COVID-19/ICU group, whereas those enriched in the COVID-19/non-ICU group include LINC02084, LINC02446, LINC00861, AC015911.3, LINC01871 and ANKRD44-AS1 with ANOVA p values of <0.0001. No 33898797 LINC01871 LncRNA Homo sapiens Sjogren's Syndrome SjD cases Expression(highly expressed) RNA-seq//Bioinformatics Analysis LINC01871 was upregulated in all SjD cases. RNA-seq and pathway analyses of LINC01871-/ - cells implicated roles in cytotoxic function, differentiation and IFNγ induction. LINC01871 was induced by IFNγ in a myeloid cell line and regulated by calcineurin/NFAT pathway and T cell receptor (TCR) signalling in primary human T cells. No 36456101 LINC01856 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01840 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LINC01833 LncRNA Homo sapiens Glioblastoma GBM tissues and cells Interaction(miR-623/cyclin D1) BrdU//qRT-PCR//RNA Pull-Down//Western Blot RP11-89 was expressed in high amounts in GBM, while miR-623 was expressed in low amounts in GBM. RP11-89 and miR-623 were not closely correlated, while miR-623 directly bound to RP11-89. RP11-89 and miR-623 showed no direct role in each other's expression. RP11-89 suppressed the role of miR-623 in downregulating cyclin D1 and GBM cell proliferation. No 36066507 LINC01819 LncRNA Homo sapiens Stomach Neoplasms GC tissues Regulation qRT-PCR Following RT‑qPCR validation, AC016735.2, AP001626.1, RP11‑400N13.3 and RP11‑243M5.2 were considered to be consistent with the prediction of the bioinformatics analysis. Transcriptome sequencing and RT‑qPCR experiments identified 4 lncRNAs, including AC016735.2, AP001626.1, RP11‑400N13.3 and RP11‑243M5.2 to have an important role in the carcinogenesis of GC. No 29693709 LINC01814-208 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01811 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial 35 cases of EOC patients (malignant group) and 20 cases of benign ovarian tumor patients (benign group) Expression(highly expressed) qRT-PCR Compared with the benign and normal groups, the expression of FER1L6-AS2, LINC00470 and LINC01811 in malignant group increased by 1.66 and 1.84-fold, 2.05 and 2.46-fold, 2.94 and 2.35-fold, respectively; the expressions of CXXC4-AS1, LINC02343 and LINC02428 were down-regulated to 29% and 34%, 40% and 46%, 42% and 42%, respectively. No 35385957 LINC01806 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Expression [lower expressed] Survival Analysis In this study, autophagy-related mRNAs-lncRNAs were screened from lung adenocarcinoma and a co-expression network of autophagy-related mRNAs-lncRNAs was constructed by using The Cancer Genome Atlas (TCGA). The univariate and multivariate Cox proportional hazard analyses were used to evaluate the prognostic value of the autophagy-related lncRNAs and finally obtained a survival model composed of 19 autophagy-related lncRNAs. No 33987935 LINC01793 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR LINC01793 was overexpressed in gastric cancer tissues compared to paracancerous tissues. Moreover, LINC01793 overexpression in gastric cancer was closely related to patients with poor prognosis. No 29978448 LINC01522-201 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).3). No 33330027 LINC01512 LncRNA Homo sapiens Adenocarcinoma of Lung LAD tissues Regulation[VEGFA/VEGFR2 signaling pathway] qRT-PCR The qPCR results showed that the mRNA expression levels of LOC100132354, VEGFA, VEGFR2, and bFGF mRNA in LAD tissues were significantly increased, while TSP-1 mRNA was significantly decreased compared with the adjacent tissues. These findings suggest VEGFA was a downstream target gene of LOC100132354, promoting angiogenesis through VEGFA/VEGFR2 signaling pathway and downstream target molecules in LAD. No 30323681 LINC01087 LncRNA Homo sapiens Breast Neoplasms TCGA and breast cancer cells Expression [highly expressed] qRT-PCR The qRT-PCR identified 5 lncRNAs with significantly differential expression in breast cancer cells based on the 9 lncRNAs of the prognostic model, and the results were consistent with the tissues. In order to further explore the prognostic value of the 9 lncRNAs, the Kaplan Meier curve was built to confirm the relationship between these lncRNAs and OS. In our analysis, a total of 6 of the 9 lncRNAs (USP30-AS1, ST7-AS1, VPS9D1-AS1, OTUB6DB-AS1, LINC01087, and MAPT-AS1) were identified. The results indicated that the 9 autophagy-related lncRNAs were correlated to the OS in breast cancer patients No 33614483 LINC01219 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01214 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR//Microarray The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated). No 32020063 LINC01213 LncRNA Homo sapiens Prostatic Neoplasms AIPC cell lines Regulation(Wnt/β-catenin) Cell Cycle Assay//Western Blot//qRT-PCR lncRNA sequencing showed that LINC01213 was upregulated in exosomes derived from AIPC cell lines. The rescue experiments were preformed, and the results revealed that most of the functions of LINC01213 were performed by Wnt/β-catenin. No 35310913 LINC01198 LncRNA Homo sapiens Glioma glioma tissues Expression[highly expressed] qRT-PCR LINC01198 was elevated in glioma, and this predicted a poorer prognosis for patients with glioma. No 31469661 LINC01198 LncRNA Homo sapiens Sinusitis cell line Interaction(miR-6776-5p) Bioinformatics Analysis The results of this study showed that LINC01198 promoted the progression of CRSwNPs through spongy miR-6776-5p. No 35572732 LINC01197-215 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01173 LncRNA Homo sapiens Diabetes Mellitus, Type 2 T2DM cases Expression(highly expressed) qRT-PCR The present study observed that the T2DM cases had 6.67-fold increased lncRNA LINC01173 expression compared to healthy controls. It was also observed that the T2DM cases with smoking had a 8.33-fold lncRNA LINC01173 expression while non-smokers had a 5.43-fold lncRNA LINC01173 expression (p<0.0001). Expression of lncRNA LINC01173 was found to be associated with hypertension (p=0.03), wound healing (p=0.04), and blurred vision (p<0.0001). It was observed that the T2DM cases with vitamin-D deficiency had a significant association with fasting glucose level (p=0.01) and HbA1C level (p=0.01) among the T2DM cases. The association of lncRNA LINC01173 with vitamin-D was analyzed and it was observed that the vitamin-D deficient cases had higher lncRNA LINC01173 expression compared to insufficient T2DM cases (p=0.01) and sufficient T2DM cases (p=0.0006). No 36016630 LINC01140 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01139 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung blood Expression[highly expressed] qRT-PCR Plasma levels of LINK-A were found to be significantly higher in patients with different types of metastatic NSCLC than in patients with non-metastatic NSCLC and healthy controls. Plasma levels of LINK-A were lower in patients with metastatic NSCLC on the day of discharge than on the day of admission. Patients with high plasma LINK-A had a higher mortality rate and lower progression-free survival rate within 2 years of discharge. No 31404323 LINC01139 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues Expression[highly expressed] qRT-PCR LINK-A and VEGF were remarkably overexpressed in EOC tissues compared to normal tissues (P value: 0.004, 0.0001, respectively), but we did not find correlation between LINK-A and VEGF RNA expressions in this study. LINK-A was significantly overexpressed in higher stages of cancer and tumor grades. VEGF was only significantly elevated in higher stages. This study confirms importance of novel lncRNA of LINK-A in Iranian EOC patients. No 32333582 LINC01139 LncRNA Homo sapiens Glioma blood Expression[highly expressed] qRT-PCR//ELISA It was observed that the serum levels of LINK-A lncRNA and survivin were significantly higher in patients with glioma compared with healthy controls.Overexpression of LINK-A lncRNA led to increased survivin protein expression, while survivin overexpression had no effect on LINK-A lncRNA expression. No 31410112 LINC01133 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Expression(lower expressed) qRT-PCR//Bioinformatics Analysis According to the qRT-PCR assay, the expression levels of LINC01133 and ZEB1-AS1 were decreased in luminal BC tissues and cell lines. On the other hand, ABHD11-AS1 was upregulated in the above-mentioned samples. The expression levels of LINC01133, ZEB1-AS1, and ABHD11-AS1 were not associated with any of the clinical features. Also, the results obtained from the bioinformatics analyses were consistent with qRT-PCR data. No 34446052 LINC01128-227 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01127 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LINC01124 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and matched adjacent non-tumor tissues Expression[lower expressed] qRT-PCR//Wound Healing Assay//Transwell Assay The qRT-PCR was used to detect the expression levels of LINC01124 in cancer tissue and adjacent normal tissue from NSCLC samples. Results showed that the LINC01124 expression levels in lung cancer tissue were significantly lower than normal tissue No 32099381 LINC01123 LncRNA Homo sapiens Adenocarcinoma of Lung cell lines regulation[NOTCH signaling pathway] RNA Pull-Down//ChIP//Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining//IF We explored the differential expression of LINC01123 through qRT-PCR and found the amplification of LINC01123 in LUAD cell lines.Altogether, ZEB1-activated LINC01123 accelerates the malignancy in LUAD through miR-449b-5p/NOTCH1 axis-mediated NOTCH signaling pathway, while NOTCH1 boosts ZEB1 in return. These observations suggest the huge potential of LINC01123 as a new target for LUAD therapy. No 33191397 LINC01122-207 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01116 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue and adjacent nontumor tissue Regulation(EMT and immune regulation ) qRT-PCR A 5-lncRNA signature was developed for HCC and its prognostic accuracy was assessed by survival, time-dependent receiver operating characteristic curve, clinical correlation, and Cox regression analyses. The correlation analysis showed that the lncRNA signature was closely related to immune cell infiltration and 10 immune checkpoint targets and also predicted the prognosis of HCC patients with high accuracy. In vitro and in vivo experiments revealed that LINC01116 stimulated cell proliferation, cell cycle progression, and tumor metastasis. We also found that LINC01116 was closely related to immune regulation. A 5-lncRNA signature was developed for HCC and its prognostic accuracy was assessed by survival, time-dependent receiver operating characteristic curve, clinical correlation, and Cox regression analyses. The correlation analysis showed that the lncRNA signature was closely related to immune cell infiltration and 10 immune checkpoint targets and also predicted the prognosis of HCC patients with high accuracy. No 35148283 LINC01116 LncRNA Homo sapiens Glioma glioma tissues Interaction[targeting VEGFA] RNA Pull-Down//Microarray Our microarray study showed that lncRNA-LINC01116 was significantly upregulated in glioma tissues and played an important role in cell proliferation, cycle, migration, invasion and angiogenesis.Dual luciferase assay showed that LINC01116 and VEGFA both contained a miR-31-5p binding site, and LINC01116 could regulate the expression of VEGFA through competitive absorption of miR-31-5p. RNA immunoprecipitation indicated that LINC01116 and VEGFA were present in the miR-31-5p-RISC complex, and biotinylated miR-31-5p pull-down assay suggested that there was a competitive relationship between LINC01116 and VEGFA to bind with miR-31-5p. No 31144303 LINC01116 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Expression [highly expressed] Survival Analysis In this study, autophagy-related mRNAs-lncRNAs were screened from lung adenocarcinoma and a co-expression network of autophagy-related mRNAs-lncRNAs was constructed by using The Cancer Genome Atlas (TCGA). The univariate and multivariate Cox proportional hazard analyses were used to evaluate the prognostic value of the autophagy-related lncRNAs and finally obtained a survival model composed of 18 autophagy-related lncRNAs. No 33987935 LINC01102 LncRNA Homo sapiens acral lentiginous melanoma tumor and six adjacent non-tumor tissues Expression[highly expressed] qRT-PCR//Microarray The top 5 upregulated lncRNAs were T380070, ENST00000554431, T097678, GSE61474_TCONS_00183926 and NR_015403. No 31966073 LINC01095 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01094 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression(highly expressed) Bioinformatics Analysis LINC01094 expression was upregulated in gastric cancer tissues and strongly associated with overall survival using univariate Cox regression (hazard ratio [HR] = 1.476, 95% CI = 1.060-2.054, P = .021) and multivariate Cox regression analysis (HR = 1.535, 95% CI = 1.021-2.308, P = .039). LINC01094 expression was upregulated in gastric cancer tissues and strongly associated with overall survival using univariate Cox regression (hazard ratio [HR] = 1.476, 95% CI = 1.060-2.054, P = .021) and multivariate Cox regression analysis (HR = 1.535, 95% CI = 1.021-2.308, P = .039). No 35254147 LINC01091-217 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01091-208 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01090 LncRNA Homo sapiens Adenocarcinoma of Lung TCGA(LUAD cancer and normal samples) Regulation Survival Analysis Herein, we identified an eight-lncRNA signature (PR-lncRNA signature, NPSR1-AS1, SATB2-AS1, LINC01090, FGF12-AS2, AC005256.1, MAFA-AS1, BFSP2-AS1, and CPC5-AS1), which contributes to predicting LUAD patient's prognosis risk and survival outcomes. Of them, NPSR1-AS1, SATB2-AS1, FGF12-AS2, and AC005256.1 could be acted as the poor prognosis markers, while LINC01090, MAFA-AS1, BFSP2-AS1, and CPC5-AS1 were treated as the protective factors for survival in LUAD patients. No 34550610 LINC01089 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01088-214 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01088-206 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01218 LncRNA Homo sapiens Myelodysplastic Syndromes bone marrow Expression[highly expressed] qRT-PCR//Microarray Of the functionally described lncRNAs, we detected the upregulation of H19, EMCN-IT1, WT1-AS, MEG8, and PVT1 and the downregulation of ST6GAL2-IT1 and U4. No 32977510 LINC01220 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LINC01507 LncRNA Homo sapiens Uterine Cervical Neoplasms plasma Expression[highly expressed] qRT-PCR We discovered 4 lncRNAs including HOTAIR, PVT1, XLOC_000303, and AL592284.1, which were upregulated in CC comparing with the cancer-free controls. No 30134241 LINC01227 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01504 LncRNA Homo sapiens Arthritis, Rheumatoid peripheral blood mononuclear cells Expression[lower expressed] qRT-PCR//RNA-seq In the present study, 231 upregulated and 110 downregulated lncRNAs were identified as differentially expressed in patients with RA compared with the controls. Information on the top 6 up- or downregulated lncRNAs is provided in Table III. No 33456537 LINC01503 LncRNA Homo sapiens Glioblastoma tumor tissues and cells Interaction(GLI2/FBXW1/ Wnt/β-catenin signaling ) qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis//FISH The results showed that ENST00000444125 was the dominant transcript of LINC01503 in both normal and tumor tissues. Its expression was significantly elevated in the tumor group and associated with poor survival outcomes. RNA pull-down and RIP-qPCR assay confirmed an interaction between ENST00000444125 and GLI2. ENST00000444125 positively regulated the half-life of the GLI2 protein in GBM cells. ENST00000444125 overexpression reduced GLI2 ubiquitination and partially attenuated FBXW1 overexpression induced GLI2 ubiquitination. ENST00000444125 overexpression could activate Wnt/β-catenin signaling in GBM cells. No 34990616 LINC01485 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Expression(lower expressed) qRT-PCR In the validation tissue sample set, FOXD3-AS1 was down-regulated in colorectal cancer tissues (P < 0.001), while LINC01485 was up-regulated in colorectal cancer tissues compared with the adjacent tissues (P < 0.05). LINC01485 is significantly related to the clinical staging, lymph node metastasis, and distant metastasis of colorectal cancer. No 35033545 LINC01480 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[highly expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 LINC01479 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 546 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC01475 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 LINC01473 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 963 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC01433 LncRNA Homo sapiens Lung Neoplasms Lung Cancer tissues Expression[no differently] qRT-PCR There was no significant difference in the expression of LINC01433 between tumoral and non-tumoral tissues (expression ratio 0.67, p = 0.42). No 31842564 LINC01429 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01428 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1012 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC01415 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 LINC01413 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[ LINC01413/hnRNP-K/TAZ1/YAP1/ZEB1 axis] RNA Pull-Down//Western Blot//Co-IP//qRT-PCR//RIP//FISH//MTT//Luciferase Report Assay//Microarray//Transwell Assay//IF In this study, we recognize a novel lncRNA called LINC01413 that is upregulated in CRC tissues through lncRNAs microarray. Taken together, this research suggested LINC01413 as a positive regulator in CRC progression through the LINC01413/hnRNP-K/TAZ1/YAP1/ZEB1 axis, broadening a new view on CRC treatment. Subsequently, we confirmed that an elevated level of LINC01413 expression in CRC tissues was strongly correlated to clinicopathological features, such as tumor size, tumor stage, lymph node metastasis, and distant metastasis, and its association with poor overall survival was also revealed. No 31927328 LINC01410 LncRNA Homo sapiens Glioblastoma GBM tissues and cells Expression(highly expressed) Western Blot//Transfection//CCK8//RIP//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis LINC01410 expression was upregulated in GBM, and silencing of LINC01410 decreased cell viability. No 34435542 LINC01410 LncRNA Homo sapiens Endometrial Neoplasms EC tissues regulation[miR-23c/CHD7 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Our data illustrated that LINC01410 high expression was presented in EC tissues and was positively related to the poor prognosis of patients in EC, as well as the malignant behaviors of EC cells. Our results indicated that high expression of LINC01410 promoted EC cell progression through modulating miR-23c/CHD7 axis, providing a new direction for revealing the molecular mechanism of EC. Our data illustrated that LINC01410 high expression was presented in EC tissues and was positively related to the poor prognosis of patients in EC, as well as the malignant behaviors of EC cells. No 32314193 LINC01389 LncRNA Homo sapiens Stomach Neoplasms eighty-three GC tissues Expression(highly expressed) qRT-PCR The significant downregulation of LINC00365 (66.3%) and RP11-354K4.2 (62.7%) were observed in GC samples; while the upregulation of LINC01389, RP11-138J23.1, TWIST1, MMP13, MAML1, CD44s, and SALL4 were found in 67.5%, 45.8%, 56.6%, 44.6%, 59%, 55.4%, and 62.7% tumors samples at the mRNA level, respectively. No 36208698 LINC01372 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1008 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC01356 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung H1299 cells Expression(highly expressed) qRT-PCR//Western Blot//Invasion Assay//Transwell Assay LncRNA LINC01356 was significantly upregulated in H1299 cells and exosomes derived from these cells compared to that of A549 cells. In addition, BMECs treated with LINC01356-deprived exosomes expressed higher junction proteins than those treated with the control exosomes, and silencing LINC01356 in exosomes derived from H1299 cells could inhibit A549 cells from crossing the BBB. Moreover, LINC01356 was also upregulated in serum exosomes of patients with NSCLC with brain metastasis compared with those without metastasis. No 35574344 LINC01343 LncRNA Homo sapiens Breast Neoplasms GSE71053 dataset Expression(highly expressed) qRT-PCR//Bioinformatics Analysis CCDC18-AS1, LINC01343, and SFN were expressed higher in BC than in the control (normal paired) tissues based on qRT-PCR data. The investigation of clinicopathological parameters showed that SFN was highly expressed in tumor size of <5 cm and in nonmenopausal ages, while CCDC18-AS1 and LINC01343 indicated a high expression in stages II-III and III of BC, respectively. The overall survival analysis displayed high and low survival in patients with high expression of SFN and CCDC18-AS1, respectively. The ROC curve analysis disclosed that SFN, CCDC18-AS1, and LINC01343 might be suggested as potential biological markers in BC patients. No 36160032 LINC01315 LncRNA Homo sapiens Breast Neoplasms 282 breast cancer tissues Regulation qRT-PCR Our study revealed that Linc01315 expression level was significantly correlated with vessel invasion (P = 0.028) and tumor subtype (P = 0.039). The Kaplan-Meier survival curves demonstrated that patients with lower Linc01315 expression level had significantly longer disease free survival (DFS) (P = 0.002) and overall survival (OS) (P=0.019). No 34676156 LINC01305 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[TNXB-mediated PI3K/Akt signaling pathway] CCK8//qRT-PCR//Transwell Assay LINC01305 had an obviously higher expression in NSCLC tissues, and the expression in lung cancer patients with tumor size >3 cm was higher than those with tumor ≤3 cm. LINC01305 had an obviously higher expression in NSCLC tissues, and the expression in lung cancer patients with tumor size >3 cm was higher than those with tumor ≤3 cm. LINC01305 expression in tumor tissues in T3-T4 stage was obviously higher than those in T1-T2 stage, and the overall survival rate of lung cancer patients with high expression of LINC01305 was lower than those with low expression. Moreover, clinical analysis revealed that LINC01305 level was related to tumor size, TNM stage and lymph node metastasis of patients with lung cancer, but not related to age or gender. No 32549529 LINC01301 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 916 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC01288 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[stabilizing IL-6] CCK8 We found that LINC01288 is frequently Expression[up-expression]regulated in NSCLC samples and cell lines.LINC01288 physically interacts with the IL-6 mRNA and increase the stability of IL-6 transcripts. Subsequently, the autocrine induction of IL-6 and enhanced STAT3 activation may facilitate NSCLC progression. No 31054777 LINC01278-226 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC01266 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01250 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 LINC01235 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC01234 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR Consequently, at the end of research we found LINC01234 is up-regulated in GC tissues in comparison with adjacent normal tissues. No 32011780 LINC01230 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[highly expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 LINC00467 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Epigenetics(DNA copy number amplification and hypomethylation ) qRT-PCR//Transfection//Bioinformatics Analysis LINC00467 is a novel lncRNA that is abnormally expressed in several cancer types including LUAD. In this study, based on The Cancer Genome Atlas data mining, we demonstrated that DNA copy number amplification and hypomethylation was positively correlated with LINC00467 expression in LUAD. No 35095769 LINC00467 LncRNA Homo sapiens Vogt-Koyanagi-Harada disease Mutation(Rs12569232) Genotyping//FISH//qRT-PCR//Cell Proliferation Assay//ELISA The rs12569232 was associated with the expression of linc00467. The expression of linc00467 was up-regulated in PBMCs and CD4+T cells from VKH disease and BD patients. No 32400232 LINC00461 LncRNA Homo sapiens Rectal Neoplasms rectal cancer cells Expression[highly expressed] qRT-PCR Data from this study revealed that LINC00461 expression was upregulated in rectal cancer cells. No 31972361 IGFBP7-AS1 LncRNA Homo sapiens uterine corpus endometrial carcinoma tumor tissues Interaction(IGFBP7) qRT-PCR//Survival Analysis IGFBP7 Antisense RNA 1 (IGFBP7-AS1) was identified as the key eRNA for its expression patterns of low levels in tumor tissues and favorable prognostic value in UCEC correlated with its target gene IGFBP7. In RT-qPCR analysis, IGFBP7-AS1 and IGFBP7 had down-regulated expression in tumor tissues, which was consistent with previous analysis. No 35836132 IGF2BP3 LncRNA Homo sapiens Sarcoma, Ewing populations Mutation(rs112316332, rs13242065, rs12700421) Genotyping An association between polymorphisms and EWS susceptibility was observed for three IGF2BP3 SNPs - rs112316332, rs13242065, rs12700421 - and for four SENCR SNPs - rs10893909, rs11221437, rs12420823, rs4526784 -. In addition, IGF2BP3 rs34033684 and SENCR rs10893909 variants increased the risk for female respect to male subgroup when carried together, while IGF2BP3 rs13242065 or rs76983703 variants reduced the probability of a disease later onset (> 14 years). Moreover, the absence of IGF2BP3 rs10488282 variant and the presence of rs199653 or rs35875486 variant were significantly associated with a worse survival in EWS patients with localized disease at diagnosis. No 36338681 IGF2-AS LncRNA Homo sapiens Hepatitis B virus HCC tissues Expression[highly expressed] qRT-PCR Our data showed that the level of IGF2AS in liver cancer tissues of HBV-related HCC was significantly higher than that in the adjacent non-cancerous tissues. Meanwhile, the serum level of IGF2AS in the HBV-related HCC group was higher than that in healthy control group, chronic HBV group, and HBV-related cirrhosis. Moreover, serum IGF2AS in patients with HBV-related HCC gradually increased in groups A, B, C, and D of HBV-re-lated HCC patients according to BCLC classification. Further analysis showed that serum IGF2AS levels were increased in both AFP-negative HCC patients and AFP-positive HCC patients compared to that in HBV-related cirrhosis patients, suggesting that serum IGF2AS can be used in early identification and diagnosis of HBV-related HCC irrespective of AFP levels. No 31850718 IGBP1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 IFTAP LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 IFT140-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 IFNG-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate tissues and control samples Expression[lower expressed] qRT-PCR Our results showed that NeST lncRNA was significantly up-regulated in prostate cancer samples compared to control, while NeST lncRNA and IFN-ɣ gene expression was detected mainly in early stages of prostate cancer. The patients with higher NeST and FOXCUT expression had poor clinical features including PSA levels and tumor volume comparing those with lower expression. No 31710451 IFNG-AS1 LncRNA Homo sapiens Multiple Sclerosis blood Expression[highly expressed] qRT-PCR APOA1-AS, IFNG-AS1, SPHK1 & 2, and S1PR5 were upregulated in RRMS patients. No 32071782 IFNG-AS1 LncRNA Homo sapiens Coronary Artery Disease Blood Expression[highly expressed] qRT-PCR LncRNA IFNG-AS1 relative expression in CAD patients was upregulated compared with that in controls (P < .001), and the receiver operating characteristic (ROC) curve showed that the area under curve (AUC) of lncRNA-IFNG-AS1 for predicting the risk of CAD was 0.755 (95% CI: 0.688-0.821). lncRNA IFNG-AS1 relative expression was remarkably associated with Gensini Score (r = .259, P = .009). No 29744951 IFNG-AS1 LncRNA Homo sapiens Coronary Artery Disease 40 CAD patients and 40 healthy individuals Expression(lower expressed) qRT-PCR The expressions of IFNG-AS1 lncRNA as well as IFN-γ and ZEB2 genes were significantly reduced in CAD patients compared to healthy subjects. In contrast, the expression of ZEB2-AS1 was up-regulated in these patients. Linear regression analysis unveiled that there is a positive correlation between the expression of IFNG-AS1 and IFN-γ, also similarly, ZEB2-AS1 and ZEB2 in PBMCs of subjects. Moreover, the expression of IFNG-AS1 and ZEB2-AS1 correlated with the Gensini score. No 35389131 IFNG-AS1 LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 IFNG-AS1 LncRNA Homo sapiens Purpura, Thrombocytopenic, Idiopathic blood samples from children with ITP Expression(highly expressed) qRT-PCR There were overexpressed lncRNAs IFNG-AS1 and GAS5 in serum of childhood ITP patients [(median (IQR) = 3.08 (0.2-22.39) and 4.19 (0.9-16.91) respectively, Also, significant higher IFNG-AS1 and GAS5 (p < 0.05) were present in persistent ITP (3-12 months) [ median (IQR) = 4.58 (0.31-22.39) and 3.77 (0.87-12.36) respectively] or chronic ITP (>12 months) [ median (IQR) = 5.6 (0.25-12.59) and 5.61 (1.15-16.91) respectively] when compared to newly diagnosed <3 months patients [IFNG-AS1 median (IQR) = 1.21 (0.2-8.95), and GAS5 median (IQR) = 1.07 (0.09-3.55)] No 36310591 IFITM4P LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OL and OSCC samples Regulation(PD-L1) qRT-PCR//RNA Pull-Down Based on microarray analysis of genes expressed in OL and OSCC samples, we discovered that the long non-coding RNA IFITM4P was highly expressed in OSCC, and ectopic expression or knockdown of IFITM4P resulted in increased or decreased cell proliferation in vitro and in xenografted tumors, respectively. Mechanistically, in the cytoplasm IFITM4P acted as a scaffold to facilitate recruiting SASH1 to bind and phosphorylate TAK1 (Thr187), and in turn to increase the phosphorylation of nuclear factor κB (Ser536) and concomitant induction of PD-L1 expression, resulting in activation of an immunosuppressive program that allows OL cells to escape anti-cancer immunity in cytoplasm. In nucleus, IFITM4P reduced Pten transcription by enhancing the binding of KDM5A to the Pten promoter, thereby upregulating PD-L1 in OL cells. Moreover, mice bearing tumors with high IFITM4P expression had notable therapeutic sensitivity to PD-1 monoclonal antibody (mAb) treatment. Collectively, these data demonstrate that IFITM4P may serve as a new therapeutic target in blockage of oral carcinogenesis, and PD-1 mAb can be an effective reagent to treat OSCC. No 35051616 IFI44 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 IFI27-205 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 IDH3B CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ID2-AS1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 ICR LncRNA Homo sapiens Carcinoma, Hepatocellular serum Expression(highly expressed) qRT-PCR The serum levels of HOTAIR, BRM and ICR were significantly higher in HCC patients compared to LC patients and healthy subjects. The HOTAIR level was positively correlated to tumour-node metastasis (TNM), Barcelona Clinic Liver Cancer (BCLC) stage, extrahepatic metastasis, vascular invasion, portal vein tumour thrombus (PVTT), and tumour size. No 36224021 IARS1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 IARS1 CircRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues and plasma exosomes Expression[highly expressed] PCR//Western Blot circ-IARS expression was up-regulated in pancreatic cancer tissues and in plasma exosomes of patients with metastatic disease. Circ-IARS was found to enter HUVECs through exosomes and promote tumor invasion and metastasis. Circ-IARS expression was positively correlated with liver metastasis, vascular invasion, and tumor-node-metastasis (TNM) stage and negatively correlated with postoperative survival time. No 30064461 HYMAI LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 669 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 HULC LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)8) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 HULC LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[lower expressed] qRT-PCR HULC, OIP5-AS1 and THRIL transcription quantities were significantly lower in gastric tumors compared to ANCTs (P values = .02, 0.02 and 0.007, respectively). No 31982396 HULC LncRNA Homo sapiens Breast Neoplasms breast cancer tissues and cell lines Interaction[Sponging miR-6754-5p] qRT-PCR In this study, we found that lncRNA HULC was overexpressed in breast cancer tissues and cell lines compared to normal healthy breast tissues and normal breast cell line. Mechanically, we found that HULC can bind to miR-6754-5p directly through complementary base pairing. Furthermore, we found that HULC regulates the expression of LYPD1 through sponging miR-6754-5p. Moreover, overexpression of LYPD1 can rescue the migration and invasion abilities of breast cancer cells decreased by knockdown of HULC or overexpression of miR-6754-5p. Moreover, the high expression of HULC was associated with metastasis and malignancy of breast cancers. No 31824174 HULC LncRNA Homo sapiens Breast Neoplasms breast cancer cells Regulation( IGF1R-PI3K-AKT axis ) Western Blot//Migration Assay//CCK8//qRT-PCR//Cell Cycle Assay//ChIP We identified lncRNA HULC (Highly Upregulated in Liver Cancer) as a key trans-regulator of IGF1R in breast cancer cells. Loss of HULC suppressed the expression of IGF1R and the activation of its downstream PI3K/AKT pathway, while HULC overexpression activated the axis in breast cancer cells. Using a transcription-associated trap (RAT) assay, we demonstrated that HULC functioned as a nuclear lncRNA and epigenetically activated IGF1R by directly binding to the intragenic regulatory elements of the gene, orchestrating intrachromosomal interactions, and promoting histone H3K9 acetylation. The activated HULC-IGF1R/PI3K/AKT pathway mediated tumor resistance to cisplatin through the increased expression of cancer stemness markers, including NANOG, SOX2, OCT4, CD44 and ALDH1A1. No 35981570 HULC LncRNA Homo sapiens Osteoarthritis OA cartilage tissues Interaction[repression of miR-101] qRT-PCR Interesting results showed that the expression level of HULC was significantly down-regulated in OA cartilage tissue compared with that in NT group.The discoveries testified that HULC protected ATDC5 cells against TNF-α-induced inflammatory injury by repression of miR-101. No 30981080 HULC LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Regulation[downregulating miR-29] CCK8//qRT-PCR//IHC//Luciferase Report Assay The expression of HULC was significantly up-regulated while the expression of miR-29 was significantly down-regulated in HCC tissues and cells (P<0.01). No 31550855 HULC LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR The levels of serum HULC, MALAT1, Linc00152, PTTG3P, SPRY4-IT1, UBE2CP3, and UCA1 were significantly higher in HCC patients than in patients with benign liver diseases and healthy controls, whereas serum PTENP1 was significantly decreased in HCC patients compared with healthy participants. No 32733618 HULC LncRNA Homo sapiens Glioblastoma GBM tissues Regulation(up regulation) In Vivo Experiment//Western Blot//Tube Formation Assay//qRT-PCR//IHC//Invasion Assay//Transwell Assay No 34213079 HULC LncRNA Homo sapiens acute myocardial infarction 80 AMI patients and 36 healthy volunteers Regulation qRT-PCR ROC analysis reveals the superiority of TTTY15 and HULC as biomarkers against conventional AMI biomarkers CKMB (AUC of TTTY15: 0.915 versus CKMB: 0.768 versus TnT: 0.869); AUC of HULC: 0.905 versus CKMB: 0.768 versus TnT: 0.869). Regression and correlation analysis indicates that TTTY15 and HULC may be one of the contributing factors to AMI and related to accepted risk factors. ROC analysis reveals the superiority of TTTY15 and HULC as biomarkers against conventional AMI biomarkers CKMB (AUC of TTTY15: 0.915 versus CKMB: 0.768 versus TnT: 0.869); AUC of HULC: 0.905 versus CKMB: 0.768 versus TnT: 0.869). Regression and correlation analysis indicates that TTTY15 and HULC may be one of the contributing factors to AMI and related to accepted risk factors. No 35246050 IGFBP7-202 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 IGFL2-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer cells Expression [lower expressed] Wound Healing Assay//RNA-seq//Bioinformatics Analysis Among the 61 lncRNAs, IGFL2-AS1 was the most significantly decreased. Our results indicate that this lncRNA plays a role in downregulating its nearest neighbor, IGFL1, and affects migration of breast cancer cells. No 28488769 HULC LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR LncRNA HULC expression was increased in sepsis patients compared with controls. Furthermore, in sepsis patients, lncRNA HULC expression was positively correlated with acute physiology and chronic health evaluation II score and sequential organ failure assessment score, but not correlated with primary infection sites or primary infection organisms; meanwhile, lncRNA HULC expression was increased in deaths compared with survivors; subsequent receiver operating characteristic curve indicated that lncRNA HULC presented good value in predicting increased 28-day mortality (AUC: 0.785, 95% CI: 0.713-0.857), and its independent predictive value for mortality was also verified by multivariate analysis. No 33314296 IGHA1 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[highly expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 4 No 32547537 ITCH LncRNA Homo sapiens Melanoma melanoma tissues Interaction[downregulates GLUT1 ] CCK8//qRT-PCR//Western Blot ITCH overexpression resulted in the downregulation of GLUT1 and suppressed glucose uptake in melanoma.GLUT1 overexpression promoted glucose uptake but failed to affect ITCH. ITCH overexpression resulted in increased, while GLUT1 overexpression resulted in decreased rate of melanoma cell proliferation. In addition, GLUT1 overexpression reduced the effects of ITCH overexpression on cell proliferation. No 31403357 IRF1-AS LncRNA Homo sapiens Peste-des-Petits-Ruminants PPR virus Regulation(IFN-β and ISG) qRT-PCR//IF//IP//Western Blot Furthermore, we identified a system of lncRNAs related to the immune response and focused on the role of lncRNA 10636385 (IRF1-AS) in regulating the innate immune response. Interestingly, we found that IRF1-AS was a potent positive regulator of IFN-β and ISG production, which can significantly inhibit PPRV replication in host cells. In addition, our data revealed that IRF1-AS was positively correlated with its potential target gene, IRF1, which enhanced the activation of IRF3 and the expression of ISGs and interacted with IRF3. No 36307867 IQUB LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 IQCJ-SCHIP1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 IQCH-AS1 LncRNA Homo sapiens Endometrial Neoplasms Serum and tissue samples Expression(lower expressed) RNA-seq At the same time, lncRNA sequencing results showed that when endometrial atypical hyperplasia continued to change, including LINC00511, PVT1, and IQCH-AS1 (downregulated), and only changed significantly in the endometrial dysplasia group, including MALAT1, CARMN (downregulated) and LINC00648, BISPR, LINC01534, and LINC00930 (upregulated). No 36510632 IQANK1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and corresponding para-tumorous Expression[highly expressed] qRT-PCR FAM83H-AS1 in GC tissues was aberrantly overexpressed than that of paired non-tumorous tissues No 31493939 IQANK1 LncRNA Homo sapiens Breast Neoplasms Serum Expression[highly expressed] qRT-PCR We found that FAM83H-AS1 and lncRNA-ATB were significantly overexpressed in sera of breast cancer patients compared to controls (p = 0.000 for both). No 32763293 IQANK1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues regulation[miR-10a-5p/Girdin axis] Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay In the present study, FAM83H-AS1 was observed to be significantly up-regulated in ESCC tissues and was associated with TNM stage, pathological differentiation and lymph node metastasis. Furthermore, FAM83H-AS1 could act as competing endogenous RNA to affect the expression of Girdin by sponging miR-10a-5p verified by RIP and luciferase reporter assays. In the present study, FAM83H-AS1 was observed to be significantly up-regulated in ESCC tissues and was associated with TNM stage, pathological differentiation and lymph node metastasis. No 32583631 IQANK1 LncRNA Homo sapiens Ovarian Neoplasms OC tissues Epigenetics(methylation ) qRT-PCR Specially, expression of FAM83H-AS1 was higher in OC and showed difference in diverse stages. There were two methylation sites including cg01399317 and cg20519035 located at FAM83H-AS1. The methylation level of cg01399317 was correlated with gene expression of FAM83H-AS1. The expression level of FAM83H-AS1 was correlated with infiltration level of immune cell including macrophage, neutrphil and dendritic cell in OC patients. Lastly, qRT-PCR showed that the expression of FAM83H-AS1 was higher in OC tissues than normal control tissues. High FAM83H-AS1 expression is associated with worse pan-cancer and OC outcomes. No 33413565 IPW LncRNA Homo sapiens Thyroid cancer, medullary medullary thyroid tumor tissues Expression [highly expressed] qRT-PCR Here we have tested three up-regulated (RMST, FTX, IPW) and one down-regulated (RMRP) lncRNAs in our samples (formalin fixed paraffin embedded tissues from twenty-one MEN2 and ten sMTC patients) by RT-qPCR analysis. No 33407723 IPO8 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 INTS8 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 IMMTP1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 559 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 IL7R LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 IL7R LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 IL7R LncRNA Homo sapiens Wounds and Injuries trauma patients Expression(lower expressed) qRT-PCR The lnc-IL7R levels were significantly lower in trauma patients, especially in those with severe trauma [Injury Severity Score (ISS) ≥ 16], and correlated negatively with the ISS, Acute Physiology and Chronic Health Evaluation II score, and length of ICU stay. The lnc-IL7R levels were also significantly decreased in patients who developed MODS than in those who did not. Lnc-IL7R was an independent predictor of MODS [odds ratio (OR) 0.654, (0.435-0.982), p = 0.041]. The area under the curve for predicting post-traumatic MODS was 0.799 (sensitivity 76.9%, specificity 71.4%), with a cutoff value of 0.024. No 32524156 IL6 LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-14A) Expression[highly expressed] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD8 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 IL21-AS1 LncRNA Homo sapiens Lupus Erythematosus, Systemic CD4+ T cells of SLE patients and Tfh cells Regulation(IL21 ) Flow Cytometry We uncovered that IL21-AS1 was highly expressed in CD4+ T cells of SLE patients and Tfh cells, which promoted differentiation of Tfh cells. Mechanistically, IL21-AS1 bound heterogeneous nuclear ribonucleoprotein U and recruited acetyltransferases CREB-binding protein to the promoter of IL21, leading to the transcriptional activation of IL21 and Tfh cells differentiation through increasing Histone H3 acetylation level on IL21 promoter. Moreover, Tfh proportion and antibodies production were significantly increased in mIl21-AS knock-in mice immunized with KLH. mIl21-AS1 overexpression also exacerbated the lupus-like phenotype in cGVHD mice model. No 36447054 IL1R2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 IL12RB2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 IL12A-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 IK-209 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 IK-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 IGSF9B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 IGSF9B LncRNA Homo sapiens Glioma cell lines Regulation[MIR4697HG/miR-766-5p/PRR12 axis ] RNA Pull-Down//qPCR//Luciferase Report Assay//RIP The expression of MIR4697HG is down-regulated significantly in glioma cells due to the up-regulated expression of RAD21. The MIR4697HG/miR-766-5p/PRR12 axis predicts poor results in glioma and MIR4697HG could be considered as a promising biomarker for diagnosis and treatment of glioma. No 31884342 IGSF9B LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[lower expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 IGLL3P LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)64) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 IGKV2-29 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[highly expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 2 No 32547537 IGHJ3P LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[highly expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 1 No 32547537 HULC LncRNA Homo sapiens Ischemic Stroke blood regulation[ IL-6, ICAM1, miR-9, and miR-195] qRT-PCR LncRNA HULC is correlated with higher AIS risk, increased disease severity and worse prognosis in AIS patients. Meanwhile, it associates with higher IL-6, elevated ICAM1, and lower miR-9 AIS patients. LncRNA HULC is correlated with higher AIS risk, increased disease severity and worse prognosis in AIS patients. No 32815572 HULC LncRNA Homo sapiens Sepsis blood regulation[HULC/miR-128-3p/RAC1 axis ] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP HULC and RAC1 were found to be upregulated, and miR?128?3p was downregulated in the serum of patients with sepsis and LPS?stimulated HMEC?1 cells.In conclusion, HULC knockdown partially reversed LPS‑induced sepsis via the regulation of miR‑128‑3p/RAC1 axis. No 33174038 ITGA2 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 HOXA11-AS LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[miR-148a/WNT1/β-catenin pathway ] qRT-PCR//Luciferase Report Assay//RIP//Transwell Assay Results showed that HOXA11-AS and WNT1 expression levels were upregulated, while miR-148a level was downregulated in GC tissues and cell lines relative to matched controls.In conclusion, overexpression of HOXA11-AS contributed to migration and invasion of GC cells via activation of WNT1/β-catenin signaling pathway through repressing miR-148a, providing a prospective therapeutic target for GC. Elevated expression of HOXA11-AS was associated with increased tumor size, lymph node metastasis, advanced TNM stage, as well as reduced survival of GC patients. No 32009419 HOXA11-AS LncRNA Homo sapiens Colorectal Neoplasms CRC samples interaction[sponging miR-149-3p] qRT-PCR//Luciferase Report Assay//Western Blot The expression of HOXA11-AS in the CRC tissue is significantly higher than the expression in adjacent noncancerous tissue (p<0.0001). This study demonstrates that high expression of HOXA11-AS is correlated with CRC progression and poor prognosis and may promote metastasis via EMT by modulating miR-149-3p. High expressions of HOXA11-AS were noticeably correlated with clinicopathologic characteristics including advanced clinical stage (p=0.021), larger tumor size (p<0.001) and frequent tumor recurrence (p=0.001). The overall survival in HOXA11-AS-High group was significantly shorter than the HOXA11-AS-Low group (p<0.001). Advanced clinical stage, tumor size and high expression of HOXA11-AS were showed as independent prognostic prediction factors for the 5-year tumor relapse of CRC patients (p<0.001). No 32922545 HOXA11-AS LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Expression[highly expressed] qRT-PCR HOXA11-AS expression was increased in OSCC clinical tissues and cell lines and upregulated in CDDP-resistant cells. No 31275988 HOXA11-AS LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC cell lines Interaction(NQOs) In Vivo Experiment//qRT-PCR Using the human OSCC cell lines HSC3 and HSC4, we demonstrate that HOXA11-AS promotes NQO1 expression by sponging microRNA-494. In contrast, HOXA11-AS recruits zeste homolog 2 (EZH2) to the NQO2 promoter to suppress its expression via the trimethylation of H3K27. The upregulation of NQO1 enzymatic activity by HOXA11-AS results in the consumption of flavin adenine dinucleotide (FAD), which reduces FAD-requiring glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity and suppresses glycolysis. Our analyses showed that HOXA11-AS expression in human OSCC cases correlates with lymph node metastasis, nicotinamide adenine dinucleotide (NAD)(P)H: quinone oxidoreductase 1 (NQO1) upregulation, and dihydronicotinamide riboside (NRH): quinone oxidoreductase 2 (NQO2) downregulation. No 36142607 HOXA11-AS LncRNA Homo sapiens Uterine Cervical Neoplasms cervical carcinoma tissues Expression[lower expressed] qRT-PCR//Microarray CACX is one of the most common cancer affecting women world-wide. Here, expression microarray analysis revealed 8 over-expressed transcribed pseudogenes (GBP1P1, HLA-DRB6, HLA-H, SLC6A10P, NAPSB, KRT16P2, PTTG3P and RNF126P1), down-regulated 7 lincRNAs (H19, MIR100HG, MEG3, DIO3OS, HOXA11-AS, CD27-AS1 and EPB41L4A-AS) and 6 snoRNAs (SNORD97, SNORD3A, SNORD3C, SNORD3D, SNORA12 and SCARNA9) as DEncGs (log2 fold-change ≥ ±1.0) in CACX. No 31229557 HOXA11-AS LncRNA Homo sapiens Adrenocortical Carcinoma ACC tissues Expression[highly expressed] qRT-PCR//Microarray In these samples, 874 lncRNAs were differentially expressed in ACC compared with NAC, of which 409 were upregulated, and 465 were downregulated. The 874 differentially expressed lncRNAs corresponded to 330 annotated lncRNA genes. Among the upregulated lncRNAs, the greatest log2 fold change was 8.5 for an unannotated lncRNA gene, and RAD50 was the geratest upregulated, annotated lncRNA gene with a log2 fold change of 6.1. Among the downregulated lncRNAs, the greatest log2 fold change was 8.3 for an unannotated lncRNA gene and 6.4 for HAND2, the greatest downregulated annotated lncRNA gene; of these, 183 differently expressed lncRNAs had established functions in cancer development and cancer progression. Selected carcinogenesis-related lncRNAs are summarized in Table 2. No 31522749 HOXA11-AS LncRNA Homo sapiens lung non-small cell carcinoma tissues Interaction(miR-642b-3p and PDE4D） Microarray It was hypothesized that HOXA11-AS may have a function in NSCLC by regulating the expression of miR-642b-3p and PDE4D, which laid the foundation for the further elucidation of the potential molecular mechanisms of NSCLC. No 29616096 HOXA11-AS LncRNA Homo sapiens Subarachnoid Hemorrhage SAH patients Interaction(miR-15a and STAT3) Western Blot//Transfection//Genotyping//qRT-PCR//Luciferase Report Assay//ELISA The survival rate was remarkably higher in SAH patients carrying the AA genotype of rs17427875 when compared with those carrying the AT genotype. The expression of miR-15a was significantly repressed in the peripheral blood and CSF of SAH patients carrying the AT allele when compared with that in patients carrying the AA allele. MiR-15a showed a remarkable efficacy in inhibiting the luciferase activity of wild type lncRNA-HOXA11-AS and STAT3 in THP-1 cells.HOXA11-AS-T showed a stronger ability to suppress the expression of miR-15a and activate the expression of STAT3, TNF-α and NF-κB in THP-1 cells when compared with P-HOXA11-AS-A. The survival rate was remarkably higher in SAH patients carrying the AA genotype of rs17427875 when compared with those carrying the AT genotype. No 35700456 HOXA10-AS LncRNA Homo sapiens Leukemia, Myeloid, Acute cell lines Expression[highly expressed] Flow Cytometry Here, we show that the lncRNA HOXA10-AS, located antisense to HOXA10 and mir-196b in the HOXA cluster, is highly expressed in hematopoietic stem cells (HSCs) as well as in KMT2A-rearranged and NPM1 mutated acute myeloid leukemias (AMLs). No 31867596 HOXA10 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 HOTTIP-202 LncRNA Homo sapiens Adrenocortical Carcinoma ACC tissues Expression[highly expressed] qRT-PCR//Microarray In these samples, 874 lncRNAs were differentially expressed in ACC compared with NAC, of which 409 were upregulated, and 465 were downregulated. The 874 differentially expressed lncRNAs corresponded to 330 annotated lncRNA genes. Among the upregulated lncRNAs, the greatest log2 fold change was 8.5 for an unannotated lncRNA gene, and RAD50 was the geratest upregulated, annotated lncRNA gene with a log2 fold change of 6.1. Among the downregulated lncRNAs, the greatest log2 fold change was 8.3 for an unannotated lncRNA gene and 6.4 for HAND2, the greatest downregulated annotated lncRNA gene; of these, 183 differently expressed lncRNAs had established functions in cancer development and cancer progression. Selected carcinogenesis-related lncRNAs are summarized in Table 2. No 31522749 HOTTIP LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Regulation[miR-615-3p/HMGB3 axis ] qRT-PCR//Luciferase Report Assay//Western Blot Our data revealed that HOTTIP was upregulated and miR-615-3p was downregulated in NSCLC tissues and cells.In conclusion, our study suggested that HOTTIP might promote glycolysis under hypoxic conditions at least partly through regulating miR-615-3p/HMGB3 axis in NSCLC cells. Targeting HOTTIP might be a promising therapeutic strategy for NSCLC treatment. No 31422060 HOTTIP LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung 52 serial samples from 18 NSCLC patients Expression(highly expressed) qRT-PCR We observed that patients that relapsed after surgery displayed increased postsurgical EV HOTTIP levels in comparison with presurgical levels. In the relapsed patients with several samples available between surgery and relapse, we observed an increment in the EV HOTTIP levels when approaching to relapse, which indicated its potential utility for monitoring disease recurrence. No 34111710 HOTTIP LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Mutation Genotyping In the case–control study, we explored the association of four tagSNPs in the lncRNA HOTTIP gene with CRC risk and prognosis in a population of 1848 northern Chinese individuals. Rs3807598, rs2067087, and rs17427960 polymorphisms were newly found to be associated with CRC risk both in overall and stratified analysis. No 30940774 HOTTIP LncRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR As compared with healthy controls, HOTTIP lncRNA was over expressed in a statistically significant manner in plasma samples of patients (P=0.001). Significant relationship between HOTTIP expression and positive family history of CRC was observed, too (P=0.04). The ROC curve analysis showed an AUC value of 0.775, a specificity of 82%, a sensitivity of 76%, with a cut off value equal to 2.40 (P =0.001). No 32587834 HOTTIP LncRNA Homo sapiens Colorectal Neoplasms blood Expression[lower expressed] qRT-PCR Exosomes from healthy donors carried significantly more H19, HULC and HOTTIP transcripts in comparison to CRC patients. Correlation analysis between lncRNAs and clinical data revealed a statistical significance between low levels of exosomal HOTTIP and poor overall survival. This was confirmed by multivariate analysis that HOTTIP is an independent prognostic marker for overall survival (HR: 4.5, CI: 1.69–11.98, p = 0.0027). Here, HOTTIP poses to be a valid biomarker for patients with a CRC to predict post-surgical survival time. No 31251124 HOTTIP LncRNA Homo sapiens Colorectal Neoplasms blood Mutation[rs1859168 ] Genotyping Both rs8159168 and high HOTTIP confer increased risk for colorectal cancer development. No 32539564 HOTTIP LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cell lines interaction[miR-744-5p] qRT-PCR Long non-coding RNA (lncRNA) HOTTIP was found to be up-regulated and to act as an oncogene in PTC. Moreover, miR-744-5p expression interferes with lncRNA HOTTIP ability to promote proliferation and downregulate apoptosis in papillary thyroid carcinoma. No 32335029 HOTTIP LncRNA Homo sapiens Ovarian Neoplasms OC tissues Interaction[PD-L1] Western Blot//Flow Cytometry//RIP//Luciferase Report Assay//IHC//ChIP HOTTIP, IL-6 and PD-L1 were all highly expressed in OC tissues. A positive correlation was observed between IL-6 and PD-L1 and that between HOTTIP and IL-6 in OC tissues. HOTTIP was noted to promote the expression of IL-6 by binding to c-jun, which resulted in a promoted PD-L1 expression in neutrophils and immune escape while inhibiting T cell proliferation as well as tumor immunotherapy. No 31533774 HOTTIP LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissue Expression[highly expressed] ISH//qRT-PCR Increased HOTTIP expression was observed in all available prostate cancer tissue specimens compared with that in paired normal tissue. High HOTTIP expression was positively associated with bad clinicopathologic features, including higher pathologic T stage (p < 0.001), presence of extraprostatic extension (p < 0.001), seminal vesicle invasion (p < 0.001), perineural invasion (p < 0.001), and the tumor involvement of resection margin (p = 0.044). Also, patients with high HOTTIP expression showed poorer overall survival than those with low expression. No 31570281 HOTTIP LncRNA Homo sapiens Leukemia AML genome Regulation( CTCF chromatin boundary activity and TAD integrity) In Vivo Experiment//qRT-PCR//RNA-seq HOTTIP lncRNA is highly expressed in acute myeloid leukemia (AML) driven by MLL rearrangements or NPM1 mutations to mediate HOXA topologically associated domain (TAD) formation and drive aberrant transcription. Thus, HOTTIP-mediated R-loop formation directly reinforces CTCF chromatin boundary activity and TAD integrity to drive oncogene transcription and leukemia development. No 35180428 HOTTIP LncRNA Homo sapiens Carcinoma, Ductal, Breast Plasma Expression[highly expressed] qRT-PCR Plasma TINCR, HOTTIP, and SPRY4-IT1 upregulation and ANCR downregulation were observed in SSc patients compared with controls. No 32442909 Hotairm1-203 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 7. No 30974198 HOTAIRM1-201 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).42). No 33330027 HOTAIRM1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cancerous and paracancerous tissues of NSCLC Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR LncRNA-HOTAIRM1 showed varied expression levels in different malignant tumor cell lines. There was a significant association between the expression of HOTAIRM1 and histopathological differentiation, tumor size, tumor/node/metastasis (TNM) stage, and Ki-67 of NSCLC patients. In addition, the relative expression of HOTAIRM1 in NSCLC tissues was significantly higher when compared with the individual patients' matched paracancerous tissues. Our study indicated there was a significant association between the expression of HOTAIRM1 and histopathological differentiation, tumor size, TNM stage, and Ki-67 of NSCLC patients, but not in gender, age, histology, lymph node metastasis state, and smoking history. Moreover, patients with high expression of HOTAIRM1 have shorter OS compared to the patients with high expression of HOTAIRM1. No 31880484 HOTAIRM1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung exosomes Expression(highly expressed) Migration Assay//FISH//qRT-PCR//Luciferase Report Assay//IP//Invasion Assay//IF The expression of lnc HOTAIRM1 (HOTAIRM1) in exosomes secreted by NSCLC tissues increased. After exosomal HOTAIRM1 entered CAFs, HOTAIRM1 can adsorb miR-328-5p to up-regulate the expression of SPON2 in CAFs. Up-regulation of SPON2 in CAFs could promote the migration and invasion of NSCLC cells. No 36153414 HOTAIRM1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 HOTAIRM1 LncRNA Homo sapiens Lung Neoplasms MDSCs, peripheral blood cells Interaction( HOTAIRM1/HOXA1) Flow Cytometry//qRT-PCR In this study, we demonstrated that HOTAIRM1 was expressed in MDSCs and that overexpression of HOTAIRM1 could downregulate the expression of suppressive molecules in MDSCs. In addition, HOTAIRM1 levels were observed to be decreased in the peripheral blood cells of lung cancer patients compared with those of healthy controls. By analyzing HOTAIRM1 expression levels in different types of lung cancer, we found that HOTAIRM1 was mainly expressed in lung adenocarcinoma. Taken together, this study illustrates that HOTAIRM1/HOXA1 downregulates the immunosuppressive function of MDSCs and may be a potential therapeutic target in lung cancer. No 29662483 HOTAIRM1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Expression[lower expressed] qRT-PCR//MTT//Western Blot//Transwell Assay Our data showed that HOTAIRM1 was downregulated in CRC tissues and cell lines (HCT116 and SW480). No 31261026 HOXA11-AS LncRNA Homo sapiens Stomach Neoplasms tissues Regulation qRT-PCR//RNA-seq The results of our study demonstrated that the five-lncRNAs PART1, UCA1, DIRC3, HOTAIR, and HOXA11AS require more investigation to be confirmed as diagnostic biomarkers in gastric cancer. No 35949302 HOXA-AS2 LncRNA Homo sapiens Multiple Sclerosis blood Expression[lower expressed] qRT-PCR Relative expressions of SPRY4-IT1, HOXA-AS2, LINC-ROR, and MEG3 were significantly lower in female MS patients compared with female healthy subjects. No 32578033 HULC LncRNA Homo sapiens Sepsis blood regulation[HULC/miR-204-5p/TRPM7 network ] Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay HULC and TRPM7 were increased and accompanied with decreased miR-204-5p expression in serum of sepsis patients. LPS impaired cell viability, and promoted cell apoptosis, inflammatory response and oxidative stress in HUVECs by regulating HULC/miR-204-5p/TRPM7 axis. No 32484206 HOXA-AS2 LncRNA Homo sapiens Glioblastoma glioblastoma tissues Interaction(miR-885-5p/RBBP4 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//BrdU//Bioinformatics Analysis HOXA-AS2 and RBBP4 were found to be overexpressed in glioblastoma. . Experimental results showed that HOXA-AS2 and RBBP4 contributed to the tumorigenesis of glioblastoma cells. However, miR-885-5p was observed to be downregulated in glioblastoma. Findings also indicated that HOXA-AS2 could negatively regulate miR-885-5p, thereby enhancing RBBP4 expression. No 33430870 HULC LncRNA Homo sapiens Ewing sarcoma ewing sarcoma cells Expression[highly expressed] qRT-PCR//Luciferase Report Assay//Western Blot Herein, by performing a high-throughput screening we identify the lncRNA HULC (Highly Upregulated in Liver Cancer) as a prominent target of YK-4-279 activity in ES cells. Mechanistically, we find that HULC promotes the expression of TWIST1 oncogene by sponging miR-186. Downregulation of HULC upon treatment with YK-4-279 reduces the expression of TWIST1 by unleashing miR-186 and favoring its binding to TWIST1 transcripts. No 31639426 HULC LncRNA Homo sapiens Hepatitis B virus 100 HBV patients and 100 healthy controls Mutation(rs7763881 ) Genotyping Our results suggest that HULC rs7763881 A/C might be a biomarker for HBV susceptibility. No 34677712 HULC LncRNA Homo sapiens Digestive System Tumors 1312 patients Expression(highly expressed) Bioinformatics Analysis The up-regulated expression level of HULC was associated with poorer overall survival (OS) in patients with digestive system tumors (HR = 1.83, 95% CI: 1.05-3.19, P = 0.033). Subgroup analysis showed that cancer type (pancreatic cancer or gastric cancer), residence region (China, Japan or Korea), and specimen (serum) significantly associated between HULC and OS. In addition, high HULC expression significantly increased the risk of high TNM stage (OR = 2.51, 95%CI: 1.36-4.62, P < 0.05), poor differentiation (OR = 1.38, 95%CI: 1.02-1.87, P < 0.05) and lymphatic node metastasis (LNM, OR = 4.93, 95% CI: 3.47-6.99, P < 0.05). The up-regulated expression level of HULC was associated with poorer overall survival (OS) in patients with digestive system tumors (HR = 1.83, 95% CI: 1.05-3.19, P = 0.033). Subgroup analysis showed that cancer type (pancreatic cancer or gastric cancer), residence region (China, Japan or Korea), and specimen (serum) significantly associated between HULC and OS. In addition, high HULC expression significantly increased the risk of high TNM stage (OR = 2.51, 95%CI: 1.36-4.62, P < 0.05), poor differentiation (OR = 1.38, 95%CI: 1.02-1.87, P < 0.05) and lymphatic node metastasis (LNM, OR = 4.93, 95% CI: 3.47-6.99, P < 0.05). No 35183058 HULC LncRNA Homo sapiens Hepatocellular Carcinoma Related Chronic Virus C Infection Egyptian Patients Expression(highly expressed) qRT-PCR HULC was more highly expressed in HCC patients than in the HCV group (p = 0.018), indicating its potential use in screening and the early diagnosis of HCC. HULC was more highly expressed in HCC patients than in the HCV group (p = 0.018), indicating its potential use in screening and the early diagnosis of HCC. No 36140836 HULC LncRNA Mus musculus Non-alcoholic Fatty Liver Disease liver tissue Regulation[MAPK signaling pathway] qRT-PCR Increased expression of HULC was found in liver tissue of NAFLD rats.Collectively, this present study provides evidence that inhibition of lncRNA HULC improves hepatic fibrosis and decrease hepatocyte apoptosis in rats with NAFLD by inhibiting the MAPK signaling pathway. No 30908654 HULC LncRNA Mus musculus Myocardial Reperfusion myocardial tissue regulation[NLRP3/Caspase-1/IL-1β signaling pathway] qRT-PCR//MTT//IHC//Western Blot We found that HULC was downregulated and miR-377-5p was upregulated in IR-injured myocardial tissue and the H/R-induced H9c2 cell. Overall, these results indicate that the protective effect of HULC against myocardial I/R injury and H/R cardiomyocyte apoptosis partially relies on the inhibition of NLRP3/Caspase‑1/IL‑1β signaling pathway. No 32674625 HTT CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 HTATSF1P2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 HSPD1P11 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 619 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 HSP90B2P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 HSP90B1-204 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 HSD3BP4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 HSD17B7P2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 HSD11B1-AS1 LncRNA Homo sapiens Mucocutaneous Lymph Node Syndrome 50 patients with KD (median age, 19 months; 29 males and 21 females) Expression(highly expressed) qRT-PCR Among these genes, G0/G1 switch gene 2 (G0S2) and its antisense lncRNA, HSD11B1-AS1, were upregulated during the acute phase of KD (P < 0.0001 and <0.0001, respectively). No 35292727 hsa_cir_0091074 CircRNA Homo sapiens Acute Coronary Syndrome blood Expression[lower expressed] Microarray The data were log2-transformed and median centred by gene using the Adjust Data function in CLUSTER 3.0 software and then further analysed with hierarchical clustering with average linkage criterion (Tables ?(Tables22 and ?and55). No 32419790 HOXD-AS2 LncRNA Homo sapiens Glioblastoma gliomas tissues and cells Interaction( miR-661) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay We have previously reported that lncRNA HOXD-AS2, which is specifically up-regulated in gliomas, can activate cell cycle and promote the development of gliomas.We found that TFE3 acted as a transcription factor binding to the HOXD-AS2 promoter region and raised H3K27ac to activate HOXD-AS2. As the cytoplasmic-located lncRNA, HOXD-AS2 could be degraded by miR-661. No 35269968 HOXD10 LncRNA Homo sapiens Glioblastoma samples from patients Expression(lower expressed) IHC The mRNA expression of HOXD10 was up-regulated in GBM according to GEPIA, while the protein expression of HOXD10 in GBM was down-regulated according to IHC analysis of samples from patients collected from our hospital. Univariate analysis revealed that low HOXD10 expression, complete surgical resection, postoperative radiotherapy, postoperative temozolomide chemotherapy and IDH1 mutation were all beneficial prognostic factors. No 34737577 HOXC13-AS LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 HOXC10 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC and para-carcinoma tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//Microarray The qRT-PCR assay showed the Expression[Expression[up-expression]-expression]regulation of miR-455-5p, miR-21-3p, miR-96-5p, miR-93-5p, RP11-973H7.5, and HOXC10 expression in LSCC as well as the Expression[down-expression]regulation of miR-486-5p, LINC00657, CTC-297N7.9, hsa_circ_0008832, hsa_circ_0033988, hsa_circ_0001445, hsa_circ_0007013, KRT4, HOPX, TGFBR2, and KDR expression in LSCC (Fig. 7). No 30128795 HOXB-AS3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck TCGA Regulation qRT-PCR Then, we recognized a set of six FElncRNAs PFLS (SLCO4A1-AS1, C1RL-AS1, PCED1B-AS1, HOXB-AS3, MIR9-3HG, and SFTA1P) for predicting patients' prognostic risks and survival outcomes. Notably, the low-risk group of the PFLS showed a higher MHC score and cytolytic activity (CYT) score than the high-risk group, implying the low-risk group may have greater tumor surveillance and killing ability.  No 34976018 HOXB-AS3 LncRNA Homo sapiens Sarcoma, Myeloid Regulated[up-regulated] BrdU//Microarray Mechanistically, HOXB-AS3 potentiated the expressions of several key factors in cell cycle progression and DNA replication without affecting the expressions of HOX genes. In AML, patients with higher HOXB-AS3 expression had shorter survival than those with lower HOXB-AS3 expression (median overall survival (OS), 17.7 months versus not reached, P < 0.0001; median relapse-free survival, 12.9 months versus not reached, P = 0.0070). In AML, patients with higher HOXB-AS3 expression had shorter survival than those with lower HOXB-AS3 expression (median overall survival (OS), 17.7 months versus not reached, P < 0.0001; median relapse-free survival, 12.9 months versus not reached, P = 0.0070). In MDS, patients with higher HOXB-AS3 expression also had adverse prognosis compared with those with lower HOXB-AS3 expression (median OS, 14.6 months versus 42.4 months, P = 0.0018). The prognostic significance of HOXB-AS3 expression was validated in the TCGA AML cohort and another MDS cohort from our institute. No 31234830 HOXB-AS1 LncRNA Homo sapiens Breast Neoplasms TCGA and breast cancer cells Expression [lower expressed] qRT-PCR The qRT-PCR identified 5 lncRNAs with significantly differential expression in breast cancer cells based on the 9 lncRNAs of the prognostic model, and the results were consistent with the tissues. No 33614483 Hoxb3os LncRNA Mus musculus Polycystic Kidney Diseases cyst epithelium of mutant mice Regulation [ ADPKD and regulates mTOR signaling ] ISH//qRT-PCR//RNA-seq//Western Blot Hoxb3os was highly expressed in renal tubules in adult WT mice, whereas its expression was lost in the cyst epithelium of mutant mice. Deletion of Hoxb3os resulted in increased phosphorylation of mTOR and its downstream targets, including p70 S6 kinase, ribosomal protein S6, and the translation repressor 4E-BP1. Consistent with activation of mTORC1 signaling, Hoxb3os mutant cells displayed increased mitochondrial respiration. The Hoxb3os mutant phenotype was partially rescued upon re-expression of Hoxb3os in knockout cells. No 29716997 HOXA-AS2 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 HOXA-AS2 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[highly expressed] qRT-PCR The HOXA-AS2 expression was significantly elevated in cancerous tissues as compared to marginal noncancerous tissues in gastric cancer patients (p < 0.0001). Analysis of gene expression data revealed that there was a significant association between an increased HOXA-AS2 gene expression and clinicopathological features such as tumor size ? 5 cm (p = 0.009), lymph node metastasis (p = 0.028), and H. pylori infection (p = 0.011). No 33174119 HOXA-AS2 LncRNA Homo sapiens Stomach Neoplasms gastric cancer samples Expression(lower expressed) RNA-seq Expression levels of LINC-ROR, HOXA-AS2 and MEG3 lncRNAs have been lower in gastric cancer samples compared with nearby non-cancerous samples (Expression ratios = 0.26, 0.37 and 0.36; P values = 0.021, 0.015 and 0.032, respectively). Expressions of LINC-ROR and HOXA-AS2 were not associated with any clinical or pathological parameter. ROC curve analysis revealed that HOXA-AS2 and LINC-ROR could significantly differentiate between gastric cancer samples and nearby non-cancerous tissues (AUC values = 0.68 and 0.64; P values = 0.01 and 0.04, respectively). No 36299522 HOXA-AS2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] Wound Healing Assay//qRT-PCR//MTT//RNA-seq//Colony Formation Assay Consistently, lncRNA HOXA-AS2 expression was significantly upregulated in HCC and its higher expression positively correlated with poor prognosis and stem cell-related functions. Consistently, lncRNA HOXA-AS2 expression was significantly upregulated in HCC and its higher expression positively correlated with poor prognosis and stem cell-related functions. No 33149607 ITFG2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ITGA5 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and CRC cell lines regulation[miR-107,FOXJ3 ] Western Blot//qPCR//Flow Cytometry//PCR//IF The expression of ITGA5 circRNA was significantly reduced in CRC tissues and CRC cell lines.ITGA5 circRNA may act as a sponge for miR-107 to upregulate FOXJ3 expression and act as a tumor suppressor in CRC cells. No 32305992 LINC00460 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues and cells Regulation[up-regulating microRNA-206 ] RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//IF LINC00460 and STC2 were highly expressed while miR-206 was poorly expressed in HNSCC. Besides, miR-206 was found to bind to both LINC00460 and STC2. No 31075234 LINC00221 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and serum samples Expression(highly expressed) Other LINC00221 was upregulated in HCC tissues and serum samples. Survival analysis and receiver operating characteristic curve further revealed its prognostic and diagnostic roles. No 33406920 LINC00184 LncRNA Homo sapiens Stomach Neoplasms GC cells Interaction(miR-145/ANGPT2 pathway ) Western Blot//Invasion Assay//CCK8//qRT-PCR//IF//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay Our findings indicate that the LINC00184/miR-145/ANGPT2 pathway has a crucial function in the development of GC and can act as a possible biomarker and targets for GC therapy. No 33758610 LINC00184 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Expression[highly expressed] qRT-PCR qPCR results indicated marked upregulation of CDKN2A-AS1, C7orf55, LINC00184, HEIH, and ZEB2 expression, whereas that of SNHG3, LINC00630, LOC100133669, APTR, LINC-PINT, and SEMA5A was downregulated in OC tissues as compared with levels in normal ovary tissues (Fig. ?(Fig.5b5b). No 31098301 LINC00173 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung serum Expression[highly expressed] qRT-PCR The qRT-PCR analysis showed that the serum LINC00173 expression level in 108 NSCLC patients was higher than that in 91 healthy donors and 55 patients with benign pulmonary disease (BPD). No 32623390 LINC00173 LncRNA Homo sapiens Melanoma melanoma specimens Expression(highly expressed) qRT-PCR The expression level of LINC00173 in melanoma specimens was distinctly higher than that in adjacent non-neoplasm specimens (p<0.01). Multivariate assays confirmed that LINC00173 expression level was an independent prognostic predictor of melanoma patients (p<0.05). Besides, LINC00173 was expressed more frequently in patients with advanced melanoma than in patients with early melanoma. No 35239877 LINC00092 LncRNA Homo sapiens Colonic Neoplasms COAD tissues Expression[lower expressed] qRT-PCR "To manifest the expression of integrated analysis, we selected the previously obtained eight biomarkers including XXbac‐ B476C20.9, PP7080, CDKN2B‐AS1, LINC00092, CA3‐AS1, HAND2‐AS1, CTD‐2269F5.1, and LINC01082. In Figure 8, these eight selected DElncRNAs for qRT‐PCR confirmation were eight optimal diagnostic lncRNA biomarkers, and these eight DElncRNAs were all downregulated in the high‐ throughput transcriptome datasets for COAD compared with normal controls. The expression of these selected eight genes in qRT‐PCR was consistent with our integrated analysis." No 30269368 LIN7A LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LIMS3-LOC440895 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LIMD2 LncRNA Homo sapiens Esophageal Neoplasms ECA tissues Expression(highly expressed) Bioinformatics Analysis Moreover, quantitative reverse-transcription polymerase chain reaction (qRT-PCR) revealed significant upregulation of LIMD2 expression in ECA tissues. ECA may be closely correlated with NF-κB and PI3K/Akt signaling. No 34868263 LIMCH1-220 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LILRB3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LILRB2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LILRA6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LIFR-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR In this study, levels of LIFR-AS1 were significantly higher in GC tumor samples relative to adjacent normal tissue samples. In addition, elevated LIFR-AS1 expression was positively correlated with more advanced and aggressive GC features, such as larger tumor size, lymphatic metastasis, and more advanced TNM stage. Survival analyses revealed that elevated LIFR-AS1 expression was correlated with worse overall survival and disease-free survival. Multivariate analysis further confirmed the relevance of LIFR-AS1 as an independent predictor of GC patient outcomes. No 32495872 LIFR-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LIAS-217 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LHFPL3-AS2 LncRNA Homo sapiens Adenocarcinoma of Lung ADC samples Interaction(miR-127-5p and miR-424-5p) Microarray With microarray gene expression analysis, we found that only lncRNAs-PCAT6 was commonly upregulated among four datasets, and four lncRNAs (LINC00968, PGM5-AS1, LHFPL3-AS2 and SFTA1P) were significantly downregulated in the ADC samples as compared to the normal tissues. Meanwhile, for LHFPL3-AS2, high-risk patients showed better overall survival (HR=0.6 or 0.62; P < .0001 or P = 0.0014), overall survival from TCGA datasets (HR=0.72; P = 0.015) and recurrence-free survival (HR=0.72; P = 0.015). Then, LHFPL3-AS2 was predicted to bind to two miRNAs, miR-127-5p and miR-424-5p. Finally, validation and functional enrichment analysis of the downstream key mRNAs showed significant enrichment in some cancer-related pathways, such as cell adhesion in cancer and small cell lung cancer. Meanwhile, for LHFPL3-AS2, high-risk patients showed better overall survival (HR=0.6 or 0.62; P < .0001 or P = 0.0014), overall survival from TCGA datasets (HR=0.72; P = 0.015) and recurrence-free survival (HR=0.72; P = 0.015). No 35435361 LHFPL3-AS1 LncRNA Homo sapiens Melanoma cell lines regulation[miR-181a-5p/BCL2 pathway] RNA Pull-Down//CLIP//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay In patients with melanoma, the expressions of PTBP1 and LHFPL3-AS1 were significantly upregulated compared with the healthy donors. In this study, our findings revealed that the lncRNA LHFPL3-AS1-long, generated from the polypyrimidine tract binding protein 1 (PTBP1)-mediated splicing of the LHFPL3-AS1 precursor, upregulated BCL2 protein to contribute to tumorigenesis of melanoma stem cells. The in vitro and in vivo results showed that LHFPL3-AS1-long directly interacted with miR-181a-5p to inhibit the mRNA degradation of Bcl-2 (the target of miR-181), thus suppressing apoptosis of melanoma stem cells. No 33149126 LGALS17A LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 829 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LET LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 LEMD1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LEMD1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 LEF1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Expression[highly expressed] qRT-PCR We showed that LEF1-AS1 was distinctly upregulated in ESCC tissues compared with the matched normal tissues (p < 0.01). Higher levels of LEF1-AS1 were associated with lymph nodes metastasis (p = 0.009) and clinical stage (p = 0.008). Clinical investigation revealed that ESCC patients with high LEF1-AS1 level showed a significant shorter 5-year OS (p = 0.0028) and DFS (p = 0.0025). No 31599448 LEF1-AS1 LncRNA Homo sapiens Leukemia, Lymphocytic, Chronic, B-Cell The human CLL primary cells and cell lines (MEC1 and JVM3) Interaction(LEF1) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//EdU Staining By quantitative real-time polymerase chain reaction (qRT-PCR), we validated that primary CLL cells harbor higher lncRNA LEF1-AS1 levels than normal B cells. RNA Binding Protein Immunoprecipitation and RNA pull-down demonstrated that LncRNA LEF1-AS1 and LEF1 protein could combine especially. No 34563944 Leat1 LncRNA Mus musculus Defective Anorectal And Urogenital Malformations genital tubercle Expression[lower expressed] qRT-PCR We show that a loss of Leat1 leads to reduced EfnB2 expression in the developing female genital tubercle, reduced anogenital distance and decreased fertility. No 31830612 LDHA-211 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 LDB2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LCP2-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 LCP2-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 LCN1P1 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[lower expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 18 No 32547537 LINC00210 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells Expression[highly expressed] qRT-PCR LINC00210 and GFRA1 were up-regulated, and miR-342-3p was down-regulated in osteosarcoma tissues and cells. No 32841458 LINC00260 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 881 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LBX2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00261 LncRNA Homo sapiens Gallbladder Neoplasms GBC tissues,cell lines Expression[lower expressed] qRT-PCR The expression level of Linc00261 in GBC was significantly lower than normal tissues' and it was also up-regulated after surgery. The Linc00261 expression was significantly correlated with large tumor size (P<0.0001), late TNM stage (P=0.008), negative liver metastasis (P=0.027) and well differentiated phenotype (P=0.017). The patients with lower Linc00261 expression had significantly worse outcomes in terms of overall survival (P=0.0188) and progression-free survival (P=0.0029), and the low expression of Linc00261 was identified as an independent risk factor affecting postoperative survival rate of the patients (P<0.01). The expression of Linc00261 in serum was down-regulated of GBC patients and increased in the patients after operation. Linc00261 expressed in serum was also positively associated with its expression in GBC tissue of patients (P<0.0001). The GBC diagnosis efficacy of using the serum Linc00261 level to identify the GBC has high specificity and sensitivity (AUC 0.805). No 35117219 LINC0042646 LncRNA Homo sapiens Lung Neoplasms lung tissue Expression[highly expressed] qRT-PCR LINC0042646 expression level was elevated in 46 cases in normal lung tissue compared to the tumor tissue of the 72 NSCLC patients. LINC0042646 expression level was significantly correlated with the clinical stage (P < 0.05). No 31691516 LINC00426-202 LncRNA Homo sapiens Diabetes Mellitus, Type 2 five patients with T2D and paired controls (lower expressed) qRT-PCR//Bioinformatics Analysis//Microarray The top five upregulated lncRNAs are ENST00000381108.3, ENST00000515544.1, ENST00000539543.1, ENST00000508174.1, and ENST00000564527.1, and the top five downregulated lncRNAs are TCONS_00017539, ENST00000430816.1, ENST00000533203.1, ENST00000609522.1, and ENST00000417079.1. No 35257412 LINC00426 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[lower expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 LINC00402 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00373-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC00365 LncRNA Homo sapiens Stomach Neoplasms eighty-three GC tissues Expression(lower expressed) qRT-PCR The significant downregulation of LINC00365 (66.3%) and RP11-354K4.2 (62.7%) were observed in GC samples; while the upregulation of LINC01389, RP11-138J23.1, TWIST1, MMP13, MAML1, CD44s, and SALL4 were found in 67.5%, 45.8%, 56.6%, 44.6%, 59%, 55.4%, and 62.7% tumors samples at the mRNA level, respectively. No 36208698 LINC00355 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00355 LncRNA Homo sapiens Urinary Bladder Neoplasms urinary exosomes Expression[highly expressed] qRT-PCR LINC00355, UCA1-203, and MALAT1 expression was significantly higher in TCC patients compared to controls (non-malignant or normal samples). However, UCA1-201 expression was significantly decreased in TCC patients compared with controls. No 30568497 LINC00355 LncRNA Homo sapiens Breast Neoplasms BC and MCF7 long-term estrogen deprived cell lines Interaction(MENIN/ p27Kip) RNA Pull-Down//Western Blot//qRT-PCR//RIP//RNA-seq//Cell Proliferation Assay//ChIP Decreasing expression of the most up-regulated lncRNA, LINC00355, in BC and MCF7 long-term estrogen deprived cell lines decreases cellular invasion and proliferation. Subsequent mechanistic studies show that LINC00355 binds to MENIN and changes occupancy at the CDKN1B promoter to decrease p27Kip. In summary, this is a key study discovering lncRNAs in LSR BC and LINC00355 association with epigenetic regulation and proliferation in BC. No 35418131 LINC00351 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00342 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00342 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[lower expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 LINC00336 LncRNA Homo sapiens Lung Neoplasms lung cancer tissues,cell lines Expression[highly expressed] qRT-PCR Here we demonstrate that a nuclear lncRNA LINC00336 is upregulated in lung cancer and functions as an oncogene by acting as a competing endogenous RNA (ceRNAs). No 30787392 LINC00324 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC patients Expression(highly expressed) qRT-PCR Among dysregulated lncRNAs, we observed LINC00324 significantly upregulated (2.11-fold; p-value = 0.0032) and LOC100507053 significantly downregulated (2.22-fold; p-value = 0.0001) in ESCC patients. No 35237522 LINC00324 LncRNA Homo sapiens Intervertebral Disc Degeneration IDD patients Expression(highly expressed) qRT-PCR//Transfection//Western Blot LINC00324 and FasL were upregulated in IDD patients, and they were positively correlated. No 33511550 LINC00320 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00320 LncRNA Homo sapiens Glioma glioma tissues Regulation[Wnt/β-catenin signaling] RNA Pull-Down//Northern Blot//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay In current study, we found a HMGB1 regulated lncRNA, Linc00320, is significantly decreased in Glioma malignant tissues and its low expression predicts poor prognosis. In addition, we found that Linc00320 binds to β-catenin and inhibits the activity of Wnt/β-catenin signaling by disrupting β-catenin binds to TCF4 in Glioma cells. No 30503496 LINC00313 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC serum, tissue and cell lines Interaction(miR-4429) qRT-PCR The expression of LINC00313 was significantly up-regulated while the expression of miR-4429 was down-regulated in NSCLC serum, tissue and cell lines. A negative correlation was found between LINC00313 and miR-4429 in patients with NSCLC. ROC curves showed that LINC00313 and miR-4429 had high diagnostic value and Kaplan-Meier curve results showed that high expression of LINC00313 and low expression of miR-4429 predicted poor prognosis. ROC curves showed that LINC00313 and miR-4429 had high diagnostic value and Kaplan-Meier curve results showed that high expression of LINC00313 and low expression of miR-4429 predicted poor prognosis. No 35485050 Linc00312 LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Mutation( rs12497104 ) qRT-PCR//Luciferase Report Assay//Genotyping We demonstrated that rs12497104 (G > A) GA genotype carriers had a higher risk than others for suffering from NPC (GA vs GG, OR = 1.437, P = 0.003). Besides, patients with rs12497104 AA genotype showed a poorer overall survival in contrast to GG genotype (AA vs GG, HR = 2.117, P = 0.011). In addition, the heterozygous carriers of rs15734 (G > A) and rs164966 (A > G) were correlated with decreased risk of NPC (GA vs GG, OR = 0.778, P = 0.031; GA vs AA, OR = 0.781, P = 0.033, respectively). We found that the three SNPs might influence the expression of linc00312 in a genotype specific feature. The local centroid secondary structure as well as the minimum free energy of linc00312 were changed following the candidate SNPs alterations. Besides, we revealed that the G to A alteration at rs12497104 disrupted the binding between mir-411-3p and linc00312. We demonstrated that rs12497104 (G > A) GA genotype carriers had a higher risk than others for suffering from NPC (GA vs GG, OR = 1.437, P = 0.003). Besides, patients with rs12497104 AA genotype showed a poorer overall survival in contrast to GG genotype (AA vs GG, HR = 2.117, P = 0.011). In addition, the heterozygous carriers of rs15734 (G > A) and rs164966 (A > G) were correlated with decreased risk of NPC (GA vs GG, OR = 0.778, P = 0.031; GA vs AA, OR = 0.781, P = 0.033, respectively). No 34336850 LINC00311 LncRNA Homo sapiens Spondylitis, Ankylosing blood Expression[highly expressed] qRT-PCR In the present study we found that LINC00311 was upregulated in AS patients comparing to healthy controls, and upregulation of LINC00311 distinguished AS patients from healthy controls. LINC00311 expression levels were positively correlated with disease activity. Comparing to pre-treatment levels, LINC00311 expression level decreased significantly after treatment. During 2-year follow-up, patients with high levels of LINC00311 showed a significantly higher rate of rehospitalization. No 31170957 LINC00309 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] qRT-PCR LINC00309 high expression was an independent predictor for worse disease-free survival (HR = 2.127; 95% CI 1.074-4.212; p = 0.030) and associated with a shorter disease-free survival (p = 0.027), especially in hormone-positive breast cancer patients (p = 0.001). LINC00309 high expression was an independent predictor for worse disease-free survival (HR = 2.127; 95% CI 1.074-4.212; p = 0.030) and associated with a shorter disease-free survival (p = 0.027), especially in hormone-positive breast cancer patients (p = 0.001). Also LINC00309 high expression was associated with a shorter disease-free survival both in selective estrogen receptor modulator related hormone therapy (p = 0.025) and aromatase inhibitors related hormone therapy (p = 0.048). Moreover, LINC00309 was an independent predictor of worse disease-free survival in hormone-receptor positive breast cancer patients on univariate (HR = 4.505; 95% CI 1.722-11.785; p = 0.002) and multivariate (HR = 4.159; 95% CI 1.537-11.251; p = 0.005) analyses. No 31406486 LINC00304 LncRNA Homo sapiens Arthritis, Rheumatoid peripheral blood mononuclear cells Expression[lower expressed] qRT-PCR//RNA-seq In the present study, 231 upregulated and 110 downregulated lncRNAs were identified as differentially expressed in patients with RA compared with the controls. Information on the top 6 up- or downregulated lncRNAs is provided in Table III. No 33456537 LINC00266-1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00265 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC00265 LncRNA Homo sapiens Leukemia, Myeloid, Acute plasma exosomal Expression(lower expressed) qRT-PCR Subsequently, the downregulated plasma exosomal lncRNAs (LINC00265, LINC00467, and UCA1) and the upregulated plasma exosomal lncRNA (SNHG1) were identified in AML patients (n=65) compared to HD (n=20). No 36276083 LINC00261 LncRNA Homo sapiens Lung Neoplasms Expression[lower expressed] qRT-PCR//Migration Assay By large-scale data mining, we identified LINC00261 as a lncRNA which was significantly downregulated in lung cancer. Low expression of LINC00261 was associated with recurrence and poor patient survival in lung adenocarcinoma. No 30597925 LINC00261 LncRNA Homo sapiens Colonic Neoplasms Expression[lower expressed] ISH//Microarray Analysis of gene microarray GSE33113 data by SAM found 65 differentially expressed lncRNA in colon cancer, including 6 Expression[up-expression]-regulated lncRNA (fold change > 2) and 59 down-regulated lncRNA (fold change < 0.05). The results of in situ hybridization showed that the negative rates of LINC00261 in colon carcinoma tissues and their adjacent non-cancerous tissues were 63.77% (88/138) and 8.70% (12/115), respectively, with a significant difference between them (p < 0.01). There was decreased expression of LINC00261 in colon cancer tissues, which was related to clinical stages, lymph node metastasis, and recurrence-free survival time of colon cancer The results of in situ hybridization showed that the negative rates of LINC00261 in colon carcinoma tissues and their adjacent non-cancerous tissues were 63.77% (88/138) and 8.70% (12/115), respectively, with a significant difference between them (p < 0.01). LINC00261 was significantly correlated with the clinical staging of patients with colon cancer (p < 0.05). Lowered expression of LINC00261 was identified as an independent risk factor affecting postoperative recurrence-free survival time of the colon cancer patients (p < 0.001). No 31850713 LINC00261 LncRNA Homo sapiens Carcinoma, Hepatocellular 22 immune cells Interaction(MiR105-5p/SELL axis ) qRT-PCR Our findings could provide insights into the selection of novel LINC00261/MiR105-5p/SELL pathway which is associated with overall survival and may impact on efficacy of immunotherapy in HCC. No 35702258 LCAL6 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC PDX models Regulation IHC Comparative analysis indicated these established PDX models of NSCLC closely resembled the original tumors with regard to NSCLC subtype-specific markers TTF-1, napsin A, p63 and expression of LCAL6 and TUG1. The tumor volume and weight were significantly reduced in the TUG1-silenced group as compared to the control group (p<0.05). However, no significant tumor growth inhibition was found in the LCAL6-silenced group (p>0.05). Expression of both TUG1and LCAL6 was reduced by siRNA treatment. Expression of Ki67 and HOXB7 was significantly suppressed in both the TUG1- and LCAL6-silenced groups compared to the control group (p<0.01). The TUG1-silenced group showed more reduced Ki67 expression than the LCAL6-silenced group (p<0.05). No 29277771 LBX2-AS1 LncRNA Homo sapiens Glioma glioma samples and cell lines Interaction(miR-491-5p/LIF axis) In Vivo Experiment//ChIP//Western Blot//Transfection//qRT-PCR//FISH//RIP//IF//Luciferase Report Assay//Cell Proliferation Assay//IHC//Bioinformatics Analysis//Transwell Assay LBX2-AS1 was upregulated in glioma samples and cell lines, and its transcription was promoted by binding to the transcription factor SP1. As a lncRNA mainly distributed in the cytoplasm, LBX2-AS1 sponge miR-491-5p to further upregulate LIF. The subsequent activated LIF/STAT3 signaling was responsible for promoting proliferation and EMT in glioma. No 34729101 ITGB1BP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KCNQ1OT1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Expression [highly expressed] Bioinformatics Analysis The lncRNA KCNQ1OT1 was found to be significantly upregulated in colorectal cancer tissues and associated with the survival of patients. No 34630508 KCNQ1OT1 LncRNA Homo sapiens Triple Negative Breast Neoplasms tumor tissues Regulation(up regulation) qRT-PCR//ChIP//Western Blot The results revealed that YY1 and lncRNA Kcnq1ot1 were upregulated in TNBC tissues, and high expression of YY1 and lncRNA Kcnq1ot1 was associated with poor patient survival. high expression of YY1 and lncRNA Kcnq1ot1 was associated with poor patient survival. No 33323961 KCNQ1OT1 LncRNA Homo sapiens Prostatic Neoplasms PC tissues regulation[up-regulating PD-L1] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//IHC//Transwell Assay KCNQ1OT1, PD-L1 and CD8 were increased, while miR-15a was decreased in PC tissues. LncRNA KCNQ1OT1 sponges miR-15a to promote immune evasion and malignant progression of PC via up-regulating PD-L1. No 32821247 KCNQ1OT1 LncRNA Homo sapiens Multiple Sclerosis Th17 cells Expression(highly expressed) qRT-PCR The results showed an increase in the expression of NEAT1, KCNQ1OT1 and RORC and a decrease in the expression of FOXP3. In plasma, an upregulation of IL17 and a downregulation of TGFB inflammatory cytokines were detected. The dysregulated expression of these genes could be attributed to relapsing-remitting MS (RR-MS) patients and help us understand MS pathogenesis better. No 35266286 KCNQ1OT1 LncRNA Homo sapiens Coronary Artery Disease blood Expression[highly expressed] qRT-PCR We found that the levels of lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1), hypoxia-inducible factor 1 alpha-antisense RNA 2 (HIF1A-AS2) and apolipoprotein A-1 antisense RNA (APOA1-AS) were significantly increased in CAD patients (KCNQ1OT1 increased by 2.38-fold, P = 0.00042; HIF1A-AS2 increased by 2.00-fold, P = 0.0001; APOA1-AS increased by 4.52-fold, P = 0.000048). No 30941792 KCNQ1OT1 LncRNA Homo sapiens Diabetic Nephropathies T2D group Regulation(MEK-5 and ERK2) IF//qPCR//H&E Staining//Western Blot The relative expression of LncRNA KCNQ1OT1, MEK-5 and ERK2 in the control group was lower than that of the T2D group and DN group (P<0.05), and the relative expression of LncRNA KCNQ1OT1 in T2D group was lower than that of DN group (P<0.05). The expression of LncRNA KCNQ1OT1 was positively-correlated with MEK-5 and ERK2 (P<0.05). The relative expression of LncRNA KCNQ1OT1, MEK-5, and ERK2 in renal tissues of the DN group was higher than those in the control group and diabetes group (P<0.05). No 35422925 KCNQ1OT1 LncRNA Homo sapiens Sepsis patients with sepsis Expression(lower expressed) qRT-PCR//ELISA Lnc-KCNQ1OT1 decreased in patients with sepsis than in HCs (p < 0.001). In sepsis patients, lnc-KCNQ1OT1 was negatively correlated with sequential organ failure assessment (SOFA) scores (r = -0.344, p < 0.001) and several SOFA subscale scores (including respiratory system, coagulation, liver, and renal systems) (all r < 0, p < 0.05). No 34761437 KCNQ1OT1 LncRNA Homo sapiens Neuroblastoma Regulation[miR-296-5p/Bax axis] Flow Cytometry//qRT-PCR//RNA Pull-Down//Western Blot Mechanistically, miR-296-5p directly bound the 3'UTR of Bax mRNA, thus repressing Bax at the mRNA and protein level. Moreover, through bioinformatic analysis and molecular experiments, we showed that KCNQ1OT1 sponged miR-296-5p and impaired its effect on NB cell apoptosis. In summary, KCNQ1OT1 is a potent promoting factor of cell apoptosis, which acts by sponging miR-296-5p and upregulating Bax. No 31433907 KCNQ1OT1 LncRNA Homo sapiens Diabetic Retinopathy retinal endothelial cells Interaction[ sponge miR-1470 ] qRT-PCR//Luciferase Report Assay In this study, regarding quantitative reverse transcription polymerase chain reaction assay, KCNQ1OT1 level was upregulated while microRNA-1470 (miR-1470) was decreased in DR patients and human retinal endothelial cells.The results suggested that KCNQ1OT1 could sponge miR-1470 and further regulate EGFR in DR. No 30784065 KCNQ1OT1 LncRNA Homo sapiens Coronary Disease CHD patients Expression(highly expressed) qRT-PCR//ELISA LncRNA KCNQ1OT1 was highest in CHD patients, followed by DCs, and lowest in HCs (p < 0.001). No 36458365 KCNQ1OT1 LncRNA Homo sapiens Aging human lung fibroblast IMR-90 cells Interaction(miR-760) qRT-PCR//Transfection//Immunoblotting Additionally, KCNQ1OT1 was downregulated during replicative senescence, and its silencing induced senescence in human lung fibroblast IMR-90 cells. Additionally, an miR-760 mimic suppressed KCNQ1OT1-mediated CK2α upregulation, indicating that KCNQ1OT1 upregulated CK2α by sponging miR-760. No 35163809 KCNQ1DN LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)108) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 KCNQ11-IT83 LncRNA Homo sapiens Arthritis, Rheumatoid keen synovial tissues Expression[highly expressed] qRT-PCR Results of RT-qPCR showed that the levels of lncRNAs MTCO2P12, KCNQ5-IT1 and RP11-83J16.1 were increased, whereas lncRNAs LINC00570, RP11-342M1.6, and REXO1L5P were decreased in RA patients compared to controls. No 32355550 KCNMB2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KCNIP4-IT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KCNIP2-AS1-201 LncRNA Homo sapiens Mouth Neoplasms oral cancer tissues Expression[lower expressed] qRT-PCR LncRNAs were aberrantly expressed in oral cancer tissues. The expression levels of ENST00000470447.1 and ENST00000412353.1 in oral cancer tissues were significantly lower than those in matched adjacent noncancerous tissues (P < .002). No 30969450 KCND3-IT1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 624 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 KCNA2-AS LncRNA Mus musculus Neuralgia, Postherpetic spinal cord tissue regulation[reducing the translocation of pSTAT3 cytoplasm] qRT-PCR//RNA Pull-Down//RIP//FISH KCNA2-AS was highly expressed in the spinal cord tissue of PHN model rats, and was positively correlated with GFAP expression. Down-regulation of KCNA2-AS alleviates PHN partly by reducing the translocation of pSTAT3 cytoplasm to the nucleus and then inhibiting the activation of spinal astrocytes. No 33225882 KC6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KATNBL1P6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KAT7 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue regulation[miR-10a] CCK8//qRT-PCR The results showed that KAT7 was downregulated in NSCLC and predicted poor survival. In conclusion, KAT7 negatively regulates miR-10a through epigenetic mechanisms to participate in NSCLC cell proliferation. The results showed that KAT7 was downregulated in NSCLC and predicted poor survival. No 32423237 JUN LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-12A) Expression[highly expressed] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD6 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 JPX LncRNA Homo sapiens Colorectal Neoplasms CRC samples Expression(highly expressed) qRT-PCR Upregulated JPX and HAR1B lncRNAs may contribute to colorectal cancer pathobiology by affecting multiple cancer-related signaling pathways. No 35526243 JPX LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[JPX/miR-145-5p/CCND2] Western Blot//ISH//Flow Cytometry//qRT-PCR//RIP//migration assay//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay Here, through integrating clinical data and a series of functional experiments, we found that lncRNA JPX expression is significantly upregulated in NSCLC tissues compared with that in paired adjacent normal tissues from two independent datasets and significantly associated with a poor survival and other malignant phenotypes (tumor stage, tumor volume) of NSCLC. These findings reveal the mechanism of X-chromosome lncRNA JPX and its core regulatory circuitry JPX/miR-145-5p/CCND2 in the development and progression of NSCLC, which bring us closer to an understanding of the molecular drivers of NSCLC. No 31253987 JPT2-213 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 JMJD1C-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ITSN1-2 LncRNA Homo sapiens Sepsis Blood Expression[highly expressed] ELISA lncRNA ITSN1-2 was highly expressed in sepsis patients compared to healthy controls and could differentiate sepsis patients from healthy controls with area under the curve (AUC) 0.777 (95% CI: 0.740-0.813). No 30803045 ITGB2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KCNQ1OT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and para-cancer tissues Expression[highly expressed] qRT-PCR "The results showed that the expression of lncRNA KCNQ1OT1 in the NSCLC tissues was 7.413 ±0.570, which was significantly higher than that of para-cancer tissues (1.302 ± 0.128) (p<0.001)" Meanwhile, the lncRNA KCNQ1OT1 expression was correlated with tumor size, tumor node metastasis (TNM) staging, and lymph node metastasis of NSCLC patients. Both univariate analysis and multivariate analysis indicated that the high expression of lncRNA KCNQ1OT1 was closely related to TNM staging and lymph node metastasis. In addition, the Kaplan-Meier analysis showed that the overall survival and progression-free survival time of patients with higher lncRNA KCNQ1OT1 expression were significantly worse than those with lower lncRNA KCNQ1OT1 expression. No 31486494 LASP1-AS LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[upregulating LASP1] qRT-PCR We found lncRNA LIM and SH3 protein 1 antisense (LASP1-AS) and its sense-cognate gene LIM and SH3 protein 1 (LASP1) were upregulated in HCC and both are correlated with poorer prognosis and lower survival of HCC patients. Meanwhile, the expression of LASP1-AS correlated positively with LASP1 expression in HCC tissues. LASP1-AS promoted the proliferation, migration, and invasion abilities of HCC in vitro and vivo by enhancing LASP1 expression. We found lncRNA LIM and SH3 protein 1 antisense (LASP1-AS) and its sense-cognate gene LIM and SH3 protein 1 (LASP1) were upregulated in HCC and both are correlated with poorer prognosis and lower survival of HCC patients. No 30677131 KCNQ1OT1 LncRNA Homo sapiens Stomach Neoplasms GC patients Interaction(KCNQ1OT1/ miR-378a-3p/ RBMS1 Axis ) Bioinformatics Analysis Importantly, we found that the KCNQ1OT1/miR-378a-3p/RBMS1 axis may play a vital role in the diagnosis and prognosis of GC patients based on Cox regression analyses. Furthermore, our findings demonstrated that mutations and sCNA of the KCNQ1OT1/miR-378a-3p/RBMS1 axis were associated with increased immune infiltration, while the abnormal upregulation of the axis was primarily a result of hypomethylation. No 35910231 LANCL1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[lower expressed] qRT-PCR//Microarray The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated). No 32020063 LAMTOR5-202 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 LAMTOR4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LAMA5-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma project Regulation Bioinformatics Analysis We developed a five-lncRNA signature as a potential prognostic indicator for osteosarcoma. The AUC for predicting 5-year survival was 0.745, which suggested good performance of the five-lncRNA signature. No 33964903 LACTB2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KRT88P LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 837 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 KRT42P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KRT4 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC and para-carcinoma tissues Expression[Expression[lower expressed]-expression] qRT-PCR//Microarray The qRT-PCR assay showed the Expression[Expression[up-expression]-expression]regulation of miR-455-5p, miR-21-3p, miR-96-5p, miR-93-5p, RP11-973H7.5, and HOXC10 expression in LSCC as well as the Expression[down-expression]regulation of miR-486-5p, LINC00657, CTC-297N7.9, hsa_circ_0008832, hsa_circ_0033988, hsa_circ_0001445, hsa_circ_0007013, KRT4, HOPX, TGFBR2, and KDR expression in LSCC (Fig. 10). No 30128795 KRT16P2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KRASP1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)67) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 KPNA1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KMT2C CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 KMD5B LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-21A) Expression[no-differently] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD15 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 KLRA1P LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 729 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 KLK8 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Expression(markedly upregulated) qRT-PCR//Western Blot KLK8 was markedly upregulated in colon cancer tissues in comparison with normal tissues, and its expression was related to tumor size, TNM stage, and metastasis, and positively correlated with the expression of CSCs-related genes in colon cancer tissues. KLK8 was markedly upregulated in colon cancer tissues in comparison with normal tissues, and its expression was related to tumor size, TNM stage, and metastasis, and positively correlated with the expression of CSCs-related genes in colon cancer tissues. No 34271345 KLK13 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KLHDC7B-DT LncRNA Homo sapiens Sjogren's Syndrome blood Expression[highly expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 KLF6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KLF3-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KLF3-AS1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 924 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 Klf10-205 LncRNA Rattus norvegicus Colorectal Neoplasms HCT116 cell Interaction(binding HDAC1 and EZH2 via ENSG00000274093.1.) qRT-PCR//RNA Pull-Down//Transwell Assay//FISH In this study, we identified that HDAC2 expression levels are associated with liver metastasis, higher T stages and poor prognosis in colorectal cancer. HDAC2 down-regulation via lentivirus-mediated expression of HDAC2-targeting shRNA reduced the in vitro migration and invasion ability of HCT116 cell as well as their liver metastasis in nude mouse xenografts. Mechanistically, HDAC2 promotes epithelial-mesenchymal transition (EMT) in colorectal cancer cells by combining HDAC1 with EZH2 (a key histone methyltransferase), possibly through the modular scaffold function of a new lncRNA, ENSG00000274093.1. HDAC2 thus appears to promote CRC cell migration and invasion through binding HDAC1 and EZH2 via ENSG00000274093.1. In this study, we identified that HDAC2 expression levels are associated with liver metastasis, higher T stages and poor prognosis in colorectal cancer. No 33325150 KLF10 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KIR3DX1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 KIF4A CircRNA Homo sapiens Breast Neoplasms breast cancer cell lines and tissues Interaction( circKIF4A-miR-335-OCT4/ALDOA-HK2/PKM2 axis) Western Blot//qPCR//RIP//IF//PCR//IP//Transwell Assay circKIF4A was overexpressed in breast cancer cell lines and tissues, inhibiting its expression and suppressing breast cancer growth and metastasis. Interestingly, we observed that circKIF4A reprogrammed the glucose metabolism of breast cancer, and silencing circKIF4A greatly affected glucose uptake and lactate production in breast cancer cells. miR-335 can be sponged by circKIF4A, which affected the expression of ALDOA/OCT4 protein and regulated HK2/PKM2 expression. No 36052282 KIF18B CircRNA Homo sapiens Alzheimer Disease cerebrospinal fluid Expression[lower expressed] qRT-PCR//Microarray By RT-qPCR, circ-LPAR1, circ-AXL and circ-GPHN were increased, whereas circ-PCCA, circ-HAUS4, circ-KIF18B and circ-TTC44C were decreased in AD patients compared with Ctrl subjects, and these circRNAs were disclosed to predict AD risk by receiver operating characteristics curve analysis. No 32315771 KIAA0319L CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 KDR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC and para-carcinoma tissues Expression[Expression[lower expressed]-expression] qRT-PCR//Microarray The qRT-PCR assay showed the Expression[Expression[up-expression]-expression]regulation of miR-455-5p, miR-21-3p, miR-96-5p, miR-93-5p, RP11-973H7.5, and HOXC10 expression in LSCC as well as the Expression[down-expression]regulation of miR-486-5p, LINC00657, CTC-297N7.9, hsa_circ_0008832, hsa_circ_0033988, hsa_circ_0001445, hsa_circ_0007013, KRT4, HOPX, TGFBR2, and KDR expression in LSCC (Fig. 13). No 30128795 KCNQ5-IT1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 913 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC02195 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues and HNSCC cell lines Expression[highly expressed] ISH//qRT-PCR//Western Blot qRT-PCR revealed high expression of LINC02195 in human HNSCC tissues and HNSCC cell lines compared with normal mucosal tissues. No 32435615 LINC02200 LncRNA Homo sapiens laryngeal squamous cell carcinoma LSCC tissues and cell lines regulation[ RP11-159K7.2/miR-206/DNMT3A axis] qRT-PCR Briefly, in situ hybridization (ISH) and real-time quantitative PCR (RT-qPCR) showed higher expression of RP11-159K7.2 in LSCC tissues and cell lines.Mechanically, we found that RP11-159K7.2 could positively regulate the expression of DNMT3A by sponging miR-206. In addition, a feedback loop was also discovered between DNMT3A and miR-206. Patients with low expression level of RP11-159K7.2 lived longer compared to those with high expression of RP11-159K7.2 (χ2 = 39.111, ***P < 0.001). No 32363688 LINC02237 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[lower expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 LNCV6_80954_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_80834_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_80788_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_80031_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_79975_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_79853_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_79785_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_78451_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_77511_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_77465_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_77055_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_76959_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_75454_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_75422_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_75002_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_74960_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_74534_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_74377_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_73977_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_73632_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_72936_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_72705_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_71744_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_71382_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_71323_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_71305_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_71004_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_70973_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_70591_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_70531_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_80933_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_81177_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_70504_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_81185_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_89446_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_89229_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_88831_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_88642_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_87574_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_87353_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_87341_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_87264_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_86813_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_86461_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_86139_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_86042_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_85861_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_85847_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_85567_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_85308_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_85249_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_84819_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_84780_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_84453_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_84003 LncRNA Homo sapiens Colorectal Neoplasms Exosomes from the plasma Expression[highly expressed] qRT-PCR The expression of six lncRNAs (LNCV6_116109, LNCV6_98390, LNCV6_38772, LNCV_108266, LNCV6_84003, and LNCV6_98602) was found to be significantly up-regulated in CRC patients compared with that in healthy individuals by qRT-PCR. No 30562751 LNCV6_83705_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_82424_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_82101_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_81862_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_81856_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_81854_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_81769_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_81710_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_70521_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_70453_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_89541_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_58830_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_58603_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_57961_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_57526_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_56841_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_56677_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_56040_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_55883_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_55749_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_55682_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_55155_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_54143_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_53864_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_53768_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_53678_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_53644_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_53593_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_53411_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_52918_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_52326_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_52181_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_52044_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_51811_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_51731_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_51491_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_50084_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_49804_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_47892_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_47377_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_47365_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_58826_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_59265_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_70211_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_59393_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_70137_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_69728_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_69679_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_69643_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_69610_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_69539_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_69351_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_69146_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_69084_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_69073_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_68349_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_68221_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_67403_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_67270_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_67064_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_67028_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_66664_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_66579_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_66106_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_65999_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_63690_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_63481_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_61964_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_61891_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_61381_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_61188_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_60734_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_60324_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_60106_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_89487_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_90106_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_45305_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LOC100421580 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 830 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100421523 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] qRT-PCR//RNA-seq Among the 557 lncRNAs, 30 and 542 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100421472 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 993 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100421438 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 633 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100421309 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 590 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100421166 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 529 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100421109 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1071 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100421061 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 584 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100420958 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 589 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100420902 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 940 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100420429 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 826 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100420277 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1082 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100420110 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 650 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100420050 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1014 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100419911 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 756 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100419844 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1013 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100419814 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1046 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100419786 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 803 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100419706 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 662 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100419506 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 859 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100419108 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 967 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100419073 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 782 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100335030 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100335030 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 543 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100313968 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1060 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100289511 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100289230 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 890 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100289019 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)78) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 LOC100288798 LncRNA Homo sapiens Breast Neoplasms serum of BC patients and healthy subjects Expression [lower expressed] RNA-seq After a comprehensive comparison of the BC patients and healthy subjects, we discovered five up-regulated exo-lncRNAs and six down-regulated exo-lncRNAs of interest.  No 34733934 LOC100288637 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100421561 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 615 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100421742 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1083 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100287825 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 960 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100422271 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 953 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100996447 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100996255 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100911717 LncRNA Rattus norvegicus Myocardial Infarction macrophages, heart tissues Interaction(GAP43) In Vivo Experiment//RNA Pull-Down//Western Blot//Tunel//qRT-PCR//RNA-seq//H&E Staining//IHC//IF The data revealed that lncRNA LOC100911717 was upregulated in M1-type macrophages but not in M0-type macrophages. In addition, the lncRNA LOC100911717 was upregulated in heart tissues after MI. Furthermore, an RNA pull-down assay revealed that lncRNA LOC100911717 could interact with growth-associated protein 43 (GAP43). Essentially, immunofluorescence assays and programmed electrical stimulation demonstrated that GAP43 expression was suppressed and VA incidence was reduced after lncRNA LOC100911717 knockdown in rat hearts using an adeno-associated virus. No 36684596 LOC100507599 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100507477 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 533 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100507236 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 739 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100507103 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 921 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100507091 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100507053 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)19) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 LOC100507053 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC patients Expression(lower expressed) qRT-PCR Among dysregulated lncRNAs, we observed LINC00324 significantly upregulated (2.11-fold; p-value = 0.0032) and LOC100507053 significantly downregulated (2.22-fold; p-value = 0.0001) in ESCC patients. No 35237522 LOC100507006 LncRNA Homo sapiens Ischemic Stroke peripheral whole blood Regulation qPCR Among the nine selected lncRNAs verified by qPCR, NR_120420 (OR 1.29, 95% CI 1.02-1.65, P = 0.037) was found independently associated with AIS after balancing patient baseline characteristics. The receiver operating characteristic (ROC) analysis concerning NR_120420 in total anterior circulation infarction subgroup showed that the area under the curve was 0.86 (95% CI: 0.73-0.99, P = 0.003), and at the optimal cutoff point of 1.93, the sensitivity and specificity reached 85.7% and 84.6%, respectively. No 35251465 LOC100506990 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100506974 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 883 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100506895 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100506746 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100506606 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 677 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100506497 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100506497 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 943 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100506207 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 616 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100506159 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100506100 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100506023 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 742 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100505918 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100505876 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 LOC100505874 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100505782 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100422717 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 906 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100422432 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 701 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100422296 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 892 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100288152 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100216355 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1017 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LNCV6_90159_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_98791_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_98634_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_98602 LncRNA Homo sapiens Colorectal Neoplasms Exosomes from the plasma Expression[highly expressed] qRT-PCR The expression of six lncRNAs (LNCV6_116109, LNCV6_98390, LNCV6_38772, LNCV_108266, LNCV6_84003, and LNCV6_98602) was found to be significantly up-regulated in CRC patients compared with that in healthy individuals by qRT-PCR. No 30562751 LNCV6_98584_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_98526_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_98390 LncRNA Homo sapiens Colorectal Neoplasms Exosomes from the plasma Expression[highly expressed] qRT-PCR The expression of six lncRNAs (LNCV6_116109, LNCV6_98390, LNCV6_38772, LNCV_108266, LNCV6_84003, and LNCV6_98602) was found to be significantly up-regulated in CRC patients compared with that in healthy individuals by qRT-PCR. No 30562751 LNCV6_98364_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_98359_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_98284_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_97685_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_97294_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_96385_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_96220_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_95733_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_95038_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_94889_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_94288_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_94239_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_93989_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_93960_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_93883_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_93880_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_93778_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_93717_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_93016_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_92710_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_92546_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_92248_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_90954_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_90295_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_98764_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_98871_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LOC100216337 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 880 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LNCV6_98990_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LOC100133315 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100133091 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100133091 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 563 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100132352 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 LOC100132280 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 534 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100131626 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100131564 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 558 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100131315 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100131257 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1023 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100130950 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100130899 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100130876 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1022 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100130783 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1030 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100130691 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100130632 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 875 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100130476 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100130417 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 791 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100130264 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100129434 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100129223 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 966 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LOC100128770 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100128531 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100128164 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LOC100128006 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 lnrCXCR4 LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 LNC-ZNF33B-2:1 LncRNA Homo sapiens Sepsis LNC-ZNF33B-2:1 gene Mutation(rs579501 polymorphism) Genotyping Our findings showed that the lnc-ZNF33B-2:1 rs579501 CC genotype increases the susceptibility to sepsis. From the medical perspective, the lnc-ZNF33B-2:1 rs579501 CC genotype could be serving as a biochemical marker for sepsis. Unconditional multiple logistic regression based on the recessive model (adjusted odds ratio = 2.026, 95% CI = 1.156-3.551, p = 0.0136) showed that patients with the CC genotype of rs579501 had increased risk of sepsis. Stratification analysis by age and gender indicated that patients with the rs579501 CC genotype had higher risk of sepsis among children aged <12 months (adjusted odds ratio = 2.638, 95% CI = 1.167-5.960, p = 0.0197) and in male patients (adjusted odds ratio = 2.232, 95% CI = 1.127-4.421, p = 0.0213). We also found a significant relationship between rs579501 and severe sepsis risk (CC versus AA/AC: adjusted odds ratio = 2.466, 95% CI = 1.346-4.517, p = 0.0035). No 36419831 lnc-ZFAS1 LncRNA Homo sapiens Ischemic Stroke peripheral blood mononuclear cells Expression(lower expressed) qRT-PCR//ELISA lnc-ZFAS1 was reduced in AIS patients compared to that in controls (Z = -10.693, p < 0.001). In AIS patients, lnc-ZFAS1 was negatively correlated with National Institutes of Health Stroke Scale score (rs = -0.335, p < 0.001), C-reactive protein (rs = -0.284, p < 0.001), tumor necrosis factor-alpha (rs = -0.293, p < 0.001), interleukin-1β (rs = -0.149, p = 0.021), and interleukin-6 (rs = -0.161, p = 0.012), but not underlying diseases (all p > 0.05). Besides, lnc-ZFAS1 was divided into high and low levels based on the median expression in AIS patients. Indeed, high lnc-ZFAS1 predicted better RFS (χ2 = 6.222, p = 0.013); the 1-year, 2-year, and 3-year RFS rates were 94.2%, 88.3%, and 85.5%, respectively, in patients with high lnc-ZFAS1, then 87.5%, 79.2%, and 71.6%, respectively, in those with low lnc-ZFAS1. However, lnc-ZFAS1 was not correlated with OS (χ2 = 1.404, p = 0.236); the 1-year, 2-year, and 3-year OS rates were 98.3%, 95.8%, and 94.0%, respectively, in patients with high lnc-ZFAS1, then 96.7%, 93.9%, and 89.6%, respectively, in those with low lnc-ZFAS1. lnc-ZFAS1 was reduced in AIS patients compared to that in controls (Z = -10.693, p < 0.001). In AIS patients, lnc-ZFAS1 was negatively correlated with National Institutes of Health Stroke Scale score (rs = -0.335, p < 0.001), C-reactive protein (rs = -0.284, p < 0.001), tumor necrosis factor-alpha (rs = -0.293, p < 0.001), interleukin-1β (rs = -0.149, p = 0.021), and interleukin-6 (rs = -0.161, p = 0.012), but not underlying diseases (all p > 0.05). No 34970793 lnc-XR_429159.1 LncRNA Homo sapiens Small Cell Lung Carcinoma 11 patients with BM and 11 patients without BM Expression(lower expressed) Microarray Four lncRNAs were verified by quantitative real-time polymerase chain reaction (qRT-PCR) to confirm the accuracy of the microarray data, and the results of 11 patient pairs (11 patients with BM and 11 patients without BM) revealed that low LncRNA XR_429159.1 expression was a high-risk factor for BM. Further clinical data showed that the incidence of BM among 25 patients with low-level LncRNA XR_429159.1 expression was 31% at 1 year, compared with 14.3% among the 18 patients with high-level LncRNA XR_429159.1 expression (p = 0.035). No 34079751 LNCV6_99023_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_45647_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_45091_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LINC02295 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[lower expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 lnc-COL20A1 LncRNA Homo sapiens Arthritis, Gouty blood Expression[highly expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 lnc-APTX-1 LncRNA Homo sapiens Arthritis, Gouty blood Expression[lower expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 lnc-AP000769.1–1 LncRNA Homo sapiens Arthritis, Gouty blood Expression[highly expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 lnc-AL928768.3 LncRNA Homo sapiens Arthritis, Rheumatoid synovium tissue Expression[highly expressed] qRT-PCR//RNA-seq Subsequent qPCR validation discovered that lnc-AL928768.3 (P < 0.001) and lnc-AC091493.1 (P < 0.001) were elevated in patients with RA compared with controls and afford good predictive values for RA risk by receiver operating characteristic (ROC) curve analysis. Additionally, the two lncRNAs were positively associated with C-reactive protein level and disease activity score in 28 joints (ESR) (all P < 0.05). No 31781981 lnc-AL445989.1-2 LncRNA Homo sapiens Alzheimer Disease blood Expression[highly expressed] qRT-PCR//Microarray As shown in Fig. 4, compatible with microarray results, expression of lncRNA lnc-AL445989.1-2, TTC39C-AS1, and LINC01420 is significantly high, and lnc-CSTB-1 and LOC401557 are significantly low in the patient group when compared with control groups. No 32885358 Lnc-AKTIP LncRNA Homo sapiens Sinonasal Inverted Papilloma SNIP tissues Expression(lower expressed) qRT-PCR//Bioinformatics Analysis//Microarray Lnc-AKTIP might interact with a variety of tumor-associated proteins and transcription factors, such as PCBP2, IRF-1, and p53. Receiver operating characteristic curve analysis for lnc-AKTIP showed an area under the curve of 0.939. Notably, its expression level was significantly decreased in SNIP tissues versus normal tissues and was associated with SNIP staging. Lnc-AKTIP may serve as a valuable diagnostic biomarker and a therapeutic target for SNIP. No 35186045 lnc-AC131097.3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck TCGA Regulation Bioinformatics Analysis PD-1 mRNA and AC131097.3 lncRNA expression correlated inversely with promoter and positively with gene body CpG methylation. PD-1 and AC131097.3 are co-expressed. Methylation was sequence-contextually associated with human papillomavirus prognosis, mutational load, and immune infiltrates. No 33351665 lnc-AC091493.1 LncRNA Homo sapiens Arthritis, Rheumatoid synovium tissue Expression[highly expressed] qRT-PCR//RNA-seq Subsequent qPCR validation discovered that lnc-AL928768.3 (P < 0.001) and lnc-AC091493.1 (P < 0.001) were elevated in patients with RA compared with controls and afford good predictive values for RA risk by receiver operating characteristic (ROC) curve analysis. Additionally, the two lncRNAs were positively associated with C-reactive protein level and disease activity score in 28 joints (ESR) (all P < 0.05). No 31781981 lnc-ABCC5-2:1 LncRNA Homo sapiens Stomach Neoplasms GC patients Regulation qRT-PCR//Bioinformatics Analysis//Microarray Nine miRNAs and eight lncRNAs were obtained from the microarray analysis. Six miRNAs (miR-550a-5p, miRNA-936, miR-1306-3p, miR-3185, miR-6083, miR-6792-3p) and three lncRNAs (lnc-MB21D1-3:5, lnc-PSCA-4:2 and lnc-ABCC5-2:1) were abnormally expressed in circulating and tissue samples compared with normal control (NC), which was closely related to clinical pathology and survival time of GC patients; circRNA sequencing and qRT-PCR revealed four circRNAs (circASHL2, circCCDC9, circNHSL1 and cirMLLT10) were abnormally expressed in GC tissues and parts of them were negative relationship with their predicted binding miRNAs. No 34295803 Lnc5150 LncRNA Homo sapiens Lupus Erythematosus, Systemic blood Expression[lower expressed] qRT-PCR Lnc5150 expression levels were statistically significantly decreased (Z=-6.016, P < 0.001) compared with normal controls. No 31563860 lnc34a LncRNA Homo sapiens Carcinoma, Hepatocellular serum from HCC patients with bone metastasis Expression(highly expressed) qRT-PCR Expression levels of lnc34a in serum from HCC patients with bone metastasis were significantly higher than those without bone metastasis. The high expressions of lnc34a, vascular invasion and Barcelona Clinic Liver Cancer (BCLC) stage were associated with bone metastasis by analysis. Moreover, lnc34a expression was specifically associated with bone metastasis rather than lung or lymph node metastasis in HCC. No 33588789 lnc030 LncRNA Homo sapiens Breast Neoplasms breast cancer stem cells Expression[highly expressed] RNA Pull-Down//Western Blot//Flow Cytometry//FISH//qRT-PCR//RIP//IHC//IF Herein, using lncRNA/mRNA microarray assays, a novel lncRNA (named lnc030) is identified, which is highly expressed in BCSCs in vitro and in vivo, as a pivotal regulator in maintaining BCSC stemness and promoting tumorigenesis. No 33511005 lnc_635 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[highly expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 lnc_582 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[lower expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 lnc_167 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[lower expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 lnc_1128 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[lower expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 LNC_11 LncRNA Homo sapiens lung squamous cell carcinoma LUSC samples Expression[highly expressed] CCK8//Colony Formation Assay//Flow Cytometry//Western Blot Our results showed that CTD-2562J17.6 and FENDRR were significantly downregulated while MIR205HG, LNC_000378, RP11-116G8.5, RP3-523K23.2, and RP5-968D22.1 were significantly upregulated in all five LUSC samples. Importantly, MIR205HG was upregulated in LUSC clinical samples as well as in LUSC cell lines. No 32188965 lnc_1095 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[lower expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 lnc_1072 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[highly expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 lnc_1061 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[highly expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 lnc_1054 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[highly expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 lnc_1051 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[lower expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 lnc_1018 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[highly expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 LNC_001072 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 4. No 30974198 LNC_000827 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 8. No 30974198 LNC_000480 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 2. No 30974198 LNC_000479 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 3. No 30974198 LNC_000201 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[lower expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 10. No 30974198 LNC_000009 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 5. No 30974198 lnc-ATMIN-4:2 LncRNA Homo sapiens Stomach Neoplasms AGC tissue Expression(highly expressed) ISH//RNA-seq High (>30 dots) lnc-ATMIN-4:2 expression significantly correlated with younger age, poorly differentiated histology, diffuse type, deeper invasion depth, perineural invasion, lymph node metastasis, and higher stage group. In addition, high lnc-ATMIN-4:2 expression was significantly associated with worse overall survival in patients with AGC. High (>30 dots) lnc-ATMIN-4:2 expression significantly correlated with younger age, poorly differentiated histology, diffuse type, deeper invasion depth, perineural invasion, lymph node metastasis, and higher stage group. In addition, high lnc-ATMIN-4:2 expression was significantly associated with worse overall survival in patients with AGC. No 36316044 lnc-CPLC LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction(miR-4319/ZBTB34 signal axis ) qRT-PCR//FISH//Luciferase Report Assay//Western Blot We found that ZBTB34 and lnc-CPLC (CRC progression-associated lncRNA) had a strong correlation, which plays a key role in the regulation of CRC. Our results reveal the mechanism of the lnc-CPLC/miR-4319/ZBTB34 signal axis in CRC and provide evidence for elucidating the complex molecular mechanisms in tumors. No 34741317 LMTK3-201 LncRNA Homo sapiens acral lentiginous melanoma tumor and six adjacent non-tumor tissues Expression[lower expressed] qRT-PCR//Microarray The top 5 downregulated lncRNAs were TCONS_00013495, T367528, ENST00000598924, T050010 and TCONS_00010142. No 31966073 lnc-CSTB-1 LncRNA Homo sapiens Alzheimer Disease blood Expression[lower expressed] qRT-PCR//Microarray As shown in Fig. 4, compatible with microarray results, expression of lncRNA lnc-AL445989.1-2, TTC39C-AS1, and LINC01420 is significantly high, and lnc-CSTB-1 and LOC401560 are significantly low in the patient group when compared with control groups. No 32885358 LNCNEF LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Tumor and adjacent healthy tissue samples Expression[lower expressed] qRT-PCR//Western Blot Expression of lncRNA-NEF is downregulated in tumor tissues, compared with adjacent healthy tissues in patients with NSCLC It was identified that lncRNA-NEF was downregulated in NSCLC tissues, compared with healthy controls, and the serum level of lncRNA-NEF was negatively associated with primary tumor stage. Therefore, serum lncRNA-NEF may be a sensitive diagnostic and prognostic marker for NSCLC. No 30854054 LNCNEF LncRNA Homo sapiens Spondylitis, Ankylosing synovial fluid of AS patients Expression(highly expressed) qRT-PCR//Transfection//Western Blot Our study observed that lncRNA-NEF expression was upregulated in synovial fluid of AS patients and significantly correlated with the ASDAS 1-4, BASDAI, erythrocyte sedimentation rate (ESR), and C-reactive protein level (p < .05). Treatment with nonsteroidal anti-inflammatory drugs significantly downregulated lncRNA-NEF expression (p < .01). A 3-year follow-up showed that patients with high lncRNA-NEF levels had a high recurrence rate (hazard ratio = 2.266). No 35894706 lnc-MSRB3-5:1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 lnc-MICAL3-2 LncRNA Homo sapiens Breast Neoplasms breast cancer samples Expression [lower expressed] Bioinformatics Analysis Expression levels of lnc-MICAL3-2, lnc-DDX31, LINC01063, LINC02381, ENST0000615051 and lnc-TRIM43B-1 were significantly decreased in breast cancer samples compared with paired control tissues (Posterior mean difference= -2.774, -2.012, -2.012, -2.015, -0.884 and -2.872; P values= 0.019, 0.0001, 0.0001, 0.0001, 0.032 and 0.0001, respectively). No 34175685 lnc-MEG3 LncRNA Homo sapiens Ischemic Stroke peripheral blood mononuclear cells Regulation(miR-21) qRT-PCR//ELISA Lnc-MEG3 expression was increased in AIS patients and could differentiate AIS patients from controls using receiver operating characteristic (ROC) curve analysis with area under the curve (AUC) of 0.874 and a 95% confidence interval (CI) of 0.833-0.914. Lnc-MEG3 expression was positively correlated with tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-17A and the National Institutes of Health Stroke Scale (NIHSS) score, and its high expression was also correlated with elevated accumulating recurrence rate in AIS patients. In addition, lnc-MEG3 expression was negatively correlated with miR-21 expression in AIS patients. Regarding miR-21, it was reduced in AIS patients and could differentiate AIS patients from controls with AUC of 0.889 (95% CI: 0.850-0.927). Lnc-MEG3 expression was positively correlated with tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-17A and the National Institutes of Health Stroke Scale (NIHSS) score, and its high expression was also correlated with elevated accumulating recurrence rate in AIS patients. No 34607195 lnc-MB21D1-3:5 LncRNA Homo sapiens Stomach Neoplasms GC patients Regulation qRT-PCR//Bioinformatics Analysis//Microarray Nine miRNAs and eight lncRNAs were obtained from the microarray analysis. Six miRNAs (miR-550a-5p, miRNA-936, miR-1306-3p, miR-3185, miR-6083, miR-6792-3p) and three lncRNAs (lnc-MB21D1-3:5, lnc-PSCA-4:2 and lnc-ABCC5-2:1) were abnormally expressed in circulating and tissue samples compared with normal control (NC), which was closely related to clinical pathology and survival time of GC patients; circRNA sequencing and qRT-PCR revealed four circRNAs (circASHL2, circCCDC9, circNHSL1 and cirMLLT10) were abnormally expressed in GC tissues and parts of them were negative relationship with their predicted binding miRNAs. No 34295803 LNC-MANSC4-8:1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 MALAT1 LncRNA Homo sapiens Cardiovascular Diseases AMI patients Expression(highly expressed) qRT-PCR//ELISA Lnc-MALAT1 was higher in AMI patients than in controls (median: 2.245 vs. 0.996, p = 0.004), and it also presented a good capacity for differentiating AMI patients from controls with an area under the curve of 0.823. Meanwhile, lnc-MALAT1 was positively associated with tumor necrosis factor-alpha (p = 0.001), interleukin (IL)-6 (p = 0.031), IL-17A (p = 0.042), vascular cell adhesion molecule-1 (p = 0.004), and intercellular adhesion molecule-1 (p = 0.021) among AMI patients. Importantly, after categorization, lnc-MALAT1 high (vs. low) was related to an elevated MACE accumulation rate (p = 0.035); furthermore, a higher lnc-MALAT1 quartile showed a trend to be linked with an increased MACE accumulation rate (p = 0.092). Lnc-MALAT1 was higher in AMI patients than in controls (median: 2.245 vs. 0.996, p = 0.004), and it also presented a good capacity for differentiating AMI patients from controls with an area under the curve of 0.823. No 36378551 lnc-LOC LncRNA Homo sapiens acute promyelocytic leukemia BM and peripheral blood (PB) sample of APL, APL cell lines Expression(highly expressed) qRT-PCR Our results showed that BM lnc-LOC expression was significantly different between APL and healthy donors and non-APL AML. Lnc-LOC was upregulated in APL cell lines and downregulated after all-trans retinoic acid (ATRA)-induced myeloid differentiation, preliminarily verifying that lnc-LOC has the potential to be considered a treatment monitoring biomarker. PB lnc-LOC was positively correlated with BM lnc-LOC in APL patients, non-APL AML patients and healthy donors and decreased sharply after complete remission (CR). However, upregulated lnc-LOC was manifested in relapsed-refractory patients. A positive correlation was revealed between PB lnc-LOC and PML-RARα transcript levels in BM samples. Furthermore, we observed a positive correlation between PB lnc-LOC and BM lnc-LOC expression in APL patients, suggesting that lnc-LOC can be utilized as a noninvasive biomarker for MRD surveillance. No 35501730 LNC-LBCS LncRNA Homo sapiens Urinary Bladder Neoplasms BCSCs and cancer tissues Regulation[ lnc-LBCS-hnRNPK-EZH2-SOX2 regulatory axis] RNA Pull-Down//Western Blot//ISH//qRT-PCR//RIP//Microarray//IHC//ChIP Lnc-LBCS is significantly downregulated in BCSCs and cancer tissues, and correlates with tumor grade, chemotherapy response, and prognosis. The lnc-LBCS-hnRNPK-EZH2-SOX2 regulatory axis may represent a therapeutic target for clinical intervention in chemoresistant bladder cancer. Lnc-LBCS is significantly downregulated in BCSCs and cancer tissues, and correlates with tumor grade, chemotherapy response, and prognosis. No 30397178 LNC-LBCS LncRNA Homo sapiens Prostatic Neoplasms CRPC cells lines and tissues Interaction[hnRNPK] RNA Pull-Down//Western Blot//qPCR//RIP//MTT//Microarray//IHC//ChIP The expression of Lnc-LBCS was lower in CRPC cells lines and tissues. Lnc-LBCS functions as a novel AR translational regulator that suppresses castration resistance of prostate cancer by interacting with hnRNPK. This sheds a new insight into the regulation of CRPC by lncRNA mediated AR activation and LBCS-hnRNPK-AR axis provides a promising approach to the treatment of CRPC. LBCS downregulation was correlated with higher Gleason Score, T stage and poor prognosis of PCa patients. No 31221168 LNC-LBCS LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 lnc-KRT79-1:1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 lnc-KCNT2 LncRNA Homo sapiens Arthritis, Gouty blood Expression[lower expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 lnc-ITGB7-5:2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 lnc-ICOSLG-11:1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR Finally, three lncRNAs, including ENST00000522221, lnc‑HACE1‑6:1 and lnc‑ICOSLG‑11:3, are significantly upregulated in HCC tissues compared with adjacent tumor‑free tissues. No 31485608 lncIAPF LncRNA Homo sapiens Pulmonary Fibrosis fibroblast Regulation In Vivo Experiment//Wound Healing Assay//Migration Assay//FISH//RIP Here, highly upregulated LINC00941/lncIAPF was found to accelerate pulmonary fibrosis by promoting fibroblast-to-myofibroblast differentiation and myofibroblast proliferation and migration. No 35427207 lncHDAC2 LncRNA Homo sapiens Liver Neoplasms cell lines Regulation[Hedgehog signaling ] Northern Blot//Flow Cytometry//RIP//IF//Luciferase Report Assay//IHC//ChIP LncHDAC2 is highly expressed in HCC tumors and liver CSCs. Our findings reveal that lncHDAC2 promotes the self-renewal of liver CSCs and tumor propagation by activating the Hedgehog signaling pathway. Downregulating lncHDAC2 is a promising antitumor strategy in HCC. No 30582981 lnc-HACE1-6:1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR Finally, three lncRNAs, including ENST00000522221, lnc‑HACE1‑6:1 and lnc‑ICOSLG‑11:2, are significantly upregulated in HCC tissues compared with adjacent tumor‑free tissues. No 31485608 lnc-GNAQ-6:1 LncRNA Homo sapiens Stomach Neoplasms blood Expression[lower expressed] qRT-PCR//Western Blot The results of qRT-PCR showed that compared with the healthy control, the expression of lnc-GNAQ-6:1 was significantly lower in the gastric cancer group. No 31730812 lnc-GAS5 LncRNA Homo sapiens Rhinitis, Allergic AR patients Interaction(miR-21 and miR-140) qRT-PCR Lnc-GAS5 was elevated, while miR-21 and miR-140 was downregulated in AR patients than in controls (p < 0.001).In AR patients, lnc-GAS5 was negatively correlated with miR-21 (p < 0.001), miR-140 (p < 0.001), IFN-γ (p = 0.019), and IL-2 (p = 0.039) and positively correlated with IL-4 (p = 0.004) and IL-10 (p < 0.001), individual nasal symptom scores (INSSs) for itching, sneezing, and congestion (p < 0.05), and total nasal symptom score (TNSS) (p < 0.001). No 34473845 lnc-FOXCUT LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Expression(highly expressed) Microarray The results of qRT-PCR confirmed notable upregulation of FOXC1, lnc-FOXCUT, and lnc-DANCR in TNBC tissues compared to non-TNBC samples (P < 0.0001, P = 0.0005, and P = 0.0008, respectively). Moreover, ROC curve analysis revealed the potential biomarker role of FOXC1 in TNBC samples. No 35066769 lnc-FAM72D-3 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR//RNA-seq lnc-FAM72D-3 expression in hepatitis, cirrhosis, and HCC groups was significantly high compared to the control group, while lnc-EPC1-4 expression in hepatitis, cirrhosis, and HCC groups was significantly low compared to the control group (Figure 4). No 32554864 lnc-EPC1-4 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[lower expressed] qRT-PCR//RNA-seq lnc-FAM72D-3 expression in hepatitis, cirrhosis, and HCC groups was significantly high compared to the control group, while lnc-EPC1-4 expression in hepatitis, cirrhosis, and HCC groups was significantly low compared to the control group (Figure 4). No 32554864 lncEPAT LncRNA Homo sapiens Glioblastoma glioma patients Interaction(EGFR-lncEPAT-ubH2A) FISH//qRT-PCR//IHC//IF LncEPAT was induced by the EGFR pathway, and high-level lncEPAT expression positively correlated with the glioma grade and predicted poor survival of glioma patients. Mass spectrometry analyses revealed that lncEPAT specifically interacted with deubiquitinase USP16. LncEPAT inhibited USP16's recruitment to chromatin, thereby blocking USP16-mediated H2A deubiquitination and repressing target gene expression, including CDKN1A and CLUSTERIN. Depletion of lncEPAT promoted USP16-induced cell cycle arrest and cellular senescence, and then repressed GBM cell tumorigenesis. LncEPAT was induced by the EGFR pathway, and high-level lncEPAT expression positively correlated with the glioma grade and predicted poor survival of glioma patients. No 36197973 lnc-DEFB132-1:1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 lnc-DDX31 LncRNA Homo sapiens Breast Neoplasms breast cancer samples Expression [lower expressed] Bioinformatics Analysis Expression levels of lnc-MICAL3-2, lnc-DDX31, LINC01063, LINC02381, ENST0000615051 and lnc-TRIM43B-1 were significantly decreased in breast cancer samples compared with paired control tissues (Posterior mean difference= -2.774, -2.012, -2.012, -2.015, -0.884 and -2.872; P values= 0.019, 0.0001, 0.0001, 0.0001, 0.032 and 0.0001, respectively). No 34175685 lnc-DANCR LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Expression(highly expressed) Microarray The results of qRT-PCR confirmed notable upregulation of FOXC1, lnc-FOXCUT, and lnc-DANCR in TNBC tissues compared to non-TNBC samples (P < 0.0001, P = 0.0005, and P = 0.0008, respectively). Moreover, ROC curve analysis revealed the potential biomarker role of FOXC1 in TNBC samples. No 35066769 lnc-CXCR3-5:2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 LNBC3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues，cell lines Interaction[stabilizing BCL6 ] qRT-PCR//RIP LNBC3 is markedly overexpressed in tumor tissues and NSCLC cell lines. The antisense oligonucleotides (ASOs) targeting LNBC3 substantially inhibited lung cancer progression. Mechanistic studies showed that LNBC3 could interact with BCL6 leading to BCL6 stabilization through reduced proteasomal degradation. Higher LNBC3 levels correlated with advanced TNM stages, larger tumor size, and metastasis. LNBC3 promoted NSCLC migration and viability. The in vivo experiments demonstrated that xenograft tumor growth and proliferation were facilitated with increasing LNBC3 levels. No 31743519 LMO3 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 lncNR4A3 LncRNA Homo sapiens Leukemia, Myeloid, Acute Bone marrow cells regulation[NR4A3 ] qRT-PCR Bone marrow cells from AML patients expressed significantly reduced levels of lncNR4A3 compared to healthy controls (controls = 15, MDS= 20, p=0.05., AML= 21, p<0.01). We showed that this novel transcript, lncNR4A3 regulates NR4A3 and we hypothesize this regulatory mechanism is mediated by the modulation of the RNA processing machinery. No 33330042 LINC02985 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Expression(highly expressed) qRT-PCR//Bioinformatics Analysis We found that lncRNAs AC156455.1 and AC104532.2 were upregulated in twelve colorectal cancer tissues compared with adjacent normal tissues using qRT-PCR. No 36277972 LINC02908 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissue and serum regulation[ miR-663a/Sox12 axis] RNA Pull-Down//Western Blot//Co-IP//qRT-PCR//RIP//Luciferase Report Assay C9orf139 level significantly increased in the tissue and serum of patients, which had clinical diagnostic value for pancreatic cancer. The underlying mechanism of C9orf139 was that it promoted the growth of pancreatic cancer cells by modulating the miR-663a/Sox12 axis. Patients with high C9orf139 expression had a higher risk of progressing to stage III + IV, lymph node metastasis, and poor differentiation. Cox regression analysis suggested that C9orf139, tumor-node-metastasis stage, and lymph node metastasis were independent prognostic factors in patients. No 33250960 LINC02904 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC02899 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 738 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 LINC02893 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction( AL513318.2/hsa-miR-26a-5p/SLC6A8) IHC//Microarray In summary, the AL513318.2/hsa-miR-26a-5p/SLC6A8 network upregulates SLC6A8 expression in NSCLC and is associated with poor prognosis. In summary, the AL513318.2/hsa-miR-26a-5p/SLC6A8 network upregulates SLC6A8 expression in NSCLC and is associated with poor prognosis. No 35251966 LINC02882 LncRNA Homo sapiens Carcinoma, Hepatocellular blood,cell lines Interaction[microRNA-490-3p] CCK8//Wound Healing Assay//EdU Staining//Transwell Assay Here, we have identified a long non-coding RNA, RP11-81H3.2, which is enriched in HCC and can promote its proliferation, migration, and invasion both in vitro and in vivo. In addition, our results showed that RP11-81H3.2 binds to and regulate miR-490-3p expression in the HCC cells. Moreover, we found that RP11-81H3.2 regulates the expression of TNKS2 via miR-490-3p. Further, we found that RP11-81H3.2 and miR-490-3p form a regulatory loop; the release of RP11-81H3.2 leads to the suppression of miR-490-3p expression, thus, further enhancing the expression of RP11-81H3.2. No 31858324 LINC02832-204 LncRNA Homo sapiens Cardiovascular Diseases blood Expression[highly expressed] qRT-PCR//Microarray To validate the microarray data, four up-regulated lncRNAs (NR_037652.1, ENST00000607654.1, ENST00000589524.1 and uc004bhb.3) were selected based on the functional co-expression networks, the signal value and the validation of designed primers. A description of the four strictly screened lncRNAs is presented in Table 5. The four lncRNAs were all up-regulated between 50 Uyghur SAP patients and 50 matched controls, which were consistent with the microarray data (Figure 8). The characteristics of the 100 validated participants are shown in Table 6. For an in-depth understanding of the four lncRNAs, the target genes are mainly based on correlation of at least 0.8, not only the possible function (Supplementary Figure S1). No 31413167 LINC02832-202 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma plasma exosome Expression[highly expressed] qRT-PCR//RNA-seq Expression levels of the lncRNAs NR_039819, NR_036133, NR_003353, ENST00000442416.1, and ENST00000416100.4 were significantly higher in exosomes from ESCC patients than non-cancer controls. No 32597791 LINC02827 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 LINC02760 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 LINC02620 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 LINC02620 LncRNA Homo sapiens Osteosarcoma osteosarcoma specimens and cells Interaction(miR-1303/FGF7 axis) qRT-PCR//ELISA We illustrated that elevated expression of BCRT1 decreases miR-1303 expression in MG-63 cell. The expression of miR-1303 is lower in osteosarcoma specimens than in non-tumor specimens. There is an inverse interrelation between miR-1303 levels and BCRT1 levels in osteosarcoma specimens. Furthermore, we identified FGF7 is one direct target gene of miR-1303 in osteosarcoma cell. Ectopic expression of miR-1303 suppresses FGF7 expression and elevated expression of BCRT1 enhanced FGF7 expression in MG-63 cell. Finally, we illustrated that BCRT1 induces osteosarcoma cell cycle and proliferation and promotes EMT progression and inflammatory mediators secretion via modulating FGF7 expression. No 34102610 LINC02615 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression(lower expressed) qRT-PCR Data demonstrated that expression of LINC02615 was significantly downregulated in breast cancer tissues compared to the healthy controls (P=0.046). No 34455716 LINC02613 LncRNA Homo sapiens Breast Neoplasms tumor samples Expression(lower expressed) Bioinformatics Analysis The expression of LINC02613 was downregulated in tumor samples and was related to poor overall survival (OS) in breast cancer patients. Statistical analysis revealed that low expression of LINC02613 was associated with Asian ethnicity, older age, higher histological grade and higher expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). Positive expression of immunohistochemical markers (ER, PR and HER2), high pathological stage and N stage were independent predictors for low LINC02613 expression. Decreased expression of LINC02613 caused an increase in Wnt2 and Wnt3 protein expression, which activated the Wnt signaling pathway, thereby promoting cell cycle progression, DNA replication and glycolysis. At the same time, the antitumor immunity of the body was also weakened when the expression of LINC02613 was decreased. The expression of LINC02613 was downregulated in tumor samples and was related to poor overall survival (OS) in breast cancer patients. No 35571659 LINC02560 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression(highly expressed) qRT-PCR//Bioinformatics Analysis LINC02560 was significantly up-regulated in CRC in comparison to normal samples. There are significant differences in the expression of LINC02560 in different subgroups of N stage, M stage, carcinoembryonic antigen (CEA) level, residual tumor, TP53 status and pathological stage. The high LINC02560 expression indicated poor overall survival (OS) and progress free interval (PFI) in patients with CRC. No 35003370 LINC02555 LncRNA Homo sapiens lung squamous cell carcinoma TCGA(409 LSCC and 49 control samples) Regulation Bioinformatics Analysis Kaplan-Meier survival curves revealed prognostic capabilities for three of these lncRNAs (LINC02555, APCDD1L-DT and OTX2-AS1). A Cox regression analysis revealed this three-lncRNA signature to be significantly associated with patient survival. A Cox regression analysis revealed this three-lncRNA signature to be significantly associated with patient survival. No 33910626 LINC02544 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[highly expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 LINC02541-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC02487 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 LINC02471-201 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[lower expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 LINC02446 LncRNA Homo sapiens COVID-19 126 blood samples Expression(highly expressed) Bioinformatics Analysis Upon further investigation on an individually selected lncRNA level, some lncRNA genes were significantly enriched in the COVID-19/ICU, while some were enriched in the COVID-19/non-ICU group (Figures 5c and 5d). Selected lncRNAs are presented as violin plots depicting upregulation of LINC02207, AC020636.1, AC243967.2, LINC01127, AC00727.1 and AC092746.1 in the COVID-19/ICU group, whereas those enriched in the COVID-19/non-ICU group include LINC02084, LINC02446, LINC00861, AC015911.3, LINC01871 and ANKRD44-AS1 with ANOVA p values of <0.0001. No 33898797 LINC02432 LncRNA Homo sapiens pancreatic adenocarcinoma macrophage Interaction(LINC02432/Hsa-miR-98-5p/HK2) Bioinformatics Analysis In conclusion, our study suggested that LINC02432/hsa-miR-98-5p/HK2 axis may serve as a novel diagnostic, prognostic, and therapeutic target in PAAD treatment. No 35795552 LINC02428 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial 35 cases of EOC patients (malignant group) and 20 cases of benign ovarian tumor patients (benign group) Expression(lower expressed) qRT-PCR Compared with the benign and normal groups, the expression of FER1L6-AS2, LINC00470 and LINC01811 in malignant group increased by 1.66 and 1.84-fold, 2.05 and 2.46-fold, 2.94 and 2.35-fold, respectively; the expressions of CXXC4-AS1, LINC02343 and LINC02428 were down-regulated to 29% and 34%, 40% and 46%, 42% and 42%, respectively. No 35385957 LINC02402-201 LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 LINC02402-201 LncRNA Homo sapiens Polycystic Ovary Syndrome PCOS patients Expression(highly expressed) qRT-PCR We observed that the expression of lncRNA ENST00000550337.1 in PCOS patients was significantly higher than that in the control subjects and positively correlated with PCOS occurrence, waist circumference, waist-hip ratio, IR, fasting insulin levels, and blood glucose. Patients with elevated lncRNA ENST00000550337.1 expression had significantly increased PCOS risk after adjusting for age and BMI. The expression of lnc RNA ENST00000550337.1 was positively correlated with PCOS (p = 0.003). No 33601399 LINC02381 LncRNA Homo sapiens Breast Neoplasms breast cancer samples Expression [lower expressed] Bioinformatics Analysis Expression levels of lnc-MICAL3-2, lnc-DDX31, LINC01063, LINC02381, ENST0000615051 and lnc-TRIM43B-1 were significantly decreased in breast cancer samples compared with paired control tissues (Posterior mean difference= -2.774, -2.012, -2.012, -2.015, -0.884 and -2.872; P values= 0.019, 0.0001, 0.0001, 0.0001, 0.032 and 0.0001, respectively). No 34175685 LINC02381 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC02343 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial 35 cases of EOC patients (malignant group) and 20 cases of benign ovarian tumor patients (benign group) Expression(lower expressed) qRT-PCR Compared with the benign and normal groups, the expression of FER1L6-AS2, LINC00470 and LINC01811 in malignant group increased by 1.66 and 1.84-fold, 2.05 and 2.46-fold, 2.94 and 2.35-fold, respectively; the expressions of CXXC4-AS1, LINC02343 and LINC02428 were down-regulated to 29% and 34%, 40% and 46%, 42% and 42%, respectively. No 35385957 LINC02303-201 LncRNA Homo sapiens acral lentiginous melanoma tumor and six adjacent non-tumor tissues Expression[highly expressed] qRT-PCR//Microarray The top 5 upregulated lncRNAs were T380070, ENST00000554431, T097678, GSE61474_TCONS_00183926 and NR_015400. No 31966073 LINC02301-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 LINC02908-201 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR//Microarray After a multi-stage validation, we finally revealed three lncRNAs, ENSG00000248932.1, ENST00000440688.1 and ENST00000457302.2, increased in HCC comparing with the both chronic hepatitis (CH) patients and cancer-free controls. No 31811749 LINC02994-201 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Expression[highly expressed] qRT-PCR Microarray analysis identified 1850 lncRNAs with significant differential expression in ESCC. Of 22 lncRNAs selected for quantitative reverse transcription PCR verification, four were significantly upregulated and one was significantly downregulated in ESCC cancer compared to para-cancer tissues. ENST00000508406.1 was significantly associated with T, N, and tumor node metastasis stages, and NR_037652.1 was significantly associated with N stage. Moreover, 49 lncRNA-messenger RNA pairs were significantly associated with the two dysregulated lncRNAs and possibly involved in the regulation of local invasion and lymphatic metastasis of ESCC. ENST00000508406.1 was significantly associated with T, N, and tumor node metastasis stages, and NR_037652.1 was significantly associated with N stage. No 30390388 LMNB1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LINC03033 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LMLN LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 LMF1-AS1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LINREP LncRNA Homo sapiens Glioblastoma GBM tissues Regulation(PTBP1/HuR complex) In Vivo Experiment//Western Blot//Co-IP//RNA-seq//Microarray In present study, we provided evidences for the role of a long intergenic noncoding RNA (LINREP) implicated in the regulation of PTBP1-induced AS. LINREP interacted with PTBP1 and human antigen R (HuR, ELAVL1) protein complex and protected PTBP1 from the ubiquitin-proteasome degradation. Consequently, a broad spectrum of PTBP1-induced spliced variants was generated by exon skipping, especially for the skipping of reticulon 4 (RTN4) exon 3. Interestingly, LINREP also promoted the dissociation of nuclear UPF1 from PTBP1, which increased the binding of PTBP1 to RTN4 transcripts, thus enhancing the skipping of RTN4 exon 3 to some extent. Besides, HuR recruitment was essential for the stabilization of LINREP via a manner dependent on N6-methyladenosine (m6A) formation and identification. Taken together, our results demonstrated the functional significance of LINREP in human GBM for its dual regulation of PTBP1-induced AS and its m6A modification modality, implicating that HuR/LINREP/PTBP1 axis might serve as a potential therapeutic target for GBM. No 35871232 LINLK-A LncRNA Homo sapiens Stroke all stroke groups Expression(lower expressed) ELISA Remarkable upregulation of lncRNA HIF1A-AS2 and HIF1-α along with a downregulation of lncRNA LINK-A was noticed in all stroke groups relative to controls. No 34091825 LINC-ROR LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Expression[highly expressed] qRT-PCR//MTT//Transwell Assay The levels of ROR, HMGA2 were significantly upregulated, and miR-519d-3p was apparently downregulated in GC tissues and cells. No 32614615 LINC-ROR LncRNA Homo sapiens Stomach Neoplasms Gastric Cancer samples Interaction(SALL4 ) qRT-PCR Significant LINC-ROR underexpression and SALL4 overexpression were observed in 55.81% and 75.58% (p < 0.0001) of samples, respectively. The expression of LINC-ROR and SALL4 were significantly correlated with each other (p = 0.044). here was an association between the underexpression of LINC-ROR and sex, stage of tumor progression, tumor type, and location of tumor (p < 0.05), and Helicobacter pylori infection with SALL4 expression (p = 0.036). No 33745265 LINC-ROR LncRNA Homo sapiens Stomach Neoplasms gastric cancer samples Expression(lower expressed) RNA-seq Expression levels of LINC-ROR, HOXA-AS2 and MEG3 lncRNAs have been lower in gastric cancer samples compared with nearby non-cancerous samples (Expression ratios = 0.26, 0.37 and 0.36; P values = 0.021, 0.015 and 0.032, respectively). Expressions of LINC-ROR and HOXA-AS2 were not associated with any clinical or pathological parameter. ROC curve analysis revealed that HOXA-AS2 and LINC-ROR could significantly differentiate between gastric cancer samples and nearby non-cancerous tissues (AUC values = 0.68 and 0.64; P values = 0.01 and 0.04, respectively). No 36299522 LINC-ROR LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues Expression[highly expressed] qRT-PCR Expression levels of LINC-ROR and stemness-related factors: SOX2, NANOG, and POU5F1 were detected in 60 formalin-fixed, paraffin-embedded tissues, and their paired adjacent non-cancer tissues (n = 60) by using real-time qRT-PCR analysis. The genes studied were markedly up-regulated in RCC (medians and interquartile ranges were 30.3 (1.84-235.5), 10.2 (1.84-53.9), 5.39 (0.94-23.5), and 12.5 (1.61-43.2) for LINC-ROR, SOX2, NANOG, and POU5F1, respectively) relative to paired non-cancer tissue. High expression levels were associated with poor prognosis in terms of tumour undifferentiation (for LINC-ROR, SOX2, and NANOG), lymph node infiltration (for SOX2), postoperative recurrence (for LINC-ROR and SOX2), and shorter overall survival (OS) and progression-free survival (for all genes studied). The best curve for OS prediction was constructed with LINC-ROR data (area under the receiver operating characteristic curve (AUC) = 0.804 at a cut-off value of 72.7, sensitivity 78.9%, and specificity 80.5%). No 34336029 LINC-ROR LncRNA Homo sapiens Ovarian Neoplasms plasma Expression[highly expressed] qRT-PCR The expression of lncRNA ROR in the plasma of ovarian cancer patients was significantly higher than that in healthy controls. Further study showed that the expression of lncRNA ROR was closely related to FIGO stage, tumor grade, and lymph node metastasis. Pearson's correlation assay indicated that lncRNA ROR positively correlated with CA125 in ovarian cancer patients. No 32658434 LINC-ROR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 178 OSCCs and 191 controls Mutation(rs6420545 and rs4801078) qRT-PCR The frequency of linc-ROR rs6420545 and rs4801078 genotypes were significantly associated with advanced tumor grade (>2) (p = 0.002 and p = 0.048), and nodal metastasis (p = 0.001 and p = 0.019), respectively. We observed a significant association of rs6420545 specifically in the over-dominant model [OR 1.77 (95%CI; 1.17-2.68); p = 0.006] and rs9636089 in dominant model [OR 2.17 (95%CI; 1.06 - 4.46); p = 0.03], and allelic model [OR 2.26 (95%CI; 1.13 - 4.53) p = 0.02], respectively. Further, significant upregulation of linc-ROR (p = 0.005) was observed in our cohort, consistent with the HNSCC TCGA dataset (p < 0.0001). No 35461069 LINC-ROR LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis There were 8 researches participated by 720 patients. According to the HR, it has been implied that there was a high LncRNA ROR expression related with the weak disease-free survival (DFS) (HR = 3.48, 95% CI, 2.24-5.41) and overall survival (OS) (HR = 2.47, 95% CI, 1.76-3.47) among the cancer patients with none dramatic heterogeneity. There was also a correlation among lymph node metastasis (OR = 5.38, 95% CI, 2.21-13.12), high tumor stage (OR = 3.80, 95% CI, 1.95-7.41), and larger tumor size (OR = 4.43, 95% CI, 1.26-15.51). No 31124961 LINC-ROR LncRNA Homo sapiens Nasopharyngeal carcinoma NPC patients Expression(lower expressed) qPCR The median of TEP lncRNA ROR was significantly lower in NPC patients than that in normal subjects (0.0209 vs 0.0610, p = 0.0019), while no significant difference was found in plasma lncRNA ROR. No 36107245 LINC-ROR LncRNA Homo sapiens Glioblastoma glioblastoma cancer tissues Expression[highly expressed] qRT-PCR The up-regulation of LINC-ROR was encountered in 89.5% of patients. The higher expression of LINC-ROR was associated with poor disease progression-free and overall survival as well as a younger age of patients ( P=0.036). The up-regulation of LINC-ROR was encountered in 89.5% of patients. The higher expression of LINC-ROR was associated with poor disease progression-free and overall survival as well as a younger age of patients ( P=0.036). The Kaplan-Meier survival plot illustrated poor survival in glioblastoma patients with over-expressed LINC-ROR ( P=0.010) and down-regulated p53 ( P=0.002). No 30852975 LINC-ROR LncRNA Homo sapiens Multiple Sclerosis blood Expression[lower expressed] qRT-PCR Relative expressions of SPRY4-IT1, HOXA-AS2, LINC-ROR, and MEG3 were significantly lower in female MS patients compared with female healthy subjects. No 32578033 LINC-ROR LncRNA Homo sapiens Lupus Erythematosus, Discoid 163 SLE patients Mutation(rs1942347) Genotyping We aimed to explore the contribution of HOTAIR (rs10783618), LINC-ROR (rs1942347), and MALAT1 (rs3200401) variants to SLE susceptibility and/or severity in 163 SLE patients and age-/sex-matched controls using real-time TaqMan allelic discrimination PCR. HOTAIR rs10783618*C/C was associated with a 77% increased risk of SLE (OR = 1.77, 95%CI = 1.09?2.87, p = 0.020) under the recessive model. Similarly, MALAT1 rs3200401*T/T carriers were three times more likely to develop SLE (OR = 2.89, 95%CI = 1.42?5.90) under the recessive model. While the rs3200401*T/C genotype was associated with a 49?57% decreased risk of SLE under codominant (OR = 0.51, 95%CI = 0.31?0.82, p < 0.001) and over-dominant (OR = 0.43, 95%CI = 0.27?0.68, p < 0.001) models. LINC-ROR rs1942347*A/A patients were more likely to have a positive family history of SLE. At the same time, HOTAIR rs10783618*C/C was associated with a higher frequency of arthritis (p = 0.001) and the presence of oral ulcers (p = 0.002), while patients carrying rs10783618*T/T genotype were more likely to develop hair loss (p < 0.001), weight loss (p = 0.001), and neurological symptoms (p = 0.003). No 35626352 LINC-PINT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC serum samples and tissues Expression [lower expressed] qRT-PCR The results demonstrated that LINC-PINT expression was significantly downregulated in NSCLC serum samples and tissues. Furthermore, aberrant LINC-PINT expression in tumor tissues was significantly associated with lymph node metastasis, tumor size, differentiation and TNM stage. T No 33552292 LINC-PINT LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Expression[lower expressed] qRT-PCR qPCR results indicated marked upregulation of CDKN2A-AS1, C7orf55, LINC00184, HEIH, and ZEB2 expression, whereas that of SNHG3, LINC00630, LOC100133669, APTR, LINC-PINT, and SEMA5A was downregulated in OC tissues as compared with levels in normal ovary tissues (Fig. ?(Fig.5b5b). No 31098301 LINC-PINT LncRNA Homo sapiens laryngeal carcinoma laryngeal carcinoma tissues Expression[lower expressed] qRT-PCR LINC-PINT expression was downregulated in laryngeal tumors. No 31131448 LINC-PINT LncRNA Homo sapiens Pemphigus 227 endemic PF patients and 194 controls Mutation(rs10228040) qRT-PCR//Genotyping//Microarray Among them, the LINC-PINT SNP rs10228040*A (OR = 1.47, p = .012) was also associated with increased susceptibility for sporadic PF (OR = 2.28, p = .002). Moreover, the A+ carriers of LY86-AS1*rs12192707 mark lowest LY86-AS1 RNA levels, which might be associated with a decreasing autoimmune response. No 33394553 linc-GTF2H2-1 LncRNA Homo sapiens Lung Neoplasms tumor educated platelet Expression(lower expressed) qRT-PCR TEP linc-GTF2H2-1 and RP3-466P17.2 were significantly downregulated, while lnc-ST8SIA4-12 was significantly upregulated in patients with lung cancer or with early-stage lung cancer as compared to healthy donors, possessing AUCs of 0.781, 0.788, 0.725 for lung cancer and 0.704, 0.771, 0.768 for early-stage lung cancer, respectively. No 33792796 Linc-A LncRNA Homo sapiens Colorectal Neoplasms colon adenocarcinoma tissues Expression[highly expressed] qRT-PCR The levels of Linc-A in colon adenocarcinoma was higher than that in paracancerous tissues (p = 0.047). Furthermore, high expression of Linc-A was associated with advanced TNM stage (p = 0.013), positive lymph nodes (p = 0.024), low 5-year survival rate (p = 0.024) and even 10-year survival rate (p = 0.007). Besides, Linc-A, advanced age, advanced TNM stage, deep infiltration degree and positive lymph nodes were also found to be positively related to poor overall 5-year survival by Kaplan-Meier survival analysis(p < 0.05). No 32918124 Linc8986 LncRNA Homo sapiens Lupus Erythematosus, Systemic plasma Expression(highly expressed) qRT-PCR Compared with those in the healthy controls, the plasma levels of linc0597 and linc8986 were significantly increased in the patients with SLE (P<0.001), while the difference in the level of linc7190 was not significant (P=0.052). Compared with patients with SLE without lupus nephritis (LN), the levels of linc0597 were significantly higher in patients with LN (P=0.044). No 34584555 LINC342 LncRNA Homo sapiens Arthritis, Rheumatoid keen synovial tissues Expression[lower expressed] qRT-PCR Results of RT-qPCR showed that the levels of lncRNAs MTCO2P12, KCNQ5-IT1 and RP11-83J16.1 were increased, whereas lncRNAs LINC00570, RP11-342M1.6, and REXO1L7P were decreased in RA patients compared to controls. No 32355550 linc0597 LncRNA Homo sapiens Lupus Erythematosus, Systemic serum Expression[highly expressed] qRT-PCR//ELISA The LN group presented significantly higher serum sTNF-R1 and linc0597 levels than the control group and the SLE group. Besides, ROC curve analysis revealed that sTNF-R1 and linc0597 had good clinical diagnostic value in LN and SLE. No 32495893 linc0597 LncRNA Homo sapiens Lupus Erythematosus, Systemic plasma Expression(highly expressed) qRT-PCR Compared with those in the healthy controls, the plasma levels of linc0597 and linc8986 were significantly increased in the patients with SLE (P<0.001), while the difference in the level of linc7190 was not significant (P=0.052). Compared with patients with SLE without lupus nephritis (LN), the levels of linc0597 were significantly higher in patients with LN (P=0.044). No 34584555 LINC03093 LncRNA Homo sapiens Myasthenia Gravis Expression(highly expressed) qRT-PCR//RNA-seq We identified 378 significantly upregulated and 348 significantly downregulated lncRNAs in MG patients compared with HC. The top 5 lncRNAs (NR_104677.1, ENST00000583253.1, NR_046098.1, NR_022008.1, and ENST00000581362.1) were validated and shown to be significantly increased in the serum exosome of MG, and the expression level of NR_046098.1 significantly increased with the MG grading. No 33543801 LncNONMMUG027912 LncRNA Homo sapiens Non-alcoholic Fatty Liver Disease AML12 cells Regulation(AMPKα/mTOR/SREBP1C axis) Western Blot//qRT-PCR//Luciferase Report Assay//Oil Red O Staining//IF We found that upregulated lnc027912 in AML12 cells treated with oleic acid (OA) and palmitic acid (PA) showed a significant decrease in lipid accumulation, triglyceride (TG) levels, and lipid biosynthesis genes. In terms of regulatory mechanisms, lnc027912 increased the expression of p-AMPKα, inhibited p-mTOR levels, decreased the expression of SREBP1C in nuclei, decreased the promoter activity of SREBP1C, and inhibited the expression of lipid synthesis genes. Most importantly, lnc027912 could reduce lipid accumulation and liver inflammation through AMPKα/mTOR signal axis in nonalcoholic fatty liver disease (NAFLD) mice model. No 35714571 lnc-NR5A2-8:1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 LNCV6_44665_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_114832_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_114253_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_114234_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_114120_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_113897_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_113874_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_113855_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_113795_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_113645_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_113614_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_113155_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_112754_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_112704_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_112677_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_112213_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_112075_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_112046_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_111633_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_111553_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_111513_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_111350_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_111311_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_110896_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_110783_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_110644_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_110266_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_109781_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_109631_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_109087_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_108845_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_114762_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_115253_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_108640_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_115414_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_44364_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_44036_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_41364_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_40594_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_40399_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_40327_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_39071_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_38772 LncRNA Homo sapiens Colorectal Neoplasms Exosomes from the plasma Expression[highly expressed] qRT-PCR The expression of six lncRNAs (LNCV6_116109, LNCV6_98390, LNCV6_38772, LNCV_108266, LNCV6_84003, and LNCV6_98602) was found to be significantly up-regulated in CRC patients compared with that in healthy individuals by qRT-PCR. No 30562751 LNCV6_37572_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_126043_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_125822_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_125561_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_123997_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_123221_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_121956_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_121590_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_118800_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_117452_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_117378_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_117336_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_117144_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_116655_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_116508_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_116286_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_116256_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_116109 LncRNA Homo sapiens Colorectal Neoplasms Exosomes from the plasma Expression[highly expressed] qRT-PCR The expression of six lncRNAs (LNCV6_116109, LNCV6_98390, LNCV6_38772, LNCV_108266, LNCV6_84003, and LNCV6_98602) was found to be significantly up-regulated in CRC patients compared with that in healthy individuals by qRT-PCR. No 30562751 LNCV6_116089_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_115548_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_115452_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_108676_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_108378_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LncOb LncRNA Homo sapiens Non-alcoholic Fatty Liver Disease One-hundred five obese youths with NAFLD Mutation(rs10487505 ) In Vivo Experiment LncOb rs10487505 variant was associated with pediatric NAFLD and high leptin levels, and with weight and leptin reduction after LSG in youths. No 35354928 lnc-SPRR1B-1:1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 lncSNHG15 LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis The results demonstrated a positive correlation between high expression level of lncSNHG15 and short overall survival (hazard ratio (HR) = 2.07, 95% confidence interval (CI), 1.48-2.88; P<0.0001) and disease-free survival (DFS) (HR = 2.32, 95% CI, 1.53-3.53; P<0.0001). No 32633324 Lnc-SMIM20-1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML tissues and cells Expression(highly expressed) Bioinformatics Analysis Lnc-SMIM20-1 was most highly expressed in AML and up-regulated in the TCGA-AML cohort compared to normal tissues. Lnc-SMIM20-1 might participate in cancer-associated signaling pathways and immune-related signaling pathways by interacting with four microRNAs and 20 mRNAs. Patients with high expression of Lnc-SMIM20-1 had poor overall prognosis both in the TCGA adult AML cohort and the TARGET pediatric AML cohort, no matter whether they were treated with chemotherapy or allo-HSCT. No 35894677 lnc-SLC2A12-10:1 LncRNA Homo sapiens Stomach Neoplasms exosomal Expression[highly expressed] qRT-PCR qRT-PCR revealed that lnc-SLC2A12-10:1 was remarkably upregulated in exosomes derived from patients with GC and GCCs. The expression level of exosomal lnc-SLC2A12-10:1 was also significantly correlated with tumor size, TNM stage, lymph node metastasis, and degree of differentiation. No 32494155 lnc-RP11-701H24.7 LncRNA Homo sapiens Arthritis, Psoriatic blood Expression[highly expressed] qRT-PCR//RNA-seq qPCR assay showed that lnc-RP11-701H24.7 and lnc-RNU12 were upregulated in PSA patients compared with NCs, and they could predict PSA risk with high area under curves. No 31390976 lnc-RNU12 LncRNA Homo sapiens Arthritis, Psoriatic blood Expression[highly expressed] qRT-PCR//RNA-seq qPCR assay showed that lnc-RP11-701H24.7 and lnc-RNU12 were upregulated in PSA patients compared with NCs, and they could predict PSA risk with high area under curves. No 31390976 lncRNA-TSIX LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR Compared with the non-malignant groups, the malignant group had higher expression levels of lncRNA-TSIX and SOGA mRNA and a lower expression level of miR-548-a-3p (p < 0.001) in the serum, as depicted in Fig. 1a–c and Table 2. No 31004302 lncRNA-TM1P3 LncRNA Homo sapiens Osteoarthritis articular cartilage Regulation[lncRNA-TM1P3/miR-22/TGF-β signaling/MMP13 axis] qRT-PCR//Western Blot The lncRNA-TM1P3 significantly upregulated in patients with OA, accompanied by the downregulation of miR-22 and upregulation of pSMAD1/5 and MMP13, which ultimately resulted in the degradation of the chondrocyte ECM in patients with OA.These findings demonstrated that the lncRNA-TM1P3/miR-22/TGF-β signaling/MMP13 axis is involved in the degradation of chondrocyte ECM in patients with OA, which could provide novel therapies for OA treatment. No 30887601 MALAT1 LncRNA Homo sapiens Purpura, Thrombocytopenic, Idiopathic blood Expression[highly expressed] qRT-PCR Both lncRNAs MALAT1 and THRIL were significantly upregulated in ITP patients in comparison to HCs ( p < .0001 and = .001 respectively). No 32563217 Lnc-RNA-RP11-510M2 LncRNA Homo sapiens Lung Neoplasms serum exosomal Regulation(RAB27A ) qRT-PCR There was an inverse relationship between expression of serum exosomal RAB27A mRNA and Lnc-RNA-RP11-510M2.10 (r = -0.62, p = .00). Both serum exosomal RAB27A mRNA and Lnc-RNA-RP11-510M2.10 showed a significant positive and negative association with lung cancer patients respectively in comparison to patients with COPD and healthy persons (p < .001). No 32657170 lncRNA-PVT1 LncRNA Homo sapiens Coronary Artery Disease PBMCs of CAD patients Expression(highly expressed) qRT-PCR An increased expression of PVT1 was observed in the untreated PBMCs of CAD patients, compared to the NCAD group. The PVT1 was significantly up-regulated after LPS treatment in the PBMCs of both groups. Plasma MMP-9 levels were found to be higher in CAD patients than in the control individuals. The level of IL-10 and IL-22 production by the non-treated PBMCs of CAD cases was significantly lower than the NCAD group. Overall, in the examined population, PVT1 expression was negatively correlated with IL-10 secretion. Moreover, the results showed a significant negative correlation between PVT1 expression and IL-10 production by untreated cells. No 35103897 lncRNA-PCAT-1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancerous tissues Expression[highly expressed] qRT-PCR Our findings showed that the lncRNA-PCAT-1 gene was up-regulated in cancerous tissues compared with the adjacent non-cancerous tissues (p=0.0016). No 31338011 lncRNA-IGFBP4 LncRNA Homo sapiens Uterine Cervical Neoplasms HeLa cells Regulation(ULK1/Beclin1 signaling) Western Blot//Transfection//Co-IP//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//ChIP We found that serum starvation provokes autophagy-induced downregulation of lncRNA-IGFBP4 levels. Next, we determined that c-Myc can negatively regulate lncRNA-IGFBP4 in HeLa cells. Phenotypically, we found that upon depletion of lncRNA-IGFBP4, the HeLa cells undergo autophagy through ULK1/Beclin1 signaling. No 36072894 lncRNAHELIS LncRNA Homo sapiens Liver Neoplasms 82 paired tissue samples Expression [lower expressed] qRT-PCR We demonstrated that down-regulation of HELIS strongly correlates with carcinogenesis; whereas in tumors with non-hepatocyte origin (HBL, CCA) or in a number of poorly differentiated HCC, this lncRNA is not expressed. No 32918630 LncRNA-GAS5 LncRNA Homo sapiens Recurrent Pregnancy plasma and trophoblasts from 30 patients with RPL and 15 healthy controls. Interaction(miR-140-5p) Flow Cytometry//qRT-PCR//Immunoblotting//Luciferase Report Assay GAS5 was found overexpressed in patients with RPL and positively correlated with the protein levels of TNF-α in the plasma and trophoblasts. Predicted by bioinformatics tools and confirmed by luciferase assay, GAS5 was identified to function as a competing endogenous RNA (ceRNA) binding with miR-140-5p and protects TNF-α expression in HTR-8/SVneo cells and primary trophoblasts. No 33511769 LncRNA-GAS5 LncRNA Homo sapiens Lupus Erythematosus, Systemic PTEN Interaction(miR-21/PTEN signalling) qRT-PCR Also, patients in the SLE group showed a down-regulated expression of LncRNA-GAS5 and PTEN than the healthy volunteers; however, patients with rs145204276 ID/DD genotypes showed up-regulated expression of LncRNA-GAS5 and PTEN compared with patients carrying the II genotype. Thus, we found that the LncRNA-GAS5/miR-21/PTEN signalling pathway was involved in the development of SLE, where LncRNA-GAS5 acted as an miR-21 target, and miR-21 regulated the expression of PTEN. No 33728802 lncRNA-D16366 LncRNA Homo sapiens Carcinoma, Hepatocellular Hepatocellular Carcinoma tissues Expression[lower expressed] qRT-PCR lncRNA-D16366 was proved to be decreased in the tissues and serum among patients with HCC compared with the corresponding controls. Its expression was influenced by tumor size, HbsAg, portal vein tumor thrombus, Child-Pugh score, therapies, and neoplasm metastasis. It had high diagnostic value, with an AUC of 0.752, accompanied by a sensitivity of 65.5% and a specificity of 84.6%. No 31475695 lncRNA-Cox2 LncRNA Homo sapiens Lupus Erythematosus, Systemic Blood samples Expression(highly expressed) qRT-PCR The serum expression levels of lncRNA-Cox2 and HOTAIR were significantly up-regulated in SLE patients vs HCs (fold change [median (IQR) was 1.29(0.81-1.71, P<0.0001) and 2.68(0.95-3.67), P = 0.038) for lncRNA-Cox2 and HOTAIR, respectively. No 35972968 lncRNA-CIR LncRNA Homo sapiens Osteoarthritis cell lines Regulation[lncRNA-CIR/miR-130a/Bim axis] qRT-PCR//Western Blot lncRNA-CIR is significantly upregulated in OA patients, accompanied by downregulation of miR-130a and upregulation of Bim. The present findings demonstrated that the lncRNA-CIR/miR-130a/Bim axis is involved in oxidative stress-related apoptosis of chondrocytes in OA. No 30390341 lncRNA-BANCR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma Expression[Expression[highly expressed]-expression] qRT-PCR The lncRNA-BANCR gene expression alteration was assessed by Real-Time PCR technique. Our findings revealed that lncRNA-BANCR gene expression was increased significantly in tumor tissues compared with the non-cancerous tissues (p = 0.0025). In addition, lncRNA-BANCR gene expression changes was positively associated with the lymph node metastasis (p = 0.013), tumor differentiation (p = 0.019) and tumor stage (p = 0.017). No 30552615 lncRNA-ATB LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines(NCI-H838 and BEAS-2B ) Interaction[MiR-200a/β-Catenin] PCR//Western Blot Compared with normal lung epithelial cells BEAS-2B, NCI-H838 cells had a significantly increased level of lncRNA-ATB (p<0.01), a significantly decreased level of miR-200a (p<0.01) and also a significantly increased level of β-catenin (p<0.01). After knockdown of lncRNA-ATB using si-ATB, the expression level of miR-200a was significantly increased, while that of β-catenin was significantly decreased. Besides, si-ATB remarkably increased the expression of Bcl-2 (p<0.01), and reduced the expressions of cleaved-caspase3 and Cytochrome C (p<0.01) and the apoptosis. In addition, the miR-200a mimic lowered obviously the expression of β-catenin (p<0.05) and reduced apoptosis. No 31983095 lncRNA-ATB LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR Multivariate analysis using the Cox regression test identified that both higher miRNA-21 and higher lncRNA-ATB were independent predictors of mortality and disease progression, along with larger tumor size and higher C-reactive protein (all p < 0.05). NcRNAs were isolated from exosomes using the miRNeasy serum/plasma micro kit. Both circulating exosomal miRNA-21 and lncRNA-ATB were related to TNM stage and other prognostic factors, including the T stage and portal vein thrombosis. Multivariate analysis using the Cox regression test identified that both higher miRNA-21 and higher lncRNA-ATB were independent predictors of mortality and disease progression, along with larger tumor size and higher C-reactive protein (all p < 0.05). The overall survival and progression-free survival were significantly lower in patients with higher circulating levels of exosomal miRNA-21 (≥0.09) and lncRNA-ATB (≥0.0016) (log-rank test: p < 0.05). No 30338850 lncRNA-ATB LncRNA Homo sapiens Hepatitis B plasma Expression [highly expressed] qRT-PCR Results show the plasma levels of lncRNA-ATB in HBV-related cirrhosis patients were significantly higher in comparison to healthy controls (Fold change=2.60, p value=0.04). No 34331990 LncRNA-17A LncRNA Homo sapiens Alzheimer Disease PBMC of AD patients Expression(highly expressed) qRT-PCR The relative LncRNA-17A expression in PBMC of AD patients was evidently higher than that of the control-group (P>0.05). LncRNA-17A expression in PBMC of AD patients with different severity degree had statistical significance (P<0.05); and the relative expression level of LncRNA-17A increased notably with the disease progression (P<0.05). No 34786131 lncRNA-14327.1 LncRNA Homo sapiens Endometrial Neoplasms Interaction[lncRNA-14327.1/Kca3.1] qRT-PCR//MTT//Western Blot Stable expression of lncRNA-14327.1, one of the candidate lncRNAs, led to significant upregulation of Kca3.1 protein level, cell migration and invasion abilities, but suppressed cell proliferation and induced cell cycle arrest. Additionally, our data also demonstrated that Lenti-lncRNA-14327.1 could stabilize the protein of Kca3.1 and subsequently increase intracellular Ca2+ concentration. Transfection of siRNA-Kca3.1 significantly inhibited cell migration and invasion, and attenuated the EMT in Lenti-lncRNA-14327.1 stably expressed endometrial carcinoma cells. No 31819513 lnc-PVT1 LncRNA Homo sapiens Ischemic Stroke 110 patients AIS and 110 controls Expression(highly expressed) qRT-PCR AIS patients had higher Lnc-PVT1 expression compared with that in controls (P < 0.001) with a good supplementary diagnostic value for AIS (area under the curve (AUC) = 0.916 (95%CI 0.881-0.951). Furthermore, Lnc-PVT1 expression was positively linked with NIHSS score (r = 0.380, P < 0.001), IFN-γ (r = 0.217, P = 0.023), TNF-α (r = 0.311, P = 0.001), IL-6 (r = 0.235, P = 0.014), and IL-17A (r = 0.253, P = 0.008), separately. RFS of AIS patients with Lnc-PVT1 quantile 1-2 was higher than that of patients with Lnc-PVT1 quantile 3-4 somehow (P = 0.050). No 34617244 lnc-PVT1 LncRNA Homo sapiens Pancreatitis AP patients Expression(highly expressed) qRT-PCR lnc-PVT1 was overexpressed in AP patients compared with HCs; it was also positively correlated with Ranson's score, acute pathologic and chronic health evaluation II (APACHE II) score, sequential organ failure assessment (SOFA) score, and CRP level in AP patients. lnc-PVT1 was overexpressed in AP patients compared with HCs; it was also positively correlated with Ranson's score, acute pathologic and chronic health evaluation II (APACHE II) score, sequential organ failure assessment (SOFA) score, and CRP level in AP patients. Besides, lnc-PVT1 disclosed a good predictive value for higher in-hospital mortality in AP patients (the area under the curve: 0.838, 95% confidence interval: 0.708-0.968). Lastly, lnc-PVT1 was generally correlated with CRP level as well as SOFA score among mild AP, moderate-severe AP, and SAP subgroups, especially in SAP subgroup; it was also correlated with higher mortality risk in SAP subgroup, but not in mild AP or moderate-severe AP subgroup. No 35108655 lnc-PSCA-4:2 LncRNA Homo sapiens Stomach Neoplasms GC patients Regulation qRT-PCR//Bioinformatics Analysis//Microarray Nine miRNAs and eight lncRNAs were obtained from the microarray analysis. Six miRNAs (miR-550a-5p, miRNA-936, miR-1306-3p, miR-3185, miR-6083, miR-6792-3p) and three lncRNAs (lnc-MB21D1-3:5, lnc-PSCA-4:2 and lnc-ABCC5-2:1) were abnormally expressed in circulating and tissue samples compared with normal control (NC), which was closely related to clinical pathology and survival time of GC patients; circRNA sequencing and qRT-PCR revealed four circRNAs (circASHL2, circCCDC9, circNHSL1 and cirMLLT10) were abnormally expressed in GC tissues and parts of them were negative relationship with their predicted binding miRNAs. No 34295803 lnc-PKD2-2-3 LncRNA Homo sapiens Cholangiocarcinoma cholangiocarcinoma tissues Expression[highly expressed] qRT-PCR//Western Blot//Microarray RT‑qPCR validation revealed that lnc‑PKD2‑2‑3 was Expression[up-expression]regulated in CCA and associated with a higher Eastern Cooperative Oncology GroExpression[up-expression] performance score, poor differentiation, advanced TNM stage, increased carcinoembryonic antigen and poor overall survival in CCA patients. No 31059014 lnc-PFAR LncRNA Homo sapiens Pancreatitis, Chronic PSCs Regulation(pre-miR-141) RNA Pull-Down//Western Blot//qRT-PCR//FISH//Luciferase Report Assay//H&E Staining//IHC//IF Lnc-PFAR facilitates PSCs activation and pancreatic fibrosis via RB1CC1-induced autophagy. Lnc-PFAR reduces miR-141 expression by suppressing pre-miR-141 maturation, which eventually upregulates the RB1CC1 and fibrosis-related indicators expression. Meanwhile, Lnc-PFAR enhanced PSCs activation and pancreatic fibrosis through trigging autophagy. No 34697288 lnc-SNHG16 LncRNA Homo sapiens Sepsis HCs Expression(lower expressed) qRT-PCR lnc-SNHG16 was declined in sepsis patients compared with HCs (p < 0.001). The incidence of ARDS was 27.5% among sepsis patients; meanwhile, sepsis patients with ARDS had higher mortality than those without ARDS (p < 0.001). Furthermore, lnc-SNHG16 was declined in sepsis patients with ARDS compared to those without ARDS (p < 0.001); besides, higher lnc-SNHG16 was independently correlated with declined ARDS occurrence in sepsis patients (p = 0.001), while primary respiratory infection and higher CRP were independently correlated with elevated ARDS occurrence in sepsis patients (both p < 0.05). No 35622463 LNCSRLR LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 LNCV6_107902_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 lnc-ST8SIA4-12 LncRNA Homo sapiens Lung Neoplasms tumor educated platelet Expression(highly expressed) qRT-PCR TEP linc-GTF2H2-1 and RP3-466P17.2 were significantly downregulated, while lnc-ST8SIA4-12 was significantly upregulated in patients with lung cancer or with early-stage lung cancer as compared to healthy donors, possessing AUCs of 0.781, 0.788, 0.725 for lung cancer and 0.704, 0.771, 0.768 for early-stage lung cancer, respectively. No 33792796 LNCV6_107670_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_107495_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_107299_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_107283_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_106802_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_105588_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_105189_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_105044_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_104429_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_104110_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_103078_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_102373_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_102353_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_102197_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_101984_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_101632_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_101515_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_100607_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_100572_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV6_100111_PI430048170 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 LNCV_108266 LncRNA Homo sapiens Colorectal Neoplasms Exosomes from the plasma Expression[highly expressed] qRT-PCR The expression of six lncRNAs (LNCV6_116109, LNCV6_98390, LNCV6_38772, LNCV_108266, LNCV6_84003, and LNCV6_98602) was found to be significantly up-regulated in CRC patients compared with that in healthy individuals by qRT-PCR. No 30562751 lncUEGC1 LncRNA Homo sapiens Stomach Neoplasms stage I GC patients and GCCs Expression [highly expressed] RNA-seq Through combinational analysis of the RNA sequencing results, we found two EGC-specific exosomal lncRNAs, lncUEGC1 and lncUEGC2, which were further confirmed to be remarkably up-regulated in exosomes derived from EGC patients and GCCs. The diagnostic accuracy of exosomal lncUEGC1 was evaluated, and lncUEGC1 exhibited AUC values of 0.8760 and 0.8406 in discriminating EGC patients from healthy individuals and those with premalignant chronic atrophic gastritis, respectively, which was higher than the diagnostic accuracy of carcinoembryonic antigen. No 29690888 Lnc-UCA1 LncRNA Homo sapiens Diabetes, Gestational sixty GDM patients Interaction(miR-138 axis ) qRT-PCR Our present study found that, when compared with healthy pregnancies, the expression levels of Lnc-UCA1 and miR-138 were increased and decreased, respectively, and Lnc-UCA1/miR-138 axis profile was elevated. Second, Lnc-UCA1 and Lnc-UCA1/miR-138 axis were positively correlated with fasting glucose, one-hour glucose, and two-hour glucose, while miR-138 showed the opposite trend. Furthermore, the area under the ROC curve (AUC) were 0.8196, 0.8021, and 0.8901 for diagnostic efficiencies of Lnc-UCA1, miR-138, and Lnc-UCA1/miR-138, respectively. In addition, higher profiles of Lnc-UCA1 were correlated with birth asphyxia of neonate. No 35894480 Lnc-UCA1 LncRNA Mus musculus Myocardial Infarction heart tissues Regulation[miR-143/MDM2/p53 axis] Flow Cytometry//qRT-PCR//Immunoblotting//Luciferase Report Assay The expression of lncUCA1 decreased but miR-143 increased inversely in MI heart.lncUCA1 might protect cardiomyocyte against H/R induced apoptosis by suppressing miR-143 and modulated the following downstream MDM2/p53 signaling pathway, indicating the therapeutic potential of targeting lncUCA1 for MI. No 30998966 lnc-TRIM43B-1 LncRNA Homo sapiens Breast Neoplasms breast cancer samples Expression [lower expressed] Bioinformatics Analysis Expression levels of lnc-MICAL3-2, lnc-DDX31, LINC01063, LINC02381, ENST0000615051 and lnc-TRIM43B-1 were significantly decreased in breast cancer samples compared with paired control tissues (Posterior mean difference= -2.774, -2.012, -2.012, -2.015, -0.884 and -2.872; P values= 0.019, 0.0001, 0.0001, 0.0001, 0.032 and 0.0001, respectively). No 34175685 lnc-TPP2-7:2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 lnc-TMPRSS11BNL-1:2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 lnc-TLN2-4:1 LncRNA Homo sapiens Stomach Neoplasms GC tissue Expression[lower expressed] qRT-PCR Here, we report a novel lncRNA, lnc-TLN2-4:1, whose expression is decreased in GC tissue versus matched normal tissue, and its low expression is involved in the lymph node and distant metastases of GC, as well as poor overall survival rates of GC patients. Here, we report a novel lncRNA, lnc-TLN2-4:1, whose expression is decreased in GC tissue versus matched normal tissue, and its low expression is involved in the lymph node and distant metastases of GC, as well as poor overall survival rates of GC patients. No 32256587 lnc-TCF7 LncRNA Homo sapiens Multiple Myeloma Bone marrow Expression[highly expressed] qRT-PCR Lnc-TCF7 expression was increased in patients with MM compared with HCs. Lnc-TCF7 expression was highest in international staging system (ISS) stage III patients, followed by ISS stage II patients, and then ISS stage I patients, while lnc-TCF7 expression was similar in patients with different immunoglobulin subtypes and Durie-Salmon stages. Regarding chromosomal abnormalities, lnc-TCF7 expression positively correlated with t(4; 14) and Del(17p), whereas no correlation of lnc-TCF7 expression with t(14; 16), 1q21 amplification, Del(13q), or hyperdiploid was observed in patients with MM. No 32578294 NONHSAT159632.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT159828.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 HOTAIR LncRNA Homo sapiens Stomach Neoplasms Regulated[up-regulated] ChIP//Western Blot//CCK8//qRT-PCR//IHC//IF On the whole, the findings of this study suggested that the HOTAIR‑mediated acetylation to methylation switch was associated with the transcriptional inhibition of E‑cadherin. HOTAIR can promote the development of GC through the epigenetic regulation of E‑cadherin, switching the state of the E‑cadherin promoter from the transcriptionally active to the transcriptionally repressive state. No 30431069 TCONS_00212124 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_l2_00000030 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00459923 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00419504 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00387528 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00387527 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00381636 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00362322 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00311313 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00309172 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00268312 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00266158 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00241043 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00241042 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00225423 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00194158 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SOCS3-DT LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).41). No 33330027 TCONS_00147965 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00145366 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00081780 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00079054_HOTAIR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00030845 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00030512 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCONS_00030010 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00029986 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00029766 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[highly expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 TCONS_00029706 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00029632 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00029380 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00028969 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00028585 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[highly expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 TCONS_l2_00000181 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00000382 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00000386 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00000390 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00005718 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00005705 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00005430 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00005388 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00005286 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00004347 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00004216 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00004049 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00003767 LncRNA Homo sapiens Arthritis, Gouty blood Expression[highly expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 TCONS_l2_00003118 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00003063 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00002966 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00002653 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00002490 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00002189 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00002175 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00001787 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00001572 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00001418 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00001211 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00001210 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00000991 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00000977 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00000881 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00000879 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00000663 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00000650 LncRNA Homo sapiens Arthritis, Gouty blood Expression[lower expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 TCONS_l2_00000549 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00000538 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00028490 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00028064 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00027946 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00023756 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00023647 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00023472 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00023347 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[highly expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 TCONS_00023307 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).35). No 33330027 TCONS_00023287 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00023278 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00022974 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00022973 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00022862 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00022374 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00021656 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00021644 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00021543 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00021481 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00021458 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00021430 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00021427 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00021288 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00021287 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00020864 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00020714 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00020456 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00020282 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00020204 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00020168 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00019824 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00019803 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00019802 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00019596 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00023725 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00023880 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00027897 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00023909 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00027754 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00027489 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00027438 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00026839 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[lower expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 TCONS_00026751 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00026568 LncRNA Homo sapiens Arthritis, Gouty blood Expression[highly expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 TCONS_00026525 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00026507 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00026396 LncRNA Homo sapiens Arthritis, Gouty blood Expression[highly expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 TCONS_00026336 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00026233 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00025888 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00025758 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[highly expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 TCONS_00025747 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00025746 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00025744 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00025694 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00025566 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00025565 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00025504 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00025394 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00025309 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00025161 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00025059 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00024772 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00024657 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00024267 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00024238 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00024152 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00006264 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00006336 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00006576 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00018295 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00017984 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00017426 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00017425 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00017422 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00017169 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00017143 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00017141 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00017140 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00017139 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00017138 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00017137 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00017135 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00016801 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00016248 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00016247 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00015963 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00015962 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00015961 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00015960 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00015914 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00015910 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00015862 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00015845 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00015489 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00015482 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00015360 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00015068 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00014965 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00014951 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00018291 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00018668 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00014897 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00018876 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00022961 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00022832 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00022807 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00022724 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00022722 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00022665 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00022345 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00022249 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00022232 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00022059 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00022017 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00022016 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00022010 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00021371 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00021339 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00021337 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00021336 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00021241 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00021053 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00020888 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00020809 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00020420 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00020419 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00019996 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00019995 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00019853 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00019469 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00019087 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00018877 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00014902 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00014895 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00006579 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00009761 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00009522 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00009463 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00009426 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00009425 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00009351 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[highly expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 TCONS_l2_00008734 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00008516 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00008411 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00008410 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00008346 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00008294 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00008237 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00008016 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00007972 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00007970 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00007922 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00007753 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00007568 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00007350 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00007077 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00007053 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00007052 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00007046 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00007045 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00007044 LncRNA Homo sapiens Arthritis, Gouty blood Expression[lower expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 TCONS_l2_00006925 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00006746 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00006745 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00006703 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00009525 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00010129 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00014893 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00010143 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00014890 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00014889 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00014799 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00014790 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00014600 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00014295 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00013986 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00013981 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00013967 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00013897 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00013801 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00013175 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00013067 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00012846 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00012779 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00012428 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00011988 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00011786 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00011785 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00011578 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00011533 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00011248 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00011247 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00011031 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00011027 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00010792 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00010789 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00010596 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00010541 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00019375 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00019151 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00019149 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 T267384 LncRNA Homo sapiens Glaucoma, Open-Angle Aqueous humor Expression[highly expressed] qPCR//Microarray Moreover, real-time quantitative RT-PCR confirmed that T267384, ENST00000607393, and T342877 expression levels were significantly higher in the AH from a different cohort of POAG patients. No 30677397 T234995 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).34). No 33330027 T224378 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).31). No 33330027 T222083 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).8). No 33330027 T216491 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).12). No 33330027 T197170 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).10). No 33330027 T193188 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).26). No 33330027 T186396 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).28). No 33330027 T157700 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).24). No 33330027 T150043 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).21). No 33330027 T133054 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).6). No 33330027 T107545 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).30). No 33330027 T097678 LncRNA Homo sapiens acral lentiginous melanoma tumor and six adjacent non-tumor tissues Expression[highly expressed] qRT-PCR//Microarray The top 5 upregulated lncRNAs were T380070, ENST00000554431, T097678, GSE61474_TCONS_00183926 and NR_015401. No 31966073 T077631 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).22). No 33330027 T067091 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).39). No 33330027 T050410 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).20). No 33330027 T050010 LncRNA Homo sapiens acral lentiginous melanoma tumor and six adjacent non-tumor tissues Expression[lower expressed] qRT-PCR//Microarray The top 5 downregulated lncRNAs were TCONS_00013495, T367528, ENST00000598924, T050010 and TCONS_00010143. No 31966073 T034301 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).19). No 33330027 T030889 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).9). No 33330027 T019592 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).17). No 33330027 T013102 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).40). No 33330027 T004817 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).29). No 33330027 SYNRG-216 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SYNE3 LncRNA Homo sapiens Osteoarthritis OA tissues,cell line Interaction[miR-141] qRT-PCR We have found that lncRNA long intergenic nonprotein coding RNA 341 (LINC00341) is aberrantly downregulated in OA patient tissues and cultured OA chondrocytes. Further investigation has revealed that LINC00341 interacts with miR-141 to suppress its functional binding to the 3'-untranslated region of YY1-associated factor 2 (YAF2) messenger RNA. Aberrant downregulation of LINC00341 thus may ultimately lead to inhibition of the YAF2 protein, which has been implicated to be an antiapoptotic factor. No 30672021 SVIL-AS1-210 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SVIL-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[lower expressed] qRT-PCR//Microarray The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated). No 32020063 SUMO1P3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Interaction[regulating miR-136] qRT-PCR//Luciferase Report Assay//Transwell Assay Then, we confirmed that SUMO1P3 expression was significantly increased in NSCLC cancer tissues and cell lines. Meanwhile, the expression levels of SUMO1P3 expression in metastatic lymph node specimens were strikingly elevated in comparison to primary NSCLC tissue specimens. There was a statistically negative correlation between SUMO1P3 expression and miR-136 expression in NSCLC tissues. Moreover, miR-136 directly bound to SUMO1P3, and SUMO1P3 negatively regulated miR-136 expression in NSCLC cells. Furthermore, SUMO1P3 promoted NSCLC cell migration and invasion via regulating miR-136. Then, we found high SUMO1P3 expression was correlated with late clinical stage, lymph node metastasis, distant metastasis and poor differentiated degree. In the survival analysis of TCGA, we observed that SUMO1P3 expression had no association with overall survival and disease free survival in NSCLC patients. No 30851548 SUMO1P3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Expression(highly expressed) qRT-PCR In this study, we revealed that SUMO1P3 expression was enhanced in HCC tissues and cell lines, positively associating with tumor size and number, poor differentiation, lymphatic and distant metastasis, TNM stage, and poor prognosis in HCC patients. In vitro assays showed that SUMO1P3 depletion reduced HCC cell viability and proliferation by hindering cyclin D1 expression and Akt phosphorylation. SUMO1P3 knockdown induced HCC cell apoptosis, as indicated by increased Bax and cleaved caspase-3 expression and the decreased Bcl-2 level. SUMO1P3 silencing suppressed HCC cell migration and invasion by increasing epithelial marker E-cadherin expression and decreasing mesenchymal marker vimentin expression, as well as reducing matrix metalloproteinase (MMP)-2 and MMP-9 levels. Consistently, SUMO1P3 depletion in HCC cells retarded tumor growth and lung metastasis in vivo. In this study, we revealed that SUMO1P3 expression was enhanced in HCC tissues and cell lines, positively associating with tumor size and number, poor differentiation, lymphatic and distant metastasis, TNM stage, and poor prognosis in HCC patients. No 33902004 SUMO1P3 LncRNA Homo sapiens Triple Negative Breast Neoplasms serum exosomal Expression(highly expressed) qRT-PCR Based on the TCGA data, tissue lncRNA SUMO1P3 was upregulated in BC tissues, and its upregulation was significantly correlated with poor survival. Our findings showed that the expression level of serum exosomal lncRNA SUMO1P3 was significantly higher in patients with TNBC compared to patients with non-TNBC, patients with benign breast disease and healthy controls. Based on the TCGA data, tissue lncRNA SUMO1P3 was upregulated in BC tissues, and its upregulation was significantly correlated with poor survival. In addition, serum exosomal lncRNA SUMO1P3 was closely correlated with lymphovascular invasion, lymph node metastasis and histological grade. No 33506903 SUMF1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 T249502 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).14). No 33330027 T291258 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).4). No 33330027 SUGT1P2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 637 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 T292627 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).5). No 33330027 TC0500000822.mm.1 LncRNA Mus musculus Atherosclerosis aortic tissue Expression[highly expressed] qRT-PCR//Microarray The top fve up-regulated and top fve down-regulated lncR_x0002_NAs are listed in Table 3. No 31446617 TC0500000412.mm.1 LncRNA Mus musculus Atherosclerosis aortic tissue Expression[highly expressed] qRT-PCR//Microarray The top fve up-regulated and top fve down-regulated lncR_x0002_NAs are listed in Table 3. No 31446617 TBRG1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TBILA LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 TBILA LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung serum exosomes Expression[highly expressed] qRT-PCR//Western Blot The two exosomal lncRNA TBILA and AGAP2-AS1 were screened out for the higher levels in NSCLC patients than that of healthy controls in a validation set. And there was a significant positive correlation between these exosomal lncRNAs levels and tumor size, lymph node metastasis and TNM stage. No 32015683 TBCK CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 TBCE CircRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR//circRNA-seq The top 5 up- and downregulated circRNAs in patients with are listed in Table IV. No 32765789 TBC1D3P5 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)54) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 TBC1D22B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TBC1D10C LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TATDN1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Expression[highly expressed] qRT-PCR TATDN1 and TRIM66 was significantly upregulated while miR-451 was downregulated in NSCLC tissues and cell lines, especially in DDP-resistant tumor tissues and cells. No 30481109 TARS3 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 TARID LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TARID LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 996 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 TAPT1-AS1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 750 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 TapSAKI LncRNA Mus musculus Sepsis-Induced Kidney Injury kidney tissue,cell line Regulation[miR-22/PTEN/TLR4/NF-κB pathway] qRT-PCR//RNA Pull-Down//Western Blot TapSAKI was up-regulated, miR-22 was down-regulated, PTEN, TLR4 and p-p65 expressions, and inflammatory factors TNF-α and IL-6 levels were up-regulated in kidney tissue of US rats and LPS-induced HK-2 cells. No 30666657 TALDO1-209 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 TALAM1 LncRNA Homo sapiens Breast Neoplasms cell line Expression[highly expressed] FISH//Wound Healing Assay//qRT-PCR Strand-specific detection of MALAT1 and TALAM1 shown that both lncRNAs are significantly upregulated in all breast cancer cell lines tested comparing to the non-tumorigenic cell line (Fig. ​(Fig.1a1a and Additional file 1: Figure S5). No 31382922 TALAM1 LncRNA Homo sapiens COVID-19 mild and severe COVID-19 patients Regulation Bioinformatics Analysis Interestingly we found six lncRNAs (TALAM1, DLEU2, and UICLM CASC18, SNHG20, and GNAS) involved in the protein-coding DEG-lncRNA network; which might be served as potential biomarkers for COVID-19 patients. No 34975833 TAF8 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 TAF7-202 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TAF6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TACC2-220 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[lower expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 T381125 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).33). No 33330027 T380070 LncRNA Homo sapiens acral lentiginous melanoma tumor and six adjacent non-tumor tissues Expression[highly expressed] qRT-PCR//Microarray The top 5 upregulated lncRNAs were T380070, ENST00000554431, T097678, GSE61474_TCONS_00183926 and NR_015399. No 31966073 T367528 LncRNA Homo sapiens acral lentiginous melanoma tumor and six adjacent non-tumor tissues Expression[lower expressed] qRT-PCR//Microarray The top 5 downregulated lncRNAs were TCONS_00013495, T367528, ENST00000598924, T050010 and TCONS_00010141. No 31966073 T358504 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).13). No 33330027 T342877 LncRNA Homo sapiens Glaucoma, Open-Angle Aqueous humor Expression[highly expressed] qPCR//Microarray Moreover, real-time quantitative RT-PCR confirmed that T267384, ENST00000607393, and T342877 expression levels were significantly higher in the AH from a different cohort of POAG patients. No 30677397 T302937 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).7). No 33330027 SULF1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 STXBP5-AS1 LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 TC0X00002558.mm.1 LncRNA Mus musculus Atherosclerosis aortic tissue Expression[highly expressed] qRT-PCR//Microarray The top fve up-regulated and top fve down-regulated lncR_x0002_NAs are listed in Table 3. No 31446617 SPRY4-IT1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] qRT-PCR SPRY4-IT1 expression was assessed by qRT-PCR in breast cancer tissues and matched normal breast tissues (n=26 pairs).In this study, SPRY4-IT1 was significantly more expressed in cancer tissues than in normal tissues (P<0.05). No 31638266 SPRY4-IT1 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR The levels of serum HULC, MALAT1, Linc00152, PTTG3P, SPRY4-IT1, UBE2CP3, and UCA1 were significantly higher in HCC patients than in patients with benign liver diseases and healthy controls, whereas serum PTENP1 was significantly decreased in HCC patients compared with healthy participants. No 32733618 SPRY4-IT1 LncRNA Homo sapiens Multiple Sclerosis blood Expression[lower expressed] qRT-PCR Relative expressions of SPRY4-IT1, HOXA-AS2, LINC-ROR, and MEG3 were significantly lower in female MS patients compared with female healthy subjects. No 32578033 SPRY4-IT1 LncRNA Homo sapiens Breast Neoplasms female patients Expression(highly expressed) Bioinformatics Analysis The elevated SPRY4-IT1 levels were indicative of poor overall survival (OS) [HR = 2.44, 95% CI = 1.35-4.43, P < .05], and were not related to Disease-Free Survival (DFS) [HR = 1.61, 95% CI = 0.50-5.18, P = .43] in female patients suffering from malignant tumors. The elevated SPRY4-IT1 levels were indicative of poor overall survival (OS) [HR = 2.44, 95% CI = 1.35-4.43, P < .05], and were not related to Disease-Free Survival (DFS) [HR = 1.61, 95% CI = 0.50-5.18, P = .43] in female patients suffering from malignant tumors. No 35482980 SPRY4-IT1 LncRNA Homo sapiens Carcinoma, Ductal, Breast Plasma Expression[highly expressed] qRT-PCR Plasma TINCR, HOTTIP, and SPRY4-IT1 upregulation and ANCR downregulation were observed in SSc patients compared with controls. No 32442909 SPRY4-IT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma esophageal cancer tissues Expression(highly expressed) qRT-PCR The findings revealed that the SPRY4-IT1 expression was significantly higher in esophageal cancer tissues than in adjacent noncancerous tissues. (P < 0.01). Furthermore, the high expression of SPRY4-IT1 was significantly correlated with tumor differentiation (P = 0.029), T classification (P = 0.013), lymph node metastasis(P = 0.022) and pathological stage (P = 0.001). The increased expression of SPRY4-IT1 was associated with a higher risk of cervical and superior mediastinal lymph-node metastasis(P = 0.039). No 33757566 SPRY4-AS1-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SPRR2C LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SPINT1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma Expression[lower expressed] qRT-PCR The expression level (△Ct) of SPINT1-AS1 and SPINT1 mRNA was significantly downregulated in ESCC tissues compared with matched normal tissues (P=0.0005; P=0.0002, respectively), and there was an obvious positive correlation between SPINT1-AS1 and SPINT1 mRNA expression. Clinicopathological characteristics indicated that SPINT1-AS1 expression was correlated with age and tumor size, while SPINT1 mRNA expression was correlated with age and gender. The receiver operating characteristic (ROC) curve analysis of the expression level of SPINT1-AS1 and SPINT1 mRNA yielded an area under the ROC curve value of 0.638 and 0.625, respectively. The overall survival is shorter in patients with low SPINT1-AS1 expressed than those with high levels of SPINT1-AS1 (P=0.044), and SPINT1 mRNA expression level is associated with the OS (P=0.001). Univariate and multivariate analysis suggested that SPINT1-AS1 was an independent prognostic indicator in ESCC. No 31417276 SPIDR-226 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SPIDR CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 SPDYE8 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SPATA8-AS1 LncRNA Homo sapiens Breast Neoplasms serum of BC patients and healthy subjects Expression [highly expressed] RNA-seq After a comprehensive comparison of the BC patients and healthy subjects, we discovered five up-regulated exo-lncRNAs and six down-regulated exo-lncRNAs of interest.  No 34733934 SPATA5L1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SPATA41 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SPATA17-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SPART CircRNA Homo sapiens Stomach Neoplasms blood Expression[lower expressed] qRT-PCR//circRNA-seq The top 5 up- and downregulated circRNAs in patients with are listed in Table IV. No 32765789 SPANXA2-OT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SPAG16 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SPAAR LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Expression[lower expressed] qRT-PCR According to q-RT PCR assay, LINC00961 was downregulated in luminal BC tissues and cell lines. No 33024416 SP3-206 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SOX9-AS1-227 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SOX9-AS1 LncRNA Homo sapiens Cholangiocarcinoma tissues and the cell lines Expression(highly expressed) Transfection//Invasion Assay//Migration Assay//Luciferase Report Assay//Cell Proliferation Assay//Bioinformatics Analysis SOX9-AS1 levels were increased in ICC, both in the tissues and the cell lines. The upregulation of SOX9-AS1 showed a highly discriminative profile, distinguishing ICC patients from healthy subjects or HCC or ECC patients. Upregulation of SOX9-AS1 was related to shorter overall survival and recurrence-free survival. No 35870795 SOX2-OT-278 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SOX2-OT LncRNA Homo sapiens Breast Neoplasms blood Expression[highly expressed] qRT-PCR Our results revealed a significant down-regulation of expression of GAS5 and a significant up_x0002_regulation of SOX2OT expression levels in NSCLC patients when compared to controls . No 31077615 SOX2-OT LncRNA Homo sapiens Breast Neoplasms Breast cancer tissue Expression[highly expressed] qRT-PCR The expression of SOX2OT lncRNA in patients suffering from breast cancer revealed a significant overexpression in comparison with the healthy group (P<0.001). No 32407264 SOX2-OT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung blood Expression[highly expressed] qRT-PCR CCAT1 and SOX2OT were shown to be detectable in the cellular fraction of peripheral human blood, showing serum levels of CCAT1 and SOX2OT were significantly increased of cancer patients as compared to cancer-free controls. No 31933793 SOX2-OT LncRNA Homo sapiens lung squamous cell carcinoma exosomes Expression[highly expressed] qRT-PCR Exosomal SOX2-OT was significantly upregulated in LSCC patients and showed the strongest power in detecting LSCC. The area under the ROC curve was 0.815, and the sensitivity and specificity were 76% and 73.17%, respectively. Moreover, exosomal SOX2-OT levels were significantly correlated with tumor size, TNM stage, and lymph node metastasis. No 30986097 SOX2-OT LncRNA Homo sapiens Abortion, Habitual blood Mutation[rs9839776 ] Genotyping However, whether lncRNA SOX2OT polymorphisms are related to recurrent miscarriage susceptibility is unclear. Therefore, we investigated the relationship between the lncRNA SOX2OT rs9839776 C>T polymorphism and recurrent miscarriage susceptibility. We recruited 570 subjects with recurrent miscarriage and 578 healthy control subjects from a population in southern China and used the TaqMan method for genotyping. We found a significant association between the rs9839776 CT genotype in the SOX2OT gene and an increased risk for recurrent miscarriage (CT vs CC: adjusted OR = 1.357, 95%CI = 1.065 - 1.728, P = 0.0134). However, we did not observe any significant associations between the recurrent miscarriage risk and the number of miscarriages in different age groups. In conclusion, our study indicated that the rs9839776 CT genotype may contribute to an increased risk of recurrent miscarriage in the southern Chinese population and that rs9839776 may act as a prognostic biomarker in recurrent miscarriage patients. However, an experiment-based study with a larger sample size should be performed to confirm these results. No 31827385 SOX21-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cancer tissues Epigenetics(methylation) qRT-PCR//Bioinformatics Analysis The expression levels of SOX21-AS1 and SOX21 were noted to be higher in cancer vs. normal cervix (all P < 0.001). Moreover, the expression of SOX21-AS1 was positively correlated with SOX21 in all samples (r = 0.891, P < 0.001). Methylation statue of the SOX21-AS1 promoter region was negatively correlated with the expression levels of SOX21-AS1 and SOX21 (SOX21-AS1, r = - 0.628; SOX21, r = - 0.648; both P < 0.001). The methylation status of SOX21-AS1 displayed promising diagnostic potential for CC, exhibiting good sensitivity (100.0%) and specificity (69.2%), with an area under the curve of 0.846. In addition, bioinformatic analyses identified a potential link between SOX21-AS1 and the Wnt signaling pathway. The methylation status of SOX21-AS1 displayed promising diagnostic potential for CC, exhibiting good sensitivity (100.0%) and specificity (69.2%), with an area under the curve of 0.846. No 33095426 SPRY4-IT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells interaction[ targeting PDK1] qRT-PCR//MTT//RIP Herein, we found the high level of SPRY4-IT1 in human colorectal cancer (CRC) tissues and cells, and correlated with patients' prognosis.Our data further confirmed that SPRY4-IT1 regulated CRC progression targeting PDK1. Herein, we found the high level of SPRY4-IT1 in human colorectal cancer (CRC) tissues and cells, and correlated with patients' prognosis. No 33029299 SPRY4-IT1 LncRNA Homo sapiens Breast Neoplasms Primary cancer tissues and paired adjacent noncancerous tissues Expression[highly expressed] qRT-PCR " As shown in Figure 1, the results showed that the relative expression of SPRY4-IT1 was significantly higher in BC tissues than in normal breast tissues (P < 0.001). " Furthermore, the SPRY4-IT1 level was significantly associated with tumor size (P = 0.009), TNM stage (P = 0.0008) and lymph node metastasis (P = 0.01). Using a Kaplan-Meier analysis, it was shown that patients with high SPRY4-IT1 expression had a significantly poor overall survival (OS) rate (P = 0.0056) and a disease-free survival (DFS) rate (P = 0.0001). Moreover, multivariate Cox analysis revealed that SPRY4-IT1 expression was an independent poor prognostic factor for both OS (P = 0.024) and DFS (P = 0.025) in BC patients. No 31933911 STRADB-210 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 SPTBN1-204 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 STK38L-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 STEAP3-AS1 LncRNA Homo sapiens Colorectal Neoplasms clinical CRC tissues Regulation(STEAP3-AS1/STEAP3/Wnt/β-catenin axis) ISH//qRT-PCR//RIP//FISH Here, we identified a hypoxia-induced antisense lncRNA STEAP3-AS1 that was highly expressed in clinical CRC tissues and positively correlated with poor prognosis of CRC patients. Upregulation of lncRNA STEAP3-AS1, which was induced by HIF-1α-mediated transcriptional activation, facilitated the proliferation and metastasis of CRC cells both in vitro and in vivo. Mechanistically, STEAP3-AS1 interacted competitively with the YTH domain-containing family protein 2 (YTHDF2), a N6-methyladenosine (m6A) reader, leading to the disassociation of YTHDF2 with STEAP3 mRNA. This effect protected STEAP3 mRNA from m6A-mediated degradation, enabling the high expression of STEAP3 protein and subsequent production of cellular ferrous iron (Fe2+). Increased Fe2+ levels elevated Ser 9 phosphorylation of glycogen synthase kinase 3 beta (GSK3β) and inhibited its kinase activity, thus releasing β-catenin for nuclear translocation and subsequent activation of Wnt signaling to support CRC progression. Here, we identified a hypoxia-induced antisense lncRNA STEAP3-AS1 that was highly expressed in clinical CRC tissues and positively correlated with poor prognosis of CRC patients. No 35986274 STAT1 LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-27A) Expression[lower expressed] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD21 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 STARD4-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 STARD13-AS LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[lower expressed] ISH//qRT-PCR//Microarray By microarray assessment, lncRNA STARD13-AS was significantly down-regulated in tumor tissues. Compared with non-tumor tissues, using both RT-qPCR and ISH assay, STARD13-AS expression was significantly depressed in GC tissues (p < 0.01, respectively) and was closely correlated with tumor stage and histological grade (p < 0.05, respectively), but was not correlated with gender, age, tumor size, tumor location or lymph node metastasis. The 5-year overall survival and progression free survival rates of the low lncRNA STARD13-AS expression group were significantly down-regulated compared with those of the high lncRNA STARD13-AS expression group (p < 0.001, respectively). No 32902230 ST8SIA6-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular blood,cell lines Expression[highly expressed] qRT-PCR Our data demonstrated an up-regulation of ST8SIA6-AS1 in 77 HCC patients and HCC cell lines. Besides, clinicopathological analysis revealed that ST8SIA6-AS1 corresponds with tumor stages and metastasis, thus might be used for monitoring the HCC progress. No 33337846 ST7-OT4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ST7-OT4 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 641 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ST7L-219 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ST7-AS1 LncRNA Homo sapiens Breast Neoplasms BRC tissues Expression(lower expressed) qRT-PCR LncRNA ST7-AS1 expression was downregulated in BRC. Decreased lncRNA ST7-AS1 expression in BRC was correlated with advanced clinical pathologic characteristics (high grade, histological type, age, menopause status, and HER2 status), survival time, and poor prognosis. No 33912584 ST6GALNAC1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ST6GAL2-IT1 LncRNA Homo sapiens Myelodysplastic Syndromes bone marrow Expression[lower expressed] qRT-PCR//Microarray Of the functionally described lncRNAs, we detected the upregulation of H19, EMCN-IT1, WT1-AS, MEG8, and PVT1 and the downregulation of ST6GAL2-IT1 and U8. No 32977510 ST3GAL6-AS1-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ST3GAL6-AS1 LncRNA Homo sapiens Multiple Myeloma Bone Marrow Expression[highly expressed] qRT-PCR qRT-PCR was performed to verify the 4 most significantly upregulated lncRNAs in 20 MM cases and 10 IDA cases. NR_046683 was most significantly upregulated (Figure 1B), so the expression of lncRNA NR_046683 was further detected in 66 MM patients (Figure 1C). No 30766487 ST3GAL6-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD patients and LUAD cell Interaction(ST3GAL6/ EGFR signaling) Western Blot//qRT-PCR//Microarray//IHC//Transwell Assay Additionally, the ST3GAL6 level was positively regulated by ST3GAL6-AS1, an antisense long non-coding RNA to its host gene. The downregulation of ST3GAL6-AS1 also heralds a worse prognosis in LUAD patients and promotes LUAD cell invasiveness, recapitulating the function of its host gene, ST3GAL6. Altogether, ST3GAL6-AS1-regulated ST3GAL6 is a frequently downregulated sialyltransferase in LUAD patients and negatively regulates EGFR signaling, which can serve as a promising independent prognostic marker in LUAD patients. The downregulation of ST3GAL6-AS1 also heralds a worse prognosis in LUAD patients and promotes LUAD cell invasiveness, recapitulating the function of its host gene, ST3GAL6. No 36092699 ST20 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Expression[highly expressed] qRT-PCR Microarray analysis identified 1850 lncRNAs with significant differential expression in ESCC. Of 22 lncRNAs selected for quantitative reverse transcription PCR verification, four were significantly upregulated and one was significantly downregulated in ESCC cancer compared to para-cancer tissues. ENST00000508406.1 was significantly associated with T, N, and tumor node metastasis stages, and NR_037652.1 was significantly associated with N stage. Moreover, 50 lncRNA-messenger RNA pairs were significantly associated with the two dysregulated lncRNAs and possibly involved in the regulation of local invasion and lymphatic metastasis of ESCC. ENST00000508406.1 was significantly associated with T, N, and tumor node metastasis stages, and NR_037652.1 was significantly associated with N stage. No 30390388 ST20 LncRNA Homo sapiens Cardiovascular Diseases blood Expression[highly expressed] qRT-PCR//Microarray To validate the microarray data, four up-regulated lncRNAs (NR_037652.1, ENST00000607654.1, ENST00000589524.1 and uc004bhb.3) were selected based on the functional co-expression networks, the signal value and the validation of designed primers. A description of the four strictly screened lncRNAs is presented in Table 5. The four lncRNAs were all up-regulated between 50 Uyghur SAP patients and 50 matched controls, which were consistent with the microarray data (Figure 8). The characteristics of the 100 validated participants are shown in Table 6. For an in-depth understanding of the four lncRNAs, the target genes are mainly based on correlation of at least 0.8, not only the possible function (Supplementary Figure S1). No 31413167 SSTR5-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR We observed that SSTR5-AS1 expression was highly expressed in GC specimens compared with adjacent non-tumor specimens (p < 0.01). High SSTR5-AS1 expression was correlated with an advanced pathologic stage. No 32495873 SSTR5-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SSBP3-AS1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)111) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 SRSF8 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SRSF3-207 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 SRSF1-202 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 SRSF11-206 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 SRRM4-202 LncRNA Homo sapiens Adrenocortical Carcinoma ACC tissues Expression[highly expressed] qRT-PCR//Microarray In these samples, 874 lncRNAs were differentially expressed in ACC compared with NAC, of which 409 were upregulated, and 465 were downregulated. The 874 differentially expressed lncRNAs corresponded to 330 annotated lncRNA genes. Among the upregulated lncRNAs, the greatest log2 fold change was 8.5 for an unannotated lncRNA gene, and RAD50 was the geratest upregulated, annotated lncRNA gene with a log2 fold change of 6.1. Among the downregulated lncRNAs, the greatest log2 fold change was 8.3 for an unannotated lncRNA gene and 6.4 for HAND2, the greatest downregulated annotated lncRNA gene; of these, 183 differently expressed lncRNAs had established functions in cancer development and cancer progression. Selected carcinogenesis-related lncRNAs are summarized in Table 2. No 31522749 SRP14-DT LncRNA Homo sapiens Dissection, Thoracic Aorta Human TAD (n=3) and normal aortic tissues (NA) (n=3) Expression [highly expressed] qRT-PCR//RNA-seq//Bioinformatics Analysis QRT-PCR results of five dysregulated genes were consistent with HTS data. A lncRNA-mRNA coexpression analysis showed positive correlations between the up-regulated lncRNA (ENSG00000269936) and its adjacent up-regulated mRNA (MAP2K6, R=0.940, P< 0.01), and between the down-regulated lncRNA_1421 and its down-regulated mRNAs (FBLN5, R=0.950, P< 0.01; ACTA2, R=0.96, P< 0.01; TIMP3, R=0.96, P< 0.05). The lncRNA-miRNA-mRNA network indicated that the up-regulated lncRNA XIST and p21 had similar sequences targeted by has-miR-17-5p. The results of luciferase assay and fluorescence immuno-cytochemistry were consistent with that. And qRT-PCR results showed that lncRNA XIST and p21 were expressed at a higher level and has-miR-17-5p was expressed at a lower level in TAD than in NA. The predicted binding motifs of three up-regulated lncRNAs (ENSG00000248508, ENSG00000226530, and EG00000259719) were correlated with up-regulated RUNX1 (R=0.982, P< 0.001; R=0.967, P< 0.01; R=0.960, P< 0.01, respectively). No 29669321 SREBF2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SRA1 LncRNA Homo sapiens Mucocutaneous Lymph Node Syndrome serum Regulation qRT-PCR The results indicated that the serum levels of lncRNAs SRA and HCG22 were higher in patients with acute KD compared with those in healthy controls. B-type natriuretic peptide (BNP) and C-reactive protein were positively correlated with HCG22 in patients with acute KD, while total cholesterol and low-density lipoprotein were negatively correlated with HCG22 in patients with acute KD. No 34373708 SPTBN1-205 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 TC0600002382.mm.1 LncRNA Mus musculus Atherosclerosis aortic tissue Expression[lower expressed] qRT-PCR//Microarray The top fve up-regulated and top fve down-regulated lncR_x0002_NAs are listed in Table 3. No 31446617 TC1400000740.mm.1 LncRNA Mus musculus Atherosclerosis aortic tissue Expression[highly expressed] qRT-PCR//Microarray The top fve up-regulated and top fve down-regulated lncR_x0002_NAs are listed in Table 3. No 31446617 TCONS_00019138 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00012614 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00012377 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00012258 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00012018 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00011803 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00011457 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00011403 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00011243 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00011242 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00011165 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[highly expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 TCONS_00011145 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00011115 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00010795 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00010793 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00010744 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00010576 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00010403 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00010140 LncRNA Homo sapiens acral lentiginous melanoma tumor and six adjacent non-tumor tissues Expression[lower expressed] qRT-PCR//Microarray The top 5 downregulated lncRNAs were TCONS_00013495, T367528, ENST00000598924, T050010 and TCONS_00010144. No 31966073 TCONS_00010097 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00010018 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00009732 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00009526 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00009333 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00009252 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00008880 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00008681 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00008673 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00008645 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00008572 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[lower expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 TCONS_00008571 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[lower expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 TCONS_00012383 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).32). No 33330027 TCONS_00012828 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00008546 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00012830 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00019135 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00018733-XLOC_008489 LncRNA Homo sapiens Brain Injuries, Traumatic Brain tissues Expression[lower expressed] qRT-PCR//Microarray LncRNA and mRNA expression profiles were detected in three TBI and three control groups. Volcano plot filtering identified 99 differentially expressed lncRNAs (P < 0.05, fold change > 1.2) (Figure ​1A1A and ​andB).B). Among them, 43 lncRNAs were up-regulated and 56 lncRNAs were down-regulated. In the TBI group, n333955, n332943, n335470, ENST00000384390, and n341115 were the five most significantly up-regulated lncRNAs. While, TCONS_00018733-XLOC_008489, OTTHUMT00000076953, NR_029967, ENST00000433249, and n381234 were the five most significantly down-regulated lncRNAs (Table 3). Next, we compared mRNA expression profiles of the TBI group with the control group. No 30632503 TCONS_00018683 LncRNA Homo sapiens Arthritis, Gouty blood Expression[highly expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 TCONS_00018640 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[lower expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 TCONS_00018625 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00018450 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00018337 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00017726 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00017673 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00017539 LncRNA Homo sapiens Diabetes Mellitus, Type 2 five patients with T2D and paired controls Expression(lower expressed) qRT-PCR//Bioinformatics Analysis//Microarray The top five upregulated lncRNAs are ENST00000381108.3, ENST00000515544.1, ENST00000539543.1, ENST00000508174.1, and ENST00000564527.1, and the top five downregulated lncRNAs are TCONS_00017539, ENST00000430816.1, ENST00000533203.1, ENST00000609522.1, and ENST00000417079.1. No 35257412 TCONS_00017253 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00017068 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00016890 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00016844 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00016443 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00016354 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00016338 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00016315 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00015719 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00015680 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00015353 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00015109 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00014543 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00014248 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00013495 LncRNA Homo sapiens acral lentiginous melanoma tumor and six adjacent non-tumor tissues Expression[lower expressed] qRT-PCR//Microarray The top 5 downregulated lncRNAs were TCONS_00013495, T367528, ENST00000598924, T050010 and TCONS_00010140. No 31966073 TCONS_00013117 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00013092 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00013018 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00012947 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00008555 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00008143 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TC1500001682.mm.1 LncRNA Mus musculus Atherosclerosis aortic tissue Expression[lower expressed] qRT-PCR//Microarray The top fve up-regulated and top fve down-regulated lncR_x0002_NAs are listed in Table 3. No 31446617 TCONS_00003167 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00002977 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00002763 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00002573 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00002052 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00002051 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00001982 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00001891 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00001838 LncRNA Homo sapiens Tuberculosis host peripheral blood Regulation PCR "LncRNAs TCONS_00001838 and n406498 have the potential to become new molecular markers for PTB, and the nomogram of ""LncRNA + EHR"" model is expected to be effective for the early clinical diagnosis of TB." "Furthermore, the nomogram showed good compliance in predicting the risk of TB and a higher net benefit than the ""EHR"" model for threshold probabilities of 0.2-1." No 35308365 TCONS_00001651 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00001511 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00001459 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00000764 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00000640 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00000531 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00000111 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00000054 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCLlnc1 LncRNA Homo sapiens Stomach Neoplasms plasma and tissue samples Expression(highly expressed) qRT-PCR Plasma TCLlnc1 was also increased in gastric cancer. Plasma TCLlnc1 was closely correlated with TCLlnc1 in gastric cancer tissues, but not TCLlnc1 in nontumor tissues. TCLlnc1 in plasma was only correlated with tumor distant metastasis, but not other clinical data. TCLlnc1 in plasma showed promising diagnostic value for stage I and II gastric cancer. Increased accumulation of TCLlnc1 was closely correlated with distant recurrence and poor survival during a 5-year follow-up. Increased accumulation of TCLlnc1 was closely correlated with distant recurrence and poor survival during a 5-year follow-up. No 36066396 TCL6 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)66) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 TCF7L2 LncRNA Homo sapiens Diabetes Mellitus, Type 2 Sixty individuals Mutation(rs7903146) Genotyping TCF7L2 rs7903146, CASC8 rs6983267 and GREM1 rs16969681 could be risk factors for the association of T2DM with CRC. No 35893034 TCF21 LncRNA Homo sapiens Coronary Artery Disease Serum Expression(highly expressed) qRT-PCR he serum level of CCHE1 was positively related to CAD severity and numbers of vessel lesions, while TCF21 displayed a negative relationship. During the 3-year follow-up, the incidence of cardiovascular events was 39.3% (59/150). CAD severity, numbers of vessel lesions, and serum levels of CCHE1 and TCF21 were independent factors influencing the occurrence of cardiovascular events in CAD patients. The serum level of CCHE1 was positively related to CAD severity and numbers of vessel lesions, while TCF21 displayed a negative relationship. During the 3-year follow-up, the incidence of cardiovascular events was 39.3% (59/150). CAD severity, numbers of vessel lesions, and serum levels of CCHE1 and TCF21 were independent factors influencing the occurrence of cardiovascular events in CAD patients. No 34970358 TCERG1-215 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TCEAL1 LncRNA Homo sapiens Rectal Neoplasms Rectal Cancer tissues Expression[lower expressed] qRT-PCR LincRNA-p21 was downregulated in tumor versus normal tissue (p = 0.0012). CRC patients with high lincRNA-p21 expression had shorter DFS (p = 0.0372) and shorter OS (p = 0.0465). Of note, the major prognostic impact was observed in the subset of rectal cancer patients where patients with high lincRNA-p21 levels had worse DFS (p = 0.0226) and OS (p = 0.0457). Interestingly, rectal cancer patients with high lincRNA-p21 benefited from post-operative chemoradiotherapy, as indicated by a longer OS in the group of high lincRNA-p21 patients receiving post-operative chemoradiotherapy (p = 0.04). Finally, patients with high lincRNA-p21 levels in mesenteric vein (MV) had shorter OS (p = 0.0329). No 32878005 TCEA2-214 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 TCEA1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCAM1P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TC1700001922.mm.1 LncRNA Mus musculus Atherosclerosis aortic tissue Expression[lower expressed] qRT-PCR//Microarray The top fve up-regulated and top fve down-regulated lncR_x0002_NAs are listed in Table 3. No 31446617 TC1700000139.mm.1 LncRNA Mus musculus Atherosclerosis aortic tissue Expression[highly expressed] qRT-PCR//Microarray The top fve up-regulated and top fve down-regulated lncR_x0002_NAs are listed in Table 3. No 31446617 TC1500001722.mm.1 LncRNA Mus musculus Atherosclerosis aortic tissue Expression[lower expressed] qRT-PCR//Microarray The top fve up-regulated and top fve down-regulated lncR_x0002_NAs are listed in Table 3. No 31446617 TCONS_00002978 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00003330 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00007979 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00003359 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00007922 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00007915 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00007778 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00007771 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00007669 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00006823 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00006822 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00006821 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00006820 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00006729 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00006572 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00006403 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00006356 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00006172 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00006171 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00006004 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00005818 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00005490 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00005441 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00005387 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[lower expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 TCONS_00004989 LncRNA Homo sapiens allergic asthma peripheral blood mononuclear cells Regulation qPCR ENST00000499459 and TCONS_00004989 are potential biomarkers for house dust mite-induced allergic asthma. No 36463267 TCONS_00004742 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00004564 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00004563 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00004187 LncRNA Homo sapiens Diabetes Mellitus, Type 2 blood Expression[lower expressed] qRT-PCR//Microarray Compared with the control group, the expression levels of the GCKR gene and lncRNA ENST00000588707.1 and TCONS_00004187 in the T2DM group were significantly lower (P < 0.05). The correlation analysis revealed that ENST00000588707.1 and TCONS_00004187 were correlated with GCKR gene expression and glycolipid metabolism (P < 0.05). ROC analysis showed that the area under the curve value of ENST00000588707.1 between T2DM patients and non-T2DM patients was 0.816 (95% CI: 0.764-0.869, sensitivity 72.0%, specificity 80.3%) and the AUC value of TCONS_00004187 was 0.826 (95% CI: 0.774-0.879, sensitivity 81.6%, specificity 61.3%). No 31756311 TCONS_00003910 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00003872 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_00003609 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[lower expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 TCONS_00003475 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00023999 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00024007 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00024305 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 WAC-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 VTRNA2-1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 VRK1 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[lower expressed] qRT-PCR Circ-VRK1 was downregulated in breast cancer tissues compared with adjacent tissues and represented a good value in distinguishing breast cancer tissues from the adjacent tissues. Circ-VRK1 was associated with smaller tumour size, reduced T stage and lower TNM stage, and circ-VRK1 was also an independent predictor of better overall survival. No 31970831 VPS9D1-AS1 LncRNA Homo sapiens Colorectal Neoplasms 500 CRC patients and 500 healthy individuals Mutation(rs7206570) qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis Quantitative real-time PCR technology was used to detect the expression of VPS9D1-AS1 and hsa-miR-361-3p in colorectal tissues with different rs7206570 genotypes. The dual-luciferase reporter assay was used to examine whether the rs7206570 polymorphism affects hsa-miR-361-3p binding. CRC patients with rs7206570 A allele were less likely to have high-stage CRC. Furthermore, there was a significant negative correlation between the expression of VPS9D1-AS1 and hsa-miR-361-3p in CRC tissues with rs7206570 GG genotype. Dual-luciferase reporter assay showed that the rs7206570 A allele presumably hinders the binding of VPS9D1-AS1 to hsa-miR-361-3p. The rs7206570 polymorphism was not associated with CRC risk, but was associated with the clinical stage of CRC. No 35022999 VPS13B CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 VIM-AS1 LncRNA Homo sapiens Breast Neoplasms serum of BC patients and healthy subjects Expression [highly expressed] RNA-seq After a comprehensive comparison of the BC patients and healthy subjects, we discovered five up-regulated exo-lncRNAs and six down-regulated exo-lncRNAs of interest. No 34733934 VDR LncRNA Homo sapiens COVID-19 peripheral blood Expression(lower expressed) qRT-PCR Expression of SNHG6 was considerably lower in COVID-19 patients compared with control subjects (Ratio of mean expression (RME) = 0.22, P value = 7.04E-05) and in both female and male COVID-19 patients compared with sex-matched unaffected individuals (RME = 0.32, P value = 0.04 and RME = 0.16, P value = 0.000679683, respectively). However, its expression was similar among ICU-hospitalized and non-ICU patients. Similarly, expression of SNHG16 was lower in in COVID-19 patients compared with controls (RME = 0.20, P value = 5.94E-05) and in both female and male patients compared with sex-matched controls (RME = 0.32, P value = 0.04 and RME = 0.14, P value = 0.000496435, respectively) with no significant difference among ICU-hospitalized and non-ICU hospitalized patients. Expression of VDR was lower in COVID-19 patients compared with controls (RME = 0.42, P value = 0.04) and in male patients compared with male controls (RME = 0.27, P value = 0.02). Yet, expression of VDR was statistically similar between female subgroups and between ICU-hospitalized and non-ICU hospitalized patients. Expression levels CYP27B, Linc00511 and Linc00346 were similar among COVID-19 patients and healthy subjects or between their subgroups. Significant correlations have been detected between expression levels of VDR, CYP27B and SNHG6, SNHG16, Linc00511 and Linc00346 lncRNAs both among COVID-19 patients and among healthy controls with the most significant ones being SNHG6 and SNHG16 (r = 0.74, P value = 3.26e-17 and r = 0.81, P = 1.54e-22, respectively). No 34147082 VDAC2P2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] qRT-PCR//RNA-seq Among the 557 lncRNAs, 30 and 962 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 VDAC1P8 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 951 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 VCAN-AS1-202 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[highly expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 VAPB CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 UXS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 UTRN CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 USP6NL LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 USP3-AS1 LncRNA Homo sapiens Neuroblastoma Neuroblastoma tissues Expression[lower expressed] ChIP-seq//RNA-seq Differential analysis revealed nine significantly differentially expressed (more than 2-fold change with corrected p-value) lncRNAs between tumor cells and matched MNCs. Of these, RFPL1S (p = 0.0001), PPP1R26-AS1 (p = 0.03), RP11-439E19.3 (p = 1.24 × 10–6), CASC15 (p = 1.6 × 10–7), AC004540.5 (p = 0.0002), and CTD-2881E23.2 (p = 1.6 × 10–9) were found to be significantly Expression[up-expression]regulated (Figure 1B), while USP3-AS1 (p = 1.78 × 10–6), CHRM3-AS2 (p = 0.003) and RP6-99M1.2 (p = 0.002) were significantly downregulated (Figure 1C). No 31920530 USP32P2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 USP32P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 USP30-AS1 LncRNA Homo sapiens Breast Neoplasms TCGA and breast cancer cells Expression [highly expressed] qRT-PCR The qRT-PCR identified 5 lncRNAs with significantly differential expression in breast cancer cells based on the 9 lncRNAs of the prognostic model, and the results were consistent with the tissues. In order to further explore the prognostic value of the 9 lncRNAs, the Kaplan Meier curve was built to confirm the relationship between these lncRNAs and OS. In our analysis, a total of 6 of the 9 lncRNAs (USP30-AS1, ST7-AS1, VPS9D1-AS1, OTUB6DB-AS1, LINC01087, and MAPT-AS1) were identified. The results indicated that the 6 autophagy-related lncRNAs were correlated to the OS in breast cancer patients No 33614483 USP15 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 USF2-206 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 USF1-204 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 UQCRC2-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 UNGP3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 753 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 UNC79 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 UNC5B-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells regulation[sponge miR-107 to upregulate oncogenic CDK8] qRT-PCR//Luciferase Report Assay It was observed that UASR1 is upregulated in CRC and its high expression levels predicted poor survival in patients with CRC.Therefore, UASR1 may sponge miR-107 to upregulate oncogenic CDK8, thereby promoting CRC cell proliferation. It was observed that UASR1 is upregulated in CRC and its high expression levels predicted poor survival in patients with CRC. No 33093914 ULK3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 UIMC1-214 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 UICLM LncRNA Homo sapiens COVID-19 mild and severe COVID-19 patients Regulation Bioinformatics Analysis Interestingly we found six lncRNAs (TALAM1, DLEU2, and UICLM CASC18, SNHG20, and GNAS) involved in the protein-coding DEG-lncRNA network; which might be served as potential biomarkers for COVID-19 patients. No 34975833 UGP2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)5) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 VWFP1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 899 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 WBP2-207 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 UGGT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 WBP2-209 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 XIST LncRNA Homo sapiens Retinoblastoma RB tissues and cell lines Expression[highly expressed] qRT-PCR//Luciferase Report Assay Our data indicated that XIST was highly expressed in RB tissues and cell lines. No 32329826 XIST LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues, cell lines Expression[highly expressed] qRT-PCR The results showed that lncRNA XIST was upregulated in OSCC tissues, cell lines, and CDDP-resistant OSCC cells. No 33191714 XIST LncRNA Homo sapiens Aortic Aneurysm, Thoracic blood of TAA patients. Interaction(miR-193a-5p/KLF7 axis) Other XIST was found to be the most overexpressed lncRNA among predicted lncRNAs binding to miR-193a-5p. Subsequently, KLF7 was proved to be the downstream factor of the XIST/miR-193a-5p axis. Rescue assays testified the whole regulation mechanism of the XIST/miR-193a-5p/KLF7 axis in TAA. MiR-193a-5p was absorbed by XIST for the improvement of KLF7 in TAA. No 36495497 XIST LncRNA Homo sapiens Breast Neoplasms Serum samples Expression(highly expressed) qRT-PCR Assessment of lncRNA XIST, and lncRNA NEAT1 expression was performed using real time PCR. Expression levels of the investigated lncRNAs were significantly higher in BC patients as compared to the other groups. Both lncRNAs were significantly correlated with BC laterality, lymph node involvement, and clinical stages. No 33602501 XIST LncRNA Homo sapiens Tuberculosis MTB models Interaction(lncRNA XIST/microRNA-125b-5p/A20/NF-κB axis) In Vivo Experiment The MTB models were characterized by upregulated XIST and downregulated miR-125b-5p. XIST bound to miR-125b-5p, leading to its downregulation, and thus causing higher MTB survival in an ESAT-6-dependent manner. Additionally, negative pressure treatment decreased MTB-driven XIST expression through downregulation of A20 (an NF-κB repressor) via miR-125b-5 expression, promoting the M1 polarization program in macrophages through activation of the NF-κB pathway. No 35579934 XIST LncRNA Homo sapiens Liver Cirrhosis, Biliary NKs and CD4+ T cells Expression(highly expressed) Transfection//Flow Cytometry//FISH//CCK8//qRT-PCR The expression levels of LncRNA XIST in NKs and CD4+ T cells in PBC patients were significantly higher than those in HC, and were primarily located at the nucleus. LncRNA XIST could promote the proliferation of naive CD4+ T cells. When naive CD4+ T cells were co-cultured with BECs, the expressions of IFN-γ, IL-17, T-bet and RORγt in naive CD4+ T cells were decreased. No 35309298 XIST LncRNA Homo sapiens Coronary Artery Disease CAD patients Expression(highly expressed) qPCR MALAT1 and MIAT were upregulated in CAD patients (p Value= .0008 and .0078, respectively). The expression level of XIST was significantly elevated diabetic compared to non-diabetic CAD patients (p Value= .0003). MALAT1 gene had the highest diagnostic power for discrimination of CAD patients from controls (AUC= 0.682, p Value=.001). No 32447981 XIST LncRNA Homo sapiens Dissection, Thoracic Aorta Human TAD (n=3) and normal aortic tissues (NA) (n=3) Expression [highly expressed] qRT-PCR//RNA-seq//Bioinformatics Analysis QRT-PCR results of five dysregulated genes were consistent with HTS data. A lncRNA-mRNA coexpression analysis showed positive correlations between the up-regulated lncRNA (ENSG00000269936) and its adjacent up-regulated mRNA (MAP2K6, R=0.940, P< 0.01), and between the down-regulated lncRNA_1421 and its down-regulated mRNAs (FBLN5, R=0.950, P< 0.01; ACTA2, R=0.96, P< 0.01; TIMP3, R=0.96, P< 0.05). The lncRNA-miRNA-mRNA network indicated that the up-regulated lncRNA XIST and p21 had similar sequences targeted by has-miR-17-5p. The results of luciferase assay and fluorescence immuno-cytochemistry were consistent with that. And qRT-PCR results showed that lncRNA XIST and p21 were expressed at a higher level and has-miR-17-5p was expressed at a lower level in TAD than in NA. The predicted binding motifs of three up-regulated lncRNAs (ENSG00000248508, ENSG00000226530, and EG00000259719) were correlated with up-regulated RUNX1 (R=0.982, P< 0.001; R=0.967, P< 0.01; R=0.960, P< 0.01, respectively). No 29669321 Xist LncRNA Mus musculus Alzheimer Disease hippocampus tissues,cell lines Interaction[miR-124] qRT-PCR//IF//Western Blot The expression level of lncRNA XIST was significantly upregulated in AD models, both in vivo and in vitro. Silencing of lncRNA XIST negatively regulated miR-124 and positively regulated BACE1 expression in N2a cells, which is attenuated by cotransfection of anti-miR-124 oligodeoxyribonucleotide (AMO-124). Silencing of lncRNA XIST reversed the effect of H2 O2 on miR-124, BACE1, and Aβ1-42 expression in N2a cells, which was reversed by cotransfection of AMO-124. Silencing of lncRNA XIST attenuated AD-related BACE1 alteration through miR-124. No 31743528 Xist LncRNA Mus musculus Aortic Aneurysm, Thoracic rat arterial smooth muscle cells Interaction(miR-29b-3p/Eln pathway) RNA Pull-Down//Tunel//Flow Cytometry//qRT-PCR//RIP//FISH//Luciferase Report Assay Eln inhibition was identified to protect rat arterial smooth muscle cells from apoptosis. Also, miR-29b-3p was identified to bind to Eln, and X inactive specific transcript (Xist) could boost Eln expression through absorbing miR-29b-3p. Meanwhile, Eln overexpression counteracted the suppression of silenced Xist on the apoptosis of rat arterial smooth muscle cells. More importantly, such ceRNA network was proved to aggravate the apoptosis of human aortic smooth muscle cells. No 33761588 XAF1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 WTAPP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 WT1-AS LncRNA Homo sapiens Glioma glioma tissues and cell lines interaction[miR-494-3p] Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay In this study, we found that, levels of WT1-AS were significantly reduced in glioma tissues and cell lines. Targeting of WT1-AS, miR-494-3p, and AKT may be novel therapeutic options in treatment of glioma. No 32419643 WT1-AS LncRNA Homo sapiens Adenocarcinoma of Lung TCGA Interaction(miR-206/NAMPT Axis ) Survival Analysis In summary, the current study constructing a ceRNA-based WT1-AS/miR-206/NAMPT axis might be a novel important prognostic factor associated with the diagnosis and prognosis of LUAD. No 33540574 WT1-AS LncRNA Homo sapiens Adenocarcinoma of Lung LUAD samples Interaction( WT1-AS/IGF2BP2 axis) Western Blot WT1-AS and IGF2BP2 expression were positively correlated and increased in LUAD samples, while miR-200a-3p had relatively low expression. In summary, the WT1-AS/IGF2BP2 axis is a potential prognostic biomarker in LUAD and is expected to become an effective target for diagnosis and treatment. The high expression of WT1-AS and IGF2BP2 was associated with poor prognosis in LUAD patients, while low expression of miR-200a-3p predicted reduced survival (p < 0.05). No 35011587 WT1-AS LncRNA Homo sapiens Myelodysplastic Syndromes bone marrow Expression[highly expressed] qRT-PCR//Microarray Of the functionally described lncRNAs, we detected the upregulation of H19, EMCN-IT1, WT1-AS, MEG8, and PVT1 and the downregulation of ST6GAL2-IT1 and U5. No 32977510 WSB2-208 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 WNT8A LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 WNK1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 WIPI1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 WI2-87327B8.2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 WFDC21P LncRNA Homo sapiens Multiple Sclerosis blood Expression[highly expressed] qRT-PCR MALAT1 and lnc-DC were significantly increased in MS patients (P=0.004 and P=0.006, respectively) in comparison with controls. No 30514825 WFDC21P LncRNA Homo sapiens Multiple Sclerosis HLA-DRB1*15:01-Negative Patients Expression(highly expressed) qRT-PCR Our results have shown that lnc-DC expression level was significantly higher in total MS female patients compared with female controls (P = 0.0044). No 32951137 WFDC21P LncRNA Homo sapiens Behcet Syndrome BD patients Expression(lower expressed) qRT-PCR Compared to controls, the significant upregulation of NEAT1 {median [interquartile range (IQR)] = 1.68 (0.38-7.7), p < 0.0001} and downregulation of lnc-DC [median (IQR) = 0.2 (0.12-1.39), p = 0.03] were detected in the sera collected from BD patients. Also, high NEAT1 levels were significantly associated with a negative pathergy test, while higher lnc-DC was significantly associated with a positive family history Higher serum expression levels of NEAT1 and lnc-DC were significantly associated with the following clinical presentations: cutaneous lesions, vascular manifestations, articular manifestations, neurological manifestations, and higher disease activity score. No 35127819 WEE2-AS1 LncRNA Homo sapiens Glioblastoma GBM tissues and cells Interaction(IGF2BP3/PI3K-Akt signaling pathway) In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Co-IP//qRT-PCR//RIP//Luciferase Report Assay WEE2-AS1 was identified as a novel m6A-modified lncRNA that promotes GBM progression and was post-transcriptionally stabilized by IGF2BP3, an m6A reader. Moreover, we confirmed that WEE2-AS1 promoted RPN2 protein stabilization by preventing CUL2-mediated RPN2 K322 ubiquitination, thereby contributing to GBM malignant progression by activating the PI3K-Akt signaling pathway. No 36168628 WDR97 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 572 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 WDFY3-AS2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 WDFY3-AS2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 501 HNSCC tumor samples Regulation Bioinformatics Analysis The Prognostic Signature is based on 10 cuproptosis-related lncRNAs including AC090587.1, AC004943.2, TTN-AS1, AL162458.1, AC106820.5, AC012313.5, AL132800.1, WDFY3-AS2, CDKN2A-DT, and AL136419.3. The results of overall survival, risk score distribution, and survival status in the low-risk group were better than those in the high-risk group. In addition, all immune checkpoint genes involved were significantly different between the two risk groups (p < 0.05). The risk score was positively correlated with Eosinophils. M0 and M2 phenotype macrophages, mast cells activated, NK cells activated, and negatively related with B cells naive, mast cells resting, plasma cells, CD8T cells, T cells follicular helper, T cells regulatory (Tregs). No 35942287 WDFY3-207 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[lower expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 UGP2 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 UFC1 LncRNA Homo sapiens Pancreatic Neoplasms blood Expression[highly expressed] qRT-PCR The results indicated that serum UFC1 expression was relatively higher in PC patients than that in healthy volunteers. ROC curve analysis revealed that the serum UFC1 levels could distinguish PC patients from healthy controls, with an AUC value of 0.810. In addition, the serum UFC1 expression level was associated with lymph nodes metastasis, distant metastasis, and clinical stage. Kaplan-Meier analysis indicated that patients with high UFC1 expression exhibited shorter progression-free survival (PFS) and overall survival (OS) than those with low UFC1 expression. Multivariate analysis demonstrated that clinical stage and UFC1 expression level were significant, independent prognostic factors in PC patients. No 31933809 XIST LncRNA Homo sapiens Pancreatic Neoplasms PC tissues,cell lines Regulation[ miR-34a-YAP-EGFR axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Up-regulation of XIST and Yes associated protein (YAP) and down-regulation of miR-34a were consistently observed in the clinical specimens and PC cell lines.XIST promotes TGF-β1-induced EMT by regulating the miR-34a-YAP-EGFR axis in PC. No 31013436 UCA1 LncRNA Homo sapiens Sepsis One hundred seventy-four sepsis patients Expression(highly expressed) qRT-PCR//ELISA LncRNA UCA1 was highly expressed in sepsis patients compared with controls. lncRNA UCA1 upregulation was related to raised APACHE II score and SOFA score in sepsis patients. Moreover, lncRNA UCA1 was increased in sepsis deaths compared with sepsis survivors and was independently correlated with increased 28-day sepsis mortality risk. No 35441408 UCA1 LncRNA Homo sapiens Gastrointestinal Neoplasms Expression[highly expressed] Meta-analysis It is suggested that UCA1 abundance may serve as a reliable predictive factor for poor prognosis in patients with digestive system malignancies. A significant association was observed between UCA1 abundance and poor overall survival (OS), and shorter disease-free survival (DFS) for patients with digestive system malignancies, with pooled HR of 2.07 (95%CI: 1.74-2.47), and of 2.50 (95%CI: 1.62-3.86). No 31612385 UCA1 LncRNA Homo sapiens endometriosis of ovary eutopic endometrium tissues Expression[highly expressed] qRT-PCR The expression level of lncRNA UCA1 was significantly higher in ectopic endometrium tissues than in paired eutopic endometrium tissues for most of the patients. No 30994830 UCA1 LncRNA Homo sapiens Tongue Neoplasms tongue cancer tissues and cell lines Regulation[JAG1/Notch signaling] qRT-PCR In the present study, UCA1 was overexpressed in tongue cancer tissues and cell lines.UCA1 knockdown significantly suppressed TGFβ1-induced tongue cancer cell invasion and EMT by decreasing vimentin and increasing E-cadherin. Regarding the molecular mechanism, UCA1 could directly bind to microRNA-124 (miR-124) and negatively regulate each other. UCA1 knockdown ameliorated, whereas miR-124 inhibition exacerbated TGFβ1-induced EMT and invasion in tongue cancer cells through miR-124 downstream jagged 1 (JAG1) and Notch signaling. Moreover, miR-124 inhibition partially impaired the effect of UCA1 knockdown. In tongue cancer tissues, miR-124 expression was remarkably decreased, whereas JAG1 mRNA expression was increased. miR-124 was negatively correlated with UCA1 and JAG1. UCA1 and JAG1 were positively correlated. In summary, we provided a novel mechanism by which the EMT process and cancer cell invasion in tongue cancer could be modulated from the perspective of lncRNA-miRNA-mRNA regulation. UCA1 overexpression was correlated to the poorer prognosis of patients with tongue cancer. No 30635938 UCA1 LncRNA Homo sapiens Lymphatic Metastasis Expression[highly expressed] Meta-analysis A total of 3411 patients from 38 studies were finally included. Patients who with high UCA1 expression suffered from an increased risk of LNM (OR = 2.50; 95% CI: 1.93-3.25). UCA1 was also significantly associated with OS (HR = 2.05; 95% CI: 1.77-2.38). Subgroup analyses across several different variables also showed the similar results in LNM and OS of cancer patients. No 30918102 UCA1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells interaction[ Targeting MicroRNA-193a-3p] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay LncRNA UCA1 was increased in HCC, while microRNA-193a-3p was decreased. LncRNA UCA1 promotes malignant hyperproliferation of HCC cells by repressing microRNA-193a-3p. No 33154669 UCA1 LncRNA Homo sapiens Sars-Cov-2 Vaccination Breakthrough Infections 57 VBT and unvaccinated COVID-19 patients Expression(lower expressed) RNA-seq//Bioinformatics Analysis Further, out of the 12 lncRNA genes, 7 lncRNAs are reported to modulate immune/inflammatory responses in infectious diseases. Out of the 7 lncRNAs, LUCAT1, MALAT1, NEAT1 and GAS5 were downregulated in the VBT. LUCAT1 is a negative regulator of interferon response, and downregulation of LUCAT1 suggests an activated interferon response (30). MALAT1 is known to negatively regulate the immune response and positively regulate the inflammatory response in the infected individuals, therefore downregulation of MALAT1 in the breakthrough infection suggests an upregulated immune response and downregulated inflammatory response (31, 32). NEAT1 and GAS5 also act as pro-inflammatory lncRNAs, and their downregulation is an indicator of decreased inflammatory response in the VBT (33, 34). Amongst the upregulated lncRNAs, ROR1-AS1, UGDH-AS1 and LINC00273 were upregulated in the VBT. The upregulation of ROR1-AS1 and LINC00273 indicates a heightened immune response, whereas upregulation of UGDH-AS1 suggests a decreased disease severity possibly modulated by MOV10 and EDN1 (8). No 36466827 uc021ssa.1 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[lower expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 uc010yty.1 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[lower expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 uc010vaf.1 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[highly expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 uc010qna.2 LncRNA Homo sapiens Henoch-Schönlein Purpura Nephritis blood Expression[lower expressed] qRT-PCR//RNA-seq The results revealed that the expression of lncRNAs including ENST00000378432, ENST00000571370, uc001kfc.1 and uc010qna.2 was decreased in HSPN patients compared with that in healthy controls. No 30651843 UC004bhb.3 LncRNA Homo sapiens Cardiovascular Diseases blood Expression[highly expressed] qRT-PCR//Microarray To validate the microarray data, four up-regulated lncRNAs (NR_037652.1, ENST00000607654.1, ENST00000589524.1 and uc004bhb.3) were selected based on the functional co-expression networks, the signal value and the validation of designed primers. A description of the four strictly screened lncRNAs is presented in Table 5. The four lncRNAs were all up-regulated between 50 Uyghur SAP patients and 50 matched controls, which were consistent with the microarray data (Figure 8). The characteristics of the 100 validated participants are shown in Table 6. For an in-depth understanding of the four lncRNAs, the target genes are mainly based on correlation of at least 0.8, not only the possible function (Supplementary Figure S1). No 31413167 uc004ags.1 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[lower expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 uc003uey.1 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[lower expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 uc003qmb.5 LncRNA Homo sapiens brain glioma brain glioma tissues Expression[lower expressed] qRT-PCR Consistent with the microarray data, qPCR confirmed differential expression of these 6 lncRNAs (ak125809, ak098473, uc002ehu.1, bc043564, NR_027322, and uc003qmb.2) between tumor and peritumoral tissue. No 32051722 uc002ehu.6 LncRNA Homo sapiens brain glioma brain glioma tissues Expression[highly expressed] qRT-PCR Consistent with the microarray data, qPCR confirmed differential expression of these 6 lncRNAs (ak125809, ak098473, uc002ehu.1, bc043564, NR_027322, and uc003qmb.2) between tumor and peritumoral tissue. No 32051722 uc001kfc.1 LncRNA Homo sapiens Henoch-Schönlein Purpura Nephritis blood Expression[lower expressed] qRT-PCR//RNA-seq The results revealed that the expression of lncRNAs including ENST00000378432, ENST00000571370, uc001kfc.1 and uc010qna.2 was decreased in HSPN patients compared with that in healthy controls. No 30651843 uc001ejh.1 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[lower expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 uc001eiy.2 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[lower expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 uc.63 LncRNA Homo sapiens Breast Neoplasms breast cancer tissue samples Expression(it was shown that the expression of uc.63 and uc.38 is statistically significant, and, accordingly, higher (p < 0.0001) and lower (p < 0.0001) in the test group than in the control group. ) qRT-PCR As a result of the statistical analysis, it was shown that the expression of uc.63 and uc.38 is statistically significant, and, accordingly, higher (p < 0.0001) and lower (p < 0.0001) in the test group than in the control group. Statistical dependency analysis of the expression of uc.63 and uc.38 and the selected clinical and pathological factors showed that the expression of uc.63 statistically drops with the patient’s age (p = 0.04), and is higher in the breast cancer tissue type M1 according to the TNM classification (p = 0.036) and in tissues with overexpressed HER2 (p = 0.035). Conclusion. The obtained results of the statistical analysis indicate a relationship between the expression of uc.63 and uc.38 and the occurrence of breast cancer. Statistical dependency analysis of the expression of uc.63 and uc.38 and the selected clinical and pathological factors showed that the expression of uc.63 statistically drops with the patient’s age (p = 0.04), and is higher in the breast cancer tissue type M1 according to the TNM classification (p = 0.036) and in tissues with overexpressed HER2 (p = 0.035). No 35456414 uc.472+ LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] Microarray Moreover, the intersection analysis between 130 gene symbols and 73 gene symbols showed a total of nine miRNAs, and the number of targeted lncRNA was 11, which served as the differentially expressed lncRNA (Table 1). No 35117179 uc.38 LncRNA Homo sapiens Breast Neoplasms breast cancer tissue samples Expression(it was shown that the expression of uc.63 and uc.38 is statistically significant, and, accordingly, higher (p < 0.0001) and lower (p < 0.0001) in the test group than in the control group. ) qRT-PCR As a result of the statistical analysis, it was shown that the expression of uc.63 and uc.38 is statistically significant, and, accordingly, higher (p < 0.0001) and lower (p < 0.0001) in the test group than in the control group. Statistical dependency analysis of the expression of uc.63 and uc.38 and the selected clinical and pathological factors showed that the expression of uc.63 statistically drops with the patient’s age (p = 0.04), and is higher in the breast cancer tissue type M1 according to the TNM classification (p = 0.036) and in tissues with overexpressed HER2 (p = 0.035). Conclusion. The obtained results of the statistical analysis indicate a relationship between the expression of uc.63 and uc.38 and the occurrence of breast cancer. Statistical dependency analysis of the expression of uc.63 and uc.38 and the selected clinical and pathological factors showed that the expression of uc.63 statistically drops with the patient’s age (p = 0.04), and is higher in the breast cancer tissue type M1 according to the TNM classification (p = 0.036) and in tissues with overexpressed HER2 (p = 0.035). No 35456414 uc.336- LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).25). No 33330027 UC.145 LncRNA Homo sapiens Stomach Neoplasms gastric cancer cell lines Interaction( DKK1/ PRKG1-AS1/Wnt signaling) Western Blot//Migration Assay//qRT-PCR//RIP//Colony Formation Assay//Invasion Assay//ChIP Microarray analysis revealed that UC.145 exhibited the highest binding affinity to EZH2, a histone methyltransferase. The results indicated that UC.145 triggers DKK1 methylation via interaction with EZH2 and is involved in the canonical Wnt signaling pathway. Additionally, interaction between UC.145 and another long non-coding RNA adjacent to DKK1, PRKG1-AS1, induced a synergistic effect on Wnt signaling. No 35625973 uc.112 LncRNA Homo sapiens Leukemia, Biphenotypic, Acute bone marrow samples from children with T-ALL Expression(highly expressed) qRT-PCR//Bioinformatics Analysis The T-UCRs uc.112, uc.122, uc.160 and uc.262 were evaluated by quantitative real-time PCR in bone marrow samples from children with T-ALL (n=32) and common-ALL/pre-B ALL (n=30). In pediatric ALL, higher expression levels of uc.112 were found in patients with T-ALL, compared to patients with B-ALL. T-cells did not differ significantly from B-cells regarding uc.112 expression in non-tumor precursors from public data. No 32014474 UBXN1-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 UBE2G2-211 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 UBE2CP3 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR The levels of serum HULC, MALAT1, Linc00152, PTTG3P, SPRY4-IT1, UBE2CP3, and UCA1 were significantly higher in HCC patients than in patients with benign liver diseases and healthy controls, whereas serum PTENP1 was significantly decreased in HCC patients compared with healthy participants. No 32733618 UBE2C LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 UBA52P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 816 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 UCA1 LncRNA Homo sapiens Liver Neoplasms HCC tissues Expression[lower expressed] qRT-PCR UCA1 was upregulated and miR-18a was downregulated in HCC tissues. HCC patients with stage III-IV, tumor size ≥5 cm or multiple tumors expressed high level of UCA1. No 32329833 UCA1 LncRNA Homo sapiens Ischemic Stroke blood CD4+ T cells from 160 first-episode AIS patients and 160 non-AIS patients with high-stroke-risk factors Expression [highly expressed] qRT-PCR//ELISA LncRNA UCA1 expression was higher in AIS patients compared to controls (p < 0.001), and it was positively correlated to national institute of health stroke scale score (r = 0.436, p < 0.001), Th17 cell ratio (r = 0.398, p < 0.001), IL-6 (r = 0.204, p = 0.010), IL-17 (r = 0.326, p < 0.001), and ICAM1 (r = 0.276, p < 0.001) in AIS patients. No 33458871 UCK2 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 UCA1 LncRNA Homo sapiens Kidney Neoplasms renal cancer cell lines regulation[miR-182-5p/DLL4 axis] qRT-PCR//Luciferase Report Assay//Western Blot In this study, we found that UCA1 was significantly up-regulated in renal cancer. UCA1-miR-182-5p-DLL4 axis is involved in proliferation and progression of renal cancer. Moreover, increased UCA1 expression was positively correlated with differentiation and advanced TNM stage. No 31996265 UCA1a LncRNA Homo sapiens Uterine Cervical Neoplasms HeLa cells Interaction(PKM2) RNA Pull-Down//ChIP//Western Blot//qRT-PCR//RIP//RNA-seq//Cell Proliferation Assay//IF RNA sequencing results showed that overexpression of UCA1a resulted in extensive changes in the gene expression profile of HeLa cells, especially in the signaling pathway that regulates tumorgenesis. Mass spectrometry assay was conducted to show that pyruvate kinase M2 (PKM2) was a UCA1a-interacting protein. The 400 ~ 800 nt long region of UCA1a at the 5' end and the A1B domain of PKM2 were critical for the UCA1a-PKM2 interaction. Functional assays were performed to show that PKM2 was sufficient and necessary for UCA1a-induced proliferation of HeLa cells, which was partly due to the regulating of nuclear translocation and stabilization of PKM2. No 35927414 UCA1-203 LncRNA Homo sapiens Urinary Bladder Neoplasms urinary exosomes Expression[highly expressed] qRT-PCR LINC00355, UCA1-203, and MALAT1 expression was significantly higher in TCC patients compared to controls (non-malignant or normal samples). However, UCA1-201 expression was significantly decreased in TCC patients compared with controls. No 30568497 UCA1-201 LncRNA Homo sapiens Urinary Bladder Neoplasms urinary exosomes Expression[lower expressed] qRT-PCR LINC00355, UCA1-203, and MALAT1 expression was significantly higher in TCC patients compared to controls (non-malignant or normal samples). However, UCA1-201 expression was significantly decreased in TCC patients compared with controls. No 30568497 UCA1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[miR-495-3p] qRT-PCR//Colony Formation Assay//Transwell Assay Results showed higher expression of SATB1 and lncRNA-UCA1 but lower miR-495-3p expression in GC than in the normal tissues. In luciferase reporter assay, miR-495-3p bound to three seed sequences in SATB1 3'-UTR but only one in lncRNA-UCA1. SATB1 knockdown increased the combination of miR-495-3p with lncRNA-UCA1 but decreased lncRNA-UCA1 expression. Decreased lncRNA-UCA1 was also observed with the mimics increased miR-495-3p. These data suggested that SATB1 3'-UTR functions as a competing endogenous RNA of miR-495-3p and positively regulates lncRNA-UCA1. LncRNA-UCA1 knockdown only decreased SATB1 expression in MKN-45 cells but not in BGC-823 cells, which suggested that the regulatory effect of lncRNA-UCA1 on SATB1 by sponging miR-495-3p is cell-dependent. This study further identified that SATB1/miR-495-3p/lncRNA-UCA1 network is implicated in GC proliferation and invasion. The current study firstly revealed that SATB1 interacts with miR-495-3p/lncRNA-UCA1 network, whereby enhancing GC proliferation and invasion. No 30368875 UCA1 LncRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR The expression of UCA1 in serum of patients with gastric cancer was significantly higher than that of the normal control group. The expression level was not correlated with age, gender, clinical stage, lymph node metastasis, and distant metastasis, but negatively correlated with the differentiation of cancer cells. No 31532112 UCA1 LncRNA Homo sapiens Stomach Neoplasms tissues Regulation qRT-PCR//RNA-seq The results of our study demonstrated that the five-lncRNAs PART1, UCA1, DIRC3, HOTAIR, and HOXA11AS require more investigation to be confirmed as diagnostic biomarkers in gastric cancer. No 35949302 UCA1 LncRNA Homo sapiens Breast Neoplasms BC tissues Interaction[inhibiting miR-206] qRT-PCR//MTT//Luciferase Report Assay//Western Blot n this study, we first evaluated the correlation between UCA1 level and PTP1B expression in breast tissues, which showed the expression of PTP1B were much higher in the breast tumor tissues than in the peritumor normal tissues. We observed that UCA1 could Expression[up-expression]-regulate PTP1B expression in breast cancer cells. We also found that miR-206 could inhibit the expression of PTP1B by directly binding to the 3'-UTR of its mRNA. No 31695578 UCA1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] qRT-PCR In the present study, it was demonstrated that UCA1 was significantly upregulated in breast cancer tissues compared with healthy tissues. No 30628639 UCA1 LncRNA Homo sapiens Breast Neoplasms serum Expression(highly expressed) qRT-PCR Increased ANRIL (3.83-fold), TUG1 (7.64-fold), UCA1 (7.82-fold), and HIT (3.31-fold) expressions were observed in breast cancer patients compared to healthy controls. While lncRNA TUG-1 expression was found to be higher in patients with early-stage tumors than those with advanced-stage tumors (p = 0.06), lncRNA ANRIL showed increased expression in patients with PR positive status (p = 0.04). However, we found a significant difference in lncRNA HIT expression in HER-2 positive breast cancer patients compared to HER-2 negative breast cancer patients (p = 0.005). An increase in the expression of serum lncRNAs ANRIL (p < 0.0001), UCA-1 (p = 0.004), and HIT (p < 0.0001) was observed in the distant organ metastatic breast cancer patients. No 35132340 UCA1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Expression[highly expressed] qRT-PCR The expression levels of UCA1 and MALAT1 lncRNAs in ESCC tissues were significantly higher than those in adjacent carcinoma tissues, and there were statistically significant differences in TNM staging between the patients with high lncRNA expression and low lncRNA expression. The expression levels of UCA1 and MALAT1 lncRNAs in ESCC tissues were significantly higher than those in adjacent carcinoma tissues, and there were statistically significant differences in TNM staging between the patients with high lncRNA expression and low lncRNA expression. No 30002691 UCA1 LncRNA Homo sapiens Colorectal Neoplasms serum exosomes Expression[lower expressed] qRT-PCR In serum exosomes, UCA1 was downregulated, while circHIPK3 and TUG1 were upregulated. No 30195762 UCA1 LncRNA Homo sapiens Colorectal Neoplasms cell lines Interaction[transcription factor-A ] RNA Pull-Down//Western Blot//Co-IP//qRT-PCR//Transwell Assay In the present study, a novel molecular mechanism of UCA1, regulating the migratory and invasive capabilities of SW480 CRC cells was identified. UCA1 promoted the migration and invasion of SW480 cells by suppressing phosphorylation of myocardin-related transcription factor-A (MRTF-A). Our findings indicated that UCA1 competes with extracellular signal-regulated kinases1/2 to inhibit the phosphorylation of MRTF-A. These novel discoveries may reveal additional functions of UCA1, which may support future clinical development of novel drug targets. No 31579420 UCA1 LncRNA Homo sapiens Colorectal Neoplasms Expression[highly expressed] Meta-analysis The results showed that UCA1 overexpression was significantly correlated with poor overall survival in patients with CRC (HR = 2.25, 95% CI: 1.77-2.87, P < .001). No 31770217 UCA1 LncRNA Homo sapiens Colorectal Neoplasms normal colon cell lines FHC and CCD-18Co, Six human colon carcinoma cell lines, namely, LoVo, HT-29, CaCo-2, T-84, SW480, and DLD-1, Specimens from colon cancer patients Expression [highly expressed] qRT-PCR//Western Blot According to our results, UCA1 was significantly upregulated in colon cancer cell lines/tissues. No 33818320 UCA1 LncRNA Homo sapiens Colorectal Neoplasms CRC patient plasma Expression(highly expressed) qRT-PCR lncRNA urothelial carcinoma-associated 1 (UCA1) and lncRNA phosphoglucomutase 5-antisense RNA 1 (PGM5-AS1) were the most significantly up- and down-regulated lncRNAs in CRC patient plasma, respectively. The area under the ROC curve was calculated to be 0.766, 0.754 and 0.798 for UCA1, PGM5-AS1 and the combination of these two lncRNAs, respectively. Moreover, the diagnostic potential of these two lncRNAs was even higher for the early stages of CRC. The combination of UCA1 and PGM5-AS1 enhanced the AUC to 0.832, and when the lncRNAs were used with carcinoembryonic antigen (CEA), the AUC was further improved to 0.874. No 34212174 UCA1 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Expression[highly expressed] qRT-PCR qRT-PCR analysis revealed high UCA1 expression in PTC tissues and correlations between UCA1 expression levels and cervical lymph node metastasis and tumor staging in PTC, that is, higher UCA1 expression resulted in poorer PTC prognosis. qRT-PCR analysis revealed high UCA1 expression in PTC tissues and correlations between UCA1 expression levels and cervical lymph node metastasis and tumor staging in PTC, that is, higher UCA1 expression resulted in poorer PTC prognosis. No 30863094 UCA1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR The expression level of lncRNA NEAT1, H19, MALAT1, HOTAIR, DANCR, UCA1, and BCAR4 were significantly decreased, compared with that in adjacent noncancerous tissues (all P <.05). The expression level of lncRNA GAS5 was statistically significantly increased (P <.05). For the quantitative polymerase chain reaction (qPCR) assay, 8 kinds of lncRNAs were detected as a result of the GeXP assay. No 30423146 UCA1 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR The levels of serum HULC, MALAT1, Linc00152, PTTG3P, SPRY4-IT1, UBE2CP3, and UCA1 were significantly higher in HCC patients than in patients with benign liver diseases and healthy controls, whereas serum PTENP1 was significantly decreased in HCC patients compared with healthy participants. No 32733618 UCA1 LncRNA Homo sapiens Urinary Bladder Neoplasms blood Expression[highly expressed] qRT-PCR When comparing patients with BC to healthy controls, the expression of lncRNA UCA1, circFARSA, and circSHKBP1 was significantly increased. No 31934131 UCA1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[highly expressed] qRT-PCR UCA1 was significantly overexpressed in bladder tumors compared with normal urothelium, which was confirmed only in the case of NMIBC. Interestingly, reduced expression of UCA1 was correlated with muscle-invasive disease as well as with tumors of higher stage and grade. UCA1 loss was strongly associated with higher risk of short-term relapse [hazard ratio (HR) = 1.974; P = 0.032] and progression to invasive stages (HR = 3.476; P = 0.023) in NMIBC. No 30815670 UCA1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] qRT-PCR Expression of UCA1 and TUG1 genes was up-regulated in 54.83 % and 53.12 % OSCC tumors, respectively. No 33410422 UCA1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 209 OSCC patients Mutation(rs7255437) Genotyping Using multivariate Cox hazards regression analysis, a predictive role of NEAT1 rs3741384 GG and UCA1 rs7255437 TC+TT in a worse prognosis of OSCC was identified. No 33384238 UCA1 LncRNA Homo sapiens Leukemia, Myeloid, Acute plasma exosomal Expression(lower expressed) qRT-PCR Subsequently, the downregulated plasma exosomal lncRNAs (LINC00265, LINC00467, and UCA1) and the upregulated plasma exosomal lncRNA (SNHG1) were identified in AML patients (n=65) compared to HD (n=20). No 36276083 UCA1 LncRNA Homo sapiens Esophageal Neoplasms cancerous tissues and marginal tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//Western Blot "lncRNA-UCA1 gene expression changes were assessed by Real-time PCR in 70 paired tissues of EC. The results of our research exhibited the lncRNA-UCA1 was Expression[Expression[up-expression]-expression]-regulated in cancerous tissues versus the marginal tissues (P < 0.001)" No 31414398 UCA1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Regulation[UCA1/miR-493-5p/HK2 axis ] CCK8//qRT-PCR//Western Blot In order to explore the role of UCA1 in cervical cancer, first, the expression levels of UCA1 in cervical cancer tissues were measured, and the results showed that UCA1 levels were higher in cancer tissues compared to matched adjacent normal tissues. In a summary, this study demonstrated that UCA1 functioned as an oncogene by UCA1/miR-493-5p/HK2 axis in cervical cancer. No 31949782 UCA1 LncRNA Homo sapiens Glioma glioma tissues Expression[highly expressed] qRT-PCR Here, we report that the expression of UCA1 is significantly increased by transforming growth factor-β (TGF-β) treatment in glioma cells and is greater in glioma tissues than in normal adjacent tissues. No 30410864 UCA1 LncRNA Homo sapiens Glioma glioma cell lines and tissues Regulation[miR-206/CLOCK axis ] qRT-PCR//IF//Western Blot//Transwell Assay LncRNA UCA1 was up-regulated in glioma cell lines and tissues. Overall, the results demonstrated that UCA1/miR-206/CLOCK axis participated in the progressing of glioma and could act as a promising therapeutic target. No 31798345 UCA1 LncRNA Homo sapiens Glioma glioma samples Interaction( UCA1/miR-182/PFKFB2 axis) Transfection//Immunoblotting//qRT-PCR//Luciferase Report Assay//ELISA//IHC//Transwell Assay In this study, lncRNA UCA1/miR-182 axis has been regarded as a nodal driver of glioma invasion mediated by GB-associated stromal cells (GASCs) and GASC-secreted chemokine CXCL14.Notably, CXCL14-high GASCs mediated lncRNA UCA1 upregulation and miR-182 downregulation in glioma cells. Moreover, miR-182 directly bound to the fructose-2,6-biphosphatase PFKFB2; UCA1/miR-182 axis thereby modulated GASC-induced glycolysis in glioma cells. Overall, UCA1/miR-182/PFKFB2 axis modulates chemokine CXCL14 secretion, glycolysis and invasion of glioma cells in GASCs. In clinical specimens, CXCL14 upregulation in GASCs also correlated with poor prognosis. No 29655792 UCA1 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues and cell lines Expression[highly expressed] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay The high levels of UCA1 and EIF4G1 as well as the low level of miR-331-3p were observed in PCa tissues and cell lines. No 32943997 XIST LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 XIST LncRNA Homo sapiens Triple Negative Breast Neoplasms serum Expression(highly expressed) qRT-PCR Levels of serum exo-XIST were only significantly increased in TNBC recurrence and no association with other clinicopathological parameters. Levels of serum exo-XIST were only significantly increased in TNBC recurrence and no association with other clinicopathological parameters. Finally, an obvious association was identified between serum exo-XIST levels and a poorer overall survival (OS) in TNBC patients. No 33949761 TYMSOS LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction(TYMSOS/hsa-miR-101-3p/CEP55 and TYMSOS/hsa-miR-195-5p/CHEK1 Axis) Bioinformatics Analysis We concluded that TYMSOS/hsa-miR-101-3p/CEP55 and TYMSOS/hsa-miR-195-5p/CHEK1 ceRNA regulatory aixs may play vital roles in the occurrence and development of NSCLC, and may provide novel therapeutic targets in the future. No 36352081 ZNF19-211 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ZHX1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ZFPM2-AS1-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ZFPM2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR It was identified that the expression levels of lncRNA ZFPM2-AS1 were significantly increased in HCC tissues, whereas expression levels of the ZFPM2 gene were significantly decreased in HCC tissues compared with normal liver tissues. Higher expression levels of ZFPM2-AS1 were significantly associated with a less favorable prognosis of HCC, whereas higher expression levels of the ZFPM2 gene were associated with a more favorable prognosis of HCC. Genetic alterations in the ZFPM2 gene may contribute to a worse prognosis of HCC. No 32382322 ZFHX3-206 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ZFAS1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)32) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 ZFAS1 LncRNA Homo sapiens Stomach Neoplasms 102 pairs of tumorous and adjacent non-tumorous gastric biopsy samples of GC cases Expression [lower expressed] qRT-PCR The PVT1 and ZFAS1 expressions showed a significant increase and decrease in GC samples as compared with non-cancerous tissues, respectively. PVT1 expression was significantly associated with and lymph-node involvement (p = 0.0007). Moreover, ZFAS1 expression demonstrated a significant association with lymph-node involvement (p = 0.0005), and tumor size >5 cm (p = 0.003). No 34546507 ZFAS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[Targeting MiR-7-5p] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay Our results showed that ZFAS1 was upregulated in CRC tissues, correlated with overall survival rates, and negatively related to the expression of miR-7-5p.It was verified that miR-7-5p was a direct target of ZFAS1 by bioinformatics analysis and luciferase reporter assay. In addition, knockdown of miR-7-5p inhibited proliferation, migration, and invasion, and promoted apoptosis in CRC cell lines, which could be rescue by miR-7-5p inhibitor. No 31295229 ZFAS1 LncRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR The combination of ZFAS1, SNHG11, LINC00909 and LINC00654 showed high diagnostic performance for CRC (AUC: 0.937), especially early-stage disease (AUC: 0.935). Plasma levels of the four candidate lncRNAs were significantly reduced in postoperative samples compared to preoperative samples. No 31633800 ZFAS1 LncRNA Homo sapiens Colorectal Neoplasms CRC cells and paired CRC cohorts Expression(highly expressed) qRT-PCR//IHC//IF We identified that the crosstalk of the m6A reader IMP2 with long-noncoding RNA (lncRNA) ZFAS1 in an m6A modulation-dependent manner, subsequently augmented the recruitment of Obg-like ATPase 1 (OLA1) and adenosine triphosphate (ATP) hydrolysis and glycolysis during CRC proliferation and progression. Specifically, IMP2 and ZFAS1 are significantly overexpressed with elevated m6A levels in CRC cells and paired CRC cohorts. No 34743750 ZFAS1 LncRNA Homo sapiens Carcinoma, Hepatocellular 214 plasma samples Expression [highly expressed] qRT-PCR The levels of plasma ZFAS1 in HCC were significantly higher than those in healthy controls (P<0.001), and in patients with cirrhosis and hepatitis B (P<0.001), and was positively associated with serum α-fetoprotein (AFP). The levels of plasma ZFAS1 in HCC were significantly higher than those in healthy controls (P<0.001), and in patients with cirrhosis and hepatitis B (P<0.001), and was positively associated with serum α-fetoprotein (AFP). Meanwhile, the area under the receiver operating characteristic curve (AUC) of ZFAS1 was 0.801 to diagnose HCC from healthy controls, while AFP was 0.798 and the combined AUC of ZFAS1 and AFP was 0.891 (95% CI: 0.829-0.953), slightly higher than ZFAS1 alone. No 29559565 ZFAS1 LncRNA Homo sapiens Osteosarcoma cell lines Interaction[miR-646] Western Blot//Migration Assay//qRT-PCR//Colony Formation Assay//Invasion Assay//Transwell Assay Our study showed that ZFAS1 was up-regulated in OS cells and promoted the colony formation, migration, and invasion of OS cells via activating the MAPK signaling pathway. Furthermore, the experimental results indicated that miR-646 was a target of ZFAS1 and there was a negative relationship between ZFAS1 and miR-646 expression. Additionally, we found that ZFAS1 in OS cells up-regulated the expression of NOB1 through sponging miR-646, finally facilitating the growth of the OS cells. No 31081072 ZFAS1 LncRNA Homo sapiens Nasopharyngeal carcinoma cell lines Expression[highly expressed] qRT-PCR After performing qRT-PCR analysis, we found that the expression of ZFAS1 and ENO2 was upregulated in NPC cells but that the miR-7-5p expression was downregulated in the same samples. No 33342344 ZFAS1 LncRNA Homo sapiens Sepsis blood Expression[lower expressed] qRT-PCR//ELISA Our study revealed that: LncRNA ZFAS1 expression was lower in sepsis patients compared to HCs, and it presented with a good value in predicting sepsis susceptibility; LncRNA ZFAS1 expression was negatively correlated with APACHE II score and inflammatory markers levels; LncRNA ZFAS1 expression was lower in nonsurvivor group compared to survivor group, and it had the potential to distinguish nonsurvivors from survivors in sepsis patients. No 30817573 ZFAS1 LncRNA Homo sapiens degenerative disc disease Lumbar disc tissue Expression[Expression[highly expressed]-expression] qRT-PCR//Western Blot HNP lncRNA ZFAS1 expression in LDD patients was Expression[Expression[up-expression]-expression]-regulated compared with controls (P < .001) HNP lncRNA ZFAS1 expression in LDD patients was Expression[Expression[up-expression]-expression]-regulated compared with controls (P < .001), and receiver operating characteristic (ROC) curve showed lncRNA ZFAS1 expression disclosed a good predictive value for LDD risk with area under curve (AUC) 0.753 (95% CI 0.646-0.859). And after adjustment by age, gender and body mass index (BMI), lncRNA ZFAS1 (P = .017) remained to be an independent predictive factor for higher LDD risk. No 31876730 ZFAS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck cell lines Expression[highly expressed] qRT-PCR The expression of ZFAS1 was up-regulated in the metastatic FaDu cell line relative to the less aggressive SCC-25 and SCC-040 and dysplastic DOK cell lines.The analysis of genes associated with ZFAS1, as well its targets, indicate that they are linked with crucial cellular processes. In the group of patients with low expression of ZFAS1, we detected the up-regulation of suppressors and down-regulation of genes associated with epithelial-to-mesenchymal transition (EMT) process, metastases, and cancer-initiating cells. Moreover, the negative correlation between ZFAS1 and its host gene, ZNFX1, was observed. The analysis of interactions indicated that ZFAS1 has a binding sequence for miR-150-5p. The expression of ZFAS1 and miR-150-5p is negatively correlated in HNSCC patients. miR-150-5p can regulate the 3'UTR of EIF4E mRNA. In the group of patients with high expression of ZFAS1 and low expression of miR-150-5p, we detected an up-regulation of EIF4E. The ZFAS1 levels typically differed depending on the cancer stage and T-stage. Patients with a lower expression of ZFAS1 presented a slightly longer disease-free survival and overall survival. No 31010087 ZFAS1 LncRNA Homo sapiens Heart Failure serum Interaction(ZFAS1/miR-590-3p axis) qRT-PCR the serum levels of ZFAS1 were significantly higher, while miR-590-3p levels were significantly lower in CHF. ROC results indicated that the combined diagnostic accuracy of ZFAS1 + miR-590-3p + BNP was significantly higher than that of these indicators used alone. Kaplan- Meier results showed that patients with low expression of miR-590-3p or high expression of ZFAS1 had poor prognosis. In conclusion, CHF patients had increased ZFAS1 and decreased miR-590-3p expression. ZFAS1 and miR-590-3p might serve as novel non-invasive diagnostic and prognostic markers for patients with CHF. ROC results indicated that the combined diagnostic accuracy of ZFAS1 + miR-590-3p + BNP was significantly higher than that of these indicators used alone. Kaplan- Meier results showed that patients with low expression of miR-590-3p or high expression of ZFAS1 had poor prognosis. No 34319554 Zfas1 LncRNA Mus musculus Myocardial Reperfusion myocardial tissues regulation[miR-590-3p/NF-κB signaling pathway] qRT-PCR//Western Blot It was demonstrated that ZFAS1 was upregulated and miR?590?3p was downregulated in the in vitro model of cardiac I/R injury. Collectively, the present results suggested that ZFAS1 was upregulated in H9c2 cells subjected to I/R injury, and that ZFAS1 knockdown protected against I/R‑induced myocardial cell apoptosis by directly interacting with miR‑590‑3p, via the NF‑κB pathway. No 32705215 ZEB2-AS1 LncRNA Homo sapiens Breast Neoplasms Breast Cancer tissues Expression[highly expressed] qRT-PCR Our data showed a significant upregulation of ARA and ZEB2NAT lncRNAs in tumor tissues compared to NATs (p <0.001; p = 0.021, respectively). ARA and ZEB2NAT expression were observed to be significantly associated with tumor grade, nuclear grade, tumor stages, and lymph node metastasis (p <0.05). Additionally, ARA expression was significantly correlated with breastfeeding status (p = 0.027). No 32921528 ZEB2-AS1 LncRNA Homo sapiens Triple Negative Breast Neoplasms breast cancer tissues, cells (MDA231) Interaction[ZEB2] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay In this study, we found that LncRNA-ZEB2-AS1 was dramatically up-regulated in our breast cancer specimens and cells (MDA231), especially in metastatic tumor specimens and highly invasive cells, and high lncRNA-ZEB2-AS1 expression is associated with clinicopathologic features and short survival of breast cancer patients.Thus, it is regarded as an oncogene in triple-negative breast cancer. It is mainly endo-nuclear and situated near ZEB2, positively regulating ZEB2 expression and activating the epithelial mesenchymal transition via the PI3K/Akt/GSK3β/Zeb2 signaling pathway. Meanwhile, EGF-induced F-actin polymerization in MDA231 cells can be suppressed by reducing lncRNA-ZEB2-AS1 expression. The migration and invasion of triple-negative breast cancer can be altered through cytoskeleton rearrangement. In summary, we demonstrated that lncRNA-ZEB2-AS1 is an important factor affecting the development of triple-negative breast cancer and thus a potential oncogene target. In this study, we found that LncRNA-ZEB2-AS1 was dramatically up-regulated in our breast cancer specimens and cells (MDA231), especially in metastatic tumor specimens and highly invasive cells, and high lncRNA-ZEB2-AS1 expression is associated with clinicopathologic features and short survival of breast cancer patients. No 30825262 ZEB2-AS1 LncRNA Homo sapiens Prostatic Neoplasms tumoural tissues Expression(highly expressed) qRT-PCR The expression levels of the BCL-2 gene and ZEB2-AS1 lncRNA were upregulated in tumoural tissues in comparison to adjacent non-cancerous tissues (ANCTs) and BPH tissues. In contrast, the expression level of BALR-2 lncRNA was significantly higher in BPH compared with tumoural tissues. No 34866225 ZEB2-AS1 LncRNA Homo sapiens Coronary Artery Disease 40 CAD patients and 40 healthy individuals Expression(highly expressed) qRT-PCR The expressions of IFNG-AS1 lncRNA as well as IFN-γ and ZEB2 genes were significantly reduced in CAD patients compared to healthy subjects. In contrast, the expression of ZEB2-AS1 was up-regulated in these patients. Linear regression analysis unveiled that there is a positive correlation between the expression of IFNG-AS1 and IFN-γ, also similarly, ZEB2-AS1 and ZEB2 in PBMCs of subjects. Moreover, the expression of IFNG-AS1 and ZEB2-AS1 correlated with the Gensini score. No 35389131 ZEB2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ZEB2 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Expression[highly expressed] qRT-PCR qPCR results indicated marked upregulation of CDKN2A-AS1, C7orf55, LINC00184, HEIH, and ZEB2 expression, whereas that of SNHG3, LINC00630, LOC100133669, APTR, LINC-PINT, and SEMA5A was downregulated in OC tissues as compared with levels in normal ovary tissues (Fig. ?(Fig.5b5b). No 31098301 ZEB1-AS1 LncRNA Homo sapiens Stomach Neoplasms Gastric Cancer tissues Expression[highly expressed] qRT-PCR The results showed that the expression levels of ZEB1 antisense RNA 1 in gastric cancer tissues were significantly higher than those in the paracancerous tissues ( P < .001). Moreover, the high ZEB1 antisense RNA 1 expression was associated with tumor, nodes, and metastases stage IV ( P = .018) and loss of E-cadherin expression ( P = .033). Multivariate Cox hazards regression analysis revealed that high ZEB1 antisense RNA 1 expression was an independent risk factor for predicting poor prognosis in patients with advanced gastric cancer (hazard ratio = 1.530, 95% confidence interval, 1.052-2.224, P = .026). No 31072267 ZEB1-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Expression(lower expressed) qRT-PCR//Bioinformatics Analysis According to the qRT-PCR assay, the expression levels of LINC01133 and ZEB1-AS1 were decreased in luminal BC tissues and cell lines. On the other hand, ABHD11-AS1 was upregulated in the above-mentioned samples. The expression levels of LINC01133, ZEB1-AS1, and ABHD11-AS1 were not associated with any of the clinical features. Also, the results obtained from the bioinformatics analyses were consistent with qRT-PCR data. No 34446052 ZEB1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR In the present study, we found that lncRNA ZEB1-AS1 was upregulated in NSCLC tissues compared to adjacent non-tumor tissues. In addition, upregulated lncRNA ZEB1-AS1 expression was significantly associated with lymph node metastasis and TNM stage (P<0.05). No 31949753 ZEB1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC patients Expression(lower expressed) Bioinformatics Analysis According to our findings, individuals with reduced ZEB1-AS1 expression had a better prognosis in CRC. According to our findings, individuals with reduced ZEB1-AS1 expression had a better prognosis in CRC. No 35794981 ZEB1-AS1 LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis Taken together, high expression level of lncRNA ZEB1-AS1 is detected in numerous cancer types, which is related to the poor OS, RFS, LNM, PHG as well as HTS. No 31027073 ZEB1-AS1 LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis The high expression of ZEB1-AS1 significantly predicted poor OS, poor metastasis, and high tumor stage in cancer patients, demonstrating that high ZEB1-AS1 expression may serve as a biomarker of poor prognosis in the Chinese cancer patients. No 32756112 ZNF101P2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 730 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ZNF204P LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 ZEB1-AS1 LncRNA Homo sapiens Colonic Neoplasms COAD tissues Regulation[miR-455-3p/PAK2 axis] RNA Pull-Down//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay We found that ZEB1-AS1 expression was significantly up-regulated in COAD tissues, and high ZEB1-AS1 level was correlated with the poor prognosis of COAD patients. We confirmed that ZEB1-AS1 promotes PAK2 expression by sponging miR-455-3p, thus facilitating COAD cell growth and metastasis. We found that ZEB1-AS1 expression was significantly up-regulated in COAD tissues, and high ZEB1-AS1 level was correlated with the poor prognosis of COAD patients. No 31828845 ZNF204P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ZSCAN12P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ZSCAN12P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 925 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ZRANB2-AS2-227 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ZRANB2 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ZNNT1 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 ZNF714 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ZNF707 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ZNF667-AS1-209 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ZNF667-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ZNF667-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Expression(lower expressed) qRT-PCR//Wound Healing Assay//Colony Formation Assay The expression levels of lncRNA ZNF667-AS1 were decreased in malignant tumor tissues. The OSCC patients with high expression of lncRNA ZNF667-AS1 had a longer survival time. IncRNA ZNF667-AS1 inhibited cell proliferation, cell clone formation ability, invasion and migration. Furthermore, lncRNA ZNF667-AS1 could inhibit the EMT process by suppressing transforming growth factor-β-1 (TGF-β1) expression, and TGF-β1 treatment could partially restore the inhibitory effect. No 34258957 ZNF667-AS1 LncRNA Homo sapiens Glioma glioma tissues Expression[highly expressed] CCK8//qRT-PCR We observed that ZNF667-AS1 was significantly upregulated in glioma tissues compared to normal tissue samples (p < 0.01). Higher levels of ZNF667-AS1 were positively associated with the WHO grade (p = 0.018) and KPS score (p = 0.008). ROC assays revealed that the high ZNF667-AS1 expression had an AUC value of 0.8541 (95% CI: 0.8148 to 0.8934) for glioma. Survival data revealed that glioma patients in the high ZNF667-AS1 expression group had significantly shorter 5-year overall survival (p = 0.0026) and disease-free survival (p = 0.0005) time than those in the low ZNF667-AS1 expression group. No 33282010 ZNF625 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ZNF609-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ZNF609 CircRNA Homo sapiens Adenocarcinoma of Lung LAUD tissues and cell lines regulation[miR-1224-3p/ETV1 Signaling] colony Formation Assay//qPCR//PCR//IP//Colony Formation Assay//IF Circ-ZNF609 was significantly upregulated in LAUD tissues and cell lines, and its inhibition induced reduced cell proliferation of LAUD cells. Circ-ZNF609 enhances LAUD progression by increasing oncogenic EVT1 expression via sponging miR-1224-3p, revealing that circ-ZNF609/miR-1224-3p/ETV1 axis may be a promising therapeutic target for LAUD treatment. No 32308483 ZNF582-DT LncRNA Homo sapiens Breast Neoplasms breast tumors than adjacent normal tissues Interaction(hsa-miR-940) Bioinformatics Analysis ZNF582-AS1 expression was lower in breast tumors than adjacent normal tissues. Low ZNF582-AS1 was associated with high-grade or ER-negative tumors. Patients with high ZNF582-AS1 had a lower risk of relapse and death. These survival associations were confirmed in a meta-analysis and remained significant after adjustment for tumor grade, disease stage, patient age, and hormone receptor status. Correlation analysis indicated the possible suppression of ZNF582-AS1 expression by promoter methylation. Bioinformatics interrogation of molecular signatures suggested that ZNF582-AS1 could suppress tumor cell proliferation via downregulating the HER2-mediated signaling pathway. Analysis of online data also suggested that HIF-1-related transcription factors could suppress ZNF582-AS1 expression, and the lncRNA might bind to hsa-miR-940, a known oncogenic miRNA in breast cancer. Patients with high ZNF582-AS1 had a lower risk of relapse and death. No 35681777 ZNF567-DT LncRNA Homo sapiens Osteoarthritis OA cartilage tissue,cell line Interaction[Targeting miR-140-5p] qRT-PCR The results showed that LINC01534 was upregulated in both OA cartilage tissue and OA chondrocyte model.Therefore, LINC01534 could promote the abnormal matrix degradation and inflammatory response of OA chondrocytes through the targeted binding of miR-140-5p. No 31735077 ZNF567-DT LncRNA Homo sapiens Endometrial Neoplasms Serum and tissue samples Expression(highly expressed) RNA-seq At the same time, lncRNA sequencing results showed that when endometrial atypical hyperplasia continued to change, including LINC00511, PVT1, and IQCH-AS1 (downregulated), and only changed significantly in the endometrial dysplasia group, including MALAT1, CARMN (downregulated) and LINC00648, BISPR, LINC01534, and LINC00930 (upregulated). No 36510632 ZNF518A-207 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ZNF518A CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ZNF503-AS2 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).15). No 33330027 ZNF407-AS1 LncRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR The combination of ZFAS1, SNHG11, LINC00909 and LINC00654 showed high diagnostic performance for CRC (AUC: 0.937), especially early-stage disease (AUC: 0.935). Plasma levels of the four candidate lncRNAs were significantly reduced in postoperative samples compared to preoperative samples. No 31633800 ZNF385D-AS2 LncRNA Homo sapiens Liver Neoplasms liver cancer tissues Expression[Expression[lower expressed]-expression] RNA-seq Based on the results, analysis of RNA‑Seq gene expression data for 303 patients with primary tumors revealed low expression of ZNF385D‑AS2 in liver cancer. We generated Kaplan-Meier curves of overall survival (OS), and log-rank tests showed that ZNF385D-AS2 low-expression was associated with poor OS (P=0.0079; Fig. 3A). Further subgroExpression[Expression[up-expression]-expression] analysis (Fig. 3A-O) showed that ZNF385D-AS2 low-expression was associated with the poor OS of patients with sex (male) (P=0.015; Fig. 3D), M0 stage (P=0.0099; Fig. 3H), N0 stage (P=0.028; Fig. 3I), age ≤55 (P=0.023; Fig. 3J), early pathological stage (G1/2) (P=0.044; Fig. 3L) and race (Asian) (P=0.0046; Fig. 3N). No 31322274 ZNF385D-206 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ZNF33BP1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 707 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ZNF300P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ZNF300P1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 ZNF295-AS1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ZNF267 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ZNF224-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 ZEB1-AS1 LncRNA Homo sapiens Melanoma cell lines Expression[highly expressed] RNA-seq Also, we observed upregulation of the lncRNA ZEB1-AS1 (ZEB1 antisense RNA 1) in melanoma cell lines. No 31383874 ZEB1-210 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 XIST LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis A total of 18 retrospective studies with 1351 cancer patients were included. Current meta-analysis revealed that elevated lncRNA XIST expression was associated with poor overall survival (OS) (HR = 2.14, 95% CI = 1.26-3.64; P = .005) and disease free survival (DFS) (HR = 4.52, 95% CI = 1.42-14.37; P = .011). A total of 18 retrospective studies with 1351 cancer patients were included. Current meta-analysis revealed that elevated lncRNA XIST expression was associated with poor overall survival (OS) (HR = 2.14, 95% CI = 1.26-3.64; P = .005) and disease free survival (DFS) (HR = 4.52, 95% CI = 1.42-14.37; P = .011). The clinicopathological parameters analysis demonstrated that increased XIST expression was significantly associated with tumor size (OR = 2.93, 95% CI = 2.24-3.84; P < .001), clinical stage (OR = 2.73, 95% CI = 1.62-4.58; P < .001) and lymph node metastasis (OR = 2.44, 95% CI = 1.74-3.42; P < .001). No 30653128 XLOC_013931 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 XLOC_012430 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)82) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 XLOC_011789 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 XLOC_010820_2 LncRNA Homo sapiens Sepsis blood Expression[lower expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 XLOC_009459 LncRNA Homo sapiens Colorectal Neoplasms Exosomal Expression(highly expressed) qRT-PCR Exosomal FOXD2-AS1, NRIR, and XLOC_009459 (TCONS_00020073) levels were significantly upregulated in 203 CRC patients and 80 early-stage CRC patients compared to 201 healthy donors, possessing the area under the curve (AUC) of 0.728, 0.660, and 0.682 for CRC, as well as 0.743, 0.660, and 0.689 for early-stage CRC, respectively. No 33777763 XLOC_009198 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)91) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 XLOC_008852 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)73) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 XLOC_007858 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)74) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 XLOC_006599 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)88) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 XLOC_006390 LncRNA Homo sapiens Pancreatic Neoplasms Interaction[XLOC_006390/c-Myc ] Transwell Assay//Western Blot//qRT-PCR//RIP//Colony Formation Assay//ChIP The dysregulated lncRNA/c-Myc axis increased glutamate metabolism, promoting PC progression to a higher stage. Therefore, XLOC_006390/c-Myc may be a potential target for PC, and its abnormal activation also indicates the progression of PC. No 31734356 XLOC_004923 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)59) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 XLOC_004244 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)52) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 XLOC_003808 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)87) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 XLOC_003422 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)107) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 XLOC_002067 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)99) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 XLOC_000889 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)7) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 XLOC_000333 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[lower expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 XKR6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 XIST LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues ,cell lines Regulation[miR-212-3p/CBLL1 axis] CCK8//qRT-PCR//RIP//Western Blot Expression levels of XIST and CBLL1 were markedly upregulated, while the miR-212-3p level was markedly downregulated in NSCLC tissues and cells. No 31646569 XIST LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR The expression of XIST was significantly higher in NSCLC samples compared to non-cancerous samples (P < .001). Statistically significant correlations were observed between high tissue XIST expression level and lymph node metastasis (P = .036) and high Tumor Node Metastasis (TNM) stage (P = .002). The log-rank test indicated that patients with increased XIST expression experienced poor overall survival (P = .006). No 33327221 XIST LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC cells Regulation Bioinformatics Analysis Therefore, our results support that lncRNA XIST is an attractive target of drug development in tumor growth and aggressive proliferation of NSCLC, and promising results can be achieved through tumor suppressor miRNAs. No 35453680 XIST LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 XIST LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and adjacent tissues,cell lines(LOVO，HT-29，HCT8，HCT116，SW480,DLD1,HCoEpics) Expression[highly expressed] qRT-PCR lncRNA XIST was upregulated in CRC cells lines and tissues (p<0.05). Moreover, higher expression of XIST could predict poor progression-free survival (PFS) and poor overall survival (OS) of CRC patients. The M stage and high expression of XIST were proven to be independent risk factors for poor prognosis (p<0.05). No 31452526 XIST LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR Our results demonstrated that XIST and ROR1 expressions were dramatically up-regulated, yet miR-30a-5p expression was down-regulated within colorectal cancer tissues (P < 0.05). No 30907503 XIST LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues,cell lines Regulation[XIST/miR-486 -5p/NRP-2 axis] Flow Cytometry//MTT//Colony Formation Assay//Transwell Assay Our study results demonstrated that CRC tissues and cells were detected with significantly elevated XIST and NRP-2 expressions as well as markedly reduced miR-486-5p expression when compared with normal tissues and cells (all p < 0.05). In conclusion, the XIST/miR-486 -5p/NRP-2 axis appeared to participate in the progression of CRC, which could assist in developing efficacious therapies for CRC. No 30656681 XIST LncRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR XIST in serum EVs in CRC patients was upregulated, with greatest diagnostic value. CRC patients with higher expression of XIST in serum EVs had worse 5-year survival rates and shorter life cycles, lower differentiation, higher lymph node metastasis, and tumor-node-metastasis than patients with lower XIST expression. No 32843612 XIST LncRNA Homo sapiens Colorectal Neoplasms cells and tissues regulation[miR-93-5p/HIF-1A/AXL signaling pathway] qRT-PCR//Luciferase Report Assay//RIP In the present research, our team demonstrated the upregulation of XIST expression, which was related to tumor progression, and the downregulation of miR-93-5p in cells and tissues of colorectal cancer.In summary, the above results indicate that XIST promotes colorectal cancer tumorigenesis by regulating miR-93-5p/HIF-1A/AXL signaling pathway, which will supply a novel perspective to diagnose and treat colorectal cancer disease. No 32061057 XIST LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[XIST/miR-497-5p/PDCD4 axis] qRT-PCR//Transwell Assay//Western Blot lncRNA XIST was observed to be downregulated in the HCC tissues and positively correlated with the expression of PDCD4.lncRNA XIST was found to act as a miR-497-5p sponge and to regulate the level of PDCD4, which is targeted by miR-497-5p. No 31384173 XIST LncRNA Homo sapiens Ovarian Neoplasms ovarian tissues Expression[lower expressed] qRT-PCR In this study, we found that lncRNA XIST was significantly overexpressed in normal ovarian tissues and down-regulated in OC. Moreover, we showed XIST was associated with the development of OC and down-regulated in advanced stage OC compared to early-stage OC samples. Overexpression of XIST was significantly associated with longer survival in patients with OC. No 32233524 XIST LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Saliva Regulation qRT-PCR Salivary XIST expression was only observed in females, and a high proportion of females with OSCC lack salivary lncRNA XIST expression (88%). People lacking salivary lncRNA XIST expression had a significantly increased odds ratio of suffering from OSCC (OR = 19.556, p < 0.001), particularly females (OR = 33.733, p < 0.001). No 34640640 XLOC_013290 LncRNA Homo sapiens COVID-19 39 COVID-19 patients Regulation qRT-PCR//Microarray All patients with COVID-19 displayed lymphopenia, especially in T cells, and hyper-inflammatory responses, including IL-6 and TNF-α. Four immune-related lncRNAs in COVID-19 were found and further validated, including AC136475.9, CATG00000032642.1, G004246, and XLOC_013290. No 35573725 XLOC_013994_2 LncRNA Homo sapiens Sepsis blood Expression[lower expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 ZBTB8OS CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 XLOC_078623 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[lower expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 ZBTB7B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ZBTB7A LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Interaction[miR-663a-ZBTB7A-LncRNAGAS5 pathway] qRT-PCR//Luciferase Report Assay//Microarray//IHC//ChIP ZBTB7A expression levels were increased in osteosarcoma tissues and elevated ZBTB7A was associated with osteosarcoma metastasis. Collectively, our findings reveal the prosurvival role of ZBTB7A in osteosarcoma adaptation to ER stress and suggest that the miR-663a-ZBTB7A-LncRNAGAS5 pathway is essential for the survival of human osteosarcoma cells under ER stress. No 30753838 ZBTB44-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 YWHAZP4 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 700 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 YWHAZ-212 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 YWHAE LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Regulation[K-Ras/Erk1/2 and PI3K/Akt signaling pathways] Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//RNA-seq RNA-seq analysis showed that YWHAE gene is upregulated in colorectal cancer specimens.Additionally, bioinformatics analysis suggested that YWHAE lncRNA sponges miR-323a-3p and miR-532-5p that were predicted to target K-Ras 3'UTR sequence. Overexpression of YWHAE lncRNA resulted in upregulation of K-Ras gene expression, while overexpression of both miR-323a-3p and miR-532-5p had an inverse effect, detected by RT-qPCR. Consistently, western blot analysis confirmed that YWHAE lncRNA overexpression upregulated K-Ras/Erk1/2 and PI3K/Akt signaling pathways, while miR-323a-3p and miR-532-5p overexpression suppressed both pathways in HCT116 cells. Furthermore, dual luciferase assay validated the direct interaction of miR-323a-3p and miR-532-5p with K-Ras 3'UTR sequence and supported the sponging effect of YWHAE lncRNA over both miRNAs. These results suggested YWHAE lncRNA as an oncogene that exerts its effect through sponging miR-323a-3p and miR-532-5p and in turn, upregulates K-Ras/Erk1/2 and PI3K/Akt signaling pathways. Consistently, flow cytometry analysis, MTT assay and measuring cyclin D1 gene expression, confirmed the cell cycle stimulatory effect of YWHAE lncRNA, while miR-323a-3p and miR-532-5p showed an inhibitory effect on cell cycle progression. Finally, wound-healing assay supported the cell migratory effect of YWHAE lncRNA in HCT116 cells. This study identified a novel mechanism involving YWHAE-encoded lncRNA, miR-323a-3p and miR-532-5p in regulating HCT116 cell survival and suggested a potential therapeutic avenue for colorectal cancer. No 31238337 YTHDF3 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 YPEL1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 YIPF2 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 YES1P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 685 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 YBX3-213 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 Y5 LncRNA Homo sapiens Depressive Disorder, Major blood Expression[highly expressed] qRT-PCR Five were found to be differentially expressed in MDD patients compared to healthy subjects (Fig. 1, Supplemenatal Table 3): MER11C, PCAT1, PCAT29, RMRP, and Y5. Whereas the expression level of RMRP in MDD patients was significantly lower than in healthy subjects (p = 0.000227, U = 175), the expression levels of MER11C, PCAT1, PCAT29, and Y5 were significantly higher in MDD patients than in healthy subjects (MER11C: p = 0.0215, U = 262; PCAT1: p = 0.0183, U = 199; PCAT29: p = 0.00693, U = 165; Y5: p = 0.00665, U = 226). No 31351391 XRCC5 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 XR_928709.2 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 XR_600374 LncRNA Mus musculus Chronic Intermittent Hypoxia heart tissues Expression[lower expressed] qRT-PCR "To validate the reliability of our microarray results, three upregulated lncRNAs (XR_596701, XR_344474, and ENSRNOT00000065561) and three downregulated lncRNAs (XR_600374, XR_590196, and XR_597099) were randomly selected to perform qRT-PCR verification in same RNA samples used for the microarray analyses. To our interesting, the qRT-PCR results were in agreement with the microarray findings, which demonstrated the same trends of up- or downregulation for each differentially expressed lncRNA (Fig. 6). " No 30535531 XR_596701 LncRNA Mus musculus Chronic Intermittent Hypoxia heart tissues Expression[highly expressed] qRT-PCR "To validate the reliability of our microarray results, three upregulated lncRNAs (XR_596701, XR_344474, and ENSRNOT00000065561) and three downregulated lncRNAs (XR_600374, XR_590196, and XR_597099) were randomly selected to perform qRT-PCR verification in same RNA samples used for the microarray analyses. To our interesting, the qRT-PCR results were in agreement with the microarray findings, which demonstrated the same trends of up- or downregulation for each differentially expressed lncRNA (Fig. 6). " No 30535531 XR_590196 LncRNA Mus musculus Chronic Intermittent Hypoxia heart tissues Expression[lower expressed] qRT-PCR "To validate the reliability of our microarray results, three upregulated lncRNAs (XR_596701, XR_344474, and ENSRNOT00000065561) and three downregulated lncRNAs (XR_600374, XR_590196, and XR_597099) were randomly selected to perform qRT-PCR verification in same RNA samples used for the microarray analyses. To our interesting, the qRT-PCR results were in agreement with the microarray findings, which demonstrated the same trends of up- or downregulation for each differentially expressed lncRNA (Fig. 6). " No 30535531 XR_344474 LncRNA Mus musculus Chronic Intermittent Hypoxia heart tissues Expression[highly expressed] qRT-PCR "To validate the reliability of our microarray results, three upregulated lncRNAs (XR_596701, XR_344474, and ENSRNOT00000065561) and three downregulated lncRNAs (XR_600374, XR_590196, and XR_597099) were randomly selected to perform qRT-PCR verification in same RNA samples used for the microarray analyses. To our interesting, the qRT-PCR results were in agreement with the microarray findings, which demonstrated the same trends of up- or downregulation for each differentially expressed lncRNA (Fig. 6). " No 30535531 XR_001746974.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 XR_001745030.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 XR_001744641.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 XPO5 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 XPO5 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 XLOC_324131 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 XLOC_167004 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[highly expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 XLOC_163714 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 XLOC_163712 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 XLOC_109948 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow and serum Expression[highly expressed] qRT-PCR The expression of LncRNA XLOC_109948 in bone marrow and serum of AML patients was higher than that of AML patients with complete remission and healthy people (P<0.001). The expression of LncRNA XLOC_109948 in bone marrow and serum of AML patients was higher than that of AML patients with complete remission and healthy people (P<0.001). No 33067951 XLOC_102167 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[highly expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 U3 LncRNA Homo sapiens Myelodysplastic Syndromes bone marrow Expression[lower expressed] qRT-PCR//Microarray Of the functionally described lncRNAs, we detected the upregulation of H19, EMCN-IT1, WT1-AS, MEG8, and PVT1 and the downregulation of ST6GAL2-IT1 and U9. No 32977510 TYMSOS LncRNA Homo sapiens Osteosarcoma OS cells Interaction(TYMSOS-miR-101-3p-NETO2 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay In addition, our study proved that TYMSOS promotes the malignancy of OS via elevating NETO2 expression as miR-101-3p sponge. No 36509232 TCONS_l2_00024431 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 THSD4-AS2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 THRIL LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[lower expressed] qRT-PCR HULC, OIP5-AS1 and THRIL transcription quantities were significantly lower in gastric tumors compared to ANCTs (P values = .02, 0.02 and 0.007, respectively). No 31982396 THRIL LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[lower expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 THRIL LncRNA Homo sapiens Inflammatory Bowel Diseases UC patients Interaction(MiR-125b) qRT-PCR Our results showed a significant increase in the fold change of LncRNA THRIL in UC patients (Median = 11.11, IQR; 10.21-12.45, P<0.001) and CD patients (Median = 5.87, IQR; 4.57-7.88, P<0.001) compared to controls. Furthermore, there was a negative significant correlation between LncRNA THRIL and MiR-125b in UC patients (r = -0.28, P = 0.016) and in CD patients (r = -0.772, P<0.001). ROC curve analysis was done showing the diagnostic value of these markers as predictors in differentiating between cases of UC, CD, and control. No 36206229 THRIL LncRNA Homo sapiens Arthritis, Rheumatoid blood Expression[highly expressed] qRT-PCR The results indicate that T cells of RA patients display increased levels of GAS5 (3.31-fold, p = 0.007), RMRP (2.43-fold, p = 0.02), and THRIL (2.14-fold, p = 0.03) lncRNAs compared with those of controls. No 31346885 THRIL LncRNA Homo sapiens Arthritis, Rheumatoid serum regulation[PI3K/AKT Signals] qRT-PCR//ELISA//MTT The qRT-PCR analysis was employed for evaluating the levels of THRIL in the serum.The present study revealed that THRIL could regulate cell growth and inflammatory response of FLSs by activating the PI3K/AKT signaling pathway, subsequently playing important roles in promoting the occurrence and development of RA. No 32232711 THRIL LncRNA Homo sapiens Respiratory Distress Syndrome blood Expression[highly expressed] qRT-PCR Lnc-THRIL was upregulated in ARDS group compared with non-ARDS group, and it had good value in distinguishing ARDS from non-ARDS in sepsis patients (AUC: 0.706; 95%CI: 0.602-0.809). THRIL positively correlated with APACHE II score and SOFA score in sepsis patients. Regarding inflammation, lnc-THRIL was positively associated with CRP, PCT, TNF-α, and IL-1β levels in sepsis patients. Additionally, the mortality rate was 30.2%, and lnc-THRIL was upregulated in non-survivors compared with survivors, presenting a good value (AUC: 0.780; 95%CI: 0.683-0.876) in predicting mortality in sepsis patients. No 31257645 THRIL LncRNA Homo sapiens Coronary Disease blood Expression[highly expressed] qRT-PCR Both before and after adjustment by age/gender, lncRNA THRIL was increased in CHD patients compared with control subjects (both P < .001), and it well predicted enhanced CHD risk by receiver operating characteristic curves. No 31944373 THRIL LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 THRIL LncRNA Homo sapiens COVID-19 Peripheral Blood Mononuclear Cell Expression(highly expressed) qRT-PCR The mean expression levels of MALAT-1, THRIL, and miR-155-5p were significantly increased in the acute phase of COVID-19 compared with a healthy control group. In addition, the expression levels of MALAT-1 and THRIL in the post-acute phase of COVID-19 were significantly lower than in the acute phase of COVID-19. According to the ROC curve analysis, these ncRNAs could be considered useful biomarkers for COVID-19 diagnosis and for discriminating between acute and post-acute phase of COVID-19. No 35500644 THORLNC LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues interaction[SOX9 ] qRT-PCR//Luciferase Report Assay//RIP//Western Blot RNA-sequencing combined with quantitative real-time PCR (qRT-PCR) indicated that lncRNA THOR level was significantly upregulated in gastric cancer tissues compared with that in normal adjacent tissues.Thus, our results suggest that THOR could potentiate the stemness of gastric cancer cells via directly binding to SOX9 3'UTR. No 30227327 THORLNC LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck TSCC tissues Regulation[THOR/IGF2BP1/IGF2-MEK-ERK axis] Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Colony Formation Assay We discovered that THOR and IGF2BP1 were dramatically upregulated in TSCC tissues.The expression of THOR is positively correlated with IGF2BP1 mRNA level. THOR mediated IGF2 expression via interacting with IGF2BP1, and affected the downstream MEK-ERK signaling pathway to regulate TSCC cells proliferation. THOR/IGF2BP1/IGF2-MEK-ERK axis regulated the proliferation of TSCC cells, implying that THOR would be a promising therapeutic target for TSCC patients. No 31220513 THC2686626 LncRNA Homo sapiens Arthritis, Gouty blood Expression[highly expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 TGFBR2 LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-15A) Expression[highly expressed] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD9 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 TGFBR2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC and para-carcinoma tissues Expression[Expression[lower expressed]-expression] qRT-PCR//Microarray The qRT-PCR assay showed the Expression[Expression[up-expression]-expression]regulation of miR-455-5p, miR-21-3p, miR-96-5p, miR-93-5p, RP11-973H7.5, and HOXC10 expression in LSCC as well as the Expression[down-expression]regulation of miR-486-5p, LINC00657, CTC-297N7.9, hsa_circ_0008832, hsa_circ_0033988, hsa_circ_0001445, hsa_circ_0007013, KRT4, HOPX, TGFBR2, and KDR expression in LSCC (Fig. 12). No 30128795 TGFB2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TFDP1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] qRT-PCR We found that lnc-DILC expression was downregulated in CRC tissues compared to their adjacent normal tissues (p<0.01). ROC analyses showed that lnc-DILC levels were reliable in distinguishing patients with CRC from normal colorectal tissues. Then, down-regulation of lnc-DILC was positively associated with aggressive clinical characteristics, including depth of invasion (p=0.018) and advanced TNM stage (p=0.009). Moreover, the Kaplan-Meier analysis demonstrated that overexpression of lnc-DILC was associated with poorer overall survival (p=0.0205) and disease-free survival (p<0.001). No 31081085 TFDP1 LncRNA Homo sapiens Osteoarthritis blood Interaction[regulates IL-6 ] qRT-PCR We found that lncRNA DILC was downregulated, while IL-6 was upregulated in plasma of osteoarthritis patients comparing to the control group.Therefore, lncRNA DILC is downregulated in osteoarthritis and regulates IL-6 expression in chondrocytes. No 31069838 TFDP1 LncRNA Homo sapiens Arthritis, Rheumatoid blood Interaction[ down-regulating IL-6] qRT-PCR n the present study, we found that plasma lncRNA DILC was down-regulated, while IL-6 was up-regulated in RA patients than in healthy controls. No 30944206 TFAP2A-AS1 LncRNA Homo sapiens Breast Neoplasms TCGA and breast cancer cells Expression [highly expressed] qRT-PCR The qRT-PCR identified 5 lncRNAs with significantly differential expression in breast cancer cells based on the 9 lncRNAs of the prognostic model, and the results were consistent with the tissues. No 33614483 TEX41-379 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TEX41-325 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TERF2IPP1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 869 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 TERC LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)115) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 TERC LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TERC LncRNA Homo sapiens bladder urothelial carcinoma BLCA patients Expression(highly expressed) qRT-PCR//RNA-seq//Western Blot We found that TERC was significantly upregulated in urinary exosomes from BLCA patients compared with those from healthy controls (P < 0.0001). No 35127956 TECR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TDRG1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues,cell lines( SiHa, C33A, CaSki, and Hela) Interaction[miR-330-5p/ELK1] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay LncRNA TDRG1 expression was notably increased in cervical cancer tissues and cancer cells.echanism investigation suggested that lncRNA TDRG1 Expression[Expression[up-expression]-expression]-regulated the expression of ELK1 by acting as a competing endogenous RNA (CeRNA) of miR-330-5p. Rescue experiments indicated that miR-330-5p-inhibitor reversed the si-TDRG1-induced cell activity changes. This in vivo study proved that the Expression[down-expression]-regulation of lncRNA TDRG1 inhibited cervical tumor growth by regulating miR-330-5p/ELK1. No 31539116 TCONS_l2_00030859 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00030826 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 THSD4-AS2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 718 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 THUMPD3-AS1-217 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR Finally, three lncRNAs, including ENST00000522221, lnc‑HACE1‑6:1 and lnc‑ICOSLG‑11:1, are significantly upregulated in HCC tissues compared with adjacent tumor‑free tissues. No 31485608 TCONS_l2_00030633 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TIMELESS LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TMEM18-DT LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 TMEM139 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TMEM138 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TMEM134 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TMEM132D-AS1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 TMEM131-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 TMEM108-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TMEM108-AS1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 TMCO5B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TMCO1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue Expression(highly expressed) qRT-PCR Bioinformatics analysis showed the aberrant high expression of TMCO1-AS1 in HCC tissue. TMCO1-AS1 expression was positively correlated with alpha-fetoprotein (AFP) level, vascular invasion, tumor stage, as well as tumor differentiation. Moreover, survival analysis found a significant inverse association between the expression of TMCO1-AS1 and the survival of patients with HCC. No 35141283 TMC6 LncRNA Homo sapiens Thyroid Neoplasms thyroid carcinoma tissues Interaction[Hippo signalling pathway] Western Blot//FISH//RIP//Microarray//EdU Staining//ChIP LncRNA TNRC6C-AS1 promoted the STK4 methylation and down-regulated STK4 expression, which further activated the Hippo signalling pathway. No 31657132 TMC6 LncRNA Homo sapiens Thyroid Neoplasms Regulation[Hippo signalling pathway ] Western Blot//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//IF TNRC6C-AS1 was up-regulated while STK4 was down-regulated, where methylation level was elevated. Based on our observations, we subsequently confirmed the anti-proliferative, pro-apoptotic and pro-autophagy capabilities of TNRC6C-AS1 through STK4 methylation via the Hippo signalling pathway in TC. No 30938030 TMA16 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 TM4SF1-AS1 LncRNA Homo sapiens Cholangiocarcinoma 107 pairs of tumor and paracancer tissues Interaction(miR-744-3p) qRT-PCR//Luciferase Report Assay//Invasion Assay//Migration Assay The elevated expression of TM4SF1-AS1 and the declined expression of miR-744-3p were observed in CCA. TM4SF1-AS1 was suggested to act as a tumor promoter of CCA, where miR-744-3p was found to mediate the function of TM4SF1-AS1. Both TM4SF1-AS1 and miR-744-3p were found to possess a close association with the malignant progression and poor prognosis of CCA patients. No 35346892 TM4SF19-DYNLT2B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TM4SF19-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TM2D1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TLX1NB LncRNA Homo sapiens Colorectal Neoplasms The paired tumor and adjacent normal samples from thirty colorectal cancer patients Expression [highly expressed] Bioinformatics Analysis Then, we validated the overexpression of two first-ranked lncRNAs, i.e., NPSR1-AS1 and TLX1NB, in our in-house colorectal cancer samples as compared to the paired adjacent normal tissues. No 34406628 TLK2P2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 694 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 TLCD4 CircRNA Homo sapiens Cardiomyopathy, Hypertrophic blood Expression[lower expressed] qRT-PCR Serum expression levels of circRNAs DNAJC6, TMEM56 and MBOAT2 were downregulated in patients with HCM. No 31889077 TINCR LncRNA Homo sapiens Thyroid Cancer, Papillary Blood samples Mutation(rs8101923, ) qRT-PCR//Colony Formation Assay//ChIP The impact of the rs8101923 on TINCR expression and enhancer activity was evaluated by quantitative real-time PCR and dual-luciferase reporter assay. The binding of AP-2α to TINCR enhancer was determined by chromatin immunoprecipitation. The rs8101923 G allele was significantly associated with a higher risk of PTC (adjusted OR = 1.37; 95% CI: 1.15-1.64). Mechanistically, the rs8101923 was related to increased transcriptional levels and enhancer activities (P < 0.05). Transcription factor AP-2α binds to the enhancer region of TINCR containing the rs8101923 locus, and promotes cell proliferation in PTC. No 35489191 TINCR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction( TCPTP and suppressed the dephosphorylation of STAT3) CCK8//qRT-PCR//Western Blot Our data revealed that TINCR directly bound TCPTP and suppressed the dephosphorylation of STAT3, thus promoting STAT3 activation and its downstream target genes in HCC progression and tumorigenicity.HighlightsLncRNA TINCR interacted with protein TCPTPLncRNA TINCR maintained STAT3 phosphorylationLncRNA TINCR affected STAT3 signaling in HCC No 34057016 TINCR LncRNA Homo sapiens Urinary Bladder Neoplasms Bladder Cancer tissues Mutation[rs2288947 A>G,rs8113645 C > T] qRT-PCR//Luciferase Report Assay The lncRNA TINCR rs2288947 A>G is associated with increased bladder cancer risk and rs8113645 C > T is associated with decreased susceptibility. These two SNP loci are associated with lncRNA TINCR expression levels; however, further studies are needed for validation. No 33372851 TINCR LncRNA Homo sapiens Triple Negative Breast Neoplasms blood Expression[highly expressed] qRT-PCR The results showed that serum lncRNA TINCR level was significantly increased in BC, especially in TNBC. High circulating lncRNA TINCR was significantly correlated with worse clinicopathological features and clinical outcome of TNBC. Multivariate analysis revealed that serum lncRNA TINCR was an independent prognostic factor for overall survival of TNBC. However, little association was found between serum lncRNA TINCR and the prognosis of non-TNBC. No 33084530 TINCR LncRNA Homo sapiens Abortion, Habitual blood Mutation[rs2288947 ] Genotyping Therefore, we investigated the relationship between the rs2288947 A > G polymorphism of the lncRNA TINCR and susceptibility to recurrent abortion. We recruited 248 recurrent spontaneous abortion patients and 392 healthy control subjects from the Southern Chinese population and used the TaqMan method for genotyping. There was no evidence that this polymorphism is associated with recurrent miscarriage (AG vs AA: adjusted OR = 0.904, 95% CI = 0.647-1.264, P = 0.5552; GG and AA: adjusted OR = 0.871, 95% CI = 0.475-1.597, P = 0.6542; dominant model: AG/GG vs AA: adjusted OR = 0.898, 95% CI = 0.653-1.236, P = 0.5101; and recessive model: GG vs AA/AG: adjusted OR = 0.910, 95% CI = 0.505-1.639, P = 0.7527). The stratified analysis also showed no significant associations. This study suggests that the rs2288947 A > G polymorphism of the lncRNA TINCR may not be associated with recurrent miscarriage in a Southern Chinese population. No 31124188 TINCR LncRNA Homo sapiens Carcinoma, Ductal, Breast Plasma Expression[highly expressed] qRT-PCR Plasma TINCR, HOTTIP, and SPRY4-IT1 upregulation and ANCR downregulation were observed in SSc patients compared with controls. No 32442909 TIMM8B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TIMM23 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00030797 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00030559 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TMEM254-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029048 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00028855 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00028808 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00028800 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00028766 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00028765 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00028738 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00028612 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00028293 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00028290 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00027829 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00027748 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00027398 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00027286 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00027281 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00027270 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00027019 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00026970 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00026770 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00026705 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00026657 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00026417 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00026039 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00026004 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00025980 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00025979 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00025932 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00025639 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00024745 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00024567 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00028987 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029052 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00030495 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029077 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00030333 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00030309 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00030232 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00030193 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00030183 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00030085 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029982 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029966 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029951 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029741 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029507 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029481 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029454 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029386 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029375 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029368 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029367 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029360 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029355 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029346 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029344 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029343 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029334 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029333 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029332 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029330 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029318 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029293 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TCONS_l2_00029098 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TMEM238L LncRNA Homo sapiens Colorectal Neoplasms Tumor and tumor-free surrounding tissue samples were obtained from 51 CRC cases Expression(highly expressed) qRT-PCR LINC00675 levels were found to be approximately three times higher in colon tumors than tumors with rectal involvement (p=0.019). No 35220220 TMEM39A LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TXNL1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TUG1 LncRNA Homo sapiens Leukemia, Myeloid, Acute regulation[up-regulated] Meta-analysis Abnormally expressed lncRNAs are significantly related to worse prognoses of AML patients and might serve as potential prognostic markers to predict the prognosis of AML patients. No 33346694 TUG1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC cells and exosomal Expression[highly expressed] qRT-PCR Initially, it was found that TUG1 expression was upregulated in both CC cells and their secreted exosomes. No 32432954 TUG1 LncRNA Homo sapiens Multiple Myeloma blood Expression[highly expressed] qRT-PCR We analyzed serum TUG1 levels via quantitative real-time polymerase chain reaction in healthy control and MM patient serum and observed clear TUG1 upregulation in MM patients (p < 0.001). No 31647962 TUG1 LncRNA Homo sapiens Lupus Erythematosus, Systemic blood Expression[lower expressed] qRT-PCR As compared to healthy controls, SLE patients manifested a lower expression of TUG1 in PBMCs, which was further decreased in SLE patients with lupus nephritis (P < .05). No 31944629 TUG1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] CCK8//qRT-PCR LncRNA TUG1 expression was elevated in tumor tissue compared with paired adjacent tissue (P<0.001). Moreover, lncRNA TUG1 expression in tumor tissue positively correlated with pathological T stage (P=0.009) and lymph node metastasis (P=0.040). Patients with a high expression of lncRNA TUG1 had both worse disease-free survival (DFS) (P<0.001) and overall survival (OS) (P=0.003) compared with patients with a low expression of lncRNA TUG1. Multivariate Cox's proportional hazards regression analysis revealed that high lncRNA TUG1 expression was an independent predicting factor for both worse DFS (P=0.001) and OS (P=0.003). No 35116932 TUG1 LncRNA Homo sapiens Prostatic Neoplasms Pca samples Expression[highly expressed] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay The levels of lncRNA TUG1 and SMC1A were remarkably increased, while miR-139-5p was downregulated in PCa. No 32256083 TUG1 LncRNA Homo sapiens Diabetes Mellitus, Type 2 101 pairs of T2DM and controls Expression(highly expressed) qRT-PCR Compared with healthy controls, the expression levels of hsa_circ_0071106, hsa_circ_0000284, hsa_circ_0071271, hsa-miR-29a-5p, hsa-miR-3690, hsa-miR-607, lncRNA MEG3 and lncRNA TUG1were higher in T2DM (all P < 0.05). The AUCs of hsa_circ_0071106, hsa-miR-607 and lncRNA TUG1 for diagnosis of T2DM were 0.563,0.645 and 0.642, respectively. No 35876150 TUG1 LncRNA Homo sapiens Multiple Sclerosis peripheral blood Expression[highly expressed] qRT-PCR In the present study, we evaluated expression levels of three lncRNAs named Nuclear Paraspeckle Assembly Transcript 1 (NEAT1), P21 associated ncRNA DNA damage activated (PANDA) and Taurine-up-regulated gene 1 (TUG1) in peripheral blood of 50 relapsing-remitting MS patients and 50 matched healthy subjects. No 30114626 TUG1 LncRNA Homo sapiens bladder urothelial carcinoma UCB tissues and cell lines Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Nrf2 and TUG1 were upregulated in UCB tissues and cell lines. No 31308746 TUG1 LncRNA Homo sapiens Sepsis blood Expression[lower expressed] qRT-PCR LncRNA TUG1 expression was decreased (P < .001) but miR-223 expression (P < .001) was elevated in sepsis patients. No 33327275 TUG1 LncRNA Homo sapiens Sepsis Plasma interaction[miR-27a ,TNF-α] qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Western Blot TUG1 was downregulated in patients with sepsis. We conclude that TUG1 is downregulated in sepsis and may act as a molecular “sponge” of miR-27a to downregulate TNF-α. No 32237949 TUG1 LncRNA Homo sapiens Polycystic Ovary Syndrome follicles Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//FISH We found that TUG1 levels were dramatically increased in the PCOS group compared with those of the control group; this increased expression was related to a rising antral follicle count (R = 0.209, P < 0.001 versus control). No 32559120 TUG1 LncRNA Homo sapiens Bipolar Disorder blood Expression[highly expressed] qRT-PCR CCAT2, TUG1 and PANDA were up-regulated in total BD patients compared with total healthy subjects (P values = 0.006, <0.001 and 0.004 respectively) while OIP5-AS1 was down-regulated (P = 0.001). No 30772744 TUG1 LncRNA Homo sapiens Heart Failure patients with CHF Interaction(miR-145-5p ) qRT-PCR The results indicated that TUG1 was upregulated and miR-145-5p was downregulated in patients with CHF and they were negatively correlated. TUG1 and miR-145-5p were associated with the left ventricle ejection fraction and were able to indicate the severity of CHF. Serum TUG1 and miR-145-5p had a certain diagnostic value and the combination of BNP, TUG1 and miR-145-5p had high diagnostic accuracy. TUG1 and miR-145-5p were closely associated with overall survival and may function as independent prognostic biomarkers for patients with CHF. No 34659508 TUG1 LncRNA Homo sapiens Precursor Cell Lymphoblastic Leukemia-Lymphoma BM samples of Ph− ALL patients Expression [highly expressed] qRT-PCR LncRNA TUG1 was upregulated in Ph ALL patients compared with healthy donors. Further analysis indicated that in Ph ALL patients, higher lncRNA TUG1 tier was correlated with the presence of central nervous system leukemia, increased white blood cell level, and bone marrow blasts. Furthermore, higher lncRNA TUG1 tier was negatively associated with complete remission (CR) within 4 weeks, total CR, and allogeneic hematopoietic stem cell transplant achievement. In addition, higher lncRNA TUG1 tier was associated with decreased disease-free survival and overall survival, which was further verified to be an independent factor by Cox's regression analysis. -- In addition, higher lncRNA TUG1 tier was associated with decreased disease-free survival and overall survival, which was further verified to be an independent factor by Cox's regression analysis. -- No 34251066 TUG1 LncRNA Homo sapiens Renal Insufficiency, Chronic CHF patients Expression(lower expressed) qRT-PCR TUG1 was lowly expressed in CHF patients and was further downregulated in CHF patients complicated with progressive CKD. ROC curve analysis showed that plasma TUG1 expression levels could be used to distinguish CHF patients complicated with CKD from CHF patients without CKD and healthy controls. No 34846690 TUG1 LncRNA Homo sapiens Osteoarthritis, Knee 255 KOA patients and 255 control subjects Mutation(rs5749201, rs7284767, rs886471 ) qRT-PCR//Genotyping we found that the carriers of the A allele of the TUG1 rs5749201 locus were 1.36 times more likely to develop KOA than the carriers of the T allele (95% confidence interval [CI] = 1.05-1.75, p = 0.02); the G allele of the rs7284767 locus was a protective factor for KOA (odds ratio [OR] = 0.71, 95% CI = 0.54-0.92, p = 0.01); and the allelic variation at rs886471 G > T led to an increased risk of KOA by 2.34 times (95% CI = 1.53-3.57, p < 0.01). We also found that the GAG haplotype for the three loci was significantly associated with the increased risk of KOA (OR = 2.77, 95% CI = 1.67-4.57, p < 0.01). No 33596137 TUG1 LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 TUG1 LncRNA Homo sapiens COVID-19 80 COVID-19 patients Expression(highly expressed) qRT-PCR NEAT1 and TUG1 expression levels were higher in COVID-19 patients compared with controls (P<0.001). No 35982898 TUG1 LncRNA Homo sapiens Irritable Bowel Syndrome 42 diabetic patients, 42 diabetic patients with IBS, and 42 healthy controls Expression(lower expressed) qRT-PCR H19 and TUG1 were downregulated in patients with poor glycemic control. Diabetic patients with IBS had significantly lower levels of lncRNA H19 and TUG1 expression than healthy controls and diabetic-only patients. H19 and TUG1 were downregulated in patients with poor glycemic control. lncRNA H19 and TUG1 expression in diabetic patients with IBS significantly negatively correlated with the IBS severity scoring system. Both lncRNAs’ expression significantly predicted the disease severity. No 36428545 TUG1 LncRNA Homo sapiens Sars-Cov-2 Vaccination Breakthrough Infections 57 VBT and unvaccinated COVID-19 patients Expression(lower expressed) RNA-seq//Bioinformatics Analysis Further, out of the 12 lncRNA genes, 7 lncRNAs are reported to modulate immune/inflammatory responses in infectious diseases. Out of the 7 lncRNAs, LUCAT1, MALAT1, NEAT1 and GAS5 were downregulated in the VBT. LUCAT1 is a negative regulator of interferon response, and downregulation of LUCAT1 suggests an activated interferon response (30). MALAT1 is known to negatively regulate the immune response and positively regulate the inflammatory response in the infected individuals, therefore downregulation of MALAT1 in the breakthrough infection suggests an upregulated immune response and downregulated inflammatory response (31, 32). NEAT1 and GAS5 also act as pro-inflammatory lncRNAs, and their downregulation is an indicator of decreased inflammatory response in the VBT (33, 34). Amongst the upregulated lncRNAs, ROR1-AS1, UGDH-AS1 and LINC00273 were upregulated in the VBT. The upregulation of ROR1-AS1 and LINC00273 indicates a heightened immune response, whereas upregulation of UGDH-AS1 suggests a decreased disease severity possibly modulated by MOV10 and EDN1 (8). No 36466827 Tug1 LncRNA Mus musculus Asthma mouse airway tissues Interaction(microRNA-181b/HMGB1 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay To conclude, this study evidenced that lncRNA TUG1 reinforces HMGB1 expression through sequestering microRNA-181b, which activates the NF-κB signaling pathway and promotes airway remodeling in asthmatic mice. No 33640857 TTTY15 LncRNA Homo sapiens Colorectal Neoplasms cancerous tissues Interaction(miR-29a-3p/DVL3 axis) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay TTTY15 was significantly up-regulated in cancerous tissues of colorectal cancer samples, positively correlated with the expression of DVL3, while negatively correlated with the expression of miR-29a-3p. No 33016900 TTTY15 LncRNA Homo sapiens acute myocardial infarction 80 AMI patients and 36 healthy volunteers Regulation qRT-PCR ROC analysis reveals the superiority of TTTY15 and HULC as biomarkers against conventional AMI biomarkers CKMB (AUC of TTTY15: 0.915 versus CKMB: 0.768 versus TnT: 0.869); AUC of HULC: 0.905 versus CKMB: 0.768 versus TnT: 0.869). Regression and correlation analysis indicates that TTTY15 and HULC may be one of the contributing factors to AMI and related to accepted risk factors. ROC analysis reveals the superiority of TTTY15 and HULC as biomarkers against conventional AMI biomarkers CKMB (AUC of TTTY15: 0.915 versus CKMB: 0.768 versus TnT: 0.869); AUC of HULC: 0.905 versus CKMB: 0.768 versus TnT: 0.869). Regression and correlation analysis indicates that TTTY15 and HULC may be one of the contributing factors to AMI and related to accepted risk factors. No 35246050 TTTY14 LncRNA Homo sapiens Colorectal Neoplasms colorectal tumors Expression [lower expressed] Bioinformatics Analysis Our results nominated ESRG, LINC00518, PWRN1, and TTTY14 lncRNAs as the top-hit novel lncRNAs with aberrant expression in colon cancer. The qPCR method was used to profile these lncRNAs that showed the up-regulation of ESRG and LINC00518, and down-regulation of TTTY14 in thirty paired colorectal cancer specimens. No 34896077 TTN-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 501 HNSCC tumor samples Regulation Bioinformatics Analysis The Prognostic Signature is based on 10 cuproptosis-related lncRNAs including AC090587.1, AC004943.2, TTN-AS1, AL162458.1, AC106820.5, AC012313.5, AL132800.1, WDFY3-AS2, CDKN2A-DT, and AL136419.3. The results of overall survival, risk score distribution, and survival status in the low-risk group were better than those in the high-risk group. In addition, all immune checkpoint genes involved were significantly different between the two risk groups (p < 0.05). The risk score was positively correlated with Eosinophils. M0 and M2 phenotype macrophages, mast cells activated, NK cells activated, and negatively related with B cells naive, mast cells resting, plasma cells, CD8T cells, T cells follicular helper, T cells regulatory (Tregs). No 35942287 TTN-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Expression[highly expressed] CCK8//qRT-PCR//Western Blot The lncRNA TTN-AS1 was highly expressed in osteosarcoma and was associated with poor prognosis. No 31600142 TTN-AS1 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues Interaction(miR-133b/SQLE axis) In Vivo Experiment//IHC//Western Blot//ISH//Transfection//Wound Healing Assay//Migration Assay//Luciferase Report Assay//Microarray//Colony Formation Assay//Invasion Assay LncRNA-TTN-AS1 was upregulated in pancreatic cancer tissues and positively correlated with the expression of SQLE. Luciferase gene reporter gene analysis confirmed lncRNA-TTN-AS1 directly binded to miR-133b. Therefore, we propose that targeting the lncRNA-TTN-AS1/miR-133b/SQLE axis is expected to provide new ideas for the clinical treatment of PC patients. No 35638462 TTLL3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TUG1 LncRNA Homo sapiens pancreatic ductal adenocarcinoma pancreatic cancer tissue and cells Expression[highly expressed] qRT-PCR//Wound Healing Assay//Western Blot//Transwell Assay Compared with normal tissues and cells, the expression of TUG1 was up-regulated in pancreatic cancer tissue and cells. No 29960845 TUG1 LncRNA Homo sapiens Leukemia, Myeloid, Acute cell lines( HL-60,Kasumi-1) Interaction[miR-370-3p/MAPK1/ERK] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Knockdown of TUG1 markedly reduced viability and metastasis of AML cells, while its overexpression had the opposite effect. MAPK1 was verified as a target gene of miR-370-3p. TUG1 could reduce the level of functional miR-370-3p, facilitate MAPK1 expression, and in turn activate ERK1/2 signaling. No 31819520 TTC7A-214 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TUG1 LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis Our meta-analysis revealed that a high expression of the lncRNA TUG1 was significantly associated with poor prognosis in patients with various cancers. Therefore, lncRNA TUG1 could be considered as a potential prognostic factor in different cancer types. No 30549987 TXNIP-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 TXNDC12 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TWF2-202 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 TVP23CP1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1056 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 TUSC7 LncRNA Homo sapiens Stomach Neoplasms 470 gastric cancer tissues Mutation [SNPs (rs12494960, rs1518338, rs2867837) ]/Interaction( miR-133a-3p) qRT-PCR//Luciferase Report Assay//Genotyping Three tagging SNPs (rs12494960, rs1518338, rs2867837) of TUSC7 were selected to validate in population. The unconditional multiple logistic regression showed that individuals with genotype AA (OR: 1.79, 95% CI: 1.16, 2.70) of rs12494960 and GG (OR: 2.24, 95% CI: 1.12, 4.46) of rs2867837 in TUSC7 had increased risk of GC susceptibility. The qRT-PCR showed that CA and AA genotype of rs12494960 in TUSC7 had significantly lower relative expression level in plasma, compared with CC genotype. The dual luciferase reporter assay showed that TUSC7 and miR-133a-3p had interaction. No 33886026 TUSC7 LncRNA Homo sapiens Breast Neoplasms tumor tissues Interaction(TUSC7/miR-211/Nurr1 ceRNET) Genotyping The expression of TUSC7 and Nurr1 significantly decreased, but the level of miR-211 significantly increased in tumor tissues compared to TANTs and healthy normal tissues. Altered expression of TUSC7 and miR-211 was associated with poor prognosis of patients. No 35296964 TUSC7 LncRNA Homo sapiens Lung Neoplasms non-small cell lung cancer Interaction[targeting p53] RNA Pull-Down//Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Invasion Assay The results revealed that the expression of LOC285194 was significantly lower in tumor tissues when compared with the corresponding non-tumor tissues (P<0.001). RNA protein interaction analysis revealed that p53 was the direct binding target of LOC285194 in NSCLC. Bioinformatics analyses suggested that depletion of LOC285149 could affect its antitumor function through the KRAS/BRAF/SMEK pathway. The results revealed that the expression of LOC285194 was significantly lower in tumor tissues when compared with the corresponding non-tumor tissues (P<0.001). Its expression was correlated with the tumor size (P=0.027). Kaplan-Meier analysis revealed that patients with lower LOC285194 expression had worse disease-free survival and overall survival rates (P<0.05). No 30542733 TUSC7 LncRNA Homo sapiens Colorectal Neoplasms Liver Metastatic Colorectal Cancer and adjacent non-cancer liver tissues Expression [lower expressed] PCR We first evaluated expression levels of several lncRNAs in eight excised liver metastases from primary colorectal cancers and found significantly upregulated lncRNAs HOTAIR and MALAT1 along with significantly downregulated LOC285194. A positive signature comprising of high HOTAIR/MALAT1 and low LOC285194 also correlated with progression to higher grade tumors.  No 34307387 TUSC7 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Expression[lower expressed] qRT-PCR The expression level of LOC285194 was significantly lower in tumour tissues and four liver cancer cell lines compared with adjacent normal tissues and normal liver cell line. Furthermore, a low expression of LOC285194 was significantly correlated with advanced tumour stage, microvascular invasion, tumour number and differentiation. Additionally, survival analysis showed that patients with low LOC285194 expression had a significantly worse overall and disease-free survival. No 31494574 TUSC7 LncRNA Homo sapiens Neoplasms Expression[lower expressed] Meta-analysis A total of 14 eligible articles with 1215 patients were included in this meta-analysis. Meta-results revealed that low expression of lncRNA loc285194 was significantly correlated with poorer overall survival (OS; HR = 2.34; 95% CI, 1.78-3.06; P < 0.001) and disease-free survival (DFS; HR = 2.66; 95% CI, 1.95-3.64; P = 0.001) rates in cancer patients. Low lncRNA loc285194 expression was also found to be significantly associated with lymph node metastasis (LNM; OR = 2.17; 95% CI, 1.23-3.83; P = 0.007), and distant metastasis (DM; OR = 2.49; 95% CI, 1.26-4.91; P = 0.009). A total of 14 eligible articles with 1215 patients were included in this meta-analysis. Meta-results revealed that low expression of lncRNA loc285194 was significantly correlated with poorer overall survival (OS; HR = 2.34; 95% CI, 1.78-3.06; P < 0.001) and disease-free survival (DFS; HR = 2.66; 95% CI, 1.95-3.64; P = 0.001) rates in cancer patients. Low lncRNA loc285194 expression was also found to be significantly associated with lymph node metastasis (LNM; OR = 2.17; 95% CI, 1.23-3.83; P = 0.007), and distant metastasis (DM; OR = 2.49; 95% CI, 1.26-4.91; P = 0.009). No 31054796 TUG1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)2) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues We further demonstrated that RP11-555H23.1 expression was significantly correlated with TNM stage (P = 0.038). The area under the ROC curve (AUC) was 0.65, and the specificity and sensitivity were 62% and 81%, respectively. No 30320481 TUG1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[lower expressed] qRT-PCR TUG1 was downregulated in tumoral tissues. No 30957286 TUG1 LncRNA Homo sapiens Breast Neoplasms BC tissues,cell lines Expression[highly expressed] qRT-PCR LncRNA TUG1 was highly expressed in BC tissues and positively associated with Dox resistance in BC cell lines. No 33380806 TUG1 LncRNA Homo sapiens Breast Neoplasms serum Expression(highly expressed) qRT-PCR Increased ANRIL (3.83-fold), TUG1 (7.64-fold), UCA1 (7.82-fold), and HIT (3.31-fold) expressions were observed in breast cancer patients compared to healthy controls. While lncRNA TUG-1 expression was found to be higher in patients with early-stage tumors than those with advanced-stage tumors (p = 0.06), lncRNA ANRIL showed increased expression in patients with PR positive status (p = 0.04). However, we found a significant difference in lncRNA HIT expression in HER-2 positive breast cancer patients compared to HER-2 negative breast cancer patients (p = 0.005). An increase in the expression of serum lncRNAs ANRIL (p < 0.0001), UCA-1 (p = 0.004), and HIT (p < 0.0001) was observed in the distant organ metastatic breast cancer patients. No 35132340 TUG1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung blood Expression[lower expressed] qRT-PCR Five lncRNAs (RMRP, NEAT1, TUG1, MALAT1, and H19) stably expressed in plasma. Differential expression analysis showed that RMRP and TUG1 had significantly lower expression levels in the NSCLC group than in the control group (P = 0.001, Figure 2A, Supplementary Table S2 ). In contrast, NEAT1 and MALAT1 had significantly higher expression levels in the NSCLC group than in the control group (P = 0.022 and 0.002, respectively, Figure 2A, Supplementary Table S2 ). The expression level of H19 showed no significant difference between NSCLC and control groups (P = 0.534, Figure 2A, Supplementary Table S2 ). No 33425713 TUG1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue Expression[lower expressed] ISH//qRT-PCR Compared to NAT, NSCLC tissue has a lower expression level of TUG1. The TUG1 expression further decreases as NSCLC progressed to a later stage, indicating a statistically significant difference (p < 0.01 or p < 0.001). High TUG1 expression is not strongly associated with age, gender, smoking history, or the degree of differentiation of NSCLC (p > 0.05) but exhibits close correlations with tumor size, TNM stage, and lymph node metastasis (p < 0.05). Patients with a higher level of TUG1 expression have a higher survival rate and a longer survival time than those with lower TUG1 expression. The inter-group differences were statistically significant (p < 0.05). No 33073961 TUG1 LncRNA Homo sapiens Colorectal Neoplasms serum exosomes Expression[highly expressed] qRT-PCR In serum exosomes, UCA1 was downregulated, while circHIPK3 and TUG1 were upregulated. No 30195762 TUG1 LncRNA Homo sapiens Colorectal Neoplasms serum regulation[miR-138-5p/ZEB2 axis] Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay TUG1 was up-regulated in CRC, and serum TUG1 could be adopted as a diagnostic marker of CRC, with area-under-the-curve (AUC) larger than 0.8.TUG1 could promote the development of CRC via the miR-138-5p/ZEB2 axis. TUG1 was up-regulated in CRC, and serum TUG1 could be adopted as a diagnostic marker of CRC, with area-under-the-curve (AUC) larger than 0.8. No 32391554 TUG1 LncRNA Homo sapiens Colonic Neoplasms colon cancer specimens Expression(highly expressed) qRT-PCR TUG1expression in the colon cancer specimens was significantly overexpressed (median = 21.50, interquartile range [IQR]: 7.0-209.2; P = 0.001) relative to the noncancerous tissues. Similarly, Kaplan-Meir and Cox multivariate regression analyses showed that TUG1 expression could not predict the overall survival and progression-free survival in colon cancer patients of our population. No 36510991 TUG1 LncRNA Homo sapiens Osteoarthritis cartilages of patients with osteoarthritis Regulation[miR-195/MMP-13 axis] qRT-PCR The expression levels of lncRNA-TUG1 and MMP-13 in cartilages of patients with osteoarthritis were higher than those in cartilages of normal people, while the level of miR-195 decreased in cartilages of patients with osteoarthritis. LncRNA-TUG1 regulates the degradation of extracellular matrix in osteoarthritis via lncRNA-TUG1/miR-195/MMP-13 axis. No 30575896 TUG1 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR CASC2 was downregulated in HCC/HCV patients, whereas TUG1 was overexpressed in relation to HCV and the control group, indicating their antagonistic effect. No 31301261 TUG1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Expression[highly expressed] qRT-PCR A total of four DELs were identified and the most remarkably up-regulated lncRNA was TUG1, which included 12 high-confidence target genes. Moreover, we found that the expression changes of TUG1 and its target genes in different databases, cell lines, and liver cancer tissues were consistent with the prediction. The high expression of TUG1 and its target genes could significantly predict the shorter survival time of HCC patients,. No 36457956 TUG1 LncRNA Homo sapiens Ovarian Neoplasms ovarian tumor tissues Expression[highly expressed] qRT-PCR TUG1 is highly expressed not only in ovarian tumor tissues compared with normal ovarian tissues but also in the chemo-resistant group compared with the sensitive group. No 32189969 TUG1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder tissues Expression[lower expressed] qRT-PCR PV1 was down-regulated in tumor tissues compared with both ANCTs and normal controls (Expression ratios of 0.48 and 0.14; P values of 0.4 and <0.001 respectively). No 31054930 TUG1 LncRNA Homo sapiens Urinary Bladder Neoplasms Bladder Cancer tissues Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay Comparing with that of noncancerous counterparts, the expression of TUG1 was significantly upregulated in bladder cancer tissues (Figure 1B). Additionally, TUG1 expression was correlated with clinical stage, lymphatic metastasis, and patient prognosis. No 30925453 TUG1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] qRT-PCR Expression of UCA1 and TUG1 genes was up-regulated in 54.83 % and 53.12 % OSCC tumors, respectively. No 33410422 TUG1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Expression[highly expressed] qRT-PCR This study shows that the expression of TUG1 in osteosarcoma tissues was significantly higher than that in adjacent normal bone tissues. Upregulation of TUG1 was significantly correlated with the larger tumor size and advanced tumor-node-metastases stage of osteosarcoma patients. Kaplan-Meier curve showed a decreased overall survival time of osteosarcoma patients with high TUG1 expression. No 29970697 TUG1 LncRNA Homo sapiens Osteosarcoma OS tissues Interaction[mediating HIF-1α via miR-143-5p] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//ELISA//Transwell Assay "TUG1 was significantly upregulated in OS tissues and associated with tumour size, distant metastasis, TNM stage, and overall and recurrence-free survival, which further indicated poor prognosis. Dysregulated TUG1 expression could act as an miRNA ""sponge"" to competitively protect the HIF-1α mRNA 3'UTR from miR-143-5p." TUG1 was significantly upregulated in OS tissues and associated with tumour size, distant metastasis, TNM stage, and overall and recurrence-free survival, which further indicated poor prognosis. No 30911001 TTLL1 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 TTC39C-AS1 LncRNA Homo sapiens Alzheimer Disease blood Expression[highly expressed] qRT-PCR//Microarray As shown in Fig. 4, compatible with microarray results, expression of lncRNA lnc-AL445989.1-2, TTC39C-AS1, and LINC01420 is significantly high, and lnc-CSTB-1 and LOC401558 are significantly low in the patient group when compared with control groups. No 32885358 TMEM44-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TP73-AS1 LncRNA Rattus norvegicus Glioma 76 glioma tissue samples Expression(highly expressed) qRT-PCR//Survival Analysis Here, we demonstrated that the long non-coding RNA TP73-AS1 is differentially expressed among gliomas with different clinicopathological features in The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and GEO glioma datasets; high expression of TP73-AS1 was associated with poor clinical features, including age, stage, IDH mutation status, 1p/19q co-deletion status and overall survival. Here, we demonstrated that the long non-coding RNA TP73-AS1 is differentially expressed among gliomas with different clinicopathological features in The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and GEO glioma datasets; high expression of TP73-AS1 was associated with poor clinical features, including age, stage, IDH mutation status, 1p/19q co-deletion status and overall survival. No 33589576 TP53COR1 LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 TP53COR1 LncRNA Homo sapiens Liver Neoplasms cell lines(MHCC97H) Interaction[targeting HIF-1α] CCK8//qRT-PCR//Transwell Assay//Western Blot Compared with that in control group, the lincRNA-p21 mRNA level in observation group was increased significantly (P<0.05). No 31186706 TP53COR1 LncRNA Homo sapiens Leukemia, Lymphocytic, Chronic, B-Cell blood Expression[lower expressed] Flow Cytometry//qRT-PCR LincRNA-p21 was significantly downregulated in CLL patients compared to controls. The downstream proapoptotic targets were significantly downregulated in CLL patients and positively correlated with lincRNA-p21. Low expression of lincRNA-p21 was associated with poor prognostic markers (advanced stages of CLL, del 17p13, ZAP70, and CD38 expression), failure of complete remission, shorter progression free survival, and overall survival. Low lincRNA-p21 expression was independently prognostic for shorter time to treatment. No 32468342 TP53COR1 LncRNA Homo sapiens Systemic Lupus Erythematosus-Associated Diffuse Alveolar Hemorrhage circulating MNCs Expression [highly expressed] Immunoblotting//Tunel//qRT-PCR//Cell Apoptosis Assay//IF Significantly higher lincRNA-p21 levels in MNCs were found in SLE patients than in HC subjects In addition, DAH patients had higher lincRNA-p21 levels than healthy controls (p < 0.001) or those without DAH (p = 0.003). A significant positive correlation was found between lincRNA-p21 levels and SLEDAI-2K scores (Figure 1C, r = 0.706, p = 0.004) or daily proteinuria amounts (Figure 1D, r = 0.686, p = 0.006). No 34203338 TP53COR1 LncRNA Homo sapiens Amyotrophic Lateral Sclerosis SOD1-G93A Murine Model Regulation In Vivo Experiment//qRT-PCR We highlighted a specific area and pathogenetic-stage deregulation in each lncRNA, with linc-p21 being deregulated in all analyzed tissues. No 34356873 TP53-215 LncRNA Homo sapiens Henoch-Schönlein Purpura Nephritis blood Expression[lower expressed] qRT-PCR//RNA-seq The results revealed that the expression of lncRNAs including ENST00000378432, ENST00000571370, uc001kfc.1 and uc010qna.2 was decreased in HSPN patients compared with that in healthy controls. No 30651843 TP29-AS73 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Expression[highly expressed] qRT-PCR TP73?AS1 was significantly upregulated, while miR?34a?5p was downregulated in NSCLC tissues and cells. No 32901838 TOPORS‐AS1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)51) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 TOP1P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TOP1P1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 TONSL-AS1 LncRNA Homo sapiens Coronary Artery Disease patients with CAD Interaction(miR-197/BCL2) qRT-PCR//Transwell Assay//Cell Apoptosis Assay//Western Blot In addition, TONSL-AS1 was downregulated in CAD. We speculated that MAFG-AS1 may sponge miR-145. Moreover, overexpression of TONSL-AS1 increased, while overexpression of miR-197 decreased the expression levels of BCL2. Follow-up study revealed that low expression levels of TONSL-AS1 and high expression levels of miR-197 predicted poor survival of CAD patients. No 33662410 TOM1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TOB1-AS1 LncRNA Homo sapiens Multiple Sclerosis blood Expression[No differently] qRT-PCR The evaluation of target genes expression according to t-test revealed a significant increase of TOB1 (p = 0.0267, 1.6-fold), SKP2 (p = 0.0054, twofold), and TSG (p = 0.0108, 2.4-fold) in patients versus control individuals, although there was no significant difference in TOB1-AS1 expression in participants (p = 0.6725) (Fig. 1). No 31482275 TNKS2-AS1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TNFSF10 LncRNA Homo sapiens Osteoarthritis OA cartilages Regulation[miR-376-3p/FGFR1 axis ] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay It was found that TNFSF10 was upregulated in OA cartilages and stimulated cell proliferation, antiapoptosis, and inflammation for chondrocytes. Altogether, TNFSF10 overexpression probably stimulated proliferation and inflammation, and inhibited apoptosis by regulating the miR-376-3p/FGFR1 axis, implying that its increase contributed to OA progression. No 31297857 TNFSF10 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 TMTC1-202 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[lower expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 TMPRSS11BNL LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TMPRSS11BNL LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 TMPO-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TMPO-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR The findings demonstrated the overexpression of TMPO-AS1 in CRC tissues. Interestingly, the expression level of TMPO-AS1 was significantly correlated with clinicopathological features of the patients such as lymph node and distant metastasis. No 31768869 TMPO-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD samples Interaction(TMPO-AS1/let-7c-5p/STRIP2 network ) Cell Proliferation Assay//qRT-PCR//migration assay Moreover, we confirmed that the TMPO-AS1/let-7c-5p/STRIP2 network regulates STRIP2 overexpression in LUAD and is associated with poor prognosis. Moreover, we confirmed that the TMPO-AS1/let-7c-5p/STRIP2 network regulates STRIP2 overexpression in LUAD and is associated with poor prognosis. No 35774125 TMPO-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues Expression[highly expressed] qRT-PCR We found that TMPO-AS1 was distinctly upregulated in human LSCC tissues compared with corresponding normal specimens (p < 0.01). Higher expressions of TMPO-AS1 were observed to be positively associated with the clinical stage (p = 0.020) and lymph node metastasis (p = 0.027). A clinical study in 187 patients revealed that patients with TMPO-AS1 low expressions had poorer survival than those with TMPO-AS1 high expressions (p = 0.0012). No 32696866 TMEM9B-AS1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1068 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 TMEM98 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 TMEM8B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TMEM74 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TP53COR1 LncRNA Homo sapiens Rectal Neoplasms 70 RC patients treated with preoperative CRT Regulation qRT-PCR The results showed that lincRNA-p21 was upregulated in stage III tumors (p = 0.007) and in tumors with the worst response regarding TRG (p = 0.027) and downstaging (p = 0.016). No 34065723 TP73-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[regulating microRNA-103] CCK8//qRT-PCR//Flow Cytometry//EdU Staining QRT-PCR results indicated that TP73-AS1 expression in HCC samples was conspicuously enhanced compared with paracancerous tissues.Meanwhile, the proliferation ability of cells in the sh-TP73-AS1 group was strikingly lower than that in the control group, while cell apoptosis showed the opposite trend. Besides, qRT-PCR results indicated a negative correlation between microRNA-103 and TP73-AS1 in HCC tissue specimens. The results of the luciferase reporting assay revealed that TP73-AS1 could be targeted by microRNA-103 through binding site. In addition, the cell recovery experiment demonstrated that TP73-AS1 and microRNA-103 might have a mutual regulation, and the two of which could together affect the malignant progression of HCC. QRT-PCR results indicated that TP73-AS1 expression in HCC samples was conspicuously enhanced compared with paracancerous tissues, and patients with a relatively high level of TP73-AS1 had a higher tumor stage and a lower overall survival rate. No 31210297 TTC39C CircRNA Homo sapiens Alzheimer Disease cerebrospinal fluid Expression[lower expressed] qRT-PCR//Microarray By RT-qPCR, circ-LPAR1, circ-AXL and circ-GPHN were increased, whereas circ-PCCA, circ-HAUS4, circ-KIF18B and circ-TTC45C were decreased in AD patients compared with Ctrl subjects, and these circRNAs were disclosed to predict AD risk by receiver operating characteristics curve analysis. No 32315771 TP73-AS1 LncRNA Homo sapiens Medulloblastoma cell lines (UW228.2, MED8A and ONS76) Expression[highly expressed] qRT-PCR We observed a significant upregulation of TP73-AS1 in medulloblastoma compared to normal tissue controls (p < 0.0001). Finally, using the Cavalli cohort, we found that high levels of TP73-AS1 expression are associated with poor patient outcome in the TP53 WT SHH subtypes (β, γ, δ) but not in the TP53 mutant SHH subtype (α; Fig. 1e). Collectively, our analyses suggest that TP73-AS1 is clinically relevant in medulloblastoma, in particular in SHH tumors. No 30777071 TSLD8 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines(SMMC-7721、Huh7、HepG2、Hep3B、L02,HEK293T) Interaction[stabilizing WWOX ] qRT-PCR//Northern Blot//Migration Assay These data suggested that TSLD8 was frequently downregulated in HCC and correlated with poor outcomes.Co-delivery of TSLD8 and WWOX via PuPGEA-based nanocomplexes might provide promising therapeutics for eradicating HCC. No 31230746 TSIX-201 LncRNA Homo sapiens Arthritis, Gouty blood Expression[highly expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 TSEN15 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TRPM2-AS LncRNA Homo sapiens Colorectal Neoplasms CRC samples Epigenetics(methylation) In Vivo Experiment//qRT-PCR Microarray analysis revealed that lncRNAs SNHG6, MIR4435-2HG, and TRPM2-AS1 were upregulated in CRC.These results were validated in colon cell lines. Moreover, qRT-PCR showed that the expression levels of SNHG6 and TRPM2-AS1 were upregulated in the colorectal tumor tissues compared with their paired tissues. Nonetheless, there was no significant increase in MIR4435-2HG expression in CRC samples. Furthermore, we observed a significant hypomethylation of TRPM2-AS1 promoter and its activation in CRC tissues. No 34431156 TRIP12 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 TRIO-212 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TRIM52-204 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 TRIM31 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)102) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 TRIM22-209 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 TRHDE-AS1 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[lower expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 TRHDE-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 TRG-AS1 LncRNA Homo sapiens Glioblastoma glioblastoma tissues,cell lines Interaction[binding with miR-877-5p to regulate SUZ12] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining TRG-AS1 is associated with poor prognosis and is upregulated in glioblastoma tissues and cells. On the other hand, miRNA-877-5p expresses low in glioblastoma and contains binding sites with both TRG-AS1 and SUZ12. Furthermore, TRG-AS1 suppresses the expression of miR-877-5p while miR-877-5p suppresses SUZ12 expression. Overexpression of TRG-AS1 could promote the expression of SUZ12.Rescue assays demonstrates that overexpression of SUZ12 can counteract the decline of glioblastoma cell proliferation induced by knockdown of TRG-AS1. Based on all these assays, TRG-AS1 promotes glioblastoma cell proliferation by acting as a ceRNA of miR-877-5p to regulate SUZ12 expression. TRG-AS1 might serve as a new target in glioblastoma treatment. No 31196742 TRERNA1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissue Expression[highly expressed] qRT-PCR treRNA was found to be highly expressed in colorectal cancer tissue in contrast to adjacent tissue (P<0.05). Moreover, positive correlation was found between high treRNA expression and lymph node metastasis (P<0.05). Patients with high treRNA expression were found with compromised overall survival (OS) compared with the low treRNA expression group, according to Kaplan-Meier analysis. No 31933996 TRERNA1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR In conclusion, TRERNA1 expression was upregulated in CRC tissues. High expression levels of TRERNA1 may be associated with poor OS times, a less favorable prognosis and lymph node metastasis in patients with CRC. TRERNA1 may therefore serve as a useful and novel biomarker for CRC lymph node metastasis and prognosis. No 32391108 TRERNA1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation( HIF-1α ) ISH//IHC TRERNA1 was substantially upregulated in HCC tissues, which was accompanied by aberrant decreased expression of E-cadherin. Moreover, TRERNA1 expression level was positively correlated with the activation of HIF-1α. Importantly, high TRERNA1 expression level can be an independent risk factor for poor prognosis in HCC, especially combining elevated TRERNA1 and HIF-1α with decreased E-cadherin predicted a worst prognosis of patients with HCC. Elevated TRERNA1 level was correlated with high tumor grade, high recurrence rate and poor survival in patients with HCC. No 34560417 TRERNA1 LncRNA Homo sapiens Ependymoma ependymomas tissues Expression[highly expressed] qPCR//IHC Upregulation of gene expression levels of TRERNA1 was seen in intracranial EPNs, with highest expression levels in pediatric posterior fossa EPNs. High TRERNA1 expression was found associated with higher proliferative indices (p = 0.034) and shorter progression free survival (p = 0.002). No 31489574 TRERNA1 LncRNA Homo sapiens Primary Ovarian Insufficiency POF tissues Interaction(miR-23a) qRT-PCR//RNA Pull-Down//Cell Apoptosis Assay Both TRERNA1 and miR-23a were downregulated in POF. In addition, TRERNA1 was detected in both cytoplasm and nuclear samples of granulosa cells, and directly interacted with miR-23a. TRERNA1 did not affect the expression of miR-23a in granulosa cells, while TRERNA1 suppressed the role of miR-23a in enhancing cell apoptosis. No 35034562 TREML5P LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 TRAF3IP2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TRAF3IP2-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).37). No 33330027 TPTEP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TPTEP1 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[lower expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 TPTE2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TPRXL LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TPM3P9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 TPM3-213 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 TPCN1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 TP73-AS1 LncRNA Homo sapiens Stomach Neoplasms blood Mutation[rs3737589 ] qRT-PCR//Genotyping This study was to reveal the association between lncRNAs TP73-AS1 polymorphisms (rs1181865 A > G, rs9800 G > C, rs3737589 A > G, rs2298222 G > A, rs7515164 C > A) and GC in 1000 GC cases and 1000 controls in a Chinese Han population. Rs3737589 G allele had significant associations with the increasing risk of GC (G vs. A: p = .005). Rs3737589 variant genotypes (AG + GG) were related to an increased risk of GC in the elder population (age ≥60), females, nonsmokers, nondrinkers, individuals living in urban, and individuals without family history of GC in stratified analyses. Rs3737589 variant genotypes (AG + GG) were related to the advanced depth of tumor invasion (T3 + T4). Besides, we found that GC patients with AG or GG genotype of rs3737589 had poorer overall survival (OS) than those with AA genotype (p < .05). Rs3737589 variant genotypes (AG + GG) were related to the advanced depth of tumor invasion (T3 + T4). Besides, we found that GC patients with AG or GG genotype of rs3737589 had poorer overall survival (OS) than those with AA genotype (p < .05). No 31549851 TP73-AS1 LncRNA Homo sapiens Colorectal Neoplasms 507 CRC cases and 503 controls Mutation[rs9800 ] qRT-PCR//FISH//Western Blot//Microarray rs9800 polymorphism was significantly related to higher risk in CRC [adjusted odds ratio (AOR) = 1.33, 95% confidence interval (CI) = 1.02-1.75, P = 0.034 in heterozygote codominant model]. There was no difference between TP73-AS1 polymorphisms and different tumor node metastasis (TNM) stages in the adjusted model. Moreover, TP73-AS1 expression level was positively related to different TNM stages. After adjusted for age, gender and TNM, higher TP73-AS1 expression levels were related to shorter recurrence-free survival time [hazard ratio (HR) = 1.66, 95% CI = 1.02-2.71, P = 0.043]. No 34480734 SOD1-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 SOCAR LncRNA Homo sapiens Ovarian Neoplasms Ovarian Cancer tissues Expression[Expression[highly expressed]-expression] CCK8//qRT-PCR//Transwell Assay//Western Blot SOCAR was overexpressed in primary HGSOC tumors compared with normal ovary tissues, and the expression of SOCAR correlated with progression in HGSOC patients. No 31299360 NONHSAT160586.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 PNPLA7 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)112) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 PP7080 LncRNA Homo sapiens Carcinoma, Hepatocellular 40 pairs of HCC and adjacent tissues Interaction(miR-601/SIRT1) qRT-PCR//Colony Formation Assay//Transwell Assay LncRNA PP7080 was highly expressed in HCC and predicted a poor prognosis.Luciferase activity assay identified lncRNA PP7080 as a molecular sponge for miR-601 in HCC cells. LncRNA PP7080 promoted HCC cells proliferation, migration and invasion by miR-601/SIRT1 signal axis. LncRNA PP7080 was highly expressed in HCC and predicted a poor prognosis. No 33955831 PP7080 LncRNA Homo sapiens Colonic Neoplasms COAD tissues Expression[lower expressed] qRT-PCR "To manifest the expression of integrated analysis, we selected the previously obtained eight biomarkers including XXbac‐ B476C20.9, PP7080, CDKN2B‐AS1, LINC00092, CA3‐AS1, HAND2‐AS1, CTD‐2269F5.1, and LINC01082. In Figure 8, these eight selected DElncRNAs for qRT‐PCR confirmation were eight optimal diagnostic lncRNA biomarkers, and these eight DElncRNAs were all downregulated in the high‐ throughput transcriptome datasets for COAD compared with normal controls. The expression of these selected eight genes in qRT‐PCR was consistent with our integrated analysis." No 30269368 PP14571 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 POU6F2-AS2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 POTEH-AS1 LncRNA Mus musculus estrogen-receptor positive breast cancer HER2+ breast cancer tissues Expression(highly expressed) qRT-PCR//Microarray Our results demonstrated that three lncRNA sets, lncRNA-AL390243.1, POTEH-AS1, and lncRNA-AC009975.1, were up-regulated in non-apCR tissues. No 34938660 POT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 POLR3F LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 POLR3B CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 POLR2J4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 POLR2J3-207 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 POLR2E LncRNA Homo sapiens Thyroid Cancer, Papillary Mutation[rs3787016 ] Genotyping Collectively, the POLR2E rs3787016 may be used as a genetic biomarker to predict cancer risk in Chinese population. No 29724531 POLR2E LncRNA Homo sapiens Prostatic Neoplasms blood Mutation[rs3787016 /rs3787016 ] Genotyping Furthermore, rs3787016 CT/rs1046040 CC as well as rs3787016 CT/rs1046040 CT increased the risk of PCa compared to the CC/CC genotype (p = 0.029 and p = 0.014, respectively). Haplotype analysis proposed that rs3787016 T/rs1046040 C significantly increased the risk of PCa compared to C/C (p = 0.037). No 30587086 POLI CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 POLE3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PNN CircRNA Homo sapiens Colorectal Neoplasms Serum Exosomal Expression[highly expressed] qPCR//PCR//Western Blot Validation analysis revealed that the serum exosomal circ-PNN (hsa_circ_0101802) levels were significantly up-regulated in CRC cases compared with those in the healthy control groups. No 32626660 SOBP CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 PMS2P9 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 989 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 PMS2P4 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 568 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 PMS2P2 LncRNA Homo sapiens endometrial adenocarcinoma blood Expression[lower expressed] qRT-PCR We showed that plasma PMS2L2 was downregulated in EA patients compared with healthy controls, and downregulation of PMS2L2 distinguished early-stage EA patients from healthy controls. No 31632150 PMS2P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PMP22 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 PM20D1-AS1 LncRNA Homo sapiens Myasthenia Gravis Expression(highly expressed) qRT-PCR//RNA-seq We identified 378 significantly upregulated and 348 significantly downregulated lncRNAs in MG patients compared with HC. The top 5 lncRNAs (NR_104677.1, ENST00000583253.1, NR_046098.1, NR_022008.1, and ENST00000581362.1) were validated and shown to be significantly increased in the serum exosome of MG, and the expression level of NR_046098.1 significantly increased with the MG grading. No 33543801 PM20D1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PLXNC1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PLVAP LncRNA Homo sapiens Urinary Bladder Neoplasms bladder tissues Expression[lower expressed] qRT-PCR PV1 was down-regulated in tumor tissues compared with both ANCTs and normal controls (Expression ratios of 0.48 and 0.14; P values of 0.4 and <0.001 respectively). No 31054930 PLUT LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 PLEKHM1P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PLEKHA8P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PLCD1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 Plat LncRNA Mus musculus Breast Neoplasms lung tissue of nude mice Regulation(TGF-β) qRT-PCR//RNA Pull-Down Overexpression of lncRNA TPA decreased the expression of E-cadherin, and significantly increased the expression of Vimentin, fibronectin and TGF-β1 (p < 0.01), and increased the migration rate, migration ability and invasion ability of cell group (P < 0.01). No 34422811 PPIA-206 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[lower expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 PPIAP19 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1057 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 PPIB-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PPIG-209 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PRPF40A CircRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR//circRNA-seq The top 5 up- and downregulated circRNAs in patients with are listed in Table IV. No 32765789 PRO2852 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 528 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 PRO1804 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PRO1804 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1050 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 PRNCR1 LncRNA Homo sapiens Stomach Neoplasms blood Mutation[rs13252298 ] Genotyping In the stratification analyses, the recessive model indicated that the rs1016343 TT genotype was significantly associated with decreased GC risk in individuals aged <60 years showing lymph node metastasis (LNM)-negative results. The rs13252298 GG genotype in the recessive model showed increased GC risk in subjects aged ≥60 years showing LNM-positive results and those aged ≥60 years in tumor stage III. In the dominant model, the rs16901946 combined genotype (AG/GG) was significantly associated with increased GC risk in subjects aged <60 years with tumor stage III. In the recessive model, the rs16901946 GG genotype was associated with decreased risk of GC and IGC in males aged ≥60 years. Thus, genetic variations in PRNCR1 may contribute to susceptibility to GC. No 31288430 PRNCR1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] qRT-PCR Our results revealed a significant downregulation of AOC4P, however, upregulated PRNCR1 and PCAT1 were found in tumor tissues compared to NATs and clinically healthy normal tissues (P < 0.06). No 32853955 PRNCR1 LncRNA Homo sapiens Lung Neoplasms 438 patients with lung cancer and 456 healthy controls in the Han population from southern China Mutation(rs1456315 ) Genotyping The rs1456315 T allele increased the risk of lung cancer [OR=1.95, 95% CI (1.58-2.43), P=0.003] compared to the rs1456315 C allele, and rs1456315 significantly increased the risk of lung cancer in the dominant model [OR=1.86, 95% CI (1.16-3.00), P=0.002]. No 33542645 PRNCR1 LncRNA Homo sapiens Colorectal Neoplasms blood Mutation[rs1456315 ] Genotyping The genotyping analysis for SNP rs1456315 showed increased association with colorectal cancer with the homozygous CC variant allele (OR: 2.09; χ2 = 4.95; CI: 1.08-4.02; p = 0.02), the minor allele frequency, and additive genotype, respectively (OR: 1.55; χ2 = 6.24; CI: 1.09-2.19; p = 0.01) & (OR: 1.64; χ2 = 4.04; CI: 1.01-2.67; p = 0.04). A risk association was also observed among younger age patients (≤57) and in female patients as well as in patients with tumors of the colon. No 31487296 PRNCR1 LncRNA Homo sapiens Sars-Cov-2 Vaccination Breakthrough Infections 57 VBT and unvaccinated COVID-19 patients Expression(highly expressed) RNA-seq//Bioinformatics Analysis Further, out of the 12 lncRNA genes, 7 lncRNAs are reported to modulate immune/inflammatory responses in infectious diseases. Out of the 7 lncRNAs, LUCAT1, MALAT1, NEAT1 and GAS5 were downregulated in the VBT. LUCAT1 is a negative regulator of interferon response, and downregulation of LUCAT1 suggests an activated interferon response (30). MALAT1 is known to negatively regulate the immune response and positively regulate the inflammatory response in the infected individuals, therefore downregulation of MALAT1 in the breakthrough infection suggests an upregulated immune response and downregulated inflammatory response (31, 32). NEAT1 and GAS5 also act as pro-inflammatory lncRNAs, and their downregulation is an indicator of decreased inflammatory response in the VBT (33, 34). Amongst the upregulated lncRNAs, ROR1-AS1, UGDH-AS1 and LINC00273 were upregulated in the VBT. The upregulation of ROR1-AS1 and LINC00273 indicates a heightened immune response, whereas upregulation of UGDH-AS1 suggests a decreased disease severity possibly modulated by MOV10 and EDN1 (8). No 36466827 PRMT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PRKY LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PRKCA-AS1 LncRNA Homo sapiens Rheumatic Heart Disease mitral valve tissues from three mitral stenosis patients with RHD Regulation In Vivo Experiment//Western Blot//qRT-PCR//RNA-seq//Luciferase Report Assay//Bioinformatics Analysis The presence of hypomethylated CpG islands at promoter and 5' terminal of PRKCA was observed in RHD accompanied with highly expressed PRKCA and down-regulated antisense long non-coding RNA (lncRNA) PRKCA-AS1 compared to health control. Additionally, PRKCA-AS1 was further determined to bind with promoter of PRKCA via 5' terminal and interact with DNMT1 via 3' terminal. No 34695392 PRKCA-AS1 LncRNA Homo sapiens Rheumatic Heart Disease three mitral stenosis patients with RHD Expression(highly expressed) FISH//ELISA//qPCR//Western Blot The presence of hypomethylated CpG islands at promoter and 5' terminal of PRKCA was observed in RHD accompanied with highly expressed PRKCA and down-regulated antisense long non-coding RNA (lncRNA) PRKCA-AS1 compared to health control. Furthermore, the enrichments of DNMT1/3A/3B on PRKCA were detected by ChIP-qPCR assay in vivo and in human cardiomyocyte AC16 and RL-14 cells exposed to TNF-α in vitro, and both demonstrated that DNMT1 substantially contributed to DNA methylation. No 34482802 PRKAR1B-AS2-201 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[highly expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 3. No 31619123 PRKAG2-222 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 PRKAB2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PRH1-PRR4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PRH1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PRECSIT LncRNA Homo sapiens COVID-19 peripheral blood Regulation qRT-PCR Expression of SNHG6 was considerably lower in COVID-19 patients compared with control subjects (Ratio of mean expression (RME) = 0.22, P value = 7.04E-05) and in both female and male COVID-19 patients compared with sex-matched unaffected individuals (RME = 0.32, P value = 0.04 and RME = 0.16, P value = 0.000679683, respectively). However, its expression was similar among ICU-hospitalized and non-ICU patients. Similarly, expression of SNHG16 was lower in in COVID-19 patients compared with controls (RME = 0.20, P value = 5.94E-05) and in both female and male patients compared with sex-matched controls (RME = 0.32, P value = 0.04 and RME = 0.14, P value = 0.000496435, respectively) with no significant difference among ICU-hospitalized and non-ICU hospitalized patients. Expression of VDR was lower in COVID-19 patients compared with controls (RME = 0.42, P value = 0.04) and in male patients compared with male controls (RME = 0.27, P value = 0.02). Yet, expression of VDR was statistically similar between female subgroups and between ICU-hospitalized and non-ICU hospitalized patients. Expression levels CYP27B, Linc00511 and Linc00346 were similar among COVID-19 patients and healthy subjects or between their subgroups. Significant correlations have been detected between expression levels of VDR, CYP27B and SNHG6, SNHG16, Linc00511 and Linc00346 lncRNAs both among COVID-19 patients and among healthy controls with the most significant ones being SNHG6 and SNHG16 (r = 0.74, P value = 3.26e-17 and r = 0.81, P = 1.54e-22, respectively). No 34147082 PRDM5 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 PRC1-AS1 LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 PPT2-EGFL8 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PPP4R1-AS1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 PPP2R3C LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PPP26R1-AS0 LncRNA Homo sapiens Neuroblastoma Neuroblastoma tissues Expression[Expression[highly expressed]-expression] ChIP-seq//RNA-seq Differential analysis revealed nine significantly differentially expressed (more than 2-fold change with corrected p-value) lncRNAs between tumor cells and matched MNCs. Of these, RFPL1S (p = 0.0001), PPP1R26-AS1 (p = 0.03), RP11-439E19.3 (p = 1.24 × 10–6), CASC15 (p = 1.6 × 10–7), AC004540.5 (p = 0.0002), and CTD-2881E23.2 (p = 1.6 × 10–9) were found to be significantly Expression[up-expression]regulated (Figure 1B), while USP3-AS1 (p = 1.78 × 10–6), CHRM3-AS2 (p = 0.003) and RP6-99M1.2 (p = 0.002) were significantly downregulated (Figure 1C). No 31920530 PPP1R8P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 885 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 PPP1R3B-DT LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Expression(highly expressed) Cell Proliferation Assay//qRT-PCR//migration assay In this study, we investigated the role of AC02278.4 in LUAD and found that AC02278.4 expression was significantly increased in datasets extracted from The Cancer Genome Atlas. Increased expression of lncRNA-AC02278.4 was correlated with advanced clinical parameters.Our clinical sample results also confirmed that AC02278.4 was highly expressed in LUAD and correlated with adverse clinical outcomes. No 35463380 PPP1CA-206 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PPIHP1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)100) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 PLAC9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PLA1A LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PKM-214 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PCSEAT LncRNA Homo sapiens Prostatic Neoplasms Prostate Cancer tissues Expression[highly expressed] Western Blot//qRT-PCR//Luciferase Report Assay//migration assay//Cell Proliferation Assay//ChIP-seq//ChIP In more than 20 types of tissues, PRCAT38 was solely expressed in both normal and tumor prostate samples (Supplementary Figure S1A). Importantly, it was significantly up-regulated in cancer when compared to normal prostate tissue (Supplementary Figure S1B). No 31405024 PCNA-AS1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 PCMTD1-205 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PCM1-202 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PCLAF LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PCLAF LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 PCGEM1 LncRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR The expression level of PCGEM1 in the GC group was significantly higher than that in the healthy control subjects. In addition, the PCGEM1 expression level was associated with tumor differentiation and TNM stage. No 31421977 PCF11-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PCED1B-AS1 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[highly expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 PCED1B-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck TCGA Regulation qRT-PCR Then, we recognized a set of six FElncRNAs PFLS (SLCO4A1-AS1, C1RL-AS1, PCED1B-AS1, HOXB-AS3, MIR9-3HG, and SFTA1P) for predicting patients' prognostic risks and survival outcomes. Notably, the low-risk group of the PFLS showed a higher MHC score and cytolytic activity (CYT) score than the high-risk group, implying the low-risk group may have greater tumor surveillance and killing ability.  No 34976018 PCDHB5 LncRNA Homo sapiens Retinoblastoma 23 tumor tissues and 5 adjacent retinal tissue Interaction(miR-495-3p) qPCR PCR analysis using 23 tumor tissues and 5 adjacent retinal tissue showed increased expression of PCDHB5 in tumor samples, and supported the predicted upregulation of mitotic checkpoint serine/threonine kinase (BUB1) by MALAT1 via miR-495-3p. No 34419445 PCDHB18P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PCCA CircRNA Homo sapiens Alzheimer Disease cerebrospinal fluid Expression[lower expressed] qRT-PCR//Microarray By RT-qPCR, circ-LPAR1, circ-AXL and circ-GPHN were increased, whereas circ-PCCA, circ-HAUS4, circ-KIF18B and circ-TTC42C were decreased in AD patients compared with Ctrl subjects, and these circRNAs were disclosed to predict AD risk by receiver operating characteristics curve analysis. No 32315771 PCBP3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PCBP1-AS1-240 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 PCBP1-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[lower expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 PCBP1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,plasma regulation[PCBP1/PRL-3/AKT Pathway] qRT-PCR//RIP Here we show that PCBP1-AS1, identified by microarray analysis on pre- and post-operative HCC plasma specimens, was highly expressed in human HCC, clinically verified as a prometastatic factor and markedly associated with poor prognosis in patients with hepatocellular carcinoma. The upregulation of PCBP1-AS1 enhances proliferation and metastasis in HCC, thus regulating the PCBP1-PRL-3-AKT signalling pathway. Here we show that PCBP1-AS1, identified by microarray analysis on pre- and post-operative HCC plasma specimens, was highly expressed in human HCC, clinically verified as a prometastatic factor and markedly associated with poor prognosis in patients with hepatocellular carcinoma. No 32753957 PCAT7 LncRNA Homo sapiens Breast Neoplasms breast cancer tissue and cells Interaction(ErbB/PI3K/Akt) qRT-PCR//Western Blot PCAT7 was found to be highly expressed in breast cancer tissue and cells, which activated the ErbB/PI3K/Akt pathway to potentiate cancer cell proliferation, migration and invasion and suppress apoptosis. No 33401925 PCAT7 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PCAT7 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells Expression[highly expressed] qRT-PCR The abundance of lncRNA PCAT6 was enhanced in CC tissues and cells compared with that in corresponding normal tissues and normal cervical epithelial cells Ect1/E6E7. No 32103984 PCAT6 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues and cells Expression[highly expressed] CCK8//qRT-PCR//Colony Formation Assay//Flow Cytometry PCAT6 and TPD52 were highly expressed and miR-185-5p was lowly expressed in TNBC tissues and cells, which was associated with an aggressive tumor phenotype in patients, affecting lymph node metastasis and clinical stage. PCAT6 and TPD52 were highly expressed and miR-185-5p was lowly expressed in TNBC tissues and cells, which was associated with an aggressive tumor phenotype in patients, affecting lymph node metastasis and clinical stage. No 32308433 PCAT6 LncRNA Homo sapiens Glioblastoma glioblastoma tissues and cell lines regulation[miR-513/IGF2BP1] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//ChIP We observed that PCAT6 expression was upregulated in glioblastoma tissues and cell lines and its high expression was due to the transcriptional activation by Yin Yang 1. In conclusion, our results indicate that PCAT6/miR-513/IGF2BP1 positive feedback loop plays a crucial role in facilitating glioblastoma progression. No 32990800 PCAT6 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR//Microarray The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated). No 32020063 PCAT29 LncRNA Homo sapiens Depressive Disorder, Major blood Expression[highly expressed] qRT-PCR Five were found to be differentially expressed in MDD patients compared to healthy subjects (Fig. 1, Supplemenatal Table 3): MER11C, PCAT1, PCAT29, RMRP, and Y5. Whereas the expression level of RMRP in MDD patients was significantly lower than in healthy subjects (p = 0.000227, U = 175), the expression levels of MER11C, PCAT1, PCAT29, and Y5 were significantly higher in MDD patients than in healthy subjects (MER11C: p = 0.0215, U = 262; PCAT1: p = 0.0183, U = 199; PCAT29: p = 0.00693, U = 165; Y5: p = 0.00665, U = 226). No 31351391 PCAT19 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PCAT19 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[lower expressed] qRT-PCR//Microarray The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated). No 32020063 PCAT18 LncRNA Homo sapiens Stomach Neoplasms regulation[miR-135b/CLDN11] qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay PCAT18 down-expression promoted proliferation, migration and invasion of gastric cancer cells.Over-expressed lncRNA PCAT18 inhibits proliferation, migration and invasion of gastric cancer cells through regulation of miR-135b/CLDN11. No 32119960 PCAT14 LncRNA Homo sapiens Prostatic Neoplasms TCGA(499 prostate cancer samples and 52 adjacent normal tissue samples) Expression [highly expressed] RNA-seq The ROC curve showed that PCAT14 had a significant diagnostic ability (area under curve = 0.818) for prostate cancer. A reduced expression of PCAT14 in prostate cancer was related to T stage, N stage, primary therapy outcome, residual tumor, Gleason score, and age. The expression of PCAT14 was independently associated with the progression-free interval in prostate cancer patients. A reduced expression of PCAT14 in prostate cancer was related to T stage, N stage, primary therapy outcome, residual tumor, Gleason score, and age. No 35003397 PCAT1-228 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 PCAT1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] qRT-PCR Our results revealed a significant downregulation of AOC4P, however, upregulated PRNCR1 and PCAT1 were found in tumor tissues compared to NATs and clinically healthy normal tissues (P < 0.07). No 32853955 PCNX2 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 PCSK2-2 LncRNA Homo sapiens Stomach Neoplasms blood Expression[lower expressed] qRT-PCR Transmission electron microscopy, nanoparticle size analysis, and Western blotting showed successful separation of serum exosomes. qRT-PCR results revealed that compared with the healthy control, Lnc RNA PCSK2-2:1 expression level in serum exosomes of gastric cancer patients was significantly downregulated (p=0.006). Moreover, the expression level of Exo-Lnc RNA PCSK2-2:1 was correlated with tumor size (p=0.0441), tumor stage (p=0.0061), and venous invasion (p=0.0367). The area under the curve of Exo-Lnc RNA PCSK2-2:1 was 0.896. At the optimal cut-off value, the diagnostic sensitivity and specificity were 84% and 86.5%, respectively. No 31819499 PKM-212 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PCSK5 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 PKM-211 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PITX1-AS1 LncRNA Homo sapiens Colorectal Neoplasms 512 cases and 513 controls Mutation(rs4976270, rs4976270) Genotyping Our results showed that C5orf66 SNPs rs4976270 (odds ratio [OR] = 1.69, p = 0.021) and rs639933 (OR = 1.67, p = 0.024) were, respectively, associated with increasing CRC risk in the southern Chinese Han population. No 34818221 PISRT1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)17) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 PINK1-AS LncRNA Homo sapiens Multiple Sclerosis blood Expression[highly expressed] qRT-PCR Peripheral expression of PINK1-AS was remarkably higher in MS patients compared with healthy individuals. No 33161812 PIK3R2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PIGT LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PICSAR LncRNA Homo sapiens Skin Neoplasms serum and tumor tissues Expression(highly expressed) qRT-PCR The expression of PICSAR was upregulated in serum of cSCC patients and tumor tissues of patients.PICSAR expression was correlated with tumor size, grade of differentiation and TNM stages, and significantly increased in cSCC patients with poor tumor differentiation and cSCC patients with III-IV TNM stage. Additionally, serum PICSAR expression had relatively high diagnostic accuracy for the screening of cSCC. patients with high PICSAR expression had lower overall survival than the patients with low PICSAR expression, and PICSAR expression was an independent prognostic factors for cSCC patients. No 34043139 PHTF1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PGS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PGM5-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PGM5-AS1 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues and cells interaction[sponging miR-100-5p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We found that both PGM5-AS1 and SMAD4 were downregulated in human colorectal cancer tissues and cells.In this study, we found that lncRNA-PGM5-AS1 was low expressed in human colorectal cancer cells, which could promote tumor proliferation, migration and invasion by serving as a molecular sponge and by modulating the inhibitory effect of miR-100-5p on tumor suppressor gene SMAD4. No 32767323 PGM5-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC patient plasma Expression(lower expressed) qRT-PCR lncRNA urothelial carcinoma-associated 1 (UCA1) and lncRNA phosphoglucomutase 5-antisense RNA 1 (PGM5-AS1) were the most significantly up- and down-regulated lncRNAs in CRC patient plasma, respectively. The area under the ROC curve was calculated to be 0.766, 0.754 and 0.798 for UCA1, PGM5-AS1 and the combination of these two lncRNAs, respectively. Moreover, the diagnostic potential of these two lncRNAs was even higher for the early stages of CRC. The combination of UCA1 and PGM5-AS1 enhanced the AUC to 0.832, and when the lncRNAs were used with carcinoembryonic antigen (CEA), the AUC was further improved to 0.874. No 34212174 PGM5-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Expression[lower expressed] qRT-PCR The expressions of PGM5-AS1 in cancer specimens were lower than those in matched non-tumor specimens from the ccRCC patient (p<0.05). Downregulation of PGM5-AS1 was closely associated with more advanced clinical features, including lymph nodes metastasis (p=0.007) and distant metastasis (p=0.037). A clinical study revealed that ccRCC patients with lower PGM5-AS1 expressions had substantially shorter overall survival (OS) and disease-free survival (DFS) than patients with higher PGM5-AS1 expressions. No 31858536 PGAP2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PFAR LncRNA Homo sapiens Idiopathic Pulmonary Fibrosis cell lines Interaction[binding to miR-15a ] Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//EdU Staining In conclusion, our results revealed that PFAR functions as a competitive endogenous RNA (ceRNA) by acting as a sponge for miR-15a, revealing a potential regulatory network involving PFAR and miR-15a with a role in the modulation of YAP1-Twist expression. No 31273058 PELP1 LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-13A) Expression[highly expressed] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD7 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 Peg10 LncRNA Mus musculus Cardiomegaly Heart tissue Interaction[regulating HOXA9] qRT-PCR//Western Blot//IF Compared with mice in sham group, those in TAC group presented higher levels of PEG10, ANP and BNP.PE treatment markedly upregulated PEG10, ANP and BNP in primary cardiomyocytes, which were downregulated by transfection of si-PEG10. Besides, surface area of cardiomyocytes was enlarged by PE treatment, which was reduced after silence of PEG10. Silence of HOXA9 presented a similar effect as that of PEG10 in cardiomyocytes. Transfection of si-HOXA9 reversed the expanded cell surface area, and upregulated ANP and BNP in cardiomyocytes overexpressing PEG10. No 31389601 PEDS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PDZRN3-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PDXK-204 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 PDXDC2P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PDPK2P LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Interaction[PDK1/AKT/Caspase 3 pathway] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//Flow Cytometry//Transwell Assay lncRNA-PDPK2P was highly expressed in HCC tissues with a distinct positive correlation between PDPK2P and PDK1, and the upregulation was clinically associated with a larger tumor embolus, low differentiation, and poor survival.Mechanistically, lncRNA-PDPK2P interacted with PDK1 and promoted HCC progression through the PDK1/AKT/caspase 3 signaling pathway. lncRNA-PDPK2P was highly expressed in HCC tissues with a distinct positive correlation between PDPK2P and PDK1, and the upregulation was clinically associated with a larger tumor embolus, low differentiation, and poor survival. No 31368655 PDIA3P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PDCL3P4 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 689 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 PDCD4-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PDCD4-206 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PDCD11 CircRNA Homo sapiens lung giant cell carcinoma LLCC patients Expression(highly expressed) qRT-PCR Plasma circ-PDCD11 was specifically upregulated in LLCC but not in other lung cancer types, compared to the controls. High plasma circ-PDCD11 levels were closely correlated with poor survival of LLCC patients. No 36017647 PCTP-208 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 PRPF40A-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PRR5-212 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 PRR7-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC samples Expression(highly expressed) qRT-PCR We found that PRR7-AS1 expressions were distinctly overexpressed in HCC samples compared with nontumor samples. Finally, we found that PRR7-AS1 expression was associated with the expression of NK CD56bright cells, Th2 cells, TFH, macrophages, Th1 cells, aDC, T helper cells, cytotoxic cells, DC, Tgd, neutrophils, and Th17 cells. ROC assays revealed that PRR7-AS1 effectively differentiated HCC specimens from normal tissues with an AUC of 0.875 (95% CI: 0.840 to 0.911). Moreover, the high PRR7-AS1 expression was associated with advanced clinical stage and poor prognosis of HCC patients. No 36059812 RAMS11 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression(highly expressed) qRT-PCR lncRNA (LINC01564, RAMS11), CBX4, and TOP2A relative expression levels were upregulated in both patient groups compared to controls (p < 0.001*), with the highest levels in the HCC group compared with the CHC group. Additionally, these levels were significantly positively correlated with the clinicopathological features of HCC. No 36672564 RALA-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 RAET1K LncRNA Homo sapiens Adenocarcinoma of Lung Expression[lower expressed] qRT-PCR "The results showed that CEBPA‐AS1 and GVINP1 were downregulated in LUAD tumor tissues, while MIR31HG and RAET1K were upregulated in LUAD tumor tissues (Figure 4). The qRT‐PCR results of these four lncRNAs were consistent with our TCGA bioinformatics results, indicating that our TCGA analysis was credible" No 30125988 RAET1G LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RAD51L3-RFFL LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RAD51C LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-17A) Expression[highly expressed] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD11 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 RAD51C LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RAD51B LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-11A) Expression[highly expressed] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD5 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 RAD51-AS1 LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 RAD51 LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-25A) Expression[lower expressed] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD19 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 RAD23A LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RACK1-216 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RACK1-202 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RABL3-209 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 RABGGTB-212 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 RAB4A-AS1-201 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR The expression of lncRNA ENST00000429227.1 in HCC tissues was higher than that in adjacent normal tissues (p<0.05) The expression of lncRNA ENST00000429227.1 in HCC tissues was higher than that in adjacent normal tissues (p<0.05), which was correlated with pathological parameters such as surgical margin (p=0.042), AFP (p=0.022) and Barcelona Clinic Liver Cancer (BCLC) stage (p=0.008). Survival analysis showed that high expression of lncRNA ENST00000429227.1 was associated with a decrease in overall survival (OS) rate of HCC patients. No 31472071 RAB24 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RAB23 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 RAB11B-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RAB11B-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 QARS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PYCR3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PXN-AS1-L LncRNA Homo sapiens Glioma glioma tissue Expression[highly expressed] qRT-PCR PXN-AS1-L levels were differentially upregulated in glioma specimens compared with paired non-tumor specimens. Higher levels of PXN-AS1-L in glioma were observed to be positively associated with WHO grade (p = 0.019), KPS (p = 0.008)and tumor recurrence (p = 0.019). Survival assays revealed that glioma patients with higher PXN-AS1-L expressions had worse overall survival rates. In multivariate analysis, upregulation of PXN-AS1-L expressions (Risk ratio = 2.663, 1.218-4.532, p = 0.014) in glioma tissues was confirmed to be an independent prognostic factor of overall survival in patients. No 31696482 PWARSN LncRNA Homo sapiens Diabetic Nephropathies proximal tubular epithelial cell Regulation(TXNIP ) In Vivo Experiment//qRT-PCR//RIP//FISH//Luciferase Report Assay Then we explored that PWARSN enhanced TXNIP-driven PTECs pyroptosis in vitro and in vivo. Mechanistically, cytoplasmic PWARSN sponged miR-372-3p to promote TXNIP expression. Moreover, nuclear PWARSN interacted and facilitated RNA binding motif protein X-linked (RBMX) degradation through ubiquitination, resulting in the initiation of TXNIP transcription by reducing H3K9me3-enrichment at the TXNIP promoter. Further analysis indicated that PWARSN might be a potential biomarker for DKD. No 36316968 PWAR5 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PWAR5 LncRNA Homo sapiens Myasthenia Gravis Expression(highly expressed) qRT-PCR//RNA-seq We identified 378 significantly upregulated and 348 significantly downregulated lncRNAs in MG patients compared with HC. The top 5 lncRNAs (NR_104677.1, ENST00000583253.1, NR_046098.1, NR_022008.1, and ENST00000581362.1) were validated and shown to be significantly increased in the serum exosome of MG, and the expression level of NR_046098.1 significantly increased with the MG grading. No 33543801 PVT1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Interaction[miR-125] qRT-PCR//Luciferase Report Assay Compared with paracancerous tissues, the expression of PVT1 and miR-125 was significantly increased in gastric cancer tissues.PVT1 specifically bound to the 3'UTR of miR-125, whereas the inhibition of PVT1 inhibited the ability of proliferation and invasion of gastric cancer cells. In vitro experiment of tumor formation in nude mice showed that the tumor volume and weight of the tumor-bearing mice in the si-PVT1 groExpression[up-expression] were significantly reduced. PVT1 plays an important role in the occurrence and development of gastric cancer, it can regulate the proliferation and invasion of gastric cancer cells by targeting miR-125 activity. The higher the gastric cancer staging was, the more obvious the expression level of PVT1 in the tissues of patients with gastric cancer was, and the more obvious the expression of PVT1 in the tissues of patients with gastric lymph node metastasis was. No 31966056 PVT1 LncRNA Homo sapiens Stomach Neoplasms GC tissue Expression[highly expressed] CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay Meanwhile, the level of HOTAIR, H19, PVT1, and LINC00152 was upregulated. No 32951010 PVT1 LncRNA Homo sapiens Stomach Neoplasms 102 pairs of tumorous and adjacent non-tumorous gastric biopsy samples of GC cases Expression [highly expressed] qRT-PCR The PVT1 and ZFAS1 expressions showed a significant increase and decrease in GC samples as compared with non-cancerous tissues, respectively. PVT1 expression was significantly associated with and lymph-node involvement (p = 0.0007). Moreover, ZFAS1 expression demonstrated a significant association with lymph-node involvement (p = 0.0005), and tumor size >5 cm (p = 0.003). No 34546507 PVT1 LncRNA Homo sapiens Stomach Neoplasms GC samples Interaction(hsa-miR-30a-3p) RNA-seq DEGs were Myc, YY1, and PVT1 and PVT1 was significantly different (adj. P=1.11E-11). The correlation coefficient between PVT1 and Myc was 0.42. A ceRNA network model suggested the hsa-miR-30a-3p was interacted between PVT1 and Myc, playing the role of information transmission. PVT1 expression was upregulated in human gastric cancer tissues and its relative PVT1 expression of PT was increased two fold compared to GCT. The expressions of PVT1 from the tumor tissues were significantly upregulated in GCT. Survival analysis of these genes suggested that lncRNA PVT1 might influence the GC case survival (p=0.06). No 35414508 RAMP2-AS1 LncRNA Homo sapiens Chondrosarcoma serum regulation[miR-2355-5p/VEGFR2 Axis] qRT-PCR//Transwell Assay LncRNA microarray analysis revealed that exosomes carried lncRNA RAMP2-AS1, and further verification showed that the level of RAMP2-AS1 was increased in the serum of chondrosarcoma patients and was closely related to local invasiveness, distant metastasis and poor prognosis. Moreover, dual luciferase reporter assay and rescue experiments suggested that the RAMP2-AS1/miR-2355-5p/VEGFR2 axis was responsible for exosome-induced angiogenesis of HUVECs. LncRNA microarray analysis revealed that exosomes carried lncRNA RAMP2-AS1, and further verification showed that the level of RAMP2-AS1 was increased in the serum of chondrosarcoma patients and was closely related to local invasiveness, distant metastasis and poor prognosis. No 32368088 RAPGEF2-212 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PVT1 LncRNA Homo sapiens Colorectal Neoplasms cancer tissues Expression[highly expressed] qRT-PCR Our results revealed that PVT1 expression in cancer tissues of colorectal cancer was significantly higher than that of adjacent tissues (P<0.001). High PVT1 expression was increased by 51.4% (108/210), which was significantly correlated with the tumor differentiation, the depth of invasion, the stage of tumor, node, metastasis (TNM), and lymphatic metastasis. The Kaplan-Meier analysis showed that high PVT1 expression resulted in a shorter disease-free survival (Log-rank test P<0.001) and overall survival (Log-rank test P<0.001) compared with the low PVT1 expression group in colorectal cancer patients, whether at TNM I/II stage or at TNM III/IV stage. No 29888675 RAPGEF5-208 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 RGS5-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 RFPL3S LncRNA Homo sapiens Lung Neoplasms lung cancer tissues Expression[highly expressed] qRT-PCR//IHC It was revealed that RFPL3S was highly expressed in lung cancer tissues when compared with normal tissues and was significantly associated with pN factor, pTNM stage and Ki-67 labeling index. In the survival analyses, increased RFPL3S expression was associated with poor survival and was inversely associated with first progression in all patients. No 32724368 RFPL0S LncRNA Homo sapiens Neuroblastoma Neuroblastoma tissues Expression[Expression[highly expressed]-expression] ChIP-seq//RNA-seq Differential analysis revealed nine significantly differentially expressed (more than 2-fold change with corrected p-value) lncRNAs between tumor cells and matched MNCs. Of these, RFPL1S (p = 0.0001), PPP1R26-AS1 (p = 0.03), RP11-439E19.3 (p = 1.24 × 10–6), CASC15 (p = 1.6 × 10–7), AC004540.5 (p = 0.0002), and CTD-2881E23.2 (p = 1.6 × 10–9) were found to be significantly Expression[up-expression]regulated (Figure 1B), while USP3-AS1 (p = 1.78 × 10–6), CHRM3-AS2 (p = 0.003) and RP6-99M1.2 (p = 0.002) were significantly downregulated (Figure 1C). No 31920530 RFFL LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 REXO11L83P LncRNA Homo sapiens Arthritis, Rheumatoid keen synovial tissues Expression[lower expressed] qRT-PCR Results of RT-qPCR showed that the levels of lncRNAs MTCO2P12, KCNQ5-IT1 and RP11-83J16.1 were increased, whereas lncRNAs LINC00570, RP11-342M1.6, and REXO1L9P were decreased in RA patients compared to controls. No 32355550 RERT LncRNA Homo sapiens Lung Neoplasms Lung tissues Mutation[rs10680577] qRT-PCR//Genotyping Quantitative real-time PCR was used to measure RERT-lncRNA and EGLN2 expressions. Subjects with Del allele of rs10680577 exhibited an elevated risk of lung cancer. The expressions of RERT-lncRNA and EGLN2 in tumor tissues were higher than adjacent normal tissues, manifesting a positive correlation. Compared to patients with Ins/Ins genotype carriers, those with Ins/Del + Del/Del genotype carriers had upregulated expressions of RERT-lncRNA and EGLN2. Moreover, Ins/Del + Del/Del genotype and expressions of RERT-lncRNA and EGLN2 were associated with age, smoking habits, and TNM stage in lung cancer patients. Besides, patients with Ins/Ins genotype of rs10680577 had a longer OS than those with Ins/Del + Del/Del genotype carriers, and patients with lower expressions of RERT-lncRNA and EGLN2 presented a shorter OS than those with higher expressions. COX multivariate analysis demonstrated that Ins/Del + Del/Del genotype and higher expressions of RERT lncRNA and EGLN2 were risk factors affecting the prognosis of lung cancer. The Ins/Del polymorphism (rs10680577) in RERT-lncRNA was correlated with the risk, major clinicopathological features, and prognosis of lung cancer patients, and the patients with Ins/Del + Del/Del genotype carriers had higher expressions of RERT-lncRNA and EGLN2 than those with Ins/Ins carriers. No 30073577 REPS2 CircRNA Homo sapiens Stomach Neoplasms blood Expression[lower expressed] qRT-PCR//circRNA-seq The top 5 up- and downregulated circRNAs in patients with are listed in Table IV. No 32765789 RELCH LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RDH11 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 RCN1P2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 680 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RBPJ-230 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 RBP7 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RBMXP3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 706 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RBM5-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RBM5 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RBM43P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 754 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RBM34 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RBM12B-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RBM11-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 RBL2-202 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 RBBP4P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1065 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RBAT1 LncRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues interaction[HNRNPL ] qRT-PCR Here, we found that RBAT1 expression was significantly higher in Rb and BCa tissues than that in adjacent tissues. RBAT1 overexpression upregulates a known oncogene, E2F4, via directly recruiting HNPNPL to its promoter and cis-activating its expression. No 32669100 RBAT1 LncRNA Homo sapiens ovarian carcinoma OC plasma and tissues Expression(highly expressed) qRT-PCR RBAT1 was overexpressed in both OC plasma and tissues. Plasma RBAT1 levels were correlated with RBAT1 levels in OC tissues but not in non-tumor tissues. Patients with high plasma RBAT1 levels had a shorter survival. No 36206099 RBAT1 LncRNA Homo sapiens Retinoblastoma Rb tissues interaction[HNRNPL ] qRT-PCR Here, we found that RBAT1 expression was significantly higher in Rb and BCa tissues than that in adjacent tissues. RBAT1 overexpression upregulates a known oncogene, E2F3, via directly recruiting HNPNPL to its promoter and cis-activating its expression. No 32669100 RB1 LncRNA Homo sapiens Colorectal Neoplasms 50 paired colorectal tumors and non-tumor marginal tissues, 30 paired adenomatous colorectal polyps (ACPs) and matched adjacent normal tissues Expression(highly expressed) Bioinformatics Analysis Despite the downregulation of FER1L4 and upregulation of RB1 in tumors compared with non-tumor tissues, the expression of RB1 was positively correlated with the expression of FER1L4 in the colorectal tumor as well as in the polyp tissues. FER1L4 expression level might be considered as a potential biomarker for colorectal cancer development. No 34132945 RASGEF1A CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 RASAL2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RASA4CP LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RARB-207 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 PVT1 LncRNA Homo sapiens Breast Neoplasms serum Expression(highly expressed) qRT-PCR//ELISA The serum levels of HOTAIR, PAI-1, and OPN were significantly higher in breast cancer patients compared to controls and fibroadenoma patients. The serum level of PVT1 was significantly higher in breast cancer patients than in the controls, while that of NEAT1 was significantly lower in breast cancer patients compared to controls and fibroadenoma patients. No 33670447 PVT1 LncRNA Homo sapiens Colorectal Neoplasms Interaction[upregulation of microRNA-214-3p] RNA Pull-Down//qRT-PCR//Luciferase Report Assay//Western Blot Microarray expression profiles were used to screen colorectal cancer (CRC)-related differentially expressed genes and lncRNAs, which revealed that insulin receptor substrate 1 (IRS1) and lncRNA plasmacytoma variant translocation 1 (PVT1) were highly expressed in CRC. Microarray expression profiles were used to screen colorectal cancer (CRC)-related differentially expressed genes and lncRNAs, which revealed that insulin receptor substrate 1 (IRS1) and lncRNA plasmacytoma variant translocation 1 (PVT1) were highly expressed in CRC. No 31125260 PRR7-AS1-204 LncRNA Homo sapiens Adrenocortical Carcinoma ACC tissues Expression[highly expressed] qRT-PCR//Microarray In these samples, 874 lncRNAs were differentially expressed in ACC compared with NAC, of which 409 were upregulated, and 465 were downregulated. The 874 differentially expressed lncRNAs corresponded to 330 annotated lncRNA genes. Among the upregulated lncRNAs, the greatest log2 fold change was 8.5 for an unannotated lncRNA gene, and RAD50 was the geratest upregulated, annotated lncRNA gene with a log2 fold change of 6.1. Among the downregulated lncRNAs, the greatest log2 fold change was 8.3 for an unannotated lncRNA gene and 6.4 for HAND2, the greatest downregulated annotated lncRNA gene; of these, 183 differently expressed lncRNAs had established functions in cancer development and cancer progression. Selected carcinogenesis-related lncRNAs are summarized in Table 2. No 31522749 PURPL LncRNA Homo sapiens Carcinoma, Ovarian Epithelial ovarian cancer tissues Interaction(miR-338-3p) qRT-PCR PURPL could target miR-338-3p, PURPL were upregulated in ovarian cancer tissues, upregulation of PURPL in ovarian cancer was negatively related with the recurrence free survival (RFS) and overall survival (OS), which were indicated by biomedical databases query. Our data showed upregulations of PURPL were noted in ovarian cancer tissues. Poor RFS (χ2=19.410, P=0.0002) and OS (χ2=17.600, P=0.0005) were found in patients with high level PURPL and low level miR-338-3p expressions. Higher expressions of PURPL were associated with more advanced FIGO stage and developed lymph node metastasis in epithelial ovarian cancer. No 34405027 PTTG3P LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR The levels of serum HULC, MALAT1, Linc00152, PTTG3P, SPRY4-IT1, UBE2CP3, and UCA1 were significantly higher in HCC patients than in patients with benign liver diseases and healthy controls, whereas serum PTENP1 was significantly decreased in HCC patients compared with healthy participants. No 32733618 PTTG3P LncRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissues regulation[PTTG3P/miR-132/212-3p/FoxM1 feedback loop] qRT-PCR Here, we found that PTTG3P was significantly upregulated in PDAC tissues.Taken together, our findings suggest that PTTG3P promotes PDAC progression through PTTG3P/miR-132/212-3p/FoxM1 feedforward circuitry and it may serve as a promising diagnostic marker or target for treatment in PDAC patients. Elevated PTTG3P expression correlated with larger tumor size and worse differentiation, and reduced overall survival. No 33298873 PTPRM-207 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[lower expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 PTPRJ-AS1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 PTPRG-AS1 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissue Expression[highly expressed] qRT-PCR We confirmed that the expressions of PTPRG-AS1 were distinctly higher in the EOC tissue compared with the adjacent non-tumor specimens (p < 0.01). Higher levels of PTPRG-AS1 in EOC patients were associated with advanced FIGO stage (p = 0.005), grade (p = 0.006), and distant metastasis (p = 0.005). Survival analyses revealed that patients with high expressions of PTPRG-AS1 had a distinctly decreased overall survival (p = 0.0029) and disease-free survival (p = 0.0009) compared with those with low expressions of PTPRG-AS1. Multivariate assays indicated that PTPRG-AS1 expression was an independent prognostic factor for both overall survival and disease-free survival in EOC (Both p < 0.05). No 32844927 PTPRC-217 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PTPN11 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 PTK7 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PTK6 LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-26A) Expression[lower expressed] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD20 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 PTGES2-AS1-201 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[highly expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 7. No 31619123 PTGER4P2-CDK2AP2P2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 PTENP1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[PTENP1/miR-20a/PTEN axis ] Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Invasion Assay//IF PTENP1 showed a lower level in tumor tissues relative to the paired adjacent tissues (Fig. 1a). ollectively, these data indicated that PTENP1/miR-20a/PTEN axis involved in the malignant behaviors of BC cells, illuminating the possible mechanism mediated by PTEN via PI3K/Akt pathway. Targeting PTENP1/miR-20a/PTEN may provide a potential diagnosis and treatment strategy for BC. No 31196157 PTENP1 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[lower expressed] qRT-PCR The levels of serum HULC, MALAT1, Linc00152, PTTG3P, SPRY4-IT1, UBE2CP3, and UCA1 were significantly higher in HCC patients than in patients with benign liver diseases and healthy controls, whereas serum PTENP1 was significantly decreased in HCC patients compared with healthy participants. No 32733618 PTENP1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Mutation[rs7853346 ] Genotyping The results of this research showed that rs7853346 [Additive model: Adjusted odds ratio (OR) = 0.81, 95% confidence interval (CI) = 0.66-0.99] was related to the OSCC risk. No 30229832 PTCSC3 LncRNA Homo sapiens Periodontitis periodontal ligament stem cells Interaction[TLR4 ] qRT-PCR//Western Blot In this study we found that PTCSC3 was downregulated, while toll-like receptor 4 (TLR4) was upregulated in periodontal ligament stem cells (PDLSCs) isolated from periodontitis affected teeth that in PDLSCs isolated from healthy teeth. Therefore, lncRNA PTCSC3 may regulate the proliferation of PDLSCs and TLR4 expression to improve periodontitis. No 31196168 PSORS1C3 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)28) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 PSORS1C3 LncRNA Homo sapiens Adenocarcinoma of Lung otherwise non-metastasis and healthy adults Regulation RNA-seq LncRNA family with sequence similarity 66 member A (FAM66A) and lncRNA PSORS1C3 were found to be associated with tumor metastasis. LncRNA family with sequence similarity 66 member A (FAM66A) and lncRNA PSORS1C3 were found to be associated with tumor metastasis. No 36388820 PSME3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PSMD6-AS2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PSMB8-205 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PSMB3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PSMA6-212 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PSMA3-AS1 LncRNA Homo sapiens Sjogren's Syndrome PBMCs of 30 patients with pSS and 15 healthy persons Expression(highly expressed) qRT-PCR//Bioinformatics Analysis Real-time PCR revealed that GABPB1-AS1 and PSMA3-AS1 were significantly up-regulated 3.0- and 1.4-fold in the pSS group, respectively. The GABPB1-AS1 expression level was positively correlated with the percentage of B cells and IgG levels. No 34284720 PSMA3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PSG8-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PSCA LncRNA Homo sapiens Stomach Neoplasms tumor Interaction(DDX5) In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Wound Healing Assay//Co-IP//CCK8//qRT-PCR//RIP//ChIP-seq//RNA-seq//Colony Formation Assay//Transwell Assay Here, we functionally characterize a lncRNA, lncPSCA, as a novel tumor suppressor whose expression is fine-regulated by a gastric cancer risk-associated genetic variant. LncPSCA interacts with DDX5 and promotes DDX5 degradation through ubiquitination. Increased expression of lncPSCA results in low levels of DDX5, less RNA polymerase II (Pol II) binding with DDX5 in the nucleus, thus activating transcription of multiple p53 signaling genes by Pol II. No 34472665 PRSS23 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PRSS21 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PRRT3-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PTTG3P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PURPL LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR Expression of PURPL was significantly upregulated in 50 GC samples as well as in GC tissues from GSE13911 and GSE27342 datasets. Our results demonstrated that PURPL RNA level in GC was significantly related to tumor size and histopathological grade. No 31606380 PVT1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR IncRNA PVT1 was overexpressed in CRC tissues compared to paired-adjacent normal tissues and the high expression rate was 72.31%. High expression of lncRNA PVT1 predicts a later tumor stage (p = 0.001), poorer tissue differentiation (p = 0.019), and higher plasma CEA level (p = 0.043). Additionally, the lncRNA PVT1 expression was closely related to lymph node metastasis (N1/N2 vs. N0) and distant metastasis (M1 vs. M0) in CRC patients (p = 0.002; p = 0.003), but not to tumor T classification (p = 0.314). No 31850702 PVT1 LncRNA Homo sapiens Myocardial Reperfusion Injury myocardial I/R tissue specimens Expression(highly expressed) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//ELISA//IHC//IF LncRNA PVT1 was markedly up-regulated in myocardial I/R tissue specimens as well as H/R-induced H9C2 cells. Silencing PVT1 significantly lowered serum levels of cTnI, LDH, BNP, and CK-MB in myocardial I/R mice. H&E and Masson staining showed that silencing PVT1 alleviated myocardial I/R injury. PVT1 knockdown significantly lowered the production and release of inflammatory factors as well as inhibited the expression of GSDMD-N and Caspase1 in myocardial I/R tissue specimens as well as H/R-induced H9C2 cells. No 34595225 PVT1 LncRNA Homo sapiens Colorectal Neoplasms Colorectal Cancer tissues Mutation[rs1252200336 ] Genotyping The risk of developing CRC in subjects with the ID genotype of the PVT1 gene locus rs1252200336 was 2.71 times higher compared with the type II genotype; and the D allele was a risk factor for CRC. The survival of CRC patients with the ID/DD genotypes of the PVT1 gene rs1252200336 locus was significantly lower compared with the II genotype. In both the cancerous tissues and the paracancerous normal tissues of CRC patients, the level of lncRNA PVT1 was negatively correlated with the hsa-miR-455-5p and hsa-miR-455-3p levels. In subjects carrying the ID/DD genotypes of the PVT1 gene rs1252200336 locus, the level of the lncRNA PVT1 in cancerous tissues was significantly higher compared with the II genotype, whereas the hsa-miR-455-3p level was significantly lower compared with the II genotype. No 31509024 PVT1 LncRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR Our data revealed that the expression levels of lncRNAs 91H, PVT-1 and MEG3 were significantly higher in plasma samples from CRC patients than in those from non-cancerous controls. No 30978169 PVT1 LncRNA Homo sapiens Colorectal Neoplasms CRC and AP patients Mutation(rs13255292 ) qRT-PCR//ELISA Serum PVT1 and MALAT1 were upregulated in CRC and AP patients versus healthy controls, whereas, miRNA-186, miRNA-101 and E-cadherin were downregulated in CRC versus non-CRC groups. For the first time, rs13255292 and rs3200401 are potential genetic CRC predisposition markers, with rs3200401 possibly impacting the EMT process. PVT1, MALAT1, miRNA-186 and miRNA-101 levels were correlated with E-cadherin, tumor stage, lymph node and distant metastasis. No 34200314 PVT1 LncRNA Homo sapiens Osteoarthritis OA patients and IL-1β-stimulated chondrocytes interaction[miR-149] Flow Cytometry//qRT-PCR//Western Blot In the present study, high expression of PVT1 was observed in cartilage of OA patients and IL-1β-stimulated chondrocytes.Further molecular mechanism analysis identified PVT1 as an endogenous sponge RNA that could directly bind to miR-149 and repress its expression and activity. No 30126849 PVT1 LncRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma tissues Interaction[sponging microRNA-365] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//IF Our study found PVT1 levels were markedly up-regulated in the corresponding HCC tissues.Importantly, we found that PVT1 could facilitate cell autophagy in HCC cells. Then, we confirmed that the effect of PVT1 promoting autophagy was dependent on regulating ATG3 expression. Further investigations revealed that PVT1 could upregulate autophagy-related gene 3 (ATG3) expression by acting as an endogenous sponge of miR-365, which was an inhibitor gene on ATG3 protein by targeting 3'UTR of ATG3 mRNA. Moreover, rescue assays indicated that the effect of PVT1 on autophagy of HCC cells were dependent on miR-365. No 30794914 PVT1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Interaction[binding to miR-140] RNA Pull-Down//qRT-PCR//MTT//Luciferase Report Assay Compared to that in the normal tissues, the expression level of PVT1 was higher in the tumor tissues of ovarian cancer patients with statistical significance (Fig. 2a). Furthermore, the later the tumor stage, the higher the expression level of PVT1 (Fig. 2c). According to the overall survival analysis illustrated in Fig. 2b, the ovarian cancer patients with higher PVT1 expression levels displayed poorer survival outcomes. No 31222482 PVT1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Expression[highly expressed] qRT-PCR//MeRIP//RNA Pull-Down//RIP In this study, we found that PVT1 expression was upregulated in OS tissues and cells and significantly related with clinical stage, tumor size, and prognosis of patients with OS. In this study, we found that PVT1 expression was upregulated in OS tissues and cells and significantly related with clinical stage, tumor size, and prognosis of patients with OS. No 32021563 PVT1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cells Interaction(PVT-1/TRIM28 axis) Co-IP . A subgroup of tumors harbor amplification of chromosome 8q24.2 and increased expression of the oncogenic long noncoding RNA (lncRNA) Plasmacytoma Variant Translocation-1 (PVT-1), which is associated with an extremely poor clinical prognosis. Chromatin Hybridization by RNA Purification analysis identified Tripartite-Motif Containing Family 28 (TRIM28) as a novel PVT-1 binding partner. Mechanistically, co-immunoprecipitation studies showed the PVT-1/TRIM28 complex binds and increases SUMOylation of phosphatidylinositol 3-kinase catalytic subunit type 3 (Vps34), which leads to enhanced ubiquitination and degradation of tumor suppressor complex 2 (TSC2), thus contributing to increased self-renewal and stem cell phenotypes. . A subgroup of tumors harbor amplification of chromosome 8q24.2 and increased expression of the oncogenic long noncoding RNA (lncRNA) Plasmacytoma Variant Translocation-1 (PVT-1), which is associated with an extremely poor clinical prognosis. No 36348010 PVT1 LncRNA Homo sapiens Leukemia, Myeloid, Acute blood Expression[highly expressed] qRT-PCR We investigated the expression levels of LncRNAs in 70 patients; 30 with t(8;21) positive AML and 40 with t(8;21) negative AML, We found that CCAT1 and PVT1 are expressed in higher levels in t(8;21) positive -AML by 5.3 folds compared to t(8;21) negative group; the expression values were significantly associated with high-risk clinical criteria; moreover, they are associated with lower overall survival (OS) rate and leukemia-free survival (LFS), however we didn't find a statistically significant cut-off value of LncRNAs using the Cox regression analysis for Lnc_PVT1 except with LFS, we conclude that high expression levels of CCAT1 and PVT1 are associated with poor prognosis while being poor prognostic biomarkers in t(8;21) associated AML. We investigated the expression levels of LncRNAs in 70 patients; 30 with t(8;21) positive AML and 40 with t(8;21) negative AML, We found that CCAT1 and PVT1 are expressed in higher levels in t(8;21) positive -AML by 5.3 folds compared to t(8;21) negative group; the expression values were significantly associated with high-risk clinical criteria; moreover, they are associated with lower overall survival (OS) rate and leukemia-free survival (LFS), however we didn't find a statistically significant cut-off value of LncRNAs using the Cox regression analysis for Lnc_PVT1 except with LFS, we conclude that high expression levels of CCAT1 and PVT1 are associated with poor prognosis while being poor prognostic biomarkers in t(8;21) associated AML. No 30943439 PVT1 LncRNA Homo sapiens Uterine Cervical Neoplasms plasma Expression[highly expressed] qRT-PCR We discovered 4 lncRNAs including HOTAIR, PVT1, XLOC_000303, and AL592284.1, which were upregulated in CC comparing with the cancer-free controls. No 30134241 PVT1 LncRNA Homo sapiens Glioma glioma tissues Expression[highly expressed] qRT-PCR The expression levels of PVT1 were significantly higher in glioma tissues than in normal tissues (p< 0.01) and higher in high grade (III-IV) than in low grade (I-II) tumors (p< 0.01). The expression levels of PVT1 were significantly higher in glioma tissues than in normal tissues (p< 0.01) and higher in high grade (III-IV) than in low grade (I-II) tumors (p< 0.01). Analysis showed that the PVT1 level was closely related to glioma grade (p< 0.01), but not to age, gender, Karnofsky performance status (KPS) and tumor size (p> 0.05). Receiver operator characteristic curve analysis showed an area under the curve of 0.835. Log-rank test showed that the prognosis of high PVT1 group was poorer than that of low PVT1 group (p< 0.01). No 30909189 PVT1 LncRNA Homo sapiens Pancreatic Neoplasms PC cells regulation[YKT6, RAB7, and VAMP3 ] RNA Pull-Down//Western Blot//qRT-PCR//RIP//IF The results showed that PVT1 was upregulated in PC cells, along with increased levels of YKT6 v-SNARE homolog (YKT6), ras-related protein Rab-7 (RAB7), and vesicle-associated membrane protein 3 (VAMP3). No 32499447 PVT1 LncRNA Homo sapiens Prostatic Neoplasms Mutation[rs12680047] Genotyping Three SNPs (rs9642880, rs16902359, and rs12680047) and 79 SNP-SNP pairs were significantly associated with prostate cancer risk. These two SNPs (rs16902359 and rs9642880) in CASC11 interacted frequently with other SNPs with 56 and 9 pairs, respectively. No 30914434 PVT1 LncRNA Homo sapiens Prostatic Neoplasms tumor tissues Expression(highly expressed) RNA-seq The expression of PTV1 in tumor tissues was significantly higher than that in normal tissues(P<2.2e-16). The difference of PTV1 expression was observed according to vital status (P = 0.0051) and Gleason score (P = 0.0012). The expression of PTV1 is significantly associated with T classification (P < 0.0001), N classification (P = 0.0499), PSA (P = 0.0001), Gleason Score (P < 0.0001), targeted molecular therapy (P = 0.0264) and vital status(P = 0.0036). The difference of PTV1 expression was observed according to vital status (P = 0.0051) and Gleason score (P = 0.0012). The expression of PTV1 is significantly associated with T classification (P < 0.0001), N classification (P = 0.0499), PSA (P = 0.0001), Gleason Score (P < 0.0001), targeted molecular therapy (P = 0.0264) and vital status(P = 0.0036). No 33752525 PVT1 LncRNA Homo sapiens Diabetes Mellitus, Type 2 Brazilian population Interaction(rs3931283) Genotyping The rs3931283/PVT1 G/G and rs7158663/MEG3 G/G are associated with DKD and markers of renal function in T2DM patients from a Brazilian population. No 36565414 PVT1 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Expression[highly expressed] Cell Proliferation Assay//qRT-PCR//Flow Cytometry//Western Blot The expression of PVT1 in ccRCC was analyzed using reverse transcription-quantitative polymerase chain reaction, and it was revealed that PVT1 expression was upregulated in ccRCC tissues compared with that in normal adjacent tissues. Next, PVT1 expression from The Cancer Genome Atlas datasets was validated, and it was also revealed that the high expression of PVT1 was associated with advanced disease stage and a poor prognosis. No 29725475 PVT1 LncRNA Homo sapiens Endometrial Neoplasms Serum and tissue samples Expression(lower expressed) RNA-seq At the same time, lncRNA sequencing results showed that when endometrial atypical hyperplasia continued to change, including LINC00511, PVT1, and IQCH-AS1 (downregulated), and only changed significantly in the endometrial dysplasia group, including MALAT1, CARMN (downregulated) and LINC00648, BISPR, LINC01534, and LINC00930 (upregulated). No 36510632 PVT1 LncRNA Homo sapiens Coronary Artery Disease serum Expression[highly expressed] qRT-PCR It was found that PVT1 was highly expressed in the serum of CAD patients and its level was correlated with Gensini score (r=0.761, p=0.023). No 32572930 PVT1 LncRNA Homo sapiens Rhinitis, Allergic allergic rhinitis children Expression(highly expressed) qRT-PCR Lnc-PVT1 was upregulated in AR children compared with DCs and HCs (both p < 0.001). Lnc-PVT1 negatively associated with Th1 cells in AR children (p = 0.028) also exhibited a negative correlation trend with IFN-γ (but without statistical significance) (p = 0.065). Differently, lnc-PVT1 was positively related to Th2 cells (p = 0.012) and IL-10 (p = 0.021) in AR children. Besides, lnc-PVT1 and TNSS were reduced at W4 after treatment in AR children (both p < 0.001); notably, lnc-PVT1 expression decline was correlated with TNSS decline during treatment (p = 0.013). Lnc-PVT1 was positively related to nasal rhinorrhea score, itching score, congestion score, and total nasal symptom score (TNSS) in AR children (all p < 0.050), instead of sneezing score (p = 0.115). No 35274773 PVT1 LncRNA Homo sapiens Essential Hypertension Chinese Population Mutation(rs10956390, rs80177647 ) Genotyping PVT1 rs10956390 and rs80177647 polymorphisms were genotyped by using TaqMan assay. PVT1 rs10956390 TT genotype was associated with a decreased risk of EH (OR = 0.561, 95% CI = 0.372-0.846, P = 0.006), while rs80177647 TA genotype was associated with an increased risk (OR = 2.236, 95% CI = 1.515-3.301, P < 0.001). Rs10956390 T allele was associated with lower triglyceride levels in the plasma both from healthy and EH donors. What is more, there is an association between rs10956390 polymorphism and HDL-C level, as well as LDL-C. No 35036445 PVT1 LncRNA Homo sapiens Arthritis, Rheumatoid synovial tissues interaction[targeting miR-145-5p] Tunel//Flow Cytometry//qRT-PCR//MTT//ELISA//EdU Staining PVT1 was significantly increased and miR-145-5p was decreased in synovial tissues of RA patients. PVT1 can regulate apoptosis and inflammatory responses in RA-FLSs by targeting miR-145-5p. No 32918701 PVT1 LncRNA Homo sapiens Arthritis, Rheumatoid serum Regulation(miRNA-146a) qRT-PCR Lnc-PVT1 expression level was greater among patients with RA compared to that of OA patients, with a fold change median of 2.62 and 0.22, respectively (p = 0.001). The miR-146a fold change was significantly demonstrated between the RA, OA, and HCs groups. There was no correlation between both biomarkers with the disease activity scales (DAS28) of RA, the Knee injury Osteoarthritis Outcome Score (KOOS), or any sign of detection of the disease severity of OA. There was no correlation between both biomarkers with the disease activity scales (DAS28) of RA, the Knee injury Osteoarthritis Outcome Score (KOOS), or any sign of detection of the disease severity of OA. No 34947913 PVT1 LncRNA Homo sapiens Solid Tumors Expression[highly expressed] Meta-analysis Subgroup analysis showed that the high expression of PVT1 was closely related to the low overall survival rate of patients with clear cell renal cell carcinoma, breast cancer, cervical cancer, colon cancer, epithelial ovarian cancer, gastric cancer, lung cancer, and osteosarcoma. No 31277104 PVT1 LncRNA Homo sapiens Coronary Disease 464 CHD patients and 510 healthy controls Mutation(rs4410871) Genotyping The study displayed the contribution of CASC8, CASC11, and PVT1 genetic polymorphisms to CHD predisposition, and these variants could serve as potential biomarkers of CHD susceptibility.CASC11 rs9642880 (OR = 1.49, P = 0.021) was a risk factor for increased CHD susceptibility in subjects over 60 years old, and PVT1 rs4410871 was a protective factor for CHD susceptibility in males (OR = 0.67, P = 0.015) and smokers (OR = 0.62, P = 0.047). No 34001726 PVT1 LncRNA Homo sapiens Myelodysplastic Syndromes bone marrow Expression[highly expressed] qRT-PCR//Microarray Of the functionally described lncRNAs, we detected the upregulation of H19, EMCN-IT1, WT1-AS, MEG8, and PVT1 and the downregulation of ST6GAL2-IT1 and U7. No 32977510 PVT1 LncRNA Homo sapiens Pulmonary Disease, Chronic Obstructive blood Expression[highly expressed] qRT-PCR Lnc-PVT1 expression was highest in AECOPD patients, followed by stable COPD patients and HCs. No 32342557 PVT1 LncRNA Homo sapiens Renal Insufficiency, Chronic CHF patients Expression(lower expressed) qRT-PCR Plasma PVT1 was downregulated in CHF and further downregulated in CHF patients complicated with progressive CKD. ROC curve analysis showed that plasma PVT1 levels could be used to distinguish CHF patients complicated with CKD from CHF patients without CKD and healthy controls. During a 2-year follow-up, patients with high CHF levels had a low incidence of progressive CKD among CHF patients. Moreover, with the treatment of progressive CKD, plasma PVT1 was upregulated. No 34563213 PVT1 LncRNA Homo sapiens Hyperparathyroidism, Primary 11 with parathyroid cancer (PC) and 46 with parathyroid adenoma (PA). Expression [highly expressed] qRT-PCR Higher levels of lncRNA score and PVT1 expression were associated with increased serum calcium level after water ingestion and PC risk (P < 0.05). Accordingly, lncRNA score and PVT1 expression were increased with varying degrees of hypercalcemia in PC. No 33910638 PVT1 LncRNA Homo sapiens Endometrial Neoplasms TCGA Interaction(miR-612/CENP-H/CDK1 axis ) In Vivo Experiment//Western Blot//ISH//Transfection//Wound Healing Assay//Invasion Assay//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//IHC//Bioinformatics Analysis//Transwell Assay The bioinformatics analysis showed that PVT1/miR-612/CENP-H/CDK1 axis played a vital role in the malignant progression of advanced EC. No 33948369 PCAT1 LncRNA Homo sapiens Lung Neoplasms blood Mutation[ rs1026411 and rs710886] Genotyping " However, polymorphisms in rs1026411 and rs710886 were observed to have significant associations with susceptibility to non-small cell lung cancer (AG vs. GG: odds ratio [OR]®a = 0.701, p* = 0.020 and AA+AG vs. GG: ORa = 0.711 [superscript ""a"" refers to OR adjusted by age, gender, and smoking], p* = 0.017 [asterisks ""*"" refers to p adjusted by age, gender, and smoking] for rs1026411; CT vs. TT: ORa = 0.723, p* = 0.047 and CC+CT vs. TT: ORa = 0.729, p* = 0.038 for rs710886). Besides, the rs1026411 polymorphism had a similar association with lung adenocarcinoma risk (AG vs. GG: ORa = 0.663, p* = 0.019 and AA+AG vs. GG: ORa = 0.685, p* = 0.020). Polymorphisms in rs710886 and rs16901904 were observed to be associated with lung squamous cell carcinoma risk (CC+CT vs. TT: ORa = 0.638, p* = 0.040 for rs710886; CC vs. TT: ORa = 2.582, p* = 0.033 and CC vs. TT+CT: ORa = 2.381, p* = 0.048 for rs16901904). In addition, there were no significant results in gene-environmental interactions in both additive and multiplicative models. Our results suggested that polymorphisms in lncRNA-PCAT1 might be associated with lung cancer susceptibility in a northeastern Chinese population. The results of gene-environmental interactions were not significant in lung cancer." No 31464517 PCAT1 LncRNA Homo sapiens Colorectal Neoplasms blood Mutation[rs2632159 ] Genotyping In the present study, PCAT1 rs2632159 polymorphism increased CRC risk by 1.37-fold and 2.19-fold in the dominant and recessive models, respectively (P=0.040 and 0.041). When the CRC cases were divided into colon cancer and rectal cancer, we found that this polymorphism affected colon cancer risk under the dominant model (P=0.022, OR = 1.51) and affected rectal cancer susceptibility under the recessive model (P=0.009, OR = 3.03). A more pronounced effect was observed in the male subgroup in that PCAT1 rs2632159 SNP increased rectal cancer risk by 3.97-fold (P=0.017). When PCAT1 rs2632159 was present, epistatic effects were observed with rs1902432 and rs785005 (P=0.011 and 0.008, respectively). eQTL analysis showed that rs2632159 could influence binding with the transcription factors EBF, LUN-1, and TCF12. No 31253700 PCAT1 LncRNA Homo sapiens Colorectal Neoplasms tumor and normal tissues regulation[GRWD1/RPL11/MDM2 axis ] qRT-PCR We identified a novel long noncoding gene (PiHL, P53 inHibiting LncRNA) from 8q24.21 as a p53 negative regulator. PiHL is drastically upregulated in CRC and is an independent predictor of CRC poor prognosis. Mechanistically, PiHL acts to promote p53 ubiquitination by sequestering RPL11 from MDM2, through enhancing GRWD1 and RPL11 complex formation. No 31903119 NONHSAT243351.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT240231.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT240181.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT239932.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT239094.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT239063.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT239041.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT238616.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT238209.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT237477.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT237164.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT236568.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT236031.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT235705.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT235324.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT235236.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT234993.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT234271.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT233151.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT231328.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT230563.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT230444.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT230307.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT228836.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT228140.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT228054.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT225524.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT223895.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT223051.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT222300.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT242257.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT243581.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT217756.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT247091.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONRATT011944.2 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[lower expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 NONRATT011770.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[highly expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT011539.2 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[lower expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 NONRATT011382.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[lower expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT011006.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[highly expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT009769.2 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[lower expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 NONRATT009275.2 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[highly expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 NONRATT009275.2 LncRNA Rattus norvegicus Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension Rat Models Regulation In Vivo Experiment//qRT-PCR//Transfection//Flow Cytometry Further, the expression levels of lncRNAs (NONRATT018084.2, NONRATT009275.2, NONRATT007865.2, and NONRATT026300.2) and mRNAs (LGALS3, PDGFC, SERPINA1, and NFIL3) were confirmed using quantitative real-time PCR. In the end, lncRNA NONRATT009275.2 could facilitate macrophage polarization to M2 type and be involved in inflammatory immune response. No 34267668 NONRATT008127.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[lower expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT007865.2 LncRNA Rattus norvegicus Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension Rat Models Regulation In Vivo Experiment//qRT-PCR//Transfection//Flow Cytometry Further, the expression levels of lncRNAs (NONRATT018084.2, NONRATT009275.2, NONRATT007865.2, and NONRATT026300.2) and mRNAs (LGALS3, PDGFC, SERPINA1, and NFIL3) were confirmed using quantitative real-time PCR. In the end, lncRNA NONRATT009275.2 could facilitate macrophage polarization to M2 type and be involved in inflammatory immune response. No 34267668 NONRATT007737.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[lower expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT006104.2 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[highly expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 NONRATT002987.2 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[highly expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 NONRATT002575.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[highly expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT001894.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[highly expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT001412.2 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[lower expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 NONO-209 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 NONHSAT257306.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT256947.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT255712.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT254902.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT254297.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT253077.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT249921.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT249585.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT249490.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT249191.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT248508.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT248435.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT221279.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT215760.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONRATT015712.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[lower expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONHSAT187505.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT186987.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT185165.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT184725.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT182106.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT182018.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT181500.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT181097.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT180518.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT180440.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT180241.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT179991.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT178815.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT177640.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT177424.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT176942.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT175998.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT172819.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT172363.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT172067.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT170313.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT169547.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT169379.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT168924.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT167947.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT165012.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT162018.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT161665.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT161250.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT161143.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT187424.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT187625.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT215688.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT187986.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT213964.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT210135.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT208559.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT205684.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT205148.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT204786.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT203741.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT203522.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT203023.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT202731.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT202671.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT201647.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT200911.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT200068.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT198457.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT198396.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT198072.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT197978.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT197222.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT197122.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT197031.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT194833.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT193889.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT193704.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT192306.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT192208.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT190138.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT188665.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONHSAT188610.1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NONRATT015512.2 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[highly expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 NONRATT016740.2 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[highly expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 PCAT1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck oral tissue Expression[highly expressed] qRT-PCR The expression of PCAT-1 and c-Myc were up-regulated in OSCC Significant different levels of PCAT-1 were found between the high risk habit (alcohol and tobacco) group and low risk habit group, between patients with cervical lymphnode metastasis and patients without cervical lymphnode metastasis. No 31081003 PAM LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 PABPC4-217 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 PABPC1-207 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 P4HB-207 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 P4HA2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 P2RX5-TAX1BP3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 P2RX4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 OXCT1-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms cell lines Regulation[miR-455-5p/JAK1 signaling] CCK8//qRT-PCR//Luciferase Report Assay//Microarray//Transwell Assay lncRNA OXCT1-AS1, which elevated in metastasis lymph node, was significantly upregulated in BCa cell lines compared with SVHUC-1.We demonstrated OXCT1-AS1 inhibited miR-455-5p to decrease its binding to the JAK1 3'-untranslated region, which could upregulate the expression of JAK1 at the protein level, thus promoting BCa proliferation and invasion. Therefore, lncRNA OXCT1-AS1 could act as a potential biomarker and therapeutic target for patients with BCa. No 30609030 OXCT1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines regulation[Circ-OXCT1/miR-136/SMAD4 Axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay Circ-OXCT1 was downregulated in GC tissues and cell lines. The clinicopathologic data analysis revealed that circ-OXCT1 overexpression could be a novel treatment for advanced GC especially with distant metastasis by targeting the circ-OXCT1/miR-136/SMAD4 axis. Its expression level was significantly associated with lymph node metastasis, pathologic stage and overall survival rate through clinicopathologic data analysis. No 32523351 OTX2-AS1 LncRNA Homo sapiens lung squamous cell carcinoma TCGA(409 LSCC and 49 control samples) Regulation Bioinformatics Analysis Kaplan-Meier survival curves revealed prognostic capabilities for three of these lncRNAs (LINC02555, APCDD1L-DT and OTX2-AS1). A Cox regression analysis revealed this three-lncRNA signature to be significantly associated with patient survival. A Cox regression analysis revealed this three-lncRNA signature to be significantly associated with patient survival. No 33910626 OTUD6B-AS1 LncRNA Homo sapiens Scleroderma, Systemic SSc skin biopsies Expression[lower expressed] BrdU//ELISA//qPCR//Western Blot Our recent screening experiments by RNA sequencing showed that ovarian tumor domain containing 6B antisense RNA1 (OTUD6B-AS1) and its sense gene OTUD6B were significantly downregulated in SSc skin biopsies. No 31156645 OTTHUMT00000076953 LncRNA Homo sapiens Brain Injuries, Traumatic Brain tissues Expression[lower expressed] qRT-PCR//Microarray LncRNA and mRNA expression profiles were detected in three TBI and three control groups. Volcano plot filtering identified 99 differentially expressed lncRNAs (P < 0.05, fold change > 1.2) (Figure ​1A1A and ​andB).B). Among them, 43 lncRNAs were up-regulated and 56 lncRNAs were down-regulated. In the TBI group, n333955, n332943, n335470, ENST00000384390, and n341115 were the five most significantly up-regulated lncRNAs. While, TCONS_00018733-XLOC_008489, OTTHUMT00000076953, NR_029967, ENST00000433249, and n381234 were the five most significantly down-regulated lncRNAs (Table 3). Next, we compared mRNA expression profiles of the TBI group with the control group. No 30632503 OSER1-DT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Peripheral Blood Expression(lower expressed) qRT-PCR//Luciferase Report Assay OSER1-AS1 was low in peripheral blood of patients with LUSC and LUAD. In LUSC and LUAD, OSER1-AS1 deficiency was associated with tumor node metastasis stage, lymph node metastasis, distal metastasis, and poor prognosis. No 34525476 OSBPL9P4 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 988 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 OSBPL8-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 ORC6 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 OR7K1P LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 708 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 OR7E2P LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1081 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 OR7E14P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 OR4F13P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 OR3A4P LncRNA Homo sapiens Osteosarcoma tumour tissue,cell lines interaction[sponging miR-1227-5p] qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay We observed that the expression level of OR3A4 was upregulated in the tumour tissue of osteosarcoma patients (p < 0.001) and osteosarcoma cell lines (p < 0.01) compared with the normal adjacent tissue and a normal human foetal osteoblastic cell line, respectively. OR3A4 promotes osteosarcoma cell proliferation and invasion by sponging miR-1227-5p, which might be related to the metastasis of osteosarcoma and could be used as a potential prognostic biomarker and therapeutic target in osteosarcoma. The survival curve revealed that patients with high expression levels of OR3A4 had lower overall survival. Increased OR3A4 expression in osteosarcoma patients was associated with distant metastasis (p = 0.02) and advanced clinical stage (p < 0.001). No 32082982 Oprm1 LncRNA Mus musculus Myocardial Reperfusion Injury I/R injury model regulation[Oprm1/miR-30b-5p/CSE axis] qRT-PCR//Cell Viability Assay//Tunel LncRNA Oprm1 was significantly down-regulated in the I/R injury model.When administered with lncRNA Oprm1, increased endogenous H2S can reduce apoptosis and protect the myocardium from I/R injury via activating PI3K/Akt pathway and inhibiting HIF1-α activity. No 32437793 OIP5-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[lower expressed] qRT-PCR HULC, OIP5-AS1 and THRIL transcription quantities were significantly lower in gastric tumors compared to ANCTs (P values = .02, 0.02 and 0.007, respectively). No 31982396 OIP5-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer and paired adjacent tissue,cell lines (MCF‐7, MDA‐MB‐231, T47D, SK‐BR‐3 , BT‐549) Interaction[microRNA-2-129p] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay OIP5-AS1 was significantly Expression[Expression[up-expression]-expression]regulated in breast cancer tissues and in breast cancer cell lines, and OIP5-AS1 Expression[down-expression]regulation inhibited the malignant behavior of breast cancer in vitro and in vivo. For in-depth exploration of the mechanism of OIP5-AS1 in breast cancer, we found that expression of microRNA-129-5p(miR-129-5p), which was found to bind sites in the sequence of OIP5-AS1, in breast cancer tissues was negatively correlated with OIP5-AS1. Also, luciferase assays indicated that OIP5-AS1 acted as a miR-129-5p sponge, resulting in Expression[Expression[up-expression]-expression]regulated expression of the sex-determining region Y-box 2 (SOX2) transcription factor. Our study showed that OIP5-AS1 plays a critical role in promoting breast cancer progression and that OIP5-AS1 Expression[down-expression]regulation targets SOX2 by miR-129-5p Expression[Expression[up-expression]-expression]regulation. No 30443959 OIP5-AS1 LncRNA Homo sapiens Bipolar Disorder blood Expression[lower expressed] qRT-PCR CCAT2, TUG1 and PANDA were up-regulated in total BD patients compared with total healthy subjects (P values = 0.006, <0.001 and 0.004 respectively) while OIP5-AS1 was down-regulated (P = 0.001). No 30772744 OIP5-AS1 LncRNA Homo sapiens aortic valve disease aortic tissues Regulation[miR-137/TWIST11 axis] RNA Pull-Down//Western Blot//RIP//Luciferase Report Assay//PCR The results showed that downregulated expression of OIP5-AS1 was observed in human aortic VICs after osteogenic induction.Mechanistically, we further showed that OIP5-AS1 could relieve osteogenic differentiation of VICs via upregulating miR-137 target gene TWIST1. No 30846207 OIP5-AS1 LncRNA Homo sapiens Pulmonary Disease, Chronic Obstructive 16HBE cells Interaction(micro RNA -410-3p/IL-13) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//ELISA The expression of OIP5-AS1 and miR-410-3p was related to the ratio of FEV1 respectively. OIP5-AS1 might serve as a diagnostic biomarker. Interference of OIP5-AS1 restored the abnormal cell viability, apoptosis, and inflammation in cigarette smoke extract (CSE)-stimulated 16HBE cells by regulating miR-410-3p and IL-13. OIP5-AS1 appeared to be a biomarker for distinguishing COPD patients from smokers. OIP5-AS1/miR-410-3p/IL-13 exerted function on the cell viability, apoptosis, and inflammation in CSE-steered cell models. No 34872453 OGA CircRNA Homo sapiens Stomach Neoplasms blood Expression[lower expressed] qRT-PCR//circRNA-seq The top 5 up- and downregulated circRNAs in patients with are listed in Table IV. No 32765789 OBSL1-209 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 OBI1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PABPC5-AS1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 PAN3 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 NUTM2A-AS1-234 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 PANDAR LncRNA Homo sapiens Bipolar Disorder blood Expression[highly expressed] qRT-PCR CCAT2, TUG1 and PANDA were up-regulated in total BD patients compared with total healthy subjects (P values = 0.006, <0.001 and 0.004 respectively) while OIP5-AS1 was down-regulated (P = 0.001). No 30772744 PCAT1 LncRNA Homo sapiens Endometrial Neoplasms tissues and plasma from endometrial carcinoma Expression[highly expressed] qRT-PCR In this study, we demonstrated that long non-coding RNA PCAT1 is dramatically increased in the tissues and plasma from endometrial carcinoma (EC) (n = 100, all p < 0.001) controlled by its paracancerous tissue, and cell lines including RL-952, HEC-1-B, KLE, Ishikawa, and AN3CA compared to the cells from normal endometrium (all p < 0.001). No 31927050 PCAT1 LncRNA Homo sapiens Multiple Myeloma 83 symptomatic MM patients Expression(highly expressed) qRT-PCR Lnc-PCAT1 was increased in MM patients than in health donors (p < 0.001), and receiver operating characteristic (ROC) curve showed that lnc-PCAT1 had excellent capability of discriminating MM patients from health donors (area under curve: 0.932, 95% confidence interval: 0.889-0.976). In MM patients, lnc-PCAT1 was correlated with bone lesion (p = 0.024), higher β2 -MG (p = 0.005), LDH (p = 0.037), and presence of Del (17p) (p = 0.029). Lnc-PCAT1 was also associated with poor ISS stage (p = 0.013) and R-ISS stage (p = 0.005). No 34564896 PCAT1 LncRNA Homo sapiens Depressive Disorder, Major blood Expression[highly expressed] qRT-PCR Five were found to be differentially expressed in MDD patients compared to healthy subjects (Fig. 1, Supplemenatal Table 3): MER11C, PCAT1, PCAT29, RMRP, and Y5. Whereas the expression level of RMRP in MDD patients was significantly lower than in healthy subjects (p = 0.000227, U = 175), the expression levels of MER11C, PCAT1, PCAT29, and Y5 were significantly higher in MDD patients than in healthy subjects (MER11C: p = 0.0215, U = 262; PCAT1: p = 0.0183, U = 199; PCAT29: p = 0.00693, U = 165; Y5: p = 0.00665, U = 226). No 31351391 PCAT1 LncRNA Homo sapiens Prostatic Hyperplasia Expression[highly expressed] qRT-PCR The expression of PCAT1 was significantly higher in healthy subjects compared to BPH patients (p = 0.03). No 32529802 PCA3 LncRNA Homo sapiens Thyroid Carcinoma, Anaplastic Anaplastic Thyroid Carcinomas tissues Expression[highly expressed] qRT-PCR//Microarray Two of the upregulated lncRNAs, PCA3 and HAM-1, were analyzed on a thyroid carcinoma TMA. There was increased expression of both lncRNAs in ATCs and PTCs compared with NT after TMA analysis. qRT-PCR analyses showed increased expression of both lncRNAs in ATCs compared with NT and PTCs No 31468286 PBX4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PBB12 LncRNA Homo sapiens Osteosarcoma OS tissues Interaction[KLF4/hsa‑miR‑204‑5p/ATF2 pathway] qRT-PCR//IF//Luciferase Report Assay//Western Blot The level of PBB12 was significantly higher in OS with metastasis and adjacent tissues than that in OS without metastasis and adjacent tissues (P<0.01, vs. non-metastatic osteosarcoma and adjacent tissues), but there was no significant difference in the PBB12 level in tumors and autologous adjacent tissues in either type of OS (P>0.05; Fig. 1E). No 31894336 PAX8-AS1-202 LncRNA Homo sapiens artery disease blood Expression[lower expressed] qRT-PCR//Microarray Microarray analysis showed 23 differentially expressed lncRNAs in patients with poor LMCs status. After independent validations by RT-PCR, lncRNA ENST00000422956 was found to be significantly downregulated in patients with poor LMCs status. No 31807505 PAX8-AS1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 PAX8-AS1 LncRNA Homo sapiens Lymphoma, Non-Hodgkin 175 patients and 175 healthy subjects Mutation(rs4848320, rs1110839, rs6726151 ) PCR Results demonstrated rs4848320 C > T and rs6726151 T > G of PAX8AS1 and rs7158663 of MEG3 play a potential role in the susceptibility of NHL and PAX8AS1 rs1110839 T > G variant was associated with decreased risk of NHL. No 35938744 PASK LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)34) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 PART1 LncRNA Homo sapiens Stomach Neoplasms tissues Regulation qRT-PCR//RNA-seq The results of our study demonstrated that the five-lncRNAs PART1, UCA1, DIRC3, HOTAIR, and HOXA11AS require more investigation to be confirmed as diagnostic biomarkers in gastric cancer. No 35949302 PART1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PART1 LncRNA Homo sapiens Alzheimer Disease blood Expression[lower expressed] qRT-PCR Real-time quantitative reverse transcription PCR (qRT-PCR) assay revealed that PART1 was downregulated, while SNHG14 was upregulated in AD serum samples when compared to normal samples. No 33584243 PART1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 PARP6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PARP12 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PARP1 LncRNA Homo sapiens Glioma Mutation[rs1136410 ] Genotyping In addition, PARP1 rs1136410 variant genotype could be beneficial for the overall survival of patients with glioma. No 31489712 PARGP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PARD6G-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 PAQR9 LncRNA Homo sapiens Diabetic Nephropathies blood,cell lines Regulation[Nrf2/HO-1 and NF-κB pathways] qRT-PCR//ELISA//Western Blot Blnc1 has higher expression in serum of DN patients, STZ-induced DN model and HG-induced HK2 cells.Our present study suggested that Blnc1 can affect inflammation, oxidative stress and renal fibrosis by Nrf2/HO-1 and NF-κB pathways in DN. No 31632538 PAPPA-AS1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 879 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 PANTR1-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 PANTR1 LncRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues and cell lines Expression [highly expressed] qRT-PCR//Western Blot The level of Linc-POU3F3 mRNA expression was significantly higher in esophageal cancer tissues and cell lines than that in normal adjacent tissues and cell lines (all P<0.01). The expression of Linc-POU3F3 was correlated with the tumor progression and poor prognosis of esophageal cancer. No 34275926 PANDAR LncRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR Compared with healthy subjects, the levels of plasma lncRNAs PANDAR, FOXD2-AS1, and SMARCC2 were all significantly higher in gastric cancer patients (P<0.05). These lncRNAs were significantly associated with clinicopathological parameters of gastric cancer, like pathological differentiation, TNM stage, and/or lymph nodes metastasis, and/or invasion depth (P<0.05). The AUC for lncRNA PANDAR was 0.767, for FOXD2-AS1 was 0.700, for SMARCC2 was 0.748, and the AUC of the combinative diagnostic value of these three lncRNAs was 0.839. Adjusted by other variables, these lncRNAs' expressions were significantly associated with gastric cancer. No 31308753 PANDAR LncRNA Homo sapiens Breast Neoplasms a cohort of Iranian breast cancer patients Expression(lower expressed) Other Expression levels of TP53, MEG3, CASC2 and PANDA were significantly lower in tumoral samples compared with non-tumoral samples (Posterior mean differences = -4.26, -1.66, -5.98 and -3.13, respectively; P values < 0.0001).Expression of CASC2 was higher in Her2 1+ cases compared with Her2 negative cases (Beta = 1.85, P value = 0.037). Expression levels of MEG3 and TP53 were lower in grade 2 samples compared with grade 1 (Beta = -1.86, P value = 0.006 and Beta = -2.24, P value = 0.003, respectively). No 35034894 PANDAR LncRNA Homo sapiens Neoplasms Regulated[up-regulated] Meta-analysis A total of 1,132 cancer patients were enrolled in the present meta-analysis to assess the prognostic value of PANDAR in various carcinomas. Promoted PANDAR expression was demonstrated to significantly predict unfavorable OS (HR = 1.77, 95% CI: 1.12 - 2.80, p = 0.014) by the random effects model. According to the stratified analyses and meta-regression results, the heterogeneity of present analysis may be attributed to the differences of cancer resources. Furthermore, over-expression of PANDAR was revealed to be effectively predictive of cancer progression (HR = 1.70, 95% CI: 1.41 - 2.05, p < 0.00001) and LNM (HR = 1.71, 95% CI: 1.39 - 2.10, p < 0.00001). No 30775883 PANDAR LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 PANDAR LncRNA Homo sapiens Multiple Sclerosis peripheral blood Expression[highly expressed] qRT-PCR In the present study, we evaluated expression levels of three lncRNAs named Nuclear Paraspeckle Assembly Transcript 1 (NEAT1), P21 associated ncRNA DNA damage activated (PANDA) and Taurine-up-regulated gene 1 (TUG1) in peripheral blood of 50 relapsing-remitting MS patients and 50 matched healthy subjects. No 30114626 NYHA LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[lower expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 NUTM2A-AS1-210 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 NONRATT016766.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[lower expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NPSR1-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD specimens Expression(highly expressed) qRT-PCR We found that the expression of NPSR1-AS1 was much higher in LUAD specimens compared to nontumor tissues. It was determined by multivariate analysis that NPSR1-AS1 expressions served as an independent prognostic factor for the overall survival of LUAD patients. Patients with high levels of NPSR1-AS1 expression were shown to have a shorter disease-specific survival (DSS) or overall survival (OS) than those with low levels of NPSR1-AS1 expression, according to the findings of a clinical investigation. No 36284635 NPM1P7 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 870 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 NOTCH4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NOTCH2 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 Nostrill LncRNA Homo sapiens Cryptosporidium Parvum Infection AIDS patients Interaction( NF-κB p65/Irf7 ) In Vivo Experiment//qRT-PCR//RIP//ChIP In this study, we provide evidence that the lncRNA Nostrill is upregulated in the intestinal epithelium following infection by Cryptosporidium parvum, a globally prevalent apicomplexan parasite that causes significant diarrheal disease and an important opportunistic pathogen in the immunocompromised and AIDS patients. Induction of Nostrill in infected intestinal epithelial cells was triggered by NF-κB signaling and was observed to enhance epithelial defense by decreasing parasitic infection burden.Nostrill participates in the transcriptional regulation of C. parvum-induced Irf7 expression through interactions with NF-κB p65, and induction of Nostrill promotes epigenetic histone modifications and occupancy of RNA polymerase II at the Irf7 promoter. No 35464447 NORAD LncRNA Homo sapiens Breast Neoplasms BC cell lines and tissues Interaction(miR-155-5p/SOCS1 Axis) Western Blot//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//BrdU//Transwell Assay NORAD expression was significantly reduced in BC cell lines and tissues, and its low expression was associated with poor tumor tissue differentiation. Additionally, miR-155-5p was found to be a target of NORAD, and the biological functions of miR-155-5p and NORAD were counteractive. MiR-155-5p was confirmed to target SOCS1, and SOCS1 was found to be positively regulated by NORAD. NORAD expression was significantly reduced in BC cell lines and tissues, and its low expression was associated with poor tumor tissue differentiation. No 34190442 NORAD LncRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR We found that upregulation of LINC00657 and downregulation of miR-106a are significantly associated with the development of CRC. No 30927333 NORAD LncRNA Homo sapiens Colorectal Neoplasms CRC patient tissue interaction[as a miR-203a sponge] qRT-PCR LINC00657 expression resulted frequently up-regulated in CRC patient tissue,Furthermore, LINC00657 worked as a competing endogenous RNA (ceRNA) for miR-203a, antagonizing its function as a tumor suppressor and leading to the de-repression of CSCs invasion. LINC00657 expression resulted frequently up-regulated in CRC patient tissue, and high expression of LINC00657 was correlated with an advanced clinical stage, lymph node metastasis, distant metastasis and poor overall survival of CRC patients. No 32703458 NORAD LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC and para-carcinoma tissues Expression[Expression[lower expressed]-expression] qRT-PCR//Microarray The qRT-PCR assay showed the Expression[Expression[up-expression]-expression]regulation of miR-455-5p, miR-21-3p, miR-96-5p, miR-93-5p, RP11-973H7.5, and HOXC10 expression in LSCC as well as the Expression[down-expression]regulation of miR-486-5p, LINC00657, CTC-297N7.9, hsa_circ_0008832, hsa_circ_0033988, hsa_circ_0001445, hsa_circ_0007013, KRT4, HOPX, TGFBR2, and KDR expression in LSCC (Fig. 8). No 30128795 NORAD LncRNA Homo sapiens Kidney Neoplasms renal cancer tissues and cell lines regulation[miR-144-3p/MYCN axis] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay The results manifested that NORAD and MYCN were upregulated, while miR-144-3p was downregulated in renal cancer tissues. Moreover, NORAD/miR-144-3p/MYCN axis was found to be responsible for stimulating the malignant development of renal cancer. No 33155199 NORAD LncRNA Homo sapiens Sjogren's Syndrome blood Expression[differently-expression] qRT-PCR//Microarray "The identified 199 lncRNAs were then analysed, retaining only those transcripts for which experimentally validated microRNA (miRNA) targets had already been annotated in starBase and, among these, only lncRNAs that targeted at least 10 miRNAs were selected. Using this approach, we obtained 6 lncRNAs, including CTD-2020K17.1, LINC00657, RP11-169K16.9, LINC00511, RP11-372K14.2 and RP11-214O1.2. (Table 2)" No 31480511 NORAD LncRNA Homo sapiens Coronary Disease CHD patients Expression(highly expressed) qRT-PCR//ELISA Lnc-NORAD was highest in CHD patients, followed by DCs, and lowest in HCs (p < 0.001). In CHD patients, lnc-NORAD was positively linked with Gensini score (p = 0.001). Meanwhile, lnc-NORAD was positively linked to C-reactive protein (p = 0.023), tumor necrosis factor-alpha (p = 0.016), interleukin (IL)-6 (p = 0.003), IL-8 (P = 0.018), and IL-17A (p = 0.029). No 36319574 NORAD LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 NORAD LncRNA Homo sapiens Sars-Cov-2 Vaccination Breakthrough Infections 57 VBT and unvaccinated COVID-19 patients Expression(highly expressed) RNA-seq//Bioinformatics Analysis Further, out of the 12 lncRNA genes, 7 lncRNAs are reported to modulate immune/inflammatory responses in infectious diseases. Out of the 7 lncRNAs, LUCAT1, MALAT1, NEAT1 and GAS5 were downregulated in the VBT. LUCAT1 is a negative regulator of interferon response, and downregulation of LUCAT1 suggests an activated interferon response (30). MALAT1 is known to negatively regulate the immune response and positively regulate the inflammatory response in the infected individuals, therefore downregulation of MALAT1 in the breakthrough infection suggests an upregulated immune response and downregulated inflammatory response (31, 32). NEAT1 and GAS5 also act as pro-inflammatory lncRNAs, and their downregulation is an indicator of decreased inflammatory response in the VBT (33, 34). Amongst the upregulated lncRNAs, ROR1-AS1, UGDH-AS1 and LINC00273 were upregulated in the VBT. The upregulation of ROR1-AS1 and LINC00273 indicates a heightened immune response, whereas upregulation of UGDH-AS1 suggests a decreased disease severity possibly modulated by MOV10 and EDN1 (8). No 36466827 NOP53-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 NONRATT031178.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[highly expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT030230.2 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[lower expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 NONRATT029734.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[lower expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT029573.2 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[lower expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 NONRATT028171.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[lower expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT026300.2 LncRNA Rattus norvegicus Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension Rat Models Regulation In Vivo Experiment//qRT-PCR//Transfection//Flow Cytometry Further, the expression levels of lncRNAs (NONRATT018084.2, NONRATT009275.2, NONRATT007865.2, and NONRATT026300.2) and mRNAs (LGALS3, PDGFC, SERPINA1, and NFIL3) were confirmed using quantitative real-time PCR. In the end, lncRNA NONRATT009275.2 could facilitate macrophage polarization to M2 type and be involved in inflammatory immune response. No 34267668 NONRATT026294.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[lower expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT025413.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[highly expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT023839.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[lower expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT023574.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[highly expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT022710.2 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[lower expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 NONRATT022004.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[highly expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT020147.2 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[highly expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 NONRATT018084.2 LncRNA Rattus norvegicus Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension Rat Models Regulation In Vivo Experiment//qRT-PCR//Transfection//Flow Cytometry Further, the expression levels of lncRNAs (NONRATT018084.2, NONRATT009275.2, NONRATT007865.2, and NONRATT026300.2) and mRNAs (LGALS3, PDGFC, SERPINA1, and NFIL3) were confirmed using quantitative real-time PCR. In the end, lncRNA NONRATT009275.2 could facilitate macrophage polarization to M2 type and be involved in inflammatory immune response. No 34267668 NONRATT017365.2 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[highly expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 NPSR1-AS1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 NPSR1-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung TCGA(LUAD cancer and normal samples) Regulation Survival Analysis Herein, we identified an eight-lncRNA signature (PR-lncRNA signature, NPSR1-AS1, SATB2-AS1, LINC01090, FGF12-AS2, AC005256.1, MAFA-AS1, BFSP2-AS1, and CPC5-AS1), which contributes to predicting LUAD patient's prognosis risk and survival outcomes. Of them, NPSR1-AS1, SATB2-AS1, FGF12-AS2, and AC005256.1 could be acted as the poor prognosis markers, while LINC01090, MAFA-AS1, BFSP2-AS1, and CPC5-AS1 were treated as the protective factors for survival in LUAD patients. No 34550610 NUTM2A-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR//Microarray The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated). No 32020063 NPSR1-AS1 LncRNA Homo sapiens Colorectal Neoplasms The paired tumor and adjacent normal samples from thirty colorectal cancer patients Expression [highly expressed] Bioinformatics Analysis Then, we validated the overexpression of two first-ranked lncRNAs, i.e., NPSR1-AS1 and TLX1NB, in our in-house colorectal cancer samples as compared to the paired adjacent normal tissues. No 34406628 NUP62CL LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 NUP62-213 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 NUP62-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 NUMB-226 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 NUDCP1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 882 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 NTT LncRNA Homo sapiens Fatigue Syndrome, Chronic peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR LncRNAs NTT, MIAT and EmX2OS levels were found to be significantly elevated in ME/CFS patients as compared with healthy controls. No 30119681 NTRK2 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 NTM-IT LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1028 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 NT5C3B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NSUN2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NSA2-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 NRSN2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 NRON LncRNA Homo sapiens Sjogren's Syndrome LSGs Interaction(NFATc1/PIM-1) ISH//IHC//IF The NRON expression in the nuclei of cell-infiltration lesions of the SS patients were prominent. The NFATc1 expression was strong in the cytoplasm of infiltrating mononuclear cells and weak in ducts of both SS and controls. In SS, the NFATc1-positive area/infiltrating cell area was positively correlated with the infiltrating cell area and focus score. CD3/CD4 was expressed in infiltrating mononuclear cells, and PIM-1 colocalized with NFATc1 in the cytoplasm. These results suggest NRON along with NFATc1/PIM-1 in SS LSGs might participate in SS pathophysiology. No 34261974 NRIR LncRNA Homo sapiens Colorectal Neoplasms Exosomal Expression(highly expressed) qRT-PCR Exosomal FOXD2-AS1, NRIR, and XLOC_009459 (TCONS_00020073) levels were significantly upregulated in 203 CRC patients and 80 early-stage CRC patients compared to 201 healthy donors, possessing the area under the curve (AUC) of 0.728, 0.660, and 0.682 for CRC, as well as 0.743, 0.660, and 0.689 for early-stage CRC, respectively. No 33777763 NRIR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 NRIR LncRNA Homo sapiens Sjogren's Syndrome blood Expression[highly expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 NRCP LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 NRAV LncRNA Homo sapiens Endometrial Neoplasms 301 UCEC patients Regulation Bioinformatics Analysis We detected a novel lncRNA-focus expression signature (LFES) consisting of 11 lncRNAs that were associated with survival based on risk scoring strategy in UCEC. The risk score based on the LFES was able to separate patients of discovery cohort into high-risk and low-risk groups with significantly different overall survival and progression-free survival, and has been successfully confirmed in the validation cohort. No 29304762 NRAV LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 NRADDP LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 NR2F2-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC patients Expression[highly expressed] qRT-PCR//Western Blot Our data showed that NR2F2-AS1 was upregulated in CRC and CRC patients with high levels of NR2F2-AS1 showed a low overall survival rate. Our data showed that NR2F2-AS1 was upregulated in CRC and CRC patients with high levels of NR2F2-AS1 showed a low overall survival rate. No 32210626 NR2F2-AS1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 656 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 NR2F2-AS1 LncRNA Homo sapiens Carcinoma, Renal Cell cancer tissues Expression[highly expressed] qRT-PCR NR2F2-AS1 was upregulated in ccRCC, and high NR2F2-AS1 expression levels in ccRCC tissues were associated with poor survival. NR2F2-AS1 was upregulated in ccRCC, and high NR2F2-AS1 expression levels in ccRCC tissues were associated with poor survival. No 32109138 NR2F1-AS1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 920 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 NR_029394 LncRNA Homo sapiens Adrenocortical Carcinoma ACC tissues Expression[lower expressed] qRT-PCR//Microarray In these samples, 874 lncRNAs were differentially expressed in ACC compared with NAC, of which 409 were upregulated, and 465 were downregulated. The 874 differentially expressed lncRNAs corresponded to 330 annotated lncRNA genes. Among the upregulated lncRNAs, the greatest log2 fold change was 8.5 for an unannotated lncRNA gene, and RAD50 was the geratest upregulated, annotated lncRNA gene with a log2 fold change of 6.1. Among the downregulated lncRNAs, the greatest log2 fold change was 8.3 for an unannotated lncRNA gene and 6.4 for HAND2, the greatest downregulated annotated lncRNA gene; of these, 183 differently expressed lncRNAs had established functions in cancer development and cancer progression. Selected carcinogenesis-related lncRNAs are summarized in Table 2. No 31522749 NR_027324 LncRNA Homo sapiens Cerebral Hemorrhage brain tissues Expression[highly expressed] qRT-PCR//Microarray NR_027324, or H19, was the most upregulated lncRNA after 1 day from the two ICH models and its elevation persisted until the 7th day. No 31557399 NR_024015 LncRNA Homo sapiens Sepsis outhern Chinese Child Population Interaction(rs8506 ) Genotyping Overall, a significant association was found between rs8506 polymorphism and the risk of sepsis disease (TT vs. CC/CT: adjusted OR = 1.751, 95%CI = 1.024-2.993, P = 0.0406). In the stratified analysis, the results suggested that the carriers of TT genotypes had a significantly increased sepsis risk among the children aged 12-60 months, females, early-stage sepsis and survivors (TT vs. CC/CT: ORage = 2.413; ORfemale = 2.868; ORsepsis = 2.533; ORsurvivor = 1.822; adjusted for age and gender, P < 0.05, respectively). No 35910890 NPY6R LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[lower expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 19 No 32547537 NPSR1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RHEBP3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 935 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RHOBTB1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RHOBTB2 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 SMARCA2 LncRNA Homo sapiens Carcinoma, Hepatocellular serum Expression(highly expressed) qRT-PCR The serum levels of HOTAIR, BRM and ICR were significantly higher in HCC patients compared to LC patients and healthy subjects. The HOTAIR level was positively correlated to tumour-node metastasis (TNM), Barcelona Clinic Liver Cancer (BCLC) stage, extrahepatic metastasis, vascular invasion, portal vein tumour thrombus (PVTT), and tumour size. No 36224021 SMAD4 LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-28A) Expression[lower expressed] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD22 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 SLX1B-SULT1A4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SLX1A-SULT1A3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SLK-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 SLEAR LncRNA Homo sapiens Lupus Erythematosus, Systemic Mutation[rs13259960 ] Genotyping These findings suggest a mechanism by which the risk variant at rs13259960 modulates SLEAR expression and confers a predisposition to SLE. Taken together, these results may give insights into the etiology of SLE. No 31930717 SLCO4A1-AS1-202 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[highly expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 4. No 31619123 SLCO4A1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SLCO4A1-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[EGFR/MAPK pathway] CCK8//qRT-PCR//Wound Healing Assay//Western Blot We then collected CRC tissue samples and verified that SLCO4A1-AS1 is highly expressed in CRC tissues.Furthermore, SLCO4A1-AS1 was also upregulated in the CRC cell line.Results of western blotting assays show that its mechanism may relate to the epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK) pathway. No 31853225 SLCO4A1-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck TCGA Regulation qRT-PCR Then, we recognized a set of six FElncRNAs PFLS (SLCO4A1-AS1, C1RL-AS1, PCED1B-AS1, HOXB-AS3, MIR9-3HG, and SFTA1P) for predicting patients' prognostic risks and survival outcomes. Notably, the low-risk group of the PFLS showed a higher MHC score and cytolytic activity (CYT) score than the high-risk group, implying the low-risk group may have greater tumor surveillance and killing ability.  No 34976018 SLC9A8 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SLC9A1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SLC8A1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SLC7A7 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SLC7A11-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SLC6A6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 Slc40a1 LncRNA Mus musculus Diabetes Mellitus, Type 1 hippocampus Regulation(Ferroptosis) qRT-PCR//ELISA//Western Blot Consequently, we found that the ALFF values, as well as the T2 relaxation time of the bilateral hippocampus, were reduced in Type 1 diabetic rats. We detected Fe2+ level and lipid peroxidation products (malondialdehyde (MDA) and 4-Hydroxynonenal (4-HNE)) in the hippocampus. Mitochondria and neuron injury in the STZ-induced diabetic rats were determined using a Transmission Electron Microscope and Nissl body staining. Iron overload and ferroptosis were detected in the hippocampus. Furthermore, mRNA microarray analysis revealed 201 dysregulated mRNAs in STZ-induced type 1 diabetes (T1D). Pathway enrichment analyses indicated that differentially expressed mRNAs associated-coding genes were associated with ferroptosis. Among ferroptosis signaling pathway genes, Slc40a1 gene (ferroportin) was downregulated. We show that ferroptosis is associated with diabetic cognitive dysfunction and Slc40a1 mediates ferroptosis in T1D. No 33727075 SLC3A2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SLC39A13 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SLC38A4-AS1 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[lower expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 SLC38A2-213 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 SLC38A10 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 SLC37A4-221 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SLC35A5-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SLC26A4 LncRNA Homo sapiens Breast Neoplasms patients with breast cancer Expression(lower expressed) Bioinformatics Analysis Low SLC26A4-AS1 expression in BC was associated with age (P<0.001), estrogen-receptor status (P<0.001), PAM50 (P<0.001), and menopause status (P<0.001). Low SLC26A4-AS1 expression predicted a poorer overall survival (OS) (hazard ratio [HR]: 0.56; 95% confidence interval [CI]: 0.40-0.78; P=0.001) and disease-specific survival (DSS) (HR: 0.57; 95% CI: 0.37-0.88; P=0.011). No 34880202 SLC25A5P8 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)38) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 SLC25A51 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SLC25A44 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SLC25A39-215 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 SLC25A39-206 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 SMAD5‐AS1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)63) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 SMARCA5 CircRNA Homo sapiens Urinary Bladder Neoplasms tumor tissues Interaction(miR-432) PCR Circ-SMARCA5 was upregulated but miR-432 was downregulated in tumor tissues compared with adjacent tissues; meanwhile, circ-SMARCA5 expression was negatively correlated with miR-432 in bladder cancer tissues. Circ-SMARCA5 high expression but miR-432 low expression is correlated with advanced tumor features and poor survival of bladder cancer patients, which present as potential prognostic markers in bladder cancer. Circ-SMARCA5 high expression was correlated with larger tumor size, higher tumor stage, and lymph node (LYN) metastasis. However, miR-432 high expression was correlated with single multiplicity, smaller tumor size, lower tumor stage, less LYN metastasis in bladder cancer patients.Regarding survival, circ-SMARCA5 high expression was correlated with shorter disease-free survival (DFS) and overall survival (OS); whereas, miR-432 high expression was correlated with longer DFS and OS in bladder cancer patients. No 34482767 SLC25A25-AS1 LncRNA Homo sapiens Prostatic Neoplasms PC tissues Expression(highly expressed) Bioinformatics Analysis SLC25A25-AS1 expression in PC was significantly increased and correlated with the T stage, clinical stage, Gleason score (GS), and dismal prognosis. SLC25A25-AS1 expression in PC was significantly increased and correlated with the T stage, clinical stage, Gleason score (GS), and dismal prognosis. SLC25A25-AS1 overexpression exhibited good performance in evaluating the prognosis of PC patients. The area under the curves (AUCs) of the 1-, 3-, and 5-year overall survival (OS) for SLC25A25-AS1 was 1, 0.876, and 0.749. Moreover, the AUCs for the 1-, 3-, and 5-year progress free interval (PFI) for SLC25A25-AS1 were 0.731, 0.701, and 0.718. No 36338724 SMARCA5 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tumor tissues Expression[lower expressed] qRT-PCR Circ-SMARCA5 expression was decreased in tumor tissues compared to adjacent tissues. Moreover, circ-SMARCA5 expression negatively correlated with tumor size, lymph node metastasis, and TNM stage, but positively correlated with DFS and OS. No 31944395 SNHG1 LncRNA Homo sapiens Urinary Bladder Neoplasms Bladder Cancer cell Interaction(microRNA-9-3p/MDM2 ) qRT-PCR//RIP SNHG1 could act as a competitive endogenous RNA and decrease the expression of murine double minute 2 (MDM2) by sponging microRNA-9-3p. Furthermore, MDM2 induced ubiquitination and degradation of PPARγ that contributed to the development of bladder cancer. No 36230661 SNHG1 LncRNA Homo sapiens colorectal adenocarcinoma tumor tissues Expression[highly expressed] qRT-PCR Our findings demonstrated that that SNHG1 is potentially overexpressed in tumor tissues compared with adjacent normal tissues. No 32334448 SNHG1 LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis A total of 10 studies including 1129 patients were finally enrolled in the meta-analysis based on the inclusion and exclusion criteria. Increased SNHG1 expression was significantly associated with lymph node metastasis (OR = 3.28, 95% CI = 2.02-5.33) and advanced TNM stage (OR = 0.26, 95% CI = 0.16-0.43). Moreover, high expression of SNHG1 could predict poor overall survival (HR = 2.32, 95% CI = 1.90-2.83), event-free survival (HR = 1.58, 95% CI = 1.06-2.35), recurrence-free survival (HR = 2.15, 95% CI = 1.23-3.77), progression-free survival (HR = 2.75, 95% CI = 1.70-4.46), and disease-free survival (HR = 1.93, 95% CI = 1.10-3.40) in patients with cancer. No 31008944 SNHG1 LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis Twenty-three related studies consisting of 1389 cancer patients were enrolled in the current meta-analysis. Elevated SNHG12 expression was found to be significantly associated with poor overall survival (OS) (HR = 1.81; 95% CI: 1.53-2.13; P < 0.001) and disease-free survival (DFS) (HR = 1.40; 95% CI: 1.12-1.76; P = 0.004) in multiple cancers, which were also verified by the results of bioinformatics analysis. Moreover, overexpression of SNHG12 was also related to clinicopathological characteristics including LNM, distant metastasis, high clinical stage, large tumor size, and poor tumor differentiation in diverse types of cancers. No 33294456 SNHG1 LncRNA Homo sapiens Leukemia, Myeloid, Acute Bone marrow Expression[highly expressed] qRT-PCR lnc-SNHG1 expression in pediatric AML patients was higher than that in contros (P＜0.001). In addition, pediatric AML patients with high expression of lnc-SNHG1 had shorter EFS time (P＜0.001) and OS time (P＜0.001), further multivariate logistic regression analysis showed that lnc-SNHG1 high expression was independent factors for predicting worse EFS (P=0.001) and OS (P=0.015) in pediatric AML patients. No 32798387 SNHG1 LncRNA Homo sapiens Leukemia, Myeloid, Acute plasma exosomal Expression(highly expressed) qRT-PCR Subsequently, the downregulated plasma exosomal lncRNAs (LINC00265, LINC00467, and UCA1) and the upregulated plasma exosomal lncRNA (SNHG1) were identified in AML patients (n=65) compared to HD (n=20). No 36276083 SNHG1 LncRNA Homo sapiens Glioma cell lines Interaction[MATR3] RIP In this study, we identified 283, 31, and 164 SNHG1-interacting proteins in SK-N-BE(2)C, SK-N-DZ, and SK-N-AS neuroblastoma cells, respectively, using a RNA-protein pull-down assay coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Twenty-four SNHG1-interacting RBPs were identified in common from these three neuroblastoma cell lines. RBPs MATR3, YBX1, and HNRNPL have the binding sites for SNHG1 predicted by DeepBind motif analysis. Furthermore, the direct binding of MATR3 with SNHG1 was validated by Western blot and confirmed by RNA immunoprecipitation assay (RIP). Coexpression analysis revealed that the expression of SNHG1 is positively correlated with MATR3 ( P = 3.402 × 10-13). The high expression of MATR3 is associated with poor event-free survival ( P = 0.00711) and overall survival ( P = 0.00064). Biological functions such as ribonucleoprotein complex biogenesis, RNA processing, and RNA splicing are significantly enriched and in common between SNHG1 and MATR3. In conclusion, we identified MATR3 as binding to SNHG1 and the interaction might be involved in splicing events that enhance neuroblastoma progression. No 30516047 SNHG1 LncRNA Homo sapiens Glioma glioma tissues Interaction[SNHG1- microRNA-154-5p/miR-376b-3p- FOXP2- KDM5B feedback loop] RNA Pull-Down//ChIP//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//IHC//Transwell Assay The qRT-PCR results showed that the expression of SNHG1 in glioma tissues was higher than that in normal brain tissues, and the expression level was positively correlated with the pathological grade of glioma (P? 14 years). Moreover, the absence of IGF2BP3 rs10488282 variant and the presence of rs199653 or rs35875486 variant were significantly associated with a worse survival in EWS patients with localized disease at diagnosis. No 36338681 SLC16A1-AS1-211 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SLC15A3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SLC12A5-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR//Microarray Interestingly, we found several lncRNAs binding to Hes1 (such as, GNAS-AS1, RP11-89K10.1, and RP11-465L10.10) were up-regulated in CRC tissues showed by the tissue microarray. No 31700895 SLAMF7-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 SLAMF1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 SKAP1-AS2-202 LncRNA Homo sapiens Myasthenia Gravis Expression(highly expressed) qRT-PCR//RNA-seq We identified 378 significantly upregulated and 348 significantly downregulated lncRNAs in MG patients compared with HC. The top 5 lncRNAs (NR_104677.1, ENST00000583253.1, NR_046098.1, NR_022008.1, and ENST00000581362.1) were validated and shown to be significantly increased in the serum exosome of MG, and the expression level of NR_046098.1 significantly increased with the MG grading. No 33543801 SIGLEC7 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SHE LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SHANK2-AS3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SHANK2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SHANK2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SH3YL1-213 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SH3PXD2A-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SH3BP5-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SGO1-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[lower expressed] qRT-PCR Expression of SGO1-AS1 was considerably decreased in tumoral tissues compared with ANCTs (expression ratio = 0.49, P value = 0.03). Transcript quantities of SGO1-AS1 were associated with age at disease onset (P= 0.01). Expression of either gene was associated with hormone receptors status or clinical features such as grade and stage. No 31156154 SGMS1-AS1 LncRNA Homo sapiens Sars-Cov-2 Vaccination Breakthrough Infections 57 VBT and unvaccinated COVID-19 patients Expression(highly expressed) RNA-seq//Bioinformatics Analysis Further, out of the 12 lncRNA genes, 7 lncRNAs are reported to modulate immune/inflammatory responses in infectious diseases. Out of the 7 lncRNAs, LUCAT1, MALAT1, NEAT1 and GAS5 were downregulated in the VBT. LUCAT1 is a negative regulator of interferon response, and downregulation of LUCAT1 suggests an activated interferon response (30). MALAT1 is known to negatively regulate the immune response and positively regulate the inflammatory response in the infected individuals, therefore downregulation of MALAT1 in the breakthrough infection suggests an upregulated immune response and downregulated inflammatory response (31, 32). NEAT1 and GAS5 also act as pro-inflammatory lncRNAs, and their downregulation is an indicator of decreased inflammatory response in the VBT (33, 34). Amongst the upregulated lncRNAs, ROR1-AS1, UGDH-AS1 and LINC00273 were upregulated in the VBT. The upregulation of ROR1-AS1 and LINC00273 indicates a heightened immune response, whereas upregulation of UGDH-AS1 suggests a decreased disease severity possibly modulated by MOV10 and EDN1 (8). No 36466827 SFXN5-222 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SFTA3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NT tissue Expression[lower expressed] qRT-PCR NANCI and NKX2-1 expression in embryonic and NSCLC samples were downregulated in comparison to adult NT tissue. Patients with low expression of NANCI had shorter disease-free survival (DFS) and overall survival (OS) than those with high levels (47.6 vs 69.3 months, P=0.032 and 57.7 vs 77.6 months, P=0.021, respectively). When the expression levels of NANCI and NKX2-1 were evaluated in combination, four groups were identified (high NANCI/high NKX2-1, low NANCI/high NKX2-1, high NANCI/low NKX2-1 and low NANCI/low NKX2-1) with differential impact on DFS (P=0.042) and OS (P=0.024). No 32178834 SFTA1P LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck TCGA Regulation qRT-PCR Then, we recognized a set of six FElncRNAs PFLS (SLCO4A1-AS1, C1RL-AS1, PCED1B-AS1, HOXB-AS3, MIR9-3HG, and SFTA1P) for predicting patients' prognostic risks and survival outcomes. Notably, the low-risk group of the PFLS showed a higher MHC score and cytolytic activity (CYT) score than the high-risk group, implying the low-risk group may have greater tumor surveillance and killing ability.  No 34976018 SFPQ LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SF3B2-216 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 SF3B2-204 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 SERPINF2 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 SERPINB1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SERHL-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SEPT5-GP1BB LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SENP3-EIF4A1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and exosomes Expression[lower expressed] CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Results showed that SENP3-EIF4A1 was significantly reduced in HCC tissues and exosomes from the plasma of patients with HCC (P<0.05) and was primarily encapsulated by exosomes. No 32602848 SENP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SENCR LncRNA Homo sapiens Breast Neoplasms 110 patients and 93 controls Mutation(rs12420823) Bioinformatics Analysis Furthermore, the predictive nomogram confirmed the high weight for SENCR rs12420823*T/T and C/T genotypes in predicting recurrence within the first year. The Kaplan-Meier survival curve demonstrated low disease-free survival (T/T: 12.5 ± 1.16 months and C/T: 15.9 ± 0.86 months versus C/C: 22.3 ± 0.61 months, p < 0.001). In conclusion, the LncRNA SENCR rs12420823*C/T may be associated with an increased risk of BC in women and could be a promising genetic variant for predicting recurrence and survival. The Kaplan-Meier survival curve demonstrated low disease-free survival (T/T: 12.5 ± 1.16 months and C/T: 15.9 ± 0.86 months versus C/C: 22.3 ± 0.61 months, p < 0.001). No 36360233 SNHG1 LncRNA Homo sapiens Carcinoma, Hepatocellular 576 HCC patients and 292 normal control cases Expression(highly expressed) qRT-PCR Further, we found significant relation between the aberrant upregulation of SNHG1 and SNHG3 in tumor grade and stage. No 35592519 SNHG1 LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[miR-15b/DCLK1/Notch1 axis] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay The expression of DCLK1, Notch1, and SNHG1 was increased in GC tissues, while the expression of miR-15b was decreased. SNHG1 enhanced the effects of DCLK1/Notch1 on the EMT process through regulating miR-15b expression. No 32423385 SBDSP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SNORA74A LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SNORA7 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORA63 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORA53 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SNORA53 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 625 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 SNORA51 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORA50C LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORA48 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORA44 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORA3A LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORA38B LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORA31 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORA19 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORA17B LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORA16B LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORA16A LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORA12 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNHG9 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues regulation[miR-21] CCK8//qRT-PCR//RNA Pull-Down By analyzing the TCGA dataset, we observed downregulation of SNHG9 in NSCLC, which was confirmed by measuring the expression levels of SNHG9 in paired NSCLC tumor tissues and non-tumor tissues from NSCLC patients involved in this study. MiR-21 was upregulated in NSCLC tumor tissues and inversely correlated with SNHG9 in cancer tissues but not in non-tumor tissues. SNHG9 might downregulate miR-21 through methylation to suppress cancer cell proliferation. No 32943928 SNHG9 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Expression[highly expressed] qRT-PCR We herein reported long non-coding RNA SNHG9 was over-expressed in NSCLC tissues and cell lines compared with normal lung tissues and cell line. No 32913519 SNHG9 LncRNA Homo sapiens Prostatic Neoplasms TCGA Expression [highly expressed] RNA-seq//Bioinformatics Analysis Increased SNHG9 expression in PCa was associated with N stage (P<0.001), Gleason score (P=0.002), primary therapy outcome (P=0.001), residual tumor (P<0.001) and prostate specific antigen (PSA) (P=0.007). High SNHG9 expression predicted a poorer progression-free survival (PFS) (P=0.002), and SNHG9 expression (HR: 1.776; 95% CI: 1.067-2.955; P=0.027) was independently correlated with PFS in PCa patients. No 33532311 SNHG8 LncRNA Homo sapiens Breast Neoplasms serum of BC patients and healthy subjects Expression [lower expressed] RNA-seq After a comprehensive comparison of the BC patients and healthy subjects, we discovered five up-regulated exo-lncRNAs and six down-regulated exo-lncRNAs of interest. No 34733934 SNHG8 LncRNA Homo sapiens pancreatic adenocarcinoma pancreatic adenocarcinoma tissues Expression[highly expressed] CCK8//qRT-PCR//Flow Cytometry//Western Blot The expression of SNHG8 in pancreatic adenocarcinoma tissues was significantly higher than that of para-cancerous tissues and normal pancreatic tissues. No 30556854 SNHG8 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[lower expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 SNHG7 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR Finally, we show in clinical data that SNHG7 is overexpressed in tumors of a subset of breast cancer patients and that these patients have lower disease-free survival than patients without elevated SNHG7 expression. Finally, we show in clinical data that SNHG7 is overexpressed in tumors of a subset of breast cancer patients and that these patients have lower disease-free survival than patients without elevated SNHG7 expression. No 32444795 SNHG7 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Expression[highly expressed] qRT-PCR In this study, by qRT PCR, we concluded that the expression level of SNHG7, as a recently identified lncRNA and FAIM2 were increased in colorectal cancer tissues compared with normal adjacent tissues. No 33685194 SNHG7 LncRNA Homo sapiens Carcinoma, Hepatocellular cancer tissues Expression[highly expressed] qRT-PCR Expression of lncRNA-SNHG7 was much higher in cancer tissues than that in para-cancer tissues. The lncRNA-SNHG7 expression was correlated with tumor number, lymph node metastasis and clinical stage (P<0.05). In addition, HCC patients with higher lncRNA-SNHG7 expression had significantly poorer progression-free survival time and overall survival time (P<0.001). No 32382340 SNHG7 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression[highly expressed] qRT-PCR Compared with paired adjacent normal prostatic tissues, SNHG7 expression was increased in prostate cancer tissues (P < .001). Increased SNHG7 expression correlated with Gleason score (P = .021), bone metastasis (P = .013), pelvic lymph node metastasis (P = .008), and TNM stage (P = .007). Multivariate Cox regression analyses revealed increased SNHG7 expression was independently associated with a poor prognosis of prostate cancer patients (hazard ratio [HR] = 2.839, 95% confidence interval [CI] = 1.921-8.382, P = .038). No 32049793 SNHG7 LncRNA Homo sapiens Liver Neoplasms HCC tissues,cell lines regulation[miR-34a/SIRT1 axis] qRT-PCR//FISH SNHG7 expression was upregulated in HCC tissues and liver cancer cells compared with normal tissues and normal liver cell lines.In summary, the present study indicated that the SNHG7/miR-34a/SIRT1 axis contributed to NLRP3-dependent pyroptosis during liver cancer. No 32566017 SNHG7 LncRNA Homo sapiens Colonic Neoplasms COAD tissues Expression(highly expressed) Bioinformatics Analysis SNHG7 was found to be highly expressed in 17 types of cancer, including COAD. SNHG7 expression was found to be a potentially valuable indicator for COAD diagnosis and prognosis. No 35747807 SNORA73B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SNORA79 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNHG6 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR The expression of SNHG6 in CRC was found to be higher than that of normal tissues and was positively correlated with a poor prognosis (p < 0.05). No 32296635 SNORA9 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNX2-202 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 SNRPGP3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 831 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 SNRPC LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SNORD89 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORD83B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SNORD81 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORD76 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORD58A LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORD52 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 SNORD3A LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 SNORD36 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORD30 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 SNORD29 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORD28 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORD1C LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORD17 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SNORD16 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORD14D-201 LncRNA Homo sapiens Brain Injuries, Traumatic Brain tissues Expression[highly expressed] qRT-PCR//Microarray LncRNA and mRNA expression profiles were detected in three TBI and three control groups. Volcano plot filtering identified 99 differentially expressed lncRNAs (P < 0.05, fold change > 1.2) (Figure ​1A1A and ​andB).B). Among them, 43 lncRNAs were up-regulated and 56 lncRNAs were down-regulated. In the TBI group, n333955, n332943, n335470, ENST00000384390, and n341115 were the five most significantly up-regulated lncRNAs. While, TCONS_00018733-XLOC_008489, OTTHUMT00000076953, NR_029967, ENST00000433249, and n381234 were the five most significantly down-regulated lncRNAs (Table 3). Next, we compared mRNA expression profiles of the TBI group with the control group. No 30632503 SNORD119 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNORD116-7 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SNORD116-5 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SNORD116-13 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SNORD115-6 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[highly expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 SNORD115-42 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[highly expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 SNORD115-38 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma plasma exosome Expression[highly expressed] qRT-PCR//RNA-seq Expression levels of the lncRNAs NR_039819, NR_036133, NR_003353, ENST00000442416.1, and ENST00000416100.3 were significantly higher in exosomes from ESCC patients than non-cancer controls. No 32597791 SNORD115-38 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[highly expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 SNORD115-32 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[highly expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 SNORD115-22 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[highly expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 SNORD114-3 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 SNHG7 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 SNHG6 LncRNA Homo sapiens Colorectal Neoplasms CRC samples Expression(highly expressed) In Vivo Experiment//qRT-PCR Microarray analysis revealed that lncRNAs SNHG6, MIR4435-2HG, and TRPM2-AS1 were upregulated in CRC.These results were validated in colon cell lines. Moreover, qRT-PCR showed that the expression levels of SNHG6 and TRPM2-AS1 were upregulated in the colorectal tumor tissues compared with their paired tissues. Nonetheless, there was no significant increase in MIR4435-2HG expression in CRC samples. No 34431156 SNHG10 LncRNA Homo sapiens Osteosarcoma OS tissues regulation[ miR-218 ] CCK8//qRT-PCR " SNHG10 was upregulated in OS, while miR-218 was downregulated in OS. SNHG10 increases the methylation of miR-218 gene to promote glucose uptake and cell proliferation in OS. " No 32843060 SNHG17 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[highly expressed] qRT-PCR We showed that SNHG17 was significantly up-regulated in GC tissues compared with adjacent normal gastric tissues (p<0.01) and higher expression of SNHG17 was observed in advanced GC tissues. The results by analyzing the clinicopathological features showed that overexpression of SNHG17 expression was associated with advanced TNM stage (p=0.006), positively lymph node metastasis (p=0.006) and positively distant metastasis p=0.024). Moreover, clinical assays revealed that patients with high SNHG17 expression levels had a significantly shorter overall survival (OS) (p=0.0034) and progression-free survival (PFS) (p=0.0002) than those expressing lower. Finally, multivariate assays showed that SNHG17 was an independent prognostic marker for both OS and PFS of patients with GC. No 30779073 SNHG17 LncRNA Homo sapiens Ovarian Neoplasms Ovarian Cancer tissues regulation[CDK6] RNA Pull-Down//qRT-PCR//RIP//FISH//Luciferase Report Assay//ChIP We found that SNHG17 was overexpressed in OC and that the oncogenic transcription factor STAT3 was involved in promoting its expression. It could regulate expression of CDK6, an important cell-cycle regulator, by acting as a molecular sponge for miR-214-3p. No 32911343 SNHG17 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC clinical samples Interaction(miR-375/PAX6 axis) Western Blot//CCK8//qRT-PCR//BrdU//Transwell Assay SNHG17 expression in OSCC clinical samples was significantly increased and was correlated with unfavorable pathological indexes. Overexpression of SNHG17 significantly reduced the expression of miR-375 by sponging it, but enhanced the expression of PAX6. SNHG17 expression in OSCC clinical samples was significantly increased and was correlated with unfavorable pathological indexes. No 32924983 SNHG16 LncRNA Homo sapiens Osteoarthritis OA tissue interaction[sponging miR-373-3p] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay lncRNA SNHG16 was upregulated in OA tissue compared with normal joint tissue.In conclusion, lncRNA SNHG16 knockdown significantly limited the progression of OA by sponging miR‑373‑3p in vitro, which suggested that SNHG16 may serve as a potential therapeutic target for OA. No 33300061 SNHG16 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines and HCC tissues Expression[lower expressed] qRT-PCR//Luciferase Report Assay SNHG16 levels were markedly downregulated in both HCC cell lines and HCC tissues. No 30573973 SNHG16 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues interaction[MicroRNA-205,ZEB1] CCK8//qRT-PCR Chip microarray screening combined with the validation of differentially expressed candidate lncRNAs showed that the lncRNA small nucleolar RNA host gene 16 (SNHG16) had the largest fold change. In addition, SNHG16, miR-205, and ZEB1 interact in a common pathway during the development and occurrence of osteosarcoma, providing novel targets for intervention in the treatment of osteosarcoma. No 30453308 SNHG16 LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis A total of eight studies comprising 568 patients were included in the final meta-analysis according to the inclusion and exclusion criteria. In the pooled analysis, high SNHG16 expression significantly predicted worse overall survival (OS) in various cancers (HR = 1.87, 95% CI 1.54-2.26, P < 0.001), and recurrence-free survival (RFS) in bladder cancer (HR = 1.68, 95% CI 1.01-2.79, P = 0.045). A total of eight studies comprising 568 patients were included in the final meta-analysis according to the inclusion and exclusion criteria. In the pooled analysis, high SNHG16 expression significantly predicted worse overall survival (OS) in various cancers (HR = 1.87, 95% CI 1.54-2.26, P < 0.001), and recurrence-free survival (RFS) in bladder cancer (HR = 1.68, 95% CI 1.01-2.79, P = 0.045). Meanwhile, stratified analyses revealed that the survival analysis method, tumor type, sample size, and cut-off value did not alter the predictive value of SNHG16 for OS in cancer patients. In addition, compared to the low SNHG16 expression group, patients with high SNHG16 expression were more prone to worse clinicopathological features, such as larger tumor size, advanced clinical stage, lymph node metastasis (LNM) and distant metastasis (DM). Exploration of TCGA dataset further validated that the upregulated SNHG16 expression predicted unfavorable OS and disease-free survival (DFS) in cancer patients. No 31632195 SNHG16 LncRNA Homo sapiens Glioma glioma tissues Interaction[PI3K/AKT pathway] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay In the present study, we confirmed that lncRNA SNHG16 was highly expressed in glioma and may exert oncogenic function as a competing endogenous RNA (ceRNA) to regulate EGFR by sponging of miR-373-3p through activating PI3K/AKT pathway, which providing a new insight of the regulatory network of lncRNA SNHG16 in the development of glioma. No 31226483 SNHG16 LncRNA Homo sapiens Ischemic Stroke AIS patients Expression(lower expressed) qRT-PCR//ELISA LncRNA SNHG16 was declined in AIS patients compared to controls (p < 0.001). Interestingly, lncRNA SNHG16 was negatively related to tumor necrosis factor alpha (TNF-α) (p < 0.001), interleukin 6 (IL-6) (p = 0.013), and intracellular cell adhesion molecule-1 (ICAM-1) (p = 0.024), while positively correlated with interleukin 10 (IL-10) (p = 0.022) in AIS patients. Besides, lncRNA SNHG16 was inversely associated with the National Institutes of Health Stroke Scale (NIHSS) score in AIS patients (p = 0.003). During the follow-up period, in 14 (11.7%) patients occurred recurrence and 5 (4.2%) patients died. No 35441431 SNHG16 LncRNA Homo sapiens COVID-19 peripheral blood Expression(lower expressed) qRT-PCR Expression of SNHG6 was considerably lower in COVID-19 patients compared with control subjects (Ratio of mean expression (RME) = 0.22, P value = 7.04E-05) and in both female and male COVID-19 patients compared with sex-matched unaffected individuals (RME = 0.32, P value = 0.04 and RME = 0.16, P value = 0.000679683, respectively). However, its expression was similar among ICU-hospitalized and non-ICU patients. Similarly, expression of SNHG16 was lower in in COVID-19 patients compared with controls (RME = 0.20, P value = 5.94E-05) and in both female and male patients compared with sex-matched controls (RME = 0.32, P value = 0.04 and RME = 0.14, P value = 0.000496435, respectively) with no significant difference among ICU-hospitalized and non-ICU hospitalized patients. Expression of VDR was lower in COVID-19 patients compared with controls (RME = 0.42, P value = 0.04) and in male patients compared with male controls (RME = 0.27, P value = 0.02). Yet, expression of VDR was statistically similar between female subgroups and between ICU-hospitalized and non-ICU hospitalized patients. Expression levels CYP27B, Linc00511 and Linc00346 were similar among COVID-19 patients and healthy subjects or between their subgroups. Significant correlations have been detected between expression levels of VDR, CYP27B and SNHG6, SNHG16, Linc00511 and Linc00346 lncRNAs both among COVID-19 patients and among healthy controls with the most significant ones being SNHG6 and SNHG16 (r = 0.74, P value = 3.26e-17 and r = 0.81, P = 1.54e-22, respectively). No 34147082 SNHG16 LncRNA Homo sapiens Sars-Cov-2 Vaccination Breakthrough Infections 57 VBT and unvaccinated COVID-19 patients Expression(lower expressed) RNA-seq//Bioinformatics Analysis Further, out of the 12 lncRNA genes, 7 lncRNAs are reported to modulate immune/inflammatory responses in infectious diseases. Out of the 7 lncRNAs, LUCAT1, MALAT1, NEAT1 and GAS5 were downregulated in the VBT. LUCAT1 is a negative regulator of interferon response, and downregulation of LUCAT1 suggests an activated interferon response (30). MALAT1 is known to negatively regulate the immune response and positively regulate the inflammatory response in the infected individuals, therefore downregulation of MALAT1 in the breakthrough infection suggests an upregulated immune response and downregulated inflammatory response (31, 32). NEAT1 and GAS5 also act as pro-inflammatory lncRNAs, and their downregulation is an indicator of decreased inflammatory response in the VBT (33, 34). Amongst the upregulated lncRNAs, ROR1-AS1, UGDH-AS1 and LINC00273 were upregulated in the VBT. The upregulation of ROR1-AS1 and LINC00273 indicates a heightened immune response, whereas upregulation of UGDH-AS1 suggests a decreased disease severity possibly modulated by MOV10 and EDN1 (8). No 36466827 Snhg15-204 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[highly expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 9. No 30974198 SNHG15 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cells interaction[miR141/PD-L1] qRT-PCR Here, we introduced human lncRNA SNHG15 which was highly expressed in gastric cancer and cells.Our results suggested that SNHG15 improved the expression of PD-L1 by inhibiting miR-141, which in turn promoted the resistance of stomach cancer cells to the immune responses. No 32943878 SNHG15 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Blood samples from patients diagnosed with NSCLC Expression [highly expressed] qRT-PCR//Western Blot The serum exosomal lncRNA SNHG15 expression was markedly higher in NSCLC patients compared to patients with benign pulmonary lesions and normal controls. High serum exosomal lncRNA SNHG15 expression was closely associated with poor differentiation (p=0.035), positive lymph node metastasis (p=0.009) and advanced TNM stage (p<0.001). No 34551140 SNHG15 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR Compared with the paired normal mucosa, high expression levels of lnc-small-nucleolar RNA host gene 15 (SNHG15) were detected not only in primary CRC lesions but also in liver metastases lesions in the test set. Furthermore, in the expanded validation set, high expression of lnc-SNHG15 was significantly associated with lymph-node metastasis and liver metastasis (p < 0.05), and patients displaying high lncRNA-SNHG15 expression exhibited a shorter median overall survival duration than those displaying low expression (30.7 vs. 35.2 months; p = 0.003). No 30317592 SNHG15 LncRNA Homo sapiens Osteoarthritis OA cartilage tissues regulation[miR-141-3p,BCL2L13] Western Blot//Tunel//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//IHC In the present study, we observed that SNHG15 was downregulated in OA cartilage tissues and IL-1β-induced chondrocytes. Collectively, these findings reveal that SNHG15 inhibits OA progression by acting as an miR-141-3p sponge to promote BCL2L13 expression, suggesting that knockdown of SNHG15 expression in chondrocytes can be a potential therapeutic strategy to ameliorate OA progression. No 32247266 SNHG15 LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis High expression of the long noncoding RNA SNHG15 in cancer tissue samples predicts an unfavorable prognosis for cancer patients. LncRNA SNHG15 can be used as an adverse prognostic biomarker for cancer patients. No 32733556 SNHG15 LncRNA Homo sapiens Tuberculosis, Spinal spinal tuberculosis tissues Expression[highly expressed] qRT-PCR//ELISA//MTT//Western Blot The lncRNA SNHG15 expression in spinal tuberculosis tissues was significantly increased compared with that in the control group (p < 0.05). No 31696491 SNHG15 LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis Recently, accumulating evidence has suggested that the long noncoding RNA small nucleolar RNA host gene 15 (lncRNA SNHG15) was elevated in various malignancies and correlated to poor clinical outcome of patients. No 32776742 SNHG14 LncRNA Homo sapiens Ovarian Neoplasms 54 ovarian cancer samples Interaction(miR-124) Bioinformatics Analysis Real-time PCR on 54 ovarian cancer samples confirmed the high expression levels of CCAT1 and SNHG14 (logFC>1.5, p<0.05). The activating effect of CCAT1 and SNHG14 on the expression of these genes can be mediated by miR-203 and miR-124. No 35501644 SNHG14 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML bone marrow samples Expression(highly expressed) PCR Both lnRNA SNHG14 and lnRNA ANRIL showed high expression levels in AML bone marrow samples compared to non-AML subjects and were remarkably associated with lower Complete Remission (OR: 3.449, 95% CI: 1.324-8.985, p=0.011 for ANRIL and OR: 3.955, 95% CI: 1.510-10.356, p=0.005 for SNHG14), Relapse Free Survival (HR=3.504, 95%CI: 1.662-7.387, p=0.001 for ANRIL and HR=4.094, 95%CI: 1.849-9.067, p=0.001 for SNHG14) and Overall Survival (HR=3.353, 95%CI: 1.434-7.839, p=0.005 for ANRIL and HR=3.094, 95%CI: 1.277-7.494, p=0.012 for SNHG14), favouring poor prognostic significance in AML. Both lnRNA SNHG14 and lnRNA ANRIL showed high expression levels in AML bone marrow samples compared to non-AML subjects and were remarkably associated with lower Complete Remission (OR: 3.449, 95% CI: 1.324-8.985, p=0.011 for ANRIL and OR: 3.955, 95% CI: 1.510-10.356, p=0.005 for SNHG14), Relapse Free Survival (HR=3.504, 95%CI: 1.662-7.387, p=0.001 for ANRIL and HR=4.094, 95%CI: 1.849-9.067, p=0.001 for SNHG14) and Overall Survival (HR=3.353, 95%CI: 1.434-7.839, p=0.005 for ANRIL and HR=3.094, 95%CI: 1.277-7.494, p=0.012 for SNHG14), favouring poor prognostic significance in AML. No 34967554 SNHG14 LncRNA Homo sapiens Alzheimer Disease blood Expression[highly expressed] qRT-PCR Real-time quantitative reverse transcription PCR (qRT-PCR) assay revealed that PART1 was downregulated, while SNHG14 was upregulated in AD serum samples when compared to normal samples. No 33584243 Snhg14 LncRNA Mus musculus Cerebral Ischemia/Reperfusion Injury brain tissues,cell lines Interaction[miR-136-5p /ROCK1] RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//ELISA In present study, lncRNA-small nucleolar RNA host gene 14 (SNHG14) was found upregulated in middle cerebral artery occlusion/reperfusion (MCAO/R) treated brain tissues and oxygen-glucose deprivation and reoxygenation (OGD/R) treated PC-12 cells. No 30546117 SNHG12 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Expression[highly expressed] qRT-PCR The expression of SNHG12 and LINC00152 were significantly higher in PTC tissues than in adjacent normal tissues not only in gene expression omnibus database but the validated samples. More interesting, LINC00152 expression level was also significantly higher in PTC tissues than that in benign thyroid nodules. The upregulation of LINC00152 and SNHG12 was associated with the malignant progression of PTC. Receiver operating characteristic curve analysis also demonstrated that there was a good trend, which indicates that they may have certain diagnostic value. No 31773972 SNHG12 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues and cell lines regulation[SNHG12/miR-320b] Flow Cytometry//qRT-PCR//Western Blot//Transwell Assay Here, we found lncRNA small nuclear RNA host gene 12 (SNHG12) is highly expressed in pancreatic cancer tissues and cell lines through qRT-PCR, which suggested that SNHG12 possibly accelerates the progression of pancreatic cancer. Consequently, we extrapolated that SNHG12/miR-320b could be invoked as a promising early diagnostic hallmark and therapeutic strategy for pancreatic cancer. No 32432698 SNHG12 LncRNA Homo sapiens Sars-Cov-2 Vaccination Breakthrough Infections 57 VBT and unvaccinated COVID-19 patients Expression(lower expressed) RNA-seq//Bioinformatics Analysis Further, out of the 12 lncRNA genes, 7 lncRNAs are reported to modulate immune/inflammatory responses in infectious diseases. Out of the 7 lncRNAs, LUCAT1, MALAT1, NEAT1 and GAS5 were downregulated in the VBT. LUCAT1 is a negative regulator of interferon response, and downregulation of LUCAT1 suggests an activated interferon response (30). MALAT1 is known to negatively regulate the immune response and positively regulate the inflammatory response in the infected individuals, therefore downregulation of MALAT1 in the breakthrough infection suggests an upregulated immune response and downregulated inflammatory response (31, 32). NEAT1 and GAS5 also act as pro-inflammatory lncRNAs, and their downregulation is an indicator of decreased inflammatory response in the VBT (33, 34). Amongst the upregulated lncRNAs, ROR1-AS1, UGDH-AS1 and LINC00273 were upregulated in the VBT. The upregulation of ROR1-AS1 and LINC00273 indicates a heightened immune response, whereas upregulation of UGDH-AS1 suggests a decreased disease severity possibly modulated by MOV10 and EDN1 (8). No 36466827 SNHG11 LncRNA Homo sapiens Colorectal Neoplasms blood Interaction[Hippo pathway] qRT-PCR The combination of ZFAS1, SNHG11, LINC00909 and LINC00654 showed high diagnostic performance for CRC (AUC: 0.937), especially early-stage disease (AUC: 0.935). Plasma levels of the four candidate lncRNAs were significantly reduced in postoperative samples compared to preoperative samples. Mechanistically, high SNHG11 expression promotes proliferation and metastasis by targeting the Hippo pathway. No 31633800 SNHG11 LncRNA Homo sapiens Pancreatic Neoplasms blood Expression[highly expressed] qRT-PCR After selection and validation, three characteristic plasma candidate lncRNAs, ABHD11-AS1, LINC00176 and SNHG13, were identified, and their levels were significantly higher in PC patients than in normal controls. No 31333792 SNHG17 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SNHG18 LncRNA Homo sapiens Carcinoma, Hepatocellular liver tissues Expression[lower expressed] qRT-PCR Small nucleolar RNA host gene 18 was downregulated in liver tissues compared to paired adjacent noncancerous tissues ( P < .0001). No 30126319 SNHG6 LncRNA Homo sapiens Carcinoma, Renal Cell RCC tissues Expression[highly expressed] qRT-PCR SNHG6 was shown to be markedly upregulated in RCC tissues as compared with normal controls. Elevated SNHG6 was found to significantly correlate with clinical stage, lymph node metastasis, Fuhrman grade, and tumor size (p<0.05). Kaplan-Meier survival analysis exhibited that elevated SNHG6 was remarkably associated with poor overall survival (p<0.001). No 30575902 SNHG18 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SNHG6 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Interaction[binding to miR-139-5p] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay The expression level of SNHG6 in HCC samples was significantly higher than in the control group (**P = 0.0038, Figure 4a). The positive regulation between SNHG6 and SERPINH1 was demonstrated in this study. In contrast, miR-139-5p was significantly down-regulated in HCC cells, the inhibition of miR-139-5p promotes the proliferation of HCC cells, and accelerated the cell cycle of HCC cells. No 31258024 SNHG6 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues,cell lines Interaction[hsa-miR-125b/Snail1/2/NUAK1 pathway] qRT-PCR//Western Blot We showed that overexpression of SNHG6 induced epithelial-mesenchymal transition (EMT) and promoted the migration and invasion capabilities of BC cells.Mechanistically, SNHG6 induced EMT of BC cells by upregulating the expression levels of Snail1/2 and regulated BC cell migration and invasion by tumor suppressive hsa-miR-125b and its target gene NUAK Family Kinase 1 (NUAK1). Furthermore, we found that SNHG6 was positively correlated with Snail1/2 expression, and negatively correlated with hsa-miR-125b expression in BC specimens. Further study showed that SNHG6 repressed hsa-miR-125b expression to upregulate Snail1/2. Conversely, hsa-miR-125b knockdown augmented SNHG6 expression in BC cells. No 30168179 SNHG6 LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis Compared to corresponding normal tissues, SNHG6 expression was significantly up-regulated in most types of solid tumors. No 31710436 SNHG6 LncRNA Homo sapiens Prostatic Neoplasms PCa tissues Expression[highly expressed] qRT-PCR SNHG6 expression was validated in 13 PCa tissues and 9 non-tumor samples. The results indicated that SNHG6 was significantly upregulated in PCa tissues compared with that in non-tumor tissues In The Cancer Genome Atlas and Taylor datasets, high expression of SNHG6 in PCa tissues was identified to be significantly associated with shorter disease-free survival. No 30911973 SNHG6 LncRNA Homo sapiens COVID-19 peripheral blood Expression(lower expressed) qRT-PCR Expression of SNHG6 was considerably lower in COVID-19 patients compared with control subjects (Ratio of mean expression (RME) = 0.22, P value = 7.04E-05) and in both female and male COVID-19 patients compared with sex-matched unaffected individuals (RME = 0.32, P value = 0.04 and RME = 0.16, P value = 0.000679683, respectively). However, its expression was similar among ICU-hospitalized and non-ICU patients. Similarly, expression of SNHG16 was lower in in COVID-19 patients compared with controls (RME = 0.20, P value = 5.94E-05) and in both female and male patients compared with sex-matched controls (RME = 0.32, P value = 0.04 and RME = 0.14, P value = 0.000496435, respectively) with no significant difference among ICU-hospitalized and non-ICU hospitalized patients. Expression of VDR was lower in COVID-19 patients compared with controls (RME = 0.42, P value = 0.04) and in male patients compared with male controls (RME = 0.27, P value = 0.02). Yet, expression of VDR was statistically similar between female subgroups and between ICU-hospitalized and non-ICU hospitalized patients. Expression levels CYP27B, Linc00511 and Linc00346 were similar among COVID-19 patients and healthy subjects or between their subgroups. Significant correlations have been detected between expression levels of VDR, CYP27B and SNHG6, SNHG16, Linc00511 and Linc00346 lncRNAs both among COVID-19 patients and among healthy controls with the most significant ones being SNHG6 and SNHG16 (r = 0.74, P value = 3.26e-17 and r = 0.81, P = 1.54e-22, respectively). No 34147082 SNHG6 LncRNA Homo sapiens Lung Injury BPD model Interaction(miR-335/KLF5/NF-κB pathway) In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//ELISA//Bioinformatics Analysis Firstly, SNHG6 was highly expressed and miR-335 was lowly expressed in BPD model, SNHG6 knockdown and miR-335 mimics both alleviated hyperoxia-induced lung cell injury, and SNHG6 targeted miR-335. Subsequently, KLF5 was targeted by miR-335, and KLF5 promoted lung cell injury via activating NF-κB pathway. Furthermore, SNHG6 mediated lung cell injury via regulating the miR-335/KLF5/NF-κB pathway. No 35809451 SNHG5 LncRNA Homo sapiens Stomach Neoplasms GC tissues,cell lines Interaction[down-regulating miR-20a] qRT-PCR//Luciferase Report Assay//RIP//Western Blot The expression of SNHG5 was decreased in GC tissues and cell lines.Overexpressed METase promoted cell apoptosis and autophagy via up-regulating the expression of SNHG5 and down-regulating miR-20a in GC. No 30227213 SNHG5 LncRNA Homo sapiens Stomach Neoplasms 848 cases and 880 controls Polymorphisms (rs61396151, rs1059307, rs11961028, rs9351065) Bioinformatics Analysis//Genotyping Here, we designed a case-control study of 848 cases and 880 controls to investigate the associations of polymorphisms (rs61396151, rs1059307, rs11961028, rs9351065) in lncRNA SNHG5 with the risk and prognosis of GC. The results indicate rs61396151 associated with decreased risk of GC (OR = 0.78, 95% CI = 0.62-0.96), but there were no correlations observed with the clinicopathological features of GC (P > 0.05).  However, the CA genotype of rs61396151 was correlated with poor overall survival rate in a multivariate cox regression model (HR = 1.91, P = 0.040), but it was reversed with adjustment for age, gender and TNM stage (HR = 1.35, P = 0.213).  No 33865958 SNHG5 LncRNA Homo sapiens Stomach Neoplasms serum and cancer tissues Expression(lower expressed) qRT-PCR The expression of lncRNA SNHG5 in the serum of gastric cancer was down-regulated, lower than that in the benign gastrosia group and healthy group (P < 0.05). The relative expression of lncRNA SNHG5 in cancer tissues was down-regulated compared with that in adjacent tissues (P < 0.05). lncRNA SNHG5 was correlated with drinking history and TNM stage (P < 0.05). No 34150139 SNHG5 LncRNA Homo sapiens Breast Neoplasms BC cell Interaction(miR-299/BACH1 ) Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Cell Cycle Assay SNHG5 and BACH1 expressions were increased in BC cell while miR-299 level was decreased.SNHG5 increased BACH1 expression by directly targeting miR-299. However, inhibition of miR-299 or overexpression of BACH1 could reverse the inhibitory effects of sh-SNHG5 on cell proliferation and glycolysis in BC. No 34351577 SNHG5 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues and cells Interaction(RBM47/SNHG5/FOXO3 axis) CCK8//qRT-PCR//RIP//ChIP RBM47 can bind directly to and stabilized lncRNA Small Nucleolar RNA Host Gene 5 (SNHG5) to inhibit PTC cells proliferation and activate autophagy in vitro and in vivo. SNHG5 inhibits ubiquitination and degradation of FOXO3 by recruiting Ubiquitin Specific Peptidase 21 (USP21), then promotes the translocation of FOXO3 from cytoplasm to nucleus. No 35338124 SNHG5 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Expression[lower expressed] qRT-PCR The expression of SNHG5 was downregulated in the cancer genome atlas cohort. Similarly, decreased expression of SNHG5 was observed in ovarian cancer tissues. No 31884343 SNHG5 LncRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow and plasma Expression[highly expressed] qRT-PCR SNHG5 expression levels were consistently higher in the bone marrow and plasma of AML patients than those in the healthy controls (p<0.01). Furthermore, SNHG5 upregulation more frequently occurred in AML patients with advanced FAB classification (p<0.005) and unfavorable cytogenetics (p=0.001). In addition, the data of Kaplan-Meier method revealed that overall patient survival for those with high plasma SNHG5 expression was significantly shorter than those patients with low SNHG5 expression (p<0.0070). No 29917184 SNHG5 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[lower expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 SNHG5 LncRNA Homo sapiens Periodontitis human and mouse periodontal tissues Regulation(NF-κB ) Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay SNHG5 expression was down-regulated in human and mouse periodontal tissues compared to that in the healthy controls. In vitro experiments demonstrated that SNHG5 significantly ameliorated tumour necrosis factor α-induced inflammation. Mechanistically, SNHG5 directly binds to the nuclear factor-kappa B (NF-κB) p65 subunit and inhibits its translocation, thereby suppressing the NF-κB signalling pathway activation and reducing the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing three inflammasome expression. Locally injecting si-SNHG5 aggravated the periodontal destruction. No 35713268 SNHG4 LncRNA Homo sapiens Glioblastoma GBM tissues regulation[miR-138/c-Met axis ] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot In this study, we confirmed the upregulation of SNHG4 in GBM tissues collected from GBM patients. Therefore, SNHG4 regulates miR-138/c-Met axis to promote the proliferation of GBM cells. In addition, lower survival rate of GBM patients was observed in patients with high SNHG4 expression level. No 32427712 SNHG30-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 SNHG3 LncRNA Homo sapiens Breast Neoplasms clinical tissues and breast cancer cell lines Interaction( miR-1273g-3p/BMP3 axis) In Vivo Experiment//IHC//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay Dual luciferase reporter gene assay was utilized to analyze the binding sites of miR-1273g-3p on SNHG3 and BMP3. Expression of BMP3 was positively regulated by SNHG3 via exosomal miR-1273g-3p. No 35081500 SNHG3 LncRNA Homo sapiens Carcinoma, Hepatocellular 576 HCC patients and 292 normal control cases Expression(highly expressed) qRT-PCR Further, we found significant relation between the aberrant upregulation of SNHG1 and SNHG3 in tumor grade and stage. No 35592519 SNHG3 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Expression[lower expressed] qRT-PCR qPCR results indicated marked upregulation of CDKN2A-AS1, C7orf55, LINC00184, HEIH, and ZEB2 expression, whereas that of SNHG3, LINC00630, LOC100133669, APTR, LINC-PINT, and SEMA5A was downregulated in OC tissues as compared with levels in normal ovary tissues (Fig. ?(Fig.5b5b). No 31098301 SNHG3 LncRNA Homo sapiens Cholangiocarcinoma ICC tissues Expression[highly expressed] qRT-PCR//Microarray lncRNA microarray and RT-qPCR assays revealed that SNHG3 expression levels were significantly increased in ICC tissues compared to the adjacent non-tumor tissues. A high SNHG3 expression level was significantly correlated with shorter OS in ICC patients. No 31934101 SNHG3 LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis Excavation of TCGA dataset valuated that SNHG3 was upregulated in various cancers and predicted worse OS and DFS. Overexpressed SNHG3 was strongly associated with poor survival and clinical outcomes in human cancers and therefore can serve as a promising biomarker for predicting patients' prognosis. No 32802874 SNHG29 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SNHG29 LncRNA Homo sapiens Adrenocortical Carcinoma ACC tissues Expression[lower expressed] qRT-PCR//Microarray In these samples, 874 lncRNAs were differentially expressed in ACC compared with NAC, of which 409 were upregulated, and 465 were downregulated. The 874 differentially expressed lncRNAs corresponded to 330 annotated lncRNA genes. Among the upregulated lncRNAs, the greatest log2 fold change was 8.5 for an unannotated lncRNA gene, and RAD50 was the geratest upregulated, annotated lncRNA gene with a log2 fold change of 6.1. Among the downregulated lncRNAs, the greatest log2 fold change was 8.3 for an unannotated lncRNA gene and 6.4 for HAND2, the greatest downregulated annotated lncRNA gene; of these, 183 differently expressed lncRNAs had established functions in cancer development and cancer progression. Selected carcinogenesis-related lncRNAs are summarized in Table 2. No 31522749 SNHG22 LncRNA Homo sapiens ovarian carcinoma EOC tissues Expression[highly expressed] qRT-PCR Here, we found that SNHG22 was significantly increased in EOC tissues and was significantly associated with a low level of differentiation. No 31581131 SNHG20 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Interaction[SNHG20/PTEN pathway] Flow Cytometry//qRT-PCR//MTT//Western Blot SNHG20 expression level and HBx protein level were upregulated in HBV(+) group than that of HBV(-) group, whereas PTEN protein level was downregulated in HBV(+) group. Besides, SNHG20 was highly expressed in HBV(+) HCC cells than in HBV(-) HCC cells.Moreover, SNHG20 was confirmed to interact with PTEN, which negatively regulated PTEN protein level. Finally, we proved HBx-SNHG20-PTEN signalling pathway involved in the regulation of HCC cell proliferation and apoptosis. In vivo experiments showed SNHG20 knockdown inhibited tumour growth of HBV(+) HCC. HBx promoted the proliferation of HCC cell and reduced the apoptosis of HCC cells through the SNHG20/PTEN signalling pathway. No 30690477 SNHG20 LncRNA Homo sapiens Cholangiocarcinoma CCA tissues interaction[Sponging miR-520f-3p] CCK8//qRT-PCR//Luciferase Report Assay In CCA, SNHG20 was highly expressed. Overexpressed SNHG20 was markedly interrelated with the lymph node invasion and TNM stage. These data confirmed the knockdown SNHG20 expression in CCA could inhibit the proliferation by means of sponging miR-520f-3p. In CCA, SNHG20 was highly expressed. Overexpressed SNHG20 was markedly interrelated with the lymph node invasion and TNM stage. No 32907346 SNHG20 LncRNA Homo sapiens COVID-19 mild and severe COVID-19 patients Regulation Bioinformatics Analysis Interestingly we found six lncRNAs (TALAM1, DLEU2, and UICLM CASC18, SNHG20, and GNAS) involved in the protein-coding DEG-lncRNA network; which might be served as potential biomarkers for COVID-19 patients. No 34975833 SBF2-AS1 LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 SATB2-AS1-205 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[lower expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 21. No 31619123 RHPN1-AS1 LncRNA Homo sapiens Glioma glioma tissues Expression[highly expressed] qRT-PCR RHPN1-AS1 was upregulated in glioma tissues. Its level was correlated to histological grade, Karnofsky (KPS) score and postoperative recurrence of glioma patients, rather than sex, age, pathological and tumor size. Glioma patients expressing high level of RHPN1-AS1 suffered worse OS and RFS than those with low level. Advanced histological grade, KPS score <80 and high level of RHPN1-AS1 were considered to be risk factors influencing postoperative prognosis of glioma. High level of RHPN1-AS1 is an independent risk factor for poor prognosis of glioma, which may be utilized as a prognostic hallmark. No 32782561 RP11-517C16.4 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11-513G11.1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse blood Expression[highly expressed] qRT-PCR Compared with normal control group, the expression of RP11-513G11.1 significantly increased in DLBCL patients (P<0.001). The expression of RP11-513G11.1 not related with the age, sex, course of treatment and germinal center B-cell-like lymphoma(GCB) subtypes of the patients, but it related with the diameter of tumor,Ann Arbor stage,B symptoms,chemosensitivity and the international prognostic index(IPI) (P<0.05). The progression-free survival time and overall survival time of patients, whom with high expression of RP11-513G11.1 were significantly shorter than those of RP11-513G11.1 low expression（P<0.001）. The median progression-free survival time and overall survival time of chemotherapy-sensitive patients were significantly longer than those of chemotherapy-resistant patients (P<0.001). Univariate analysis and multivariate Cox regression analysis showed that Ann Arbor stage, RP11-513G11.1 expression, IPI and chemosensitivity were also the independent factors affecting the prognosis of DLBCL patients（P<0.05） No 31607306 RP11-495P10.6 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11‐481E4.1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)40) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-480C16.1 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[highly expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 RP11‐473P24.2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)103) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-471J12.1 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[lower expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 RP11-45M22.3 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11-452K12.7 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11‐442N24__B.1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)22) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11‐441O15.3 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)110) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-438N5.3 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung plasma Expression[lower expressed] qRT-PCR The results revealed that plasma level of RP11-438N5.3 was significantly lower in NSCLCs than that in HCs (p <0.01). No 32184656 RP11‐410D17.2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)92) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-401P9.4 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[lower expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 RP11‑400N13.3 LncRNA Homo sapiens Stomach Neoplasms GC tissues Regulation qRT-PCR Following RT‑qPCR validation, AC016735.2, AP001626.1, RP11‑400N13.3 and RP11‑243M5.2 were considered to be consistent with the prediction of the bioinformatics analysis. Transcriptome sequencing and RT‑qPCR experiments identified 4 lncRNAs, including AC016735.2, AP001626.1, RP11‑400N13.3 and RP11‑243M5.2 to have an important role in the carcinogenesis of GC. No 29693709 RP11-399F2.2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11-397A15.4 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Expression[highly expressed] qRT-PCR The expression levels of lncRNA RP11-397A15.4 were significantly reduced in GC tissues and cell lines. Increased expression of lncRNA RP11-397A15.4 was associated with tumor differentiation, clinical stage, and distant metastasis. Furthermore, the area under the ROC curve (AUC) was up to 0.9726 (95%CI=0.9492-0.9961, P<0.0001). The correlation between lncRNA RP11-397A15.4 expression and overall survival (OS) was statistically significant. No 30610039 RP11-379k17.4 LncRNA Homo sapiens Endometrial Neoplasms Regulation qRT-PCR//Luciferase Report Assay//Western Blot Rp11-379k17.4, a new gene related to endometrial cancer, was identified as noncoding RNA. It was a more effective ceRNA associated with the microRNA-200c-3p-noxa network. No 33758604 RP11‐377K22.2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)80) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-372K14.2 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[differently-expression] qRT-PCR//Microarray "The identified 199 lncRNAs were then analysed, retaining only those transcripts for which experimentally validated microRNA (miRNA) targets had already been annotated in starBase and, among these, only lncRNAs that targeted at least 10 miRNAs were selected. Using this approach, we obtained 6 lncRNAs, including CTD-2020K17.1, LINC00657, RP11-169K16.9, LINC00511, RP11-372K14.2 and RP11-214O1.2. (Table 2)" No 31480511 RP11-372K14.2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11‐363E6.1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)48) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-354K4.2 LncRNA Homo sapiens Stomach Neoplasms eighty-three GC tissues Expression(lower expressed) qRT-PCR The significant downregulation of LINC00365 (66.3%) and RP11-354K4.2 (62.7%) were observed in GC samples; while the upregulation of LINC01389, RP11-138J23.1, TWIST1, MMP13, MAML1, CD44s, and SALL4 were found in 67.5%, 45.8%, 56.6%, 44.6%, 59%, 55.4%, and 62.7% tumors samples at the mRNA level, respectively. No 36208698 RP11-346L1.2 LncRNA Homo sapiens Osteosarcoma osteosarcoma project Regulation Bioinformatics Analysis We developed a five-lncRNA signature as a potential prognostic indicator for osteosarcoma. The AUC for predicting 5-year survival was 0.745, which suggested good performance of the five-lncRNA signature. No 33964903 RP11-342M1.7 LncRNA Homo sapiens Leukemia, Myeloid, Acute Bone marrow Expression[highly expressed] qPCR//RNA-seq In further qPCR validation, lncRNA RP11-342M1.7 and lncRNA CDCA4P3 were upregulated, while lncRNA CES1P1, lncRNA AC008753.6 and lncRNA RP11-573G6.10 were downregulated in AML patients compared with controls. No 31356197 RP11-342L8.2 LncRNA Homo sapiens Psoriasis Ten pairs of psoriatic and normal tissues Expression(highly expressed) qRT-PCR//RNA-seq//Bioinformatics Analysis By RT-qPCR validation, lncRNAs RP11-22A3.2, RP11-342L8.2, and CTD-2006H14.2 were increased (all P < 0.001), while lncRNAs AP000442.4, CCDC144NL-AS1, and MIR663AHG were decreased (all P < 0.01) in psoriatic tissue vs. normal tissue. Interestingly, psoriatic lncRNA RP11-342L8.2 was also observed to positively correlated with psoriasis area and severity index (PASI) (r = 0.405, P = 0.045). No 35028895 RP11-326C3.12 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11‐325P15.2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)46) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11‐320M2.1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)37) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11‐316E14.2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)31) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-515E23.2 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 RP11-521D12.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11‐307C19.1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)101) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-530C5.1 LncRNA Homo sapiens Multiple Sclerosis peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Our results showed that in relapsing MS patients, compared to remitting MS patients and healthy controls, lncRNA RP11-530C5.1 was up-regulated while AL928742.12 was down-regulated. No 31576494 RP11-864N7.4 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 RP11‐82H13.2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)41) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-816J8.1 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[highly expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 RP11-783K16 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 RP11‐774O3.1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)89) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-731F5.2 LncRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR The level of RP11-731F5.2 stably present in the serum of GC patients (median [interquartile range, IQR 25-75]: 1.495 [0.912-2.367]) was significantly higher than that in healthy controls (0.620 [0.400-1.222]) (P < 0.001). No 33176259 RP1‐172N19.3 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)24) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11‐720L2.3 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)12) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-707G18.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP116-8G5.3 LncRNA Homo sapiens lung squamous cell carcinoma LUSC samples Expression[highly expressed] CCK8//Colony Formation Assay//Flow Cytometry//Western Blot Our results showed that CTD-2562J17.6 and FENDRR were significantly downregulated while MIR205HG, LNC_000378, RP11-116G8.5, RP3-523K23.2, and RP5-968D22.1 were significantly upregulated in all five LUSC samples. Importantly, MIR205HG was upregulated in LUSC clinical samples as well as in LUSC cell lines. No 32188965 RP11-679B19.1 LncRNA Homo sapiens Crohn Disease Crohn's disease cases Mutation(rs11861007 ) Genotyping We have identified a variant in WWOX and in lncRNA RP11-679B19.1 as a disease-modifying genetic variant associated with recurrent fibrostenotic CD and replicated this association in an independent cohort. No 29361163 RP11‐655M14.14 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)14) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP1-163G9.1 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[lower expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 RP11‐637I8.2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)44) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP1-162J8.3 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 RP11-626K17.3 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11‐626I20.2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)50) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11‐605F14.2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)53) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-598F7.3 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[highly expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 RP11-598F7.3 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11-573G6.10 LncRNA Homo sapiens Leukemia, Myeloid, Acute Bone marrow Expression[lower expressed] qPCR//RNA-seq In further qPCR validation, lncRNA RP11-342M1.7 and lncRNA CDCA4P3 were upregulated, while lncRNA CES1P1, lncRNA AC008753.6 and lncRNA RP11-573G6.14 were downregulated in AML patients compared with controls. No 31356197 RP11-569A11.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11‐568J23.1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)49) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-556E13.1 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[highly expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 RP11-556E13.1 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[highly expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 6 No 32547537 RP11‐555H23.1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)3) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-533E19.5 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11-531A24.5 LncRNA Homo sapiens Endometrial Neoplasms 301 UCEC patients Regulation Bioinformatics Analysis We detected a novel lncRNA-focus expression signature (LFES) consisting of 11 lncRNAs that were associated with survival based on risk scoring strategy in UCEC. The risk score based on the LFES was able to separate patients of discovery cohort into high-risk and low-risk groups with significantly different overall survival and progression-free survival, and has been successfully confirmed in the validation cohort. No 29304762 RP11-531A24.3 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[lower expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 RP11-316A16.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11‐299D14.2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)33) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-94A24.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RNU4ATAC17P LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RNU4ATAC11P LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RNU4ATAC10P LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RNU12 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RNPS1P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 819 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RNPS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RNF8-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 RNF32-DT LncRNA Homo sapiens Endometrial Neoplasms 301 UCEC patients Regulation Bioinformatics Analysis We detected a novel lncRNA-focus expression signature (LFES) consisting of 11 lncRNAs that were associated with survival based on risk scoring strategy in UCEC. The risk score based on the LFES was able to separate patients of discovery cohort into high-risk and low-risk groups with significantly different overall survival and progression-free survival, and has been successfully confirmed in the validation cohort. No 29304762 RNF217-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RNF217 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RNF216P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RNF165 LncRNA Homo sapiens Prostatic Neoplasms tumor tissue and urine regulation[LIF/LIFR Expression] qRT-PCR The lncAMPC was overexpressed in tumor tissue and urine of metastatic PCa patients and promoted PCa tumorigenesis and metastasis. Therefore, the lncAMPC/LIF/LIFR axis plays a critical role in PCa metastasis and immunosuppression and may serve as a prognostic biomarker and potential therapeutic target. No 32592689 RNF139-DT LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR//Microarray The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated). No 32020063 RNA5-8SP4-201 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 RN7SL417P LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RN7SL3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 597 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RN7SL141P LncRNA Homo sapiens Sjogren's Syndrome blood Expression[highly expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 RN7SL1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 785 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RMST LncRNA Homo sapiens Thyroid cancer, medullary medullary thyroid tumor tissues Expression [highly expressed] qRT-PCR Here we have tested three up-regulated (RMST, FTX, IPW) and one down-regulated (RMRP) lncRNAs in our samples (formalin fixed paraffin embedded tissues from twenty-one MEN2 and ten sMTC patients) by RT-qPCR analysis. No 33407723 RMRP LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung blood Expression[lower expressed] qRT-PCR Five lncRNAs (RMRP, NEAT1, TUG1, MALAT1, and H19) stably expressed in plasma. Differential expression analysis showed that RMRP and TUG1 had significantly lower expression levels in the NSCLC group than in the control group (P = 0.001, Figure 2A, Supplementary Table S2 ). In contrast, NEAT1 and MALAT1 had significantly higher expression levels in the NSCLC group than in the control group (P = 0.022 and 0.002, respectively, Figure 2A, Supplementary Table S2 ). The expression level of H19 showed no significant difference between NSCLC and control groups (P = 0.534, Figure 2A, Supplementary Table S2 ). No 33425713 RMRP LncRNA Homo sapiens Osteoarthritis cartilage tissues regulation[miR-206/CDK9 axis] Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay We found that the expression of RMRP was significantly increased in cartilage tissues of patients with OA.Taken together, our results indicated that RMRP knockdown could promote proliferation and inhibit apoptosis in OA chondrocytes via the miR-206/CDK9 axis. No 33305725 RMRP LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissue Interaction[miR-206] qRT-PCR//MTT//Transwell Assay//Western Blot We found that the lncRNA RMRP was highly expressed in bladder cancer tissue, compared with adjacent tissue. What's more, RMRP could promote the proliferation, migration and invasion of BC cell lines via regulating miR-206 as a sponge. We also found that the expression of RMRP was closely related with the size, lymph node metastasis and survival time of patients. No 30779067 RMRP LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues Regulation(demethylation) In Vivo Experiment//Western Blot//MeRIP//Migration Assay//CCK8//qRT-PCR//RIP//Cell Apoptosis Assay//Invasion Assay The results showed lncRNA RMRP expression was significantly enhanced in lung adenocarcinoma tissues, and is positively correlated with poor prognosis. . In addition, ALKBH5 upregulated RMRP expression via demethylation, and ALKBH5 knockdown inhibited the tumorigenesis of lung adenocarcinoma in vitro and vivo. The results showed lncRNA RMRP expression was significantly enhanced in lung adenocarcinoma tissues, and is positively correlated with poor prognosis. No 33934179 RMRP LncRNA Homo sapiens Arthritis, Rheumatoid blood Expression[highly expressed] qRT-PCR The results indicate that T cells of RA patients display increased levels of GAS5 (3.31-fold, p = 0.007), RMRP (2.43-fold, p = 0.02), and THRIL (2.14-fold, p = 0.03) lncRNAs compared with those of controls. No 31346885 RMRP LncRNA Homo sapiens Depressive Disorder, Major blood Expression[lower expressed] qRT-PCR Five were found to be differentially expressed in MDD patients compared to healthy subjects (Fig. 1, Supplemenatal Table 3): MER11C, PCAT1, PCAT29, RMRP, and Y5. Whereas the expression level of RMRP in MDD patients was significantly lower than in healthy subjects (p = 0.000227, U = 175), the expression levels of MER11C, PCAT1, PCAT29, and Y5 were significantly higher in MDD patients than in healthy subjects (MER11C: p = 0.0215, U = 262; PCAT1: p = 0.0183, U = 199; PCAT29: p = 0.00693, U = 165; Y5: p = 0.00665, U = 226). No 31351391 RMRP LncRNA Homo sapiens Thyroid cancer, medullary medullary thyroid tumor tissues Expression [lower expressed] qRT-PCR Here we have tested three up-regulated (RMST, FTX, IPW) and one down-regulated (RMRP) lncRNAs in our samples (formalin fixed paraffin embedded tissues from twenty-one MEN2 and ten sMTC patients) by RT-qPCR analysis. No 33407723 RMI2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RLIM LncRNA Homo sapiens Tonne-Kalscheuer syndrome embryonic stem cell model Mutation(RLIM p.(Tyr421Cys) variant) Transfection//Immunoblotting//qRT-PCR//Cell Proliferation Assay//IF We show that the RLIM p.(Tyr421Cys) variant disrupts both expression and function of the protein in an embryonic stem cell model. RLIM p.(Tyr421Cys) is correctly localised to the nucleus, but is readily degraded by the proteasome. The RLIM p.(Tyr421Cys) variant also displays significantly impaired E3 ubiquitin ligase activity, which interferes with RLIM function in Xist long-non-coding RNA induction that initiates imprinted X-chromosome inactivation. No 33953269 Risa LncRNA Mus musculus Diabetic Nephropathies DN mice and MPCs Regulation(Sirt1/GSK3β axis) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay Risa and activated GSK3β were overexpressed, but Sirt1 was downregulated in DN mice and high glucose-treated MPCs (P < 0.001, db/m vs. db/db, NG or HM vs. HG), which was correlated with poor prognosis. Risa overexpression attenuated Sirt1-mediated downstream autophagy levels and aggravated podocyte injury by inhibiting the expression of Sirt1 (P < 0.001, db/m vs. db/db, NG or HM vs. HG). . In contrast, Risa suppression enhanced Sirt1-induced autophagy and attenuated podocyte injury, which could be abrogated by EX-527 (P < 0.001, db/db + Risa-AAV vs. db/db, HG + Risa-LV vs. HG). Risa and activated GSK3β were overexpressed, but Sirt1 was downregulated in DN mice and high glucose-treated MPCs (P < 0.001, db/m vs. db/db, NG or HM vs. HG), which was correlated with poor prognosis. No 35614465 RIF1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 RNU4ATAC15P LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RNU4ATAC5P LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11‐296I10.3 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)62) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RNU4ATAC6P LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11-295G20.2 LncRNA Homo sapiens Carcinoma, Hepatocellular liver cancer cells Interaction(RP11-295G20.2/PTEN axis) qRT-PCR Here, lncRNA RP11-295G20.2 is found to be significantly upregulated in hepatocellular carcinoma (HCC) and promotes the growth of liver cancer cells both in vitro and in vivo. Furthermore, RP11-295G20.2 inhibits autophagy in liver cancer cells. Interestingly, RP11-295G20.2 directly binds to the PTEN protein and leads to its degradation. RP11-295G20.2 expression is inversely correlated with PTEN protein expression in 82 TCGA/TCPA-LIHC samples. Surprisingly, RP11-295G20.2-induced PTEN degradation occurs through the lysosomal pathway instead of the proteasome pathway. RP11-295G20.2 binds to the N terminus of PTEN and facilitates the interaction of p62 with PTEN. Thus, PTEN is translocated into lysosomes and degraded. RP11-295G20.2 also influences AKT phosphorylation and forkhead box O 3a (FOXO3a) translocation into the nucleus, in turn regulating the transcription of autophagy-related genes. Collectively, RP11-295G20.2 directly binds to PTEN and enables its lysosomal degradation.  No 34903728 RP11-290F20.3 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[highly expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 RP11-286O1.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11-272L14.2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11‐256G5.1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)94) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-253E3.3 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 RP11-245P10.6 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11‑243M5.2 LncRNA Homo sapiens Stomach Neoplasms GC tissues Regulation qRT-PCR Following RT‑qPCR validation, AC016735.2, AP001626.1, RP11‑400N13.3 and RP11‑243M5.2 were considered to be consistent with the prediction of the bioinformatics analysis. Transcriptome sequencing and RT‑qPCR experiments identified 4 lncRNAs, including AC016735.2, AP001626.1, RP11‑400N13.3 and RP11‑243M5.2 to have an important role in the carcinogenesis of GC. No 29693709 RP11-241J12.3 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation(HBx ) qRT-PCR We also observed RP11-241J12.3 expression was upregulated in HCC tissues compared with the paracarcinomatous tissues. These results further our understanding of the lncRNAs regulated by HBx in HCC, and provide evidence that dysregulation of RP11-241J12.3 contributes to HCC aggressiveness. Furthermore, RP11-241J12.3 expression levels showed a close relationship with clinical stage and tumor size and that low RP11-241J12.3 expression was significantly correlated with longer HCC patient survival. No 35122182 RP11-231|13.2 LncRNA Homo sapiens Osteosarcoma osteosarcoma project Regulation Bioinformatics Analysis We developed a five-lncRNA signature as a potential prognostic indicator for osteosarcoma. The AUC for predicting 5-year survival was 0.745, which suggested good performance of the five-lncRNA signature. No 33964903 RP11-214O1.2 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[differently-expression] qRT-PCR//Microarray "The identified 199 lncRNAs were then analysed, retaining only those transcripts for which experimentally validated microRNA (miRNA) targets had already been annotated in starBase and, among these, only lncRNAs that targeted at least 10 miRNAs were selected. Using this approach, we obtained 6 lncRNAs, including CTD-2020K17.1, LINC00657, RP11-169K16.9, LINC00511, RP11-372K14.2 and RP11-214O1.2. (Table 2)" No 31480511 RP11-212I21.2 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[highly expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 RP11‐1L12.3 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)65) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11‐19P22.6 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)57) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-178F10.2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11-169K16.9 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[differently-expression] qRT-PCR//Microarray "The identified 199 lncRNAs were then analysed, retaining only those transcripts for which experimentally validated microRNA (miRNA) targets had already been annotated in starBase and, among these, only lncRNAs that targeted at least 10 miRNAs were selected. Using this approach, we obtained 6 lncRNAs, including CTD-2020K17.1, LINC00657, RP11-169K16.9, LINC00511, RP11-372K14.2 and RP11-214O1.2. (Table 2)" No 31480511 RP11-164N3.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11-161D15.1 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[lower expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 RP11-146D12.2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11-13A1.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11-128N14.5 LncRNA Homo sapiens Osteosarcoma osteosarcoma project Regulation Bioinformatics Analysis We developed a five-lncRNA signature as a potential prognostic indicator for osteosarcoma. The AUC for predicting 5-year survival was 0.745, which suggested good performance of the five-lncRNA signature. No 33964903 RP11‐119D9.4 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)85) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-114H24.7 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[lower expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 13 No 32547537 RP11-108K3.2 LncRNA Homo sapiens Colorectal Neoplasms blood Mutation[rs2470151 C/T] qRT-PCR//Genotyping In the discovery set, only the rs2470151 C/T polymorphism was found to have a promising association with the risk of colorectal cancer, and this polymorphism was further replicated in the validation set with a significantly decreased risk of colorectal cancer (adjusted odds ratio 0.73; 95% confidence interval 0.55, 0.97). Combined discovery set and validation set together, this negative association was found both in the heterozygote codominant model and the dominant model. Furthermore, colorectal cancer patients carrying rs2470151 CT/TT genotypes had a marginally lower RNA expression of RP11-108K3.2 than those carrying the CC genotype. Stratified analyses showed the association between rs2470151 and the risk of colorectal cancer were influenced by family history of cancer, smoking, alcohol consumption, and tea drinking. No 31789575 RP11-1072A3.3.1 LncRNA Homo sapiens Endometrial Neoplasms 301 UCEC patients Regulation Bioinformatics Analysis We detected a novel lncRNA-focus expression signature (LFES) consisting of 11 lncRNAs that were associated with survival based on risk scoring strategy in UCEC. The risk score based on the LFES was able to separate patients of discovery cohort into high-risk and low-risk groups with significantly different overall survival and progression-free survival, and has been successfully confirmed in the validation cohort. No 29304762 RP11‐106J23.1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)95) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP11-100E13.1 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[highly expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 RORA-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RNU4ATAC8P LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP11-89K10.1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR//Microarray Interestingly, we found several lncRNAs binding to Hes1 (such as, GNAS-AS1, RP11-89K10.1, and RP11-465L10.10) were up-regulated in CRC tissues showed by the tissue microarray. No 31700895 RP11‐954J6.3 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)13) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 SATB2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RPS6P10 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 724 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPS2P29 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 957 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPS28-201 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPS26P21 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 643 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPS24-207 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPS2-204 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPS21-205 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 RPS18P9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RPS18P5 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 810 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPS18P14 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1010 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPS15P4 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 805 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPS15P3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1026 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPS14P3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RPS13-207 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPS12P5 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 574 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPS11-209 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPS10P7 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RPS10P6 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 950 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPPH1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RPLP2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)105) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RPLP1-204 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPLP0P2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RPL9P16 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 846 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL9P11 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1043 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL9-210 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPL8-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPL7P7 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 604 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL7P49 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1029 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL7P16 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 835 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL7A-207 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPS3P7 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 905 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPS8-205 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPL6P8 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 697 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPS9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SATB2-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung TCGA(LUAD cancer and normal samples) Regulation Survival Analysis Herein, we identified an eight-lncRNA signature (PR-lncRNA signature, NPSR1-AS1, SATB2-AS1, LINC01090, FGF12-AS2, AC005256.1, MAFA-AS1, BFSP2-AS1, and CPC5-AS1), which contributes to predicting LUAD patient's prognosis risk and survival outcomes. Of them, NPSR1-AS1, SATB2-AS1, FGF12-AS2, and AC005256.1 could be acted as the poor prognosis markers, while LINC01090, MAFA-AS1, BFSP2-AS1, and CPC5-AS1 were treated as the protective factors for survival in LUAD patients. No 34550610 SARAF-202 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 SAR1AP3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 698 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 SAP30L-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 SAP30L-AS1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 793 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 SAMMSON LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Expression[highly expressed] qRT-PCR This study showed that the expression of SAMMSON was significantly increased in OSCC tissues and cell lines. High SAMMSON expression was significantly associated with TMN stage, tumour differentiation, lymph node metastasis distant metastasis and neighboring tissue infiltration. Patients with high expression of SAMMSON had poor overall survival and disease-free survival compared to those with low levels. Cox regression analysis showed that SAMMSON could act as an independent prognostic factor in OSCC. No 32952891 SALRNA1 LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[lower expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 SALL4P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 716 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 S100PBP LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 S100A16 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RUNXOR LncRNA Homo sapiens Lung Neoplasms peripheral blood Expression[highly expressed] qRT-PCR In this study, we found that the lncRNA RUNXOR was upregulated in the peripheral blood of lung cancer patients. No 29914443 RUNX2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RUNX1-IT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RUNX1-IT1 LncRNA Homo sapiens Graves Disease CD4+ T cells of GD patients Interaction(NrCAM ) RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//ELISA//ChIP The expressions of lncRNA RUNX1-IT1 and NrCAM were most significantly up-regulated in CD4+ T cells of GD patients, and NrCAM expression was significantly positively correlated with RUNX1-IT1 expression. Furthermore, p53 was a potential transcription factor of NrCAM, which could interact with NrCAM. NrCAM level was up-regulated after the overexpression of p53 in CD4+ T cells, while knockdown of RUNX1-IT1 reversed this effect. Down-regulation of NrCAM and RUNX1-IT1 could decrease the mRNA and protein levels of transcriptional regulator T-bet and CXC chemokine ligand 10 (CXCL10) in CD4+ T cells. No 35220890 RUNX1 LncRNA Homo sapiens Purpura, Thrombocytopenic, Idiopathic 100 patients with newly diagnosed ITP Expression(highly expressed) qRT-PCR GAS5 was under-expressed, while RUNX1 was over-expressed among the newly diagnosed ITP children compared with the control group. The best cut-off values of GAS5 and RUNX1 expression that predict chronic ITP were ?0.17 and ?4.1, respectively, yielding sensitivity of 88.89% and 77.78%, respectively. GAS5 and RUNX1 could be useful markers in children with primary ITP to predict disease course. No 36731007 RUNDC3A-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RUFY1-213 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RUBCNL LncRNA Homo sapiens Lung Neoplasms lung adenocarcinomas tissues Regulation(COX-2) qRT-PCR Our analysis of The Cancer Genome Atlas (TCGA) expression data revealed that PACER expression is significantly higher in lung adenocarcinomas than normal lung tissues. Additionally, we discovered that elevated PACER expression strongly correlates with COX-2 expression in lung adenocarcinoma patients. Specific siRNA-mediated knockdown of PACER decreases COX-2 expression indicating a direct relationship. No 35136486 RUBCNL LncRNA Homo sapiens Periodontitis blood Expression[highly expressed] qRT-PCR Expression of PACER was higher in total blood samples of patients compared with controls (Posterior beta of RE = 5.143, P value = 0.001). No 32426538 RTEL1-TNFRSF6B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RSRP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RRS1-DT LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 586 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RRN3P2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 561 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPSAP58 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RPSAP52 LncRNA Homo sapiens Glioblastoma GBM patients Expression[highly expressed] qRT-PCR//Western Blot The results showed that RPSAP52 was upregulated in GBM patients, and its high expression levels predicted poor survival. The results showed that RPSAP52 was upregulated in GBM patients, and its high expression levels predicted poor survival. No 32368136 RPSAP52 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RPSAP48 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 587 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPSAP36 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 560 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPSAP16 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 886 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL7A-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 RPL6P19 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 686 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RP11-977B10.2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RPL13A LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RPL10P16 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 1049 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL10A-205 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RP968-22D1.205 LncRNA Homo sapiens lung squamous cell carcinoma LUSC samples Expression[highly expressed] CCK8//Colony Formation Assay//Flow Cytometry//Western Blot Our results showed that CTD-2562J17.6 and FENDRR were significantly downregulated while MIR205HG, LNC_000378, RP11-116G8.5, RP3-523K23.2, and RP5-968D22.1 were significantly upregulated in all five LUSC samples. Importantly, MIR205HG was upregulated in LUSC clinical samples as well as in LUSC cell lines. No 32188965 RP6-99M1.2 LncRNA Homo sapiens Neuroblastoma Neuroblastoma tissues Expression[lower expressed] ChIP-seq//RNA-seq Differential analysis revealed nine significantly differentially expressed (more than 2-fold change with corrected p-value) lncRNAs between tumor cells and matched MNCs. Of these, RFPL1S (p = 0.0001), PPP1R26-AS1 (p = 0.03), RP11-439E19.3 (p = 1.24 × 10–6), CASC15 (p = 1.6 × 10–7), AC004540.5 (p = 0.0002), and CTD-2881E23.2 (p = 1.6 × 10–9) were found to be significantly Expression[up-expression]regulated (Figure 1B), while USP3-AS1 (p = 1.78 × 10–6), CHRM3-AS2 (p = 0.003) and RP6-99M1.2 (p = 0.002) were significantly downregulated (Figure 1C). No 31920530 RP5-998N21.4 LncRNA Homo sapiens Schizophrenia SK-N-SH cell lines Regulation(IFIT2/IFIT3) RNA Pull-Down//Western Blot//RIP//RNA-seq//ChIP Finally, we observed that RP5-998N21.4OE can enhance IFIT2- and IFIT3-mediated immune defense responses through activation of signal transducer and activator of transcription 1 (STAT1) signaling pathway in U251 astrocytoma cells under treatment with the viral mimetic polyinosinic: polycytidylic acid (poly I:C). taken together, our findings suggest that lncRNA RP5-998N21.4 is a critical regulator of immune defense, providing etiological and therapeutic implications for schizophrenia. No 35232977 RP5-977B1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung exosomal Expression(highly expressed) qRT-PCR//Western Blot On the basis of analysis, we found that novel exosomal LncRNA RP5-977B1 exhibited higher levels in NSCLC than that in the healthy controls. The area under the curve (AUC) value of exosomal RP5-977B1 was 0.8899 and superior to conventional biomarkers CEA and CYFRA21-1 both in testing and multicentric validation cohort. Interestingly, the diagnostic capability of exosomal RP5-977B1 was also validated in early-stage patients with NSCLC. Furthermore, high expression of exosomal RP5-977B1was closely related with worse prognosis in NSCLC (P = 0.036). The area under the curve (AUC) value of exosomal RP5-977B1 was 0.8899 and superior to conventional biomarkers CEA and CYFRA21-1 both in testing and multicentric validation cohort. Interestingly, the diagnostic capability of exosomal RP5-977B1 was also validated in early-stage patients with NSCLC. Furthermore, high expression of exosomal RP5-977B1was closely related with worse prognosis in NSCLC (P = 0.036). No 35482171 RP5‐903G2.2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)16) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP5-894D12.4 LncRNA Homo sapiens Osteosarcoma osteosarcoma project Regulation Bioinformatics Analysis We developed a five-lncRNA signature as a potential prognostic indicator for osteosarcoma. The AUC for predicting 5-year survival was 0.745, which suggested good performance of the five-lncRNA signature. No 33964903 RP5‐875H18.4 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)23) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP5-837J1.2 LncRNA Homo sapiens Ovarian Neoplasms blood Expression[highly expressed] qRT-PCR The current study reported, for the first time, upregulation of serum lncRNA RP5-837J1.2 with concomitant downregulation of miR-361-3p and PELI3 mRNA in malignant group compared with benign and controls groups. No 31520466 RP5-827C21.6 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP5-827C21.2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP523-23K2.5 LncRNA Homo sapiens lung squamous cell carcinoma LUSC samples Expression[highly expressed] CCK8//Colony Formation Assay//Flow Cytometry//Western Blot Our results showed that CTD-2562J17.6 and FENDRR were significantly downregulated while MIR205HG, LNC_000378, RP11-116G8.5, RP3-523K23.2, and RP5-968D22.1 were significantly upregulated in all five LUSC samples. Importantly, MIR205HG was upregulated in LUSC clinical samples as well as in LUSC cell lines. No 32188965 RP5-1065P14.2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP4-781 K5.7.1 LncRNA Homo sapiens Endometrial Neoplasms 301 UCEC patients Regulation Bioinformatics Analysis We detected a novel lncRNA-focus expression signature (LFES) consisting of 11 lncRNAs that were associated with survival based on risk scoring strategy in UCEC. The risk score based on the LFES was able to separate patients of discovery cohort into high-risk and low-risk groups with significantly different overall survival and progression-free survival, and has been successfully confirmed in the validation cohort. No 29304762 RP4‐680D5.2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)30) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP4‐620F22.3 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)11) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP4-576H24.2 LncRNA Homo sapiens Leukemia, Myeloid, Acute cell line Expression[highly expressed] qRT-PCR Further in vitro experiments showed that lncRNA RP4-576H24.2 was upregulated in AML cell lines compared to normal bone marrow mononuclear cells (BMMCs), and promoted proliferation while inhibited apoptosis in HL-60 and KG-1 cells. No 31568697 RP439-19E3.1 LncRNA Homo sapiens Neuroblastoma Neuroblastoma tissues Expression[Expression[highly expressed]-expression] ChIP-seq//RNA-seq Differential analysis revealed nine significantly differentially expressed (more than 2-fold change with corrected p-value) lncRNAs between tumor cells and matched MNCs. Of these, RFPL1S (p = 0.0001), PPP1R26-AS1 (p = 0.03), RP11-439E19.3 (p = 1.24 × 10–6), CASC15 (p = 1.6 × 10–7), AC004540.5 (p = 0.0002), and CTD-2881E23.2 (p = 1.6 × 10–9) were found to be significantly Expression[up-expression]regulated (Figure 1B), while USP3-AS1 (p = 1.78 × 10–6), CHRM3-AS2 (p = 0.003) and RP6-99M1.2 (p = 0.002) were significantly downregulated (Figure 1C). No 31920530 RP3-467L1.4 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP3-466P17.2 LncRNA Homo sapiens Lung Neoplasms tumor educated platelet Expression(lower expressed) qRT-PCR TEP linc-GTF2H2-1 and RP3-466P17.2 were significantly downregulated, while lnc-ST8SIA4-12 was significantly upregulated in patients with lung cancer or with early-stage lung cancer as compared to healthy donors, possessing AUCs of 0.781, 0.788, 0.725 for lung cancer and 0.704, 0.771, 0.768 for early-stage lung cancer, respectively. No 33792796 RP3-446N13.5 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 RP3-414A15.10 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 RP3‐400B16.3 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)29) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP1-6M1.4 LncRNA Homo sapiens Arthritis, Rheumatoid keen synovial tissues Expression[lower expressed] qRT-PCR Results of RT-qPCR showed that the levels of lncRNAs MTCO2P12, KCNQ5-IT1 and RP11-83J16.1 were increased, whereas lncRNAs LINC00570, RP11-342M1.6, and REXO1L8P were decreased in RA patients compared to controls. No 32355550 RP1‐66C13.3 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)109) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RP16-1J00570.11 LncRNA Homo sapiens Arthritis, Rheumatoid keen synovial tissues Expression[highly expressed] qRT-PCR Results of RT-qPCR showed that the levels of lncRNAs MTCO2P12, KCNQ5-IT1 and RP11-83J16.1 were increased, whereas lncRNAs LINC00570, RP11-342M1.6, and REXO1L6P were decreased in RA patients compared to controls. No 32355550 RP13-216E22.5 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[lower expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 14 No 32547537 RP1‐257I20.13 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)4) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RPL10P9 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 770 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL13AP20 LncRNA Homo sapiens Colorectal Neoplasms CRC tumor samples Expression[highly expressed] qRT-PCR In this study, levels of HANR were significantly higher in CRC tumor samples relative to adjacent normal tissue samples (P < .001). In addition, elevated HANR expression was positively correlated with more advanced and aggressive CRC features, such as a larger tumor size (P = .003), increased invasion depth (P = .012), and more advanced TNM stage (P = .011). Survival analyses revealed that elevated HANR expression was correlated with worse overall survival (P = .002) and disease-free survival (P = .003). No 32049807 RPL5-210 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPL13AP20 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RPL4-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 RPL4-202 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPL39P3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 538 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL37P18 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 978 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL36A-205 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPL35AP9 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 765 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL35AP2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 540 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL35A-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPL34P35 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 855 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL3-217 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPL30-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPL27A-207 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPL26-207 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPL23AP79 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 800 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL23AP64 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RPL23AP35 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 981 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL21P99 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 939 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL21P44 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RPL21P32 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 956 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL21P28 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RPL21P10 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 815 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL19-206 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPL18AP3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 945 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 RPL17-213 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 RPL15P3 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)26) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 RPL15 CircRNA Homo sapiens Glioma glioma tissues regulation[Circ-RPL15/miR-146b-3p/VEGFA feedback loop] qPCR//PCR//IF Circ-RPL15 and VEGFA were upregulated in glioma tissues than normal ones, whereas miR-146b-3p was downregulated.Circ-RPL15 triggers proliferative and migratory potentials in glioma by competitively binding miR-146b-3p and thus upregulates VEGFA. No 32572886 RPL13P5 LncRNA Homo sapiens Diabetes, Gestational peripheral blood Expression [highly expressed] RNA Network//qPCR The lncRNA RPL13p5 forms a co-expression strand with the TSC2 gene via the PI3K-Akt signaling pathway. The sequencing of lncRNA RPL13P5 showed high expression and the qPCR validation results were consistent with the sequencing results. No 34763465 RPL13AP6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 RPL13AP5 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 HOTAIRM1 LncRNA Homo sapiens Carcinoma, Renal Cell cell lines(HK-2, ACHN and CAKI-1 ) Expression[lower expressed] qRT-PCR//RNA-seq//Western Blot We show that the major HOTAIRM1 transcript in differentiated cells is the spliced cytoplasmic HM1-3 isoform and that HM1-3 is downregulated in >90% of clear cell renal cell carcinomas (ccRCCs). No 31862408 HOTAIR LncRNA Homo sapiens Stomach Neoplasms tissues Regulation qRT-PCR//RNA-seq The results of our study demonstrated that the five-lncRNAs PART1, UCA1, DIRC3, HOTAIR, and HOXA11AS require more investigation to be confirmed as diagnostic biomarkers in gastric cancer. No 35949302 hsa_circ_005932 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1711 No 31026505 hsa_circ_001784 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.308 No 31026505 hsa_circ_005718 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.294 No 31026505 hsa_circ_007089 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.295 No 31026505 hsa_circ_002030 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.296 No 31026505 hsa_circ_007191 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.297 No 31026505 hsa_circ_002963 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.298 No 31026505 hsa_circ_002993 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.299 No 31026505 hsa_circ_005400 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.300 No 31026505 hsa_circ_005767 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.301 No 31026505 hsa_circ_000459 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.302 No 31026505 hsa_circ_000860 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.303 No 31026505 hsa_circ_002540 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.304 No 31026505 hsa_circ_003453 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.305 No 31026505 hsa_circ_006162 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.306 No 31026505 hsa_circ_005367 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.307 No 31026505 hsa_circ_006809 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.309 No 31026505 hsa_circ_005795 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.655 No 31026505 hsa_circ_006488 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.310 No 31026505 hsa_circ_004418 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.311 No 31026505 hsa_circ_005153 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.312 No 31026505 hsa_circ_003721 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.313 No 31026505 hsa_circ_002522 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.314 No 31026505 hsa_circ_003991 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.315 No 31026505 hsa_circ_003977 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.316 No 31026505 hsa_circ_001261 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.317 No 31026505 hsa_circ_000183 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.318 No 31026505 hsa_circ_006719 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.319 No 31026505 hsa_circ_004961 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.320 No 31026505 hsa_circ_006943 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.321 No 31026505 hsa_circ_003085 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.322 No 31026505 hsa_circ_004135 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.323 No 31026505 hsa_circ_001085 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.293 No 31026505 hsa_circ_006109 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.292 No 31026505 hsa_circ_001520 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.291 No 31026505 hsa_circ_001938 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.290 No 31026505 hsa_circ_000606 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.261 No 31026505 hsa_circ_004208 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.262 No 31026505 hsa_circ_005900 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.263 No 31026505 hsa_circ_004356 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.264 No 31026505 hsa_circ_006323 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.265 No 31026505 hsa_circ_002907 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.266 No 31026505 hsa_circ_002685 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.267 No 31026505 hsa_circ_003503 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.268 No 31026505 hsa_circ_000465 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.269 No 31026505 hsa_circ_001920 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.270 No 31026505 hsa_circ_000521 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.271 No 31026505 hsa_circ_006771 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.272 No 31026505 hsa_circ_007313 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.273 No 31026505 hsa_circ_004655 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.274 No 31026505 hsa_circ_003902 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.275 No 31026505 hsa_circ_004993 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.276 No 31026505 hsa_circ_003280 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.277 No 31026505 hsa_circ_006191 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.278 No 31026505 hsa_circ_003407 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.279 No 31026505 hsa_circ_004269 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.280 No 31026505 hsa_circ_003318 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.281 No 31026505 hsa_circ_002140 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.282 No 31026505 hsa_circ_000629 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.283 No 31026505 hsa_circ_006434 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.284 No 31026505 hsa_circ_003396 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.285 No 31026505 hsa_circ_002781 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.286 No 31026505 hsa_circ_005145 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.287 No 31026505 hsa_circ_004924 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.288 No 31026505 hsa_circ_000202 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.289 No 31026505 hsa_circ_003925 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.324 No 31026505 hsa_circ_003496 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.325 No 31026505 hsa_circ_003951 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.326 No 31026505 hsa_circ_001029 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.359 No 31026505 hsa_circ_005697 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.361 No 31026505 hsa_circ_001610 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.362 No 31026505 hsa_circ_002742 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.363 No 31026505 hsa_circ_001929 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.364 No 31026505 hsa_circ_001193 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.365 No 31026505 hsa_circ_005630 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.366 No 31026505 hsa_circ_002361 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.367 No 31026505 hsa_circ_000220 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.368 No 31026505 hsa_circ_000546 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.369 No 31026505 hsa_circ_005131 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.370 No 31026505 hsa_circ_001826 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.371 No 31026505 hsa_circ_003546 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.372 No 31026505 hsa_circ_004925 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.373 No 31026505 hsa_circ_006464 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.374 No 31026505 hsa_circ_002894 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.375 No 31026505 hsa_circ_002754 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.376 No 31026505 hsa_circ_001317 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.377 No 31026505 hsa_circ_003581 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.378 No 31026505 hsa_circ_005737 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.379 No 31026505 hsa_circ_002511 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.380 No 31026505 hsa_circ_000634 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.381 No 31026505 hsa_circ_000176 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.382 No 31026505 hsa_circ_003089 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.383 No 31026505 hsa_circ_003189 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.384 No 31026505 hsa_circ_002608 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.385 No 31026505 hsa_circ_001803 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.386 No 31026505 hsa_circ_001842 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.387 No 31026505 hsa_circ_002613 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.388 No 31026505 hsa_circ_005249 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.389 No 31026505 hsa_circ_002413 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.360 No 31026505 hsa_circ_005185 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.358 No 31026505 hsa_circ_003419 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.327 No 31026505 hsa_circ_002268 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.357 No 31026505 hsa_circ_000412 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.328 No 31026505 hsa_circ_005601 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.329 No 31026505 hsa_circ_004948 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.330 No 31026505 hsa_circ_004105 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.331 No 31026505 hsa_circ_005833 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.332 No 31026505 hsa_circ_004806 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.333 No 31026505 hsa_circ_005011 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.334 No 31026505 hsa_circ_005346 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.335 No 31026505 hsa_circ_005890 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.336 No 31026505 hsa_circ_006870 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.337 No 31026505 hsa_circ_002182 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.338 No 31026505 hsa_circ_004106 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.339 No 31026505 hsa_circ_004785 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.340 No 31026505 hsa_circ_002837 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.341 No 31026505 hsa_circ_002842 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.342 No 31026505 hsa_circ_004565 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.343 No 31026505 hsa_circ_002912 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.344 No 31026505 hsa_circ_002808 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.345 No 31026505 hsa_circ_004765 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.346 No 31026505 hsa_circ_003090 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.347 No 31026505 hsa_circ_004221 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.348 No 31026505 hsa_circ_006465 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.349 No 31026505 hsa_circ_000033 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.350 No 31026505 hsa_circ_004253 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.351 No 31026505 hsa_circ_005360 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.352 No 31026505 hsa_circ_000136 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.353 No 31026505 hsa_circ_002449 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.354 No 31026505 hsa_circ_000051 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.355 No 31026505 hsa_circ_004128 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.356 No 31026505 hsa_circ_006261 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.260 No 31026505 hsa_circ_004007 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.259 No 31026505 hsa_circ_006017 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.258 No 31026505 hsa_circ_004694 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.160 No 31026505 hsa_circ_000121 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.162 No 31026505 hsa_circ_005219 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.163 No 31026505 hsa_circ_004668 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.164 No 31026505 hsa_circ_002526 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.165 No 31026505 hsa_circ_007062 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.166 No 31026505 hsa_circ_004369 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.167 No 31026505 hsa_circ_007087 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.168 No 31026505 hsa_circ_003417 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.169 No 31026505 hsa_circ_000002 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.170 No 31026505 hsa_circ_004647 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.171 No 31026505 hsa_circ_001911 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.172 No 31026505 hsa_circ_004855 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.173 No 31026505 hsa_circ_003481 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.174 No 31026505 hsa_circ_002568 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.175 No 31026505 hsa_circ_005955 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.176 No 31026505 hsa_circ_001573 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.177 No 31026505 hsa_circ_004856 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.178 No 31026505 hsa_circ_004745 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.179 No 31026505 hsa_circ_004278 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.180 No 31026505 hsa_circ_000282 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.181 No 31026505 hsa_circ_006262 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.182 No 31026505 hsa_circ_006441 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.183 No 31026505 hsa_circ_004775 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.184 No 31026505 hsa_circ_003625 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.185 No 31026505 hsa_circ_005364 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.186 No 31026505 hsa_circ_006443 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.187 No 31026505 hsa_circ_002418 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.188 No 31026505 hsa_circ_006451 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.189 No 31026505 hsa_circ_001225 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.190 No 31026505 hsa_circ_002221 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.161 No 31026505 hsa_circ_002326 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.159 No 31026505 hsa_circ_006796 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.192 No 31026505 hsa_circ_006026 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.158 No 31026505 hsa_circ_002279 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.129 No 31026505 hsa_circ_005014 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.130 No 31026505 hsa_circ_004059 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.131 No 31026505 hsa_circ_007107 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.132 No 31026505 hsa_circ_007106 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.133 No 31026505 hsa_circ_006760 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.134 No 31026505 hsa_circ_000150 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.135 No 31026505 hsa_circ_006212 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.136 No 31026505 hsa_circ_006082 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.137 No 31026505 hsa_circ_005939 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.138 No 31026505 hsa_circ_006592 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.139 No 31026505 hsa_circ_007063 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.140 No 31026505 hsa_circ_001912 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.141 No 31026505 hsa_circ_006703 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.142 No 31026505 hsa_circ_003080 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.143 No 31026505 hsa_circ_005133 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.144 No 31026505 hsa_circ_001695 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.145 No 31026505 hsa_circ_002577 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.146 No 31026505 hsa_circ_002057 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.147 No 31026505 hsa_circ_001207 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.148 No 31026505 hsa_circ_005132 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.149 No 31026505 hsa_circ_001387 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.150 No 31026505 hsa_circ_007163 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.151 No 31026505 hsa_circ_003466 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.152 No 31026505 hsa_circ_003723 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.153 No 31026505 hsa_circ_003001 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.154 No 31026505 hsa_circ_005373 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.155 No 31026505 hsa_circ_002610 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.156 No 31026505 hsa_circ_007003 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.157 No 31026505 hsa_circ_006745 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.191 No 31026505 hsa_circ_005938 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.193 No 31026505 hsa_circ_006727 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.257 No 31026505 hsa_circ_004966 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.226 No 31026505 hsa_circ_006759 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.228 No 31026505 hsa_circ_004910 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.229 No 31026505 hsa_circ_005586 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.230 No 31026505 hsa_circ_003256 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.231 No 31026505 hsa_circ_004944 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.232 No 31026505 hsa_circ_004023 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.233 No 31026505 hsa_circ_002847 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.234 No 31026505 hsa_circ_006630 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.235 No 31026505 hsa_circ_002092 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.236 No 31026505 hsa_circ_006080 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.237 No 31026505 hsa_circ_004393 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.238 No 31026505 hsa_circ_001673 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.239 No 31026505 hsa_circ_003418 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.240 No 31026505 hsa_circ_001355 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.241 No 31026505 hsa_circ_002790 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.242 No 31026505 hsa_circ_000104 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.243 No 31026505 hsa_circ_007110 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.244 No 31026505 hsa_circ_002819 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.245 No 31026505 hsa_circ_001919 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.246 No 31026505 hsa_circ_004675 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.247 No 31026505 hsa_circ_004248 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.248 No 31026505 hsa_circ_002738 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.249 No 31026505 hsa_circ_007193 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.250 No 31026505 hsa_circ_005842 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.251 No 31026505 hsa_circ_005668 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.252 No 31026505 hsa_circ_004637 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.253 No 31026505 hsa_circ_001323 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.254 No 31026505 hsa_circ_006244 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.255 No 31026505 hsa_circ_001405 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.256 No 31026505 hsa_circ_004995 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.227 No 31026505 hsa_circ_004894 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.225 No 31026505 hsa_circ_003137 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.194 No 31026505 hsa_circ_003112 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.224 No 31026505 hsa_circ_005780 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.195 No 31026505 hsa_circ_005230 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.196 No 31026505 hsa_circ_001190 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.197 No 31026505 hsa_circ_000015 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.198 No 31026505 hsa_circ_000395 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.199 No 31026505 hsa_circ_001585 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.200 No 31026505 hsa_circ_003379 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.201 No 31026505 hsa_circ_002434 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.202 No 31026505 hsa_circ_005657 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.203 No 31026505 hsa_circ_002258 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.204 No 31026505 hsa_circ_004227 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.205 No 31026505 hsa_circ_000850 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.206 No 31026505 hsa_circ_003302 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.207 No 31026505 hsa_circ_006614 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.208 No 31026505 hsa_circ_007024 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.209 No 31026505 hsa_circ_007081 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.210 No 31026505 hsa_circ_002688 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.211 No 31026505 hsa_circ_006898 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.212 No 31026505 hsa_circ_000315 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.213 No 31026505 hsa_circ_006717 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.214 No 31026505 hsa_circ_000201 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.215 No 31026505 hsa_circ_004395 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.216 No 31026505 hsa_circ_004923 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.217 No 31026505 hsa_circ_002119 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.218 No 31026505 hsa_circ_003408 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.219 No 31026505 hsa_circ_005626 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.220 No 31026505 hsa_circ_001647 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.221 No 31026505 hsa_circ_000466 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.222 No 31026505 hsa_circ_000692 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.223 No 31026505 hsa_circ_001611 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.390 No 31026505 hsa_circ_000310 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.391 No 31026505 hsa_circ_005380 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.392 No 31026505 hsa_circ_006467 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.557 No 31026505 hsa_circ_001755 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.559 No 31026505 hsa_circ_001521 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.560 No 31026505 hsa_circ_002962 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.561 No 31026505 hsa_circ_001941 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.562 No 31026505 hsa_circ_005513 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.563 No 31026505 hsa_circ_001954 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.564 No 31026505 hsa_circ_001474 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.565 No 31026505 hsa_circ_000470 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.566 No 31026505 hsa_circ_001955 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.567 No 31026505 hsa_circ_004577 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.568 No 31026505 hsa_circ_004455 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.569 No 31026505 hsa_circ_007098 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.570 No 31026505 hsa_circ_004636 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.571 No 31026505 hsa_circ_006068 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.572 No 31026505 hsa_circ_000983 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.573 No 31026505 hsa_circ_000001 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.574 No 31026505 hsa_circ_003570 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.575 No 31026505 hsa_circ_004764 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.576 No 31026505 hsa_circ_003660 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.577 No 31026505 hsa_circ_004907 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.578 No 31026505 hsa_circ_005994 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.579 No 31026505 hsa_circ_002622 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.580 No 31026505 hsa_circ_003448 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.581 No 31026505 hsa_circ_001164 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.582 No 31026505 hsa_circ_003217 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.583 No 31026505 hsa_circ_006990 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.584 No 31026505 hsa_circ_005022 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.585 No 31026505 hsa_circ_003510 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.586 No 31026505 hsa_circ_002870 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.587 No 31026505 hsa_circ_000657 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.558 No 31026505 hsa_circ_005377 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.556 No 31026505 hsa_circ_000472 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.589 No 31026505 hsa_circ_000904 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.555 No 31026505 hsa_circ_007202 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.526 No 31026505 hsa_circ_005194 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.527 No 31026505 hsa_circ_006221 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.528 No 31026505 hsa_circ_000915 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.529 No 31026505 hsa_circ_002368 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.530 No 31026505 hsa_circ_005924 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.531 No 31026505 hsa_circ_003559 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.532 No 31026505 hsa_circ_000770 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.533 No 31026505 hsa_circ_003516 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.534 No 31026505 hsa_circ_004594 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.535 No 31026505 hsa_circ_004817 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.536 No 31026505 hsa_circ_003390 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.537 No 31026505 hsa_circ_001388 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.538 No 31026505 hsa_circ_002592 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.539 No 31026505 hsa_circ_001450 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.540 No 31026505 hsa_circ_003321 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.541 No 31026505 hsa_circ_000116 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.542 No 31026505 hsa_circ_004932 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.543 No 31026505 hsa_circ_003719 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.544 No 31026505 hsa_circ_005804 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.545 No 31026505 hsa_circ_002573 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.546 No 31026505 hsa_circ_003201 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.547 No 31026505 hsa_circ_001026 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.548 No 31026505 hsa_circ_000373 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.549 No 31026505 hsa_circ_003935 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.550 No 31026505 hsa_circ_004264 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.551 No 31026505 hsa_circ_001646 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.552 No 31026505 hsa_circ_006854 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.553 No 31026505 hsa_circ_000639 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.554 No 31026505 hsa_circ_002609 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.588 No 31026505 hsa_circ_002246 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.590 No 31026505 hsa_circ_007253 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.524 No 31026505 hsa_circ_006710 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.623 No 31026505 hsa_circ_002047 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.625 No 31026505 hsa_circ_001884 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.626 No 31026505 hsa_circ_001986 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.627 No 31026505 hsa_circ_004918 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.628 No 31026505 hsa_circ_005162 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.629 No 31026505 hsa_circ_005374 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.630 No 31026505 hsa_circ_005708 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.631 No 31026505 hsa_circ_000771 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.632 No 31026505 hsa_circ_000110 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.633 No 31026505 hsa_circ_004693 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.634 No 31026505 hsa_circ_006621 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.635 No 31026505 hsa_circ_007243 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.636 No 31026505 hsa_circ_006831 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.637 No 31026505 hsa_circ_004170 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.638 No 31026505 hsa_circ_002256 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.639 No 31026505 hsa_circ_005879 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.640 No 31026505 hsa_circ_003506 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.641 No 31026505 hsa_circ_006048 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.642 No 31026505 hsa_circ_001820 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.643 No 31026505 hsa_circ_006405 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.644 No 31026505 hsa_circ_005739 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.645 No 31026505 hsa_circ_003446 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.646 No 31026505 hsa_circ_006962 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.647 No 31026505 hsa_circ_006879 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.648 No 31026505 hsa_circ_001238 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.649 No 31026505 hsa_circ_004085 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.650 No 31026505 hsa_circ_004164 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.651 No 31026505 hsa_circ_002673 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.652 No 31026505 hsa_circ_007161 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.653 No 31026505 hsa_circ_002419 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.624 No 31026505 hsa_circ_000640 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.622 No 31026505 hsa_circ_002941 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.591 No 31026505 hsa_circ_000749 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.621 No 31026505 hsa_circ_004992 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.592 No 31026505 hsa_circ_002414 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.593 No 31026505 hsa_circ_005655 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.594 No 31026505 hsa_circ_004970 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.595 No 31026505 hsa_circ_002968 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.596 No 31026505 hsa_circ_005654 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.597 No 31026505 hsa_circ_000471 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.598 No 31026505 hsa_circ_007076 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.599 No 31026505 hsa_circ_001396 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.600 No 31026505 hsa_circ_004283 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.601 No 31026505 hsa_circ_005488 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.602 No 31026505 hsa_circ_005761 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.603 No 31026505 hsa_circ_003209 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.604 No 31026505 hsa_circ_002482 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.605 No 31026505 hsa_circ_006342 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.606 No 31026505 hsa_circ_003509 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.607 No 31026505 hsa_circ_001697 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.608 No 31026505 hsa_circ_005471 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.609 No 31026505 hsa_circ_002668 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.610 No 31026505 hsa_circ_005908 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.611 No 31026505 hsa_circ_000463 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.612 No 31026505 hsa_circ_002337 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.613 No 31026505 hsa_circ_006692 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.614 No 31026505 hsa_circ_003017 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.615 No 31026505 hsa_circ_001445 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.616 No 31026505 hsa_circ_003374 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.617 No 31026505 hsa_circ_005139 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.618 No 31026505 hsa_circ_001043 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.619 No 31026505 hsa_circ_001939 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.620 No 31026505 hsa_circ_002344 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.525 No 31026505 hsa_circ_000778 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.523 No 31026505 hsa_circ_002905 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.393 No 31026505 hsa_circ_000283 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.425 No 31026505 hsa_circ_007088 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.427 No 31026505 hsa_circ_002315 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.428 No 31026505 hsa_circ_003109 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.429 No 31026505 hsa_circ_003818 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.430 No 31026505 hsa_circ_005193 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.431 No 31026505 hsa_circ_005074 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.432 No 31026505 hsa_circ_000811 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.433 No 31026505 hsa_circ_003225 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.434 No 31026505 hsa_circ_003765 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.435 No 31026505 hsa_circ_006790 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.436 No 31026505 hsa_circ_005891 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.437 No 31026505 hsa_circ_002022 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.438 No 31026505 hsa_circ_006979 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.439 No 31026505 hsa_circ_001073 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.440 No 31026505 hsa_circ_001922 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.441 No 31026505 hsa_circ_002153 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.442 No 31026505 hsa_circ_003248 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.443 No 31026505 hsa_circ_002980 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.444 No 31026505 hsa_circ_006224 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.445 No 31026505 hsa_circ_002036 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.446 No 31026505 hsa_circ_001608 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.447 No 31026505 hsa_circ_005788 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.448 No 31026505 hsa_circ_003018 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.449 No 31026505 hsa_circ_003300 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.450 No 31026505 hsa_circ_002690 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.451 No 31026505 hsa_circ_004529 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.452 No 31026505 hsa_circ_002925 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.453 No 31026505 hsa_circ_007181 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.454 No 31026505 hsa_circ_006863 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.455 No 31026505 hsa_circ_000519 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.426 No 31026505 hsa_circ_004991 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.424 No 31026505 hsa_circ_005485 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.457 No 31026505 hsa_circ_000662 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.423 No 31026505 hsa_circ_004155 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.394 No 31026505 hsa_circ_000582 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.395 No 31026505 hsa_circ_002183 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.396 No 31026505 hsa_circ_005240 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.397 No 31026505 hsa_circ_002707 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.398 No 31026505 hsa_circ_004736 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.399 No 31026505 hsa_circ_002706 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.400 No 31026505 hsa_circ_002172 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.401 No 31026505 hsa_circ_003279 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.402 No 31026505 hsa_circ_003324 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.403 No 31026505 hsa_circ_006311 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.404 No 31026505 hsa_circ_004372 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.405 No 31026505 hsa_circ_003138 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.406 No 31026505 hsa_circ_000394 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.407 No 31026505 hsa_circ_004548 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.408 No 31026505 hsa_circ_007166 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.409 No 31026505 hsa_circ_007159 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.410 No 31026505 hsa_circ_001119 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.411 No 31026505 hsa_circ_000539 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.412 No 31026505 hsa_circ_003183 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.413 No 31026505 hsa_circ_006995 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.414 No 31026505 hsa_circ_006791 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.415 No 31026505 hsa_circ_000114 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.416 No 31026505 hsa_circ_000168 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.417 No 31026505 hsa_circ_007158 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.418 No 31026505 hsa_circ_002297 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.419 No 31026505 hsa_circ_002056 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.420 No 31026505 hsa_circ_004824 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.421 No 31026505 hsa_circ_005062 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.422 No 31026505 hsa_circ_003216 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.456 No 31026505 hsa_circ_004989 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.458 No 31026505 hsa_circ_006755 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.522 No 31026505 hsa_circ_004534 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.491 No 31026505 hsa_circ_005535 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.493 No 31026505 hsa_circ_005771 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.494 No 31026505 hsa_circ_001284 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.495 No 31026505 hsa_circ_003988 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.496 No 31026505 hsa_circ_001744 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.497 No 31026505 hsa_circ_001067 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.498 No 31026505 hsa_circ_004052 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.499 No 31026505 hsa_circ_004448 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.500 No 31026505 hsa_circ_005460 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.501 No 31026505 hsa_circ_001883 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.502 No 31026505 hsa_circ_000753 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.503 No 31026505 hsa_circ_004223 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.504 No 31026505 hsa_circ_006718 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.505 No 31026505 hsa_circ_003573 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.506 No 31026505 hsa_circ_000804 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.507 No 31026505 hsa_circ_002643 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.508 No 31026505 hsa_circ_000158 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.509 No 31026505 hsa_circ_002135 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.510 No 31026505 hsa_circ_000246 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.511 No 31026505 hsa_circ_005602 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.512 No 31026505 hsa_circ_006064 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.513 No 31026505 hsa_circ_000871 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.514 No 31026505 hsa_circ_005114 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.515 No 31026505 hsa_circ_000789 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.516 No 31026505 hsa_circ_000313 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.517 No 31026505 hsa_circ_004528 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.518 No 31026505 hsa_circ_002029 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.519 No 31026505 hsa_circ_003013 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.520 No 31026505 hsa_circ_002147 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.521 No 31026505 hsa_circ_006981 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.492 No 31026505 hsa_circ_004535 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.490 No 31026505 hsa_circ_000970 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.459 No 31026505 hsa_circ_004641 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.489 No 31026505 hsa_circ_001651 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.460 No 31026505 hsa_circ_002813 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.461 No 31026505 hsa_circ_002824 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.462 No 31026505 hsa_circ_007064 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.463 No 31026505 hsa_circ_000927 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.464 No 31026505 hsa_circ_003455 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.465 No 31026505 hsa_circ_000605 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.466 No 31026505 hsa_circ_005929 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.467 No 31026505 hsa_circ_002986 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.468 No 31026505 hsa_circ_001539 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.469 No 31026505 hsa_circ_001751 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.470 No 31026505 hsa_circ_004832 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.471 No 31026505 hsa_circ_006163 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.472 No 31026505 hsa_circ_004612 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.473 No 31026505 hsa_circ_002009 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.474 No 31026505 hsa_circ_001660 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.475 No 31026505 hsa_circ_000296 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.476 No 31026505 hsa_circ_001362 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.477 No 31026505 hsa_circ_000680 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.478 No 31026505 hsa_circ_002184 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.479 No 31026505 hsa_circ_001538 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.480 No 31026505 hsa_circ_004336 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.481 No 31026505 hsa_circ_000822 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.482 No 31026505 hsa_circ_004152 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.483 No 31026505 hsa_circ_006385 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.484 No 31026505 hsa_circ_006386 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.485 No 31026505 hsa_circ_001337 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.486 No 31026505 hsa_circ_005080 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.487 No 31026505 hsa_circ_004747 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.488 No 31026505 hsa_circ_001975 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.128 No 31026505 hsa_circ_007213 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.127 No 31026505 hsa_circ_006966 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.126 No 31026505 circSOD2 CircRNA Homo sapiens Carcinoma, Renal Cell urine from ccRCC patients compared to healthy controls Expression [lower expressed] qRT-PCR We observed significantly reduced levels of circEGLN3 and circSOD2 in urine from ccRCC patients compared to healthy controls. We also assessed the linear variant of EGLN3 and found differential expression between patients with benign tumors compared to ccRCC patients. No 35174071 circENGLN3 CircRNA Homo sapiens Carcinoma, Renal Cell 121 ccRCC and 91 normal renal tissues Expression [highly expressed] qRT-PCR circEHD2, circENGLN3, and circNETO2 were upregulated in ccRCC compared with non-malignant renal tissue.   circENGLN3 expression was highly discriminative between normal and cancerous tissue.  No 33946584 circNETO2 CircRNA Homo sapiens Carcinoma, Renal Cell 121 ccRCC and 91 normal renal tissues Expression [highly expressed] qRT-PCR circEHD2, circENGLN3, and circNETO2 were upregulated in ccRCC compared with non-malignant renal tissue.  High circEHD2 and low circNETO2 levels were an independent predictor of a shortened progression-free survival, cancer-specific survival, and overall survival in patients with ccRCC undergoing nephrectomy. No 33946584 hsa_circ_0007474 CircRNA Homo sapiens Osteoarthritis OA knee condyle Expression[differently expression] CCK8//qRT-PCR//ELISA//Western Blot A total of 197 differentially expressed circRNAs, such as hg38_circ_0007474 and hg38_circ_0000118 were identified, and 21 target miRNAs, 2466 source genes and 166 394 circRNA-miRNA-mRNA pairs were predicted. No 31111536 hsa_circ_0000118 CircRNA Homo sapiens Osteoarthritis OA knee condyle Expression[differently expression] CCK8//qRT-PCR//ELISA//Western Blot A total of 197 differentially expressed circRNAs, such as hg38_circ_0007474 and hg38_circ_0000118 were identified, and 21 target miRNAs, 2466 source genes and 166 394 circRNA-miRNA-mRNA pairs were predicted. No 31111536 hsa_circ_0045714 CircRNA Homo sapiens Osteoarthritis OA knee condyle Expression[differently expression] CCK8//qRT-PCR//ELISA//Western Blot A total of 197 differentially expressed circRNAs, such as hg38_circ_0007474 and hg38_circ_0000118 were identified, and 21 target miRNAs, 2466 source genes and 166 394 circRNA-miRNA-mRNA pairs were predicted. No 31111536 hsa_circ_0002485 CircRNA Homo sapiens Osteoarthritis OA knee condyle Expression[differently expression] CCK8//qRT-PCR//ELISA//Western Blot A total of 197 differentially expressed circRNAs, such as hg38_circ_0007474 and hg38_circ_0000118 were identified, and 21 target miRNAs, 2466 source genes and 166 394 circRNA-miRNA-mRNA pairs were predicted. No 31111536 hsa_circ_0005567 CircRNA Homo sapiens Osteoarthritis OA knee condyle Expression[differently expression] CCK8//qRT-PCR//ELISA//Western Blot A total of 197 differentially expressed circRNAs, such as hg38_circ_0007474 and hg38_circ_0000118 were identified, and 21 target miRNAs, 2466 source genes and 166 394 circRNA-miRNA-mRNA pairs were predicted. No 31111536 hsa_circ_0032131 CircRNA Homo sapiens Osteoarthritis blood Expression[highly expressed] qRT-PCR In this study, using a qRT-PCR we confirmed the upregulated expression of hsa_circ_0032131_CBC1 in peripheral blood of OA patients compared with healthy controls, which was consistent with the results of chondrocyte verification. No 31526191 circDHRS1 CircRNA Homo sapiens Osteoarthritis OA cartilage tissues regulation[regulating GREM1 expression,targeting miR-183-5p] qRT-PCR//IF//RNA Pull-Down//Western Blot Circ_DHRS3 expression was elevated in OA cartilage tissues and IL-1β-treated chondrocytes. Circ_DHRS3 mediated IL-1β-administered chondrocyte proliferation, apoptosis and ECM degradation by positively regulating GREM1 expression via competitively targeting miR-183-5p. No 33360372 circTMBIM6 CircRNA Homo sapiens Osteoarthritis cartilage tissue regulation[miR-27a/MMP13 axis] qRT-PCR The expression levels of circTMBIM6 and MMP13 in cartilage tissue of patients with osteoarthritis were higher than that of normal group, while the expression level of miR-195 in cartilage tissue of patients with osteoarthritis was lower. CircTMBIM6 promotes osteoarthritis-induced chondrocyte extracellular matrix degradation via miR-27a/MMP13 axis. No 32767318 circRUNX2 CircRNA Homo sapiens Osteoarthritis serum Expression [highly expressed] Microarray RUNX2-derived hsa_circ_0005526 (circ_RUNX2) is significantly highly expressed in OA serum and mainly located in the cytoplasm within the cartilage cell by sponging multiple miRNAs (miR-498, miR-924, miR-361-3p, and miR-665). No 34165827 hsa_circ_016901 CircRNA Homo sapiens Osteoarthritis tissues Expression(highly expressed) qRT-PCR Compared to HCs, increased accumulation of circRNA-016901 was only observed in the OA group, but not in the RA and ON groups before treatment. Plasma expression of circRNA-016901 was closely associated with OA patients' disease severity. No 35707381 hsa_circ_0128298 CircRNA Homo sapiens Carcinoma, Hepatocellular cancer tissues Expression[highly expressed] qRT-PCR The expression levels of hsa_circ_0128298 in HCC were significantly higher than those of paratumorous tissues (P<0.001). The overall survival of patients with low hsa_circ_0128298 expression was significantly higher than that of patients with high hsa_circ_0128298 expression. No 29849467 SCD-circ_2 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC Tumor and adjacent non-tumor tissue Interaction[RBM3 ] Northern Blot//Western Blot//qRT-PCR//RIP//RNA-seq//EdU Staining We analyzed its circRNA expression using a qRT-PCR in 20 pairs of HCC and adjacent non-tumor tissues. Using a melting curve, electrophoresis and production of PCR sequencing data, we confirmed that the primers for SCD-circRNA 1 (circ_novel_4976) and SCD-circRNA 2 (circ_novel_4982) were correct. Further results indicated that SCD-circRNA 1 and SCD-circRNA 2 were Expression[Expression[up-expression]-expression]regulated in tumor tissues compared with their expression in adjacent non-tumor tissues, consistent with the results obtained by direct sequencing (n = 20, Fig. 1d).Moreover, we observed that the production of SCD-circRNA 2 was dynamically regulated by RNA-binding protein 3 (RBM3). RBM3 overexpression was indicative of a short recurrence-free survival and poor overall survival for HCC patients. Furthermore, by modulating the RBM3 or SCD-circRNA 2 levels, we found that RBM3 promoted the HCC cell proliferation in a SCD-circRNA 2 dependent manner. Next, we examined whether the SCD-circRNA 1 or SCD-circRNA 2 expression level of HCC tissues correlated with clinical outcome of HCC patients after hepatectomy in cohort 2. Using Kaplan-Meier survival curves, we found that patients with a higher SCD-circRNA 2 expression levels exhibited both worse recurrence-free survival (RFS; P = .001; Fig. 2a) and overall survival (OS; P = .000; Fig. 2b). Significantly, the multivariate analysis revealed that high SCD-circRNA 2 expression level in HCC tissues was an independent predictor for reduced RFS and OS in HCC patients (Fig. 2c-d). SCD-circRNA 1 expression levels were not associated with HCC patient outcome after hepatectomy. No 31235426 hsa_circ_0078602 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue Expression[Expression[lower expressed]-expression] qRT-PCR//Microarray It was identified that the expression of hsa_circ_0078602 and hsa_circ_0018764 were significantly and consistently decreased in HCC tissues compared with matched samples (Fig. 2A and D). No 30675276 hsa_circ_0018764 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue Expression[Expression[lower expressed]-expression] qRT-PCR//Microarray It was identified that the expression of hsa_circ_0078602 and hsa_circ_0018764 were significantly and consistently decreased in HCC tissues compared with matched samples (Fig. 3A and D). No 30675276 hsa_circ_0094117 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue Expression[No differently] qRT-PCR//Microarray However, there was no significant difference in the expression of hsa_circ_0094117 between the tumor and the healthy tissues (Fig. 2B). Furthermore, the expression of hsa_circ_0127245 was increased in the tumor tissue compared with the adjacent tissue, in contradiction to the microarray result No 30675276 hsa_circ_0127245 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissue Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//Microarray However, there was no significant difference in the expression of hsa_circ_0094117 between the tumor and the healthy tissues (Fig. 2B). Furthermore, the expression of hsa_circ_0127245 was increased in the tumor tissue compared with the adjacent tissue, in contradiction to the microarray result No 30675276 hsa_circ_103809 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[miR-620] Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay The results showed that hsa_circ_103809 expression was significantly Expression[down-expression]- regulated in HCC tissues and cell lines. The ectopic expression of hsa_circ_103809 inhibited HCC cell proliferation, migration and invasion. In addition, we found that miR-620 expression was significantly Expression[Expression[up-expression]-expression]-regulated in HCC tissues and was negatively correlated with hsa_circ_103809 expression in HCC tissues. Furthermore, we found that hsa_circ_103809 could bind to miR-620 and that hsa_circ_103809 negatively regulates miR-620 expression. We also showed that hsa_circ_103809 inhibited the proliferation and invasion abilities of HCC cells by sponging miR-620. No 30720163 hsa_circ_0009910 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR key gene and the hsa_circ_0009910-miR-1261-UBE2L3 regulatory axis was established. The relative expression of the regulatory axis members was confirmed by qRT-PCR in 30 pairs of samples, including HCC tissues and adjacent nontumor tissues. The results suggested that hsa_circ_0009910, which was upregulated in HCC tissues, participates in the pathogenesis of HCC by acting as a sponge of miR-1261 to regulate the expression of UBE2L3. No 31886256 hsa_circ_0005505 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR//RNA-seq To validate the sequencing data, six circRNAs, representing three of the up‐regulated circRNAs (circ_0005505, circ_0001394, and circRNA_0000798) and three of the down‐regulated circRNAs (circ_0004771, circ_0001074, and circRNA_0067735) (Table 2), were randomly selected from the 58 significantly dysregulated circRNAs (Table S1) for validation by qRT‐PCR using PBMCs of 72 HCC patients and 30 healthy controls. No 30714679 hsa_circ_0000798 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR//RNA-seq To validate the sequencing data, six circRNAs, representing three of the up‐regulated circRNAs (circ_0005505, circ_0001394, and circRNA_0000798) and three of the down‐regulated circRNAs (circ_0004771, circ_0001074, and circRNA_0067735) (Table 2), were randomly selected from the 58 significantly dysregulated circRNAs (Table S1) for validation by qRT‐PCR using PBMCs of 72 HCC patients and 30 healthy controls. No 30714679 hsa_circ_0001394 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR//RNA-seq To validate the sequencing data, six circRNAs, representing three of the up‐regulated circRNAs (circ_0005505, circ_0001394, and circRNA_0000798) and three of the down‐regulated circRNAs (circ_0004771, circ_0001074, and circRNA_0067735) (Table 2), were randomly selected from the 58 significantly dysregulated circRNAs (Table S1) for validation by qRT‐PCR using PBMCs of 72 HCC patients and 30 healthy controls. No 30714679 hsa_circ_0001074 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[lower expressed] qRT-PCR//RNA-seq To validate the sequencing data, six circRNAs, representing three of the up‐regulated circRNAs (circ_0005505, circ_0001394, and circRNA_0000798) and three of the down‐regulated circRNAs (circ_0004771, circ_0001074, and circRNA_0067735) (Table 2), were randomly selected from the 58 significantly dysregulated circRNAs (Table S1) for validation by qRT‐PCR using PBMCs of 72 HCC patients and 30 healthy controls. No 30714679 hsa_circ_0004771 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[lower expressed] qRT-PCR//RNA-seq To validate the sequencing data, six circRNAs, representing three of the up‐regulated circRNAs (circ_0005505, circ_0001394, and circRNA_0000798) and three of the down‐regulated circRNAs (circ_0004771, circ_0001074, and circRNA_0067735) (Table 2), were randomly selected from the 58 significantly dysregulated circRNAs (Table S1) for validation by qRT‐PCR using PBMCs of 72 HCC patients and 30 healthy controls. No 30714679 hsa_circ_0067735 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[lower expressed] qRT-PCR//RNA-seq To validate the sequencing data, six circRNAs, representing three of the up‐regulated circRNAs (circ_0005505, circ_0001394, and circRNA_0000798) and three of the down‐regulated circRNAs (circ_0004771, circ_0001074, and circRNA_0067735) (Table 2), were randomly selected from the 58 significantly dysregulated circRNAs (Table S1) for validation by qRT‐PCR using PBMCs of 72 HCC patients and 30 healthy controls. No 30714679 circEHD2 CircRNA Homo sapiens Carcinoma, Renal Cell 121 ccRCC and 91 normal renal tissues Expression [highly expressed] qRT-PCR circEHD2, circENGLN3, and circNETO2 were upregulated in ccRCC compared with non-malignant renal tissue. High circEHD2 and low circNETO2 levels were an independent predictor of a shortened progression-free survival, cancer-specific survival, and overall survival in patients with ccRCC undergoing nephrectomy. No 33946584 circEGLN3 CircRNA Homo sapiens Carcinoma, Renal Cell urine from ccRCC patients compared to healthy controls Expression [lower expressed] qRT-PCR We observed significantly reduced levels of circEGLN3 and circSOD2 in urine from ccRCC patients compared to healthy controls. We also assessed the linear variant of EGLN3 and found differential expression between patients with benign tumors compared to ccRCC patients. No 35174071 hsa_circ_0000517 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR To verify our initial finding, the expression of hsa_circ_0000517 in 60 HCC patients was detected by qRT-PCR and the expression in cancer tissues was higher compared with the paracarcinoma tissues. Survival analysis suggests high hsa_circ_0000517 expression was associated with adverse prognosis in HCC patients. Furthermore, this circRNA was significantly up-regulated in worse TNM stage, consistent with the progressive-stage-specific characteristic of circRNAs. A prognostic nomogram built on AFP and has_circ_0000517 showed significant diagnostic value. No 31750237 circPRRC2A CircRNA Homo sapiens Carcinoma, Renal Cell RCC tissues Expression[highly expressed] qRT-PCR//Microarray We found that increased expression of circPRRC2A is positively associated with advanced clinical stage and worse survivorship in RCC patients. We found that increased expression of circPRRC2A is positively associated with advanced clinical stage and worse survivorship in RCC patients. No 32292503 hsa_circ_0007843 CircRNA Homo sapiens Colonic Neoplasms colon cancer tissue Expression[highly expressed] qRT-PCR By using RT-PCR, we confirmed that the expression of hsa_circ_0007843, hsa_circ_0010575, hsa_circ_0007331, and hsa_circ_0001615 was significantly higher in colon cancer tissue than in normal colonic tissue. No 32158464 hsa_circ_0010575 CircRNA Homo sapiens Colonic Neoplasms colon cancer tissue Expression[highly expressed] qRT-PCR By using RT-PCR, we confirmed that the expression of hsa_circ_0007843, hsa_circ_0010575, hsa_circ_0007331, and hsa_circ_0001615 was significantly higher in colon cancer tissue than in normal colonic tissue. No 32158464 hsa_circ_0007331 CircRNA Homo sapiens Colonic Neoplasms colon cancer tissue Expression[highly expressed] qRT-PCR By using RT-PCR, we confirmed that the expression of hsa_circ_0007843, hsa_circ_0010575, hsa_circ_0007331, and hsa_circ_0001615 was significantly higher in colon cancer tissue than in normal colonic tissue. No 32158464 hsa_circ_0001615 CircRNA Homo sapiens Colonic Neoplasms colon cancer tissue Expression[highly expressed] qRT-PCR By using RT-PCR, we confirmed that the expression of hsa_circ_0007843, hsa_circ_0010575, hsa_circ_0007331, and hsa_circ_0001615 was significantly higher in colon cancer tissue than in normal colonic tissue. No 32158464 circBNC2 CircRNA Homo sapiens Carcinoma, Ovarian Epithelial blood Expression[highly expressed] qRT-PCR//ELISA CircBNC2 is downregulated in EOC and warrants investigation in a screening study in females at risk for EOC. No 32009804 hsa_circ_007293 CircRNA Homo sapiens Thyroid Cancer, Papillary blood Expression[highly expressed] qRT-PCR "The results from qRT-PCR showed that the expression of hsacirc_007293 and hsacirc_031752 genes were upregulated in the patients with papillary thyroid carcinoma, and the expression of the hsacirc_020135 gene was upregulated (Figure 5). These data were consistent with the results from high-throughput sequencing. " No 30988274 hsa_circ_031752 CircRNA Homo sapiens Thyroid Cancer, Papillary blood Expression[highly expressed] qRT-PCR "The results from qRT-PCR showed that the expression of hsacirc_007293 and hsacirc_031752 genes were upregulated in the patients with papillary thyroid carcinoma, and the expression of the hsacirc_020135 gene was upregulated (Figure 5). These data were consistent with the results from high-throughput sequencing. " No 30988274 hsa_circ_0000277 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [highly expressed] RNA Pull-Down//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Transwell Assay In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0044556 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [highly expressed] RNA Pull-Down//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Transwell Assay In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0014234 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [highly expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0040773 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [highly expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0074530 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [highly expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0074595 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [highly expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0001681 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [highly expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0049237 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [highly expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0058230 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [highly expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0057691 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [highly expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_FGFR2 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [lower expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0095448 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [lower expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0031968 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [lower expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_IPCEF1 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [lower expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0021549 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [lower expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0070098 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [lower expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0079891 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [lower expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0001938 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [lower expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0020396 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [lower expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0021550 CircRNA Homo sapiens Thyroid Cancer, Papillary 57 pairs of subjects(whole blood from patients) Expression [lower expressed] qRT-PCR In total, 158 dysregulated circRNAs were identified in PTC tumors relative to adjacent normal tissues. Notably, one downregulated circRNA (hsa_circ_IPCEF1) showed the preferable predictive power (AUC=0.8010, P<0.0001) and interactions with four cancer‑related genes (CASR, CDC25B, NFκB1 and SHOC2). No 34165176 hsa_circ_0015278 CircRNA Homo sapiens Thyroid Cancer, Papillary tumor tissues Expression [lower expressed] Bioinformatics Analysis Circ_0015278 was reduced in tumor tissues compared with adjacent tissues (p < 0.001), and receiver operating characteristic analysis showed that it well discriminated tumor tissues from adjacent tissues (area under curve: 0.903, 95% confidence interval: 0.874-0.932). Besides, higher tumor circ_0015278 expression was correlated with absence of extrathyroidal invasion (p = 0.036), lower pathological tumor (pT) stage (p = 0.05), pathological node (pN) stage (p = 0.002), and pathological tumor-node-metastasis (pTNM) stage (p = 0.001). No 33969549 hsa_circ_0054537 CircRNA Homo sapiens Carcinoma, Renal Cell RCC cells interaction[miR-130a-3p] qRT-PCR//Luciferase Report Assay//RIP Then we predicted the underlyingly upstream modulator of miR-130a-3p was a novel circRNA hsa_circ_0054537, which exhibited dysregulated in RCC cells. In conclusion, we demonstrated that circRNA hsa_circ_0054537 functioned as a competitive endogenous RNA to regulate cMet expression via sponging miR-130a-3p in renal cancer. No 32464246 hsa_circ_0064428 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Regulated[down-regulated] qRT-PCR//IHC//Microarray . Among them, the expression of hsa_circ_0064428 was significantly reduced in patients with HCC with high TILs but increased in patients with low TILs. Among them, the expression of hsa_circ_0064428 was significantly reduced in patients with HCC with high TILs but increased in patients with low TILs. Moreover, hsa_circ_0064428 was negatively correlated with patient's survival, tumour size and metastasis. No 30120213 hsa_circ_0028502 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR Our data demonstrated that the hsa_circ_0028502 and hsa_circ_0076251 levels were considerably lower in HCC tissues than in adjacent paracancerous tissues (P < .001). Further study revealed that hsa_circ_0028502 expression levels were related to tumor node metastasis (TNM) stage (P = .015) and that hsa_circ_0076251 expression levels were related to Barcelona Clinic Liver Cancer (BCLC) stage (P = .038), comorbidity with type 2 diabetes mellitus (P = .023) and the presence of serum HbsAg (P = .044). No 31595711 hsa_circ_052666 CircRNA Homo sapiens Colonic Neoplasms colon tissues Expression[highly expressed] qRT-PCR//RNA-seq As displayed in Figure 9, circ_022743 was significantly downregulated in both ES and LS colon tumor tissues compared with those in normal tissues, while circ_052666 was markedly upregulated in both ES and LS colon tumor tissues. Moreover, circ_004452 was only downregulated in LS colon tumor tissues in comparison with that in normal colon tissues. No 32799546 hsa_circ_0028129 CircRNA Homo sapiens Carcinoma, Hepatocellular 233 frozen tumour specimens and paired para-tumour normal background liver tissues Expression [lower expressed] qRT-PCR We found using high-throughput sequencing that seven candidate circRNAs (hsa_circ_0041150, hsa_circ_0025624, hsa_circ_0001020, hsa_circ_0028129, hsa_circ_0008558, hsa_circ_0036683, hsa_circ_0058087) were downregulated in HCC. No 33727578 hsa_circ_0036683 CircRNA Homo sapiens Carcinoma, Hepatocellular 233 frozen tumour specimens and paired para-tumour normal background liver tissues Expression [lower expressed] qRT-PCR We found using high-throughput sequencing that seven candidate circRNAs (hsa_circ_0041150, hsa_circ_0025624, hsa_circ_0001020, hsa_circ_0028129, hsa_circ_0008558, hsa_circ_0036683, hsa_circ_0058087) were downregulated in HCC. Kaplan-Meier analysis revealed that low expression of hsa_circ_0001020, hsa_circ_0036683, and hsa_circ_0058087 was associated with poor recurrence-free (RFS) and overall survival (OS) in HCC. No 33727578 hsa_circ_0058087 CircRNA Homo sapiens Carcinoma, Hepatocellular 233 frozen tumour specimens and paired para-tumour normal background liver tissues Expression [lower expressed] qRT-PCR We found using high-throughput sequencing that seven candidate circRNAs (hsa_circ_0041150, hsa_circ_0025624, hsa_circ_0001020, hsa_circ_0028129, hsa_circ_0008558, hsa_circ_0036683, hsa_circ_0058087) were downregulated in HCC. Kaplan-Meier analysis revealed that low expression of hsa_circ_0001020, hsa_circ_0036683, and hsa_circ_0058087 was associated with poor recurrence-free (RFS) and overall survival (OS) in HCC. No 33727578 circPTPRA CircRNA Homo sapiens Carcinoma, Hepatocellular Liver cancer cell lines Huh-7 and HCCLM3 and the human normal hepatocyte cell line THLE-2 Interaction(miR-582-3p) Western Blot//Migration Assay//Flow Cytometry//RIP//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay Compared with the human normal hepatocyte cell line, THLE-2, the expression levels of circRNA_PTPRA were upregulated, which were found to be inversely correlated with those of miR-582-3p expression in Huh-7 and HCCLM3 cells. No 34594413 hsa_circ_0005397 CircRNA Homo sapiens Carcinoma, Hepatocellular plasma of patients with HCC Expression [highly expressed] qRT-PCR The expression of plasma hsa_circ_0005397 was higher in patients with HCC than that in patients with benign liver diseases and healthy controls (both p < 0.05). Besides, the increased plasma hsa_cic_0005397 was closely correlated with shorter overall survival of HCC patients Moreover, it was closely correlated with tumor size (p = 0.020) and TNM stage (p = 0.006) of HCC patients. The area under the ROC curve of plasma hsa_circ_0005397 was 0.737 and 95% confidence interval was 0.671-0.795. Besides, the increased plasma hsa_cic_0005397 was closely correlated with shorter overall survival of HCC patients No 33679420 circHIPK3 CircRNA Homo sapiens Carcinoma, Hepatocellular hepatocellular carcinoma (HCC) tissues Interaction(miR-124-3p and miR-4524-5p) qRT-PCR//Luciferase Report Assay//Western Blot Circular RNA in vivo precipitation and luciferase reporter assays demonstrated that circHIPK3, as a competitive endogenous RNA, binds with miR-124-3p and miR-4524-5p. Further, knockdown of circHIPK3 resulted in downregulation of MRP4 protein, whereas cotransfection of circHIPK3-siRNA and miR-124-3p or miR-4524-5p inhibitors restored its expression. No 33946595 circMEMO1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC samples Interaction(TCF21) qRT-PCR//IHC//Western Blot We found that circMEMO1 was significantly downregulated in HCC samples and that the level of circMEMO1 was closely related to the OS and disease-free survival (DFS) of HCC patients. Mechanistic analysis revealed that circMEMO1 can modulate the promoter methylation and gene expression of TCF21 to regulate HCC progression by acting as a sponge for miR-106b-5p, which targets the TET family of genes and increases the 5hmC level. We found that circMEMO1 was significantly downregulated in HCC samples and that the level of circMEMO1 was closely related to the OS and disease-free survival (DFS) of HCC patients. No 33985545 hsa_circ_0004913 CircRNA Homo sapiens Carcinoma, Hepatocellular tumor tissue Expression(lower expressed) qRT-PCR Circ_0004913 (p < 0.001) and circ_0008160 (p < 0.001) were downregulated, while circ_0000517 (p < 0.001) was upregulated in tumor tissue compared with paired adjacent tissue. Additionally, tumor circ_0004913 was negatively associated with largest tumor size (p = 0.009) and Barcelona clinic liver cancer (BCLC) stage (p = 0.020), while tumor circ_0008160 and circ_0000517 were not correlated with any clinicopathological features of HCC patients (all p > 0.05). Tumor circ_0004913 high expression was associated with prolonged OS in total HCC patients (p = 0.008) and in subgroup of patients with largest tumor size <5 cm (p = 0.008). No 34018640 hsa_circ_0008160 CircRNA Homo sapiens Carcinoma, Hepatocellular tumor tissue Expression(lower expressed) qRT-PCR Circ_0004913 (p < 0.001) and circ_0008160 (p < 0.001) were downregulated, while circ_0000517 (p < 0.001) was upregulated in tumor tissue compared with paired adjacent tissue. Tumor circ_0008160 high expression was correlated with longer OS in patients with BCLC stage B (p = 0.026). No 34018640 hsa_circ_0000517 CircRNA Homo sapiens Carcinoma, Hepatocellular tumor tissue Expression(highly expressed) qRT-PCR Circ_0004913 (p < 0.001) and circ_0008160 (p < 0.001) were downregulated, while circ_0000517 (p < 0.001) was upregulated in tumor tissue compared with paired adjacent tissue. No 34018640 circARPP21 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC cells Interaction(miR-543/LIFR) CCK8//qRT-PCR//RNA Pull-Down In this study, we found that a novel circRNA, circARPP21 (hsa_circ_0123629), exerts a strong effect on HCC progression.Conversely, higher expression of circARPP21 can increase leukemia inhibitory factor receptor (LIFR) expression by sponging miR-543. Finally, overexpression of miR-543 can reverse the anti-proliferation and anti-metastasis effects of circARPP21. Reduced expression of circARPP21 in HCC patients is correlated with larger tumor size, higher tug-lymph node metastasis (TNM) stage, and poor prognosis as indicated by elevated levels of alpha-fetoprotein (AFP). No 33584097 hsa_circ_0005986 CircRNA Homo sapiens Carcinoma, Hepatocellular 123 HCC tissue samples Expression(lower expressed) qRT-PCR Hsa_circ_0005986 expression was downregulated in HCC tissues. Low hsa_circ_0005986 expression was more common in tumors larger than 5 cm [odds ratio (OR), 3.19; 95% confidence interval (CI), 1.51-6.76; p = 0.002], advanced TNM stage (III/IV; OR, 2.39; 95% CI, 1.16-4.95; p = 0.018), and higher BCLC stage (B/C; OR, 2.71; 95% CI, 1.30-5.65; p = 0.007). Hsa_circ_0005986 expression was downregulated in HCC tissues. Low hsa_circ_0005986 expression was more common in tumors larger than 5 cm [odds ratio (OR), 3.19; 95% confidence interval (CI), 1.51-6.76; p = 0.002], advanced TNM stage (III/IV; OR, 2.39; 95% CI, 1.16-4.95; p = 0.018), and higher BCLC stage (B/C; OR, 2.71; 95% CI, 1.30-5.65; p = 0.007). No 34294754 hsa_circ_0064286 CircRNA Homo sapiens Carcinoma, Hepatocellular Sixty clinically diagnosed HCC Egyptian patients and 25 healthy volunteers Expression(lower expressed) qRT-PCR Both circular RNAs were significantly down regulated in HCC patients, which was negatively correlated with ALP, ALT, AST, AFP, and bilirubin levels. Circ_0064286 showed more sensitivity and specificity (88.3% and 96%, respectively). No 34582677 hsa_circ_0001438 CircRNA Homo sapiens Carcinoma, Hepatocellular primary HCC and cell lines Expression(lower expressed) qRT-PCR The expression level of hsa_circ_0001438, a circRNA that was downregulated in primary HCC, was lower in poorly and well-differentiated HCC cell lines than in normal hepatocytes. By contrast, the expression level of hsa_circ_0000417, which was increased in primary HCC, was strongly upregulated in a well-differentiated HCC cell line compared with normal hepatocytes. No 36153641 hsa_circ_0000417 CircRNA Homo sapiens Carcinoma, Hepatocellular primary HCC and cell lines Expression(highly expressed) qRT-PCR The expression level of hsa_circ_0001438, a circRNA that was downregulated in primary HCC, was lower in poorly and well-differentiated HCC cell lines than in normal hepatocytes. By contrast, the expression level of hsa_circ_0000417, which was increased in primary HCC, was strongly upregulated in a well-differentiated HCC cell line compared with normal hepatocytes. No 36153641 hsa_circ_0000437 CircRNA Homo sapiens Carcinoma, Hepatocellular tumor tissues and serum Expression(highly expressed) qRT-PCR Circ_0000437 expression was markedly upregulated in the tumor group compared with the control group and was correlated with tumor node metastasis (TNM) classification, differentiation degree, tumor size, and Barcelona Clinic Liver Cancer (BCLC) stage (P< 0.05) in both the tumor tissues and serum Circ_0000437 expression was markedly upregulated in the tumor group compared with the control group and was correlated with tumor node metastasis (TNM) classification, differentiation degree, tumor size, and Barcelona Clinic Liver Cancer (BCLC) stage (P< 0.05) in both the tumor tissues and serum. Furthermore, poor overall survival (OS) was correlated with high circ_0000437 expression, and the area under the ROC curve (AUC) of circ_0000437 for the diagnosis of HCC was 0.9281 in the serum. No 35730467 hsa_circ_0006091 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC patient Regulation qRT-PCR//Bioinformatics Analysis The obtained results revealed the significantly differential expression of hsa_circ_0006091 in HCC.. The joint diagnosis of the hsa_circ_0006091&AFP and hsa_circ_0006091&RGS12 has diagnostic significance and can be used as a molecular marker for HCC diagnosis. Furthermore, hsa_circ_0006091 is a novel candidate biomarker for HCC and could improve the diagnostic strategies, prediction, and follow-up of HCC patients. No 35068348 hsa_circ_0070934 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation qRT-PCR This study implies the potential pathogenesis of the obtained network and proposes that the two DECs (has_circ_0070934 and has_circ_0004315) may be important prognostic markers for HCC. No 35322101 hsa_circ_0004315 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation qRT-PCR This study implies the potential pathogenesis of the obtained network and proposes that the two DECs (has_circ_0070934 and has_circ_0004315) may be important prognostic markers for HCC. No 35322101 hsa_circ_0071662 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC patients Expression(lower expressed) qRT-PCR Compared to HCs, decreased plasma levels of Circ_0071662 were only observed in HCC patients, but not in other patient groups. HCC tissues also exhibited decreased expression levels of Circ_0071662 compared to non-tumor samples. Decreased plasma Circ_0071662 separated HCC patients from HCs and other patient groups. Decreased plasma levels of Circ_0071662 were closely associated with patients' poor survival. Plasma and tissue Circ_0071662 were closely associated with patients' tumor metastasis and tumor size. No 36279855 hsa_circ_0003570 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression(lower expressed) qRT-PCR Hsa_circ_0003570 expression was downregulated in HCC tissues. Low hsa_circ_0003570 expression was more common in tumors larger than 5 cm (odds ratio (OR), 6.369; 95% confidence interval (CI), 2.725?14.706; p < 0.001), vessel invasion (OR, 5.128; 95% CI, 2.288?11.494; p < 0.001); advanced tumor-node metastasis stage (III/IV; OR, 4.082; 95% CI, 1.866?8.929; p < 0.001); higher Barcelona Clinic Liver Cancer stage (B/C; OR, 3.215; 95% CI, 1.475?6.993; p = 0.003); and higher AFP (>200 ng/mL; OR, 2.475; 95% CI, 1.159?5.291; p = 0.018). No 36011395 circHIPK3 CircRNA Homo sapiens Ovarian Neoplasms EOC tissues and cells Expression[highly expressed] qRT-PCR We found that circHIPK3 was higher expressed in EOC tissues and cells compared to adjacent normal tissue and ovarian epithelium cell line, respectively. Higher circHIPK3 expression associated with lymph node invasion, FIGO stage, and worse DFS and OS of patients. Moreover, multivariate Cox analysis showed that higher circHIPK3 was an independent predictor of DFS and OS in EOC patients. No 29949144 hsa_circ_0002711 CircRNA Homo sapiens Ovarian Neoplasms Serum Expression [differentially expressed] qRT-PCR//circRNA-seq//RNA-seq These 5 circRNAs exhibited increased differential expression in OC compared with normal samples. No 31589961 hsa_circ_0001756 CircRNA Homo sapiens Ovarian Neoplasms Serum Expression [differentially expressed] qRT-PCR//circRNA-seq//RNA-seq These 5 circRNAs exhibited increased differential expression in OC compared with normal samples. No 31589961 hsa_circ_0001068 CircRNA Homo sapiens Ovarian Neoplasms blood Expression[highly expressed] qRT-PCR As with the training set, results from the larger cohort revealed that levels of circ-0001068 in the exosomes were significantly higher in ovarian cancer patients than healthy volunteers. No 33028742 circEXOC6B CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Expression[lower expressed] qRT-PCR The level of circEXOC6B was notably decreased in ovarian cancer tissues. No 33006481 hsa_circ_0003972 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer patients' plasma, tissues, and cell lines Expression(lower expressed) qRT-PCR Hsa_circ_0003972 and hsa_circ_0007288 were downregulated in ovarian cancer patients' plasma, tissues, and cell lines, comparing with the controls. Furthermore, the higher expression level of hsa_circ_0007288 in both plasma and ovarian cancer tissues was associated with lower lymph node metastasis potential in ovarian cancer. No 35550610 hsa_circ_0007288 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer patients' plasma, tissues, and cell lines Expression(lower expressed) qRT-PCR Hsa_circ_0003972 and hsa_circ_0007288 were downregulated in ovarian cancer patients' plasma, tissues, and cell lines, comparing with the controls. Furthermore, the higher expression level of hsa_circ_0007288 in both plasma and ovarian cancer tissues was associated with lower lymph node metastasis potential in ovarian cancer. No 35550610 circFBXO7 CircRNA Homo sapiens Ovarian Neoplasms ovarian cancer cell Interaction(circFBXO7/miR-96-5p/MTSS1 axis) CCK8//qRT-PCR//Luciferase Report Assay circFBXO7 was downregulated in ovarian cancer which was associated with poor prognosis. Biologically, circFBXO7 overexpression significantly suppressed ovarian cancer cell proliferation, migration, and invasion in vitro, and inhibited tumor growth and metastasis in vivo, whereas its knockdown exerted an opposite role. Mechanistically, circFBXO7 functioned as a competing endogenous RNA for miR-96-5p to regulate the expression of MTSS1. Consequently, downregulation of MTSS1 led to excessive accumulation of β-catenin and increased phosphorylation of GSK3β, leading to the translocation of β-catenin to the nucleus, thereby activating the Wnt/β-catenin signaling pathway and ultimately promoting ovarian cancer progression. circFBXO7 was downregulated in ovarian cancer which was associated with poor prognosis. Biologically, circFBXO7 overexpression significantly suppressed ovarian cancer cell proliferation, migration, and invasion in vitro, and inhibited tumor growth and metastasis in vivo, whereas its knockdown exerted an opposite role. No 35768865 hsa_circ_000542 CircRNA Homo sapiens Urinary Bladder Neoplasms cell lines(CCC-HB-2,SW780, 5637, T24, J82 and RT4) Expression[highly expressed] qRT-PCR Further qPCR results confirmed that has_circRNA_000542, has_circRNA_403658, has_circRNA_001747, has_circRNA_103868, and has_circRNA_030448 were significantly increased in hypoxia-cultured 5637 cells compared with normal-cultured cells No 31814891 hsa_circ_0008558 CircRNA Homo sapiens Carcinoma, Hepatocellular 233 frozen tumour specimens and paired para-tumour normal background liver tissues Expression [lower expressed] qRT-PCR We found using high-throughput sequencing that seven candidate circRNAs (hsa_circ_0041150, hsa_circ_0025624, hsa_circ_0001020, hsa_circ_0028129, hsa_circ_0008558, hsa_circ_0036683, hsa_circ_0058087) were downregulated in HCC. No 33727578 hsa_circ_0001020 CircRNA Homo sapiens Carcinoma, Hepatocellular 233 frozen tumour specimens and paired para-tumour normal background liver tissues Expression [lower expressed] qRT-PCR We found using high-throughput sequencing that seven candidate circRNAs (hsa_circ_0041150, hsa_circ_0025624, hsa_circ_0001020, hsa_circ_0028129, hsa_circ_0008558, hsa_circ_0036683, hsa_circ_0058087) were downregulated in HCC. Kaplan-Meier analysis revealed that low expression of hsa_circ_0001020, hsa_circ_0036683, and hsa_circ_0058087 was associated with poor recurrence-free (RFS) and overall survival (OS) in HCC. Additionally, multivariate analysis revealed that low hsa_circ_0036683 expression was a significant prognostic factor, independent from other clinicopathological features, for inferior RFS and OS. No 33727578 hsa_circ_0076251 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR Our data demonstrated that the hsa_circ_0028502 and hsa_circ_0076251 levels were considerably lower in HCC tissues than in adjacent paracancerous tissues (P < .001). Further study revealed that hsa_circ_0028502 expression levels were related to tumor node metastasis (TNM) stage (P = .015) and that hsa_circ_0076251 expression levels were related to Barcelona Clinic Liver Cancer (BCLC) stage (P = .038), comorbidity with type 2 diabetes mellitus (P = .023) and the presence of serum HbsAg (P = .044). No 31595711 hsa_circ_0025624 CircRNA Homo sapiens Carcinoma, Hepatocellular 233 frozen tumour specimens and paired para-tumour normal background liver tissues Expression [lower expressed] qRT-PCR We found using high-throughput sequencing that seven candidate circRNAs (hsa_circ_0041150, hsa_circ_0025624, hsa_circ_0001020, hsa_circ_0028129, hsa_circ_0008558, hsa_circ_0036683, hsa_circ_0058087) were downregulated in HCC. No 33727578 hsa_circ_0003998 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and HCC cell lines,blood Expression[highly expressed] qRT-PCR Hsa_circ_0003998 was upregulated in HCC tissues (P<0.001) and HCC cell lines (HepG2, HuH7, MHCC97H) (P<0.001). The plasma level of hsa_circ_0003998 in HCC patients was significantly higher than those in hepatitis B patients (P<0.001) and healthy controls (P<0.001). In addition, upregulation of hsa_circ_0003998 level was associated with higher serum alpha-fetoprotien (AFP) level (P=0.003), larger tumor diameter (P=0.009), lower differentiation level (P=0.023) and microvascular invasion (P=0.028). No 31410028 hsa_circ_0067934 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues From the results, qRT-PCR analysis revealed that circ_0067934 was significantly up-regulated in HCC tissues compared with adjacent non-tumor tissues.[] qRT-PCR From the results, qRT-PCR analysis revealed that circ_0067934 was significantly up-regulated in HCC tissues compared with adjacent non-tumor tissues. Moreover, circ_0067934 positively correlated with tumor size (P=0.0025), TNM stage (P<0.0001) and microvascular invasion (P<0.0001). No 33334787 hsa_circ_0001955 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014130). No 33230434 hsa_circ_0001535 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014130). No 33230434 hsa_circ_0061395 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014130). No 33230434 hsa_circ_0000502 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014130). No 33230434 hsa_circ_0066659 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014130). No 33230434 hsa_circ_0046366 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014130). No 33230434 hsa_circ_0003418 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014130). No 33230434 hsa_circ_0026134 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014130). No 33230434 hsa_circ_0005692 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014130). No 33230434 hsa_circ_0014130 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray Quantitative real-time PCR was used to determine the level-10 circRNAs selected from the top five upregulated (hsa_circ_0001955, hsa_circ_0001535, hsa_circ_0061395, hsa_circ_0000502, and hsa_circ_0066659) and top five downregulated circRNAs (hsa_circ_0046366, hsa_circ_0003418, hsa_circ_0026134, hsa_circ_0005692, and hsa_circ_0014130). No 33230434 circUHRF1 CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR Here, we report that the expression of circUHRF1 is higher in human HCC tissues than in matched adjacent nontumor tissues. No 32593303 circAKT3 CircRNA Homo sapiens Carcinoma, Hepatocellular exosomal Expression[highly expressed] qRT-PCR The expression of exosomal circAKT3 in HCC patients was significantly increased compared with healthy subjects. Patients with high circulating exosomal circAKT3 had higher tumor recurrence rates (hazard risk (HR), 3.14; 95% confidence interval (CI), 1.29-6.21, P = 0.012) and higher mortality (HR, 1.89; 95% CI, 1.04-3.01), P = 0.048). Survival analysis showed that the overall survival rate and recurrence-free survival rate of patients with high exosomal circAKT3 were lower than the patients had low exosomal circAKT3. No 32561093 hsa_circ_0001095 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR Compared with normal samples, seven up-regulated and five down-regulated circRNAs were detected in the HCC blood samples. The DECs and the corresponding FC and p-values are listed in Table 2. No 32536814 hsa_circ_0005871 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR Compared with normal samples, seven up-regulated and five down-regulated circRNAs were detected in the HCC blood samples. The DECs and the corresponding FC and p-values are listed in Table 3. No 32536814 hsa_circ_0004001 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR Compared with normal samples, seven up-regulated and five down-regulated circRNAs were detected in the HCC blood samples. The DECs and the corresponding FC and p-values are listed in Table 4. No 32536814 hsa_circ_0060849 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR Compared with normal samples, seven up-regulated and five down-regulated circRNAs were detected in the HCC blood samples. The DECs and the corresponding FC and p-values are listed in Table 5. No 32536814 hsa_circ_0007067 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR Compared with normal samples, seven up-regulated and five down-regulated circRNAs were detected in the HCC blood samples. The DECs and the corresponding FC and p-values are listed in Table 6. No 32536814 hsa_circ_0075792 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR Compared with normal samples, seven up-regulated and five down-regulated circRNAs were detected in the HCC blood samples. The DECs and the corresponding FC and p-values are listed in Table 7. No 32536814 hsa_circ_0004123 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR Compared with normal samples, seven up-regulated and five down-regulated circRNAs were detected in the HCC blood samples. The DECs and the corresponding FC and p-values are listed in Table 8. No 32536814 hsa_circ_0002157 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[lower expressed] qRT-PCR Compared with normal samples, seven up-regulated and five down-regulated circRNAs were detected in the HCC blood samples. The DECs and the corresponding FC and p-values are listed in Table 9. No 32536814 hsa_circ_0007974 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[lower expressed] qRT-PCR Compared with normal samples, seven up-regulated and five down-regulated circRNAs were detected in the HCC blood samples. The DECs and the corresponding FC and p-values are listed in Table 10. No 32536814 hsa_circ_0003965 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[lower expressed] qRT-PCR Compared with normal samples, seven up-regulated and five down-regulated circRNAs were detected in the HCC blood samples. The DECs and the corresponding FC and p-values are listed in Table 11. No 32536814 hsa_circ_0003195 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[lower expressed] qRT-PCR Compared with normal samples, seven up-regulated and five down-regulated circRNAs were detected in the HCC blood samples. The DECs and the corresponding FC and p-values are listed in Table 12. No 32536814 hsa_circ_0037002 CircRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[lower expressed] qRT-PCR Compared with normal samples, seven up-regulated and five down-regulated circRNAs were detected in the HCC blood samples. The DECs and the corresponding FC and p-values are listed in Table 13. No 32536814 circMET CircRNA Homo sapiens Carcinoma, Hepatocellular HCC tumors Expression[highly expressed] qRT-PCR circMET (hsa_circ_0082002) was overexpressed in HCC tumors, and circMET expression was associated with survival and recurrence in HCC patients. circMET (hsa_circ_0082002) was overexpressed in HCC tumors, and circMET expression was associated with survival and recurrence in HCC patients. No 32430013 hsa_circ_0016788 CircRNA Homo sapiens Carcinoma, Hepatocellular tumor tissue Expression[highly expressed] qRT-PCR Circ_0016788 was elevated in tumor tissue compared with adjacent tissue, and it had an excellent value in distinguishing tumor tissue from adjacent tissue (area under the curve: 0.913; 95% confidence interval: 0.885-0.941). Furthermore, circ_0016788 correlated to higher performance status score, larger tumor size, increased Barcelona clinic liver cancer (BCLC) stage, abnormal aspartate aminotransferase, abnormal alpha-fetoprotein, and abnormal carbohydrate antigen 199 levels. Circ_0016788 was elevated in tumor tissue compared with adjacent tissue, and it had an excellent value in distinguishing tumor tissue from adjacent tissue (area under the curve: 0.913; 95% confidence interval: 0.885-0.941). Furthermore, circ_0016788 correlated to higher performance status score, larger tumor size, increased Barcelona clinic liver cancer (BCLC) stage, abnormal aspartate aminotransferase, abnormal alpha-fetoprotein, and abnormal carbohydrate antigen 199 levels.Moreover, by Kaplan-Meier curve and log-rank test, circ_0016788 high expression correlated with shorter overall survival (OS). No 32319701 hsa_circ_0041150 CircRNA Homo sapiens Carcinoma, Hepatocellular 233 frozen tumour specimens and paired para-tumour normal background liver tissues Expression [lower expressed] qRT-PCR We found using high-throughput sequencing that seven candidate circRNAs (hsa_circ_0041150, hsa_circ_0025624, hsa_circ_0001020, hsa_circ_0028129, hsa_circ_0008558, hsa_circ_0036683, hsa_circ_0058087) were downregulated in HCC. No 33727578 hsa_circ_004452 CircRNA Homo sapiens Colonic Neoplasms colon tissues Expression[lower expressed] qRT-PCR//RNA-seq As displayed in Figure 9, circ_022743 was significantly downregulated in both ES and LS colon tumor tissues compared with those in normal tissues, while circ_052666 was markedly upregulated in both ES and LS colon tumor tissues. Moreover, circ_004452 was only downregulated in LS colon tumor tissues in comparison with that in normal colon tissues. No 32799546 hsa_circ_022743 CircRNA Homo sapiens Colonic Neoplasms colon tissues Expression[lower expressed] qRT-PCR//RNA-seq As displayed in Figure 9, circ_022743 was significantly downregulated in both ES and LS colon tumor tissues compared with those in normal tissues, while circ_052666 was markedly upregulated in both ES and LS colon tumor tissues. Moreover, circ_004452 was only downregulated in LS colon tumor tissues in comparison with that in normal colon tissues. No 32799546 hsa_circ_001747 CircRNA Homo sapiens Urinary Bladder Neoplasms cell lines(CCC-HB-2,SW780, 5637, T24, J82 and RT6) Expression[highly expressed] qRT-PCR Further qPCR results confirmed that has_circRNA_000542, has_circRNA_403658, has_circRNA_001747, has_circRNA_103868, and has_circRNA_030448 were significantly increased in hypoxia-cultured 5639 cells compared with normal-cultured cells No 31814891 hsa_circ_0015320 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0022179 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0062823 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0084789 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0049270 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0051240 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0073324 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0024888 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0040831 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0081545 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0068513 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0061264 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0042104 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 circSLC7A5 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues,cell lines Expression[highly expressed] qRT-PCR//RNA-seq//Microarray Characteristics of circRNAs including length, types, and the possibility of binding to proteins are analyzed. Candidate tumor-related circRNAs are then quantitated in ESCC tissues, plasmas and cell lines. ESCC tissues can secret circRNAs into plasma and patients with high plasma circ-SLC7A5 are associated with high TNM stage, tending to have shorter overall survival than those with high levels. In the current study, circRNAs expression profiles are screened in ESCC, using plasma samples from 10 ESCC patients, including different TNM stages and 5 normal controls. Characteristics of circRNAs including length, types, and the possibility of binding to proteins are analyzed. Candidate tumor-related circRNAs are then quantitated in ESCC tissues, plasmas and cell lines. ESCC tissues can secret circRNAs into plasma and patients with high plasma circ-SLC7A5 are associated with high TNM stage, tending to have shorter overall survival than those with high levels. No 31726270 circGSK3β CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Regulation[β-catenin signaling] PCR//Microarray We demonstrated that upregulated expression of circGSK3β was positively associated with advanced clinical stage and poor outcome in patients with ESCC. We further revealed that circGSK3β promoted ESCC cell migration and invasion via direct interaction with GSK3β and inhibiting GSK3β activity, providing a novel mechanism of circRNA in cancer progression. Importantly, we identified that circGSK3β expression in plasma was a biomarker for detection of ESCC and early stage of ESCC with the area under curve (AUC) of 0.782 and 0.793, respectively. No 31722716 hsa_circ_0071662 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Expression(lower expressed) qRT-PCR Circ_0071662 level was decreased in ESCC, but not in GERN and EU compared to the controls and in ESCC tissues compared to the non-tumor tissues. Plasma circ_0071662 was closely correlated with patients' tumor size but not with other clinical features. Decreased plasma circ_0071662 levels separated ESCC patients from GERN patients, EU patients, and healthy controls. Low plasma circ_0071662 levels were closely correlated with worse survival outcomes of ESCC patients. No 35002298 hsa_circ_0007541 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma 73 paired ESCC tumor and normal tissues Regulation qRT-PCR//RNA-seq Through bioinformatics analysis, we screened a circRNA signature including four circRNAs (hsa_circ_0000005, hsa_circ_0007541, hsa_circ_0008199, hsa_circ_0077536) which can classify the ESCC patients into two groups with significantly different survival (log rank P < 0.001), and found its predictive performance was better than that of the TNM stage(0.84 vs. 0.66; 0.65 vs. 0.62). Through qPCR and FISH experiment, we validated the existence of the screened circRNAs and the predictive power of the circRNA signature. No 33663506 hsa_circ_0008199 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma 73 paired ESCC tumor and normal tissues Regulation qRT-PCR//RNA-seq Through bioinformatics analysis, we screened a circRNA signature including four circRNAs (hsa_circ_0000005, hsa_circ_0007541, hsa_circ_0008199, hsa_circ_0077536) which can classify the ESCC patients into two groups with significantly different survival (log rank P < 0.001), and found its predictive performance was better than that of the TNM stage(0.84 vs. 0.66; 0.65 vs. 0.62). Through qPCR and FISH experiment, we validated the existence of the screened circRNAs and the predictive power of the circRNA signature. No 33663506 hsa_circ_0077536 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma 73 paired ESCC tumor and normal tissues Regulation qRT-PCR//RNA-seq Through bioinformatics analysis, we screened a circRNA signature including four circRNAs (hsa_circ_0000005, hsa_circ_0007541, hsa_circ_0008199, hsa_circ_0077536) which can classify the ESCC patients into two groups with significantly different survival (log rank P < 0.001), and found its predictive performance was better than that of the TNM stage(0.84 vs. 0.66; 0.65 vs. 0.62). Through qPCR and FISH experiment, we validated the existence of the screened circRNAs and the predictive power of the circRNA signature. No 33663506 hsa_circ_0000005 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma 73 paired ESCC tumor and normal tissues Regulation qRT-PCR//RNA-seq Through bioinformatics analysis, we screened a circRNA signature including four circRNAs (hsa_circ_0000005, hsa_circ_0007541, hsa_circ_0008199, hsa_circ_0077536) which can classify the ESCC patients into two groups with significantly different survival (log rank P < 0.001), and found its predictive performance was better than that of the TNM stage(0.84 vs. 0.66; 0.65 vs. 0.62). Through qPCR and FISH experiment, we validated the existence of the screened circRNAs and the predictive power of the circRNA signature. No 33663506 hsa_circ_0026611 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma exosomal Expression(highly expressed) qRT-PCR//Western Blot The expression levels of serum exosomal has_circ_0026611 in ESCC with lymph node metastasis were significantly higher than those in ESCC without lymph node metastasis (P =0.001). In addition, serum exosomal hsa_circ_0026611 expression could be used as a significant parameter to discriminate between non-lymph node-metastatic and lymph node-metastatic ESCC with an area under curve (AUC) of 0.724 (95% CI: 0.604~0.865). No 33403048 circLONP2 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues and cells Interaction(MiR-27b-3p-ZEB1 Axis) RNA Pull-Down//Western Blot//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay We found that circLONP2 was upregulated in human ESCC and predicts poor overall survival (OS) and disease-free survival (DFS). CircLONP2 promotes ESCC aggressiveness by directly interacting with miR-27b-3p, thus upregulating the expression levels of its target gene ZEB1 by suppressing miR-27b-3p activity. Therefore, we demonstrated that circLONP2/miR-27b-3p/ZEB1 axis promotes ESCC metastasis via regulating epithelial-to-mesenchymal transition (EMT)-related proteins. We found that circLONP2 was upregulated in human ESCC and predicts poor overall survival (OS) and disease-free survival (DFS). No 35865464 circHIPK3 CircRNA Homo sapiens Lung Neoplasms lung cancer tissues Regulation[circHIPK3-miR-124 pathway] qRT-PCR At last, we show that circHIPK3 levels are upregulated in human lung cancer tissues, correlated with miR-124 downregulation. These observations indicate a possible novel therapeutic strategy involving circHIPK3-miR-124 pathway against lung cancer. No 30352682 circNOL10 CircRNA Homo sapiens Lung Neoplasms Lung Cancer tissues,cell lines Interaction[Promoting SCLM1] ChIP-seq " circNOL10 expression levels were significantly decreased in all six lung cancer cell lines, and were lowest in H460 and A549 cells (decreased by 13‐fold and 8‐fold, respectively) (Figure ​(Figure1B).1B). circNOL10 expression was also detected in 61 pairs of cancerous and paracancerous lung tissue samples, and levels were shown to be significantly lower in the cancer tissues in 41 of the 61 paired samples (Figure S1C, Supporting Information). The decrease in circNOL10 expression in lung cancer compared with control tissues was statistically significant (Figure ​(Figure1C).1C). circNOL10 expression levels were also significantly lower in poorly and intermediately differentiated lung cancers, and the decreases in lung squamous cell carcinoma and lung adenocarcinoma tissues were both significant (Figure ​(Figure11D,E). circNOL10 promotes the expression of transcription factor sex comb on midleg-like 1 (SCML1) by inhibiting transcription factor ubiquitination and thus also affects regulation of the humanin (HN) polypeptide family by SCML1. " No 30693177 circAKT3 CircRNA Homo sapiens Lung Neoplasms lung cancer tissues and cells Expression[highly expressed] qRT-PCR The levels of circAKT3 and STAT3 were upregulated, miR-516b-5p was downregulation in lung cancer tissues and cells. No 32170433 hsa_circ_0002490 CircRNA Homo sapiens Lung Neoplasms LC tissues Expression(lower expressed) qRT-PCR The expression levels of has_circ_0002490, has_circ_0087357, has_circ_0004891, has_circ_0074368, and has_circ_0000896 were downregulated in LC tissues compared with adjacent normal lung tissues. The lower levels of has_circ_0002490, has_circ_0087357, has_circ_0004891, and has_circ_0000896 were significantly correlated with advanced disease stages. No 35089074 hsa_circ_0087357 CircRNA Homo sapiens Lung Neoplasms LC tissues Expression(lower expressed) qRT-PCR The expression levels of has_circ_0002490, has_circ_0087357, has_circ_0004891, has_circ_0074368, and has_circ_0000896 were downregulated in LC tissues compared with adjacent normal lung tissues. The lower levels of has_circ_0002490, has_circ_0087357, has_circ_0004891, and has_circ_0000896 were significantly correlated with advanced disease stages. No 35089074 hsa_circ_0074368 CircRNA Homo sapiens Lung Neoplasms LC tissues Expression(lower expressed) qRT-PCR The expression levels of has_circ_0002490, has_circ_0087357, has_circ_0004891, has_circ_0074368, and has_circ_0000896 were downregulated in LC tissues compared with adjacent normal lung tissues. The lower levels of has_circ_0002490, has_circ_0087357, has_circ_0004891, and has_circ_0000896 were significantly correlated with advanced disease stages. No 35089074 hsa_circ_0004891 CircRNA Homo sapiens Lung Neoplasms LC tissues Expression(lower expressed) qRT-PCR The expression levels of has_circ_0002490, has_circ_0087357, has_circ_0004891, has_circ_0074368, and has_circ_0000896 were downregulated in LC tissues compared with adjacent normal lung tissues. The lower levels of has_circ_0002490, has_circ_0087357, has_circ_0004891, and has_circ_0000896 were significantly correlated with advanced disease stages. No 35089074 hsa_circ_0077156 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0057693 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 circASPHD1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 hsa_circ_0038976 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0077837 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Regulation(PTEN methylation) qRT-PCR//Western Blot Our data showed that hsa_circ_0077837 was upregulated in NSCLC and predicted poor survival. In NSCLC cells, hsa_circ_0077837 overexpression decreased PTEN expression, increased PTEN gene methylation, and reduced HCC827 cell apoptosis via PTEN. Overall, hsa_circ_0077837 is upregulated in NSCLC and downregulates PTEN by increasing its gene methylation to suppress cell apoptosis. Our data showed that hsa_circ_0077837 was upregulated in NSCLC and predicted poor survival. . Besides, hsa_circ_0077837 expression level was higher in 36 advanced cases (stage III and IV) than in 28 early-stage cases (stage I and II). No 35246018 hsa_circ_0069313 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung serum samples Expression(lower expressed) qRT-PCR//Western Blot The levels of hsa_circ_0069313 in serum exosomes were statistically lower than those in the matched serum samples. The levels of serum and serum exosomal hsa_circ_0069313 were notably elevated in the NSCLC group compared to the healthy, pneumonia and benign lung tumor groups. Furthermore, serum and serum exosomal hsa_circ_0069313 could differ benign lung tumor and NSCLC with AUC values of 0.803 and 0.749, respectively. Intriguingly, the higher levels of serum exosomal hsa_circ_0069313 were associated with stage III-IV, lymph node metastasis and distant metastasis of NSCLC. No 35077682 hsa_circ_0003497 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells Interaction(hsa_circ_0003497-miR-197-3p-CTNND1-NSCLC axis ) qRT-PCR hsa_circ_0003497 was down-regulated in NSCLC and played an inhibitory role in tumorigenesis. In contrast, miR-197-3p was up-regulated in NSCLC. hsa_circ_0003497 directly interacts with miR-197-3p and releases a target gene of miR-197-3p termed CTNND1 (a known tumor suppressor gene). Evolutionary analysis reveals fast evolution of this hsa_circ_0003497-miR-197-3p-CTNND1-NSCLC axis in mammals. No 36036266 circFOXP1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung serum of patients with NSCLC Interaction(hsa-miR-370-3p and hsa-miR-18a-5p) qRT-PCR By performing qRT-PCR assay, we identified that circFOXP1 (hsa_circ_0008234) and conventional tumor markers (carcinoembryonic antigen (CEA) and cytokeratin fragment 21-1 (CYFRA21-1)) were all significantly overexpressed in the serum of patients with NSCLC when compared with healthy controls (P < 0.05). Mechanistically, circFOXP1 might target hsa-miR-370-3p and hsa-miR-18a-5p, and be involved in vascular endothelial growth factor signaling pathways to regulate proliferative and metastasis processes. No 35072545 circFOXK2 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and CD8+ T cells Interaction(miR-485-5p/PD-L1 axis) CCK8//qRT-PCR//Western Blot CircFOXK2 and PD-L1 levels were augmented in NSCLC. CircFOXK2 targeted miR-485-5p, which could bind to PD-L1. CircFOXK2 served a key role in NSCLC tumorigenesis and cytotoxicity of CD8+ T cells. MiR-485-5p inhibition or PD-L1 overexpression abolished the inhibitory effects of circFOXK2 lack on NSCLC tumorigenesis and cytotoxicity of CD8+ T cells. No 35324518 hsa_circ_0024108 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0013360 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0025579 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0015605 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0024103 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0020377 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0044552 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0058837 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0020208 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0085289 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0025583 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0062558 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0051751 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0057371 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0030018 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0010170 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0091540 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0010434 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0072121 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0026385 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0049613 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0032709 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0083800 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0076323 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and para-cancer tissues Expression[Expression[lower expressed]-expression] qRT-PCR//circRNA-seq A total of 3, 288 circRNAs were identified (FC>2 or <0.5., P<0.0.1). Of these circRNAs, 2, 139 were Expression[Expression[up-expression]-expression]-regulated, and 1, 149 were Expression[down-expression]-regulated. Top 40 differently expressed circRNAs were listed in Table 1. No 30468655 hsa_circ_0000896 CircRNA Homo sapiens Lung Neoplasms LC tissues Expression(lower expressed) qRT-PCR The expression levels of has_circ_0002490, has_circ_0087357, has_circ_0004891, has_circ_0074368, and has_circ_0000896 were downregulated in LC tissues compared with adjacent normal lung tissues. The lower levels of has_circ_0002490, has_circ_0087357, has_circ_0004891, and has_circ_0000896 were significantly correlated with advanced disease stages. No 35089074 circPVT1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circCDYL CircRNA Homo sapiens Colonic Neoplasms colon cancer tissues Expression[lower expressed] CCK8//PCR//Western Blot We found circCDYL was generally decreased while miR-150-5p was increased in colon cancer tissues in parallel with the para-carcinoma tissues. No 31829306 circCCT3 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[miR-613/WNT3 or miR-613/VEGFA] Transwell Assay//qRT-PCR//Luciferase Report Assay//Western Blot We carried out bioinformatic analysis to show higher expression of circCCT3 in human clinical CRC tumors.In conclusion, we propose that circCCT3 contributes to CRC metastasis via miR-613/WNT3 or miR-613/VEGFA, promoting the development of therapeutical approaches for treating CRC. Low level of circCCT3 was closely associated with higher disease-free survival of CRC patients. Moreover, we found that circCCT3 was linked to advanced stage of CRC. No 31859543 hsa_circ_0067163 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] circRNA-seq We have identified six potential key circRNAs (circPIEZO1-3, hsa_circ_0067163, hsa_circ_0140188, hsa_circ_0002632, hsa_circ_0001998 and hsa_circ_0023990) associated with CRC, which play important roles in carcinogenesis as ceRNA for regulation of miRNA-mRNA network. In the subsequent KEGG analysis, several CRC-related pathways were found. No 31579577 hsa_circ_0140188 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] circRNA-seq We have identified six potential key circRNAs (circPIEZO1-3, hsa_circ_0067163, hsa_circ_0140188, hsa_circ_0002632, hsa_circ_0001998 and hsa_circ_0023990) associated with CRC, which play important roles in carcinogenesis as ceRNA for regulation of miRNA-mRNA network. In the subsequent KEGG analysis, several CRC-related pathways were found. No 31579577 hsa_circ_0002632 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] circRNA-seq We have identified six potential key circRNAs (circPIEZO1-3, hsa_circ_0067163, hsa_circ_0140188, hsa_circ_0002632, hsa_circ_0001998 and hsa_circ_0023990) associated with CRC, which play important roles in carcinogenesis as ceRNA for regulation of miRNA-mRNA network. In the subsequent KEGG analysis, several CRC-related pathways were found. No 31579577 hsa_circ_0001998 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] circRNA-seq We have identified six potential key circRNAs (circPIEZO1-3, hsa_circ_0067163, hsa_circ_0140188, hsa_circ_0002632, hsa_circ_0001998 and hsa_circ_0023990) associated with CRC, which play important roles in carcinogenesis as ceRNA for regulation of miRNA-mRNA network. In the subsequent KEGG analysis, several CRC-related pathways were found. No 31579577 hsa_circ_0023990 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] circRNA-seq We have identified six potential key circRNAs (circPIEZO1-3, hsa_circ_0067163, hsa_circ_0140188, hsa_circ_0002632, hsa_circ_0001998 and hsa_circ_0023990) associated with CRC, which play important roles in carcinogenesis as ceRNA for regulation of miRNA-mRNA network. In the subsequent KEGG analysis, several CRC-related pathways were found. No 31579577 hsa_circ_000425 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines Expression[lower expressed] qRT-PCR A significant downregulation of hsa_circ_000425 was observed in both CRC tissues and cell lines. In addition, this downregulation was significantly associated with differentiation and lymphatic metastasis. The area under the ROC curve of hsa_circ_000425 was 0.839 (P < 0.001). hsa_circ_000425 may have a role in the pathogenesis of CRC and might act as a potential biomarker for the diagnosis and treatment of CRC; although further molecular studies must be performed in this regard. No 33688484 circFMN2 CircRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR The results verified that circ-FMN2, circ-LMNB1, and circ-ZNF609 were significantly elevated in serum samples of CRC patients compared with healthy controls (p < 0.01). Increased circ-FMN2, circ-LMNB1, and circ-ZNF609 expressions were markedly positively correlated with histological grade (p < 0.0001, p = 0.0014, p = 0.0303), lymph nodes metastasis (p < 0.0001, p < 0.0001, p = 0.0093), and TNM stage (p = 0.0055, p = 0.0110, p < 0.000). Meanwhile, the ROC curve analysis verified the diagnostic accuracy of circ-FMN2, circ-LMNB1, and circ-ZNF609 with AUC of 0.9153 (95% CI = 0.8707 ~ 0.9599), 0.9627 (95% CI = 0.9351 ~ 0.9903), and 0.8711 (95% CI = 0.8151 ~ 0.9270), respectively. Furthermore, the CRC patients with high circ-FMN2, circ-LMNB1, and circ-ZNF609 had significantly worse outcomes than those with low expression (p = 0.0267, p = 0.0145, p = 0.0194). No 33337836 circLMNB1 CircRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR The results verified that circ-FMN2, circ-LMNB1, and circ-ZNF609 were significantly elevated in serum samples of CRC patients compared with healthy controls (p < 0.01). Increased circ-FMN2, circ-LMNB1, and circ-ZNF609 expressions were markedly positively correlated with histological grade (p < 0.0001, p = 0.0014, p = 0.0303), lymph nodes metastasis (p < 0.0001, p < 0.0001, p = 0.0093), and TNM stage (p = 0.0055, p = 0.0110, p < 0.000). Meanwhile, the ROC curve analysis verified the diagnostic accuracy of circ-FMN2, circ-LMNB1, and circ-ZNF609 with AUC of 0.9153 (95% CI = 0.8707 ~ 0.9599), 0.9627 (95% CI = 0.9351 ~ 0.9903), and 0.8711 (95% CI = 0.8151 ~ 0.9270), respectively. Furthermore, the CRC patients with high circ-FMN2, circ-LMNB1, and circ-ZNF609 had significantly worse outcomes than those with low expression (p = 0.0267, p = 0.0145, p = 0.0194). No 33337836 circZNF609 CircRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR The results verified that circ-FMN2, circ-LMNB1, and circ-ZNF609 were significantly elevated in serum samples of CRC patients compared with healthy controls (p < 0.01). Increased circ-FMN2, circ-LMNB1, and circ-ZNF609 expressions were markedly positively correlated with histological grade (p < 0.0001, p = 0.0014, p = 0.0303), lymph nodes metastasis (p < 0.0001, p < 0.0001, p = 0.0093), and TNM stage (p = 0.0055, p = 0.0110, p < 0.000). Meanwhile, the ROC curve analysis verified the diagnostic accuracy of circ-FMN2, circ-LMNB1, and circ-ZNF609 with AUC of 0.9153 (95% CI = 0.8707 ~ 0.9599), 0.9627 (95% CI = 0.9351 ~ 0.9903), and 0.8711 (95% CI = 0.8151 ~ 0.9270), respectively. Furthermore, the CRC patients with high circ-FMN2, circ-LMNB1, and circ-ZNF609 had significantly worse outcomes than those with low expression (p = 0.0267, p = 0.0145, p = 0.0194). No 33337836 hsa_circ_0001900 CircRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR We ultimately determined that hsa_circ_0001900, hsa_circ_0001178, and hsa_circ_0005927 were upregulated in the plasma of CRC patients relative to healthy controls and were correlated with clinicopathological findings in these patients. No 33312376 hsa_circ_0001178 CircRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR We ultimately determined that hsa_circ_0001900, hsa_circ_0001178, and hsa_circ_0005927 were upregulated in the plasma of CRC patients relative to healthy controls and were correlated with clinicopathological findings in these patients. No 33312376 hsa_circ_0005927 CircRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR We ultimately determined that hsa_circ_0001900, hsa_circ_0001178, and hsa_circ_0005927 were upregulated in the plasma of CRC patients relative to healthy controls and were correlated with clinicopathological findings in these patients. No 33312376 hsa_circ_0128846 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues regulation[Hippo/YAP signalling] Western Blot//Wound Healing Assay//Invasion Assay//Migration Assay//Flow Cytometry//qRT-PCR//RIP//EdU Staining//Transwell Assay In colorectal cancer tissues, circ_0128846 and AJUBA were both significantly up-regulated, while miR-1184 was significantly down-regulated compared with healthy tissues.This study revealed that hsa_circ_0128846 contributed to the development of CRC by decreasing the expression of miR-1184, thereby increasing AJUBA expression and inactivating Hippo/YAP signalling. No 32681581 hsa_circ_0002320 CircRNA Homo sapiens Colorectal Neoplasms Plasma samples, CRC tissues Expression[lower expressed] qRT-PCR Expression levels of hsa_circ_0002320 were significantly decreased in CRC plasma (P < .05). The expression level of hsa_circ_0002320 was significantly correlated with OS time (P < .05). Higher hsa_circ_0002320 reflected significantly greater OS; the HR of high hsa_circ_0002320 was 0.161 (95% CI, 0.066-0.393; P = .000). The area under the ROC curve of hsa_circ_0002320 in CRC was 0.823, which was higher than for the carcinoembryogenic antigen (area under the curve = 0.764). Kaplan-Meier analysis showed that CRC patients with low expression of hsa_circ_0002320 exhibited poorer OS times than those with high expression. No 32664176 hsa_circ_100876 CircRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues interaction[targeting microRNA-516b ] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Our data showed that circRNA_100876 was highly expressed in CRC tumor tissues, and the high expression gtransition (EMT)-related proteins. Furthermore, we found that the addition of miR-516b reversed the anti-tumor effect induced by the downregulation of circRNA_100876. No 32564659 circDDX17 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Expression[lower expressed] CCK8//qRT-PCR//Western Blot//Transwell Assay CircDDX17 and KANK1 were down-regulated, while miR-31-5p was upregulated in CRC tissues and cells. No 32141542 hsa_circ_0006282 CircRNA Homo sapiens Colorectal Neoplasms tumoral, adjacent normal tissue, and plasma samples from 100 colorectal cancer (CRC) patients, 25 postoperative CRC patients, 28 colitis patients, and 108 healthy donors Expression [highly expressed] qRT-PCR The hsa_circ_0006282 was the highest upregulated differentially expressed circRNA. Expression evaluation of this circRNA on different samples showed upregulation in CRC tissues (p < 0.0001) and plasma samples of CRC patients in comparison to healthy controls (p < 0.0001), while the area under the curve (AUC) was 0.831 (95% CI: 0.779-0.883). Expression of hsa_circ_0006282 in CRC patients decreased to normal after surgery (p < 0.0001). No 34860442 hsa_circ_001787 CircRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression [lower expressed] qRT-PCR We detected that hsa_circ_001787 expression level was significantly down expressed in CRC tissue versus paired CRC histological normal tissue. The expression level of hsa_circ_001787 was significantly associated with pathological factors such as tumor grade and the primary site of the tumor. No 34759742 hsa_circ_0000212 CircRNA Homo sapiens Colorectal Neoplasms Interaction(miR‑491) RIP//Luciferase Report Assay A novel circular (circ)RNA, hsa_circ_0000212, was found to sponge miR‑491 based on bioinformatics analysis. No 33649850 hsa_circ_0001821 CircRNA Homo sapiens Colorectal Neoplasms 467 plasma samples, including samples from 80 healthy controls Expression(highly expressed) qRT-PCR Plasma hsa_circ_0001821 was increased in CRC patients, and high hsa_circ_0001821 expression predicted advanced stage and unfavorable in overall survival.. In addition, this study showed the upregulation of hsa_circ_0001821 in plasma of lung cancer and hepatocellular carcinoma (HCC). Plasma hsa_circ_0001821 was increased in CRC patients, and high hsa_circ_0001821 expression predicted advanced stage and unfavorable in overall survival. No 34523755 hsa_circ_0009910 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and adjacent specimens Interaction(miR-145 and PEAK1) qRT-PCR Circ0009910 and PEAK1 were significantly upregulated, while miR-145-5p was decreased in CRC samples compared with adjacent tissues (p < 0.05). Moreover, statistically significant correlations were observed between expression levels of circ0009910, miR-145-5p, and PEAK1. We also reported considerable correlations between circ0009910 expression and clinicopathological parameters including sex and perineural invasion. We also reported considerable correlations between circ0009910 expression and clinicopathological parameters including sex and perineural invasion. Finally, ROC curve analysis showed circ0009910 level as a discriminative biomarker for CRC. No 34479583 circPVT1 CircRNA Homo sapiens Colorectal Neoplasms CRC patients' plasma Expression(highly expressed) qRT-PCR Compared to the healthy controls, circ_PVT1 and circ_001569 expressions were significantly upregulated in the CRC patients' plasma, in a significant fold change of 1.997 and 2.738. Meanwhile, circ_PVT1 and circ_001569 expressions were correlated with tumor node metastasis (TNM) stage, tumor size, and lymph node metastasis. The area under the curves (AUC) of circ_PVT1 and circ_001569 were 0.8389 (95% CI, 0.7889-0.8890) and 0.9016 (95%CI, 0.8588-0.9444). Higher circ_PVT1 and circ_001569 expressions correlated to CRC patients' poor prognosis more than those with lower expressions. No 33653781 hsa_circ_001569 CircRNA Homo sapiens Colorectal Neoplasms CRC patients' plasma Expression(highly expressed) qRT-PCR Compared to the healthy controls, circ_PVT1 and circ_001569 expressions were significantly upregulated in the CRC patients' plasma, in a significant fold change of 1.997 and 2.738. Meanwhile, circ_PVT1 and circ_001569 expressions were correlated with tumor node metastasis (TNM) stage, tumor size, and lymph node metastasis. The area under the curves (AUC) of circ_PVT1 and circ_001569 were 0.8389 (95% CI, 0.7889-0.8890) and 0.9016 (95%CI, 0.8588-0.9444). Higher circ_PVT1 and circ_001569 expressions correlated to CRC patients' poor prognosis more than those with lower expressions. No 33653781 hsa_circ_001978 CircRNA Homo sapiens Colorectal Neoplasms plasma samples of CRC patients Expression(highly expressed) qRT-PCR Eight circRNAs (hsa_circ_104885, hsa_circ_100185, hsa_circ_103171, hsa_circ_001978, hsa_circ_105039, hsa_circ_103627, hsa_circ_101717, and hsa_circ_104192) were obtained as candidate circRNAs with upregulation in CRC comparing with both CRA and healthy control. Through detecting the plasma expression levels of eight candidate targets, we identified three circRNA (hsa_circ_001978, hsa_circ_105039, and hsa_circ_103627) with increased level which were consistent with the microarray results in training set. Further validation found the circRNA panel was consistent with training set. The ROC curve also revealed a high diagnostic ability of hsa_circ_001978, hsa_circ_105039, and hsa_circ_103627 in predicted the CRC from CRA patients (AUC = 0.966) as well as healthy controls (AUC = 0.969). No 35421275 hsa_circ_105039 CircRNA Homo sapiens Colorectal Neoplasms plasma samples of CRC patients Expression(highly expressed) qRT-PCR Eight circRNAs (hsa_circ_104885, hsa_circ_100185, hsa_circ_103171, hsa_circ_001978, hsa_circ_105039, hsa_circ_103627, hsa_circ_101717, and hsa_circ_104192) were obtained as candidate circRNAs with upregulation in CRC comparing with both CRA and healthy control. Through detecting the plasma expression levels of eight candidate targets, we identified three circRNA (hsa_circ_001978, hsa_circ_105039, and hsa_circ_103627) with increased level which were consistent with the microarray results in training set. Further validation found the circRNA panel was consistent with training set. The ROC curve also revealed a high diagnostic ability of hsa_circ_001978, hsa_circ_105039, and hsa_circ_103627 in predicted the CRC from CRA patients (AUC = 0.966) as well as healthy controls (AUC = 0.969). No 35421275 hsa_circ_103627 CircRNA Homo sapiens Colorectal Neoplasms plasma samples of CRC patients Expression(highly expressed) qRT-PCR Eight circRNAs (hsa_circ_104885, hsa_circ_100185, hsa_circ_103171, hsa_circ_001978, hsa_circ_105039, hsa_circ_103627, hsa_circ_101717, and hsa_circ_104192) were obtained as candidate circRNAs with upregulation in CRC comparing with both CRA and healthy control. Through detecting the plasma expression levels of eight candidate targets, we identified three circRNA (hsa_circ_001978, hsa_circ_105039, and hsa_circ_103627) with increased level which were consistent with the microarray results in training set. Further validation found the circRNA panel was consistent with training set. The ROC curve also revealed a high diagnostic ability of hsa_circ_001978, hsa_circ_105039, and hsa_circ_103627 in predicted the CRC from CRA patients (AUC = 0.966) as well as healthy controls (AUC = 0.969). No 35421275 circLPAR1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(METTL3-eIF3h) qRT-PCR//RIP//FISH CircLPAR1 was encapsulated in exosomes with high stability and detectability, and its expression in plasma exosomes was remarkably decreased during CRC development but recovered after surgery. Additionally, circLPAR1 was downregulated in CRC tissues and was associated with overall survival. Mechanistically, exosomal circLPAR1 was internalized by CRC cells, and it suppressed tumor growth, likely because exosomal circLPAR1 directly bound with eIF3h specifically suppressed the METTL3-eIF3h interaction, decreasing the translation of oncogene BRD4. Additionally, circLPAR1 was downregulated in CRC tissues and was associated with overall survival. No 35164758 hsa_circ_0060927 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-421/miR-195-5p) qRT-PCR//Transwell Assay Hsa_circ_0060927 expression was significantly upregulated, whereas miR-421 and miR-195-5p were downregulated in CRC tissues and cells compared with control groups. Caudatin treatment significantly decreased hsa_circ_0060927 expression but increased miR-421 and miR-195-5p expression. Hsa_circ_0060927 expression was closely associated with lymph node metastasis and tumor-node-metastasis stage. No 35373390 hsa_circ_0055625 CircRNA Homo sapiens Colonic Neoplasms colon cancer tissues Interaction[miR-106b-5p ] qRT-PCR//Microarray Among the top 10 Expression[Expression[up-expression]-expression]regulated circRNAs, hsa_circ_0055625 (circ_0055625) was confirmed to be significantly Expression[Expression[up-expression]-expression]regulated in colon cancer tissues.Further analysis demonstrated that circ_0055625 might get involved in the pathogenesis of colon cancer by functioning as miRNA sponges and performed bioinformatics analysis of the predicted circ_0055625/miR-106b-5p (miR-106b)/ITGB8 network. Moreover, we found that circ_0055625 expression was associated with pathological TNM stage and metastasis. No 30520100 circPIEZO1-3 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] circRNA-seq We have identified six potential key circRNAs (circPIEZO1-3, hsa_circ_0067163, hsa_circ_0140188, hsa_circ_0002632, hsa_circ_0001998 and hsa_circ_0023990) associated with CRC, which play important roles in carcinogenesis as ceRNA for regulation of miRNA-mRNA network. In the subsequent KEGG analysis, several CRC-related pathways were found. No 31579577 hsa_circ_0005075 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Expression[highly expressed] qRT-PCR Hsa_circ_0005075 was overexpressed in colorectal cancer tissues compared with paracancerous tissues and intestinal polyps. Hsa_circ_0005075 was overexpressed in colorectal cancer tissues compared with paracancerous tissues and intestinal polyps. Its expression level was associated with distal metastasis, invasion, tumor node metastasis stage, and tumor diameter in colorectal cancer, and was negatively correlated with overall survival of patients with colorectal cancer. No 31476947 circSPIDR CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 hsa_circ_0004585 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR//Microarray The hsa_circ_0004585 expression was significantly upregulated both in CRC patients tissue and peripheral blood. Hsa_circ_0004585 was positively correlated with patient's tumor size No 31354349 circFGD6 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circHOMER1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circAPLP2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circCDK8 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circMACROD1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circVAPA CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circTRAPPC9 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circPRKAG2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circITGAL CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circITFG2 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circABTB1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circDDX17 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circTRPM4 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circAMBRA1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circSCAND2P CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circLMF1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 circGIGYF1 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] CCK8//qRT-PCR//RNA-seq//Colony Formation Assay The top 10 dysregulated circRNAs are listed in Table 1. No 30591054 hsa_circ_103809 CircRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Regulation[miR-532-3p / FOXO4 axis] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Hsa_circRNA_103809 was found to be significantly down regulated in CRC tissues and cell lines and compared with paired adjacent non-tumorous tissues and normal FHC cells.Hsa_circRNA_103809 participates in the regulation of biological functions through the miR-532-3P/FOXO4 axis in the CRC. Hsa_circRNA_103809 (hsa_circ_0072088, circZFR)has been demonstrated to be lowly expressed in colorectal cancer tissues and is associated with stage and lymph node metastasis of cancer tissues. No 30249393 circHIPK3 CircRNA Homo sapiens Colorectal Neoplasms serum exosomes Expression[highly expressed] qRT-PCR In serum exosomes, UCA1 was downregulated, while circHIPK3 and TUG1 were upregulated. No 30195762 hsa_circ_0123778 CircRNA Homo sapiens Colorectal Neoplasms cancer tissues Expression[highly expressed] qRT-PCR Three circRNAs, hsa_circ_0020050, hsa_circ_0004030, and hsa_circ_0123778 (circ-CTNNB3), were upregulated in the tissues of gastric cancer, prostate cancer, and colorectal cancer No 30563889 hsa_circ_0000826 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues,cell lines(HT-30 cells and FHC) Expression[Expression[lower expressed]-expression] qRT-PCR//RNA-seq Subsequently, the results of sequencing were confirmed by reverse transcription-quantitative polymerase chain reaction, and hsa_circ_0000826 was found to be Expression[down-expression]regulated in CRC. No 30320923 circCCDC45 CircRNA Homo sapiens Colorectal Neoplasms blood Expression[Expression[lower expressed]-expression] qRT-PCR The plasma levels of three circRNAs (circ-CCDC66, circ-ABCC1 and circ-STIL) were significantly decreased in CRC patients (n = 45) compared with healthy controls (n = 61). Combining the circRNA panel with CEA and CA19-9 might improve the ability to diagnose CRC (AUC = 0.855). In addition, the plasma circ-ABCC1 level was related to tumor growth and progression, and the plasma circ-CCDC66 and circ-ABCC1 levels were decreased in precursor lesions of CRC, including colon adenomas and adenomatous polyps. More importantly, circ-CCDC66 and circ-STIL were found to be useful for diagnosing early-stage CRC, and the three-circRNA panel improved the ability to diagnose CEA-negative and CA19-9-negative CRC. No 31669510 circABCC61 CircRNA Homo sapiens Colorectal Neoplasms blood Expression[Expression[lower expressed]-expression] qRT-PCR The plasma levels of three circRNAs (circ-CCDC66, circ-ABCC1 and circ-STIL) were significantly decreased in CRC patients (n = 45) compared with healthy controls (n = 61). Combining the circRNA panel with CEA and CA19-9 might improve the ability to diagnose CRC (AUC = 0.855). In addition, the plasma circ-ABCC1 level was related to tumor growth and progression, and the plasma circ-CCDC66 and circ-ABCC1 levels were decreased in precursor lesions of CRC, including colon adenomas and adenomatous polyps. More importantly, circ-CCDC66 and circ-STIL were found to be useful for diagnosing early-stage CRC, and the three-circRNA panel improved the ability to diagnose CEA-negative and CA19-9-negative CRC. No 31669510 circSTIL CircRNA Homo sapiens Colorectal Neoplasms blood Expression[Expression[lower expressed]-expression] qRT-PCR The plasma levels of three circRNAs (circ-CCDC66, circ-ABCC1 and circ-STIL) were significantly decreased in CRC patients (n = 45) compared with healthy controls (n = 61). Combining the circRNA panel with CEA and CA19-9 might improve the ability to diagnose CRC (AUC = 0.855). In addition, the plasma circ-ABCC1 level was related to tumor growth and progression, and the plasma circ-CCDC66 and circ-ABCC1 levels were decreased in precursor lesions of CRC, including colon adenomas and adenomatous polyps. More importantly, circ-CCDC66 and circ-STIL were found to be useful for diagnosing early-stage CRC, and the three-circRNA panel improved the ability to diagnose CEA-negative and CA19-9-negative CRC. No 31669510 hsa_circ_0004771 CircRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR The up-regulated exosomal hsa-circ-0004771 was verified in serum of CRC patients compared to healthy controls (HCs) and patients with benign intestinal diseases (BIDs) by qRT-PCR. The area under the ROC curves (AUCs) of circulating exosomal hsa-circ-0004771 were 0.59 (95%CI, 0.457-0.725), 0.86 (95%CI, 0.785-0.933) and 0.88 (95%CI, 0.815-0.940) to differentiate BIDs, stage I/II CRC patients and CRC patients from HCs, respectively. The AUC was 0.816 (95%CI, 0.728-0.9) to differentiate stage I/II CRC patients from patients with BIDs. In addition, the elevated expression of exosomal hsa-circ-0004771 in the serum of CRC patients was tumor-derived. It was found that the expression of exosomal hsa-circ-0004771 was down-regulated expression of in the serum of postoperative CRC patients as well as cultured media of CRC cells treated with GW4869. No 31737058 hsa_circ_0082182 CircRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR Hsa_circ_0082182, hsa_circ_0000370 were shown significantly upregulated in CRC plasma, while the hsa_circ_0035445 was down-regulated (Figs. 2c, ​c,3a–c),3a–c), which was in accordance with the results of microarray analysis. No 31700498 hsa_circ_0000370 CircRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR Hsa_circ_0082182, hsa_circ_0000370 were shown significantly upregulated in CRC plasma, while the hsa_circ_0035445 was down-regulated (Figs. 2c, ​c,3a–c),3a–c), which was in accordance with the results of microarray analysis. No 31700498 hsa_circ_0035445 CircRNA Homo sapiens Colorectal Neoplasms blood Expression[lower expressed] qRT-PCR Hsa_circ_0082182, hsa_circ_0000370 were shown significantly upregulated in CRC plasma, while the hsa_circ_0035445 was down-regulated (Figs. 2c, ​c,3a–c),3a–c), which was in accordance with the results of microarray analysis. No 31700498 hsa_circ_0142527 CircRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[lower expressed] qRT-PCR Hsa_circ_0142527 and KLF4 mRNA were significantly lower expressed in CRC tissues in both training and confirm groups and have high positive correlation (r = 0.754). We further found that the expression levels of hsa_circ_0142527 were significantly associated with age (P = 0.004), differentiation (P = 0.008), invasion (P = 0.029), distal metastasis (P = 0.004), TNM stage (P = 0.005), and carcinoembryonic antigen (CEA; P = 0.037). No 31169949 hsa_circ_103868 CircRNA Homo sapiens Urinary Bladder Neoplasms cell lines(CCC-HB-2,SW780, 5637, T24, J82 and RT7) Expression[highly expressed] qRT-PCR Further qPCR results confirmed that has_circRNA_000542, has_circRNA_403658, has_circRNA_001747, has_circRNA_103868, and has_circRNA_030448 were significantly increased in hypoxia-cultured 5640 cells compared with normal-cultured cells No 31814891 hsa_circ_005484 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.125 No 31026505 hsa_circ_002341 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.28 No 31026505 hsa_circ_005345 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.30 No 31026505 hsa_circ_002026 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.31 No 31026505 hsa_circ_002944 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.32 No 31026505 hsa_circ_004941 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.33 No 31026505 hsa_circ_001115 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.34 No 31026505 hsa_circ_004838 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.35 No 31026505 hsa_circ_004058 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.36 No 31026505 hsa_circ_007194 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.37 No 31026505 hsa_circ_004840 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.38 No 31026505 hsa_circ_005048 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.39 No 31026505 hsa_circ_006986 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.40 No 31026505 hsa_circ_007099 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.41 No 31026505 hsa_circ_004430 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.42 No 31026505 hsa_circ_004272 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.43 No 31026505 hsa_circ_004252 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.44 No 31026505 hsa_circ_001462 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.45 No 31026505 hsa_circ_001461 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.46 No 31026505 hsa_circ_004786 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.47 No 31026505 hsa_circ_002776 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.48 No 31026505 hsa_circ_000900 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.49 No 31026505 hsa_circ_003937 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.50 No 31026505 hsa_circ_001913 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.51 No 31026505 hsa_circ_006411 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.52 No 31026505 hsa_circ_000486 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.53 No 31026505 hsa_circ_006758 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.54 No 31026505 hsa_circ_006757 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.55 No 31026505 hsa_circ_005371 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.56 No 31026505 hsa_circ_002303 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.57 No 31026505 hsa_circ_007305 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.58 No 31026505 hsa_circ_002342 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.29 No 31026505 hsa_circ_000102 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.27 No 31026505 hsa_circ_007157 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.60 No 31026505 hsa_circ_000372 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.26 No 31026505 hsa_circ_0138455 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 203 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0130728 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 204 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0091682 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 205 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0008678 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 206 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0116742 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 207 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0019985 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 208 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0007334 CircRNA Homo sapiens pancreatic ductal adenocarcinoma PDAC tissue Interaction[MMP7,COL1A1] qRT-PCR//Wound Healing Assay//Western Blot Of these, we found that hsa_circRNA_0007334 was significantly upregulated and may serve as a competing endogenous RNA to regulate matrix metallopeptidase 7 (MMP7) and collagen type I alpha 1 chain (COL1A1) by the competitive adsorption of hsa-miR-144-3p and hsa-miR-577 to enhance the expression and functions of MMP7 and COL1A1 in PDAC. In vitro experiments confirmed these results. No 31428151 circPVRL3 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Interaction(circPVRL3/miR-194-5p/SOCS2 axis) qRT-PCR//Western Blot Our findings indicated that an increase of miR-194-5p caused by circPVRL3 downregulation stimulates the PI3K/AKT signaling pathway to promote PDAC progression via the circPVRL3/miR-194-5p/SOCS2 axis, which suggests that the circPVRL3/miR-194-5p/SOCS2 axis may be a potential therapeutic target for PDAC patients. No 36539807 hsa_circ_002493 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.05 No 31026505 hsa_circ_003702 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.06 No 31026505 hsa_circ_003319 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.07 No 31026505 hsa_circ_006999 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.08 No 31026505 hsa_circ_006862 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.09 No 31026505 hsa_circ_005082 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.10 No 31026505 hsa_circ_006637 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.11 No 31026505 hsa_circ_006345 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.12 No 31026505 hsa_circ_000578 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.13 No 31026505 hsa_circ_001371 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.14 No 31026505 hsa_circ_001845 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.15 No 31026505 hsa_circ_002739 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.16 No 31026505 hsa_circ_003184 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.17 No 31026505 hsa_circ_006799 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.18 No 31026505 hsa_circ_000258 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.19 No 31026505 hsa_circ_003799 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.20 No 31026505 hsa_circ_006713 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.21 No 31026505 hsa_circ_003035 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.22 No 31026505 hsa_circ_004219 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.23 No 31026505 hsa_circ_001604 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.24 No 31026505 hsa_circ_006725 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.25 No 31026505 hsa_circ_002304 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.59 No 31026505 hsa_circ_006600 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.61 No 31026505 hsa_circ_0091122 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 201 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_004695 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.94 No 31026505 hsa_circ_004313 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.96 No 31026505 hsa_circ_004282 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.97 No 31026505 hsa_circ_003616 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.98 No 31026505 hsa_circ_000351 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.99 No 31026505 hsa_circ_005735 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.100 No 31026505 hsa_circ_003188 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.101 No 31026505 hsa_circ_003947 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.102 No 31026505 hsa_circ_006194 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.103 No 31026505 hsa_circ_005118 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.104 No 31026505 hsa_circ_001469 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.105 No 31026505 hsa_circ_001470 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.106 No 31026505 hsa_circ_004060 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.107 No 31026505 hsa_circ_006274 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.108 No 31026505 hsa_circ_003351 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.109 No 31026505 hsa_circ_002097 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.110 No 31026505 hsa_circ_001112 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.111 No 31026505 hsa_circ_002532 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.112 No 31026505 hsa_circ_004929 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.113 No 31026505 hsa_circ_002034 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.114 No 31026505 hsa_circ_004879 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.115 No 31026505 hsa_circ_006569 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.116 No 31026505 hsa_circ_002539 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.117 No 31026505 hsa_circ_001696 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.118 No 31026505 hsa_circ_004841 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.119 No 31026505 hsa_circ_002495 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.120 No 31026505 hsa_circ_001007 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.121 No 31026505 hsa_circ_002045 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.122 No 31026505 hsa_circ_005042 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.123 No 31026505 hsa_circ_006638 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.124 No 31026505 hsa_circ_006374 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.95 No 31026505 hsa_circ_004302 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.93 No 31026505 hsa_circ_001811 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.62 No 31026505 hsa_circ_003249 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.92 No 31026505 hsa_circ_002581 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.63 No 31026505 hsa_circ_004398 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.64 No 31026505 hsa_circ_006271 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.65 No 31026505 hsa_circ_007153 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.66 No 31026505 hsa_circ_000899 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.67 No 31026505 hsa_circ_002490 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.68 No 31026505 hsa_circ_005044 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.69 No 31026505 hsa_circ_003094 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.70 No 31026505 hsa_circ_003095 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.71 No 31026505 hsa_circ_001598 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.72 No 31026505 hsa_circ_001321 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.73 No 31026505 hsa_circ_003295 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.74 No 31026505 hsa_circ_002278 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.75 No 31026505 hsa_circ_000937 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.76 No 31026505 hsa_circ_001711 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.77 No 31026505 hsa_circ_000912 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.78 No 31026505 hsa_circ_003038 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.79 No 31026505 hsa_circ_000148 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.80 No 31026505 hsa_circ_002741 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.81 No 31026505 hsa_circ_005047 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.82 No 31026505 hsa_circ_004836 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.83 No 31026505 hsa_circ_003160 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.84 No 31026505 hsa_circ_004755 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.85 No 31026505 hsa_circ_003600 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.86 No 31026505 hsa_circ_001114 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.87 No 31026505 hsa_circ_002305 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.88 No 31026505 hsa_circ_005878 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.89 No 31026505 hsa_circ_001467 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.90 No 31026505 hsa_circ_001378 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.91 No 31026505 hsa_circ_0042341 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 202 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0119741 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 200 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_030448 CircRNA Homo sapiens Urinary Bladder Neoplasms cell lines(CCC-HB-2,SW780, 5637, T24, J82 and RT8) Expression[highly expressed] qRT-PCR Further qPCR results confirmed that has_circRNA_000542, has_circRNA_403658, has_circRNA_001747, has_circRNA_103868, and has_circRNA_030448 were significantly increased in hypoxia-cultured 5641 cells compared with normal-cultured cells No 31814891 hsa_circ_0008510 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137638 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0099708 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137640 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0096402 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137641 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0005004 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137642 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0005746 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137643 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0125309 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137644 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0005429 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137645 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0006784 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137646 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0001882 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137647 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0137606 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137648 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0000285 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[lower expressed] qRT-PCR Herein, qPCR measured the expression of hsa_circRNA_100783, hsa_circ_0000285 and hsa_circRNA_100782 in bladder cancer tissues. It was established that sa_circ_0000285, but not hsa_circRNA_100782 and hsa_circRNA_10078, are significantly reduced in bladder cancer tissues and serum compared to adjacent tissues and healthy controls. Moreover, hsa_circ_0000285 expression was lower in cisplatin-resistant bladder cancer patients than in those who were cisplatin-sensitive.Here, hsa_circ_0000285 was associated with tumor size (p<0.001), differentiation (p<0.001), lymph node metastasis (p=0.038), distant metastasis (p=0.004) and TNM stage (p=0.013). Further analysis showed that hsa_circ_0000285 would be an independent prognostic factor for bladder cancer patient outcome. No 30509102 hsa_circ_100783 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[lower expressed] qRT-PCR Herein, qPCR measured the expression of hsa_circRNA_100783, hsa_circ_0000285 and hsa_circRNA_100782 in bladder cancer tissues. It was established that sa_circ_0000285, but not hsa_circRNA_100782 and hsa_circRNA_10078, are significantly reduced in bladder cancer tissues and serum compared to adjacent tissues and healthy controls. No 30509102 circFARSA CircRNA Homo sapiens Urinary Bladder Neoplasms blood Expression[highly expressed] qRT-PCR When comparing patients with BC to healthy controls, the expression of lncRNA UCA1, circFARSA, and circSHKBP1 was significantly increased. No 31934131 circSHKBP1 CircRNA Homo sapiens Urinary Bladder Neoplasms blood Expression[highly expressed] qRT-PCR When comparing patients with BC to healthy controls, the expression of lncRNA UCA1, circFARSA, and circSHKBP1 was significantly increased. No 31934131 circBANP CircRNA Homo sapiens Urinary Bladder Neoplasms blood Expression[highly expressed] qRT-PCR When comparing patients with BC to healthy controls, the expression of lncRNA UCA1, circFARSA, and circSHKBP1 was significantly increased. No 31934131 hsa_circ_0018069 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[lower expressed] qRT-PCR The expression of hsa_circ_0018069 was significantly reduced in T24 and Biu-87 cells and was also significantly downregulated in bladder cancer tissues. Decreased expression of hsa_circ_0018069 was related to the grade stage (P=0.024), T stage (P=0.027), and muscular invasion depth (P=0.022) of bladder cancer. No 30984788 circINTS4 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues,cell lines Regulation[circINTS4/miR-146b/CARMA3 axis] qRT-PCR Expression of circINTS4 was significantly increased in miR-146b-downregulated BC tissues and cell lines compared to adjacent normal tissues.In summary, the circINTS4/miR-146b/CARMA3 axis might serve as a promising therapeutic target for BC intervention. No 30723269 hsa_circ_5912 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[lower expressed] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay In this study, we reanalyzed our previous RNA sequence, and circ5912 was found to downregulate significantly in bladder cancer tissues compared with normal control. Expression of circ5912 inversely correlates with bladder cancer grade, stage, metastasis, and better patient outcomes. No 31808751 hsa_circ_0003141 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[highly expressed] qRT-PCR Hsa_circ_0003141 and hsa_circ_0008039 were significantly upregulated as well as hsa_circ_0026782, hsa_circ_0077837, hsa_circ_0004826, and hsa_circ_0001946 were significantly downregulated among validation of 70 matched bladder cancer tissues (≥75%). No 32250047 hsa_circ_0008039 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[highly expressed] qRT-PCR Hsa_circ_0003141 and hsa_circ_0008039 were significantly upregulated as well as hsa_circ_0026782, hsa_circ_0077837, hsa_circ_0004826, and hsa_circ_0001946 were significantly downregulated among validation of 70 matched bladder cancer tissues (≥75%). No 32250047 hsa_circ_0026782 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[lower expressed] qRT-PCR Hsa_circ_0003141 and hsa_circ_0008039 were significantly upregulated as well as hsa_circ_0026782, hsa_circ_0077837, hsa_circ_0004826, and hsa_circ_0001946 were significantly downregulated among validation of 70 matched bladder cancer tissues (≥75%). No 32250047 hsa_circ_0077837 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[lower expressed] qRT-PCR Hsa_circ_0003141 and hsa_circ_0008039 were significantly upregulated as well as hsa_circ_0026782, hsa_circ_0077837, hsa_circ_0004826, and hsa_circ_0001946 were significantly downregulated among validation of 70 matched bladder cancer tissues (≥75%). No 32250047 hsa_circ_0004826 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[lower expressed] qRT-PCR Hsa_circ_0003141 and hsa_circ_0008039 were significantly upregulated as well as hsa_circ_0026782, hsa_circ_0077837, hsa_circ_0004826, and hsa_circ_0001946 were significantly downregulated among validation of 70 matched bladder cancer tissues (≥75%). No 32250047 hsa_circ_0001946 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[lower expressed] qRT-PCR Hsa_circ_0003141 and hsa_circ_0008039 were significantly upregulated as well as hsa_circ_0026782, hsa_circ_0077837, hsa_circ_0004826, and hsa_circ_0001946 were significantly downregulated among validation of 70 matched bladder cancer tissues (≥75%). No 32250047 hsa_circ_100241 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[highly expressed] qRT-PCR The results from RT-qPCR demonstrated that hsa_circ_100241, hsa_circ_100242 and hsa_circ_101303 were markedly upregulated whereas hsa_circ_104510 was significantly downregulated in bladder cancer tissues compared with normal tissue. No 32218853 hsa_circ_100242 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[highly expressed] qRT-PCR The results from RT-qPCR demonstrated that hsa_circ_100241, hsa_circ_100242 and hsa_circ_101303 were markedly upregulated whereas hsa_circ_104510 was significantly downregulated in bladder cancer tissues compared with normal tissue. No 32218853 hsa_circ_101303 CircRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression[lower expressed] qRT-PCR The results from RT-qPCR demonstrated that hsa_circ_100241, hsa_circ_100242 and hsa_circ_101303 were markedly upregulated whereas hsa_circ_104510 was significantly downregulated in bladder cancer tissues compared with normal tissue. No 32218853 hsa_circ_0008399 CircRNA Homo sapiens Urinary Bladder Neoplasms Bladder cancer tissues and cell lines Expression [highly expressed] Co-IP//FISH//RIP//qRT-PCR//RNA-seq Here we report upregulation of a novel circRNA, hsa_circ_0008399 (circ0008399), by eukaryotic translation initiation factor 4A3 (EIF4A3) in bladder cancer tissues and cell lines. Functionally, circ0008399 inhibited apoptosis of bladder cancer cells. Mechanistically, circ0008399 bound Wilms' tumor 1-associating protein (WTAP) to promote formation of the WTAP/METTL3/METTL14 m6A methyltransferase complex. Circ0008399 increased expression of TNF alpha-induced protein 3 (TNFAIP3) by increasing its mRNA stability in an m6A-dependent manner. In patients with bladder cancer, high expression of circ0008399 and WTAP was associated with poor outcomes. Importantly, activation of the circ0008399/WTAP/TNFAIP3 pathway decreased bladder cancer chemosensitivity to CDDP, and targeting the circ0008399/WTAP/TNFAIP3 axis enhanced the CDDP efficacy. Collectively, these findings give novel insights into circRNA-mediated regulation of m6A modifications and provide potential therapeutic targets for bladder cancer. No 34702726 circSETD3 CircRNA Homo sapiens Urinary Bladder Neoplasms clinical tissues and cell lines Interaction( miR-641/PTEN axis.) CCK8//qRT-PCR CircSETD3 was remarkably downregulated in the cancerous clinical tissues and cell lines, in contrast with their normal counterparts, and circSETD3 tended to be deficient in BLCA patients with larger tumor size, advanced clinical stages, positive lymph metastasis and worse prognosis. Mechanistically, circSETD3 sponged miR-641 to upregulate PTEN, resulting in the blockage of BLCA progression. CircSETD3 was remarkably downregulated in the cancerous clinical tissues and cell lines, in contrast with their normal counterparts, and circSETD3 tended to be deficient in BLCA patients with larger tumor size, advanced clinical stages, positive lymph metastasis and worse prognosis. No 34288821 circTRPS1 CircRNA Homo sapiens Urinary Bladder Neoplasms Exosomes Interaction(circTRPS1/miR141-3p/GLS1 axis) qRT-PCR//RNA Pull-Down//RIP We identified that exosome-derived hsa_circ_0085361 (circTRPS1) was correlated with aggressive phenotypes of BCa cells via sponging miR-141-3p. Metabolomics and RNA sequencing (RNA-seq) identified GLS1-mediated glutamine metabolism was involved in circTRPS1-mediated alterations. Exosomes derived from circTRPS1 knocked down BCa cells, prevented CD8+ T cells from exhaustion, and repressed the malignant phenotype of BCa cells. In conclusion, exosome-derived circTRPS1 from BCa cells can modulate the intracellular reactive oxygen species (ROS) balance and CD8+ T cell exhaustion via the circTRPS1/miR141-3p/GLS1 axis. Our work may provide a potential biomarker and therapeutic target for BCa. No 35038580 hsa_circ_0008426 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137639 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0102172 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137637 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_001242 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] qRT-PCR Hsa_circ_001242 was significantly downregulated in OSCC tissues compared to paired adjacent normal tissues (P < 0.001). Moreover, the expression level of hsa_circ_001242 was negatively correlated with tumor size and T stage (P < 0.05). No 30069275 hsa_circ_0004113 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137636 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0020840 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[differently expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137606 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0103136 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[differently expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137607 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0078816 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[differently expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137608 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0030392 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[differently expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137609 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0071818 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[differently expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137610 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0006329 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[differently expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137611 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0002099 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[differently expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137612 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0136698 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137614 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0099364 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137615 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0071820 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137616 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0081963 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137617 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0063865 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137618 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0009130 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137619 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0114699 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137620 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0007632 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137621 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0088274 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137622 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0115417 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137623 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0140725 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137624 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0023256 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137625 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0001377 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137626 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0139039 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137627 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0007071 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137628 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0082583 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137629 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0006423 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137630 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0128896 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137631 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0124765 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137632 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0007766 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137633 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0072654 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137634 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0109103 CircRNA Homo sapiens Urinary Bladder Neoplasms breast cancer tissues Expression[Expression[lower expressed]-expression] CCK8//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay In high-grade BC tissues, 316 circRNAs were dysregulated compared with NCs (205 Expression[Expression[up-expression]-expression]regulated and 111 Expression[down-expression]regulated) and 244 circRNAs were dysregulated compared with low-grade BC tissues (109 Expression[Expression[up-expression]-expression]regulated and 135 Expression[down-expression]regu-lated). Further analysis indicated that 42 dysregulated circRNAs overlapped between the two groExpression[Expression[up-expression]-expression]s (Table I). As shown in Fig. 2A-G, the RT-qPCR results were consistent with the expression profiles of our high-throughput sequencing data, in which, hsa_circ_0137635 exhibited a high degree of Expression[down-expression]regulation. No 30892069 hsa_circ_0008309 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] qRT-PCR//Western Blot Hsa_circ_0008309 was significantly downregulated in 45 pairs of OSCC tissue samples and was statistically correlated with pathological differentiation. No 30344795 hsa_circ_0001874 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Expression[highly expressed] qRT-PCR Among the differentially expressed circRNAs, hsa_circ_0001874, hsa_circ_0001971, and hsa_circ_0008068 were upregulated and hsa_circ_0000140, hsa_circ_0002632, and hsa_circ_0008792 were downregulated in the OSCC group versus the healthy group. Clinical data indicated that salivary hsa_circ_0001874 was correlated with TNM stage (P=0.006) and tumor grade (P=0.023) and that hsa_circ_0001971 was correlated with TNM stage (P=0.019). No 29991057 hsa_circ_0013652 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 199 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0017204 CircRNA Homo sapiens Parkinson Disease plasma samples of PD Expression(highly expressed) qRT-PCR//Microarray Four circRNAs (circ_0085869, circ_0004381, circ_0017204, and circ_0090668) were obtained with increased levels in PD patients by cross comparison and preliminary verification in PD comparing with healthy controls. No 34276342 circSV2b CircRNA Homo sapiens Parkinson Disease PD models Interaction(miR-5107-5p-Foxk1-Akt1 axis) RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay Quantitative real-time PCR was used to determine the RNA level of DECs in the striatum (STR), substantia nigra pars compacta (SNpc), and serum exosomes, and it was found that circSV2b was downregulated in PD mice. In vivo, the mechanistic analysis demonstrated that circSV2b overexpression resisted oxidative stress damage through the ceRNA-Akt1 axis in PD models. No 35973363 hsa_circ_0000370 CircRNA Homo sapiens Leukemia, Myeloid, Acute blood Interaction[regulating miR-1299 and S100A7A] qRT-PCR In the present study, circ_0000370 was found to be significantly increased in FLT3-ITD AML and was demonstrated to act as an oncogenic circRNA of AML in vitro. TargetScan results showed that miR-1299, miR-370-3p, miR-502-5p, miR-1281 and miR-640 were potential targets of circ_0000370, and miR-1299 had the broadest range of interactome compared with other microRNAs of interest. Moreover, we demonstrated that S100A7A was a target gene of miR-1299, and circ_0000370 could regulate S100A7A expression by sponging miR-1299 in AML cell lines. Therefore, we suggest that the promoting effects of circ_0000370 on the progression of FLT3-ITD AML might be relevant to the inhibition of miR-1299 and the upregulation of S100A7A. +++ No 31919040 circVIM CircRNA Homo sapiens Leukemia, Myeloid, Acute blood Expression[highly expressed] qRT-PCR Circ-VIM was significantly upregulated in AML compared with control and was positively correlated with white blood cells (WBC) count. Survival analyses further showed that over-expressed Circ-VIM were associated with markedly shorter overall survival (OS) and leukemia-free survival (LFS) in whole-cohort AML, nonacute promyelocytic leukemia AML and cytogenetically normal-AML patients. Multivariate analysis also disclosed that Circ-VIM over-expression was an independent poor prognostic factor for OS and LFS in AML patients. No 30152863 circFoxo3 CircRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow Expression[lower expressed] qRT-PCR Meanwhile, circ-Foxo3 also expressed lower in de novo AML patients than in control samples (P = 0.040). No 31533653 hsa_circ_0075451 CircRNA Homo sapiens Leukemia, Myeloid, Acute 218 CN-AML patients Interaction(miR-330-5p/miR-326 ) qRT-PCR//Luciferase Report Assay We identified 308 circRNAs as independent candidate predictors of overall survival.Hsa_circ_0075451 expression was validated as an independent predictor with a weak predictive ability for overall survival.The regulatory axis of hsa_circ_0075451 -| miR-330-5p/miR-326 -| PRDM16 was validated by the dual luciferase report assay, fluorescence in situ hybridization, and ShRNA interference assay. Hsa_circ_0075451 expression was validated as an independent predictor with a weak predictive ability for overall survival. No 33517886 circPVT1 CircRNA Homo sapiens Leukemia, Myeloid, Acute AML patients Regulation Survival Analysis Circ-PVT1 expression was different among AML patients, disease controls and health donors, which was highest in AML patients, followed by disease controls and lowest in health donors. Besides, high circ-PVT1 expression was correlated with shorter EFS and OS in AML patients. No 34871521 circANAPC7 CircRNA Homo sapiens Leukemia, Myeloid, Acute AML patients Expression(highly expressed) qRT-PCR Circ-ANAPC7 was first found to be upregulated in AML, and its expression was correlated to white blood cell counts in peripheral blood and blast percentage in bone marrow. ROC curve analysis revealed that circ-ANAPC7 has a significant value of auxiliary AML diagnosis (area under the curve = 0.915, p < 0.001). Furthermore, the expression level of circ-ANAPC7 was changed accompanied with disease condition transformation. No 34879367 hsa_circ_0079480 CircRNA Homo sapiens Leukemia, Myeloid, Acute serum Expression(highly expressed) qRT-PCR Acute myeloid leukemia patients were found to exhibit significant hsa_circ_0079480 upregulation in their serum as compared to serum from healthy controls, with such upregulation being most profound in individuals with M4/M5 type disease and to be more common in patients with poor cytogenic risk or high white blood cell counts. Moreover, the upregulation of serum hsa_circ_0079480 was found to be closely related to clinicopathological findings and to be an independent predictor of reduced overall and relapse-free survival among individuals diagnosed with AML. No 35297094 hsa_circ_100873 CircRNA Homo sapiens Esophageal Neoplasms esophageal cancer tissues,cell lines (Eca109, kyse410, kyse510, TE-1, TE-5) Expression[differently expression] qRT-PCR//Microarray The RT-qPCR data and gene chip analysis consistently identified hsa_circRNA_100873 as differentially expressed among the examined groExpression[Expression[up-expression]-expression]s. No 31788127 hsa_circ_0002130 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 179 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0000896 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 180 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0101692 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 181 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0005882 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 182 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0001250 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 183 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0037096 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 184 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0000128 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 185 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0000606 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 186 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0007177 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 187 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0008590 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 188 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0006404 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 189 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0005552 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 190 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0008615 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 191 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0074368 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 192 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0001821 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[Expression[highly expressed]-expression] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 193 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0103896 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 194 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0006662 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 195 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0092763 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 196 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0035432 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 197 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0094190 CircRNA Homo sapiens pancreatic ductal adenocarcinoma Blood Expression[lower expressed] qRT-PCR//circRNA-seq circRNAs in EV samples from plasma of eight patients with PDAC and eight normal healthy volunteers were sequenced, and the circRNA‐seq reads of each sample are shown in Table ​Table2.2. A total of 453 significantly differentially expressed circRNAs were finally identified using the criteria of fold change ≥ 2.0 and P ≤ 0.05. Among these circRNAs, 274 were Expression[Expression[up-expression]-expression]‐regulated and 198 were Expression[down-expression]‐regulated. No 31605569 hsa_circ_0090668 CircRNA Homo sapiens Parkinson Disease plasma samples of PD Expression(highly expressed) qRT-PCR//Microarray Four circRNAs (circ_0085869, circ_0004381, circ_0017204, and circ_0090668) were obtained with increased levels in PD patients by cross comparison and preliminary verification in PD comparing with healthy controls. No 34276342 hsa_circ_0004381 CircRNA Homo sapiens Parkinson Disease plasma samples of PD Expression(highly expressed) qRT-PCR//Microarray Four circRNAs (circ_0085869, circ_0004381, circ_0017204, and circ_0090668) were obtained with increased levels in PD patients by cross comparison and preliminary verification in PD comparing with healthy controls. No 34276342 hsa_circ_0001971 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Expression[highly expressed] qRT-PCR Among the differentially expressed circRNAs, hsa_circ_0001874, hsa_circ_0001971, and hsa_circ_0008068 were upregulated and hsa_circ_0000140, hsa_circ_0002632, and hsa_circ_0008792 were downregulated in the OSCC group versus the healthy group. Clinical data indicated that salivary hsa_circ_0001874 was correlated with TNM stage (P=0.006) and tumor grade (P=0.023) and that hsa_circ_0001971 was correlated with TNM stage (P=0.019). No 29991057 hsa_circ_0085869 CircRNA Homo sapiens Parkinson Disease plasma samples of PD Expression(highly expressed) qRT-PCR//Microarray Four circRNAs (circ_0085869, circ_0004381, circ_0017204, and circ_0090668) were obtained with increased levels in PD patients by cross comparison and preliminary verification in PD comparing with healthy controls. No 34276342 hsa_circ_0008068 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Expression[highly expressed] qRT-PCR Among the differentially expressed circRNAs, hsa_circ_0001874, hsa_circ_0001971, and hsa_circ_0008068 were upregulated and hsa_circ_0000140, hsa_circ_0002632, and hsa_circ_0008792 were downregulated in the OSCC group versus the healthy group. Clinical data indicated that salivary hsa_circ_0001874 was correlated with TNM stage (P=0.006) and tumor grade (P=0.023) and that hsa_circ_0001971 was correlated with TNM stage (P=0.019). No 29991057 hsa_circ_0000140 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Expression[lower expressed] qRT-PCR Among the differentially expressed circRNAs, hsa_circ_0001874, hsa_circ_0001971, and hsa_circ_0008068 were upregulated and hsa_circ_0000140, hsa_circ_0002632, and hsa_circ_0008792 were downregulated in the OSCC group versus the healthy group. Clinical data indicated that salivary hsa_circ_0001874 was correlated with TNM stage (P=0.006) and tumor grade (P=0.023) and that hsa_circ_0001971 was correlated with TNM stage (P=0.019). No 29991057 hsa_circ_0002632 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Expression[lower expressed] qRT-PCR Among the differentially expressed circRNAs, hsa_circ_0001874, hsa_circ_0001971, and hsa_circ_0008068 were upregulated and hsa_circ_0000140, hsa_circ_0002632, and hsa_circ_0008792 were downregulated in the OSCC group versus the healthy group. Clinical data indicated that salivary hsa_circ_0001874 was correlated with TNM stage (P=0.006) and tumor grade (P=0.023) and that hsa_circ_0001971 was correlated with TNM stage (P=0.019). No 29991057 hsa_circ_0008792 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Expression[lower expressed] qRT-PCR Among the differentially expressed circRNAs, hsa_circ_0001874, hsa_circ_0001971, and hsa_circ_0008068 were upregulated and hsa_circ_0000140, hsa_circ_0002632, and hsa_circ_0008792 were downregulated in the OSCC group versus the healthy group. Clinical data indicated that salivary hsa_circ_0001874 was correlated with TNM stage (P=0.006) and tumor grade (P=0.023) and that hsa_circ_0001971 was correlated with TNM stage (P=0.019). No 29991057 hsa_circ_100533 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues,cell lines Interaction[hsa_miR_933 ] qRT-PCR//Luciferase Report Assay//RIP//Microarray circRNA microarrays and quantitative real-time polymerase chain reaction was used to identify the hsa_circRNA_100533 Expression[down-expression]regulated in OSCC tissues and cell lines. Based on the luciferase reporter assay and AGO2 RIP assay, we found that hsa_circRNA_100533 binds to miRNAs as a miRNA sponge. No 31297884 hsa_circ_009755 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] qRT-PCR The measurement results from qRT-PCR revealed that hsa_circ_009755 expression was low in OSCC tissue samples and cell lines, and the low expression of hsa_circ_009755 was closely related to a clinicopathological feature in patients with OSCC. The measurement results from qRT-PCR revealed that hsa_circ_009755 expression was low in OSCC tissue samples and cell lines, and the low expression of hsa_circ_009755 was closely related to a clinicopathological feature in patients with OSCC. No 31213827 hsa_circ_0002203 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues,cell lines Expression[lower expressed] Western Blot//Wound Healing Assay//CCK8//Flow Cytometry//PCR//Transwell Assay The expression of circular RNA hsa_circ_0002203 in OSCC tissues was lower than that in adjacent tissues (P<0.01), and the expression in OSCC cell lines was lower than that in HOK (P<0.001). No 31721499 hsa_circ_0072387 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Expression[lower expressed] qRT-PCR Our data showed that hsa_circ_0072387 expression in OSCC was significantly downregulated compared with adjacent normal tissues (p < 0.001). Compared to human normal oral keratinocyte cell, the levels of hsa_circ_0072387 were lower in three OSCC cell lines (SCC25, SCC15, CAL27). More significantly, hsa_circ_0072387 expression was associated with the TNM stage in OSCC (p = 0.050). The area under the ROC curve reached up to 0.746. No 30908839 hsa_circ_0092125 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues and cell lines Expression[lower expressed] qRT-PCR The expression of hsa_circ_0092125 was significantly down-regulated in OSCC tissues and cell lines. A low expression of hsa_circ_0092125 was associated with clinicopathological factors in OSCC patients, including tumour size, TNM stage, and lymph node metastasis. Kaplan-Meier survival analysis indicated that the OS time was shorter in OSCC patients with a lower hsa_circ_0092125 expression level than in those with a higher expression level. In addition, univariate and multivariate Cox analysis identified lower hsa_circ_0092125 expression, tumour size, TNM stage, and lymph node metastasis as independent risk factors for the OSCC prognosis. No 31427049 hsa_circ_0003829 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues,cell lines Expression[lower expressed] qRT-PCR Hsa_circ_0003829 was significantly downregulated in OSCC compared with adjacent normal tissues. The area under the ROC curve was 0.81. Low expression levels of hsa_circ_0003829 in OSCC tissues were negatively correlated with lymph node metastasis status and TNM stage. No 32993417 hsa_circ_0086414 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissue samples and OSCC cells Expression[lower expressed] qRT-PCR Hsa_circ_0086414 expression in OSCC tissue samples and OSCC cells was first discovered to be significantly downregulated compared with the adjacent healthy tissues (AHTs) and normal (HaCaT) cells, respectively. Moreover, its expression level was significantly correlated with stage in TNM, size of tumor, and lymph node metastasis. No 31933490 hsa_circ_047733 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck patients with LNM Interaction(miR-4464/miR-4748) qRT-PCR The hsa_circRNA_047733 was further verified to be significantly downregulated in patients with LNM (+) as compared with those with LNM (-) (p = 0.007). The bioinformatics prediction showed that hsa_circRNA_047733 might sponge miR-4464/miR-4748 to regulate RPS21 expression. Patients with the higher expression of hsa_circRNA_047733 showed a lower risk of LNM (multivariate-adjusted OR = 0.22, 95%CI: 0.06-0.83). No 36300546 circOMAC CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression(highly expressed) qRT-PCR//Wound Healing Assay//Transwell Assay Our findings suggested that circ-OMAC was aberrantly elevated in the metastatic lymph nodes as compared to primary OSCC tissues. By developing functional assays, we confirmed that circ-OMAC promotes metastasis of OSCC cells via initiation of EMT pathways. OSCC patients with high levels of circ-OMAC were prone to a poor prognosis. No 36135340 circRFWD3 CircRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tissues and cell lines Interaction(miR-27a/b/PPARγ signaling) In Vivo Experiment//qRT-PCR//H&E Staining Here, we demonstrated that the circRFWD3 was significantly upregulated in HNSCC tissues and cell lines by circRNA microarray analysis and qPCR. Mechanistically, a dual-luciferase reporter assay, FISH, RIP, RNA pull-down, RNA-seq, and western blot experiments were employed and found that circRFWD3 served as a miRNAs sponge for miR-27a/27b, leading to the upregulation of PPARγ, and then promoted HNSCC metastasis via NF-κB/MMP13 pathway. Notably, high expression of circRFWD3 is related to highly aggressive HNSCC cell lines and lymph node metastasis in HNSCC patients. No 35690612 hsa_circ_0081001 CircRNA Homo sapiens Osteosarcoma OS cell lines, tissues and serums Expression[highly expressed] qRT-PCR In the current study, we identified a novel circRNA, hsa_circ_0081001, screened by the RNA sequencing in the three paired chemo-resistant and chemo-sensitive OS cell lines (MG63/DXR vs MG63, KHOS/DXR vs KHOS, U2OS/DXR vs U2OS), and found that hsa_circ_0081001 was significantly up-regulated in the OS cell lines, tissues and serums, associated with poor overall survival and cox multivariate analysis showed that hsa_circ_0081001 was a novel independent prognostic factor for OS patients. In the current study, we identified a novel circRNA, hsa_circ_0081001, screened by the RNA sequencing in the three paired chemo-resistant and chemo-sensitive OS cell lines (MG63/DXR vs MG63, KHOS/DXR vs KHOS, U2OS/DXR vs U2OS), and found that hsa_circ_0081001 was significantly up-regulated in the OS cell lines, tissues and serums, associated with poor overall survival and cox multivariate analysis showed that hsa_circ_0081001 was a novel independent prognostic factor for OS patients. No 30263004 hsa_circ_0001658 CircRNA Homo sapiens Osteosarcoma OS tissues Regulation[miR-382-5p/YB-1 axis] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Compared with adjacent tissues, circ_0001658 displayed a significantly higher expression in OS tissues.Circ_0001658 could facilitate the proliferation, migration, and invasion of OS cells and impede apoptosis by sponging miR-382-5p. Circ_0001658 promotes the proliferation and metastasis of OS cells via modulating miR-382-5p/YB-1 axis. No 31758574 circTADA2A CircRNA Homo sapiens Osteosarcoma OS tissue and cell lines Interaction[sponging miR-203a-3p] Western Blot//qRT-PCR//RIP//FISH//Transwell Assay Our findings demonstrated that circTADA2A was highly expressed in both OS tissue and cell lines, and circTADA2A inhibition attenuated the migration, invasion and proliferation of OS cells in vitro as well as tumorigenesis and metastasis in vivo. A mechanistic study revealed that circTADA2A could readily sponge miR-203a-3p to upregulate the expression of CREB3, which was identified as a driver gene in OS. Furthermore, miR-203a-3p inhibition or CREB3 overexpression could reverse the circTADA2A silencing-induced impairment of malignant tumor behavior. Our findings demonstrated that circTADA2A was highly expressed in both OS tissue and cell lines, and circTADA2A inhibition attenuated the migration, invasion and proliferation of OS cells in vitro as well as tumorigenesis and metastasis in vivo. No 30940151 hsa_circ_0021347 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction[B7-H3] qRT-PCR//Wound Healing Assay//Microarray//Western Blot As a result, hsa_circ0021347 was selected and validated to be significantly downregulated in OS tissues and cell lines and showed a strong negative relationship with B7-H3 expression in OS. In addition, clinicopathological features showed that hsa_circ0021347 in OS tissues was negatively associated with Enneking stage and positively associated with patients' survival. No 31950059 hsa_circ_0000885 CircRNA Homo sapiens Osteosarcoma blood Expression[highly expressed] qRT-PCR Hsa_circ_0000885 expression was significantly increased in tissue and serum samples from patients with osteosarcoma, compared with controls, with significantly increased expression levels in patients with Enneking stage IIB and III osteosarcoma, compared with early-stage osteosarcoma. Patients with high serum and tumor levels of hsa_circ_0000885 had lower rates of disease-free survival and overall survival. The serum expression levels of hsa_circ_0000885 were significantly higher in patients with osteosarcoma compared with patients with benign bone tumors or healthy controls. No 30802235 circLARP4 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues Expression[lower expressed] CCK8//qRT-PCR Circ-LARP4 was downregulated in tumor tissue compared with non-tumor tissue and had a good value in distinguishing tumor tissue from non-tumor tissue with an area under curve of 0.829 (95% CI: 0.762-0.859). No 31642110 hsa_circ_103801 CircRNA Homo sapiens Osteosarcoma blood Expression[highly expressed] qRT-PCR The level of hsa_circ_103801 was upregulated in the serum exosomes from patients with OS, and OS patients with high hsa_circRNA_103801 expression had a shorter survival time relative to patients with low hsa_circ_103801 expression. The level of hsa_circ_103801 was upregulated in the serum exosomes from patients with OS, and OS patients with high hsa_circRNA_103801 expression had a shorter survival time relative to patients with low hsa_circ_103801 expression. No 33325136 circTADA2A CircRNA Homo sapiens Osteosarcoma cell lines Expression[highly expressed] qRT-PCR CircTADA2A was upregulated while miR-129-5p was downregulated in MG63 and U2OS cells compared. No 33293831 hsa_circ_0003074 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues,cell lines,blood Expression[highly expressed] qRT-PCR High expression of hsa_circ_0003074 was detected in osteosarcoma tissues, peripheral blood and osteosarcoma cell lines In addition, hsa_circ_0003074 was closely related to clinical characteristics, such as tumor size, lung metastasis, enneking stage, and chemotherapy resistance. The ROC curve showed that hsa_circ_0003074 was a good diagnostic indicator for osteosarcoma, and survival analysis results revealed that high expression of hsa_circ_0003074 affected the survival of patients. No 33061621 hsa_circ_001621 CircRNA Homo sapiens Osteosarcoma osteosarcoma tissues interaction[ miR-578] Western Blot//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Microarray Here we identified circ_001621 as one of the significantly upregulated circular RNAs (circRNAs) by circRNAs microarrays.Results indicated circ_001621-promoted osteosarcoma proliferation and migration via attenuating the inhibition of cyclin-dependent kinase 4 (CDK4) and matrix metallopeptidase 9 (MMP9) by miR-578, respectively. We found that patients with high circ_001621 expression had a shorter survival time. No 31907361 hsa_circ_0005909 CircRNA Homo sapiens Osteosarcoma OS tissues and cell lines Interaction(miR-338-3p/HMGA1 Axis) CCK8//qRT-PCR Expression of circ_0005909 was upregulated in both OS tissues and cell lines. Cell viability and cell clones were inhibited by knockdown of circ_0005909 but increased by dual inhibition of circ_0005909 and miR-338-3p. Phosphorylation of ERK, Akt, and PI3K was inhibited by sh-circ_0005909, while this inhibition was repressed by co-transfection of sh-circ_0005909 and HGMA1. No 33536787 hsa_circ_0006948 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Interaction(miR-490-3p target ATG7) qPCR//Transwell Assay//PCR//IF The mRNA expression levels of circ_0006948, miR-490-3p and ATG7 in SAOS-2 cells were significantly different from NHOst cells (P<0.01). The mRNA expression levels of circ_0006948, miR-490-3p and ATG7 in osteosarcoma tissues were significantly different from adjacent tissues (P<0.01). The numbers of cell clone, migration and mobility in circ_0006948-siRNA group were (32.78±1.76), (37.58±1.82) and (36.93±1.45)%, respectively, lower than (65.72±1.45), (78.63±1.93) and (65.32±1.74)% in the siRNA NC group (all P<0.01). The numbers of cell clone, migration and mobility in the miR-490-3p mimics group were (20.08±1.54), (30.24±1.78) and (21.15±1.68)%, respectively, lower than (60.36±1.83), (76.93±1.64) and (40.56±1.27)% in the mimics NC group (all P<0.01). The numbers of cell clone, migration and mobility in the miR-490-3p inhibitor+ siRNA NC group were (90.34±1.72), (120.89±2.34) and (70.83±1.93)%, respectively, higher than (61.27±1.73), (75.82±1.82) and (42.38±1.74)% in the inhibitor NC+ siRNA NC group (P<0.01). The numbers of cell clone, migration and mobility in the circ_0006948 siRNA+ miR-490-3p inhibitor group were (58.74±1.98), (73.46±1.04) and (40.35±1.72)%, respectively, lower than (90.34±1.72), (120.89±2.34) and (70.83±1.93)% in the miR-490-3p inhibitor+ siRNA NC group (P<0.01). The numbers of cell clone, migration and mobility in the ATG7 siRNA group were (20.56±1.87), (40.36±1.76) and (20.96±1.73)%, lower than (65.46±1.74), (90.87±2.32) and (40.87±2.03)% in the siRNA NC group (P<0.01). The absorbance of miR-490-3p mimics+ pcDNA-ATG7 group was 0.54±0.11, higher than (0.36±0.08) of miR-490-3p mimics group (P<0.05). The expression levels of Bax and Bcl-2 protein in Saos-2 cells of miR-490-3p mimics group were significantly different from mimics NC group (P<0.01). The protein expression levels of Bax and Bcl-2 in Saos-2 cells of miR-490-3p mimics + pcDNA-ATG7 group were significantly different from miR-490-3p mimics group (P<0.01). No 33902208 hsa_circ_0024831 CircRNA Homo sapiens Osteosarcoma osteosarcoma cells Interaction(SND1 ) Other The down-regulation of circ0024831 expression in osteosarcoma cells relieved inhibition of SND1 which lead to change of tumor-related gene expression profile, promoting the occurrence and development of osteosarcoma. No 35484754 circAGO2 CircRNA Homo sapiens Neoplasms cancer tissues Expression[highly expressed] RNA Pull-Down//Northern Blot//Western Blot//Co-IP//qRT-PCR//FISH//RIP//Luciferase Report Assay//RNA-seq CircAGO2 is up-regulated in gastric cancer, colon cancer, prostate cancer, and neuroblastoma, and is associated with poor prognosis of patients. No 30341421 hsa_circ_003905 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.654 No 31026505 hsa_circ_003244 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.656 No 31026505 hsa_circ_001846 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Blood of 206 NSCLC patients and 206 healthy controls Expression [highly expressed] qRT-PCR//ELISA//Microarray A qPCR approach revealed that NSCLC patients exhibited higher serum circRNA_001846 levels as compared to healthy study participants. No 34635012 hsa_circ_000509 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1365 No 31026505 hsa_circ_004518 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1351 No 31026505 hsa_circ_007131 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1352 No 31026505 hsa_circ_004347 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1353 No 31026505 hsa_circ_003361 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1354 No 31026505 hsa_circ_005678 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1355 No 31026505 hsa_circ_006892 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1356 No 31026505 hsa_circ_002458 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1357 No 31026505 hsa_circ_000991 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1358 No 31026505 hsa_circ_006701 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1359 No 31026505 hsa_circ_005091 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1360 No 31026505 hsa_circ_007238 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1361 No 31026505 hsa_circ_006404 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1362 No 31026505 hsa_circ_006486 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1363 No 31026505 hsa_circ_005013 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1364 No 31026505 hsa_circ_005449 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1366 No 31026505 hsa_circ_003243 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.657 No 31026505 hsa_circ_004766 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1367 No 31026505 hsa_circ_001735 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1368 No 31026505 hsa_circ_002280 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1369 No 31026505 hsa_circ_003194 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1370 No 31026505 hsa_circ_005826 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1371 No 31026505 hsa_circ_007117 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1372 No 31026505 hsa_circ_003316 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1373 No 31026505 hsa_circ_005773 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1374 No 31026505 hsa_circ_005792 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1375 No 31026505 hsa_circ_002300 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1376 No 31026505 hsa_circ_007273 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1377 No 31026505 hsa_circ_001491 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1378 No 31026505 hsa_circ_002077 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1379 No 31026505 hsa_circ_004911 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1380 No 31026505 hsa_circ_002596 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1350 No 31026505 hsa_circ_004188 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1349 No 31026505 hsa_circ_006164 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1348 No 31026505 hsa_circ_007266 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1347 No 31026505 hsa_circ_003706 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1318 No 31026505 hsa_circ_006618 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1319 No 31026505 hsa_circ_004825 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1320 No 31026505 hsa_circ_000495 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1321 No 31026505 hsa_circ_005406 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1322 No 31026505 hsa_circ_003823 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1323 No 31026505 hsa_circ_000894 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1324 No 31026505 hsa_circ_007052 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1325 No 31026505 hsa_circ_007044 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1326 No 31026505 hsa_circ_006652 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1327 No 31026505 hsa_circ_000072 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1328 No 31026505 hsa_circ_003734 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1329 No 31026505 hsa_circ_006924 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1330 No 31026505 hsa_circ_005807 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1331 No 31026505 hsa_circ_000347 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1332 No 31026505 hsa_circ_000177 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1333 No 31026505 hsa_circ_001937 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1334 No 31026505 hsa_circ_007142 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1335 No 31026505 hsa_circ_003572 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1336 No 31026505 hsa_circ_006969 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1337 No 31026505 hsa_circ_004142 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1338 No 31026505 hsa_circ_003831 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1339 No 31026505 hsa_circ_006273 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1340 No 31026505 hsa_circ_001455 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1341 No 31026505 hsa_circ_001021 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1342 No 31026505 hsa_circ_006382 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1343 No 31026505 hsa_circ_001481 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1344 No 31026505 hsa_circ_000533 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1345 No 31026505 hsa_circ_006715 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1346 No 31026505 hsa_circ_003903 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1381 No 31026505 hsa_circ_000468 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1382 No 31026505 hsa_circ_004100 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1383 No 31026505 hsa_circ_005633 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1416 No 31026505 hsa_circ_003221 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1418 No 31026505 hsa_circ_002494 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1419 No 31026505 hsa_circ_000061 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1420 No 31026505 hsa_circ_004822 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1421 No 31026505 hsa_circ_001414 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1422 No 31026505 hsa_circ_001419 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1423 No 31026505 hsa_circ_006398 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1424 No 31026505 hsa_circ_004476 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1425 No 31026505 hsa_circ_007138 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1426 No 31026505 hsa_circ_007108 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1427 No 31026505 hsa_circ_000610 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1428 No 31026505 hsa_circ_002931 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1429 No 31026505 hsa_circ_007155 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1430 No 31026505 hsa_circ_003562 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1431 No 31026505 hsa_circ_007082 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1432 No 31026505 hsa_circ_000805 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1433 No 31026505 hsa_circ_006747 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1434 No 31026505 hsa_circ_001567 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1435 No 31026505 hsa_circ_007104 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1436 No 31026505 hsa_circ_006483 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1437 No 31026505 hsa_circ_007043 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1438 No 31026505 hsa_circ_003923 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1439 No 31026505 hsa_circ_004292 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1440 No 31026505 hsa_circ_001574 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1441 No 31026505 hsa_circ_002079 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1442 No 31026505 hsa_circ_005858 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1443 No 31026505 hsa_circ_002702 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1444 No 31026505 hsa_circ_005768 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1445 No 31026505 hsa_circ_006615 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1446 No 31026505 hsa_circ_000359 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1417 No 31026505 hsa_circ_004009 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1415 No 31026505 hsa_circ_004996 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1384 No 31026505 hsa_circ_002810 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1414 No 31026505 hsa_circ_001480 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1385 No 31026505 hsa_circ_004807 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1386 No 31026505 hsa_circ_004794 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1387 No 31026505 hsa_circ_001614 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1388 No 31026505 hsa_circ_004973 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1389 No 31026505 hsa_circ_003079 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1390 No 31026505 hsa_circ_004692 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1391 No 31026505 hsa_circ_001235 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1392 No 31026505 hsa_circ_005933 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1393 No 31026505 hsa_circ_004086 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1394 No 31026505 hsa_circ_004842 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1395 No 31026505 hsa_circ_007132 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1396 No 31026505 hsa_circ_002890 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1397 No 31026505 hsa_circ_006874 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1398 No 31026505 hsa_circ_003014 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1399 No 31026505 hsa_circ_005342 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1400 No 31026505 hsa_circ_004516 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1401 No 31026505 hsa_circ_001148 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1402 No 31026505 hsa_circ_001763 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1403 No 31026505 hsa_circ_002809 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1404 No 31026505 hsa_circ_003855 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1405 No 31026505 hsa_circ_005089 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1406 No 31026505 hsa_circ_003074 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1407 No 31026505 hsa_circ_006743 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1408 No 31026505 hsa_circ_005043 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1409 No 31026505 hsa_circ_005407 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1410 No 31026505 hsa_circ_005631 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1411 No 31026505 hsa_circ_001116 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1412 No 31026505 hsa_circ_001969 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1413 No 31026505 hsa_circ_001942 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1317 No 31026505 hsa_circ_002620 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1316 No 31026505 hsa_circ_002833 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1315 No 31026505 hsa_circ_004839 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1217 No 31026505 hsa_circ_007042 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1219 No 31026505 hsa_circ_002574 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1220 No 31026505 hsa_circ_006721 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1221 No 31026505 hsa_circ_003309 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1222 No 31026505 hsa_circ_001460 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1223 No 31026505 hsa_circ_005806 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1224 No 31026505 hsa_circ_004985 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1225 No 31026505 hsa_circ_004980 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1226 No 31026505 hsa_circ_006601 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1227 No 31026505 hsa_circ_005323 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1228 No 31026505 hsa_circ_002770 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1229 No 31026505 hsa_circ_002717 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1230 No 31026505 hsa_circ_006795 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1231 No 31026505 hsa_circ_005639 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1232 No 31026505 hsa_circ_001377 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1233 No 31026505 hsa_circ_004433 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1234 No 31026505 hsa_circ_005696 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1235 No 31026505 hsa_circ_002667 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1236 No 31026505 hsa_circ_005370 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1237 No 31026505 hsa_circ_003190 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1238 No 31026505 hsa_circ_004065 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1239 No 31026505 hsa_circ_003756 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1240 No 31026505 hsa_circ_005251 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1241 No 31026505 hsa_circ_002619 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1242 No 31026505 hsa_circ_004381 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1243 No 31026505 hsa_circ_002636 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1244 No 31026505 hsa_circ_001544 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1245 No 31026505 hsa_circ_000658 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1246 No 31026505 hsa_circ_006699 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1247 No 31026505 hsa_circ_002273 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1218 No 31026505 hsa_circ_001327 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1216 No 31026505 hsa_circ_005712 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1249 No 31026505 hsa_circ_006545 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1215 No 31026505 hsa_circ_003637 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1186 No 31026505 hsa_circ_003826 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1187 No 31026505 hsa_circ_001018 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1188 No 31026505 hsa_circ_002753 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1189 No 31026505 hsa_circ_000574 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1190 No 31026505 hsa_circ_000886 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1191 No 31026505 hsa_circ_006651 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1192 No 31026505 hsa_circ_005665 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1193 No 31026505 hsa_circ_002052 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1194 No 31026505 hsa_circ_001796 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1195 No 31026505 hsa_circ_005868 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1196 No 31026505 hsa_circ_000048 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1197 No 31026505 hsa_circ_003487 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1198 No 31026505 hsa_circ_002464 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1199 No 31026505 hsa_circ_002091 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1200 No 31026505 hsa_circ_002504 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1201 No 31026505 hsa_circ_003167 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1202 No 31026505 hsa_circ_007195 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1203 No 31026505 hsa_circ_001357 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1204 No 31026505 hsa_circ_006700 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1205 No 31026505 hsa_circ_005272 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1206 No 31026505 hsa_circ_005361 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1207 No 31026505 hsa_circ_007192 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1208 No 31026505 hsa_circ_000474 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1209 No 31026505 hsa_circ_000747 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1210 No 31026505 hsa_circ_006704 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1211 No 31026505 hsa_circ_001232 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1212 No 31026505 hsa_circ_000424 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1213 No 31026505 hsa_circ_001667 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1214 No 31026505 hsa_circ_004976 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1248 No 31026505 hsa_circ_001407 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1250 No 31026505 hsa_circ_002651 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1314 No 31026505 hsa_circ_004144 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1283 No 31026505 hsa_circ_006081 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1285 No 31026505 hsa_circ_002930 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1286 No 31026505 hsa_circ_000913 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1287 No 31026505 hsa_circ_003807 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1288 No 31026505 hsa_circ_002778 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1289 No 31026505 hsa_circ_004096 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1290 No 31026505 hsa_circ_003434 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1291 No 31026505 hsa_circ_004338 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1292 No 31026505 hsa_circ_000425 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1293 No 31026505 hsa_circ_001249 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1294 No 31026505 hsa_circ_004598 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1295 No 31026505 hsa_circ_000550 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1296 No 31026505 hsa_circ_002150 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1297 No 31026505 hsa_circ_006220 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1298 No 31026505 hsa_circ_000335 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1299 No 31026505 hsa_circ_005840 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1300 No 31026505 hsa_circ_003523 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1301 No 31026505 hsa_circ_003479 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1302 No 31026505 hsa_circ_002170 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1303 No 31026505 hsa_circ_002593 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1304 No 31026505 hsa_circ_007127 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1305 No 31026505 hsa_circ_006872 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1306 No 31026505 hsa_circ_005239 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1307 No 31026505 hsa_circ_000739 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1308 No 31026505 hsa_circ_002845 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1309 No 31026505 hsa_circ_004917 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1310 No 31026505 hsa_circ_001540 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1311 No 31026505 hsa_circ_000767 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1312 No 31026505 hsa_circ_006041 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1313 No 31026505 hsa_circ_001545 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1284 No 31026505 hsa_circ_003667 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1282 No 31026505 hsa_circ_004975 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1251 No 31026505 hsa_circ_006972 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1281 No 31026505 hsa_circ_000500 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1252 No 31026505 hsa_circ_000434 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1253 No 31026505 hsa_circ_004746 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1254 No 31026505 hsa_circ_007061 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1255 No 31026505 hsa_circ_000433 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1256 No 31026505 hsa_circ_000701 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1257 No 31026505 hsa_circ_005722 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1258 No 31026505 hsa_circ_007109 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1259 No 31026505 hsa_circ_002572 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1260 No 31026505 hsa_circ_006996 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1261 No 31026505 hsa_circ_003568 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1262 No 31026505 hsa_circ_005179 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1263 No 31026505 hsa_circ_003632 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1264 No 31026505 hsa_circ_004408 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1265 No 31026505 hsa_circ_000288 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1266 No 31026505 hsa_circ_002679 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1267 No 31026505 hsa_circ_001197 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1268 No 31026505 hsa_circ_004735 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1269 No 31026505 hsa_circ_002394 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1270 No 31026505 hsa_circ_007237 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1271 No 31026505 hsa_circ_007229 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1272 No 31026505 hsa_circ_006797 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1273 No 31026505 hsa_circ_003218 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1274 No 31026505 hsa_circ_001797 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1275 No 31026505 hsa_circ_001905 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1276 No 31026505 hsa_circ_004267 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1277 No 31026505 hsa_circ_004237 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1278 No 31026505 hsa_circ_003314 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1279 No 31026505 hsa_circ_004168 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1280 No 31026505 hsa_circ_002145 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1447 No 31026505 hsa_circ_001620 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1448 No 31026505 hsa_circ_000586 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1449 No 31026505 hsa_circ_004965 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1614 No 31026505 hsa_circ_006735 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1616 No 31026505 hsa_circ_003463 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1617 No 31026505 hsa_circ_004166 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1618 No 31026505 hsa_circ_003661 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1619 No 31026505 hsa_circ_005831 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1620 No 31026505 hsa_circ_004091 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1621 No 31026505 hsa_circ_000444 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1622 No 31026505 hsa_circ_003000 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1623 No 31026505 hsa_circ_000006 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1624 No 31026505 hsa_circ_005499 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1625 No 31026505 hsa_circ_006882 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1626 No 31026505 hsa_circ_005747 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1627 No 31026505 hsa_circ_002276 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1628 No 31026505 hsa_circ_004415 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1629 No 31026505 hsa_circ_000494 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1630 No 31026505 hsa_circ_005802 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1631 No 31026505 hsa_circ_006071 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1632 No 31026505 hsa_circ_004614 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1633 No 31026505 hsa_circ_002696 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1634 No 31026505 hsa_circ_004014 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1635 No 31026505 hsa_circ_003433 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1636 No 31026505 hsa_circ_005636 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1637 No 31026505 hsa_circ_006094 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1638 No 31026505 hsa_circ_002050 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1639 No 31026505 hsa_circ_007139 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1640 No 31026505 hsa_circ_002095 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1641 No 31026505 hsa_circ_001978 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1642 No 31026505 hsa_circ_004178 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1643 No 31026505 hsa_circ_004592 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1644 No 31026505 hsa_circ_003752 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1615 No 31026505 hsa_circ_002462 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1613 No 31026505 hsa_circ_001968 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1646 No 31026505 hsa_circ_003041 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1612 No 31026505 hsa_circ_006359 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1583 No 31026505 hsa_circ_004074 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1584 No 31026505 hsa_circ_005171 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1585 No 31026505 hsa_circ_006982 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1586 No 31026505 hsa_circ_002048 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1587 No 31026505 hsa_circ_007173 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1588 No 31026505 hsa_circ_005343 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1589 No 31026505 hsa_circ_004519 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1590 No 31026505 hsa_circ_004761 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1591 No 31026505 hsa_circ_005845 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1592 No 31026505 hsa_circ_002614 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1593 No 31026505 hsa_circ_003883 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1594 No 31026505 hsa_circ_004958 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1595 No 31026505 hsa_circ_006997 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1596 No 31026505 hsa_circ_006560 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1597 No 31026505 hsa_circ_004821 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1598 No 31026505 hsa_circ_005476 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1599 No 31026505 hsa_circ_006955 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1600 No 31026505 hsa_circ_004325 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1601 No 31026505 hsa_circ_000704 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1602 No 31026505 hsa_circ_005168 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1603 No 31026505 hsa_circ_001643 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1604 No 31026505 hsa_circ_000144 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1605 No 31026505 hsa_circ_004752 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1606 No 31026505 hsa_circ_006061 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1607 No 31026505 hsa_circ_004967 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1608 No 31026505 hsa_circ_004947 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1609 No 31026505 hsa_circ_004361 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1610 No 31026505 hsa_circ_001586 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1611 No 31026505 hsa_circ_002582 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1645 No 31026505 hsa_circ_002676 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1647 No 31026505 hsa_circ_004131 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1581 No 31026505 hsa_circ_004884 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1680 No 31026505 hsa_circ_005184 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1682 No 31026505 hsa_circ_000023 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1683 No 31026505 hsa_circ_001726 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1684 No 31026505 hsa_circ_001559 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1685 No 31026505 hsa_circ_005045 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1686 No 31026505 hsa_circ_005138 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1687 No 31026505 hsa_circ_003030 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1688 No 31026505 hsa_circ_005642 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1689 No 31026505 hsa_circ_002922 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1690 No 31026505 hsa_circ_001401 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1691 No 31026505 hsa_circ_000266 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1692 No 31026505 hsa_circ_004942 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1693 No 31026505 hsa_circ_001020 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1694 No 31026505 hsa_circ_006478 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1695 No 31026505 hsa_circ_003156 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1696 No 31026505 hsa_circ_004582 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1697 No 31026505 hsa_circ_004829 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1698 No 31026505 hsa_circ_005119 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1699 No 31026505 hsa_circ_006855 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1700 No 31026505 hsa_circ_005931 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1701 No 31026505 hsa_circ_004351 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1702 No 31026505 hsa_circ_004627 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1703 No 31026505 hsa_circ_002332 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1704 No 31026505 hsa_circ_001787 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1705 No 31026505 hsa_circ_004963 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1706 No 31026505 hsa_circ_000686 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1707 No 31026505 hsa_circ_006994 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1708 No 31026505 hsa_circ_001724 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1709 No 31026505 hsa_circ_001952 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1710 No 31026505 hsa_circ_005423 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1681 No 31026505 hsa_circ_002357 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1679 No 31026505 hsa_circ_004581 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1648 No 31026505 hsa_circ_003612 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1678 No 31026505 hsa_circ_000045 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1649 No 31026505 hsa_circ_000058 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1650 No 31026505 hsa_circ_004294 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1651 No 31026505 hsa_circ_005637 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1652 No 31026505 hsa_circ_005483 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1653 No 31026505 hsa_circ_001201 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1654 No 31026505 hsa_circ_005974 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1655 No 31026505 hsa_circ_002443 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1656 No 31026505 hsa_circ_000729 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1657 No 31026505 hsa_circ_000140 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1658 No 31026505 hsa_circ_002480 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1659 No 31026505 hsa_circ_002349 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1660 No 31026505 hsa_circ_004950 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1661 No 31026505 hsa_circ_004848 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1662 No 31026505 hsa_circ_004176 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1663 No 31026505 hsa_circ_006113 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1664 No 31026505 hsa_circ_004681 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1665 No 31026505 hsa_circ_001904 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1666 No 31026505 hsa_circ_001516 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1667 No 31026505 hsa_circ_006661 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1668 No 31026505 hsa_circ_001665 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1669 No 31026505 hsa_circ_004222 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1670 No 31026505 hsa_circ_007319 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1671 No 31026505 hsa_circ_003862 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1672 No 31026505 hsa_circ_006888 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1673 No 31026505 hsa_circ_001985 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1674 No 31026505 hsa_circ_007118 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1675 No 31026505 hsa_circ_006233 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1676 No 31026505 hsa_circ_001069 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1677 No 31026505 hsa_circ_003104 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1582 No 31026505 hsa_circ_000418 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1580 No 31026505 hsa_circ_000825 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1450 No 31026505 hsa_circ_003896 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1482 No 31026505 hsa_circ_007119 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1484 No 31026505 hsa_circ_001853 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1485 No 31026505 hsa_circ_000972 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1486 No 31026505 hsa_circ_003322 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1487 No 31026505 hsa_circ_000243 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1488 No 31026505 hsa_circ_001057 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1489 No 31026505 hsa_circ_007129 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1490 No 31026505 hsa_circ_001228 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1491 No 31026505 hsa_circ_005385 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1492 No 31026505 hsa_circ_007227 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1493 No 31026505 hsa_circ_000679 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1494 No 31026505 hsa_circ_005940 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1495 No 31026505 hsa_circ_000336 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1496 No 31026505 hsa_circ_000257 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1497 No 31026505 hsa_circ_001666 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1498 No 31026505 hsa_circ_004550 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1499 No 31026505 hsa_circ_006702 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1500 No 31026505 hsa_circ_005049 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1501 No 31026505 hsa_circ_002054 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1502 No 31026505 hsa_circ_001600 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1503 No 31026505 hsa_circ_006165 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1504 No 31026505 hsa_circ_006722 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1505 No 31026505 hsa_circ_000214 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1506 No 31026505 hsa_circ_004358 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1507 No 31026505 hsa_circ_003292 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1508 No 31026505 hsa_circ_003338 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1509 No 31026505 hsa_circ_000851 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1510 No 31026505 hsa_circ_007030 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1511 No 31026505 hsa_circ_006456 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1512 No 31026505 hsa_circ_007126 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1483 No 31026505 hsa_circ_005810 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1481 No 31026505 hsa_circ_007306 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1514 No 31026505 hsa_circ_000577 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1480 No 31026505 hsa_circ_000882 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1451 No 31026505 hsa_circ_003117 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1452 No 31026505 hsa_circ_007125 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1453 No 31026505 hsa_circ_000134 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1454 No 31026505 hsa_circ_003810 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1455 No 31026505 hsa_circ_007078 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1456 No 31026505 hsa_circ_002908 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1457 No 31026505 hsa_circ_003353 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1458 No 31026505 hsa_circ_006144 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1459 No 31026505 hsa_circ_006250 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1460 No 31026505 hsa_circ_002680 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1461 No 31026505 hsa_circ_004844 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1462 No 31026505 hsa_circ_003854 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1463 No 31026505 hsa_circ_000823 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1464 No 31026505 hsa_circ_007172 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1465 No 31026505 hsa_circ_000816 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1466 No 31026505 hsa_circ_004322 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1467 No 31026505 hsa_circ_006709 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1468 No 31026505 hsa_circ_001618 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1469 No 31026505 hsa_circ_005896 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1470 No 31026505 hsa_circ_003486 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1471 No 31026505 hsa_circ_002395 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1472 No 31026505 hsa_circ_004400 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1473 No 31026505 hsa_circ_003224 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1474 No 31026505 hsa_circ_000693 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1475 No 31026505 hsa_circ_003853 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1476 No 31026505 hsa_circ_007083 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1477 No 31026505 hsa_circ_002669 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1478 No 31026505 hsa_circ_003332 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1479 No 31026505 hsa_circ_002891 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1513 No 31026505 hsa_circ_004667 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1515 No 31026505 hsa_circ_002763 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1579 No 31026505 hsa_circ_007143 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1548 No 31026505 hsa_circ_006137 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1550 No 31026505 hsa_circ_001064 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1551 No 31026505 hsa_circ_001066 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1552 No 31026505 hsa_circ_003180 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1553 No 31026505 hsa_circ_003234 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1554 No 31026505 hsa_circ_001433 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1555 No 31026505 hsa_circ_003987 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1556 No 31026505 hsa_circ_001674 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1557 No 31026505 hsa_circ_004952 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1558 No 31026505 hsa_circ_001175 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1559 No 31026505 hsa_circ_006980 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1560 No 31026505 hsa_circ_003856 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1561 No 31026505 hsa_circ_000399 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1562 No 31026505 hsa_circ_006332 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1563 No 31026505 hsa_circ_001062 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1564 No 31026505 hsa_circ_004945 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1565 No 31026505 hsa_circ_001879 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1566 No 31026505 hsa_circ_001101 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1567 No 31026505 hsa_circ_002868 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1568 No 31026505 hsa_circ_006723 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1569 No 31026505 hsa_circ_006724 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1570 No 31026505 hsa_circ_007240 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1571 No 31026505 hsa_circ_005936 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1572 No 31026505 hsa_circ_004956 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1573 No 31026505 hsa_circ_001698 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1574 No 31026505 hsa_circ_000616 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1575 No 31026505 hsa_circ_003956 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1576 No 31026505 hsa_circ_005913 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1577 No 31026505 hsa_circ_000287 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1578 No 31026505 hsa_circ_000352 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1549 No 31026505 hsa_circ_004268 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1547 No 31026505 hsa_circ_007141 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1516 No 31026505 hsa_circ_005209 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1546 No 31026505 hsa_circ_002583 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1517 No 31026505 hsa_circ_000062 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1518 No 31026505 hsa_circ_000501 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1519 No 31026505 hsa_circ_004852 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1520 No 31026505 hsa_circ_002892 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1521 No 31026505 hsa_circ_007309 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1522 No 31026505 hsa_circ_005764 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1523 No 31026505 hsa_circ_003185 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1524 No 31026505 hsa_circ_003220 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1525 No 31026505 hsa_circ_007330 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1526 No 31026505 hsa_circ_002796 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1527 No 31026505 hsa_circ_001507 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1528 No 31026505 hsa_circ_003941 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1529 No 31026505 hsa_circ_002259 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1530 No 31026505 hsa_circ_007146 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1531 No 31026505 hsa_circ_004560 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1532 No 31026505 hsa_circ_007196 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1533 No 31026505 hsa_circ_003275 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1534 No 31026505 hsa_circ_007145 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1535 No 31026505 hsa_circ_004959 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1536 No 31026505 hsa_circ_001053 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1537 No 31026505 hsa_circ_006536 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1538 No 31026505 hsa_circ_003620 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1539 No 31026505 hsa_circ_004615 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1540 No 31026505 hsa_circ_007239 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1541 No 31026505 hsa_circ_003328 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1542 No 31026505 hsa_circ_003329 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1543 No 31026505 hsa_circ_003024 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1544 No 31026505 hsa_circ_003083 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1545 No 31026505 hsa_circ_001403 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1185 No 31026505 hsa_circ_004904 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1184 No 31026505 hsa_circ_003050 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1183 No 31026505 hsa_circ_004543 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.821 No 31026505 hsa_circ_002190 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.823 No 31026505 hsa_circ_002314 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.824 No 31026505 hsa_circ_004972 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.825 No 31026505 hsa_circ_005362 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.826 No 31026505 hsa_circ_003662 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.827 No 31026505 hsa_circ_007137 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.828 No 31026505 hsa_circ_005676 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.829 No 31026505 hsa_circ_002869 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.830 No 31026505 hsa_circ_000300 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.831 No 31026505 hsa_circ_007252 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.832 No 31026505 hsa_circ_001157 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.833 No 31026505 hsa_circ_002785 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.834 No 31026505 hsa_circ_004994 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.835 No 31026505 hsa_circ_000242 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.836 No 31026505 hsa_circ_000544 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.837 No 31026505 hsa_circ_004250 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.838 No 31026505 hsa_circ_000461 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.839 No 31026505 hsa_circ_003864 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.840 No 31026505 hsa_circ_002447 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.841 No 31026505 hsa_circ_004805 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.842 No 31026505 hsa_circ_001373 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.843 No 31026505 hsa_circ_006264 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.844 No 31026505 hsa_circ_002446 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.845 No 31026505 hsa_circ_002486 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.846 No 31026505 hsa_circ_004382 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.847 No 31026505 hsa_circ_002107 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.848 No 31026505 hsa_circ_002571 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.849 No 31026505 hsa_circ_002634 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.850 No 31026505 hsa_circ_004843 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.851 No 31026505 hsa_circ_000005 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.822 No 31026505 hsa_circ_003366 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.820 No 31026505 hsa_circ_006648 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.853 No 31026505 hsa_circ_005615 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.819 No 31026505 hsa_circ_003850 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.790 No 31026505 hsa_circ_006010 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.791 No 31026505 hsa_circ_003517 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.792 No 31026505 hsa_circ_004937 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.793 No 31026505 hsa_circ_002678 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.794 No 31026505 hsa_circ_005368 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.795 No 31026505 hsa_circ_002081 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.796 No 31026505 hsa_circ_002038 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.797 No 31026505 hsa_circ_007091 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.798 No 31026505 hsa_circ_003993 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.799 No 31026505 hsa_circ_003252 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.800 No 31026505 hsa_circ_001816 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.801 No 31026505 hsa_circ_004146 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.802 No 31026505 hsa_circ_004229 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.803 No 31026505 hsa_circ_002078 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.804 No 31026505 hsa_circ_006794 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.805 No 31026505 hsa_circ_006792 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.806 No 31026505 hsa_circ_002575 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.807 No 31026505 hsa_circ_003367 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.808 No 31026505 hsa_circ_004132 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.809 No 31026505 hsa_circ_000695 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.810 No 31026505 hsa_circ_006793 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.811 No 31026505 hsa_circ_003973 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.812 No 31026505 hsa_circ_005757 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.813 No 31026505 hsa_circ_004702 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.814 No 31026505 hsa_circ_000620 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.815 No 31026505 hsa_circ_002928 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.816 No 31026505 hsa_circ_007270 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.817 No 31026505 hsa_circ_002929 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.818 No 31026505 hsa_circ_006877 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.852 No 31026505 hsa_circ_003966 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.854 No 31026505 hsa_circ_006894 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.788 No 31026505 hsa_circ_005419 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.887 No 31026505 hsa_circ_006752 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.889 No 31026505 hsa_circ_003015 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.890 No 31026505 hsa_circ_001599 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.891 No 31026505 hsa_circ_004568 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.892 No 31026505 hsa_circ_005238 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.893 No 31026505 hsa_circ_002111 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.894 No 31026505 hsa_circ_000082 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.895 No 31026505 hsa_circ_002933 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.896 No 31026505 hsa_circ_004378 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.897 No 31026505 hsa_circ_005783 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.898 No 31026505 hsa_circ_002035 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.899 No 31026505 hsa_circ_000971 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.900 No 31026505 hsa_circ_002415 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.901 No 31026505 hsa_circ_005223 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.902 No 31026505 hsa_circ_002782 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.903 No 31026505 hsa_circ_005134 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.904 No 31026505 hsa_circ_004260 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.905 No 31026505 hsa_circ_004486 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.906 No 31026505 hsa_circ_005224 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.907 No 31026505 hsa_circ_004789 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.908 No 31026505 hsa_circ_001547 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.909 No 31026505 hsa_circ_005127 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.910 No 31026505 hsa_circ_005760 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.911 No 31026505 hsa_circ_003543 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.912 No 31026505 hsa_circ_001034 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.913 No 31026505 hsa_circ_001849 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.914 No 31026505 hsa_circ_004380 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.915 No 31026505 hsa_circ_006300 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.916 No 31026505 hsa_circ_005677 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.917 No 31026505 hsa_circ_002080 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.888 No 31026505 hsa_circ_003323 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.886 No 31026505 hsa_circ_004717 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.855 No 31026505 hsa_circ_001454 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.885 No 31026505 hsa_circ_001740 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.856 No 31026505 hsa_circ_001741 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.857 No 31026505 hsa_circ_001561 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.858 No 31026505 hsa_circ_000928 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.859 No 31026505 hsa_circ_002704 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.860 No 31026505 hsa_circ_003213 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.861 No 31026505 hsa_circ_001186 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.862 No 31026505 hsa_circ_000106 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.863 No 31026505 hsa_circ_005256 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.864 No 31026505 hsa_circ_006989 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.865 No 31026505 hsa_circ_006102 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.866 No 31026505 hsa_circ_004986 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.867 No 31026505 hsa_circ_006390 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.868 No 31026505 hsa_circ_001983 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.869 No 31026505 hsa_circ_002815 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.870 No 31026505 hsa_circ_004438 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.871 No 31026505 hsa_circ_001605 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.872 No 31026505 hsa_circ_004981 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.873 No 31026505 hsa_circ_001465 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.874 No 31026505 hsa_circ_004983 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.875 No 31026505 hsa_circ_001734 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.876 No 31026505 hsa_circ_002277 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.877 No 31026505 hsa_circ_006092 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.878 No 31026505 hsa_circ_002463 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.879 No 31026505 hsa_circ_006988 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.880 No 31026505 hsa_circ_003429 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.881 No 31026505 hsa_circ_002727 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.882 No 31026505 hsa_circ_000806 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.883 No 31026505 hsa_circ_004677 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.884 No 31026505 hsa_circ_005856 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.789 No 31026505 hsa_circ_003228 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.787 No 31026505 hsa_circ_002177 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.919 No 31026505 hsa_circ_002830 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.689 No 31026505 hsa_circ_005090 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.691 No 31026505 hsa_circ_006535 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.692 No 31026505 hsa_circ_000074 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.693 No 31026505 hsa_circ_003749 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.694 No 31026505 hsa_circ_003576 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.695 No 31026505 hsa_circ_007304 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.696 No 31026505 hsa_circ_000762 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.697 No 31026505 hsa_circ_000543 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.698 No 31026505 hsa_circ_003394 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.699 No 31026505 hsa_circ_001019 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.700 No 31026505 hsa_circ_003980 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.701 No 31026505 hsa_circ_006395 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.702 No 31026505 hsa_circ_004228 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.703 No 31026505 hsa_circ_006414 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.704 No 31026505 hsa_circ_006021 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.705 No 31026505 hsa_circ_003969 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.706 No 31026505 hsa_circ_002848 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.707 No 31026505 hsa_circ_004721 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.708 No 31026505 hsa_circ_001910 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.709 No 31026505 hsa_circ_005822 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.710 No 31026505 hsa_circ_001779 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.711 No 31026505 hsa_circ_005544 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.712 No 31026505 hsa_circ_001780 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.713 No 31026505 hsa_circ_002877 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.714 No 31026505 hsa_circ_002425 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.715 No 31026505 hsa_circ_004251 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.716 No 31026505 hsa_circ_001262 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.717 No 31026505 hsa_circ_003955 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.718 No 31026505 hsa_circ_004435 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.719 No 31026505 hsa_circ_001832 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.690 No 31026505 hsa_circ_006726 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.688 No 31026505 hsa_circ_003626 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.721 No 31026505 hsa_circ_001753 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.687 No 31026505 hsa_circ_003375 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.658 No 31026505 hsa_circ_003445 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.659 No 31026505 hsa_circ_003372 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.660 No 31026505 hsa_circ_005681 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.661 No 31026505 hsa_circ_000332 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.662 No 31026505 hsa_circ_007261 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.663 No 31026505 hsa_circ_003392 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.664 No 31026505 hsa_circ_002674 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.665 No 31026505 hsa_circ_005705 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.666 No 31026505 hsa_circ_002444 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.667 No 31026505 hsa_circ_004699 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.668 No 31026505 hsa_circ_000192 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.669 No 31026505 hsa_circ_006627 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.670 No 31026505 hsa_circ_003737 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.671 No 31026505 hsa_circ_000368 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.672 No 31026505 hsa_circ_000755 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.673 No 31026505 hsa_circ_005808 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.674 No 31026505 hsa_circ_003524 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.675 No 31026505 hsa_circ_006949 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.676 No 31026505 hsa_circ_006948 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.677 No 31026505 hsa_circ_006369 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.678 No 31026505 hsa_circ_002381 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.679 No 31026505 hsa_circ_000328 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.680 No 31026505 hsa_circ_002004 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.681 No 31026505 hsa_circ_001137 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.682 No 31026505 hsa_circ_004931 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.683 No 31026505 hsa_circ_003105 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.684 No 31026505 hsa_circ_003824 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.685 No 31026505 hsa_circ_001752 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.686 No 31026505 hsa_circ_004777 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.720 No 31026505 hsa_circ_007286 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.722 No 31026505 hsa_circ_003187 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.786 No 31026505 hsa_circ_001809 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.755 No 31026505 hsa_circ_003901 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.757 No 31026505 hsa_circ_004025 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.758 No 31026505 hsa_circ_002950 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.759 No 31026505 hsa_circ_001111 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.760 No 31026505 hsa_circ_002958 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.761 No 31026505 hsa_circ_001110 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.762 No 31026505 hsa_circ_003507 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.763 No 31026505 hsa_circ_002775 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.764 No 31026505 hsa_circ_003569 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.765 No 31026505 hsa_circ_005001 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.766 No 31026505 hsa_circ_002189 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.767 No 31026505 hsa_circ_005861 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.768 No 31026505 hsa_circ_005195 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.769 No 31026505 hsa_circ_004728 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.770 No 31026505 hsa_circ_000842 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.771 No 31026505 hsa_circ_002320 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.772 No 31026505 hsa_circ_001812 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.773 No 31026505 hsa_circ_007128 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.774 No 31026505 hsa_circ_000406 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.775 No 31026505 hsa_circ_005334 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.776 No 31026505 hsa_circ_003339 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.777 No 31026505 hsa_circ_004334 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.778 No 31026505 hsa_circ_003566 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.779 No 31026505 hsa_circ_003432 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.780 No 31026505 hsa_circ_005934 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.781 No 31026505 hsa_circ_000378 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.782 No 31026505 hsa_circ_001582 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.783 No 31026505 hsa_circ_003317 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.784 No 31026505 hsa_circ_002291 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.785 No 31026505 hsa_circ_001302 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.756 No 31026505 hsa_circ_004804 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.754 No 31026505 hsa_circ_000094 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.723 No 31026505 hsa_circ_005777 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.753 No 31026505 hsa_circ_006373 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.724 No 31026505 hsa_circ_004687 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.725 No 31026505 hsa_circ_004608 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.726 No 31026505 hsa_circ_006768 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.727 No 31026505 hsa_circ_004436 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.728 No 31026505 hsa_circ_002814 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.729 No 31026505 hsa_circ_003567 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.730 No 31026505 hsa_circ_000538 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.731 No 31026505 hsa_circ_006267 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.732 No 31026505 hsa_circ_006714 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.733 No 31026505 hsa_circ_003531 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.734 No 31026505 hsa_circ_004849 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.735 No 31026505 hsa_circ_001303 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.736 No 31026505 hsa_circ_001100 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.737 No 31026505 hsa_circ_002331 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.738 No 31026505 hsa_circ_004321 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.739 No 31026505 hsa_circ_004199 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.740 No 31026505 hsa_circ_006272 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.741 No 31026505 hsa_circ_004645 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.742 No 31026505 hsa_circ_007280 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.743 No 31026505 hsa_circ_004913 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.744 No 31026505 hsa_circ_001541 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.745 No 31026505 hsa_circ_002823 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.746 No 31026505 hsa_circ_005726 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.747 No 31026505 hsa_circ_000337 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.748 No 31026505 hsa_circ_000435 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.749 No 31026505 hsa_circ_003359 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.750 No 31026505 hsa_circ_006839 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.751 No 31026505 hsa_circ_000105 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.752 No 31026505 hsa_circ_005608 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.918 No 31026505 hsa_circ_005517 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.920 No 31026505 hsa_circ_003212 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1182 No 31026505 hsa_circ_003197 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1085 No 31026505 hsa_circ_000948 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1087 No 31026505 hsa_circ_001158 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1088 No 31026505 hsa_circ_000772 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1089 No 31026505 hsa_circ_003278 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1090 No 31026505 hsa_circ_003315 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1091 No 31026505 hsa_circ_001464 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1092 No 31026505 hsa_circ_004657 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1093 No 31026505 hsa_circ_002492 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1094 No 31026505 hsa_circ_001808 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1095 No 31026505 hsa_circ_000536 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1096 No 31026505 hsa_circ_003103 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1097 No 31026505 hsa_circ_006013 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1098 No 31026505 hsa_circ_004239 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1099 No 31026505 hsa_circ_000821 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1100 No 31026505 hsa_circ_000879 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1101 No 31026505 hsa_circ_000402 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1102 No 31026505 hsa_circ_001350 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1103 No 31026505 hsa_circ_004926 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1104 No 31026505 hsa_circ_006985 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1105 No 31026505 hsa_circ_001141 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1106 No 31026505 hsa_circ_004988 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1107 No 31026505 hsa_circ_007112 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1108 No 31026505 hsa_circ_003867 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1109 No 31026505 hsa_circ_000584 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1110 No 31026505 hsa_circ_006770 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1111 No 31026505 hsa_circ_003186 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1112 No 31026505 hsa_circ_006716 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1113 No 31026505 hsa_circ_002356 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1114 No 31026505 hsa_circ_003159 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1115 No 31026505 hsa_circ_000524 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1086 No 31026505 hsa_circ_001626 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1084 No 31026505 hsa_circ_000215 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1117 No 31026505 hsa_circ_003401 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1083 No 31026505 hsa_circ_003630 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1054 No 31026505 hsa_circ_006944 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1055 No 31026505 hsa_circ_005666 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1056 No 31026505 hsa_circ_000098 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1057 No 31026505 hsa_circ_004922 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1058 No 31026505 hsa_circ_002926 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1059 No 31026505 hsa_circ_001947 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1060 No 31026505 hsa_circ_006442 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1061 No 31026505 hsa_circ_004141 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1062 No 31026505 hsa_circ_001459 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1063 No 31026505 hsa_circ_004753 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1064 No 31026505 hsa_circ_006836 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1065 No 31026505 hsa_circ_005673 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1066 No 31026505 hsa_circ_003291 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1067 No 31026505 hsa_circ_003081 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1068 No 31026505 hsa_circ_007210 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1069 No 31026505 hsa_circ_006292 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1070 No 31026505 hsa_circ_007231 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1071 No 31026505 hsa_circ_006606 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1072 No 31026505 hsa_circ_002990 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1073 No 31026505 hsa_circ_006005 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1074 No 31026505 hsa_circ_006226 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1075 No 31026505 hsa_circ_005827 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1076 No 31026505 hsa_circ_006004 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1077 No 31026505 hsa_circ_006605 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1078 No 31026505 hsa_circ_003106 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1079 No 31026505 hsa_circ_004225 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1080 No 31026505 hsa_circ_003851 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1081 No 31026505 hsa_circ_002099 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1082 No 31026505 hsa_circ_002863 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1116 No 31026505 hsa_circ_002124 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1118 No 31026505 hsa_circ_002155 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1052 No 31026505 hsa_circ_004564 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1151 No 31026505 hsa_circ_002491 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1153 No 31026505 hsa_circ_005439 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1154 No 31026505 hsa_circ_000427 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1155 No 31026505 hsa_circ_005366 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1156 No 31026505 hsa_circ_005365 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1157 No 31026505 hsa_circ_006365 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1158 No 31026505 hsa_circ_003260 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1159 No 31026505 hsa_circ_003882 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1160 No 31026505 hsa_circ_001310 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1161 No 31026505 hsa_circ_000880 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1162 No 31026505 hsa_circ_000579 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1163 No 31026505 hsa_circ_002956 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1164 No 31026505 hsa_circ_000462 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1165 No 31026505 hsa_circ_003812 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1166 No 31026505 hsa_circ_005628 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1167 No 31026505 hsa_circ_002359 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1168 No 31026505 hsa_circ_006767 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1169 No 31026505 hsa_circ_003269 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1170 No 31026505 hsa_circ_000650 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1171 No 31026505 hsa_circ_001583 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1172 No 31026505 hsa_circ_002910 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1173 No 31026505 hsa_circ_005713 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1174 No 31026505 hsa_circ_002957 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1175 No 31026505 hsa_circ_000212 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1176 No 31026505 hsa_circ_002524 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1177 No 31026505 hsa_circ_003358 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1178 No 31026505 hsa_circ_001790 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1179 No 31026505 hsa_circ_000700 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1180 No 31026505 hsa_circ_003525 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1181 No 31026505 hsa_circ_000914 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1152 No 31026505 hsa_circ_004563 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1150 No 31026505 hsa_circ_002272 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1119 No 31026505 hsa_circ_002666 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1149 No 31026505 hsa_circ_004434 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1120 No 31026505 hsa_circ_007008 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1121 No 31026505 hsa_circ_002271 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1122 No 31026505 hsa_circ_003468 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1123 No 31026505 hsa_circ_003246 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1124 No 31026505 hsa_circ_000737 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1125 No 31026505 hsa_circ_004778 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1126 No 31026505 hsa_circ_004895 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1127 No 31026505 hsa_circ_004332 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1128 No 31026505 hsa_circ_001305 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1129 No 31026505 hsa_circ_006378 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1130 No 31026505 hsa_circ_000674 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1131 No 31026505 hsa_circ_000132 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1132 No 31026505 hsa_circ_003348 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1133 No 31026505 hsa_circ_000213 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1134 No 31026505 hsa_circ_006160 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1135 No 31026505 hsa_circ_002901 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1136 No 31026505 hsa_circ_003692 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1137 No 31026505 hsa_circ_000632 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1138 No 31026505 hsa_circ_007120 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1139 No 31026505 hsa_circ_004449 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1140 No 31026505 hsa_circ_002489 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1141 No 31026505 hsa_circ_000077 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1142 No 31026505 hsa_circ_002752 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1143 No 31026505 hsa_circ_004397 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1144 No 31026505 hsa_circ_003633 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1145 No 31026505 hsa_circ_002671 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1146 No 31026505 hsa_circ_003796 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1147 No 31026505 hsa_circ_005316 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1148 No 31026505 hsa_circ_002766 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1053 No 31026505 hsa_circ_002825 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1051 No 31026505 hsa_circ_002880 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.921 No 31026505 hsa_circ_006744 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.953 No 31026505 hsa_circ_004167 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.955 No 31026505 hsa_circ_000598 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.956 No 31026505 hsa_circ_001015 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.957 No 31026505 hsa_circ_004345 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.958 No 31026505 hsa_circ_005786 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.959 No 31026505 hsa_circ_001409 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.960 No 31026505 hsa_circ_003465 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.961 No 31026505 hsa_circ_004835 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.962 No 31026505 hsa_circ_006225 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.963 No 31026505 hsa_circ_002937 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.964 No 31026505 hsa_circ_004346 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.965 No 31026505 hsa_circ_001676 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.966 No 31026505 hsa_circ_003464 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.967 No 31026505 hsa_circ_001675 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.968 No 31026505 hsa_circ_005294 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.969 No 31026505 hsa_circ_004136 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.970 No 31026505 hsa_circ_004707 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.971 No 31026505 hsa_circ_006358 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.972 No 31026505 hsa_circ_003334 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.973 No 31026505 hsa_circ_006653 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.974 No 31026505 hsa_circ_000559 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.975 No 31026505 hsa_circ_004990 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.976 No 31026505 hsa_circ_004982 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.977 No 31026505 hsa_circ_000343 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.978 No 31026505 hsa_circ_003753 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.979 No 31026505 hsa_circ_000626 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.980 No 31026505 hsa_circ_002302 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.981 No 31026505 hsa_circ_000035 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.982 No 31026505 hsa_circ_004861 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.983 No 31026505 hsa_circ_000756 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.954 No 31026505 hsa_circ_005028 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.952 No 31026505 hsa_circ_005664 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.985 No 31026505 hsa_circ_003344 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.951 No 31026505 hsa_circ_004310 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.922 No 31026505 hsa_circ_001061 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.923 No 31026505 hsa_circ_003073 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.924 No 31026505 hsa_circ_001063 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.925 No 31026505 hsa_circ_005198 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.926 No 31026505 hsa_circ_001940 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.927 No 31026505 hsa_circ_004271 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.928 No 31026505 hsa_circ_006022 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.929 No 31026505 hsa_circ_003320 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.930 No 31026505 hsa_circ_003426 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.931 No 31026505 hsa_circ_000988 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.932 No 31026505 hsa_circ_003961 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.933 No 31026505 hsa_circ_003724 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.934 No 31026505 hsa_circ_006303 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.935 No 31026505 hsa_circ_001775 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.936 No 31026505 hsa_circ_003110 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.937 No 31026505 hsa_circ_003627 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.938 No 31026505 hsa_circ_002176 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.939 No 31026505 hsa_circ_000862 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.940 No 31026505 hsa_circ_004081 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.941 No 31026505 hsa_circ_004487 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.942 No 31026505 hsa_circ_001628 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.943 No 31026505 hsa_circ_004719 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.944 No 31026505 hsa_circ_003609 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.945 No 31026505 hsa_circ_002988 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.946 No 31026505 hsa_circ_002451 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.947 No 31026505 hsa_circ_001533 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.948 No 31026505 hsa_circ_002661 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.949 No 31026505 hsa_circ_001833 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.950 No 31026505 hsa_circ_003023 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.984 No 31026505 hsa_circ_005661 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.986 No 31026505 hsa_circ_004039 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1050 No 31026505 hsa_circ_005899 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1019 No 31026505 hsa_circ_001411 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1021 No 31026505 hsa_circ_005458 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1022 No 31026505 hsa_circ_001854 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1023 No 31026505 hsa_circ_004524 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1024 No 31026505 hsa_circ_000642 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1025 No 31026505 hsa_circ_004213 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1026 No 31026505 hsa_circ_004277 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1027 No 31026505 hsa_circ_002420 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1028 No 31026505 hsa_circ_005982 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1029 No 31026505 hsa_circ_004940 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1030 No 31026505 hsa_circ_000889 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1031 No 31026505 hsa_circ_005860 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1032 No 31026505 hsa_circ_006245 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1033 No 31026505 hsa_circ_003096 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1034 No 31026505 hsa_circ_007178 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1035 No 31026505 hsa_circ_006142 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1036 No 31026505 hsa_circ_005116 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1037 No 31026505 hsa_circ_003615 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1038 No 31026505 hsa_circ_004567 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1039 No 31026505 hsa_circ_000768 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1040 No 31026505 hsa_circ_000656 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1041 No 31026505 hsa_circ_006941 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1042 No 31026505 hsa_circ_002611 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1043 No 31026505 hsa_circ_001972 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1044 No 31026505 hsa_circ_005720 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1045 No 31026505 hsa_circ_006655 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1046 No 31026505 hsa_circ_004906 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1047 No 31026505 hsa_circ_003355 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1048 No 31026505 hsa_circ_003614 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1049 No 31026505 hsa_circ_003333 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1020 No 31026505 hsa_circ_002708 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1018 No 31026505 hsa_circ_000311 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.987 No 31026505 hsa_circ_005318 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1017 No 31026505 hsa_circ_003526 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.988 No 31026505 hsa_circ_000636 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.989 No 31026505 hsa_circ_006565 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.990 No 31026505 hsa_circ_005782 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.991 No 31026505 hsa_circ_003528 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.992 No 31026505 hsa_circ_001389 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.993 No 31026505 hsa_circ_006654 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.994 No 31026505 hsa_circ_006480 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.995 No 31026505 hsa_circ_000774 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.996 No 31026505 hsa_circ_001133 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.997 No 31026505 hsa_circ_005026 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.998 No 31026505 hsa_circ_001390 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.999 No 31026505 hsa_circ_000049 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1000 No 31026505 hsa_circ_000685 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1001 No 31026505 hsa_circ_005832 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1002 No 31026505 hsa_circ_007251 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1003 No 31026505 hsa_circ_002792 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1004 No 31026505 hsa_circ_003504 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1005 No 31026505 hsa_circ_006407 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1006 No 31026505 hsa_circ_003312 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1007 No 31026505 hsa_circ_005980 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1008 No 31026505 hsa_circ_004233 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1009 No 31026505 hsa_circ_002777 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1010 No 31026505 hsa_circ_000141 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1011 No 31026505 hsa_circ_000661 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1012 No 31026505 hsa_circ_004590 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1013 No 31026505 hsa_circ_003794 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1014 No 31026505 hsa_circ_003712 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1015 No 31026505 hsa_circ_005459 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and normal ovarian tissues Expression[highly expressed] RNA-seq In total, 7333 circRNAs were identified, of which 2431 circRNAs were upregulated (red spots), and 3120 circRNAs were downregulated (green spots) with fold-changes ≥ 2 and p-value < 0.1016 No 31026505 hsa_circ_0070354 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tissues, cells, and serum of NSCLC Expression(highly expressed) qRT-PCR Hsa_circ_0070354 was highly expressed in tissues, cells, and serum of NSCLC, and it has the characteristics of sensitivity, stability, and repeatability. The ROC curve indicates that hsa_circ_0070354 is superior to conventional tumor markers in detecting NSCLC, and the combined diagnosis is of more significance in the diagnosis. The high expression of hsa_circ_0070354 is closely related to the late-stage, poor differentiation of the tumor and the short survival time of the patients, which is an independent indicator of poor prognosis. No 35096013 circTOLLIP CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Expression [lower expressed] qRT-PCR CircTOLLIP was screened as a candidate biomarker and was found to be significantly down-regulated in both NSCLC tissues and cell lines. Interestingly, circulating circTOLLIP was also lower-expressed in the whole blood of patients with NSCLC compared to that of patients with benign lung disease and healthy controls. No 34728180 HOTAIR LncRNA Homo sapiens Stomach Neoplasms GC cell lines Interaction(miR-200) qRT-PCR Our results showed significant increased miR-200 family expression level in transfected AGS and MKN45 GC cells (fold changes > 2; p < 0.001). Moreover, a negative correlation was observed between HOTAIR and miR-200 expression levels in GC cell lines (p < 0.05). No 34923813 DUXAP9 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Regulation[LINC01296/miR-26a/GALNT3 axis,PI3K/AKT pathway] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Differential expression of linc01296 is confirmed and closely correlated with the malignancy of CRC cell lines and poor clinical prognosis. These new findings indicate that linc01296/miR-26a/GALNT3 axis involves in the progression of CRC cells, illuminating the possible mechanism mediated by O-glycosylated MUC1 via PI3K/AKT pathway. No 30547804 EFNA1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR Levels of an lncRNA that we called gastric cancer metastasis associated long noncoding RNA (GMAN) were increased in gastric tumor tissues, compared with nontumor tissues; its up-regulation was associated with tumor metastasis and shorter survival times of patients. Levels of an lncRNA that we called gastric cancer metastasis associated long noncoding RNA (GMAN) were increased in gastric tumor tissues, compared with nontumor tissues; its up-regulation was associated with tumor metastasis and shorter survival times of patients. No 30445010 EFCAB6-DT-201 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[lower expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 13. No 31619123 EEF1A1P30 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 768 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 EDEM2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ECH1-212 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 EBLN3P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 EBF1-206 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 EBF1-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 EARS2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 E2F3P2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 997 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 DYM-206 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 DUXAP9-209 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 DUXAP9-206 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines Regulation[EGFR signaling] RNA Pull-Down//Western Blot//Wound Healing Assay//Co-IP//qRT-PCR//RIP//MTT//Transwell Assay Here, we report that a cytoplasmic lncRNA, DUXAP9-206 is overexpressed in NSCLC cells and closely related to NSCLC clinical features and poor patient survival. We reveal that DUXAP9-206 induced NSCLC cell proliferation and metastasis by directly interacting with Cbl-b, an E3 ubiquitin ligase, and reducing the degradation of epidermal growth factor receptor (EGFR) and thereby augmenting EGFR signaling in NSCLC. Notably, correlations between DUXAP9-206 and activated EGFR signaling were also validated in NSCLC patient specimens. Here, we report that a cytoplasmic lncRNA, DUXAP9-206 is overexpressed in NSCLC cells and closely related to NSCLC clinical features and poor patient survival. No 30515972 DUXAP9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DUXAP9 LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis In total, nine studies compromising 720 participants were enrolled in this analysis. The pooled results showed increased LINC01296 expression could predict unfavourable overall survival (OS) (HR = 1.89, 95%CI = 1.47-2.43, p < .001). Additionally, elevated LINC01296 expression was correlated with clinical stage (OR = 2.95, 95%CI = 2.13-4.08, p < .001), lymph node metastasis (OR = 2.76, 95%CI = 2.00-3.81, p < .001), tumour size (OR = 2.80, 95%CI = 1.77-4.41, p < .001), and tumour differentiation (OR = 2.11, 95%CI = 1.36-3.27, p < .001) in patients with cancers. No 31385542 chr4_25364505_25349492_-15013 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 246 were up-regulated and down-regulated, respectively. No 31843366 DUXAP9 LncRNA Homo sapiens Neuroblastoma Neuroblastoma tissues Expression[highly expressed] qRT-PCR//Microarray 765 differentially expressed lncRNAs were identified. LINC01296 was the most overexpressed lncRNA in advanced stage patients. RT-qPCR was conducted in 28 tumor tissues, confirming the tendency with microarray. Higher expression of LINC01296 was associated with age > 18 months (p = 0.004) and advanced stage (p = 0.021). 765 differentially expressed lncRNAs were identified. LINC01296 was the most overexpressed lncRNA in advanced stage patients. RT-qPCR was conducted in 28 tumor tissues, confirming the tendency with microarray. Higher expression of LINC01296 was associated with age > 18 months (p = 0.004) and advanced stage (p = 0.021). Furthermore, LINC01296 was correlated with tumor size (r = 0.4060, p = 0.0321), LDH level (r = 0.6904, p = 0.0002), and NSE level (r = 0.5772, p = 0.0013). The neuroblastoma dataset shows patients with overexpression of LINC01296 obtained a shorter overall survival than low expression (n = 88, log-rank: P < 0.0001). No 31522796 DUXAP9 LncRNA Homo sapiens Neuroblastoma NB tissues and cells Interaction(LINC01296-NCL-SOX11 ) In Vivo Experiment//Western Blot//qRT-PCR//FISH//RIP//migration assay//Cell Apoptosis Assay//Luciferase Report Assay//Cell Proliferation Assay//IHC//ChIP Results illuminated that LINC01296 expression was significantly correlated with unfavorable prognosis and malignant clinical features according to the public NB database. Mechanistically, we revealed that LINC01296 could directly bind to nucleolin (NCL), forming a complex that activated SRY-box transcription factor 11 (SOX11) gene transcription and accelerated tumor progression. In conclusion, our findings uncover a crucial role of the LINC01296-NCL-SOX11 complex in NB tumorigenesis and may serve as a prognostic biomarker and effective therapeutic target for NB. Results illuminated that LINC01296 expression was significantly correlated with unfavorable prognosis and malignant clinical features according to the public NB database. No 35317520 DUXAP8 LncRNA Homo sapiens Breast Neoplasms 71 luminal A and B tumor tissues and two luminal A cell lines Expression(highly expressed) qRT-PCR//Bioinformatics Analysis The results showed the significant upregulation of all three lncRNAs in luminal A and B tumor specimens and cell lines. Upregulation of DUXAP8 and FOXD2-AS1 was significantly associated with progesterone receptor-positive (PR+) and p53 protein expression in luminal BC patients, respectively. Based on bioinformatic analyses, DUXAP8 can be considered as a prognostic biomarker for patients with luminal BC. No 34043149 DUSP5P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DUSP10 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 Dubr-202 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[lower expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 15. No 30974198 DTX2P1-UPK3BP1-PMS2P11 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[highly expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 DTNB-219 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 DTL CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 DSG1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DSCR8 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Regulation[DSCR8/miR-485-5p/FZD7 axis] Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining In this study, real-time PCR in HCC tissues and cell lines indicated that DSCR8 expression was upregulated, while miR-485-5p was downregulated.Taken together, the present study reports for the first time that DSCR8 activates Wnt/β-catenin signal pathway to promote HCC progression by DSCR8/miR-485-5p/FZD7 axis. No 30154476 DSCAM-AS1 LncRNA Homo sapiens Breast Neoplasms paired cancerous tissue and adjacent non-neoplastic samples were obtained from fifty patients Expression [highly expressed] qRT-PCR Our results showed that the expression of DSCAM-AS1 was significantly up-regulated in breast cancerous tissues compared with the matched adjacent non-neoplastic tissues (P < 0.05). Furthermore, we observed a significant association between the DSCAM-AS1 expression and lymph node metastasis (P = 0.011) but no other clinicopathological characteristics (P > 0.05) No 33554879 DSCAM-AS1 LncRNA Homo sapiens colorectal adenocarcinoma CRA tissues Interaction[downregulates miR-216b] qRT-PCR//Transwell Assay//Western Blot It was observed that DSCAM-AS1 was upregulated in the primary tumor tissues than in paired non-tumor tissues (within 2 cm around tumors) and was further increased with tumor metastasis. miR-216b was downregulated in primary tumor and further downregulated with tumor metastasis. miR-216b was inversely correlated with DSCAM-AS1 in tumor tissues, but not in non-tumor tissues. In cells of CRA cell lines, DSCAM-AS1 overexpression resulted in the downregulation of miR-216b, while miR-216b overexpression did not significantly affect DSCAM-AS1. miR-216b inhibited cancer cell migration and invasion and significantly reduced the effects of DSCAM-AS1 overexpression. Methylation-specific PCR showed that DSCAM-AS1 overexpression promoted the methylation of miR-216b gene. No 31686837 DSCAM-AS1 LncRNA Homo sapiens invasive ductal carcinoma ANCTs tissues Expression[highly expressed] qRT-PCR DSCAM-AS1 was up-regulated in tumoral tissues compared with ANCTs (Fold change = 2.86, P = 0.011). No 30594914 EG00000259719 LncRNA Homo sapiens Dissection, Thoracic Aorta Human TAD (n=3) and normal aortic tissues (NA) (n=3) Expression [highly expressed] qRT-PCR//RNA-seq//Bioinformatics Analysis QRT-PCR results of five dysregulated genes were consistent with HTS data. A lncRNA-mRNA coexpression analysis showed positive correlations between the up-regulated lncRNA (ENSG00000269936) and its adjacent up-regulated mRNA (MAP2K6, R=0.940, P< 0.01), and between the down-regulated lncRNA_1421 and its down-regulated mRNAs (FBLN5, R=0.950, P< 0.01; ACTA2, R=0.96, P< 0.01; TIMP3, R=0.96, P< 0.05). The lncRNA-miRNA-mRNA network indicated that the up-regulated lncRNA XIST and p21 had similar sequences targeted by has-miR-17-5p. The results of luciferase assay and fluorescence immuno-cytochemistry were consistent with that. And qRT-PCR results showed that lncRNA XIST and p21 were expressed at a higher level and has-miR-17-5p was expressed at a lower level in TAD than in NA. The predicted binding motifs of three up-regulated lncRNAs (ENSG00000248508, ENSG00000226530, and EG00000259719) were correlated with up-regulated RUNX1 (R=0.982, P< 0.001; R=0.967, P< 0.01; R=0.960, P< 0.01, respectively). No 29669321 EGFR-AS1 LncRNA Homo sapiens Leiomyosarcoma LMS tissues Interaction(EGFR-AS1) In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//IHC//IF up-regulation of EGFR-AS1 and PD-L1 in LMS tissues was negatively correlated with CD8+ T-cell infiltration; EGFR-AS1 positively regulated PD-L1, thereby strengthening interaction of LMS cells and CD8+ T cells and triggering CD8+ T cell apoptosis via the PD-1/PD-L1 checkpoint; EGFR-AS1 co-localized and interacted with EGFR to promote MYC activity; MYC was identified as a transcriptional activator of PD-L1. No 35485964 EGFR-AS1 CircRNA Homo sapiens Colorectal Neoplasms CRC cases Expression(highly expressed) qRT-PCR Elevated circulating EGFR-AS1 levels were detected in CRC cases (n=128) compared with control cases comprising endoscopy confirmed CRC-free individuals [n=64, median expression normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH), 1.578 vs. 0.780, P<0.001]. Furthermore, the expression of EGFR-AS1 in resected CRC tissues was significantly higher than that in paracancerous tissues (n=32, 1.336 vs. 0.487, P<0.001). Individuals with larger tumors (≥5 cm) had elevated circulating EGFR-AS1 levels compared to those with smaller tumors (<5 cm, 1.739 vs. 1.290, P<0.001). The expression of serum EGFR-AS1 in stage III/IV CRC was higher than that in stage I/II CRC (1.691 vs. 1.412, P<0.05). Plasma EGFR-AS1 levels were markedly reduced following surgical resection of colorectal lesions in a subset of patients [n=32, 1.192 (pre-surgery) vs. 0.692, P<0.001]. No 36388668 EGOT LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ENSG00000226530 LncRNA Homo sapiens Dissection, Thoracic Aorta Human TAD (n=3) and normal aortic tissues (NA) (n=3) Expression [highly expressed] qRT-PCR//RNA-seq//Bioinformatics Analysis QRT-PCR results of five dysregulated genes were consistent with HTS data. A lncRNA-mRNA coexpression analysis showed positive correlations between the up-regulated lncRNA (ENSG00000269936) and its adjacent up-regulated mRNA (MAP2K6, R=0.940, P< 0.01), and between the down-regulated lncRNA_1421 and its down-regulated mRNAs (FBLN5, R=0.950, P< 0.01; ACTA2, R=0.96, P< 0.01; TIMP3, R=0.96, P< 0.05). The lncRNA-miRNA-mRNA network indicated that the up-regulated lncRNA XIST and p21 had similar sequences targeted by has-miR-17-5p. The results of luciferase assay and fluorescence immuno-cytochemistry were consistent with that. And qRT-PCR results showed that lncRNA XIST and p21 were expressed at a higher level and has-miR-17-5p was expressed at a lower level in TAD than in NA. The predicted binding motifs of three up-regulated lncRNAs (ENSG00000248508, ENSG00000226530, and EG00000259719) were correlated with up-regulated RUNX1 (R=0.982, P< 0.001; R=0.967, P< 0.01; R=0.960, P< 0.01, respectively). No 29669321 ENSG00000223486 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 ENSG00000214970.3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] Microarray Moreover, the intersection analysis between 130 gene symbols and 73 gene symbols showed a total of nine miRNAs, and the number of targeted lncRNA was 11, which served as the differentially expressed lncRNA (Table 1). No 35117179 ENPP7P4 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 795 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 EMX2OS LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 EMX2OS LncRNA Homo sapiens Fatigue Syndrome, Chronic peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR LncRNAs NTT, MIAT and EmX2OS levels were found to be significantly elevated in ME/CFS patients as compared with healthy controls. No 30119681 EMC3-AS1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 769 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 EMBP1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 990 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ELOVL1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ELOCP19 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 638 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ELMO1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR We uncovered that ELMO1-AS1 was significantly downregulated in HCC tissues, and high expression of ELMO1-AS1 is correlated with optimistic treatment outcome suggesting its potential as an independent prognostic biomarker for HCC. We uncovered that ELMO1-AS1 was significantly downregulated in HCC tissues, and high expression of ELMO1-AS1 is correlated with optimistic treatment outcome suggesting its potential as an independent prognostic biomarker for HCC. No 31498334 ELK2AP LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ELF3-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression(highly expressed) qRT-PCR High expression of ELF3-AS1 in patients with HCC was related to T stage (P < 0.001), gender (P = 0.006), residual tumor (P = 0.008), histologic grade (P < 0.001), adjacent hepatic tissue inflammation (P = 0.011), AFP (P < 0.001), and vascular invasion (P = 0.028). High expression of ELF3-AS1 in patients with HCC was related to T stage (P < 0.001), gender (P = 0.006), residual tumor (P = 0.008), histologic grade (P < 0.001), adjacent hepatic tissue inflammation (P = 0.011), AFP (P < 0.001), and vascular invasion (P = 0.028). No 34336727 ELF3-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular Regulation Survival Analysis Classification analysis developed a three-lncRNA signature of AC005332.5, ELF3-AS1 and LINC00665, which was demonstrated to be the most discriminatory with an AUC (Area under the curve) value of 0.913 (95% CI: 0.8610-0.9665) and verified in validation patients. The expression levels of AC005332.5, ELF3-AS1 and LINC00665 were significantly changed with different tumor stages or grades. Survival analysis revealed that AC005332.5, ELF3-AS1 and LINC00665 were highly associated with the prognosis of overall survival. Additionally, the lncRNA signature yielded statistical significance to predict clinical outcomes independently from other clinical variables in validation patients, as suggested in the multivariate Cox hazards analysis. Conclusively, a three-lncRNA signature of AC005332.5, ELF3-AS1 and LINC00665 may serve as an excellent diagnostic biomarker for HBV-related HCC and potential prognostic significance for HBV-related HCC sufferers. Classification analysis developed a three-lncRNA signature of AC005332.5, ELF3-AS1 and LINC00665, which was demonstrated to be the most discriminatory with an AUC (Area under the curve) value of 0.913 (95% CI: 0.8610-0.9665) and verified in validation patients.The expression levels of AC005332.5, ELF3-AS1 and LINC00665 were significantly changed with different tumor stages or grades.Survival analysis revealed that AC005332.5, ELF3-AS1 and LINC00665 were highly associated with the prognosis of overall survival. Additionally, the lncRNA signature yielded statistical significance to predict clinical outcomes independently from other clinical variables in validation patients, as suggested in the multivariate Cox hazards analysis No 35802466 ELDR LncRNA Homo sapiens Breast Neoplasms serum of BC patients and healthy subjects Expression [lower expressed] RNA-seq After a comprehensive comparison of the BC patients and healthy subjects, we discovered five up-regulated exo-lncRNAs and six down-regulated exo-lncRNAs of interest. No 34733934 EIF6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 EIF4H-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 EIF4EBP2P2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1005 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 EIF4A2-222 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 EIF4A2-219 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 EIF3J-DT LncRNA Homo sapiens Glioma glioma cell lines regulation[EIF3J-AS1/miR-1343-3p/ANXA11 axis ] RNA Pull-Down//Tunel//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining EIF3J-AS1 was overexpressed in glioma cell lines. EIF3J-AS1/miR-1343-3p/ANXA11 axis significantly affected biological behaviors in glioma, suggesting new therapeutic target for glioma treatment. No 32905397 EIF3D-205 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 EIF3A-202 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 EIF2S2P6 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 583 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 EIF1P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1084 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 EIF1B-204 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 EHMT1-243 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 EHMT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 EHBP1L1-202 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 DSCAM-AS1 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[highly expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 DSCAM-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR DSCAM-AS1 and MANCR lncRNAs were significantly upregulated in BC tumor tissues compared with the adjacent nontumor tissues. We also found the significant upregulation of DSCAM-AS1 in advanced tumor-node-metastasis stage (TNM III) of BC tumor tissues. No 33012018 DNAH17-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DNA2 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 DMTN LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)61) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 DMGDH LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DMBT1L1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DLX6-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Regulation[DLX6-AS1/miR-129-5p/DLK1 axis] qRT-PCR High DLX6-AS1 expression was observed in osteosarcoma tissues, and predicted a poor prognosis for osteosarcoma patients. Our study suggests that DLX6-AS1, combined with miR-129-5p and DLK1, can be utilized as factors for the clinical diagnosis and prognosis of osteosarcoma, and may be potential targets for the treatment of osteosarcoma. High DLX6-AS1 expression was observed in osteosarcoma tissues, and predicted a poor prognosis for osteosarcoma patients. No 30442366 DLX6-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms Serum exosomal Expression(highly expressed) qRT-PCR//Western Blot Serum exosomal lncRNA DLX6-AS1 level was significantly elevated in CC patients compared with CIN patients and normal controls. In addition, high serum exosomal lncRNA DLX6-AS1 expression was positively associated with lymph node metastasis, differentiation, FIGO stage, and shortened survival. Patients with high serum exosomal lncRNA DLX6-AS1 expression were more prone to have a relapse. No 33550924 DLGAP1-AS2 LncRNA Homo sapiens Stomach Neoplasms GC samples Expression(highly expressed) qRT-PCR Consistent with data obtained from GEO datasets, qRT-PCR results revealed that DLGAP1-AS2 was significantly (p < 0.0032) upregulated in GC specimens compared to normal samples, which was additionally confirmed using TCGA analysis (p < 0.0001). DLGAP1-AS2 expression level was also correlated with age (p = 0.0008), lymphatic and vascular invasion (p = 0.0415) in internal samples as well as poor survival of GC patients (p = 0.00074) in GEO datasets. No 34981339 DLGAP1-AS2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1079 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 DLGAP1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cell lines regulation[miR-26a/b-5p/IL-6/JAK2/STAT3 and Wnt/β-catenin pathway] RNA Pull-Down//Western Blot//Wound Healing Assay//Tunel//CCK8//qRT-PCR//RIP//Luciferase Report Assay//ELISA//ChIP In our study, DLGAP1-AS1 was shown to be upregulated in HCC cell lines and capable to promote HCC progression and EMT. Moreover, we elaborated that the cancerogenic effects of DLGAP1-AS1 in HCC cells could be effectuated via activating Wnt/β-catenin pathway by positively regulating CDK8 and LRP6, downstream genes of miR-26a/b-5p. No 31949128 DLGAP0 CircRNA Homo sapiens Ischemic Stroke blood Interaction[miR-143] ELISA//qPCR//PCR PBMC circ-DLGAP4 was down-regulated in AIS patients compared with controls, and ROC curve analysis disclosed that PBMC circ-DLGAP expression had good value in predicting lower AIS risk with area under curve 0.816.Circulating circ-DLGAP4 could serve as a novel biomarker for diagnosis and disease surveillance of AIS and is negatively correlated with inflammation and miR-143 expression in AIS patients. PBMC circ-DLGAP4 was down-regulated in AIS patients compared with controls, and ROC curve analysis disclosed that PBMC circ-DLGAP expression had good value in predicting lower AIS risk with area under curve 0.816. Spearman's rank correlation test showed that PBMC circ-DLGAP4 expression negatively correlated with NIHSS score and CRP level in AIS patients. No 31933904 DLG2-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissue Expression[lower expressed] qRT-PCR On an RT-qPCR survey of 90 cancer-related lncRNAs, we found one lncRNA, DLG2-AS1, which was consistently downregulated in 70 LUAD patients. No 32731343 DLEU7-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML samples Expression(lower expressed) qRT-PCR In our PCR validation, DLEU7-AS1 expression was significantly decreased in the AML samples compared with that in controls (P<0.001). Low DLEU7-AS1 expression (DLEU7-AS1low) correlated positively with lower blood platelet counts (P=0.029). In addition, low DLEU7-AS1 expression was more frequently observed in the intermediate (58%; 44/76) and favorable karyotypes (65%; 15/23) compared with that in the poor karyotype (10%; 1/10; P=0.005). In particular, patients with high expression levels of DLEU7-AS1 (DLEU7-AS1high) showed lower complete remission rates (P=0.002) than patients with DLEU7-AS1low. Survival analysis revealed that patients with DLEU7-AS1low had longer overall survival (OS) than patients with DLEU7-AS1high (P<0.05). Low DLEU7-AS1 expression (DLEU7-AS1low) correlated positively with lower blood platelet counts (P=0.029). In addition, low DLEU7-AS1 expression was more frequently observed in the intermediate (58%; 44/76) and favorable karyotypes (65%; 15/23) compared with that in the poor karyotype (10%; 1/10; P=0.005). In particular, patients with high expression levels of DLEU7-AS1 (DLEU7-AS1high) showed lower complete remission rates (P=0.002) than patients with DLEU7-AS1low. Survival analysis revealed that patients with DLEU7-AS1low had longer overall survival (OS) than patients with DLEU7-AS1high (P<0.05). No 35506368 DLEU2L LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 Dleu2-202 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[lower expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 17. No 30974198 DLEU2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC samples Expression [highly expressed] CCK8//qRT-PCR//Flow Cytometry//Western Blot Clinically, we revealed that LINC00022 was up-regulated in primary ESCC samples and was predictive of poor clinical outcome for ESCC patients. Mechanistically, LINC00022 directly binds to p21 protein and promotes its ubiquitination-mediated degradation, thereby facilitating cell-cycle progression and proliferation. No 34544449 DLEU2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DLEU2 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 DLEU2 LncRNA Homo sapiens Endometrial Neoplasms EC tissues Interaction(miR-455/EZH2/miR-181a pathway) qRT-PCR Furthermore, DLEU2 displayed a significantly higher expression in EC tissues, and increased DLEU2 expression was correlated with worse overall survival. DLEU2 acted as an upstream activator for HK2-induced EMT and glycolysis in EC cells through two distinct mechanisms: (i) DLEU2 induced HK2 expression by competitively binding with miR-455, and (ii) DLEU2 also interacted with EZH2 to silence a direct inhibitor of HK2, miR-181a. Furthermore, DLEU2 displayed a significantly higher expression in EC tissues, and increased DLEU2 expression was correlated with worse overall survival. No 34174908 DLEU2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 DLEU2 LncRNA Homo sapiens COVID-19 mild and severe COVID-19 patients Regulation Bioinformatics Analysis Interestingly we found six lncRNAs (TALAM1, DLEU2, and UICLM CASC18, SNHG20, and GNAS) involved in the protein-coding DEG-lncRNA network; which might be served as potential biomarkers for COVID-19 patients. No 34975833 DLEU1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC and matched adjacent non-tumor lung tissues Expression[highly expressed] qRT-PCR//Microarray FENDRR-005 and LINC00968-007 were downregulated in NSCLC compared with matched adjacent normal tissues, and DLEU1 and LINC01615 were upregulated in NSCLC compared with matched adjacent normal tissues. No 31348244 DLEU1 LncRNA Homo sapiens Glioblastoma GBM tissues Expression[highly expressed] qRT-PCR RT‑PCR demonstrated that the expression levels of DLEU1 and TRAF4 were increased in GBM tissues. No 31257517 DLEU1 LncRNA Homo sapiens Glioblastoma glioblastoma tissue and cells Expression[highly expressed] qRT-PCR Clinically, lncRNA LINC00021 was significantly up-regulated in glioblastoma, especially the TMZ-resistant tissue and cells, and the LINC00021 overexpression was closely correlated to TMZ resistance and unfavorable prognosis. Clinically, lncRNA LINC00021 was significantly up-regulated in glioblastoma, especially the TMZ-resistant tissue and cells, and the LINC00021 overexpression was closely correlated to TMZ resistance and unfavorable prognosis. No 32449315 DLEU1 LncRNA Homo sapiens Endometrial Neoplasms blood Expression[highly expressed] qRT-PCR Our results demonstrated that serum lncRNA DLEU1 levels were significantly increased in patients with EC, and serum lncRNA DLEU1 showed good performance for discriminating EC patients from patients with endometrial hyperplasia and healthy controls. Moreover, EC patients in the high serum lncRNA DLEU1 group suffered worse overall survival and disease-free survival than those in the low serum lncRNA DLEU1 group. No 33327893 DLEU1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Expression(highly expressed) qRT-PCR//Bioinformatics Analysis The results indicated that DLEU1 expression was significantly upregulated in CC tissues and cell lines, particularly in those that were HPV+. In addition, DLEU1 had a high diagnostic value in discriminating patients with CC and differentiating between HPV+ and HPV- patients with CC, and had a certain ability to screen HPV+ controls. DLEU1 was correlated with HPV infection in CC patients. Furthermore, DLEU1 was indicated to be associated with survival prognosis in both total patients with CC and HPV+ patients with CC, and independently predict the prognosis of patients with CC. No 35014679 DKC1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DISC2 LncRNA Homo sapiens Bipolar Disorder blood Expression[highly expressed] qRT-PCR Significant down-regulation of DISC1 and up-regulation of DISC2 were observed in BD cases compared with controls. No 30599263 DISC1 LncRNA Homo sapiens Bipolar Disorder blood Expression[lower expressed] qRT-PCR Significant down-regulation of DISC1 and up-regulation of DISC2 were observed in BD cases compared with controls. No 30599263 DIS3L2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DNAAF5 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DNAJC3-DT LncRNA Homo sapiens Leukemia, Myeloid, Acute AML patients Interaction(MiR-140) BrdU//qRT-PCR Increased expression levels of DNAJC3-AS1 and decreased expression levels of miR-140 were observed in AML patients. DNAJC3-AS1 was detected in nuclear and cytoplasm samples and direct interaction between DNAJC3-AS1 and miR-140 was observed. No 35070212 DSCAM LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DNAJC5B-202 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 DROSHA CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 DRG1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 DRAIC LncRNA Homo sapiens Breast Neoplasms tumor tissues Expression[highly expressed] qRT-PCR Its expression is elevated in tumor tissues compared to adjacent benign tissues in breast cancer patients and is regulated by estrogen treatment in breast cancer cells. No 30544991 DRAIC LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 DQ600483 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)21) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 DQ596229 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[highly expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 DQ595787 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[lower expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 DQ590126 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[lower expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 DQ589437 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[highly expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 DQ579288 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[lower expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 DQ576791 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[lower expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 DQ576039 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[lower expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 DPYD-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DPY19L1P1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 DPY19L1P1 LncRNA Homo sapiens Meningitis, Cryptococcal blood Expression[highly expressed] qRT-PCR LncRNA-DPY19L1p1 was significantly increased in patients and decreased after treatment. No 30767376 DPP10-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression [lower expressed] qRT-PCR QRTBC032913 expression was downregulated in cancerous tissues as compared with adjacent non-tumorous tissues (P = 0.0108). Downregulation of BC032913 expression did not demonstrate a significant association with clinicopathological parameters. No 32914372 DOP1B CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 DOCK9-DT LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DOCK9-DT LncRNA Homo sapiens Endometrial Neoplasms 301 UCEC patients Regulation Bioinformatics Analysis We detected a novel lncRNA-focus expression signature (LFES) consisting of 11 lncRNAs that were associated with survival based on risk scoring strategy in UCEC. The risk score based on the LFES was able to separate patients of discovery cohort into high-risk and low-risk groups with significantly different overall survival and progression-free survival, and has been successfully confirmed in the validation cohort. No 29304762 DNMT3A LncRNA Homo sapiens Urinary Bladder Neoplasms MIBCs Interaction(DNMT3A/ miR-129-2-5p/Rac1) RNA Pull-Down//Transfection//RIP//qRT-PCR//Luciferase Report Assay//cell invasion assay//ChIP Our data strongly suggest that the SNHG1/DNMT3A/miR-129-2-5p/Rac1 effector pathway drives stem-cell-like and invasive behaviors in MIBC, a deadly form of bladder cancer. No 36077697 DNM3OS-201 LncRNA Homo sapiens Adrenocortical Carcinoma ACC tissues Expression[lower expressed] qRT-PCR//Microarray In these samples, 874 lncRNAs were differentially expressed in ACC compared with NAC, of which 409 were upregulated, and 465 were downregulated. The 874 differentially expressed lncRNAs corresponded to 330 annotated lncRNA genes. Among the upregulated lncRNAs, the greatest log2 fold change was 8.5 for an unannotated lncRNA gene, and RAD50 was the geratest upregulated, annotated lncRNA gene with a log2 fold change of 6.1. Among the downregulated lncRNAs, the greatest log2 fold change was 8.3 for an unannotated lncRNA gene and 6.4 for HAND2, the greatest downregulated annotated lncRNA gene; of these, 183 differently expressed lncRNAs had established functions in cancer development and cancer progression. Selected carcinogenesis-related lncRNAs are summarized in Table 2. No 31522749 DNM3OS LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues,cell lines Expression[highly expressed] Western Blot//ISH//qRT-PCR//Luciferase Report Assay//IF Among the 38 lncRNAs tested, DNM3OS was found to have a much higher expression level in esophageal cancer cells than in Het-1A. In tumor tissues of 16 patients with ESCC, the expression level of DNM3OS showed an average increase of 6.3429-fold compared with that in matched normal tissues. No 30463848 DNM3OS LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DNM1P41 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DNLZ LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DNAJC9-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 DNAJC8-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 DNAJC8-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 DNAJC6 CircRNA Homo sapiens Cardiomyopathy, Hypertrophic blood Expression[lower expressed] qRT-PCR Serum expression levels of circRNAs DNAJC6, TMEM56 and MBOAT2 were downregulated in patients with HCM. No 31889077 ENSG00000228613.1 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 ENSG00000230971 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 ENSG00000243039 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 EPB41L4A-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 EPB41-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 EOLA2-DT LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 865 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 EOLA1-DT LncRNA Homo sapiens Breast Neoplasms TCGA(1,104 tumor samples and 292 normal samples) Regulation Bioinformatics Analysis In total, five metabolism-related lncRNAs were enrolled to establish prognostic signatures. Further analysis demonstrated that the signature was an independent prognostic factor for BC. No 34254565 EOLA1-DT LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 884 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ENST00000634344 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[highly expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 8. No 31619123 ENST00000622757 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[lower expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 17. No 31619123 ENST00000620769 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[lower expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 16. No 31619123 ENST00000620513 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ENST00000616344 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ENST00000614187 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 ENST00000613309 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[lower expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 15. No 31619123 ENST00000610659 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 ENST00000609755.1 LncRNA Homo sapiens Coronary Disease 5 CHD and 5 healthy controls Interaction( miR-150 and ELK1) qRT-PCR//Microarray qRT-PCR results suggest that the expression of lncRNA ENST00000609755.1 and ELK1 were up-regulated in CHD group and positively correlated, the expression of miR-150 was down-regulated in CHD, which was negatively correlated with lncRNA ENST00000609755.1 and ELK1. No 33279591 ENST00000609755 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[lower expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 ENST00000609522.1 LncRNA Homo sapiens Diabetes Mellitus, Type 2 five patients with T2D and paired controls (lower expressed) qRT-PCR//Bioinformatics Analysis//Microarray The top five upregulated lncRNAs are ENST00000381108.3, ENST00000515544.1, ENST00000539543.1, ENST00000508174.1, and ENST00000564527.1, and the top five downregulated lncRNAs are TCONS_00017539, ENST00000430816.1, ENST00000533203.1, ENST00000609522.1, and ENST00000417079.1. No 35257412 ENST00000607876 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[highly expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 ENST00000606664 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[lower expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 ENST00000604533 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[lower expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 14. No 31619123 ENST00000603415 LncRNA Homo sapiens Arthritis, Rheumatoid peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR The expression levels of NR_002819, NR_038935, and ENST00000603415 were significantly increased in the RA-ILD group, while the expression level of ENST00000560199 was significantly decreased. No 32133566 ENST00000595383 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ENST00000589524.1 LncRNA Homo sapiens Cardiovascular Diseases blood Expression[highly expressed] qRT-PCR//Microarray To validate the microarray data, four up-regulated lncRNAs (NR_037652.1, ENST00000607654.1, ENST00000589524.1 and uc004bhb.3) were selected based on the functional co-expression networks, the signal value and the validation of designed primers. A description of the four strictly screened lncRNAs is presented in Table 5. The four lncRNAs were all up-regulated between 50 Uyghur SAP patients and 50 matched controls, which were consistent with the microarray data (Figure 8). The characteristics of the 100 validated participants are shown in Table 6. For an in-depth understanding of the four lncRNAs, the target genes are mainly based on correlation of at least 0.8, not only the possible function (Supplementary Figure S1). No 31413167 ENST00000588803 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck plasma of 28 cases with TNM I/II [early-stage squamous cell carcinoma (ESCC) group], 36 cases with TNM III/IV [advanced-stage squamous cell carcinoma (ASCC) group], 16 cases with dysplasia [oral premalignant lesion (OPL) group] and 16 healthy controls (H group) Regulation qRT-PCR//Microarray The expression level of ENST00000412740, NR_131012, ENST00000588803 and NR_038323 exhibited significant differences in the H, OPL, ESCC and ASCC groups (P<0.05). ROC curve and logistic regression analyses revealed that the diagnostic efficacy of the combined lncRNAs was more prominent than that of a single lncRNA, particularly in the ESCC and ASCC groups. No 33552289 ENST00000587267 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ENST00000585798 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[lower expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 19. No 31619123 ENST00000585559 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[highly expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 11. No 31619123 ENST00000583521.1 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[highly expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 ENST00000583253.1 LncRNA Homo sapiens Myasthenia Gravis Expression(highly expressed) qRT-PCR//RNA-seq We identified 378 significantly upregulated and 348 significantly downregulated lncRNAs in MG patients compared with HC. The top 5 lncRNAs (NR_104677.1, ENST00000583253.1, NR_046098.1, NR_022008.1, and ENST00000581362.1) were validated and shown to be significantly increased in the serum exosome of MG, and the expression level of NR_046098.1 significantly increased with the MG grading. No 33543801 ENST00000577227 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ENST00000575404 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[highly expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 2. No 31619123 EPB41L4A-AS LncRNA Homo sapiens Uterine Cervical Neoplasms cervical carcinoma tissues Expression[lower expressed] qRT-PCR//Microarray CACX is one of the most common cancer affecting women world-wide. Here, expression microarray analysis revealed 8 over-expressed transcribed pseudogenes (GBP1P1, HLA-DRB6, HLA-H, SLC6A10P, NAPSB, KRT16P2, PTTG3P and RNF126P1), down-regulated 7 lincRNAs (H19, MIR100HG, MEG3, DIO3OS, HOXA11-AS, CD27-AS1 and EPB41L4A-AS) and 6 snoRNAs (SNORD97, SNORD3A, SNORD3C, SNORD3D, SNORA12 and SCARNA9) as DEncGs (log2 fold-change ≥ ±1.0) in CACX. No 31229557 EPB41L4A-DT LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ENST00000570186 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).27). No 33330027 EPEL LncRNA Homo sapiens Scleroderma, Systemic blood Expression[highly expressed] qRT-PCR Plasma levels of EPEL and p53 were significantly upregulated in ovarian endometrioid adenocarcinoma patients. No 31621389 EYA3 CircRNA Homo sapiens Stomach Neoplasms blood Expression[lower expressed] qRT-PCR//circRNA-seq The top 5 up- and downregulated circRNAs in patients with are listed in Table IV. No 32765789 EYA1-216 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 EXOG LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 EXOC7 LncRNA Homo sapiens Uterine Cervical Neoplasms serum Expression[highly expressed] qRT-PCR The expression of lncRNA-EXOC7 in serum and serum-derived exosomes in CC patients was markedly elevated compared with that in healthy controls. The AUCs of serum and exosomal lncRNA-EXOC7 in distinguishing CC patients from healthy controls were 0.9388 and 0.8982, respectively. The expression of lncRNA-EXOC7 in serum and exosomes was correlated with the FIGO stage of CC (p = 0.041 or 0.010), and positively correlated with levels of CYFRA211, TPS, and SCC (all with p < 0.05). No 32658426 EXOC3-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 EWSAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue and cell Interaction(miR-330-5p/ITGA5 Axis) Transwell Assay//qRT-PCR//Luciferase Report Assay//Western Blot In NSCLC tissue and cell, EWSAT1 was upregulated significantly, demonstrating a correlation with tumor diameter, differentiation, lymph node metastasis, and TNM stage.Dual luciferase reporter gene assay confirmed targeting relationships among miR-330-5p, EWSAT1, and ITGA5. In comparison with the Blank group, the number of cell clones in the shEWSAT1 group and siITGA5 decreased, with declined invasion and migration but increased apoptotic rate. In NSCLC tissue and cell, EWSAT1 was upregulated significantly, demonstrating a correlation with tumor diameter, differentiation, lymph node metastasis, and TNM stage. No 33928467 EVA1C LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 EVA1A-210 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ESS2 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction[HER2] Flow Cytometry//qRT-PCR//MTT In the current research, we found ES3 upregulation in breast cancer and its diagnostic value in breast cancer diagnosis. In addition, our data demonstrated that ES3 expression downregulated during neural differentiation. Therefore, its expression may be correlated to breast tumor differentiation status. Notably, a high expression level of ES3 in HER2-positive breast tumor tissues motivated us to investigate the effect of HER2 on ES3 expression by blocking HER2 activity with lapatinib. The results showed that ES3 expression suppressed when HER2 activity was blocked. In summary, for the first time, we found that lncRNA ES3 was significantly upregulated in HER2-positive breast tumors and may contribute to breast cancer proliferation as a downstream target of HER2. Furthermore, our findings revealed that ES3 transcript has a high expression in high-grade and high-stage breast tumors. No 31211468 ESRG LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ESRG LncRNA Homo sapiens Colorectal Neoplasms colorectal tumors Expression [highly expressed] Bioinformatics Analysis Our results nominated ESRG, LINC00518, PWRN1, and TTTY14 lncRNAs as the top-hit novel lncRNAs with aberrant expression in colon cancer. The qPCR method was used to profile these lncRNAs that showed the up-regulation of ESRG and LINC00518, and down-regulation of TTTY14 in thirty paired colorectal cancer specimens. No 34896077 ESR1 LncRNA Homo sapiens Coronary Disease 506 patients and 506 healthy subjects Interaction(rs6927072, rs4870061 ) Genotyping Our study showed that GAS5 rs17359906 (OR 2.32, p = 0.020) and rs75315904 (OR 0.41, p = 0.039) were related to the risk of CHD in females. ESR1 rs6927072 (OR 1.76, p = 0.007) and rs4870061 (OR 0.74, p = 0.036) correlated with CHD risk in age ≤ 60 years. GAS5 rs17359906 (OR 0.10, p = 0.032) and ESR1 rs3020308 (OR 2.73, p = 0.041) were associated with an increased susceptibility to CHD in smokers. We also found that METTL14 rs4834698 (OR 1.57, p = 0.044) and ESR1 rs4870061 (OR 0.62, p = 0.040) were associated with CHD susceptibility in non-drinkers. Besides, METTL14 rs17050450 (OR 0.48, p = 0.029) and ESR1 rs3853248 (OR 1.61, p = 0.018) had the susceptibility of CHD patients with diabetes. Our study indicated that GAS5/METTL14/ESR1 polymorphisms were associated with CHD risk, which might provide a new understanding of CHD in a Chinese population. No 35235104 ESPL1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)42) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 ERVH48-1 LncRNA Homo sapiens Urinary Bladder Neoplasms cell lines Expression[highly expressed] qRT-PCR As shown in Figure 8A and ​andB,B, the expression of 4 lncRNAs (MIR137HG, LINC00525, ERVH48-1 and LINC00518) was upregulated, while the expression of AC110491.1 and ADAMTS9-AS1 was downregulated in MIBC tissues and bladder cancer cells (T24, J82, UM-UC-3, TCCSUP and SW780) compared with the expression in adjacent nontumor bladder tissues and the immortalized SV-HUC-1 uroepithelial cells, respectively. No 31308745 ERRLR01 LncRNA Homo sapiens Breast Neoplasms triple-negative breast cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq " Specifically, ERRLR01 levels were elevated in triple-negative breast cancer (TNBC) as compared with Luminal-A, Luminal-B, and HER2 breast cancer subtypes. Upon stratification, OS in ERα- tumors correlated with negative overall survival, while in ERα+ tumors, ERRLR01 correlated with positive outcomes. This suggests ERRLR01 is modulated by hormone signaling in breast cancer. Gene-network analysis revealed ERRLR01 correlated with distinct pathways including ""epithelial development"" and ""cellular differentiation.""" ERRLR01 levels were also inversely correlated with breast cancer survival across all breast cancer patients. No 28795861 ERLNC1 LncRNA Homo sapiens Stomach Neoplasms GC specimens Expression(highly expressed) qRT-PCR We found that TC0101441 expression was significantly increased in GC specimens compared to that in the normal specimens (P < 0.01). High TC0101441 expression was correlated with lymphatic metastasis (P = 0.027) and TNM stage (P = 0.015). TC0101441 could distinguish GC specimens from adjacent normal gastric specimens with an area under the receiver operating characteristic curve (AUC) of 0.8082. No 33786153 ERLNC1 LncRNA Homo sapiens Endometriosis ectopic endometria Expression[highly expressed] qRT-PCR Clinically, we found that TC0101441 was highly expressed in ectopic endometria than in the eutopic and normal endometria. No 31911152 ERGIC3-209 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 ERG-214 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ERCC6L2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 EPS15-209 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 EPN2-IT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 EPN2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 EPIC1 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 EPHB6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 EPHA1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 EPGN LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 EPGN LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 ENST00000573301 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ENST00000569808.1 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[highly expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 ENSG00000254548.1 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 ENST00000416100.1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma plasma exosome Expression[highly expressed] qRT-PCR//RNA-seq Expression levels of the lncRNAs NR_039819, NR_036133, NR_003353, ENST00000442416.1, and ENST00000416100.5 were significantly higher in exosomes from ESCC patients than non-cancer controls. No 32597791 ENST00000411554 LncRNA Homo sapiens Diabetic Foot skin tissues Regulation[lncRNA‑ENST00000411554/MAPK1 axis] Microarray//FISH//qRT-PCR//Western Blot A target regulatory association was identified between downregulated lncRNA‑ENST00000411554 and upregulated mitogen‑activated protein kinase (MAPK)1 in DFU tissues, and a negative correlation was detected between this RNA and protein.The present results suggested that an immune functional disorder of T lymphocytes may be closely associated with the development of DFUs. Furthermore, activation of the MAPK signal transduction pathway mediated by the lncRNA‑ENST00000411554/MAPK1 axis may affect the DFU immune regulatory imbalance. No 30664216 ENST00000392385 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 ENST00000381108.3 LncRNA Homo sapiens Diabetes Mellitus, Type 2 five patients with T2D and paired controls Expression(highly expressed) qRT-PCR//Bioinformatics Analysis//Microarray The top five upregulated lncRNAs are ENST00000381108.3, ENST00000515544.1, ENST00000539543.1, ENST00000508174.1, and ENST00000564527.1, and the top five downregulated lncRNAs are TCONS_00017539, ENST00000430816.1, ENST00000533203.1, ENST00000609522.1, and ENST00000417079.1. No 35257412 ENST00000378432 LncRNA Homo sapiens Henoch-Schönlein Purpura Nephritis blood Expression[lower expressed] qRT-PCR//RNA-seq The results revealed that the expression of lncRNAs including ENST00000378432, ENST00000571370, uc001kfc.1 and uc010qna.2 was decreased in HSPN patients compared with that in healthy controls. No 30651843 ENSRNOT00000085586 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[highly expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 ENSRNOT00000083823.1 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[lower expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 ENSRNOT00000078751 LncRNA Homo sapiens Diabetic Macroangiopathy thoracic aorta tissue Expression[lower expressed] Tunel//qRT-PCR//RNA-seq//H&E Staining//ELISA The detailed information of the top 10 upregulated and 10 downregulated lncRNAs and mRNA summarized in Tables ?Tables77 and ?and8.8. These results reflect distinct lncRNAs and mRNA expression profiles between the test group and the control group, implying different underlying pathophysiology in diabetic macroangiopathy. No 33378343 ENSRNOT00000065561 LncRNA Rattus norvegicus Chronic Intermittent Hypoxia heart tissues Expression[highly expressed] qRT-PCR "To validate the reliability of our microarray results, three upregulated lncRNAs (XR_596701, XR_344474, and ENSRNOT00000065561) and three downregulated lncRNAs (XR_600374, XR_590196, and XR_597099) were randomly selected to perform qRT-PCR verification in same RNA samples used for the microarray analyses. To our interesting, the qRT-PCR results were in agreement with the microarray findings, which demonstrated the same trends of up- or downregulation for each differentially expressed lncRNA (Fig. 6). " No 30535531 ENSRNOT00000054583.1 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[highly expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 ENSRNOT00000054495.1 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[highly expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 ENSRNOT00000048692 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[highly expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 ENSRNOT00000014917 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[lower expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 ENSRNOT00000001712 LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[highly expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 ENSG00000277999.1 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[highly expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 ENSG00000276649.1 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[lower expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 ENSG00000273576.1 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 ENSG00000272046 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 ENSG00000271862 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 ENSG00000269936 LncRNA Homo sapiens Dissection, Thoracic Aorta Human TAD (n=3) and normal aortic tissues (NA) (n=3) Expression [highly expressed] qRT-PCR//RNA-seq//Bioinformatics Analysis QRT-PCR results of five dysregulated genes were consistent with HTS data. A lncRNA-mRNA coexpression analysis showed positive correlations between the up-regulated lncRNA (ENSG00000269936) and its adjacent up-regulated mRNA (MAP2K6, R=0.940, P< 0.01), and between the down-regulated lncRNA_1421 and its down-regulated mRNAs (FBLN5, R=0.950, P< 0.01; ACTA2, R=0.96, P< 0.01; TIMP3, R=0.96, P< 0.05). The lncRNA-miRNA-mRNA network indicated that the up-regulated lncRNA XIST and p21 had similar sequences targeted by has-miR-17-5p. The results of luciferase assay and fluorescence immuno-cytochemistry were consistent with that. And qRT-PCR results showed that lncRNA XIST and p21 were expressed at a higher level and has-miR-17-5p was expressed at a lower level in TAD than in NA. The predicted binding motifs of three up-regulated lncRNAs (ENSG00000248508, ENSG00000226530, and EG00000259719) were correlated with up-regulated RUNX1 (R=0.982, P< 0.001; R=0.967, P< 0.01; R=0.960, P< 0.01, respectively). No 29669321 ENSG00000269900 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 ENSG00000267458.1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] Microarray Moreover, the intersection analysis between 130 gene symbols and 73 gene symbols showed a total of nine miRNAs, and the number of targeted lncRNA was 11, which served as the differentially expressed lncRNA (Table 1). No 35117179 ENSG00000262979.1 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[highly expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 ENSG00000260114.2 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[highly expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 ENSG00000258908.1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] Microarray Moreover, the intersection analysis between 130 gene symbols and 73 gene symbols showed a total of nine miRNAs, and the number of targeted lncRNA was 11, which served as the differentially expressed lncRNA (Table 1). No 35117179 ENSG00000258444.1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] Microarray Moreover, the intersection analysis between 130 gene symbols and 73 gene symbols showed a total of nine miRNAs, and the number of targeted lncRNA was 11, which served as the differentially expressed lncRNA (Table 1). No 35117179 ENSG00000257922.1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] Microarray Moreover, the intersection analysis between 130 gene symbols and 73 gene symbols showed a total of nine miRNAs, and the number of targeted lncRNA was 11, which served as the differentially expressed lncRNA (Table 1). No 35117179 ENSG00000257514.1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] Microarray Moreover, the intersection analysis between 130 gene symbols and 73 gene symbols showed a total of nine miRNAs, and the number of targeted lncRNA was 11, which served as the differentially expressed lncRNA (Table 1). No 35117179 ENSG00000255864.5 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[lower expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 ENSG00000255026.1 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[lower expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 ENST00000412204.1 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[lower expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 ENST00000416361 LncRNA Homo sapiens Coronary Artery Disease plasma Expression[highly expressed] qRT-PCR Reverse transcription?quantitative (RT?q)PCR data revealed that the expression level of the novel lncRNA ENST00000416361 was ~2.3?fold higher in the plasma of 50 patients with CAD compared with the 50 control subjects. No 32323776 ENST00000568884 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ENST00000419863 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ENST00000568585 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).36). No 33330027 ENST00000566945 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).18). No 33330027 ENST00000564527.1 LncRNA Homo sapiens Diabetes Mellitus, Type 2 five patients with T2D and paired controls Expression(highly expressed) qRT-PCR//Bioinformatics Analysis//Microarray The top five upregulated lncRNAs are ENST00000381108.3, ENST00000515544.1, ENST00000539543.1, ENST00000508174.1, and ENST00000564527.1, and the top five downregulated lncRNAs are TCONS_00017539, ENST00000430816.1, ENST00000533203.1, ENST00000609522.1, and ENST00000417079.1. No 35257412 ENST00000560199 LncRNA Homo sapiens Arthritis, Rheumatoid peripheral blood mononuclear cells Expression[lower expressed] qRT-PCR The expression levels of NR_002819, NR_038935, and ENST00000603415 were significantly increased in the RA-ILD group, while the expression level of ENST00000560199 was significantly decreased. No 32133566 ENST00000551672.1 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[lower expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 ENST00000539543.1 LncRNA Homo sapiens Diabetes Mellitus, Type 2 five patients with T2D and paired controls Expression(highly expressed) qRT-PCR//Bioinformatics Analysis//Microarray The top five upregulated lncRNAs are ENST00000381108.3, ENST00000515544.1, ENST00000539543.1, ENST00000508174.1, and ENST00000564527.1, and the top five downregulated lncRNAs are TCONS_00017539, ENST00000430816.1, ENST00000533203.1, ENST00000609522.1, and ENST00000417079.1. No 35257412 ENST00000533203.1 LncRNA Homo sapiens Diabetes Mellitus, Type 2 five patients with T2D and paired controls (lower expressed) qRT-PCR//Bioinformatics Analysis//Microarray The top five upregulated lncRNAs are ENST00000381108.3, ENST00000515544.1, ENST00000539543.1, ENST00000508174.1, and ENST00000564527.1, and the top five downregulated lncRNAs are TCONS_00017539, ENST00000430816.1, ENST00000533203.1, ENST00000609522.1, and ENST00000417079.1. No 35257412 ENST00000527021 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[highly expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 5. No 31619123 ENST00000523317 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ENST00000520185 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 ENST00000514544 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).11). No 33330027 ENST00000500843 LncRNA Homo sapiens Adenocarcinoma of Lung Cell lines（A549 ） Expression[lower expressed] qRT-PCR//Cell Apoptosis Assay In previous studies, lncRNA ENST00000500843 was identified to be downregulated in PTX-resistant A549 human lung cancer cells. No 31516584 ENST00000500180 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[lower expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 ENST00000479395 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ENST00000470758 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[lower expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).38). No 33330027 ENST00000450247 LncRNA Homo sapiens Carcinoma, Renal Cell blood Expression[highly expressed] qRT-PCR//Microarray We preferentially selected the top 20 up-regulated and top 20 down-regulated lncRNAs and mRNAs (Tables 2, ?,3).16). No 33330027 ENST00000448134 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[highly expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 ENST00000444770 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[highly expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 9. No 31619123 ENST00000440688.1 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR//Microarray After a multi-stage validation, we finally revealed three lncRNAs, ENSG00000248932.1, ENST00000440688.1 and ENST00000457302.2, increased in HCC comparing with the both chronic hepatitis (CH) patients and cancer-free controls. No 31811749 ENST00000439796 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[highly expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 ENST00000437825.1 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[lower expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 ENST00000436484.1 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[highly expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 ENST00000435049 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[lower expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 ENST00000433410 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 ENST00000433249 LncRNA Homo sapiens Brain Injuries, Traumatic Brain tissues Expression[lower expressed] qRT-PCR//Microarray LncRNA and mRNA expression profiles were detected in three TBI and three control groups. Volcano plot filtering identified 99 differentially expressed lncRNAs (P < 0.05, fold change > 1.2) (Figure ​1A1A and ​andB).B). Among them, 43 lncRNAs were up-regulated and 56 lncRNAs were down-regulated. In the TBI group, n333955, n332943, n335470, ENST00000384390, and n341115 were the five most significantly up-regulated lncRNAs. While, TCONS_00018733-XLOC_008489, OTTHUMT00000076953, NR_029967, ENST00000433249, and n381234 were the five most significantly down-regulated lncRNAs (Table 3). Next, we compared mRNA expression profiles of the TBI group with the control group. No 30632503 ENST00000430816.1 LncRNA Homo sapiens Diabetes Mellitus, Type 2 five patients with T2D and paired controls (lower expressed) qRT-PCR//Bioinformatics Analysis//Microarray The top five upregulated lncRNAs are ENST00000381108.3, ENST00000515544.1, ENST00000539543.1, ENST00000508174.1, and ENST00000564527.1, and the top five downregulated lncRNAs are TCONS_00017539, ENST00000430816.1, ENST00000533203.1, ENST00000609522.1, and ENST00000417079.1. No 35257412 ENST00000428786 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[highly expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 6. No 31619123 ENST00000427261 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[lower expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 ENST00000422194 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 DIRC3-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 DIRC3 LncRNA Homo sapiens Stomach Neoplasms tissues Regulation qRT-PCR//RNA-seq The results of our study demonstrated that the five-lncRNAs PART1, UCA1, DIRC3, HOTAIR, and HOXA11AS require more investigation to be confirmed as diagnostic biomarkers in gastric cancer. No 35949302 DIRC3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 823 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 CIZ1-210 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[lower expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 CIT-208 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ciRS-7 CircRNA Homo sapiens Esophageal Squamous Cell Carcinoma Regulation[EGFR signaling] Western Blot//RIP//PCR//IP//IF In our recent study, we have found that the expression of ciRS-7 is abnormally increased in the esophageal squamous cell carcinoma (ESCC), and may function as an oncogene to accelerate ESCC progression through sponging miR-876-5p.Mechanically, miR-1299 could directly bind to the 3'-untranslated region of epidermal growth factor receptor (EGFR) and then affects its downstream Akt-mTOR pathway in ESCC cells. Consistent with our past findings, ciRS-7 could also sponge miR-1299 in ESCC cells. Taken together, this study has shed light on that circular RNA ciRS-7 inhibits autophagy of ESCC cells by functioning as miR-1299 sponge to target EGFR signaling. No 31490018 cirMLLT10 CircRNA Homo sapiens Stomach Neoplasms GC patients Regulation qRT-PCR//Bioinformatics Analysis//Microarray Nine miRNAs and eight lncRNAs were obtained from the microarray analysis. Six miRNAs (miR-550a-5p, miRNA-936, miR-1306-3p, miR-3185, miR-6083, miR-6792-3p) and three lncRNAs (lnc-MB21D1-3:5, lnc-PSCA-4:2 and lnc-ABCC5-2:1) were abnormally expressed in circulating and tissue samples compared with normal control (NC), which was closely related to clinical pathology and survival time of GC patients; circRNA sequencing and qRT-PCR revealed four circRNAs (circASHL2, circCCDC9, circNHSL1 and cirMLLT10) were abnormally expressed in GC tissues and parts of them were negative relationship with their predicted binding miRNAs. No 34295803 cir_ITCH CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR Our results showed that the expression of cir_ITCH and circHIPK3 were significantly downregulated in GC tumoral tissues compared with their paired adjacent nonneoplastic counterparts. No 30866608 cicBIRC6 CircRNA Homo sapiens Breast Neoplasms metastatic tumor cells Expression(highly expressed) qPCR//PCR Surprisingly expression of cicBIRC6 was significantly upregulated in these metastatic tumor cells. In comparison with 4T1T, cicBIRC6 was upregulated 5.7 and 3.5 times in 4T1B and 4T1L respectively. No 36456770 CIBAR1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CIB2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CHSY3-202 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 chrx_20167747_20162964_-4783 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 383 were up-regulated and down-regulated, respectively. No 31843366 chrx_16702941_16693141_-9800 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 390 were up-regulated and down-regulated, respectively. No 31843366 chrx_150816078_150793691_-22387 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 369 were up-regulated and down-regulated, respectively. No 31843366 chrx_136747592_136732102_-15490 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 276 were up-regulated and down-regulated, respectively. No 31843366 chrx_118776511_118741017_-35494 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 292 were up-regulated and down-regulated, respectively. No 31843366 CHRM3-AS2 LncRNA Homo sapiens Neuroblastoma Neuroblastoma tissues Expression[lower expressed] ChIP-seq//RNA-seq Differential analysis revealed nine significantly differentially expressed (more than 2-fold change with corrected p-value) lncRNAs between tumor cells and matched MNCs. Of these, RFPL1S (p = 0.0001), PPP1R26-AS1 (p = 0.03), RP11-439E19.3 (p = 1.24 × 10–6), CASC15 (p = 1.6 × 10–7), AC004540.5 (p = 0.0002), and CTD-2881E23.2 (p = 1.6 × 10–9) were found to be significantly Expression[up-expression]regulated (Figure 1B), while USP3-AS1 (p = 1.78 × 10–6), CHRM3-AS2 (p = 0.003) and RP6-99M1.2 (p = 0.002) were significantly downregulated (Figure 1C). No 31920530 CHRF LncRNA Mus musculus Cardiomegaly cellular models of cardiac hypertrophy Regulation[miR-93/Akt3 axis] qRT-PCR//Luciferase Report Assay//RIP//Western Blot CHRF expression was up-regulated and miR-93 expression was down-regulated in mice and cellular models of cardiac hypertrophy. CHRF induced cardiac hypertrophy by regulating miR-93/Akt3 axis in Iso-stimulated cardiomyocytes, deepening our understanding of the molecular mechanisms of lncRNAs in cardiac hypertrophy and providing a potential therapy target for cardiac hypertrophy. No 29747050 CHRAC1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 chr9_97371706_97369922_-1784 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 257 were up-regulated and down-regulated, respectively. No 31843366 chr9_96484633_96458379_-26254 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 478 were up-regulated and down-regulated, respectively. No 31843366 chr9_85712566_85618983_-93583 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 304 were up-regulated and down-regulated, respectively. No 31843366 chr9_85646435_85575315_-71120 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 468 were up-regulated and down-regulated, respectively. No 31843366 chr9_85633374_85618983_-14391 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 360 were up-regulated and down-regulated, respectively. No 31843366 chr9_81620557_81610220_-10337 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 448 were up-regulated and down-regulated, respectively. No 31843366 chr9_76096102_76067955_-28147 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 380 were up-regulated and down-regulated, respectively. No 31843366 chr9_4827033_4823548_-3485 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 335 were up-regulated and down-regulated, respectively. No 31843366 chr9_35706111_35705750_-361 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 357 were up-regulated and down-regulated, respectively. No 31843366 chr9_35243365_35228013_-15352 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 513 were up-regulated and down-regulated, respectively. No 31843366 chr9_135883078_135866456_-16622 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 305 were up-regulated and down-regulated, respectively. No 31843366 chr9_109943381_109942686_-695 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 325 were up-regulated and down-regulated, respectively. No 31843366 chr9_109064567_109033307_-31260 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 250 were up-regulated and down-regulated, respectively. No 31843366 CITF22-49E9.3 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 CKAP2L LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 chr8_91318380_91289136_-29244 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 307 were up-regulated and down-regulated, respectively. No 31843366 cKifap3 LncRNA Homo sapiens Corneal Neovascularization corneas Expression[lower expressed] qPCR//Transwell Assay//Microarray qPCR detection showed that the ortholog of cZFP609 was significantly increased in the vascularized human corneas (Figs. 3A, B). By contrast, the ortholog of cKifap3 was significantly decreased in the vascularized human corneas No 31436645 CPC5-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung TCGA(LUAD cancer and normal samples) Regulation Survival Analysis Herein, we identified an eight-lncRNA signature (PR-lncRNA signature, NPSR1-AS1, SATB2-AS1, LINC01090, FGF12-AS2, AC005256.1, MAFA-AS1, BFSP2-AS1, and CPC5-AS1), which contributes to predicting LUAD patient's prognosis risk and survival outcomes. Of them, NPSR1-AS1, SATB2-AS1, FGF12-AS2, and AC005256.1 could be acted as the poor prognosis markers, while LINC01090, MAFA-AS1, BFSP2-AS1, and CPC5-AS1 were treated as the protective factors for survival in LUAD patients. No 34550610 CP LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 COX15 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 COTL1-202 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 CORO1C CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 COPS3-209 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 COPS3-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 COPG2IT1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 COPB2-DT LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR//Microarray After a multi-stage validation, we finally revealed three lncRNAs, ENSG00000248932.1, ENST00000440688.1 and ENST00000457302.2, increased in HCC comparing with the both chronic hepatitis (CH) patients and cancer-free controls. No 31811749 COPB2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 COMETT LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR Here, we found that the levels of LINC01510 in CRC tissues were significantly higher than those in matched tumor-adjacent tissues. Moreover, high LINC01510 expression was observed to be closely correlated with histology/differentiation (p = 0.001), depth of invasion (p = 0.004) and TNM stage (p = 0.003). From the Kaplan-Meier survival curves, it was observed that patients with high expression of LINC01510 had shorter overall survival (p = 0.004) and disease-free survival (p = 0.000) as compared with the LINC01510-low group. No 30536314 COL11A1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 COG7 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 COBLL1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 CNTNAP3P2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CNTNAP3P2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 CNTLN CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 CNPY3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CNOT9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CNKSR2-239 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CNKSR2-231 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CNIH2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 cMTO1 CircRNA Homo sapiens Liver Cirrhosis cirrhotic liver tissues regulation[ miR-181b-5p-mediated PTEN expression] qPCR//PCR//IF cMTO1 was shown to be reduced in the liver from patients with cirrhosis. In addition, cMTO1 was down-regulated in the mouse fibrotic livers as well as activated hepatic stellate cells (HSCs). cMTO1 inhibits HSC activation, at least in part, through miR-181b-5p-mediated PTEN expression. No 32850833 CLPX LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CLLU1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CLIP1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CLIC5 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[lower expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 CLCN1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CLCA4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 chr8_92076137_91986124_-90013 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 352 were up-regulated and down-regulated, respectively. No 31843366 chr8_51861246_51859279_-1967 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 336 were up-regulated and down-regulated, respectively. No 31843366 CPNE8-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Regulation(cpne8) Western Blot//ISH//Transfection//Wound Healing Assay//qRT-PCR//Cell Apoptosis Assay//Bioinformatics Analysis//Transwell Assay Among the differentially expressed lncRNAs, RP11-396F22.1 expression was one of the most significantly overexpressed in the CC tissues compared to nomal cervical tissues (P<0.001). In situ hybridization confirmed RP11-396F22.1 expression was highly expressed in cancerous tissues. The results of Scratch and Transwell test showed that the migration ability decreased remarkably in transfected group (P<0.001). Moreover, the coding gene cpne8 was significantly upregulated by RP11-396F22.1 knockdown (P=0.035). No 29636859 chr6_118523920_118511298_-12622 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 388 were up-regulated and down-regulated, respectively. No 31843366 chr6_109743772_109715078_-28694 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 365 were up-regulated and down-regulated, respectively. No 31843366 chr6_107924932_107911346_-13586 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 291 were up-regulated and down-regulated, respectively. No 31843366 chr5_77353406_77325539_-27867 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 415 were up-regulated and down-regulated, respectively. No 31843366 chr5_56865977_56856600_-9377 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 503 were up-regulated and down-regulated, respectively. No 31843366 chr5_53658626_53646232_-12394 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 285 were up-regulated and down-regulated, respectively. No 31843366 chr5_50763243_50750148_-13095 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 489 were up-regulated and down-regulated, respectively. No 31843366 chr5_40950014_40945198_-4816 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 361 were up-regulated and down-regulated, respectively. No 31843366 chr5_36986301_36982165_-4136 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 440 were up-regulated and down-regulated, respectively. No 31843366 chr5_33456227_33453289_-2938 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 362 were up-regulated and down-regulated, respectively. No 31843366 chr5_32739030_32724698_-14332 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 303 were up-regulated and down-regulated, respectively. No 31843366 chr5_176951577_176943335_-8242 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 384 were up-regulated and down-regulated, respectively. No 31843366 chr5_170610175-170632616+ CircRNA Homo sapiens Ovarian Neoplasms Serum Expression [differentially expressed] qRT-PCR//circRNA-seq//RNA-seq These 5 circRNAs exhibited increased differential expression in OC compared with normal samples. No 31589961 chr5_168492847_168488602_-4245 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 333 were up-regulated and down-regulated, respectively. No 31843366 chr5_139127853_139121035_-6818 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 446 were up-regulated and down-regulated, respectively. No 31843366 chr5_134697246_134692602_-4644 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 413 were up-regulated and down-regulated, respectively. No 31843366 chr5_113001674_113001084_-590 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 371 were up-regulated and down-regulated, respectively. No 31843366 chr5_103019843_102974116_-45727 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 249 were up-regulated and down-regulated, respectively. No 31843366 chr4_94586444_94523724_-62720 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 275 were up-regulated and down-regulated, respectively. No 31843366 chr4_77030970_76996425_-34545 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 400 were up-regulated and down-regulated, respectively. No 31843366 chr4_75790797_75774676_-16121 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 296 were up-regulated and down-regulated, respectively. No 31843366 chr4_64309931_64289710_-20221 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 374 were up-regulated and down-regulated, respectively. No 31843366 chr4_55489465_55475963_-13502 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 344 were up-regulated and down-regulated, respectively. No 31843366 chr4_53444105_53425871_-18234 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 499 were up-regulated and down-regulated, respectively. No 31843366 chr4_53444103_53399730_-44373 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 434 were up-regulated and down-regulated, respectively. No 31843366 chr4_48527653_48510059_-17594 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 498 were up-regulated and down-regulated, respectively. No 31843366 chr4_47786925_47763379_-23546 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 329 were up-regulated and down-regulated, respectively. No 31843366 chr4_47678054_47641915_-36139 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 279 were up-regulated and down-regulated, respectively. No 31843366 chr4_42465076_42464690_-386 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 378 were up-regulated and down-regulated, respectively. No 31843366 chr4_39321374_39304814_-16560 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 462 were up-regulated and down-regulated, respectively. No 31843366 chr6_110322872_110298922_-23950 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 456 were up-regulated and down-regulated, respectively. No 31843366 chr6_135323324_135300500_-22824 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 331 were up-regulated and down-regulated, respectively. No 31843366 chr8_51654760_51499699_-155061 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 267 were up-regulated and down-regulated, respectively. No 31843366 chr6_149676737_149676260_-477 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 354 were up-regulated and down-regulated, respectively. No 31843366 chr8_51345947_51320784_-25163 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 471 were up-regulated and down-regulated, respectively. No 31843366 chr8_39165196_39136657_-28539 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 424 were up-regulated and down-regulated, respectively. No 31843366 chr8_38260147_38240275_-19872 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 273 were up-regulated and down-regulated, respectively. No 31843366 chr8_38128951_38114192_-14759 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 484 were up-regulated and down-regulated, respectively. No 31843366 chr8_37877551_37870420_-7131 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 289 were up-regulated and down-regulated, respectively. No 31843366 chr8_26583983_26581969_-2014 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 280 were up-regulated and down-regulated, respectively. No 31843366 chr8_141221765_141215759_-6006 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 461 were up-regulated and down-regulated, respectively. No 31843366 chr8_140890769_140830472_-60297 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 464 were up-regulated and down-regulated, respectively. No 31843366 chr7_91118208_91112542_-5666 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 435 were up-regulated and down-regulated, respectively. No 31843366 chr7_81982627_81959275_-23352 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 454 were up-regulated and down-regulated, respectively. No 31843366 chr7_5217187_5216563_-624 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 330 were up-regulated and down-regulated, respectively. No 31843366 chr7_44675268_44674411_-857 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 398 were up-regulated and down-regulated, respectively. No 31843366 chr7_40088331_40062826_-25505 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 411 were up-regulated and down-regulated, respectively. No 31843366 chr7_158918869_158879684_-39185 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 405 were up-regulated and down-regulated, respectively. No 31843366 chr7_13911307_13900738_-10569 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 394 were up-regulated and down-regulated, respectively. No 31843366 chr7_101224141_101223477_-664 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 310 were up-regulated and down-regulated, respectively. No 31843366 chr6_75678927_75675435_-3492 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 507 were up-regulated and down-regulated, respectively. No 31843366 chr6_75678927_75666712_-12215 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 493 were up-regulated and down-regulated, respectively. No 31843366 chr6_73736508_73723251_-13257 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 259 were up-regulated and down-regulated, respectively. No 31843366 chr6_32581838_32521905_-59933 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 313 were up-regulated and down-regulated, respectively. No 31843366 chr6_32581836_32521903_-59933 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 237 were up-regulated and down-regulated, respectively. No 31843366 chr6_30731100_30730022_-1078 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 426 were up-regulated and down-regulated, respectively. No 31843366 chr6_25554096_25509656_-44440 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 351 were up-regulated and down-regulated, respectively. No 31843366 chr6_17856122_17836878_-19244 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 318 were up-regulated and down-regulated, respectively. No 31843366 chr6_17675770_17665239_-10531 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 381 were up-regulated and down-regulated, respectively. No 31843366 chr6_170395579_170358226_-37353 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 376 were up-regulated and down-regulated, respectively. No 31843366 chr6_167889326_167870383_-18943 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 477 were up-regulated and down-regulated, respectively. No 31843366 chr6_162443473_162262525_-180948 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 261 were up-regulated and down-regulated, respectively. No 31843366 chr6_149680457_149676260_-4197 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 476 were up-regulated and down-regulated, respectively. No 31843366 CPEB2-DT LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression(lower expressed) qRT-PCR DRAIR expression was downregulated in GC tissues than in non-tumor tissues and in plasma of GC patients than in plasma of healthy controls. . DRAIR expression in tumor tissues was closely and positively correlated with its expression in plasma. Plasma DRAIR effectively separated GC patients from controls. High DRAIR levels in tumor tissues and plasma samples were closely correlated with poor survival of GC patients. No 34510245 CR608741 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[highly expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 DIRC3 LncRNA Homo sapiens Melanoma Interaction[MITF-SOX10] qRT-PCR//Colony Formation Assay//Western Blot Our work suggests that one of these, Disrupted In Renal Carcinoma 3 (DIRC3), may be a clinically important MITF-SOX10 regulated tumour suppressor. DIRC3 depletion in human melanoma cells leads to increased anchorage-independent growth, a hallmark of malignant transformation, whilst melanoma patients classified by low DIRC3 expression have decreased survival. DIRC3 is a nuclear lncRNA that activates expression of its neighbouring IGFBP5 tumour suppressor through modulating chromatin structure and suppressing SOX10 binding to putative regulatory elements within the DIRC3 locus. In turn, DIRC3 dependent regulation of IGFBP5 impacts the expression of genes involved in cancer associated processes and is needed for DIRC3 control of anchorage-independent growth. Our work indicates that lncRNA components of MITF-SOX10 networks are an important new class of melanoma regulators and candidate therapeutic targets that can act not only as downstream mediators of MITF-SOX10 function but as feedback regulators of MITF-SOX10 activity. No 31881017 DBF4B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DANCR LncRNA Homo sapiens Breast Neoplasms serum exosomal Expression(highly expressed) qRT-PCR Serum exosomal lncRNA DANCR levels were significantly higher in BC patients than in BBD patients and normal controls. High serum exosomal lncRNA DANCR level was associated with various clinicopathological variables including lymph node metastasis, ER status, HER2 status, and TNM stage.In addition, the BC patients in the high serum exosomal lncRNA DANCR expression group had significantly shorter 5-year overall survival time. No 35150011 DANCR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DANCR LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Interaction[binding to lysine acetyltransferase 6A] qRT-PCR//RIP//Western Blot In this study, we identified the lncRNA, DANCR, which was Expression[up-expression]regulated in colorectal cancer. We further demonstrated that DANCR bound with lysine acetyltransferase 6A. This binding was essential for KAT6A acetyltransferase activity and thus, it influenced the expression of KAT6A target genes. The Expression[up-expression]regulation of DANCR expression was associated with shorter patient survival time No 31863900 DANCR LncRNA Homo sapiens Colorectal Neoplasms CRC tissue and serum Expression[highly expressed] qRT-PCR It was found that DANCR level in the CRC tissue and serum was significantly increased, and serum DANCR expression was decreased in post-operative patients as compared with that in pre-treatment patients and recurrent patients. No 32159208 DANCR LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer cell lines HCT116, RKO, SW620, HT-29 Interaction(MALAT1 ) Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Cell Cycle Assay//IF In a high throughput screening for lncRNAs involved in Doxorubicin-induced apoptosis, we found DANCR was suppressed by Doxorubicin and it acted as an important repressor of apoptosis in colorectal cancer. Further studies demonstrated that DANCR promoted the oncogenic lncRNA MALAT1 expression via enhancing the RNA stability of MALAT1 to suppress apoptosis. No 33414433 DANCR LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Interaction(miR-145-5p/NRAS) qRT-PCR//Bioinformatics Analysis Our results revealed that the expression level of DANCR was significantly upregulated in colorectal cancer tissues (p < 0.001). It was demonstrated that DANCR could regulate NRAS expression by sponging miR-145-5 in colorectal cancer patients. No 33956301 DANCR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR The expression level of lncRNA NEAT1, H19, MALAT1, HOTAIR, DANCR, UCA1, and BCAR4 were significantly decreased, compared with that in adjacent noncancerous tissues (all P <.05). The expression level of lncRNA GAS5 was statistically significantly increased (P <.05). For the quantitative polymerase chain reaction (qPCR) assay, 8 kinds of lncRNAs were detected as a result of the GeXP assay. No 30423146 DANCR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR We found that DANCR was significantly overexpressed in HCC tissues and associated with prognosis of HCC patients. No 32103983 DANCR LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Expression(highly expressed) qRT-PCR ANCR expression was increased in NPC tissues compared to non-cancerous nasopharyngeal mucosae. ANCR expression was significantly related to lymph node metastasis, clinical stage, and tumor differentiation (P < .05). Kaplan-Meier survival analysis revealed that high level of ANCR expression was significantly associated with poor disease-free survival but not with OS in NPC patients. No 34414934 DANCR LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Expression[lower expressed] qRT-PCR These results demonstrated that the expression of DANCR was notably decreased in tumor tissues in comparison with adjacent normal tissues (P<0.001). Furthermore, the present study found that DANCR expression level was correlated to T grade (P<0.01) and TNM stage (P=0.017). No 30910839 DANCR LncRNA Homo sapiens Pancreatic Neoplasms regulation[MLL3 ] ISH//qRT-PCR//IHC//Western Blot The expression of DANCR showed gradual upregulated expression as pancreatic cancer progressed. The results show that MLL3 was overexpressed in the initial pancreatic cancer to restrict cancer progression and in which DANCR had no role in regulating MLL3 but in advanced stages it downregulated MLL3. No 33099938 DANCR LncRNA Homo sapiens Triple Negative Breast Neoplasms breast tissues regulation[miR-874-3p-SOX2 axis] Western Blot//ISH//qRT-PCR//Luciferase Report Assay//ELISA//Transwell Assay The levels of DANCR in BC tissues and adjacent benign breast tissues were tested by qRT-PCR to explore the role of DANCR in TNBC. The upregulation of DANCR may contribute to the progression and tumor invasiveness of TNBC, considering that DANCR functions as a miR-874-3p sponge, thus modulating SOX2 positively. No 33058834 DANCR LncRNA Homo sapiens Osteoporosis Human BMSCs regulation[Wnt/β-catenin signaling pathway] qRT-PCR//Luciferase Report Assay//Western Blot The expression levels of DANCR and miR-320a in BMSCs derived from osteoporosis patients were upregulated, whereas CTNNB1 expression was downregulated compared with that in healthy controls.Taken together, our findings revealed that DANCR and miR-320a regulated the Wnt/β-catenin signaling pathway during osteogenic differentiation in osteoporosis through CTNNB1 inhibition. No 32778797 DANCR LncRNA Homo sapiens Carcinoma, Ductal, Breast Plasma Expression[lower expressed] qRT-PCR Plasma TINCR, HOTTIP, and SPRY4-IT1 upregulation and ANCR downregulation were observed in SSc patients compared with controls. No 32442909 DANCR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues regulation[miR-214-5p/CIZ1 axis] Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay LncRNA DANCR was upregulated in NSCLC. Downregulation of lncRNA DANCR inhibited cell proliferation and induced cell apoptosis in NSCLC by regulating the miR-214-5p/CIZ1 axis. No 32196604 D830024N08Rik-201 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[lower expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 16. No 30974198 cZFP609 LncRNA Homo sapiens Corneal Neovascularization corneas Expression[highly expressed] qPCR//Transwell Assay//Microarray qPCR detection showed that the ortholog of cZFP609 was significantly increased in the vascularized human corneas (Figs. 3A, B). By contrast, the ortholog of cKifap3 was significantly decreased in the vascularized human corneas No 31436645 CYTOR-225 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CYTOR LncRNA Homo sapiens Stomach Neoplasms GC tissue Expression[highly expressed] CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay Meanwhile, the level of HOTAIR, H19, PVT1, and LINC00152 was upregulated. No 32951010 CYTOR LncRNA Homo sapiens Stomach Neoplasms GC tissues regulation[ERK/MAPK Signaling Pathway] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Transwell Assay Compared with the normal tissues, higher expression of LINC00152 was found in GC tissues and LINC00152 was remarkably correlative with clinical stage and lymphatic metastasis. These results demonstrated that the interference of LINC00152 expression may inhibit the invasion and migration of GC cells by inhibiting the ERK/MAPK signaling pathway. Compared with the normal tissues, higher expression of LINC00152 was found in GC tissues and LINC00152 was remarkably correlative with clinical stage and lymphatic metastasis. No 32210577 CYTOR CircRNA Homo sapiens Breast Neoplasms blood ,tumor tissue Expression[highly expressed] qRT-PCR The results of the present study disclosed significantly increases in the CYTOR expression levels in tumor tissue with relative quantitation (RQ) equals to 5.15 (P<0.001) and in plasma (RQ =3.03, P<0.01) of breast cancer patients. No 32832487 CYTOR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CYTOR LncRNA Homo sapiens Colorectal Neoplasms CRC tumor tissues and cell lines Regulation[CYTOR/miR-3679-5p/ MACC1 Axis ] qRT-PCR Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) indicated that the expression of CYTOR was significantly elevated in CRC tumor tissues and cell lines.In addition, bioinformatics analysis revealed that there were 18 microRNAs (miRNAs) interacted with CYTOR, and one of them, miR-3679-5p might collaborate with metastasis-associated in colon cancer-1 (MACC1), which was selected for further analysis. Pearson correlation analysis showed a significant positive correlation between the expression levels of CYTOR and MACC1. In conclusion, this study suggested that lncRNA-CYTOR played an important role in tumorigenesis and development through the CYTOR/miR-3679-5p/MACC1 axis. Aberrant expression of CYTOR was significantly related to TNM stage, T stage, N stage, and perineural and venous invasions. Survival analysis indicated that high-CYTOR expression was associated with poor overall survival in CRC patients (p = 0.0057), and multivariate analysis showed that high-CYTOR expression was an independent prognostic factor, which led to poor OS. No 31144988 CYTOR LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Expression[highly expressed] qRT-PCR The expression of SNHG12 and LINC00152 were significantly higher in PTC tissues than in adjacent normal tissues not only in gene expression omnibus database but the validated samples. More interesting, LINC00152 expression level was also significantly higher in PTC tissues than that in benign thyroid nodules. The upregulation of LINC00152 and SNHG12 was associated with the malignant progression of PTC. Receiver operating characteristic curve analysis also demonstrated that there was a good trend, which indicates that they may have certain diagnostic value. No 31773972 CYTOR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR We found lncRNA NRAD1 and LINC00152 expressed significantly higher in HCC tissues compared with non-tumorous tissues. No 33116620 CYTOR LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR The levels of serum HULC, MALAT1, Linc00152, PTTG3P, SPRY4-IT1, UBE2CP3, and UCA1 were significantly higher in HCC patients than in patients with benign liver diseases and healthy controls, whereas serum PTENP1 was significantly decreased in HCC patients compared with healthy participants. No 32733618 CYTOR LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues and cell lines Regulation[miR-1182/CDK14 axis] MTT//ChIP//Transwell Assay In this study, LINC00152 was highly expressed in osteosarcoma tissues and cell lines.More importantly, mechanism investigation revealed that LINC00152 was predominantly located in the cytoplasm of OS cells and acted as a competing endogenous RNA (ceRNA) in OS by regulating miR-1182/CDK14 axis. Collectively, LINC00152 was activated by TCF3 and promotes cell proliferation and migration in osteosarcoma via miR-1182-CDK14 axis. No 30600185 CYTOR LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cell lines Regulation[miR-216b-5p/HOXA1 axis] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot LINC00152 was up-regulated in CC tissues and cell lines The high expression level of LINC00152 was positively correlated with poor prognosis and histologic grade in CC. No 31114990 CYTOR LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cells Regulation( TGF-β/SMAD3 signaling pathway) In Vivo Experiment//ChIP//Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Here, we screened long non-coding RNAs (lncRNAs) responsive to TGF-β and highly expressed in LUAD cells, and finally obtained our master molecular LINC00152. We proved that the TGF-β promoted transcription of LINC00152 through the classical TGF-β/SMAD3 signaling pathway and maintained its stability through the RNA-binding protein HuR. Moreover, LINC00152 increased ZEB1, SNAI1 and SNAI2 expression via increasing the interactions of HuR and these transcription factors, ultimately promoting epithelial-mesenchymal transition of LUAD cell and enhancing LUAD metastasis in vivo. No 36071042 DARS1-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cytoprotective Interaction(DARS ) RNA Pull-Down//Western Blot//Transfection//MeRIP//CCK8//qRT-PCR//FISH//IF//RIP//Luciferase Report Assay//ChIP Higher DARS-AS1 expression was found in CC tissues and cytoprotective. We also uncovered that hypoxic exposure induced cytoprotective autophagy via HIF1α/DARS-AS1/DARS axis. Moreover, DARS-AS1 was validated to facilitate DARS translation via recruiting N6-adenosine-methyltransferase methyltransferase like 3 (METTL3) and methyltransferase like 14 (METTL14), which bound with DARS mRNA DARS mRNA 5' untranslated region (5'UTR) and promoting its translation. The present study demonstrated that the 'HIF1α/DARS-AS1/DARS/ATG5/ATG3' pathway regulated the hypoxia-induced cytoprotective autophagy of CC and might be a promising target of therapeutic strategies for patients afflicted with CC. No 35638109 DBH-AS1 LncRNA Homo sapiens COVID-19 COVID-19 patients Expression(lower expressed) qRT-PCR Results revealed the decreased expression of A2M-AS1 and FLVCR1 in COVID-19 patients. Additionally, they showed the increased expression of DBH-AS1, FLVCR1-DT, and NCBP2AS2. Both FLVCR1-DT and NCBP2AS2 showed a positive correlation with interleukin-6 (IL-6). DBH-AS1 and FLVCR1-DT had a significant association with mortality, complications, and mechanical ventilation. A significant negative correlation was found between A2M-AS1 and NCBP2AS2-1 and between FLVCR1 and FLVCR1-DT. No 36359290 CYTOR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC tissues,cell lines Expression[highly expressed] qRT-PCR The relative expression level of LINC00152 was over-expressed in LSCC cell lines and cancerous tissues than that in paired adjacent normal tissues, and the difference was statistically significant（P=0.006） Even the associations between LINC00152 expression level and clinicopathological features（P=0.044 for clinical stage, P=0.032 for pathological differentiation degree） were significantly. No 31446726 DCDC2C-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 DIP2A-IT1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 917 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 DIO3OS LncRNA Homo sapiens Uterine Cervical Neoplasms cervical carcinoma tissues Expression[lower expressed] qRT-PCR//Microarray CACX is one of the most common cancer affecting women world-wide. Here, expression microarray analysis revealed 8 over-expressed transcribed pseudogenes (GBP1P1, HLA-DRB6, HLA-H, SLC6A10P, NAPSB, KRT16P2, PTTG3P and RNF126P1), down-regulated 7 lincRNAs (H19, MIR100HG, MEG3, DIO3OS, HOXA11-AS, CD27-AS1 and EPB41L4A-AS) and 6 snoRNAs (SNORD97, SNORD3A, SNORD3C, SNORD3D, SNORA12 and SCARNA9) as DEncGs (log2 fold-change ≥ ±1.0) in CACX. No 31229557 DIO2-208 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 DICER-AS1 LncRNA Homo sapiens stomach carcinoma gastric cancer tissues Expression[lower expressed] qRT-PCR Expression of DICER-AS1 was significantly down-regulated in gastric cancer tissues compared with the corresponding non-cancerous tissues (Expression ratio = 0.23, P value = .01). No 32663487 DICER1-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Expression[highly expressed] qRT-PCR It was found that the expression levels of DICER1-AS1 in osteosarcoma tissues were significantly higher than those in corresponding noncancerous bone tissues (p < 0.01). Higher DICER1-AS1 had significant association with clinical stage (p = 0.005) and distant metastasis (p = 0.000). Kaplan-Meier survival analysis showed that patients with high DICER1-AS1 expression had a shorter OS and DFS compared with the low DICER1-AS1 expression group (p = 0.007 and p < 0.0001). No 30536305 DGCR5 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)96) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 DGCR5 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,blood Expression[lower expressed] qRT-PCR QRT-PCR analysis was taken to detect relative expression of X91348 in tissue and serum samples. As shown in Figure 1, the average expression level of X91348 was lower in tumour tissues than in adjacent non-cancerous ones (0.463 vs. 0.695, p < .001). Meanwhile, detection results on serum sample demonstrated that X91348 expression exhibited an increasing tendency in HCC patients compared with healthy people (0.371 vs. 0.821, p < .05, Figure 2). No 31349749 DGCR5 LncRNA Homo sapiens Pancreatic Neoplasms PaCa tissues and cells regulation[p38 MAPK pathway] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Western Blot lncRNA DGCR5 was found to be downregulated in PaCa tissues and cells.On the whole, the findings of the present study indicate that lncRNA DGCR5 upregulates the BNIP3 and p38 MAPK pathways via miR‑27a‑3p to promote PaCa cell apoptosis, thereby attenuating PaCa development. No 32626951 DESI2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DESI1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 DEPDC1P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 854 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 DENND5B-AS1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 DENND4A CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 DENND2C LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)25) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 DENND1A CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 DEC1-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 DDX59-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression(highly expressed) qRT-PCR High expression of DDX59-AS1 was significantly correlated with T stage, clinical stage, race, and age (p < 0.05).The expression of DDX59-AS1 was negatively correlated with Mast cells, Tfh, T cells, Treg, and B cells, and positively related with the Tgd infiltration level. High expression of DDX59-AS1 was significantly correlated with T stage, clinical stage, race, and age (p < 0.05).Multivariate survival analysis demonstrated that the high expression of DDX59-AS1 was associated with lower overall and specific survival rates. The prognosis prediction was validated by the nomogram and calibration curves. No 36081993 DDX56-208 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[lower expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 DDX5-233 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 DDX50P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 605 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 DDX3X-240 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 DDX17-210 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 DDX17-201 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 DDX12P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 DDX11L11 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 DDX11-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC specimens Expression(highly expressed) qRT-PCR We found that the levels of DDX11-AS1 were higher in HCC specimens than in normal specimens. According to the results of clinical tests, a high level of DDX11-AS1 expressions was significantly related to the pathologic stage (p=0.015) and the histologic grade (p < 0.001). Survival studies indicated that patients with higher DDX11-AS1 expression had a significantly poorer overall survival (p=0.005) and progression-free interval (p=0.003) than those with lower DDX11-AS1 expression. No 36072974 DDX11-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms cell line regulation[miR-2355-5p/LAMB3 axis] Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//RIP//EdU Staining DDX11-AS1 manifested remarkably high level in BC and promoted the malignancy of BC.DDX11-AS1 facilitates the tumorigenesis of BC by the miR-2355-5p/LAMB3 axis. No 32412777 DDR1-DT-206 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[highly expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 DCTPP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CYTOR LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissue and cells Interaction[PTEN ] ChIP//Western Blot//Co-IP//Colony Formation Assay//qRT-PCR//FISH//Luciferase Report Assay//IHC//Transwell Assay In our study, we identified that LINC00152 expression was dramatically elevated in TNBC tissue and cells. Consequently, this study firstly reveals that up-regulated LINC00152 mediates PTEN protein stability attenuation in TNBC. Furthermore, analysis of clinical samples resource retrieved from databases suggested high LINC00152 expression was correlated with ER or PR negative expression, late TNM stage and lymphatic invasion, as well as shorter overall survival time in patients.  No 30594392 CYRIB-204 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 CR616125 LncRNA Homo sapiens Arthritis, Gouty blood Expression[lower expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 CTC-297N7.9 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Expression[lower expressed] PCR The expression of CTC-297N7.9 was downregulated in HCC cell lines and HCC tissues. ROC curve revealed its significant diagnostic value in HCC. CTC-297N7.9 expression correlated with serum alpha-fetal protein (AFP), tumor stage, and tumor differentiation. Survival analysis indicated that overall survival (OS) and disease-free survival (DFS) are all positively associated with CTC-297N7.9 expression, especially in patients without viral hepatitis or cirrhosis. Cox regression analysis showed that CTC-297N7.9 expression level is an independent prognostic factor for both OS and DFS in HCC patients. No 31674731 CTC-297N7 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 CTBP1-AS LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CTB-91J4.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 CTB-61M7.2 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[lower expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 CTB-161C1.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 CTB-138E5.1 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[highly expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 CT70 LncRNA Homo sapiens non-alcoholic steatohepatitis blood Expression[highly expressed] qRT-PCR The expression of plasma LeXis was significantly higher in patients with NASH than in those with NAFL (8.2 (5.0-14.9); 4.6 (4.0-6.6), p = 0.025). No 33022942 CSTF3-DT-202 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CSRNP2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CSPP1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 cSMARCA5 CircRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues and cell lines interaction[microRNA-432 ] qRT-PCR In the present study, cSMARCA5 expression was upregulated in cervical cancer tissues and cell lines.In conclusion, the present findings suggested that cSMARCA5 may play an important role in the progression of cervical cancer via the ERK signaling pathway by modulating miR‑432. No 31922210 CSGALNACT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CSE1L LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CRYZP2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 743 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 CRTC3 LncRNA Homo sapiens Colorectal Neoplasms 2474 CRC cases Interaction(rs10161980, rs7495132 ) Other We found that the TT genotype of the intron variant rs7495132 in the CRTC3 gene was associated with clinically relevant poorer CRC-specific survival in both the discovery (hazard ratio [HR] = 1.97, 95% confidence interval [CI] = 1.41-2.74, P = 6.1 × 10-5 ) and validation analysis (HR = 1.69, 95% CI = 1.03-2.79, P = .038). In addition, the GG genotype of rs10161980 (intronic variant of AL139383.1 lncRNA) was associated with worse overall survival in the discovery cohort (HR = 1.24, 95% CI = 1.10-1.39, P = 3.4 × 10-4 ) and CRC-specific survival in the validation cohort (HR = 1.26, 95% CI = 1.01-1.56, P = .040). We found that the TT genotype of the intron variant rs7495132 in the CRTC3 gene was associated with clinically relevant poorer CRC-specific survival in both the discovery (hazard ratio [HR] = 1.97, 95% confidence interval [CI] = 1.41-2.74, P = 6.1 × 10-5 ) and validation analysis (HR = 1.69, 95% CI = 1.03-2.79, P = .038). In addition, the GG genotype of rs10161980 (intronic variant of AL139383.1 lncRNA) was associated with worse overall survival in the discovery cohort (HR = 1.24, 95% CI = 1.10-1.39, P = 3.4 × 10-4 ) and CRC-specific survival in the validation cohort (HR = 1.26, 95% CI = 1.01-1.56, P = .040). No 33411955 CRSP8P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CRNDE-204 LncRNA Homo sapiens Adrenocortical Carcinoma ACC tissues Expression[highly expressed] qRT-PCR//Microarray In these samples, 874 lncRNAs were differentially expressed in ACC compared with NAC, of which 409 were upregulated, and 465 were downregulated. The 874 differentially expressed lncRNAs corresponded to 330 annotated lncRNA genes. Among the upregulated lncRNAs, the greatest log2 fold change was 8.5 for an unannotated lncRNA gene, and RAD50 was the geratest upregulated, annotated lncRNA gene with a log2 fold change of 6.1. Among the downregulated lncRNAs, the greatest log2 fold change was 8.3 for an unannotated lncRNA gene and 6.4 for HAND2, the greatest downregulated annotated lncRNA gene; of these, 183 differently expressed lncRNAs had established functions in cancer development and cancer progression. Selected carcinogenesis-related lncRNAs are summarized in Table 2. No 31522749 CRNDE LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patients Regulation Bioinformatics Analysis We identified and independently verified the ATG (AL691432.2, MMP2-AS1, AC124067.2, CRNDE, ABALON, AL161431.1, NKILA) in NSCLC patients and found that immune regulation in the tumor microenvironment is closely related to this gene. No 34849558 CRNDE LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Expression[highly expressed] qRT-PCR The resulted revealed that CRNDE was significantly overexpressed in HCC tissues and cell lines, and was statistically correlated with poor clinical outcome. The resulted revealed that CRNDE was significantly overexpressed in HCC tissues and cell lines, and was statistically correlated with poor clinical outcome. No 32826865 CRNDE LncRNA Homo sapiens Carcinoma, Hepatocellular serum exosomal Expression(highly expressed) qRT-PCR The serum exosomal lncRNA CRNDE expression levels were significantly increased in patients with HCC compared with normal controls. High serum exosomal lncRNA CRNDE expression was significantly associated with tumor size, tumor differentiation, and TNM stage. No 34612554 CRNDE LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis CRNDE was confirmed an oncogene, and its up-regulated expression significantly correlated with poor prognosis and advanced tumor progression. No 30509091 CRNDE LncRNA Homo sapiens Leukemia, Myeloid, Acute blood Expression(highly expressed) Bioinformatics Analysis Upregulated CRNDE expression was independently associated with lower complete remission (CR) rates in the whole cohort of AML (P < .001). AOX2P overexpression was identified as an independent adverse prognostic marker for CR in the CN-AML (P = .009) and non-t (15;17) AML (P < .001) subgroups. Patients with high CRNDE expression had a significantly shorter event-free survival (EFS, whole cohort of AML: P = .017; CN-AML: P = .001; non-t (15;17) AML: P = .006) and inferior overall survival (OS, whole cohort of AML: P = .002; t(15;17) AML: P = .001) than those with low CRNDE expression. EFS and OS did not differ significantly between patients with high AOX2P expression and those with low expression. Upregulated CRNDE expression was independently associated with lower complete remission (CR) rates in the whole cohort of AML (P < .001). AOX2P overexpression was identified as an independent adverse prognostic marker for CR in the CN-AML (P = .009) and non-t (15;17) AML (P < .001) subgroups. Patients with high CRNDE expression had a significantly shorter event-free survival (EFS, whole cohort of AML: P = .017; CN-AML: P = .001; non-t (15;17) AML: P = .006) and inferior overall survival (OS, whole cohort of AML: P = .002; t(15;17) AML: P = .001) than those with low CRNDE expression. EFS and OS did not differ significantly between patients with high AOX2P expression and those with low expression. No 34129278 CRNDE LncRNA Homo sapiens Sepsis blood Interaction[ sponging miR-181a-5p] qRT-PCR//Luciferase Report Assay//Western Blot The sepsis patients displayed higher CRNDE expression and lower miR-181a-5p expression than healthy controls (P < 0.05) (Figure 1a). No 31604377 CRNDE LncRNA Homo sapiens Sepsis blood interaction[TLR3] qRT-PCR LncRNA CRNDE was upregulated in sepsis patients compared with HCs, and it showed good value in differentiating sepsis patients form HCs by receiver operating characteristic curve analysis. LncRNA CRNDE interacts with TLR3, both of which correlate with advanced disease severity, inflammation, and higher 28-days mortality in sepsis patients. No 32696505 CRNDE LncRNA Homo sapiens Hepatoblastoma HB tissues regulation[MiR-203/VEGFA Axis] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay Our data revealed that miR-203 expression was decreased in HB tissues, while long non-coding RNA (lncRNA) CRNDE expression was increased. lncRNA CRNDE targets the miR-203/VEGFA axis and promotes angiogenesis in HB. The dysregulation of miR-203 and CRNDE was closely related to tumour size and stage. No 32182608 Crnde LncRNA Mus musculus Sepsis-Associated Renal Injury kidney tissues Regulation[TLR3/NF-κB pathway] qRT-PCR//Western Blot//Tunel//H&E Staining Compared with the Sham group, lncRNA CRNDE level in the kidney of the LPS group was remarkably up-regulated (p<0.05). Inhibition of CRNDE can reduce sepsis-induced KI by blocking the activation of the TLR3/NF-κB pathway. Moreover, CRNDE is expected to become a target for clinical treatment of sepsis-related KI. No 31841203 CRMA LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CRIP2-207 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 CTC-297N7.9 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC and para-carcinoma tissues Expression[Expression[lower expressed]-expression] qRT-PCR//Microarray The qRT-PCR assay showed the Expression[Expression[up-expression]-expression]regulation of miR-455-5p, miR-21-3p, miR-96-5p, miR-93-5p, RP11-973H7.5, and HOXC10 expression in LSCC as well as the Expression[down-expression]regulation of miR-486-5p, LINC00657, CTC-297N7.9, hsa_circ_0008832, hsa_circ_0033988, hsa_circ_0001445, hsa_circ_0007013, KRT4, HOPX, TGFBR2, and KDR expression in LSCC (Fig. 9). No 30128795 CTC-497E21.4 LncRNA Homo sapiens Stomach Neoplasms serum Expression[highly expressed] qRT-PCR confirmation of the higher lncRNA CTC-497E21.4 expression in different types of GC specimens than corresponding controls No 30763257 CYRIB LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CTC-529L17.2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 CYP4F35P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CYP4F29P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CYP4F24P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CYP4A22‐AS1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)98) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 CYP4A11 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CYP2T1P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CYP2J2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CYP27B LncRNA Homo sapiens COVID-19 peripheral blood Regulation qRT-PCR Expression of SNHG6 was considerably lower in COVID-19 patients compared with control subjects (Ratio of mean expression (RME) = 0.22, P value = 7.04E-05) and in both female and male COVID-19 patients compared with sex-matched unaffected individuals (RME = 0.32, P value = 0.04 and RME = 0.16, P value = 0.000679683, respectively). However, its expression was similar among ICU-hospitalized and non-ICU patients. Similarly, expression of SNHG16 was lower in in COVID-19 patients compared with controls (RME = 0.20, P value = 5.94E-05) and in both female and male patients compared with sex-matched controls (RME = 0.32, P value = 0.04 and RME = 0.14, P value = 0.000496435, respectively) with no significant difference among ICU-hospitalized and non-ICU hospitalized patients. Expression of VDR was lower in COVID-19 patients compared with controls (RME = 0.42, P value = 0.04) and in male patients compared with male controls (RME = 0.27, P value = 0.02). Yet, expression of VDR was statistically similar between female subgroups and between ICU-hospitalized and non-ICU hospitalized patients. Expression levels CYP27B, Linc00511 and Linc00346 were similar among COVID-19 patients and healthy subjects or between their subgroups. Significant correlations have been detected between expression levels of VDR, CYP27B and SNHG6, SNHG16, Linc00511 and Linc00346 lncRNAs both among COVID-19 patients and among healthy controls with the most significant ones being SNHG6 and SNHG16 (r = 0.74, P value = 3.26e-17 and r = 0.81, P = 1.54e-22, respectively). No 34147082 CYP21A1P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CXXC4-AS1 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial 35 cases of EOC patients (malignant group) and 20 cases of benign ovarian tumor patients (benign group) Expression(lower expressed) qRT-PCR Compared with the benign and normal groups, the expression of FER1L6-AS2, LINC00470 and LINC01811 in malignant group increased by 1.66 and 1.84-fold, 2.05 and 2.46-fold, 2.94 and 2.35-fold, respectively; the expressions of CXXC4-AS1, LINC02343 and LINC02428 were down-regulated to 29% and 34%, 40% and 46%, 42% and 42%, respectively. No 35385957 CXCR2P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CTSH-215 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CTPS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CTDSPL CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 CTDHUT LncRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] Microarray A two-stage validation revealed that plasma levels of three lncRNAs (FAM49B-AS, GUSBP11, and CTDHUT) were significantly higher in GC plasma as compared with healthy controls (P < 0.05), and the combined area under curve of these lncRNAs was 0.818 (95% CI 0.772-0.864). No 30603909 CTD-3154 N5.2 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[lower expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 CTD-3064M3.3 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[lower expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 CTD-2881E23.2 LncRNA Homo sapiens Neuroblastoma Neuroblastoma tissues Expression[Expression[highly expressed]-expression] ChIP-seq//RNA-seq Differential analysis revealed nine significantly differentially expressed (more than 2-fold change with corrected p-value) lncRNAs between tumor cells and matched MNCs. Of these, RFPL1S (p = 0.0001), PPP1R26-AS1 (p = 0.03), RP11-439E19.3 (p = 1.24 × 10–6), CASC15 (p = 1.6 × 10–7), AC004540.5 (p = 0.0002), and CTD-2881E23.2 (p = 1.6 × 10–9) were found to be significantly Expression[up-expression]regulated (Figure 1B), while USP3-AS1 (p = 1.78 × 10–6), CHRM3-AS2 (p = 0.003) and RP6-99M1.2 (p = 0.002) were significantly downregulated (Figure 1C). No 31920530 CTD-2562J17.6 LncRNA Homo sapiens lung squamous cell carcinoma LUSC samples Expression[lower expressed] CCK8//Colony Formation Assay//Flow Cytometry//Western Blot Our results showed that CTD-2562J17.6 and FENDRR were significantly downregulated while MIR205HG, LNC_000378, RP11-116G8.5, RP3-523K23.2, and RP5-968D22.1 were significantly upregulated in all five LUSC samples. Importantly, MIR205HG was upregulated in LUSC clinical samples as well as in LUSC cell lines. No 32188965 CTD-2510F5.4 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[highly expressed] CCK8//qRT-PCR//ISH We then detected the expression level of CTD-2510F5.4 in 90 paired gastric cancer tissues and adjacent-normal gastric tissues by ISH. CTD-2510F5.4 expression was observed in nuclei and cytoplasm (Fig. S3a). Significantly higher expression level of CTD-2510F5.4 was detected in the gastric cancer tissues (159.6%, 119.6–174%) than in the normal tissues (98.2%, 62–132.2%) (p < 0.01), suggesting CTD-2510F5.4 may be a potential biomarker for gastric cancer (Fig. S3b). CTD-2510F5.4 expression was significantly higher in gastric cancers, and was correlated with pathological grade, vascular or nerve invasion, AJCC TNM stage and OS. No 30560474 CTD-2353F22.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 CTD-2336O2.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 CTD‐2315E11.1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)39) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 CTD‐2269F5.1 LncRNA Homo sapiens Colonic Neoplasms COAD tissues Expression[lower expressed] qRT-PCR "To manifest the expression of integrated analysis, we selected the previously obtained eight biomarkers including XXbac‐ B476C20.9, PP7080, CDKN2B‐AS1, LINC00092, CA3‐AS1, HAND2‐AS1, CTD‐2269F5.1, and LINC01082. In Figure 8, these eight selected DElncRNAs for qRT‐PCR confirmation were eight optimal diagnostic lncRNA biomarkers, and these eight DElncRNAs were all downregulated in the high‐ throughput transcriptome datasets for COAD compared with normal controls. The expression of these selected eight genes in qRT‐PCR was consistent with our integrated analysis." No 30269368 CTD-2249K22.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 CTD‐2194A8.2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)79) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 CTD-2090I13.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 CTD‐2061E19.1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)47) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 CTD-2020K17.1 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[differently-expression] qRT-PCR//Microarray "The identified 199 lncRNAs were then analysed, retaining only those transcripts for which experimentally validated microRNA (miRNA) targets had already been annotated in starBase and, among these, only lncRNAs that targeted at least 10 miRNAs were selected. Using this approach, we obtained 6 lncRNAs, including CTD-2020K17.1, LINC00657, RP11-169K16.9, LINC00511, RP11-372K14.2 and RP11-214O1.2. (Table 2)" No 31480511 EZH1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 F11-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Epigenetics(hypo-methylated ) qRT-PCR//Bioinformatics Analysis Significant negative correlation was observed between 8 DElncRNAs-DMCs pairs. 3 (cg23614229, cg23957912, and cg11052780) DMCs and 4 (CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1) DElncRNAs were identified as high-risk factors for poor prognosis of PC patients. Overexpression of hypo-methylated CACNA1G-AS1, F11-AS1, and NNT-AS1 and down-regulation of hyper-methylated MSC-AS1 significantly lower the survival of PC patients and could be a potential prognostic and therapeutic biomarker. No 35715447 FA2H-2 LncRNA Homo sapiens Coronary Disease plasma of CHD patients Expression [lower expressed] qRT-PCR//ELISA LncRNA-FA2H-2 relative expression in the CHD group was significantly downregulated (P < 0.001).The expression of LncRNA-FA2H-2 was reduced and inversely correlated with inflammation-related factors in CHD patients.  The differences in the expression levels of LncRNA-FA2H-2 were statistically significant between the two comparative analyses (P < 0.01), except between the 2-branch lesion and 3-branch lesion groups. No 34235188 H19 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR The expression level of lncRNA NEAT1, H19, MALAT1, HOTAIR, DANCR, UCA1, and BCAR4 were significantly decreased, compared with that in adjacent noncancerous tissues (all P <.05). The expression level of lncRNA GAS5 was statistically significantly increased (P <.05). For the quantitative polymerase chain reaction (qPCR) assay, 8 kinds of lncRNAs were detected as a result of the GeXP assay. No 30423146 H19 LncRNA Homo sapiens Carcinoma, Hepatocellular tumorous Interaction(microRNA-675) qRT-PCR Our results showed that the expression of lncRNA-H19 and microRNA-675 were higher in patients than in controls (p < 0.001 for both). Additionally, lncRNA-H19 expression was higher in tumorous than in non-tumorous tissue (p < 0.001). Linear regression revealed that miR-675 expression was a significantly higher positive predictor than lncRNA-H19 for tumor size, pathologic grade, and AFP level; similarly, for cyclin D1 and VEGF protein expression. No 36671388 H19 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Mutation[rs217727,rs2735971,rs3024270] Other We analyzed the frequency of three lncRNA H19 SNPs in 200 bladder cancer patients and 200 healthy controls. Carriers of variant rs217727 heterozygous genotype showed increased bladder cancer risk (P=0.008). Further stratified analyses revealed that the association between bladder cancer risk and variant genotypes of rs217727 was more profound in smokers. Furthermore, decreased risk of invasive bladder cancer was found in carrying rs3024270 CC patients. No 29595036 H19 LncRNA Homo sapiens Gastrointestinal Stromal Tumors GIST and adjacent tissue Expression[highly expressed] RNA-seq However, only H19 and FENDRR showed significant upregulation in the validation cohort (adjusted p < 0.05). No 30557328 H19 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] qRT-PCR Importantly, expression of MALAT1 and H19 was down-regulated in tumor tissues of 62.5 % and 81.25 % respectively of OSCC patients. No 33410422 H19 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck Expression [highly expressed] qRT-PCR lncRNA H19 was highly expressed and its promoter region was hypomethylated in OSSC cell lines as compared to normal control. Almost all OSCC patients tissues (63 out of 65, 97 %) showed hypomethylation of lncRNA H19 compared to normal oral mucosa tissues. There was a significant correlation between methylation ratio and tumor histopathologic grade. OSCC patients with hypomethylation of lncRNA H19 had a significantly lower 5-year survival rate. No 34333230 H19 LncRNA Homo sapiens colorectal adenocarcinoma CRA and adjacent normal tissues Regulation[H19/miR-194/FoxM1 axis] qRT-PCR//Wound Healing Assay//Luciferase Report Assay//Transwell Assay Highly-expressed H19, lowly-expressed miR-194-5p, low-grade differentiation and lymph node metastasis appeared as the independent predictors of unfavorable prognosis in CRA patients' (all P< 0.05).LncRNA H19/miR-194/FoxM1 axis could serve as a profound target for the diagnosis and treatment of CRA. Highly-expressed H19, lowly-expressed miR-194-5p, low-grade differentiation and lymph node metastasis appeared as the independent predictors of unfavorable prognosis in CRA patients' (all P< 0.05). No 30278464 H19 LncRNA Homo sapiens Endometrial Neoplasms endometrial cancer tissues interaction[miR-612] CCK8//qRT-PCR//Western Blot The expression of lncRNA H19 and HOXA10 was high in endometrial carcinoma and miR-612 was lowly expressed. The high expression of lncRNA H19 in endometrial carcinoma may regulate the expression level of its target gene HOXA10 by targeting miR-612, thus promoting cell proliferation to play a role in the development of endometrial carcinoma. The survival curve suggested that lncRNA H19 was negatively correlated with patient survival. No 30070313 H19 LncRNA Homo sapiens Neoplasms Mutation[rs217727 ] Meta-analysis A total of 17 case-control publications were selected. This meta-analysis showed that H19 rs217727 has a significant increased association with cancer risk in allelic, homozygous, heterozygote, dominant and recessive models (T vs C: OR = 1.16, 95% CI = 1.06-1.27, I2 = 75.7; TT vs CC: OR = 1.29, 95% CI = 1.06-1.56, I2 = 71.6; CT vs CC: OR = 1.15, 95% CI = 1.01-1.31, I2 = 75.4; CT + TT vs CC: OR = 1.20, 95% CI = 1.05-1.36, I2 = 76.5; TT vs CT + CC: OR = 1.22, 95% CI = 1.02-1.45, I2 = 70.6;). In the subgroup analysis of smoking status, both smokers and nonsmokers showed an increase in cancer risk in allelic, homozygous, dominant and heterozygote models. No 31752724 H19 LncRNA Homo sapiens Glioma cancer tissues and serum Expression[highly expressed] qRT-PCR Compared with adjacent tissues (5.19 ± 1.42), H19 level in cancer tissues (7.45 ± 1.60) and serum (6.44 ± 1.57) was significantly increased (P < 0.05). Compared with serum, H19 level in cancer tissues was significantly increased (P < 0.05). No 32586100 H19 LncRNA Homo sapiens Glioblastoma RNA Regulation(H19-hsa-miR-338-3P-NRP1 regulatory pathway) qRT-PCR With multiple optimization mRNAs, we found the H19-hsa-miR-338-3P-NRP1 regulatory pathway. Additionally, we noted high NRP1 expression in GBM patients, and Kaplan-Meier and ROC analyses showed that NRP1 expression was associated with GBM prognosis. Cox analysis indicated that NRP1 is an independent prognostic factor in GBM patients. In conclusion, H19 and hsa-miR-338-3P regulate NRP1 expression, and this pathway plays an important role in GBM. Additionally, we noted high NRP1 expression in GBM patients, and Kaplan-Meier and ROC analyses showed that NRP1 expression was associated with GBM prognosis. Cox analysis indicated that NRP1 is an independent prognostic factor in GBM patients. No 34843522 H19 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Expression[lower expressed] qRT-PCR Expression of H19 was lower in the PTC tissues (1.259 ± 1.15) compared to the BNT tissues (2.8347 ± 2.176) (p= 0.001). Low expression of H19 was associated with patient's age, tumor size, extrathyroid extension, pathological lateral node metastasis (pN1b), histological aggressive type and poorer disease-free survival (p< 0.0001). No 31403942 H19 LncRNA Homo sapiens Diabetes Mellitus, Type 2 blood Expression[lower expressed] qRT-PCR It was observed that type 2 diabetic patients had decreased [0.59 fold] lncRNA H19 expression while increased miRNA-29a [5.62 fold] and miRNA-29b [5.58 fold] expression. No 33116722 H19 LncRNA Homo sapiens Thyroid Neoplasms THCA tissues Regulation qRT-PCR//Microarray LncRNA H19 was differentially expressed in various cancers and also remarkably downregulated in the THCA tissues compared to the normal ones. In addition, H19 expression was positively correlated with infiltration level of diverse immune cells including CD4+T cells, CD8+T cells, B cells, dendritic cells, neutrophils and macrophages and was closely associated with multiple immune markers in THCA. Genetic alteration analysis revealed that there was a significant correlation between alterations in H19 and overall survival of THCA patients. No 35810257 H19 LncRNA Homo sapiens acute myocardial infarction blood Expression[highly expressed] qRT-PCR Out of the 10 lncRNAs tested, the mRNA level of lncRNA H19, MIAT and MALAT1 were significantly higher in AMI patients than in healthy control (2.3 ± 0.2 vs. 1.0 ± 0.1, p < 0.001, 1.5±0.1 vs. 1.0±0.1, p = 0.002, 1.8±0.2 vs. 1.0±0.1, p < 0.001, respectively). No 31302423 H19 LncRNA Homo sapiens Coronary Artery Disease blood Expression[highly expressed] qRT-PCR The subsequent result indicated that the H19 lncRNA was over-expressed in CAD patients in comparison with the controls. No 30124004 H19 LncRNA Homo sapiens Coronary Artery Disease Blood Interaction[TGF-β1] qRT-PCR//ELISA//Western Blot The results of H19 expression were specifically upregulated in patients with CAD but not in healthy individuals and patients with other types of cardiovascular diseases.H19 expression was positively correlated with the serum level of TGF-β1, and H19 overexpression significantly increased TGF-β1 protein level in HCAEC. No 30892430 H19 LncRNA Homo sapiens Coronary Artery Disease peripheral blood of CAD patients Mutation qRT-PCR//Genotyping We detected an upregulated expression of lncRNA H19 in the peripheral blood of CAD patients compared with healthy controls, and the area under the receiver operating characteristic curve of lncRNA H19 for CAD diagnosis was 0.918. In addition, rs4929984 was associated with the susceptibility of Han Chinese females to CAD, as shown in the additive and dominant models, and the significant association remained after adjusting for age and Bonferroni correction. The A allele carriers of rs4929984 were correlated with females' susceptibility to CAD compared with the C allele, and the A-G haplotype of rs4929984-rs217727 was associated with females' susceptibility to CAD. No 33826032 H19 LncRNA Homo sapiens Precursor Cell Lymphoblastic Leukemia-Lymphoma diagnosed patients Interaction(miR-326) qRT-PCR lncRNA H19 was identified as an oncogenic factor which was noticeably increased in the newly diagnosed patients (P = 0.0019, AUC = 0.84) and negatively associated with miR-326 (r = -0.6, P = 0.02). No 33580459 H19 LncRNA Homo sapiens Sepsis peripheral blood Expression(lower expressed) qRT-PCR Compared with the control group, the expression of peripheral blood H19 in the disease group was significantly down-regulated. The expression of H19 in the survival group was significantly up-regulated compared with that in the death group, and the AUC in the survival group was 0.865. No 34017457 H19 LncRNA Homo sapiens Liver Neoplasms 944 samples composed of 472 HCC patients and 472 matched controls Epigenetics(rs2839698, rs3024270 ,rs2735971) Genotyping The TT + CT genotype of rs2839698 was found to be associated with a 1.32-fold increased HCC risk (P=0.037, 95% confidence interval (CI) = 1.02-1.70). In the stratified analysis, rs2839698 (odds ratio (OR) = 1.57, P=0.007, 95% CI = 1.13-2.18) and rs3024270 (OR = 1.71, P=0.019, 95% CI = 1.09-2.68) were found to show more obvious increased HCC risk in the age ≤60 subgroup. And we found that rs2839698 showed an increased HCC risk in the ever smoking subgroup. But in the male subgroup of rs2735971, it showed a decreased HCC risk. Furthermore, haplotype analysis showed that rs2735971-rs2839698-rs3024270 G-T-C significantly increased the risk of HCC (OR = 1.23, 95% CI = 1.01-1.51, P=0.043). Multilogistic analysis revealed no significant results of the interaction effects of the SNPs and environment factors. And in our study, rs2839698 showed a significant poor prognosis in the ever smoking subgroup (hazard rate (HR) = 5.19, 95% CI = 1.12-24.07, P=0.035). No 29511035 H19 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissue Regulation[Expression[highly expressed]-regulated] ISH While no LncH19 expression in the tumor adjacent to normal epithelia was disclosed with the technology, significantly higher levels of LncH19 expression were detected in the tumors obtained from the patients who died within one year after surgery, compared to the expression in those tumors from the patients who survived longer than five years after the same treatment regimen (P = 0.001). In addition, LncH19 expression was verified to correlate with a larger tumor size (P = 0.002) and a higher UICC stage (P = 0.001). While no LncH19 expression in the tumor adjacent to normal epithelia was disclosed with the technology, significantly higher levels of LncH19 expression were detected in the tumors obtained from the patients who died within one year after surgery, compared to the expression in those tumors from the patients who survived longer than five years after the same treatment regimen (P = 0.001). In addition, LncH19 expression was verified to correlate with a larger tumor size (P = 0.002) and a higher UICC stage (P = 0.001). No 31551175 H19 LncRNA Homo sapiens Hepatoblastoma Mutation[rs2839698, rs3024270 and rs217727 ] Genotyping Overall, the H19 rs2839698, rs3024270 and rs217727 polymorphisms were associated with hepatoblastoma susceptibility in a Chinese Han population. No 33236528 H19 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical carcinoma tissues Expression[lower expressed] qRT-PCR//Microarray CACX is one of the most common cancer affecting women world-wide. Here, expression microarray analysis revealed 8 over-expressed transcribed pseudogenes (GBP1P1, HLA-DRB6, HLA-H, SLC6A10P, NAPSB, KRT16P2, PTTG3P and RNF126P1), down-regulated 7 lincRNAs (H19, MIR100HG, MEG3, DIO3OS, HOXA11-AS, CD27-AS1 and EPB41L4A-AS) and 6 snoRNAs (SNORD97, SNORD3A, SNORD3C, SNORD3D, SNORA12 and SCARNA9) as DEncGs (log2 fold-change ≥ ±1.0) in CACX. No 31229557 H19 LncRNA Homo sapiens Neuroblastoma Mutation[rs2839698,rs3024270 ,rs217727 ] Genotyping We hypothesize that single nucleotide polymorphisms (SNPs) in the H19 gene might predispose to neuroblastoma. Here, we genotyped three SNPs (rs2839698 G>A, rs3024270 C>G, rs217727 G>A) from H19 gene in a Chinese population (700 subjects with neuroblastoma and 1516 control subjects) enrolled from six hospitals and examined the effect of individual and combined SNPs on the risk of neuroblastoma. Odds ratios (ORs) and 95% confidence intervals (CIs) calculated from logistic regression were adopted to assess such association, adjusted for age and gender. Among them, 700 controls and 1514 cases were successfully genotyped. None of these three SNPs were found to be relevant to the risk of neuroblastoma, either in overall analysis or stratification analysis. No 31772668 H19 LncRNA Homo sapiens Peptic Ulcer blood Expression[highly expressed] qRT-PCR As regards miR-204 and miR-182, they were significantly increased (12.5 and 2.6 folds, respectively) in GU samples, compared with those of healthy control levels. The elevated levels of these miRNAs were significantly de-escalated in GC samples compared with GU and the fold decrease valued 2.2 fold for miR-204 and 1.8 folds for miR-182. On the other hand, the significant escalation in the level of lnRNA H19 in GU recorded a 16.8 fold increase and further elevation in its levels was evident in GC samples. No 30945348 H19 LncRNA Homo sapiens Polycystic Ovary Syndrome blood Expression[highly expressed] qRT-PCR The expression of lncRNA H19 was significantly higher in cases of PCOS than in controls. No 30982795 H19 LncRNA Homo sapiens Heart Neoplasms cardiac cancer tissues Expression[highly expressed] Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay The study results indicated that H19, miR-130a-3p, and miR-17-5p expressions within cardiac cancer tissues were significantly beyond those within adjacent nontumor tissues (P < 0.05), and H19 expression was positively correlated with both miR-130a-3p (rs = 0.43) and miR-17-5p (rs = 0.49) expressions. No 30843379 H19 LncRNA Homo sapiens Cerebral Hemorrhage brain tissues Expression[highly expressed] qRT-PCR//Microarray NR_027324, or H19, was the most upregulated lncRNA after 1 day from the two ICH models and its elevation persisted until the 7th day. No 31557399 H19 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation(Wnt/β-catenin regulatory axis) In Vivo Experiment//qRT-PCR//Luciferase Report Assay//IF It is known that the long non-coding RNA H19, which is frequently elevated in HCC, plays a vital role in mediating tumorigenesis and cancer progression. Our results demonstrated that H19 was down-regulated by API, and thereby induced the inactivation of the canonical Wnt/β-catenin signaling. No 33345859 H19 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Regulation[miR-193b/MAPK1 axis] qRT-PCR We mined gene expression profiles of 457 HCC samples from TCGA and TJMUCH cohorts and further validated in 64 FFPE HCC tissues. LncRNA H19 overexpression in situ was significantly correlated with poor prognosis of HCC patients, which induced EMT, promoted stemness and accelerated invasion of HCC cells in vitro.Co-expression network analysis indicated lncRNA H19 negatively correlated with miR-193b and positively correlated with MAPK1 gene, which implicated that lncRNA H19 served as a sponge molecule to hijack miR-193b and protect MAPK1. Forced overexpression of H19 attenuated miR-193b-mediated inhibition on multiple driver oncogenes (EGFR, KRAS, PTEN and IGF1R) and MAPK1 gene, thus triggered EMT and stem cell transformation in HCC. LncRNA H19 positively correlated with CD68 TAMs in situ. TAMs-induced lncRNA H19 promotes HCC aggressiveness via triggering and activating the miR-193b/MAPK1 axis, mediates the crosstalk between HCC and immunological microenvironment, and causes poor clinical outcomes. LncRNA H19 is a valuable predictive biomarker and potential therapeutic target in HCC. + No 31705929 H19 LncRNA Homo sapiens Nasopharyngeal Neoplasms cell lines Expression[highly expressed] qRT-PCR The expression of H19 and miR-675-5p are significantly higher in NPC cells than in NP69 cell (P<0.05). No 31677258 H19 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Mutation[rs2839698/rs3741219 ] Genotyping In this study, the link of H19 gene polymorphisms to hepatocarcinogenesis was assessed between 359 HCC patients and 1190 cancer-free subjects. We found that heterozygotes for the minor allele of H19 rs2839698 (T) and rs3741219 (G) were more inclined to develop HCC (OR, 1.291; 95% CI, 1.003-1.661; p = 0.047, and OR, 1.361; 95% CI, 1.054-1.758; p = 0.018, respectively), whereas homozygotes for the polymorphic allele of rs2107425 (TT) were correlated with a decreased risk of HCC (OR, 0.606; 95% CI, 0.410-0.895; p = 0.012). Moreover, patients who bear at least one variant allele (heterozygote or homozygote) of rs3024270 were less prone to develop late-stage tumors (for stage III/IV; OR, 0.566; 95% CI, 0.342-0.937; p = 0.027). In addition, carriers of a particular haplotype of three H19 SNPs tested were more susceptible to HCC. In conclusion, our results indicate an association between H19 gene polymorphisms and the incidence and progression of liver cancer. In this study, the link of H19 gene polymorphisms to hepatocarcinogenesis was assessed between 359 HCC patients and 1190 cancer-free subjects. We found that heterozygotes for the minor allele of H19 rs2839698 (T) and rs3741219 (G) were more inclined to develop HCC (OR, 1.291; 95% CI, 1.003-1.661; p = 0.047, and OR, 1.361; 95% CI, 1.054-1.758; p = 0.018, respectively), whereas homozygotes for the polymorphic allele of rs2107425 (TT) were correlated with a decreased risk of HCC (OR, 0.606; 95% CI, 0.410-0.895; p = 0.012). Moreover, patients who bear at least one variant allele (heterozygote or homozygote) of rs3024270 were less prone to develop late-stage tumors (for stage III/IV; OR, 0.566; 95% CI, 0.342-0.937; p = 0.027). In addition, carriers of a particular haplotype of three H19 SNPs tested were more susceptible to HCC. In conclusion, our results indicate an association between H19 gene polymorphisms and the incidence and progression of liver cancer. No 31277475 HAR1A LncRNA Homo sapiens Sclerosis peripheral blood cells Expression(lower expressed) qRT-PCR A significant decrease was detected in HAR1A expressions (P < 0.0001), and a moderate increase was also shown in HAR1B of SPMS patients (P value = 0.0189). HAR1A showed different expression levels in patients over forty (P value = 0.034). The expression levels of HAR1A and HAR1B were positively correlated in MS patients (r = 0.2003, P value = 0.0457). In addition, ROC curve results suggested that HAR1A can be introduced as a novel biomarker for MS diagnosis (AUC = 0.776). No 36583781 HAND2-AS1-203 LncRNA Homo sapiens Adrenocortical Carcinoma ACC tissues Expression[lower expressed] qRT-PCR//Microarray In these samples, 874 lncRNAs were differentially expressed in ACC compared with NAC, of which 409 were upregulated, and 465 were downregulated. The 874 differentially expressed lncRNAs corresponded to 330 annotated lncRNA genes. Among the upregulated lncRNAs, the greatest log2 fold change was 8.5 for an unannotated lncRNA gene, and RAD50 was the geratest upregulated, annotated lncRNA gene with a log2 fold change of 6.1. Among the downregulated lncRNAs, the greatest log2 fold change was 8.3 for an unannotated lncRNA gene and 6.4 for HAND2, the greatest downregulated annotated lncRNA gene; of these, 183 differently expressed lncRNAs had established functions in cancer development and cancer progression. Selected carcinogenesis-related lncRNAs are summarized in Table 2. No 31522749 HAND2‐AS1 LncRNA Homo sapiens Colonic Neoplasms COAD tissues Expression[lower expressed] qRT-PCR "To manifest the expression of integrated analysis, we selected the previously obtained eight biomarkers including XXbac‐ B476C20.9, PP7080, CDKN2B‐AS1, LINC00092, CA3‐AS1, HAND2‐AS1, CTD‐2269F5.1, and LINC01082. In Figure 8, these eight selected DElncRNAs for qRT‐PCR confirmation were eight optimal diagnostic lncRNA biomarkers, and these eight DElncRNAs were all downregulated in the high‐ throughput transcriptome datasets for COAD compared with normal controls. The expression of these selected eight genes in qRT‐PCR was consistent with our integrated analysis." No 30269368 HAND2-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular Liver tissues,Liver cancer stem cells Regulation[BMP signaling] FISH//IHC//RNA Pull-Down//Microarray We examined its level in a cohort of 50 liver tumor and paired peri‐tumor tissues and eight normal tissues (Appendix Table S1). HAND2‐AS1 was highly expressed in liver tumors, whereas it was nearly undetectable in normal liver tissues by qRT–PCR analysis (Appendix Fig S1D and Table S2). Its high expression was verified in liver cancer tissues by in situ hybridization (Fig 1B). Furthermore, HAND2‐AS1 showed high expression in oncosphere cells (Appendix Fig S1E). Here, we identified a long noncoding RNA (lncRNA) termed HAND2-AS1 that is highly expressed in liver CSCs. Mechanistically, HAND2-AS1 recruits the INO80 chromatin-remodeling complex to the promoter of BMPR1A, thereby inducing its expression and leading to the activation of BMP signaling. Importantly, interfering with expression of HAND2-AS1 by antisense oligonucleotides (ASOs) and BMPR1A by siRNAs has synergistic anti-tumorigenic effects on humanized HCC models. Moreover, knockout of lncHand2 or Bmpr1a in mouse hepatocytes impairs BMP signaling and suppresses the initiation of liver cancer. Our findings reveal that HAND2-AS1 promotes the self-renewal of liver CSCs and drives liver oncogenesis, offering a potential new target for HCC therapy. No 31334575 HAND2-AS1 LncRNA Homo sapiens ovarian carcinoma cell line Expression[lower expressed] qRT-PCR From RNA-sequencing analysis performed between an OC cell line, SKOV3, and a Fallopian Tube (FT) cell line, FT194, an important long non-coding RNA, HAND2 Anti sense RNA 1 (HAND2-AS1), was observed to be significantly downregulated in OCs when compared to FT. No 32517089 HAND2-AS1 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[lower expressed] qRT-PCR Plasma levels of IGF-1 and lncRNA HAND2-AS1 were significantly lower in end-stage DCM patients than in healthy controls, and were only positively correlated in end-stage DCM patients. A follow-up study revealed that low levels of IGF-1 or lncRNA HAND2-AS1 were significantly associated with poor survival. In the human cardiomyocyte cell line AC16, lncRNA HAND2-AS1 overexpression failed to alter IGF-1 levels and IGF-1 overexpression did not affect lncRNA HAND2-AS1 expression. No 31248315 HAND2-AS1 LncRNA Homo sapiens Leukemia, Myelogenous, Chronic, BCR-ABL Positive Bone marrow Interaction[sponging with micRNA-1275] qRT-PCR//MTT//Luciferase Report Assay//Western Blot Results showed that HAND2-AS1 was significantly downregulated than healthy control (p<0.05), and HAND2-AS1 expressions on stages of AP and BP were much lower than that of CP (p<0.05).HAND2-AS1 was downregulated and miR-1275 was upregulated in CML, and HAND2-AS1 inhibited proliferation and promoted apoptosis of CML cells by sponging with microRNA-1275, which might be a novel therapeutic target for CML. No 30915755 HAM-1 LncRNA Homo sapiens Thyroid Carcinoma, Anaplastic Anaplastic Thyroid Carcinomas tissues Expression[highly expressed] qRT-PCR//Microarray Two of the upregulated lncRNAs, PCA3 and HAM-1, were analyzed on a thyroid carcinoma TMA. There was increased expression of both lncRNAs in ATCs and PTCs compared with NT after TMA analysis. qRT-PCR analyses showed increased expression of both lncRNAs in ATCs compared with NT and PTCs No 31468286 HAGLROS LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Interaction[ miR-100] qRT-PCR HAGLROS was significantly upregulated in ovarian cancer (P < 0.001) and was closely related to disease stage (P = 0.033), tumour size (P = 0.032) and poor prognosis (P = 0.019). It can be used as a molecular sponge of miR-100 to regulate the expression of mTOR and ZNRF2 and affect the signal transduction of the mTOR pathway. HAGLROS was significantly upregulated in ovarian cancer (P < 0.001) and was closely related to disease stage (P = 0.033), tumour size (P = 0.032) and poor prognosis (P = 0.019). No 31197441 HAGLR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,Blood Expression[lower expressed] qRT-PCR we observed that lower HAGLR expression level in NSCLC patients than adjacent normal tissues No 35116979 HAGLR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 H675 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissue Interaction[miR-675-5p] qRT-PCR//MTT//Luciferase Report Assay//Western Blot In NSCLC patients with COPD, H19 and miR-675 levels were strikingly upregulated while P53 level was significantly downregulated.P53 was identified as a target gene of miR-675, and H19 remarkably upregulated miR-675, while H19 siRNA notably inhibited miR-675. In addition, miR-675 and H19 dramatically suppressed the expression of P53 and Bax while inducing the expression of Bcl-2. Finally, H19 and miR-675 induced proliferation of A549 and MRC-5 cells. No 31219199 H2BC20P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 H2AJ LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 H19 LncRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR Our results showed that the H19 level was significantly (P = 0.008) elevated and MEG3 expression was significantly (P = 0.002) down-regulated in GC patients compared to healthy participants. No 30447342 H19 LncRNA Homo sapiens Stomach Neoplasms GC tissue Expression[highly expressed] CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay Meanwhile, the level of HOTAIR, H19, PVT1, and LINC00152 was upregulated. No 32951010 H19 LncRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR showed that the H19 level was significantly elevated while miR-139 and miR-200c expression were significantly down-regulated in GC patients, compared to GU participants (P < 0.01). No 32795593 H19 LncRNA Homo sapiens Stomach Neoplasms 150 GC patients and 100 healthy controls Epigenetics(hypermethylated ) Bioinformatics Analysis H19 gene, H19C island, and MALAT1B island, as well as 20 CpG sites were hypermethylated in peripheral blood of GC patients compared with HCs; similar results were also found in female and male groups (P < .05 for all). The combination of H19c3, H19c4, MALAT1b12, and age, as well as the combination of H19b7, H19c1, H19c5, and age in the nomograms could distinguish GC patients from HCs in the female group and male group, respectively. No 34615385 H19 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Mutation[rs2839698;rs217727] Genotyping The T allele of rs2839698 conferred breast cancer risk in the assessed population (OR (95% CI) = 2.52 (1.75-3.64), adjusted P value = 1.3E-6), while and the T allele of rs217727 had a protective effect (OR (95% CI) = 0.42 (0.27-0.66), adjusted P value = 2.8E-4). Both SNPs were associated with breast cancer risk in recessive, dominant and co-dominant models. The T C haplotype (rs2839698 and rs217727) significantly increased risk of breast cancer (OR (95% CI) = 2.4 (1.65-3.45), adjusted P value = 1.2E-5), while the C T haplotype had a protective role (OR (95% CI) = 0.31 (0.18-0.52), adjusted P value = 2.03E-5). No 30910558 H19 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Mutation[ rs217727 C>T] qRT-PCR In addition, our findings revealed a significant differences in allele frequencies in lncRNA-H19 rs217727 C>T polymorphism between groups (P = 0.033; OR = 1.985; 95% CI, 1.048-3.761). Our findings suggested that rs217727 C>T polymorphism may be involved in the pathogenesis of BC. No 30485527 H19 LncRNA Homo sapiens Breast Neoplasms blood Interaction[H19/miR-675] qRT-PCR We quantified each RNA in plasma samples of 63 BC patients and 10 healthy women by quantitative real-time PCR. In cell culture experiments, the influence of these noncoding RNAs (ncRNAs) on proliferation and apoptosis of BC cell line MCF-7 was examined. Plasma levels of H19 (P = 0.030), NEAT1 (P = 0.030), and miR-331 (P = 0.012) were deregulated in BC patients compared with healthy women. In both cohorts, the concentrations of H19 correlated with those of miR-675 (P = 0.0001). Higher H19 (P = 0.001) along with lower miR-675 (P = 0.007) levels and higher miR-204 (P = 0.017) along with lower NEAT1 (P = 0.030) levels were detected in plasma of HER2-positive patients compared with the other BC subgroups. Whereas the expression of HOTAIR was below the detection level, miR-331 levels correlated with nodal status (P = 0.002) and recurrence (P = 0.012). In cell culture experiments, a competitive impact on cell proliferation and apoptosis by these ncRNAs was also documented. Our findings describe a relationship of the plasma levels of H19/miR-675 and NEAT1/miR-204 in the different BC subtypes; in addition, they reveal an interplay between these lncRNAs and miRNAs in the regulatory network in MCF-7 cells, which should also be considered in the search for new diagnostic and therapeutic markers. No 30803129 H19 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[FOXF2 ] qRT-PCR//ChIP FOXF2 and H19 were upregulated in NSCLC and a positive correlation was observed between the two genes.FOXF2 could bind to the promoter region of H19 and accelerated its transcription. Moreover, H19 could recruit EZH2 to bind to PTEN. The overexpression of H19 could reverse the regulatory effects of FOXF2 on the viability and migration of A549 cells. No 31858547 H19 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung blood Mutation[rs2067051] Genotyping rs2067051 was associated with a significantly decreased risk of NSCLC in our population [AA vs. GG: adjusted odds ratio (OR) = 0.75, 95% confidence interval (CI)=0.60-0.93; Additive model: OR=0.79, 95%CI=0.67-0.93)]. rs217727 was related to significantly increased NSCLC susceptibility (TT vs. CC: OR=1.16, 95%CI=1.01-1.33; Additive model: OR=1.16, 95%CI=1.01-1.33). No 31424642 H19 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 H19 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and adjacent tissues Expression[highly expressed] qRT-PCR The results showed that H19 and MALAT1 was significantly higher expression in CRC tissues than in the adjacent normal colorectal mucosa No 31232113 H19 LncRNA Homo sapiens Colorectal Neoplasms blood Mutation[rs4930101/rs11042170/rs27359703 ] Genotyping 3 SNPs of rs4930101, rs11042170, and rs27359703 among 16 identified SNPs of H19 gene remarkably increased CRC risk. No 31452627 H19 LncRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR The expression of HOTAIR and H19 showed 7.55- and 11.38-fold increased levels, respectively, in CRC patients compared to the controls (p < 0.001). No 31433231 H19 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Expression[highly expressed] qRT-PCR//Wound Healing Assay//Transwell Assay//Western Blot lncRNA H19 expression was 2.417-fold higher in PTC tissues than their paired paracancerous tissue (95% CI: 1.898-2.935, P<0.0001). No 30881130 H19 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR Compared with adjacent normal tissues, the H19 expression level was higher and MAPK and ERK protein levels were lower in HCC tissues. No 29800569 H19 LncRNA Homo sapiens Corneal Neovascularization cell line (HUVECs) Interaction[targeting microRNA-29c] CCK8//qRT-PCR//Wound Healing Assay//Western Blot Here, we found that the H19 levels were remarkably increased in vascularized corneas and basic fibroblast growth factor (bFGF)-treated human umbilical vein endothelial cells (HUVECs).In vitro, H19 up-regulation promoted proliferation, migration, tube formation and vascular endothelial growth factor A (VEGFA) expression in HUVECs, and it was found to down-regulate microRNA-29c (miR-29c) expression. Bioinformatics analysis revealed that H19 mediated the above effects by binding directly to miR-29c. In addition, miR-29c expression was markedly reduced in vascularized corneas and its expression also decreased in bFGF-treated HUVECs in vitro MiR-29c targeted the 3' untranslated region (3'-UTR) of VEGFA and decreased its expression. No 30948500 H19 LncRNA Homo sapiens Diabetes Mellitus blood Interaction[AKT/eNOS signal pathway ] RIP//qRT-PCR//Luciferase Report Assay//Western Blot We demonstrate that H19 is upregulated and miR-29b downregulated in individuals with DM and directly binds miR-29b. We conclude that H19 suppression protects the endothelium against high glucose-induced inflammation and oxidative stress in endothelial cells by upregulation of miR-29b and downregulation of VEGFA through AKT/eNOS signal pathway activation. These results suggest a novel link between dysregulated ncRNA expression, inflammation, and the signaling pathway in the vascular endothelium of individuals with DM, indicating a promising strategy for preventing cardiovascular disease in such individuals. No 31737629 HAR1A LncRNA Homo sapiens Carcinoma, Hepatocellular Liver tissues Expression[lower expressed] qRT-PCR NEAT1 was overexpressed in all three sorafenib and doxorubicin resistant cell lines. No 30304523 GVQW3-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 GUSBP11-201 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 GUSBP11 LncRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] Microarray A two-stage validation revealed that plasma levels of three lncRNAs (FAM49B-AS, GUSBP11, and CTDHUT) were significantly higher in GC plasma as compared with healthy controls (P < 0.05), and the combined area under curve of these lncRNAs was 0.818 (95% CI 0.772-0.864). No 30603909 GUCY2EP LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 GTF3C2-AS1-205 LncRNA Homo sapiens Diabetes Mellitus, Type 2 blood Expression[lower expressed] qRT-PCR//Microarray Compared with the control group, the expression levels of the GCKR gene and lncRNA ENST00000588707.1 and TCONS_00004187 in the T2DM group were significantly lower (P < 0.05). The correlation analysis revealed that ENST00000588707.1 and TCONS_00004187 were correlated with GCKR gene expression and glycolipid metabolism (P < 0.05). ROC analysis showed that the area under the curve value of ENST00000588707.1 between T2DM patients and non-T2DM patients was 0.816 (95% CI: 0.764-0.869, sensitivity 72.0%, specificity 80.3%) and the AUC value of TCONS_00004187 was 0.826 (95% CI: 0.774-0.879, sensitivity 81.6%, specificity 61.3%). No 31756311 GTF3C2-AS1 LncRNA Homo sapiens Endometrial Neoplasms 301 UCEC patients Regulation Bioinformatics Analysis We detected a novel lncRNA-focus expression signature (LFES) consisting of 11 lncRNAs that were associated with survival based on risk scoring strategy in UCEC. The risk score based on the LFES was able to separate patients of discovery cohort into high-risk and low-risk groups with significantly different overall survival and progression-free survival, and has been successfully confirmed in the validation cohort. No 29304762 GSTM3TV2 LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues Expression[highly expressed] qRT-PCR Comparing toadjacent tissues(0.084±0.019), GSTM3TV2 expression was significantly upregulated in the pancreatic cancer tissues(0.493±0.084) (t=5.146, P<0.05). No 31474062 GSS-225 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 GSN.AS1 LncRNA Homo sapiens Breast Neoplasms TCGA(1,104 tumor samples and 292 normal samples) Regulation Bioinformatics Analysis In total, five metabolism-related lncRNAs were enrolled to establish prognostic signatures. Further analysis demonstrated that the signature was an independent prognostic factor for BC. No 34254565 GSK3A CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 GSEC LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction(miRNA-101-3p/CISD1 Axis ) Cell Proliferation Assay//qRT-PCR//IHC//migration assay We also found GSEC, CISD1, ATP5MC3, and PGD to be upregulated, with miRNA-101-3p downregulated, in the setting of LUAD. In summary, this study characterizes relevant functional roles of the lncRNA GSEC/miR-101-3p axis in the setting of LUAD and suggests diagnostic and therapeutic biomarkers potentially useful in the clinical management of this illness. No 35320929 GSE61474_TCONS_00183926 LncRNA Homo sapiens acral lentiginous melanoma tumor and six adjacent non-tumor tissues Expression[highly expressed] qRT-PCR//Microarray The top 5 upregulated lncRNAs were T380070, ENST00000554431, T097678, GSE61474_TCONS_00183926 and NR_015402. No 31966073 GS1-421I3.2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 GRTP1-AS1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 GRM7-211 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 GRM7-210 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 GRID2 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 GREM1 LncRNA Homo sapiens Diabetes Mellitus, Type 2 Sixty individuals Mutation(rs16969681 ) Genotyping TCF7L2 rs7903146, CASC8 rs6983267 and GREM1 rs16969681 could be risk factors for the association of T2DM with CRC. No 35893034 GRB10 CircRNA Homo sapiens degenerative disc disease 60 cases of LDDD Expression(lower expressed) qPCR//PCR Compared to HCs, decreased accumulation of GRB10 RNA was only observed in LDDD group, but not in SJP, LDH, PS and EN groups. With plasma expression level of GRB10 measured before treatment as a biomarker, LDDD patients were separated from SJP, LDH, PS, EN and HC groups. No 36251122 GRASLND LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 GPS2-213 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 GPR89A-208 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 GPR160-206 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 GPHN CircRNA Homo sapiens Alzheimer Disease cerebrospinal fluid Expression[highly expressed] qRT-PCR//Microarray By RT-qPCR, circ-LPAR1, circ-AXL and circ-GPHN were increased, whereas circ-PCCA, circ-HAUS4, circ-KIF18B and circ-TTC41C were decreased in AD patients compared with Ctrl subjects, and these circRNAs were disclosed to predict AD risk by receiver operating characteristics curve analysis. No 32315771 GPC6-AS2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 GPAM-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 GOLGA8T LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 GOLGA6L5P LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 591 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 GOLGA2P7 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 GOLGA2P10 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 GVINP1 LncRNA Homo sapiens Adenocarcinoma of Lung Expression[highly expressed] qRT-PCR "The results showed that CEBPA‐AS1 and GVINP1 were downregulated in LUAD tumor tissues, while MIR31HG and RAET1K were upregulated in LUAD tumor tissues (Figure 4). The qRT‐PCR results of these four lncRNAs were consistent with our TCGA bioinformatics results, indicating that our TCGA analysis was credible" No 30125988 GXYLT1P3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 910 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 H19 LncRNA Homo sapiens transitional cell carcinoma blood Mutation[rs217727/rs2107425 ] Genotyping The results showed that patients with UCC carrying the H19 rs217727 CT + TT and rs2107425 CT + TT genetic variants had a high risk of developing muscle invasive tumors (pT2-T4) (p = 0.030; p = 0.025, respectively). With a median follow up of 39 months, CT+TT polymorphisms of rs2107425 were associated with worse disease-specific survival (adjusted hard ratio (AHR) = 2.043, 95% confidence interval (CI) = 1.029-4.059) in UCC patients aged older than 65 years. In conclusion, our results indicate that patients with UCC carrying the H19 rs217727 CT + TT and rs2107425 CT + TT genetic variants have a high risk of developing muscle invasive tumors. Thus, H19 polymorphisms may be applied as a marker or therapeutic target in UCC treatment. No 31013794 GXYLT2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 H19 LncRNA Homo sapiens Adenocarcinoma, Follicular Expression[lower expressed] qRT-PCR In our study, we used quantitative real-time polymerase chain reaction (qRT-PCR) to determine H19 expression in 186 patients with MI-FTC who underwent initial surgery. Of the 186 patients with MI-FTC, 21 patients show distant metastasis （M+）at the initial operation established the diagnosis of MI-FTC. Of the 165 patients who did not show distant metastasis at diagnosis during the follow-up period (≥10 years), 28 patients undergone M+ and 137 patients has no distant metastasis（M-）after the initial operation. Low H19 expression was associated with large tumor size, vascular invasion, and distant metastasis. Univariate analysis showed that gender (male), age (45 years or older), primary tumor size (4 cm or more), vascular invasion and H19 level (<1.12) were significant prognostic factors related to postoperative distant metastases. Multivariate analysis showed that age, primary tumor size (4 cm or more) and vascular invasion was a significant prognostic factor for survival. Patients with low H19 expression showed a poorer outcome in MI-FTC patients. Receiver-operating characteristic (ROC) curve analysis demonstrated H19 could distinguish M+ from M- patientswith a value of area under the curve (AUC). Our findings suggest that H19 is a potential prognostic factor for evaluating prognosis and the metastatic potential of MI-FTC at an initial operation stage. In our study, we used quantitative real-time polymerase chain reaction (qRT-PCR) to determine H19 expression in 186 patients with MI-FTC who underwent initial surgery. Of the 186 patients with MI-FTC, 21 patients show distant metastasis （M+）at the initial operation established the diagnosis of MI-FTC. Of the 165 patients who did not show distant metastasis at diagnosis during the follow-up period (≥10 years), 28 patients undergone M+ and 137 patients has no distant metastasis（M-）after the initial operation. Low H19 expression was associated with large tumor size, vascular invasion, and distant metastasis. Univariate analysis showed that gender (male), age (45 years or older), primary tumor size (4 cm or more), vascular invasion and H19 level (<1.12) were significant prognostic factors related to postoperative distant metastases. Multivariate analysis showed that age, primary tumor size (4 cm or more) and vascular invasion was a significant prognostic factor for survival. Patients with low H19 expression showed a poorer outcome in MI-FTC patients. Receiver-operating characteristic (ROC) curve analysis demonstrated H19 could distinguish M+ from M- patientswith a value of area under the curve (AUC). Our findings suggest that H19 is a potential prognostic factor for evaluating prognosis and the metastatic potential of MI-FTC at an initial operation stage. No 31791180 H19 LncRNA Homo sapiens Leiomyoma myometrial tissues Expression[highly expressed] CCK8//qRT-PCR Here we report that the expression of H19 long noncoding RNA (lncRNA) is aberrantly increased in UFs.Using cell culture and genome-wide transcriptome and methylation profiling analyses, we demonstrate that H19 promotes expression of MED12, HMGA2, and key ECM-remodeling genes via multiple mechanisms including a new class of epigenetic modification by TET3. Our results mark the first example of an evolutionarily conserved lncRNA in pathogenesis of UFs and regulation of TET expression. Given the link between a H19 single-nucleotide polymorphism (SNP) and increased risk and tumor size of UFs, and the existence of multiple fibroid subtypes driven by key pathway genes regulated by H19, we propose a unifying mechanism for pathogenesis of uterine fibroids mediated by H19 and identify a pathway for future exploration of novel target therapies for uterine leiomyomas. No 31089260 H19 LncRNA Homo sapiens Non-alcoholic Fatty Liver Disease liver tissues,cell lines Regulation[miR-130a/PPARγ axis] RNA Pull-Down//Western Blot//qRT-PCR//Luciferase Report Assay//Oil Red O Staining//ELISA//IHC H19 and PPARγ were up-regulated, while miR-130a was down-regulated in NAFLD mouse and cellular model.Knockdown of H19 inhibited steatosis and TG secretion in FFA-induced hepatocytes. H19 could bind to miR-130a, and miR-130a could directly inhibit PPARγ expression. Meanwhile, miR-130a inhibited lipid accumulation by down-regulating NAFLD-related genes PPARγ, SREBP1, SCD1, ACC1 and FASN. Overexpression of miR-130a and PPARγ antagonist GW9662 inhibited lipogenesis and TG secretion, and PPARγ agonist GW1929 reversed this change induced by miR-130a up-regulation. No 31064820 H19 LncRNA Homo sapiens Ischemic Stroke blood Interaction[p53/Notch1 pathway] qRT-PCR//Western Blot//IF It was demonstrated that the levels of plasma H19 were significantly higher than that of the healthy controls (Fig. 1A; P < 0.0001). Our findings demonstrate that H19 prevents the process of neurogenesis after ischemic stroke through p53/Notch1 pathway and strengthen the novel role of H19-based therapy for ischemic stroke. No 31102753 H19 LncRNA Homo sapiens Ischemic Stroke Blood samples were collected from IS patients (n = 114) and controls (n = 114). Mutation(rs217727 ) Genotyping The rs217727polymorphism of H19 was related with IS susceptibility in the co-dominant (OR = 2.92, 95% CI = 0.91-10.92, P = 0.04) and recessive models (OR = 2.80, 95% CI = 0.96-8.15, P = 0.04). H19 expression was significantly upregulated in IS and remained high for 72 h after stroke. No 33541284 H19 LncRNA Homo sapiens Ischemic Stroke leukocytes of patients with stroke Interaction(miR-29b/C1QTNF6 axis) Western Blot//Transfection//Tunel//Flow Cytometry//qRT-PCR//ELISA//IF H19 and C1QTNF6 upregulation, as well as miR-29b downregulation, was detected in leukocytes of patients with stroke. Moreover, miR-29b could bind C1QTNF6 mRNA and repress its expression, while H19 could sponge miR-29b to maintain C1QTNF6 expression. No 35322553 H19 LncRNA Homo sapiens gastric adenocarcinoma GA tissues Expression[differently expression] qRT-PCR//Microarray The expression of 5 differentially expressed lncRNAs, HNF1A-AS1, RP11-62F24.2, GAS5, MALAT1, and H19 were randomly selected to be measured in 47 patients using real-time quantitative reverse transcription PCR (qRT-PCR), and the data were consistent with those obtained from the microarray chip. No 31850717 H19 LncRNA Homo sapiens Myelodysplastic Syndromes bone marrow Expression[highly expressed] qRT-PCR//Microarray Of the functionally described lncRNAs, we detected the upregulation of H19, EMCN-IT1, WT1-AS, MEG8, and PVT1 and the downregulation of ST6GAL2-IT1 and U3. No 32977510 H19 LncRNA Homo sapiens Pulmonary Arterial Hypertension blood Expression[highly expressed] qRT-PCR We demonstrated that H19 is upregulated in decompensated RV from PAH patients and correlates with RV hypertrophy and fibrosis. No 32698630 H19 LncRNA Homo sapiens Nephrotic Syndrome blood regulation[Inhibiting ADCK4 Signal] qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP Long noncoding RNA H19 (lncRNA H19) expression was downregulated in PBMCs of children with nephrotic syndrome. Furthermore, our study demonstrated that H19 could regulate the promoter activity of ADCK4. No 32489187 H19 LncRNA Homo sapiens Breast Diseases Exosomal Expression[highly expressed] qRT-PCR Exosomal H19 expression levels were upregulated in patients with BC compared to that in patients with BBD and healthy controls (BC vs BBD, P < 0.001; BC vs healthy subjects, P < 0.001). No 32273726 H19 LncRNA Homo sapiens Colonic Neoplasms Colon Cancer tissue Expression [highly expressed] Bioinformatics Analysis Colon cancer H19 expression is associated with advanced stage of tumor disease and is a significant risk factor for reduced recurrence-free survival.  No 34520983 H19 LncRNA Homo sapiens Colorectal Cancer Patients With Type 2 Diabetes CRC tissues Expression [highly expressed] qRT-PCR The results showed that H19 and MALAT1 expression were higher in CRC tissues than in normal colorectal mucosa (p = 1.59 × 10-6 and p = 6.95 × 10-9, respectively), whereas lincRNA-p21 showed lower expression in CRC tissues (p = 1.10 × 10-4). No 31232113 H19 LncRNA Homo sapiens Acute Lung Injury PMVEC Interaction(miR-107/TGFBR3 axis) In Vivo Experiment//Western Blot//Transfection//Tunel//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//H&E Staining//ELISA H19 was poorly-expressed in CLP-operated mice. H19 overexpression attenuated sepsis-induced ALI, which was manifested with complete alveolar structure, decreased lung injury score and lung W/D ratio, and inhibited apoptosis in CLP-operated mice, which was manifested with decreased number of TUNEL-positive cells and Bax level and increased Bcl-2 level. CLP-operated mice had increased concentration of total protein and number of total cells, neutrophils, and macrophages in BALF, which was nullified by H19 overexpression. H19 overexpression declined levels of TNF-α, IL-1β, and IL-6 and elevated IL-10 levels. H19 inhibited LPS-induced PMVEC apoptosis and pro-inflammatory cytokine production. H19 targeted TGFBR3 as the ceRNA of miR-107. miR-107 overexpression or silencing TGFBR3 partially averted the inhibition of H19 overexpression on LPS-induced PMVEC apoptosis and pro-inflammatory cytokine production. No 36180862 H19 LncRNA Homo sapiens Renal Insufficiency, Chronic serum from 56 CKD patients and 20 healthy controls Expression [highly expressed] qRT-PCR//ELISA We found that lncRNA H19 expressions were upregulated in patients with CKD compared to the controls. Furthermore, lncRNA H19 relative expression levels showed a negative relationship with glomerular filtration rate (GFR) while it was positively correlated with ferritin, phosphorus, parathyroid hormone, TNF-α, IL-6, OC, TAS and TOS levels. No 33548016 H19 LncRNA Homo sapiens Laryngeal Neoplasms neoplastic vs paired non-neoplastic samples Expression(highly expressed) qRT-PCR Higher H19 relative expression in neoplastic vs paired non-neoplastic samples was found (p < 0.0001) with a significant increase in EBV DNA positive neoplasms (p = 0.0434). No 34825669 H19 LncRNA Homo sapiens childhood leukemia Two hundred and sixty-six childhood leukemia patients and 266 healthy controls in Taiwan Mutation(rs2839698 ) qRT-PCR//Genotyping Interestingly, the average level of H19 rs2839698 was statistically significantly higher for patients with CT and TT genotypes than from those with the CC genotype (p < 0.0001). No 33800276 H19 LncRNA Homo sapiens Arthritis, Gouty AGA patients and cell line Interaction(miR-2-3p) qRT-PCR//Transfection//ELISA//Luciferase Report Assay Expressions of serum H19 in AGA patients were significantly higher than that in controls. The ROC curve indicated the potential of H19 as a diagnostic marker for AGA. Cell experiments revealed that the downregulation of H19 significantly inhibited the expressions of IL-1β, IL-8, and TNF-α. The luciferase reporter gene assay manifested that miR-22-3p is the target gene of H19. And knockdown of miR-22-3p overturned the downregulation of inflammatory factors caused by H19 inhibition. H19 aggravated MSU-induced THP-1 inflammation by negatively targeting miR-22-3p, suggesting a new regulatory mechanism and potential therapeutic target for AGA. No 35314952 H19 LncRNA Homo sapiens Muscular Dystrophy, Facioscapulohumeral FSHD cells Regulation(DUX4) Northern Blot//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay Human miR-675 inhibits DUX4 expression and associated outcomes in FSHD cell models. In addition, miR-675 delivery using gene therapy protects muscles from DUX4-associated death in mice. Finally, we show that three known miR-675-upregulating small molecules inhibit DUX4 and DUX4-activated FSHD biomarkers in FSHD patient-derived myotubes. No 34880230 H19 LncRNA Homo sapiens Colorectal Neoplasms Tumor and tumor-free surrounding tissue samples were obtained from 51 CRC cases Expression(highly expressed) qRT-PCR Expression of H19 in tumor tissue was found to be 2.11 times higher than that of tumor-free surrounding tissue (p<0.001). No 35220220 H19 LncRNA Homo sapiens Cholangiocarcinoma carcinoma tissue Expression(lower expressed) qRT-PCR Specifically,CASC2 had higher expression level in the carcinoma tissue than in the para-carcinoma tissue(t=1.262,P=0.025),whereas the expression of H19 showed an opposite trend(t=1.285,P=0.005).The expression levels of H19 were significantly lower in RBE(t=-10.244,P<0.001),QBC939(t=-10.476,P<0.001),HuH-28(t=-19.798,P<0.001),and HuCCT1(t=-16.193,P=0.004)cells than in the control group. No 35300768 H19 LncRNA Homo sapiens Glomerulonephritis, IGA 204 patients with IgAN Expression(lower expressed) qPCR H19 expression was significantly downregulated in patients with IgAN compared to healthy controls. Restricted cubic spline analyses showed that the relationship was negatively and linearly correlated (P for nonlinearly = 0.256). After adjusting for other potential clinical, pathologic, and treatment factors, H19 was found to be a protective factor for prognosis in IgAN (HR, 0.52; 95% CI 0.32-0.84; P = 0.008). ROC curve analysis showed that the clinical value of lncRNA H19 with CKD and area under the ROC curve was 0.746 (95% CI 0.663-0.829; P < 0.001) of the clinical prognostic value of H19. No 36574208 H19 LncRNA Homo sapiens Irritable Bowel Syndrome 42 diabetic patients, 42 diabetic patients with IBS, and 42 healthy controls Expression(lower expressed) qRT-PCR H19 and TUG1 were downregulated in patients with poor glycemic control. Diabetic patients with IBS had significantly lower levels of lncRNA H19 and TUG1 expression than healthy controls and diabetic-only patients. H19 and TUG1 were downregulated in patients with poor glycemic control. lncRNA H19 and TUG1 expression in diabetic patients with IBS significantly negatively correlated with the IBS severity scoring system. Both lncRNAs’ expression significantly predicted the disease severity. No 36428545 H19 LncRNA Homo sapiens diabetic encephalopathy DE rats, HT-22 cells Interaction(H19/miR-15b/BACE1 axis) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//ELISA//IF MiR-15b was downregulated while H19 and BACE1 were upregulated in the hippocampus CA3 regionof DE rats and AGEs-treated HT-22 cells. No 35961529 H19 LncRNA Homo sapiens Growth Hormone-Secreting Pituitary Adenoma Expression [highly expressed] qRT-PCR Our results revealed that the expression of lncRNA H19 was remarkably higher in invasive GHPAs, however, there was no significant differences between the expression of lncRNA MALAT-1 in invasive GHPAs and non-invasive GHPAs, suggesting that lncRNA H19 may play an important role in GHPA invasion. LncRNA H19 might be a target for the study of GHPAs invasion, and a potential index for the diagnosis or prognosis of GHPAs. No 29604339 H19 LncRNA Mus musculus Colitis, Ulcerative ulcerative colitis mouse model Interaction(miR-141/ICAM-1 and miR-139/CXCR4) In Vivo Experiment//Western Blot//qRT-PCR//MTT//Luciferase Report Assay//cell invasion assay//Transwell Assay The activity of H19 was strongly decreased in cells c-transfected with miR-141/miR-139 and WT H19. In summary, the overexpression of H19 in MSC downregulated miR-139 and miR-141, thus increasing the activity of their targets ICAM-1 and CXCR4, respectively, to exhibit therapeutic effects in ulcerative colitis. No 34630738 H19 LncRNA Mus musculus Neuralgia lumbar fifth dorsal root ganglion Regulation[up-regulated] qRT-PCR//Microarray H19 lncRNA was greatly increased in the L5 dorsal root ganglion at day 14 after SNL and was significantly higher at and after day 4. No 31061251 H19 LncRNA Mus musculus Bronchopulmonary Dysplasia lung tissues regulation[MAPK Signaling Pathway] qRT-PCR//Luciferase Report Assay Subsequently, we found the lncRNA H19 expression level was significantly increased in BPD compared with normal lung tissues using quantitative real-time polymerase chain reaction.Thus, our study validates that lncRNA H19 contributes to the progression of BPD by regulating MAPK signaling pathway, which could be used as a potential target for treating BPD. No 32308025 H19 LncRNA Rattus norvegicus Coronary Restenosis curcumin Regulation(Wnt/β-catenin pathway) Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//H&E Staining//Colony Formation Assay//EdU Staining//Transwell Assay In the present study, we found that the curcumin remarkably downregulated the expression of lncRNA H19 and thereby inhibited intimal hyperplasia-induced vascular restenosis. Furthermore, the inhibition of the expression of H19 by curcumin resulted in the inactivation of the Wnt/β-catenin signaling. Overall, we show that curcumin suppresses intimal hyperplasia via the H19/Wnt/β-catenin pathway, implying that H19 is a critical molecule in the suppression of intimal hyperplasia after balloon injury by curcumin. No 34487706 HAR1A LncRNA Homo sapiens Mouth Neoplasms oral cancer cells. Regulation qRT-PCR//Transfection//Microarray Our findings suggest that the HAR1A, BRD7, and myosin IIA are tumor suppressors while ALPK1 has oncogene-like property in the nucleus and is involved in inflammation and oral cancer progression. More research for HAR1A activators or ALPK1 inhibitors is required to develop potential therapeutic agents for advanced oral cancer. No 34097087 HAR1B LncRNA Homo sapiens Sclerosis peripheral blood cells Expression(highly expressed) qRT-PCR A significant decrease was detected in HAR1A expressions (P < 0.0001), and a moderate increase was also shown in HAR1B of SPMS patients (P value = 0.0189). HAR1A showed different expression levels in patients over forty (P value = 0.034). The expression levels of HAR1A and HAR1B were positively correlated in MS patients (r = 0.2003, P value = 0.0457). In addition, ROC curve results suggested that HAR1A can be introduced as a novel biomarker for MS diagnosis (AUC = 0.776). No 36583781 GNAS-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues Expression[highly expressed] qRT-PCR//Microarray Interestingly, we found several lncRNAs binding to Hes1 (such as, GNAS-AS1, RP11-89K10.1, and RP11-465L10.10) were up-regulated in CRC tissues showed by the tissue microarray. No 31700895 HOTAIR LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Expression[highly expressed] ISH//IHC Our results show that high HOTAIR expression in tumor tissues is strongly correlated with lymph nodes metastasis (LNM) (p=0.039), as reported also for other tumor types, and has a direct strong association with Androgen Receptor (AR) expression (p= 0.019). Our results show that high HOTAIR expression in tumor tissues is strongly correlated with lymph nodes metastasis (LNM) (p=0.039), as reported also for other tumor types, and has a direct strong association with Androgen Receptor (AR) expression (p= 0.019). No 31205562 HOTAIR LncRNA Homo sapiens Colonic Neoplasms 12 colon adenocarcinoma and paired non-tumor tissue samples Expression(highly expressed) qRT-PCR//Transfection//MTT//Bioinformatics Analysis The increased expression and co-expression trend of HOXC11 and HOTAIR were identified in multiple types of cancer from The Cancer Genome Atlas and the results were validated in 12 colon adenocarcinoma and paired non-tumor tissue samples. The expression of HOXC11 and HOTAIR was found to be associated with poor prognosis in colon adenocarcinoma and kidney renal clear cell carcinoma. No 34630664 HOTAIR LncRNA Homo sapiens Multiple Myeloma cell lines Regulation[NF-κB pathway] qRT-PCR//MTT The myeloma cells were randomly divided into three groups, including: group A (myeloma cell group), group B [HOTAIR-small-interfering RNA (siRNA) group], and group C (HOTAIR negative control group).The expression of HOTAIR in group A, group B, and group C was (2.19 ± 0.33), (1.37 ± 0.25), and (2.51 ± 0.27), respectively. Compared with group A and group C, the expression of HOTAIR was significantly downregulated in group B, in which the cells interfered with siRNAs. No 31799674 HOTAIR LncRNA Homo sapiens Primary Ovarian Insufficiency blood Mutation[ rs4759314, rs920778, rs1899663, and rs7958904] Genotyping Our results suggest that the HOTAIR polymorphisms rs4759314, rs920778, rs1899663, and rs7958904 are involved in POI. No 33358212 HOTAIR LncRNA Homo sapiens Glioma glioma cells Interaction(TNFα/NF-κB signaling) In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC//ChIP HOTAIR activated the expression of proteins involved in NF-κB, TNFα, MAPK and other inflammatory signaling pathways. In addition, HOTAIR induced various proteins containing protein kinase structural domains and promoted the enrichment of proteins and complexes of important inflammatory signaling pathways, such as the TNFα/NF-κB signaling protein complex, the IκB kinase complex, and the IKKA-IKKB complex. No 34887871 HOTAIR LncRNA Homo sapiens Ependymoma spinal Expression[highly expressed] ISH//qRT-PCR There was a significant upregulation of HOTAIR expression in spinal MPE and elevated HOTAIR expressions were further confirmed by RNA ISH on the TMA. No 32940681 HOTAIR LncRNA Homo sapiens Lupus Erythematosus, Discoid 163 SLE patients Mutation(rs10783618) Genotyping We aimed to explore the contribution of HOTAIR (rs10783618), LINC-ROR (rs1942347), and MALAT1 (rs3200401) variants to SLE susceptibility and/or severity in 163 SLE patients and age-/sex-matched controls using real-time TaqMan allelic discrimination PCR. HOTAIR rs10783618*C/C was associated with a 77% increased risk of SLE (OR = 1.77, 95%CI = 1.09?2.87, p = 0.020) under the recessive model. Similarly, MALAT1 rs3200401*T/T carriers were three times more likely to develop SLE (OR = 2.89, 95%CI = 1.42?5.90) under the recessive model. While the rs3200401*T/C genotype was associated with a 49?57% decreased risk of SLE under codominant (OR = 0.51, 95%CI = 0.31?0.82, p < 0.001) and over-dominant (OR = 0.43, 95%CI = 0.27?0.68, p < 0.001) models. LINC-ROR rs1942347*A/A patients were more likely to have a positive family history of SLE. At the same time, HOTAIR rs10783618*C/C was associated with a higher frequency of arthritis (p = 0.001) and the presence of oral ulcers (p = 0.002), while patients carrying rs10783618*T/T genotype were more likely to develop hair loss (p < 0.001), weight loss (p = 0.001), and neurological symptoms (p = 0.003). 163 SLE patients No 35626352 HOTAIR LncRNA Homo sapiens Neuroendocrine Tumors gastrointestinal tract and pancreas Regulation(13 HOX genes) ISH//Immunoblotting//IHC The main purpose of this study was to analyze the expression of the paralogous 13 HOX genes, normally involved in embryogenic development and frequently deregulated in human cancers, and of the HOX regulating lncRNA HOTAIR in GEP-NENs.The expression of HOX genes is gradually lost in the transition from GEP NET G1 to NET/NEC G3 tumors, while HOTAIR expression, inversely correlated with HOX genes expression and weakly expressed in low-grade GEP NENs, becomes aberrant in NET G3 and NEC G3 categories. No 34208964 HOTAIR LncRNA Homo sapiens Abortion, Habitual HOTAIR gene Mutation(rs4759314 A>G, rs920778 T>C, rs1899663 G>T, and rs7958904 G>C) Genotyping In all assays, p < 0.05 was considered significant. HOTAIR polymorphisms rs4759314A>G and rs920778T>C were highly associated with increased risk of RPL, specifically the haplotypes rs4759314A>G/rs1899663G>T (G-T) and rs4759314A>G/rs920778 T>C (G-C). No 36421813 HOTAIR LncRNA Homo sapiens Stroke serum of 181 CVS patients Expression(lower expressed) qRT-PCR When compared to controls, lncHOTAIR was significantly downregulated in all case groups (medians in hypertensive and non-hypertensive patients were 0.13, and 0.34, respectively), with a significantly lower level in the hypertensive group (P = 0.05). No 36439973 HOTAIR LncRNA Homo sapiens Stomach Neoplasms tumor samples Expression(highly expressed) qRT-PCR We observed upregulation of HOTAIR but downregulation of MEG3 in tumor compared to the non-tumor tissues. We also found a significant negative association between their expression levels and H. pylori positive status. However, only the expression level of HOTAIR was significantly associated with the size and stage of the tumor (P < 0.05). The ROC curve analysis revealed that the expression levels of MEG3 and HOTAIR might discriminate GC tumor and non-tumor tissues. No 35186192 HOTAIR LncRNA Homo sapiens RNA, Long Noncoding glioma tissues Interaction(HOXA9) qRT-PCR//ChIP Integrated in silico analyses, chromatin immunoprecipitation, and qPCR data showed that HOXA9 binds directly to the promoter of HOTAIR. High levels of HOTAIR were associated with higher grades of glioma, particularly IDH wild-type cases. No 29644006 Hotair LncRNA Mus musculus Pancreatic Neoplasms Tumor Tissues Activation(Wnt/β-Catenin Signaling Pathway) In Vivo Experiment//Western Blot//CCK8//H&E Staining//Transwell Assay HOTAIR was found to be highly expressed in the PC cells in mice. The expression of β-catenin, cyclinD1, c-myc, LEF-1 and c-Jun, N-cadherin and Vimentin was found to be decreased, while the expression of E-cadherin was found to be increased subsequent to the silencing of HOTAIR in human PC cell lines PANC-1 and Miapaca-2. No 33883938 Hotair LncRNA Mus musculus Leukemia blood Regulation[Wnt/β-catenin signaling pathway ] qRT-PCR The cytokine level in PB was measured. T-lymphocyte proliferation activity, Ig production by B cells, natural killer (NK) cell activity, and the proportion of cluster of differentiation 4 (CD4)/CD8 T cell subsets were detected. Expression of HOTAIR, β-catenin, cyclinD1, GSK-3β, and c-Myc in bone marrow was determined. It was revealed that the WBC number increased, while the PLT number along with the hemoglobin content in PB decreased with the upregulated HOTAIR. Additionally, elevated HOTAIR led to decreased levels of transforming growth factor-β, interferon-γ, interleukin-10, and tumor necrosis factor-α in PB, proliferation activity in T-lymphocyte, and inhibited Ig production, NK cell activity, and the ratio of CD4/CD8 T cell subsets in B-lymphocyte. Furthermore, Wnt/β-catenin was activated by overexpressing HOTAIR. Enhanced survival and proliferation were shown with increased expression of cyclinD1, GSK-3β, and c-Myc in the bone marrow of mice induced by overexpressing HOTAIR. These results indicate that restored HOTAIR reduces the immunologic rejection of leukemia cells in mice by activating Wnt/β-catenin pathway. No 30609034 Hotair LncRNA Mus musculus renal fibrosis renal tissues,cell line Interaction[Notch1 pathway] qRT-PCR Significant elevated HOTAIR and reduced miR-124 were presented in UUO rats and TGF-β1-induced HK-2 cells in a time-dependent manner, with the increased Jagged1 (JAG1), Notch1, NICD, α-SMA and FN, as well as the decreased E-cadherin (all P < 0.05).Compared with the TGF-β1 group, cells in the si-HOTAIR+TGF-β1 group were remarkably declined in cell proliferation and the protein expressions of JAG1, Notch1, NICD, α-SMA, and FN, but dramatically higher in E-cadherin expression (all P < 0.05). However, in comparison with the si-HOTAIR+TGF-β1 group, cells in the si-HOTAIR+miR-124 inhibitor+TGF-β1 group were apparently improved in proliferation and the protein expression of JAG1, Notch1, NICD, α-SMA, and FN, but substantially reduced in the level of E-cadherin protein (all P < 0.05). No 29717517 HOTAIR LncRNA Rattus norvegicus Leukemia, Myelogenous, Chronic, BCR-ABL Positive marrow Epigenetics(methylation) In Vivo Experiment//Western Blot//Transwell Assay//Transfection//CCK8//qRT-PCR//RIP//FISH//Flow Cytometry//Colony Formation Assay//ChIP We found that HOTAIR and DNMT1 expression was increased and PTEN expression was decreased in CML. We also investigated whether downregulated HOTAIR or DNMT1 reduced proliferation, colony formation, invasion, and migration and increased the apoptosis rate of CML cells. Moreover, we tested whether low expression of HOTAIR or DNMT1 reduced the volume and weight of tumors in mice with CML. Collectively, the results of this studied showed that depleted HOTAIR demonstrated reduced binding to DNMT1 to suppress CML progression, which may be related to methylation of the PTEN promoter. No 33941772 HORAS5 LncRNA Homo sapiens Prostatic Neoplasms cell lines Expression[highly expressed] Wound Healing Assay//RNA-seq//Western Blot As a first step, we profiled the expression of HORAS5 in a panel of PCa cell lines. We found that HORAS5 was considerably expressed only in AR‐positive CRPC‐derived cell lines (Sedelaar and Isaacs, 2009; Thalmann et al., 1994), and was undetectable in non‐neoplastic BPH cells (Fig. 2A). Elevated expression of HORAS5 is also associated with worse clinical outcomes in patients. No 30776192 HOPX LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC and para-carcinoma tissues Expression[Expression[lower expressed]-expression] qRT-PCR//Microarray The qRT-PCR assay showed the Expression[Expression[up-expression]-expression]regulation of miR-455-5p, miR-21-3p, miR-96-5p, miR-93-5p, RP11-973H7.5, and HOXC10 expression in LSCC as well as the Expression[down-expression]regulation of miR-486-5p, LINC00657, CTC-297N7.9, hsa_circ_0008832, hsa_circ_0033988, hsa_circ_0001445, hsa_circ_0007013, KRT4, HOPX, TGFBR2, and KDR expression in LSCC (Fig. 11). No 30128795 HNRNPU LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 863 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 HNRNPU LncRNA Homo sapiens Scleroderma, Systemic SSc's peripheral blood mononuclear cells Expression[Expression[lower expressed]-expression] qRT-PCR We profiled 542,500 transcripts in peripheral blood mononuclear cells (PBMCs) from 20 SSc patients and 20 healthy donors using Clariom D arrays, confirming the results by Reverse Transcription Polymerase-chain reaction (RT-PCR). A total of 837 coding-genes were modulated in SSc patients, whereas only one lncRNA, heterogeneous nuclear ribonucleoprotein U processed transcript (ncRNA00201), was significantly Expression[down-expression]regulated. No 30866419 HNRNPKP3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 991 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 HNRNPK-211 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 HNRNPH1P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 887 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 HNRNPH1-227 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 HNRNPCP6 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 806 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 HNMT-208 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 HNF1A-AS1 LncRNA Homo sapiens Multiple Sclerosis blood Expression[lower expressed] qRT-PCR Expression of HNF1A-AS1 was significantly lower in total MS patients and patients of both sexes when compared with the matched controls (P value < 0.0001; P value = 0.03; P value = 0.004, respectively). No 32613554 HNF1A-AS1 LncRNA Homo sapiens bladder urothelial carcinoma UCB tissues Expression[highly expressed] qRT-PCR Data showed that the majority of UCB tissues showed higher HNF1A-AS1 levels than the corresponding normal tissues controls (p < 0.01). Statistical assay revealed that high HNF1A-AS1 expression was significantly correlated with histological grade (p = 0.008), tumor stage T (p = 0.003) and lymph nodes metastasis (p = 0.007). In addition, the overall survival time of patients with high HNF1A-AS1 expression was significantly shorter compared to those with low HNF1A-AS1 expression. No 29762827 HNF1A-AS1 LncRNA Homo sapiens gastric adenocarcinoma GA tissues Expression[differently expression] qRT-PCR//Microarray The expression of 5 differentially expressed lncRNAs, HNF1A-AS1, RP11-62F24.2, GAS5, MALAT1, and H19 were randomly selected to be measured in 47 patients using real-time quantitative reverse transcription PCR (qRT-PCR), and the data were consistent with those obtained from the microarray chip. No 31850717 HOTAIR LncRNA Homo sapiens Pre-Eclampsia Peripheral blood Mutation(HOTAIR rs920778 polymorphism) Bioinformatics Analysis//Genotyping HOTAIR rs920778 increased the risk of preeclampsia under the dominant and recessive inheritance patterns (OR = 4.84, 95% CI: 3.30-7.10, P < 0.0001; OR = 6.86, 95% CI: 3.51-13.42, P < 0.0001; respectively). HOTAIR rs920778 increased the risk of preeclampsia under the dominant and recessive inheritance patterns (OR = 4.84, 95% CI: 3.30-7.10, P < 0.0001; OR = 6.86, 95% CI: 3.51-13.42, P < 0.0001; respectively). No 33264034 HOTAIR LncRNA Homo sapiens transitional cell carcinoma blood Mutation[rs4759314 ] Genotyping We found that female patients who carried AG + GG genotype of rs4759314 were associated with an increased UCC risk after controlling for age and tobacco consumption (adjusted odds ratio (AOR) = 1.92, 95% confidence interval (CI): 1.01⁻3.64, p = 0.047) and a lower overall survival rate (p = 0.008). We found that female patients who carried AG + GG genotype of rs4759314 were associated with an increased UCC risk after controlling for age and tobacco consumption (adjusted odds ratio (AOR) = 1.92, 95% confidence interval (CI): 1.01⁻3.64, p = 0.047) and a lower overall survival rate (p = 0.008). No 30813594 HMGN2P46 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[highly expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 HOTAIR LncRNA Homo sapiens Endometriosis 207 endometriosis patients and 200 healthy women Mutation[rs1838169, rs17720428 ] Cell Proliferation Assay//migration assay Genetic substitutions at rs1838169 and rs17720428 were frequently found in endometriosis patients, and rs1838169 showed statistical significance (p = 0.0174). The G-G (rs1838169-rs17720428) haplotype showed the most significant association with endometriosis (p < 0.0001) with enhanced HOTAIR stability, and patients who harbor such haplotype tended to show higher CA125. No 33667269 HOTAIR LncRNA Homo sapiens Breast Neoplasms Breast Cancer tissues Expression[highly expressed] qRT-PCR However, we observed a significantly increase in the expression of HOTAIR in BC patients compared to normal tissues (P<0.001). Significant associations were found between gene expression and tumour size and margin. We found 91.1% sensitivity and 95.7% specificity of circulating HOTAIR with an area under the ROC curve of 0.969. The Kaplan-Meier analysis indicated significant correlation between HOTAIR expression and overall survival. No 31721532 HOTAIR LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR HOTAIR, upregulated in IDC of breast cancer tissue, could promote breast cancer cell proliferation by regulating cell cycle and apoptosis. No 33136445 HOTAIR LncRNA Homo sapiens Breast Neoplasms serum Expression(highly expressed) qRT-PCR//ELISA The serum levels of HOTAIR, PAI-1, and OPN were significantly higher in breast cancer patients compared to controls and fibroadenoma patients. The serum level of PVT1 was significantly higher in breast cancer patients than in the controls, while that of NEAT1 was significantly lower in breast cancer patients compared to controls and fibroadenoma patients. No 33670447 HOTAIR LncRNA Homo sapiens Breast Neoplasms breast CSCs Interaction(HOTAIR-based NF-κB signaling ) In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay Here, we found that the long noncoding RNA HOTAIR is highly expressed in breast CSCs.Furthermore, our analysis of clinical samples from the GEPIA database indicated that the IκBα level, as well as the survival rate of patients, with high HOTAIR expression was significantly lower than that of patients with relatively low HOTAIR expression. Furthermore, our analysis of clinical samples from the GEPIA database indicated that the IκBα level, as well as the survival rate of patients, with high HOTAIR expression was significantly lower than that of patients with relatively low HOTAIR expression. No 36273585 HOTAIR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung lung cancer tissues Expression(highly expressed) FISH The expression of lncRNA HOTAIR in lung cancer tissues was higher than control or surrounding tissue (p < 0.05). Also, high levels of NSE, CEA and CYFRA21-1 were observed in lung cancer group (p < 0.05). In both N and T stage, the expression of lncRNA HOTAIR combined with NSE, CEA and CYFRA21-1 levels increased with the increase in the number of stages (p < 0.05). No 35959801 HOTAIR LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma Expression[highly expressed] Western Blot//ISH//CCK8//qRT-PCR//Luciferase Report Assay//ELISA//IHC//Invasion Assay HOTAIR expression was markedly higher in ESCC tissues than in non-cancerous esophageal tissues (P < 0.001, Fig. 2A). No 31207321 HOTAIR LncRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR The expression of HOTAIR and H19 showed 7.55- and 11.38-fold increased levels, respectively, in CRC patients compared to the controls (p < 0.001). Furthermore, HOTAIR expression in CRC patients with regional lymph node metastasis was significantly higher when compared with CRC patients without regional lymph node metastasis (p = 0.034). No 31433231 HOTAIR LncRNA Homo sapiens Colorectal Neoplasms Liver Metastatic Colorectal Cancer and adjacent non-cancer liver tissues Expression [highly expressed] PCR We first evaluated expression levels of several lncRNAs in eight excised liver metastases from primary colorectal cancers and found significantly upregulated lncRNAs HOTAIR and MALAT1 along with significantly downregulated LOC285194. A positive signature comprising of high HOTAIR/MALAT1 and low LOC285194 also correlated with progression to higher grade tumors.  No 34307387 HOTAIR LncRNA Homo sapiens Thyroid Cancer, Papillary peripheral venous blood Expression(highly expressed) qRT-PCR//ELISA HOTAIR and Glactin-3 were higher in PTC group and correlated with tumor pathological stage. AUC of Glactin-3 for PTC diagnosis was 0.817, with 66.67% specificity and 78.75% sensitivity. AUC of HOTAIR combining with Glactin-3 for PTC diagnosis was 0.969 with 96.00% specificity and 87.50% sensitivity. AUC of lncRNA HOTAIR was higher than that of Glactin-3, while AUC of the combination was higher than that of lncRNA HOTAIR or Glactin-3. HOTAIR and Glactin-3 were higher in PTC group and correlated with tumor pathological stage. Higher HOTAIR/Glactin-3 expression indicated a more advanced TNM stage. No 34447269 HOTAIR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR The expression level of lncRNA NEAT1, H19, MALAT1, HOTAIR, DANCR, UCA1, and BCAR4 were significantly decreased, compared with that in adjacent noncancerous tissues (all P <.05). The expression level of lncRNA GAS5 was statistically significantly increased (P <.05). For the quantitative polymerase chain reaction (qPCR) assay, 8 kinds of lncRNAs were detected as a result of the GeXP assay. No 30423146 HOTAIR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells regulation[miR-130a-3p/HIF1A] qRT-PCR//RNA Pull-Down//RIP//Western Blot We found that HOTAIR expression was enhanced in HCC tissues and cells. In conclusion, knockdown of HOTAIR suppressed glycolysis by regulating miR-130a-3p and HIF1A in HCC cells treated by hypoxia, elucidating a novel mechanism in HCC glycolysis. No 32062551 HOTAIR LncRNA Homo sapiens Carcinoma, Hepatocellular serum Expression(highly expressed) qRT-PCR The serum levels of HOTAIR, BRM and ICR were significantly higher in HCC patients compared to LC patients and healthy subjects. The HOTAIR level was positively correlated to tumour-node metastasis (TNM), Barcelona Clinic Liver Cancer (BCLC) stage, extrahepatic metastasis, vascular invasion, portal vein tumour thrombus (PVTT), and tumour size. No 36224021 HOTAIR CircRNA Homo sapiens Carcinoma, Hepatocellular Serum Expression(highly expressed) Bioinformatics Analysis Serum HOTAIR was significantly higher in groups IA, IB and II compared to healthy subjects.Serum HOTAIR was significantly higher in group IA than group IB, and in groups IA and IB compared to group II. No 36092759 HOTAIR LncRNA Homo sapiens Carcinoma, Hepatocellular 412 patients Expression(highly expressed) qRT-PCR We found that high expression of HOTAIR was associated with III+IV tumor stage (HR=2.31, 95% CI:1.32, 4.01), and it was not associated with age (HR=0.86, 95% CI:0.55, 1.34), gender (HR=0.91, 95% CI:0.55, 1.46), tumor number (HR=1.58, 95% CI:0.72, 3.48), tumor size (HR=1.54, 95% CI:0.96, 2.49), lymph node metastasis (HR=0.66, 95% CI:0.38, 1.15), AFP (HR=0.81, 95% CI:0.46, 1.42), cirrhosis (HR=1.34, 95% CI:0.75, 2.41), or portal invasion (HR=1.76, 95% CI:0.83, 3.72). A high expression level of HOTAIR was associated with a poorer OS (HR=3.12, 95% CI:1.31-7.43, p=0.010) and RFS (HR=1.67, 95% CI:1.23-2.26, p=0.010) for patients with HCC. No 36459027 HOTAIR LncRNA Homo sapiens Ovarian Neoplasms tissues and cells of ovarian cancer Expression[highly expressed] Flow Cytometry//qRT-PCR//CCK8//Western Blot HOTAIR was upregulated in ovarian cancer. No 30570864 HOTAIR LncRNA Homo sapiens Ovarian Neoplasms ovarian carcinoma tissues and cell lines Regulation[CCND1,CCND2,miR-206 ] qRT-PCR//Northern Blot//Luciferase Report Assay//Western Blot HOTAIR expression was significantly higher in ovarian carcinoma tissues and cell lines than in the control counterparts. HOTAIR enhanced CCND1 and CCND2 expression by negatively modulating miR-206 expression and stimulating the proliferation, cell cycle progression, migration and invasion of ovarian cancer cells. No 30205383 HOTAIR LncRNA Homo sapiens Urinary Bladder Neoplasms bladder tissues Expression[lower expressed] qRT-PCR PV1 was down-regulated in tumor tissues compared with both ANCTs and normal controls (Expression ratios of 0.48 and 0.14; P values of 0.4 and <0.001 respectively). No 31054930 HOTAIR LncRNA Homo sapiens Leukemia, Myeloid, Acute regulation[up-regulated] Meta-analysis Abnormally expressed lncRNAs are significantly related to worse prognoses of AML patients and might serve as potential prognostic markers to predict the prognosis of AML patients. No 33346694 HOTAIR LncRNA Homo sapiens Uterine Cervical Neoplasms plasma Expression[highly expressed] qRT-PCR We discovered 4 lncRNAs including HOTAIR, PVT1, XLOC_000303, and AL592284.1, which were upregulated in CC comparing with the cancer-free controls. No 30134241 HOTAIR LncRNA Homo sapiens Triple Negative Breast Neoplasms Interaction[MiR-146a-5p] qRT-PCR//Transwell Assay We showed that miR-146a-5p and long noncoding RNA HOTAIR were both upregulated in triple-negative breast cancer. MiR-146a-5p positively regulated HOTAIR triple-negative breast cancer cells, while HOTAIR showed no regulatory effects on miR-146a-5p expression. MiR-146a-5p and HOTAIR positively regulated the migration and invasion of triple-negative breast cancer cells. In addition, HOTAIR silencing attenuated the effects of miR-146a-5p. Therefore, overexpression of miR-146a-5p may promote triple-negative breast cancer cell invasion and migration by upregulating HOTAIR. Follow-up study showed that high levels of miR-146a-5p and HOTAIR in tumor tissues were closely correlated with poor survival. No 31672084 HOTAIR LncRNA Homo sapiens Glioma glioma tissues Interaction(miR-126-5p) qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis In this study, we found that HOTAIR was aberrantly up-regulated in glioma tissues and was negatively correlated with miR-126-5p expression. Next, we determined that HOTAIR promote glioma progression by sponging miR-126-5p. Subsequently, glutaminase (GLS) was confirmed to be a direct target of miR-126-5p using bioinformatics software and a luciferase reporter assay. Moreover, HOTAIR could modulate GLS expression by functioning as a competing endogenous RNA (ceRNA) for miR-126-5p. No 29319172 HOTAIR LncRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues and cells Regulation[HOTAIR/miR-101/COX-2 axis] Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay HOTAIR was upregulated in NPC tissues and cells. Here, we highlight the importance of HOTAIR/miR-101/COX-2 axis in progression of nasopharyngeal carcinoma cells. No 30314699 HOTAIR LncRNA Homo sapiens Pancreatic Neoplasms blood Mutation[rs4759314 and rs200349340] Genotyping Our studies revealed that functional SNP rs4759314 and rs200349340 of HOTAIR had strong associations with PC susceptibility. These findings elucidate that functional genetic variants influencing lncRNA expression may explain a portion of PC genetic basis. No 30867650 HOTAIR LncRNA Homo sapiens Adenocarcinoma of Lung adenocarcinoma tissues Expression(highly expressed) qRT-PCR//IHC Both genes were expressed at significantly higher levels in adenocarcinoma tissues than normal lung. EZH2 expression, but not HOTAIR expression, was significantly higher in solid adenocarcinoma than in other subtypes. In the survival analysis using stage-I cases, both HOTAIR expression and EZH2 protein levels were associated with a worse prognosis. The overall survival was highest in the low-HOTAIR and low-EZH2 group (low-low), followed by the high-low or low-high group and the high-high group. No 35245884 HOTAIR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Interaction[miR-221] Flow Cytometry//qRT-PCR//Northern Blot The expression of HOTAIR in tissues of clinical patients only exhibited a correlation with the stage of cancer. Additionally, the expression of HOTAIR was negatively correlated with the expression of miR-221 (r=-0.7651, p<0.0001). Further studies revealed that there was a negatively regulatory interaction between miR-221 expression and HOTAIR expression. Apoptosis assay results manifested that miR-221 significantly promoted the apoptosis of NSCLC cells by negatively regulating HOTAIR expression. The expressions of HOTAIR in patients with stage I and II were remarkably lower than those with stage III and IV. No 31173294 HOTAIR LncRNA Homo sapiens Lupus Erythematosus, Systemic Blood samples Expression(highly expressed) qRT-PCR The serum expression levels of lncRNA-Cox2 and HOTAIR were significantly up-regulated in SLE patients vs HCs (fold change [median (IQR) was 1.29(0.81-1.71, P<0.0001) and 2.68(0.95-3.67), P = 0.038) for lncRNA-Cox2 and HOTAIR, respectively. No 35972968 HOTAIR LncRNA Homo sapiens Diabetes Mellitus, Type 2 peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 HOTAIR LncRNA Homo sapiens Coronary Artery Disease 442 CAD patients and 418 randomly selected control subjects Mutation(rs4759314, rs920778, rs7958904, rs12826786, rs874945, rs1899663 ) Bioinformatics Analysis We selected six single nucleotide polymorphisms, rs4759314 A>G, rs1899663 G>T, rs920778 T>C, rs7958904 G>C, rs12826786 C>T, and rs874945 C>T, for genotype frequency analysis and assessed the frequency of HOTAIR gene polymorphisms in 442 CAD patients and 418 randomly selected control subjects. No 34064346 HOTAIR LncRNA Homo sapiens gastric adenocarcinoma GC tissues Interaction(miR-148b/DNMT1/PCDH10) Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Invasion Assay The expression of HOTAIR was significantly upregulated in GC tissues (p<0.05) and GC cell lines (p<0.01), while PCDH10 was downregulated in GC tissues (p<0.05). The knockdown of HOTAIR (si-HOTAIR1 and 2) significantly upregulated the mRNA/protein expression of PCDH10 and reduced the methylation of PCDH10 compared to the control in MKN 28 and MKN 74. Si-HOTAIR1 and 2 significantly reduced DNA methyltransferase 1 (DNMT1) expression, and overexpression of HOTAIR increased DNMT1 expression. No 33527791 HMlincRNA152 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 HMGN1P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 755 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 HAR1B LncRNA Homo sapiens Carcinoma, Hepatocellular Liver tissues Expression[lower expressed] qRT-PCR The expression levels of HAR1A and HAR1B were significantly lower in the HCC group, compared with the CHB and LC groups (P <.01). HAR1A and HAR1B were negatively associated with histologic grade and TNM (tumor/nodes/metastasis) stage (all P <.05). Univariable multivariable analysis showed that decreased HAR1A (HR = 0.753, P = .02) and HAR1B (HR = 0.551, P = .01) levels were independent predictors for shorter overall survival (OS) in HCC. No 30304523 HERC2P3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 HEIH LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression(highly expressed) qRT-PCR HEIH was upregulated, and DKK3 was downregulated in GC tissues, displaying a negative correlation. Both HEIH and DKK3 were correlated to tumor diameter, lymph node metastasis and TNM staging. No 34565005 HEIH LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung LUSC/LUAD patients Expression(highly expressed) qRT-PCR//ELISA LncRNA HEIH in peripheral blood of LUSC/LUAD patients was higher than that in healthy controls, with no evident difference between LUSC and LUAD groups. I In LUSC/LUAD patients, TNM stage, lymph node metastasis, distal metastasis, and CEA were independent risk factors affecting lncRNA HEIH; patients with high lncRNA HEIH expression had larger pack-years and tumor size, higher CEA level and tumor stage, and higher risk of lymph node metastasis and distal metastasis. High expression of lncRNA HEIH predicted poor prognosis in patients with NSCLC and was an independent risk factor for prognosis of NSCLC. No 35173484 HEIH LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Expression[highly expressed] qRT-PCR qPCR results indicated marked upregulation of CDKN2A-AS1, C7orf55, LINC00184, HEIH, and ZEB2 expression, whereas that of SNHG3, LINC00630, LOC100133669, APTR, LINC-PINT, and SEMA5A was downregulated in OC tissues as compared with levels in normal ovary tissues (Fig. ?(Fig.5b5b). No 31098301 HEIH LncRNA Homo sapiens Coronary Artery Disease plasma of patients with CAD Expression(highly expressed) Bioinformatics Analysis The expression of lncRNA-HEIH in plasma of patients with CAD was remarkably higher than that in the control subjects and was verified to be relevant to the severity of CAD. The expression of lncRNA-HEIH in plasma of patients with CAD was remarkably higher than that in the control subjects and was verified to be relevant to the severity of CAD. Meanwhile, it was found that CAD patients with high expression of lncRNA-HEIH had higher rates of dyslipidemia as well as CAD family history and higher overall incidence of major cardiac adverse events than those with low expression of lncRNA-HEIH. No 35003390 HEIH LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues regulation[TP53] qRT-PCR In the present study, an obvious up-regulation of lncRNA-HEIH was observed in ESCC compared to the adjacent normal tissues.We further found that lncRNA-HEIH was associated with enhancer of zeste homolog 2 (EZH2) and that this association led to the repression of TP53. Meanwhile, patients with high expression of lncRNA-HEIH have significantly poorer prognosis than those with low expression. No 32729661 HECTD1 CircRNA Homo sapiens Ischemic Stroke peripheral blood Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR CircRNA HECTD1 relative expression was higher in AIS patients (1.951 [1.078‐3.423]) than that in controls (0.886 [0.497‐1.296]) (P < 0.001; Figure ​Figure1A).1A). CircRNA HECTD1 expression was higher in AIS patients than that in controls, and the receiver operating characteristic (ROC) curve revealed that circRNA HECTD1 expression was of a good value in distinguishing AIS patients from controls with area under the curve (AUC) of 0.814 (95% CI: 0.768-0.859). In AIS patients, circRNA HECTD1 expression was positively correlated with NIHSS score, CRP, and pro-inflammatory cytokines. CircRNA HECTD1 expression was increased in AIS recurrence patients compared to non-recurrence patients, and further, ROC curve analysis disclosed that circRNA HECTD1 expression predicted higher risk of AIS recurrence (AUC: 0.694, 95% CI: 0.586-0.801). Additionally, circRNA HECTD1 expression was negatively correlated with RFS. No 31257675 HEATR6 LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-16A) Expression[highly expressed] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD10 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 HEATR3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 HDHD2-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 HDAC11-AS1 LncRNA Homo sapiens Atherosclerosis high fat-dieted apoE-/- mice Regulation In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//ELISA//IF In this research, we found that HDAC11-AS1 ameliorated blood lipid levels and atherosclerosis in high fat-dieted apoE-/- mice by regulating HDAC11 negatively. In conclusion, HDAC11-AS1 plays an anti-atherogenic role through adropin to induce LPL expressions, thereby enhancing TG metabolism. The change in blood lipid levels is related to the expression of LPL, which is enhanced by HDAC11-AS1 through regulating adropin histone deacetylation in vitro and in vivo. No 35505157 HCP5 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)72) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 HCP5 LncRNA Homo sapiens Stomach Neoplasms serum of gastric cancer patients Expression(highly expressed) qRT-PCR//FISH The expression level of HCP5 in the serum of gastric cancer patients was remarkably higher than that of healthy controls, and it could distinguish gastritis patients from healthy donors. Besides, the expression of HCP5 was increased dramatically in MKN-45 and MGC-803. Moreover, the high expression of serum HCP5 was related to differentiation, lymph node metastasis, and nerve invasion. No 34222007 HCP5 LncRNA Homo sapiens Osteosarcoma cell lines Interaction[SP1] CCK8//qRT-PCR//Northern Blot At first, five lncRNAs were chosen from GeneCard and subjected to qRT-PCR examination. The results indicated that HCP5 was significantly overexpressed in four OS cell lines.Northern blot assay further proved the higher expression of HCP5 in OS cell lines.Mechanically, HCP5 was found to be activated by the transcription factor SP1. Finally, rescue assays were conducted to demonstrate the function of SP1/HCP5 axis in osteosarcoma. No 30554864 HCP5 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues Expression[highly expressed] qRT-PCR Our study revealed that lncRNA HCP5 expression was upregulated in PC tissues. No 31632071 HCG9 LncRNA Homo sapiens Osteosarcoma osteosarcoma tissues Interaction(miR-34b-3p/RAD51 ) qRT-PCR//Western Blot Osteosarcoma tissues and cell lines expressed higher levels of HCG9 as compared to normal tissues and osteoblasts, and high expression of HCG9 was further proved to be related to metastasis and the grade of osteosarcoma in clinical cases. miR-34b-3p was identified as the target of HCG9, and RAD51 acted as a potential target of miR-34b-3p. Cooverexpressing miR-34b-3p with HCG9 partially suppressed the HCG9-stimulated proliferation, migration, and invasion of osteosarcoma cells in vitro and delayed the tumor progression in vivo. Osteosarcoma tissues and cell lines expressed higher levels of HCG9 as compared to normal tissues and osteoblasts, and high expression of HCG9 was further proved to be related to metastasis and the grade of osteosarcoma in clinical cases. No 34456631 HCG22 LncRNA Homo sapiens Mucocutaneous Lymph Node Syndrome serum Regulation qRT-PCR The results indicated that the serum levels of lncRNAs SRA and HCG22 were higher in patients with acute KD compared with those in healthy controls. B-type natriuretic peptide (BNP) and C-reactive protein were positively correlated with HCG22 in patients with acute KD, while total cholesterol and low-density lipoprotein were negatively correlated with HCG22 in patients with acute KD. No 34373708 HCG18 LncRNA Homo sapiens Stomach Neoplasms Exos derived from GC tissues and cells Interaction(miR-875-3p/KLF4 axis) In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//ELISA//IHC LncRNA HCG18 is highly expressed in Exos derived from GC tissues and cells and the exosomal lncRNA HCG18 regulates M2 macrophage polarization. Mechanistically, lncRNA HCG18 bound to miR-875-3p, miR-875-3p bound to KLF4. Furthermore, GCCs-exosomal lncRNA HCG18 elevated the KLF4 expression by decreasing miR-875-3p in macrophages to facilitate M2 macrophage polarization, thus alleviating GC. No 34735868 HCG18 LncRNA Homo sapiens Osteoporosis bone marrow mesenchymal stem cells regulation[miR-30a-5p/NOTCH1 axis] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Western Blot The expression of HCG18 was increased in BMSCs of OP patients, while the expression of miR-30a-5p was decreased.HCG18 inhibited osteogenic differentiation of BMSCs induced by OP via the miR-30a-5p/NOTCH1 axis. No 33176682 HCG14 LncRNA Homo sapiens Celiac Disease HLA-DR-DQ loci Regulation(NOD1) qRT-PCR//Genotyping Expression of HCG14 was slightly downregulated in epithelial cells isolated from duodenal biopsies of celiac patients, and eQTL analysis revealed that polymorphisms in HCG14 region were associated with decreased NOD1 expression in duodenal intestinal cells. No 29601440 HCG11 LncRNA Homo sapiens Glioma glioma tissues and cell lines Regulation[miR-4425/MTA3 axis] qRT-PCR//Luciferase Report Assay HCG11 was downregulated in 84 pairs of glioma tissues and cell lines. Regarding the mechanism, HCG11 was abundant in the cytoplasm of glioma cells and interacted with miR-4425 to release the expression of MTA3. miR-4425 and MTA3 participated in HCG11-mediated glioma growth. Moreover, a low level of HCG11 indicted the lower overall survival rate of glioma patients. No 30706982 HCG11 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Interaction(IGF2BP2/LATS1) In Vivo Experiment//Transfection//MeRIP//qRT-PCR//FISH//RIP//Bioinformatics Analysis//IF Our data revealed that lncRNA HCG11 expression was downregulated in LUAD, which was modulated by the hypermethylation of HCG11 promoter and Methyltransferase Like 14 (METTL14) mediated N6-methyladenosine (m6A) modification. The m6A modification of HCG11 promoted its nuclear exportation and binding by Insulin Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2), resulting in increased stability. HCG11 could recruit IGF2BP2 to target Large Tumor Suppressor Kinase 1 (LATS1) mRNA to enhance the stability and promote the expression of LATS1. HCG11 served as a tumor suppressor to restrain tumor growth in LUAD by regulating LATS1. No 34624573 HCCL5 LncRNA Homo sapiens Carcinoma, Hepatocellular cell lines Interaction[ZEB1 ] Northern Blot//Western Blot//ISH//Wound Healing Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Transwell Assay Moreover, HCCL5 was upregulated in TGF-β1-induced classical epithelial-to-mesenchymal transition (EMT) models, and this lncRNA in turn accelerated the EMT phenotype by upregulating the expression of transcription factors Snail, Slug, ZEB1, and Twist1. HCCL5 was transcriptionally driven by ZEB1 via a super-enhancer and was significantly and frequently overexpressed in human HCC tissues, correlating with worse overall survival of patients with HCC. No 30482773 HBG1-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 HAUS7 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)10) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 HAUS4 CircRNA Homo sapiens Alzheimer Disease cerebrospinal fluid Expression[lower expressed] qRT-PCR//Microarray By RT-qPCR, circ-LPAR1, circ-AXL and circ-GPHN were increased, whereas circ-PCCA, circ-HAUS4, circ-KIF18B and circ-TTC43C were decreased in AD patients compared with Ctrl subjects, and these circRNAs were disclosed to predict AD risk by receiver operating characteristics curve analysis. No 32315771 HAT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 HAS2-AS1-216 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 HAS2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 HAR1B LncRNA Homo sapiens Colorectal Neoplasms CRC samples Expression(highly expressed) qRT-PCR Upregulated JPX and HAR1B lncRNAs may contribute to colorectal cancer pathobiology by affecting multiple cancer-related signaling pathways. No 35526243 HELZ2 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 HERC2P3-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 HMGB1P39 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1019 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 HGD-207 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 HMGA1P4 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR//Microarray The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated). No 32020063 HM13-AS1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 HLA-F-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 HLA-F-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cells Interaction(miR-375/PFN1 ) CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Transwell Assay The results indicated that the HLA-F-AS1 expression pattern was increased in the CRC tissues and cells, which promoted the migration, invasion, and EMT of CRC cells in vitro.Mechanistically, HLA-F-AS1 competitively bound to miR-375 and inversely regulated miR-375 expression pattern. Interestingly, PFN1 was identified as a direct target of miR-375, and positively modulated by HLA-F-AS1 by binding to miR-375. No 33531647 HLA-DQB1-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Mutation(rs2647046) qRT-PCR//Luciferase Report Assay Allele-specific chromosome conformation capture assays revealed that enhancer with rs2647046 interacted with the HLA-DQB1-AS1 promoter to allele-specifically influence its expression by CTCF-mediated long-range loop. No 34665859 HLA-DQB1-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Expression [lower expressed] Survival Analysis In this study, autophagy-related mRNAs-lncRNAs were screened from lung adenocarcinoma and a co-expression network of autophagy-related mRNAs-lncRNAs was constructed by using The Cancer Genome Atlas (TCGA). The univariate and multivariate Cox proportional hazard analyses were used to evaluate the prognostic value of the autophagy-related lncRNAs and finally obtained a survival model composed of 17 autophagy-related lncRNAs. No 33987935 HLA-DQA1-205 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 HLA-DPB2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 HLA-DPB1-217 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 HLA-DPB1-213 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 HIX0026549 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] Microarray Moreover, the intersection analysis between 130 gene symbols and 73 gene symbols showed a total of nine miRNAs, and the number of targeted lncRNA was 11, which served as the differentially expressed lncRNA (Table 1). No 35117179 HIX0011161 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] Microarray Moreover, the intersection analysis between 130 gene symbols and 73 gene symbols showed a total of nine miRNAs, and the number of targeted lncRNA was 11, which served as the differentially expressed lncRNA (Table 1). No 35117179 HIX0000266 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] Microarray Moreover, the intersection analysis between 130 gene symbols and 73 gene symbols showed a total of nine miRNAs, and the number of targeted lncRNA was 11, which served as the differentially expressed lncRNA (Table 1). No 35117179 HIT000301840 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[highly expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 HIT000218960 LncRNA Homo sapiens Stomach Neoplasms GC tissues from 103 cases Expression(highly expressed) qRT-PCR//IHC It was revealed that HIT000218960 was highly expressed in GC tissues and HIT000218960 levels in GC tissues from 103 cases were positively correlated with high mobility group AT-hook 2 (HMGA2) mRNA expression. Furthermore, HIT000218960 was significantly associated with tumor diameter, TNM stage, histological grade, the number of lymph nodes with metastasis and HMGA2 expression in tumor tissues of patients with GC. No 34055048 HIT LncRNA Homo sapiens Breast Neoplasms serum Expression(highly expressed) qRT-PCR Increased ANRIL (3.83-fold), TUG1 (7.64-fold), UCA1 (7.82-fold), and HIT (3.31-fold) expressions were observed in breast cancer patients compared to healthy controls. While lncRNA TUG-1 expression was found to be higher in patients with early-stage tumors than those with advanced-stage tumors (p = 0.06), lncRNA ANRIL showed increased expression in patients with PR positive status (p = 0.04). However, we found a significant difference in lncRNA HIT expression in HER-2 positive breast cancer patients compared to HER-2 negative breast cancer patients (p = 0.005). An increase in the expression of serum lncRNAs ANRIL (p < 0.0001), UCA-1 (p = 0.004), and HIT (p < 0.0001) was observed in the distant organ metastatic breast cancer patients. No 35132340 HISLA LncRNA Homo sapiens Arthritis, Rheumatoid peripheral blood mononuclear cells Expression[lower expressed] qRT-PCR//RNA-seq In the present study, 231 upregulated and 110 downregulated lncRNAs were identified as differentially expressed in patients with RA compared with the controls. Information on the top 6 up- or downregulated lncRNAs is provided in Table III. No 33456537 HIPK3 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 HIGD1AP7 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 918 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 HIGD1A-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 HIF1A-AS2 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC tissues,blood Expression[highly expressed] qRT-PCR The expression of serum exosomal aHIF was higher in EOC patients and was correlated with the aHIF level in EOC tissues. Kaplan-Meier survival analysis demonstrated that EOC patients with higher serum exosomal aHIF expression had poorer overall survival.. Cox multivariate regression model revealed that FIGO stage, residual tumor size, and serum exosomal aHIF level were independent prognostic factors of EOC. No 31571921 HIF1A-AS2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 965 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 HIF1A-AS2 LncRNA Homo sapiens Coronary Artery Disease blood Expression[highly expressed] qRT-PCR We found that the levels of lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1), hypoxia-inducible factor 1 alpha-antisense RNA 2 (HIF1A-AS2) and apolipoprotein A-1 antisense RNA (APOA1-AS) were significantly increased in CAD patients (KCNQ1OT1 increased by 2.38-fold, P = 0.00042; HIF1A-AS2 increased by 2.00-fold, P = 0.0001; APOA1-AS increased by 4.52-fold, P = 0.000048). No 30941792 HIF1A-AS2 LncRNA Homo sapiens Endometriosis exosomal Expression[highly expressed] qRT-PCR Clinically, aHIF was highly expressed in ectopic endometria and serum exosomes in patients with endometriosis. No 30808247 HIF1A-AS2 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Expression[highly expressed] Microarray LncRNAs HIF1A-AS2 and AK124454 were upregulated in TNBCs. No 33542899 HIF1A-AS2 LncRNA Homo sapiens Stroke all stroke groups Expression(highly expressed) ELISA Remarkable upregulation of lncRNA HIF1A-AS2 and HIF1-α along with a downregulation of lncRNA LINK-A was noticed in all stroke groups relative to controls. No 34091825 HIF1A-AS2 LncRNA Mus musculus Atherosclerosis thoracic aorta regulation[inhibits ATF2] RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA//ChIP It was established that lncRNA HIF1A-AS2 and ATF2 were highly expressed in atherosclerotic ApoE-/- mice. Collectively, the present study demonstrates that downregulation of lncRNA HIF1A-AS2 represses the binding of USF1 to the ATF2 promoter region and then inhibits ATF2 expression, thereby suppressing atherosclerotic inflammation. No 33133688 HIF1A-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues regulation[HIF-1α/mTOR-mediated autophagy] CCK8//qRT-PCR HIF1A-AS1 was overexpressed in HCC tissues and was associated with tumor size, TNM stage, and lymph node metastasis. HIF1A-AS1 was overexpressed in HCC tissues and was associated with tumor size, TNM stage, and lymph node metastasis. Compared with the low HIF1A-AS1 group, the high HIF1A-AS1 group had a shorter overall survival and a worse disease-free survival. No 32473641 HIF1A LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-22A) Expression[no-differently] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD16 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 GNB1-207 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 GNAS-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues,cell lines Regulation[GNAS-AS1/miR-4319/NECAB3 axis] Western Blot//qRT-PCR//MTT//ELISA//Transwell Assay GNAS-AS1 expression was dramatically enhanced in TAM, NSCLC cell lines, and clinical tumor tissues, and negatively correlated with overall survival of NSCLC patients. GNAS-AS1/miR-4319/NECAB3 axis promotes tumor progression of NSCLC by altering macrophage polarization. GNAS-AS1 expression was dramatically enhanced in TAM, NSCLC cell lines, and clinical tumor tissues, and negatively correlated with overall survival of NSCLC patients. No 31267263 FABP6-AS1 LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 FGFR2-219 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 FGF14-AS2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FGF12-AS2 LncRNA Homo sapiens Adenocarcinoma of Lung TCGA(LUAD cancer and normal samples) Regulation Survival Analysis Herein, we identified an eight-lncRNA signature (PR-lncRNA signature, NPSR1-AS1, SATB2-AS1, LINC01090, FGF12-AS2, AC005256.1, MAFA-AS1, BFSP2-AS1, and CPC5-AS1), which contributes to predicting LUAD patient's prognosis risk and survival outcomes. Of them, NPSR1-AS1, SATB2-AS1, FGF12-AS2, and AC005256.1 could be acted as the poor prognosis markers, while LINC01090, MAFA-AS1, BFSP2-AS1, and CPC5-AS1 were treated as the protective factors for survival in LUAD patients. No 34550610 FGF12-AS1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 FGF10AS LncRNA Homo sapiens Colorectal Neoplasms tumour tissues Expression(highly expressed) qRT-PCR A significant increase in expression was observed in FGF10 (P<0.001) along with a significant decrease in FGF10AS (P<0.02) in the tumour tissues in comparison with the adjacent normal tissues. Upregulation of FGF10 and downregulation of FGF10AS expression were strongly correlated with the Tumour, Node, Metastasis (TNM) stage (P<0.007 and P<0.004), vascular invasion (P<0.03 and P<0.01), lymph invasion (P<0.02 and P<0.04), and differentiation (P<0.01 and P<0.02), respectively. No 34939760 FGD5-AS1 LncRNA Homo sapiens Osteosarcoma osteosarcoma cell Interaction(miR-124-3p/G3BP2 axis) qRT-PCR//FISH EBF1 induced-FGA5-AS1 aggravated osteosarcoma cell malignancy by targeting miR-124-3p and G3BP2. No 35761386 FGD5-AS1 LncRNA Homo sapiens Melanoma melanoma specimens Expression[highly expressed] qRT-PCR We observed that FGD5-AS1 in melanoma specimens was distinctly up-regulated compared to adjacent non-tumor specimens (p < 0.01). In malignant cases, higher expression of FGD5-AS1 was prominently associated with tumor thickness (p = 0.024) and advanced tumor stage (p = 0.039). The data from our clinical study revealed that patients with high FGD5-AS1 expression had a distinctly shorter overall survival (p = 0.0034) and disease-free survival (p < 0.0001) than those with low FGD5-AS1 expression. Multivariate analysis demonstrated that high FGD5-AS1 expression may serve as a potential independent prognostic factor in melanoma. No 32997827 FGD5-AS1 LncRNA Homo sapiens Heart Defects, Congenital HEK 293 and the fetal heart cell line (CCC-HEH-2) Interaction( hsa-miR-421/PTEN and SMAD4) Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//RNA-seq//Cell Apoptosis Assay//Cell Proliferation Assay Both FGD5-AS1 and SMAD4 could bind with hsa-miR-421, which has been validated using dual-luciferase reporter assays. Knockdown of FGD5-AS1 not only significantly reduced PTEN and SMAD4 expression in HEK 293 and the fetal heart cell line (CCC-HEH-2) but also increased the transcription of its interacted miRNAs in a cell-specific way. No 34046402 FGD5-AS1 LncRNA Homo sapiens Sars-Cov-2 Vaccination Breakthrough Infections 57 VBT and unvaccinated COVID-19 patients Expression(lower expressed) RNA-seq//Bioinformatics Analysis Further, out of the 12 lncRNA genes, 7 lncRNAs are reported to modulate immune/inflammatory responses in infectious diseases. Out of the 7 lncRNAs, LUCAT1, MALAT1, NEAT1 and GAS5 were downregulated in the VBT. LUCAT1 is a negative regulator of interferon response, and downregulation of LUCAT1 suggests an activated interferon response (30). MALAT1 is known to negatively regulate the immune response and positively regulate the inflammatory response in the infected individuals, therefore downregulation of MALAT1 in the breakthrough infection suggests an upregulated immune response and downregulated inflammatory response (31, 32). NEAT1 and GAS5 also act as pro-inflammatory lncRNAs, and their downregulation is an indicator of decreased inflammatory response in the VBT (33, 34). Amongst the upregulated lncRNAs, ROR1-AS1, UGDH-AS1 and LINC00273 were upregulated in the VBT. The upregulation of ROR1-AS1 and LINC00273 indicates a heightened immune response, whereas upregulation of UGDH-AS1 suggests a decreased disease severity possibly modulated by MOV10 and EDN1 (8). No 36466827 FEZF1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FEZF1-AS1 LncRNA Homo sapiens Glioblastoma GBM tissues regulation[Sponges miR-34a,Upregulate Notch-1] qRT-PCR//Transwell Assay In this study, analysis of TCGA dataset revealed the upregulation of FEZF1-AS1 in GBM, and the overexpression of FEZF1-AS1 in GBM was further confirmed using GBM tissues from GBM patients included in this study. FEZF1-AS1 may sponge miR-34a to upregulate Notch-1 in GBM, thereby promoting cancer cell invasion and migration. High levels of FEZF1-AS1 were correlated with poor survival. No 32210625 FEZF1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[highly expressed] qRT-PCR//Microarray The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated). No 32020063 FEZF1-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Plasma Expression[highly expressed] qRT-PCR Plasma FEZF1-AS1 of the NSCLC group was increased compared with that in the control group (P < .0001). No 32590821 FER1L6-AS2 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial 35 cases of EOC patients (malignant group) and 20 cases of benign ovarian tumor patients (benign group) Expression(highly expressed) qRT-PCR Compared with the benign and normal groups, the expression of FER1L6-AS2, LINC00470 and LINC01811 in malignant group increased by 1.66 and 1.84-fold, 2.05 and 2.46-fold, 2.94 and 2.35-fold, respectively; the expressions of CXXC4-AS1, LINC02343 and LINC02428 were down-regulated to 29% and 34%, 40% and 46%, 42% and 42%, respectively. No 35385957 FER1L4 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] qRT-PCR FER1L4 expression is higher in tumor tissues compared with the adjacent nontumor tissues. No 31332783 FER1L4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FER1L4 LncRNA Homo sapiens Colorectal Neoplasms 50 paired colorectal tumors and non-tumor marginal tissues, 30 paired adenomatous colorectal polyps (ACPs) and matched adjacent normal tissues Expression(lower expressed) Bioinformatics Analysis Despite the downregulation of FER1L4 and upregulation of RB1 in tumors compared with non-tumor tissues, the expression of RB1 was positively correlated with the expression of FER1L4 in the colorectal tumor as well as in the polyp tissues. FER1L4 expression level might be considered as a potential biomarker for colorectal cancer development. No 34132945 FER1L4 LncRNA Homo sapiens Endometrial Neoplasms EC tissues Expression[lower expressed] qRT-PCR We observed that FER1L4 in EC tissues was significantly down-regulated compared with adjacent non-tumor tissues (p<0.01). Low expression of FER1L4 was significantly correlated with distant metastasis (p=0.002), lymph node metastasis (p=0.010) and FIGO stages (p=0.006). Furthermore, Kaplan-Meier survival curves showed that overall survival rate in patients with high FER1L4 expression level was markedly higher than those with low FER1L4 expression level (p=0.0071). No 30556848 FER1L4 LncRNA Homo sapiens Osteosarcoma osteosarcoma samples Expression[lower expressed] qRT-PCR LncRNA FER1L4 expression was decreased in osteosarcoma samples. LncRNA FER1L4 was not related to the gender and age of patients, but was significantly associated with disease stage, metastasis, and tumor differentiation. No 29762833 FER1L4 LncRNA Homo sapiens Arthritis, Rheumatoid synovial tissues Interaction[targeting NLRC5 ] qRT-PCR//MTT//Western Blot//FISH The level of FER1L4 significantly reduced in STs and FLSs, whereas the nucleotide oligomerisation domain-like receptors 5 (NLRC5) levels were increased.These results indicated that FER1L4 regulates RA via targeting NLRC5 potentially. No 31694750 FER1L4 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues Expression[highly expressed] qRT-PCR Fer1L4 lncRNA is overexpressed in ccRCC compared to adjacent normal tissues. Increased expression significantly correlates with tumor aggressiveness: high expression levels of Fer1L4 RNA were found in higher grade, higher stage, and metastatic tumors. No 31965534 FENDRR-203 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[lower expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 FENDRR-005 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC and matched adjacent non-tumor lung tissues Expression[lower expressed] qRT-PCR//Microarray FENDRR-005 and LINC00968-007 were downregulated in NSCLC compared with matched adjacent normal tissues, and DLEU1 and LINC01616 were upregulated in NSCLC compared with matched adjacent normal tissues. No 31348244 FENDRR LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and HCC tissues regulation[Targeting miR-362-5p Via NPR3 and p38-MAPK Pathway] Flow Cytometry//qRT-PCR//MTT//Western Blot FENDRR expression was downregulated while miR-362-5p expression was upregulated in HCC tissues and cells. FENDRR inhibited HCC cells viability yet promoted apoptosis by targeting miR-362-5p by promoting NPR3 and deactivating p38-MAPK pathway, thus exerting its anticarcinogenic effects in HCC cells. No 32251605 FENDRR LncRNA Homo sapiens Gastrointestinal Stromal Tumors GIST and adjacent tissue Expression[highly expressed] RNA-seq However, only H19 and FENDRR showed significant upregulation in the validation cohort (adjusted p < 0.05). No 30557328 FENDRR LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues and cells regulation[TUBA1A, miR-15a/b-5p] qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP FENDRR was downregulated in CC tissues and cells, which suppressed CC progression. FENDRR inhibits CC progression through upregulating TUBA1A in a miR-15a/b-5p-dependent manner. No 32398968 FENDRR LncRNA Homo sapiens Adenocarcinoma of Lung lung adenocarcinoma tissues Expression[lower expressed] qRT-PCR//FISH FENDRR expression measured by quantitative PCR was found significantly downregulated (p<0.001) in lung adenocarcinoma samples in comparison with their normal adjacent tissues (n=70). No 32284793 FENDRR LncRNA Homo sapiens Idiopathic Pulmonary Fibrosis blood Expression[lower expressed] qRT-PCR//Microarray We confirmed the downregulation of FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR) lncRNA, hsa_circ_0001924 circularRNA, utrophin (UTRN) and Y-box binding protein 3 (YBX3) mRNAs. No 33233868 FENDRR LncRNA Homo sapiens lung squamous cell carcinoma LUSC samples Expression[lower expressed] CCK8//Colony Formation Assay//Flow Cytometry//Western Blot Our results showed that CTD-2562J17.6 and FENDRR were significantly downregulated while MIR205HG, LNC_000378, RP11-116G8.5, RP3-523K23.2, and RP5-968D22.1 were significantly upregulated in all five LUSC samples. Importantly, MIR205HG was upregulated in LUSC clinical samples as well as in LUSC cell lines. No 32188965 FENDRR LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[lower expressed] qRT-PCR//Microarray The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated). No 32020063 FGF14-IT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FGFRL1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 FDPSP2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FHL1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 FOXN3-AS1 LncRNA Homo sapiens Breast Neoplasms breast cancer samples Expression(highly expressed) qRT-PCR The FOXN3-AS1 expression level was significantly increased in breast cancer samples compared with ANCTs (P value = 0.02), Also its amounts could distinguish two sets of samples with an accuracy of 70% (P value = 0.009). The FOXN3-AS1 expression level was significantly increased in breast cancer samples compared with ANCTs (P value = 0.02), Also its amounts could distinguish two sets of samples with an accuracy of 70% (P value = 0.009). We have found an association between FOXN3-AS1 expression and tumor size (P value = 0.02). The FOXN3-AS1 expression level was significantly increased in breast cancer samples compared with ANCTs (P value = 0.02), Also its amounts could distinguish two sets of samples with an accuracy of 70% (P value = 0.009). No 34703931 FOXJ3 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 FOXD3-AS1 LncRNA Homo sapiens Lung Neoplasms LUAD, LUSC, and SCLC tissues Expression(highly expressed) qRT-PCR//Bioinformatics Analysis According to public datasets, the lncRNA forkhead box D3 antisense 1 (FOXD3-AS1) was significantly upregulated in LUAD, LUSC, and SCLC tissues over controls. No 36159563 FOXD2-AS1 LncRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR Compared with healthy subjects, the levels of plasma lncRNAs PANDAR, FOXD2-AS1, and SMARCC2 were all significantly higher in gastric cancer patients (P<0.05). These lncRNAs were significantly associated with clinicopathological parameters of gastric cancer, like pathological differentiation, TNM stage, and/or lymph nodes metastasis, and/or invasion depth (P<0.05). The AUC for lncRNA PANDAR was 0.767, for FOXD2-AS1 was 0.700, for SMARCC2 was 0.748, and the AUC of the combinative diagnostic value of these three lncRNAs was 0.839. Adjusted by other variables, these lncRNAs' expressions were significantly associated with gastric cancer. No 31308753 FOXD2-AS1 LncRNA Homo sapiens Breast Neoplasms 71 luminal A and B tumor tissues and two luminal A cell lines Expression(highly expressed) qRT-PCR//Bioinformatics Analysis The results showed the significant upregulation of all three lncRNAs in luminal A and B tumor specimens and cell lines. Upregulation of DUXAP8 and FOXD2-AS1 was significantly associated with progesterone receptor-positive (PR+) and p53 protein expression in luminal BC patients, respectively. No 34043149 FOXD2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FOXD2-AS1 LncRNA Homo sapiens Colorectal Neoplasms Exosomal Expression(highly expressed) qRT-PCR Exosomal FOXD2-AS1, NRIR, and XLOC_009459 (TCONS_00020073) levels were significantly upregulated in 203 CRC patients and 80 early-stage CRC patients compared to 201 healthy donors, possessing the area under the curve (AUC) of 0.728, 0.660, and 0.682 for CRC, as well as 0.743, 0.660, and 0.689 for early-stage CRC, respectively. No 33777763 FOXD2-AS1 LncRNA Homo sapiens Colorectal Neoplasms tumor tissues Expression(highly expressed) qRT-PCR The obtained results showed that the expression level of FOXD2-AS1 gene was significantly (p<0.0001) up-regulated in tumor tissues compared to normal marginal tissues. Also, a significant correlation was observed between higher the expression of FOXD2-AS1and the differentiation of tumor cells. Furthermore, ROC curve analysis estimated an AUC value of 0.59 for FOXD2-AS1, suggesting its potential as a diagnostic target. No 36718294 FOXD2-AS1 LncRNA Homo sapiens Stomach Neoplasms Expression [highly expressed] qRT-PCR FOXD2-AS1 was significantly upregulated in tumor samples as compared to non-tumor tissues (P < 0.0001). In addition, higher expression of FOXD2-AS1 was significantly associated with lymph node metastasis and Helicobacter pylori infection. No 34478035 FOXD2-AS1 LncRNA Homo sapiens pancreatic adenocarcinoma PAAD tissues and cells Interaction( PAAD cell and tissues) qRT-PCR//Transwell Assay Analysis of the TCGA dataset revealed that FOXD2-AS1 was upregulated in PAAD tissues compared to the non-cancer tissues (1.89 vs. 0.2 TPM), indicating potential involvement of FOXD2-AS1 in PAAD. Our own data also showed FOXD2-AS1 was overexpressed in PAAD. It is predicted that miR-30a-3p can bind FOXD2-AS1, while their overexpression did not affect each other's expression. Correlation analysis revealed a significant correlation between FOXD2-AS1 and COX-2. In addition, FOXD2-AS1 overexpression increased COX-2 level, while miR-30a-3p played an opposite role. FOXD2-AS1 and COX-2 overexpression increased PAAD cell invasion and migration. MiR-30a-3p played an opposite role and inhibited the effects of FOXD2-AS1 and COX-2 overexpression. Moreover, high FOXD2-AS1 levels predicted poor survival. No 35377978 FOXD2.AS1 LncRNA Homo sapiens Breast Neoplasms TCGA(1,104 tumor samples and 292 normal samples) Regulation Bioinformatics Analysis In total, five metabolism-related lncRNAs were enrolled to establish prognostic signatures. Further analysis demonstrated that the signature was an independent prognostic factor for BC. No 34254565 FOXC2-AS1 LncRNA Homo sapiens Osteosarcoma OS tissues and cells Interaction(miR-6874-3p/IL-6) CCK8//qRT-PCR ODRUL and IL-6 were highly expressed in OS cells and tissues, while miR-6874-3p was expressed at low levels. The overall survival of high miR-6874-3p expression of OS patients was longer than that of low miR-6874-3p expression of OS patients. MiR-6874-3p overexpression markedly inhibited the progression of OS cells. Both ODRUL and IL-6 could bind to miR-6874-3p at the predicted binding sites which were authenticated by dual-luciferase reporter gene assay. MiR-6874-3p could inhibit OS cell proliferation and metastasis and ODRUL could reverse the suppression induced by miR-6874-3p in vivo. In conclusion, ODRUL could effectively sponge miR-6874-3p to upregulate the expression of IL-6 in OS progression. The overall survival of high miR-6874-3p expression of OS patients was longer than that of low miR-6874-3p expression of OS patients. No 35114192 FOXC1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Expression(highly expressed) Microarray The results of qRT-PCR confirmed notable upregulation of FOXC1, lnc-FOXCUT, and lnc-DANCR in TNBC tissues compared to non-TNBC samples (P < 0.0001, P = 0.0005, and P = 0.0008, respectively). Moreover, ROC curve analysis revealed the potential biomarker role of FOXC1 in TNBC samples. No 35066769 FOSL2-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 FMO9P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FMO6P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FMC1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Expression[highly expressed] qRT-PCR qPCR results indicated marked upregulation of CDKN2A-AS1, C7orf55, LINC00184, HEIH, and ZEB2 expression, whereas that of SNHG3, LINC00630, LOC100133669, APTR, LINC-PINT, and SEMA5A was downregulated in OC tissues as compared with levels in normal ovary tissues (Fig. ?(Fig.5b5b). No 31098301 FLVCR1-DT LncRNA Homo sapiens COVID-19 COVID-19 patients Expression(highly expressed) qRT-PCR Results revealed the decreased expression of A2M-AS1 and FLVCR1 in COVID-19 patients. Additionally, they showed the increased expression of DBH-AS1, FLVCR1-DT, and NCBP2AS2. Both FLVCR1-DT and NCBP2AS2 showed a positive correlation with interleukin-6 (IL-6). DBH-AS1 and FLVCR1-DT had a significant association with mortality, complications, and mechanical ventilation. A significant negative correlation was found between A2M-AS1 and NCBP2AS2-1 and between FLVCR1 and FLVCR1-DT. No 36359290 FLJ42393 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FLJ40194-201 LncRNA Homo sapiens Cardiomyopathy, Dilated blood Expression[highly expressed] qRT-PCR//RNA-seq The top 10 upregulated lncRNAs presenting the highest fold-change were TCONS_00028585, ENST00000439796, TCONS_l2_00009351, ENST00000448134, ENST00000607876, TCONS_00015639, ENST00000489016, TCONS_00011165, ENST00000322227 and ENST00000458361. The top 10 downregulated lncRNAs presenting the highest fold-change were TCONS_00003609, TCONS_00018640, ENST00000606664, uc003uey.1, ENST00000494231, ENST00000419628, ENST00000435049, ENST00000609755, TCONS_00026839 and ENST00 000500180 (Fig. 3A). No 30720098 FLJ31356 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FLJ23867 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FLJ20021 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[lower expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 FLG-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FKBP9P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FKBP1A-SDCBP2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FKBP14 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FIRRE LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 Firre LncRNA Rattus norvegicus Pulmonary Fibrosis lung tissues Expression[lower expressed] Microarray The top 10 upregulated and 10 downregulated lncRNAs with the highest fold change were listed in Table 1. No 30978436 FENDRR LncRNA Homo sapiens Cardiomyopathy, Hypertrophic 238 HCM patients and 212 controls Mutation(rs39527, rs39529 and rs40384) RNA-seq//Genotyping We observed by NGS that FENDRR rs39527, rs39529 and rs40384 polymorphisms were significantly associated with HCM in our cohort (p = 0.0284; OR: 0.24, 95%CI: 0.07?0.86). NGS results were confirmed by genotyping rs74035787 polymorphism (p = 0.001; OR:0.38, 95%CI: 0.21?0.66). Moreover, it is also associated when stratification by sex (p = 0.003; OR:0.20, 95%CI: 0.06?0.53), and age (≥50 years old p = 0.001, OR:0.33, 95%CI: 0.16?0.63) Moreover, the risk of HCM in the carriers of the GG genotype of the rs1424019 polymorphism was significantly higher than that of the AA/AG genotypes carriers in the elderly subjects (p = 0.045, OR:1.24, 95%CI: 1.01?1.53). On the other hand, we observed significant differences in the rs74035787 A/rs1424019 G haplotype frequency (p = 0.0035; OR: 0.20, 95%CI: 0.07?0.59). No 35743849 FCHO2-DT-201 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 FOXP1-DT-201 LncRNA Homo sapiens Graves Disease serum Regulation(FOXP1 ) qRT-PCR Among the selected lncRNAs, the relative expression of ENST00000604491 was significantly downregulated and negatively correlated with the serum levels of thyroid-stimulating hormone receptor antibodies (TRAb) in GD patients. Further studies confirmed that decreased FOXP1 expression was inversely correlated with serum TRAb levels in GD patients. Moreover, there was a notably positive correlation between ENST00000604491 expression and FOXP1 transcript levels in GD. No 35509980 fantom3_4930418C01 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 FANCF LncRNA Homo sapiens Coronary Disease blood Expression[lower expressed] qRT-PCR The expression of LncRNA FAF in the serum of patients in the RG was significantly lower than that in the CG, and the expressions of HCY, Lp-a, TNF-α, and hsCRP were significantly higher than those in the CG (p <0.05). LncRNA FAF was lowly expressed in the serum of patients with coronary heart disease, and it was of high value in the diagnosis and prediction of poor prognosis of coronary heart disease. It was also an independent risk factor for poor prognosis of patients with coronary heart disease and may be a potential target for diagnosis and treatment of coronary heart disease. No 33204729 FAM95C LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FAM95B1 LncRNA Homo sapiens Arthritis, Rheumatoid peripheral blood mononuclear cells Expression[lower expressed] qRT-PCR//RNA-seq In the present study, 231 upregulated and 110 downregulated lncRNAs were identified as differentially expressed in patients with RA compared with the controls. Information on the top 6 up- or downregulated lncRNAs is provided in Table III. No 33456537 FAM86JP LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FAM86DP LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FAM83A-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Expression [highly expressed] Survival Analysis In this study, autophagy-related mRNAs-lncRNAs were screened from lung adenocarcinoma and a co-expression network of autophagy-related mRNAs-lncRNAs was constructed by using The Cancer Genome Atlas (TCGA). The univariate and multivariate Cox proportional hazard analyses were used to evaluate the prognostic value of the autophagy-related lncRNAs and finally obtained a survival model composed of 20 autophagy-related lncRNAs. No 33987935 FAM66B-207 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 FAM66B-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 FAM66B LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 687 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 FAM66A LncRNA Homo sapiens Adenocarcinoma of Lung otherwise non-metastasis and healthy adults Regulation RNA-seq LncRNA family with sequence similarity 66 member A (FAM66A) and lncRNA PSORS1C3 were found to be associated with tumor metastasis. LncRNA family with sequence similarity 66 member A (FAM66A) and lncRNA PSORS1C3 were found to be associated with tumor metastasis. No 36388820 FAM49B-AS LncRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] Microarray A two-stage validation revealed that plasma levels of three lncRNAs (FAM49B-AS, GUSBP11, and CTDHUT) were significantly higher in GC plasma as compared with healthy controls (P < 0.05), and the combined area under curve of these lncRNAs was 0.818 (95% CI 0.772-0.864). No 30603909 FAM3C CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 FAM30A LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Regulation[PI3K-Akt signaling pathway] qRT-PCR//RNA-seq Notably, the qPCR assay confirmed that KIAA0125 and MSTRG.35002.1 were significantly downregulated in both ES and LS colon tumor tissues compared with normal colon tissues. No 31043791 FAM30A LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[highly expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 FAM30A LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[highly expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 8 No 32547537 FAM30A LncRNA Homo sapiens Ameloblastoma Dental follicle Expression[highly expressed] qRT-PCR We detected higher levels of KIAA0125 transcripts in the ameloblastoma group compared to dental follicles (p = 0.042). No 30595406 FAM30A LncRNA Homo sapiens Myelodysplastic Syndromes 176 primary MDS patients Expression(highly expressed) Microarray We found that higher KIAA0125 expression was associated with higher risk MDS, based on the revised International Prognostic Scoring System (IPSS-R), mutations in ASXL1 and NRAS, and predicted poorer overall survival (OS) and leukaemia-free survival (LFS). No 33249572 FAM230B LncRNA Homo sapiens Adenocarcinoma of Lung LA tissues Expression(highly expressed) qRT-PCR FAM230B was highly expressed in LA tissues compared to that in non-tumor samples. In addition, plasma FAM230B was specifically upregulated in LA patients, but not in GRD, COPD and asthma patients. High expression levels of FAM230B in plasma samples were closely correlated with poor survival. Plasma FAM230B was closely correlated with tumor size, but not other clinical factors of LA patients. No 35287554 FAM228B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FAM224A LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction[ A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop] Western Blot//Migration Assay//CCK8//RIP//Luciferase Report Assay//Microarray//Invasion Assay//ChIP Further, qRT-PCR showed that FAM224A was significantly upregulated in glioma tissues and cell lines when compared with NBTs and NHA (Fig. ​(Fig.1c).1c). The present study clarifies that the A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop conducts critical regulatory effects on the malignant progression of glioma cells, which provides a novel molecular target for glioma therapy. No 31186064 FAM219B CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 FAM210A CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 FAM205BP LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FAM197Y5 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FAM181A-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD cell lines and tissues Expression(lower expressed) qRT-PCR FAM181A-AS1 showed significantly low expression in LUAD patients. Low FAM181A-AS1 expression predicted a poorer overall survival (OS) (HR: 0.66; 95% CI: 0.49-0.88; P=0.005) and disease specific survival (DSS) (HR: 0.64; 95% CI: 0.44-0.92; P=0.017) of LUAD patients. There was also an independent correlation between low FAM181A-AS1 expression (HR: 0.547; 95% CI: 0.350-0.857; P=0.008) and OS in LUAD patients. A significant decrease in FAM181A-AS1 expression was observed in LUAD cell lines compared to Beas-2B. Low FAM181A-AS1 expression predicted a poorer overall survival (OS) (HR: 0.66; 95% CI: 0.49-0.88; P=0.005) and disease specific survival (DSS) (HR: 0.64; 95% CI: 0.44-0.92; P=0.017) of LUAD patients. There was also an independent correlation between low FAM181A-AS1 expression (HR: 0.547; 95% CI: 0.350-0.857; P=0.008) and OS in LUAD patients. No 36482943 FAM13A-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FAM129A-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 FALEC LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues,cell lines Interaction[FAL1/DRP1] Flow Cytometry//qRT-PCR//Western Blot "The results in Fig. 3A show that the level of FAL1 was remarkably higher in ESCC tissues than in adja_x0002_cent normal tissues. Consistently, the expression of FAL1 was significantly higher in KYSE450 and EC9706 cells than in nor_x0002_mal esophagus epithelial cell line Het-1A cells (Fig. 3B). In addition, we found that reduced expression of DRP1 in the esophageal cancer cell lines KYSE450 and EC9706 cells was associated with increased expression of FAL1." No 30501006 FALEC LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Expression[highly expressed] qRT-PCR Our findings revealed that the level of expression in the lncRNA-GAS5 and lncRNA-FAL1 genes was significantly upregulated in thyroid cancerous tissues (P < 0.003 and P < 0.040, respectively). The expression of lncRNA-GAS5 and lncRNA-FAL1 revealed a significant association with tumor node metastasis staging (P < 0.042 and P < 0.001, respectively). No 30746742 fantom3_3021401C12 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_4933428M03 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 FCHO2 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 fantom3_6430516O08 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 FCF1P2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FBXO22 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FBXL2-218 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 FBXL19-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute 137 AML patients Expression(lower expressed) qRT-PCR Using receiver operating characteristic curve analysis, we observed that serum FBXL19-AS1 provided the highly diagnostic performance for the detection of AML (AUC = 0.841, < 0.001). We also examined the association between serum FBXL19-AS1 expression and clinicopathological factors, finding that its high expression was associated with French-American-British classification ( = 0.011) and cytogenetics ( = 0.021). Survival assays with the Kaplan-Meier method revealed that the overall survival ( = 0.0088) and disease-free-survival ( = 0.0027) of AML patients with high serum FBXL19-AS1 levels were distinctly shorter compared to those with low serum FBXL19-AS1 levels. No 33474753 FBLN5-206 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[lower expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 FAT4 LncRNA Homo sapiens Breast Neoplasms Breast cancer tissues and adjacent tissues Expression[lower expressed] Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Microarray//Transwell Assay " To summarize, the positive expression rate of FAT4 in breast cancer tissues was significantly lower than that in adjacent tissues (p < 0.05), and the afore_x0002_mentioned results indicated down-regulation of FAT4 in breast cancer." No 30546116 FAS-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[lower expressed] qRT-PCR FAS-AS1 was significantly down-regulated in NSCLC tissues obtained from both males and females subjects compared with the corresponding ANCTs (REx = - 4.12 and - 3.14, P = 0.015 and 0.033 respectively). No 30866866 FAS-AS1 LncRNA Homo sapiens Osteoarthritis osteoarthritis tissues Expression[lower expressed] qRT-PCR The expressions of FAS-AS1, MMP1, and MMP13 in osteoarthritis tissues increased significantly, while COL2A1 presented a low expression. No 29863238 FAS-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder tissues Expression[lower expressed] qRT-PCR PV1 was down-regulated in tumor tissues compared with both ANCTs and normal controls (Expression ratios of 0.48 and 0.14; P values of 0.4 and <0.001 respectively). No 31054930 FAS-AS1 LncRNA Homo sapiens Lupus Erythematosus, Discoid serum Expression[lower expressed] qRT-PCR There was a significant relative increased serum FAS-AS1 (median (IQR) 2.19 (0.13-8.62) and a significant reduced PVT1 (median (IQR) 0.52 (0.01-7.55) in SLE patients compared to controls (P < 0.0001 for FAS-AS1 and = 0.007 for PVT1). No 32614682 FAS-209 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 FARP1 LncRNA Homo sapiens Colorectal Neoplasms cell lines Interaction[stabilizing c-Myc] RNA Pull-Down//Northern Blot//Western Blot//ISH//Co-IP//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//ChIP In this study, we identify a lncRNA, GLCC1, which is significantly upregulated under glucose starvation in CRC cells, supporting cell survival and proliferation by enhancing glycolysis. Mechanistically, GLCC1 stabilizes c-Myc transcriptional factor from ubiquitination by direct interaction with HSP90 chaperon and further specifies the transcriptional modification pattern on c-Myc target genes, such as LDHA, consequently reprogram glycolytic metabolism for CRC proliferation. Clinically, GLCC1 is associated with tumorigenesis, tumor size and predicts poor prognosis. No 31375671 FAR2P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 fantom3_I830062N05 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_F730001C01 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_F630107E09 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_E230007F07 LncRNA Mus musculus acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_E130019F23 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_E030028L20 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_D130059M16 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_D130005M09 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_C130024N02 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_B230105C15 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_A530047B01 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_9930009M05 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_9830118H07 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_9530065C24 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_9230106C11 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 fantom3_9230022E05 LncRNA Homo sapiens acute asthma lung tissue Expression[differently-expression] FISH//RNA-seq//qRT-PCR To obtain a global overview of CD4 T cells in the asthma transcriptome, we constructed and sequenced 6 RNA-Seq libraries, including controls (n = 3) and asthma mice (n = 3). All of the data have been submitted to Sequence Read Archive (SRA +4) with the accession number of PRJNA540404. In total, 134 lncRNAs were significantly altered in expression, including 98 downregulated lncRNAs and 36 upregulated lncRNAs (Figure 2). The top 10 decreased lncRNAs and top 10 increased were listed in Table 2. No 31231429 FOXP1-276 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 FOXP4-AS1 LncRNA Homo sapiens ovarian serous cystadenocarcinoma tumor tissues Expression(highly expressed) qRT-PCR High FOXP4-AS1 expression was significantly correlated with tumor FIGO stage (P = .026). High FOXP4-AS1 expression was significantly correlated with tumor FIGO stage (P = .026).Multivariate survival analysis showed that FOXP4-AS1was an independent prognostic marker for overall survival (OS; hazard ratio [HR]: 0.638; 95% confidence interval [CI]:0.467-0.871; P = .001) and disease-specific survival (DSS; HR: 0.649; CI: 0.476-0.885; P = .006). No 34622876 GNAS LncRNA Homo sapiens COVID-19 mild and severe COVID-19 patients Regulation Bioinformatics Analysis Interestingly we found six lncRNAs (TALAM1, DLEU2, and UICLM CASC18, SNHG20, and GNAS) involved in the protein-coding DEG-lncRNA network; which might be served as potential biomarkers for COVID-19 patients. No 34975833 GAS5 LncRNA Homo sapiens Breast Neoplasms TNBC tissues interaction[miR-196a-5p] qRT-PCR//Luciferase Report Assay Here, we show that levels of the lncRNA, growth arrest-specific transcript 5 (GAS5), are decreased in TNBC tissues, and this down-regulation of GAS5 is associated with an aggressive tumor phenotype in patients, affecting clinical stage, lymph node metastasis and overall survival.These data suggest that GAS5 can suppress TNBC progression by competitively binding miR-196a-5p, therefore GAS5 may be a prognostic biomarker of TNBC. Here, we show that levels of the lncRNA, growth arrest-specific transcript 5 (GAS5), are decreased in TNBC tissues, and this down-regulation of GAS5 is associated with an aggressive tumor phenotype in patients, affecting clinical stage, lymph node metastasis and overall survival. No 29793177 GAS5 LncRNA Homo sapiens Breast Neoplasms blood,BC tissues Mutation[rs145204276 ] qRT-PCR//Luciferase Report Assay//Genotyping The rs145204276 del allele might protect against the development of BC via inducing the promoter activity by binding to transcriptional factor specificity protein 1, and finally resulting in higher levels of GAS5. No 30846409 GAS5 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[lower expressed] Flow Cytometry//qRT-PCR//Transwell Assay GAS5 was downregulated in BC clinical samples compared with adjacent samples and was positively correlated with ULK1/2. No 32705220 GAS5 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung  NSCLC tissues and plasma Expression [lower expressed] qRT-PCR We reported a downregulation of GAS5 expression in NSCLC tissue and plasma, which showed elevation after surgery. Downregulation of GAS5 was associated with poor prognosis of NSCLC patients. No 33969786 GAS5 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression(lower expressed) qRT-PCR//IHC The relative expression of LncRNA GAS5 in NSCLC tissues was substantially less than that of the para-cancerous normal tissues (P<0.05). The positive expression rate of Ki67/EGFR in NSCLC tissues remarkably exceeded that in para-cancerous normal tissues (P<0.05). The relative expression of LncRNA GAS5 was correlated with the degree of tumor differentiation, TNM staging and lymph node metastasis (P<0.05). In addition, the survival of patients with high LncRNA GAS5 expression was obviously superior to those with low LncRNA GAS5 expression (P<0.05), patients with negative Ki67 had superior survival than those with positive Ki67 (P<0.05), and patients with negative EGFR had increased survival over those with positive EGFR (P<0.05). No 34150073 GAS5 LncRNA Homo sapiens Colorectal Neoplasms Cell lines（DLD1, LOVO, SW480, SW620, LS174T, HCT116, RKO, and HT29 ） Regulation[GAS5-YAP-YTHDF3 axis] RNA Pull-Down//ISH//MeRIP//RIP//FISH//IHC//ChIP GAS5 directly interacts with WW domain of YAP to facilitate translocation of endogenous YAP from the nucleus to the cytoplasm and promotes phosphorylation and subsequently ubiquitin-mediated degradation of YAP to inhibit CRC progression in vitro and in vivo. Notably, we demonstrate the m6A reader YTHDF3 not only a novel target of YAP but also a key player in YAP signaling by facilitating m6A-modified lncRNA GAS5 degradation, which profile a new insight into CRC progression. Clinically, lncRNA GAS5 expressions is negatively correlated with YAP and YTHDF3 protein levels in tumors from CRC patients. No 31619268 GAS5 LncRNA Homo sapiens Colorectal Neoplasms CRC tisssues Mutation[rs55829688] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Genotyping Results showed that subjects carrying the rs55829688 CT/TT genotypes had a significantly higher risk of CRC when compared with the CC genotype. Further qPCR assay confirmed that the CRC tissues with rs55829688 CT/TT genotypes had a higher GAS5 mRNA expression level. The dual-luciferase assay, qPCR and EMSA assay revealed that rs55829688 T>C polymorphism could decrease the expression level of GAS5 by impacting the binding ability of the transcription factor Yin Yang-1 (YY1) to the GAS5 promoter region. The expression of apoptosis-related proteins were detected by Western blot. Further, flow cytometry, migration, and invasion experiments showed that GAS5 repressed apoptosis and increased invasion and migration capability of CRC cells. Taken together, our findings provided evidence that the rs55829688 variant in the GAS5 promoter was associated with the risk of CRC and decreased expression of GAS5 by affecting the binding affinity of the transcription factors YY1 to GAS5. No 30902880 GAS5 LncRNA Homo sapiens Thyroid Cancer, Papillary PTC tissues Expression[highly expressed] qRT-PCR Our findings revealed that the level of expression in the lncRNA-GAS5 and lncRNA-FAL1 genes was significantly upregulated in thyroid cancerous tissues (P < 0.003 and P < 0.040, respectively). The expression of lncRNA-GAS5 and lncRNA-FAL1 revealed a significant association with tumor node metastasis staging (P < 0.042 and P < 0.001, respectively). No 30746742 GAS5 LncRNA Homo sapiens Carcinoma, Renal Cell Southern Chinese Population Mutation(rs145204276 ) In Vivo Experiment//RNA Pull-Down//Western Blot//Co-IP//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay There were significant differences in the GAS5 rs145204276 polymorphism genotype and allele frequencies between the RCC patients and controls (adjusted OR = 0.73, 95% CI = 0.61- 0.87, P = 1.8×10-3). When the study participants were stratified based on age, sex, BMI index, and smoking and drinking history, we found that the rs145204276 del allele was associated with a reduced risk for RCC in nondrinkers (P = 3.3×10-3), nonsmokers (P = 3.3×10-3), females (P = 3.8×10-3), and those who were less than 60 years old (P = 3.3×10-3). When the study participants were stratified based on age, sex, BMI index, and smoking and drinking history, we found that the rs145204276 del allele was associated with a reduced risk for RCC in nondrinkers (P = 3.3×10-3), nonsmokers (P = 3.3×10-3), females (P = 3.8×10-3), and those who were less than 60 years old (P = 3.3×10-3). No 35210817 GAS5 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cell lines Interaction[targeting TP53INP1 ] CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay Firstly, our results showed that miR-1323 promoted proliferation and invasion, and inhibited apoptosis of HCC cells. Secondly, we found that TP53INP1 was a direct target of miR-1323 and could reverse the effects of miR-1323 on proliferation, invasion and apoptosis of HCC cells. Thirdly, our results showed that long non-coding RNA (lncRNA) GAS5 and miR-1323 could interact with each other and affect biological processes of HCC cells. Furthermore, we identified the negative correlations between miR-1323 and TP53INP1, and between miR-1323 and GAS5 in tumor tissues of patients with HCC. No 31190897 GAS5 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR The expression level of lncRNA NEAT1, H19, MALAT1, HOTAIR, DANCR, UCA1, and BCAR4 were significantly decreased, compared with that in adjacent noncancerous tissues (all P <.05). The expression level of lncRNA GAS5 was statistically significantly increased (P <.05). For the quantitative polymerase chain reaction (qPCR) assay, 8 kinds of lncRNAs were detected as a result of the GeXP assay. No 30423146 GAS5 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Expression[lower expressed] qRT-PCR The results demonstrated that GAS5 was significantly downregulated in HCC tissues and cells, especially in CDDP-resistant HCC tissues and cells. No 32213078 GAS5 LncRNA Homo sapiens Carcinoma, Hepatocellular PBMC-CD4+ T cells and tumor tissues Mutation(rs145204276) Flow Cytometry//qRT-PCR The lncRNA-GAS5 level decreased significantly in PBMC-CD4+ T cells and tumor tissues compared with the healthy controls and corresponding adjacent non-tumor tissues. LncRNA-GAS5 expression in PBMC-CD4+ T cells was negatively associated with IL-6, IL-17, and the RORγT/CD3 ratio (an indicator of Th17 polarization). LncRNA-GAS5 expression and its promoter region rs145204276 polymorphism are prognostic biomarkers that can predict postoperative pain of patients with HCC undergoing hepatectomy. The patients with Del/Del genotype showed significantly higher lncRNA-GAS5 expression in PBMC-CD4+ T cells, lower postoperative pain scores, and better overall survival. No 36585876 GAS5 LncRNA Homo sapiens Ovarian Neoplasms Expression[lower expressed] Western Blot//RIP//MTT//Luciferase Report Assay//PCR Data from TCGA database showed that lncRNA GAS5 is downregulated in OV cancer and its expression is negatively correlated with GDF15 expression. No 31314588 GAS5 LncRNA Homo sapiens Urinary Bladder Neoplasms Mutation[rs2067079 ;rs6790] Genotyping n the present project, we genotyped two putative functional SNPs (rs2067079 and rs6790) in 122 bladder cancer patients and 150 age- and sex-matched healthy subjects. The rs2067079 was associated risk of bladder cancer in recessive inheritance model (TT vs.CC + CT: OR (95% Confidence interval (CI)) = 2.67 (1.27-5.62), adjusted P value = 0.02). The T G haplotype (rs2067079 and rs6790) increased the risk of bladder cancer in the assessed population (OR (95% CI) = 1.73 (1.18-2.56), adjusted P value = 0.02). No 31250374 GAS5 LncRNA Homo sapiens Leukemia, Myeloid, Acute Younger AML Patients Interaction(miR-222 ) RIP//IP//IF Our results showed that GAS5 expression level in AML patients was lower compared to healthy controls. In the AML-NK group patients had higher expression of miR-222 compared to healthy controls. This is the first study focused on examining the GAS5 and miR-222 expression pattern in AML patients. Lower GAS5 expression on diagnosis was related to an adverse prognosis. No 35054253 GAS5 LncRNA Homo sapiens Leukemia, Myeloid, Acute THP-1 cells Regulation(Acute Myeloid Leukemia) qRT-PCR//EdU Staining//Western Blot The si-RNA significantly inhibited the expression of lncRNA GAS5 in THP-1 cells. Compared with the si-NC group, the difference in cell apoptosis between lncRNA GAS5 and Nrf2 groups was significant (P < 0.05). Compared with the lncRNA GAS5 group, the number of apoptotic cells in the lncRNA GAS5+Nrf2 group significantly reduced (P < 0.05). Compared with the si-NC group, the differences in the levels of four proteins between lncRNA GAS5 and Nrf2 groups were significant (P < 0.05). In lncRNA GAS5+Nrf2 and lncRNA GAS5 groups, PD-L1 expression increased, while the expression of STAT3, AKT, and MMP9 decreased. No 36061350 GAS5 LncRNA Homo sapiens Glioma cell lines Interaction[PTEN/PI3K/AKT and MEK/ERK] CCK8//qRT-PCR//Western Blot GAS5 inhibited proliferation and motile behaviors, and fortified apoptosis. As for the viability and motile activities, the property of GAS5 was reversed in miR-10b-replenished U251 and A172 cells, while maintained in miR-10b-deficient cells. Additionally, GAS5-induced apoptosis was abolished by miR-10b overexpression while fortified by miR-10b silence. Besides, GAS5 negatively modulated Sirt1 via miR-10b. Moreover, Sirt1 negatively modulated PTEN and positively mediated the abovementioned regulators. GAS5 represses the process of glioma cells by decreasing miR-10b, which as accompanied by Sirt1 silence-induced inactivation of PTEN/PI3K/AKT and MEK/ERK cascades. No 31889362 GAS5 LncRNA Homo sapiens Glioma cell lines Expression[lower expressed] qRT-PCR In the current study, the expression of GAS5 was decreased in glioma cell lines. No 30317677 GAS5 LncRNA Homo sapiens Atrial Fibrillation blood Expression[lower expressed] qRT-PCR Circulating GAS5 expression was significantly down-regulated in AF patients. No 32929817 GAS5 LncRNA Homo sapiens Adenocarcinoma of Lung GASS gene Mutation(GAS5 SNP rs145204276 variant) qRT-PCR In conclusion, these data indicate that the GAS5 SNP rs145204276 variant may help predict tumor stage, lymph node metastasis and distal metastases in patients with EGFR wild type lung adenocarcinoma. The GAS5 SNP rs145204276 Ins/Del + Del/Del illustrated a higher distribution with an advanced tumor stage (p = 0.030), larger tumor T status (p = 0.019), positive lymph node status (p = 0.014) and distal metastases (p = 0.011) in the EGFR wild type group. In the subgroup analysis of the EGFR wild type population, the presence of GAS5 SNP rs145204276 Ins/Del + Del/Del was correlated to an advanced tumor stage (p = 0.014) and distal metastases (p = 0.020) in non-smokers. No 36011604 GAS5 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung exosomes Expression[lower expressed] qRT-PCR Previous studies have found that long noncoding RNA growth arrest-specific transcript 5 (GAS5) is essential to cancer progression. However, the expression and diagnostic value of GAS5 in exosomes (Exo-GAS5) remain unclear.Our data indicated that the Exo-GAS5 was downregulated in patients with NSCLC compared with healthy controls ( p < 0.001). No 31032916 GAS5 LncRNA Homo sapiens Alzheimer Disease patients with AD Expression(highly expressed) qRT-PCR The levels of GAS5 were significantly upregulated in patients with AD compared with those in controls and were negatively correlated with MMSE score. Total hippocampal volume was positively correlated with MMSE score and negatively correlated with GAS5 expression in patients with AD. No 35592641 GAS5 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck LSCC cell lines Regulation(p53 ) In Vivo Experiment//ChIP//Western Blot//Co-IP//Colony Formation Assay//CCK8//Flow Cytometry//FISH//RIP//IHC//IF LSCC cell lines presented with upregulated expression of YY1, downregulated GAS5 expression, and decreased p53 stability. YY1 inhibited the expression of GAS5, which in turn recruited p300 and bound to p53, thus stabilizing it. No 34497757 GAS5 LncRNA Homo sapiens Prostatic Neoplasms Mutation[rs145204276 ] qRT-PCR In conclusion, the rs145204276 polymorphic genotype of GAS5 can predict the risk of lymph node metastasis. This is the first study to report the correlation between GAS5 gene polymorphism and prostate cancer prognosis. No 31673232 GAS5 LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 GAS5 LncRNA Homo sapiens Multiple Sclerosis blood Mutation[rs55829688] PCR//Genotyping The purpose of our study was to evaluate the association between MS and polymorphisms within NR3C1 (rs6189/6190, rs56149945, rs41423247) and GAS5 (rs55829688) genes in 300 relapsing-remitting MS patients and 300 healthy subjects.Results: We demonstrated significant differences in distribution of genotype, allele and haplotype frequencies of rs6189, rs41423247 and rs55829688 between the study groups. No 31724909 GAS5 LncRNA Homo sapiens Multiple Sclerosis blood Mutation[rs2067079 ] Genotyping In the current study, we genotyped two possibly functional GAS5 polymorphisms (rs2067079 and rs6790) in 810 individuals including 410 MS patients and 400 age and sex-matched healthy subjects. There was a significant over-representation of the rs2067079 T allele in MS patients compared with healthy individuals (OR (95% CI) = 1.38 (1.12-1.71), adjusted P value = 0.008). This SNP was associated with MS risk in co-dominant and recessive models (OR (95% CI) = 2.70 (1.54-4.76), adjusted P value = 0.003; OR (95% CI) = 2.58 (1.5-4.42), adjusted P value = 7.9E-4 respectively). The rs6790 was not associated with MS risk in any inheritance models. No 30790644 GAS5 LncRNA Homo sapiens Breast Neoplasms blood Expression[lower expressed] qRT-PCR Our results revealed a significant down-regulation of expression of GAS5 and a significant up_x0002_regulation of SOX2OT expression levels in NSCLC patients when compared to controls . No 31077615 GAS6-AS LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] qRT-PCR On the other hand, expression of GAS6-AS1 was down-regulated in breast tumor tissues compared with controls (Ratio of Mean Expressions = 0.37, P value = 4.26E-03). No 33359886 GAS5 LncRNA Homo sapiens Liver Neoplasms HCC tissues,cell lines Expression[lower expressed] qRT-PCR//MTT//Luciferase Report Assay We found that GAS5 was downregulated in HCC cell lines and tumor tissues. No 31705194 GAS6-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Expression [lower expressed] Survival Analysis In this study, autophagy-related mRNAs-lncRNAs were screened from lung adenocarcinoma and a co-expression network of autophagy-related mRNAs-lncRNAs was constructed by using The Cancer Genome Atlas (TCGA). The univariate and multivariate Cox proportional hazard analyses were used to evaluate the prognostic value of the autophagy-related lncRNAs and finally obtained a survival model composed of 11 autophagy-related lncRNAs. No 33987935 GMDS-DT LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and corresponding adjacent normal liver tissues Expression[Expression[lower expressed]-expression] qRT-PCR//Microarray The results of qRT-PCR analyzed by paired t-test indicated that the expression of GMDS-DT in HCC tissue was significantly lower than that of the corresponding adjacent normal liver tissue (P<0.001; Figure 3B). "Kaplan-Meier curves of the low and high expression groExpression[Expression[up-expression]-expression]s were drawn, and the log-rank test was performed. The results showed that patients in the low expression groExpression[Expression[up-expression]-expression] had significantly poorer prognosis after hepatectomy, manifested as significantly shorter postoperative disease-free survival (P=0.028) and overall survival (P=0.003; Figure 4A, 4B). " No 31423008 Gm4419 LncRNA Homo sapiens Myocardial Reperfusion Injury myocardial tissues and hypoxia/reoxygenation H9C2 cells regulation[miR-682/TRAF3 Axis] Flow Cytometry//qRT-PCR//CCK8//Luciferase Report Assay//ELISA In the present study, quantitative real-time PCR showed that lncRNA Gm4419 was highly upregulated in ischemia/reperfusion myocardial tissues and hypoxia/reoxygenation H9C2 cells, whereas miR-682 was downregulated.Therefore, the Gm4419/miR-682/TRAF3 axis may be an important regulatory mechanism in myocardial ischemia/reperfusion injury. No 32590403 Gm16793-201 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[lower expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 14. No 30974198 Gm12610 LncRNA Mus musculus Uremia mice with uremia Expression(lower expressed) TUNEL//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay ANRIL down-regulation or miR-181b up-regulation can increase the weight of mice with uremia, as well as the expressions of p62 and miR-181b, and reduce the content of serum creatinine and urea nitrogen, the damage of kidney and myocardial tissues, the number of apoptotic cells in myocardial tissues, as well as the expressions of ANRIL, ATG5, Beclin1, and LC3. No 34469488 Gm12431 LncRNA Mus musculus Atherosclerosis aortic tissue Expression[lower expressed] qRT-PCR//Microarray The top fve up-regulated and top fve down-regulated lncR_x0002_NAs are listed in Table 3. No 31446617 Gm10435-201 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[lower expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 11. No 30974198 GLUL-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 GLIS3-216 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 GLG1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 GINS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 GIHCG LncRNA Homo sapiens Colorectal Neoplasms CRC tissues, cell lines Expression[highly expressed] qRT-PCR GIHCG was overexpressed in seven CRC cell lines and 110 CRC tissues. High GIHCG expression was correlated with lymphovascular invasion, lymph node metastasis, distant metastasis and advanced TNM stages. Moreover, patients with high GIHCG expression had much poorer OS and PFS rates. No 30799935 GIHCG LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR GIHCG was highly expressed in HCC tissues compared with normal liver tissues. In addition, high GIHCG expression was significantly correlated with inferior clinicopathological characteristics and shorter survival times. High GIHCG expression was an independent prognostic factor for overall survival and disease-free survival in the HCC cohort in our center and in the TCGA-LIHC cohort. No 33209037 GHRLOS LncRNA Homo sapiens Stomach Neoplasms 50 GC patients and 50 healthy controls Expression(lower expressed) qRT-PCR On the other hand, SEC13, GHRL, and lncRNA GHRLOS expression were significantly downregulated in GC patients (P = < 0.001, 0.025, < 0.001 respectively) and had significant positive correlations with each other (P < 0.001). No 35449150 GHET1 LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis The combined results indicate that an elevated GHET1 expression level is significantly associated with poor overall survival (OS) (HR = 2.40, 95% CI: 1.87-3.08, p < 0.001) and tumor progression (III/IV vs. I/II: HR = 1.80, 95% CI: 1.48-2.18, p < 0.001) in multiple cancers. The elevated GHET1 expression was also associated with lymph node metastasis (LNM) (HR = 2.44, 95% CI: 1.86-3.20, p < 0.001) in Chinese cancer patients. No 31885739 GHET1 LncRNA Homo sapiens Neoplasms Expression[highly expressed] Meta-analysis The result showed that GHET1 expression was significantly associated with OS (hazard ratio [HR] = 2.23; 95% CI, 1.86-2.67; P < 0.0001), including digestive system tumor (HR = 2.17; 95% CI, 1.63-2.89; P < 0.0001). Moreover, high GHET1 expression was related to tumor size (odds ratio [OR] = 2.15, 95% CI: 1.57-2.94; P < 0.00001), TNM stage (Ⅲ+Ⅳ vs.Ⅰ+Ⅱ; OR = 4.02, 95% CI:3.06-5.28; P < 0.00001), lymph node metastasis (Yes vs. No; OR = 3.55, 95% CI:2.54-4.95; P < 0.00001), differentiation (poor vs. well or moderate; OR = 1.72, 95% CI:1.22-2.42; P = 0.002), vascular invasion (Yes vs. No; OR = 3.03, 95% CI:1.80-5.12; P = 0.00001). Also, we found that high expression of GHET1 has a significant relationship with analysis method and sample size. It almost higher in different human cancers. No 32653201 GHET1 LncRNA Homo sapiens Glioma cell lines Interaction[down-regulation of miR-216a] CCK8//qRT-PCR//Western Blot The viability, migration and invasion of U251 cells were promoted by GHET1 overexpression. The pro-cell cycle genes including Cyclin D1, CDK4 and CDK6, and the pro-metastasis genes including MMP-9 and Vimentin were up-regulated after GHET1 was overexpressed. MiR-216a was found to be down-regulated by GHET1 overexpression, and it was involved in the effects of GHET1 on U251 cells. GHET1 might promote U251 cells by down-regulating miR-216a. Finally, we found that GHET1 overexpression activated the JAK2/STAT3 and p53/survivin signaling pathways by down-regulating miR-216a. No 30840282 GHET1 LncRNA Homo sapiens Solid Tumors Expression[highly expressed] Meta-analysis Overexpression of GHET1 may be a convincing adverse prognostic factor that contributes to the clinical decision-making procedure of cancer treatment. No 32658414 GGTA2P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 GFOD2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 GEMIN8P4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 GCSHP3 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)6) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 GBCDRlnc1 LncRNA Homo sapiens Gallbladder Neoplasms gallbladder cancer tissues Expression[highly expressed] RNA Pull-Down//Western Blot Furthermore, we discovered that GBCDRlnc1 is upregulated in gallbladder cancer tissues. No 30953511 GBAP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 GATA3-AS1 LncRNA Homo sapiens Breast Neoplasms cancerous tissues Interaction(miR-495-3p/CENPU axis) qRT-PCR//Cell Viability Assay Combination of the results from expression, survival, correlation analysis and functional experiments analysis demonstrated the link between lncRNA GATA3-AS1/miR-495-3p/CENPU axis and prognosis of breast cancer. No 33902008 GATA2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung cell lines Interaction[GATA2] qRT-PCR//Colony Formation Assay//RIP//Western Blot Here we found a long non-coding RNA, GATA2-AS1, repressing NSCLC cells proliferation via regulating GATA2. GATA2-AS1 gene is located at antisense strand of GATA2 on chromosome while GATA2-AS1 RNA interacts with GATA1 protein at promoter region of GATA2 and then inhibits its transcription. Moreover, GATA2-AS1 is transcriptionally repressed by MYC in NSCLC cells. No 31607132 GAS8-AS1 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[highly expressed] qRT-PCR Although the expression of GAS8-AS1 was higher in tumor tissues compared to ANCTs (Expression ratio=2.15), it did not reach the level of significance (p=0.12). No 31749921 GAS8-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR//RNA Pull-Down//RIP//ChIP We found that expression of GAS8-AS1 or GAS8 is significantly decreased in HCC tissues and is associated with a poor prognosis among HCC patients. No 30228180 GAS8-AS1 LncRNA Homo sapiens Osteosarcoma cancer tissues regulation[lncRNA UCA1 ] qRT-PCR//Transwell Assay The results showed that GAS8-AS1 was downregulated, while UCA1 was upregulate in cancer tissues in comparison to adjacent non-cancer tissues of OS patients. No 32013985 GAS8-AS1 LncRNA Homo sapiens Pancreatic Neoplasms plasma, PC cell Interaction(MiR-1179) qRT-PCR//Transfection//Invasion Assay The study showed that plasma GAS8-AS1 was lower in PC patients than in healthy controls.Plasma miR-1179 levels were also significantly lower in PC patients than in healthy controls and were positively correlated with plasma GAS8-AS1 levels in PC patients but not healthy controls. GAS8-AS1 overexpression upregulated miR-1179, and MiR-1179 overexpression increased GAS8-AS1 level. Overexpression of both GAS8-AS1 and miR-1179 inhibited PC cell migration and invasion. Downregulation of plasma GAS8-AS1 distinguished early-stage PC patients from healthy controls. Patients with low GAS8-AS1 plasma levels showed a significantly lower 5-year overall survival rate. No 35695668 GAS5 LncRNA Homo sapiens Melanoma malignant melanoma tissues Interaction[G6PD ] FISH//MTT//RIP//Western Blot Analysis of clinical samples from MM patients showed that the rate of reduced GAS5 expression, relative to that in adjacent noncancerous tissues, was significantly lower for tumors from patients with advanced disease (76.6%, P < 0.001), as evidenced by larger tumor size, higher TNM stage, and higher incidences of ulceration and metastasis (P < 0.001 for all). Cell culture experiments showed that siRNA-mediated knockdown of GAS5 increased the viability of A375-GAS5si cells. Flow cytometry and western blotting showed that GAS5 knockdown increased MM cell proliferation by inducing G1/S cell cycle progression through increases in Cyclin D1, CDK4, and p27 expression (P < 0.05 for all) and by inhibiting apoptosis through an increase in Bcl-2 expression (P < 0.001). Knockdown of GAS5 also increased levels of superoxide anion (P < 0.01), NADP(P < 0.001), and oxidized glutathiones (P < 0.01) through increases in NOX4 expression (P < 0.001), G6PD expression (P < 0.01), and NOX activity (P < 0.05), and RNA co-immunoprecipitation showed that GAS5 induced these changes through a physical interaction between GAS5 and the G6PD protein. + Analysis of clinical samples from MM patients showed that the rate of reduced GAS5 expression, relative to that in adjacent noncancerous tissues, was significantly lower for tumors from patients with advanced disease (76.6%, P < 0.001), as evidenced by larger tumor size, higher TNM stage, and higher incidences of ulceration and metastasis (P < 0.001 for all). No 31866421 GAS5 LncRNA Homo sapiens Ischemic Stroke patients with AIS Expression(highly expressed) qRT-PCR//ELISA Lnc-GAS5 expression levels were higher in patients with AIS than in the controls (p < 0.001), and it had the potential to discriminate the controls from patients with AIS (area under the curve: 0.893, 95% confidence interval: 0.849-0.938).In patients with AIS, elevated lnc-GAS5 levels were positively correlated with NIHSS score (r = 0.397, p < 0.001), diabetes mellitus (p = 0.046), and higher levels of tumor necrosis factor alpha (TNF-α; r = 0.374, p < 0.001), interleukin-6 (IL-6; r = 0.223, p < 0.001), and interleukin-17A (IL-17A; r = 0.222, p = 0.015). The expression levels of lnc-GAS5 were also negatively correlated with the levels of interleukin-10 (IL-10; r = -0.350, p < 0.001) and RFS (p = 0.036). No 34921461 FOXP4-AS1 LncRNA Homo sapiens Nasopharyngeal carcinoma nasopharyngeal carcinoma patients Expression(highly expressed) qRT-PCR In this study, we observed that the levels of FOXP4-AS1 were significantly upregulated in nasopharyngeal carcinoma patients compared to healthy volunteers. Besides, the expression of FOXP4-AS1 was closely associated with T stage, lymph node metastasis, and clinical stage. Meanwhile, ROC analysis found that FOXP4-AS1 had diagnostic values to distinguish tumor patients from healthy volunteers. Furthermore, patients with high FOXP4-AS1 expression level had poorer OS and PFS than those with low FOXP4-AS1 expression. No 33442523 GALNT7 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 GALNT16-206 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 GALNT10-209 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 GACAT3 LncRNA Homo sapiens Breast Neoplasms cell lines Interaction[down- regulating Caspase 9 and up-regulating Bcl-2] BrdU//qRT-PCR//Tunel The expression of LncRNA GACAT3 was increased in breast cancer tissues and cell lines compared to paracancer tissues and normal cells.Down-regulation of LncRNA GACAT3 increased the expression of miR-497, and miR-497 mimics reduced the luciferase of LncRNA GACAT3. Increased LrcRNA GACAT3 in breast cancer cells could downregulate the expression of miR-497, down-regulate Capsase 9 and up-regulate Bcl-2 to promote proliferation and anti-apoptosis of breast cancer cells. Compared with the low expression group, patients with high expression had poorer MRI diffusionweighted imaging and lower overall survival. No 31983109 GACAT3 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues interaction[LINC00152,miR-103] qRT-PCR//Luciferase Report Assay GACAT3 was identified to be highly expressed in CRC tissues and associated with cell proliferation. Furthermore, we demonstrated that GACAT3 acted as a competing endogenous RNA of LINC00152 and they were both regulated by miR-103 Moreover, analysis of clinicopathological characteristics revealed that GACAT3 and LINC00152 were positively correlated with the depth of invasion, TNM stage, lymph node metastasis, and CA19-9 level. No 32462718 GACAT3 LncRNA Homo sapiens Glioma glioma tissues and cell lines Interaction[sponging miR-135a] qRT-PCR//Luciferase Report Assay//RIP In the present study, we showed that GACAT3 is upregulated in glioma tissues and cell lines. Further, nicotinamide phosphoribosyl transferase (NAMPT) was confirmed as a target gene of miR-135a by a series of gain- and loss-of-function assays. Overall, the present study was the first to show that GACAT3 regulates the expression of NAMPT to promote glioma progression by sponging miR-135a. These findings provide a promising therapy strategy for glioma. No 30536379 GABRG3-AS1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 GABPB1-AS1 LncRNA Homo sapiens Sjogren's Syndrome PBMCs of 30 patients with pSS and 15 healthy persons Expression(highly expressed) qRT-PCR//Bioinformatics Analysis Real-time PCR revealed that GABPB1-AS1 and PSMA3-AS1 were significantly up-regulated 3.0- and 1.4-fold in the pSS group, respectively. The GABPB1-AS1 expression level was positively correlated with the percentage of B cells and IgG levels. No 34284720 GABPB1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC cells and HCC tissues Interaction(miR-93/PEDF) In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Cell Proliferation Assay It was demonstrated that GABPB1-IT1 can interact with miR-93 in HCC cells, while overexpression of GABPB1-IT1 and miR-93 in HCC cells did not affect the expression of each other. GABPB1-IT1 was downregulated in HCC tissues compared with paired non-tumor tissues and predicted poor survival. Notably, overexpression of GABPB1-IT1 in HCC cells led to upregulation of pigment epithelium-derived factor (PEDF), a target of miR-93. GABPB1-IT1 was downregulated in HCC tissues compared with paired non-tumor tissues and predicted poor survival. No 33664823 GAA LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 G21551 LncRNA Homo sapiens Glomerulonephritis, IGA plasma Expression[lower expressed] qRT-PCR lncRNA-G21551 was significantly down-regulated in IgAN patients. No 32234013 G004246 LncRNA Homo sapiens COVID-19 39 COVID-19 patients Regulation qRT-PCR//Microarray All patients with COVID-19 displayed lymphopenia, especially in T cells, and hyper-inflammatory responses, including IL-6 and TNF-α. Four immune-related lncRNAs in COVID-19 were found and further validated, including AC136475.9, CATG00000032642.1, G004246, and XLOC_013290. No 35573725 FZD6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FUS LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FUNDC2P2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FUNDC1 CircRNA Homo sapiens Ischemic Stroke peripheral blood Expression(highly expressed) IP//qPCR//PCR Compared to the controls, the levels of three circRNAs were significantly increased in three subgroups of patients, including large artery atherosclerosis (LAA) stroke, small artery occlusion (SAO) stroke, and cardioembolism (CE) stroke (all P < 0.001).Among, LAA stroke patients had higher levels of circular RNA FUNDC1 (circFUNDC1) compared to SAO stroke patients (P = 0.015). CircFUNDC1 levels were positively correlated with National Institutes of Health Stroke Scale (NIHSS) scores on the 7th day only in LAA patients (P = 0.048, r = 0.226). It should be noted that the levels of circFUNDC1 in patients with early neurological deterioration (END), admitted within 24 h after onset, were significantly higher than those without END (P = 0.013). In addition, circFUNDC1 levels positively correlated with baseline NIHSS scores (P = 0.016, r = 0.203) or the 7th day NIHSS scores (P = 0.001, r = 0.289) in patients within 24 h after onset. Importantly, after 18 months of follow-up, a significant difference was observed on survival Kaplan-Meier curves (P = 0.042) between AIS patients with low (below cut-off) or high circFUNDC1 levels (above cut-off). Compared to the controls, the levels of three circRNAs were significantly increased in three subgroups of patients, including large artery atherosclerosis (LAA) stroke, small artery occlusion (SAO) stroke, and cardioembolism (CE) stroke (all P < 0.001).Among, LAA stroke patients had higher levels of circular RNA FUNDC1 (circFUNDC1) compared to SAO stroke patients (P = 0.015). CircFUNDC1 levels were positively correlated with National Institutes of Health Stroke Scale (NIHSS) scores on the 7th day only in LAA patients (P = 0.048, r = 0.226). It should be noted that the levels of circFUNDC1 in patients with early neurological deterioration (END), admitted within 24 h after onset, were significantly higher than those without END (P = 0.013). In addition, circFUNDC1 levels positively correlated with baseline NIHSS scores (P = 0.016, r = 0.203) or the 7th day NIHSS scores (P = 0.001, r = 0.289) in patients within 24 h after onset. Importantly, after 18 months of follow-up, a significant difference was observed on survival Kaplan-Meier curves (P = 0.042) between AIS patients with low (below cut-off) or high circFUNDC1 levels (above cut-off). No 35720103 FUBP1-205 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 FTX-262 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 FTX-239 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 FTX LncRNA Homo sapiens Colonic Neoplasms HCT116 cells Regulation qRT-PCR Our results indicate that the alteration of Ftx expression induces proteomic changes in highly metastatic HCT116 cells, suggesting that Ftx and its downstream molecules and signaling pathways could be potential diagnostic biomarkers and therapeutic targets for metastatic CRC. No 35490216 FTX LncRNA Homo sapiens Glioma glioma tissues Expression[highly expressed] qRT-PCR FTX levels were significantly up-regulated in glioma specimens compared to the paired non-neoplasm specimens (p < 0.01). Furthermore, high FTX expression in neoplasm tissues was dramatically associated with World Health Organization grade (p = 0.001) and Karnofsky Performance Score (p = 0.009). Kaplan-Meier assays with 187 patients revealed that patients with high level of FTX expression displayed poorer OS (p = 0.002) and PFS (p = 0.000). Subsequently, multivariable Cox regression analysis identified FTX expression as an independent prognostic factor of unfavorable survivals in glioma (OS: p = 0.001; PFS: p = 0.002). No 32476208 FTX LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 670 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 FTX LncRNA Homo sapiens Thyroid cancer, medullary medullary thyroid tumor tissues Expression [highly expressed] qRT-PCR Here we have tested three up-regulated (RMST, FTX, IPW) and one down-regulated (RMRP) lncRNAs in our samples (formalin fixed paraffin embedded tissues from twenty-one MEN2 and ten sMTC patients) by RT-qPCR analysis. No 33407723 FTLP2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)104) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 FTH1P3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 FTH1P22 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1062 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 FSTL5 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 FRGCA LncRNA Homo sapiens Colonic Neoplasms COAD tissues Expression[highly expressed] qRT-PCR lncRNA FRGCA was highly expressed in tumor tissues of COAD and demonstrated diagnostic value (area under curve = 0.763, P < .0001). Prognostic significance analysis indicated that lncRNA FRGCA had prognostic value in COAD [adjusted P < .001, hazard ratio (HR) = 0.444, 95% confidence interval (95% CI) = 0.288-0.685] and high expression of lncRNA FRGCA indicated better survival in COAD. No 33126318 FOXP4-AS1-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 FOXP4-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR The HCC samples had significantly higher levels of FOXP4-AS1 compared with the control (P=0.001). No 31695417 GALNT2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 GALNTL5 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 GAS5 LncRNA Homo sapiens Inflammatory Bowel Diseases inflamed biopsies Interaction[MMPs] Immunoblotting//qPCR Real-time PCR results demonstrated a downregulation of GAS5 and an upregulation of both MMPs in inflamed tissues. In vitro data confirmed the trend observed in patients for the three genes: The stimulation with LPS promoted a downregulation of GAS5 while an increase of MMPs was observed. Overexpression experiments showed that higher levels of GAS5 lead to a decrease of both enzymes. No 31652976 GAPDHP25 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)20) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 GAS5 LncRNA Homo sapiens Diabetes, Gestational peripheral blood of pregnant women with GDM Expression(lower expressed) RIP//IP The lncRNA GAS5 was downregulated in the peripheral blood of pregnant women with GDM compared with normal pregnant women. No 35178132 GAS5 LncRNA Homo sapiens Prostatitis prostatitis tissues Interaction[COX-2 ] RIP//MTT//Western Blot The expression of GAS5 was decreased, while COX-2 was increased in prostatitis tissues and in LPS-induced RWPE-1 cells. The overexpression of GAS5 suppressed the protein level of COX-2, and inhibited cell proliferation of LPS-induced RWPE-1 cells and HPECs, which was rescued by the co-transfection with pcDNA-GAS5 and pcDNA-COX-2. GAS5 was confirmed to promote the ubiquitination of COX-2, and the in vivo GAS5-overexpressed CNP rat model decreased the motor scores, the volume of prostate tissues, the average number of inflammatory cells, prostatic proliferation, and COX-2 expression. No 30892130 GAS5 LncRNA Homo sapiens Klinefelter Syndrome blood Expression[highly expressed] qRT-PCR//RNA-seq NGS results showed a significantly lncRNAGAS5up-regulation by 5.171-fold in patients with KS. Theresults of qRT-PCR confirmed the NGS data. No 30612561 GAS5 LncRNA Homo sapiens Arthritis, Rheumatoid blood Interaction[downregulates IL-18] qRT-PCR//ELISA In the present study, we found that plasma GAS5 was downregulated, while IL-18 was upregulated in RA patients than in healthy controls.A significant and inverse correlation between GAS5 and IL-18 was found in RA patients but not in healthy controls. IL-18 treatment did not significantly alter the expression of GAS5 in fibroblast-like synoviocytes, while GAS5 overexpression led to the inhibited expression of IL-18. GAS5 overexpression also resulted in the promoted apoptosis of fibroblast-like synoviocytes. No 31372853 GAS5 LncRNA Homo sapiens Arthritis, Rheumatoid blood Expression[highly expressed] qRT-PCR The results indicate that T cells of RA patients display increased levels of GAS5 (3.31-fold, p = 0.007), RMRP (2.43-fold, p = 0.02), and THRIL (2.14-fold, p = 0.03) lncRNAs compared with those of controls. No 31346885 GAS5 LncRNA Homo sapiens Arthritis, Rheumatoid blood regulation[ AMPK pathway] qRT-PCR//Western Blot GAS5 was down-regulated in RA PBMCs, and consequently serves as a potential diagnostic marker for RA (sensitivity, 90%; specificity, 80%; area under the curve, 0.89).GAS5 activated the AMPK pathway, while it negatively regulated the expression of cytokines IL-6 and IL-17. GAS5 was down-regulated in RA PBMCs, and consequently serves as a potential diagnostic marker for RA (sensitivity, 90%; specificity, 80%; area under the curve, 0.89). No 32749060 GAS5 LncRNA Homo sapiens Arthritis, Rheumatoid RA synovial tissues regulation[HIPK2] qRT-PCR The expression of GAS5 was significantly reduced in RA synovial tissues and RA FSs, whereas the expression of homeodomain-interacting protein kinase 2 (HIPK2) was increased, indicating that it plays a critical role in inflammation and autoimmune diseases.These results indicated that GAS5 regulates RA via potentially targeting HIPK2. No 32141429 GAS5 LncRNA Homo sapiens Mouth Neoplasms 1125 oral cancer patients and 1195 non-oral-cancer individuals. Mutation(rs145204276, rs55829688 ) qRT-PCR//Bioinformatics Analysis After statistical analyses, the distribution of both the GAS5 SNP rs145204276 and GAS5 SNP rs55829688 frequencies were similar between the study and control groups. However, the patients with GAS5 SNP rs145204276 variants (Ins/Del or Del/Del) showed a higher tendency of moderate to poor cell differentiation of oral cancer (OR: 1.454, 95% CI: 1.041-2.031, p = 0.028). Moreover, the GAS5 SNP rs145204276 variants (Ins/Del or Del/Del) in the non-alcohol-drinking population were associated with significantly advanced tumor stage (OR: 1.500, 95% CI: 1.081-2.081, p = 0.015) and larger tumor size (OR: 1.494, 95% CI: 1.076-2.074, p = 0.016). Furthermore, individuals with the GAS5 SNP rs145204276 variant were associated with a higher expression of GAS5 in the GTEx database (p = 0.002), and the higher GAS5 level was associated with poor cell differentiation, advanced tumor stage and larger tumor size in head and neck squamous cell carcinoma from the TCGA database (all p < 0.05). Moreover, the GAS5 SNP rs145204276 variants (Ins/Del or Del/Del) in the non-alcohol-drinking population were associated with significantly advanced tumor stage (OR: 1.500, 95% CI: 1.081-2.081, p = 0.015) and larger tumor size (OR: 1.494, 95% CI: 1.076-2.074, p = 0.016). Furthermore, individuals with the GAS5 SNP rs145204276 variant were associated with a higher expression of GAS5 in the GTEx database (p = 0.002), and the higher GAS5 level was associated with poor cell differentiation, advanced tumor stage and larger tumor size in head and neck squamous cell carcinoma from the TCGA database (all p < 0.05). No 33925911 GAS5 LncRNA Homo sapiens Ischemic Stroke Southern Chinese Population Mutation(rs55829688, rs145204276 ) qRT-PCR//Genotyping Moreover, there was a significant association between the rs145204276 del allele and elevated expression of GAS5 in IS patients. In contrast, the frequency of the allele related to rs55829688 was not statistically correlated with IS in all analysis. No 33937403 GAS5 LncRNA Homo sapiens gastric adenocarcinoma GA tissues Expression[differently expression] qRT-PCR//Microarray The expression of 5 differentially expressed lncRNAs, HNF1A-AS1, RP11-62F24.2, GAS5, MALAT1, and H19 were randomly selected to be measured in 47 patients using real-time quantitative reverse transcription PCR (qRT-PCR), and the data were consistent with those obtained from the microarray chip. No 31850717 GAS5 LncRNA Homo sapiens Liver Cirrhosis plasma Expression[highly expressed] qRT-PCR Plasma GAS5 expression was significantly higher in patients with advanced fibrosis than in those without. No 32413995 GAS5 LncRNA Homo sapiens Diabetic Retinopathy 449 non-DR patients and 273 DR subjects Mutation(rs55829688 and rs145204276) qRT-PCR Two loci of the GAS5 SNPs (rs55829688 and rs145204276) were genotyped via TaqMan allelic discrimination in 449 non-DR patients and 273 DR subjects. The SNP rs145204276 Del/Del showed a significantly higher distribution in the DR group compared to the non-DR group (AOR: 2.487, 95% CI: 1.424-4.344, p = 0.001). During subgroup analyses, the non-proliferative diabetic retinopathy (NPDR) subgroup demonstrated a significantly higher ratio of the SNP rs145204276 Del/Del (AOR: 2.917, 95% CI: 1.574-5.406, p = 0.001) and Ins/Del + Del/Del (AOR: 1.242, 95% CI: 1.016-1.519, p = 0.034) compared to the non-DR population, while the proliferative diabetic retinopathy (PDR) subgroup did not reveal significant differences in either SNP rs145204276 or rs55829688 distributions compared to the non-DR group. Furthermore, patients with a GAS5 SNP rs145204276 Del/Del showed a significantly shorter DM duration than the wild type (Ins/Ins) (p = 0.021). No 35456391 GAS5 LncRNA Homo sapiens Coronary Disease CHD patients Interaction(miR-21) ELISA Lnc-GAS5 was increased in CHD patients compared with controls (2.270 (interquartile range [IQR]: 1.676-3.389) vs. 0.999 ([IQR: 0.602-1.409], p < 0.001), whereas miR-21 showed opposite tread (0.442 [IQR: 0.318-0.698] vs. 0.997 [IQR: 0.774-1.368], p < 0.001). No 34997773 GAS5 LncRNA Homo sapiens Coronary Disease 506 patients and 506 healthy subjects Interaction(rs17359906, rs75315904 ) Genotyping Our study showed that GAS5 rs17359906 (OR 2.32, p = 0.020) and rs75315904 (OR 0.41, p = 0.039) were related to the risk of CHD in females. ESR1 rs6927072 (OR 1.76, p = 0.007) and rs4870061 (OR 0.74, p = 0.036) correlated with CHD risk in age ≤ 60 years. GAS5 rs17359906 (OR 0.10, p = 0.032) and ESR1 rs3020308 (OR 2.73, p = 0.041) were associated with an increased susceptibility to CHD in smokers. We also found that METTL14 rs4834698 (OR 1.57, p = 0.044) and ESR1 rs4870061 (OR 0.62, p = 0.040) were associated with CHD susceptibility in non-drinkers. Besides, METTL14 rs17050450 (OR 0.48, p = 0.029) and ESR1 rs3853248 (OR 1.61, p = 0.018) had the susceptibility of CHD patients with diabetes. Our study indicated that GAS5/METTL14/ESR1 polymorphisms were associated with CHD risk, which might provide a new understanding of CHD in a Chinese population. No 35235104 GAS5 LncRNA Homo sapiens Diabetes Mellitus, Type 2 blood Expression[lower expressed] qRT-PCR//Luciferase Report Assay//RNA Pull-Down In this study, we found that the serum levels of GAS5 were significantly lower in patients with T2DM compared with healthy control subjects, and the low serum GAS5 levels were associated with high levels of HbAlc and fasting glucose in patients with T2DM. No 33195407 GAS5 LncRNA Homo sapiens Gastrointestinal Neoplasms 6107 cases and 7909 controls Mutation( rs145204276) Bioinformatics Analysis These findings provide evidence that the GAS5 rs145204276 polymorphism is associated with the susceptibility to gastrointestinal cancer. No 34521242 GAS5 LncRNA Homo sapiens Myasthenia Gravis peripheral blood mononuclear cells Regulation( IL-10) qRT-PCR//Transfection//Western Blot GAS5 and IL-10 mRNA levels in peripheral blood mononuclear cells (PBMCs) were significantly lower in MG patients than healthy controls. Downregulated GAS5 effectively distinguished MG patients from healthy controls. GAS5 expression was positively correlated with IL-10 expression in both MG patients and healthy controls. GAS5 overexpression significantly upregulated IL-10 expression in PBMCs derived from both MG patients and healthy controls. No 34936242 GAS5 LncRNA Homo sapiens Psoriasis 90 cases with plaque psoriasis and 90 age- and sex-matched healthy controls Expression(highly expressed) qRT-PCR There was significant increase of GAS5 expression level in cases when compared with controls (U = 719.0, P < 0.001). No 33719041 GAS5 LncRNA Homo sapiens Hepatitis B, Chronic Serum Mutation(rs2067079 ) qRT-PCR//Genotyping Serum expression levels of GAS5 and miR-137 were significantly down-regulated in cases vs controls. The serum GAS5 was significantly higher in the mutant TT genotype of GAS5 SNP as compared to the other genotypes (p = 0.007). No 34625583 GAS5 LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 GAS5 LncRNA Homo sapiens Purpura, Thrombocytopenic, Idiopathic 100 patients with newly diagnosed ITP Expression(lower expressed) qRT-PCR GAS5 was under-expressed, while RUNX1 was over-expressed among the newly diagnosed ITP children compared with the control group. The best cut-off values of GAS5 and RUNX1 expression that predict chronic ITP were ?0.17 and ?4.1, respectively, yielding sensitivity of 88.89% and 77.78%, respectively. GAS5 and RUNX1 could be useful markers in children with primary ITP to predict disease course. No 36731007 GAS5 LncRNA Homo sapiens Stroke serum of 181 CVS patients Expression(lower expressed) qRT-PCR LncGAS5 levels in patients were significantly lower (median (IQR) = 0.16 (0.02-0.55) and 0.25 (0.03-0.99) for the hypertensive and non-hypertensive groups, respectively) compared to controls, with a significantly lower level in the hypertensive group (P = 0.02). No 36439973 GAS5 LncRNA Homo sapiens Purpura, Thrombocytopenic, Idiopathic blood samples from children with ITP Expression(highly expressed) qRT-PCR There were overexpressed lncRNAs IFNG-AS1 and GAS5 in serum of childhood ITP patients [(median (IQR) = 3.08 (0.2-22.39) and 4.19 (0.9-16.91) respectively, Also, significant higher IFNG-AS1 and GAS5 (p < 0.05) were present in persistent ITP (3-12 months) [ median (IQR) = 4.58 (0.31-22.39) and 3.77 (0.87-12.36) respectively] or chronic ITP (>12 months) [ median (IQR) = 5.6 (0.25-12.59) and 5.61 (1.15-16.91) respectively] when compared to newly diagnosed <3 months patients [IFNG-AS1 median (IQR) = 1.21 (0.2-8.95), and GAS5 median (IQR) = 1.07 (0.09-3.55)] No 36310591 Gas5 LncRNA Mus musculus Cerebral Hemorrhage ICH mice Interaction(lncRNA GAS5/miR-378a-5p/Hspa5 Axis) In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//ELISA//Bioinformatics Analysis//ChIP . LncRNA GAS5 facilitated Hspa5 transcription by sponging miR-378a-5p. Intervention of lncRNA GAS5/miR-378a-5p/Hspa5 axis reversed the promoting effect of FoxO1 silencing on the neurological function recovery in ICH mice. No 35487009 Gas5 LncRNA Mus musculus Epilepsy brain tissue Interaction[sponging miR-135a-5p] qRT-PCR//IF//Luciferase Report Assay//Western Blot In the rat and cell models, lncRNA GAS5 was highly expressed when epileptic seizure was induced.The key findings of the present study provide evidence emphasizing that lncRNA GAS5 functions as a competitive endogenous RNA of miR-135a-5p to increase expression of KCNQ3, and lncRNA GAS5 silencing inhibited the occurrence and progression of epilepsy. No 31373759 Gas5 LncRNA Mus musculus Purpura, Thrombocytopenic, Idiopathic spleen tissues regulation[STAT3] RNA Pull-Down//Co-IP//Flow Cytometry//qRT-PCR//RIP GAS5 expression was downregulated both in PBMCs of ITP patients and spleen tissues of ITP mice. LncRNA GAS5 inhibited Th17 differentiation through promoting the TRAF6-mediated ubiquitination of STAT3, thus relieving ITP. No 31978798 GARNL3 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 GAPDHP43 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 736 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 chr4_3157199_3154293_-2906 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 467 were up-regulated and down-regulated, respectively. No 31843366 chr4_185649656_185646668_-2988 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 482 were up-regulated and down-regulated, respectively. No 31843366 hsa_circ_0007385 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Expression[highly expressed] qRT-PCR circ_0007385 expression was higher in NSCLC tissues and cell lines, and was associated with poor overall survival. circ_0007385 expression was higher in NSCLC tissues and cell lines, and was associated with poor overall survival. No 32602212 ADAMTS9-AS2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues Expression[lower expressed] qRT-PCR//Microarray The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated). No 32020063 AFAP1-AS1 LncRNA Homo sapiens Breast Neoplasms tumor tissues Expression [highly expressed] qRT-PCR AFAP1-AS1 has been demonstrated to be significantly up-regulated in tumor tissues compared with ANCTs (fold change = 4.65, P= 0.028). No significant correlation has been detected between the levels of these two transcripts in tumor tissues (R=2 0.081) or ANCTs (R=2 0.115). No significant associations have been found between expression levels of these genes and patients' characteristics. However, both genes were significantly down-regulated in Ki-67 negative tumor samples. No 29439313 AFAP1-AS1 LncRNA Homo sapiens Lymphoma, Large B-Cell, Diffuse cell lines Expression[highly expressed] Western Blot//CCK8//qRT-PCR//Cell Apoptosis Assay//Cell Cycle Assay In our previous work, we demonstrated that AFAP1-AS1 was upregulated in the GCB-DLBCL cell lines (OCI-ly1 and OCI-ly19) and tissues compared to the controls using microarray and qRT-PCR [8]. We discovered, via bioinformatics, that patients with a high expression of AFAP1-AS1 had significantly poor disease-free survival (DFS) and overall survival (OS). No 33437395 AF127936.5 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[highly expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 AF127577.4-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ADGRG3 LncRNA Homo sapiens Silicosis blood lymphocytes of eight participants Mutation(rs1814521) RNA-seq//Genotyping The presence of the SNP rs1814521 in the lncRNA ADGRG3 is associated with susceptibility to silicosis. Furthermore, five SNPs were found to be significantly correlated with the risk of silicosis by GWAS screening (P < 0.05), while the results of GWAS and iMLDR validation indicated that the variant A allele of rs1814521 was associated with a reduced risk of silicosis (OR = 0.76, 95% CI = 0.62-0.94, P = 0.011). No 35289324 ADGRD1-214 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[lower expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 ADD3-207 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 ADAR CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ADAMTSL4-AS1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 684 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ADAMTS9-AS2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung tissue and plasma Interaction( CYFRA 21-1) qRT-PCR In comparison with benign lung lesion and controls, tissue and plasma ADAMTS9-AS2 expression were significantly down-regulated in NSCLC (p < 0.001). Tissue and plasma ADAMTS9-AS2 expression levels were the predicting factors for NSCLC and they both correlated negatively with CYFRA 21-1 levels. Decreased ADAMTS9-AS2 expression was associated with TNM stages in NSCLC patients (p < 0.001). Up-regulation of CYFRA 21-1 was reported among NSCLC patients and it was associated with TNM staging. No 34312940 ADAMTS9-AS2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ADAMTS9-AS2 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Interaction[AS2/miR-32/PHLPP2] qRT-PCR Overexpression of ADAMTS9-AS2 in colon cancer cell lines significantly inhibited the miR-32 expression and promoted PHLPP2 expression, while ADAMTS9-AS2 knockdown had the opposite effects. No 31144439 ADAMTS9-AS2 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD patients Expression(lower expressed) qRT-PCR In LUAD patients, low expression of ADAMTS9-AS2 was associated with N stage (P=0.011), gender (P=0.002), number of packs smoked (P=0.024) and smoker (P<0.001). Low ADAMTS9-AS2 expression predicted a poorer overall survival (OS) (HR: 0.68; 95% CI: 0.51-0.91; P=0.01). And ADAMTS9-AS2 expression (HR: 0.626; 95% CI: 0.397-0.986; P=0.043) was independently correlated with OS in LUAD patients. In LUAD patients, low expression of ADAMTS9-AS2 was associated with N stage (P=0.011), gender (P=0.002), number of packs smoked (P=0.024) and smoker (P<0.001). Low ADAMTS9-AS2 expression predicted a poorer overall survival (OS) (HR: 0.68; 95% CI: 0.51-0.91; P=0.01). And ADAMTS9-AS2 expression (HR: 0.626; 95% CI: 0.397-0.986; P=0.043) was independently correlated with OS in LUAD patients. No 34849000 ADAMTS9-AS2 LncRNA Homo sapiens Carcinoma, Renal Cell ccRCC tissues,cell lines Expression[lower expressed] qRT-PCR ADAMTS9-AS2 was clearly downregulated in ccRCC clinical samples and cell lines. No 31400752 ADAMTS9-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 chr4_158690425_158680467_-9958 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 347 were up-regulated and down-regulated, respectively. No 31843366 ADAMTS9-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms cell lines Expression[lower expressed] qRT-PCR As shown in Figure 8A and ​andB,B, the expression of 4 lncRNAs (MIR137HG, LINC00525, ERVH48-1 and LINC00518) was upregulated, while the expression of AC110491.1 and ADAMTS9-AS1 was downregulated in MIBC tissues and bladder cancer cells (T24, J82, UM-UC-3, TCCSUP and SW780) compared with the expression in adjacent nontumor bladder tissues and the immortalized SV-HUC-1 uroepithelial cells, respectively. No 31308745 ADAMTS9-AS1 LncRNA Homo sapiens Cardiomyopathy, Hypertrophic peripheral blood samples from HCM patients Interaction(ADAMTS9-AS1/circFN1-miR-206-ACTB regulatory network) qRT-PCR//FISH//RIP//Luciferase Report Assay//Microarray ADAMTS9-AS1, circFN1, and ACTB were found to be poorly expressed, and miR-206 was highly expressed in HCM. In vitro experimentation further confirmed that ADAMTS9-AS1 and circFN1 could competitively bind to miR-206, thereby augmenting ACTB expression. No 35401927 ADAMTS7-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ADAMTS6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ADAM9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ADAM20P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 893 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ADAM15 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ADA LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ACVR2B-AS1 LncRNA Homo sapiens Endometrial Neoplasms 301 UCEC patients Regulation Bioinformatics Analysis We detected a novel lncRNA-focus expression signature (LFES) consisting of 11 lncRNAs that were associated with survival based on risk scoring strategy in UCEC. The risk score based on the LFES was able to separate patients of discovery cohort into high-risk and low-risk groups with significantly different overall survival and progression-free survival, and has been successfully confirmed in the validation cohort. No 29304762 ACTR1A-202 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 ACTG1P23 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 868 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ACTG1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ACTBP7 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 660 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ACTA2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 AFAP1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression(highly expressed) qRT-PCR The pooled analysis from five studies revealed that the AFAP1-AS1 expression was significantly associated with GC overall survival (hazard ratio (HR) = 2.49 and 95% confidence interval (95% CI): 2.02-3.08, p < 0.001). Compared with non-cancer tissues, AFAP1-AS1 expression level of GC tissues were significantly upregulated (p < 0.001), which was confirmed by the results of GEPIA. The pooled analysis from five studies revealed that the AFAP1-AS1 expression was significantly associated with GC overall survival (hazard ratio (HR) = 2.49 and 95% confidence interval (95% CI): 2.02-3.08, p < 0.001). The area under the receiver-operating characteristic (ROC) curve was 0.893, and the high expression of AFAP1-AS1 was correlated with poor prognosis in patients with GC (p = 0.005). Clinical grade (HR = 1.912, 95% CI: 1.246-2.934, p = 0.003), pathologic tumor node metastasis (pTNM) (HR = 2.393, 95% CI: 1.431-4.033, p = 0.001), log odds of positive lymph nodes (LODDS) (HR = 2.910, 95% CI: 1.787-4.793, p < 0.001) and AFAP1-AS1 expression (HR = 2.393, 95% CI: 1.869-3.064, p < 0.001) were independent prognostic factors for GC revealed by multivariate Cox-regression analysis. No 36164273 AFAP1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR Relative expressions of these two genes were associated with the location of primary tumor, in that AFAP1 and AFAP1-AS1 were significantly downregulated in all cardia tumor types compared with their paired ANCTs (P=0.04 and P=0.001, respectively). No 31086663 AFAP1‐AS1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)60) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 AFDN-DT LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 AKR1B1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 AK127309 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[lower expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 AK126393 LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Expression(lower expressed) qRT-PCR AK126393 was downregulated in bladder cancer tissues than in paracancerous ones. Its level remained lower in bladder cancer patients with stage III-IV relative to those with stage I-II. No 34565011 AK125809 LncRNA Homo sapiens brain glioma brain glioma tissues Expression[highly expressed] qRT-PCR Consistent with the microarray data, qPCR confirmed differential expression of these 6 lncRNAs (ak125809, ak098473, uc002ehu.1, bc043564, NR_027322, and uc003qmb.2) between tumor and peritumoral tissue. No 32051722 AK124454 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Expression[highly expressed] Microarray LncRNAs HIF1A-AS2 and AK124454 were upregulated in TNBCs. No 33542899 AK098783 LncRNA Homo sapiens Colorectal Neoplasms cancerous tissues Expression(highly expressed) qRT-PCR Especially, lncRNA-AK098783 expression level was frequently higher in cancerous tissues than corresponding noncancerous tissue. Higher AK098783 expression was significantly correlated with shortened overall survival (P < 0.001) and distant metastasis (P < 0.001). No 29590393 AK098473 LncRNA Homo sapiens brain glioma brain glioma tissues Expression[highly expressed] qRT-PCR Consistent with the microarray data, qPCR confirmed differential expression of these 6 lncRNAs (ak125809, ak098473, uc002ehu.1, bc043564, NR_027322, and uc003qmb.2) between tumor and peritumoral tissue. No 32051722 AK058003 LncRNA Homo sapiens Breast Neoplasms Blood Samples Expression(highly expressed) qRT-PCR The expression level of two LncRNAs in the blood samples of BC patients increased significantly compared with healthy individuals. The levels of AK058003 and MVIH were not associated with lymph node metastasis (p = 0.402 and p = 0.39), tumor size (p = 0.76 and p = 0.461), and tumor size; lymph nodes, metastasis stage (TNM; p = 0.574 and p = 0.711), respectively. The expression level of two LncRNAs in the blood samples of BC patients increased significantly compared with healthy individuals. The levels of AK058003 and MVIH were not associated with lymph node metastasis (p = 0.402 and p = 0.39), tumor size (p = 0.76 and p = 0.461), and tumor size; lymph nodes, metastasis stage (TNM; p = 0.574 and p = 0.711), respectively. No 33462225 AK056081 LncRNA Homo sapiens Arthritis, Gouty blood Expression[lower expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 AK056073 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)84) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 AK055628 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)68) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 AK055408 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] Microarray Moreover, the intersection analysis between 130 gene symbols and 73 gene symbols showed a total of nine miRNAs, and the number of targeted lncRNA was 11, which served as the differentially expressed lncRNA (Table 1). No 35117179 AK024556 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)77) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 AK001903 LncRNA Homo sapiens Arthritis, Gouty blood Expression[highly expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 AJ227913 LncRNA Homo sapiens Arthritis, Gouty blood Expression[highly expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 AJ009632.2-215 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AJ006995.3 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 AIMP1P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 626 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 AHI1-DT LncRNA Homo sapiens Adrenocortical Carcinoma ACC tissues Expression[lower expressed] qRT-PCR//Microarray In these samples, 874 lncRNAs were differentially expressed in ACC compared with NAC, of which 409 were upregulated, and 465 were downregulated. The 874 differentially expressed lncRNAs corresponded to 330 annotated lncRNA genes. Among the upregulated lncRNAs, the greatest log2 fold change was 8.5 for an unannotated lncRNA gene, and RAD50 was the geratest upregulated, annotated lncRNA gene with a log2 fold change of 6.1. Among the downregulated lncRNAs, the greatest log2 fold change was 8.3 for an unannotated lncRNA gene and 6.4 for HAND2, the greatest downregulated annotated lncRNA gene; of these, 183 differently expressed lncRNAs had established functions in cancer development and cancer progression. Selected carcinogenesis-related lncRNAs are summarized in Table 2. No 31522749 AHCTF1P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 AGPAT4-IT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 AGBL4-IT1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 745 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 AGAP2-AS1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung serum exosomes Expression[highly expressed] qRT-PCR//Western Blot The two exosomal lncRNA TBILA and AGAP2-AS1 were screened out for the higher levels in NSCLC patients than that of healthy controls in a validation set. And there was a significant positive correlation between these exosomal lncRNAs levels and tumor size, lymph node metastasis and TNM stage. No 32015683 AGAP2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 AGAP2-AS1 LncRNA Homo sapiens Colorectal Neoplasms cell lines and CRC tumor Regulation qRT-PCR In this study, we evaluated its deregulation in CRC microarray datasets, colon cell lines, CRC tumor, adenomatous colorectal polyps and their paired normal tissues. No 34308771 AGAP2-AS1 LncRNA Homo sapiens Colonic Neoplasms 408 CC (paired 204 cancer/non-cancer) tissues Mutation(rs12318065 ) qRT-PCR//IHC To our knowledge, the present study is the first to identify that the PUNISHER rs12318065 variant could be a novel putative driver of colon cancer and is associated with poor prognosis. No 35670784 AGAP2-AS1 LncRNA Homo sapiens Cholangiocarcinoma TCGA and GEO Regulation Western Blot//Transfection//Co-IP//Flow Cytometry//RIP//qRT-PCR//Luciferase Report Assay//IF We identified and constructed a 4-lncRNA (AC138430.1, AGAP2-AS1, AP001783.1, and AP005233.2) prognostic signature using regression analysis, and it had the capability to independently predict prognosis. The AUCs were 0.952, 0.909, and 0.882 at 1, 2, and 3 years, respectively, and the C-index was 0.808, which showed good predictive capability. No 34306329 AGAP1-IT1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 1016 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 AFG3L1P LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)35) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 ACTA2-AS1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 725 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ACTA2-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung LA tissues and tumor cells regulation[ZXF1/miR-634/GRB2 axis] qRT-PCR//Luciferase Report Assay//RIP//Western Blot In our in vitro experiments, qRT-PCR revealed that the expression level of ZXF1 in LA tissues and tumor cells were significantly higher than that in adjacent normal tissues and normal cells. Overall, this study demonstrated, for the first time, that the lncRNA ZXF1/miR-634/GRB2 axis plays crucial roles in modulating LA progression. No 32160453 Acr LncRNA Mus musculus Myocardial Reperfusion Injury Cardiomyocytes Interaction[Pink1/ FAM65B pathway] RNA Pull-Down//Immunoblotting//qRT-PCR//RIP//Microarray//ChIP Here we report that a circRNA, termed autophagy-related circular RNA (ACR), represses autophagy and myocardial infarction by targeting Pink1-mediated phosphorylation of FAM65B. ACR attenuates autophagy and cell death in cardiomyocytes. Moreover, ACR protects the heart from ischemia/reperfusion (I/R) injury and reduces myocardial infarct sizes. We identify Pink1 as an ACR target to mediate the function of ACR in cardiomyocyte autophagy. ACR activates Pink1 expression through directly binding to Dnmt3B and blocking Dnmt3B-mediated DNA methylation of Pink1 promoter. Pink1 suppresses autophagy and Pink1 transgenic mice show reduced myocardial infarction sizes. Further, we find that FAM65B is a downstream target of Pink1 and Pink1 phosphorylates FAM65B at serine 46. Phosphorylated FAM65B inhibits autophagy and cell death in the heart. No 30349076 AC093515.1-202 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC092635.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 AC092422.1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC092353.2-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC091493.1 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[highly expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 5 No 32547537 AC090587.1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 501 HNSCC tumor samples Regulation Bioinformatics Analysis The Prognostic Signature is based on 10 cuproptosis-related lncRNAs including AC090587.1, AC004943.2, TTN-AS1, AL162458.1, AC106820.5, AC012313.5, AL132800.1, WDFY3-AS2, CDKN2A-DT, and AL136419.3. The results of overall survival, risk score distribution, and survival status in the low-risk group were better than those in the high-risk group. In addition, all immune checkpoint genes involved were significantly different between the two risk groups (p < 0.05). The risk score was positively correlated with Eosinophils. M0 and M2 phenotype macrophages, mast cells activated, NK cells activated, and negatively related with B cells naive, mast cells resting, plasma cells, CD8T cells, T cells follicular helper, T cells regulatory (Tregs). No 35942287 AC090559.1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Regulation [down-regulated] Survival Analysis In this study, autophagy-related mRNAs-lncRNAs were screened from lung adenocarcinoma and a co-expression network of autophagy-related mRNAs-lncRNAs was constructed by using The Cancer Genome Atlas (TCGA). The univariate and multivariate Cox proportional hazard analyses were used to evaluate the prognostic value of the autophagy-related lncRNAs and finally obtained a survival model composed of 21 autophagy-related lncRNAs. No 33987935 AC084816.1-207 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC084816.1-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC084816.1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC084082.3 LncRNA Homo sapiens Gallbladder Neoplasms GBC tissues and cells Expression(highly expressed) RNA-seq//Genotyping AC084082.3 and LINC00662 showed increasing expression levels (p-value = 0.009), while C22orf34 expression decreased in the sequence from gallstones to GBC (p-value = 0.04). No 35158906 AC083949.1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC083837.1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC083809.1 LncRNA Homo sapiens Breast Neoplasms breast cancer samples Expression [lower expressed] Bioinformatics Analysis Expression levels of lnc-MICAL3-2, lnc-DDX31, LINC01063, LINC02381, ENST0000615051 and lnc-TRIM43B-1 were significantly decreased in breast cancer samples compared with paired control tissues (Posterior mean difference= -2.774, -2.012, -2.012, -2.015, -0.884 and -2.872; P values= 0.019, 0.0001, 0.0001, 0.0001, 0.032 and 0.0001, respectively). No 34175685 AC079949.1 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[lower expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 15 No 32547537 AC079848.2-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC079630.4 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 AC079298.3-202 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC079160.1-202 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC073046.25 LncRNA Homo sapiens Endometrial Neoplasms 301 UCEC patients Regulation Bioinformatics Analysis We detected a novel lncRNA-focus expression signature (LFES) consisting of 11 lncRNAs that were associated with survival based on risk scoring strategy in UCEC. The risk score based on the LFES was able to separate patients of discovery cohort into high-risk and low-risk groups with significantly different overall survival and progression-free survival, and has been successfully confirmed in the validation cohort. No 29304762 AC069277.1 LncRNA Homo sapiens Breast Neoplasms TCGA Expression [highly expressed] Bioinformatics Analysis The high expression of four core lncRNAs (AC010595.1, AC046168.1, AC069277.1, and AP000904.1) was associated with worse overall survival, while the low expression of LINC00528 and MIR762HG was associated with worse overall survival. The 6-lncRNA model has an especially good predictive power for overall survival (p < 0.0001) and 3-year survival (the area under the curve = 0.980) in HER2-positive breast cancer patients. The high expression of four core lncRNAs (AC010595.1, AC046168.1, AC069277.1, and AP000904.1) was associated with worse overall survival, while the low expression of LINC00528 and MIR762HG was associated with worse overall survival. The 6-lncRNA model has an especially good predictive power for overall survival (p < 0.0001) and 3-year survival (the area under the curve = 0.980) in HER2-positive breast cancer patients. No 34257572 AC068790.8-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC064834.3 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[highly expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 AC046168.1 LncRNA Homo sapiens Her2-receptor positive breast cancer TCGA Expression [highly expressed] Bioinformatics Analysis The high expression of four core lncRNAs (AC010595.1, AC046168.1, AC069277.1, and AP000904.1) was associated with worse overall survival, while the low expression of LINC00528 and MIR762HG was associated with worse overall survival. The 6-lncRNA model has an especially good predictive power for overall survival (p < 0.0001) and 3-year survival (the area under the curve = 0.980) in HER2-positive breast cancer patients. The high expression of four core lncRNAs (AC010595.1, AC046168.1, AC069277.1, and AP000904.1) was associated with worse overall survival, while the low expression of LINC00528 and MIR762HG was associated with worse overall survival. The 6-lncRNA model has an especially good predictive power for overall survival (p < 0.0001) and 3-year survival (the area under the curve = 0.980) in HER2-positive breast cancer patients. No 34257572 AC046134.2-208 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC044810.2-202 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC025470.2 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[lower expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 AC022075.1 LncRNA Homo sapiens Neuroblastoma Three independent gene expression datasets Regulation qRT-PCR//Western Blot Four autophagy-related lncRNAs (AL356599.1, AC022075.1, AC020928.1 and LINC02076) were found to be with the best prognostic value and integrated into a four-lncRNA risk signature for predicting PFS of NB patients. The four-lncRNA signature significantly stratify NB patients into two risk groups, with high-risk group has significantly poorer PFS than the low-risk group. No 36530992 AC022034.3-222 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC021849.1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)43) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 AC093425.1-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC095057.3 LncRNA Homo sapiens pancreatic adenocarcinoma 83 patients with PAAD Regulation CCK8//qRT-PCR//Wound Healing Assay//Western Blot Results of the present study found that a total of 409 GILncRNAs were identified, 5 of which constituted the prognostic risk signature in this study, namely, AC095057.3, AC108134.2, AC124798.1, AL606834.1, and AC104695.4. It was found that the signature of the present study was better than others in predicting the overall survival and applied to patients with PAAD of all ages, genders, and tumor grades. Results of the present study found that a total of 409 GILncRNAs were identified, 5 of which constituted the prognostic risk signature in this study, namely, AC095057.3, AC108134.2, AC124798.1, AL606834.1, and AC104695.4. It was found that the signature of the present study was better than others in predicting the overall survival and applied to patients with PAAD of all ages, genders, and tumor grades. No 35433487 ACP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 AC097376.2-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ACOT2 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ACAA1 LncRNA Homo sapiens Carcinoma, Ovarian Epithelial EOC patients Expression(highly expressed) qRT-PCR RT-qPCR showed that the relative expression level of lnc-MyD88 and MyD88 mRNA in EOC were 0.009 (0.000-0.049) and 0.001 (0.000-0.006), respectively, which were significantly higher than those of normal ovarian tissues (all P<0.01) The high expression rate of lnc-MyD88 in EOC patients with lymph node metastasis, distant metastasis and chemotherapy resistance (71%, 64% and 70%, respectively) were significantly higher than the patients in control group (41%, 40% and 35%, respectively; all P<0.05). No 35184472 AC246787.4 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[highly expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 9 No 32547537 AC242426.2-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC233296.1-211 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC148477.2 LncRNA Homo sapiens Atherosclerosis ASO arteries and all stages of proliferative VSMCs Expression(lower expressed) qRT-PCR Further verification revealed that AC147488.2 was significantly down-regulated in both ASO arteries and all stages of proliferative VSMCs, which implied that AC147488.2 might have a significant impact on ASO. No 35872920 AC147651.1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[lower expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 AC144831.1 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[lower expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 AC138430.1 LncRNA Homo sapiens Cholangiocarcinoma TCGA and GEO Regulation qRT-PCR We identified and constructed a 4-lncRNA (AC138430.1, AGAP2-AS1, AP001783.1, and AP005233.2) prognostic signature using regression analysis, and it had the capability to independently predict prognosis. The AUCs were 0.952, 0.909, and 0.882 at 1, 2, and 3 years, respectively, and the C-index was 0.808, which showed good predictive capability. No 34034689 AC138409.2-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC138128.1 LncRNA Homo sapiens Lung Neoplasms Lung Cancer tissues Interaction[ERCC1] qRT-PCR Firstly, the qRT-PCR data showed that AC138128.1 expression was much lower in lung cancer comparing with its para-cancer tissues, which further analyzed by ROC curve.Therefore, as a preliminary exploration of the lncRNA originated from ERCC1, the present study suggested AC138128.1 is of potential value in predicting platinum analogue benefit in lung cancer. No 31333777 AC136475.9 LncRNA Homo sapiens COVID-19 39 COVID-19 patients Regulation qRT-PCR//Microarray All patients with COVID-19 displayed lymphopenia, especially in T cells, and hyper-inflammatory responses, including IL-6 and TNF-α. Four immune-related lncRNAs in COVID-19 were found and further validated, including AC136475.9, CATG00000032642.1, G004246, and XLOC_013290. No 35573725 AC133644.2 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[highly expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 AC124798.1 LncRNA Homo sapiens pancreatic adenocarcinoma 83 patients with PAAD Regulation CCK8//qRT-PCR//Wound Healing Assay//Western Blot Results of the present study found that a total of 409 GILncRNAs were identified, 5 of which constituted the prognostic risk signature in this study, namely, AC095057.3, AC108134.2, AC124798.1, AL606834.1, and AC104695.4. It was found that the signature of the present study was better than others in predicting the overall survival and applied to patients with PAAD of all ages, genders, and tumor grades. Results of the present study found that a total of 409 GILncRNAs were identified, 5 of which constituted the prognostic risk signature in this study, namely, AC095057.3, AC108134.2, AC124798.1, AL606834.1, and AC104695.4. It was found that the signature of the present study was better than others in predicting the overall survival and applied to patients with PAAD of all ages, genders, and tumor grades. No 35433487 AC124068.2 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[lower expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 AC124067.2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patients Regulation Bioinformatics Analysis We identified and independently verified the ATG (AL691432.2, MMP2-AS1, AC124067.2, CRNDE, ABALON, AL161431.1, NKILA) in NSCLC patients and found that immune regulation in the tumor microenvironment is closely related to this gene. No 34849558 AC117383.1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC110491.1 LncRNA Homo sapiens Urinary Bladder Neoplasms cell lines Expression[lower expressed] qRT-PCR As shown in Figure 8A and ​andB,B, the expression of 4 lncRNAs (MIR137HG, LINC00525, ERVH48-1 and LINC00518) was upregulated, while the expression of AC110491.1 and ADAMTS9-AS1 was downregulated in MIBC tissues and bladder cancer cells (T24, J82, UM-UC-3, TCCSUP and SW780) compared with the expression in adjacent nontumor bladder tissues and the immortalized SV-HUC-1 uroepithelial cells, respectively. No 31308745 AC108134.2 LncRNA Homo sapiens pancreatic adenocarcinoma 83 patients with PAAD Regulation CCK8//qRT-PCR//Wound Healing Assay//Western Blot Results of the present study found that a total of 409 GILncRNAs were identified, 5 of which constituted the prognostic risk signature in this study, namely, AC095057.3, AC108134.2, AC124798.1, AL606834.1, and AC104695.4. It was found that the signature of the present study was better than others in predicting the overall survival and applied to patients with PAAD of all ages, genders, and tumor grades. Results of the present study found that a total of 409 GILncRNAs were identified, 5 of which constituted the prognostic risk signature in this study, namely, AC095057.3, AC108134.2, AC124798.1, AL606834.1, and AC104695.4. It was found that the signature of the present study was better than others in predicting the overall survival and applied to patients with PAAD of all ages, genders, and tumor grades. No 35433487 AC107072.2 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[lower expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 17 No 32547537 AC106820.5 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 501 HNSCC tumor samples Regulation Bioinformatics Analysis The Prognostic Signature is based on 10 cuproptosis-related lncRNAs including AC090587.1, AC004943.2, TTN-AS1, AL162458.1, AC106820.5, AC012313.5, AL132800.1, WDFY3-AS2, CDKN2A-DT, and AL136419.3. The results of overall survival, risk score distribution, and survival status in the low-risk group were better than those in the high-risk group. In addition, all immune checkpoint genes involved were significantly different between the two risk groups (p < 0.05). The risk score was positively correlated with Eosinophils. M0 and M2 phenotype macrophages, mast cells activated, NK cells activated, and negatively related with B cells naive, mast cells resting, plasma cells, CD8T cells, T cells follicular helper, T cells regulatory (Tregs). No 35942287 AC106047.1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Expression [lower expressed] Survival Analysis In this study, autophagy-related mRNAs-lncRNAs were screened from lung adenocarcinoma and a co-expression network of autophagy-related mRNAs-lncRNAs was constructed by using The Cancer Genome Atlas (TCGA). The univariate and multivariate Cox proportional hazard analyses were used to evaluate the prognostic value of the autophagy-related lncRNAs and finally obtained a survival model composed of 12 autophagy-related lncRNAs. No 33987935 AC105942.1-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC104695.4 LncRNA Homo sapiens pancreatic adenocarcinoma 83 patients with PAAD Regulation CCK8//qRT-PCR//Wound Healing Assay//Western Blot Results of the present study found that a total of 409 GILncRNAs were identified, 5 of which constituted the prognostic risk signature in this study, namely, AC095057.3, AC108134.2, AC124798.1, AL606834.1, and AC104695.4. It was found that the signature of the present study was better than others in predicting the overall survival and applied to patients with PAAD of all ages, genders, and tumor grades. Results of the present study found that a total of 409 GILncRNAs were identified, 5 of which constituted the prognostic risk signature in this study, namely, AC095057.3, AC108134.2, AC124798.1, AL606834.1, and AC104695.4. It was found that the signature of the present study was better than others in predicting the overall survival and applied to patients with PAAD of all ages, genders, and tumor grades. No 35433487 AC104532.2 LncRNA Homo sapiens Colorectal Neoplasms colorectal cancer tissues Expression(highly expressed) qRT-PCR//Bioinformatics Analysis We found that lncRNAs AC156455.1 and AC104532.2 were upregulated in twelve colorectal cancer tissues compared with adjacent normal tissues using qRT-PCR. No 36277972 AC104389.4-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC099524.1 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[highly expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 AC099522.2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)9) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 AC097523.1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)18) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 AKR1B1P3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 824 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 AKR1C6P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 AKR7A2P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ARFGAP1-205 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[lower expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 ARAP1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC samples Expression[highly expressed] qRT-PCR The levels of ARAP1-AS1 were dramatically increased in GC samples compared with paired adjacent non-tumor specimens (p=0.01). The upregulation of ARAP1-AS1 was distinctly associated with TNM stage (p=0.010) and lymphatic metastasis (p=0.007). Further survival study revealed that patients with higher levels of ARAP1-AS1 had shorter overall survival (p=0.0020) and disease-free survival than those with lower levels of ARAP1-AS1. No 32141550 ARAP1-AS1 LncRNA Homo sapiens Urinary Bladder Neoplasms BCa tissues,cell lines Regulation[miR-4735-3p/NOTCH2 axis] Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay LncRNA ARAP1-AS1 was chosen to be the object of this study due to it was significantly upregulated in the BCa samples of TCGA database. qRT-PCR further validated the dysregulation of ARAP1-AS1 in 88 pairs of BCa tissues and six BCa cells.Mechanically, ARAP1-AS1 was enriched in the cytoplasm of BCa cells, suggesting that ARAP1-AS1 might act as a ceRNA to regulate gene expression and biological processes in bladder cancer. It was certified that ARAP1-AS1 can bind with miR-4735-3p in BCa cells. No 30404578 ARAP1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)113) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 AQP7P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 AQP4-AS1 LncRNA Homo sapiens Breast Neoplasms 306 BC patients and 312 controls Mutation(rs527616 ) Genotyping According to TCGA data, AQP4-AS1 is down-regulated in BC tissue, and the overexpression is associated with better prognoses, including Luminal A, HER2-, stage 1 of disease and smaller tumor. According to TCGA data, AQP4-AS1 is down-regulated in BC tissue, and the overexpression is associated with better prognoses, including Luminal A, HER2-, stage 1 of disease and smaller tumor. No 33721012 APTR LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Expression[lower expressed] qRT-PCR qPCR results indicated marked upregulation of CDKN2A-AS1, C7orf55, LINC00184, HEIH, and ZEB2 expression, whereas that of SNHG3, LINC00630, LOC100133669, APTR, LINC-PINT, and SEMA5A was downregulated in OC tissues as compared with levels in normal ovary tissues (Fig. ?(Fig.5b5b). No 31098301 APOL2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)86) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 APOC4-APOC2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 APOC1P1-3 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer specimens Expression(highly expressed) qRT-PCR The APOC1P1-3 expression was significantly increased in cervical cancer specimens as compared to adjacent non-tumorous specimens (p < 0.0001). The overexpression of APOC1P1-3 was significantly observed in patients younger than 50 years old as compared to another age group (p = 0.033). A significant association was also observed between APOC1P1-3 expression and lymph node involvement (p = 0.031). Additionally, APOC1P1-3 expression demonstrated a significant association with the depth of tumor invasion (p = 0.035), and squamous type of cervical cancer (p = 0.019). No 36564178 APOA1-AS LncRNA Homo sapiens Multiple Sclerosis blood Expression[highly expressed] qRT-PCR APOA1-AS, IFNG-AS1, SPHK1 & 2, and S1PR5 were upregulated in RRMS patients. No 32071782 APOA1-AS LncRNA Homo sapiens Coronary Artery Disease blood Expression[highly expressed] qRT-PCR We found that the levels of lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1), hypoxia-inducible factor 1 alpha-antisense RNA 2 (HIF1A-AS2) and apolipoprotein A-1 antisense RNA (APOA1-AS) were significantly increased in CAD patients (KCNQ1OT1 increased by 2.38-fold, P = 0.00042; HIF1A-AS2 increased by 2.00-fold, P = 0.0001; APOA1-AS increased by 4.52-fold, P = 0.000048). No 30941792 APLP2-220 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 APF LncRNA Homo sapiens acute myocardial infarction patients with AMI Expression(highly expressed) qRT-PCR//ELISA The levels of lncRNA APF, MIAT, MALAT1, H19, CHAST, and CDR1AS in patients with AMI were increased, whereas there were no differences in patients with AP. The APF levels in patients with AMI were higher than MIAT, MALAT1, and CHAST, whereas there were no differences between APF and H19 and CDR1AS. In patients with AMI, the high level of lncRNA APF was correlated with the history of smoking/drinking. Moreover, lncRNA APF was positively correlated with cTnI/CK/CK-MB levels and negatively correlated with miR-188-3p. LncRNA APF has high diagnostic efficacy for AMI. Overall, lncRNA APF is highly expressed in patients with AMI caused by CHD and has high diagnostic efficacy for AMI. No 35831141 APCDD1L-DT LncRNA Homo sapiens lung squamous cell carcinoma TCGA(409 LSCC and 49 control samples) Regulation Bioinformatics Analysis Kaplan-Meier survival curves revealed prognostic capabilities for three of these lncRNAs (LINC02555, APCDD1L-DT and OTX2-AS1). A Cox regression analysis revealed this three-lncRNA signature to be significantly associated with patient survival. A Cox regression analysis revealed this three-lncRNA signature to be significantly associated with patient survival. No 33910626 AP2M1-216 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 AP2M1-214 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 AP1G2-209 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AP005233.2 LncRNA Homo sapiens Cholangiocarcinoma TCGA and GEO Regulation In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Flow Cytometry//qRT-PCR//CCK8//RIP//Transwell Assay//IF We identified and constructed a 4-lncRNA (AC138430.1, AGAP2-AS1, AP001783.1, and AP005233.2) prognostic signature using regression analysis, and it had the capability to independently predict prognosis. The AUCs were 0.952, 0.909, and 0.882 at 1, 2, and 3 years, respectively, and the C-index was 0.808, which showed good predictive capability. No 34401209 AP004608.1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Expression(lower expressed) Meta-analysis Low AP004608.1 expression predicted favorable Overall survival (OS) and Progression-free survival (PFS) in PCa patients, according to the Cancer Genome Atlas (TCGA) database. Low AP004608.1 expression predicted favorable Overall survival (OS) and Progression-free survival (PFS) in PCa patients, according to the Cancer Genome Atlas (TCGA) database. No 36249054 AP003555.2 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Regulation Bioinformatics Analysis Combined with the overall survival data, we established 6 six lncRNA-based signature to predict prognosis, which were LINC00896, AC007996.1, NKILA, AP003555.2, MIRLET7BHG, and AC009237.14. We found that the expression level of PD-L1 (CD274) and somatic mutations in the high-risk group were higher than those in the low-risk group. No 34790382 AP002026.1-210 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AP001783.1 LncRNA Homo sapiens Cholangiocarcinoma TCGA and GEO Regulation In Vivo Experiment//Transfection//CCK8//qRT-PCR//Flow Cytometry//FISH//Luciferase Report Assay//EdU Staining We identified and constructed a 4-lncRNA (AC138430.1, AGAP2-AS1, AP001783.1, and AP005233.2) prognostic signature using regression analysis, and it had the capability to independently predict prognosis. The AUCs were 0.952, 0.909, and 0.882 at 1, 2, and 3 years, respectively, and the C-index was 0.808, which showed good predictive capability. No 34459789 AP001347.6 LncRNA Homo sapiens Endometrial Neoplasms 301 UCEC patients Regulation Bioinformatics Analysis We detected a novel lncRNA-focus expression signature (LFES) consisting of 11 lncRNAs that were associated with survival based on risk scoring strategy in UCEC. The risk score based on the LFES was able to separate patients of discovery cohort into high-risk and low-risk groups with significantly different overall survival and progression-free survival, and has been successfully confirmed in the validation cohort. No 29304762 AP001171.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 AP000904.1 LncRNA Homo sapiens Breast Neoplasms TCGA Expression [highly expressed] Bioinformatics Analysis The high expression of four core lncRNAs (AC010595.1, AC046168.1, AC069277.1, and AP000904.1) was associated with worse overall survival, while the low expression of LINC00528 and MIR762HG was associated with worse overall survival. The 6-lncRNA model has an especially good predictive power for overall survival (p < 0.0001) and 3-year survival (the area under the curve = 0.980) in HER2-positive breast cancer patients. The high expression of four core lncRNAs (AC010595.1, AC046168.1, AC069277.1, and AP000904.1) was associated with worse overall survival, while the low expression of LINC00528 and MIR762HG was associated with worse overall survival. The 6-lncRNA model has an especially good predictive power for overall survival (p < 0.0001) and 3-year survival (the area under the curve = 0.980) in HER2-positive breast cancer patients. No 34257572 AP000787.1-209 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AP000350.8 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)81) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 AP000253 LncRNA Homo sapiens Hepatitis B virus liver tissues and serum Expression(lower expressed) qRT-PCR//Transfection Among candidate lncRNAs, the plasma level of AP000253 decreased significantly in OBI, ASC and CHB patients compared to HCs, while no difference was found among OBI, ASC and CHB patients. In liver tissues, similar AP000253 expression was also observed from the GSE83148 dataset, while that in HBV-expressing hepatoma cells was opposite. ROC curve analysis indicated that plasma AP000253 yielded an AUC of 0.73 with 60% sensitivity and 75% specificity when differentiating OBI from HCs, but it could not specifically separate the stage of chronic HBV infection. Furthermore, functional experiments suggested that AP000253 could promote HBV transcription and replication in hepatoma cell lines. ROC curve analysis indicated that plasma AP000253 yielded an AUC of 0.73 with 60% sensitivity and 75% specificity when differentiating OBI from HCs, but it could not specifically separate the stage of chronic HBV infection. No 34112188 AOX2P LncRNA Homo sapiens Leukemia, Myeloid, Acute blood Expression(highly expressed) Bioinformatics Analysis Upregulated CRNDE expression was independently associated with lower complete remission (CR) rates in the whole cohort of AML (P < .001). AOX2P overexpression was identified as an independent adverse prognostic marker for CR in the CN-AML (P = .009) and non-t (15;17) AML (P < .001) subgroups. Patients with high CRNDE expression had a significantly shorter event-free survival (EFS, whole cohort of AML: P = .017; CN-AML: P = .001; non-t (15;17) AML: P = .006) and inferior overall survival (OS, whole cohort of AML: P = .002; t(15;17) AML: P = .001) than those with low CRNDE expression. EFS and OS did not differ significantly between patients with high AOX2P expression and those with low expression. Upregulated CRNDE expression was independently associated with lower complete remission (CR) rates in the whole cohort of AML (P < .001). AOX2P overexpression was identified as an independent adverse prognostic marker for CR in the CN-AML (P = .009) and non-t (15;17) AML (P < .001) subgroups. Patients with high CRNDE expression had a significantly shorter event-free survival (EFS, whole cohort of AML: P = .017; CN-AML: P = .001; non-t (15;17) AML: P = .006) and inferior overall survival (OS, whole cohort of AML: P = .002; t(15;17) AML: P = .001) than those with low CRNDE expression. EFS and OS did not differ significantly between patients with high AOX2P expression and those with low expression. No 34129278 ARCN1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ARFGEF3 CircRNA Homo sapiens Stomach Neoplasms GC tissues, plasmas, and cells Expression[lower expressed] qRT-PCR Results showed lower expression of circ-KIAA1244 in GC tissues, plasmas, and cells compare to normal controls. Further clinical data analysis demonstrated that a decreased expression of circ-KIAA1244 in plasmas was negatively correlated with TNM stage and lymphatic metastasis, and a shorter overall survival time of GC patients. No 30236115 ANXA2R-AS1 LncRNA Homo sapiens Sjogren's Syndrome blood Expression[lower expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 ARHGAP26 CircRNA Homo sapiens Stomach Neoplasms cell line Expression[highly expressed] CCK8//qRT-PCR//Western Blot The circ-ARHGAP26 expression was elevated in HGC-27 (P < 0.001), AGS (P < 0.001), SGC-7901 (P < 0.01), BGC-823 (P < 0.05) and NCI-N87 (P < 0.05) GC cell lines compared to GSE-1 cells. In HGC-27 cells, CCK8 assay revealed that cell proliferation was decreased at 48 h (P < 0.05) and 72 h (P < 0.01), while AV/PI assay disclosed that cell apoptosis rate was increased at 72 h in circ-ARHGAP26 (-) group compared to NC (-) group (P < 0.01). Western blot assay also illuminated that apoptotic marker C-Caspase 3 was raised, while anti-apoptotic marker Bcl-2 was reduced at 72 h in circ-ARHGAP26 (-) group compared to NC (-) group. In addition, further validation in AGS cells also exhibited that cells proliferation was repressed, while apoptosis was enhanced in circ-ARHGAP26 (-) group compared to NC (-) group. No 30719998 ATG9B LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissues Interaction[represses miR-34a, miR-15a, miR-16, and let-7a] Western Blot//Wound Healing Assay//qRT-PCR//MTT//Colony Formation Assay Results showed that sONE is restrictedly expressed in TNBC patients; its expression level is inversely correlated with the aggressiveness of the disease. sONE acts as a posttranscriptional regulator to endothelial nitric oxide synthase (eNOS) and thus affecting eNOS-induced nitric oxide (NO) production from TNBC cells measured by Greiss reagent. Mechanistically, sONE is a potential tumor suppressor lncRNA in TNBC cells; repressing cellular viability, proliferation, colony-forming ability, migration, and invasion capacities of MDA-MB-231. Furthermore, sONE effects were found to be extended to affect the maestro tumor suppressor TP53 and the oncogenic transcription factor c-Myc. Knocking down of sONE resulted in a marked decrease in TP53 and increase in c-Myc and consequently altering the expression status of their downstream tumor suppressor microRNAs (miRNAs) such as miR-34a, miR-15, miR-16, and let-7a. No 30968427 ATG5 CircRNA Homo sapiens Stomach Neoplasms blood Expression[lower expressed] qRT-PCR//circRNA-seq The top 5 up- and downregulated circRNAs in patients with are listed in Table IV. No 32765789 ATG5 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ATB LncRNA Homo sapiens Breast Neoplasms Serum Expression[highly expressed] qRT-PCR We found that FAM83H-AS1 and lncRNA-ATB were significantly overexpressed in sera of breast cancer patients compared to controls (p = 0.000 for both). No 32763293 ATB LncRNA Homo sapiens Breast Neoplasms 73 patients diagnosed with breast cancer Expression(highly expressed) PCR The experimental results show that lncRNA ATB and Nek9 in 3 groups are significantly different, and group A> group B> group C (all P < 0.05). The expression of lncRNA ATB and Nek9 is closely associated with lymph node metastasis and TNM stage in breast cancer patients (P < 0.05). Besides, the Spearman correlation coefficient shows that lncRNA ATB and Nek9 are positively correlated with breast cancer incidence (P < 0.05). It is evident that lncRNA ATB and Nek9 are expressed at high levels in breast cancer patients and are positively correlated with the occurrence and development of the disease. The experimental results show that lncRNA ATB and Nek9 in 3 groups are significantly different, and group A> group B> group C (all P < 0.05). The expression of lncRNA ATB and Nek9 is closely associated with lymph node metastasis and TNM stage in breast cancer patients (P < 0.05). Besides, the Spearman correlation coefficient shows that lncRNA ATB and Nek9 are positively correlated with breast cancer incidence (P < 0.05). It is evident that lncRNA ATB and Nek9 are expressed at high levels in breast cancer patients and are positively correlated with the occurrence and development of the disease. No 35935324 ATB LncRNA Homo sapiens Colorectal Neoplasms " CRC tissues" Interaction[targeting miR-200c] qRT-PCR//Luciferase Report Assay//Western Blot "the Luciferase reporter gene assay was carried out to judge if there existed a targeted relationship between ATB and miR-200c. Among the recruited patients with CRC, their CRC tissues exhibited higher ATB expression and lower miR‐200c expression than adjacent nontumor tissues" The results of Cox regression analyses suggested that overexpressed lncRNA ATB, underexpressed miR-200c, poor tumor differentiation, lymph-vascular invasion, and perineural invasion were symbolic of shortened survival of the patients with CRC (all P < .05). No 31222825 ATB LncRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR Briefly, after plasma separation and total RNA extraction, RNAs were reversely transcribed to complementary DNA followed by amplification using a quantitative real-time polymerase chain reaction technique for lncRNA expression analysis. The results showed that the expression levels of lnc-ATB (p < 0.001) and CCAT1 (p = 0.024), but not OCC-1 (p = 0.24), were significantly upregulated in the CRC compared with the healthy group. No 31093977 ATB LncRNA Homo sapiens Uterine Cervical Neoplasms cell lines (HeLa, MS750, Caski, SiHa,C-33A,H8) Interaction[ ATB/miR-144/ITGA6 axis ] qRT-PCR//MTT//Luciferase Report Assay//Western Blot Compared with H8 cells, cervical cancer cells exhibited significantly higher levels of lncRNA ATB (Figure 1a), suggesting that lncRNA ATB might be involved in the progression of cervical cancer. In conclusion, the lncRNA ATB/miR-144/ITGA6 axis might be a promising therapeutic target for cervical cancer. No 30908730 ATB LncRNA Homo sapiens Glioma cell lines Interaction[NF-κB and P38/MAPK pathway] qRT-PCR//Transwell Assay//Western Blot Results showed that TGF-β upregulated lncRNA-ATB expression in glioma LN-18 and U251 cells. Overexpression of lncRNA-ATB activated nuclear factor-κB (NF-κB) pathway and promoted P65 translocation into the nucleus, thus facilitated glioma cells invasion stimulated by TGF-β. Similarly, lncRNA-ATB markedly enhanced TGF-β-mediated invasion of glioma cells through activation P38 mitogen-activated protein kinase (P38/MAPK) pathway. Moreover, both the NF-κB selected inhibitor pyrrolidinedithiocarbamate ammonium and P38/MAPK specific inhibitor SB203580 partly reversed lncRNA-ATB induced glioma cells invasion mediated by TGF-β. No 31140621 ATB LncRNA Homo sapiens laryngeal carcinoma laryngeal carcinoma tissue Expression[highly expressed] qRT-PCR LncRNA-ATB expression was markedly enhanced in laryngeal carcinoma tissue samples compared to the corresponding normal ones, which was relevant to T grade and clinical stage. LncRNA-ATB expression was markedly enhanced in laryngeal carcinoma tissue samples compared to the corresponding normal ones, which was relevant to T grade and clinical stage. In addition, the overall survival rate of patients with high expression of lncRNA-ATB was markedly lower than those in low expression group. Meanwhile, T grade, clinical stage and lncRNA-ATB are found as three independent factors influencing the prognosis of LNCa. No 33215432 ATB LncRNA Homo sapiens Digestive System Neoplasms Expression[highly expressed] Meta-analysis High expression of lncRNA-ATB was significantly correlated with poor prognosis for most DSCs. The expression level of lncRNA-ATB could be a promising prognostic biomarker for DSC patients. No 32791727 ASMTL-AS1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[highly expressed] qRT-PCR LncRNA ASMTL-AS1 low expressed in normal human liver was found to be highly expressed in HCC tissues and further increased in tumours after insufficient RFA. No 32722884 ASB3 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 ASB16-AS1 LncRNA Homo sapiens Colorectal Neoplasms tissue and plasma Expression(highly expressed) IF High expression levels of ASB16-AS1 in tissue and plasma and tissue lncRNA AFAP1-AS1 are significantly correlated with decreased overall survival (p < 0.001) and reduced progression-free (p < 0.001) compared to low expression in CRC patients. High expression levels of ASB16-AS1 in tissue and plasma and tissue lncRNA AFAP1-AS1 are significantly correlated with decreased overall survival (p < 0.001) and reduced progression-free (p < 0.001) compared to low expression in CRC patients. No 35937710 ASAP1-IT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ARSB-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 ARRDC3-205 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 ARPC1B-219 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 ARPC1B-218 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 ARL6IP6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ARL4AP2 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 862 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ARHGEF11 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ARHGEF10 CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 ARHGEF1 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ARHGAP6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ARHGAP5-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ARHGAP27P1-BPTFP1-KPNA2P3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ARHGAP27P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 AOC4P LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[lower expressed] qRT-PCR Our results revealed a significant downregulation of AOC4P, however, upregulated PRNCR1 and PCAT1 were found in tumor tissues compared to NATs and clinically healthy normal tissues (P < 0.05). No 32853955 ANXA1-206 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 AKT1-218 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 AL606489.1 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Expression [highly expressed] Survival Analysis In this study, autophagy-related mRNAs-lncRNAs were screened from lung adenocarcinoma and a co-expression network of autophagy-related mRNAs-lncRNAs was constructed by using The Cancer Genome Atlas (TCGA). The univariate and multivariate Cox proportional hazard analyses were used to evaluate the prognostic value of the autophagy-related lncRNAs and finally obtained a survival model composed of 16 autophagy-related lncRNAs. No 33987935 AL592284.1 LncRNA Homo sapiens Uterine Cervical Neoplasms plasma Expression[highly expressed] qRT-PCR We discovered 4 lncRNAs including HOTAIR, PVT1, XLOC_000303, and AL592284.1, which were upregulated in CC comparing with the cancer-free controls. No 30134241 AL590999.1 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[lower expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 AL589740.1 LncRNA Homo sapiens Alzheimer Disease AA patients Mutation(rs9320913 ) Genotyping We found that rs9320913 maps within a central nervous system lincRNA AL589740.1. eQTL results show that rs9320913 correlated with the brain-frontal cortex (beta = -0.15, p value = 0.057) and brain-spinal cord (beta of -0.23, p value = 0.037). We did not find rs9320913 to be associated to AD risk, although AA patients seemed to exhibit a less pronounced Mini-Mental State Exam score decline. No 34557314 AL583808.1-208 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AL390243.1 LncRNA Mus musculus estrogen-receptor positive breast cancer HER2+ breast cancer tissues Expression(highly expressed) qRT-PCR//Microarray Our results demonstrated that three lncRNA sets, lncRNA-AL390243.1, POTEH-AS1, and lncRNA-AC009975.1, were up-regulated in non-apCR tissues. No 34938660 AL390066.1 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[highly expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 AL359715.1 LncRNA Homo sapiens Leukemia TCGA(151 samples from 151 patients) Regulation Bioinformatics Analysis A four-autophagy related lncRNA (MIR133A1HG, AL359715.1, MIRLET7BHG, and AL356752.1) signature was established. The high risk score based on signature was related to the short survival time of AML patients. The signature was an independent factor for the prognosis for AML patients (HR = 1.684, 95% CI = 1.324-2.142, P < 0.001). A four-autophagy related lncRNA (MIR133A1HG, AL359715.1, MIRLET7BHG, and AL356752.1) signature was established. The high risk score based on signature was related to the short survival time of AML patients. The signature was an independent factor for the prognosis for AML patients (HR = 1.684, 95% CI = 1.324-2.142, P < 0.001). No 34276784 AL359643.3-216 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AL356752.1 LncRNA Homo sapiens Leukemia TCGA(151 samples from 151 patients) Regulation Bioinformatics Analysis A four-autophagy related lncRNA (MIR133A1HG, AL359715.1, MIRLET7BHG, and AL356752.1) signature was established. The high risk score based on signature was related to the short survival time of AML patients. The signature was an independent factor for the prognosis for AML patients (HR = 1.684, 95% CI = 1.324-2.142, P < 0.001). A four-autophagy related lncRNA (MIR133A1HG, AL359715.1, MIRLET7BHG, and AL356752.1) signature was established. The high risk score based on signature was related to the short survival time of AML patients. The signature was an independent factor for the prognosis for AML patients (HR = 1.684, 95% CI = 1.324-2.142, P < 0.001). No 34276784 AL356599.1 LncRNA Homo sapiens Neuroblastoma Three independent gene expression datasets Regulation qRT-PCR//Western Blot Four autophagy-related lncRNAs (AL356599.1, AC022075.1, AC020928.1 and LINC02076) were found to be with the best prognostic value and integrated into a four-lncRNA risk signature for predicting PFS of NB patients. The four-lncRNA signature significantly stratify NB patients into two risk groups, with high-risk group has significantly poorer PFS than the low-risk group. No 36530992 AL356489.2 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[lower expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 AL162717.1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AL162458.1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 501 HNSCC tumor samples Regulation Bioinformatics Analysis The Prognostic Signature is based on 10 cuproptosis-related lncRNAs including AC090587.1, AC004943.2, TTN-AS1, AL162458.1, AC106820.5, AC012313.5, AL132800.1, WDFY3-AS2, CDKN2A-DT, and AL136419.3. The results of overall survival, risk score distribution, and survival status in the low-risk group were better than those in the high-risk group. In addition, all immune checkpoint genes involved were significantly different between the two risk groups (p < 0.05). The risk score was positively correlated with Eosinophils. M0 and M2 phenotype macrophages, mast cells activated, NK cells activated, and negatively related with B cells naive, mast cells resting, plasma cells, CD8T cells, T cells follicular helper, T cells regulatory (Tregs). No 35942287 AL161626.1 LncRNA Homo sapiens Inflammatory Bowel Diseases IBD tissue Expression[lower expressed] qRT-PCR//Luciferase Report Assay In addition, the top 10 upregulated and the top 10 downregulated DELs in IBD patients compared to HCs were selected by rank of absolute value of Log2FC which are listed in Table 16 No 32547537 AL161431.1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patients Regulation Bioinformatics Analysis We identified and independently verified the ATG (AL691432.2, MMP2-AS1, AC124067.2, CRNDE, ABALON, AL161431.1, NKILA) in NSCLC patients and found that immune regulation in the tumor microenvironment is closely related to this gene. No 34849558 AL159156.1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AL139158.2-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AL138720.1 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[highly expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 AL136419.3 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 501 HNSCC tumor samples Regulation Bioinformatics Analysis The Prognostic Signature is based on 10 cuproptosis-related lncRNAs including AC090587.1, AC004943.2, TTN-AS1, AL162458.1, AC106820.5, AC012313.5, AL132800.1, WDFY3-AS2, CDKN2A-DT, and AL136419.3. The results of overall survival, risk score distribution, and survival status in the low-risk group were better than those in the high-risk group. In addition, all immune checkpoint genes involved were significantly different between the two risk groups (p < 0.05). The risk score was positively correlated with Eosinophils. M0 and M2 phenotype macrophages, mast cells activated, NK cells activated, and negatively related with B cells naive, mast cells resting, plasma cells, CD8T cells, T cells follicular helper, T cells regulatory (Tregs). No 35942287 AL135999.1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Epigenetics(m6A ) qRT-PCR//RIP In summary, we constructed a reliable 2-lncRNAs signature based on the risk score, and we identified two m6A-related prognostic lncRNAs, AL135999.1 and AL049840.4. No 34976168 AL132800.1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 501 HNSCC tumor samples Regulation Bioinformatics Analysis The Prognostic Signature is based on 10 cuproptosis-related lncRNAs including AC090587.1, AC004943.2, TTN-AS1, AL162458.1, AC106820.5, AC012313.5, AL132800.1, WDFY3-AS2, CDKN2A-DT, and AL136419.3. The results of overall survival, risk score distribution, and survival status in the low-risk group were better than those in the high-risk group. In addition, all immune checkpoint genes involved were significantly different between the two risk groups (p < 0.05). The risk score was positively correlated with Eosinophils. M0 and M2 phenotype macrophages, mast cells activated, NK cells activated, and negatively related with B cells naive, mast cells resting, plasma cells, CD8T cells, T cells follicular helper, T cells regulatory (Tregs). No 35942287 AL096854.1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AL050403.2-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AL049840.4 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues and cell lines Epigenetics(m6A ) qRT-PCR//RIP In summary, we constructed a reliable 2-lncRNAs signature based on the risk score, and we identified two m6A-related prognostic lncRNAs, AL135999.1 and AL049840.4. No 34976168 AL049828.1-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AL034405.1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AL034397.3 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Expression [lower expressed] Survival Analysis In this study, autophagy-related mRNAs-lncRNAs were screened from lung adenocarcinoma and a co-expression network of autophagy-related mRNAs-lncRNAs was constructed by using The Cancer Genome Atlas (TCGA). The univariate and multivariate Cox proportional hazard analyses were used to evaluate the prognostic value of the autophagy-related lncRNAs and finally obtained a survival model composed of 14 autophagy-related lncRNAs. No 33987935 AL032819.2 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[highly expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 AL031599.1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AL603840.1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AL606834.1 LncRNA Homo sapiens pancreatic adenocarcinoma 83 patients with PAAD Regulation CCK8//qRT-PCR//Wound Healing Assay//Western Blot Results of the present study found that a total of 409 GILncRNAs were identified, 5 of which constituted the prognostic risk signature in this study, namely, AC095057.3, AC108134.2, AC124798.1, AL606834.1, and AC104695.4. It was found that the signature of the present study was better than others in predicting the overall survival and applied to patients with PAAD of all ages, genders, and tumor grades. Results of the present study found that a total of 409 GILncRNAs were identified, 5 of which constituted the prognostic risk signature in this study, namely, AC095057.3, AC108134.2, AC124798.1, AL606834.1, and AC104695.4. It was found that the signature of the present study was better than others in predicting the overall survival and applied to patients with PAAD of all ages, genders, and tumor grades. No 35433487 ANP32A-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 AL691432.2 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patients Regulation Bioinformatics Analysis We identified and independently verified the ATG (AL691432.2, MMP2-AS1, AC124067.2, CRNDE, ABALON, AL161431.1, NKILA) in NSCLC patients and found that immune regulation in the tumor microenvironment is closely related to this gene. No 34849558 ANKS1A CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ANKRD44-AS1 LncRNA Homo sapiens COVID-19 126 blood samples Expression(highly expressed) Bioinformatics Analysis Upon further investigation on an individually selected lncRNA level, some lncRNA genes were significantly enriched in the COVID-19/ICU, while some were enriched in the COVID-19/non-ICU group (Figures 5c and 5d). Selected lncRNAs are presented as violin plots depicting upregulation of LINC02207, AC020636.1, AC243967.2, LINC01127, AC00727.1 and AC092746.1 in the COVID-19/ICU group, whereas those enriched in the COVID-19/non-ICU group include LINC02084, LINC02446, LINC00861, AC015911.3, LINC01871 and ANKRD44-AS1 with ANOVA p values of <0.0001. No 33898797 ANKRD36BP2 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)70) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 ANKRD27 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ANKRD26P4 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 852 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ANKRD26P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 984 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ANKRD26 CircRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR//circRNA-seq The top 5 up- and downregulated circRNAs in patients with are listed in Table IV. No 32765789 ANKRD20A5P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ANKRD20A11P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ANGPTL1-3 LncRNA Homo sapiens Multiple Myeloma Bone marrow Expression[highly expressed] qRT-PCR Here, we found that long non-coding RNA ANGPTL1-3 which located in 1q region was overexpressed in MM. Lnc-ANGPTL1-3 expression was correlated with MM International Staging System (ISS) and overall survival. No 31103265 ANGPTL1-3 LncRNA Homo sapiens Multiple Myeloma MM patients Expression(highly expressed) qRT-PCR Lnc-ANGPTL1-3 was upregulated while miR-30a was downregulated in MM patients compared to healthy donors (both P < 0.001), then a negative correlation between lnc-ANGPTL1-3 and miR-30a was found in MM patients (P < 0.001) instead of in health donors (P = 0.188). Besides, lnc-ANGPTL1-3 predicted lower complete response (CR) (P = 0.034), poor PFS (P = 0.016) and OS (P = 0.041) but not objective response rate (ORR) (P = 0.128). However, miR-30a forecasted higher CR (P = 0.013), prolonged PFS (P = 0.014), and OS (P = 0.045) but not ORR (P = 0.407). No 35617291 ANAPC7 CircRNA Homo sapiens Leukemia, Myeloid, Acute bone marrow interaction[MiR-181 Family] qRT-PCR Quantitative reverse transcription PCR showed that circ-ANAPC7 was significantly upregulated in AML. These findings show that circ-ANAPC7 is a promising biomarker for AML, and that it might participate in AML pathogenesis by acting as a sponge for the miR-181 family. No 29969755 ANAPC1P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 926 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ANAPC13-202 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 AMPH-206 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AMOTL2-210 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[highly expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 AMD1-207 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 ALS2CL LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ALPHA LncRNA Homo sapiens chikungunya alphavirus chikungunya virus Regulation qRT-PCR//Transfection//RNA-seq//IF Using high-throughput genetic screening, we identified a cytoplasmic antiviral lncRNA that we named antiviral lncRNA prohibiting human alphaviruses (ALPHA), which is transcriptionally induced by alphaviruses and functions independently of IFN to inhibit the replication of CHIKV and its closest relative, O'nyong'nyong virus (ONNV), but not other viruses. Furthermore, we showed that ALPHA interacts with CHIKV genomic RNA and restrains viral RNA replication. Together, our findings reveal that ALPHA and potentially other lncRNAs can mediate non-canonical antiviral immune responses against specific viruses. No 36167073 ALOX15P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ALOX12P2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ALMS1-IT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ALMS1-IT1 LncRNA Homo sapiens Colonic Neoplasms COAD tissues Expression(highly expressed) RNA-seq Increased ALMS1-IT1 expression in COAD was associated with N stage (P < .001), M stage (P = .003), Pathologic stage (P = .002), and Primary therapy outcome (P = .009). Increased ALMS1-IT1 expression in COAD was associated with N stage (P < .001), M stage (P = .003), Pathologic stage (P = .002), and Primary therapy outcome (P = .009).High ALMS1-IT1 expression predicted a poorer overall-survival (P = .005) and poorer progression-free interval (PFI) (P = .012), and ALMS1-IT1 expression was independently correlated with PFI in COAD patients (hazard ratio (HR) :1.468; 95% CI: 1.029-2.093; P =.034) (HR: 1.468; 95% CI: 1.029-2.093; P = .034). No 36281164 ALG3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ALG1L9P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ALG1L12P LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 642 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ALDH3A2-210 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 AL928742.12 LncRNA Homo sapiens Multiple Sclerosis peripheral blood mononuclear cells Expression[lower expressed] qRT-PCR Our results showed that in relapsing MS patients, compared to remitting MS patients and healthy controls, lncRNA RP11-530C5.1 was up-regulated while AL928742.13 was down-regulated. No 31576494 AC020928.1 LncRNA Homo sapiens Neuroblastoma Three independent gene expression datasets Regulation qRT-PCR//Western Blot Four autophagy-related lncRNAs (AL356599.1, AC022075.1, AC020928.1 and LINC02076) were found to be with the best prognostic value and integrated into a four-lncRNA risk signature for predicting PFS of NB patients. The four-lncRNA signature significantly stratify NB patients into two risk groups, with high-risk group has significantly poorer PFS than the low-risk group. No 36530992 AC018754.1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC016697.6 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)27) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 hsa_circ_000780 CircRNA Homo sapiens Stomach Neoplasms 82 GC malignant and adjacent tissue samples Expression [lower expressed] qRT-PCR//Microarray Hsa_circ_000780 was significantly downregulated in 80.77% of GC tissue samples, with levels in GC tissue samples correlating with tumor size, tumor stage, T stage, venous invasion, carcinoembryonic antigen amounts, and carbohydrate antigen 19-9 levels. Strikingly, this circRNA was found in the gastric fluid of patients with early and advanced GC. Hsa_circ_000780 was significantly downregulated in 80.77% of GC tissue samples, with levels in GC tissue samples correlating with tumor size, tumor stage, T stage, venous invasion, carcinoembryonic antigen amounts, and carbohydrate antigen 19-9 levels. No 34838011 hsa_circ_0005092 CircRNA Homo sapiens Stomach Neoplasms GC patients with different RFS Expression [highly expressed] qRT-PCR//RNA-seq//Bioinformatics Analysis We found two circRNAs (hsa_circ_0005092 and hsa_circ_0002647) that highly expressed in GC patients with good prognoses, and subsequently established a predictive model for postoperative recurrence and prognosis evaluation, named circPanel. Patients with circPanellow might have shorter recurrence-free survival (RFS) and overall survival (OS). No 34600555 hsa_circ_0002647 CircRNA Homo sapiens Stomach Neoplasms GC patients with different RFS Expression [highly expressed] qRT-PCR//RNA-seq//Bioinformatics Analysis We found two circRNAs (hsa_circ_0005092 and hsa_circ_0002647) that highly expressed in GC patients with good prognoses, and subsequently established a predictive model for postoperative recurrence and prognosis evaluation, named circPanel. Patients with circPanellow might have shorter recurrence-free survival (RFS) and overall survival (OS). No 34600555 hsa_circ_0001874 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression [lower expressed] qRT-PCR//Bioinformatics Analysis Our data showed that as an indicator, hsa_circ_0001874 expression was significantly decreased in 78.02% (71/91) of the GC patients. Combined with clinicopathological factors, the hsa_circ_0001874 level was strongly associated with cell differentiation (p < 0.001), tumor stage (p = 0.005), invasion (p = 0.024), lymphatic metastasis (p = 0.023), and CEA level (p < 0.001) in GC tissues. No 34028890 hsa_circ_0007507 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression(highly expressed) qRT-PCR//Luciferase Report Assay The level of expression of hsa_circ_0007507 in GC tissues was up-regulated (p = 0.0121), which was consistent with the results of circRNA sequencing. Exonuclease digestion assay and actinomycin D confirmed that hsa_circ_0007507 had a stable structure and a longer half-life. The expression of serum hsa_circ_0007507 in GC patients significantly decreased after surgery (p = 0.001). The level of expression of hsa_circ_0007507 in GC tissues was up-regulated (p = 0.0121), which was consistent with the results of circRNA sequencing. Exonuclease digestion assay and actinomycin D confirmed that hsa_circ_0007507 had a stable structure and a longer half-life. In the analysis of organ specificity experiments, serum hsa_circ_0007507 did not have specificity for patients with colorectal cancer (p = 0.5319), thyroid cancer (p = 0.5422), or breast cancer (p = 0.5178). No 34595108 circASHL2 CircRNA Homo sapiens Stomach Neoplasms GC patients Regulation qRT-PCR//Bioinformatics Analysis//Microarray Nine miRNAs and eight lncRNAs were obtained from the microarray analysis. Six miRNAs (miR-550a-5p, miRNA-936, miR-1306-3p, miR-3185, miR-6083, miR-6792-3p) and three lncRNAs (lnc-MB21D1-3:5, lnc-PSCA-4:2 and lnc-ABCC5-2:1) were abnormally expressed in circulating and tissue samples compared with normal control (NC), which was closely related to clinical pathology and survival time of GC patients; circRNA sequencing and qRT-PCR revealed four circRNAs (circASHL2, circCCDC9, circNHSL1 and cirMLLT10) were abnormally expressed in GC tissues and parts of them were negative relationship with their predicted binding miRNAs. No 34295803 circCCDC9 CircRNA Homo sapiens Stomach Neoplasms GC patients Regulation qRT-PCR//Bioinformatics Analysis//Microarray Nine miRNAs and eight lncRNAs were obtained from the microarray analysis. Six miRNAs (miR-550a-5p, miRNA-936, miR-1306-3p, miR-3185, miR-6083, miR-6792-3p) and three lncRNAs (lnc-MB21D1-3:5, lnc-PSCA-4:2 and lnc-ABCC5-2:1) were abnormally expressed in circulating and tissue samples compared with normal control (NC), which was closely related to clinical pathology and survival time of GC patients; circRNA sequencing and qRT-PCR revealed four circRNAs (circASHL2, circCCDC9, circNHSL1 and cirMLLT10) were abnormally expressed in GC tissues and parts of them were negative relationship with their predicted binding miRNAs. No 34295803 circNHSL1 CircRNA Homo sapiens Stomach Neoplasms GC patients Regulation qRT-PCR//Bioinformatics Analysis//Microarray Nine miRNAs and eight lncRNAs were obtained from the microarray analysis. Six miRNAs (miR-550a-5p, miRNA-936, miR-1306-3p, miR-3185, miR-6083, miR-6792-3p) and three lncRNAs (lnc-MB21D1-3:5, lnc-PSCA-4:2 and lnc-ABCC5-2:1) were abnormally expressed in circulating and tissue samples compared with normal control (NC), which was closely related to clinical pathology and survival time of GC patients; circRNA sequencing and qRT-PCR revealed four circRNAs (circASHL2, circCCDC9, circNHSL1 and cirMLLT10) were abnormally expressed in GC tissues and parts of them were negative relationship with their predicted binding miRNAs. No 34295803 hsa_circ_0001020 CircRNA Homo sapiens Stomach Neoplasms GC cell lines, GC tissue samples, and even in plasma Expression(highly expressed) qRT-PCR Our tests found that hsa_circ_0001020 was significantly upregulated in GC cell lines, GC tissue samples, and even in plasma. High hsa_circ_0001020 expression levels in GC tissues were significantly associated with distal metastasis and blood carbohydrate antigen 19-9 (CA19-9). GC patients with high hsa_circ_0001020 had a lower overall survival and disease-free survival time than the low levels. No 34424459 hsa_circ_0006470 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression(lower expressed) qRT-PCR Compared with adjacent normal tissues, the expression of hsa_circ_0006470 in GC tissues was significantly lower. The expression levels of hsa_circ_0006470 in different TNM stages and different invasion degrees were significantly different. The area under the ROC curve was 0.783, with sensitivity and specificity 0.725 and 0.750, respectively. No 34165822 hsa_circ_0003195 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and plasma Expression(lower expressed) qRT-PCR The expression of hsa_circ_0003195 was down-regulated in gastric cancer tissues and plasma from patients with gastric cancer. The expression level of hsa_circ_0003195 was correlated with differentiation, TNM stages, lymphatic metastasis, and distal metastasis. No 34773528 hsa_circ_0015286 CircRNA Homo sapiens Stomach Neoplasms GC tissue, plasma and cancer cells Expression(highly expressed) qRT-PCR We detected that hsa_circ_0015286 was remarkably highly expressed in GC tissue, plasma and cancer cells compared with normal controls. Exosomal hsa_circ_0015286 expression was closely associated with tumor size, TNM stage and lymph node metastasis.Overall survival of patients with low hsa_circ_0015286 expression was longer than those with high expression. No 35755416 hsa_circ_0007396 CircRNA Homo sapiens Stomach Neoplasms GEO database Interaction(miR-767-3p-CHD4 axis) IHC//Microarray We identified an important hsa_circ_0007396-miR-767-3p-CHD4 axis, which is associated with GC proliferation and carcinogenesis, and may represent a promising therapeutic target for the future cure of GC. No 36636050 hsa_circ_0000211 CircRNA Homo sapiens Stomach Neoplasms 71 gastric tissue samples Regulation qRT-PCR Overall, our results showed that hsa_circ_0000211, hsa_circ_0000284 and hsa_circ_0004771 presented equivalent expression profiles when analyzed by different methods (RNA-Seq and RT-qPCR) and different types of samples (tissue and blood). Further, functional enrichment results identified important signaling pathways related to GC. No 35054834 hsa_circ_0000284 CircRNA Homo sapiens Stomach Neoplasms 71 gastric tissue samples Regulation qRT-PCR Overall, our results showed that hsa_circ_0000211, hsa_circ_0000284 and hsa_circ_0004771 presented equivalent expression profiles when analyzed by different methods (RNA-Seq and RT-qPCR) and different types of samples (tissue and blood). Further, functional enrichment results identified important signaling pathways related to GC. No 35054834 hsa_circ_0004771 CircRNA Homo sapiens Stomach Neoplasms 71 gastric tissue samples Regulation qRT-PCR Overall, our results showed that hsa_circ_0000211, hsa_circ_0000284 and hsa_circ_0004771 presented equivalent expression profiles when analyzed by different methods (RNA-Seq and RT-qPCR) and different types of samples (tissue and blood). Further, functional enrichment results identified important signaling pathways related to GC. No 35054834 hsa_circ_0086720 CircRNA Homo sapiens Stomach Neoplasms gastric carcinogenesis Expression(lower expressed) qRT-PCR Hsa_circ_0086720 was found to be downregulated in gastric carcinogenesis, and tissue hsa_circ_0086720 was negatively associated with perineural invasion, Borrmann type, disease-free survival, and overall survival. Hsa_circ_0086720 was stable in circulating plasma and was actively secreted by cells in gastric carcinogenesis. Hsa_circ_0086720 was found to be downregulated in gastric carcinogenesis, and tissue hsa_circ_0086720 was negatively associated with perineural invasion, Borrmann type, disease-free survival, and overall survival. No 35334500 hsa_circ_0017252 CircRNA Homo sapiens Stomach Neoplasms GC cells Regulation(macrophage M2-like polarization) Western Blot//CCK8//FISH//qRT-PCR//Luciferase Report Assay//ELISA//Transwell Assay//IF These investigations collectively revealed that miR-17-5p is a target of the circRNA hsa_circ_0017252 and hsa_circ_0017252 is significantly downregulated in GC tissues. In addition, the overexpression of hsa_circ_0017252 inhibited GC cell migration by sponging of miR-17-5p, and GC cell-secreted exosomal hsa_circ_0017252 effectively inhibited macrophage M2-like polarization, which in turn suppressed GC cell invasion. Notably, exosomes containing hsa_circ_0017252 also suppressed GC tumor growth in vivo. Thus, our data suggest that the overexpression of hsa_circ_0017252 suppresses GC malignancy by sponging miR-17-5p. In addition, exosomal hsa_circ_0017252 excreted from GC cells attenuated GC progression by suppressing macrophage M2-like polarization. These findings improve our basic understanding of GC and open a novel avenue for developing more effective GC treatments. No 35796939 hsa_circ_0002874 CircRNA Homo sapiens Stomach Neoplasms Peripheral Blood of Patients Expression(highly expressed) qRT-PCR The expression level of hsa_circ_0002874 mean (interquartile range [IQR]) in the plasma of patients with GC, patients with benign gastric lesions, and healthy individuals was 3.482 (IQR, 1.524-9.048), 1.261 (IQR, 0.817-2.000), and 1.00 (IQR, 0.726-1.382), respectively, whereas there was no significant difference between the latter 2 groups. The plasma expression level of hsa_circ_0002874 was significantly correlated with tumor stage (U = 234.0; P < .001) and lymph node metastasis (U = 240.0; P < .001). No 34388244 circSOBP CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression(lower expressed) qRT-PCR Decreased circSOBP RNA accumulation was observed in GC tissues compared to normal tissue samples. Decreased plasma circSOBP accumulation was only observed in GC patients, but not other patients, compared to HCs. With plasma circSOBP as a biomarker, GC patients were separated from other patients and HCs. Patients with high plasma or tissue levels of circSOBP showed better survival conditions. No 35993263 circSNTB2 CircRNA Homo sapiens Stomach Neoplasms cell line Interaction(miR-6938-5p/G0S2 and PDCD4) Microarray Taken together, our findings demonstrated that circSNTB2 plays an essential role in gastric cancer by regulating miR-6938-5p through G0S2 and PDCD4 genes. CircSNTB2 could be a promising biomarker for GC diagnosis and targeted therapy. No 36366842 hsa_circ_0061265 CircRNA Homo sapiens Stomach Neoplasms GC cells Interaction( miRNA-885-3p/AURKA ) RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Transwell Assay In vitro cell experiment demonstrated significantly upregulated circ_0061265 and AURKA, but downregulated miR-885-3p in GC. Moreover, circ_0061265 promoted the occurrence of GC by competitively binding to miRNA-885-3p to regulate AURKA expression. No 36064409 hsa_circ_0007707 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell Interaction(circ-0007707/miR-429/PDGFD Pathway ) qRT-PCR//Western Blot In gastric cancer, the circ-0007707/miR-429/PDGFD pathway had a differential expression. The results demonstrated that the pathway could regulate the progression and immune microenvironment of gastric cancer by modulating the immune-gene signature, which included two immune genes (TAB1 and CXCR4). Moreover, the low-risk group patients had better survival. No 35509844 hsa_circ_0067514 CircRNA Homo sapiens Stomach Neoplasms gastric cancer patients and cancer cells Interaction(miR-654-3p/LATS2 axis) CCK8//qRT-PCR Here, we found that circ_0067514 was decreased in gastric cancer patients and cancer cells. Overexpression of circ_0067514 blocked proliferation, invasion, and glycolysis of gastric cancer cells. Besides, circ_0067514 regulated large tumor suppressor kinase 2 (LATS2) expression by absorbing microRNA (miR)-654-3p. Furthermore, circ_0067514 modulated gastric cancer aggressive behaviors and glycolysis via miR-654-3p/LATS2 axis. The circ_0067514 expression was correlated with gastric cancer overall survival, lymph node metastasis, tumor, node, metastasis (TNM) stage, and histological differentiation. No 35818964 hsa_circ_0001481 CircRNA Homo sapiens Breast Neoplasms cell line Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002. No 30810051 hsa_circ_0000646 CircRNA Homo sapiens Breast Neoplasms cell line Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000003. No 30810051 hsa_circ_0001006 CircRNA Homo sapiens Breast Neoplasms cell line Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000004. No 30810051 hsa_circ_0000732 CircRNA Homo sapiens Breast Neoplasms cell line Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000005. No 30810051 hsa_circ_0001910 CircRNA Homo sapiens Breast Neoplasms cell line Expression[highly expressed] qRT-PCR//RNA-seq The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000006. No 30810051 hsa_circ_0008285 CircRNA Homo sapiens Breast Neoplasms cell line Expression[lower expressed] qRT-PCR//RNA-seq The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000007. No 30810051 hsa_circ_001888 CircRNA Homo sapiens Stomach Neoplasms GC cell lines, tissues, and plasma samples Expression [lower expressed] qRT-PCR In this study, hsa_circ_001888 was first found to be significantly downregulated in GC cell lines (AGS and MKN-45), tissues, and plasma samples compared to control samples. Clinicopathological features showed that the expression of hsa_circ_001888 in GC tissues was associated with differentiation and in GC plasma linked with serum CEA and CA19-9 levels. No 34398999 hsa_circ_0021087 CircRNA Homo sapiens Stomach Neoplasms GC tissues, cells and plasma Expression[lower expressed] qRT-PCR Hsa_circ_0021087 and hsa_circ_0005052 were both downregulated in GC tissues, cells and plasma by RTq-PCR. No 32154178 hsa_circ_0001944 CircRNA Homo sapiens Breast Neoplasms cell line Expression[lower expressed] qRT-PCR//RNA-seq The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000009. No 30810051 hsa_circ_0005051 CircRNA Homo sapiens Stomach Neoplasms GC tissues, cells and plasma Expression[lower expressed] qRT-PCR Hsa_circ_0021087 and hsa_circ_0005051 were both downregulated in GC tissues, cells and plasma by RTq-PCR. No 32154178 hsa_circ_0092306 CircRNA Homo sapiens Stomach Neoplasms Interaction[miR-197-3p/PRKCB] RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//MTT//RNA-seq//Luciferase Report Assay//Transwell Assay hsa_circ_0092306 was upregulated in GC tissues and GC cells, and promoted GC development in MKN-45 cells. hsa_circ_0092306 inhibited tumor suppressor miR-197-3p expression but promoted tumor promotor protein kinase C beta (PRKCB) expression in MKN-45 cells. hsa_circ_0092306 and PRKCB had a common target (miR-197-3p) and were negatively related to miR-197-3p expression. hsa_circ_0092306 promoted the development of GC by regulating the pathway of miR-197-3p/PRKCB in MKN-45 cells. No 31689616 hsa_circ_0001132 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 hsa_circ_0000254 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 hsa_circ_0036273 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 hsa_circ_0035890 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 hsa_circ_0063557 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 hsa_circ_0026367 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 hsa_circ_0026359 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 hsa_circ_0026369 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 hsa_circ_0026361 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 hsa_circ_0026365 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 circHIPK3 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR Our results showed that the expression of cir_ITCH and circHIPK3 were significantly downregulated in GC tumoral tissues compared with their paired adjacent nonneoplastic counterparts. No 30866608 hsa_circ_0001821 CircRNA Homo sapiens Stomach Neoplasms GC tissues,blood Expression[lower expressed] qRT-PCR Further validation disclosed that hsa_circ_0001821 was significantly downregulated in the 80 pairs of GC tissues and 30 whole-blood specimens obtained from the GC patients. Clinicopathological parameter analysis showed that hsa_circ_0001821 was negatively correlated with tumor depth (r = -0.255, P = 0.022) and lymph node metastasis (r = -0.235, P = 0.036). Area under the curve (AUC) analysis showed that the diagnostic efficiency of circulating hsa_circ_0001821 in distinguishing GC patients was higher than that in GC tissues (0.872, 95%CI: 0.767-0.977 vs. 0.792, 95%CI: 0.723-0.861). No 31616472 hsa_circ_0000096 CircRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR The positive expression rates of hsa_circ_002059, hsa_circ_0000096 and hsa_circ_0001895 were 70.8%, 47.9%, 75.0% in case group, slightly higher than those in control group (58.3%, 31.3%, 60.4%), although P values were all more than 0.05. No 32062910 hsa_circ_0001895 CircRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR The positive expression rates of hsa_circ_002059, hsa_circ_0000096 and hsa_circ_0001895 were 70.8%, 47.9%, 75.0% in case group, slightly higher than those in control group (58.3%, 31.3%, 60.4%), although P values were all more than 0.05. No 32062910 hsa_circ_002059 CircRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR The positive expression rates of hsa_circ_002059, hsa_circ_0000096 and hsa_circ_0001895 were 70.8%, 47.9%, 75.0% in case group, slightly higher than those in control group (58.3%, 31.3%, 60.4%), although P values were all more than 0.05. No 32062910 hsa_circ_0067582 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[lower expressed] qRT-PCR Compared with healthy control tissues, both hsa_circ_0067582 and hsa_circ_0005758 were significantly decreased in GC tissues. No 31328820 hsa_circ_0005758 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[lower expressed] qRT-PCR Compared with healthy control tissues, both hsa_circ_0067582 and hsa_circ_0005758 were significantly decreased in GC tissues. No 31328820 hsa_circ_0005556 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[lower expressed] qRT-PCR hsa_circ_0005556 was significantly downregulated in GC tissues contrasted with adjacent normal tissues (n = 100, p < 0.001). The areas under the ROC curve (AUC) of hsa_circ_0005556 were up to 0.773, while 64% sensitivity and 82% specificity, respectively. Moreover, its expression levels were significantly associated with differentiation (p = 0.001), TNM stage (p = 0.013), and lymphatic metastasis (p = 0.039). GC patients of high hsa_circ_0005556 levels had a longer overall survival (OS) than those of the low group (p = 0.047). No 31827632 hsa_circ_102958 CircRNA Homo sapiens Stomach Neoplasms gastric tissue and cell Expression[highly expressed] qRT-PCR In this study, we analyzed 30 patients and found that hsa_circRNA_102958 was significantly overexpressed in gastric cancer tissues compared with paired adjacent normal tissues. Clinicopathological features showed that hsa_circRNA_102958 level in GC tissues was positively associated with TNM stage (p= 0.032). No 30689557 hsa_circ_0001811 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[lower expressed] qRT-PCR Hsa_circ_0001811 was found to be lowly expressed in gastric cancer tissues and plasma from patients with gastric cancer. The expression level of hsa_circ_0001811 in gastric cancer tissue correlated with carcinoembryonic antigen (CEA) (P = .0347), tissue differentiation (P = .0138), and lymph node metastasis (P = .0234), while plasma hsa_circ_0001811 level was related to carbohydrate antigen (CA19-9) (P = .0278), lymph node metastasis (P = .0469), distant metastasis (P = .0384), and age (P = .0085). No 33159345 hsa_circ_0004771 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR The expression level of circ_0004771 is up-regulated in GC tissues, which is consistent with circRNA sequencing result (P=0.0001). No 33116589 hsa_circ_0141633 CircRNA Homo sapiens Stomach Neoplasms serum and tissue Expression[highly expressed] qRT-PCR The level of serum and tissue has_circ_0141633 in GC patients was significantly higher than that in controls. The level of serum has_circ_0141633 was significantly increased according to the malignant characteristics of tumor diameter, differentiation, lymph node metastasis, and TNM stage. The median survival time of GC patients with low expression of has_circ_0141633 was longer than that of GC patients with high expression of has_circ_0141633. No 32902223 hsa_circ_0026359 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues/cells Expression[highly expressed] qRT-PCR In this study, circular RNA circ_0026359 was demonstrated to be overexpressed in gastric cancer tissues/cells compared with normal gastric tissues/cells and was overexpressed in CDDP-resistant gastric cancer tissues/cells compared with CDDP-sensitive gastric cancer tissues/cells. No 32855967 hsa_circ_0000520 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cell lines Expression[lower expressed] qRT-PCR//MTT The expression of hsa_circ_0000520 was reduced in gastric cancer tissues and cell lines, and hsa_circ_0000520 in NCI-N87R cells was significantly lower than that of NCI-N87 cells. No 32701211 circDONSON CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Expression[highly expressed] qRT-PCR CircDONSON was elevated in GC tissues and cell lines, especially in DDP-resistant GC tissues and cells. No 32581651 hsa_circ_0026344 CircRNA Homo sapiens Stomach Neoplasms cancer tissues Expression[lower expressed] qRT-PCR In 93 cases of gastric cancer, circ_0026344 in cancer tissues was significantly decreased compared to adjacent non-cancerous tissues, and its level was markedly associated with tumour size, lymph node metastasis, TNM stage, and invasive depth. In 93 cases of gastric cancer, circ_0026344 in cancer tissues was significantly decreased compared to adjacent non-cancerous tissues, and its level was markedly associated with tumour size, lymph node metastasis, TNM stage, and invasive depth. No 32509073 hsa_circ_0006156 CircRNA Homo sapiens Stomach Neoplasms Cancer tissues Expression[lower expressed] qRT-PCR The results of RT-qPCR showed that the expression level of hsa_circ_0006156 was significantly lower in gastric cancer tissues than that in para-carcinoma tissues (p<0.05). The expression level of hsa_circ_0006156 was not correlated with the age and gender of gastric cancer patients (p>0.05) but correlated with the lymph node metastasis (p<0.05), nerve invasion (p<0.05), and degree of tumor differentiation (p<0.05). The expression level of hsa_circ_0006156 was also significantly associated with the progression-free survival (PFS) and overall survival (OS) of patients (p<0.05). No 32271420 circATAD1 CircRNA Homo sapiens Stomach Neoplasms cancerous tissues regulation[miR-140-3p/YY1/PCIF1 signaling axis] RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay Circ-ATAD1 expression was increased in cancerous tissues.For GC cells, circ-ATAD1 increased cell progression by sponging miR-140-3p to upregulate YY1. Additionally, YY1 directly bound to the promoter of PCIF1, thereby activating its transcription. No 32169278 hsa_circ_0000002 CircRNA Homo sapiens Breast Neoplasms cell line Expression[lower expressed] qRT-PCR//RNA-seq The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000008. No 30810051 hsa_circ_005230 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_0000419 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues and cell lines,blood Expression[lower expressed] qRT-PCR Hsa_circ_0000419 levels were significantly decreased in GC cell lines, cancer tissues and plasma from GC patients. GC tissues hsa_circ_0000419 levels were associated with cell differentiation, Borrmann type, overall survival and disease-free survival, whereas plasma hsa_circ_0000419 were significantly correlated with tumor stage, lymphatic and distal metastasis, venous and perineural invasion. No 31810586 hsa_circ_0000987 CircRNA Homo sapiens Breast Neoplasms blood Expression[highly expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0000091 CircRNA Homo sapiens Breast Neoplasms blood Expression[highly expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0008549 CircRNA Homo sapiens Breast Neoplasms blood Expression[highly expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0016601 CircRNA Homo sapiens Breast Neoplasms blood Expression[highly expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0000826 CircRNA Homo sapiens Breast Neoplasms blood Expression[lower expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0072697 CircRNA Homo sapiens Breast Neoplasms blood Expression[lower expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0004587 CircRNA Homo sapiens Breast Neoplasms blood Expression[lower expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0000471 CircRNA Homo sapiens Breast Neoplasms blood Expression[lower expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0007786 CircRNA Homo sapiens Breast Neoplasms blood Expression[lower expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0001417 CircRNA Homo sapiens Breast Neoplasms blood Expression[lower expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0005982 CircRNA Homo sapiens Breast Neoplasms blood Expression[lower expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0001566 CircRNA Homo sapiens Breast Neoplasms blood Expression[lower expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0003823 CircRNA Homo sapiens Breast Neoplasms blood Expression[lower expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 circBACH2 CircRNA Homo sapiens Breast Neoplasms BC tissues Interaction(has-miR-944/HNRNPC axis) CCK8//qRT-PCR//EdU Staining//Western Blot Our findings decipher a novel circRNA-based m6A regulatory mechanism involved in BC progression No 34952600 hsa_circ_0000745 CircRNA Homo sapiens Breast Neoplasms Whole blood specimens were obtained from 129 patients with breast cancer, 19 patients with benign breast tumor and 13 healthy controls Expression [highly expressed] qRT-PCR QRT-PCR validated that circ_0000745, circ_0001531 and circ_0001640 were upregulated in breast cancer, compared with benign tumor and healthy control. ROC curve analysis revealed that circ_0000745, circ_0001531 and circ_0001640 had good diagnostic potential. ROC curve analysis revealed that circ_0000745, circ_0001531 and circ_0001640 had good diagnostic potential. No 34139239 hsa_circ_0001531 CircRNA Homo sapiens Breast Neoplasms Whole blood specimens were obtained from 129 patients with breast cancer, 19 patients with benign breast tumor and 13 healthy controls  Expression [highly expressed] qRT-PCR QRT-PCR validated that circ_0000745, circ_0001531 and circ_0001640 were upregulated in breast cancer, compared with benign tumor and healthy control. ROC curve analysis revealed that circ_0000745, circ_0001531 and circ_0001640 had good diagnostic potential. ROC curve analysis revealed that circ_0000745, circ_0001531 and circ_0001640 had good diagnostic potential. No 34139239 hsa_circ_0001640 CircRNA Homo sapiens Breast Neoplasms Whole blood specimens were obtained from 129 patients with breast cancer, 19 patients with benign breast tumor and 13 healthy controls Expression [highly expressed] qRT-PCR QRT-PCR validated that circ_0000745, circ_0001531 and circ_0001640 were upregulated in breast cancer, compared with benign tumor and healthy control. ROC curve analysis revealed that circ_0000745, circ_0001531 and circ_0001640 had good diagnostic potential. ROC curve analysis revealed that circ_0000745, circ_0001531 and circ_0001640 had good diagnostic potential. No 34139239 circPGR CircRNA Homo sapiens Breast Neoplasms breast cancer cell lines and clinical breast cancer tissue samples Interaction(miR-301a-5p) qRT-PCR circPGR, was required for ER-positive breast cancer cell growth and tumorigenesis. CircPGR was found to be localized in the cytosol of cells and functioned as a competing endogenous RNA (ceRNA) to sponge miR-301a-5p to regulate the expression of multiple cell cycle genes. The clinical relevance of circPGR was underscored by its high and specific expression in ER-positive breast cancer cell lines and clinical breast cancer tissue samples. No 33408778 hsa_circ_0005046 CircRNA Homo sapiens Breast Neoplasms BC tissues and paired adjacent normal tissues Expression [highly expressed] qRT-PCR Our results showed the higher expression levels of hsa_circ_0005046 and hsa_circ_0001791 in BC tissues compared to paired adjacent normal tissues with P value (P < 0.0001) for both circRNAs No 34239561 hsa_circ_0001791 CircRNA Homo sapiens Breast Neoplasms BC tissues and paired adjacent normal tissues Expression [highly expressed] qRT-PCR Our results showed the higher expression levels of hsa_circ_0005046 and hsa_circ_0001791 in BC tissues compared to paired adjacent normal tissues with P value (P < 0.0001) for both circRNAs No 34239561 hsa_circ_0006220 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Interaction(MiR-197-5p) qRT-PCR Hsa_circ_0006220 was found to be significantly downregulated in breast cancer tissues compared to the paired noncancerous tissues by microarray and RT-PCR.Five miRNAs that might be sponged by hsa_circ_0006220 were predicted. MiR-197-5p was significantly downregulated after overexpression of hsa_circ_0006220. The expression of hsa_circ_0006220 was significantly inversely correlated with histological type (P=0.0028) and lymph node metastasis (P=0.0341). The area under the ROC curve (AUC) was 0.706. No 33708563 hsa_circ_0000160 CircRNA Homo sapiens Breast Neoplasms beast cancer tissues Expression(lower expressed) qRT-PCR Circ_0000160 was validated to be downregulated in breast cancer tissues with ALNM compared with those without ALNM. The ROC curve showed the ability of circ_0000160 to distinguish breast cancer tissues with ALNM and those without ALNM, with an area under the curve of 0.7435. Furthermore, bioinformatics analysis revealed that the predicted mRNAs for circ_0000160 may be related to lymph node metastasis. No 35211507 circWWC3 CircRNA Homo sapiens Breast Neoplasms breast cancer cells Regulation(IL-4) Western Blot//H&E Staining//Migration Assay//qRT-PCR//FISH//IF//Microarray//ELISA//IHC//Transwell Assay In the present study, we revealed that circular RNA circWWC3 could up-regulate the expression and secretion of IL-4 in breast cancer cells. Enhanced secretion of IL-4 from breast cancer cells could augment the M2-like polarization of macrophages in TME, which further promotes the migration of breast cancer cells. In addition, increased secretion of IL-4 from breast cancer cells could induce the expression PD-L1 in M2 macrophages. Moreover, up-regulated IL-4 also enhanced the expression of PD-L1 in breast cancer cells, which further facilitates breast cancer immune evasion. Though analyzing the expression of circWWC3, IL-4, PD-L1, and CD163 in 140 cases of breast cancer tissues, we found that high expression of circWWC3 was associated with poor overall survival and disease-free survival of breast cancer patients. Breast cancer patients with circWWC3high/PD-L1high breast cancer cells and CD163high macrophages had a poorer overall survival and disease-free survival. Conclusively, circWWC3 might augment breast cancer progression through promoting M2 macrophage polarization and tumor immune escape via regulating the expression and secretion of IL-4. CircWWC3 might be a potential therapeutic target in breast cancer. we found that high expression of circWWC3 was associated with poor overall survival and disease-free survival of breast cancer patients. No 35996149 hsa_circ_000839 CircRNA Homo sapiens Breast Neoplasms tumors Expression(lower expressed) qRT-PCR//Migration Assay//Cell Viability Assay//Western Blot The expression level of hsa_circ_0005986 and hsa_circ_000839 was lower in the tumor as compared to adjacent tissues. The expression level of hsa_circ_0005986 in the patients who had used hair dye in the last 5 years was significantly lower. No 35098570 hsa_circ_0005986 CircRNA Homo sapiens Breast Neoplasms tumors Expression(lower expressed) qRT-PCR//Migration Assay//Cell Viability Assay//Western Blot The expression level of hsa_circ_0005986 and hsa_circ_000839 was lower in the tumor as compared to adjacent tissues. The expression level of hsa_circ_0005986 in the patients who had used hair dye in the last 5 years was significantly lower. No 35098570 circFGFR3 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues Regulation[AKT and ERK1/2 signaling pathways] Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay Here, we used quantitative real-time polymerase chain reaction to validate that circFGFR3 expression was higher in NSCLC tissues than in the paratumor tissues. Furthermore, our study indicated that the forced circFGFR3 expression promoted NSCLC cell invasion and proliferation. Mechanistically, we found that circFGFR3 promoted NSCLC cell invasion and proliferation via competitively combining with miR-22-3p to facilitate the galectin-1 (Gal-1), p-AKT, and p-ERK1/2 expressions. " Next, we divided the 63 patients into circFGFR3‐high and circFGFR3‐low groExpression[Expression[up-expression]-expression]s. The Kaplan–Meier analysis and logrank test results show that the forced circFGFR3 expression indicated a bad prognosis in NSCLC patients for overall survival and cumulative recurrence after operation (Figure 1c,d). " No 30565694 circCMPK1 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cell lines Interaction[sponging miR-302e] CCK8//qRT-PCR//RNA Pull-Down//Luciferase Report Assay Furthermore, we found that miR-302 was sponged by circular RNA CMPK1 (circ-CMPK1, hsa_circ_0012384), which was remarkably up-regulated in NSCLC and predicted poor prognosis. No 31863641 hsa_circ_0076305 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Lung Cancer tissues,cell lines Expression[highly expressed] qRT-PCR Circ_0076305 was upregulated in NSCLC. No 31647948 Novel_circ_0005280 CircRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tumor tissues Expression[lower expressed] qRT-PCR Novel_circ_0005280 expression was significantly decreased in NSCLC tumor tissues (n=41, obtained via biopsies), compared with adjacent normal tissues (n=27). Novel_circ_0005280 expression was correlated with tumor diameter and age. The area under the receiver-operating characteristic curve, cutoff, sensitivity, and specificity of novel_circ_0005280 were 0.944, 10.23, 85.2%, and 95.1%, respectively. Low novel_circ_0005280 expression was associated with a worse prognosis. No 33447417 hsa_circ_0007386 CircRNA Homo sapiens Breast Neoplasms blood Expression[highly expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0119881 CircRNA Homo sapiens Breast Neoplasms blood Expression[highly expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_103254 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_0003423 CircRNA Homo sapiens Breast Neoplasms blood Expression[highly expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_103552 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_101981 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_063763 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_103253 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_103902 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_002908 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_102736 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_104327 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[highly expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_406225 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_404724 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_406697 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_002873 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_008842 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_047418 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_401033 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_001288 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_104858 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 hsa_circ_001838 CircRNA Homo sapiens Breast Neoplasms cancer and adjacent normal-appearing tissue Expression[lower expressed] Microarray The top 10 upregulated and top 10 downregulated circRNAs for ESCC are listed in Table 1.The top 10 upregulated and top 10 downregulated circRNAs of BC are listed in Table 2. No 30087579 circTADA2A-E5/E6 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Regulation[miR-203a-3p/SOCS3 axis] Western Blot//FISH//qRT-PCR//Luciferase Report Assay//Microarray We detected two circRNAs, circTADA2A-E6 and circTADA2A-E5/E6, which were among the top five differentially expressed circRNAs in breast cancer. They were consistently and significantly decreased in a large cohort of breast cancer patients, and their downregulation was associated with poor patient survival for TNBC. We detected two circRNAs, circTADA2A-E6 and circTADA2A-E5/E6, which were among the top five differentially expressed circRNAs in breast cancer. They were consistently and significantly decreased in a large cohort of breast cancer patients, and their downregulation was associated with poor patient survival for TNBC. No 30787278 hsa_circ_0043278 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[lower expressed] qRT-PCR//Microarray Hsa_circ_0043278 was downregulated 43-fold in breast cancer and was selected for further analysis. The expression of hsa_circ_0043278 was associated with lymph node metastasis and histological type of the patient. Patients with lymph node metastasis have tumors with significantly downregulated expression of hsa_circ_0043278 (P=0.0201). No 33447555 hsa_circ_0104824 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues and plasma Expression[lower expressed] qRT-PCR//Microarray Particularly, hsa_circ_0104824 was significantly down-regulated in the tissues (P = 0.0113). No 33043809 circSMARCA5 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[lower expressed] qRT-PCR Compared to adjacent normal tissues, circSMARCA5 is decreased in breast cancer tissues, contrary to host gene SMARCA5. No 32838810 hsa_circ_002082 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] Microarray Among the three circRNAs, hsa_circRNA_002082 and hsa_circRNA_400031 (Fig. 3a,b) indicated an up-regulated tendency in breast cancer, and p-values was less than 0.05. No 32825956 hsa_circ_400031 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] Microarray Among the three circRNAs, hsa_circRNA_002082 and hsa_circRNA_400031 (Fig. 3a,b) indicated an up-regulated tendency in breast cancer, and p-values was less than 0.05. No 32825956 hsa_circ_104128 CircRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] Microarray Among the three circRNAs, hsa_circRNA_002082 and hsa_circRNA_400031 (Fig. 3a,b) indicated an up-regulated tendency in breast cancer, and p-values was less than 0.05. No 32825956 hsa_circ_0008673 CircRNA Homo sapiens Breast Neoplasms blood Expression[highly expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0008500 CircRNA Homo sapiens Breast Neoplasms blood Expression[highly expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0005260 CircRNA Homo sapiens Breast Neoplasms blood Expression[highly expressed] Microarray Of the top ten up-regulated (hsa_circ_0008673, hsa_circ_0008500, hsa_circ_0005260, hsa_circ_0003423, hsa_circ_0119881, hsa_circ_0000987, hsa_circ_0007386, hsa_circ_0000091, hsa_circ_0016601, and hsa_circ_0008549) and top ten down-regulated (hsa_circ_0000826, hsa_circ_0072697, hsa_circ_0004587, hsa_circ_0000471, hsa_circ_0007786, hsa_circ_0001417, hsa_circ_0005982, hsa_circ_0001566, hsa_circ_0003823, and hsa_circ_0003823) circRNAs from microarray, hsa_circ_0008673 was the most significantly up-regulated circRNA in BC, and represented a good diagnostic value. No 32808350 hsa_circ_0005654 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[lower expressed] qRT-PCR Our data revealed that hsa_circ_0005654 was significantly downregulated in early gastric cancer tissues compared with matched normal mucosae (P< 0.001). No 31640088 hsa_circ_0067582 CircRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR Hsa_circ_0067582 levels were significantly decreased in GC tissues contrasted with adjacent normal tissues (n = 93, P < .001). Moreover, the hsa_circ_0067582 levels were obviously associated with tumor diameter (P = .002) and carbohydrate antigen 19-9 (CA19-9, P = .01). No 31721300 AC015911.3 LncRNA Homo sapiens COVID-19 126 blood samples Expression(highly expressed) Bioinformatics Analysis Upon further investigation on an individually selected lncRNA level, some lncRNA genes were significantly enriched in the COVID-19/ICU, while some were enriched in the COVID-19/non-ICU group (Figures 5c and 5d). Selected lncRNAs are presented as violin plots depicting upregulation of LINC02207, AC020636.1, AC243967.2, LINC01127, AC00727.1 and AC092746.1 in the COVID-19/ICU group, whereas those enriched in the COVID-19/non-ICU group include LINC02084, LINC02446, LINC00861, AC015911.3, LINC01871 and ANKRD44-AS1 with ANOVA p values of <0.0001. No 33898797 AC005256.1 LncRNA Homo sapiens Adenocarcinoma of Lung TCGA(LUAD cancer and normal samples) Regulation Survival Analysis Herein, we identified an eight-lncRNA signature (PR-lncRNA signature, NPSR1-AS1, SATB2-AS1, LINC01090, FGF12-AS2, AC005256.1, MAFA-AS1, BFSP2-AS1, and CPC5-AS1), which contributes to predicting LUAD patient's prognosis risk and survival outcomes. Of them, NPSR1-AS1, SATB2-AS1, FGF12-AS2, and AC005256.1 could be acted as the poor prognosis markers, while LINC01090, MAFA-AS1, BFSP2-AS1, and CPC5-AS1 were treated as the protective factors for survival in LUAD patients. No 34550610 AC005009.2 LncRNA Homo sapiens Schizophrenia human amygdala samples Expression [highly expressed] RNA-seq Additionally, one lncRNA that was overexpressed in SCZ, AC005009.2, also maps to a region previously associated with SCZ based on GWAS and overlapped SCZ-related genes. No 29391398 AC004947.2 LncRNA Homo sapiens Endometrial Neoplasms 301 UCEC patients Regulation Bioinformatics Analysis We detected a novel lncRNA-focus expression signature (LFES) consisting of 11 lncRNAs that were associated with survival based on risk scoring strategy in UCEC. The risk score based on the LFES was able to separate patients of discovery cohort into high-risk and low-risk groups with significantly different overall survival and progression-free survival, and has been successfully confirmed in the validation cohort. No 29304762 AC004943.2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 501 HNSCC tumor samples Regulation Bioinformatics Analysis The Prognostic Signature is based on 10 cuproptosis-related lncRNAs including AC090587.1, AC004943.2, TTN-AS1, AL162458.1, AC106820.5, AC012313.5, AL132800.1, WDFY3-AS2, CDKN2A-DT, and AL136419.3. The results of overall survival, risk score distribution, and survival status in the low-risk group were better than those in the high-risk group. In addition, all immune checkpoint genes involved were significantly different between the two risk groups (p < 0.05). The risk score was positively correlated with Eosinophils. M0 and M2 phenotype macrophages, mast cells activated, NK cells activated, and negatively related with B cells naive, mast cells resting, plasma cells, CD8T cells, T cells follicular helper, T cells regulatory (Tregs). No 35942287 AC004938.5 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)75) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 AC004791.2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 AC004540.5 LncRNA Homo sapiens Neuroblastoma Neuroblastoma tissues Expression[Expression[highly expressed]-expression] ChIP-seq//RNA-seq Differential analysis revealed nine significantly differentially expressed (more than 2-fold change with corrected p-value) lncRNAs between tumor cells and matched MNCs. Of these, RFPL1S (p = 0.0001), PPP1R26-AS1 (p = 0.03), RP11-439E19.3 (p = 1.24 × 10–6), CASC15 (p = 1.6 × 10–7), AC004540.5 (p = 0.0002), and CTD-2881E23.2 (p = 1.6 × 10–9) were found to be significantly Expression[up-expression]regulated (Figure 1B), while USP3-AS1 (p = 1.78 × 10–6), CHRM3-AS2 (p = 0.003) and RP6-99M1.2 (p = 0.002) were significantly downregulated (Figure 1C). No 31920530 AC004475.1-213 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC004160.1 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[lower expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 AC004012.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 AC003991.3 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 AC003092.1 LncRNA Homo sapiens Glioblastoma 161 glioblastoma multiforme (GBM) samples Regulation Bioinformatics Analysis Our study indicates that AC003092.1 is related to glioma-immunosuppressive microenvironment, and these results offer innovative sights into GBM immune therapy. No 33815468 AC002546.1-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC002480.5 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 AC002454.1 LncRNA Homo sapiens acute leukemia bone marrow cells Expression[highly expressed] qRT-PCR Among these up-regulated lncRNA, the difference of AC002454.1 expression was most significant in ALL and AML children (P＜0.05, P＜0.01). No 33067933 ABCC6 LncRNA Homo sapiens Breast Neoplasms breast cancer tissues Expression[highly expressed] qRT-PCR Our data revealed a significant upregulation (P < 0.001) of ARA in breast and liver tumor tissues, in comparison to same patients non-tumor marginal samples. No 30367404 ABCC6 LncRNA Homo sapiens Breast Neoplasms Breast Cancer tissues Expression[highly expressed] qRT-PCR Our data showed a significant upregulation of ARA and ZEB2NAT lncRNAs in tumor tissues compared to NATs (p <0.001; p = 0.021, respectively). ARA and ZEB2NAT expression were observed to be significantly associated with tumor grade, nuclear grade, tumor stages, and lymph node metastasis (p <0.05). Additionally, ARA expression was significantly correlated with breastfeeding status (p = 0.027). No 32921528 ABCC6 LncRNA Homo sapiens Liver Neoplasms liver cancer tissues Expression[highly expressed] qRT-PCR Our data revealed a significant upregulation (P < 0.001) of ARA in breast and liver tumor tissues, in comparison to same patients non-tumor marginal samples. No 30367404 ABCA17P LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ABALON LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC patients Regulation Bioinformatics Analysis We identified and independently verified the ATG (AL691432.2, MMP2-AS1, AC124067.2, CRNDE, ABALON, AL161431.1, NKILA) in NSCLC patients and found that immune regulation in the tumor microenvironment is closely related to this gene. No 34849558 AB007962 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[lower expressed] qRT-PCR In conclusion, it was determined that the expression level of AB007962 was significantly reduced, compared with matched NATs in GC tissues (P=0.003). Survival analysis indicated that patients with intestinal-type GC with a reduced expression of AB007962 had a reduced prognosis, compared with those with an increased expression. No 30214597 AARS1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 AADACL2-AS1 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[lower expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 A2M-AS1 LncRNA Homo sapiens COVID-19 COVID-19 patients Expression(lower expressed) qRT-PCR Results revealed the decreased expression of A2M-AS1 and FLVCR1 in COVID-19 patients. Additionally, they showed the increased expression of DBH-AS1, FLVCR1-DT, and NCBP2AS2. Both FLVCR1-DT and NCBP2AS2 showed a positive correlation with interleukin-6 (IL-6). DBH-AS1 and FLVCR1-DT had a significant association with mortality, complications, and mechanical ventilation. A significant negative correlation was found between A2M-AS1 and NCBP2AS2-1 and between FLVCR1 and FLVCR1-DT. No 36359290 A1BG-AS1 LncRNA Homo sapiens Breast Neoplasms TCGA(1,104 tumor samples and 292 normal samples) Regulation Bioinformatics Analysis In total, five metabolism-related lncRNAs were enrolled to establish prognostic signatures. Further analysis demonstrated that the signature was an independent prognostic factor for BC. No 34254565 91H LncRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR Our data revealed that the expression levels of lncRNAs 91H, PVT-1 and MEG3 were significantly higher in plasma samples from CRC patients than in those from non-cancerous controls. No 30978169 7SK LncRNA Homo sapiens Sepsis blood Expression[highly expressed] qRT-PCR//RNA-seq The top 20 dysregulated lncRNAs are summarized in Table ?Table2.2. No 33327229 52094-1 LncRNA Homo sapiens Arthritis, Gouty blood Expression[lower expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 37475-1 LncRNA Homo sapiens Arthritis, Gouty blood Expression[lower expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 326C3.7 LncRNA Homo sapiens Spondylitis, Ankylosing whole blood cells from 5 AS patients and 3 healthy individuals Regulation qRT-PCR We identified lncRNA 122K13.12 and lncRNA 326C3.7 among 205 lncRNAs differentially expressed between AS patients and healthy humans. No 34746233 AC005165.1-202 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC005332.5 LncRNA Homo sapiens Carcinoma, Hepatocellular Regulation Survival Analysis Classification analysis developed a three-lncRNA signature of AC005332.5, ELF3-AS1 and LINC00665, which was demonstrated to be the most discriminatory with an AUC (Area under the curve) value of 0.913 (95% CI: 0.8610-0.9665) and verified in validation patients. The expression levels of AC005332.5, ELF3-AS1 and LINC00665 were significantly changed with different tumor stages or grades. Survival analysis revealed that AC005332.5, ELF3-AS1 and LINC00665 were highly associated with the prognosis of overall survival. Additionally, the lncRNA signature yielded statistical significance to predict clinical outcomes independently from other clinical variables in validation patients, as suggested in the multivariate Cox hazards analysis. Conclusively, a three-lncRNA signature of AC005332.5, ELF3-AS1 and LINC00665 may serve as an excellent diagnostic biomarker for HBV-related HCC and potential prognostic significance for HBV-related HCC sufferers. Classification analysis developed a three-lncRNA signature of AC005332.5, ELF3-AS1 and LINC00665, which was demonstrated to be the most discriminatory with an AUC (Area under the curve) value of 0.913 (95% CI: 0.8610-0.9665) and verified in validation patients.The expression levels of AC005332.5, ELF3-AS1 and LINC00665 were significantly changed with different tumor stages or grades.Survival analysis revealed that AC005332.5, ELF3-AS1 and LINC00665 were highly associated with the prognosis of overall survival. Additionally, the lncRNA signature yielded statistical significance to predict clinical outcomes independently from other clinical variables in validation patients, as suggested in the multivariate Cox hazards analysis No 35802466 122K13.12 LncRNA Homo sapiens Spondylitis, Ankylosing whole blood cells from 5 AS patients and 3 healthy individuals Regulation qRT-PCR We identified lncRNA 122K13.12 and lncRNA 326C3.7 among 205 lncRNAs differentially expressed between AS patients and healthy humans. No 34746233 AC005394.2-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC015908.2-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC012501.2 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 AC012368.1-211 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC012313.5 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 501 HNSCC tumor samples Regulation Bioinformatics Analysis The Prognostic Signature is based on 10 cuproptosis-related lncRNAs including AC090587.1, AC004943.2, TTN-AS1, AL162458.1, AC106820.5, AC012313.5, AL132800.1, WDFY3-AS2, CDKN2A-DT, and AL136419.3. The results of overall survival, risk score distribution, and survival status in the low-risk group were better than those in the high-risk group. In addition, all immune checkpoint genes involved were significantly different between the two risk groups (p < 0.05). The risk score was positively correlated with Eosinophils. M0 and M2 phenotype macrophages, mast cells activated, NK cells activated, and negatively related with B cells naive, mast cells resting, plasma cells, CD8T cells, T cells follicular helper, T cells regulatory (Tregs). No 35942287 AC012063.1-209 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC011747.4 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 AC011443.1 LncRNA Homo sapiens Coronary Disease GEO Expression(highly expressed) qRT-PCR Next, by constructing a logistic stepwise regression prediction model for 38 DElncRNAs, we screened two hub lncRNAs AC010082.1 and AC011443.1 (p < 0.05). The sensitivity, specificity, and area under the curve were 98.41%, 100%, and 0.995, respectively, for the training set and 93.33%, 91.67%, and 0.983, respectively, for the test set. We further verified the significant upregulation of AC010082.1 (p < 0.01) and AC011443.1 (p < 0.05) in patients with CHD using RT-qPCR in the validation cohort. No 34868268 AC011346.1-212 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC010980.2 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Expression [highly expressed] Survival Analysis In this study, autophagy-related mRNAs-lncRNAs were screened from lung adenocarcinoma and a co-expression network of autophagy-related mRNAs-lncRNAs was constructed by using The Cancer Genome Atlas (TCGA). The univariate and multivariate Cox proportional hazard analyses were used to evaluate the prognostic value of the autophagy-related lncRNAs and finally obtained a survival model composed of 13 autophagy-related lncRNAs. No 33987935 AC010976.2 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[highly expressed] qRT-PCR//Microarray Meanwhile, we observed 347 upregulated lncRNAs and 1765 downregulated lncRNAs in GC samples (Fig. 1D–F). Finally, we identified 1349 circRNAs were up-regulated and 1547 circRNAs were down-regulated in GC compared with normal tissues (Fig. 1G–I). The top 10 differently expressed mRNAs, lncRNAs and circRNAs are listed in Table 1, Table 2, Table 3 by fold change. No 31786464 AC010745.4 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 AC010595.1 LncRNA Homo sapiens Her2-receptor positive breast cancer TCGA Expression [highly expressed] Bioinformatics Analysis The high expression of four core lncRNAs (AC010595.1, AC046168.1, AC069277.1, and AP000904.1) was associated with worse overall survival, while the low expression of LINC00528 and MIR762HG was associated with worse overall survival. The high expression of four core lncRNAs (AC010595.1, AC046168.1, AC069277.1, and AP000904.1) was associated with worse overall survival, while the low expression of LINC00528 and MIR762HG was associated with worse overall survival. The 6-lncRNA model has an especially good predictive power for overall survival (p < 0.0001) and 3-year survival (the area under the curve = 0.980) in HER2-positive breast cancer patients. No 34257572 AC010082.1 LncRNA Homo sapiens Coronary Disease GEO Expression(highly expressed) qRT-PCR Next, by constructing a logistic stepwise regression prediction model for 38 DElncRNAs, we screened two hub lncRNAs AC010082.1 and AC011443.1 (p < 0.05). The sensitivity, specificity, and area under the curve were 98.41%, 100%, and 0.995, respectively, for the training set and 93.33%, 91.67%, and 0.983, respectively, for the test set. We further verified the significant upregulation of AC010082.1 (p < 0.01) and AC011443.1 (p < 0.05) in patients with CHD using RT-qPCR in the validation cohort. No 34868268 AC009975.1 LncRNA Mus musculus estrogen-receptor positive breast cancer HER2+ breast cancer tissues Expression(highly expressed) qRT-PCR//Microarray Our results demonstrated that three lncRNA sets, lncRNA-AL390243.1, POTEH-AS1, and lncRNA-AC009975.1, were up-regulated in non-apCR tissues. No 34938660 AC009237.14 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Regulation Bioinformatics Analysis Combined with the overall survival data, we established 6 six lncRNA-based signature to predict prognosis, which were LINC00896, AC007996.1, NKILA, AP003555.2, MIRLET7BHG, and AC009237.14. We found that the expression level of PD-L1 (CD274) and somatic mutations in the high-risk group were higher than those in the low-risk group. No 34790382 AC008753.6 LncRNA Homo sapiens Leukemia, Myeloid, Acute Bone marrow Expression[lower expressed] qPCR//RNA-seq In further qPCR validation, lncRNA RP11-342M1.7 and lncRNA CDCA4P3 were upregulated, while lncRNA CES1P1, lncRNA AC008753.6 and lncRNA RP11-573G6.13 were downregulated in AML patients compared with controls. No 31356197 AC008592.4-201 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC007996.1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues Regulation Bioinformatics Analysis Combined with the overall survival data, we established 6 six lncRNA-based signature to predict prognosis, which were LINC00896, AC007996.1, NKILA, AP003555.2, MIRLET7BHG, and AC009237.14. We found that the expression level of PD-L1 (CD274) and somatic mutations in the high-risk group were higher than those in the low-risk group. No 34790382 AC007950.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [highly expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 AC007728.3 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[highly expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 AC007682.1 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 AC007255.8 LncRNA Homo sapiens Lung Neoplasms 2B-NNK cells and lung cancer tissues Epigenetics(hypermethylation) Western Blot//CCK8//qRT-PCR//Cell Apoptosis Assay//Microarray QRT-PCR revealed that the expression of lncRNA AC007255.8 was remarkably downregulated in 2B-NNK cells and lung cancer tissues. The reduced expression of lncRNA AC007255.8 was significantly associated with hypermethylation of lncRNA AC007255.8 promoter region. In conclusion, NNK induced lncRNA AC007255.8 promoter hypermethylation via upregulation of DNMT1 in Beas-2B cells, leading to downregulation of lncRNA AC007255.8, and ultimately the enhancement of cell proliferation and the inhibition of apoptosis. No 33872747 AC007255.1 LncRNA Homo sapiens Esophageal Neoplasms ESCA tissues Expression(highly expressed) qRT-PCR AC007255.1 was a key eRNA. PRR15 was a target gene of AC007255.1 (correlation coefficient r = 0.936). Patients with high AC007255.1 expression indicated poor OS time. qRT-PCR results confirmed that AC007255.1 and PRR15 were both up-regulated in ESCA tissues, and there was a positive correlation between the two. AC007255.1 was a key eRNA. PRR15 was a target gene of AC007255.1 (correlation coefficient r = 0.936). Patients with high AC007255.1 expression indicated poor OS time.There were significant correlations between AC007255.1 expression and clinical characteristics like pathological TNM, grade and stage. No 34316393 AC007128.1 LncRNA Homo sapiens Tuberculosis TB patients Expression(highly expressed) Genotyping We identified two differentially expressed lncRNA including AC007128.1 and AP001065.3 in comparisons of expression profiles between ATB vs. LTBI, LTBI vs. HCs, and AC007128.1 expression was specifically and significantly up-regulated in TB patients by verification of external data. No 34277818 AC007099.1 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC CELLS Interaction(miR-7152/FAP ) qRT-PCR The lncRNA AC007099.1, which may serve as a potential target for the treatment of hepatocellular carcinoma, was associated with liver cancer. AC007099.1/miR-7152/FAP was found to be associated with immune infiltration in patients with hepatocellular carcinoma. No 35186170 AC007036.3 LncRNA Homo sapiens Breast Neoplasms Luminal-B breast cancer tissue Expression[lower expressed] RNA-seq A total of 1178 DEmRNAs (666 up-regulated and 512 down-regulated DEmRNAs) and 273 DElncRNAs (181 up-regulated and 92 down-regulated DElncRNAs) were obtained. The top 10 up- and down-regulated DEmRNAs and DElncRNAs were exhibited in Table 2 and Table 3, respectively. No 31795964 AC006504.5-226 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 AC006022.4 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)83) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 AC005699.1-228 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 2610035D17Rik-202 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[lower expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 12. No 30974198 hsa_circ_104804 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 28 downregulated differentially expressed circRNAs (Table III). No 29928369 circPDSS1 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Interaction[sponging miR-186-5p and modulating NEK2] qRT-PCR Our results showed that circPDSS1 and NEK2 were high-expressed whereas miR-186-5p was low-expressed in GC tissues and cells. CircPDSS1 promoted GC cell cycle and inhibited apoptosis by sponging miR-186-5p, while miR-186-5p inhibited cell cycle and promoted apoptosis by targeting NEK2. Thus, circPDSS1 acts as a tumor promoter by regulating miR-186-5p and NEK2, which could be a potential biomarker and therapeutic target for the management of GC. No 30417526 hsa_circ_103477 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104984 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104968 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_101585 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_102540 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_103568 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100144 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_105041 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_103901 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100061 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104046 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104351 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104601 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_102489 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_102471 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104280 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_101657 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104318 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_102212 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100752 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104190 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_001369 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100677 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_0023642 CircRNA Homo sapiens Stomach Neoplasms GC tissues and cell lines Regulation[EMT] Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay We found that circRNA_0023642 was upregulated in GC tissues and cell lines.Mechanically, our results revealed that the abnormal expression of circRNA_0023642 could influence the EMT signaling pathway, which was demonstrated by measuring the expression levels of N-cadherin, vimentin snail, and E-cadherin. Functionally, down-regulation of circRNA_0023642 displayed the tumor-inhibitory effects by suppressing cell proliferation, migration, and invasion as well as inducing apoptosis. No 29762831 hsa_circ_0020050 CircRNA Homo sapiens Stomach Neoplasms cancer tissues Expression[highly expressed] qRT-PCR Three circRNAs, hsa_circ_0020050, hsa_circ_0004030, and hsa_circ_0123778 (circ-CTNNB1), were upregulated in the tissues of gastric cancer, prostate cancer, and colorectal cancer No 30563889 circDCAF6 CircRNA Homo sapiens Stomach Neoplasms GC tissues,cells lines( AGS, BGC823, MGC803, and SGC7901) Interaction[miR-1231 and miR-1256] qRT-PCR//Luciferase Report Assay//Transwell Assay Expression[Expression[up-expression]-expression]regulation of circ-DCAF6 was determined in GC tissue samples and cells by qRT-PCR. Mechanistically, we found the negative correlation between circ-DCAF6 and miR-1231/-1256 in GC specimens. Moreover, luciferase reporter gene assay illustrated that miR-1231 and miR-1256 could be bound to circ-DCAF6. Rescue experiments revealed that circ-DCAF6 facilitated cell growth and invasion via sExpression[Expression[up-expression]-expression]pressing the levels of miR-1231 and miR-1256. Enhanced level of circ-DCAF6 was linked to deeper tumor invasion, positive lymph node metastasis, and higher TNM stages in GC patients. No 31226266 hsa_circ_0103398 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//Microarray Real-time PCR experiments on hsa_circ_0103398 and hsa_circ_0127859 in tumors and normal tissues showed that these circRNAs were significantly Expression[Expression[up-expression]-expression]regulated in GC. High expression of hsa_circ_0103398 and hsa_circ_0127859 was closely associated with unfavorable survival time. No 31672718 hsa_circ_0127859 CircRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[Expression[Expression[highly expressed]-expression]-expression] qRT-PCR//Microarray Real-time PCR experiments on hsa_circ_0103398 and hsa_circ_0127859 in tumors and normal tissues showed that these circRNAs were significantly Expression[Expression[up-expression]-expression]regulated in GC. High expression of hsa_circ_0103398 and hsa_circ_0127859 was closely associated with unfavorable survival time. No 31672718 circNOTCH1 CircRNA Homo sapiens Stomach Neoplasms GC tissues,cell lines Interaction[sponging miR-637] qRT-PCR//Luciferase Report Assay//Western Blot Circ-NOTCH1 and Apelin are highly expressed in GC cells and tissues, whereas the expression of miR-637 is reduced. Circ-NOTCH1 and miR-637 do not regulate each other's expression levels, but circ-NOTCH1significantly Expression[Expression[up-expression]-expression]regulates the expression of the miR-637 target gene Apelin, whereas miR-637 inhibites the expression of Apelin. No 31276627 hsa_circ_0065149 CircRNA Homo sapiens Stomach Neoplasms Gastric Cancer tissues Expression[lower expressed] qRT-PCR//Microarray Hsa_circ_0065149 expression was only significantly down-regulated in gastric cancer, not changed among healthy gastric mucosa and gastritis intestinal metaplasia. Low hsa_circ_0065149 expression levels in GC tissues were significantly associated with tumor diameter (P = 0.034) and perineural invasion (P = 0.037). GC patients with low hsa_circ_0065149 levels had a much longer overall survival than those in high group (P = 0.020). More important, hsa_circ_0065149 levels were significantly decreased in plasma exosomes of early GC patients. As a screening biomarker for early GC, hsa_circ_0065149 in plasma exosomes has higher sensitivity and specificity than traditional clinical biomarkers. Bioinformatics analysis suggest that the abnormal expression of hsa_circ_0065149 may play an important role during gastric carcinogenesis. No 31432324 hsa_circ_100801 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100109 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_102678 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 29 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_102464 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100261 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 30 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100927 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 31 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100924 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 32 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100922 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 33 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_102713 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 34 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_102499 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 35 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_102315 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 36 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100911 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 37 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104850 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 38 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100925 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 39 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_102293 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 40 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_102737 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 41 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104868 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 42 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100381 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 43 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104707 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 44 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104532 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 45 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104492 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 46 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104689 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 47 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100380 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 48 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104016 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 49 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100715 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 50 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_101270 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 51 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_102830 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 52 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100241 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 53 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_104052 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 54 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_102298 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 55 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_100097 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[highly expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_103538 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 hsa_circ_102016 CircRNA Homo sapiens Stomach Neoplasms gastric tissues Expression[lower expressed] qRT-PCR//Microarray We set a threshold as log2 fold-change >5 in upregulated circRNAs, >3 in downregulated circRNAs as the previous study (17), and P-value <0.05, and found 29 upregulated (Table II) and 56 downregulated differentially expressed circRNAs (Table III). No 29928369 ATG9B LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ATOSA LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 ATP5F1C-207 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 chr1_77641655_77631835_-9820 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 306 were up-regulated and down-regulated, respectively. No 31843366 chr1_66963160_66958059_-5101 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 345 were up-regulated and down-regulated, respectively. No 31843366 chr1_61359274_61277520_-81754 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 355 were up-regulated and down-regulated, respectively. No 31843366 chr1_53832591_53800693_-31898 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 480 were up-regulated and down-regulated, respectively. No 31843366 chr1_52796784_52756458_-40326 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 512 were up-regulated and down-regulated, respectively. No 31843366 chr1_52509712_52493611_-16101 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 251 were up-regulated and down-regulated, respectively. No 31843366 chr1_51406108_51403419_-2689 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 382 were up-regulated and down-regulated, respectively. No 31843366 chr1_42775479_42773563_-1916 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 364 were up-regulated and down-regulated, respectively. No 31843366 chr1_41009589_41008794_-795 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 343 were up-regulated and down-regulated, respectively. No 31843366 chr1_30981405_30964674_-16731 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 269 were up-regulated and down-regulated, respectively. No 31843366 chr1_237667958_237657944_-10014 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 459 were up-regulated and down-regulated, respectively. No 31843366 chr1_237667958_237648523_-19435 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 241 were up-regulated and down-regulated, respectively. No 31843366 chr1_237469187_237387156_-82031 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 397 were up-regulated and down-regulated, respectively. No 31843366 chr1_237388183_237374717_-13466 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 319 were up-regulated and down-regulated, respectively. No 31843366 chr1_234472811_234418084_-54727 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 472 were up-regulated and down-regulated, respectively. No 31843366 chr1_228304566_228303675_-891 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 240 were up-regulated and down-regulated, respectively. No 31843366 chr1_228294415_228293353_-1062 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 238 were up-regulated and down-regulated, respectively. No 31843366 chr1_228264391_228243183_-21208 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 239 were up-regulated and down-regulated, respectively. No 31843366 chr1_225023865_224952670_-71195 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 451 were up-regulated and down-regulated, respectively. No 31843366 chr1_21757783_21747067_-10716 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 295 were up-regulated and down-regulated, respectively. No 31843366 chr1_198264235_198253040_-11195 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 444 were up-regulated and down-regulated, respectively. No 31843366 chr1_197715074_197583152_-131922 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 410 were up-regulated and down-regulated, respectively. No 31843366 chr1_197357013_197328422_-28591 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 417 were up-regulated and down-regulated, respectively. No 31843366 chr1_15721390_15717891_-3499 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 431 were up-regulated and down-regulated, respectively. No 31843366 chr1_155726019_155721517_-4502 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 436 were up-regulated and down-regulated, respectively. No 31843366 chr1_155482449_155459797_-22652 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 443 were up-regulated and down-regulated, respectively. No 31843366 chr1_150941428_150929967_-11461 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 332 were up-regulated and down-regulated, respectively. No 31843366 chr1_117502970_117460489_-42481 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 479 were up-regulated and down-regulated, respectively. No 31843366 chr1_117420649_117402186_-18463 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 248 were up-regulated and down-regulated, respectively. No 31843366 chr1_114738072_114719579_-18493 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 321 were up-regulated and down-regulated, respectively. No 31843366 chr1_70152543_70145709_-6834 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 350 were up-regulated and down-regulated, respectively. No 31843366 chr10_100944128_100937402_-6726 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 412 were up-regulated and down-regulated, respectively. No 31843366 CHMP4BP1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 946 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 chr10_12084751_12081472_-3279 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 487 were up-regulated and down-regulated, respectively. No 31843366 chr12_80367739_80355736_-12003 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 497 were up-regulated and down-regulated, respectively. No 31843366 chr12_80279166_80229257_-49909 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 430 were up-regulated and down-regulated, respectively. No 31843366 chr12_66217235_66203711_-13524 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 425 were up-regulated and down-regulated, respectively. No 31843366 chr12_62538505_62537151_-1354 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 277 were up-regulated and down-regulated, respectively. No 31843366 chr12_55701154_55700899_-255 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 483 were up-regulated and down-regulated, respectively. No 31843366 chr12_50461347_50454314_-7033 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 504 were up-regulated and down-regulated, respectively. No 31843366 chr12_45839496_45836589_-2907 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 491 were up-regulated and down-regulated, respectively. No 31843366 chr12_2612013_2549943_-62070 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 455 were up-regulated and down-regulated, respectively. No 31843366 chr12_20646950_20621296_-25654 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 358 were up-regulated and down-regulated, respectively. No 31843366 chr12_124495368_124457106_-38262 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 302 were up-regulated and down-regulated, respectively. No 31843366 chr12_124457162_124419957_-37205 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 326 were up-regulated and down-regulated, respectively. No 31843366 chr12_110323072_110296599_-26473 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 235 were up-regulated and down-regulated, respectively. No 31843366 chr11_34978182_34957384_-20798 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 311 were up-regulated and down-regulated, respectively. No 31843366 chr11_19351027_19350373_-654 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 407 were up-regulated and down-regulated, respectively. No 31843366 chr11_17145942_17131916_-14026 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 341 were up-regulated and down-regulated, respectively. No 31843366 chr11_14861366_14830698_-30668 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 421 were up-regulated and down-regulated, respectively. No 31843366 chr11_130261929_130260856_-1073 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 260 were up-regulated and down-regulated, respectively. No 31843366 chr11_125614426_125612592_-1834 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 490 were up-regulated and down-regulated, respectively. No 31843366 chr11_121060085_121036505_-23580 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 392 were up-regulated and down-regulated, respectively. No 31843366 chr11_118494767_118489792_-4975 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 309 were up-regulated and down-regulated, respectively. No 31843366 chr11_104000255_103926912_-73343 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 457 were up-regulated and down-regulated, respectively. No 31843366 chr10_94522453_94474668_-47785 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 324 were up-regulated and down-regulated, respectively. No 31843366 chr10_86726252_86687069_-39183 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 272 were up-regulated and down-regulated, respectively. No 31843366 chr10_73074915_73030271_-44644 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 368 were up-regulated and down-regulated, respectively. No 31843366 chr10_69401275_69384796_-16479 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 377 were up-regulated and down-regulated, respectively. No 31843366 chr10_63209235_63206595_-2640 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 334 were up-regulated and down-regulated, respectively. No 31843366 chr10_34360259_34269657_-90602 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 346 were up-regulated and down-regulated, respectively. No 31843366 chr10_20868765_20859713_-9052 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 283 were up-regulated and down-regulated, respectively. No 31843366 chr10_20840849_20840739_-110 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 256 were up-regulated and down-regulated, respectively. No 31843366 chr1_112616895_112591525_-25370 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 348 were up-regulated and down-regulated, respectively. No 31843366 CHL1-AS2 LncRNA Homo sapiens Breast Neoplasms serum of BC patients and healthy subjects Expression [highly expressed] RNA-seq After a comprehensive comparison of the BC patients and healthy subjects, we discovered five up-regulated exo-lncRNAs and six down-regulated exo-lncRNAs of interest. No 34733934 chr12_80635073_80588129_-46944 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 460 were up-regulated and down-regulated, respectively. No 31843366 CDR1as CircRNA Homo sapiens Osteonecrosis blood Expression[highly expressed] qRT-PCR Plasma Circ CDR1as expressions were significantly higher in non-traumatic ONFH patients compared with healthy controls. No 33298118 CDKN2B‐AS1 LncRNA Homo sapiens Colonic Neoplasms COAD tissues Expression[lower expressed] qRT-PCR "To manifest the expression of integrated analysis, we selected the previously obtained eight biomarkers including XXbac‐ B476C20.9, PP7080, CDKN2B‐AS1, LINC00092, CA3‐AS1, HAND2‐AS1, CTD‐2269F5.1, and LINC01082. In Figure 8, these eight selected DElncRNAs for qRT‐PCR confirmation were eight optimal diagnostic lncRNA biomarkers, and these eight DElncRNAs were all downregulated in the high‐ throughput transcriptome datasets for COAD compared with normal controls. The expression of these selected eight genes in qRT‐PCR was consistent with our integrated analysis." No 30269368 CDKN2B-AS1 LncRNA Homo sapiens Breast Neoplasms breast tumor and adjacent tissue Expression[highly expressed] qRT-PCR//MTT In breast tumors ANRIL was increased in RNA extracted from tumor tissue compared to the patient-matched normal tissue adjacent to the tumor ANRIL No 31572679 CDKN2B-AS1 LncRNA Homo sapiens Breast Neoplasms serum Mutation(rs2383207 ) qRT-PCR CDKN2B-AS1 serum levels were upregulated in the BC patients relative to controls. A/A genotype carriers were three times more likely to develop BC under homozygous (OR = 3.27, 95% CI 1.20-8.88, P = 0.044) and recessive (OR = 3.17, 95% CI 1.20-8.34, P = 0.013) models. G/G homozygous patients had a higher expression level [median and quartile values were 3.14 (1.52-4.25)] than A/G [1.42 (0.93-2.35)] and A/A [1.62 (1.33-2.51)] cohorts (P = 0.006). The Kaplan-Meier curve also revealed a higher mean survival duration of G/G cohorts (20.6 months) compared to their counterparts (A/A: 15.8 and A/G: 17.2 months) (P < 0.001). Consistently, BC data sets revealed better survival in cohorts with high expression levels (P = 0.003). Principal component analysis (PCA) showed a deviation of patients who had shorter survival towards A/A and A/G genotypes, multiple lesions, advanced stage, lymphovascular invasion, and HER2+ receptor staining. Ingenuity Pathway Analysis (IPA) showed key genes highly enriched in BC with CDKN2B-AS1. No 33849428 CDKN2B-AS1 LncRNA Homo sapiens Breast Neoplasms 504 Chinese Han patients and 505 controls Mutation(rs10965215 ) qRT-PCR//Luciferase Report Assay The relative expression of CDKN2B-AS1 in rs10965215 homozygous wild AA genotype (8.88 ± 3.43) was lower than heterozygous GA (11.08 ± 2.90) and homozygous mutant GG genotype (11.31 ± 2.90). When rs10965215 wild A genotype was carried, there was an interaction between CDKN2B-AS1 and miR-4440. No 34954153 CDKN2B-AS1 LncRNA Homo sapiens Breast Neoplasms serum Expression(highly expressed) qRT-PCR Increased ANRIL (3.83-fold), TUG1 (7.64-fold), UCA1 (7.82-fold), and HIT (3.31-fold) expressions were observed in breast cancer patients compared to healthy controls. While lncRNA TUG-1 expression was found to be higher in patients with early-stage tumors than those with advanced-stage tumors (p = 0.06), lncRNA ANRIL showed increased expression in patients with PR positive status (p = 0.04). However, we found a significant difference in lncRNA HIT expression in HER-2 positive breast cancer patients compared to HER-2 negative breast cancer patients (p = 0.005). An increase in the expression of serum lncRNAs ANRIL (p < 0.0001), UCA-1 (p = 0.004), and HIT (p < 0.0001) was observed in the distant organ metastatic breast cancer patients. No 35132340 CDKN2B-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC tissues Expression[highly expressed] qRT-PCR ESCC tissues examined showed an obvious increment in ANRIL expression when compared to normal tissues. Disease-free survival (DFS) and overall survival (OS) were significantly shorter in ESCC patients with higher expression level of lncRNA ANRIL. Furthermore, ANRIL was positively related to lymph nodes metastasis, TNM stage and tumor clinical stage. Moreover, upregulated ANRIL expression was remarkably associated with shorter survival in ESCC patients,which was also an independent prognostic factor for both OS and DFS. No 30610814 CDKN2B-AS1 LncRNA Homo sapiens Endometrial Neoplasms EC tissues and cell lines Expression[highly expressed] qRT-PCR Firstly, CDKN2B-AS gene was highly expressed in EC tissues and cell lines. No 30761271 CDKN2B-AS1 LncRNA Homo sapiens Neoplasms cancer tissues Expression[highly expressed] qRT-PCR We observed the overexpression of the four genes ANRIL, p16-CDKN2A, p15-CDKN2B, and p14-ARF in the great majority of the 17 different cancer types. ANRIL was upregulated in 13/17 tumors compared to normal tissues, ranging from 5% (prostate cancer) to 91% (cervix cancer), with variable expression of p16-CDKN2A, p15-CDKN2B, and p14-ARF genes. A high positive correlation was identified between levels of expression of ANRIL and the three tumor suppressors. The strongest positive association was observed with p14-ARF (p < 0.001) in all but one (lung squamous cell carcinoma) of the examined tumor types. No 30415008 CDKN2B-AS1 LncRNA Homo sapiens Parkinson Disease Seventy-eight PD patients and 78 age-/gender-matched controls were consecutively enrolled. Interaction(miR-34a and miR-125a) qRT-PCR LncRNA ANRIL was upregulated, while miR-34a and miR-125a were downregulated in PD patients compared to controls (all p < 0.001). Furthermore, lncRNA ANRIL negatively correlated with miR-34a (p = 0.016) and miR-125a (p = 0.005) in PD patients, but not in controls. In addition, lncRNA ANRIL was observed to positively associate with UPDRS-I score (p = 0.029), UPDRS-III score (p = 0.006), and UPDRS-IV score (p = 0.033), while negatively correlated with MMSE score (p = 0.003). No 34921567 CDKN2B-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute Bone marrow mononuclear cells Expression[highly expressed] qRT-PCR The levels of lncRNA ANRIL were increased in patients with AML compared with those in healthy donors and were capable of distinguishing patients with AML from healthy donors (area under the curve, 0.886; 95% CI, 0.820?0.952). Furthermore, lncRNA ANRIL was significantly associated with a lower CR rate. In addition, EFS and OS were shorter in patients with high expression of lncRNA ANRIL compared with those in patients with low expression of lncRNA ANRIL. Multivariate Cox regression analyses revealed that high expression of lncRNA ANRIL, poor?risk stratification and white blood cells (>10.0x109 cells/l) were independent prognostic factors for shorter EFS, while high expression of lncRNA ANRIL and poorer risk stratification were independent prognostic factors for shorter OS. No 33300059 CDKN2B-AS1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML bone marrow samples Expression(highly expressed) PCR Both lnRNA SNHG14 and lnRNA ANRIL showed high expression levels in AML bone marrow samples compared to non-AML subjects and were remarkably associated with lower Complete Remission (OR: 3.449, 95% CI: 1.324-8.985, p=0.011 for ANRIL and OR: 3.955, 95% CI: 1.510-10.356, p=0.005 for SNHG14), Relapse Free Survival (HR=3.504, 95%CI: 1.662-7.387, p=0.001 for ANRIL and HR=4.094, 95%CI: 1.849-9.067, p=0.001 for SNHG14) and Overall Survival (HR=3.353, 95%CI: 1.434-7.839, p=0.005 for ANRIL and HR=3.094, 95%CI: 1.277-7.494, p=0.012 for SNHG14), favouring poor prognostic significance in AML. Both lnRNA SNHG14 and lnRNA ANRIL showed high expression levels in AML bone marrow samples compared to non-AML subjects and were remarkably associated with lower Complete Remission (OR: 3.449, 95% CI: 1.324-8.985, p=0.011 for ANRIL and OR: 3.955, 95% CI: 1.510-10.356, p=0.005 for SNHG14), Relapse Free Survival (HR=3.504, 95%CI: 1.662-7.387, p=0.001 for ANRIL and HR=4.094, 95%CI: 1.849-9.067, p=0.001 for SNHG14) and Overall Survival (HR=3.353, 95%CI: 1.434-7.839, p=0.005 for ANRIL and HR=3.094, 95%CI: 1.277-7.494, p=0.012 for SNHG14), favouring poor prognostic significance in AML. No 34967554 CDKN2B-AS1 LncRNA Homo sapiens Glioma Mutation[rs2151280 ] Genotyping ANRIL rs2151280 variant genotype might increase susceptibility of glioma. No 31489712 CDKN2B-AS1 LncRNA Homo sapiens Thyroid Neoplasms TC samples Expression(highly expressed) Bioinformatics Analysis Combining RNA-seq and survival data, we identified that CDKN2B-AS1 was upregulated in TC samples and could be an excellent prognostic indicator. Meanwhile, ssGSEA and ESTIMATE algorithms revealed that CDKN2B-AS1 overexpression may suggest the active state of the immune microenvironment. No 35432631 CDKN2B-AS1 LncRNA Homo sapiens Thyroid Cancer, Papillary papillary thyroid cancer Mutation(rs10757274, rs1333040, rs1333048, rs4977574 ) PCR Certain haplotypes of ANRIL SNPs are associated with papillary thyroid cancer. ANRIL rs1333048 and rs4977574 variants were associated with larger and smaller tumour sizes, respectively. rs10757274 and rs1333040 variants might lead to lower III-IV cancer stages. Certain haplotypes of ANRIL SNPs are associated with papillary thyroid cancer. ANRIL rs1333048 and rs4977574 variants were associated with larger and smaller tumour sizes, respectively. rs10757274 and rs1333040 variants might lead to lower III-IV cancer stages. No 33186076 CDKN2B-AS1 LncRNA Homo sapiens Multiple Myeloma 87 MM patients and 30 controls Expression [highly expressed] qRT-PCR LncRNA ANRIL expression was increased, while miR-34a, miR-125a and miR-186 expressions were reduced in MM patients compared with controls. In MM patients, lncRNA ANRIL high expression associated with higher beta-2-microglobulin (β2-MG) and more advanced international staging system (ISS) stage; miR-125a high expression associated with lower β2-MG, less advanced ISS stage and less t (14; 16) abnormality; miR186 high expression associated with increased albumin; while miR-34a did not associate with any clinical features. No 33528317 CDKN2B-AS1 LncRNA Homo sapiens Pancreatic Neoplasms Mutation[rs1537373 ] Genotyping The strongest signal was rs6475609 (Odds ratio, OR = 0.81, 95% confidence interval, CI = 0.72-0.91) maps to the long non-coding RNA ANRIL. Bioinformatics analysis revealed rs1537373 lies in the linkage disequilibrium (LD) block which the rs6475609 tagged might have potential function and was also associated with a decreased risk of PC in both stages (OR = 0.82, 95% CI = 0.75-0.90 in combined analysis). Dual luciferase reporter assay and the electrophoretic mobility shift assay (EMSA) verified rs1537373 as the best candidate causative variant for influencing the activity of enhancer through differential binding to certain transcription factor. The expression quantitative trait loci (e-QTL) analysis indicated the genotypes of rs1537373 were associated with expression of CDKN2B gene (P dominant = 6.00 × 10-4 ). In conclusion, our study provided evidence that rs1537373 in ANRIL may influence transcription factor binding and regulate CDKN2B expression, thus confer the susceptibility to PC. No 30604909 CDKN2B-AS1 LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 CDKN2B-AS1 LncRNA Homo sapiens Liver Neoplasms liver cancer tissues Expression[highly expressed] CCK8//qRT-PCR The expression of CDKN2B-AS1 in liver cancer was significantly higher compared to normal tissues. The data of CDKN2B-AS1 showed that the expression of CDKN2B-AS1 was associated with the total survival, tumor size and TNM staging. No 31646789 CDKN2B-AS1 LncRNA Homo sapiens Coronary Artery Disease blood Expression[highly expressed] ELISA The relative expression of ANRIL was higher in CAD patients compared to controls (P<0.001). Receiver operating characteristic disclosed that ANRIL could distinguish CAD patients from controls with an area under the curve of 0.789 (95%CI: 0.731-0.847). Spearman's rank correlation test revealed that expression of ANRIL was positively correlated with Gensini score (P=0.001), levels of hs-CRP (P=0.001), ESR (P=0.038), TNF-α (P=0.004), and IL-6 (P<0.001), while negatively correlated with IL-10 level (P=0.008) in CAD patients. Kaplan-Meier curve revealed that high expression of ANRIL was associated with shorter OS (P=0.013). In conclusion, circulating ANRIL presented a good diagnostic value for CAD, and its high expression was associated with increased stenosis degree, raised inflammation, and poor OS in CAD patients. No 31411246 CDKN2B-AS1 LncRNA Homo sapiens Coronary Artery Disease blood Expression[lower expressed] qRT-PCR ANRIL, IL-1B and NKILA were significantly down-regulated in CAD patients compared with controls (p values of <.0001, .023 and <.0001, respectively). No 31913058 CDKN2B-AS1 LncRNA Homo sapiens Coronary Artery Disease 25 subjects with CAD Expression(lower expressed) IP Circular ANRIL was significantly lower in the case group while linear counterparts were significantly higher in this group. Circular/linear ratio was also significantly lower in the case group. To overcome growing devastating trend of CAD, scrutinizing different factors involved in the initiation and development of atherosclerosis is a must. Atheroprotective role of circular ANRIL and atheroprogressive role of linear ANRIL were shown in our patients with hypertension. No 35110626 CDKN2B-AS1 LncRNA Homo sapiens Rhinitis, Allergic nasal mucosa tissue Expression[highly expressed] qRT-PCR LncRNA ANRIL expression was increased in AR patients (3.605 [1.763-4.981]) compared with controls (1.183 [0.438-2.985]), No 31096432 CDKN2B-AS1 LncRNA Homo sapiens Ischemic Stroke blood Expression[lower expressed] qRT-PCR Plasma lncRNA ANRIL expression was lower in AIS patients than in controls (P < 0.001), and the receiver operating characteristic (ROC) curve showed a good prediction value of lncRNA ANRIL for AIS risk with area under curve (AUC) of 0.759 (95% CI: 0.741-0.849). No 30069916 CDKN2B-AS1 LncRNA Homo sapiens Crohn Disease Inflamed intestinal mucosa Expression[lower expressed] qRT-PCR LncRNA ANRIL expression was decreased in patients with A-CD compared with patients with R-CD (P < 0.001) and controls (P < 0.001) and was also reduced in patients with R-CD compared with controls (P < 0.001). No 30665494 CDKN2B-AS1 LncRNA Homo sapiens Colitis, Ulcerative colonic biopsy tissue Expression[lower expressed] qRT-PCR//Western Blot One of the most significantly decreased genes on the array was CDKN2B-AS1 with a 12.2-fold Expression[down-expression]regulation and p = 0.00087 (Fig. 1a). This result is similar to that reported by others that have shown that CDKN2B-AS1 is significantly Expression[down-expression]-regulated in both ulcerative colitis and Crohn’s disease patients [7,12,13]. No 31207308 CDKN2B-AS1 LncRNA Homo sapiens Abortion, Habitual Southern Chinese Population Mutation(rs2151280 ) Genotyping Our results showed that the ANRIL rs2151280 GG genotype was associated with increased susceptibility to recurrent miscarriage (GG vs AA: adjusted OR=1.527, 95% CI=1.051-2.218, p=0.0262; GG vs AG/AA adjusted OR=1.460, 95% CI=1.021-2.089, p=0.0381). No 34234511 CDKN2B-AS1 LncRNA Homo sapiens Glaucoma blood Expression[lower expressed] qRT-PCR Compared with those in the control group, patients in the study group had significantly lower expression of serum lncRNA MALAT1 and lncRNA ANRIL (P<0.05), significantly lower expression of serum PEDF and IL-12 (P<0.05), and significantly higher expression of serum Hcy and IL-4 (P<0.05), without significant difference in the expression of serum IFN-γ between the two groups (P>0.05). No 32010306 CDKN2B-AS1-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CDR1as CircRNA Homo sapiens bladder urothelial carcinoma bladder urothelial carcinoma tissues Expression[highly expressed] qRT-PCR In the current study, we showed novel data that the expression of CDR1as in bladder urothelial carcinoma tissues was significantly higher than that in adjacent tissues. In patients with lymph node metastasis, the expres-sion of CDR1as was also significantly higher. Moreover, the expression of CDR1as was higher in high-stage, high-grade bladder urothelial carcinoma than in low-stage and low-grade cancer tissues. No 32658427 CHL1-AS2 LncRNA Homo sapiens endometriosis of ovary EC tissues Expression[highly expressed] qPCR//IHC//Western Blot qPCR confirmed that the CHL1 and CHL1-AS2 expression levels were significantly higher in EC tissues than in EU and NE tissues, while they were not significantly different in EU compared with NE tissues. No 30943448 CDR1as CircRNA Homo sapiens Heart Failure plasma regulation[miR-135a/HMOX1 and miR-135b/HMOX1 Axes] ELISA//qPCR//PCR CDR1as was upregulated in the plasma of patients with CHF and is a potential diagnostic marker of CHF. CDR1as is a potential biomarker of CHF that is mechanistically involved in the disease pathogenesis and participates in regulating the occurrence and development of CHF through the miR-135a/HMOX1 and miR-135b/HMOX1 signaling axes. No 32762552 CHL1 LncRNA Homo sapiens Adrenocortical Carcinoma ACC tissues Expression[highly expressed] qRT-PCR//Microarray In these samples, 874 lncRNAs were differentially expressed in ACC compared with NAC, of which 409 were upregulated, and 465 were downregulated. The 874 differentially expressed lncRNAs corresponded to 330 annotated lncRNA genes. Among the upregulated lncRNAs, the greatest log2 fold change was 8.5 for an unannotated lncRNA gene, and RAD50 was the geratest upregulated, annotated lncRNA gene with a log2 fold change of 6.1. Among the downregulated lncRNAs, the greatest log2 fold change was 8.3 for an unannotated lncRNA gene and 6.4 for HAND2, the greatest downregulated annotated lncRNA gene; of these, 183 differently expressed lncRNAs had established functions in cancer development and cancer progression. Selected carcinogenesis-related lncRNAs are summarized in Table 2. No 31522749 CHEK1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 CHCHD2P6 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)45) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 CHCHD10 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 CHARR LncRNA Mus musculus Cardiomegaly Heart tissue Interaction[PTEN/AKT pathway] PCR//Western Blot CHAR down-regulation alone was sufficient to induce hypertrophic phenotypes in healthy mice and neonatal rat ventricular cells (NRVCs). Overexpression of CHAR reduced the hypertrophic responses. CHAR was found to act as a competitive endogenous RNA (ceRNA) to down-regulate miR-20b that we established as a pro-hypertrophic miRNA. We experimentally established phosphatase and tensin homolog (PTEN), an anti-hypertrophic signalling molecule, as a target gene for miR-20b. We found that miR-20b induced CH by directly repressing PTEN expression and indirectly increasing AKT activity. Moreover, CHAR overexpression mitigated the repression of PTEN and activation of AKT by miR-20b, and as such, it abrogated the deleterious effects of miR-20b on CH. Collectively, this study characterized a new lncRNA CHAR and unravelled a new pro-hypertrophic signalling pathway: lncRNA-CHAR/miR-20b/PTEN/AKT. The findings therefore should improve our understanding of the cellular functionality and pathophysiological role of lncRNAs in the heart. No 31465630 CFL1P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CFAP46-208 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CFAP20 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CF129 LncRNA Homo sapiens Pancreatic Neoplasms PC tissues Interaction[p53] RNA Pull-Down//IP CF129 levels were markedly lower in PC compared with paired non-tumor adjacent tissues. In addition, CF129 regulates FOXC2 transcription through association with mutant p53. CF129 directly binds to p53 and E3 ligase MKRN1, and such an interaction leading to p53 protein ubiquitination and degradation. Furthermore, CF129 is a hypoxia-responsive lncRNA, which is transcriptionally downregulated by binding between HIF-1α/HDAC1 complex and CF129 promoter. Finally, it is revealed that HIF-1α is reciprocally regulated by FOXC2 in transcriptional level. Clinically, CF129 downregulation coordinates overexpression of FOXC2. Low CF129 expression predicted short overall survival in PC patients. No 31367258 CES2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CES1P1 LncRNA Homo sapiens Leukemia, Myeloid, Acute Bone marrow Expression[lower expressed] qPCR//RNA-seq In further qPCR validation, lncRNA RP11-342M1.7 and lncRNA CDCA4P3 were upregulated, while lncRNA CES1P1, lncRNA AC008753.6 and lncRNA RP11-573G6.12 were downregulated in AML patients compared with controls. No 31356197 CERS2-202 LncRNA Homo sapiens Coronary Artery Disease epicardial adipose tissue Expression[lower expressed] qRT-PCR Using a 2-fold expression difference as a cutoff, a total of 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) (Figure 2, Table 3) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (Figure 2). No 31355260 CERNA2 LncRNA Homo sapiens Stomach Neoplasms gastric cancer tissues Expression[highly expressed] Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Microarray//Transwell Assay "The results revealed that the HOST2 expression in the GC tumor tissues increased significantly compared to adjacent normal tissue (Figure 1B, **p<0.01). " No 30509094 CEP85 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 CEP41 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CENPW LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CENPU LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 CENPS LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CENPO LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CENPJ LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CENATAC LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CELF2-AS2 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CELF2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CECR7 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[lower expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 CEBPB-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CEBPA-DT LncRNA Homo sapiens Stomach Neoplasms GC cells Expression[highly expressed] qRT-PCR CEBPA-AS1 was highly expressed in both GC cells and in exosomes secreted by GC cells. No 32110038 CEBPA‐AS1 LncRNA Homo sapiens Adenocarcinoma of Lung Expression[highly expressed] qRT-PCR "The results showed that CEBPA‐AS1 and GVINP1 were downregulated in LUAD tumor tissues, while MIR31HG and RAET1K were upregulated in LUAD tumor tissues (Figure 4). The qRT‐PCR results of these four lncRNAs were consistent with our TCGA bioinformatics results, indicating that our TCGA analysis was credible" No 30125988 CDRT7 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CDR1as CircRNA Homo sapiens Nasopharyngeal carcinoma NPC tissues Interaction[miR-7-5p and E2F3 ] CCK8//qRT-PCR//Luciferase Report Assay//Western Blot The results showed that the circRNA CDR1as expression was significantly Expression[Expression[up-expression]-expression]-regulated in NPC tissues by comparison with non-tumor NPE tissues (p < 0.01), suggesting that circRNA CDR1as was associated with poor prognosis in NPC patients. Moreover, circRNA CDR1as could Expression[Expression[up-expression]-expression]-regulate E2F3 expression by binding miR-7-5p, and promote the growth and glucose metabolism of NPC cells. Meanwhile, circRNA CDR1as could promote NPC progression through the negative regulation of miR-7-5p in the xenograft tumor model. No 31582908 chr12_80510443_80443752_-66691 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 429 were up-regulated and down-regulated, respectively. No 31843366 chr12_80640619_80546556_-94063 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 312 were up-regulated and down-regulated, respectively. No 31843366 CDKN2B-AS1 LncRNA Homo sapiens Plaque, Atherosclerotic Atherosclerotic tissues Interaction[inhibiting ADAM10] RNA Pull-Down//Western Blot//FISH//qRT-PCR//RIP//Oil Red O Staining//ELISA//ChIP therosclerotic plaque tissue and THP-1 macrophage-derived foam cells exhibited downregulated CDKN2B-AS1 and upregulated ADAM10.CDKN2B-AS1 located in the nucleus could bind to DNA methyltransferase 1 (DNMT1) to enhance methylation of ADAM10 promoter, leading to suppressed atherosclerotic inflammatory response and promoted cholesterol efflux. No 30926762 chr20_35899648_35801491_-98157 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 511 were up-regulated and down-regulated, respectively. No 31843366 chr20_32371877_32366381_-5496 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 449 were up-regulated and down-regulated, respectively. No 31843366 chr2_85371562_85368686_-2876 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 502 were up-regulated and down-regulated, respectively. No 31843366 chr2_61493053_61482957_-10096 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 442 were up-regulated and down-regulated, respectively. No 31843366 chr2_55028220_55025086_-3134 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 423 were up-regulated and down-regulated, respectively. No 31843366 chr2_39299801_39265203_-34598 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 433 were up-regulated and down-regulated, respectively. No 31843366 chr2_36442735_36378357_-64378 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 264 were up-regulated and down-regulated, respectively. No 31843366 chr2_32401623_32377588_-24035 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 385 were up-regulated and down-regulated, respectively. No 31843366 chr2_32395593_32377588_-18005 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 337 were up-regulated and down-regulated, respectively. No 31843366 chr2_24584560_24564295_-20265 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 470 were up-regulated and down-regulated, respectively. No 31843366 chr2_217900512_217880898_-19614 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 501 were up-regulated and down-regulated, respectively. No 31843366 chr2_213375119_213310059_-65060 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 297 were up-regulated and down-regulated, respectively. No 31843366 chr2_196922186_196912882_-9304 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 452 were up-regulated and down-regulated, respectively. No 31843366 chr2_189696369_189689527_-6842 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 509 were up-regulated and down-regulated, respectively. No 31843366 chr2_182989186_182962159_-27027 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 340 were up-regulated and down-regulated, respectively. No 31843366 chr2_178727371_178719554_-7817 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 294 were up-regulated and down-regulated, respectively. No 31843366 chr2_178722134_178625273_-96861 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 245 were up-regulated and down-regulated, respectively. No 31843366 chr2_178721202_178693922_-27280 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 255 were up-regulated and down-regulated, respectively. No 31843366 chr2_178721202_178689813_-31389 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 274 were up-regulated and down-regulated, respectively. No 31843366 chr2_178721202_178681661_-39541 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 428 were up-regulated and down-regulated, respectively. No 31843366 chr2_178717382_178651453_-65929 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 243 were up-regulated and down-regulated, respectively. No 31843366 chr2_178715774_178685518_-30256 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 422 were up-regulated and down-regulated, respectively. No 31843366 chr2_178712031_178693922_-18109 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 263 were up-regulated and down-regulated, respectively. No 31843366 chr2_178689896_178650751_-39145 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 286 were up-regulated and down-regulated, respectively. No 31843366 chr2_178688224_178679599_-8625 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 281 were up-regulated and down-regulated, respectively. No 31843366 chr2_178688224_178678125_-10099 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 284 were up-regulated and down-regulated, respectively. No 31843366 chr2_178683291_178678125_-5166 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 244 were up-regulated and down-regulated, respectively. No 31843366 chr2_178682903_178673633_-9270 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 278 were up-regulated and down-regulated, respectively. No 31843366 chr2_178629443_178625273_-4170 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 242 were up-regulated and down-regulated, respectively. No 31843366 chr2_178601549_178601307_-242 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 320 were up-regulated and down-regulated, respectively. No 31843366 chr20_33629914_33619517_-10397 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 481 were up-regulated and down-regulated, respectively. No 31843366 chr20_37068186_37066724_-1462 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 391 were up-regulated and down-regulated, respectively. No 31843366 chr2_134362408_134336217_-26191 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 395 were up-regulated and down-regulated, respectively. No 31843366 chr20_47283648_47262288_-21360 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 271 were up-regulated and down-regulated, respectively. No 31843366 chr4_150491035_150415438_-75597 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 270 were up-regulated and down-regulated, respectively. No 31843366 chr4_147913139_147906638_-6501 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 323 were up-regulated and down-regulated, respectively. No 31843366 chr4_143543972_143543509_-463 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 453 were up-regulated and down-regulated, respectively. No 31843366 chr4_122207638_122192229_-15409 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 375 were up-regulated and down-regulated, respectively. No 31843366 chr4_113199109_113174416_-24693 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 338 were up-regulated and down-regulated, respectively. No 31843366 chr4_105399164_105370837_-28327 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 301 were up-regulated and down-regulated, respectively. No 31843366 chr4:147227078-147230127- CircRNA Homo sapiens Ovarian Neoplasms Serum Expression [differentially expressed] qRT-PCR//circRNA-seq//RNA-seq These 5 circRNAs exhibited increased differential expression in OC compared with normal samples. No 31589961 chr3_68989017_68988269_-748 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 419 were up-regulated and down-regulated, respectively. No 31843366 chr3_67750660_67746771_-3889 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 316 were up-regulated and down-regulated, respectively. No 31843366 chr3_66263379_66243203_-20176 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 475 were up-regulated and down-regulated, respectively. No 31843366 chr3_56673725_56623644_-50081 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 356 were up-regulated and down-regulated, respectively. No 31843366 chr3_52741499_52737586_-3913 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 379 were up-regulated and down-regulated, respectively. No 31843366 chr3_52662276_52658199_-4077 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 389 were up-regulated and down-regulated, respectively. No 31843366 chr3_3140648_3137260_-3388 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 386 were up-regulated and down-regulated, respectively. No 31843366 chr3_28492173_28413056_-79117 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 363 were up-regulated and down-regulated, respectively. No 31843366 chr3_185626393_185598412_-27981 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 373 were up-regulated and down-regulated, respectively. No 31843366 chr3_18420991_18415111_-5880 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 367 were up-regulated and down-regulated, respectively. No 31843366 chr3_184182248_184178857_-3391 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 488 were up-regulated and down-regulated, respectively. No 31843366 chr3_171709709_171686685_-23024 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 342 were up-regulated and down-regulated, respectively. No 31843366 chr3_146124229_146121112_-3117 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 287 were up-regulated and down-regulated, respectively. No 31843366 chr3_143989832_143985543_-4289 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 445 were up-regulated and down-regulated, respectively. No 31843366 chr3_136423044_136422410_-634 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 262 were up-regulated and down-regulated, respectively. No 31843366 chr3_13502980_13500713_-2267 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 253 were up-regulated and down-regulated, respectively. No 31843366 chr3_129880562_129827803_-52759 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 437 were up-regulated and down-regulated, respectively. No 31843366 chr3_125021130_124997689_-23441 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 463 were up-regulated and down-regulated, respectively. No 31843366 chr22_27897892_27873738_-24154 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 299 were up-regulated and down-regulated, respectively. No 31843366 chr21_36372532_36362179_-10353 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 505 were up-regulated and down-regulated, respectively. No 31843366 chr20_50130947_50127975_-2972 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 414 were up-regulated and down-regulated, respectively. No 31843366 chr20_47294779_47291796_-2983 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 298 were up-regulated and down-regulated, respectively. No 31843366 chr2_152135603_152123766_-11837 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 439 were up-regulated and down-regulated, respectively. No 31843366 chr2_101033758_101021681_-12077 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 359 were up-regulated and down-regulated, respectively. No 31843366 chr12_91178585_91164605_-13980 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 322 were up-regulated and down-regulated, respectively. No 31843366 chr15_50663046_50631417_-31629 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 387 were up-regulated and down-regulated, respectively. No 31843366 chr15_44657263_44626331_-30932 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 409 were up-regulated and down-regulated, respectively. No 31843366 chr15_42442414_42428018_-14396 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 247 were up-regulated and down-regulated, respectively. No 31843366 chr15_38505920_38502312_-3608 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 441 were up-regulated and down-regulated, respectively. No 31843366 chr15_34867609_34860042_-7567 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 300 were up-regulated and down-regulated, respectively. No 31843366 chr15_30976955_30967920_-9035 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 494 were up-regulated and down-regulated, respectively. No 31843366 chr15_29734382_29726379_-8003 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 315 were up-regulated and down-regulated, respectively. No 31843366 chr14_91895072_91891221_-3851 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 252 were up-regulated and down-regulated, respectively. No 31843366 chr14_91199905_91188910_-10995 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 474 were up-regulated and down-regulated, respectively. No 31843366 chr14_90730196_90689540_-40656 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 495 were up-regulated and down-regulated, respectively. No 31843366 chr14_67323812_67269701_-54111 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 402 were up-regulated and down-regulated, respectively. No 31843366 chr14_67303599_67301389_-2210 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 508 were up-regulated and down-regulated, respectively. No 31843366 chr14_52874226_52860341_-13885 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 372 were up-regulated and down-regulated, respectively. No 31843366 chr14_50486194_50475077_-11117 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 466 were up-regulated and down-regulated, respectively. No 31843366 chr14_34862322_34826013_-36309 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 506 were up-regulated and down-regulated, respectively. No 31843366 chr14_30653588_30628209_-25379 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 418 were up-regulated and down-regulated, respectively. No 31843366 chr14_23389719_23389393_-326 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 254 were up-regulated and down-regulated, respectively. No 31843366 chr14_105479047_105478266_-781 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 236 were up-regulated and down-regulated, respectively. No 31843366 chr13_41887361_41865736_-21625 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] qRT-PCR//RNA-seq Among the 280 circRNAs, 46 and 401 were up-regulated and down-regulated, respectively. No 31843366 chr13_41703411_41685047_-18364 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 465 were up-regulated and down-regulated, respectively. No 31843366 chr13_41260915_41252645_-8270 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 500 were up-regulated and down-regulated, respectively. No 31843366 chr13_35070852_35040933_-29919 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 393 were up-regulated and down-regulated, respectively. No 31843366 chr13_32537027_32517857_-19170 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 327 were up-regulated and down-regulated, respectively. No 31843366 chr13_30283791_30280063_-3728 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 288 were up-regulated and down-regulated, respectively. No 31843366 chr13_20983806_20983224_-582 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 485 were up-regulated and down-regulated, respectively. No 31843366 chr13_111233293_111205289_-28004 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 416 were up-regulated and down-regulated, respectively. No 31843366 chr13_101292366_101229393_-62973 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 308 were up-regulated and down-regulated, respectively. No 31843366 chr13_100368574_100301460_-67114 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] qRT-PCR//RNA-seq Among the 280 circRNAs, 46 and 450 were up-regulated and down-regulated, respectively. No 31843366 chr12_95296258_95251940_-44318 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 353 were up-regulated and down-regulated, respectively. No 31843366 chr12_9153343_9074560_-78783 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 234 were up-regulated and down-regulated, respectively. No 31843366 chr15_49590007_49568245_-21762 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 317 were up-regulated and down-regulated, respectively. No 31843366 chr15_52410476_52375304_-35172 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 469 were up-regulated and down-regulated, respectively. No 31843366 chr19_5654456_5653115_-1341 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 420 were up-regulated and down-regulated, respectively. No 31843366 chr15_57461892_57451500_-10392 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 265 were up-regulated and down-regulated, respectively. No 31843366 chr19_5047669_5016257_-31412 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 473 were up-regulated and down-regulated, respectively. No 31843366 chr19_40583717_40583398_-319 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 408 were up-regulated and down-regulated, respectively. No 31843366 chr19_33094269_33093359_-910 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 328 were up-regulated and down-regulated, respectively. No 31843366 chr18_6312056_6301903_-10153 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 496 were up-regulated and down-regulated, respectively. No 31843366 chr18_6312056_6138194_-173862 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 427 were up-regulated and down-regulated, respectively. No 31843366 chr18_6244588_6171828_-72760 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 266 were up-regulated and down-regulated, respectively. No 31843366 chr18_36602768_36576451_-26317 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 399 were up-regulated and down-regulated, respectively. No 31843366 chr17_82587272_82582741_-4531 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 404 were up-regulated and down-regulated, respectively. No 31843366 chr17_68452992_68450728_-2264 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 280 circRNAs, 46 and 268 were up-regulated and down-regulated, respectively. No 31843366 chr17_58709990_58694931_-15059 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 293 were up-regulated and down-regulated, respectively. No 31843366 chr17_31374129_31349120_-25009 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 282 were up-regulated and down-regulated, respectively. No 31843366 chr17_19936430_19920036_-16394 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 458 were up-regulated and down-regulated, respectively. No 31843366 chr17_17264981_17261966_-3015 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 510 were up-regulated and down-regulated, respectively. No 31843366 chr16_89431326_89418284_-13042 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 486 were up-regulated and down-regulated, respectively. No 31843366 chr16_8930397_8929369_-1028 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 432 were up-regulated and down-regulated, respectively. No 31843366 chr16_80685129_80684538_-591 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 492 were up-regulated and down-regulated, respectively. No 31843366 chr16_70268379_70258980_-9399 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 403 were up-regulated and down-regulated, respectively. No 31843366 chr16_68123121_68121987_-1134 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 406 were up-regulated and down-regulated, respectively. No 31843366 chr16_67066798_67036639_-30159 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 438 were up-regulated and down-regulated, respectively. No 31843366 chr16:53175091-53191453+ CircRNA Homo sapiens Ovarian Neoplasms Serum Expression [differentially expressed] qRT-PCR//circRNA-seq//RNA-seq These 5 circRNAs exhibited increased differential expression in OC compared with normal samples. No 31589961 chr15_94298730_94298201_-529 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 366 were up-regulated and down-regulated, respectively. No 31843366 chr15_65481615_65463761_-17854 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 339 were up-regulated and down-regulated, respectively. No 31843366 chr15_63574403_63529014_-45389 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 370 were up-regulated and down-regulated, respectively. No 31843366 chr15_63563008_63542055_-20953 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 314 were up-regulated and down-regulated, respectively. No 31843366 chr15_62035052_61991000_-44052 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 290 were up-regulated and down-regulated, respectively. No 31843366 chr15_59218087_59195461_-22626 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 447 were up-regulated and down-regulated, respectively. No 31843366 chr15_58166796_58138447_-28349 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 349 were up-regulated and down-regulated, respectively. No 31843366 chr15_57639545_57604269_-35276 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 396 were up-regulated and down-regulated, respectively. No 31843366 chr15_57625892_57618033_-7859 CircRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 280 circRNAs, 46 and 258 were up-regulated and down-regulated, respectively. No 31843366 CDKN2B-AS1 LncRNA Homo sapiens Glaucoma Three hundred and forty-six glaucoma patients and 263 healthy controls Mutation(rs2383207, rs564398, rs2157719, rs7865618, rs4977574 ) Genotyping No 35028972 CDKN2B-AS1 LncRNA Homo sapiens Plaque, Atherosclerotic atherosclerotic plaque tissues interaction[CDKN2B ] qRT-PCR//RNA Pull-Down//RIP//ChIP CDKN2B-AS1 showed high expression levels in atherosclerosis, whereas CDKN2B showed low expression levels. The results demonstrated that CDKN2B-AS1 promotes atherosclerotic plaque formation and inhibits mRCT in atherosclerosis by regulating CDKN2B promoter, and thereby could be a potential therapeutic target for atherosclerosis. No 32335370 ATP5ME LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 C20orf204 LncRNA Homo sapiens Pancreatic Neoplasms blood Expression[highly expressed] qRT-PCR After selection and validation, three characteristic plasma candidate lncRNAs, ABHD11-AS1, LINC00176 and SNHG12, were identified, and their levels were significantly higher in PC patients than in normal controls. No 31333792 C1QTNF9B‐AS1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)114) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 C18orf54 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 C16orf87 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 C14orf63 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)90) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 C11orf58-206 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 C10orf143 LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[highly expressed] qRT-PCR Our results revealed that Linc00959 expression was correlated with ER status (p = 0.005), PR status (p = 0.036), Ki67 (p = 0.025) and HER2 status (p = 0.009). The Kaplan-Meier survival curves indicated that the overall survival (OS) (p = 0.022) and relapse-free survival (RFS) (p = 0.002) were significantly poor in high Linc00959 expression BC patients (p = 0.023). Furthermore, the survival analysis by Cox regression showed that Linc00959 served as an independent prognostic marker in breast cancer (p = 0.004). Our results revealed that Linc00959 expression was correlated with ER status (p = 0.005), PR status (p = 0.036), Ki67 (p = 0.025) and HER2 status (p = 0.009). The Kaplan-Meier survival curves indicated that the overall survival (OS) (p = 0.022) and relapse-free survival (RFS) (p = 0.002) were significantly poor in high Linc00959 expression BC patients (p = 0.023). Furthermore, the survival analysis by Cox regression showed that Linc00959 served as an independent prognostic marker in breast cancer (p = 0.004). No 30828265 BX640700 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[lower expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 BX538226 LncRNA Homo sapiens Arthritis, Gouty blood Expression[lower expressed] qRT-PCR//Microarray A total of 465 mRNAs were upregulated and 506 mRNAs were downregulated in the GA patients compared with those in the HC group (Fig. 1B). Table II presents the 10 most upregulated and downregulated lncRNAs in the GA patients vs. HC group. No 31452697 BX284613.2-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 BUD23 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 BTG1P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 548 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 BTF3P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 853 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 BTF3-204 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 BRMS1 LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-19A) Expression[no-differently] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD13 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 BRE-AS1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 611 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 BRD3OS LncRNA Homo sapiens Skin Neoplasms tumor cells and tissues Expression(highly expressed) In Vivo Experiment//qRT-PCR//RNA-seq//Western Blot Higher BRD3OS (LINC00094) expression was noted in metastatic cSCCs than in non-metastatic cSCCs. No 36010973 BNC2-AS1-201 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 BNC2-AS1-201 LncRNA Homo sapiens Adrenocortical Carcinoma ACC tissues Expression[lower expressed] qRT-PCR//Microarray In these samples, 874 lncRNAs were differentially expressed in ACC compared with NAC, of which 409 were upregulated, and 465 were downregulated. The 874 differentially expressed lncRNAs corresponded to 330 annotated lncRNA genes. Among the upregulated lncRNAs, the greatest log2 fold change was 8.5 for an unannotated lncRNA gene, and RAD50 was the geratest upregulated, annotated lncRNA gene with a log2 fold change of 6.1. Among the downregulated lncRNAs, the greatest log2 fold change was 8.3 for an unannotated lncRNA gene and 6.4 for HAND2, the greatest downregulated annotated lncRNA gene; of these, 183 differently expressed lncRNAs had established functions in cancer development and cancer progression. Selected carcinogenesis-related lncRNAs are summarized in Table 2. No 31522749 BNC2-AS1 LncRNA Homo sapiens gastric adenocarcinoma GA tissues Expression[differently expression] qRT-PCR//Microarray The expression of 5 differentially expressed lncRNAs, HNF1A-AS1, RP11-62F24.2, GAS5, MALAT1, and H19 were randomly selected to be measured in 47 patients using real-time quantitative reverse transcription PCR (qRT-PCR), and the data were consistent with those obtained from the microarray chip. No 31850717 BMP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 BLOC1S6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 BLOC1S1-RDH5 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 BLOC1S1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 BLNK LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 BLACAT1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 BLACAT1 LncRNA Homo sapiens Thyroid Cancer, Papillary plasma Expression [lower expressed] CCK8//qRT-PCR//Transwell Assay//Bioinformatics Analysis//ChIP BLACAT1 expression was downregulated in the plasma of case group compared with control group (P = 0.003). We also found that low plasma BLACAT1 expression was correlated with lymph node metastasis (LNM) (P < 0.001). Multivariate analysis showed that BLACAT1 was an independent risk factor for lymph node metastasis and gender (P < 0.05). The area under the ROC curve for BLACAT1 was 0.825 in LNM prediction (P < 0.001). No 29599647 BLACAT1 LncRNA Homo sapiens Osteosarcoma cell lines regulation[ BLACAT1/miR-608/SOX12 axis] Western Blot//Wound Healing Assay//Tunel//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay BLACAT1 was highly expressed in osteosarcoma. This study highlighted the contribution of BLACAT1/miR-608/SOX12 axis to the progression of osteosarcoma, suggesting novel targets for osteosarcoma therapy. No 33005563 BLACAT1 LncRNA Homo sapiens Leukemia, Myeloid, Acute AML patients Expression[highly expressed] qRT-PCR The expression of lncRNA BLACAT1 in AML patients was significantly higher than that in complete remission patients and iron deficiency anemia patients, but the expression of lncRNA BLACAT1 in AML-CR group and control group had no significant difference. No 32255290 BLACAT1 LncRNA Homo sapiens Glioma glioma samples Expression(highly expressed) qRT-PCR The relative expression of BLACAT1 in glioma samples was significantly higher than that of matched normal tissues (P < .001). The expression level of tissue BLACAT1 was statistically correlated with tumor size (P = .04), Karnofsky Performance Status (KPS) (P = .006), and WHO grade (P = .017). Kaplan-Meier analysis with the log-rank test revealed that BLACAT1 up-regulation was correlated with shorter overall survival time of patients with glioma (Log Rank test, P = .012). No 33725920 C1RL-AS1 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck TCGA Regulation qRT-PCR Then, we recognized a set of six FElncRNAs PFLS (SLCO4A1-AS1, C1RL-AS1, PCED1B-AS1, HOXB-AS3, MIR9-3HG, and SFTA1P) for predicting patients' prognostic risks and survival outcomes. Notably, the low-risk group of the PFLS showed a higher MHC score and cytolytic activity (CYT) score than the high-risk group, implying the low-risk group may have greater tumor surveillance and killing ability.  No 34976018 C21orf91-OT1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 928 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 BISPR LncRNA Homo sapiens Endometrial Neoplasms Serum and tissue samples Expression(highly expressed) RNA-seq At the same time, lncRNA sequencing results showed that when endometrial atypical hyperplasia continued to change, including LINC00511, PVT1, and IQCH-AS1 (downregulated), and only changed significantly in the endometrial dysplasia group, including MALAT1, CARMN (downregulated) and LINC00648, BISPR, LINC01534, and LINC00930 (upregulated). No 36510632 C22orf34-204 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CARIntergenic10 LncRNA Homo sapiens Adenocarcinoma of Lung Lung adenocarcinoma tissues Expression[highly expressed] qRT-PCR//Microarray Notably, 12 lncRNAs had levels increased by >5 times and 121 lncRNAs had levels decreased by >5 times in tumor tissues than in adjacent tissues (Tables 3 and ?and44). No 30233202 CARD8-AS1 LncRNA Homo sapiens Mucocutaneous Lymph Node Syndrome Han Chinese population Mutation(rs7248320 ) Genotyping his study suggests for the first time that the lncRNA AC008392.1 rs7248320 polymorphism may be involved in KD susceptibility in the Han Chinese population. No 34584439 CARD14 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CAR10 LncRNA Homo sapiens Adenocarcinoma of Lung LUAD tissues Regulation[ miR-203/30/SNAI axis] RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Microarray//Colony Formation Assay//Transwell Assay Here, we found that lncRNA chromatin-associated RNA 10 (CAR10) was upregulated in the tumor tissue of patients with LUAD and enhanced tumor metastasis in vitro and in vivo. In conclusion, the CAR10/miR-30/203/SNAI axis is a novel and potential therapeutic target for LUAD. CAR10 overexpression was positively correlated with a poor prognosis in LUAD patients, whereas overexpression of both CAR10 and SNAI was correlated with even worse clinical outcomes. No 30617305 CAPZB-207 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CAP2P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 961 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 CANX-210 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 CAMK1D LncRNA Homo sapiens brain glioma brain glioma tissues Expression[lower expressed] qRT-PCR Consistent with the microarray data, qPCR confirmed differential expression of these 6 lncRNAs (ak125809, ak098473, uc002ehu.1, bc043564, NR_027322, and uc003qmb.2) between tumor and peritumoral tissue. No 32051722 CALU LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CALML3-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CALM1-211 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 CALCOCO1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CAIF LncRNA Homo sapiens Cardiomyopathies blood Expression[lower expressed] qRT-PCR Downregulated CAIF was observed in end-stage cardiomyopathy patients than in healthy controls. CAIF expression distinguished end-stage cardiomyopathy patients from healthy controls and predict the survival of patients. No 31587591 CAHM LncRNA Homo sapiens Glioma glioma cells Regulation(SPAK/JNK Pathway) Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//qRT-PCR//MTT//Invasion Assay//IF In glioma cells, CAHM is hypermethylated by DNA methyltransferase1 (DNMT1) and the loss of CAHM expression could be reversed by 5-Aza-2'-deoxycytidine (5-Aza), a specific inhibitor of DNA methyltransferases. Besides, the expression of CAHM was negatively associated with overall survival in both primary and recurrent gliomas. Overexpression of CAHM inhibited glioma cell proliferation, clone formation, and invasion. Further exploring results showed that CAHM overexpression suppressed glioma migration and invasion through SPAK/MAPK pathway. We found that CAHM expression was correlated with glioma grades, molecular subtype, IDH mutation status, and 1q/19p codel status. No 34227028 CAF LncRNA Homo sapiens Stomach Neoplasms ESCC and GC tissues Regulation(HIF1A) qRT-PCR A significant reduction in FLJ22447 expression was observed in ESCC and GC tissues than adjacent non-tumor tissues, while, the expression of HIF1A and VEGF were increased. Low expression of FLJ22447 was significantly correlated with HIF1A (P = 2.4e-73, R = 0.63) and VEGF (P = 0.00019, R = 0.15) expression. A significant relationship was detected between the high expression of HIF1A and tumor stages (I-II) and it was related to the reduced survival of ESCC patients. Conversely, increased VEGF expression was linked to the advanced stages (III-IV) and metastasis in ESCC. The analysis of FLJ22447-interacted proteins showed that MYC, JUN, SMRCA4, PPARG, AR, FOS, and CEBPA are the hub genes. These proteins were implicated in the cancer related pathways. Among them, SPI1, E2F1, TCF7L2, and STAT1 were significantly expressed in esophageal and gastric cancers that were functionally involved in the proliferation, apoptosis, and angiogenesis pathways in cancer. A significant relationship was detected between the high expression of HIF1A and tumor stages (I-II) and it was related to the reduced survival of ESCC patients. No 35040008 CAF LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma ESCC and GC tissues Regulation(HIF1A) qRT-PCR A significant reduction in FLJ22447 expression was observed in ESCC and GC tissues than adjacent non-tumor tissues, while, the expression of HIF1A and VEGF were increased. Low expression of FLJ22447 was significantly correlated with HIF1A (P = 2.4e-73, R = 0.63) and VEGF (P = 0.00019, R = 0.15) expression. A significant relationship was detected between the high expression of HIF1A and tumor stages (I-II) and it was related to the reduced survival of ESCC patients. Conversely, increased VEGF expression was linked to the advanced stages (III-IV) and metastasis in ESCC. The analysis of FLJ22447-interacted proteins showed that MYC, JUN, SMRCA4, PPARG, AR, FOS, and CEBPA are the hub genes. These proteins were implicated in the cancer related pathways. Among them, SPI1, E2F1, TCF7L2, and STAT1 were significantly expressed in esophageal and gastric cancers that were functionally involved in the proliferation, apoptosis, and angiogenesis pathways in cancer. A significant relationship was detected between the high expression of HIF1A and tumor stages (I-II) and it was related to the reduced survival of ESCC patients. No 35040008 CADM3-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CADM1-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues Expression[Expression[lower expressed]-expression] qRT-PCR The expression of lncRNA CADM1-AS1 was significantly decreased in tumor tissues. According to the mean expression of lncRNA CADM1-AS1, the patients were divided into a high expression groExpression[Expression[up-expression]-expression] and a low expression groExpression[Expression[up-expression]-expression], and the expression of lncRNA CADM1-AS1 in gastric cancer was significantly correlated with tumor differentiation, N stage, M stage, and TNM stage. Moreover, the gastric cancer patients with higher expression of lncRNA CADM1-AS1 had a statistically better overall survival (OS) time and progression-free survival (PFS) time. No 31389606 CACNG6 LncRNA Homo sapiens Depression depression patients' blood samples Expression [lower expressed] Microarray  As a result, a total of 340 circRNAs, 398 lncRNAs, 206 miRNAs, and 92 mRNAs were differentially expressed between the depression and control groups.  No 34650925 CACNA1G-AS1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues Epigenetics(hypo-methylated ) qRT-PCR//Bioinformatics Analysis Significant negative correlation was observed between 8 DElncRNAs-DMCs pairs. 3 (cg23614229, cg23957912, and cg11052780) DMCs and 4 (CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1) DElncRNAs were identified as high-risk factors for poor prognosis of PC patients. Overexpression of hypo-methylated CACNA1G-AS1, F11-AS1, and NNT-AS1 and down-regulation of hyper-methylated MSC-AS1 significantly lower the survival of PC patients and could be a potential prognostic and therapeutic biomarker. No 35715447 CACNA1C-IT3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 646 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 CABLES1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CAAP1-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CA3‐AS1 LncRNA Homo sapiens Colonic Neoplasms COAD tissues Expression[lower expressed] qRT-PCR "To manifest the expression of integrated analysis, we selected the previously obtained eight biomarkers including XXbac‐ B476C20.9, PP7080, CDKN2B‐AS1, LINC00092, CA3‐AS1, HAND2‐AS1, CTD‐2269F5.1, and LINC01082. In Figure 8, these eight selected DElncRNAs for qRT‐PCR confirmation were eight optimal diagnostic lncRNA biomarkers, and these eight DElncRNAs were all downregulated in the high‐ throughput transcriptome datasets for COAD compared with normal controls. The expression of these selected eight genes in qRT‐PCR was consistent with our integrated analysis." No 30269368 C9orf163 LncRNA Homo sapiens Breast Neoplasms TCGA(1,104 tumor samples and 292 normal samples) Regulation Bioinformatics Analysis In total, five metabolism-related lncRNAs were enrolled to establish prognostic signatures. Further analysis demonstrated that the signature was an independent prognostic factor for BC. No 34254565 C5orf64 LncRNA Homo sapiens Adenocarcinoma of Lung Tregs and plasma cells Regulation Survival Analysis A 14-lncRNA immune-related signature was developed, among which C5orf64 was found to be positively correlated with abundances of M2 macrophages, monocytes, eosinophils and neutrophils, but negatively correlated with Tregs and plasma cells. No 33309768 C5orf22 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 C4orf46 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 C2orf92 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung Serum exosomal Expression(highly expressed) qRT-PCR//Luciferase Report Assay We identified 90 dysregulated lncRNAs for NSCLC and found the most significant lncRNA was a novel isoform of linc01125. Serum exosomal linc01125 could distinguish NSCLC cases from disease-free and tuberculosis controls, with the area under the curve values as 0.662 [95% confidence interval (CI) = 0.614-0.711] and 0.624 (95% CI = 0.522-0.725), respectively. High expression of exosomal linc01125 was also correlated with an unfavorable overall survival of NSCLC (hazard ratio = 1.48, 95% CI = 1.05-2.08). No 33928340 BLACAT1 LncRNA Homo sapiens Prostatic Neoplasms prostate cancer tissues, cell lines interaction[sponging miR-361] qRT-PCR//Luciferase Report Assay//RIP In patient samples and prostate cancer cell lines, BLACAT1 was down-regulated and inversely proportional to DNMT1, HDAC1, EZH2, MDM2 and miR-361 expression. The BALCAT1 promoter was methylated in prostate cancer tissue and found to interact with miR-361 via luciferase assays. No 31957820 BISPR LncRNA Homo sapiens Sjogren's Syndrome blood Expression[highly expressed] qRT-PCR//RNA-seq Among all the 1772 tested LncRNAs, 44 LncRNAs were expressed aberrantly as found in this study, including 26 up-regulated and 18 down-regulated, and the top 10 up-regulated and down-regulated LncRNAs are listed in Table ?Table2.2. No 33184486 CARMN LncRNA Homo sapiens Aortic Aneurysm, Thoracic aortic tissue Expression[lower expressed] qRT-PCR We found significantly reduced CARMN (p = 0.033) and LUCAT1 (p = 0.009) expression in aortic tissue samples from TAA patients. Relative expression of MALAT1 (p = 0.117) and SMILR (p = 0.610) did not differ in aortic tissue between the TAA and non-TAA groups. Expression of both LUCAT1 and SMILR was significantly decreased in TAA patients' blood plasma compared to controls (p = 0.018 and p = 0.032, respectively). No 32655720 BANCR LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck laryngeal squamous carcinoma tissues,cell lines Expression[highly expressed] CCK8//qRT-PCR BANCR was highly expressed in laryngeal squamous carcinoma tissues and cells. No 31798630 BANCR LncRNA Homo sapiens Carcinoma Expression[highly expressed] Meta-analysis The results showed that elevated BANCR expression was associated with unfavorable prognosis for most cancer patients, and BANCR could serve as a promising therapeutic target and independent prognostic predictor in most of cancer types. No 32907530 BANCR LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 BACH1 LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-23A) Expression[no-differently] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD17 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 BACH1 LncRNA Homo sapiens Triple Negative Breast Neoplasms TNBC tissue Regulated[up-regulated] IHC These findings provide further insight into the expression pattern of MALAT1 and BACH1 in TNBC and suggest them as prognostic biomarkers for TNBC. No 31939443 BACE1-AS LncRNA Homo sapiens Alzheimer Disease blood Expression[highly expressed] qRT-PCR The BACE1-AS level was low in pre-AD subgroup but it was high in full-AD people compared to the healthy controls. The BACE1-AS level was low in pre-AD subgroup but it was high in full-AD people compared to the healthy controls. Moreover, ROC curve analysis revealed that lncRNA BACE1-AS may discriminate pre-AD and healthy control (75% sensitivity and 100% specificity), full-AD and healthy control (68% sensitivity and 100% specificity), and pre-AD and full-AD subgroups (78% sensitivity and 100% specificity), highlighting its potential as a biomarker for AD development. In conclusion, plasma BACE1-AS level may serve as a potent blood-based biomarker for Alzheimer's disease. No 31264051 BACE1-AS LncRNA Homo sapiens Atherosclerosis plasma of patients Interaction(BACE1 ) qRT-PCR//Microarray In the cross-sectional arm, BACE1-AS expression correlated with BACE1 expression (r = 0.396, p < 0.001) and marginally with Aβ1-40 levels in plasma (r = 0.141, p = 0.008). Higher BACE1-AS was associated with higher estimated CVD risk assessed by HeartScore for non-CVD subjects and by European Society of Cardiology clinical criteria for the total population (p < 0.05 for both). BACE1-AS was associated with higher prevalence of CAD (odds ratio [OR] = 1.85, 95% confidence interval [CI]: 1.37-2.5), multivessel CAD (OR = 1.36, 95% CI: 1.06-1.75), and with higher number of diseased vascular beds (OR = 1.31, 95% CI: 1.07-1.61, for multiple diseased vascular beds) after multivariable adjustment for traditional cardiovascular risk factors. In the prospective arm, BACE1-AS was an independent predictor of MACE in high cardiovascular risk patients (adjusted hazard ratio = 1.86 per ascending tertile, 95% CI: 1.011-3.43, p = 0.046). Higher BACE1-AS was associated with higher estimated CVD risk assessed by HeartScore for non-CVD subjects and by European Society of Cardiology clinical criteria for the total population (p < 0.05 for both). BACE1-AS was associated with higher prevalence of CAD (odds ratio [OR] = 1.85, 95% confidence interval [CI]: 1.37-2.5), multivessel CAD (OR = 1.36, 95% CI: 1.06-1.75), and with higher number of diseased vascular beds (OR = 1.31, 95% CI: 1.07-1.61, for multiple diseased vascular beds) after multivariable adjustment for traditional cardiovascular risk factors. In the prospective arm, BACE1-AS was an independent predictor of MACE in high cardiovascular risk patients (adjusted hazard ratio = 1.86 per ascending tertile, 95% CI: 1.011-3.43, p = 0.046). No 35915966 BABAM1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 BAALC-AS1-214 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 B476C20.9 LncRNA Homo sapiens Colonic Neoplasms COAD tissues Expression[lower expressed] qRT-PCR "To manifest the expression of integrated analysis, we selected the previously obtained eight biomarkers including XXbac‐ B476C20.9, PP7080, CDKN2B‐AS1, LINC00092, CA3‐AS1, HAND2‐AS1, CTD‐2269F5.1, and LINC01082. In Figure 8, these eight selected DElncRNAs for qRT‐PCR confirmation were eight optimal diagnostic lncRNA biomarkers, and these eight DElncRNAs were all downregulated in the high‐ throughput transcriptome datasets for COAD compared with normal controls. The expression of these selected eight genes in qRT‐PCR was consistent with our integrated analysis." No 30269368 B3GALT5-AS1-204 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[lower expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Of them, 200 lncRNAs and 1561 mRNAs were upregulated while 146 lncRNAs and 1032mRNAs were downregulated. We respectively listed top 20 dysregulated lncRNAs and mRNAs in Tables 1 and 20. No 31619123 B3GALT5-AS1 LncRNA Homo sapiens Stomach Neoplasms blood Expression[highly expressed] qRT-PCR The result demonstrated that B3GALT5-AS1 level was markedly richer in GC patients than that in normal people (P < .001). B3GALT5-AS1 may be served as a diagnostic marker for distinguishing GC patients from healthy people, and the proportion under the receiver operating characteristics curve is 0.816 (95% confidence interval, 0.758-0.874; P = .03). Further exploration validated that high serum B3GALT5-AS1 level was related to TNM stage (P = .024), and lymph node metastasis (P = .023). No 31338903 B3GALT5-AS1 LncRNA Homo sapiens Colorectal Neoplasms CRC tissue Expression[lower expressed] Western Blot//Colony Formation Assay//CCK8//qRT-PCR//RNA-seq//IHC Then, we showed that the expression levels of PGM5-AS1, B3GALT5-AS1 and PGM6 were significantly downregulated in CRC tissues compared with corresponding normal tissues. No 31619123 B3GALT5-AS1 LncRNA Homo sapiens Colorectal Neoplasms Serum Expression[lower expressed] qRT-PCR The level of B3GALT5-AS1 in CRC patients was significantly lower than that of healthy patients (p < 0.0001). Further exploration validated that high serum B3GALT5-AS1 level was related to tumor node metastasis (TNM) stage (p = 0.008) and histological differentiation (p = 0.027). Compared with the healthy control group, AUCROC of serum B3GALT5-AS1 in the CRC group was 0.762 with 95% CI: 0.698-0.826 (p < 0.0001). No 32207329 AY927503 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues,cell lines Interaction[ITGAV] RNA Pull-Down//Western Blot//ISH//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//ChIP We identified lncRNA AY927503 (AY) as a metastasis-associated molecule that was highly expressed in human hepatocellular carcinoma (HCC) and correlated with metastatic events and poor prognosis in patients with HCC. . AY significantly enriched H3K4Me3 and acH3K9/14 but reduced H3K27Me3 and H1FX occupancy on the ITGAV promoter, which remodeled chromatin structures for RNA polymerase II recruitment. Knockdown of H1FX abrogated ITGAV transcription stimulated by AY. No 31285770 AXL CircRNA Homo sapiens Alzheimer Disease cerebrospinal fluid Expression[highly expressed] qRT-PCR//Microarray By RT-qPCR, circ-LPAR1, circ-AXL and circ-GPHN were increased, whereas circ-PCCA, circ-HAUS4, circ-KIF18B and circ-TTC40C were decreased in AD patients compared with Ctrl subjects, and these circRNAs were disclosed to predict AD risk by receiver operating characteristics curve analysis. No 32315771 AXDND1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 AX747742 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[lower expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)15) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 AWPPH LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung blood Regulated[up-regulated] qRT-PCR Patient were divided into 3 groups - a non-recurrence group (NR, n=54), a local recurrence group (LR, n=42), and a distant recurrence (DR, n=32) group - according to the follow-up results. Blood AWPPP was detected by qRT-PCR. Blood AWPPH levels were the highest in the DR group, followed by the LR and NR groups. The lowest blood AWPPH levels were observed in the control group. Blood AWPPH levels increased significantly in the DR group but not in the NR and LR groups during follow-up. Blood AWPPH levels were positively correlated with TGF-ß1 mRNA levels in the DR group but not in the NR and LR groups during follow-up. AWPPH overexpression promoted cell migration and invasion and upregulated TGF-ß1 expression. No 30953582 AWPPH LncRNA Homo sapiens Glioma blood Interaction[upregulation of HIF1α] Western Blot//Migration Assay//qRT-PCR//Invasion Assay//Transwell Assay Compared with patients with non-metastatic glioma and healthy controls, significantly increased plasma levels of AWPPH were observed in patients with metastatic glioma (P<0.05; Fig. 1). However, no significant differences in plasma levels of AWPPH were identified between patients with non-metastatic glioma and healthy controls (Fig. 1). The diagnostic value of AWPPH for glioma was analyzed by ROC curve analysis. For metastatic glioma with healthy controls as references, the area under the curve (AUC) was 0.8640 [standard error, 0.03950; 95% confidence interval (CI), 0.7865–0.9414; P<0.0001; Fig. 2A]. For metastatic glioma with patients with non-metastatic glioma as references, the AUC was 0.7881 (standard error, 0.05451; 95% CI, 0.6813–0.8950; P<0.0001; Fig. 2B). For non-metastatic glioma with healthy controls as references, the AUC was 0.6186 (standard error, 0.06578; 95% CI, 0.4896–0.7476; P=0.07899). No 31807187 AWPPH LncRNA Homo sapiens Coronary Artery Disease blood Expression[highly expressed] qRT-PCR It was found that lncRNA-AWPPH was highly expressed in serum of CAD patients, especially those receiving rosuvastatin therapy. No 33275243 AURKAP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 AUP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 AU020206-201 LncRNA Mus musculus Myocardial Reperfusion Injury left ventricle Expression[lower expressed] qRT-PCR//RNA-seq//Western Blot To identify differentially expressed mRNAs, lncRNAs, and circRNAs between the MIRI and sham groups, we used RNA sequencing. The results showed that a total of 162 mRNAs were differentially expressed with a >2-fold change, with p < 0.05. Among them, 64 mRNAs were upregulated and 98 mRNAs were downregulated, and there were 20 differentially expressed lncRNAs. There were 10 upregulated and 10 downregulated lncRNAs. The top 10 up- and downregulated mRNAs and lncRNAs are listed in Table 13. No 30974198 ATXN8OS LncRNA Homo sapiens Breast Neoplasms BC tissues and cells Expression[highly expressed] qRT-PCR ATXN8OS expression was increased in BC tissues and cells. No 33385064 ATXN1 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 ATP8A2P3 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 972 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 ATP6V1E1-205 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 ATP5PF-208 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 BANCR LncRNA Homo sapiens Hearing Loss, Noise-Induced blood Expression[lower expressed] qRT-PCR LncRNAs were verified by qRT-PCR, namely, LOC101928211, LOC101928804, and BANCR. The expression of LOC101928211 and LOC101928804 in the NIHL group was significantly higher than that in the exposed group, while the expression of BANCR was obviously decreased (P<0.001). No 31807550 BANCR LncRNA Homo sapiens Pancreatic Neoplasms pancreatic cancer tissues and cell lines Regulation[MiR-195-5p/Wnt/β-Catenin Signaling Pathway] qRT-PCR//Luciferase Report Assay We identified that BRAF-activated noncoding RNA was upregulated in pancreatic cancer tissues and cell lines, and BRAF-activated noncoding RNA was related to tumor metastasis and stage.Furthermore, miR-195-5p inhibitor abrogated the effects of short-interfering BRAF-activated noncoding RNA on PANC-1 and SW1990 cell growth and invasion in vitro. We further identified that BRAF-activated noncoding RNA played a vital role in activating the Wnt/β-catenin pathway by sponging miR-195-5p. Collectively, our study showed that BRAF-activated noncoding RNA promotes pancreatic cancer tumorigenesis through miR-195-5p/Wnt/β-catenin axis may serve as a potential target for diagnostics and therapeutics in pancreatic cancer. We identified that BRAF-activated noncoding RNA was upregulated in pancreatic cancer tissues and cell lines, and BRAF-activated noncoding RNA was related to tumor metastasis and stage. No 31769353 BIRC6 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 BANCR LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[highly expressed] RNA-seq Among the 557 lncRNAs, 30 and 866 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 BIRC2-203 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 BICDL3P LncRNA Homo sapiens Breast Neoplasms BC tissues and cell lines Expression(highly expressed) qRT-PCR//Bioinformatics Analysis According to the qRT-PCR assay, the expression levels of LINC01133 and ZEB1-AS1 were decreased in luminal BC tissues and cell lines. On the other hand, ABHD11-AS1 was upregulated in the above-mentioned samples. The expression levels of LINC01133, ZEB1-AS1, and ABHD11-AS1 were not associated with any of the clinical features. Also, the results obtained from the bioinformatics analyses were consistent with qRT-PCR data. No 34446052 BICDL3P LncRNA Homo sapiens Pancreatic Neoplasms blood Expression[highly expressed] qRT-PCR After selection and validation, three characteristic plasma candidate lncRNAs, ABHD11-AS1, LINC00176 and SNHG11, were identified, and their levels were significantly higher in PC patients than in normal controls. No 31333792 BHLHE40-AS1-203 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 BFSP2-AS1 LncRNA Homo sapiens Adenocarcinoma of Lung TCGA(LUAD cancer and normal samples) Regulation Survival Analysis Herein, we identified an eight-lncRNA signature (PR-lncRNA signature, NPSR1-AS1, SATB2-AS1, LINC01090, FGF12-AS2, AC005256.1, MAFA-AS1, BFSP2-AS1, and CPC5-AS1), which contributes to predicting LUAD patient's prognosis risk and survival outcomes. Of them, NPSR1-AS1, SATB2-AS1, FGF12-AS2, and AC005256.1 could be acted as the poor prognosis markers, while LINC01090, MAFA-AS1, BFSP2-AS1, and CPC5-AS1 were treated as the protective factors for survival in LUAD patients. No 34550610 BEST3 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 BCYRN1 LncRNA Homo sapiens Stomach Neoplasms GC tissues,cells lines( BGC-823,AGS,GES-1 ) Interaction[miR-204-5p] CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay We observed that BCYRN1 expression was obviously higher in GC tissues than in the adjacent normal tissues in TCGA database (P<0.001, Figure 1A). The result revealed that BCYRN1 was notably overexpressed in GC cell lines compared with gastric epithelium cell line .we confirmed that Expression[down-expression]-regulation of BCYRN1 inhibited GC cell proliferation, migration and invasion through directly Expression[Expression[up-expression]-expression]-regulated miR-204-5p expression. To further explore the clinical value of BCYRN1 in GC patients, we estimated the association between BCYRN1 expression and clinicopathological characteristics through Chi square test. First, all GC cases are divided into low BCYRN1 expression groExpression[Expression[up-expression]-expression] and high BCYRN1 expression groExpression[Expression[up-expression]-expression] based on the median value of BCYRN1 expression. As shown in Table 1, BCYRN1 expression was closely correlated with tumor depth (P=0.002), lymph node metastasis (P=0.001) and clinical stage (P<0.001) in patients with GC. However, BCYRN1 expression in GC patients had no association with gender (P=0.0324), age (P=0.774) and distant metastasis (P=0.138). No 31652309 BCYRN1 LncRNA Homo sapiens Alzheimer Disease AD patients Expression(highly expressed) qRT-PCR//RNA-seq We found that the NEAT1 and BC200 levels in the plasma of the AD patients were significantly higher compared with the control group (P=0.0021, p= 0.02, respectively).Besides, plasma level of BC200 discriminated the pre-clinical subjects from healthy controls with 83 % sensitivity and 66 % specificity. Besides, plasma level of BC200 discriminated the pre-clinical subjects from healthy controls with 83 % sensitivity and 66 % specificity. No 35949493 BCYRN1 LncRNA Homo sapiens Asthma serum samples Regulation qRT-PCR the expression of LncRNA BCYRN1 was positively correlated with the expression of TNF-α and IgE (r=0.712, 0.748, all P<0.001). No 35818246 BCYRN1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung NSCLC tissues and cells regulation[miR-149/PKM2 axis] CCK8//qRT-PCR//Luciferase Report Assay High BCYRN1 expression was observed in NSCLC tissues and cells compared with the corresponding controls. The present study suggested that BCYRN1 was involved in cell glycolysis, proliferation and invasion during NSCLC via regulating miR‑149 and PKM2. No 32016455 BCYRN1 LncRNA Homo sapiens Parathyroid Neoplasms serum Expression(highly expressed) qRT-PCR Our results show that BC200 counts are higher in serum from patients harboring PCa (n=4) compared to patients with parathyroid adenoma (PAd; n=27). Then, we found that BC200 is overexpressed in metastatic PCas (n=4) compared to non-metastatic ones (n=9). No 35586620 BCL3 CircRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 BCL2L12 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 BCL11A-223 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 BCAR4 LncRNA Homo sapiens Breast Neoplasms 478 cases are all new breast cancer patients Mutation [rs4561483, rs11649623 and rs13334967] qRT-PCR//Genotyping We found that BCAR4 rs13334967 is associated with lower breast cancer risk both in codominant model (AT vs AA, OR 0.632, 95% CI 0.429–0.931, TT vs AA, OR 0.731, 95% CI 0.511–0.990) and dominant model (AT + TT vs AA, OR 0.798, 95% CI 0.571–0.970). The further results of qRT-PCR displayed that carriers with rs13334967 AT, TT genotype have lower BCAR4 mRNA expression compared with AA genotype. No 33113070 BCAR4 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues Expression[lower expressed] qRT-PCR The expression level of lncRNA NEAT1, H19, MALAT1, HOTAIR, DANCR, UCA1, and BCAR4 were significantly decreased, compared with that in adjacent noncancerous tissues (all P <.05). The expression level of lncRNA GAS5 was statistically significantly increased (P <.05). For the quantitative polymerase chain reaction (qPCR) assay, 8 kinds of lncRNAs were detected as a result of the GeXP assay. No 30423146 BCAR4 LncRNA Homo sapiens Prostatic Neoplasms PC tissues Expression(highly expressed) qRT-PCR//Bioinformatics Analysis//Western Blot BCAR4 and Beclin-1 were both upregulated in PC and were positively correlated.BCAR4 directly activated Beclin-1 at transcriptional level, which subsequently increased the ratio of LC3 II to LC3I to augment PC cell autophagy. Beclin-1 did not control levels of BCAR4. Mechanically, BCAR4 and Beclin-1 shared several targeting microRNAs, among which miR-15 and miR-146 appeared to be the mediators of the effects of BACR4 on Beclin-1. No 34984190 BCAP31P1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 BC130595 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)55) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 BC080653 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)58) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 bc043564 LncRNA Homo sapiens brain glioma brain glioma tissues Expression[lower expressed] qRT-PCR Consistent with the microarray data, qPCR confirmed differential expression of these 6 lncRNAs (ak125809, ak098473, uc002ehu.1, bc043564, NR_027322, and uc003qmb.2) between tumor and peritumoral tissue. No 32051722 BC041954 LncRNA Homo sapiens Ovarian Neoplasms 103 OC tissues Expression(highly expressed) qRT-PCR BC041954 expression was increased in 103 OC tissues as compared with that in NT tissues. Upregulated BC041954 expression was significantly associated with the International Federation of Gynecology and Obstetrics stage and distant metastasis. Kaplan-Meier analysis demonstrated that patients with high BC041954 expression had lower overall survival (OS). No 35619633 BC041938 LncRNA Homo sapiens Atrial Fibrillation Right atrial appendage tissue Expression[lower expressed] qRT-PCR//Microarray "The top ten up/down-regulated lncRNAs in the AF group compared with the NSR group are listed in Table II." No 30402860 BC034684 LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[highly expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 BBOX1-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 BBOX1-AS1 LncRNA Homo sapiens lung non-small cell carcinoma NSCLC tissues and cells Interaction( miR-27a-5p/MELK/FAK signaling) In Vivo Experiment//IHC//ChIP//Western Blot//Bioinformatics Analysis//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay " BBOX1-AS1 was highly expressed in NSCLC tissues and cells. BBOX1-AS1 up-regulation was induced by transcription factor KLF5. BBOX1-AS1 deficiency resulted in an inhibition of cell proliferation, migration, invasion and EMT in vitro. Mechanistically, BBOX1-AS1 acted act as a competetive ""sponge"" of miR-27a-5p to promote maternal embryonic leucine zipper kinase (MELK) expression and activate FAK signaling. miR-27a-5p was confirmed as a tumor suppressor in NSCLC. Moreover, BBOX1-AS1-induced increase of cell proliferation, migration, invasion and EMT was greatly reversed due to the overexpression of miR-27a-5p. In addition, the suppressive effect of NSCLC progression owing to BBOX1-AS1 depletion was abated by the up-regulation of MELK. " High BBOX1-AS1 expression was associated with worse clinical parameters and poor prognosis. Also, knockdown of BBOX1-AS1 suppressed NSCLC xenograft tumor growth in mice in vivo. No 33931086 BARX1-DT LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [highly expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 BARD1 LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-20A) Expression[no-differently] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD14 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 BANCR LncRNA Homo sapiens Breast Neoplasms BC cell lines and tissues Expression[highly expressed] qRT-PCR//MTT The present study revealed that BANCR was overexpressed in BC cell lines and tissues, and could promote the clinical progression of disease, including increases in tumor size, lymph node metastasis and Tumor-Node-Metastasis stage. The present study revealed that BANCR was overexpressed in BC cell lines and tissues, and could promote the clinical progression of disease, including increases in tumor size, lymph node metastasis and Tumor-Node-Metastasis stage.Furthermore, high BANCR expression was demonstrated to be associated with poor overall survival rates and early recurrence of BC in patients. No 29805676 CARLo-7-A LncRNA Homo sapiens Urinary Bladder Neoplasms bladder cancer tissues Regualtion[up-regulated] qRT-PCR In the current study, we report CARLo-7 as the only bladder cancer-specific lncRNA from the CARLos cluster. The expression of this lncRNA correlates with bladder cancer grade. We propose that CARLo-7 has an oncogenic potential and might be regulator of cell proliferation. No 30883984 CARMN LncRNA Homo sapiens Endometrial Neoplasms Serum and tissue samples Expression(lower expressed) RNA-seq At the same time, lncRNA sequencing results showed that when endometrial atypical hyperplasia continued to change, including LINC00511, PVT1, and IQCH-AS1 (downregulated), and only changed significantly in the endometrial dysplasia group, including MALAT1, CARMN (downregulated) and LINC00648, BISPR, LINC01534, and LINC00930 (upregulated). No 36510632 CDKN2B-AS1 LncRNA Homo sapiens Psoriasis psoriasis tissues Mutation[rs4977574 ] Genotyping The C allele of rs1333048 SNP was significantly more prevalent among cases compared with controls (OR (95% CI) = 1.56 (1.23-1.97), adjusted P value = 8.31E-4). The A allele of the rs4977574 had a protective effect against psoriasis (OR (95% CI) = 0.63 (0.49-0.81), adjusted P value = 0.001). No 31812071 CCNDBP1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CCN4 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CCL15-CCL14 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CCHE1 LncRNA Homo sapiens Colorectal Neoplasms CC tissues and adjacent normal tissues Interaction[ERK/COX-2 pathway] qRT-PCR Our data revealed that lncRNA-CCHE1 expression levels were significantly upregulated in colon cancer specimens compared with the matched adjacent normal colon tissues (p < 0.0001). These findings signify that lncRNA-CCHE1 is a key oncogene possibly involved in CRC development and progression by modulating ERK/COX-2 pathway and cell proliferation activity. No 30484108 CCHE1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancerous tissues Expression[highly expressed] qRT-PCR Our findings showed that the lncRNA-CCHE1 was significantly over-expressed in cervical cancerous tissues compared to non-cancerous tissue In extension, lncRNA-CCHE1 expression variation was correlated with the histological type (P = 0.001), tumor size (P = 0.001) and FIGO stage (P = 0.001). No 31364021 CCEPR LncRNA Homo sapiens Osteosarcoma osteosarcoma tissue Expression[highly expressed] qRT-PCR In this study, we found CCEPR expression was elevated in osteosarcoma tissue specimens and cell lines compared with adjacent normal tissue specimens and osteoblast cell line, respectively.The in vitro study indicated that CCEPR positively regulated proliferating cell nuclear antigen (PCNA) expression in osteosarcoma cells and silencing of CCEPR inhibited osteosarcoma cell proliferation through decreasing PCNA expression. In conclusion, CCEPR is a potential prognostic predictor and functions as oncogenic long non-coding RNA (lncRNA) to regulate cell proliferation via PCNA in osteosarcoma. Meanwhile, osteosarcoma patients with advanced stage or tumor size greater than 8 cm had higher expression of CCEPR than patients with early stage or tumor size less than or equal to 8 cm, respectively.Survival analysis suggested that osteosarcoma patients with high CCEPR expression had a worse overall survival rate than those with low CCEPR expression. No 30861164 CCDST LncRNA Homo sapiens Uterine Cervical Neoplasms CC tissues Interaction[DHX9-lncRNA-MDM2 ] RNA Pull-Down//IHC//Western Blot//CCK8//qRT-PCR//RIP//Microarray//Colony Formation Assay DHX9 is upregulated in CC tissue, and promotes CC cell motility and angiogenesis. Our results have revealed a novel mechanism by which high-risk HPVs promote motility and angiogenesis of CC by inhibiting expression of lnc-CCDST to disrupt MDM2 and DHX9 interaction, and DHX9 degradation, and identified a potential therapeutic target for CC. No 30518908 CCDC88A CircRNA Homo sapiens Retinoblastoma retinoblastoma tissues Expression[differently expression] qRT-PCR//RNA-seq The top 20 differentially-expressed circRNAs are listed in Table 2. We further validated the four Expression[down-expression]regulated circRNAs in recurrent RB samples and found a significant lower expression of MKLN1-hsa_circ_0082415 and TTLL1-has_circ_0116692 in recurrent RB samples compared to primary RB samples. (SExpression[Expression[up-expression]-expression]plementary Fig. 1). No 30917906 CCDC80 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CCDC80 LncRNA Homo sapiens gastric adenocarcinoma 90 paired GC and matched adjacent normal tissue specimens Expression [highly expressed] qRT-PCR LINC01279 was highly expressed in gastric cancer tissues and serum of gastric cancer patients (P < 0.05). The expression level of lncRNA 01279 was closely related to vascular invasion, nerve invasion, T-stage, lymph node metastasis, and advanced clinical-stage of gastric cancer (P < 0.05). There was a significant negative correlation between the expression of LINC01279 and the overall survival of gastric-cancer patients (P < 0.05). No 34507839 CCDC66 CircRNA Homo sapiens Carcinoma, Renal Cell cell lines Expression[highly expressed] qRT-PCR The results showed that cir-CCDC66 was upregulated not only in renal carcinoma cancer cancer cell lines but also in cancer stem cell spheres. No 31994979 CCDC26 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[lower expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 CCDC194-201 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[highly expressed] qRT-PCR//Microarray To explore the role of lncRNAs in OSCC, we performed a genome-wide analysis of lncRNA and mRNA expression in OSCC and normal tissues. The results of the microarray assays showed that 2,294 differentially expressed lncRNAs (accounting for 2.9% of all detectable lncRNAs) and 1,938 differentially expressed mRNAs (accounting for 10.3% of all detectable mRNAs) were identified. Furthermore, 933 lncRNAs and 891 mRNAs were upregulated and 1,361 lncRNAs and 1,047 mRNAs were downregulated. The most upregulated lncRNA and mRNA were MANSC4-8:1 (FC=201.36) and MMP7 (FC=2167.59), respectively. The most downregulated lncRNA and mRNA were NR_117092 (FC=418.62) and IL36A (FC=257.61), respectively. The top 20 dysregulated lncRNAs and mRNAs are summarized in Tables III and ​andIV,IV, respectively. No 30431131 CCDC18-AS1 LncRNA Homo sapiens Breast Neoplasms GSE71053 dataset Expression(highly expressed) qRT-PCR//Bioinformatics Analysis CCDC18-AS1, LINC01343, and SFN were expressed higher in BC than in the control (normal paired) tissues based on qRT-PCR data. The investigation of clinicopathological parameters showed that SFN was highly expressed in tumor size of <5 cm and in nonmenopausal ages, while CCDC18-AS1 and LINC01343 indicated a high expression in stages II-III and III of BC, respectively. The overall survival analysis displayed high and low survival in patients with high expression of SFN and CCDC18-AS1, respectively. The ROC curve analysis disclosed that SFN, CCDC18-AS1, and LINC01343 might be suggested as potential biological markers in BC patients. No 36160032 CCDC144NL-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CCDC144CP LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CCDC144A LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CCDC12 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CCAT2 LncRNA Homo sapiens Lung Neoplasms 438 patients with lung cancer and 456 healthy controls in the Han population from southern China Mutation(rs6983267 ) Genotyping The rs6983267 G allele, compared with the T allele, increased the risk of lung cancer [OR=1.29, 95% CI (1.07-1.57), P=0.007], and rs6983267 was identified as a risk factor for lung cancer [OR=1.28, 95% CI (1.06-1.55), P=0.003] in the additive model. No 33542645 CCAT2 LncRNA Homo sapiens Colorectal Neoplasms CRC tissues,blood Expression[highly expressed] qRT-PCR The levels of CCAT2 expression were significantly over-expressed in tumor tissues (p < 0.05) compared to adjacent non-tumorous tissues. Moreover, the serum levels of CCAT2 expression were significantly over-expressed in CRC patients (p < 0.05) compared to those in healthy subjects Higher CCAT2 expression was associated with advanced CRC patients. No 30877883 CCAT2 LncRNA Homo sapiens Carcinoma, Hepatocellular liver tissues Expression[highly expressed] qRT-PCR CCAT2 expression levels were significantly increased in HCC tissues compared to that in their normal counterparts CCAT2 expression was significantly correlated with vascular invasion (P = .001), histopathologic grading (P = .001), distant metastasis (P = .002) and TNM stage (P = .018). A Kaplan-Meier survival curve showed that the overall survival rate of HCC patients in high CCAT2 expression group markedly decreased as compared with that of low CCAT2 expression group (P = .016). No 31626095 CCAT2 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Mutation[ rs6983267 ] Genotyping We found that carriers of rs6983267 GG in CCAT2 were more susceptible to HCC, with the odds ratio (OR) and adjusted odds ratio (AOR) being 1.532 (95% CI, 1.103-2.129; p = 0.011) and 1.627 (95% CI, 1.120-2.265; p = 0.033), respectively. No 31398859 CCAT2 LncRNA Homo sapiens Uterine Cervical Neoplasms serum Expression(highly expressed) qRT-PCR CCAT2 expression in recurrent/metastatic CC was significantly higher compared with primary CC (P < 0.0001) or operated CC (P < 0.0001) and during follow-up, CCAT2 expression was increased before surgery and decreased significantly after surgery (P < 0.0001). Furthermore, the overall survival rate of CC patients with high CCAT2 expression group markedly decreased as compared with that of low CCAT2 expression group (P = 0.026). No 35115025 CCAT2 LncRNA Homo sapiens Glioma Glioma tissues and cells Expression[highly expressed] qRT-PCR Glioma tissues and cells were monitored with higher CCAT2 expression and lower miR-424 expression than adjacent normal tissues and NHA cell line (P<0.05). No 32110042 CCAT2 LncRNA Homo sapiens Multiple Myeloma serum and bone marrow Expression[highly expressed] qRT-PCR In our study, the expression of lncRNA CCAT2 is upregulated in the serum and bone marrow of MM patients by using quantitative real-time polymerase chain reaction (qRT-PCR). No 32591878 CCAT2 LncRNA Homo sapiens Sepsis Southern Chinese Population Mutation(Rs6983267 ) Genotyping//Bioinformatics Analysis We found that the CCAT2 gene polymorphism rs6983267 T > G may be associated with an increased risk of pediatric sepsis in southern China. No 34377001 CCAT2 LncRNA Homo sapiens Abortion, Habitual blood Mutation[rs6983267G ] qRT-PCR//Genotyping We genotyped two lncRNA CCAT2 polymorphisms (rs6983267 and rs3843549) in 248 patients with recurrent miscarriage and 392 controls through a TaqMan real-time polymerase chain reaction assay, and the strength of each association was evaluated via 95% confidence intervals (CIs) and odds ratios (ORs). Our results showed that the rs6983267 G allele in lncRNA CCAT2 was associated with decreased susceptibility to recurrent miscarriage (TG vs. TT: adjusted OR = 0.603; 95% CI = 0.420-0.866; p = 0.0062; GG/TG vs. TT: adjusted OR = 0.620; 95% CI = 0.441-0.873; p = 0.0061). The combined analysis of the two protective polymorphisms (rs3843549 AA and rs6983267 TG/GG) revealed that individuals with two unfavorable alleles exhibited a lower risk of recurrent miscarriage than those with no or only one unfavorable allele (adjusted OR = 0.531; 95% CI = 0.382-0.739). Moreover, the decreased risk associated with the two protective alleles was most obvious in women aged less than 35 years (OR = 0.551; 95% CI = 0.378-0.8803; p = 0.0019) and in women with two to three miscarriages (adjusted OR = 0.466; 95% CI = 0.318-0.683; p < 0.0001). In conclusion, our study indicates that the rs6983267G allele might contribute to a decreased risk of recurrent miscarriage in the South Chinese population. No 30982978 CCAT2 LncRNA Homo sapiens Leukemia, Myelogenous, Chronic, BCR-ABL Positive peripheral blood mononuclear cells Expression(highly expressed) qRT-PCR Our results reported for the first time the upregulated expression of CCAT2 in CML patients as compared with controls (P < 0.001). We demonstrated significant association between CCAT2 expression and therapy response at 3 months, and at 6 months (P = 0.004, and P = 0.005; respectively). Moreover, CCAT2 expression was significantly associated with spleen size (P = 0.006) and EUTOS sore (P = 0.030). LncRNA CCAT2 is highly expressed in the peripheral blood of CML patients, and the enhanced expression at diagnosis is linked to imatinib resistance. CCAT2 is expected to become a reliable molecular marker for predicting imatinib response in chronic phase CML patients. We demonstrated significant association between CCAT2 expression and therapy response at 3 months, and at 6 months (P = 0.004, and P = 0.005; respectively). Moreover, CCAT2 expression was significantly associated with spleen size (P = 0.006) and EUTOS sore (P = 0.030). LncRNA CCAT2 is highly expressed in the peripheral blood of CML patients, and the enhanced expression at diagnosis is linked to imatinib resistance. No 35367722 CCAT1 LncRNA Homo sapiens Stomach Neoplasms Serum samples of 27 healthy control subjects, 26 patients with chronic gastritis, 30 patients with atypical hyperplasia and 113 patients with GC Expression [highly expressed] qRT-PCR//Western Blot The results revealed that serum EV lncRNA CCAT1 levels in patients with GC were significantly higher compared with those in healthy controls, patients with chronic gastritis or atypical hyperplasia (all P<0.05). Additionally, EV lncRNA CCAT1 expression levels were significantly different among various groups based on the depth of invasion, distant metastasis and the Tumor-Node-Metastasis stage.  No 33868485 CCAT1 LncRNA Homo sapiens Carcinoma, Non-Small-Cell Lung blood Expression[highly expressed] qRT-PCR CCAT1 and SOX2OT were shown to be detectable in the cellular fraction of peripheral human blood, showing serum levels of CCAT1 and SOX2OT were significantly increased of cancer patients as compared to cancer-free controls. No 31933793 CCN6 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CCNH-205 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CCAT1 LncRNA Homo sapiens Colorectal Neoplasms blood Expression[highly expressed] qRT-PCR Briefly, after plasma separation and total RNA extraction, RNAs were reversely transcribed to complementary DNA followed by amplification using a quantitative real-time polymerase chain reaction technique for lncRNA expression analysis. The results showed that the expression levels of lnc-ATB (p < 0.001) and CCAT1 (p = 0.024), but not OCC-1 (p = 0.25), were significantly upregulated in the CRC compared with the healthy group. No 31093977 CCNJL LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CDKN2B-AS1 LncRNA Homo sapiens Ischemic Stroke Chinese Han population Mutation(rs4977574) Genotyping Our findings indicated G allele of lncRNA ANRIL rs4977574 could increase the risk of IS, and the variant may be associated with susceptibility to LAA-IS in Chinese Han population. No 33725991 CDKN2B-AS1 LncRNA Homo sapiens Periodontitis blood Expression[lower expressed] qRT-PCR Expression of ANRIL was significantly lower in peripheral blood of patients compared with controls (Posterior Beta RE = -1.734, P value = 0.035). No 32346660 CDKN2B-AS1 LncRNA Homo sapiens Asthma blood Regulation[ANRIL/miR-125a axis ] ELISA//qPCR LncRNA ANRIL/miR-125a axis was upregulated in BA-E patients compared with BA-R patients and controls.LncRNA ANRIL/miR-125a is potentially indicative of disease exacerbation, exacerbation severity, and inflammation for bronchial asthma, while these findings are preliminary and need further confirmation. No 31821602 CDKN2B-AS1 LncRNA Homo sapiens beta-Thalassemia blood Interaction[CDH60 ] qRT-PCR Significant higher expression levels of the studied lncRNAs in β-thal patients compared to the controls (all P values < 0.001) were identified. No 30665334 CDKN2B-AS1 LncRNA Homo sapiens Diabetic Nephropathies DKD patients Expression(highly expressed) qRT-PCR The expression of ANRIL was significantly up-regulated in DKD patients (microalbuminuria, macroalbuminuria and renal dysfunction groups) than that in healthy control group. ANRIL was also over-expressed in macroalbuminuria and renal dysfunction groups in comparison with normalbuminuria group. ANRIL expression was positively correlated with Scr, BUN, CysC, urine β2-MG and urine α1-MG; while negatively correlated with eGFR in DKD patients. In addition, ANRIL was the risk factor for DKD with OR value of 1.681. The AUC of ANRIL in identifying DKD was 0.922, and the sensitivity and specificity of DKD diagnosis were 83.3% and 90.5%, respectively. No 36129598 CDKN2B-AS1 LncRNA Homo sapiens Coronary Disease patients with coronary heart disease Expression[lower expressed] qRT-PCR The expression of LncRNA-ANRIL in patients with coronary heart disease was lower than that of normal subjects (p<0.05), and the expression levels of Gensini score, LDH, CK-MB, CK, and BNP gradually increased with the increased number of their diseased vessels (p<0.05). No 31957852 CDKN2B-AS1 LncRNA Homo sapiens Coronary Disease 112 patients with CHD Expression(lower expressed) Bioinformatics Analysis The expression level of serum ANRIL in preSG was significantly lower than those in CG and postSG (P < 0.05). According to the survival curves, the 3-year overall survival rate in the high-ANRIL expression group was significantly lower than that in the low-expression group (P < 0.05). No 34901274 CDKN2B-AS1 LncRNA Homo sapiens Ischemic Stroke serum Mutation(G varian) qRT-PCR//Genotyping serum MALAT1 was downregulated, while serum ANRIL was overexpressed in CIS patients, relative to controls. MALAT1 downregulation discriminated CIS patients from controls by receiver-operating-characteristic analysis. Moreover, serum ANRIL denoted good diagnostic accuracy. MALAT1 rs619586 AA and rs3200401 CT, TT were associated with increased CIS risk, whereas ANRIL rs10965215 GG was found to be protective. The studied ANRIL rs10738605 polymorphism was not associated with CIS susceptibility. Notably, the G variant of MALAT1 rs619586 demonstrated a higher serum MALAT1 expression level. Multivariate logistic regression analysis revealed serum MALAT1 as well as MALAT1 rs3200401 CT + TT as independent predictors of CIS. Additionally, a negative association was found between the serum MALAT1 level and the National Institutes of Health Stroke Scale score. In conclusion, MALAT1 rs619586 and rs3200401 and ANRIL rs10965215 are novel prospective noninvasive diagnostic biomarkers for CIS predisposition. serum ANRIL denoted good diagnostic accuracy.Additionally, a negative association was found between the serum MALAT1 level and the National Institutes of Health Stroke Scale score. No 33818067 CDKN2B-AS1 LncRNA Homo sapiens Ichthyosis Vulgaris northern China Mutation(rs3217992, rs2518723, rs1333048, rs10757278, rs10757278 ) Other The C allele of rs3217992 and the T allele of rs2518723 were more prevalent in the case group than in the control group. The haplotypes, CTATAA, CCCCGG, and CTCCGG, were associated with risk of psoriasis, while the TCCCGG, TCATAA and CCATAA haplotypes were protective against psoriasis. Based on subgroup analysis, patients with the CT genotype at the rs3217992 and rs2518723 loci had a higher probability of a family history of psoriasis, and patients with the AA genotype had a higher mean age in the rs1333048 and rs10757278 groups, while those with the TT genotype had a higher mean age in the rs1333045 group. No 35866908 CDKN2B-AS1 LncRNA Homo sapiens steroid-induced glaucoma TM tissue of SIG mice Interaction(p15) Western Blot//qRT-PCR//Luciferase Report Assay//Microarray//Cell Cycle Assay//IHC//IF Especially, we established the transcriptome landscape in the TM tissue of SIG mice via microarray screening and identified ANRIL as the most differentially expressed long non-coding RNA, with a 5.4-fold change.The expression level of ANRIL was closely related to ocular manifestations (IOP elevation, cup/disc ratio, and retinal nerve fiber layer thickness). Furthermore, p15, the molecular target of ANRIL, was significantly upregulated in SIG and was correlated with ocular manifestations in an opposite direction to ANRIL. No 35563774 CDKN2B-AS1 LncRNA Homo sapiens Intracranial Aneurysm Asians Mutation(rs10757272 ) Bioinformatics Analysis The pooled results indicated that the rs10757272 polymorphism is significantly associated with the risk of intracranial aneurysms in all genetic models (homozygous model, odds ratio (OR) = 1.48, 95% confidence interval (CI) = 1.28-1.71, Pheterogeneity = 0.11, I2 = 50.9; heterozygous model, OR = 1.26, 95% CI = 1.09-1.46, Pheterogeneity = 0.15, I2 = 42.8; dominant model, OR = 1.37, 95% CI = 1.19-1.57, Pheterogeneity = 0.12, I2 = 48.1; and recessive model, OR = 1.23, 95% CI = 1.13-1.34, Pheterogeneity = 0.24, I2 = 28.8). Subgroup analyses showed consistent results. No 36512102 CDKN2BAS1 LncRNA Homo sapiens Diabetes Mellitus peripheral blood mononuclear cells Expression[highly expressed] qRT-PCR Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects. No 30139387 CDKN2B/CDKN2B-AS1 LncRNA Homo sapiens Glaucoma four SNPs (rs2157719, rs3217992, rs4977756, rs1063192) of aforementioned genes Mutation(rs3217992, rs2157719) Meta-analysis//Genotyping Two SNPs, rs3217992 and rs2157719 were found to be significantly associated with the disease. The frequency of 'T' allele of rs3217992 was significantly lower in cases (POAG/PACG) [p = 0.045; OR = 0.80(CI = 0.65-0.99) and p = 0.024; OR = 0.73(CI = 0.55-0.96)], respectively than in controls. Genetic model analysis revealed that TT + CT genotype confers 0.73-fold protection against POAG [p = 0.047; OR = 0.73(CI = 0.54-0.99)] and trend assumed additive model gives 0.53 times higher protection against PACG progression. However the association of rs3217992 with POAG and PACG did not remain significant after Bonferroni correction. For rs2157719, the 'C' allele was found to be less prevalent among cases (POAG/PACG) with respect to controls. Cochran Armitage trend test assuming additive model revealed 0.77 and 0.64-fold protection against POAG and PACG respectively. Bonferroni correction (pcorr = 0.003) was applied and the association of rs2157719 remained significant in PACG cases but not among POAG cases (p = 0.024). The 'CC' genotype also confers protection against primary glaucoma (POAG/PACG) among males and female subjects. The frequency rs1063192 and rs4977756 did not vary significantly among subjects, however the haplotype 'CATA' was found to be associated with increased glaucoma risk. An updated meta-analysis conducted on pooled studies on POAG cases and controls revealed significant association between rs1063192, rs2157719, rs4977756 and POAG except rs3217992. No 33397358 CDKN2A-DT LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissues Expression[highly expressed] qRT-PCR qPCR results indicated marked upregulation of CDKN2A-AS1, C7orf55, LINC00184, HEIH, and ZEB2 expression, whereas that of SNHG3, LINC00630, LOC100133669, APTR, LINC-PINT, and SEMA5A was downregulated in OC tissues as compared with levels in normal ovary tissues (Fig. ?(Fig.5b5b). No 31098301 CDKN2A-DT LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck 501 HNSCC tumor samples Regulation Bioinformatics Analysis The Prognostic Signature is based on 10 cuproptosis-related lncRNAs including AC090587.1, AC004943.2, TTN-AS1, AL162458.1, AC106820.5, AC012313.5, AL132800.1, WDFY3-AS2, CDKN2A-DT, and AL136419.3. The results of overall survival, risk score distribution, and survival status in the low-risk group were better than those in the high-risk group. In addition, all immune checkpoint genes involved were significantly different between the two risk groups (p < 0.05). The risk score was positively correlated with Eosinophils. M0 and M2 phenotype macrophages, mast cells activated, NK cells activated, and negatively related with B cells naive, mast cells resting, plasma cells, CD8T cells, T cells follicular helper, T cells regulatory (Tregs). No 35942287 CDK6-AS1 LncRNA Homo sapiens Stomach Neoplasms GC tissues and cells Regulation(CDK6) Bioinformatics Analysis CDK6-AS1, a long non-coding RNA cyclin-dependent kinase 6, may serve as a poor potential prognostic biomarker candidate in gastric cancer with a positive correlation with its target gene CDK6. The low CDK6-AS1 expression group showed more frequent mutated driver genes than the high expression group. Moreover, CDK6-AS1 is involved in a key oncogenic pathway of the cell cycle and RNA transcription. No 35571043 CDK6-AS1 LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 CDK5RAP1-211 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CDH19 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CDCA4P3 LncRNA Homo sapiens Leukemia, Myeloid, Acute Bone marrow Expression[highly expressed] qPCR//RNA-seq In further qPCR validation, lncRNA RP11-342M1.7 and lncRNA CDCA4P3 were upregulated, while lncRNA CES1P1, lncRNA AC008753.6 and lncRNA RP11-573G6.11 were downregulated in AML patients compared with controls. No 31356197 CDC25B LncRNA Homo sapiens Breast Neoplasms cell lines(MCF-7, MDA-MB-231, MDA-MB-436,MCF-18A) Expression[highly expressed] qRT-PCR MTOR, RAD51B, JUN, PELP1, IL6, TGFBR2, HEATR6, RAD51C and CDC25B showed high expression in breast cancer cell lines, but BRMS1, BARD1, KMD5B, HIF1A, BACH1, and MTA1 maintained a comparable gene expression level between normal and breast cancer cell lines. On the other hand, RAD51, PTK6, STAT1 and SMAD12 showed lower gene expression levels in cancer cell lines than the normal cell line. No 30953646 CDC14C LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 CD99-213 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 CD27-AS1 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical carcinoma tissues Expression[lower expressed] qRT-PCR//Microarray CACX is one of the most common cancer affecting women world-wide. Here, expression microarray analysis revealed 8 over-expressed transcribed pseudogenes (GBP1P1, HLA-DRB6, HLA-H, SLC6A10P, NAPSB, KRT16P2, PTTG3P and RNF126P1), down-regulated 7 lincRNAs (H19, MIR100HG, MEG3, DIO3OS, HOXA11-AS, CD27-AS1 and EPB41L4A-AS) and 6 snoRNAs (SNORD97, SNORD3A, SNORD3C, SNORD3D, SNORA12 and SCARNA9) as DEncGs (log2 fold-change ≥ ±1.0) in CACX. No 31229557 CD274 LncRNA Homo sapiens Uterine Cervical Neoplasms cervical cancer tissues Expression[highly expressed] CCK8//qRT-PCR//Microarray//Colony Formation Assay//Transwell Assay From our results, 23,530 lncRNAs exhibited differential expression, including 9639 upregulated and 13,881 downregulated lncRNAs. The 20 top-ranked differentially expressed lncRNAs are listed in Table 1. No 32922596 CCT7 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CCT5-212 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 CCT3-214 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(highly expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 CCNT2-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CCAT1 LncRNA Homo sapiens Lung Neoplasms 669 lung cancer patients and 697 healthy controls Interaction( Rs1948915 CT, rs1948915 CT/CC, rs7013433 and rs6983267) Genotyping There may be an association between lung adenocarcinoma and rs1948915 polymorphism in the Chinese northeast population, while rs7013433 and rs6983267 might have no association. There was no interaction between the three selected SNPs and smoking status. No 35650713 CCAT1 LncRNA Homo sapiens Colonic Neoplasms colon cancer tissues,cell lines Expression[highly expressed] CCK8//qRT-PCR//Flow Cytometry CCAT1 in colon cancer tissues was higher than that in noncancer tissues, and the levels of CCAT1 in HCT 116, SW1417, HT-29, and KM12 cell lines were higher than those in the human normal colon epithelial NCM460 cell line. No 31039730 CARMN LncRNA Homo sapiens Atherosclerosis plaque tissues Expression[lower expressed] qRT-PCR//Microarray Based on the magnitude of change, we listed the top 10 upregulated and downregulated lncRNAs and mRNAs in Table 1 and Table 2. No 31682178 CASC2 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[lower expressed] qRT-PCR CASC2 was downregulated in HCC/HCV patients, whereas TUG1 was overexpressed in relation to HCV and the control group, indicating their antagonistic effect. No 31301261 CASC2 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck OSCC tissues Expression[lower expressed] CCK8//qRT-PCR We found that CASC2 was significantly downregulated in OSCC patients than in healthy controls. Downregulation of CASC2 distinguished OSCC patients from healthy controls. Local recurrence was observed in 26 out of 122 patients and no distant recurrence was observed during follow-up. Compared with pretreatment levels, plasma levels of CASC2 were significantly increased in patients with local recurrence than in patients without recurrence. No 30467776 CASC2 LncRNA Homo sapiens Glioma Glioma tissues interaction[miR-21] qRT-PCR CASC2 expression was significantly downregulated in glioblastomas (p = 0.0003).Taken together, these observations suggest that CASC2 acts as a tumor suppressor and potentially as a competing endogenous RNA (ceRNA) for miR-21, plays important role in IDH1 wild type glioma pathogenesis and patients' outcomes. Gliomas with low CASC2 expression exhibited a high level of miR-21, which was highly associated with the higher glioma grade (p = 0.0001), IDH1 wild type gliomas (p < 0.0001), and poor patient survival (p < 0.001). No 33120918 CASC2 LncRNA Homo sapiens Diabetes Mellitus, Type 2 serum and renal tissue Expression[lower expressed] qRT-PCR Compared with healthy controls, expression of lncRNA CASC2 in serum and renal tissue was specifically downregulated in patients with type 2 diabetes combined with chronic renal failure but not in type 2 diabetic patients combined with other complications. No 30170791 CASC2 LncRNA Homo sapiens Sepsis sepsis patients Expression(lower expressed) qRT-PCR//ELISA LncRNA CASC2 was decreased in sepsis patients [median (interquartile range [IQR]): 0.473 (0.241-0.773)] by comparison to healthy controls [median (IQR): 1.019 (0.676-1.685)] (p < 0.001). In sepsis patients, lncRNA CASC2 was negatively correlated with Acute Physiology and Chronic Health Evaluation II (APACHE II) (p = 0.001), Sequential Organ Failure Assessment (SOFA) (p < 0.001), SOFA-respiratory system (p = 0.010), SOFA-coagulation (p = 0.020), SOFA-liver (p = 0.019), and SOFA-renal (p = 0.010) scores, but was not related to SOFA-nervous (p = 0.466) and SOFA-cardio vascular system (p = 0.059) scores. Simultaneously, Kaplan-Meier (KM) curve analysis also observed that lncRNA CASC2 was inversely related to accumulating mortality in sepsis patients (p = 0.003). While lncRNA CASC2 could independently predict lower mortality risk. No 35754113 CASC2 LncRNA Homo sapiens Diabetes Mellitus blood Interaction[Inhibiting JNK Pathway] qRT-PCR We found that serum level of CASC2 was significantly lower in diabetic nephropathy patients than in normal people, and serum level of CASC2 showed no significant correlations with age, gender, alcohol consumption and smoking habits, but was correlated with course of disease. CASC2 expression level decreased, while JNK1 phosphorylation level increased in mouse podocyte cells treated with high glucose. CASC2 overexpression inhibited apoptosis of podocyte cells and reduced phosphorylation level of JNK1. We conclude that long non-coding RNA CASC2 may improve diabetic nephropathy by inhibiting JNK pathway. No 29890555 CASC2 LncRNA Homo sapiens Stomatitis, Aphthous plasma Expression[highly expressed] qRT-PCR//ELISA In the present study, we found that lncRNA Cancer Susceptibility Gene 2 (CASC2), as well as pro-inflammatory factors interleukin 6 (IL-6) and interleukin 18 (IL-18), were upregulated in plasma of RAS patients compared with healthy participants. No 31937279 CASC2 LncRNA Homo sapiens Cholangiocarcinoma carcinoma tissue Expression(highly expressed) qRT-PCR Specifically,CASC2 had higher expression level in the carcinoma tissue than in the para-carcinoma tissue(t=1.262,P=0.025),whereas the expression of H19 showed an opposite trend(t=1.285,P=0.005).The expression levels of H19 were significantly lower in RBE(t=-10.244,P<0.001),QBC939(t=-10.476,P<0.001),HuH-28(t=-19.798,P<0.001),and HuCCT1(t=-16.193,P=0.004)cells than in the control group. The expression level of lncRNA CASC2 was correlated with pathological differentiation(χ 2=6.222,P=0.022)and lymph node metastasis(χ2=5.455,P=0.020),and that of lncRNA H19 with pathological differentiation(χ2=1.174,P=0.029)and tumor size(χ2=-0.507,P=0.037). No 35300768 CASC2 LncRNA Homo sapiens Pneumonia, Necrotizing 145 children with severe pneumonia. Expression(lower expressed) qRT-PCR The serum levels of CASC2 significantly decreased in children with severe pneumonia in contrast with healthy individuals and reached the lowest value in those with RF. Serum CASC2 can distinguish severe pneumonia and predicted the development of RF. Based on the 28-day survival data, cases with low CASC2 levels had a poor survival rate. CASC2 (hazard ratio [HR] = 0.068, 95% confidence interval [CI] = 0.016-0.292, P < 0.001) and age (HR = 2.806, 95% CI = 1.240-6.394, P < 0.001) were independent influence factor for the poor prognosis of children with severe pneumonia. No 35665444 CASC19-231 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CASC19-212 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CASC18 LncRNA Homo sapiens COVID-19 mild and severe COVID-19 patients Regulation Bioinformatics Analysis Interestingly we found six lncRNAs (TALAM1, DLEU2, and UICLM CASC18, SNHG20, and GNAS) involved in the protein-coding DEG-lncRNA network; which might be served as potential biomarkers for COVID-19 patients. No 34975833 CASC15-303 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [highly expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CASC15-236 LncRNA Homo sapiens Pterygium six patients with primary pterygium Expression [lower expressed] qRT-PCR//IHC//RNA-seq In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues.  No 33790949 CASC15 LncRNA Homo sapiens Breast Neoplasms 681 patients with BC and 680 unrelated controls Mutation(rs7740084, rs1928168, rs9393266) Genotyping "Our results suggested that the lncRNA CASC15 rs7740084 ""G/G"" genotype and rs1928168 ""T/C"" genotype significantly reduced BC risk in different genetic models (P = .045, P = .029, and P = .047, respectively). However, rs9393266 ""C/T"" and ""C/T-T/T"" genotypes were correlated with the risk of BC (P = .021 and P = .048). In addition, we also observed that rs1928168 was related to the risk of BC in patients with age > 50 years (P = .025), body mass index > 24 (P = .006), and tumor size (P = .035). For rs9393266, it was revealed that the ""C/T"" and ""C/T-T/T"" genotypes were related to BC risk in people with age ≤ 50 years (P = .005) and body mass index > 24 (P = .023)." No 33551326 CASC15 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CASC15 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck plasma Expression[highly expressed] qRT-PCR In the present study, we showed that plasma CASC15 was up-regulated in stage I and II oral squamous cell carcinoma patients than in oral ulcer patients and healthy controls, while no significant correlation was found between oral ulcer patients and healthy controls. No 31793142 CASC15 LncRNA Homo sapiens Leukemia, Myeloid, Acute BM cells Expression(lower expressed) Bioinformatics Analysis The expression level of CASC15 was significantly decreased in BM cells of AML patients compared with healthy donors (P<0.001). The expression of CASC15 is decreased in AML, and low CASC15 expression may predict adverse prognosis in AML patients with NPM1 mutations. The expression of CASC15 was high at the early stage of hematopoiesis, and reached a peak at the stage of multipotent progenitors differentiation, then decreased rapidly, and was at a range of low level fluctuations in the subsequent process. No 35680788 CASC15 LncRNA Homo sapiens Uterine Cervical Neoplasms Mutation[rs12212674 ] Genotyping "Our study suggested that rs12212674 (NC_000006.12:g.22086845T>A) ""A"" allele was significantly associated with an increased risk of cervical cancer (OR = 1.31, 95% CI = 1.01-1.69, p = .041). " No 32329235 CASC15 LncRNA Homo sapiens Neuroblastoma Neuroblastoma tissues Expression[Expression[highly expressed]-expression] ChIP-seq//RNA-seq Differential analysis revealed nine significantly differentially expressed (more than 2-fold change with corrected p-value) lncRNAs between tumor cells and matched MNCs. Of these, RFPL1S (p = 0.0001), PPP1R26-AS1 (p = 0.03), RP11-439E19.3 (p = 1.24 × 10–6), CASC15 (p = 1.6 × 10–7), AC004540.5 (p = 0.0002), and CTD-2881E23.2 (p = 1.6 × 10–9) were found to be significantly Expression[up-expression]regulated (Figure 1B), while USP3-AS1 (p = 1.78 × 10–6), CHRM3-AS2 (p = 0.003) and RP6-99M1.2 (p = 0.002) were significantly downregulated (Figure 1C). No 31920530 CASC15 LncRNA Homo sapiens COVID-19 COVID-19 patients Regulation Bioinformatics Analysis This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis. No 33520952 CASC11 LncRNA Homo sapiens Osteoporosis, Postmenopausal blood Interaction[TNF-α] qPCR//Western Blot We found that CASC11 and TNF-α were both upregulated in plasma of POP patients than in healthy controls. No 31571846 CASC11 LncRNA Homo sapiens Prostatic Neoplasms Mutation[rs9642880, rs16902359] Genotyping Three SNPs (rs9642880, rs16902359, and rs12680047) and 79 SNP-SNP pairs were significantly associated with prostate cancer risk. These two SNPs (rs16902359 and rs9642880) in CASC11 interacted frequently with other SNPs with 56 and 9 pairs, respectively. No 30914434 CASC11 LncRNA Homo sapiens Coronary Artery Disease plasma regulation[TGF-β1] qRT-PCR Plasma levels of lncRNA CASC11 were downregulated in patients with CAD, while plasma TGF-β1 levels were upregulated in patients with CAD, compared with healthy controls. LncRNA CASC11 is downregulated in CAD and inhibits TGF-β1. No 32223575 CASC11 LncRNA Homo sapiens ovarian squamous cell carcinoma blood Expression[highly expressed] qRT-PCR In the present study we showed that plasma CASC11 was upregulated in OSCC, and the upregulation of CASC11 distinguished OSCC patients from control group. No 31181314 CASC11 LncRNA Homo sapiens Coronary Disease 464 CHD patients and 510 healthy controls Mutation(rs9642880) Genotyping The study displayed the contribution of CASC8, CASC11, and PVT1 genetic polymorphisms to CHD predisposition, and these variants could serve as potential biomarkers of CHD susceptibility.CASC11 rs9642880 (OR = 1.49, P = 0.021) was a risk factor for increased CHD susceptibility in subjects over 60 years old, and PVT1 rs4410871 was a protective factor for CHD susceptibility in males (OR = 0.67, P = 0.015) and smokers (OR = 0.62, P = 0.047). No 34001726 CARS1-AS1-204 LncRNA Homo sapiens Osteoarthritis Synovial exosomes of OA patients Expression [lower expressed] Flow Cytometry//qRT-PCR//Luciferase Report Assay//Western Blot There were 52 mRNAs, 196 lncRNAs and 98 circRNAs differentially expressed in synovial exosomes between osteoarthritis synovial and the control group. No 34780784 CARMN LncRNA Homo sapiens Breast Neoplasms BC tissues Expression[lower expressed] qRT-PCR//RNA-seq The expression levels of the top 10 upregulated and 10 downregulated lncRNAs are listed in Table 6. No 30981459 CARMN LncRNA Homo sapiens Carcinoma, Hepatocellular TCGA Interaction(miR-192-5p/LOXL2 Axis) qRT-PCR CARMN was considered to be the potential upstream lncRNA for the hsa-miR-192-5p/LOXL2 axis in HCC. Furthermore, the level LOXL2 was markedly positively associated with tumor immune cell infiltration and immune checkpoint expression in HCC. No 36254230 CASC2 LncRNA Homo sapiens Carcinoma, Hepatocellular HCC tissues and cells Expression[lower expressed] qRT-PCR The results demonstrated that CASC2 expression was significantly reduced in HCC tissues and cells No 31633393 CASC2 LncRNA Homo sapiens Osteoarthritis plasma regulation[MiR93-5p] qRT-PCR//Luciferase Report Assay In OA patients, miR-93-5p was downregulated, while CASC2 was upregulated, and they were inversely correlated. MiR-93-5p was downregulated in OA may inhibit LPS-induced chondrocyte apoptosis by targeting lncRNA CASC2. No 31931772 CCAT1 LncRNA Homo sapiens Ovarian Neoplasms 54 ovarian cancer samples Interaction(miR-203) Bioinformatics Analysis Real-time PCR on 54 ovarian cancer samples confirmed the high expression levels of CCAT1 and SNHG14 (logFC>1.5, p<0.05). The activating effect of CCAT1 and SNHG14 on the expression of these genes can be mediated by miR-203 and miR-124. No 35501644 CASC2 LncRNA Homo sapiens Breast Neoplasms a cohort of Iranian breast cancer patients Expression(lower expressed) Other Expression levels of TP53, MEG3, CASC2 and PANDA were significantly lower in tumoral samples compared with non-tumoral samples (Posterior mean differences = -4.26, -1.66, -5.98 and -3.13, respectively; P values < 0.0001).Expression of CASC2 was higher in Her2 1+ cases compared with Her2 negative cases (Beta = 1.85, P value = 0.037). Expression levels of MEG3 and TP53 were lower in grade 2 samples compared with grade 1 (Beta = -1.86, P value = 0.006 and Beta = -2.24, P value = 0.003, respectively). No 35034894 CCAT1 LncRNA Homo sapiens Ovarian Neoplasms ovarian cancer tissue Interaction( miR-1290) CCK8//qRT-PCR//Wound Healing Assay qRT-PCR showed that lncRNA CCAT1 was highly expressed in ovarian cancer tissue, compared with adjacent tissue. We also found that lncRNA CCAT1 could sponge miR-1290 in ovarian cancer. Moreover, we found that the expression of lncRNA CCAT1 was closely related to prognosis, tumor size, and lymph node metastasis. No 29424889 CCAT1 LncRNA Homo sapiens Leukemia, Myeloid, Acute blood Expression[highly expressed] qRT-PCR We investigated the expression levels of LncRNAs in 70 patients; 30 with t(8;21) positive AML and 40 with t(8;21) negative AML, We found that CCAT1 and PVT1 are expressed in higher levels in t(8;21) positive -AML by 5.3 folds compared to t(8;21) negative group; the expression values were significantly associated with high-risk clinical criteria; moreover, they are associated with lower overall survival (OS) rate and leukemia-free survival (LFS), however we didn't find a statistically significant cut-off value of LncRNAs using the Cox regression analysis for Lnc_PVT1 except with LFS, we conclude that high expression levels of CCAT1 and PVT1 are associated with poor prognosis while being poor prognostic biomarkers in t(8;21) associated AML. We investigated the expression levels of LncRNAs in 70 patients; 30 with t(8;21) positive AML and 40 with t(8;21) negative AML, We found that CCAT1 and PVT1 are expressed in higher levels in t(8;21) positive -AML by 5.3 folds compared to t(8;21) negative group; the expression values were significantly associated with high-risk clinical criteria; moreover, they are associated with lower overall survival (OS) rate and leukemia-free survival (LFS), however we didn't find a statistically significant cut-off value of LncRNAs using the Cox regression analysis for Lnc_PVT1 except with LFS, we conclude that high expression levels of CCAT1 and PVT1 are associated with poor prognosis while being poor prognostic biomarkers in t(8;21) associated AML. No 30943439 CCAT1 LncRNA Homo sapiens Multiple Myeloma MM tissues Expression[highly expressed] qRT-PCR//RNA-seq The DE analysis results of 14 known lncRNAs and 10 novel lncRNAs are shown in Tables 1 and ​and2,2, which were verified by Q-PCR (Tables 3 and ​and4).4). The Q-PCR results were consistent with the sequencing results (Figs. 7 and ​and8,8, respectively). No 31619233 CCAT1 LncRNA Homo sapiens Pre-Eclampsia Egyptian patients Expression(highly expressed) qRT-PCR Expression levels of CCAT1 and CDK4 differed significantly between the study groups.preeclamptic patients having the highest level of CCAT1in comparison with control group, However, preeclamptic patients having lower level of CDK4 than controls. Expression levels of CCAT1 and CDK4 differed significantly between the study groups.preeclamptic patients having the highest level of CCAT1in comparison with control group, However, preeclamptic patients having lower level of CDK4 than controls. No 35733554 CCAT1 LncRNA Homo sapiens endometrial adenocarcinoma endometrial cancer tissues Expression[highly expressed] qRT-PCR Median CCAT1 expression was found to be 9.3-fold higher in endometrial cancer when compared to normal endometrium (p < 0.05). No 32173521 CCAT1 LncRNA Homo sapiens acute myeloid leukemia AML samples regulation[CCAT1/miR-490-3p/MAPK1/c-Myc] qRT-PCR In this study, we demonstrated that CCAT1 was up-regulated in AML samples while its target, miR-490-3p, was relatively down-regulated. Our data implied that miR-490-3p could be a novel therapeutic target for AML, and highlights the crucial role of CCAT1/miR-490-3p/MAPK1/c-Myc positive feedback loop in AML progression. No 31790145 CCAT1 LncRNA Homo sapiens Tuberculosis N-TB patients Expression(highly expressed) qRT-PCR//ELISA On the day of admission, the highest levels of CCAT1, IFN-γ, IL-1β, iNOS, and TNF-α were detected in N-TB patients, followed by R-TB patients and controls, while the lowest levels of plasma IL-10 were detected in N-TB patients, followed by R-TB patients and controls. No 34847295 CCAT1 LncRNA Homo sapiens Colorectal Neoplasms tumours Expression(highly expressed) qRT-PCR//RNA-seq//Genotyping Expression of CCAT1, CCAT2 and c-Myc were significantly up-regulated in the tumours compared to matched mucosa (p < 0.0001). No 33432117 CBX1P1 LncRNA Homo sapiens Atrial Fibrillation AF tissues and matched controls Expression[lower expressed] RNA-seq Among the 557 lncRNAs, 30 and 767 were up-regulated and down-regulated in AF patients compared with controls, respectively. No 31843366 CBR3-AS1 LncRNA Homo sapiens Breast Neoplasms Fresh tissues Expression(highly expressed) qRT-PCR Although CBR3-AS1, RAB6C-AS1, and ZEB2-AS1 lncRNAs were found to have high expressions in the breast cancer cells, only CBR3-AS1 lncRNA has a high chance to be a breast cancer biomarker. No 34582659 CBR3-AS1 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CBL.11 CircRNA Homo sapiens Colorectal Neoplasms cell line Interaction[miR-6778-5p ] Microarray//IF MiR-6778-5p was sExpression[Expression[up-expression]-expression]pressed in CRC cells after irradiation. Results of functional experiments indicated that miR-6778-5p promoted the proliferation of CRC cells. Luciferase reporter analyses showed that YWHAE was a target of miR-6778-5p, which mediated the function of miR-6778-5p in the proliferation of CRC cells via the p53 pathway. Furthermore, we have noticed that after carbon ion irradiation, circRNA CBL.11 was increased in CRC cells and could function as a competing endogenous RNA (ceRNA) to regulate YWHAE expression by sponging miR-6778-5p, resulting in regulation the proliferation of CRC cells. No 31438886 CATG00000032642.1 LncRNA Homo sapiens COVID-19 39 COVID-19 patients Regulation qRT-PCR//Microarray All patients with COVID-19 displayed lymphopenia, especially in T cells, and hyper-inflammatory responses, including IL-6 and TNF-α. Four immune-related lncRNAs in COVID-19 were found and further validated, including AC136475.9, CATG00000032642.1, G004246, and XLOC_013290. No 35573725 CAST LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [lower expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CASP3P1 LncRNA Homo sapiens Stomach Neoplasms Gastric cancer tissue Expression[highly expressed] qRT-PCR//Microarray Microarray detection data showed that, of 114 metabolic pathway‐associated lncRNAs, 51 downregulated lncRNAs (Table ​(Table1)1) and 63 upregulated lncRNAs (Table ​(Table2)97) were significantly differentially expressed between the gastric cancer and adjacent nontumor tissues No 30320481 CASP1-214 LncRNA Homo sapiens Diabetes Mellitus, Type 1 Exosomal Expression(lower expressed) qRT-PCR//Western Blot A total of 162 differentially expressed exosomal lncRNAs were identified in T1DM patients compared with control subjects, among which 77 up-regulated and 85 down-regulated. No 35634499 CASC9 LncRNA Homo sapiens Breast Neoplasms cervical cancer tissues and cell lines Regulation[miR-215/TWIST2 signaling] RNA Pull-Down//Western Blot//RIP//qRT-PCR//Luciferase Report Assay//ELISA//Transwell Assay CASC9 expression was markedly increased in cervical cancer tissues and cell lines.Moreover, cancer-associated fibroblasts (CAFs)-derived transforming growth factor β (TGF-β) could increase CASC9 expression. The crosslink between CAFs and cervical cancer cells led to CASC9 to elevate the metastasis of cervical cancer cells. CASC9 dysregulation could function as a miRNA sponge to competitively protect twist homolog 2 (TWIST2) mRNA 3'UTR from miR-215. Cervical cancer patients with low CASC9 expression showed better overall survival rate. No 31178137 CASC9 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 CASC9 LncRNA Homo sapiens Colorectal Neoplasms TCGA Expression(highly expressed) qRT-PCR//Colony Formation Assay//Western Blot CASC9 was significantly upregulated as analyzed from both public datasets TCGA and ENCORI where its overexpression was associated with poor survival of CRC patients. Similarly, CASC9 was significantly overexpressed in the CRC cell lines compared with normal cells studied. The silencing of CASC9 in HCT-116 and SW480 attenuated cell proliferation and migration significantly. Furthermore, pathways investigations showed that silencing of CASC9 significantly induced autophagy, promoted AMP-activated protein kinase (AMPK) phosphorylation, inhibited mTOR and AKT signaling pathways, and altered epithelial-mesenchymal transition (EMT) marker protein expression. CASC9 was significantly upregulated as analyzed from both public datasets TCGA and ENCORI where its overexpression was associated with poor survival of CRC patients. No 34017854 CASC9 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Expression[highly expressed] qRT-PCR Analysis of data from TCGA database revealed that control samples showed significantly lower CASC9 expression than carcinoma tissue samples (P < 0.001); the low CASC9 expression group had a higher survival rate than the high CASC9 expression group (P = 0.011), and the patient group showed significantly increased expression of serum CASC9, with the area under the curve (AUC) of 0.933. CASC9 expression was related to tumor size, combined hepatitis, tumor, node, metastasis (TNM) staging, lymph node metastasis, differentiation and alpha fetoprotein, and the high CASC9 expression group showed lower 1-year, 3-year and 5-year survival rates than the low CASC9 expression group (all a P < 0.05). Multivariate Cox regression analysis revealed that TNM staging, lymph node metastasis, differentiation, alpha fetoprotein and CASC9 were independent factors affecting the prognosis of patients. No 31908394 CASC9 LncRNA Homo sapiens Squamous Cell Carcinoma of Head and Neck HNSCC tumor tissues Expression[Expression[highly expressed]-expression] qRT-PCR//Wound Healing Assay//MTT Analysis of TCGA pan-cancer data revealed significant overexpression of CASC9 across different other entities including bladder, liver, lung and stomach cancers and especially in squamous cell carcinoma (SCC) of the lung. No 31412811 CASC8 LncRNA Homo sapiens Carcinoma, Hepatocellular blood Mutation[ rs3843549 ] Genotyping Moreover, for patients stratified by age (under 65), gender (male only), or status of drinking (habitual drinkers), a protective effect of CASC8 rs3843549 on presenting high Child-Pugh scores, metastatic vascular invasion, or large-size tumors was observed in a dominant model. No 31398859 CASC8 LncRNA Homo sapiens pancreatic adenocarcinoma PAAD tissues,cell line Expression[highly expressed] qRT-PCR Results were consistent with our bioinformatic forecast: the expression of lncRNA-CASC8 and TOB1 was significantly upregulated in PAAD samples compared to in adjacent normal tissues, while the expression of miR-129a-5p was significantly down-regulated. Furthermore, expression status of lncRNA-CASC8 was detected in PAAD cell lines (Figure 7D). Results indicated that BXPC3 showed the highest expression level and Panc-1 had the lowest. Moreover, the expression levels of lncRNA-CASC8 in all PAAD cell lines were significantly higher than that in normal pancreatic ductal epithelium cells (HPDE cell line) (Figure 7D). No 33262608 CASC8 LncRNA Homo sapiens Esophageal Neoplasms Mutation[ rs1562430 A > G] Genotyping The CASC8 rs1562430 GG genotype was significantly associated with increased ESCC risk in men, patients younger than 63 years, non-smokers, and nondrinkers. No 32875717 CASC8 LncRNA Homo sapiens Retinoblastoma Rb tissue interaction[downregulating miR34a methylation] CCK8//qRT-PCR The results showed that CASC8 expression was upregulated and miR34a expression downregulated in Rb tissue. CASC8 may promote Rb cell proliferation by downregulating miR34a methylation. No 33408518 CASC8 LncRNA Homo sapiens Coronary Disease 464 CHD patients and 510 healthy controls Regulation Genotyping The study displayed the contribution of CASC8, CASC11, and PVT1 genetic polymorphisms to CHD predisposition, and these variants could serve as potential biomarkers of CHD susceptibility.Complications (hypertension or diabetes) of CHD influenced the association between CASC8, CASC11, and PVT1 genetic polymorphisms and CHD predisposition. Moreover, CASC8, CASC11, and PVT1 polymorphisms were related to the number of pathological branches and Gensini score in CHD patients. No 34001726 CASC8 LncRNA Homo sapiens Tuberculosis Mutation[rs7836840 ] Genotyping The lncRNA CASC8 genetic variant rs7836840 was associated with an increased tuberculosis risk with a P-value of .034, but .134 after Bonferroni correction. Using subtype analysis, the C allele in rs7836840 showed a significant association with tuberculosis susceptibility (OR = 1.196, 95% CI = 1.05-1.362, P = .02739 after Bonferroni correction). Patients carrying genotype AG and GG of rs7825118 and rs9297758 exhibited lower Hb concentrations (P = .006) and neutrophil counts (P = .015), respectively, while genotype AG and AA in rs6981424 demonstrated higher levels of ALT (P = .005) and AST (P = .033) in a dominant model, which were consistent with a tendency toward increased TB risk. No 32034808 CASC8 LncRNA Homo sapiens Diabetes Mellitus, Type 2 Sixty individuals Mutation(rs6983267 ) Genotyping TCF7L2 rs7903146, CASC8 rs6983267 and GREM1 rs16969681 could be risk factors for the association of T2DM with CRC. No 35893034 CASC20 LncRNA Homo sapiens Esophageal Squamous Cell Carcinoma cancer tissues Expression [highly expressed] qRT-PCR//RNA-seq We identified 1260 up-regulated/1445 down-regulated mRNAs and 402 up-regulated/741 down-regulated lncRNAs. Further functional analysis revealed differentially expressed genes (DEGs) of mRNA and lncRNA are related to different pathways. mRNA pathways are mainly involved in cell cycles while lncRNA pathways are for regulation and metabolic procession. Differentially expressed mRNAs/lncRNAs were validated with qPCR. No 29604464 XLOC_022497 LncRNA Oryctolagus cuniculus Atherosclerosis LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits Expression [lower expressed] RIP//IP//IF Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis-associated lncRNAs and genes provide hits for the experimental validation of lncRNA functions. No 29317334